New Diamond Color Center for Quantum Communication

NASA Astrophysics Data System (ADS)

Huang, Ding; Rose, Brendon; Tyryshkin, Alexei; Sangtawesin, Sorawis; Srinivasan, Srikanth; Twitchen, Daniel; Markham, Matthew; Edmonds, Andrew; Gali, Adam; Stacey, Alastair; Wang, Wuyi; D'Haenens-Johansson, Ulrika; Zaitsev, Alexandre; Lyon, Stephen; de Leon, Nathalie

2017-04-01

Color centers in diamond are attractive for quantum communication applications because of their long electron spin coherence times and efficient optical transitions. Previous demonstrations of color centers as solid-state spin qubits were primarily focused on centers that exhibit either long coherence times or highly efficient optical interfaces. Recently, we developed a method to stabilize the neutral charge state of silicon-vacancy center in diamond (SiV0) with high conversion efficiency. We observe spin relaxation times exceeding 1 minute and spin coherence times of 1 ms for SiV0 centers. Additionally, the SiV0 center also has > 90 % of its emission into its zero-phonon line and a narrow inhomogeneous optical linewidth. The combination of a long spin coherence time and efficient optical interface make the SiV0 center a promising candidate for applications in long distance quantum communication.

Nonlinear Sensing With Collective States of Ultracold Atoms in Optical Lattices

DTIC Science & Technology

2015-04-02

20) E. Tiesinga, “Particle-hole Pair Coherence in Mott insulator quench dynamics” at the June 2014, Division of atomic, molecular, and optical...Jian, Philip R. Johnson, Eite Tiesinga. Particle-Hole Pair Coherence in Mott Insulator Quench Dynamics, P H Y S I C A L R E V I EW L E T T E R S (01...lattices. We focused on techniques that make use of the coherent superposition states in atom number. These state are not unlike the photon number

3D in vivo imaging with extended-focus optical coherence microscopy.

PubMed

Chen, Yu; Trinh, Le A; Fingler, Jeff; Fraser, Scott E

2017-11-01

Optical coherence microscopy (OCM) has unique advantages of non-invasive 3D imaging without the need of exogenous labels for studying biological samples. However, the imaging depth of this technique is limited by the tradeoff between the depth of focus (DOF) and high lateral resolution in Gaussian optics. To overcome this limitation, we have developed an extended-focus OCM (xf-OCM) imaging system using quasi-Bessel beam illumination to extend the DOF to ∼100 μm, about 3-fold greater than standard OCM. High lateral resolution of 1.6 μm ensured detailed identification of structures within live animal samples. The insensitivity to spherical aberrations strengthened the capability of our xf-OCM system in 3D biological imaging. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Mitigation of Laser Beam Scintillation in Free-Space Optical Communication Systems Through Coherence-Reducing Optical Materials

NASA Technical Reports Server (NTRS)

Renner, Christoffer J.

2005-01-01

Free-space optical communication systems (also known as lasercom systems) offer several performance advantages over traditional radio frequency communication systems. These advantages include increased data rates and reduced operating power and system weight. One serious limiting factor in a lasercom system is Optical turbulence in Earth's atmosphere. This turbulence breaks up the laser beam used to transmit the information into multiple segments that interfere with each other when the beam is focused onto the receiver. This interference pattern at the receiver changes with time causing fluctuations in the received optical intensity (scintillation). Scintillation leads to intermittent losses of the signal and an overall reduction in the lasercom system's performance. Since scintillation is a coherent effect, reducing the spatial and temporal coherence of the laser beam will reduce the scintillation. Transmitting a laser beam through certain materials is thought to reduce its coherence. Materials that were tested included: sapphire, BK7 glass, fused silica and others. The spatial and temporal coherence of the laser beam was determined by examining the interference patterns (fringes) it formed when interacting with various interferometers and etalons.

Coherent fiber supercontinuum for biophotonics

PubMed Central

Tu, Haohua; Boppart, Stephen A.

2013-01-01

Biophotonics and nonlinear fiber optics have traditionally been two independent fields. Since the discovery of fiber-based supercontinuum generation in 1999, biophotonics applications employing incoherent light have experienced a large impact from nonlinear fiber optics, primarily because of the access to a wide range of wavelengths and a uniform spatial profile afforded by fiber supercontinuum. However, biophotonics applications employing coherent light have not benefited from the most well-known techniques of supercontinuum generation for reasons such as poor coherence (or high noise), insufficient controllability, and inadequate portability. Fortunately, a few key techniques involving nonlinear fiber optics and femtosecond laser development have emerged to overcome these critical limitations. Despite their relative independence, these techniques are the focus of this review, because they can be integrated into a low-cost portable biophotonics source platform. This platform can be shared across many different areas of research in biophotonics, enabling new applications such as point-of-care coherent optical biomedical imaging. PMID:24358056

Probing myocardium biomechanics using quantitative optical coherence elastography

NASA Astrophysics Data System (ADS)

Wang, Shang; Lopez, Andrew L.; Morikawa, Yuka; Tao, Ge; Li, Jiasong; Larina, Irina V.; Martin, James F.; Larin, Kirill V.

2015-03-01

We present a quantitative optical coherence elastographic method for noncontact assessment of the myocardium elasticity. The method is based on shear wave imaging optical coherence tomography (SWI-OCT), where a focused air-puff system is used to induce localized tissue deformation through a low-pressure short-duration air stream and a phase-sensitive OCT system is utilized to monitor the propagation of the induced tissue displacement with nanoscale sensitivity. The 1-D scanning of M-mode OCT imaging and the application of optical phase retrieval and mapping techniques enable the reconstruction and visualization of 2-D depth-resolved shear wave propagation in tissue with ultra-high frame rate. The feasibility of this method in quantitative elasticity measurement is demonstrated on tissue-mimicking phantoms with the estimated Young's modulus compared with uniaxial compression tests. We also performed pilot experiments on ex vivo mouse cardiac muscle tissues with normal and genetically altered cardiomyocytes. Our results indicate this noncontact quantitative optical coherence elastographic method can be a useful tool for the cardiac muscle research and studies.

Concept for image-guided vitreo-retinal fs-laser surgery: adaptive optics and optical coherence tomography for laser beam shaping and positioning

NASA Astrophysics Data System (ADS)

Matthias, Ben; Brockmann, Dorothee; Hansen, Anja; Horke, Konstanze; Knoop, Gesche; Gewohn, Timo; Zabic, Miroslav; Krüger, Alexander; Ripken, Tammo

2015-03-01

Fs-lasers are well established in ophthalmic surgery as high precision tools for corneal flap cutting during laser in situ keratomileusis (LASIK) and increasingly utilized for cutting the crystalline lens, e.g. in assisting cataract surgery. For addressing eye structures beyond the cornea, an intraoperative depth resolved imaging is crucial to the safety and success of the surgical procedure due to interindividual anatomical disparities. Extending the field of application even deeper to the posterior eye segment, individual eye aberrations cannot be neglected anymore and surgery with fs-laser is impaired by focus degradation. Our demonstrated concept for image-guided vitreo-retinal fs-laser surgery combines adaptive optics (AO) for spatial beam shaping and optical coherence tomography (OCT) for focus positioning guidance. The laboratory setup comprises an adaptive optics assisted 800 nm fs-laser system and is extended by a Fourier domain optical coherence tomography system. Phantom structures are targeted, which mimic tractional epiretinal membranes in front of excised porcine retina within an eye model. AO and OCT are set up to share the same scanning and focusing optics. A Hartmann-Shack sensor is employed for aberration measurement and a deformable mirror for aberration correction. By means of adaptive optics the threshold energy for laser induced optical breakdown is lowered and cutting precision is increased. 3D OCT imaging of typical ocular tissue structures is achieved with sufficient resolution and the images can be used for orientation of the fs-laser beam. We present targeted dissection of the phantom structures and its evaluation regarding retinal damage.

Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis

NASA Astrophysics Data System (ADS)

Bo, En; Liu, Linbo

2016-10-01

We developed a spectral domain optical coherence tomography (SD-OCT) with an extended depth-of-focus (DOF) by synthetizing aperture. For a designated Gaussian-shape light source, the lateral resolution was determined by the numerical aperture (NA) of the objective lens and can be approximately maintained over the confocal parameter, which was defined as twice the Rayleigh range. However, the DOF was proportional to the square of the lateral resolution. Consequently, a trade-off existed between the DOF and lateral resolution, and researchers had to weigh and judge which was more important for their research reasonably. In this study, three distinct optical apertures were obtained by imbedding a circular phase spacer in the sample arm. Due to the optical path difference between three distinct apertures caused by the phase spacer, three images were aligned with equal spacing along z-axis vertically. By correcting the optical path difference (OPD) and defocus-induced wavefront curvature, three images with distinct depths were coherently summed together. This system digitally refocused the sample tissue and obtained a brand new image with higher lateral resolution over the confocal parameter when imaging the polystyrene calibration beads.

Optical coherence elastography in ophthalmology

NASA Astrophysics Data System (ADS)

Kirby, Mitchell A.; Pelivanov, Ivan; Song, Shaozhen; Ambrozinski, Łukasz; Yoon, Soon Joon; Gao, Liang; Li, David; Shen, Tueng T.; Wang, Ruikang K.; O'Donnell, Matthew

2017-12-01

Optical coherence elastography (OCE) can provide clinically valuable information based on local measurements of tissue stiffness. Improved light sources and scanning methods in optical coherence tomography (OCT) have led to rapid growth in systems for high-resolution, quantitative elastography using imaged displacements and strains within soft tissue to infer local mechanical properties. We describe in some detail the physical processes underlying tissue mechanical response based on static and dynamic displacement methods. Namely, the assumptions commonly used to interpret displacement and strain measurements in terms of tissue elasticity for static OCE and propagating wave modes in dynamic OCE are discussed with the ultimate focus on OCT system design for ophthalmic applications. Practical OCT motion-tracking methods used to map tissue elasticity are also presented to fully describe technical developments in OCE, particularly noting those focused on the anterior segment of the eye. Clinical issues and future directions are discussed in the hope that OCE techniques will rapidly move forward to translational studies and clinical applications.

Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging

PubMed Central

Cua, Michelle; Wahl, Daniel J.; Zhao, Yuan; Lee, Sujin; Bonora, Stefano; Zawadzki, Robert J.; Jian, Yifan; Sarunic, Marinko V.

2016-01-01

Multiphoton microscopy enables imaging deep into scattering tissues. The efficient generation of non-linear optical effects is related to both the pulse duration (typically on the order of femtoseconds) and the size of the focused spot. Aberrations introduced by refractive index inhomogeneity in the sample distort the wavefront and enlarge the focal spot, which reduces the multiphoton signal. Traditional approaches to adaptive optics wavefront correction are not effective in thick or multi-layered scattering media. In this report, we present sensorless adaptive optics (SAO) using low-coherence interferometric detection of the excitation light for depth-resolved aberration correction of two-photon excited fluorescence (TPEF) in biological tissue. We demonstrate coherence-gated SAO TPEF using a transmissive multi-actuator adaptive lens for in vivo imaging in a mouse retina. This configuration has significant potential for reducing the laser power required for adaptive optics multiphoton imaging, and for facilitating integration with existing systems. PMID:27599635

Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging.

PubMed

Cua, Michelle; Wahl, Daniel J; Zhao, Yuan; Lee, Sujin; Bonora, Stefano; Zawadzki, Robert J; Jian, Yifan; Sarunic, Marinko V

2016-09-07

Multiphoton microscopy enables imaging deep into scattering tissues. The efficient generation of non-linear optical effects is related to both the pulse duration (typically on the order of femtoseconds) and the size of the focused spot. Aberrations introduced by refractive index inhomogeneity in the sample distort the wavefront and enlarge the focal spot, which reduces the multiphoton signal. Traditional approaches to adaptive optics wavefront correction are not effective in thick or multi-layered scattering media. In this report, we present sensorless adaptive optics (SAO) using low-coherence interferometric detection of the excitation light for depth-resolved aberration correction of two-photon excited fluorescence (TPEF) in biological tissue. We demonstrate coherence-gated SAO TPEF using a transmissive multi-actuator adaptive lens for in vivo imaging in a mouse retina. This configuration has significant potential for reducing the laser power required for adaptive optics multiphoton imaging, and for facilitating integration with existing systems.

Characterization of the dental pulp using optical coherence tomography

NASA Astrophysics Data System (ADS)

Kauffman, C. M. F.; Carvalho, M. T.; Araujo, R. E.; Freitas, A. Z.; Zezell, D. M.; Gomes, A. S. L.

2006-02-01

The inner structure of teeth, i.e. the root canal anatomy, is very complex. However a good knowledge of endodontic architecture is the first step towards successful endodontic treatment. Optical coherence tomography (OCT) is a powerful technique to generate images of hard and soft tissue. Its images show dependency on the optical properties of the tissue under analysis. Changes in the scattering and absorption of tissues can be observed through the OCT images. In this work, we used optical coherence tomography to perform in vitro studies of the inner structure of the first molar of albino rats (Rattus norvegicus). Focusing on the pulp chamber and in the root canal, we compare the images generated with the OCT technique to the histology. We are analyzing the feasibility of OCT to help on the diagnostic of endodontic diseases.

Practical somewhat-secure quantum somewhat-homomorphic encryption with coherent states

NASA Astrophysics Data System (ADS)

Tan, Si-Hui; Ouyang, Yingkai; Rohde, Peter P.

2018-04-01

We present a scheme for implementing homomorphic encryption on coherent states encoded using phase-shift keys. The encryption operations require only rotations in phase space, which commute with computations in the code space performed via passive linear optics, and with generalized nonlinear phase operations that are polynomials of the photon-number operator in the code space. This encoding scheme can thus be applied to any computation with coherent-state inputs, and the computation proceeds via a combination of passive linear optics and generalized nonlinear phase operations. An example of such a computation is matrix multiplication, whereby a vector representing coherent-state amplitudes is multiplied by a matrix representing a linear optics network, yielding a new vector of coherent-state amplitudes. By finding an orthogonal partitioning of the support of our encoded states, we quantify the security of our scheme via the indistinguishability of the encrypted code words. While we focus on coherent-state encodings, we expect that this phase-key encoding technique could apply to any continuous-variable computation scheme where the phase-shift operator commutes with the computation.

Optical coherence microscope for invariant high resolution in vivo skin imaging

NASA Astrophysics Data System (ADS)

Murali, S.; Lee, K. S.; Meemon, P.; Rolland, J. P.

2008-02-01

A non-invasive, reliable and affordable imaging system with the capability of detecting skin pathologies such as skin cancer would be a valuable tool to use for pre-screening and diagnostic applications. Optical Coherence Microscopy (OCM) is emerging as a building block for in vivo optical diagnosis, where high numerical aperture optics is introduced in the sample arm to achieve high lateral resolution. While high numerical aperture optics enables realizing high lateral resolution at the focus point, dynamic focusing is required to maintain the target lateral resolution throughout the depth of the sample being imaged. In this paper, we demonstrate the ability to dynamically focus in real-time with no moving parts to a depth of up to 2mm in skin-equivalent tissue in order to achieve 3.5μm lateral resolution throughout an 8 cubic millimeter sample. The built-in dynamic focusing ability is provided by an addressable liquid lens embedded in custom-designed optics which was designed for a broadband laser source of 120 nm bandwidth centered at around 800nm. The imaging probe was designed to be low-cost and portable. Design evaluation and tolerance analysis results show that the probe is robust to manufacturing errors and produces consistent high performance throughout the imaging volume.

Integrated coherent matter wave circuits

DOE PAGES

Ryu, C.; Boshier, M. G.

2015-09-21

An integrated coherent matter wave circuit is a single device, analogous to an integrated optical circuit, in which coherent de Broglie waves are created and then launched into waveguides where they can be switched, divided, recombined, and detected as they propagate. Applications of such circuits include guided atom interferometers, atomtronic circuits, and precisely controlled delivery of atoms. We report experiments demonstrating integrated circuits for guided coherent matter waves. The circuit elements are created with the painted potential technique, a form of time-averaged optical dipole potential in which a rapidly moving, tightly focused laser beam exerts forces on atoms through theirmore » electric polarizability. Moreover, the source of coherent matter waves is a Bose–Einstein condensate (BEC). Finally, we launch BECs into painted waveguides that guide them around bends and form switches, phase coherent beamsplitters, and closed circuits. These are the basic elements that are needed to engineer arbitrarily complex matter wave circuitry.« less

Extended depth of focus adaptive optics spectral domain optical coherence tomography

PubMed Central

Sasaki, Kazuhiro; Kurokawa, Kazuhiro; Makita, Shuichi; Yasuno, Yoshiaki

2012-01-01

We present an adaptive optics spectral domain optical coherence tomography (AO-SDOCT) with a long focal range by active phase modulation of the pupil. A long focal range is achieved by introducing AO-controlled third-order spherical aberration (SA). The property of SA and its effects on focal range are investigated in detail using the Huygens-Fresnel principle, beam profile measurement and OCT imaging of a phantom. The results indicate that the focal range is extended by applying SA, and the direction of extension can be controlled by the sign of applied SA. Finally, we demonstrated in vivo human retinal imaging by altering the applied SA. PMID:23082278

Extended depth of focus adaptive optics spectral domain optical coherence tomography.

PubMed

Sasaki, Kazuhiro; Kurokawa, Kazuhiro; Makita, Shuichi; Yasuno, Yoshiaki

2012-10-01

We present an adaptive optics spectral domain optical coherence tomography (AO-SDOCT) with a long focal range by active phase modulation of the pupil. A long focal range is achieved by introducing AO-controlled third-order spherical aberration (SA). The property of SA and its effects on focal range are investigated in detail using the Huygens-Fresnel principle, beam profile measurement and OCT imaging of a phantom. The results indicate that the focal range is extended by applying SA, and the direction of extension can be controlled by the sign of applied SA. Finally, we demonstrated in vivo human retinal imaging by altering the applied SA.

Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system.

PubMed

Wang, Shang; Li, Jiasong; Manapuram, Ravi Kiran; Menodiado, Floredes M; Ingram, Davis R; Twa, Michael D; Lazar, Alexander J; Lev, Dina C; Pollock, Raphael E; Larin, Kirill V

2012-12-15

We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.

Comment on Sub-15 nm Hard X-Ray Focusing with a New Total-Reflection Zone Plate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Specht, Eliot D

2011-01-01

Takano et al. report the focusing of 10-keV X-rays to a size of 14.4 nm using a total-reflection zone plate (TRZP). This focal size is at the diffraction limit for the optic's aperture. This would be a noteworthy result, since the TRZP was fabricated using conventional lithography techniques. Alternative nanofocusing optics require more demanding fabrication methods. However, as I will discuss in this Comment, the intensity distribution presented by Takano et al. (Fig. 4 of ref. 1) is more consistent with the random speckle pattern produced by the scattering of a coherent incident beam by a distorted optic than withmore » a diffraction-limited focus. When interpreted in this manner, the true focal spot size is {approx}70 nm: 5 times the diffraction limit. When a coherent photon beam illuminates an optic containing randomly distributed regions which introduce different phase shifts, the scattered diffraction pattern consists of a speckle pattern. Each speckle will be diffraction-limited: the peak width of a single speckle depends entirely on the source coherence and gives no information about the optic. The envelope of the speckle distribution corresponds to the focal spot which would be observed using incoherent illumination. The width of this envelope is due to the finite size of the coherently-diffracting domains produced by slope and position errors in the optic. The focal intensity distribution in Fig. 4 of ref. 1 indeed contains a diffraction-limited peak, but this peak contains only a fraction of the power in the focused, and forms part of a distribution of sharp peaks with an envelope {approx}70 nm in width, just as expected for a speckle pattern. At the 4mm focal distance, the 70 nm width corresponds to a slope error of 18 {micro}rad. To reach the 14 nm diffraction limit, the slope error must be reduced to 3 {micro}rad. Takano et al. have identified a likely source of this error: warping due to stress as a result of zone deposition. It will be interesting to see whether the use of a more rigid substrate gives improved results.« less

Engineering of Nanoscale Contrast Agents for Optical Coherence Tomography.

PubMed

Gordon, Andrew Y; Jayagopal, Ashwath

2014-01-30

Optical coherence tomography has emerged as valuable imaging modalityin ophthalmology and other fields by enabling high-resolution three-dimensional imaging of tissue. In this paper, we review recent progress in the field of contrast-enhanced optical coherence tomography (OCT). We discuss exogenous and endogenous sources of OCT contrast, focusing on their use with standard OCT systems as well as emerging OCT-based imaging modalities. We include advances in the processing of OCT data that generate improved tissue contrast, including spectroscopic OCT (SOCT), as well as work utilizing secondary light sources and/or detection mechanisms to create and detect enhanced contrast, including photothermal OCT (PTOCT) and photoacoustic OCT (PAOCT). Finally, we conclude with a discussion of the translational potential of these developments as well as barriers to their clinical use.

Advanced X-ray Optics Metrology for Nanofocusing and Coherence Preservation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldberg, Kenneth A.; Yashchuk, Valeriy

2007-12-01

What is the point of developing new high-brightness light sources if beamline optics won't be available to realize the goals of nano-focusing and coherence preservation? That was one of the central questions raised during a workshop at the 2007 Advanced Light Source Users Meeting. Titled, 'Advanced X-Ray Optics Metrology for Nano-focusing and Coherence Preservation', the workshop was organized by Kenneth Goldberg and Valeriy Yashchuk (both of Lawrence Berkeley National Laboratory, LBNL), and it brought together industry representatives and researchers from Japan, Europe, and the US to discuss the state of the art and to outline the optics requirements of newmore » light sources. Many of the presentations are viewable on the workshop website http://goldberg.lbl.gov/MetrologyWorkshop07/. Many speakers shared the same view of one of the most significant challenges facing the development of new high-brightness third and fourth generation x-ray, soft x-ray, and EUV light sources: these sources place extremely high demands on the surface quality of beamline optics. In many cases, the 1-2-nm surface error specs that define the outer bounds of 'diffraction-limited' quality are beyond the reach of leading facilities and optics vendors. To focus light to 50-nm focal spots, or smaller, from reflective optics and to preserve the high coherent flux that new sources make possible, the optical surface quality and alignment tolerances must be measured in nano-meters and nano-radians. Without a significant, well-supported research effort, including the development of new metrology techniques for use both on and off the beamline, these goals will likely not be met. The scant attention this issue has garnered is evident in the stretched budgets and limited manpower currently dedicated to metrology. With many of the world's leading groups represented at the workshop, it became clear that Japan and Europe are several steps ahead of the US in this critical area. But the situation isn't all dire: several leading groups are blazing a trail forward, and the recognition of this issue is increasing. The workshop featured eleven invited talks whose presenters came from Japan, Europe, and the US.« less

The tight focusing properties of Laguerre-Gaussian-correlated Schell-model beams

NASA Astrophysics Data System (ADS)

Xu, Hua-Feng; Zhang, Zhou; Qu, Jun; Huang, Wei

2016-08-01

Based on the Richards-Wolf vectorial diffraction theory, the tight focusing properties, including the intensity distribution, the degree of polarization and the degree of coherence, of the Laguerre-Gaussian-correlated Schell-model (LGSM) beams through a high-numerical-aperture (NA) focusing system are investigated in detail. It is found that the LGSM beam exhibits some extraordinary focusing properties, which is quite different from that of the GSM beam, and the tight focusing properties are closely related to the initial spatial coherence ? and the mode order n. The LGSM beam can form an elliptical focal spot, a circular focal spot or a doughnut-shaped dark hollow beam at the focal plane by choosing a suitable value of the initial spatial coherence ?, and the central dark size of the dark hollow beam increases with the increase of the mode order n. In addition, the influences of the initial spatial coherence ? and the mode order n on the degree of polarization and the degree of coherence are also analysed in detail, respectively. Our results may find applications in optical trapping.

Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm

NASA Astrophysics Data System (ADS)

Cua, Michelle; Liu, Xiyun; Miao, Dongkai; Lee, Sujin; Lee, Sieun; Bonora, Stefano; Zawadzki, Robert J.; Mackenzie, Paul J.; Jian, Yifan; Sarunic, Marinko V.

2015-03-01

High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-time. A GPU-accelerated segmentation and optimization was used to provide real-time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Endoscopic optical coherence tomography with a focus-adjustable probe.

PubMed

Liao, Wenchao; Chen, Tianyuan; Wang, Chengming; Zhang, Wenxin; Peng, Zhangkai; Zhang, Xiao; Ai, Shengnan; Fu, Deyong; Zhou, Tieying; Xue, Ping

2017-10-15

We present a focus-adjustable endoscopic probe for optical coherence tomography (OCT), which is able to acquire images with different focal planes and overcome depth-of-focus limitations by image fusing. The use of a two-way shape-memory-alloy spring enables the probe to adjust working distance over 1.5 mm, providing a large scanning range with high resolution and no sensitivity loss. Equipped with a homemade hollow-core ultrasonic motor, the probe is capable of performing an unobstructed 360 deg field-of-view distal scanning. Both the axial resolution and the best lateral resolution are ∼4  μm, with a sensitivity of 100.3 dB. Spectral-domain OCT imaging of phantom and biological tissues with the probe is also demonstrated.

Clinical Utility of Optical Coherence Tomography in Glaucoma

PubMed Central

Dong, Zachary M.; Wollstein, Gadi; Schuman, Joel S.

2016-01-01

Optical coherence tomography (OCT) has established itself as the dominant imaging modality in the management of glaucoma and retinal diseases, providing high-resolution visualization of ocular microstructures and objective quantification of tissue thickness and change. This article reviews the history of OCT imaging with a specific focus on glaucoma. We examine the clinical utility of OCT with respect to diagnosis and progression monitoring, with additional emphasis on advances in OCT technology that continue to facilitate glaucoma research and inform clinical management strategies. PMID:27537415

Ultrahigh resolution optical coherence elastography using a Bessel beam for extended depth of field

NASA Astrophysics Data System (ADS)

Curatolo, Andrea; Villiger, Martin; Lorenser, Dirk; Wijesinghe, Philip; Fritz, Alexander; Kennedy, Brendan F.; Sampson, David D.

2016-03-01

Visualizing stiffness within the local tissue environment at the cellular and sub-cellular level promises to provide insight into the genesis and progression of disease. In this paper, we propose ultrahigh-resolution optical coherence elastography, and demonstrate three-dimensional imaging of local axial strain of tissues undergoing compressive loading. The technique employs a dual-arm extended focus optical coherence microscope to measure tissue displacement under compression. The system uses a broad bandwidth supercontinuum source for ultrahigh axial resolution, Bessel beam illumination and Gaussian beam detection, maintaining sub-2 μm transverse resolution over nearly 100 μm depth of field, and spectral-domain detection allowing high displacement sensitivity. The system produces strain elastograms with a record resolution (x,y,z) of 2×2×15 μm. We benchmark the advances in terms of resolution and strain sensitivity by imaging a suitable inclusion phantom. We also demonstrate this performance on freshly excised mouse aorta and reveal the mechanical heterogeneity of vascular smooth muscle cells and elastin sheets, otherwise unresolved in a typical, lower resolution optical coherence elastography system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryu, C.; Boshier, M. G.

An integrated coherent matter wave circuit is a single device, analogous to an integrated optical circuit, in which coherent de Broglie waves are created and then launched into waveguides where they can be switched, divided, recombined, and detected as they propagate. Applications of such circuits include guided atom interferometers, atomtronic circuits, and precisely controlled delivery of atoms. We report experiments demonstrating integrated circuits for guided coherent matter waves. The circuit elements are created with the painted potential technique, a form of time-averaged optical dipole potential in which a rapidly moving, tightly focused laser beam exerts forces on atoms through theirmore » electric polarizability. Moreover, the source of coherent matter waves is a Bose–Einstein condensate (BEC). Finally, we launch BECs into painted waveguides that guide them around bends and form switches, phase coherent beamsplitters, and closed circuits. These are the basic elements that are needed to engineer arbitrarily complex matter wave circuitry.« less

Coherent receiver design based on digital signal processing in optical high-speed intersatellite links with M-phase-shift keying

NASA Astrophysics Data System (ADS)

Schaefer, Semjon; Gregory, Mark; Rosenkranz, Werner

2016-11-01

We present simulative and experimental investigations of different coherent receiver designs for high-speed optical intersatellite links. We focus on frequency offset (FO) compensation in homodyne and intradyne detection systems. The considered laser communication terminal uses an optical phase-locked loop (OPLL), which ensures stable homodyne detection. However, the hardware complexity increases with the modulation order. Therefore, we show that software-based intradyne detection is an attractive alternative for OPLL-based homodyne systems. Our approach is based on digital FO and phase noise compensation, in order to achieve a more flexible coherent detection scheme. Analytic results will further show the theoretical impact of the different detection schemes on the receiver sensitivity. Finally, we compare the schemes in terms of bit error ratio measurements and optimal receiver design.

Dynamical scattering in coherent hard x-ray nanobeam Bragg diffraction

NASA Astrophysics Data System (ADS)

Pateras, A.; Park, J.; Ahn, Y.; Tilka, J. A.; Holt, M. V.; Kim, H.; Mawst, L. J.; Evans, P. G.

2018-06-01

Unique intensity features arising from dynamical diffraction arise in coherent x-ray nanobeam diffraction patterns of crystals having thicknesses larger than the x-ray extinction depth or exhibiting combinations of nanoscale and mesoscale features. We demonstrate that dynamical scattering effects can be accurately predicted using an optical model combined with the Darwin theory of dynamical x-ray diffraction. The model includes the highly divergent coherent x-ray nanobeams produced by Fresnel zone plate focusing optics and accounts for primary extinction, multiple scattering, and absorption. The simulation accurately reproduces the dynamical scattering features of experimental diffraction patterns acquired from a GaAs/AlGaAs epitaxial heterostructure on a GaAs (001) substrate.

Optical Tecnology Developments in Biomedicine: History, Current and Future

PubMed Central

Nioka, Shoko; Chen, Yu

2011-01-01

Biomedical optics is a rapidly emerging field for medical imaging and diagnostics. This paper reviews several biomedical optical technologies that have been developed and translated for either clinical or pre-clinical applications. Specifically, we focus on the following technologies: 1) near-infrared spectroscopy and tomography, 2) optical coherence tomography, 3) fluorescence spectroscopy and imaging, and 4) optical molecular imaging. There representative biomedical applications are also discussed here. PMID:23905030

X-ray optics simulation and beamline design for the APS upgrade

NASA Astrophysics Data System (ADS)

Shi, Xianbo; Reininger, Ruben; Harder, Ross; Haeffner, Dean

2017-08-01

The upgrade of the Advanced Photon Source (APS) to a Multi-Bend Achromat (MBA) will increase the brightness of the APS by between two and three orders of magnitude. The APS upgrade (APS-U) project includes a list of feature beamlines that will take full advantage of the new machine. Many of the existing beamlines will be also upgraded to profit from this significant machine enhancement. Optics simulations are essential in the design and optimization of these new and existing beamlines. In this contribution, the simulation tools used and developed at APS, ranging from analytical to numerical methods, are summarized. Three general optical layouts are compared in terms of their coherence control and focusing capabilities. The concept of zoom optics, where two sets of focusing elements (e.g., CRLs and KB mirrors) are used to provide variable beam sizes at a fixed focal plane, is optimized analytically. The effects of figure errors on the vertical spot size and on the local coherence along the vertical direction of the optimized design are investigated.

Bulk diamond optical waveguides fabricated by focused femtosecond laser pulses

NASA Astrophysics Data System (ADS)

Hadden, J. P.; Sotillo, Belén.; Bharadwaj, Vibhav; Rampini, Stefano; Bosia, Federico; Picollo, Federico; Sakakura, Masaaki; Chiappini, Andrea; Fernandez, Toney T.; Osellame, Roberto; Miura, Kiyotaka; Ferrari, Maurizio; Ramponi, Roberta; Olivero, Paolo; Barclay, Paul E.; Eaton, Shane M.

2017-02-01

Diamond's nitrogen-vacancy (NV) centers show great promise in sensing applications and quantum computing due to their long electron spin coherence time and their ability to be located, manipulated and read out using light. The electrons of the NV center, largely localized at the vacancy site, combine to form a spin triplet, which can be polarized with 532- nm laser light, even at room temperature. The NV's states are isolated from environmental perturbations making their spin coherence comparable to trapped ions. An important breakthrough would be in connecting, using waveguides, multiple diamond NVs together optically. However, the inertness of diamond is a significant hurdle for the fabrication of integrated optics similar to those that revolutionized silicon photonics. In this work we show the possibility of buried waveguide fabrication in diamond, enabled by focused femtosecond high repetition rate laser pulses. We use μRaman spectroscopy to gain better insight into the structure and refractive index profile of the optical waveguides.

X-ray optical simulations supporting advanced commissioning of the coherent hard x-ray beamline at NSLS-II

NASA Astrophysics Data System (ADS)

Wiegart, L.; Rakitin, M.; Fluerasu, A.; Chubar, O.

2017-08-01

We present the application of fully- and partially-coherent synchrotron radiation wavefront propagation simulation functions, implemented in the "Synchrotron Radiation Workshop" computer code, to create a `virtual beamline' mimicking the Coherent Hard X-ray scattering beamline at NSLS-II. The beamline simulation includes all optical beamline components, such as the insertion device, mirror with metrology data, slits, double crystal monochromator and refractive focusing elements (compound refractive lenses and kinoform lenses). A feature of this beamline is the exploitation of X-ray beam coherence, boosted by the low-emittance NSLS-II storage-ring, for techniques such as X-ray Photon Correlation Spectroscopy or Coherent Diffraction Imaging. The key performance parameters are the degree of Xray beam coherence and photon flux, and the trade-off between them needs to guide the beamline settings for specific experimental requirements. Simulations of key performance parameters are compared to measurements obtained during beamline commissioning, and include the spectral flux of the undulator source, the degree of transverse coherence as well as focal spot sizes.

Path-length-resolved dynamic light scattering in highly scattering random media: The transition to diffusing wave spectroscopy

NASA Astrophysics Data System (ADS)

Bizheva, Kostadinka K.; Siegel, Andy M.; Boas, David A.

1998-12-01

We used low coherence interferometry to measure Brownian motion within highly scattering random media. A coherence gate was applied to resolve the optical path-length distribution and to separate ballistic from diffusive light. Our experimental analysis provides details on the transition from single scattering to light diffusion and its dependence on the system parameters. We found that the transition to the light diffusion regime occurs at shorter path lengths for media with higher scattering anisotropy or for larger numerical aperture of the focusing optics.

CAPILLARY NETWORK ANOMALIES IN BRANCH RETINAL VEIN OCCLUSION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

PubMed

Rispoli, Marco; Savastano, Maria Cristina; Lumbroso, Bruno

2015-11-01

To analyze the foveal microvasculature features in eyes with branch retinal vein occlusion (BRVO) using optical coherence tomography angiography based on split spectrum amplitude decorrelation angiography technology. A total of 10 BRVO eyes (mean age 64.2 ± 8.02 range between 52 years and 76 years) were evaluated by optical coherence tomography angiography (XR-Avanti; Optovue). The macular angiography scan protocol covered a 3 mm × 3 mm area. The focus of angiography analysis were two retinal layers: superficial vascular network and deep vascular network. The following vascular morphological congestion parameters were assessed in the vein occlusion area in both the superficial and deep networks: foveal avascular zone enlargement, capillary non-perfusion occurrence, microvascular abnormalities appearance, and vascular congestion signs. Image analyses were performed by 2 masked observers and interobserver agreement of image analyses was 0.90 (κ = 0.225, P < 0.01). In both superficial and deep network of BRVO, a decrease in capillary density with foveal avascular zone enlargement, capillary non-perfusion occurrence, and microvascular abnormalities appearance was observed (P < 0.01). The deep network showed the main vascular congestion at the boundary between healthy and nonperfused retina. Optical coherence tomography angiography in BRVO allows to detect foveal avascular zone enlargement, capillary nonperfusion, microvascular abnormalities, and vascular congestion signs both in the superficial and deep capillary network in all eyes. Optical coherence tomography angiography technology is a potential clinical tool for BRVO diagnosis and follow-up, providing stratigraphic vascular details that have not been previously observed by standard fluorescein angiography. The normal retinal vascular nets and areas of nonperfusion and congestion can be identified at various retinal levels. Optical coherence tomography angiography provides noninvasive images of the retinal capillaries and vascular networks.

A novel coherent optical en/decoder for optical label processing of OCDM-based optical packets switching networks

NASA Astrophysics Data System (ADS)

Zhang, Chongfu; Qiu, Kun

2007-11-01

A coherent optical en/decoder based on photonic crystal (PhC) for optical code-division-multiple (OCDM)-based optical label (OCDM-OL) optical packets switching (OPS) networks is proposed in this paper. In this scheme, the optical pulse phase and time delay can be flexibly controlled by the photonic crystal phase shifter and delayer using the appropriate design of fabrication. In this design, the combination calculation of the impurity and normal period layers is applied, according to the PhC transmission matrix theorem. The design and theoretical analysis of the PhC-based optical coherent en/decoder is mainly focused. In addition, the performances of the PhC-based optical en/decoders are analyzed in detail. The reflection, the transmission, delay characteristic and the optical spectrum of pulse en/decoded are studied for the waves tuned in the photonic band-gap by the numerical calculation, taking into account 1-Dimension (1D) PhC. Theoretical analysis and numerical results show that optical pulse is achieved to properly phase modulation and time delay by the proposed scheme, optical label based on OCDM is rewrote successfully by new code for OCDM-based OPS (OCDM-OPS), and an over 8.5 dB ration of auto- and cross-correlation is gained, which demonstrates the applicability of true pulse phase modulation in a number of applications.

Optics for coherent X-ray applications.

PubMed

Yabashi, Makina; Tono, Kensuke; Mimura, Hidekazu; Matsuyama, Satoshi; Yamauchi, Kazuto; Tanaka, Takashi; Tanaka, Hitoshi; Tamasaku, Kenji; Ohashi, Haruhiko; Goto, Shunji; Ishikawa, Tetsuya

2014-09-01

Developments of X-ray optics for full utilization of diffraction-limited storage rings (DLSRs) are presented. The expected performance of DLSRs is introduced using the design parameters of SPring-8 II. To develop optical elements applicable to manipulation of coherent X-rays, advanced technologies on precise processing and metrology were invented. With propagation-based coherent X-rays at the 1 km beamline of SPring-8, a beryllium window fabricated with the physical-vapour-deposition method was found to have ideal speckle-free properties. The elastic emission machining method was utilized for developing reflective mirrors without distortion of the wavefronts. The method was further applied to production of diffraction-limited focusing mirrors generating the smallest spot size in the sub-10 nm regime. To enable production of ultra-intense nanobeams at DLSRs, a low-vibration cooling system for a high-heat-load monochromator and advanced diagnostic systems to characterize X-ray beam properties precisely were developed. Finally, new experimental schemes for combinative nano-analysis and spectroscopy realised with novel X-ray optics are discussed.

Coherent control of plasmonic nanoantennas using optical eigenmodes

NASA Astrophysics Data System (ADS)

Kosmeier, Sebastian; de Luca, Anna Chiara; Zolotovskaya, Svetlana; di Falco, Andrea; Dholakia, Kishan; Mazilu, Michael

2013-05-01

The last decade has seen subwavelength focusing of the electromagnetic field in the proximity of nanoplasmonic structures with various designs. However, a shared issue is the spatial confinement of the field, which is mostly inflexible and limited to fixed locations determined by the geometry of the nanostructures, which hampers many applications. Here, we coherently address numerically and experimentally single and multiple plasmonic nanostructures chosen from a given array, resorting to the principle of optical eigenmodes. By decomposing the light field into optical eigenmodes, specifically tailored to the nanostructure, we create a subwavelength, selective and dynamic control of the incident light. The coherent control of plasmonic nanoantennas using this approach shows an almost zero crosstalk. This approach is applicable even in the presence of large transmission aberrations, such as present in holographic diffusers and multimode fibres. The method presents a paradigm shift for the addressing of plasmonic nanostructures by light.

Ultrathin forward-imaging short multimode fiber probe for full-field optical coherence microscopy

NASA Astrophysics Data System (ADS)

Sato, Manabu; Saito, Daisuke; Shouji, Kou; Kurotani, Reiko; Abe, Hiroyuki; Nishidate, Izumi

2016-12-01

To extend the applications of optical coherence tomography (OCT) to the fields of physiology and clinical medicine, less invasive, robust, and reliable optical probes are required. Thus, we demonstrate an ultrathin forward-imaging short multimode fiber (SMMF) optical coherence microscopy (OCM) probe with a 50 μm core diameter, 125 μm total diameter, and 5.12 mm length. Imaging conditions and magnification were analyzed, and they correspond closely to the measured results. The dispersion of the SMMF was investigated, and the modal dispersion coefficient was found to be 2.3% of the material dispersion coefficient. The axial resolution was minimized at 2.15 μm using a 0.885-mm-thick dispersion compensator. The lateral resolution was evaluated to be 4.38 μm using a test pattern. The contrast of the OCM images was 5.7 times higher than that of the signal images owing to the coherence gate. The depth of focus and diameter of the field of view were measured to be 60 μm and 40-50 μm, respectively. OCM images of the dried fins of small fish (Medaka) were measured and internal structures could be recognized.

Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens Using a Coaligned Ultrasound and Optical Coherence Elastography System

PubMed Central

Wu, Chen; Han, Zhaolong; Wang, Shang; Li, Jiasong; Singh, Manmohan; Liu, Chih-hao; Aglyamov, Salavat; Emelianov, Stanislav; Manns, Fabrice; Larin, Kirill V.

2015-01-01

Purpose. To evaluate the capability of a novel, coaligned focused ultrasound and phase-sensitive optical coherence elastography (US-OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in situ. Methods. Low-amplitude elastic deformations in young and mature rabbit lenses were measured by an US-OCE system consisting of a spectral-domain optical coherence tomography (OCT) system coaligned with a focused ultrasound system used to produce a transient force on the lens surface. Uniaxial compressional tests were used to validate the OCE data. Results. The OCE measurements showed that the maximum displacements of the young rabbit lenses were significantly larger than those of the mature lenses, indicating a gradual increase of the lens stiffness with age. Temporal analyses of the displacements also demonstrate a similar trend of elastic properties in these lenses. The stress-strain measurements using uniaxial mechanical tests confirmed the results obtained by the US-OCE system. Conclusions. The results demonstrate that the US-OCE system can be used for noninvasive analysis and quantification of lens biomechanical properties in situ and possibly in vivo. PMID:25613945

Spectromicroscopy and coherent diffraction imaging: focus on energy materials applications.

PubMed

Hitchcock, Adam P; Toney, Michael F

2014-09-01

Current and future capabilities of X-ray spectromicroscopy are discussed based on coherence-limited imaging methods which will benefit from the dramatic increase in brightness expected from a diffraction-limited storage ring (DLSR). The methods discussed include advanced coherent diffraction techniques and nanoprobe-based real-space imaging using Fresnel zone plates or other diffractive optics whose performance is affected by the degree of coherence. The capabilities of current systems, improvements which can be expected, and some of the important scientific themes which will be impacted are described, with focus on energy materials applications. Potential performance improvements of these techniques based on anticipated DLSR performance are estimated. Several examples of energy sciences research problems which are out of reach of current instrumentation, but which might be solved with the enhanced DLSR performance, are discussed.

Partially coherent X-ray wavefront propagation simulations including grazing-incidence focusing optics.

PubMed

Canestrari, Niccolo; Chubar, Oleg; Reininger, Ruben

2014-09-01

X-ray beamlines in modern synchrotron radiation sources make extensive use of grazing-incidence reflective optics, in particular Kirkpatrick-Baez elliptical mirror systems. These systems can focus the incoming X-rays down to nanometer-scale spot sizes while maintaining relatively large acceptance apertures and high flux in the focused radiation spots. In low-emittance storage rings and in free-electron lasers such systems are used with partially or even nearly fully coherent X-ray beams and often target diffraction-limited resolution. Therefore, their accurate simulation and modeling has to be performed within the framework of wave optics. Here the implementation and benchmarking of a wave-optics method for the simulation of grazing-incidence mirrors based on the local stationary-phase approximation or, in other words, the local propagation of the radiation electric field along geometrical rays, is described. The proposed method is CPU-efficient and fully compatible with the numerical methods of Fourier optics. It has been implemented in the Synchrotron Radiation Workshop (SRW) computer code and extensively tested against the geometrical ray-tracing code SHADOW. The test simulations have been performed for cases without and with diffraction at mirror apertures, including cases where the grazing-incidence mirrors can be hardly approximated by ideal lenses. Good agreement between the SRW and SHADOW simulation results is observed in the cases without diffraction. The differences between the simulation results obtained by the two codes in diffraction-dominated cases for illumination with fully or partially coherent radiation are analyzed and interpreted. The application of the new method for the simulation of wavefront propagation through a high-resolution X-ray microspectroscopy beamline at the National Synchrotron Light Source II (Brookhaven National Laboratory, USA) is demonstrated.

Intravascular Optical Imaging Technology for Investigating the Coronary Artery

PubMed Central

Suter, Melissa J.; Nadkarni, Seemantini K.; Weisz, Giora; Tanaka, Atsushi; Jaffer, Farouc A.; Bouma, Brett E.; Tearney, Guillermo J.

2012-01-01

There is an ever-increasing demand for new imaging methods that can provide additional information about the coronary wall to better characterize and stratify high-risk plaques, and to guide interventional and pharmacologic management of patients with coronary artery disease. While there are a number of imaging modalities that facilitate the assessment of coronary artery pathology, this review paper focuses on intravascular optical imaging modalities that provide information on the microstructural, compositional, biochemical, biomechanical, and molecular features of coronary lesions and stents. The optical imaging modalities discussed include angioscopy, optical coherence tomography, polarization sensitive-optical coherence tomography, laser speckle imaging, near-infrared spectroscopy, time-resolved laser induced fluorescence spectroscopy, Raman spectroscopy, and near-infrared fluorescence molecular imaging. Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in the evaluation of the coronary artery in the future. PMID:21920342

High collimated coherent illumination for reconstruction of digitally calculated holograms: design and experimental realization

NASA Astrophysics Data System (ADS)

Morozov, Alexander; Dubinin, German; Dubynin, Sergey; Yanusik, Igor; Kim, Sun Il; Choi, Chil-Sung; Song, Hoon; Lee, Hong-Seok; Putilin, Andrey; Kopenkin, Sergey; Borodin, Yuriy

2017-06-01

Future commercialization of glasses-free holographic real 3D displays requires not only appropriate image quality but also slim design of backlight unit and whole display device to match market needs. While a lot of research aimed to solve computational issues of forming Computer Generated Holograms for 3D Holographic displays, less focus on development of backlight units suitable for 3D holographic display applications with form-factor of conventional 2D display systems. Thereby, we report coherent backlight unit for 3D holographic display with thickness comparable to commercially available 2D displays (cell phones, tablets, laptops, etc.). Coherent backlight unit forms uniform, high-collimated and effective illumination of spatial light modulator. Realization of such backlight unit is possible due to holographic optical elements, based on volume gratings, constructing coherent collimated beam to illuminate display plane. Design, recording and measurement of 5.5 inch coherent backlight unit based on two holographic optical elements are presented in this paper.

Speckle noise attenuation in optical coherence tomography by compounding images acquired at different positions of the sample

NASA Astrophysics Data System (ADS)

Popescu, Dan P.; Hewko, Mark D.; Sowa, Michael G.

2007-01-01

This study demonstrates a simple method for attenuating the speckle noise generated by coherent multiple-scattered photons in optical-coherence tomography images. The method could be included among the space-diversity techniques used for speckle reduction. It relies on displacing the sample along a weakly focused beam in the sample arm of the interferometer, acquiring a coherent image for each sample position and adding the individual images to form a compounded image. It is proven that the compounded image displays a reduction in the speckle noise generated by multiple scattered photons and an enhancement in the intensity signal caused by single-backscattered photons. To evaluate its potential biomedical applications, the method is used to investigate in vitro a caries lesion affecting the enamel layer of a wisdom tooth. Because of the uncorrelated nature of the speckle noise the compounded image provides a better mapping of the lesion compared to a single (coherent) image.

Testing of Piezo-Actuated Glass Micro-Membranes by Optical Low-Coherence Reflectometry.

PubMed

Merlo, Sabina; Poma, Paolo; Crisà, Eleonora; Faralli, Dino; Soldo, Marco

2017-02-25

In this work, we have applied optical low-coherence reflectometry (OLCR), implemented with infra-red light propagating in fiberoptic paths, to perform static and dynamic analyses on piezo-actuated glass micro-membranes. The actuator was fabricated by means of thin-film piezoelectric MEMS technology and was employed for modifying the micro-membrane curvature, in view of its application in micro-optic devices, such as variable focus micro-lenses. We are here showing that OLCR incorporating a near-infrared superluminescent light emitting diode as the read-out source is suitable for measuring various parameters such as the micro-membrane optical path-length, the membrane displacement as a function of the applied voltage (yielding the piezo-actuator hysteresis) as well as the resonance curve of the fundamental vibration mode. The use of an optical source with short coherence-time allows performing interferometric measurements without spurious resonance effects due to multiple parallel interfaces of highly planar slabs, furthermore selecting the plane/layer to be monitored. We demonstrate that the same compact and flexible setup can be successfully employed to perform spot optical measurements for static and dynamic characterization of piezo-MEMS in real time.

Testing of Piezo-Actuated Glass Micro-Membranes by Optical Low-Coherence Reflectometry

PubMed Central

Merlo, Sabina; Poma, Paolo; Crisà, Eleonora; Faralli, Dino; Soldo, Marco

2017-01-01

In this work, we have applied optical low-coherence reflectometry (OLCR), implemented with infra-red light propagating in fiberoptic paths, to perform static and dynamic analyses on piezo-actuated glass micro-membranes. The actuator was fabricated by means of thin-film piezoelectric MEMS technology and was employed for modifying the micro-membrane curvature, in view of its application in micro-optic devices, such as variable focus micro-lenses. We are here showing that OLCR incorporating a near-infrared superluminescent light emitting diode as the read-out source is suitable for measuring various parameters such as the micro-membrane optical path-length, the membrane displacement as a function of the applied voltage (yielding the piezo-actuator hysteresis) as well as the resonance curve of the fundamental vibration mode. The use of an optical source with short coherence-time allows performing interferometric measurements without spurious resonance effects due to multiple parallel interfaces of highly planar slabs, furthermore selecting the plane/layer to be monitored. We demonstrate that the same compact and flexible setup can be successfully employed to perform spot optical measurements for static and dynamic characterization of piezo-MEMS in real time. PMID:28245603

Efficient modeling of Bragg coherent x-ray nanobeam diffraction

DOE PAGES

Hruszkewycz, S. O.; Holt, M. V.; Allain, M.; ...

2015-07-02

X-ray Bragg diffraction experiments that utilize tightly focused coherent beams produce complicated Bragg diffraction patterns that depend on scattering geometry, characteristics of the sample, and properties of the x-ray focusing optic. In this paper, we use a Fourier-transform-based method of modeling the 2D intensity distribution of a Bragg peak and apply it to the case of thin films illuminated with a Fresnel zone plate in three different Bragg scattering geometries. Finally, the calculations agree well with experimental coherent diffraction patterns, demonstrating that nanodiffraction patterns can be modeled at nonsymmetric Bragg conditions with this approach—a capability critical for advancing nanofocused x-raymore » diffraction microscopy.« less

Dynamic coherent backscattering mirror

NASA Astrophysics Data System (ADS)

Zeylikovich, I.; Xu, M.

2016-02-01

The phase of multiply scattered light has recently attracted considerable interest. Coherent backscattering is a striking phenomenon of multiple scattered light in which the coherence of light survives multiple scattering in a random medium and is observable in the direction space as an enhancement of the intensity of backscattered light within a cone around the retroreflection direction. Reciprocity also leads to enhancement of backscattering light in the spatial space. The random medium behaves as a reciprocity mirror which robustly converts a diverging incident beam into a converging backscattering one focusing at a conjugate spot in space. Here we first analyze theoretically this coherent backscattering mirror (CBM) phenomenon and then demonstrate the capability of CBM compensating and correcting both static and dynamic phase distortions occurring along the optical path. CBM may offer novel approaches for high speed dynamic phase corrections in optical systems and find applications in sensing and navigation.

Adiabatic Quantum Computation: Coherent Control Back Action.

PubMed

Goswami, Debabrata

2006-11-22

Though attractive from scalability aspects, optical approaches to quantum computing are highly prone to decoherence and rapid population loss due to nonradiative processes such as vibrational redistribution. We show that such effects can be reduced by adiabatic coherent control, in which quantum interference between multiple excitation pathways is used to cancel coupling to the unwanted, non-radiative channels. We focus on experimentally demonstrated adiabatic controlled population transfer experiments wherein the details on the coherence aspects are yet to be explored theoretically but are important for quantum computation. Such quantum computing schemes also form a back-action connection to coherent control developments.

Ronchi test for characterization of nanofocusing optics at a hard x-ray free-electron laser.

PubMed

Nilsson, Daniel; Uhlén, Fredrik; Holmberg, Anders; Hertz, Hans M; Schropp, Andreas; Patommel, Jens; Hoppe, Robert; Seiboth, Frank; Meier, Vivienne; Schroer, Christian G; Galtier, Eric; Nagler, Bob; Lee, Hae Ja; Vogt, Ulrich

2012-12-15

We demonstrate the use of the classical Ronchi test to characterize aberrations in focusing optics at a hard x-ray free-electron laser. A grating is placed close to the focus and the interference between the different orders after the grating is observed in the far field. Any aberrations in the beam or the optics will distort the interference fringes. The method is simple to implement and can provide single-shot information about the focusing quality. We used the Ronchi test to measure the aberrations in a nanofocusing Fresnel zone plate at the Linac Coherent Light Source at 8.194 keV.

Statistical parametric mapping of stimuli-evoked changes in quantitative blood flow using extended-focus optical coherence microscopy (Conference Presentation)

NASA Astrophysics Data System (ADS)

Marchand, Paul J.; Bouwens, Arno; Shamaei, Vincent; Nguyen, David; Extermann, Jerome; Bolmont, Tristan; Lasser, Theo

2016-03-01

Magnetic Resonance Imaging has revolutionised our understanding of brain function through its ability to image human cerebral structures non-invasively over the entire brain. By exploiting the different magnetic properties of oxygenated and deoxygenated blood, functional MRI can indirectly map areas undergoing neural activation. Alongside the development of fMRI, powerful statistical tools have been developed in an effort to shed light on the neural pathways involved in processing of sensory and cognitive information. In spite of the major improvements made in fMRI technology, the obtained spatial resolution of hundreds of microns prevents MRI in resolving and monitoring processes occurring at the cellular level. In this regard, Optical Coherence Microscopy is an ideal instrumentation as it can image at high spatio-temporal resolution. Moreover, by measuring the mean and the width of the Doppler spectra of light scattered by moving particles, OCM allows extracting the axial and lateral velocity components of red blood cells. The ability to assess quantitatively total blood velocity, as opposed to classical axial velocity Doppler OCM, is of paramount importance in brain imaging as a large proportion of cortical vascular is oriented perpendicularly to the optical axis. We combine here quantitative blood flow imaging with extended-focus Optical Coherence Microscopy and Statistical Parametric Mapping tools to generate maps of stimuli-evoked cortical hemodynamics at the capillary level.

The Atomic, Molecular and Optical Science instrument at the Linac Coherent Light Source

DOE PAGES

Ferguson, Ken R.; Bucher, Maximilian; Bozek, John D.; ...

2015-05-01

The Atomic, Molecular and Optical Science (AMO) instrument at the Linac Coherent Light Source (LCLS) provides a tight soft X-ray focus into one of three experimental endstations. The flexible instrument design is optimized for studying a wide variety of phenomena requiring peak intensity. There is a suite of spectrometers and two photon area detectors available. An optional mirror-based split-and-delay unit can be used for X-ray pump–probe experiments. Recent scientific highlights illustrate the imaging, time-resolved spectroscopy and high-power density capabilities of the AMO instrument.

Optical threshold secret sharing scheme based on basic vector operations and coherence superposition

NASA Astrophysics Data System (ADS)

Deng, Xiaopeng; Wen, Wei; Mi, Xianwu; Long, Xuewen

2015-04-01

We propose, to our knowledge for the first time, a simple optical algorithm for secret image sharing with the (2,n) threshold scheme based on basic vector operations and coherence superposition. The secret image to be shared is firstly divided into n shadow images by use of basic vector operations. In the reconstruction stage, the secret image can be retrieved by recording the intensity of the coherence superposition of any two shadow images. Compared with the published encryption techniques which focus narrowly on information encryption, the proposed method can realize information encryption as well as secret sharing, which further ensures the safety and integrality of the secret information and prevents power from being kept centralized and abused. The feasibility and effectiveness of the proposed method are demonstrated by numerical results.

Advanced optical fiber communication systems

NASA Astrophysics Data System (ADS)

Kazovsky, Leonid G.

1994-03-01

Our research is focused on three major aspects of advanced optical fiber communication systems: dynamic wavelength division multiplexing (WDM) networks, fiber nonlinearities, and high dynamic range coherent analog optical links. In the area of WDM networks, we have designed and implemented two high-speed interface boards and measured their throughput and latency. Furthermore, we designed and constructed an experimental PSK/ASK transceiver that simultaneously transmits packet-switched ASK data and circuit-switched PSK data on the same optical carrier. In the area of fiber nonlinearities, we investigated the theoretical impact of modulation frequency on cross-phase modulation (XPM) in dispersive fibers. In the area of high dynamic range coherent analog optical links, we developed theoretical expressions for the RF power transfer ratio (or RF power gain) and the noise figure (NF) of angle-modulated links. We then compared the RF power gains and noise figures of these links to that of an intensity modulated direct detection (DD) link.

Pulse-encoded ultrasound imaging of the vitreous with an annular array.

PubMed

Silverman, Ronald H; Ketterling, Jeffrey A; Mamou, Jonathan; Lloyd, Harriet O; Filoux, Erwan; Coleman, D Jackson

2012-01-01

The vitreous body is nearly transparent both optically and ultrasonically. Conventional 10- to 12-MHz diagnostic ultrasound can detect vitreous inhomogeneities at high gain settings, but has limited resolution and sensitivity, especially outside the fixed focal zone near the retina. To improve visualization of faint intravitreal fluid/gel interfaces, the authors fabricated a spherically curved 20-MHz five-element annular array ultrasound transducer, implemented a synthetic-focusing algorithm to extend the depth-of-field, and used a pulse-encoding strategy to increase sensitivity. The authors evaluated a human subject with a recent posterior vitreous detachment and compared the annular array with conventional 10-MHz ultrasound and spectral-domain optical coherence tomography. With synthetic focusing and chirp pulse-encoding, the array allowed visualization of the formed and fluid components of the vitreous with improved sensitivity and resolution compared with the conventional B-scan. Although optical coherence tomography allowed assessment of the posterior vitreoretinal interface, the ultrasound array allowed evaluation of the entire vitreous body. Copyright 2012, SLACK Incorporated.

Optics for coherent X-ray applications

PubMed Central

Yabashi, Makina; Tono, Kensuke; Mimura, Hidekazu; Matsuyama, Satoshi; Yamauchi, Kazuto; Tanaka, Takashi; Tanaka, Hitoshi; Tamasaku, Kenji; Ohashi, Haruhiko; Goto, Shunji; Ishikawa, Tetsuya

2014-01-01

Developments of X-ray optics for full utilization of diffraction-limited storage rings (DLSRs) are presented. The expected performance of DLSRs is introduced using the design parameters of SPring-8 II. To develop optical elements applicable to manipulation of coherent X-rays, advanced technologies on precise processing and metrology were invented. With propagation-based coherent X-rays at the 1 km beamline of SPring-8, a beryllium window fabricated with the physical-vapour-deposition method was found to have ideal speckle-free properties. The elastic emission machining method was utilized for developing reflective mirrors without distortion of the wavefronts. The method was further applied to production of diffraction-limited focusing mirrors generating the smallest spot size in the sub-10 nm regime. To enable production of ultra-intense nanobeams at DLSRs, a low-vibration cooling system for a high-heat-load monochromator and advanced diagnostic systems to characterize X-ray beam properties precisely were developed. Finally, new experimental schemes for combinative nano-analysis and spectroscopy realised with novel X-ray optics are discussed. PMID:25177986

Dependence on fiber Fabry-Pérot tunable filter characteristics in an all-fiber swept-wavelength laser for use in an optical coherence tomography system

NASA Astrophysics Data System (ADS)

Stay, Justin L.; Carr, Dustin; Ferguson, Steve; Haber, Todd; Jenkins, Robert; Mock, Joel

2017-02-01

Optical coherence tomography (OCT) has become a useful and common diagnostic tool within the field of ophthalmology. Although presently a commercial technology, research continues in improving image quality and applying the imaging method to other tissue types. Swept-wavelength lasers based upon fiber ring cavities containing fiber Fabry-Ṕerot tunable filters (FFP-TF), as an intracavity element, provide swept-source optical coherence tomography (SS-OCT) systems with a robust and scalable platform. The FFP-TF can be fabricated within a large range of operating wavelengths, free spectral ranges (FSR), and finesses. To date, FFP-TFs have been fabricated at operating wavelengths from 400 nm to 2.2 µm, FSRs as large as 45 THz, and finesses as high as 30 000. The results in this paper focus on presenting the capability of the FFP-TF as an intracavity element in producing swept-wavelength lasers sources and quantifying the trade off between coherence length and sweep range. We present results within a range of feasible operating conditions. Particular focus is given to the discovery of laser configurations that result in maximization of sweep range and/or power. A novel approach to the electronic drive of the PZT-based FFP-TF is also presented, which eliminates the need for the existence of a mechanical resonance of the optical device. This approach substantially increases the range of drive frequencies with which the filter can be driven and has a positive impact for both the short all-fiber laser cavity (presented in this paper) and long cavity FDML designs as well.

Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography.

PubMed

Oh, Junghwan; Feldman, Marc D; Kim, Jihoon; Kang, Hyun Wook; Sanghi, Pramod; Milner, Thomas E

2007-03-01

A novel method to detect tissue-based macrophages using a combination of superparamagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field. (c) 2007 Wiley-Liss, Inc

Experimental generation of optical coherence lattices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yahong; Cai, Yangjian, E-mail: serpo@dal.ca, E-mail: yangjiancai@suda.edu.cn; Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province and Key Lab of Modern Optical Technologies of Education Ministry of China, Soochow University, Suzhou 215006

2016-08-08

We report experimental generation and measurement of recently introduced optical coherence lattices. The presented optical coherence lattice realization technique hinges on a superposition of mutually uncorrelated partially coherent Schell-model beams with tailored coherence properties. We show theoretically that information can be encoded into and, in principle, recovered from the lattice degree of coherence. Our results can find applications to image transmission and optical encryption.

An alternative theoretical model for an anomalous hollow beam.

PubMed

Cai, Yangjian; Wang, Zhaoying; Lin, Qiang

2008-09-15

An alternative and convenient theoretical model is proposed to describe a flexible anomalous hollow beam of elliptical symmetry with an elliptical solid core, which was observed in experiment recently (Phys. Rev. Lett, 94 (2005) 134802). In this model, the electric field of anomalous hollow beam is expressed as a finite sum of elliptical Gaussian modes. Flattopped beams, dark hollow beams and Gaussian beams are special cases of our model. Analytical propagation formulae for coherent and partially coherent anomalous hollow beams passing through astigmatic ABCD optical systems are derived. Some numerical examples are calculated to show the propagation and focusing properties of coherent and partially coherent anomalous hollow beams.

Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography

NASA Astrophysics Data System (ADS)

Herz, P. R.; Chen, Y.; Aguirre, A. D.; Schneider, K.; Hsiung, P.; Fujimoto, J. G.; Madden, K.; Schmitt, J.; Goodnow, J.; Petersen, C.

2004-10-01

A distally actuated, rotational-scanning micromotor endoscope catheter probe is demonstrated for ultrahigh-resolution in vivo endoscopic optical coherence tomography (OCT) imaging. The probe permits focus adjustment for visualization of tissue morphology at varying depths with improved transverse resolution compared with standard OCT imaging probes. The distal actuation avoids nonuniform scanning motion artifacts that are present with other probe designs and can permit a wider range of imaging speeds. Ultrahigh-resolution endoscopic imaging is demonstrated in a rabbit with <4-µm axial resolution by use of a femtosecond Crforsterite laser light source. The micromotor endoscope catheter probe promises to improve OCT imaging performance in future endoscopic imaging applications.

Coherent and incoherent combination of Gaussian beams employing lens array distributed on the spherical chamber.

PubMed

Huang, Zhihua; Wei, Xiaofeng; Li, Mingzhong; Wang, Jianjun; Lin, Honghuan; Xu, Dangpeng; Deng, Ying; Zhang, Rui

2012-04-01

Coherent and incoherent combination of Gaussian beams employing a lens array distributed on the spherical chamber is theoretically analyzed. The output field of each source in the array is coupled through an individual optical system whose local optical axis coincides with the radial direction of the chamber. The resulting intensity profile near the origin is derived. The intensity profile and power in the bucket on the target for rectangular and hexagonal arrangement are numerically calculated. The influences of the center-to-center separation and the ring number of the focusing lens array are given. The synthetic intensity profile of incoherent combination changes little for a lens array scale much smaller than the chamber size. In contrast, the synthetic intensity profile of coherent combination shows an interference pattern with a sharp central peak and sidelobes.

Coupling of erbium dopants to yttrium orthosilicate photonic crystal cavities for on-chip optical quantum memories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miyazono, Evan; Zhong, Tian; Craiciu, Ioana

Erbium dopants in crystals exhibit highly coherent optical transitions well suited for solid-state optical quantum memories operating in the telecom band. Here, we demonstrate coupling of erbium dopant ions in yttrium orthosilicate to a photonic crystal cavity fabricated directly in the host crystal using focused ion beam milling. The coupling leads to reduction of the photoluminescence lifetime and enhancement of the optical depth in microns-long devices, which will enable on-chip quantum memories.

Coherent x-ray diffraction imaging with nanofocused illumination.

PubMed

Schroer, C G; Boye, P; Feldkamp, J M; Patommel, J; Schropp, A; Schwab, A; Stephan, S; Burghammer, M; Schöder, S; Riekel, C

2008-08-29

Coherent x-ray diffraction imaging is an x-ray microscopy technique with the potential of reaching spatial resolutions well beyond the diffraction limits of x-ray microscopes based on optics. However, the available coherent dose at modern x-ray sources is limited, setting practical bounds on the spatial resolution of the technique. By focusing the available coherent flux onto the sample, the spatial resolution can be improved for radiation-hard specimens. A small gold particle (size <100 nm) was illuminated with a hard x-ray nanobeam (E=15.25 keV, beam dimensions approximately 100 x 100 nm2) and is reconstructed from its coherent diffraction pattern. A resolution of about 5 nm is achieved in 600 s exposure time.

Entanglement of Multi-qudit States Constructed by Linearly Independent Coherent States: Balanced Case

NASA Astrophysics Data System (ADS)

Najarbashi, G.; Mirzaei, S.

2016-03-01

Multi-mode entangled coherent states are important resources for linear optics quantum computation and teleportation. Here we introduce the generalized balanced N-mode coherent states which recast in the multi-qudit case. The necessary and sufficient condition for bi-separability of such balanced N-mode coherent states is found. We particularly focus on pure and mixed multi-qubit and multi-qutrit like states and examine the degree of bipartite as well as tripartite entanglement using the concurrence measure. Unlike the N-qubit case, it is shown that there are qutrit states violating monogamy inequality. Using parity, displacement operator and beam splitters, we will propose a scheme for generating balanced N-mode entangled coherent states for even number of terms in superposition.

Toward a low-cost, low-power, low-complexity DAC-based multilevel (M-ary QAM) coherent transmitter using compact linear optical field modulator

NASA Astrophysics Data System (ADS)

Dingel, Benjamin

2017-01-01

In this invited paper, we summarize the current developments in linear optical field modulators (LOFMs) for coherent multilevel optical transmitters. Our focus is the presentation of a new, novel LOFM design that provides beneficial and necessary features such as lowest hardware component counts, lowered insertion loss, smaller RF power consumption, smaller footprint, simple structure, and lowered cost. We refer to this modulator as called Double-Pass LOFM (DP-LOFM) that becomes the building block for high-performance, linear Dual-Polarization, In-Phase- Quadrature-Phase (DP-IQ) modulator. We analyze its performance in term of slope linearity, and present one of its unique feature -- a built-in compensation functionality that no other linear modulators possessed till now.

Coherent/Noncoherent Detection of Coherent Optical Heterodyne DPSK-CDMA and MFSK-CDMA Signals

DTIC Science & Technology

1991-12-01

AD-A246 215 NAVAL POSTGRADUATE SCHOOL Monterey, Californla DTI THESIS COHERENT/ NONCOHERENT DETECTION OF COHERENT OPTICAL HETERODYNE DPSK-CDMA AND...NO ~ ACCESSION NO 11TILE(ncud S~riy ~a~fiat~r)COHERENT/ NONCOHERENT DETECTION OF COHERENT OPTICAL HETERODYNE DPSK-CDMA AND MFSK-CDMA SIGNALS 12 PERSONAL...early optical fiber communication systems. Gas lasers are also disregarded for practical systems due to size and safety considerations, even though

Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus optical coherence microscopy

NASA Astrophysics Data System (ADS)

Tamborski, Szymon; Lyu, Hong Chou; Bukowska, Danuta; Dolezyczek, Hubert; Wilczynski, Grzegorz; Szlag, Daniel; Lasser, Theo; Wojtkowski, Maciej; Szkulmowski, Maciej

2016-03-01

We used Optical Coherence Microscopy (OCM) to monitor structural and functional changes due to ischemic stroke in small animals brains in vivo. To obtain lateral resolution of 2.2 μm over the range of 600 μm we used extended focus configuration of OCM instrument involving Bessel beam. It provided access to detailed 3D information about the changes in brain vascular system up to the level of capillaries across I and II/III layers of neocortex. We used photothrombotic stroke model involving photoactive application of rose bengal to assure minimal invasiveness of the procedure and precise localization of the clot distribution center. We present the comparative analysis involving structural and angiographic maps of the stroke-affected brain enabling in-depth insight to the process of development of the disorder.

Optical diffraction tomography with fully and partially coherent illumination in high numerical aperture label-free microscopy [Invited].

PubMed

Soto, Juan M; Rodrigo, José A; Alieva, Tatiana

2018-01-01

Quantitative label-free imaging is an important tool for the study of living microorganisms that, during the last decade, has attracted wide attention from the optical community. Optical diffraction tomography (ODT) is probably the most relevant technique for quantitative label-free 3D imaging applied in wide-field microscopy in the visible range. The ODT is usually performed using spatially coherent light illumination and specially designed holographic microscopes. Nevertheless, the ODT is also compatible with partially coherent illumination and can be realized in conventional wide-field microscopes by applying refocusing techniques, as it has been recently demonstrated. Here, we compare these two ODT modalities, underlining their pros and cons and discussing the optical setups for their implementation. In particular, we pay special attention to a system that is compatible with a conventional wide-field microscope that can be used for both ODT modalities. It consists of two easily attachable modules: the first for sample illumination engineering based on digital light processing technology; the other for focus scanning by using an electrically driven tunable lens. This hardware allows for a programmable selection of the wavelength and the illumination design, and provides fast data acquisition as well. Its performance is experimentally demonstrated in the case of ODT with partially coherent illumination providing speckle-free 3D quantitative imaging.

Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 cm in thickness with digital optical phase conjugation

NASA Astrophysics Data System (ADS)

Shen, Yuecheng; Liu, Yan; Ma, Cheng; Wang, Lihong V.

2016-08-01

Optical phase conjugation (OPC)-based wavefront shaping techniques focus light through or within scattering media, which is critically important for deep-tissue optical imaging, manipulation, and therapy. However, to date, the sample thickness in OPC experiments has been limited to only a few millimeters. Here, by using a laser with a long coherence length and an optimized digital OPC system that can safely deliver more light power, we focused 532-nm light through tissue-mimicking phantoms up to 9.6 cm thick, as well as through ex vivo chicken breast tissue up to 2.5 cm thick. Our results demonstrate that OPC can be achieved even when photons have experienced on average 1000 scattering events. The demonstrated penetration of nearly 10 cm (˜100 transport mean free paths) has never been achieved before by any optical focusing technique, and it shows the promise of OPC for deep-tissue noninvasive optical imaging, manipulation, and therapy.

Rejuvenating direct modulation and direct detection for modern optical communications

NASA Astrophysics Data System (ADS)

Che, Di; Li, An; Chen, Xi; Hu, Qian; Shieh, William

2018-02-01

High-speed transoceanic optical fiber transmission using direct modulation (DM) and direct detection (DD) was one of the most stirring breakthroughs for telecommunication in 1990s, which drove the internet as a global phenomenon. However, the later evolution of optical coherent communications in 2000s gradually took over the long-haul applications, due to its superior optical spectral efficiency. Nowadays, DM-DD systems are dominant mainly in cost- and power-sensitive short-reach applications, because of its natural characteristics-the simplicity. This paper reviews the recent advances of DM-DD transceivers from both hardware and signal processing perspectives. It introduces a variety of modified DM and/or DD systems for 3 application scenarios: very-short-reach interconnect with little fiber channel impact; single or a few spans of fiber transmission up to several hundred km; and distance beyond the 2nd scenario. Besides the DM-DD and multi-dimension DM-DD with polarization diversity, this paper focuses on how to rejuvenate traditional DM and DD technologies in order to bridge the transmission application gap between DM-DD and coherent transceivers, using technologies such as dispersion compensation, signal field recovery from the intensity-only DD receiver, and complex direct modulation with coherent detection. More than 30 years since the birth, DM and DD still hold indispensable roles in modern optical communications.

Ultra-compact swept-source optical coherence tomography handheld probe with motorized focus adjustment (Conference Presentation)

NASA Astrophysics Data System (ADS)

LaRocca, Francesco; Nankivil, Derek; Keller, Brenton; Farsiu, Sina; Izatt, Joseph A.

2017-02-01

Handheld optical coherence tomography (OCT) systems facilitate imaging of young children, bedridden subjects, and those with less stable fixation. Smaller and lighter OCT probes allow for more efficient imaging and reduced operator fatigue, which is critical for prolonged use in either the operating room or neonatal intensive care unit. In addition to size and weight, the imaging speed, image quality, field of view, resolution, and focus correction capability are critical parameters that determine the clinical utility of a handheld probe. Here, we describe an ultra-compact swept source (SS) OCT handheld probe weighing only 211 g (half the weight of the next lightest handheld SSOCT probe in the literature) with 20.1 µm lateral resolution, 7 µm axial resolution, 102 dB peak sensitivity, a 27° x 23° field of view, and motorized focus adjustment for refraction correction between -10 to +16 D. A 2D microelectromechanical systems (MEMS) scanner, a converging beam-at-scanner telescope configuration, and an optical design employing 6 different custom optics were used to minimize device size and weight while achieving diffraction limited performance throughout the system's field of view. Custom graphics processing unit (GPU)-accelerated software was used to provide real-time display of OCT B-scans and volumes. Retinal images were acquired from adult volunteers to demonstrate imaging performance.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeylikovich, I.; Xu, M., E-mail: mxu@fairfield.edu

The phase of multiply scattered light has recently attracted considerable interest. Coherent backscattering is a striking phenomenon of multiple scattered light in which the coherence of light survives multiple scattering in a random medium and is observable in the direction space as an enhancement of the intensity of backscattered light within a cone around the retroreflection direction. Reciprocity also leads to enhancement of backscattering light in the spatial space. The random medium behaves as a reciprocity mirror which robustly converts a diverging incident beam into a converging backscattering one focusing at a conjugate spot in space. Here we first analyzemore » theoretically this coherent backscattering mirror (CBM) phenomenon and then demonstrate the capability of CBM compensating and correcting both static and dynamic phase distortions occurring along the optical path. CBM may offer novel approaches for high speed dynamic phase corrections in optical systems and find applications in sensing and navigation.« less

Endoscopic optical coherence tomography: technologies and clinical applications [Invited

PubMed Central

Gora, Michalina J.; Suter, Melissa J.; Tearney, Guillermo J.; Li, Xingde

2017-01-01

In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. PMID:28663882

Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography.

PubMed

Herz, P R; Chen, Y; Aguirre, A D; Schneider, K; Hsiung, P; Fujimoto, J G; Madden, K; Schmitt, J; Goodnow, J; Petersen, C

2004-10-01

A distally actuated, rotational-scanning micromotor endoscope catheter probe is demonstrated for ultrahigh-resolution in vivo endoscopic optical coherence tomography (OCT) imaging. The probe permits focus adjustment for visualization of tissue morphology at varying depths with improved transverse resolution compared with standard OCT imaging probes. The distal actuation avoids nonuniform scanning motion artifacts that are present with other probe designs and can permit a wider range of imaging speeds. Ultrahigh-resolution endoscopic imaging is demonstrated in a rabbit with <4-microm axial resolution by use of a femtosecond Cr:forsterite laser light source. The micromotor endoscope catheter probe promises to improve OCT imaging performance in future endoscopic imaging applications.

Comparison of qubit and qutrit like entangled squeezed and coherent states of light

NASA Astrophysics Data System (ADS)

Najarbashi, G.; Mirzaei, S.

2016-10-01

Squeezed state of light is one of the important subjects in quantum optics which is generated by optical nonlinear interactions. In this paper, we especially focus on qubit like entangled squeezed states (ESS's) generated by beam splitters, phase-shifter and cross Kerr nonlinearity. Moreover the Wigner function of two-mode qubit and qutrit like ESS are investigated. We will show that the distances of peaks of Wigner functions for two-mode ESS are entanglement sensitive and can be a witness for entanglement. Like the qubit cases, monogamy inequality is fulfilled for qutrit like ESS. These trends are compared with those obtained for qubit and qutrit like entangled coherent states (ECS).

Emerging Connections: Quantum & Classical Optics Incubator Program Book

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lesky, Marcia

The Emerging Connections: Quantum & Classical Optics Incubator was a scientific meeting held in Washington, DC on 6-8 November 2016. This Incubator provided unique and focused experiences and valuable opportunities to discuss advances, challenges and opportunities regarding this important area of research. Quantum optics and classical optics have coexisted for nearly a century as two distinct, but consistent descriptions of light in their respective domains. Recently, a number of detailed examinations of the structure of classical light beams have revealed that effects widely thought to be solely quantum in origin also have a place in classical optics. These new quantum-classicalmore » connections are informing classical optics in meaningful ways specifically by expanding understanding of optical coherence. Simultaneously, relationships discovered with classical light beams now also serve as a vehicle to illuminate concepts that no longer solely belong to the quantum realm. Interference, polarization, coherence, complementarity and entanglement are a partial list of elementary notions that now appear to belong to both quantum and classical optics. The goal of this meeting was to bring emerging quantum-classical links into wider view and to indicate directions in which forthcoming and future work would promote discussion and lead to a more unified understanding of optics.« less

EDITORIAL: Recent developments in biomedical optics

NASA Astrophysics Data System (ADS)

Wang, Ruikang K.; Hebden, Jeremy C.; Tuchin, Valery V.

2004-04-01

The rapid growth in laser and photonic technology has resulted in new tools being proposed and developed for use in the medical and biological sciences. Specifically, a discipline known as biomedical optics has emerged which is providing a broad variety of optical techniques and instruments for diagnostic, therapeutic and basic science applications. New laser sources, detectors and measurement techniques are yielding powerful new methods for the study of diseases on all scales, from single molecules, to specific tissues and whole organs. For example, novel laser microscopes permit spectroscopic and force measurements to be performed on single protein molecules; new optical devices provide information on molecular dynamics and structure to perform `optical biopsy' non-invasively and almost instantaneously; and optical coherence tomography and diffuse optical tomography allow visualization of specific tissues and organs. Using genetic promoters to derive luciferase expression, bioluminescence methods can generate molecular light switches, which serve as functional indicator lights reporting cellular conditions and responses in living animals. This technique could allow rapid assessment of and response to the effects of anti-tumour drugs, antibiotics, or antiviral drugs. This issue of Physics in Medicine and Biology highlights recent research in biomedical optics, and is based on invited contributions to the International Conference on Advanced Laser Technology (Focused on Biomedical Optics) held at Cranfield University at Silsoe on 19--23 September 2003. This meeting included sessions devoted to: diffuse optical imaging and spectroscopy; optical coherence tomography and coherent domain techniques; optical sensing and applications in life science; microscopic, spectroscopic and opto-acoustic imaging; therapeutic and diagnostic applications; and laser interaction with organic and inorganic materials. Twenty-one papers are included in this special issue. The first paper gives an overview on the current status of scanning laser ophthalmoscopy and its role in bioscience and medicine, while the second paper describes the current problems in tissue engineering and the potential role for optical coherence tomography. The following seven papers present and discuss latest developments in infrared spectroscopy and diffuse optical tomography for medical diagnostics. Eight further papers report recent advances in optical coherence tomography, covering new and evolving methods and instrumentation, theoretical and numerical modelling, and its clinical applications. The remaining papers cover miscellaneous topics in biomedical optics, including new developments in opto-acoustic imaging techniques, laser speckle imaging of blood flow in microcirculations, and potential of hollow-core photonic-crystal fibres for laser dentistry. We thank all the authors for their valuable contributions and their prompt responses to reviewers' comments. We are also very grateful to the reviewers for their hard work and their considerable efforts to meet tight deadlines.

Partially coherent lensfree tomographic microscopy⋄

PubMed Central

Isikman, Serhan O.; Bishara, Waheb; Ozcan, Aydogan

2012-01-01

Optical sectioning of biological specimens provides detailed volumetric information regarding their internal structure. To provide a complementary approach to existing three-dimensional (3D) microscopy modalities, we have recently demonstrated lensfree optical tomography that offers high-throughput imaging within a compact and simple platform. In this approach, in-line holograms of objects at different angles of partially coherent illumination are recorded using a digital sensor-array, which enables computing pixel super-resolved tomographic images of the specimen. This imaging modality, which forms the focus of this review, offers micrometer-scale 3D resolution over large imaging volumes of, for example, 10–15 mm3, and can be assembled in light weight and compact architectures. Therefore, lensfree optical tomography might be particularly useful for lab-on-a-chip applications as well as for microscopy needs in resource-limited settings. PMID:22193016

Nanophotonic photon echo memory based on rare-earth-doped crystals

NASA Astrophysics Data System (ADS)

Zhong, Tian; Kindem, Jonathan; Miyazono, Evan; Faraon, Andrei; Caltech nano quantum optics Team

2015-03-01

Rare earth ions (REIs) are promising candidates for implementing solid-state quantum memories and quantum repeater devices. Their high spectral stability and long coherence times make REIs a good choice for integration in an on-chip quantum nano-photonic platform. We report the coupling of the 883 nm transition of Neodymium (Nd) to a Yttrium orthosilicate (YSO) photonic crystal nano-beam resonator, achieving Purcell enhanced spontaneous emission by 21 times and increased optical absorption. Photon echoes were observed in nano-beams of different doping concentrations, yielding optical coherence times T2 up to 80 μs that are comparable to unprocessed bulk samples. This indicates the remarkable coherence properties of Nd are preserved during nanofabrication, therefore opening the possibility of efficient on-chip optical quantum memories. The nano-resonator with mode volume of 1 . 6(λ / n) 3 was fabricated using focused ion beam, and a quality factor of 3200 was measured. Purcell enhanced absorption of 80% by an ensemble of ~ 1 × 106 ions in the resonator was measured, which fulfills the cavity impedance matching condition that is necessary to achieve quantum storage of photons with unity efficiency.

Geometrical Reasoning in Wave Situations: The Case of Light Diffraction and Coherent Illumination Optical Imaging

ERIC Educational Resources Information Center

Maurines, Laurence

2010-01-01

This particular study is part of a research programme on the difficulties encountered by students when learning about wave phenomena in a three-dimensional medium in the absence or presence of obstacles. It focuses on how students reason in situations in which wave optics need to be used: diffraction of light by an aperture, imaging in the…

MULTIMODAL IMAGING OF ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPY.

PubMed

Skondra, Dimitra; Nesper, Peter L; Fawzi, Amani A

2017-05-16

To report a case of acute exudative polymorphous vitelliform maculopathy including the findings of optical coherence tomography angiography and adaptive optics scanning laser ophthalmoscopy. Findings on clinical examination, color fundus photography, spectral-domain optical coherence tomography, infrared reflectance, autofluorescence, optical coherence tomography angiography, and adaptive optics scanning laser ophthalmoscopy. A 54-year-old white man with no significant medical history and history of smoking presented with bilateral multiple serous and vitelliform detachments consistent with acute exudative polymorphous vitelliform maculopathy. Extensive infectious, inflammatory, and malignancy workup was negative. Spectral-domain optical coherence tomography showed thickened, hyperreflective ellipsoid zone, subretinal fluid, and focal as well as diffuse subretinal hyperreflective material corresponding to the vitelliform lesions. Optical coherence tomography angiography showed normal retinal and choroidal vasculature, whereas adaptive optics scanning laser ophthalmoscopy showed circular focal "target" lesions at the level of the photoreceptors in the area of foveal detachment. Multimodal imaging is valuable in evaluating patients with acute exudative polymorphous vitelliform maculopathy.

Phase noise suppression for coherent optical block transmission systems: a unified framework.

PubMed

Yang, Chuanchuan; Yang, Feng; Wang, Ziyu

2011-08-29

A unified framework for phase noise suppression is proposed in this paper, which could be applied in any coherent optical block transmission systems, including coherent optical orthogonal frequency-division multiplexing (CO-OFDM), coherent optical single-carrier frequency-domain equalization block transmission (CO-SCFDE), etc. Based on adaptive modeling of phase noise, unified observation equations for different coherent optical block transmission systems are constructed, which lead to unified phase noise estimation and suppression. Numerical results demonstrate that the proposal is powerful in mitigating laser phase noise.

Coherent time-stretch transformation for real-time capture of wideband signals.

PubMed

Buckley, Brandon W; Madni, Asad M; Jalali, Bahram

2013-09-09

Time stretch transformation of wideband waveforms boosts the performance of analog-to-digital converters and digital signal processors by slowing down analog electrical signals before digitization. The transform is based on dispersive Fourier transformation implemented in the optical domain. A coherent receiver would be ideal for capturing the time-stretched optical signal. Coherent receivers offer improved sensitivity, allow for digital cancellation of dispersion-induced impairments and optical nonlinearities, and enable decoding of phase-modulated optical data formats. Because time-stretch uses a chirped broadband (>1 THz) optical carrier, a new coherent detection technique is required. In this paper, we introduce and demonstrate coherent time stretch transformation; a technique that combines dispersive Fourier transform with optically broadband coherent detection.

Gabor domain optical coherence microscopy

NASA Astrophysics Data System (ADS)

Murali, Supraja

Time domain Optical Coherence Tomography (TD-OCT), first reported in 1991, makes use of the low temporal coherence properties of a NIR broadband laser to create depth sectioning of up to 2mm under the surface using optical interferometry and point to point scanning. Prior and ongoing work in OCT in the research community has concentrated on improving axial resolution through the development of broadband sources and speed of image acquisition through new techniques such as Spectral domain OCT (SD-OCT). In SD-OCT, an entire depth scan is acquired at once with a low numerical aperture (NA) objective lens focused at a fixed point within the sample. In this imaging geometry, a longer depth of focus is achieved at the expense of lateral resolution, which is typically limited to 10 to 20 mum. Optical Coherence Microscopy (OCM), introduced in 1994, combined the advantages of high axial resolution obtained in OCT with high lateral resolution obtained by increasing the NA of the microscope placed in the sample arm. However, OCM presented trade-offs caused by the inverse quadratic relationship between the NA and the DOF of the optics used. For applications requiring high lateral resolution, such as cancer diagnostics, several solutions have been proposed including the periodic manual re-focusing of the objective lens in the time domain as well as the spectral domain C-mode configuration in order to overcome the loss in lateral resolution outside the DOF. In this research, we report for the first time, high speed, sub-cellular imaging (lateral resolution of 2 mum) in OCM using a Gabor domain image processing algorithm with a custom designed and fabricated dynamic focus microscope interfaced to a Ti:Sa femtosecond laser centered at 800 nm within an SD-OCM configuration. It is envisioned that this technology will provide a non-invasive replacement for the current practice of multiple biopsies for skin cancer diagnosis. The research reported here presents three important advances to this technology all of which have been demonstrated in full functional hardware conceived and built during the course of this research. First, it has been demonstrated that the coherence gate created by the femtosecond laser can be coupled into a scanning optical microscope using optical design methods to include liquid lens technology that enables scanning below the surface of skin with no moving parts and at high resolution throughout a 2x2x2 mm imaging cube. Second, the integration the variable-focus liquid lens technology within a fixed-optics microscope custom optical design helped increase the working NA by an order of magnitude over the limitation imposed by the liquid lens alone. Thus, this design has enabled homogenous axial and lateral resolution at the micron-level (i.e., 2 mum) while imaging in the spectral domain, and still maintaining in vivo speeds. The latest images in biological specimens clearly demonstrate sub-cellular resolution in all dimensions throughout the imaging volume. Third, this new modality for data collection has been integrated with an automated Gabor domain image registration and fusion algorithm to provide full resolution images across the data cube in real-time. We refer to this overall OCM method as Gabor domain OCM (GD-OCM). These advantages place GD-OCM in a unique position with respect to the diagnosis of cancer, because when fully developed, it promises to enable fast and accurate screening for early symptoms that could lead to prevention. The next step for this technology is to apply it directly, in a clinical environment. This step is underway and is expected to be reported by the next generation of researchers within this group.

Coherence degree of the fundamental Bessel-Gaussian beam in turbulent atmosphere

NASA Astrophysics Data System (ADS)

Lukin, Igor P.

2017-11-01

In this article the coherence of a fundamental Bessel-Gaussian optical beam in turbulent atmosphere is analyzed. The problem analysis is based on the solution of the equation for the transverse second-order mutual coherence function of a fundamental Bessel-Gaussian optical beam of optical radiation. The behavior of a coherence degree of a fundamental Bessel-Gaussian optical beam depending on parameters of an optical beam and characteristics of turbulent atmosphere is examined. It was revealed that at low levels of fluctuations in turbulent atmosphere the coherence degree of a fundamental Bessel-Gaussian optical beam has the characteristic oscillating appearance. At high levels of fluctuations in turbulent atmosphere the coherence degree of a fundamental Bessel-Gaussian optical beam is described by an one-scale decreasing curve which in process of increase of level of fluctuations on a line of formation of a laser beam becomes closer to the same characteristic of a spherical optical wave.

Coherence of the vortex Bessel-Gaussian beam in turbulent atmosphere

NASA Astrophysics Data System (ADS)

Lukin, Igor P.

2017-11-01

In this paper the theoretical research of coherent properties of the vortex Bessel-Gaussian optical beams propagating in turbulent atmosphere are developed. The approach to the analysis of this problem is based on the analytical solution of the equation for the transverse second-order mutual coherence function of a field of optical radiation. The behavior of integral scale of coherence degree of vortex Bessel-Gaussian optical beams depending on parameters of an optical beam and characteristics of turbulent atmosphere is particularly considered. It is shown that the integral scale of coherence degree of a vortex Bessel-Gaussian optical beam essentially depends on value of a topological charge of a vortex optical beam. With increase in a topological charge of a vortex Bessel-Gaussian optical beam the value of integral scale of coherence degree of a vortex Bessel-Gaussian optical beam are decreased.

The New Physical Optics Notebook: Tutorials in Fourier Optics.

ERIC Educational Resources Information Center

Reynolds, George O.; And Others

This is a textbook of Fourier optics for the classroom or self-study. Major topics included in the 38 chapters are: Huygens' principle and Fourier transforms; image formation; optical coherence theory; coherent imaging; image analysis; coherent noise; interferometry; holography; communication theory techniques; analog optical computing; phase…

MOEMS optical delay line for optical coherence tomography

NASA Astrophysics Data System (ADS)

Choudhary, Om P.; Chouksey, S.; Sen, P. K.; Sen, P.; Solanki, J.; Andrews, J. T.

2014-09-01

Micro-Opto-Electro-Mechanical optical coherence tomography, a lab-on-chip for biomedical applications is designed, studied, fabricated and characterized. To fabricate the device standard PolyMUMPS processes is adopted. We report the utilization of electro-optic modulator for a fast scanning optical delay line for time domain optical coherence tomography. Design optimization are performed using Tanner EDA while simulations are performed using COMSOL. The paper summarizes various results and fabrication methodology adopted. The success of the device promises a future hand-held or endoscopic optical coherence tomography for biomedical applications.

Noncoherent Combination Of Optical-Heterodyne Outputs

NASA Technical Reports Server (NTRS)

Chen, Chien-Chung; Lesh, James R.

1990-01-01

In proposed scheme for reception of amplitude- or frequency-modulated signals transmitted optically through atmosphere, main receiver aperture divided into subapertures equipped with receivers, and outputs of receivers combined noncoherently. Multiple subaperture receivers used instead of attempting to focus all light from single large aperture onto one receiver. Outputs of receivers combined after demodulation. System will not perform as well as fully coherent system, but surpasses single-large-aperture system in presence of atmospheric turbulence. Offers superior performance in presence of distorted wavefront and/or imperfect receiver optics.

Development of Extended-Depth Swept Source Optical Coherence Tomography for Applications in Ophthalmic Imaging of the Anterior and Posterior Eye

NASA Astrophysics Data System (ADS)

Dhalla, Al-Hafeez Zahir

Optical coherence tomography (OCT) is a non-invasive optical imaging modality that provides micron-scale resolution of tissue micro-structure over depth ranges of several millimeters. This imaging technique has had a profound effect on the field of ophthalmology, wherein it has become the standard of care for the diagnosis of many retinal pathologies. Applications of OCT in the anterior eye, as well as for imaging of coronary arteries and the gastro-intestinal tract, have also shown promise, but have not yet achieved widespread clinical use. The usable imaging depth of OCT systems is most often limited by one of three factors: optical attenuation, inherent imaging range, or depth-of-focus. The first of these, optical attenuation, stems from the limitation that OCT only detects singly-scattered light. Thus, beyond a certain penetration depth into turbid media, essentially all of the incident light will have been multiply scattered, and can no longer be used for OCT imaging. For many applications (especially retinal imaging), optical attenuation is the most restrictive of the three imaging depth limitations. However, for some applications, especially anterior segment, cardiovascular (catheter-based) and GI (endoscopic) imaging, the usable imaging depth is often not limited by optical attenuation, but rather by the inherent imaging depth of the OCT systems. This inherent imaging depth, which is specific to only Fourier Domain OCT, arises due to two factors: sensitivity fall-off and the complex conjugate ambiguity. Finally, due to the trade-off between lateral resolution and axial depth-of-focus inherent in diffractive optical systems, additional depth limitations sometimes arises in either high lateral resolution or extended depth OCT imaging systems. The depth-of-focus limitation is most apparent in applications such as adaptive optics (AO-) OCT imaging of the retina, and extended depth imaging of the ocular anterior segment. In this dissertation, techniques for extending the imaging range of OCT systems are developed. These techniques include the use of a high spectral purity swept source laser in a full-field OCT system, as well as the use of a peculiar phenomenon known as coherence revival to resolve the complex conjugate ambiguity in swept source OCT. In addition, a technique for extending the depth of focus of OCT systems by using a polarization-encoded, dual-focus sample arm is demonstrated. Along the way, other related advances are also presented, including the development of techniques to reduce crosstalk and speckle artifacts in full-field OCT, and the use of fast optical switches to increase the imaging speed of certain low-duty cycle swept source OCT systems. Finally, the clinical utility of these techniques is demonstrated by combining them to demonstrate high-speed, high resolution, extended-depth imaging of both the anterior and posterior eye simultaneously and in vivo.

Vortex phase-induced changes of the statistical properties of a partially coherent radially polarized beam.

PubMed

Guo, Lina; Chen, Yahong; Liu, Xianlong; Liu, Lin; Cai, Yangjian

2016-06-27

Partially coherent radially polarized (PCRP) beam was introduced and generated in recent years. In this paper, we investigate the statistical properties of a PCRP beam embedded with a vortex phase (i.e., PCRP vortex beam). We derive the analytical formula for the cross-spectral density matrix of a PCRP vortex beam propagating through a paraxial ABCD optical system and analyze the statistical properties of a PCRP vortex beam focused by a thin lens. It is found that the statistical properties of a PCRP vortex beam on propagation are much different from those of a PCRP beam. The vortex phase induces not only the rotation of the beam spot, but also the changes of the beam shape, the degree of polarization and the state of polarization. We also find that the vortex phase plays a role of resisting the coherence-induced degradation of the intensity distribution and the coherence-induced depolarization. Furthermore, we report experimental generation of a PCRP vortex beam for the first time. Our results will be useful for trapping and rotating particles, free-space optical communications and detection of phase object.

Impact of environment on dynamics of exciton complexes in a WS2 monolayer

NASA Astrophysics Data System (ADS)

Jakubczyk, Tomasz; Nogajewski, Karol; Molas, Maciej R.; Bartos, Miroslav; Langbein, Wolfgang; Potemski, Marek; Kasprzak, Jacek

2018-07-01

Scientific curiosity to uncover original optical properties and functionalities of atomically thin semiconductors, stemming from unusual Coulomb interactions in the two-dimensional geometry and multi-valley band structure, drives the research on monolayers of transition metal dichalcogenides (TMDs). While recent works ascertained the exotic energetic schemes of exciton complexes in TMDs, we here infer their unusual coherent dynamics occurring on subpicosecond time scale. The dynamics is largely affected by the disorder landscape on the submicron scale, thus can be uncovered using four-wave mixing in the frequency domain, which enables microscopic investigations and imaging. Focusing on a WS2 monolayer, we observe that exciton coherence is lost primarily due to interaction with phonons and relaxation processes towards optically dark excitonic states. Notably, when temperature is low and disorder weak, excitons large coherence volume results in enhanced oscillator strength, allowing to reach the regime of radiatively limited dephasing. Additionally, we observe long valley coherence for the negatively charged exciton complex. We therefore elucidate the crucial role of exciton environment in the TMDs on its dynamics and show that revealed mechanisms are ubiquitous within this family.

Coherent perfect rotation

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Dawson, Nathan J.; Andrews, James H.

2012-09-01

Two classes of conservative, linear, optical rotary effects (optical activity and Faraday rotation) are distinguished by their behavior under time reversal. Faraday rotation, but not optical activity, is capable of coherent perfect rotation, by which we mean the complete transfer of counterpropagating coherent light fields into their orthogonal polarization. Unlike coherent perfect absorption, however, this process is explicitly energy conserving and reversible. Our study highlights the necessity of time-reversal-odd processes (not just absorption) and coherence in perfect mode conversion and thus informs the optimization of active multiport optical devices.

Kinoform optics applied to X-ray photon correlation spectroscopy.

PubMed

Sandy, A R; Narayanan, S; Sprung, M; Su, J-D; Evans-Lutterodt, K; Isakovic, A F; Stein, A

2010-05-01

Moderate-demagnification higher-order silicon kinoform focusing lenses have been fabricated to facilitate small-angle X-ray photon correlation spectroscopy (XPCS) experiments. The geometric properties of such lenses, their focusing performance and their applicability for XPCS measurements are described. It is concluded that one-dimensional vertical X-ray focusing via silicon kinoform lenses significantly increases the usable coherent flux from third-generation storage-ring light sources for small-angle XPCS experiments.

Corneal thickness and elevation measurements using swept-source optical coherence tomography and slit scanning topography in normal and keratoconic eyes.

PubMed

Jhanji, Vishal; Yang, Bingzhi; Yu, Marco; Ye, Cong; Leung, Christopher K S

2013-11-01

To compare corneal thickness and corneal elevation using swept source optical coherence tomography and slit scanning topography. Prospective study. 41 normal and 46 keratoconus subjects. All eyes were imaged using swept source optical coherence tomography and slit scanning tomography during the same visit. Mean corneal thickness and best-fit sphere measurements were compared between the instruments. Agreement of measurements between swept source optical coherence tomography and scanning slit topography was analyzed. Intra-rater reproducibility coefficient and intraclass correlation coefficient were evaluated. In normal eyes, central corneal thickness measured by swept source optical coherence tomography was thinner compared with slit scanning topography (p < 0.0001) and ultrasound pachymetry (p = < .0001). Ultrasound pachymetry readings had better 95% limits of agreement with swept source optical coherence tomography than slit scanning topography. In keratoconus eyes, central corneal thickness was thinner on swept source optical coherence tomography than slit scanning topography (p = 0.081) and ultrasound pachymetry (p = 0.001). There were significant differences between thinnest corneal thickness, and, anterior and posterior best-fit sphere measurements between both instruments (p < 0.05 for all). Overall, reproducibility coefficients and intraclass correlation coefficients were significantly better with swept source optical coherence tomography for measurement of central corneal thickness, anterior best-fit sphere and, posterior best-fit sphere (all p < 0.001). Corneal thickness and elevation measurements were significantly different between swept source optical coherence tomography and slit scanning topography. With better reproducibility coefficients and intraclass correlation coefficients, swept source optical coherence tomography may provide a reliable alternative for measurement of corneal parameters. © 2013 The Authors. Clinical and Experimental Ophthalmology © 2013 Royal Australian and New Zealand College of Ophthalmologists.

SPECTRAL DOMAIN VERSUS SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE RETINAL CAPILLARY PLEXUSES IN SICKLE CELL MACULOPATHY.

PubMed

Jung, Jesse J; Chen, Michael H; Frambach, Caroline R; Rofagha, Soraya; Lee, Scott S

2018-01-01

To compare the spectral domain and swept source optical coherence tomography angiography findings in two cases of sickle cell maculopathy. A 53-year-old man and a 24-year-old man both with sickle cell disease (hemoglobin SS) presented with no visual complaints; Humphrey visual field testing demonstrated asymptomatic paracentral scotomas that extended nasally in the involved eyes. Clinical examination and multimodal imaging including spectral domain and swept source optical coherence tomography, and spectral domain optical coherence tomography angiography and swept source optical coherence tomography angiography (Carl Zeiss Meditec Inc, Dublin, CA) were performed. Fundus examination of both patients revealed subtle thinning of the macula. En-face swept source optical coherence tomography confirmed the extent of the thinning correlating with the functional paracentral scotomas on Humphrey visual field. Swept source optical coherence tomography B-scan revealed multiple confluent areas of inner nuclear thinning and significant temporal retinal atrophy. En-face 6 × 6-mm spectral domain optical coherence tomography angiography of the macula demonstrated greater loss of the deep capillary plexus compared with the superficial capillary plexus. Swept source optical coherence tomography angiography 12 × 12-mm imaging captured the same macular findings and loss of both plexuses temporally outside the macula. In these two cases of sickle cell maculopathy, deep capillary plexus ischemia is more extensive within the macula, whereas both the superficial capillary plexus and deep capillary plexus are involved outside the macula likely due to the greater oxygen demands and watershed nature of these areas. Swept source optical coherence tomography angiography clearly demonstrates the angiographic extent of the disease correlating with the Humphrey visual field scotomas and confluent areas of inner nuclear atrophy.

Fiber optic interferometry for industrial process monitoring and control applications

NASA Astrophysics Data System (ADS)

Marcus, Michael A.

2002-02-01

Over the past few years we have been developing applications for a high-resolution (sub-micron accuracy) fiber optic coupled dual Michelson interferometer-based instrument. It is being utilized in a variety of applications including monitoring liquid layer thickness uniformity on coating hoppers, film base thickness uniformity measurement, digital camera focus assessment, optical cell path length assessment and imager and wafer surface profile mapping. The instrument includes both coherent and non-coherent light sources, custom application dependent optical probes and sample interfaces, a Michelson interferometer, custom electronics, a Pentium-based PC with data acquisition cards and LabWindows CVI or LabView based application specific software. This paper describes the development evolution of this instrument platform and applications highlighting robust instrument design, hardware, software, and user interfaces development. The talk concludes with a discussion of a new high-speed instrument configuration, which can be utilized for high speed surface profiling and as an on-line web thickness gauge.

Anterior Segment Optical Coherence Tomography for Tear Meniscus Evaluation and its Correlation with other Tear Variables in Healthy Individuals

PubMed Central

Dhasmana, Renu; Nagpal, Ramesh Chander

2016-01-01

Introduction Dry eye is one of the most common ocular diseases in this cyber era. Despite availability of multiple tests, no single test is accurate for the diagnosis of dry eye. Anterior segment optical coherence tomography is the recent tool which can be added in the armentarium of dry eye tests. Aim To evaluate tear meniscus with anterior segment optical coherence tomography and its correlation with other tear variables in normal healthy individuals. Materials and Methods In this prospective cross-sectional observational study, right eye of 203 consecutive patients were studied. All the patients were divided into three groups Group 1, 2 and 3 according to their age ≤20 years, 21-40 years and >40 years respectively. All patients underwent routine ophthalmologic examinations along with slit-lamp bio-microscopy for tear meniscus height measurement, tear film break up time, Schirmer’s I test (with anaesthesia) and optical coherence tomography imaging of inferior tear meniscus height. After focusing of the instrument with a Cross Line (CL) centered on lower tear meniscus at 6’0 clock of cornea, a 6 mm long scan was obtained. The tear meniscus height (μm) and tear meniscus area (mm2) were measured manually with help of callipers by joining upper corneo-meniscus junction to the lower lid-meniscus junction and tear meniscus height and area within the plotted line respectively and calculated by using the integrated analysis available in the custom software. Results There was significant decrease in the all tear variables with the increase in the age. According to age groups in group 1, the mean Schirmer’s (24.0±4.9)mm, tear film break up time (11.1±1.9) sec, tear meniscus height on slit lamp (600.2±167.3)mm were higher but decreased in group 2 (21.5±5.4,10.8±1.4, 597.5±186.3) and group 3 (19.8 ± 5.1, 10.2 ± 1.6, 485.6 ± 157.7) respectively. Schirmer’s test values and tear film break up time were similar in both sexes (p=0.1 and p= 0.9). Tear meniscus height on slit lamp and Optical coherence based tear meniscus area were similar in both sexes (p=0.5 and p=0.1). However, tear meniscus height on optical coherence tomography was significantly higher in females (p=0.04). Value of Schirmer’s and tear film break up time (r =0.2; p= 0.001) and Schirmer’s and tear meniscus height on slit lamp (r=0.6; p<0.001) had positive correlation. Tear meniscus height and tear meniscus area on optical coherence tomography had positive correlation (r =.9; p<0.001). Conclusion On optical coherence tomography tear meniscus height and area significantly correlated. Despite higher values of Schirmer’s, tear film break up time, Slit lamp based tear meniscus height in younger age group the tear meniscus height and tear meniscus area with optical coherence tomography were lower. PMID:27437253

Experimental study of the focusing properties of a Gaussian Schell-model vortex beam.

PubMed

Wang, Fei; Zhu, Shijun; Cai, Yangjian

2011-08-15

We carry out an experimental and theoretical study of the focusing properties of a Gaussian Schell-model (GSM) vortex beam. It is found that we can shape the beam profile of the focused GSM vortex beam by varying its initial spatial coherence width. Focused dark hollow, flat-topped, and Gaussian beam spots can be obtained in our experiment, which will be useful for trapping particles. The experimental results agree well with the theoretical results. © 2011 Optical Society of America

Ultra high energy resolution focusing monochromator for inelastic X-ray scattering spectrometer

DOE PAGES

Suvorov, Alexey; Cunsolo, Alessandro; Chubar, Oleg; ...

2015-11-25

Further development of a focusing monochromator concept for X-ray energy resolution of 0.1 meV and below is presented. Theoretical analysis of several optical layouts based on this concept was supported by numerical simulations performed in the “Synchrotron Radiation Workshop” software package using the physical-optics approach and careful modeling of partially-coherent synchrotron (undulator) radiation. Along with the energy resolution, the spectral shape of the energy resolution function was investigated. We show that under certain conditions the decay of the resolution function tails can be faster than that of the Gaussian function.

Generation of various partially coherent beams and their propagation properties in turbulent atmosphere: a review

NASA Astrophysics Data System (ADS)

Cai, Yangjian

2011-03-01

Partially coherent beams, such as Gaussian Schell-model beam, partially coherent dark hollow beam, partially coherent flat-topped beam and electromagnetic Gaussian Schell-model beam, have important applications in free space optical communications, optical imaging, optical trapping, inertial confinement fusion and nonlinear optics. In this paper, experimental generations of various partially coherent beams are introduced. Furthermore, with the help of a tensor method, analytical formulae for such beams propagating in turbulent atmosphere are derived, and the propagation properties of such beams in turbulent atmosphere are reviewed.

Coherent Optical Communications: Historical Perspectives and Future Directions

NASA Astrophysics Data System (ADS)

Kikuchi, Kazuro

Coherent optical fiber communications were studied extensively in the 1980s mainly because high sensitivity of coherent receivers could elongate the unrepeated transmission distance; however, their research and development have been interrupted for nearly 20 years behind the rapid progress in high-capacity wavelength-division multiplexed (WDM) systems using erbium-doped fiber amplifiers (EDFAs). In 2005, the demonstration of digital carrier phase estimation in coherent receivers has stimulated a widespread interest in coherent optical communications again. This is due to the fact that the digital coherent receiver enables us to employ a variety of spectrally efficient modulation formats such as M-ary phase-shift keying (PSK) and quadrature amplitude modulation (QAM) without relying upon a rather complicated optical phase-locked loop. In addition, since the phase information is preserved after detection, we can realize electrical post-processing functions such as compensation for chromatic dispersion and polarization-mode dispersion in the digital domain. These advantages of the born-again coherent receiver have enormous potential for innovating existing optical communication systems. In this chapter, after reviewing the 20-year history of coherent optical communication systems, we describe the principle of operation of coherent detection, the concept of the digital coherent receiver, and its performance evaluation. Finally, challenges for the future are summarized.

Noncontact quantitative biomechanical characterization of cardiac muscle using shear wave imaging optical coherence tomography

PubMed Central

Wang, Shang; Lopez, Andrew L.; Morikawa, Yuka; Tao, Ge; Li, Jiasong; Larina, Irina V.; Martin, James F.; Larin, Kirill V.

2014-01-01

We report on a quantitative optical elastographic method based on shear wave imaging optical coherence tomography (SWI-OCT) for biomechanical characterization of cardiac muscle through noncontact elasticity measurement. The SWI-OCT system employs a focused air-puff device for localized loading of the cardiac muscle and utilizes phase-sensitive OCT to monitor the induced tissue deformation. Phase information from the optical interferometry is used to reconstruct 2-D depth-resolved shear wave propagation inside the muscle tissue. Cross-correlation of the displacement profiles at various spatial locations in the propagation direction is applied to measure the group velocity of the shear waves, based on which the Young’s modulus of tissue is quantified. The quantitative feature and measurement accuracy of this method is demonstrated from the experiments on tissue-mimicking phantoms with the verification using uniaxial compression test. The experiments are performed on ex vivo cardiac muscle tissue from mice with normal and genetically altered myocardium. Our results indicate this optical elastographic technique is useful as a noncontact tool to assist the cardiac muscle studies. PMID:25071943

IQ imbalance tolerable parallel-channel DMT transmission for coherent optical OFDMA access network

NASA Astrophysics Data System (ADS)

Jung, Sang-Min; Mun, Kyoung-Hak; Jung, Sun-Young; Han, Sang-Kook

2016-12-01

Phase diversity of coherent optical communication provides spectrally efficient higher-order modulation for optical communications. However, in-phase/quadrature (IQ) imbalance in coherent optical communication degrades transmission performance by introducing unwanted signal distortions. In a coherent optical orthogonal frequency division multiple access (OFDMA) passive optical network (PON), IQ imbalance-induced signal distortions degrade transmission performance by interferences of mirror subcarriers, inter-symbol interference (ISI), and inter-channel interference (ICI). We propose parallel-channel discrete multitone (DMT) transmission to mitigate transceiver IQ imbalance-induced signal distortions in coherent orthogonal frequency division multiplexing (OFDM) transmissions. We experimentally demonstrate the effectiveness of parallel-channel DMT transmission compared with that of OFDM transmission in the presence of IQ imbalance.

Coherent optical modulation for antenna remoting

NASA Technical Reports Server (NTRS)

Fitzmartin, D. J.; Gels, R. G.; Balboni, E. J.

1991-01-01

A coherent fiber optic link employing wideband frequency modulation (FM) of the optical carrier is used to transfer radio frequency (RF) or microwave signals. This system is used to link a remotely located antenna to a conveniently located electronics processing site. The advantages of coherent analog fiber optic systems over non-coherent intensity modulated fiber optic analog transmission systems are described. An optical FM link employing an indirect transmitter to frequency modulate the optical carrier and a microwave delay line discriminator receiver is described. Measured performance data for a video signal centered at 60 MHz is presented showing the use of wideband FM in the link.

Detection of Biochemical Pathogens, Laser Stand-off Spectroscopy, Quantum Coherence, and Many Body Quantum Optics

DTIC Science & Technology

2012-02-24

AND SUBTITLE Detection of Biochemical Pathogens, Laser Stand-off Spectroscopy, Quantum Coherence, and Many Body Quantum Optics 6. AUTHORS Marian O...Maximum 200 words) Results of our earlier research in the realm of quantum optics were extended in order to solve the challenging technical problems of...efficient methods of generating UV light via quantum coherence. 14. SUBJECT TERMS Quantum coherence, quantum optics, lasers 15. NUMBER OF PAGES 15

Methods, systems, and apparatus for storage, transfer and/or control of information via matter wave dynamics

NASA Technical Reports Server (NTRS)

Vestergaard Hau, Lene (Inventor)

2012-01-01

Methods, systems and apparatus for generating atomic traps, and for storing, controlling and transferring information between first and second spatially separated phase-coherent objects, or using a single phase-coherent object. For plural objects, both phase-coherent objects have a macroscopic occupation of a particular quantum state by identical bosons or identical BCS-paired fermions. The information may be optical information, and the phase-coherent object(s) may be Bose-Einstein condensates, superfluids, or superconductors. The information is stored in the first phase-coherent object at a first storage time and recovered from the second phase-coherent object, or the same first phase-coherent object, at a second revival time. In one example, an integrated silicon wafer-based optical buffer includes an electrolytic atom source to provide the phase-coherent object(s), a nanoscale atomic trap for the phase-coherent object(s), and semiconductor-based optical sources to cool the phase-coherent object(s) and provide coupling fields for storage and transfer of optical information.

Method and apparatus for determining pressure-induced frequency-shifts in shock-compressed materials

DOEpatents

Moore, David S.; Schmidt, Stephen C.

1985-01-01

A method and an apparatus for conducting coherent anti-Stokes Raman scattering spectroscopy in shock-compressed materials are disclosed. The apparatus includes a sample vessel having an optically transparent wall and an opposing optically reflective wall. Two coherent laser beams, a pump beam and a broadband Stokes beam, are directed through the window and focused on a portion of the sample. In the preferred embodiment, a projectile is fired from a high-pressure gas gun to impact the outside of the reflective wall, generating a planar shock wave which travels through the sample toward the window. The pump and Stokes beams result in the emission from the shock-compressed sample of a coherent anti-Stokes beam, which is emitted toward the approaching reflective wall of the vessel and reflected back through the window. The anti-Stokes beam is folded into a spectrometer for frequency analysis. The results of such analysis are useful for determining chemical and physical phenomena which occur during the shock-compression of the sample.

Method and apparatus for determining pressure-induced frequency-shifts in shock-compressed materials

DOEpatents

Moore, D.S.; Schmidt, S.C.

1983-12-16

A method and an apparatus for conducting coherent anti-Stokes Raman scattering spectroscopy in shock-compressed materials are disclosed. The apparatus includes a sample vessel having an optically transparent wall and an opposing optically reflective wall. Two coherent laser beams, a pump beam and a broadband Stokes beam, are directed through the window and focused on a portion of the sample. In the preferred embodiment, a projectile is fired from a high-pressure gas gun to impact the outside of the reflective wall, generating a planar shock wave which travels through the sample toward the window. The pump and Stokes beams result in the emission from the shock-compressed sample of a coherent anti-Stokes beam, which is emitted toward the approaching reflective wall of the vessel and reflected back through the window. The anti-Stokes beam is folded into a spectrometer for frequency analysis. The results of such analysis are useful for determining chemical and physical phenomena which occur during the shock-compression of the sample.

Dark-field optical coherence microscopy

NASA Astrophysics Data System (ADS)

Pache, C.; Villiger, M. L.; Lasser, T.

2010-02-01

Many solutions have been proposed to produce phase quantitative images of biological cell samples. Among these, Spectral Domain Phase Microscopy combines the fast imaging speed and high sensitivity of Optical Coherence Microscopy (OCM) in the Fourier domain with the high phase stability of common-path interferometry. We report on a new illumination scheme for OCM that enhances the sensitivity for backscattered light and detects the weak sample signal, otherwise buried by the signal from specular reflection. With the use of a Bessel-like beam, a dark-field configuration was realized. Sensitivity measurements for three different illumination configurations were performed to compare our method to standard OCM and extended focus OCM. Using a well-defined scattering and reflecting object, we demonstrated an attenuation of -40 dB of the DC-component and a relative gain of 30 dB for scattered light, compared to standard OCM. In a second step, we applied this technique, referred to as dark-field Optical Coherence Microscopy (dfOCM), to living cells. Chinese hamster ovarian cells were applied in a drop of medium on a coverslide. The cells of ~15 μm in diameter and even internal cell structures were visualized in the acquired tomograms.

4Pi Microscopy.

PubMed

Schmidt, Roman; Engelhardt, Johann; Lang, Marion

2013-01-01

Optical microscopy has become a key technology in the life sciences today. Its noninvasive nature provides access to the interior of intact and even living cells, where specific molecules can be precisely localized by fluorescent tagging. However, the attainable 3D resolution of an optical microscope has long been hampered by a comparatively poor resolution along the optic axis. By coherent focusing through two objective lenses, 4Pi microscopy improves the axial resolution by three- to fivefold. This primer is intended as a starting point for the design and operation of a 4Pi microscope of type A.

All-fiber probe for optical coherence tomography with an extended depth of focus by a high-efficient fiber-based filter

NASA Astrophysics Data System (ADS)

Qiu, Jianrong; Shen, Yi; Shangguan, Ziwei; Bao, Wen; Yang, Shanshan; Li, Peng; Ding, Zhihua

2018-04-01

Although methods have been proposed to maintain high transverse resolution over an increased depth range, it is not straightforward to scale down the bulk-optic solutions to minimized probes of optical coherence tomography (OCT). In this paper, we propose a high-efficient fiber-based filter in an all-fiber OCT probe to realize an extended depth of focus (DOF) while maintaining a high transverse resolution. Mode interference in the probe is exploited to modulate the complex field with controllable radial distribution. The principle of DOF extension by the fiber-based filter is theoretically analyzed. Numerical simulations are conducted to evaluate the performances of the designed probes. A DOF extension ratio of 2.6 over conventional Gaussian beam is obtainable in one proposed probe under a focused beam diameter of 4 . 6 μm. Coupling efficiencies of internal interfaces of the proposed probe are below -40 dB except the last probe-air interface, which can also be depressed to be -44 dB after minor modification in lengths for the filter. Length tolerance of the proposed probe is determined to be - 28 / + 20 μm, which is readily satisfied in fabrication. With the merits of extended-DOF, high-resolution, high-efficiency and easy-fabrication, the proposed probe is promising in endoscopic applications.

Conditions for space invariance in optical data processors used with coherent or noncoherent light.

PubMed

Arsenault, H R

1972-10-01

The conditions for space invariance in coherent and noncoherent optical processors are considered. All linear optical processors are shown to belong to one of two types. The conditions for space invariance are more stringent for noncoherent processors than for coherent processors, so that a system that is linear in coherent light may be nonlinear in noncoherent light. However, any processor that is linear in noncoherent light is also linear in the coherent limit.

Evaluation of a completely robotized neurosurgical operating microscope.

PubMed

Kantelhardt, Sven R; Finke, Markus; Schweikard, Achim; Giese, Alf

2013-01-01

Operating microscopes are essential for most neurosurgical procedures. Modern robot-assisted controls offer new possibilities, combining the advantages of conventional and automated systems. We evaluated the prototype of a completely robotized operating microscope with an integrated optical coherence tomography module. A standard operating microscope was fitted with motors and control instruments, with the manual control mode and balance preserved. In the robot mode, the microscope was steered by a remote control that could be fixed to a surgical instrument. External encoders and accelerometers tracked microscope movements. The microscope was additionally fitted with an optical coherence tomography-scanning module. The robotized microscope was tested on model systems. It could be freely positioned, without forcing the surgeon to take the hands from the instruments or avert the eyes from the oculars. Positioning error was about 1 mm, and vibration faded in 1 second. Tracking of microscope movements, combined with an autofocus function, allowed determination of the focus position within the 3-dimensional space. This constituted a second loop of navigation independent from conventional infrared reflector-based techniques. In the robot mode, automated optical coherence tomography scanning of large surface areas was feasible. The prototype of a robotized optical coherence tomography-integrated operating microscope combines the advantages of a conventional manually controlled operating microscope with a remote-controlled positioning aid and a self-navigating microscope system that performs automated positioning tasks such as surface scans. This demonstrates that, in the future, operating microscopes may be used to acquire intraoperative spatial data, volume changes, and structural data of brain or brain tumor tissue.

Measurement of the temperature dependence of Young's modulus of cartilage by phase-sensitive optical coherence elastography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, C H; Li, J; Singh, M

2014-08-31

The development of an effective system to monitor the changes in the elastic properties of cartilage tissue with increasing temperature in laser reconstruction is an urgent practical task. In this paper, the use of phase-sensitive optical coherence elastography for detection of elastic waves in the sample has allowed Young's modulus of cartilage tissue to be measured directly during heating. Young's modulus was calculated from the group velocity of propagation of elastic waves excited by means of a system supplying focused air pulses. The measurement results are in agreement with the results of measurements of the modulus of elasticity under mechanicalmore » compression. The technique developed allows for noninvasive measurements; its development is promising for the use in vivo. (laser biophotonics)« less

Evaluating the coherence and time-domain profile of quantum cascade laser frequency combs

DOE PAGES

Burghoff, David; Yang, Yang; Hayton, Darren J.; ...

2015-01-01

Recently, much attention has been focused on the generation of optical frequency combs from quantum cascade lasers. We discuss how fast detectors can be used to demonstrate the mutual coherence of such combs, and present an inequality that can be used to quantitatively evaluate their performance. We discuss several technical issues related to shifted wave interference Fourier Transform spectroscopy (SWIFTS), and show how such measurements can be used to elucidate the time-domain properties of such combs, showing that they can possess signatures of both frequency-modulation and amplitude-modulation.

Noise Effects on Entangled Coherent State Generated via Atom-Field Interaction and Beam Splitter

NASA Astrophysics Data System (ADS)

Najarbashi, G.; Mirzaei, S.

2016-05-01

In this paper, we introduce a controllable method for producing two and three-mode entangled coherent states (ECS's) using atom-field interaction in cavity QED and beam splitter. The generated states play central roles in linear optics, quantum computation and teleportation. We especially focus on qubit, qutrit and qufit like ECS's and investigate their entanglement by concurrence measure. Moreover, we illustrate decoherence properties of ECS's due to noisy channels, using negativity measure. At the end the effect of noise on monogamy inequality is discussed.

Future aspects of cellular and molecular research in clinical voice treatment aspects of optical coherence tomography

NASA Astrophysics Data System (ADS)

Pedersen, Mette; Mahmood, Sanila

2015-02-01

Focus is upon our clinical experience in a prospective cohort study on cure of dystonia where the mode of treatment was fexofenadine tablets and local budesonide inhaler in the larynx, and in a randomized controlled trial of lifestyle change related to acid provocation of food and habits in laryngopharyngeal reflux (LPR). The advanced high-speed films is one new tool, another being optical coherence tomography (OCT), which should be used in the future in randomized controlled trials. We are focusing on OCT of the swallowing process in the oesophagaus and larynx as well as the vocal fold function. It can be shown on OCT how the layer of the vocal folds develop, possibly corresponding to hormonal and paediatric development. The arytenoid area in the larynx should also be focused upon with OCT in pathology. The thyroid function is related to voice and the swallowing function, both hormonally and pathoanatomically. We know too little about voice and thyroid hormones in an updated way as well as the outer anatomic supporting muscular structure of the larynx, related to thyroid immune degeneration and cysts. Also, here OCT analyses might be of value.

Numerical simulations of the hard X-ray pulse intensity distribution at the Linac Coherent Light Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pardini, Tom; Aquila, Andrew; Boutet, Sebastien

Numerical simulations of the current and future pulse intensity distributions at selected locations along the Far Experimental Hall, the hard X-ray section of the Linac Coherent Light Source (LCLS), are provided. Estimates are given for the pulse fluence, energy and size in and out of focus, taking into account effects due to the experimentally measured divergence of the X-ray beam, and measured figure errors of all X-ray optics in the beam path. Out-of-focus results are validated by comparison with experimental data. Previous work is expanded on, providing quantitatively correct predictions of the pulse intensity distribution. Numerical estimates in focus aremore » particularly important given that the latter cannot be measured with direct imaging techniques due to detector damage. Finally, novel numerical estimates of improvements to the pulse intensity distribution expected as part of the on-going upgrade of the LCLS X-ray transport system are provided. As a result, we suggest how the new generation of X-ray optics to be installed would outperform the old one, satisfying the tight requirements imposed by X-ray free-electron laser facilities.« less

Numerical simulations of the hard X-ray pulse intensity distribution at the Linac Coherent Light Source

DOE PAGES

Pardini, Tom; Aquila, Andrew; Boutet, Sebastien; ...

2017-06-15

Numerical simulations of the current and future pulse intensity distributions at selected locations along the Far Experimental Hall, the hard X-ray section of the Linac Coherent Light Source (LCLS), are provided. Estimates are given for the pulse fluence, energy and size in and out of focus, taking into account effects due to the experimentally measured divergence of the X-ray beam, and measured figure errors of all X-ray optics in the beam path. Out-of-focus results are validated by comparison with experimental data. Previous work is expanded on, providing quantitatively correct predictions of the pulse intensity distribution. Numerical estimates in focus aremore » particularly important given that the latter cannot be measured with direct imaging techniques due to detector damage. Finally, novel numerical estimates of improvements to the pulse intensity distribution expected as part of the on-going upgrade of the LCLS X-ray transport system are provided. As a result, we suggest how the new generation of X-ray optics to be installed would outperform the old one, satisfying the tight requirements imposed by X-ray free-electron laser facilities.« less

Laser diode technology for coherent communications

NASA Technical Reports Server (NTRS)

Channin, D. J.; Palfrey, S. L.; Toda, M.

1989-01-01

The effect of diode laser characteristics on the overall performance capabilities of coherent communication systems is discussed. In particular, attention is given to optical performance issues for diode lasers in coherent systems, measurements of key performance parameters, and optical requirements for coherent single-channel and multichannel communication systems. The discussion also covers limitations imposed by diode laser optical performance on multichannel system capabilities and implications for future developments.

Propagation of a partially coherent hollow vortex Gaussian beam through a paraxial ABCD optical system in turbulent atmosphere.

PubMed

Zhou, Guoquan; Cai, Yangjian; Chu, Xiuxiang

2012-04-23

The propagation of a partially coherent hollow vortex Gaussian beam through a paraxial ABCD optical system in turbulent atmosphere has been investigated. The analytical expressions for the average intensity and the degree of the polarization of a partially coherent hollow vortex Gaussian beam through a paraxial ABCD optical system are derived in turbulent atmosphere, respectively. The average intensity distribution and the degree of the polarization of a partially coherent hollow vortex Gaussian beam in turbulent atmosphere are numerically demonstrated. The influences of the beam parameters, the topological charge, the transverse coherent lengths, and the structure constant of the atmospheric turbulence on the propagation of a partially coherent hollow vortex Gaussian beam in turbulent atmosphere are also examined in detail. This research is beneficial to the practical applications in free-space optical communications and the remote sensing of the dark hollow beams. © 2012 Optical Society of America

Defect of focus in two-line resolution with Hanning amplitude filters

NASA Astrophysics Data System (ADS)

Karunasagar, D.; Bhikshamaiah, G.; Keshavulu Goud, M.; Lacha Goud, S.

In the presence of defocusing the modified Sparrow limits of resolution for two-line objects have been investigated for a diffraction-limited coherent optical system apodized by generalized Hanning amplitude filters. These limits have been studied as a function of different parameters such as intensity ratio, the order of the filter for various amounts of apodization parameter. Results reveal that in some situations the defocusing is effective in enhancing the resolution of an optical system.

Using an incoherent target return to adaptively focus through atmospheric turbulence

NASA Astrophysics Data System (ADS)

Nelson, W.; Palastro, J. P.; Wu, C.; Davis, C. C.

2016-03-01

A laser beam propagating to a remote target through atmospheric turbulence acquires intensity fluctuations. If the target is cooperative and provides a coherent return beam, the phase measured near the beam transmitter and adaptive optics can, in principle, correct these fluctuations. Generally, however, the target is uncooperative. In this case, we show that an incoherent return from the target can be used instead. Using the principle of reciprocity, we derive a novel relation between the field at the target and the reflected field at a detector. We simulate an adaptive optics system that utilizes this relation to focus a beam through atmospheric turbulence onto the incoherent surface.

Quantification of numerical aperture-dependence of the OCT attenuation coefficient (Conference Presentation)

NASA Astrophysics Data System (ADS)

Peinado, Liliana M.; Bloemen, Paul R.; Almasian, Mitra; van Leeuwen, Ton G.; Faber, Dirk J.

2016-03-01

Despite the improvements in early cancer diagnosis, adequate diagnostic tools for early staging of bladder cancer tumors are lacking [1]. MEMS-probes based on optical coherence tomography (OCT) provide cross-sectional imaging with a high-spatial resolution at a high-imaging speed, improving visualization of cancerous tissue [2-3]. Additionally, studies show that the measurement of localized attenuation coefficient allows discrimination between healthy and cancerous tissue [4]. We have designed a new miniaturized MEMS-probe based on OCT that will optimize early diagnosis by improving functional visualization of suspicious lesions in bladder. During the optical design phase of the probe, we have studied the effect of the numerical aperture (NA) on the OCT signal attenuation. For this study, we have employed an InnerVision Santec OCT system with several numerical apertures (25mm, 40mm, 60mm, 100mm, 150mm and 200mm using achromatic lenses). The change in attenuation coefficient was studied using 15 dilutions of intralipid ranging between 6*10-5 volume% and 20 volume%. We obtained the attenuation coefficient from the OCT images at several fixed positions of the focuses using established OCT models (e.g. single scattering with known confocal point spread function (PSF) [5] and multiple scattering using the Extended Huygens Fresnel model [6]). As a result, a non-linear increase of the scattering coefficient as a function of intralipid concentration (due to dependent scattering) was obtained for all numerical apertures. For all intralipid samples, the measured attenuation coefficient decreased with a decrease in NA. Our results suggest a non-negligible influence of the NA on the measured attenuation coefficient. [1] Khochikar MV. Rationale for an early detection program for bladder cancer. Indian J Urol 2011 Apr-Jun; 27(2): 218-225. [2] Sun J and Xie H. Review Article MEMS-Based Endoscopic Optical Coherence Tomography. IJO 2011, Article ID 825629, 12 pages. doi:10.1155/2011/825629. [3] Jung W and Boppart S. Optical coherence tomography for rapid tissue screening and directed histological sectioning. Anal Cell Pathol (Amst). 2012; 35(3): 129-143. [4] R. Wessels et al. Optical coherence tomography in vulvar intraepithelial neoplasia. J Biomed Opt 2012 Nov; 17(11): 116022. [5] Faber D, van der Meer F, Aalders M, van Leeuwen T. Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography. OPT EXPRESS 2004; 12 (19): 4353-43. [6] Thrane L, Yura HT, and Andersen PE. Analysis of optical coherence tomography systems based on the extended Huygens-Fresnel principle. JOSA 2000; 17(3): 484-490.

A chip-integrated coherent photonic-phononic memory.

PubMed

Merklein, Moritz; Stiller, Birgit; Vu, Khu; Madden, Stephen J; Eggleton, Benjamin J

2017-09-18

Controlling and manipulating quanta of coherent acoustic vibrations-phonons-in integrated circuits has recently drawn a lot of attention, since phonons can function as unique links between radiofrequency and optical signals, allow access to quantum regimes and offer advanced signal processing capabilities. Recent approaches based on optomechanical resonators have achieved impressive quality factors allowing for storage of optical signals. However, so far these techniques have been limited in bandwidth and are incompatible with multi-wavelength operation. In this work, we experimentally demonstrate a coherent buffer in an integrated planar optical waveguide by transferring the optical information coherently to an acoustic hypersound wave. Optical information is extracted using the reverse process. These hypersound phonons have similar wavelengths as the optical photons but travel at five orders of magnitude lower velocity. We demonstrate the storage of phase and amplitude of optical information with gigahertz bandwidth and show operation at separate wavelengths with negligible cross-talk.Optical storage implementations based on optomechanical resonator are limited to one wavelength. Here, exploiting stimulated Brillouin scattering, the authors demonstrate a coherent optical memory based on a planar integrated waveguide, which can operate at different wavelengths without cross-talk.

HYBRID Simulations of Diffraction-Limited Focusing with Kirkpatrick-Baez Mirrors for a Next-Generation In Situ Hard X-ray Nanoprobe

NASA Astrophysics Data System (ADS)

Maser, Jörg; Shi, Xianbo; Reininger, Ruben; Lai, Barry; Vogt, Stefan

2016-12-01

Next-generation hard X-ray nanoprobe beamlines such as the In Situ Nanoprobe (ISN) beamline being planned at the Advanced Photon Source aim at providing very high spatial resolution while also enabling very high focused flux, to study complex materials and devices using fast, multidimensional imaging across many length scales. The ISN will use diffractive optics to focus X-rays with a bandpass of Δ E/ E = 10-4 into a focal spot of 20 nm or below. Reflective optics in Kirkpatrick-Baez geometry will be used to focus X-rays with a bandpass as large as Δ E/ E = 10-2 into a focal spot of 50 nm. Diffraction-limited focusing with reflective optics is achieved by spatial filtering and use of a very long, vertically focusing mirror. To quantify the performance of the ISN beamline, we have simulated the propagation of both partially and fully coherent wavefronts from the undulator source, through the ISN beamline and into the mirror-based focal spot. Simulations were carried out using the recently developed software " HYBRID."

Structure and symmetry in coherent perfect polarization rotation

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Zhou, Chuanhong; Andrews, James H.; Baker, Michael A.

2015-01-01

Theoretical investigations of different routes to coherent perfect polarization rotation illustrate its phenomenological connection with coherent perfect absorption. Our study of systems with broken parity, layering, combined Faraday rotation and optical activity, or a rotator-loaded optical cavity highlights their similarity and suggests alternate approaches to improving and miniaturizing optical devices.

Optical coherence tomography angiography in age-related macular degeneration: The game changer.

PubMed

Lupidi, Marco; Cerquaglia, Alessio; Chhablani, Jay; Fiore, Tito; Singh, Sumit Randhir; Cardillo Piccolino, Felice; Corbucci, Roberta; Coscas, Florence; Coscas, Gabriel; Cagini, Carlo

2018-04-01

Optical coherence tomography angiography is one of the biggest advances in ophthalmic imaging. It enables a depth-resolved assessment of the retinal and choroidal blood flow, far exceeding the levels of detail commonly obtained with dye angiographies. One of the first applications of optical coherence tomography angiography was in detecting the presence of choroidal neovascularization in age-related macular degeneration and establishing its position in relation to the retinal pigmented epithelium and Bruch's membrane, and thereby classifying the CNV as type 1, type 2, type 3, or mixed lesions. Optical coherence tomography angiograms, due to the longer wavelength used by optical coherence tomography, showed a more distinct choroidal neovascularization vascular pattern than fluorescein angiography, since there is less suffering from light scattering or is less obscured by overlying subretinal hemorrhages or exudation. Qualitative and quantitative assessments of optical coherence tomography angiography findings in exudative and nonexudative age-related macular degeneration have been largely investigated within the past 3 years both in clinical and experimental settings. This review constitutes an up-to-date of all the potential applications of optical coherence tomography angiography in age-related macular degeneration in order to better understand how to translate its theoretical usefulness into the current clinical practice.

Coherence rephasing combined with spin-wave storage using chirped control pulses

NASA Astrophysics Data System (ADS)

Demeter, Gabor

2014-06-01

Photon-echo based optical quantum memory schemes often employ intermediate steps to transform optical coherences to spin coherences for longer storage times. We analyze a scheme that uses three identical chirped control pulses for coherence rephasing in an inhomogeneously broadened ensemble of three-level Λ systems. The pulses induce a cyclic permutation of the atomic populations in the adiabatic regime. Optical coherences created by a signal pulse are stored as spin coherences at an intermediate time interval, and are rephased for echo emission when the ensemble is returned to the initial state. Echo emission during a possible partial rephasing when the medium is inverted can be suppressed with an appropriate choice of control pulse wave vectors. We demonstrate that the scheme works in an optically dense ensemble, despite control pulse distortions during propagation. It integrates conveniently the spin-wave storage step into memory schemes based on a second rephasing of the atomic coherences.

Scrambled coherent superposition for enhanced optical fiber communication in the nonlinear transmission regime.

PubMed

Liu, Xiang; Chandrasekhar, S; Winzer, P J; Chraplyvy, A R; Tkach, R W; Zhu, B; Taunay, T F; Fishteyn, M; DiGiovanni, D J

2012-08-13

Coherent superposition of light waves has long been used in various fields of science, and recent advances in digital coherent detection and space-division multiplexing have enabled the coherent superposition of information-carrying optical signals to achieve better communication fidelity on amplified-spontaneous-noise limited communication links. However, fiber nonlinearity introduces highly correlated distortions on identical signals and diminishes the benefit of coherent superposition in nonlinear transmission regime. Here we experimentally demonstrate that through coordinated scrambling of signal constellations at the transmitter, together with appropriate unscrambling at the receiver, the full benefit of coherent superposition is retained in the nonlinear transmission regime of a space-diversity fiber link based on an innovatively engineered multi-core fiber. This scrambled coherent superposition may provide the flexibility of trading communication capacity for performance in future optical fiber networks, and may open new possibilities in high-performance and secure optical communications.

Coherent phonon optics in a chip with an electrically controlled active device.

PubMed

Poyser, Caroline L; Akimov, Andrey V; Campion, Richard P; Kent, Anthony J

2015-02-05

Phonon optics concerns operations with high-frequency acoustic waves in solid media in a similar way to how traditional optics operates with the light beams (i.e. photons). Phonon optics experiments with coherent terahertz and sub-terahertz phonons promise a revolution in various technical applications related to high-frequency acoustics, imaging, and heat transport. Previously, phonon optics used passive methods for manipulations with propagating phonon beams that did not enable their external control. Here we fabricate a phononic chip, which includes a generator of coherent monochromatic phonons with frequency 378 GHz, a sensitive coherent phonon detector, and an active layer: a doped semiconductor superlattice, with electrical contacts, inserted into the phonon propagation path. In the experiments, we demonstrate the modulation of the coherent phonon flux by an external electrical bias applied to the active layer. Phonon optics using external control broadens the spectrum of prospective applications of phononics on the nanometer scale.

Multi-Aperture Digital Coherent Combining for Free-Space Optical Communication Receivers

DTIC Science & Technology

2016-04-21

Distribution A: Public Release; unlimited distribution 2016 Optical Society of America OCIS codes: (060.1660) Coherent communications; (070.2025) Discrete ...Coherent combining algorithm Multi-aperture coherent combining enables using many discrete apertures together to create a large effective aperture. A

Atmospheric free-space coherent optical communications with adaptive optics

NASA Astrophysics Data System (ADS)

Ting, Chueh; Zhang, Chengyu; Yang, Zikai

2017-02-01

Free-space coherent optical communications have a potential application to offer last mile bottleneck solution in future local area networks (LAN) because of their information carrier, information security and license-free status. Coherent optical communication systems using orthogonal frequency division multiplexing (OFDM) digital modulation are successfully demonstrated in a long-haul tens Giga bits via optical fiber, but they are not yet available in free space due to atmospheric turbulence-induced channel fading. Adaptive optics is recognized as a promising technology to mitigate the effects of atmospheric turbulence in free-space optics. In this paper, a free-space coherent optical communication system using an OFDM digital modulation scheme and adaptive optics (FSO OFDM AO) is proposed, a Gamma-Gamma distribution statistical channel fading model for the FSO OFDM AO system is examined, and FSO OFDM AO system performance is evaluated in terms of bit error rate (BER) versus various propagation distances.

Complex Pupil Masks for Aberrated Imaging of Closely Spaced Objects

NASA Astrophysics Data System (ADS)

Reddy, A. N. K.; Sagar, D. K.; Khonina, S. N.

2017-12-01

Current approach demonstrates the suppression of optical side-lobes and the contraction of the main lobe in the composite image of two object points of the optical system under the influence of defocusing effect when an asymmetric phase edges are imposed over the apodized circular aperture. The resolution of two point sources having different intensity ratio is discussed in terms of the modified Sparrow criterion, functions of the degree of coherence of the illumination, the intensity difference and the degree of asymmetric phase masking. Here we have introduced and explored the effects of focus aberration (defect-of-focus) on the two-point resolution of the optical systems. Results on the aberrated composite image of closely spaced objects with amplitude mask and asymmetric phase masks forms a significant contribution in astronomical and microscopic observations.

Apparatus and method for generating partially coherent illumination for photolithography

DOEpatents

Sweatt, W.C.

1999-07-06

The present invention relates an apparatus and method for creating a bright, uniform source of partially coherent radiation for illuminating a pattern, in order to replicate an image of said pattern with a high degree of acuity. The present invention introduces a novel scatter plate into the optical path of source light used for illuminating a replicated object. The scatter plate has been designed to interrupt a focused, incoming light beam by introducing between about 8 to 24 diffraction zones blazed onto the surface of the scatter plate which intercept the light and redirect it to a like number of different positions in the condenser entrance pupil each of which is determined by the relative orientation and the spatial frequency of the diffraction grating in each of the several zones. Light falling onto the scatter plate, therefore, generates a plurality of unphased sources of illumination as seen by the back half of the optical system. The system includes a high brightness source, such as a laser, creating light which is taken up by a beam forming optic which focuses the incoming light into a condenser which in turn, focuses light into a field lens creating Kohler illumination image of the source in a camera entrance pupil. The light passing through the field lens illuminates a mask which interrupts the source light as either a positive or negative image of the object to be replicated. Light passing by the mask is focused into the entrance pupil of the lithographic camera creating an image of the mask onto a receptive media. 7 figs.

Apparatus and method for generating partially coherent illumination for photolithography

DOEpatents

Sweatt, William C.

1999-01-01

The present invention relates an apparatus and method for creating a bright, uniform source of partially coherent radiation for illuminating a pattern, in order to replicate an image of said pattern with a high degree of acuity. The present invention introduces a novel scatter plate into the optical path of source light used for illuminating a replicated object. The scatter plate has been designed to interrupt a focused, incoming light beam by introducing between about 8 to 24 diffraction zones blazed onto the surface of the scatter plate which intercept the light and redirect it to a like number of different positions in the condenser entrance pupil each of which is determined by the relative orientation and the spatial frequency of the diffraction grating in each of the several zones. Light falling onto the scatter plate, therefore, generates a plurality of unphased sources of illumination as seen by the back half of the optical system. The system includes a high brightness source, such as a laser, creating light which is taken up by a beam forming optic which focuses the incoming light into a condenser which in turn, focuses light into a field lens creating Kohler illumination image of the source in a camera entrance pupil. The light passing through the field lens illuminates a mask which interrupts the source light as either a positive or negative image of the object to be replicated. Light passing by the mask is focused into the entrance pupil of the lithographic camera creating an image of the mask onto a receptive media.

Tracing the phase of focused broadband laser pulses

NASA Astrophysics Data System (ADS)

Hoff, Dominik; Krüger, Michael; Maisenbacher, Lothar; Sayler, A. M.; Paulus, Gerhard G.; Hommelhoff, Peter

2017-10-01

Precise knowledge of the behaviour of the phase of light in a focused beam is fundamental to understanding and controlling laser-driven processes. More than a hundred years ago, an axial phase anomaly for focused monochromatic light beams was discovered and is now commonly known as the Gouy phase. Recent theoretical work has brought into question the validity of applying this monochromatic phase formulation to the broadband pulses becoming ubiquitous today. Based on electron backscattering at sharp nanometre-scale metal tips, a method is available to measure light fields with sub-wavelength spatial resolution and sub-optical-cycle time resolution. Here we report such a direct, three-dimensional measurement of the spatial dependence of the optical phase of a focused, 4-fs, near-infrared pulsed laser beam. The observed optical phase deviates substantially from the monochromatic Gouy phase--exhibiting a much more complex spatial dependence, both along the propagation axis and in the radial direction. In our measurements, these significant deviations are the rule and not the exception for focused, broadband laser pulses. Therefore, we expect wide ramifications for all broadband laser-matter interactions, such as in high-harmonic and attosecond pulse generation, femtochemistry, ophthalmological optical coherence tomography and light-wave electronics.

Optical Coherence Tomography for Brain Imaging and Developmental Biology

PubMed Central

Men, Jing; Huang, Yongyang; Solanki, Jitendra; Zeng, Xianxu; Alex, Aneesh; Jerwick, Jason; Zhang, Zhan; Tanzi, Rudolph E.; Li, Airong; Zhou, Chao

2016-01-01

Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brain in vitro and in vivo in animal models. Due to its non-invasiveness nature, OCT enables longitudinal imaging of developing specimens in vivo without potential damage from surgical operation, tissue fixation and processing, and staining with exogenous contrast agents. In this paper, various OCT applications in brain imaging and developmental biology are reviewed, with a particular focus on imaging heart development. In addition, we report findings on the effects of a circadian gene (Clock) and high-fat-diet on heart development in Drosophila melanogaster. These findings contribute to our understanding of the fundamental mechanisms connecting circadian genes and obesity to heart development and cardiac diseases. PMID:27721647

High resolution multiple excitation spot optical microscopy

NASA Astrophysics Data System (ADS)

Dilipkumar, Shilpa; Mondal, Partha Pratim

2011-06-01

We propose fundamental improvements in three-dimensional (3D) resolution of multiple excitation spot optical microscopy. The excitation point spread function (PSF) is generated by two interfering counter-propagating depth-of-focus beams along the optical axis. Detection PSF is obtained by coherently interfering the emitted fluorescent light (collected by both the objectives) at the detector. System PSF shows upto 14-fold reduction in focal volume as compared to confocal, and almost 2-fold improvement in lateral resolution. Proposed PSF has the ability to simultaneously excite multiple 3D-spots of sub-femtoliter volume. Potential applications are in fluorescence microscopy and nanobioimaging.

Optimized mirror shape tuning using beam weightings based on distance, angle of incidence, reflectivity, and power.

PubMed

Goldberg, Kenneth A; Yashchuk, Valeriy V

2016-05-01

For glancing-incidence optical systems, such as short-wavelength optics used for nano-focusing, incorporating physical factors in the calculations used for shape optimization can improve performance. Wavefront metrology, including the measurement of a mirror's shape or slope, is routinely used as input for mirror figure optimization on mirrors that can be bent, actuated, positioned, or aligned. Modeling shows that when the incident power distribution, distance from focus, angle of incidence, and the spatially varying reflectivity are included in the optimization, higher Strehl ratios can be achieved. Following the works of Maréchal and Mahajan, optimization of the Strehl ratio (for peak intensity with a coherently illuminated system) occurs when the expectation value of the phase error's variance is minimized. We describe an optimization procedure based on regression analysis that incorporates these physical parameters. This approach is suitable for coherently illuminated systems of nearly diffraction-limited quality. Mathematically, this work is an enhancement of the methods commonly applied for ex situ alignment based on uniform weighting of all points on the surface (or a sub-region of the surface). It follows a similar approach to the optimization of apodized and non-uniformly illuminated optical systems. Significantly, it reaches a different conclusion than a more recent approach based on minimization of focal plane ray errors.

EN FACE IMAGING OF RETINAL ARTERY MACROANEURYSMS USING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY.

PubMed

Hanhart, Joel; Strassman, Israel; Rozenman, Yaakov

2017-01-01

To describe the advantages of en face view with swept-source optical coherence tomography in assessing the morphologic features of retinal arterial macroaneurysms, their consequences on adjacent retina, planning laser treatment, and evaluating its effects. Three eyes were treated for retinal arterial macroaneurysms and followed by swept-source optical coherence tomography in 2014-2015. En face images of the retina and choroid were obtained by EnView, a swept-source optical coherence tomography program. Retinal arterial macroaneurysms have a typical optical coherence tomography appearance. En face view allows delineation of the macroaneurysm wall, thrombotic components within the dilation, and lumen measurement. Hemorrhage, lipids, and fluids can be precisely described in terms of amount and extent over the macula and depth. This technique is also practical for planning focal laser treatment and determining its effects. En face swept-source optical coherence tomography is a rapid, noninvasive, high-resolution, promising technology, which allows excellent visualization of retinal arterial macroaneurysms and their consequences on surrounding tissues. It could make angiography with intravenous injection redundant in planning and assessing therapy.

Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

PubMed Central

Tsai, Meng-Tsan; Chang, Feng-Yu; Lee, Cheng-Kuang; Gong, Cihun-Siyong Alex; Lin, Yu-Xiang; Lee, Jiann-Der; Yang, Chih-Hsun; Liu, Hao-Li

2014-01-01

Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment. With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied. Moreover, the vascular effects induced by FUS treatment with and without the presence of microbubbles were investigated and quantitatively compared. Additionally, 2D and 3D speckle-variance images were used for quantitative observation of blood leakage from vessels due to the permeability enhancement caused by FUS, which could be an indicator that can be used to determine the influence of FUS power exposure. In conclusion, SVOCT can be a useful tool for monitoring FUS treatment in real time, facilitating the dynamic observation of temporal effects and helping to determine the optimal FUS power. PMID:25071945

Spectral domain optical coherence tomography findings in tamoxifen retinopathy--a case report.

PubMed

Nair, Sandhya Narayanan; Anantharaman, Giridhar; Gopalakrishnan, Mahesh; Vyas, Jyothiprakash

2013-01-01

To report spectral domain optical coherence tomography findings in a case of typical tamoxifen retinopathy. In this observational case report, a patient with tamoxifen retinopathy was imaged with spectral domain optical coherence tomography and fundus auto fluorescence. Spectral domain optical coherence tomography showed numerous hyperreflective spots within the retina, mainly in the inner retinal layers in both the eyes. The external limiting membrane, the Inner Segment-Outer Segment junction, and the photoreceptors were not discernable at the fovea in the right eye. In the left eye, there was foveal atrophy with total loss of photoreceptors. The autofluorescent images showed macular hypofluorescence with foveal hyperfluorescence. Spectral domain optical coherence tomography demonstrated abnormalities in the outer retinal layers in tamoxifen retinopathy. There were also characteristic alterations in the autofluorescence pattern at the macula in tamoxifen retinopathy.

Characterization of dynamic physiology of the bladder by optical coherence tomography

NASA Astrophysics Data System (ADS)

Yuan, Zhijia; Keng, Kerri; Pan, Rubin; Ren, Hugang; Du, Congwu; Kim, Jason; Pan, Yingtian

2012-03-01

Because of its high spatial resolution and noninvasive imaging capabilities, optical coherence tomography has been used to characterize the morphological details of various biological tissues including urinary bladder and to diagnose their alternations (e.g., cancers). In addition to static morphology, the dynamic features of tissue morphology can provide important information that can be used to diagnose the physiological and functional characteristics of biological tissues. Here, we present the imaging studies based on optical coherence tomography to characterize motion related physiology and functions of rat bladder detrusor muscles and compared the results with traditional biomechanical measurements. Our results suggest that optical coherence tomography is capable of providing quantitative evaluation of contractile functions of intact bladder (without removing bladder epithelium and connective tissue), which is potentially of more clinical relevance for future clinical diagnosis - if incorporated with cystoscopic optical coherence tomography.

Coherent Excitation of Optical Phonons in GaAs by Broadband Terahertz Pulses

PubMed Central

Fu, Zhengping; Yamaguchi, Masashi

2016-01-01

Coherent excitation and control of lattice motion by electromagnetic radiation in optical frequency range has been reported through variety of indirect interaction mechanisms with phonon modes. However, coherent phonon excitation by direct interaction of electromagnetic radiation and nuclei has not been demonstrated experimentally in terahertz (THz) frequency range mainly due to the lack of THz emitters with broad bandwidth suitable for the purpose. We report the experimental observation of coherent phonon excitation and detection in GaAs using ultrafast THz-pump/optical-probe scheme. From the results of THz pump field dependence, pump/probe polarization dependence, and crystal orientation dependence, we attributed THz wave absorption and linear electro-optic effect to the excitation and detection mechanisms of coherent polar TO phonons. Furthermore, the carrier density dependence of the interaction of coherent phonons and free carriers is reported. PMID:27905563

Coupling Photonics and Coherent Spintronics for Low-Loss Flexible Optical Logic

DTIC Science & Technology

2015-12-02

AFRL-AFOSR-VA-TR-2016-0055 Coupling photonics and coherent spintronics for low-loss flexible optical logic Jesse Berezovsky CASE WESTERN RESERVE UNIV...2012 - 14/06/2015 4. TITLE AND SUBTITLE Coupling photonics and coherent spintronics for low-loss flexible optical logic 5a. CONTRACT NUMBER 5b...into devices, ranging from macroscopic optical cavities, to arrays of microlens cavities, to quantum dot-impregnated integrated polymer waveguides

Space optics; Proceedings of the Seminar, Huntsville, Ala., May 22-24, 1979

NASA Technical Reports Server (NTRS)

Wyman, C. L.

1979-01-01

The seminar focused on infrared systems, the space telescope, new design for space astronomy, future earth resources systems, and planetary systems. Papers were presented on infrared astronomy satellite, infrared telescope on Spacelab 2, design alternatives for the Shuttle Infrared Telescope Facility, Spacelab 2 infrared telescope cryogenic system, geometrical theory of diffraction and telescope stray-light analysis, Space Telescope scientific instruments, faint-object spectrograph for the Space Telescope, light scattering from multilayer optics, bidirectional reflectance distribution function measurements of stray light suppression coatings for the Space Telescope, optical fabrication of a 60-in. mirror, interferogram analysis for space optics, nuclear-pumped lasers for space application, geophysical fluid flow experiment, coherent rays for optical astronomy in space, optical system with fiber-optical elements, and Pioneer-Venus solar flux radiometer.

Quantitative shear-wave optical coherence elastography with a programmable phased array ultrasound as the wave source.

PubMed

Song, Shaozhen; Le, Nhan Minh; Huang, Zhihong; Shen, Tueng; Wang, Ruikang K

2015-11-01

The purpose of this study is to implement a beam-steering ultrasound as the wave source for shear-wave optical coherence elastography (SW-OCE) to achieve an extended range of elastic imaging of the tissue sample. We introduce a linear phased array ultrasound transducer (LPAUT) as the remote and programmable wave source and a phase-sensitive optical coherence tomography (OCT) as the sensitive shear-wave detector. The LPAUT is programmed to launch acoustic radiation force impulses (ARFI) focused at desired locations within the range of OCT imaging, upon which the elasticity map of the entire OCT B-scan cross section is recovered by spatial compounding of the elastic maps derived from each launch of AFRIs. We also propose a directional filter to separate the shear-wave propagation at different directions in order to reduce the effect of tissue heterogeneity on the shear-wave propagation within tissue. The feasibility of this proposed approach is then demonstrated by determining the stiffness of tissue-mimicking phantoms with agarose concentrations of 0.5% and 1% and also by imaging the Young's modulus of retinal and choroidal tissues within a porcine eye ball ex vivo. The approach opens up opportunities to combine medical ultrasound imaging and SW-OCE for high-resolution localized quantitative assessment of tissue biomechanical property.

Corneal elastic anisotropy and hysteresis as a function of IOP assessed by optical coherence elastography

NASA Astrophysics Data System (ADS)

Li, Jiasong; Singh, Manmohan; Han, Zhaolong; Wu, Chen; Raghunathan, Raksha; Liu, Chih-Hao; Nair, Achuth; Noorani, Shezaan; Aglyamov, Salavat R.; Twa, Michael D.; Larin, Kirill V.

2016-03-01

The mechanical anisotropic properties of the cornea can be an important indicator for determining the onset and severity of different diseases and can be used to assess the efficacy of various therapeutic interventions, such as cross-linking and LASIK surgery. In this work, we introduce a noncontact method of assessing corneal mechanical anisotropy as a function of intraocular pressure (IOP) using optical coherence elastography (OCE). A focused air-pulse induced low amplitude (<10 μm) elastic waves in fresh porcine corneas in the whole eye-globe configuration in situ. A phase-stabilized swept source optical coherence elastography (PhS-SSOCE) system imaged the elastic wave propagation at stepped radial angles, and the OCE measurements were repeated as the IOP was cycled. The elastic wave velocity was then quantified to determine the mechanical anisotropy and hysteresis of the cornea. The results show that the elastic anisotropy at the corneal of the apex of the cornea becomes more pronounced at higher IOPs, and that there are distinct radial angles of higher and lower stiffness. Due to the noncontact nature and small amplitude of the elastic wave, this method may be useful for characterizing the elastic anisotropy of ocular and other tissues in vivo completely noninvasively.

3D wide field-of-view Gabor-domain optical coherence microscopy advancing real-time in-vivo imaging and metrology

NASA Astrophysics Data System (ADS)

Canavesi, Cristina; Cogliati, Andrea; Hayes, Adam; Tankam, Patrice; Santhanam, Anand; Rolland, Jannick P.

2017-02-01

Real-time volumetric high-definition wide-field-of-view in-vivo cellular imaging requires micron-scale resolution in 3D. Compactness of the handheld device and distortion-free images with cellular resolution are also critically required for onsite use in clinical applications. By integrating a custom liquid lens-based microscope and a dual-axis MEMS scanner in a compact handheld probe, Gabor-domain optical coherence microscopy (GD-OCM) breaks the lateral resolution limit of optical coherence tomography through depth, overcoming the tradeoff between numerical aperture and depth of focus, enabling advances in biotechnology. Furthermore, distortion-free imaging with no post-processing is achieved with a compact, lightweight handheld MEMS scanner that obtained a 12-fold reduction in volume and 17-fold reduction in weight over a previous dual-mirror galvanometer-based scanner. Approaching the holy grail of medical imaging - noninvasive real-time imaging with histologic resolution - GD-OCM demonstrates invariant resolution of 2 μm throughout a volume of 1 x 1 x 0.6 mm3, acquired and visualized in less than 2 minutes with parallel processing on graphics processing units. Results on the metrology of manufactured materials and imaging of human tissue with GD-OCM are presented.

Clinical application of optical coherence tomography in combination with functional diagnostics: advantages and limitations for diagnosis and assessment of therapy outcome in central serous chorioretinopathy.

PubMed

Schliesser, Joshua A; Gallimore, Gary; Kunjukunju, Nancy; Sabates, Nelson R; Koulen, Peter; Sabates, Felix N

2014-01-01

While identifying functional and structural parameters of the retina in central serous chorioretinopathy (CSCR) patients, this study investigated how an optical coherence tomography (OCT)-based diagnosis can be significantly supplemented with functional diagnostic tools and to what degree the determination of disease severity and therapy outcome can benefit from diagnostics complementary to OCT. CSCR patients were evaluated prospectively with microperimetry (MP) and spectral domain optical coherence tomography (SD-OCT) to determine retinal sensitivity function and retinal thickness as outcome measures along with measures of visual acuity (VA). Patients received clinical care that involved focal laser photocoagulation or pharmacotherapy targeting inflammation and neovascularization. Correlation of clinical parameters with a focus on functional parameters, VA, and mean retinal sensitivity, as well as on the structural parameter mean retinal thickness, showed that functional measures were similar in diagnostic power. A moderate correlation was found between OCT data and the standard functional assessment of VA; however, a strong correlation between OCT and MP data showed that diagnostic measures cannot always be used interchangeably, but that complementary use is of higher clinical value. The study indicates that integrating SD-OCT with MP provides a more complete diagnosis with high clinical relevance for complex, difficult to quantify diseases such as CSCR.

Performance verification of adaptive optics for satellite-to-ground coherent optical communications at large zenith angle.

PubMed

Chen, Mo; Liu, Chao; Rui, Daoman; Xian, Hao

2018-02-19

Although there is an urgent demand, it is still a tremendous challenge to use the coherent optical communication technology to the satellite-to-ground data transmission system especially at large zenith angle due to the influence of atmospheric turbulence. Adaptive optics (AO) is a considerable scheme to solve the problem. In this paper, we integrate the adaptive optics (AO) to the coherent laser communications and the performances of mixing efficiency as well as bit-error-rate (BER) at different zenith angles are studied. The analytical results show that the increasing of zenith angle can severely decrease the performances of the coherent detection, and increase the BER to higher than 10 -3 , which is unacceptable. The simulative results of coherent detection with AO compensation indicate that the larger mixing efficiency and lower BER can be performed by the coherent receiver with a high-mode AO compensation. The experiment of correcting the atmospheric turbulence wavefront distortion using a 249-element AO system at large zenith angles is carried out. The result demonstrates that the AO system has a significant improvement on satellite-to-ground coherent optical communication system at large zenith angle. It also indicates that the 249-element AO system can only meet the needs of coherent communication systems at zenith angle smaller than 65̊ for the 1.8m telescope under weak and moderate turbulence.

High-speed asynchronous optical sampling for high-sensitivity detection of coherent phonons

NASA Astrophysics Data System (ADS)

Dekorsy, T.; Taubert, R.; Hudert, F.; Schrenk, G.; Bartels, A.; Cerna, R.; Kotaidis, V.; Plech, A.; Köhler, K.; Schmitz, J.; Wagner, J.

2007-12-01

A new optical pump-probe technique is implemented for the investigation of coherent acoustic phonon dynamics in the GHz to THz frequency range which is based on two asynchronously linked femtosecond lasers. Asynchronous optical sampling (ASOPS) provides the performance of on all-optical oscilloscope and allows us to record optically induced lattice dynamics over nanosecond times with femtosecond resolution at scan rates of 10 kHz without any moving part in the set-up. Within 1 minute of data acquisition time signal-to-noise ratios better than 107 are achieved. We present examples of the high-sensitivity detection of coherent phonons in superlattices and of the coherent acoustic vibration of metallic nanoparticles.

Real-time optical multiple object recognition and tracking system and method

NASA Technical Reports Server (NTRS)

Chao, Tien-Hsin (Inventor); Liu, Hua-Kuang (Inventor)

1990-01-01

System for optically recognizing and tracking a plurality of objects within a field of vision. Laser (46) produces a coherent beam (48). Beam splitter (24) splits the beam into object (26) and reference (28) beams. Beam expanders (50) and collimators (52) transform the beams (26, 28) into coherent collimated light beams (26', 28'). A two-dimensional SLM (54), disposed in the object beam (26'), modulates the object beam with optical information as a function of signals from a first camera (16) which develops X and Y signals reflecting the contents of its field of vision. A hololens (38), positioned in the object beam (26') subsequent to the modulator (54), focuses the object beam at a plurality of focal points (42). A planar transparency-forming film (32), disposed with the focal points on an exposable surface, forms a multiple position interference filter (62) upon exposure of the surface and development processing of the film (32). A reflector (53) directing the reference beam (28') onto the film (32), exposes the surface, with images focused by the hololens (38), to form interference patterns on the surface. There is apparatus (16', 64) for sensing and indicating light passage through respective ones of the positions of the filter (62), whereby recognition of objects corresponding to respective ones of the positions of the filter (62) is affected. For tracking, apparatus (64) focuses light passing through the filter (62) onto a matrix of CCD's in a second camera (16') to form a two-dimensional display of the recognized objects.

Coherent curvature radiation and fast radio bursts

NASA Astrophysics Data System (ADS)

Ghisellini, Gabriele; Locatelli, Nicola

2018-06-01

Fast radio bursts are extragalactic radio transient events lasting a few milliseconds with a Jy flux at 1 GHz. We propose that these properties suggest a neutron star progenitor, and focus on coherent curvature radiation as the radiation mechanism. We study for which sets of parameters the emission can fulfil the observational constraints. Even if the emission is coherent, we find that self-absorption can limit the produced luminosities at low radio frequencies and that an efficient re-acceleration process is needed to balance the dramatic energy losses of the emitting particles. Self-absorption limits the luminosities at low radio frequency, while coherence favours steep optically thin spectra. Furthermore, the magnetic geometry must have a high degree of order to obtain coherent curvature emission. Particles emit photons along their velocity vectors, thereby greatly reducing the inverse Compton mechanism. In this case we predict that fast radio bursts emit most of their luminosities in the radio band and have no strong counterpart in any other frequency bands.

Bendable Focusing X-Ray Optics for the ALS and the LCLS/FEL: Design, Metrology, and Performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yashchuk, V. V.; Yuan, S.; Baker, S.

2010-06-02

We review the recent development of bendable x-ray optics used for focusing of beams of soft and hard x-rays at the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory and at the Linac Coherent Light Source (LCLS) x-ray free electron laser (FEL) at the Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory. For simultaneous focusing in the tangential and sagittal directions, two elliptically cylindrical reflecting elements, a Kirkpatrick-Baez (KB) pair, are used. Because fabrication of elliptical surfaces is complicated, the cost of directly fabricated tangential elliptical cylinders is often prohibitive. Moreover, such optics cannot be easily readjusted for usemore » in multiple, different experimental arrangements, e.g. at different focal distances. This is in contrast to flat optics that are simpler to manufacture and easier to measure by conventional interferometry. The tangential figure of a flat substrate is changed by placing torques (couples) at each end. Depending on the applied couples, one can tune the shape close to a desired tangential cylinder, ellipse or parabola. We review the nature of the bending, requirements and approaches to the mechanical design, describe original optical and at-wavelength techniques for optimal tuning of bendable optics and alignment on the beamline, and provide beamline performance of the bendable optics used for sub-micro and nano focusing of soft x-rays.« less

Optical coherence tomography measurement of the retinal nerve fiber layer in normal and juvenile glaucomatous eyes.

PubMed

Mrugacz, Malgorzata; Bakunowicz-Lazarczyk, Alina

2005-01-01

The aim of this study was to quantitatively assess and compare the thickness of the retinal nerve fiber layer (RNFL) in normal and glaucomatous eyes of children using the optical coherence tomograph. The mean RNFL thickness of normal eyes (n=26) was compared with that of glaucomatous eyes (n=26). The eyes were classified into diagnostic groups based on conventional ophthalmological physical examination, Humphrey 30-2 visual fields, stereoscopic optic nerve head photography, and optical coherence tomography. The mean RNFL was significantly thinner in glaucomatous eyes than in normal eyes: 95+/-26.3 and 132+/-24.5 microm, respectively. More specifically, the RNFL was significantly thinner in glaucomatous eyes than in normal eyes in the inferior quadrant: 87+/-23.5 and 122+/-24.2 microm, respectively. The mean and inferior quadrant RFNL thicknesses as measured by the optical coherence tomograph showed a statistically significant correlation with glaucoma. Optical coherence tomography may contribute to tracking of juvenile glaucoma progression. Copyright (c) 2005 S. Karger AG, Basel.

Fundus autofluorescence and optical coherence tomography findings in thiamine responsive megaloblastic anemia.

PubMed

Ach, Thomas; Kardorff, Rüdiger; Rohrschneider, Klaus

2015-01-01

To report ophthalmologic fundus autofluorescence and spectral domain optical coherence tomography findings in a patient with thiamine responsive megaloblastic anemia (TRMA). A 13-year-old girl with genetically proven TRMA was ophthalmologically (visual acuity, funduscopy, perimetry, electroretinogram) followed up over >5 years. Fundus imaging also included autofluorescence and spectral domain optical coherence tomography. During a 5-year follow-up, visual acuity and visual field decreased, despite a special TRMA diet. Funduscopy revealed bull's eye appearance, whereas fundus autofluorescence showed central and peripheral hyperfluorescence and perifoveal hypofluorescence. Spectral domain optical coherence tomography revealed affected inner segment ellipsoid band and irregularities in the retinal pigment epithelium and choroidea. Autofluorescence and spectral domain optical coherence tomography findings in a patient with TRMA show retinitis pigmentosa-like retina, retinal pigment epithelium, and choroid alterations. These findings might progress even under special TRMA diet, indispensable to life. Ophthalmologist should consider TRMA in patients with deafness and ophthalmologic disorders.

Observation of correlation between route to formation, coherence, noise, and communication performance of Kerr combs

NASA Astrophysics Data System (ADS)

Wang, Pei-Hsun; Ferdous, Fahmida; Miao, Houxun; Wang, Jian; Leaird, Daniel E.; Srinivasan, Kartik; Chen, Lei; Aksyuk, Vladimir; Weiner, Andrew M.

2012-12-01

Microresonator optical frequency combs based on cascaded four-wave mixing are potentially attractive as a multi-wavelength source for on-chip optical communications. In this paper we compare time domain coherence, radio-frequency (RF) intensity noise, and individual line optical communications performance for combs generated from two different silicon nitride microresonators. The comb generated by one microresonator forms directly with lines spaced by a single free spectral range (FSR) and exhibits high coherence, low noise, and excellent 10 Gbit/s optical communications results. The comb generated by the second microresonator forms initially with multiple FSR line spacing, with additional lines later filling to reach single FSR spacing. This comb exhibits degraded coherence, increased intensity noise, and severely degraded communications performance. This study is to our knowledge the first to simultaneously investigate and observe a correlation between the route to comb formation, the coherence, noise, and optical communications performance of a Kerr comb.

Dental optical coherence domain reflectometry explorer

DOEpatents

Everett, Matthew J.; Colston, Jr., Billy W.; Sathyam, Ujwal S.; Da Silva, Luiz B.

2001-01-01

A hand-held, fiber optic based dental device with optical coherence domain reflectometry (OCDR) sensing capabilities provides a profile of optical scattering as a function of depth in the tissue at the point where the tip of the dental explorer touches the tissue. This system provides information on the internal structure of the dental tissue, which is then used to detect caries and periodontal disease. A series of profiles of optical scattering or tissue microstructure are generated by moving the explorer across the tooth or other tissue. The profiles are combined to form a cross-sectional, or optical coherence tomography (OCT), image.

Measurement technique for in situ characterizing aberrations of projection optics in lithographic tools.

PubMed

Wang, Fan; Wang, Xiangzhao; Ma, Mingying

2006-08-20

As the feature size decreases, degradation of image quality caused by wavefront aberrations of projection optics in lithographic tools has become a serious problem in the low-k1 process. We propose a novel measurement technique for in situ characterizing aberrations of projection optics in lithographic tools. Considering the impact of the partial coherence illumination, we introduce a novel algorithm that accurately describes the pattern displacement and focus shift induced by aberrations. Employing the algorithm, the measurement condition is extended from three-beam interference to two-, three-, and hybrid-beam interferences. The experiments are performed to measure the aberrations of projection optics in an ArF scanner.

PREFACE: XVIII International Youth Scientific School "Coherent Optics and Optical Spectroscopy"

NASA Astrophysics Data System (ADS)

Salakhov, M. Kh; Samartsev, V. V.; Gainutdinov, R. Kh

2015-05-01

Kazan Federal University has held the annual International Youth School "Coherent Optics and Optical Spectroscopy" since 1997. The choice of the topic is not accidental. Kazan is the home of photon echo which was predicted at Kazan Physical-Technical Institute in 1963 by Prof. U.G. Kopvil'em and V.R. Nagibarov and observed in Columbia University by N.A. Kurnit, I.D. Abella, and S.R. Hartmann in 1964. Since then, photon echo has become a powerful tool of coherent optical spectroscopy and optical information processing, which have been developed here in Kazan in close collaboration between Kazan Physical-Technical Institute and Kazan Federal University. The main subjects of the XVIII International Youth School are: Nonlinear and coherent optics; Atomic and molecular spectroscopy; Coherent laser spectroscopy; Problems of quantum optics; Quantum theory of radiation; and Nanophotonics and Scanning Probe Microscopy. The unchallenged organizers of that school are Kazan Federal University and Kazan E.K. Zavoisky Physical-Technical Institute. The rector of the School is Professor Myakzyum Salakhov, and the vice-rector is Professor Vitaly Samartsev. The International Youth Scientific School "Coherent Optics and Optical Spectroscopy" follows the global pattern of comprehensive studies of matter properties and their interaction with electromagnetic fields. Since 1997 more than 100 famous scientists from the USA, Germany, Ukraine, Belarus and Russia have given plenary lecture presentations. Here over 1000 young scientists had an opportunity to participate in lively discussions about the latest scientific news. Many young people have submitted interesting reports on photonics, quantum electronics, laser physics, quantum optics, traditional optical and laser spectroscopy, non-linear optics, material science and nanotechnology. Here we are publishing the fullsize papers prepared from the most interesting lectures and reports selected by the Program Committee of the School. The International Youth Scientific School "Coherent Optics and Optical Spectroscopy" was greatly supported by The Optical Society of America, the Russian Foundation for Basic Research, the non-profit Dynasty Foundation, the Tatarstan Academy of Science, and the Ministry of Education and Science of the Russian Federation. It is a pleasure to thank the sponsors and all the participants and contributors who made the International School meeting possible and interesting.

IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP.

PubMed

Labriola, Leanne T; Legarreta, Andrew D; Legarreta, John E; Nadler, Zach; Gallagher, Denise; Hammer, Daniel X; Ferguson, R Daniel; Iftimia, Nicusor; Wollstein, Gadi; Schuman, Joel S

2016-01-01

To elucidate the location of pathological changes in multiple evanescent white dot syndrome (MEWDS) with the use of multimodal adaptive optics (AO) imaging. A 5-year observational case study of a 24-year-old female with recurrent MEWDS. Full examination included history, Snellen chart visual acuity, pupil assessment, intraocular pressures, slit lamp evaluation, dilated fundoscopic exam, imaging with Fourier-domain optical coherence tomography (FD-OCT), blue-light fundus autofluorescence (FAF), fundus photography, fluorescein angiography, and adaptive-optics optical coherence tomography. Three distinct acute episodes of MEWDS occurred during the period of follow-up. Fourier-domain optical coherence tomography and adaptive-optics imaging showed disturbance in the photoreceptor outer segments (PR OS) in the posterior pole with each flare. The degree of disturbance at the photoreceptor level corresponded to size and extent of the visual field changes. All findings were transient with delineation of the photoreceptor recovery from the outer edges of the lesion inward. Hyperautofluorescence was seen during acute flares. Increase in choroidal thickness did occur with each active flare but resolved. Although changes in the choroid and RPE can be observed in MEWDS, Fourier-domain optical coherence tomography, and multimodal adaptive optics imaging localized the visually significant changes seen in this disease at the level of the photoreceptors. These transient retinal changes specifically occur at the level of the inner segment ellipsoid and OS/RPE line. En face optical coherence tomography imaging provides a detailed, yet noninvasive method for following the convalescence of MEWDS and provides insight into the structural and functional relationship of this transient inflammatory retinal disease.

Autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytoma.

PubMed

Guerra, Ricardo Luz Leitão; Marback, Eduardo Ferrari; Silva, Igor Sandes Pessoa da; Maia Junior, Otacílio de Oliveira; Marback, Roberto Lorens

2014-01-01

The authors report fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (OCT) findings of two consecutive patients who presented with optic disk melanocytoma (ODM). A retrospective study was performed by reviewing medical records and ophthalmic imaging examinations. Optical coherence tomography findings were sloped and brightly reflective anterior tumor surface, adjacent retinal desorganization and abrupt posterior optical shadowing. Vitreous seeds were found in one patient. Fundus autofluorescence revealed outstanding hypoautofluorescence at the tumor area and isoautofluorescence at the remaining retina. Optical coherence tomography findings of the reported cases are consistent with those reported in the reviewed literature. Fundus autofluorescence has been used in the assessment of choroidal melanocytic tumors, but not yet in melanocytomas. We assume that this is the first report of these findings and believe that when its pattern has become clearly defined, fundus autofluorescence will be a useful tool to avoid misdiagnosis in suspicious cases and for follow-up.

Dark and white lesions observed in central serous chorioretinopathy on optical coherence tomography angiography.

PubMed

De Bats, Flore; Cornut, Pierre-Loïc; Wolff, Benjamin; Kodjikian, Laurent; Mauget-Faÿsse, Martine

2018-03-01

To describe abnormal dark (hyposignal) and white (hypersignal) lesions observed on optical coherence tomography angiography in central serous chorioretinopathy. Prospective, multicenter, and descriptive study including patients with active or quiescent central serous chorioretinopathy. All patients had undergone a complete ophthalmic examination. Abnormal dark lesions were detected as "dark spots" and "dark areas" on optical coherence tomography angiography. A "dark spot" could correspond to six different abnormalities: pigment epithelium detachment, subretinal deposit, "Lucency" within surrounding subretinal fibrin, choroidal cavitation, choroidal excavation, and choroidal fluid. A "dark area" could be related to a serous retinal detachment or choriocapillary compression. Abnormal white lesions were also detected: A "white spot" could correspond with the leaking point on fluorescein angiography or with hyper-reflective dots; A "white filamentous pattern" at the Brüch's membrane level corresponded to abnormal choroidal neovascular vessels. A semiology is described using optical coherence tomography angiography in central serous chorioretinopathy as abnormal dark and white lesions. Multimodal imaging is mandatory in addition to optical coherence tomography angiography to diagnose non-neovascular retinal and choroidal central serous chorioretinopathy lesions. However, optical coherence tomography angiography alone is helpful in detecting choroidal neovascular membrane in central serous chorioretinopathy.

In-line optical fiber metallic mirror reflector for monolithic common path optical coherence tomography probes.

PubMed

Singh, Kanwarpal; Reddy, Rohith; Sharma, Gargi; Verma, Yogesh; Gardecki, Joseph A; Tearney, Guillermo

2018-03-01

Endoscopic optical coherence tomography probes suffer from various artifacts due to dispersion imbalance and polarization mismatch between reference and sample arm light. Such artifacts can be minimized using a common path approach. In this work, we demonstrate a miniaturized common path probe for optical coherence tomography using an inline fiber mirror. A common path optical fiber probe suitable for performing high-resolution endoscopic optical coherence tomography imaging was developed. To achieve common path functionality, an inline fiber mirror was fabricated using a thin gold layer. A commercially available swept source engine was used to test the designed probe in a cadaver human coronary artery ex vivo. We achieved a sensitivity of 104 dB for this probe using a swept source optical coherence tomography system. To test the probe, images of a cadaver human coronary artery were obtained, demonstrating the quality that is comparable to those obtained by OCT systems with separate reference arms. Additionally, we demonstrate recovery of ranging depth by use of a Michelson interferometer in the detection path. We developed a miniaturized monolithic inline fiber mirror-based common path probe for optical coherence tomography. Owing to its simplicity, our design will be helpful in endoscopic applications that require high-resolution probes in a compact form factor while reducing system complexity. Lasers Surg. Med. 50:230-235, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Non-Gaussian statistics and optical rogue waves in stimulated Raman scattering.

PubMed

Monfared, Yashar E; Ponomarenko, Sergey A

2017-03-20

We explore theoretically and numerically optical rogue wave formation in stimulated Raman scattering inside a hydrogen filled hollow core photonic crystal fiber. We assume a weak noisy Stokes pulse input and explicitly construct the input Stokes pulse ensemble using the coherent mode representation of optical coherence theory, thereby providing a link between optical coherence and rogue wave theories. We show that the Stokes pulse peak power probability distribution function (PDF) acquires a long tail in the limit of nearly incoherent input Stokes pulses. We demonstrate a clear link between the PDF tail magnitude and the source coherence time. Thus, the latter can serve as a convenient parameter to control the former. We explain our findings qualitatively using the concepts of statistical granularity and global degree of coherence.

Monte Carlo modeling of spatial coherence: free-space diffraction

PubMed Central

Fischer, David G.; Prahl, Scott A.; Duncan, Donald D.

2008-01-01

We present a Monte Carlo method for propagating partially coherent fields through complex deterministic optical systems. A Gaussian copula is used to synthesize a random source with an arbitrary spatial coherence function. Physical optics and Monte Carlo predictions of the first- and second-order statistics of the field are shown for coherent and partially coherent sources for free-space propagation, imaging using a binary Fresnel zone plate, and propagation through a limiting aperture. Excellent agreement between the physical optics and Monte Carlo predictions is demonstrated in all cases. Convergence criteria are presented for judging the quality of the Monte Carlo predictions. PMID:18830335

Wavefront coherence area for predicting visual acuity of post-PRK and post-PARK refractive surgery patients

NASA Astrophysics Data System (ADS)

Garcia, Daniel D.; van de Pol, Corina; Barsky, Brian A.; Klein, Stanley A.

1999-06-01

Many current corneal topography instruments (called videokeratographs) provide an `acuity index' based on corneal smoothness to analyze expected visual acuity. However, post-refractive surgery patients often exhibit better acuity than is predicted by such indices. One reason for this is that visual acuity may not necessarily be determined by overall corneal smoothness but rather by having some part of the cornea able to focus light coherently onto the fovea. We present a new method of representing visual acuity by measuring the wavefront aberration, using principles from both ray and wave optics. For each point P on the cornea, we measure the size of the associated coherence area whose optical path length (OPL), from a reference plane to P's focus, is within a certain tolerance of the OPL for P. We measured the topographies and vision of 62 eyes of patients who had undergone the corneal refractive surgery procedures of photorefractive keratectomy (PRK) and photorefractive astigmatic keratectomy (PARK). In addition to high contrast visual acuity, our vision tests included low contrast and low luminance to test the contribution of the PRK transition zone. We found our metric for visual acuity to be better than all other metrics at predicting the acuity of low contrast and low luminance. However, high contrast visual acuity was poorly predicted by all of the indices we studied, including our own. The indices provided by current videokeratographs sometimes fail for corneas whose shape differs from simple ellipsoidal models. This is the case with post-PRK and post-PARK refractive surgery patients. Our alternative representation that displays the coherence area of the wavefront has considerable advantages, and promises to be a better predictor of low contrast and low luminance visual acuity than current shape measures.

A coherent optical feedback system for optical information processing

NASA Technical Reports Server (NTRS)

Jablonowski, D. P.; Lee, S. H.

1975-01-01

A unique optical feedback system for coherent optical data processing is described. With the introduction of feedback, the well-known transfer function for feedback systems is obtained in two dimensions. Operational details of the optical feedback system are given. Experimental results of system applications in image restoration, contrast control and analog computation are presented.

The variance of angle-of-arrival fluctuation of partially coherent Gaussian-Schell Model beam propagations in slant atmospheric turbulence

NASA Astrophysics Data System (ADS)

Tan, Zhenkun; Ke, Xizheng

2017-10-01

The variance of angle-of-arrival fluctuation of the partially coherent Gaussian-Schell Model (GSM) beam propagations in the slant path, based on the extended Huygens-Fresnel principle and the model of atmospheric refraction index structural constant proposed by the international telecommunication union-radio (ITU-R), has been investigated under the modified Hill turbulence model. The expression of that has been obtained. Firstly, the effects of optical wavelength, the inner-and-outer scale of the turbulence and turbulence intensity on the variance of angle-of-arrival fluctuation have been analyzed by comparing with the partially coherent GSM beam and the completely coherent Gaussian beam. Secondly, the variance of angle-of-arrival fluctuation has been compared with the von Karman spectrum and the modified Hill spectrum under the partially coherent GSM beam. Finally, the effects of beam waist radius and partial coherence length on the variance of angle-of-arrival of the collimated (focused) beam have been analyzed under the modified Hill turbulence model. The results show that the influence of the variance of angle-of-arrival fluctuation for the inner scale effect is larger than that of the outer scale effect. The variance of angle-of-arrival fluctuation under the modified Hill spectrum is larger than that of the von Karman spectrum. The influence of the waist radius on the variance of angle-of-arrival for the collimated beam is less than focused the beam. This study will provide a necessary theoretical basis for the experiments of partially coherent GSM beam propagation through atmosphere turbulence.

Optical subcarrier processing for Nyquist SCM signals via coherent spectrum overlapping in four-wave mixing with coherent multi-tone pump.

PubMed

Lu, Guo-Wei; Luís, Ruben S; Mendinueta, José Manuel Delgado; Sakamoto, Takahide; Yamamoto, Naokatsu

2018-01-22

As one of the promising multiplexing and multicarrier modulation technologies, Nyquist subcarrier multiplexing (Nyquist SCM) has recently attracted research attention to realize ultra-fast and ultra-spectral-efficient optical networks. In this paper, we propose and experimentally demonstrate optical subcarrier processing technologies for Nyquist SCM signals such as frequency conversion, multicast and data aggregation of subcarriers, through the coherent spectrum overlapping between subcarriers in four-wave mixing (FWM) with coherent multi-tone pump. The data aggregation is realized by coherently superposing or combining low-level subcarriers to yield high-level subcarriers in the optical field. Moreover, multiple replicas of the data-aggregated subcarriers and the subcarriers carrying the original data are obtained. In the experiment, two 5 Gbps quadrature phase-shift keying (QPSK) subcarriers are coherently combined to generate a 10 Gbps 16 quadrature amplitude modulation (QAM) subcarrier with frequency conversions through the FWM with coherent multi-tone pump. Less than 1 dB optical signal-to-noise ratio (OSNR) penalty variation is observed for the synthesized 16QAM subcarriers after the data aggregation. In addition, some subcarriers are kept in the original formats, QPSK, with a power penalty of less than 0.4 dB with respect to the original input subcarriers. The proposed subcarrier processing technology enables flexibility for spectral management in future dynamic optical networks.

Efficient dynamic coherence transfer relying on offset locking using optical phase-locked loop

NASA Astrophysics Data System (ADS)

Xie, Weilin; Dong, Yi; Bretenaker, Fabien; Shi, Hongxiao; Zhou, Qian; Xia, Zongyang; Qin, Jie; Zhang, Lin; Lin, Xi; Hu, Weisheng

2018-01-01

We design and experimentally demonstrate a highly efficient coherence transfer based on composite optical phaselocked loop comprising multiple feedback servo loops. The heterodyne offset-locking is achieved by conducting an acousto-optic frequency shifter in combination with the current tuning and the temperature controlling of the semiconductor laser. The adaptation of the composite optical phase-locked loop enables the tight coherence transfer from a frequency comb to a semiconductor laser in a fully dynamic manner.

A first demonstration of audio-frequency optical coherence elastography of tissue

NASA Astrophysics Data System (ADS)

Adie, Steven G.; Alexandrov, Sergey A.; Armstrong, Julian J.; Kennedy, Brendan F.; Sampson, David D.

2008-12-01

Optical elastography is aimed at using the visco-elastic properties of soft tissue as a contrast mechanism, and could be particularly suitable for high-resolution differentiation of tumour from surrounding normal tissue. We present a new approach to measure the effect of an applied stimulus in the kilohertz frequency range that is based on optical coherence tomography. We describe the approach and present the first in vivo optical coherence elastography measurements in human skin at audio excitation frequencies.

Contribution to the development of low frequency terahertz coherent Raman micro-spectroscopy and microscopy

NASA Astrophysics Data System (ADS)

Ujj, Laszlo

2018-06-01

We report the construction and characterization of a coherent Raman tabletop system utilizing a novel astigmatic optical focusing geometry, a broadband nanosecond optical parametric oscillator and volumetric Bragg filters assisting 3CBCRS measuring system for the first time. In order to illustrate the versatility of the measurements and reveal the molecular information obtainable, two well-characterized chemicals were selected. Polarization sensitive epi-detected 3CBCRS spectra of liquid CCl4 and calcite crystal were recorded and analyzed. An unexpected polarization dependence of the signals of the lowest frequency modes of CCl4 was observed. The 1122 third order susceptibility component was phase flipped. The non-resonant susceptibility normalized 1122 component was found to be larger than the 1111 component for the lowest vibrational modes. This anomalous comportment was attributable to the anisotropy Raman tensor invariant in the third order nonlinear susceptibility tensor.

Photodynamic therapy monitoring with optical coherence angiography

NASA Astrophysics Data System (ADS)

Sirotkina, M. A.; Matveev, L. A.; Shirmanova, M. V.; Zaitsev, V. Y.; Buyanova, N. L.; Elagin, V. V.; Gelikonov, G. V.; Kuznetsov, S. S.; Kiseleva, E. B.; Moiseev, A. A.; Gamayunov, S. V.; Zagaynova, E. V.; Feldchtein, F. I.; Vitkin, A.; Gladkova, N. D.

2017-02-01

Photodynamic therapy (PDT) is a promising modern approach for cancer therapy with low normal tissue toxicity. This study was focused on a vascular-targeting Chlorine E6 mediated PDT. A new angiographic imaging approach known as M-mode-like optical coherence angiography (MML-OCA) was able to sensitively detect PDT-induced microvascular alterations in the mouse ear tumour model CT26. Histological analysis showed that the main mechanisms of vascular PDT was thrombosis of blood vessels and hemorrhage, which agrees with angiographic imaging by MML-OCA. Relationship between MML-OCA-detected early microvascular damage post PDT (within 24 hours) and tumour regression/regrowth was confirmed by histology. The advantages of MML-OCA such as direct image acquisition, fast processing, robust and affordable system opto-electronics, and label-free high contrast 3D visualization of the microvasculature suggest attractive possibilities of this method in practical clinical monitoring of cancer therapies with microvascular involvement.

X-ray nanoprobes and diffraction-limited storage rings: opportunities and challenges of fluorescence tomography of biological specimens

PubMed Central

de Jonge, Martin D.; Ryan, Christopher G.; Jacobsen, Chris J.

2014-01-01

X-ray nanoprobes require coherent illumination to achieve optic-limited resolution, and so will benefit directly from diffraction-limited storage rings. Here, the example of high-resolution X-ray fluorescence tomography is focused on as one of the most voracious demanders of coherent photons, since the detected signal is only a small fraction of the incident flux. Alternative schemes are considered for beam delivery, sample scanning and detectors. One must consider as well the steps before and after the X-ray experiment: sample preparation and examination conditions, and analysis complexity due to minimum dose requirements and self-absorption. By understanding the requirements and opportunities for nanoscale fluorescence tomography, one gains insight into the R&D challenges in optics and instrumentation needed to fully exploit the source advances that diffraction-limited storage rings offer. PMID:25177992

Review of intraoperative optical coherence tomography: technology and applications [Invited

PubMed Central

Carrasco-Zevallos, Oscar M.; Viehland, Christian; Keller, Brenton; Draelos, Mark; Kuo, Anthony N.; Toth, Cynthia A.; Izatt, Joseph A.

2017-01-01

During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeon’s depth perception and visualization of instruments and sub-surface anatomy. Surgical procedures outside microsurgery, such as breast tumor resections, may also benefit from visualization of the sub-surface tissue structures. The widespread clinical adoption of optical coherence tomography (OCT) in ophthalmology and its growing prominence in other fields, such as cancer imaging, has motivated the development of intraoperative OCT for real-time tomographic visualization of surgical interventions. This article reviews key technological developments in intraoperative OCT and their applications in human surgery. We focus on handheld OCT probes, microscope-integrated OCT systems, and OCT-guided laser treatment platforms designed for intraoperative use. Moreover, we discuss intraoperative OCT adjuncts and processing techniques currently under development to optimize the surgical feedback derivable from OCT data. Lastly, we survey salient clinical studies of intraoperative OCT for human surgery. PMID:28663853

HYBRID simulations of diffraction-limited focusing with Kirkpatrick-Baez mirrors for a next-generation In Situ hard X-ray nanoprobe

DOE PAGES

Maser, Jorg; Shi, Xianbo; Reininger, Ruben; ...

2016-02-22

Next-generation hard X-ray nanoprobe beamlines such as the In Situ Nanoprobe (ISN) beamline being planned at the Advanced Photon Source aim at providing very high spatial resolution while also enabling very high focused flux, to study complex materials and devices using fast, multidimensional imaging across many length scales. The ISN will use diffractive optics to focus X-rays with a bandpass of ΔE/E = 10 –4 into a focal spot of 20 nm or below. Reflective optics in Kirkpatrick-Baez geometry will be used to focus X-rays with a bandpass as large as ΔE/E = 10 –2 into a focal spot ofmore » 50 nm. Diffraction-limited focusing with reflective optics is achieved by spatial filtering and use of a very long, vertically focusing mirror. Furthermore, to quantify the performance of the ISN beamline, we have simulated the propagation of both partially and fully coherent wavefronts from the undulator source, through the ISN beamline and into the mirror-based focal spot. Simulations were carried out using the recently developed software “HYBRID.”« less

A coaxially focused multi-mode beam for optical coherence tomography imaging with extended depth of focus (Conference Presentation)

NASA Astrophysics Data System (ADS)

Yin, Biwei; Liang, Chia-Pin; Vuong, Barry; Tearney, Guillermo J.

2017-02-01

Conventional OCT images, obtained using a focused Gaussian beam have a lateral resolution of approximately 30 μm and a depth of focus (DOF) of 2-3 mm, defined as the confocal parameter (twice of Gaussian beam Rayleigh range). Improvement of lateral resolution without sacrificing imaging range requires techniques that can extend the DOF. Previously, we described a self-imaging wavefront division optical system that provided an estimated one order of magnitude DOF extension. In this study, we further investigate the properties of the coaxially focused multi-mode (CAFM) beam created by this self-imaging wavefront division optical system and demonstrate its feasibility for real-time biological tissue imaging. Gaussian beam and CAFM beam fiber optic probes with similar numerical apertures (objective NA≈0.5) were fabricated, providing lateral resolutions of approximately 2 μm. Rigorous lateral resolution characterization over depth was performed for both probes. The CAFM beam probe was found to be able to provide a DOF that was approximately one order of magnitude greater than that of Gaussian beam probe. By incorporating the CAFM beam fiber optic probe into a μOCT system with 1.5 μm axial resolution, we were able to acquire cross-sectional images of swine small intestine ex vivo, enabling the visualization of subcellular structures, providing high quality OCT images over more than a 300 μm depth range.

T-2 in Coherent Optics: Collision, Dephasing Time, or Reciprocal Linewidth.

ERIC Educational Resources Information Center

Nettel, Stephen J.; Lempicki, Alexander

1979-01-01

Discusses how the frequency domain (line widths) and time domain (coherent optical transients) are related to the concept of transverse relaxation time in the study of high resolution optical spectroscopy. (HM)

Multi-contrast imaging of human posterior eye by Jones matrix optical coherence tomography

NASA Astrophysics Data System (ADS)

Yasuno, Yoshiaki

2017-04-01

A multi-contrast imaging of pathologic posterior eyes is demonstrated by Jones matrix optical coherence tomography (Jones matrix OCT). The Jones matrix OCT provides five tomographies, which includes scattering, local attenuation, birefringence, polarization uniformity, and optical coherence angiography, by a single scan. The hardware configuration, algorithms of the Jones matrix OCT as well as its application to ophthalmology is discussed.

Characterization of Light Lesion Paradigms and Optical Coherence Tomography as Tools to Study Adult Retina Regeneration in Zebrafish

PubMed Central

Weber, Anke; Hochmann, Sarah; Cimalla, Peter; Gärtner, Maria; Kuscha, Veronika; Hans, Stefan; Geffarth, Michaela; Kaslin, Jan; Koch, Edmund; Brand, Michael

2013-01-01

Light-induced lesions are a powerful tool to study the amazing ability of photoreceptors to regenerate in the adult zebrafish retina. However, the specificity of the lesion towards photoreceptors or regional differences within the retina are still incompletely understood. We therefore characterized the process of degeneration and regeneration in an established paradigm, using intense white light from a fluorescence lamp on swimming fish (diffuse light lesion). We also designed a new light lesion paradigm where light is focused through a microscope onto the retina of an immobilized fish (focused light lesion). Focused light lesion has the advantage of creating a locally restricted area of damage, with the additional benefit of an untreated control eye in the same animal. In both paradigms, cell death is observed as an immediate early response, and proliferation is initiated around 2 days post lesion (dpl), peaking at 3 dpl. We furthermore find that two photoreceptor subtypes (UV and blue sensitive cones) are more susceptible towards intense white light than red/green double cones and rods. We also observed specific differences within light lesioned areas with respect to the process of photoreceptor degeneration: UV cone debris is removed later than any other type of photoreceptor in light lesions. Unspecific damage to retinal neurons occurs at the center of a focused light lesion territory, but not in the diffuse light lesion areas. We simulated the fish eye optical properties using software simulation, and show that the optical properties may explain the light lesion patterns that we observe. Furthermore, as a new tool to study retinal degeneration and regeneration in individual fish in vivo, we use spectral domain optical coherence tomography. Collectively, the light lesion and imaging assays described here represent powerful tools for studying degeneration and regeneration processes in the adult zebrafish retina. PMID:24303018

Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue.

PubMed

Telenkov, Sergey A; Dave, Digant P; Sethuraman, Shriram; Akkin, Taner; Milner, Thomas E

2004-01-07

We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.

Coherent startup of an infrared free-electron laser

NASA Astrophysics Data System (ADS)

Jaroszynski, D. A.; Bakker, R. J.; van der Meer, A. F. G.; Oepts, D.; van Amersfoort, P. W.

1993-12-01

Coherent enhancement of the spontaneous undulator radiation by several orders of magnitude has been observed in a free-electron laser at wavelengths from 40 to 100 μm. The coherent emission can be explained by details of the electron-beam micropulse structure. Furthermore, it has been found that the phase of the optical micropulses is fixed by the electron pulse structure and that the coherence extends over successive optical micropulses, which gives rise to interference effects as a function of the optical cavity length in a laser oscillator.

Blind operation of optical astronomical interferometers options and predicted performance

NASA Astrophysics Data System (ADS)

Beckers, Jacques M.

1991-01-01

Maximum sensitivity for optical interferometers is achieved only when the optical path lengths between the different arms can be equalized without using interference fringes on the research object itself. This is called 'blind operation' of the interferometer. This paper examines different options to achieve this, focusing on the application to the Very Large Telescope Interferometer (VLTI). It is proposed that blind operation should be done using a so-called coherence autoguider, working on an unresolved star of magnitude V = 11-13 within the isoplanatic patch for coherencing, which has a diameter of about 1 deg. Estimates of limiting magnitudes for the VLTI are also derived.

A landmark recognition and tracking experiment for flight on the Shuttle/Advanced Technology Laboratory (ATL)

NASA Technical Reports Server (NTRS)

Welch, J. D.

1975-01-01

The preliminary design of an experiment for landmark recognition and tracking from the Shuttle/Advanced Technology Laboratory is described. It makes use of parallel coherent optical processing to perform correlation tests between landmarks observed passively with a telescope and previously made holographic matched filters. The experimental equipment including the optics, the low power laser, the random access file of matched filters and the electro-optical readout device are described. A real time optically excited liquid crystal device is recommended for performing the input non-coherent optical to coherent optical interface function. A development program leading to a flight experiment in 1981 is outlined.

Multi-aperture all-fiber active coherent beam combining for free-space optical communication receivers.

PubMed

Yang, Yan; Geng, Chao; Li, Feng; Huang, Guan; Li, Xinyang

2017-10-30

Multi-aperture receiver with optical combining architecture is an effective approach to overcome the turbulent atmosphere effect on the performance of the free-space optical (FSO) communications, in which how to combine the multiple laser beams received by the sub-apertures efficiently is one of the key technologies. In this paper, we focus on the combining module based on fiber couplers, and propose the all-fiber coherent beam combining (CBC) with two architectures by using active phase locking. To validate the feasibility of the proposed combining module, corresponding experiments and simulations on the CBC of four laser beams are carried out. The experimental results show that the phase differences among the input beams can be compensated and the combining efficiency can be stably promoted by active phase locking in CBC with both of the two architectures. The simulation results show that the combining efficiency fluctuates when turbulent atmosphere is considered, and the effectiveness of the combining module decreases as the turbulence increases. We believe that the combining module proposed in this paper has great potential, and the results can provide significant advices for researchers when building such a multi-aperture receiver with optical combining architecture for FSO commutation systems.

Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics.

PubMed

Salas, Matthias; Augustin, Marco; Ginner, Laurin; Kumar, Abhishek; Baumann, Bernhard; Leitgeb, Rainer; Drexler, Wolfgang; Prager, Sonja; Hafner, Julia; Schmidt-Erfurth, Ursula; Pircher, Michael

2017-01-01

The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some limitations of this technology such as shadowing and projection artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density based on OCTA alone can be misleading. In this paper we compare the performance of AO-OCT, AO-OCTA and OCTA for imaging retinal vasculature. The improved transverse resolution and the reduced depth of focus of AO-OCT and AO-OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina. The comparison is done on images recorded in healthy volunteers and in diabetic patients with distinct pathologies of the retinal microvasculature.

Surface-enhanced FAST CARS: en route to quantum nano-biophotonics

NASA Astrophysics Data System (ADS)

Voronine, Dmitri V.; Zhang, Zhenrong; Sokolov, Alexei V.; Scully, Marlan O.

2018-02-01

Quantum nano-biophotonics as the science of nanoscale light-matter interactions in biological systems requires developing new spectroscopic tools for addressing the challenges of detecting and disentangling weak congested optical signals. Nanoscale bio-imaging addresses the challenge of the detection of weak resonant signals from a few target biomolecules in the presence of the nonresonant background from many undesired molecules. In addition, the imaging must be performed rapidly to capture the dynamics of biological processes in living cells and tissues. Label-free non-invasive spectroscopic techniques are required to minimize the external perturbation effects on biological systems. Various approaches were developed to satisfy these requirements by increasing the selectivity and sensitivity of biomolecular detection. Coherent anti-Stokes Raman scattering (CARS) and surface-enhanced Raman scattering (SERS) spectroscopies provide many orders of magnitude enhancement of chemically specific Raman signals. Femtosecond adaptive spectroscopic techniques for CARS (FAST CARS) were developed to suppress the nonresonant background and optimize the efficiency of the coherent optical signals. This perspective focuses on the application of these techniques to nanoscale bio-imaging, discussing their advantages and limitations as well as the promising opportunities and challenges of the combined coherence and surface enhancements in surface-enhanced coherent anti-Stokes Raman scattering (SECARS) and tip-enhanced coherent anti-Stokes Raman scattering (TECARS) and the corresponding surface-enhanced FAST CARS techniques. Laser pulse shaping of near-field excitations plays an important role in achieving these goals and increasing the signal enhancement.

Time-frequency analysis in optical coherence tomography for technical objects examination

NASA Astrophysics Data System (ADS)

StrÄ kowski, Marcin R.; Kraszewski, Maciej; Trojanowski, Michał; Pluciński, Jerzy

2014-05-01

Optical coherence tomography (OCT) is one of the most advanced optical measurement techniques for complex structure visualization. The advantages of OCT have been used for surface and subsurface defect detection in composite materials, polymers, ceramics, non-metallic protective coatings, and many more. Our research activity has been focused on timefrequency spectroscopic analysis in OCT. It is based on time resolved spectral analysis of the backscattered optical signal delivered by the OCT. The time-frequency method gives spectral characteristic of optical radiation backscattered or backreflected from the particular points inside the tested device. This provides more information about the sample, which are useful for further analysis. Nowadays, the applications of spectroscopic analysis for composite layers characterization or tissue recognition have been reported. During our studies we have found new applications of spectroscopic analysis. We have used this method for thickness estimation of thin films, which are under the resolution of OCT. Also, we have combined the spectroscopic analysis with polarization sensitive OCT (PS-OCT). This approach enables to obtain a multiorder retardation value directly and may become a breakthrough in PS-OCT measurements of highly birefringent media. In this work, we present the time-frequency spectroscopic algorithms and their applications for OCT. Also, the theoretical simulations and measurement validation of this method are shown.

Coherent Amplification of Ultrafast Molecular Dynamics in an Optical Oscillator

NASA Astrophysics Data System (ADS)

Aharonovich, Igal; Pe'er, Avi

2016-02-01

Optical oscillators present a powerful optimization mechanism. The inherent competition for the gain resources between possible modes of oscillation entails the prevalence of the most efficient single mode. We harness this "ultrafast" coherent feedback to optimize an optical field in time, and show that, when an optical oscillator based on a molecular gain medium is synchronously pumped by ultrashort pulses, a temporally coherent multimode field can develop that optimally dumps a general, dynamically evolving vibrational wave packet, into a single vibrational target state. Measuring the emitted field opens a new window to visualization and control of fast molecular dynamics. The realization of such a coherent oscillator with hot alkali dimers appears within experimental reach.

Squeezed light in an optical parametric oscillator network with coherent feedback quantum control.

PubMed

Crisafulli, Orion; Tezak, Nikolas; Soh, Daniel B S; Armen, Michael A; Mabuchi, Hideo

2013-07-29

We present squeezing and anti-squeezing spectra of the output from a degenerate optical parametric oscillator (OPO) network arranged in different coherent quantum feedback configurations. One OPO serves as a quantum plant, the other as a quantum controller. The addition of coherent feedback enables shaping of the output squeezing spectrum of the plant, and is found to be capable of pushing the frequency of maximum squeezing away from the optical driving frequency and broadening the spectrum over a wider frequency band. The experimental results are in excellent agreement with the developed theory, and illustrate the use of coherent quantum feedback to engineer the quantum-optical properties of the plant OPO output.

Transmission and full-band coherent detection of polarization-multiplexed all-optical Nyquist signals generated by Sinc-shaped Nyquist pulses

PubMed Central

Zhang, Junwen; Yu, Jianjun; Chi, Nan

2015-01-01

All optical method is considered as a promising technique for high symbol rate Nyquist signal generation, which has attracted a lot of research interests for high spectral-efficiency and high-capacity optical communication system. In this paper, we extend our previous work and report the fully experimental demonstration of polarization-division multiplexed (PDM) all-optical Nyquist signal generation based on Sinc-shaped Nyquist pulse with advanced modulation formats, fiber-transmission and single-receiver full-band coherent detection. Using this scheme, we have successfully demonstrated the generation, fiber transmission and single-receiver full-band coherent detection of all-optical Nyquist PDM-QPSK and PDM-16QAM signals up to 125-GBaud. 1-Tb/s single-carrier PDM-16QAM signal generation and full-band coherent detection is realized, which shows the advantage and feasibility of the single-carrier all-optical Nyquist signals. PMID:26323238

Optical coherence of 166Er:7LiYF4 crystal below 1 K

NASA Astrophysics Data System (ADS)

Kukharchyk, N.; Sholokhov, D.; Morozov, O.; Korableva, S. L.; Kalachev, A. A.; Bushev, P. A.

2018-02-01

We explore optical coherence and spin dynamics of an isotopically purified 166Er:7LiYF4 crystal below 1 K and at weak magnetic fields < 0.3T. Crystals were grown in our lab and demonstrate narrow inhomogeneous optical broadening down to 16 MHz. Solid-state atomic ensembles with such narrow linewidths are very attractive for implementing of off-resonant Raman quantum memory and for the interfacing of superconducting quantum circuits and telecom C-band optical photons. Both applications require a low magnetic field of ∼10 mT. However, at conventional experimental temperatures T > 1.5 K, optical coherence of Er:LYF crystal attains ≃ 10 μ {{s}} time scale only at strong magnetic fields above 1.5 T. In the present work, we demonstrate that the deep freezing of Er:LYF crystal below 1 K results in the increase of optical coherence time to ≃ 100 μ {{s}} at weak fields.

High-brightness laser imaging with tunable speckle reduction enabled by electroactive micro-optic diffusers.

PubMed

Farrokhi, Hamid; Rohith, Thazhe Madam; Boonruangkan, Jeeranan; Han, Seunghwoi; Kim, Hyunwoong; Kim, Seung-Woo; Kim, Young-Jin

2017-11-10

High coherence of lasers is desirable in high-speed, high-resolution, and wide-field imaging. However, it also causes unavoidable background speckle noise thus degrades the image quality in traditional microscopy and more significantly in interferometric quantitative phase imaging (QPI). QPI utilizes optical interference for high-precision measurement of the optical properties where the speckle can severely distort the information. To overcome this, we demonstrated a light source system having a wide tunability in the spatial coherence over 43% by controlling the illumination angle, scatterer's size, and the rotational speed of an electroactive-polymer rotational micro-optic diffuser. Spatially random phase modulation was implemented for the lower speckle imaging with over a 50% speckle reduction without a significant degradation in the temporal coherence. Our coherence control technique will provide a unique solution for a low-speckle, full-field, and coherent imaging in optically scattering media in the fields of healthcare sciences, material sciences and high-precision engineering.

All-optical control of long-lived nuclear spins in rare-earth doped nanoparticles.

PubMed

Serrano, D; Karlsson, J; Fossati, A; Ferrier, A; Goldner, P

2018-05-29

Nanoscale systems that coherently couple to light and possess spins offer key capabilities for quantum technologies. However, an outstanding challenge is to preserve properties, and especially optical and spin coherence lifetimes, at the nanoscale. Here, we report optically controlled nuclear spins with long coherence lifetimes (T 2 ) in rare-earth-doped nanoparticles. We detect spins echoes and measure a spin coherence lifetime of 2.9 ± 0.3 ms at 5 K under an external magnetic field of 9 mT, a T 2 value comparable to those obtained in bulk rare-earth crystals. Moreover, we achieve spin T 2 extension using all-optical spin dynamical decoupling and observe high fidelity between excitation and echo phases. Rare-earth-doped nanoparticles are thus the only nano-material in which optically controlled spins with millisecond coherence lifetimes have been reported. These results open the way to providing quantum light-atom-spin interfaces with long storage time within hybrid architectures.

Applications of Optical Coherence Tomography in Pediatric Clinical Neuroscience

PubMed Central

Avery, Robert A.; Rajjoub, Raneem D.; Trimboli-Heidler, Carmelina; Waldman, Amy T.

2015-01-01

For nearly two centuries, the ophthalmoscope has permitted examination of the retina and optic nerve—the only axons directly visualized by the physician. The retinal ganglion cells project their axons, which travel along the innermost retina to form the optic nerve, marking the beginning of the anterior visual pathway. Both the structure and function of the visual pathway are essential components of the neurologic examination as it can be involved in numerous acquired, congenital and genetic central nervous system conditions. The development of optical coherence tomography now permits the pediatric neuroscientist to visualize and quantify the optic nerve and retinal layers with unprecedented resolution. As optical coherence tomography becomes more accessible and integrated into research and clinical care, the pediatric neuroscientist may have the opportunity to utilize and/or interpret results from this device. This review describes the basic technical features of optical coherence tomography and highlights its potential clinical and research applications in pediatric clinical neuroscience including optic nerve swelling, optic neuritis, tumors of the visual pathway, vigabatrin toxicity, nystagmus, and neurodegenerative conditions. PMID:25803824

Applications of optical coherence tomography in pediatric clinical neuroscience.

PubMed

Avery, Robert A; Rajjoub, Raneem D; Trimboli-Heidler, Carmelina; Waldman, Amy T

2015-04-01

For nearly two centuries, the ophthalmoscope has permitted examination of the retina and optic nerve-the only axons directly visualized by the physician. The retinal ganglion cells project their axons, which travel along the innermost retina to form the optic nerve, marking the beginning of the anterior visual pathway. Both the structure and function of the visual pathway are essential components of the neurologic examination as it can be involved in numerous acquired, congenital and genetic central nervous system conditions. The development of optical coherence tomography now permits the pediatric neuroscientist to visualize and quantify the optic nerve and retinal layers with unprecedented resolution. As optical coherence tomography becomes more accessible and integrated into research and clinical care, the pediatric neuroscientist may have the opportunity to utilize and/or interpret results from this device. This review describes the basic technical features of optical coherence tomography and highlights its potential clinical and research applications in pediatric clinical neuroscience including optic nerve swelling, optic neuritis, tumors of the visual pathway, vigabatrin toxicity, nystagmus, and neurodegenerative conditions. Georg Thieme Verlag KG Stuttgart · New York.

Passively-coupled, low-coherence interferometric duct profiling with an astigmatism-corrected conical mirror.

PubMed

Ford, Helen D; Tatam, Ralph P

2017-04-17

Duct-profiling in test samples up to 25 mm in diameter has been demonstrated using a passive, low-coherence probe head with a depth resolution of 7.8 μm, incorporating an optical-fibre-linked conical mirror addressed by a custom-built array of single-mode fibres. Zemax modelling, and experimental assessment of instrument performance, show that degradation of focus, resulting from astigmatism introduced by the conical mirror, is mitigated by the introduction of a novel lens element. This enables a good beam focus to be achieved at distances of tens of millimetres from the cone axis, not achievable when the cone is used alone. Incorporation of the additional lens element is shown to provide a four-fold improvement in lateral imaging resolution, when compared with reflection from the conical mirror alone.

OPTICAL PROCESSING OF INFORMATION: Potential applications of quasi-cw partially coherent radiation in optical data recording and processing

NASA Astrophysics Data System (ADS)

Volkov, L. V.; Larkin, A. I.

1994-04-01

Theoretical and experimental investigations are reported of the potential applications of quasi-cw partially coherent radiation in optical systems based on diffraction—interference principles. It is shown that the spectral characteristics of quasi-cw radiation influence the data-handling capabilities of a holographic correlator and of a partially coherent holographic system for data acquisition. Relevant experimental results are reported.

Developments in Coherent Perfect Polarization Rotation

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Andrews, James; Zhou, Chaunhong; Baker, Michael

2015-05-01

Coherent Perfect Polarization Rotation (CPR) is a useful technique akin to Coherent Perfect Absorption (CPA, also known as the anti-laser) but that results in very high efficiency optical mode conversion. We describe the analysis of recent experimental data from our CPR testbed, the use of CPR in miniaturizing optical isolators and CPR phenomena in non-linear optics. Work supported by the N.S.F. under Grant No. ECCS-1360725.

Rat brain imaging using full field optical coherence microscopy with short multimode fiber probe

NASA Astrophysics Data System (ADS)

Sato, Manabu; Saito, Daisuke; Kurotani, Reiko; Abe, Hiroyuki; Kawauchi, Satoko; Sato, Shunichi; Nishidate, Izumi

2017-02-01

We demonstrated FF OCM(full field optical coherence microscopy) using an ultrathin forward-imaging SMMF (short multimode fiber) probe of 50 μm core diameter, 125 μm diameter, and 7.4 mm length, which is a typical graded-index multimode fiber for optical communications. The axial resolution was measured to be 2.20 μm, which is close to the calculated axial resolution of 2.06 μm. The lateral resolution was evaluated to be 4.38 μm using a test pattern. Assuming that the FWHM of the contrast is the DOF (depth of focus), the DOF of the signal is obtained at 36 μm and that of the OCM is 66 μm. The contrast of the OCT images was 6.1 times higher than that of the signal images due to the coherence gate. After an euthanasia the rat brain was resected and cut at 2.6mm tail from Bregma. Contacting SMMF to the primary somatosensory cortex and the agranular insular cortex of ex vivo brain, OCM images of the brain were measured 100 times with 2μm step. 3D OCM images of the brain were measured, and internal structure information was obtained. The feasibility of an SMMF as an ultrathin forward-imaging probe in full-field OCM has been demonstrated.

Noncontact phase-sensitive dynamic optical coherence elastography at megahertz rate

NASA Astrophysics Data System (ADS)

Singh, Manmohan; Wu, Chen; Liu, Chih-Hao; Li, Jiasong; Schill, Alexander; Nair, Achuth; Kistenev, Yury V.; Larin, Kirill V.

2016-03-01

Dynamic optical coherence elastography (OCE) techniques have shown great promise at quantitatively obtaining the biomechanical properties of tissue. However, the majority of these techniques have required multiple temporal OCT acquisitions (M-B mode) and corresponding excitations, which lead to clinically unfeasible acquisition times and potential tissue damage. Furthermore, the large data sets and extended laser exposures hinder their translation to the clinic, where patient discomfort and safety are critical criteria. In this work we demonstrate noncontact true kilohertz frame-rate dynamic optical coherence elastography by directly imaging a focused air-pulse induced elastic wave with a home-built phase-sensitive OCE system based on a 4X buffered Fourier Domain Mode Locked swept source laser with an A-scan rate of ~1.5 MHz. The elastic wave was imaged at a frame rate of ~7.3 kHz using only a single excitation. In contrast to previous techniques, successive B-scans were acquired over the measurement region (B-M mode) in this work. The feasibility of this method was validated by quantifying the elasticity of tissue-mimicking agar phantoms as well as porcine corneas ex vivo at different intraocular pressures. The results demonstrate that this method can acquire a depth-resolved elastogram in milliseconds. The reduced data set enabled a rapid elasticity assessment, and the ultra-fast acquisition speed allowed for a clinically safe laser exposure to the cornea.

Proof of concept demonstration for coherent beam pattern measurements of KID detectors

NASA Astrophysics Data System (ADS)

Davis, Kristina K.; Baryshev, Andrey M.; Jellema, Willem; Yates, Stephen J. C.; Ferrari, Lorenza; Baselmans, Jochem J. A.

2016-07-01

Here we summarize the initial results from a complex field radiation pattern measurement of a kinetic inductance detector instrument. These detectors are phase insensitive and have thus been limited to scalar, or amplitude-only, beam measurements. Vector beam scans, of both amplitude and phase, double the information received in comparison to scalar beam scans. Scalar beam measurements require multiple scans at varying distances along the optical path of the receiver to fully constrain the divergence angle of the optical system and locate the primary focus. Vector scans provide this information with a single scan, reducing the total measurement time required for new systems and also limiting the influence of system instabilities. The vector scan can be taken at any point along the optical axis of the system including the near-field, which makes beam measurements possible for large systems at high frequencies where these measurements may be inconceivable to be tested in-situ. Therefore, the methodology presented here should enable common heterodyne analysis for direct detector instruments. In principle, this coherent measurement strategy allows phase dependent analysis to be performed on any direct-detect receiver instrument.

Ophthalmological OCT measuring arm design

NASA Astrophysics Data System (ADS)

Xu, Xiaonan; Gao, Jiansong; Guo, Jihua; Xue, Ping

2002-06-01

This paper presents a novel ophthamological optical coherence tomography detecting instrument that we design and introduces measuring arm emphatically. For the glaucoma is very common in the orient, this system can achieve both the eyeground detection and the canthus detection. And it combines the cranny lamp's conventional detection with optical coherence tomography. In order to gain the best resolution and the largest scanning range in the OCT detection, we find the optical system should obey these principles in the measuring arm design: (i) the parallel light from the collimator goes through the lens and focuses on the slot of the cranny lamp. The movement of the scanning point produced by the scanner is carrying on along the slot. (Ii) In the whole light route, the scanner images on the laser object lens of the OCT. The center light of the infrared goes through the center of the object lens all the time. Considering all the system, this design has a longitudinal resolution of 15micrometers , and a transverse resolution of 20micrometers at imaging velocity of 4 frames per second.

Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics

PubMed Central

Fang, Qi; Curatolo, Andrea; Wijesinghe, Philip; Yeow, Yen Ling; Hamzah, Juliana; Noble, Peter B.; Karnowski, Karol; Sampson, David D.; Ganss, Ruth; Kim, Jun Ki; Lee, Woei M.; Kennedy, Brendan F.

2017-01-01

In this paper, we describe a technique capable of visualizing mechanical properties at the cellular scale deep in living tissue, by incorporating a gradient-index (GRIN)-lens micro-endoscope into an ultrahigh-resolution optical coherence elastography system. The optical system, after the endoscope, has a lateral resolution of 1.6 µm and an axial resolution of 2.2 µm. Bessel beam illumination and Gaussian mode detection are used to provide an extended depth-of-field of 80 µm, which is a 4-fold improvement over a fully Gaussian beam case with the same lateral resolution. Using this system, we demonstrate quantitative elasticity imaging of a soft silicone phantom containing a stiff inclusion and a freshly excised malignant murine pancreatic tumor. We also demonstrate qualitative strain imaging below the tissue surface on in situ murine muscle. The approach we introduce here can provide high-quality extended-focus images through a micro-endoscope with potential to measure cellular-scale mechanics deep in tissue. We believe this tool is promising for studying biological processes and disease progression in vivo. PMID:29188108

Coherent optical excitations in superconducting qubit chain

NASA Astrophysics Data System (ADS)

Ian, Hou; Liu, Yu-Xi

2012-06-01

In the recent years, the theories of quantum optics have been borrowed to study the flows of electron pairs and their interactions with the circuit photon in the superconducting qubit circuits. These studies bring about new theories of quantum optics, such as the tunable electromagnetically induced transparency effect, peculiar to the Cooper pairs in circuits. In this talk, we focus on a special type of superconducting qubit circuits: superconducting qubit chain (SQC), which comprises dozens of qubits linearly placed along a stripline resonator. Since the dimensions of the qubits and the stripline have made their interactions inhomogeneous, the SQC cannot be diagonalized using the usual Dicke model. We present a new theoretical method, the deformation-projection method, for the exact diagonalization of the collective excitations of the qubits. This method allows us to predict that these excitations emulate the behaviors of Wannier and Frenckel excitons in the solid-state systems. The spontaneous emissions from the individual qubits in SQC are relayed to their neighbors, eventually arriving at a coherent emission, known as superradiance. We present a quantum relay model, which is crucial to quantum information processing, based on this finding.

Motionless active depth from defocus system using smart optics for camera autofocus applications

NASA Astrophysics Data System (ADS)

Amin, M. Junaid; Riza, Nabeel A.

2016-04-01

This paper describes a motionless active Depth from Defocus (DFD) system design suited for long working range camera autofocus applications. The design consists of an active illumination module that projects a scene illuminating coherent conditioned optical radiation pattern which maintains its sharpness over multiple axial distances allowing an increased DFD working distance range. The imager module of the system responsible for the actual DFD operation deploys an electronically controlled variable focus lens (ECVFL) as a smart optic to enable a motionless imager design capable of effective DFD operation. An experimental demonstration is conducted in the laboratory which compares the effectiveness of the coherent conditioned radiation module versus a conventional incoherent active light source, and demonstrates the applicability of the presented motionless DFD imager design. The fast response and no-moving-parts features of the DFD imager design are especially suited for camera scenarios where mechanical motion of lenses to achieve autofocus action is challenging, for example, in the tiny camera housings in smartphones and tablets. Applications for the proposed system include autofocus in modern day digital cameras.

Optical amplifiers for coherent lidar

NASA Technical Reports Server (NTRS)

Fork, Richard

1996-01-01

We examine application of optical amplification to coherent lidar for the case of a weak return signal (a number of quanta of the return optical field close to unity). We consider the option that has been explored to date, namely, incorporation of an optical amplifier operated in a linear manner located after reception of the signal and immediately prior to heterodyning and photodetection. We also consider alternative strategies where the coherent interaction, the nonlinear processes, and the amplification are not necessarily constrained to occur in the manner investigated to date. We include the complications that occur because of mechanisms that occur at the level of a few, or one, quantum excitation. Two factors combine in the work to date that limit the value of the approach. These are: (1) the weak signal tends to require operation of the amplifier in the linear regime where the important advantages of nonlinear optical processing are not accessed, (2) the linear optical amplifier has a -3dB noise figure (SN(out)/SN(in)) that necessarily degrades the signal. Some improvement is gained because the gain provided by the optical amplifier can be used to overcome losses in the heterodyned process and photodetection. The result, however, is that introduction of an optical amplifier in a well optimized coherent lidar system results in, at best, a modest improvement in signal to noise. Some improvement may also be realized on incorporating more optical components in a coherent lidar system for purely practical reasons. For example, more compact, lighter weight, components, more robust alignment, or more rapid processing may be gained. We further find that there remain a number of potentially valuable, but unexplored options offered both by the rapidly expanding base of optical technology and the recent investigation of novel nonlinear coherent interference phenomena occurring at the single quantum excitation level. Key findings are: (1) insertion of linear optical amplifiers in well optimized conventional lidar systems offers modest improvements, at best, (2) the practical advantages of optical amplifiers, especially fiber amplifiers, such as ease of alignment, compactness, efficiency, lightweight, etc., warrant further investigation for coherent lidar, (3) the possibility of more fully optical lidar systems should be explored, (4) advantages gained by use of coherent interference of optical fields at the level of one, or a few, signal quanta should be explored, (5) amplification without inversion, population trapping, and use of electromagnetic induced transparency warrant investigation in connection with coherent lidar, (6) these new findings are probably more applicable to earth related NASA work, although applications to deep space should not be excluded, and (7) our own work in the Ultrafast Laboratory at UAH along some of the above lines of investigation, may be useful.

Preliminary study on combined pharmacological and laser treatment in optic pit serous maculopathy after literature review.

PubMed

Nebbioso, M; Dapoto, L; Lenarduzzi, F; Belcaro, G; Malagola, R

2012-12-01

The pit of the optic nerve head (ON) is a rare congenital defect that sometimes presents itself with a maculopathy of various neuroretinal layers for unknown reason. This study was focused, before and after pharmacological and parasurgical treatment, on the structural and functional visual assessment in a patient with optic pit maculopathy (OPM). In order to achieve this the latest generation of hi-tech diagnostic tests were used, such as Spectral-Domain Optical Coherence Tomography (SD-OCT), Visual Evoked Potentials (VEP), full-field Electroretinography (ERG), multifocal ERG (mfERG), Microperimetry (MP-1), Standard Automated Perimetry (SAP), Fluorescein Angiography (FA) and Indocyanine Green Angiography (ICG). The research was conducted through a review of past and recent literature.

Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography

NASA Astrophysics Data System (ADS)

Nguyen, Thu-Mai; Arnal, Bastien; Song, Shaozhen; Huang, Zhihong; Wang, Ruikang K.; O'Donnell, Matthew

2015-01-01

Investigating the elasticity of ocular tissue (cornea and intraocular lens) could help the understanding and management of pathologies related to biomechanical deficiency. In previous studies, we introduced a setup based on optical coherence tomography for shear wave elastography (SWE) with high resolution and high sensitivity. SWE determines tissue stiffness from the propagation speed of shear waves launched within tissue. We proposed acoustic radiation force to remotely induce shear waves by focusing an ultrasound (US) beam in tissue, similar to several elastography techniques. Minimizing the maximum US pressure is essential in ophthalmology for safety reasons. For this purpose, we propose a pulse compression approach. It utilizes coded US emissions to generate shear waves where the energy is spread over a long emission, and then numerically compressed into a short, localized, and high-energy pulse. We used a 7.5-MHz single-element focused transducer driven by coded excitations where the amplitude is modulated by a linear frequency-swept square wave (1 to 7 kHz). An inverse filter approach was used for compression. We demonstrate the feasibility of performing shear wave elastography measurements in tissue-mimicking phantoms at low US pressures (mechanical index <0.6).

Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography

PubMed Central

Nguyen, Thu-Mai; Arnal, Bastien; Song, Shaozhen; Huang, Zhihong; Wang, Ruikang K.; O’Donnell, Matthew

2015-01-01

Abstract. Investigating the elasticity of ocular tissue (cornea and intraocular lens) could help the understanding and management of pathologies related to biomechanical deficiency. In previous studies, we introduced a setup based on optical coherence tomography for shear wave elastography (SWE) with high resolution and high sensitivity. SWE determines tissue stiffness from the propagation speed of shear waves launched within tissue. We proposed acoustic radiation force to remotely induce shear waves by focusing an ultrasound (US) beam in tissue, similar to several elastography techniques. Minimizing the maximum US pressure is essential in ophthalmology for safety reasons. For this purpose, we propose a pulse compression approach. It utilizes coded US emissions to generate shear waves where the energy is spread over a long emission, and then numerically compressed into a short, localized, and high-energy pulse. We used a 7.5-MHz single-element focused transducer driven by coded excitations where the amplitude is modulated by a linear frequency-swept square wave (1 to 7 kHz). An inverse filter approach was used for compression. We demonstrate the feasibility of performing shear wave elastography measurements in tissue-mimicking phantoms at low US pressures (mechanical index <0.6). PMID:25554970

Optical to optical interface device

NASA Technical Reports Server (NTRS)

Oliver, D. S.; Vohl, P.; Nisenson, P.

1972-01-01

The development, fabrication, and testing of a preliminary model of an optical-to-optical (noncoherent-to-coherent) interface device for use in coherent optical parallel processing systems are described. The developed device demonstrates a capability for accepting as an input a scene illuminated by a noncoherent radiation source and providing as an output a coherent light beam spatially modulated to represent the original noncoherent scene. The converter device developed under this contract employs a Pockels readout optical modulator (PROM). This is a photosensitive electro-optic element which can sense and electrostatically store optical images. The stored images can be simultaneously or subsequently readout optically by utilizing the electrostatic storage pattern to control an electro-optic light modulating property of the PROM. The readout process is parallel as no scanning mechanism is required. The PROM provides the functions of optical image sensing, modulation, and storage in a single active material.

Low-cost coherent receiver for long-reach optical access network using single-ended detection.

PubMed

Zhang, Xuebing; Li, Zhaohui; Li, Jianping; Yu, Changyuan; Lau, Alan Pak Tao; Lu, Chao

2014-09-15

A low-cost coherent receiver using two 2×3 optical hybrids and single-ended detection is proposed for long-reach optical access network. This structure can detect the two polarization components of polarization division multiplexing (PDM) signals. Polarization de-multiplexing and signal-to-signal beat interference (SSBI) cancellation are realized by using only three photodiodes. Simulation results for 40 Gb/s PDM-OFDM transmissions indicate that the low-cost coherent receiver has 3.2 dB optical signal-to-noise ratio difference compared with the theoretical value.

Use of optical coherence topography for objective assessment of fundus torsion.

PubMed

Sophocleous, Sophocles

2017-02-23

Objective assessment of fundus torsion is currently performed with indirect ophthalmoscopy or fundus photography. Using the infrared image of the macular scan of the optical coherence tomography one can assess the presence and amount of fundus torsion. In addition, the line scan through the fovea can be used as a reference to confirm the position of the foveal pit in relation to the optic nerve head. Two cases are used to demonstrate how to assess fundus torsion with the use of the optical coherence tomography. 2017 BMJ Publishing Group Ltd.

Overlapped optics induced perfect coherent effects.

PubMed

Li, Jian Jie; Zang, Xiao Fei; Mao, Jun Fa; Tang, Min; Zhu, Yi Ming; Zhuang, Song Lin

2013-12-20

For traditional coherent effects, two separated identical point sources can be interfered with each other only when the optical path difference is integer number of wavelengths, leading to alternate dark and bright fringes for different optical path difference. For hundreds of years, such a perfect coherent condition seems insurmountable. However, in this paper, based on transformation optics, two separated in-phase identical point sources can induce perfect interference with each other without satisfying the traditional coherent condition. This shifting illusion media is realized by inductor-capacitor transmission line network. Theoretical analysis, numerical simulations and experimental results are performed to confirm such a kind of perfect coherent effect and it is found that the total radiation power of multiple elements system can be greatly enhanced. Our investigation may be applicable to National Ignition Facility (NIF), Inertial Confined Fusion (ICF) of China, LED lighting technology, terahertz communication, and so on.

Magneto-optical rotation in cavity QED with Zeeman coherence

NASA Astrophysics Data System (ADS)

Sun, Hui; Jia, Xiaohua; Fan, Shuangli; Zhang, Hongjun; Guo, Hong

2018-06-01

We investigate theoretically the magneto-optical rotation in cavity QED system with atomic Zeeman coherence, which is established via coherent population trapping. Owing to Zeeman coherence, the ultranarrow transmission spectrum less than 1 MHz with gain can be achieved with a flat-top Faraday rotation angle. By controlling the parameters appropriately, the input probe components within the flat-top regime rotate with almost the same angle, and transmit through the cavity perpendicularly to the other components outside the flat-top regime. The concepts discussed here provide an important tool for perfect ultranarrow Faraday optical filter and quantum information processing.

Full range line-field parallel swept source imaging utilizing digital refocusing

NASA Astrophysics Data System (ADS)

Fechtig, Daniel J.; Kumar, Abhishek; Drexler, Wolfgang; Leitgeb, Rainer A.

2015-12-01

We present geometric optics-based refocusing applied to a novel off-axis line-field parallel swept source imaging (LPSI) system. LPSI is an imaging modality based on line-field swept source optical coherence tomography, which permits 3-D imaging at acquisition speeds of up to 1 MHz. The digital refocusing algorithm applies a defocus-correcting phase term to the Fourier representation of complex-valued interferometric image data, which is based on the geometrical optics information of the LPSI system. We introduce the off-axis LPSI system configuration, the digital refocusing algorithm and demonstrate the effectiveness of our method for refocusing volumetric images of technical and biological samples. An increase of effective in-focus depth range from 255 μm to 4.7 mm is achieved. The recovery of the full in-focus depth range might be especially valuable for future high-speed and high-resolution diagnostic applications of LPSI in ophthalmology.

Coherent Optical Control of Electronic Excitations in Wide-Band-Gap Semiconductor Structures

DTIC Science & Technology

2015-05-01

ABSTRACT The main objective of this research is to study coherent quantum effects, such as Rabi oscillations in optical spectra of wide- band-gap...field corresponds to the rotation of the B vector about the pseudo field vector, Ω, with components determined by the effective Rabi frequency ( )e...to examine coherent quantum effects, such as Rabi oscillations and quantum entanglement in optical spectra of wide-band-gap materials, and to

Measuring finite-range phase coherence in an optical lattice using Talbot interferometry

PubMed Central

Santra, Bodhaditya; Baals, Christian; Labouvie, Ralf; Bhattacherjee, Aranya B.; Pelster, Axel; Ott, Herwig

2017-01-01

One of the important goals of present research is to control and manipulate coherence in a broad variety of systems, such as semiconductor spintronics, biological photosynthetic systems, superconducting qubits and complex atomic networks. Over the past decades, interferometry of atoms and molecules has proven to be a powerful tool to explore coherence. Here we demonstrate a near-field interferometer based on the Talbot effect, which allows us to measure finite-range phase coherence of ultracold atoms in an optical lattice. We apply this interferometer to study the build-up of phase coherence after a quantum quench of a Bose–Einstein condensate residing in a one-dimensional optical lattice. Our technique of measuring finite-range phase coherence is generic, easy to adopt and can be applied in practically all lattice experiments without further modifications. PMID:28580941

Physical-layer network coding in coherent optical OFDM systems.

PubMed

Guan, Xun; Chan, Chun-Kit

2015-04-20

We present the first experimental demonstration and characterization of the application of optical physical-layer network coding in coherent optical OFDM systems. It combines two optical OFDM frames to share the same link so as to enhance system throughput, while individual OFDM frames can be recovered with digital signal processing at the destined node.

Noise characterization of broadband fiber Cherenkov radiation as a visible-wavelength source for optical coherence tomography and two-photon fluorescence microscopy.

PubMed

Tu, Haohua; Zhao, Youbo; Liu, Yuan; Liu, Yuan-Zhi; Boppart, Stephen

2014-08-25

Optical sources in the visible region immediately adjacent to the near-infrared biological optical window are preferred in imaging techniques such as spectroscopic optical coherence tomography of endogenous absorptive molecules and two-photon fluorescence microscopy of intrinsic fluorophores. However, existing sources based on fiber supercontinuum generation are known to have high relative intensity noise and low spectral coherence, which may degrade imaging performance. Here we compare the optical noise and pulse compressibility of three high-power fiber Cherenkov radiation sources developed recently, and evaluate their potential to replace the existing supercontinuum sources in these imaging techniques.

Engineered diamond nanopillars as mobile probes for high sensitivity metrology in fluid

NASA Astrophysics Data System (ADS)

Andrich, P.; de Las Casas, C. F.; Heremans, F. J.; Awschalom, D. D.; Aleman, B. J.; Ohno, K.; Lee, J. C.; Hu, E. L.

2015-03-01

The nitrogen-vacancy (NV) center`s optical addressability and exceptional spin coherence properties at room temperature, along with diamond`s biocompatibility, has put this defect at the frontier of metrology applications in biological environments. To push the spatial resolution to the nanoscale, extensive research efforts focus on using NV centers embedded in nanodiamonds (NDs). However, this approach has been hindered by degraded spin coherence properties in NDs and the lack of a platform for spatial control of the nanoparticles in fluid. In this work, we combine the use of high quality diamond membranes with a top-down patterning technique to fabricate diamond nanoparticles with engineered and highly reproducible shape, size, and NV center density. We obtain NDs, easily releasable from the substrate into a water suspension, which contain single NV centers exhibiting consistently long spin coherence times (up to 700 μs). Additionally, we demonstrate highly stable, three-dimensional optical trapping of the nanoparticles within a microfluidic circuit. This level of control enables a bulk-like DC magnetic sensitivity and gives access to dynamical decoupling techniques on contactless, miniaturized diamond probes. This work was supported by DARPA, AFOSR, and the DIAMANT program.

Irregular oscillatory patterns in the early-time region of coherent phonon generation in silicon

NASA Astrophysics Data System (ADS)

Watanabe, Yohei; Hino, Ken-ichi; Hase, Muneaki; Maeshima, Nobuya

2017-09-01

Coherent phonon (CP) generation in an undoped Si crystal is theoretically investigated to shed light on unexplored quantum-mechanical effects in the early-time region immediately after the irradiation of ultrashort laser pulses. We examine time signals attributed to an induced charge density of an ionic core, placing the focus on the effects of the Rabi frequency Ω0 c v on the signals; this frequency corresponds to the peak electric-field of the pulse. It is found that at specific Ω0 c v's, where the energy of plasmon caused by photoexcited carriers coincides with the longitudinal-optical phonon energy, the energetically resonant interaction between these two modes leads to striking anticrossings, revealing irregular oscillations with anomalously enhanced amplitudes in the observed time signals. Also, the oscillatory pattern is subject to the Rabi flopping of the excited carrier density that is controlled by Ω0 c v. These findings show that the early-time region is enriched with quantum-mechanical effects inherent in the CP generation, though experimental signals are more or less masked by the so-called coherent artifact due to nonlinear optical effects.

Complementary use of optical coherence tomography and 5-aminolevulinic acid induced fluorescent spectroscopy for diagnosis of neoplastic processes in cervix and vulva

NASA Astrophysics Data System (ADS)

Sapozhnikova, Veronika V.; Shakhova, Natalia M.; Kamensky, Vladislav A.; Kuranov, Roman V.; Loshenov, Victor B.; Petrova, Svetlana A.

2003-07-01

A new approach to improving the diagnostic value of optical methods is suggested, which is based on a complementary investigation of different optical parameters of biotissues. The aim of this paper is comparative study of the feasibility of two optical methods - fluorescence spectroscopy and optical coherence tomography - for visualization of borders of neoplastic processes in the uterine cervix and vulva. Fluorescence spectroscopy is based on the detection of biochemical and optical coherence tomography on backscattering properties in norm and pathological changes of tissues. By means of these optical methods changes in biochemical and morphological properties of tissues were investigated. A parallel analysis of these two optical methods and histology from the center of tumors and their optical borders was made. Thirteen female patients with neoplastic changes in uterine cervix and vulva were enrolled in this study. The borders of the tumor determined by optical methods (fluorescence spectroscopy and optical coherence tomography) are coinciding with the biopsy proved ones. In addition, OCT and fluorescence borders of tumor in the uterine cervix and vulva exceeds colposcopically detectable borders, the averaging difference 2 mm. In future optical methods would considerably enhance diagnostic accuracy of conventional methods used in oncogynecology.

Quantum-coherent coupling of a mechanical oscillator to an optical cavity mode.

PubMed

Verhagen, E; Deléglise, S; Weis, S; Schliesser, A; Kippenberg, T J

2012-02-01

Optical laser fields have been widely used to achieve quantum control over the motional and internal degrees of freedom of atoms and ions, molecules and atomic gases. A route to controlling the quantum states of macroscopic mechanical oscillators in a similar fashion is to exploit the parametric coupling between optical and mechanical degrees of freedom through radiation pressure in suitably engineered optical cavities. If the optomechanical coupling is 'quantum coherent'--that is, if the coherent coupling rate exceeds both the optical and the mechanical decoherence rate--quantum states are transferred from the optical field to the mechanical oscillator and vice versa. This transfer allows control of the mechanical oscillator state using the wide range of available quantum optical techniques. So far, however, quantum-coherent coupling of micromechanical oscillators has only been achieved using microwave fields at millikelvin temperatures. Optical experiments have not attained this regime owing to the large mechanical decoherence rates and the difficulty of overcoming optical dissipation. Here we achieve quantum-coherent coupling between optical photons and a micromechanical oscillator. Simultaneously, coupling to the cold photon bath cools the mechanical oscillator to an average occupancy of 1.7 ± 0.1 motional quanta. Excitation with weak classical light pulses reveals the exchange of energy between the optical light field and the micromechanical oscillator in the time domain at the level of less than one quantum on average. This optomechanical system establishes an efficient quantum interface between mechanical oscillators and optical photons, which can provide decoherence-free transport of quantum states through optical fibres. Our results offer a route towards the use of mechanical oscillators as quantum transducers or in microwave-to-optical quantum links.

Reply to "Comment on `Dynamics of slow light and light storage in a Doppler-broadened electromagnetically-induced-transparency medium: A numerical approach' "

NASA Astrophysics Data System (ADS)

Gou, Shih-Chuan; Su, Shih-Wei; Yu, Ite A.

2017-10-01

A damping term in the theoretical model of our paper [Phys. Rev. A 83, 013827 (2011), 10.1103/PhysRevA.83.013827] was questioned by the author of the Comment. The author argued this damping term cannot exactly describe the spontaneous decay or quantum jump process and, thus, concluded that our results are prone to be incorrect. However, the physics of electromagnetically induced transparency (EIT) is mainly determined by the ground-state coherence and the optical coherence of the probe transition. We show here that the damping term in our paper described the relaxation process of optical coherence in the EIT system, but not the spontaneous decay process of the population. The case of spontaneous decay used in the argument of the Comment is not an issue in typical EIT studies, in which the probe field is weak and treated as the perturbation. Furthermore, the experimental data in the paper were taken under the condition of a weak probe field. Our theoretical model in the weak-probe condition actually deals with the two coherences of EIT physics, and is suitable for analysis of the data. We believe the results of the study, focusing on the dynamics of slow light and light storage in Doppler-broadened EIT media, are correct.

Retinal nerve fiber layer thickness measured with optical coherence tomography is related to visual function in glaucomatous eyes.

PubMed

El Beltagi, Tarek A; Bowd, Christopher; Boden, Catherine; Amini, Payam; Sample, Pamela A; Zangwill, Linda M; Weinreb, Robert N

2003-11-01

To determine the relationship between areas of glaucomatous retinal nerve fiber layer thinning identified by optical coherence tomography and areas of decreased visual field sensitivity identified by standard automated perimetry in glaucomatous eyes. Retrospective observational case series. Forty-three patients with glaucomatous optic neuropathy identified by optic disc stereo photographs and standard automated perimetry mean deviations >-8 dB were included. Participants were imaged with optical coherence tomography within 6 months of reliable standard automated perimetry testing. The location and number of optical coherence tomography clock hour retinal nerve fiber layer thickness measures outside normal limits were compared with the location and number of standard automated perimetry visual field zones outside normal limits. Further, the relationship between the deviation from normal optical coherence tomography-measured retinal nerve fiber layer thickness at each clock hour and the average pattern deviation in each visual field zone was examined by using linear regression (R(2)). The retinal nerve fiber layer areas most frequently outside normal limits were the inferior and inferior temporal regions. The least sensitive visual field zones were in the superior hemifield. Linear regression results (R(2)) showed that deviation from the normal retinal nerve fiber layer thickness at optical coherence tomography clock hour positions 6 o'clock, 7 o'clock, and 8 o'clock (inferior and inferior temporal) was best correlated with standard automated perimetry pattern deviation in visual field zones corresponding to the superior arcuate and nasal step regions (R(2) range, 0.34-0.57). These associations were much stronger than those between clock hour position 6 o'clock and the visual field zone corresponding to the inferior nasal step region (R(2) = 0.01). Localized retinal nerve fiber layer thinning, measured by optical coherence tomography, is topographically related to decreased localized standard automated perimetry sensitivity in glaucoma patients.

Multi-focus beam shaping of high power multimode lasers

NASA Astrophysics Data System (ADS)

Laskin, Alexander; Volpp, Joerg; Laskin, Vadim; Ostrun, Aleksei

2017-08-01

Beam shaping of powerful multimode fiber lasers, fiber-coupled solid-state and diode lasers is of great importance for improvements of industrial laser applications. Welding, cladding with millimetre scale working spots benefit from "inverseGauss" intensity profiles; performance of thick metal sheet cutting, deep penetration welding can be enhanced when distributing the laser energy along the optical axis as more efficient usage of laser energy, higher edge quality and reduction of the heat affected zone can be achieved. Building of beam shaping optics for multimode lasers encounters physical limitations due to the low beam spatial coherence of multimode fiber-coupled lasers resulting in big Beam Parameter Products (BPP) or M² values. The laser radiation emerging from a multimode fiber presents a mixture of wavefronts. The fiber end can be considered as a light source which optical properties are intermediate between a Lambertian source and a single mode laser beam. Imaging of the fiber end, using a collimator and a focusing objective, is a robust and widely used beam delivery approach. Beam shaping solutions are suggested in form of optics combining fiber end imaging and geometrical separation of focused spots either perpendicular to or along the optical axis. Thus, energy of high power lasers is distributed among multiple foci. In order to provide reliable operation with multi-kW lasers and avoid damages the optics are designed as refractive elements with smooth optical surfaces. The paper presents descriptions of multi-focus optics as well as examples of intensity profile measurements of beam caustics and application results.

Signal Coherence Recovery Using Acousto-Optic Fourier Transform Architectures

DTIC Science & Technology

1990-06-14

processing of data in ground- and space-based applications. We have implemented a prototype one-dimensional time-integrating acousto - optic (AO) Fourier...theory of optimum coherence recovery (CR) applicable in computation-limited environments. We have demonstrated direct acousto - optic implementation of CR

Optic flow detection is not influenced by visual-vestibular congruency.

PubMed

Holten, Vivian; MacNeilage, Paul R

2018-01-01

Optic flow patterns generated by self-motion relative to the stationary environment result in congruent visual-vestibular self-motion signals. Incongruent signals can arise due to object motion, vestibular dysfunction, or artificial stimulation, which are less common. Hence, we are predominantly exposed to congruent rather than incongruent visual-vestibular stimulation. If the brain takes advantage of this probabilistic association, we expect observers to be more sensitive to visual optic flow that is congruent with ongoing vestibular stimulation. We tested this expectation by measuring the motion coherence threshold, which is the percentage of signal versus noise dots, necessary to detect an optic flow pattern. Observers seated on a hexapod motion platform in front of a screen experienced two sequential intervals. One interval contained optic flow with a given motion coherence and the other contained noise dots only. Observers had to indicate which interval contained the optic flow pattern. The motion coherence threshold was measured for detection of laminar and radial optic flow during leftward/rightward and fore/aft linear self-motion, respectively. We observed no dependence of coherence thresholds on vestibular congruency for either radial or laminar optic flow. Prior studies using similar methods reported both decreases and increases in coherence thresholds in response to congruent vestibular stimulation; our results do not confirm either of these prior reports. While methodological differences may explain the diversity of results, another possibility is that motion coherence thresholds are mediated by neural populations that are either not modulated by vestibular stimulation or that are modulated in a manner that does not depend on congruency.

Artificial optical emissions in the thermosphere induced by powerful radio waves: A review

NASA Astrophysics Data System (ADS)

Kosch, M.; Senior, A.; Gustavsson, B.; Grach, S.; Pedersen, T.; Rietveld, M.

High-power high-frequency radio waves beamed into the ionosphere with O-mode polarization cause plasma turbulence which can accelerate electrons These electrons collide with the F-layer neutrals causing artificial optical emissions identical to natural aurora The brightest optical emissions are O 1D 630 nm with a threshold of 2 eV and O 1S 557 7 nm with a threshold of 4 2 eV The optical emissions give direct evidence of electron acceleration by plasma turbulence as well as their non-Maxwellian energy spectrum HF pumping of the ionosphere also causes electron temperature enhancements but these alone are not sufficient to explain the optical emissions EISCAT plasma-line measurements indicate that the enhanced electron temperatures are consistent with the bulk of the electrons having a Maxwellian energy spectrum Novel discoveries include 1 Very large electron temperature enhancements of several 1000 K which maximise along the magnetic field line direction 2 Ion temperature enhancements of a few 100 K 3 Large ion outflows exceeding 200 m s 4 The F-layer optical emission maximizes sharply near the magnetic zenith with clear evidence of self-focusing 5 The optical emission generally appears below the HF pump reflection altitude as well as the upper-hybrid resonance height 6 The optical emission and HF coherent radar backscatter generally minimize when pumping on the third or higher electron gyro-harmonic frequency suggesting upper-hybrid waves as the primary mechanism 7 The optical emissions and HF coherent backscatter are enhanced on the

MEMS-based non-rotatory circumferential scanning optical probe for endoscopic optical coherence tomography

NASA Astrophysics Data System (ADS)

Xu, Yingshun; Singh, Janak; Siang, Teo Hui; Ramakrishna, Kotlanka; Premchandran, C. S.; Sheng, Chen Wei; Kuan, Chuah Tong; Chen, Nanguang; Olivo, Malini C.; Sheppard, Colin J. R.

2007-07-01

In this paper, we present a non-rotatory circumferential scanning optical probe integrated with a MEMS scanner for in vivo endoscopic optical coherence tomography (OCT). OCT is an emerging optical imaging technique that allows high resolution cross-sectional imaging of tissue microstructure. To extend its usage to endoscopic applications, a miniaturized optical probe based on Microelectromechanical Systems (MEMS) fabrication techniques is currently desired. A 3D electrothermally actuated micromirror realized using micromachining single crystal silicon (SCS) process highlights its very large angular deflection, about 45 degree, with low driving voltage for safety consideration. The micromirror is integrated with a GRIN lens into a waterproof package which is compatible with requirements for minimally invasive endoscopic procedures. To implement circumferential scanning substantially for diagnosis on certain pathological conditions, such as Barret's esophagus, the micromirror is mounted on 90 degree to optical axis of GRIN lens. 4 Bimorph actuators that are connected to the mirror on one end via supporting beams and springs are selected in this micromirror design. When actuators of the micromirror are driven by 4 channels of sinusoidal waveforms with 90 degree phase differences, beam focused by a GRIN is redirected out of the endoscope by 45 degree tilting mirror plate and achieve circumferential scanning pattern. This novel driving method making full use of very large angular deflection capability of our micromirror is totally different from previously developed or developing micromotor-like rotatory MEMS device for circumferential scanning.

Evaluation of white-to-white distance and anterior chamber depth measurements using the IOL Master, slit-lamp adapted optical coherence tomography and digital photographs in phakic eyes.

PubMed

Wilczyński, Michał; Pośpiech-Zabierek, Aleksandra

2015-01-01

The accurate measurement of the anterior chamber internal diameter and depth is important in ophthalmic diagnosis and before some eye surgery procedures. The purpose of the study was to compare the white-to-white distance measurements performed using the IOL-Master and photography with internal anterior chamber diameter determined using slit lamp adapted optical coherence tomography in healthy eyes, and to compare anterior chamber depth measurements by IOL-Master and slit lamp adapted optical coherence tomography. The data were gathered prospectively from a non-randomized consecutive series of patients. The examined group consisted of 46 eyes of 39 patients. White-to-white was measured using IOL-Master and photographs of the eye were taken with a digital camera. Internal anterior chamber diameter was measured with slit-lamp adapted optical coherence tomography. Anterior chamber depth was measured using the IOL Master and slit-lamp adapted optical coherence tomography. Statistical analysis was performed using parametric tests. A Bland-Altman plot was drawn. White-to-white distance by the IOL Master was 11.8 +/- 0.40 mm, on photographs it was 11.29 +/- 0.58 mm and internal anterior chamber diameter by slit-lamp adapted optical coherence tomography was 11.34?0.54 mm. A significant difference was found between IOL-Master and slit-lamp adapted optical coherence tomography (p<0.01), as well as between IOL Master and digital photographs (p<0.01). There was no difference between SL-OCT and digital photographs (p>0.05). All measurements were correlated (Spearman p<0.001). Mean anterior chamber depth determined using the IOL-Master was 2.99 +/- 0.50 mm and by slit-lamp adapted optical coherence tomography was 2.56 +/- 0.46 mm. The difference was statistically significant (p<0.001). The correlation between the values was also statistically significant (Spearman, p<0.001). Automated measurements using IOL-Master yield constantly higher values than measurements based on direct eye visualization slit-lamp adapted optical coherence tomography and digital photographs. In order to obtain accurate measurements of the internal anterior chamber diameter and anterior chamber depth, a method involving direct visualization of intraocular structures should be used.

Capacity of optical communications over a lossy bosonic channel with a receiver employing the most general coherent electro-optic feedback control

NASA Astrophysics Data System (ADS)

Chung, Hye Won; Guha, Saikat; Zheng, Lizhong

2017-07-01

We study the problem of designing optical receivers to discriminate between multiple coherent states using coherent processing receivers—i.e., one that uses arbitrary coherent feedback control and quantum-noise-limited direct detection—which was shown by Dolinar to achieve the minimum error probability in discriminating any two coherent states. We first derive and reinterpret Dolinar's binary-hypothesis minimum-probability-of-error receiver as the one that optimizes the information efficiency at each time instant, based on recursive Bayesian updates within the receiver. Using this viewpoint, we propose a natural generalization of Dolinar's receiver design to discriminate M coherent states, each of which could now be a codeword, i.e., a sequence of N coherent states, each drawn from a modulation alphabet. We analyze the channel capacity of the pure-loss optical channel with a general coherent-processing receiver in the low-photon number regime and compare it with the capacity achievable with direct detection and the Holevo limit (achieving the latter would require a quantum joint-detection receiver). We show compelling evidence that despite the optimal performance of Dolinar's receiver for the binary coherent-state hypothesis test (either in error probability or mutual information), the asymptotic communication rate achievable by such a coherent-processing receiver is only as good as direct detection. This suggests that in the infinitely long codeword limit, all potential benefits of coherent processing at the receiver can be obtained by designing a good code and direct detection, with no feedback within the receiver.

TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis.

PubMed

Ploner, Stefan B; Moult, Eric M; Choi, WooJhon; Waheed, Nadia K; Lee, ByungKun; Novais, Eduardo A; Cole, Emily D; Potsaid, Benjamin; Husvogt, Lennart; Schottenhamml, Julia; Maier, Andreas; Rosenfeld, Philip J; Duker, Jay S; Hornegger, Joachim; Fujimoto, James G

2016-12-01

Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.

Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography.

PubMed

Grieve, Kate; Mouslim, Karima; Assayag, Osnath; Dalimier, Eugénie; Harms, Fabrice; Bruhat, Alexis; Boccara, Claude; Antoine, Martine

2016-04-01

Current techniques for the intraoperative analysis of sentinel lymph nodes during breast cancer surgery present drawbacks such as time and tissue consumption. Full-field optical coherence tomography is a novel noninvasive, high-resolution, fast imaging technique. This study investigated the use of full-field optical coherence tomography as an alternative technique for the intraoperative analysis of sentinel lymph nodes. Seventy-one axillary lymph nodes from 38 patients at Tenon Hospital were imaged minutes after excision with full-field optical coherence tomography in the pathology laboratory, before being handled for histological analysis. A pathologist performed a blind diagnosis (benign/malignant), based on the full-field optical coherence tomography images alone, which resulted in a sensitivity of 92% and a specificity of 83% (n = 65 samples). Regular feedback was given during the blind diagnosis, with thorough analysis of the images, such that features of normal and suspect nodes were identified in the images and compared with histology. A nonmedically trained imaging expert also performed a blind diagnosis aided by the reading criteria defined by the pathologist, which resulted in 85% sensitivity and 90% specificity (n = 71 samples). The number of false positives of the pathologist was reduced by 3 in a second blind reading a few months later. These results indicate that following adequate training, full-field optical coherence tomography can be an effective noninvasive diagnostic tool for extemporaneous sentinel node biopsy qualification. © The Author(s) 2015.

High frequency optical communications; Proceedings of the Meeting, Cambridge, MA, Sept. 23, 24, 1986

NASA Astrophysics Data System (ADS)

Ramer, O. Glenn; Sierak, Paul

Topics discussed in this volume include systems and applications, detectors, sources, and coherent communications. Papers are presented on RF fiber optic links for avionics applications, fiber optics and optoelectronics for radar and electronic warfare applications, symmetric coplanar electrodes for high-speed Ti:LiNbO3 devices, and surface wave electrooptic modulator. Attention is given to X-band RF fiber-optic links, fiber-optic links for microwave signal transmission, GaAs monolithic receiver and laser driver for GHz transmission rates, and monolithically integrable high-speed photodetectors. Additional papers are on irregular and chaotic behavior of semiconductor lasers under modulation, high-frequency laser package for microwave optical communications, receiver modeling for coherent light wave communications, and polarization sensors and controllers for coherent optical communication systems.

Coherent control of optical polarization effects in metamaterials

PubMed Central

Mousavi, Seyedmohammad A.; Plum, Eric; Shi, Jinhui; Zheludev, Nikolay I.

2015-01-01

Processing of photonic information usually relies on electronics. Aiming to avoid the conversion between photonic and electronic signals, modulation of light with light based on optical nonlinearity has become a major research field and coherent optical effects on the nanoscale are emerging as new means of handling and distributing signals. Here we demonstrate that in slabs of linear material of sub-wavelength thickness optical manifestations of birefringence and optical activity (linear and circular birefringence and dichroism) can be controlled by a wave coherent with the wave probing the polarization effect. We demonstrate this in proof-of-principle experiments for chiral and anisotropic microwave metamaterials, where we show that the large parameter space of polarization characteristics may be accessed at will by coherent control. Such control can be exerted at arbitrarily low intensities, thus arguably allowing for fast handling of electromagnetic signals without facing thermal management and energy challenges. PMID:25755071

Coherent optical processing using noncoherent light after source masking.

PubMed

Boopathi, V; Vasu, R M

1992-01-10

Coherent optical processing starting with spatially noncoherent illumination is described. Good spatial coherence is introduced in the far field by modulating a noncoherent source when masks with sharp autocorrelation are used. The far-field mutual coherence function of light is measured and it is seen that, for the masks and the source size used here, we get a fairly large area over which the mutual coherence function is high and flat. We demonstrate traditional coherent processing operations such as Fourier transformation and image deblurring when coherent light that is produced in the above fashion is used. A coherence-redundancy merit function is defined for this type of processing system. It is experimentally demonstrated that the processing system introduced here has superior blemish tolerance compared with a traditional processor that uses coherent illumination.

Retinal Evaluation Using Optical Coherence Tomography (OCT) During Deep Space Gateway Missions

NASA Astrophysics Data System (ADS)

Stenger, M. B.; Laurie, S. S.; Macias, B. R.; Barr, Y. R.

2018-02-01

Optical Coherence Tomography (OCT) imaging will be conducted before, during, and after Deep Space Gateway missions to evaluate changes in the retina and, in particular, the optic nerve head and surrounding structures. Additional parameters will be collected before and after flight.

Phase noise reduction by optical phase-locked loop for a coherent bichromatic laser based on the injection-locking technique.

PubMed

Wu, C F; Yan, X S; Huang, J Q; Zhang, J W; Wang, L J

2018-01-01

We present a coherent bichromatic laser system with low phase noise. An optical injection process is used to generate coherent laser beams with a frequency difference of 9.192 631 77 GHz using an electro-optical modulator. An optical phase-locked loop is then applied to reduce the phase noise. The phase noise of the beat note is -41, -81, -98, -83, and -95 dBrad 2 /Hz at the offset frequencies of 1 Hz, 100 Hz, 1 kHz, 10 kHz, and 1 MHz, respectively. Compared to a system that uses optical injection alone, the phase noise is reduced by up to 20-30 dB in the low-frequency range, and the intermodulation effect on the continuous atomic clock is reduced by an order of magnitude. This configuration can adjust the intensities and polarizations of the laser beams independently and reduce the phase noise caused by environmental disturbances and optical injection, which may be useful for application to atomic coherence experiments.

Phase noise reduction by optical phase-locked loop for a coherent bichromatic laser based on the injection-locking technique

NASA Astrophysics Data System (ADS)

Wu, C. F.; Yan, X. S.; Huang, J. Q.; Zhang, J. W.; Wang, L. J.

2018-01-01

We present a coherent bichromatic laser system with low phase noise. An optical injection process is used to generate coherent laser beams with a frequency difference of 9.192 631 77 GHz using an electro-optical modulator. An optical phase-locked loop is then applied to reduce the phase noise. The phase noise of the beat note is -41, -81, -98, -83, and -95 dBrad2/Hz at the offset frequencies of 1 Hz, 100 Hz, 1 kHz, 10 kHz, and 1 MHz, respectively. Compared to a system that uses optical injection alone, the phase noise is reduced by up to 20-30 dB in the low-frequency range, and the intermodulation effect on the continuous atomic clock is reduced by an order of magnitude. This configuration can adjust the intensities and polarizations of the laser beams independently and reduce the phase noise caused by environmental disturbances and optical injection, which may be useful for application to atomic coherence experiments.

Real-time optical coherence tomography observation of retinal tissue damage during laser photocoagulation therapy on ex-vivo porcine samples

NASA Astrophysics Data System (ADS)

Steiner, P.; Považay, B.; Stoller, M.; Morgenthaler, P.; Inniger, D.; Arnold, P.; Sznitman, R.; Meier, Ch.

2015-07-01

Retinal laser photocoagulation represents a widely used treatment for retinal pathologies such as diabetic chorioretinopathy or diabetic edema. For effective treatment, an appropriate choice of the treatment energy dose is crucial to prevent excessive tissue damage caused by over-irradiation of the retina. In this manuscript we investigate simultaneous and time-resolved optical coherence tomography for its applicability to provide feedback to the ophthalmologist about the introduced retinal damage during laser photocoagulation. Time-resolved and volumetric optical coherence tomography data of 96 lesions on ex-vivo porcine samples, set with a 577 nm laser prototype and irradiance of between 300 and 8800 W=cm2 were analyzed. Time-resolved scans were compared to volumetric scans of the lesion and correlated with ophthalmoscopic visibility. Lastly, image parameters extracted from optical coherence tomography Mscans, suitable for lesion classification were identified. Results presented in this work support the hypothesis that simultaneous optical coherence tomography provides valuable information about the extent of retinal tissue damage and may be used to guide retinal laser photocoagulation in the future.

Nonlocal Electron Coherence in MoS2 Flakes Correlated through Spatial Self Phase Modulation

NASA Astrophysics Data System (ADS)

Wu, Yanling; Wu, Qiong; Sun, Fei; Tian, Yichao; Zuo, Xu; Meng, Sheng; Zhao, Jimin

2015-03-01

Electron coherence among different flake domains of MoS2 has been generated using ultrafast or continuous wave laser beams. Such electron coherence generates characteristic far-field diffraction patterns through a purely coherent nonlinear optical effect--spatial self-phase modulation (SSPM). A wind-chime model is developed to describe the establishment of the electron coherence through correlating the photo-excited electrons among different flakes using coherent light. Owing to its finite gap band structure, we find different mechanisms, including two-photon processes, might be responsible for the SSPM in MoS2 [with a large nonlinear dielectric susceptibility χ (3) = 1.6 × 10-9 e.s.u. (SI: 2.23 × 10-17 m2/V2) per layer]. Finally, we realized all optical switching based on SSPM, demonstrating that the electron coherence generation we report here is a ubiquitous property of layered quantum materials, by which novel optical applications are accessible. National Natural Science Foundation of China (11274372).

Coherent and partially coherent dark hollow beams with rectangular symmetry and paraxial propagation properties

NASA Astrophysics Data System (ADS)

Cai, Yangjian; Zhang, Lei

2006-07-01

A theoretical model is proposed to describe coherent dark hollow beams (DHBs) with rectangular symmetry. The electric field of a coherent rectangular DHB is expressed as a superposition of a series of the electric field of a finite series of fundamental Gaussian beams. Analytical propagation formulas for a coherent rectangular DHB passing through paraxial optical systems are derived in a tensor form. Furthermore, for the more general case, we propose a theoretical model to describe a partially coherent rectangular DHB. Analytical propagation formulas for a partially coherent rectangular DHB passing through paraxial optical systems are derived. The beam propagation factor (M2 factor) for both coherent and partially coherent rectangular DHBs are studied. Numerical examples are given by using the derived formulas. Our models and method provide an effective way to describe and treat the propagation of coherent and partially coherent rectangular DHBs.

Femtosecond Timekeeping: Slip-Free Clockwork for Optical Timescales

NASA Astrophysics Data System (ADS)

Herman, D.; Droste, S.; Baumann, E.; Roslund, J.; Churin, D.; Cingoz, A.; Deschênes, J.-D.; Khader, I. H.; Swann, W. C.; Nelson, C.; Newbury, N. R.; Coddington, I.

2018-04-01

The generation of true optical time standards will require the conversion of the highly stable optical-frequency output of an optical atomic clock to a high-fidelity time output. We demonstrate a comb-based clockwork that phase-coherently integrates ˜7 ×1020 optical cycles of an input optical frequency to create a coherent time output. We verify the underlying stability of the optical timing system by comparing two comb-based clockworks with a common input optical frequency and show <20 fs total time drift over the 37-day measurement period. Both clockworks also generate traditional timing signals including an optical pulse per second and a 10-MHz rf reference. The optical pulse-per-second time outputs remain synchronized to 240 attoseconds (240 as) at 1000 s. The phase-coherent 10-MHz rf outputs are stable to near a part in 1019 . Fault-free timekeeping from an optical clock to femtosecond level over months is an important step in replacing the current microwave time standard by an optical standard.

Nonexponential Decoherence and Subdiffusion in Atom-Optics Kicked Rotor.

PubMed

Sarkar, Sumit; Paul, Sanku; Vishwakarma, Chetan; Kumar, Sunil; Verma, Gunjan; Sainath, M; Rapol, Umakant D; Santhanam, M S

2017-04-28

Quantum systems lose coherence upon interaction with the environment and tend towards classical states. Quantum coherence is known to exponentially decay in time so that macroscopic quantum superpositions are generally unsustainable. In this work, slower than exponential decay of coherences is experimentally realized in an atom-optics kicked rotor system subjected to nonstationary Lévy noise in the applied kick sequence. The slower coherence decay manifests in the form of quantum subdiffusion that can be controlled through the Lévy exponent. The experimental results are in good agreement with the analytical estimates and numerical simulations for the mean energy growth and momentum profiles of an atom-optics kicked rotor.

Optical Coherence Tomography

PubMed Central

Huang, David; Swanson, Eric A.; Lin, Charles P.; Schuman, Joel S.; Stinson, William G.; Chang, Warren; Hee, Michael R.; Flotte, Thomas; Gregory, Kenton; Puliafito, Carmen A.; Fujimoto, James G.

2015-01-01

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as ~10−10 of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively. PMID:1957169

Coherent Perfect Rotation

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Dawson, Nathan; Andrews, James

2012-04-01

Two classes of conservative, linear, optical rotary effects (optical activity and Faraday rotation) are distinguished by their behavior under time reversal. In analogy with coherent perfect absorption, where counterpropagating light fields are controllably converted into other degrees of freedom, we show that in a linear-conservative medium only time-odd (Faraday) rotation is capable of coherent perfect rotation, by which we mean the complete transfer of counterpropagating coherent light fields into their orthogonal polarization. This highlights the necessity of time reversal odd processes (not just absorption) and coherence in perfect mode conversion and may inform device design.

Coherence properties and quantum state transportation in an optical conveyor belt.

PubMed

Kuhr, S; Alt, W; Schrader, D; Dotsenko, I; Miroshnychenko, Y; Rosenfeld, W; Khudaverdyan, M; Gomer, V; Rauschenbeutel, A; Meschede, D

2003-11-21

We have prepared and detected quantum coherences of trapped cesium atoms with long dephasing times. Controlled transport by an "optical conveyor belt" over macroscopic distances preserves the atomic coherence with slight reduction of coherence time. The limiting dephasing effects are experimentally identified, and we present an analytical model of the reversible and irreversible dephasing mechanisms. Our experimental methods are applicable at the single-atom level. Coherent quantum bit operations along with quantum state transport open the route towards a "quantum shift register" of individual neutral atoms.

Geometrical and wave optics of paraxial beams.

PubMed

Meron, M; Viccaro, P J; Lin, B

1999-06-01

Most calculational techniques used to evaluate beam propagation are geared towards either fully coherent or fully incoherent beams. The intermediate partial-coherence regime, while in principle known for a long time, has received comparably little attention so far. The resulting shortage of adequate calculational techniques is currently being felt in the realm of x-ray optics where, with the advent of third generation synchrotron light sources, partially coherent beams become increasingly common. The purpose of this paper is to present a calculational approach which, utilizing a "variance matrix" representation of paraxial beams, allows for a straightforward evaluation of wave propagation through an optical system. Being capable of dealing with an arbitrary degree of coherence, this approach covers the whole range from wave to ray optics, in a seamless fashion.

Physics and applications of atmospheric nonlinear optics and filamentation.

PubMed

Kasparian, Jérôme; Wolf, Jean-Pierre

2008-01-07

We review the properties and applications of ultrashort laser pulses in the atmosphere, with a particular focus on filamentation. Filamentation is a non-linear propagation regime specific of ultrashort and ultraintense laser pulses in the atmosphere. Typical applications include remote sensing of atmospheric gases and aerosols, lightning control, laser-induced spectroscopy, coherent anti-stokes Raman scattering, and the generation of sub-THz radiation.

Ultradispersive adaptive prism based on a coherently prepared atomic medium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sautenkov, Vladimir A.; P. N. Lebedev Institute of Physics, Moscow 119991; Li Hebin

2010-06-15

We have experimentally demonstrated an ultra-dispersive optical prism made from a coherently driven Rb atomic vapor. The prism possesses spectral angular dispersion that is 6 orders of magnitude higher than that of a prism made of optical glass; such angular dispersion allows one to spatially resolve light beams with different frequencies separated by a few kilohertz. The prism operates near the resonant frequency of atomic vapor and its dispersion is optically controlled by a coherent driving field.

Spin and Optical Characterization of Defects in Group IV Semiconductors for Quantum Memory Applications

NASA Astrophysics Data System (ADS)

Rose, Brendon Charles

This thesis is focused on the characterization of highly coherent defects in both silicon and diamond, particularly in the context of quantum memory applications. The results are organized into three parts based on the spin system: phosphorus donor electron spins in silicon, negatively charged nitrogen vacancy color centers in diamond (NV-), and neutrally charged silicon vacancy color centers in diamond (SiV0). The first part on phosphorus donor electron spins presents the first realization of strong coupling with spins in silicon. To achieve this, the silicon crystal was made highly pure and highly isotopically enriched so that the ensemble dephasing time, T2*, was long (10 micros). Additionally, the use of a 3D resonator aided in realizing uniform coupling, allowing for high fidelity spin ensemble manipulation. These two properties have eluded past implementations of strongly coupled spin ensembles and have been the limiting factor in storing and retrieving quantum information. Second, we characterize the spin properties of the NV- color center in diamond in a large magnetic field. We observe that the electron spin echo envelope modulation originating from the central 14N nuclear spin is much stronger at large fields and that the optically induced spin polarization exhibits a strong orientation dependence that cannot be explained by the existing model for the NV- optical cycle, we develop a modification of the existing model that reproduces the data in a large magnetic field. In the third part we perform characterization and stabilization of a new color center in diamond, SiV0, and find that it has attractive, highly sought-after properties for use as a quantum memory in a quantum repeater scheme. We demonstrate a new approach to the rational design of new color centers by engineering the Fermi level of the host material. The spin properties were characterized in electron spin resonance, revealing long spin relaxation and spin coherence times at cryogenic temperature. Additionally, we observe that the optical emission is highly coherent, predominately into a narrow zero phonon line that is stable in frequency. The combination of coherent optical and spin degrees of freedom has eluded all previous solid state defects.

Micro-optical design of a three-dimensional microlens scanner for vertically integrated micro-opto-electro-mechanical systems.

PubMed

Baranski, Maciej; Bargiel, Sylwester; Passilly, Nicolas; Gorecki, Christophe; Jia, Chenping; Frömel, Jörg; Wiemer, Maik

2015-08-01

This paper presents the optical design of a miniature 3D scanning system, which is fully compatible with the vertical integration technology of micro-opto-electro-mechanical systems (MOEMS). The constraints related to this integration strategy are considered, resulting in a simple three-element micro-optical setup based on an afocal scanning microlens doublet and a focusing microlens, which is tolerant to axial position inaccuracy. The 3D scanning is achieved by axial and lateral displacement of microlenses of the scanning doublet, realized by micro-electro-mechanical systems microactuators (the transmission scanning approach). Optical scanning performance of the system is determined analytically by use of the extended ray transfer matrix method, leading to two different optical configurations, relying either on a ball lens or plano-convex microlenses. The presented system is aimed to be a core component of miniature MOEMS-based optical devices, which require a 3D optical scanning function, e.g., miniature imaging systems (confocal or optical coherence microscopes) or optical tweezers.

Nonuniform Liouville transformers for quasi-homogeneous optical fields. Final technical report, September 25, 1989--January 22, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jannson, T.

1993-03-01

During the last two decades, there have been dramatic improvements in the development of optical sources. Examples of this development range from semiconductor laser diodes to free electron beam lasers and synchrotron radiation. Before these developments, standards for the measurement of basic optical parameters (quantities) were less demanding. Now, however, there is a fundamental need for new, reliable methods for providing fast quantitative results for a very broad variety of optical systems and sources. This is particularly true for partially coherent optical beams, since all optical sources are either fully or partially spatially coherent (including Lambertian sources). Until now, theremore » has been no satisfactory solution to this problem. During the last two decades, however, the foundations of physical radiometry have been developed by Walther, Wolf and co-workers. By integrating physical optics, statistical optics and conventional radiometry, this body of work provides necessary tools for the evaluation of radiometric quantities for partially coherent optical beams propagating through optical systems. In this program, Physical Optics Corporation (POC) demonstrated the viability of such a radiometric approach for the specific case of generalized energy concentrators called Liouville transformers. We believe that this radiometric approach is necessary to fully characterize any type of optical system since it takes into account the partial coherence of radiation. 90 refs., 57 figs., 4 tabs.« less

Elimination of coherent noise in a coherent light imaging system

NASA Technical Reports Server (NTRS)

Grebowsky, G. J.; Hermann, R. L.; Paull, H. B.; Shulman, A. R.

1970-01-01

Optical imaging systems using coherent light introduce objectionable noise into the output image plane. Dust and bubbles on and in lenses cause most of the noise in the output image. This noise usually appears as bull's-eye diffraction patterns in the image. By rotating the lens about the optical axis these diffraction patterns can be essentially eliminated. The technique does not destroy the spatial coherence of the light and permits spatial filtering of the input plane.

Investigation of the benefit of adaptive optics optical coherence tomography angiography for the human retina (Conference Presentation)

NASA Astrophysics Data System (ADS)

Salas, Matthias; Augustin, Marco; Ginner, Laurin; Kumar, Abhishek; Baumann, Bernhard; Leitgeb, Rainer A.; Drexler, Wolfgang; Prager, Sonja; Hafner, Julia; Schmidt-Erfurth, Ursula; Pircher, Michael

2017-02-01

In this work we investigate the benefits of using optical coherence tomography angiography (OCTA) in combination with adaptive optics (AO) technology. It has been demonstrated that the contrast of vessels and small capillaries can be greatly enhanced by the use of OCTA. Moreover, small capillaries that are below the transverse resolution of the ophthalmic instrument can be detected. This opens unique opportunities for diagnosing retinal diseases. However, there are some limitations of this technology such as shadowing artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density can be misleading. To overcome these limitations we applied the OCT angiography technique to images recorded with AO-OCT. Due to the higher collection efficiency of AO-OCT in comparison with standard OCT an increased intensity contrast of vasculature can be seen. Using AO-OCTA the contrast of the vasculature to the surrounding static tissue is further increased. The improved transverse resolution and the reduced depth of focus of the AO-OCT greatly reduce shadowing artifacts allowing for a correct differentiation and segmentation of different vascular layers of the inner retina. The method is investigated in healthy volunteers and in patients with diabetic retinopathy.

Design concepts for an on-board coherent optical image processor

NASA Technical Reports Server (NTRS)

Husain-Abidi, A. S.

1972-01-01

On-board spacecraft image data processing systems for transmitting processed data rather than raw data are discussed. A brief history of the development of the optical data processing techniques is presented along with the conceptual design of a coherent optical system with a noncoherent image input.

Intrinsic coherence time of trions in monolayer MoSe2 measured via two-dimensional coherent spectroscopy

NASA Astrophysics Data System (ADS)

Titze, Michael; Li, Bo; Zhang, Xiang; Ajayan, Pulickel M.; Li, Hebin

2018-05-01

Quantum coherence and its dynamics in monolayer transition metal dichalcogenides (TMDs) are essential information to fully control valley pseudospin for valleytronics applications. Experimental understanding of coherence dephasing dynamics has been limited for excitons and largely unexplored for trions in monolayer TMDs. Here we use optical two-dimensional coherent spectroscopy to measure the trion coherence dephasing time in monolayer MoSe2 by analyzing the homogeneous linewidth. An intrinsic coherence time of 182 fs is extrapolated from the excitation density and temperature dependence measurement. The results show that trion-trion and trion-phonon interactions strongly affect the coherence dephasing time, while the intrinsic coherence time at zero excitation and zero temperature is primarily limited by the pure dephasing due to defect states. Our experiment also confirms optical two-dimensional coherent spectroscopy as a reliable technique for studying valley quantum dynamics in two-dimensional layered materials.

Spectral optical coherence tomography for ophthalmologic applications

NASA Astrophysics Data System (ADS)

Targowski, Piotr; Bajraszewski, Tomasz; Gorczyńska, Iwona; Szkulmowska, Anna; Szkulmowski, Maciej; Wojtkowski, Maciej; Kowalczyk, Andrzej; Kaluzny, Jakub J.; Kaluzny, Bartłomiej J.

2006-09-01

The overview of the Spectral Optical Coherence Tomography an alternative method to more popular Time domain modality is given. Examples from medical practice utilizing high resolution, ultra fast SOCT device are presented.

Coherent beam control through inhomogeneous media in multi-photon microscopy

NASA Astrophysics Data System (ADS)

Paudel, Hari Prasad

Multi-photon fluorescence microscopy has become a primary tool for high-resolution deep tissue imaging because of its sensitivity to ballistic excitation photons in comparison to scattered excitation photons. The imaging depth of multi-photon microscopes in tissue imaging is limited primarily by background fluorescence that is generated by scattered light due to the random fluctuations in refractive index inside the media, and by reduced intensity in the ballistic focal volume due to aberrations within the tissue and at its interface. We built two multi-photon adaptive optics (AO) correction systems, one for combating scattering and aberration problems, and another for compensating interface aberrations. For scattering correction a MEMS segmented deformable mirror (SDM) was inserted at a plane conjugate to the objective back-pupil plane. The SDM can pre-compensate for light scattering by coherent combination of the scattered light to make an apparent focus even at a depths where negligible ballistic light remains (i.e. ballistic limit). This problem was approached by investigating the spatial and temporal focusing characteristics of a broad-band light source through strongly scattering media. A new model was developed for coherent focus enhancement through or inside the strongly media based on the initial speckle contrast. A layer of fluorescent beads under a mouse skull was imaged using an iterative coherent beam control method in the prototype two-photon microscope to demonstrate the technique. We also adapted an AO correction system to an existing in three-photon microscope in a collaborator lab at Cornell University. In the second AO correction approach a continuous deformable mirror (CDM) is placed at a plane conjugate to the plane of an interface aberration. We demonstrated that this "Conjugate AO" technique yields a large field-of-view (FOV) advantage in comparison to Pupil AO. Further, we showed that the extended FOV in conjugate AO is maintained over a relatively large axial misalignment of the conjugate planes of the CDM and the aberrating interface. This dissertation advances the field of microscopy by providing new models and techniques for imaging deeply within strongly scattering tissue, and by describing new adaptive optics approaches to extending imaging FOV due to sample aberrations.

The laboratory demonstration and signal processing of the inverse synthetic aperture imaging ladar

NASA Astrophysics Data System (ADS)

Gao, Si; Zhang, ZengHui; Xu, XianWen; Yu, WenXian

2017-10-01

This paper presents a coherent inverse synthetic-aperture imaging ladar(ISAL)system to obtain high resolution images. A balanced coherent optics system in laboratory is built with binary phase coded modulation transmit waveform which is different from conventional chirp. A whole digital signal processing solution is proposed including both quality phase gradient autofocus(QPGA) algorithm and cubic phase function(CPF) algorithm. Some high-resolution well-focused ISAL images of retro-reflecting targets are shown to validate the concepts. It is shown that high resolution images can be achieved and the influences from vibrations of platform involving targets and radar can be automatically compensated by the distinctive laboratory system and digital signal process.

Characteristics of light reflected from a dense ionization wave with a tunable velocity.

PubMed

Zhidkov, A; Esirkepov, T; Fujii, T; Nemoto, K; Koga, J; Bulanov, S V

2009-11-20

An optically dense ionization wave (IW) produced by two femtosecond (approximately 10/30 fs) laser pulses focused cylindrically and crossing each other may become an efficient coherent x-ray converter in accordance with the Semenova-Lampe theory. The resulting velocity of a quasiplane IW in the vicinity of pulse intersection changes with the angle between the pulses from the group velocity of ionizing pulses to infinity allowing a tuning of the wavelength of x rays and their bunching. The x-ray spectra after scattering of a lower frequency and long coherent light pulse change from the monochromatic to high order harmoniclike with the duration of the ionizing pulses.

Non-Hermitian optics in atomic systems

NASA Astrophysics Data System (ADS)

Zhang, Zhaoyang; Ma, Danmeng; Sheng, Jiteng; Zhang, Yiqi; Zhang, Yanpeng; Xiao, Min

2018-04-01

A wide class of non-Hermitian Hamiltonians can possess entirely real eigenvalues when they have parity-time (PT) symmetric potentials. Recently, this family of non-Hermitian systems has attracted considerable attention in diverse areas of physics due to their extraordinary properties, especially in optical systems based on solid-state materials, such as coupled gain-loss waveguides and microcavities. Considering the desired refractive index can be effectively manipulated through atomic coherence, it is important to realize such non-Hermitian optical potentials and further investigate their distinct properties in atomic systems. In this paper, we review the recent theoretical and experimental progress of non-Hermitian optics with coherently prepared multi-level atomic configurations. The realizations of (anti-) PT symmetry with different schemes have extensively demonstrated the special optical properties of non-Hermitian optical systems with atomic coherence.

The Development, Commercialization, and Impact of Optical Coherence Tomography.

PubMed

Fujimoto, James; Swanson, Eric

2016-07-01

This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function - diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an "ecosystem" consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact - all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest.

Multiplex coherent raman spectroscopy detector and method

NASA Technical Reports Server (NTRS)

Joyner, Candace C. (Inventor); Patrick, Sheena T. (Inventor); Chen, Peter (Inventor); Guyer, Dean R. (Inventor)

2004-01-01

A multiplex coherent Raman spectrometer (10) and spectroscopy method rapidly detects and identifies individual components of a chemical mixture separated by a separation technique, such as gas chromatography. The spectrometer (10) and method accurately identify a variety of compounds because they produce the entire gas phase vibrational Raman spectrum of the unknown gas. This is accomplished by tilting a Raman cell (20) to produce a high-intensity, backward-stimulated, coherent Raman beam of 683 nm, which drives a degenerate optical parametric oscillator (28) to produce a broadband beam of 1100-1700 nm covering a range of more than 3000 wavenumber. This broadband beam is combined with a narrowband beam of 532 nm having a bandwidth of 0.003 wavenumbers and focused into a heated windowless cell (38) that receives gases separated by a gas chromatograph (40). The Raman radiation scattered from these gases is filtered and sent to a monochromator (50) with multichannel detection.

Multiplex coherent raman spectroscopy detector and method

DOEpatents

Chen, Peter; Joyner, Candace C.; Patrick, Sheena T.; Guyer, Dean R.

2004-06-08

A multiplex coherent Raman spectrometer (10) and spectroscopy method rapidly detects and identifies individual components of a chemical mixture separated by a separation technique, such as gas chromatography. The spectrometer (10) and method accurately identify a variety of compounds because they produce the entire gas phase vibrational Raman spectrum of the unknown gas. This is accomplished by tilting a Raman cell (20) to produce a high-intensity, backward-stimulated, coherent Raman beam of 683 nm, which drives a degenerate optical parametric oscillator (28) to produce a broadband beam of 1100-1700 nm covering a range of more than 3000 wavenumber. This broadband beam is combined with a narrowband beam of 532 nm having a bandwidth of 0.003 wavenumbers and focused into a heated windowless cell (38) that receives gases separated by a gas chromatograph (40). The Raman radiation scattered from these gases is filtered and sent to a monochromator (50) with multichannel detection.

Simple and versatile long range swept source for optical coherence tomography applications

NASA Astrophysics Data System (ADS)

Bräuer, Bastian; Lippok, Norman; Murdoch, Stuart G.; Vanholsbeeck, Frédérique

2015-12-01

We present a versatile long coherence length swept-source laser design for optical coherence tomography applications. This design consists of a polygonal spinning mirror and an optical gain chip in a modified Littman-Metcalf cavity. A narrowband intra-cavity filter is implemented through multiple passes off a diffraction grating set at grazing incidence. The key advantage of this design is that it can be readily adapted to any wavelength regions for which broadband gain chips are available. We demonstrate this by implementing sources at 1650 nm, 1550 nm, 1310 nm and 1050 nm. In particular, we present a 1310 nm swept source laser with 24 mm coherence length, 95 nm optical bandwidth, 2 kHz maximum sweep frequency and 7.5 mW average output power. These parameters make it a suitable source for the imaging of biological samples.

On the performance of joint iterative detection and decoding in coherent optical channels with laser frequency fluctuations

NASA Astrophysics Data System (ADS)

Castrillón, Mario A.; Morero, Damián A.; Agazzi, Oscar E.; Hueda, Mario R.

2015-08-01

The joint iterative detection and decoding (JIDD) technique has been proposed by Barbieri et al. (2007) with the objective of compensating the time-varying phase noise and constant frequency offset experienced in satellite communication systems. The application of JIDD to optical coherent receivers in the presence of laser frequency fluctuations has not been reported in prior literature. Laser frequency fluctuations are caused by mechanical vibrations, power supply noise, and other mechanisms. They significantly degrade the performance of the carrier phase estimator in high-speed intradyne coherent optical receivers. This work investigates the performance of the JIDD algorithm in multi-gigabit optical coherent receivers. We present simulation results of bit error rate (BER) for non-differential polarization division multiplexing (PDM)-16QAM modulation in a 200 Gb/s coherent optical system that includes an LDPC code with 20% overhead and net coding gain of 11.3 dB at BER = 10-15. Our study shows that JIDD with a pilot rate ⩽ 5 % compensates for both laser phase noise and laser frequency fluctuation. Furthermore, since JIDD is used with non-differential modulation formats, we find that gains in excess of 1 dB can be achieved over existing solutions based on an explicit carrier phase estimator with differential modulation. The impact of the fiber nonlinearities in dense wavelength division multiplexing (DWDM) systems is also investigated. Our results demonstrate that JIDD is an excellent candidate for application in next generation high-speed optical coherent receivers.

Single laser beam of spatial coherence from an array of GaAs lasers - Free-running mode

NASA Technical Reports Server (NTRS)

Philipp-Rutz, E. M.

1975-01-01

Spatially coherent radiation from a monolithic array of three GaAs lasers in a free-running mode is reported. The lasers, with their mirror faces antireflection coated, are operated in an external optical cavity built of spherical lenses and plane mirrors. The spatially coherent-beam formation makes use of the Fourier-transformation property of the internal lenses. Transverse mode control is accomplished by a spatial filter. The optical cavity is similar to that used for the phase-controlled mode of spatially coherent-beam formation; only the spatial filters are different. In the far field (when restored by an external lens), the intensities of the lasers in the array are concentrated in a single laser beam of spatial coherence, without any grating lobes. The far-field distribution of the laser array in the free-running mode differs significantly from the interference pattern of the phase-controlled mode. The modulation characteristics of the optical waveforms of the two modes are also quite different because modulation is related to the interaction of the spatial filter with the longitudinal modes of the laser array within the optical cavity. The modulation of the optical waveform of the free-running mode is nonperiodic, confirming that the fluctuations of the optical fields of the lasers are random.

Mechanical characterization of the mouse diaphragm with optical coherence elastography reveals fibrosis-related change of direction-dependent muscle tissue stiffness

NASA Astrophysics Data System (ADS)

Wang, Shang; Loehr, James A.; Larina, Irina V.; Rodney, George G.; Larin, Kirill V.

2016-03-01

The diaphragm, composed of skeletal muscle, plays an important role in respiration through its dynamic contraction. Genetic and molecular studies of the biomechanics of mouse diaphragm can provide great insights into an improved understanding and potential treatment of the disorders that lead to diaphragm dysfunction (i.e. muscular dystrophy). However, due to the small tissue size, mechanical assessment of mouse diaphragm tissue under its proper physiological conditions has been challenging. Here, we present the application of noncontact optical coherence elastography (OCE) for quantitative elastic characterization of ex vivo mouse diaphragm. Phase-sensitive optical coherence tomography was combined with a focused air-puff system to capture and measure the elastic wave propagation from tissue surface. Experiments were performed on wildtype and dystrophic mouse diaphragm tissues containing different levels of fibrosis. The OCE measurements of elastic wave propagation were conducted along both the longitudinal and transverse axis of the muscle fibers. Cross-correlation of the temporal displacement profiles from different spatial locations was utilized to obtain the propagation time delay, which was used to calculate the wave group velocity and to further quantify the tissue Young's modulus. Prior to and after OCE assessment, peak tetanic force was measured to monitor viability of the tissue during the elasticity measurements. Our experimental results indicate a positive correlation between fibrosis level and tissue stiffness, suggesting this elastic-wave-based OCE method could be a useful tool to monitor mechanical properties of skeletal muscle under physiological and pathological conditions.

Biophotonics for imaging and cell manipulation: quo vadis?

NASA Astrophysics Data System (ADS)

Serafetinides, Alexandros A.; Makropoulou, Mirsini; Kotsifaki, Domna G.; Tsigaridas, Giorgos

2016-01-01

As one of the major health problems for mankind is cancer, any development for the early detection and effective treatment of cancer is crucial to saving lives. Worldwide, the dream for the anti-cancer procedure of attack is the development of a safe and efficient early diagnosis technique, the so called "optical biopsy". As early diagnosis of cancer is associated with improved prognosis, several laser based optical diagnostic methods were developed to enable earlier, non-invasive detection of human cancer, as Laser Induced Fluorescence spectroscopy (LIFs), Diffuse Reflectance spectroscopy (DRs), confocal microscopy, and Optical Coherence Tomography (OCT). Among them, Optical Coherence Tomography (OCT) imaging is considered to be a useful tool to differentiate healthy from malignant (e.g. basal cell carcinoma, squamous cell carcinoma) skin tissue. If the demand is to perform imaging in sub-tissular or even sub-cellular level, optical tweezers and atomic force microscopy have enabled the visualization of molecular events underlying cellular processes in live cells, as well as the manipulation and characterization of microscale or even nanoscale biostructures. In this work, we will present the latest advances in the field of laser imaging and manipulation techniques, discussing some representative experimental data focusing on the 21th century biophotonics roadmap of novel diagnostic and therapeutical approaches. As an example of a recently discussed health and environmental problem, we studied both experimentally and theoretically the optical trapping forces exerted on yeast cells and modified with estrogen-like acting compounds yeast cells, suspended in various buffer media.

Non-destructive geometric and refractive index characterization of single and multi-element lenses using optical coherence tomography

NASA Astrophysics Data System (ADS)

El-Haddad, Mohamed T.; Tao, Yuankai K.

2018-02-01

Design of optical imaging systems requires careful balancing of lens aberrations to optimize the point-spread function (PSF) and minimize field distortions. Aberrations and distortions are a result of both lens geometry and glass material. While most lens manufacturers provide optical models to facilitate system-level simulation, these models are often not reflective of true system performance because of manufacturing tolerances. Optical design can be further confounded when achromatic or proprietary lenses are employed. Achromats are ubiquitous in systems that utilize broadband sources due to their superior performance in balancing chromatic aberrations. Similarly, proprietary lenses may be custom-designed for optimal performance, but lens models are generally not available. Optical coherence tomography (OCT) provides non-contact, depth-resolved imaging with high axial resolution and sensitivity. OCT has been previously used to measure the refractive index of unknown materials. In a homogenous sample, the group refractive index is obtained as the ratio between the measured optical and geometric thicknesses of the sample. In heterogenous samples, a method called focus-tracking (FT) quantifies the effect of focal shift introduced by the sample. This enables simultaneous measurement of the thickness and refractive index of intermediate sample layers. Here, we extend the mathematical framework of FT to spherical surfaces, and describe a method based on OCT and FT for full characterization of lens geometry and refractive index. Finally, we validate our characterization method on commercially available singlet and doublet lenses.

A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future.

PubMed

Jonnal, Ravi S; Kocaoglu, Omer P; Zawadzki, Robert J; Liu, Zhuolin; Miller, Donald T; Werner, John S

2016-07-01

Optical coherence tomography (OCT) has enabled "virtual biopsy" of the living human retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here, we review work done over the last 15 years to combine the microscopic transverse resolution of AO with the microscopic axial resolution of OCT, building AO-OCT systems with the highest three-dimensional resolution of any existing retinal imaging modality. We surveyed the literature to identify the most influential antecedent work, important milestones in the development of AO-OCT technology, its applications that have yielded new knowledge, research areas into which it may productively expand, and nascent applications that have the potential to grow. Initial efforts focused on demonstrating three-dimensional resolution. Since then, many improvements have been made in resolution and speed, as well as other enhancements of acquisition and postprocessing techniques. Progress on these fronts has produced numerous discoveries about the anatomy, function, and optical properties of the retina. Adaptive optics OCT continues to evolve technically and to contribute to our basic and clinical knowledge of the retina. Due to its capacity to reveal cellular and microscopic detail invisible to clinical OCT systems, it is an ideal companion to those instruments and has the demonstrable potential to produce images that can guide the interpretation of clinical findings.

Applications of Optical Coherent Transient Technology to Pulse Shaping, Spectral Filtering, Arbitrary Waveform Generation and RF Beamforming

DTIC Science & Technology

2006-04-15

was amplified by injection locking of a high power diode laser and further amplified to -300 mW with a semiconductor optical amplifier. This light...amplifiers at 793nm, cascaded injection locked amplifiers at 793nm, and frequency chirped lasers at 793nm. 15. SUBJECT TERMS Optical Coherent Transients...injection- locking for broadband optical signal amplification ................. 34 2.10. Tapered semiconductor optical amplifier

Live dynamic imaging and analysis of developmental cardiac defects in mouse models with optical coherence tomography

NASA Astrophysics Data System (ADS)

Lopez, Andrew L.; Wang, Shang; Garcia, Monica; Valladolid, Christian; Larin, Kirill V.; Larina, Irina V.

2015-03-01

Understanding mouse embryonic development is an invaluable resource for our interpretation of normal human embryology and congenital defects. Our research focuses on developing methods for live imaging and dynamic characterization of early embryonic development in mouse models of human diseases. Using multidisciplinary methods: optical coherence tomography (OCT), live mouse embryo manipulations and static embryo culture, molecular biology, advanced image processing and computational modeling we aim to understand developmental processes. We have developed an OCT based approach to image live early mouse embryos (E8.5 - E9.5) cultured on an imaging stage and visualize developmental events with a spatial resolution of a few micrometers (less than the size of an individual cell) and a frame rate of up to hundreds of frames per second and reconstruct cardiodynamics in 4D (3D+time). We are now using these methods to study how specific embryonic lethal mutations affect cardiac morphology and function during early development.

Joint channel/frequency offset estimation and correction for coherent optical FBMC/OQAM system

NASA Astrophysics Data System (ADS)

Wang, Daobin; Yuan, Lihua; Lei, Jingli; wu, Gang; Li, Suoping; Ding, Runqi; Wang, Dongye

2017-12-01

In this paper, we focus on analysis of the preamble-based joint estimation for channel and laser-frequency offset (LFO) in coherent optical filter bank multicarrier systems with offset quadrature amplitude modulation (CO-FBMC/OQAM). In order to reduce the noise impact on the estimation accuracy, we proposed an estimation method based on inter-frame averaging. This method averages the cross-correlation function of real-valued pilots within multiple FBMC frames. The laser-frequency offset is estimated according to the phase of this average. After correcting LFO, the final channel response is also acquired by averaging channel estimation results within multiple frames. The principle of the proposed method is analyzed theoretically, and the preamble structure is thoroughly designed and optimized to suppress the impact of inherent imaginary interference (IMI). The effectiveness of our method is demonstrated numerically using different fiber and LFO values. The obtained results show that the proposed method can improve transmission performance significantly.

Extension of depth-resolved reconstruction of attenuation coefficients in optical coherence tomography for slim samples

NASA Astrophysics Data System (ADS)

Hohmann, Martin; Lengenfelder, B.; Kanawade, R.; Klämpfl, F.; Schmidt, Michael

2015-12-01

Coherent light propagating through turbid media is attenuated due to scattering and absorption. The decrease of the intensity of the coherent light is described by the attenuation coefficient. The measured decay of the coherent light through turbid media with optical coherence tomography (OCT) can be used to reconstruct the attenuation coefficient. Since most of the OCT systems work in the near-infrared region, they are the optical window from 800-1400 nm in tissue. Hence, the most part of the attenuation coefficient is caused due to the scattering. Therefore, deriving the attenuation coefficient is one way to get an approximation of the scattering coefficient which is difficult to access even up to day. Moreover, OCT measurements are one of the few possibilities to derive physical properties with micrometre resolution of the media under investigation.

GENERAL: Teleportation of a Bipartite Entangled Coherent State via a Four-Partite Cluster-Type Entangled State

NASA Astrophysics Data System (ADS)

Chen, Hui-Na; Liu, Jin-Ming

2009-10-01

We present an optical scheme to almost completely teleport a bipartite entangled coherent state using a four-partite cluster-type entangled coherent state as quantum channel. The scheme is based on optical elements such as beam splitters, phase shifters, and photon detectors. We also obtain the average fidelity of the teleportation process. It is shown that the average fidelity is quite close to unity if the mean photon number of the coherent state is not too small.

Electromagnetic-Optical Coherence Tomography Guidance of Transbronchial Solitary Pulmonary Nodule Biopsy

DTIC Science & Technology

2016-04-01

6 1. INTRODUCTION Lung cancer is the leading cause of cancer related death accounting for more deaths than breast , prostate and colon...the cancer has spread, at which time patients have little chance of cure. Macroscopic imaging modalities including CT and bronchoscopy have made...Electromagnetic Navigation , Biopsy Guidance, Optical Microscopy, Optical Coherence Tomography, Lung Cancer , Optical needle. 3. OVERALL PROJECT SUMMARY

Modulating the amplitude and phase of the complex spectral degree of coherence with plasmonic interferometry

NASA Astrophysics Data System (ADS)

Li, Dongfang; Pacifici, Domenico

The spectral degree of coherence describes the correlation of electromagnetic fields, which plays a key role in many applications, including free-space optical communications and speckle-free bioimaging. Recently, plasmonic interferometry, i.e. optical interferometry that employs surface plasmon polaritons (SPPs), has enabled enhanced light transmission and high-sensitivity biosensing, among other applications. It offers new ways to characterize and engineer electromagnetic fields using nano-structured thin metal films. Here, we employ plasmonic interferometry to demonstrate full control of spatial coherence at length scales comparable to the wavelength of the incident light. Specifically, by measuring the diffraction pattern of several double-slit plasmonic structures etched on a metal film, the amplitude and phase of the degree of spatial coherence is determined as a function of slit-slit separation distance and incident wavelength. When the SPP contribution is turned on (i.e., by changing the polarization of the incident light from TE to TM illumination mode), strong modulation of both amplitude and phase of the spatial coherence is observed. These findings may help design compact modulators of optical spatial coherence and other optical elements to shape the light intensity in the far-field.

Single-shot observation of optical rogue waves in integrable turbulence using time microscopy

PubMed Central

Suret, Pierre; Koussaifi, Rebecca El; Tikan, Alexey; Evain, Clément; Randoux, Stéphane; Szwaj, Christophe; Bielawski, Serge

2016-01-01

Optical fibres are favourable tabletop laboratories to investigate both coherent and incoherent nonlinear waves. In particular, exact solutions of the one-dimensional nonlinear Schrödinger equation such as fundamental solitons or solitons on finite background can be generated by launching periodic, specifically designed coherent waves in optical fibres. It is an open fundamental question to know whether these coherent structures can emerge from the nonlinear propagation of random waves. However the typical sub-picosecond timescale prevented—up to now—time-resolved observations of the awaited dynamics. Here, we report temporal ‘snapshots' of random light using a specially designed ‘time-microscope'. Ultrafast structures having peak powers much larger than the average optical power are generated from the propagation of partially coherent waves in optical fibre and are recorded with 250 femtoseconds resolution. Our experiment demonstrates the central role played by ‘breather-like' structures such as the Peregrine soliton in the emergence of heavy-tailed statistics in integrable turbulence. PMID:27713416

Adaptive restoration of a partially coherent blurred image using an all-optical feedback interferometer with a liquid-crystal device.

PubMed

Shirai, Tomohiro; Barnes, Thomas H

2002-02-01

A liquid-crystal adaptive optics system using all-optical feedback interferometry is applied to partially coherent imaging through a phase disturbance. A theoretical analysis based on the propagation of the cross-spectral density shows that the blurred image due to the phase disturbance can be restored, in principle, irrespective of the state of coherence of the light illuminating the object. Experimental verification of the theory has been performed for two cases when the object to be imaged is illuminated by spatially coherent light originating from a He-Ne laser and by spatially incoherent white light from a halogen lamp. We observed in both cases that images blurred by the phase disturbance were successfully restored, in agreement with the theory, immediately after the adaptive optics system was activated. The origin of the deviation of the experimental results from the theory, together with the effect of the feedback misalignment inherent in our optical arrangement, is also discussed.

Coherent fluorescence emission by using hybrid photonic–plasmonic crystals

PubMed Central

Shi, Lei; Yuan, Xiaowen; Zhang, Yafeng; Hakala, Tommi; Yin, Shaoyu; Han, Dezhuan; Zhu, Xiaolong; Zhang, Bo; Liu, Xiaohan; Törmä, Päivi; Lu, Wei; Zi, Jian

2014-01-01

The spatial and temporal coherence of the fluorescence emission controlled by a quasi-two-dimensional hybrid photonic–plasmonic crystal structure covered with a thin fluorescent-molecular-doped dielectric film is investigated experimentally. A simple theoretical model to describe how a confined quasi-two-dimensional optical mode may induce coherent fluorescence emission is also presented. Concerning the spatial coherence, it is experimentally observed that the coherence area in the plane of the light source is in excess of 49 μm2, which results in enhanced directional fluorescence emission. Concerning temporal coherence, the obtained coherence time is 4 times longer than that of the normal fluorescence emission in vacuum. Moreover, a Young's double-slit interference experiment is performed to directly confirm the spatially coherent emission. This smoking gun proof of spatial coherence is reported here for the first time for the optical-mode-modified emission. PMID:25793015

Combining Gabor and Talbot bands techniques to enhance the sensitivity with depth in Fourier domain optical coherence tomography

NASA Astrophysics Data System (ADS)

Bradu, Adrian; Marques, Manuel J.; Bouchal, Petr; Podoleanu, Adrian Gh.

2013-03-01

The purpose of this study was to show how to favorably mix two e_ects to improve the sensitivity with depth in Fourier domain optical coherence tomography (OCT): Talbot bands (TB) and Gabor-based fusion (GF) technique. TB operation is achieved by directing the two beams, from the object arm and from the reference arm in the OCT interferometer, along parallel separate paths towards the spectrometer. By changing the lateral gap between the two beams in their path towards the spectrometer, the position for the maximum sensitivity versus the optical path difference in the interferometer is adjusted. For five values of the focus position, the gap between the two beams is readjusted to reach maximum sensitivity. Then, similar to the procedure employed in the GF technique, a composite image is formed by edging together the parts of the five images that exhibited maximum brightness. The combined procedure, TB/GF is examined for four different values of the beam diameters of the two beams. Also we demonstrate volumetric FD-OCT images with mirror term attenuation and sensitivity profile shifted towards higher OPD values by applying a Talbot bands configuration.

A review of consensus test methods for established medical imaging modalities and their implications for optical coherence tomography

NASA Astrophysics Data System (ADS)

Pfefer, Joshua; Agrawal, Anant

2012-03-01

In recent years there has been increasing interest in development of consensus, tissue-phantom-based approaches for assessment of biophotonic imaging systems, with the primary goal of facilitating clinical translation of novel optical technologies. Well-characterized test methods based on tissue phantoms can provide useful tools for performance assessment, thus enabling standardization and device inter-comparison during preclinical development as well as quality assurance and re-calibration in the clinical setting. In this review, we study the role of phantom-based test methods as described in consensus documents such as international standards for established imaging modalities including X-ray CT, MRI and ultrasound. Specifically, we focus on three image quality characteristics - spatial resolution, spatial measurement accuracy and image uniformity - and summarize the terminology, metrics, phantom design/construction approaches and measurement/analysis procedures used to assess these characteristics. Phantom approaches described are those in routine clinical use and tend to have simplified morphology and biologically-relevant physical parameters. Finally, we discuss the potential for applying knowledge gained from existing consensus documents in the development of standardized, phantom-based test methods for optical coherence tomography.

Ultrafast acousto-optic mode conversion in optically birefringent ferroelectrics

NASA Astrophysics Data System (ADS)

Lejman, Mariusz; Vaudel, Gwenaelle; Infante, Ingrid C.; Chaban, Ievgeniia; Pezeril, Thomas; Edely, Mathieu; Nataf, Guillaume F.; Guennou, Mael; Kreisel, Jens; Gusev, Vitalyi E.; Dkhil, Brahim; Ruello, Pascal

2016-08-01

The ability to generate efficient giga-terahertz coherent acoustic phonons with femtosecond laser makes acousto-optics a promising candidate for ultrafast light processing, which faces electronic device limits intrinsic to complementary metal oxide semiconductor technology. Modern acousto-optic devices, including optical mode conversion process between ordinary and extraordinary light waves (and vice versa), remain limited to the megahertz range. Here, using coherent acoustic waves generated at tens of gigahertz frequency by a femtosecond laser pulse, we reveal the mode conversion process and show its efficiency in ferroelectric materials such as BiFeO3 and LiNbO3. Further to the experimental evidence, we provide a complete theoretical support to this all-optical ultrafast mechanism mediated by acousto-optic interaction. By allowing the manipulation of light polarization with gigahertz coherent acoustic phonons, our results provide a novel route for the development of next-generation photonic-based devices and highlight new capabilities in using ferroelectrics in modern photonics.

Access to long-term optical memories using photon echoes retrieved from electron spins in semiconductor quantum wells

NASA Astrophysics Data System (ADS)

Poltavtsev, S. V.; Langer, L.; Yugova, I. A.; Salewski, M.; Kapitonov, Y. V.; Yakovlev, D. R.; Karczewski, G.; Wojtowicz, T.; Akimov, I. A.; Bayer, M.

2016-10-01

We use spontaneous (two-pulse) and stimulated (three-pulse) photon echoes for studying the coherent evolution of optically excited ensemble of trions which are localized in semiconductor CdTe/CdMgTe quantum well. Application of transverse magnetic field leads to the Larmor precession of the resident electron spins, which shuffles optically induced polarization between optically accessible and inaccessible states. This results in several spectacular phenomena. First, magnetic field induces oscillations of spontaneous photon echo amplitude. Second, in three-pulse excitation scheme, the photon echo decay is extended by several orders of magnitude. In this study, short-lived optical excitation which is created by the first pulse is coherently transferred into a long-lived electron spin state using the second optical pulse. This coherent spin state of electron ensemble persists much longer than any optical excitation in the system, preserving information on initial optical field, which can be retrieved as a photon echo by means of third optical pulse.

Audio frequency in vivo optical coherence elastography

NASA Astrophysics Data System (ADS)

Adie, Steven G.; Kennedy, Brendan F.; Armstrong, Julian J.; Alexandrov, Sergey A.; Sampson, David D.

2009-05-01

We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

Joint optimization of a partially coherent Gaussian beam for free-space optical communication over turbulent channels with pointing errors.

PubMed

Lee, It Ee; Ghassemlooy, Zabih; Ng, Wai Pang; Khalighi, Mohammad-Ali

2013-02-01

Joint beam width and spatial coherence length optimization is proposed to maximize the average capacity in partially coherent free-space optical links, under the combined effects of atmospheric turbulence and pointing errors. An optimization metric is introduced to enable feasible translation of the joint optimal transmitter beam parameters into an analogous level of divergence of the received optical beam. Results show that near-ideal average capacity is best achieved through the introduction of a larger receiver aperture and the joint optimization technique.

Perception of power modulation of light in conjunction with acoustic stimulation

NASA Astrophysics Data System (ADS)

Hahlweg, Cornelius F.; Weyer, Cornelia; Gercke-Hahn, Harald; Gutzmann, Holger L.; Brahmann, Andre; Rothe, Hendrik

2013-09-01

The present paper is derived from an ongoing study on the human perception of combined optical and acoustical periodical stimuli. Originating from problems of occupational medicine concerning artificial illumination and certain machinery with coherent optical and acoustical emissions there are effects which are interesting in the context of Optics and Music. Because of the difficulties in evaluation of physical and psychological effects of such coherent stimuli in a first step we questioned if such coherence is perceivable at all. Concept, experimental set-up and first results are discussed in short.

Optical coherence tomography findings of bilateral foveal leukemic infiltration.

PubMed

Le, John Q; Braich, Puneet S; Brar, Vikram S

2016-01-01

We report a case of a 59-year-old man with a history of atypical chronic myelogenous leukemia who presented with a several-week history of decreased vision in both eyes. His clinical examination revealed bilateral foveal infiltration, which was also demonstrated on optical coherence tomography. After a failed induction with imatinib (Gleevec(®)), he was treated with omacetaxine (Synribo(®)) with an appropriate hematologic response. As his leukemia improved with chemotherapy, his retinal lesions regressed as demonstrated by serial optical coherence tomography and fundus photographs, with near complete restoration of foveal architecture.

Digital phase demodulation for low-coherence interferometry-based fiber-optic sensors

NASA Astrophysics Data System (ADS)

Liu, Y.; Strum, R.; Stiles, D.; Long, C.; Rakhman, A.; Blokland, W.; Winder, D.; Riemer, B.; Wendel, M.

2018-03-01

We describe a digital phase demodulation scheme for low-coherence interferometry-based fiber-optic sensors by employing a simple generation of phase-shifted signals at the interrogation interferometer. The scheme allows a real-time calibration process and offers capability of measuring large variations (up to the coherence of the light source) at the bandwidth that is only limited by the data acquisition system. The proposed phase demodulation method is analytically derived and its validity and performance are experimentally verified using fiber-optic Fabry-Perot sensors for measurement of strains and vibrations.

Transition to Complicated Behavior in Infinite Dimensional Dynamical Systems

DTIC Science & Technology

1990-03-01

solitons in nonlinear refractive periodic media," Phys. Lett. A. 141 37 (1989). A.3. Dynamics of Free-Running and Injection- Locked Laser Diode Arrays...Fibers * Dynamics of Free-Running and Injection- Locked Laser Diode Arrays I Diffraction/Diffusion Mediated Instabilities in Self-focusing/Defocusing...optics, the interplay between the coherence of solitons and the scattering (Anderson localization) effects of randomness, and the value in looking at

Quantitative measurement and real-time tracking of high intensity focused ultrasound using phase-sensitive optical coherence tomography: Feasibility study.

PubMed

Le, Nhan; Song, ShaoZhen; Nabi, Ghulam; Wang, Ruikang; Huang, Zhihong

2016-09-01

Phase-sensitive optical coherence tomography (PhS-OCT) is proposed, as a new high intensity focused ultrasound (HIFU) imaging guidance to detect and track HIFU focus inside 1% agar samples in this work. The experiments studied the effect of varying HIFU power on the induction of shear wave, which can be implemented as a new technique to monitor focused ultrasound surgery (FUS). A miniature HIFU transducer (1.02 MHz, 20 mm aperture diameter, 15 mm radius of curvature) was produced in-house, pressure-field mapped, and calibrated. The transducer was then embedded inside a 1% agar phantom, which was placed under PhS-OCT for observation, under various HIFU power settings (acoustic power, and number of cycles per pulse). Shear wave was induced on the sample surface by HIFU and was captured in full under PhS-OCT. The lowest HIFU acoustic power output for the detection of shear wave was found to be 0.36 W (1.02 MHz, 100 cycles/pulse), or with the number of cycles/pulse as low as 20 (1.02 MHz, 0.98 W acoustic power output). A linear relationship between acoustic power output and the maximum shear wave displacement was found in the first study. The second study explores a non-linear correlation between the (HIFU) numbers of cycles per pulse, and the maximum shear wave displacement. PhS-OCT demonstrates excellent tracking and detection of HIFU-induced shear wave. The results could benefit other imaging techniques in tracking and guiding HIFU focus. Further studies will explore the relationship between the physical transducer characteristics and the HIFU-induced shear wave.

Coherent Doppler Wind Lidar Technology for Space Based Wind Measurements Including SPARCLE

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.; Singh, Upendra N.

1999-01-01

It has been over 30 years since coherent lidar systems first measured wind velocity, and over 20 years since the "ultimate application" of measuring Earth's winds from space was conceived. Coherent or heterodyne optical detection involves the combination (or mixing) of the returned optical field with a local oscillator (LO) laser's optical field on the optical detector. This detection technique yields the benefits of dramatically improved signal-to-noise ratios; insensitivity to detector noise, background light and multiply scattered light; reduction of the returned signal's dynamic range; and preservation of the optical signal spectrum for electronic and computer processing. (Note that lidar systems are also referred to as optical radar, laser radar, and LADAR systems.) Many individuals, agencies, and countries have pursued the goal of space-based wind measurements through technology development, experiments, field campaigns and studies.

High efficiency coherent optical memory with warm rubidium vapour

PubMed Central

Hosseini, M.; Sparkes, B.M.; Campbell, G.; Lam, P.K.; Buchler, B.C.

2011-01-01

By harnessing aspects of quantum mechanics, communication and information processing could be radically transformed. Promising forms of quantum information technology include optical quantum cryptographic systems and computing using photons for quantum logic operations. As with current information processing systems, some form of memory will be required. Quantum repeaters, which are required for long distance quantum key distribution, require quantum optical memory as do deterministic logic gates for optical quantum computing. Here, we present results from a coherent optical memory based on warm rubidium vapour and show 87% efficient recall of light pulses, the highest efficiency measured to date for any coherent optical memory suitable for quantum information applications. We also show storage and recall of up to 20 pulses from our system. These results show that simple warm atomic vapour systems have clear potential as a platform for quantum memory. PMID:21285952

High efficiency coherent optical memory with warm rubidium vapour.

PubMed

Hosseini, M; Sparkes, B M; Campbell, G; Lam, P K; Buchler, B C

2011-02-01

By harnessing aspects of quantum mechanics, communication and information processing could be radically transformed. Promising forms of quantum information technology include optical quantum cryptographic systems and computing using photons for quantum logic operations. As with current information processing systems, some form of memory will be required. Quantum repeaters, which are required for long distance quantum key distribution, require quantum optical memory as do deterministic logic gates for optical quantum computing. Here, we present results from a coherent optical memory based on warm rubidium vapour and show 87% efficient recall of light pulses, the highest efficiency measured to date for any coherent optical memory suitable for quantum information applications. We also show storage and recall of up to 20 pulses from our system. These results show that simple warm atomic vapour systems have clear potential as a platform for quantum memory.

On important precursor of singular optics (tutorial)

NASA Astrophysics Data System (ADS)

Polyanskii, Peter V.; Felde, Christina V.; Bogatyryova, Halina V.; Konovchuk, Alexey V.

2018-01-01

The rise of singular optics is usually associated with the seminal paper by J. F. Nye and M. V. Berry [Proc. R. Soc. Lond. A, 336, 165-189 (1974)]. Intense development of this area of modern photonics has started since the early eighties of the XX century due to invention of the interfrence technique for detection and diagnostics of phase singularities, such as optical vortices in complex speckle-structured light fields. The next powerful incentive for formation of singular optics into separate area of the science on light was connectected with discovering of very practical technique for creation of singular optical beams of various kinds on the base of computer-generated holograms. In the eghties and ninetieth of the XX century, singular optics evolved, almost entirely, under the approximation of complete coherency of light field. Only at the threshold of the XXI century, it has been comprehended that the singular-optics approaches can be fruitfully expanded onto partially spatially coherent, partially polarized and polychromatic light fields supporting singularities of new kinds, that has been resulted in establishing of correlation singular optics. Here we show that correlation singular optics has much deeper roots, ascending to "pre-singular" and even pre-laser epoch and associated with the concept of partial coherence and polarization. It is remarcable that correlation singular optics in its present interpretation has forestalled the standard coherent singular optics. This paper is timed to the sixtieth anniversary of the most profound precursor of modern correlation singular optics [J. Opt. Soc. Am., 47, 895-902 (1957)].

Demonstration of a memory for tightly guided light in an optical nanofiber.

PubMed

Gouraud, B; Maxein, D; Nicolas, A; Morin, O; Laurat, J

2015-05-08

We report the experimental observation of slow-light and coherent storage in a setting where light is tightly confined in the transverse directions. By interfacing a tapered optical nanofiber with a cold atomic ensemble, electromagnetically induced transparency is observed and light pulses at the single-photon level are stored in and retrieved from the atomic medium. The decay of efficiency with storage time is also measured and related to concurrent decoherence mechanisms. Collapses and revivals can be additionally controlled by an applied magnetic field. Our results based on subdiffraction-limited optical mode interacting with atoms via the strong evanescent field demonstrate an alternative to free-space focusing and a novel capability for information storage in an all-fibered quantum network.

Theoretical Investigation of Optical Detection and Recognition of Single Biological Molecules Using Coherent Dynamics of Exciton-Plasmon Coupling

PubMed Central

Sadeghi, S. M.; Hood, B.; Patty, K. D.; Mao, C.-B.

2013-01-01

We use quantum coherence in a system consisting of one metallic nanorod and one semi-conductor quantum dot to investigate a plasmonic nanosensor capable of digital optical detection and recognition of single biological molecules. In such a sensor the adsorption of a specific molecule to the nanorod turns off the emission of the system when it interacts with an optical pulse having a certain intensity and temporal width. The proposed quantum sensors can count the number of molecules of the same type or differentiate between molecule types with digital optical signals that can be measured with high certainty. We show that these sensors are based on the ultrafast upheaval of coherent dynamics of the system and the removal of coherent blockage of energy transfer from the quantum dot to the nanorod once the adsorption process has occurred. PMID:24040424

Combined spectral-domain optical coherence tomography and hyperspectral imaging applied for tissue analysis: Preliminary results

NASA Astrophysics Data System (ADS)

Dontu, S.; Miclos, S.; Savastru, D.; Tautan, M.

2017-09-01

In recent years many optoelectronic techniques have been developed for improvement and the development of devices for tissue analysis. Spectral-Domain Optical Coherence Tomography (SD-OCT) is a new medical interferometric imaging modality that provides depth resolved tissue structure information with resolution in the μm range. However, SD-OCT has its own limitations and cannot offer the biochemical information of the tissue. These data can be obtained with hyperspectral imaging, a non-invasive, sensitive and real time technique. In the present study we have combined Spectral-Domain Optical Coherence Tomography (SD-OCT) with Hyperspectral imaging (HSI) for tissue analysis. The Spectral-Domain Optical Coherence Tomography (SD-OCT) and Hyperspectral imaging (HSI) are two methods that have demonstrated significant potential in this context. Preliminary results using different tissue have highlighted the capabilities of this technique of combinations.

Improved measurement of vibration amplitude in dynamic optical coherence elastography

PubMed Central

Kennedy, Brendan F.; Wojtkowski, Maciej; Szkulmowski, Maciej; Kennedy, Kelsey M.; Karnowski, Karol; Sampson, David D.

2012-01-01

Abstract: Optical coherence elastography employs optical coherence tomography (OCT) to measure the displacement of tissues under load and, thus, maps the resulting strain into an image, known as an elastogram. We present a new improved method to measure vibration amplitude in dynamic optical coherence elastography. The tissue vibration amplitude caused by sinusoidal loading is measured from the spread of the Doppler spectrum, which is extracted using joint spectral and time domain signal processing. At low OCT signal-to-noise ratio (SNR), the method provides more accurate vibration amplitude measurements than the currently used phase-sensitive method. For measurements performed on a mirror at OCT SNR = 5 dB, our method introduces <3% error, compared to >20% using the phase-sensitive method. We present elastograms of a tissue-mimicking phantom and excised porcine tissue that demonstrate improvements, including a 50% increase in the depth range of reliable vibration amplitude measurement. PMID:23243565

Optical sectioning in induced coherence tomography with frequency-entangled photons

NASA Astrophysics Data System (ADS)

Vallés, Adam; Jiménez, Gerard; Salazar-Serrano, Luis José; Torres, Juan P.

2018-02-01

We demonstrate a different scheme to perform optical sectioning of a sample based on the concept of induced coherence [Zou et al., Phys. Rev. Lett. 67, 318 (1991), 10.1103/PhysRevLett.67.318]. This can be viewed as a different type of optical coherence tomography scheme where the varying reflectivity of the sample along the direction of propagation of an optical beam translates into changes of the degree of first-order coherence between two beams. As a practical advantage the scheme allows probing the sample with one wavelength and measuring photons with another wavelength. In a bio-imaging scenario, this would result in a deeper penetration into the sample because of probing with longer wavelengths, while still using the optimum wavelength for detection. The scheme proposed here could achieve submicron axial resolution by making use of nonlinear parametric sources with broad spectral bandwidth emission.

Probing coherence in microcavity frequency combs via optical pulse shaping

NASA Astrophysics Data System (ADS)

Ferdous, Fahmida; Miao, Houxun; Wang, Pei-Hsun; Leaird, Daniel E.; Srinivasan, Kartik; Chen, Lei; Aksyuk, Vladimir; Weiner, Andrew M.

2012-09-01

Recent investigations of microcavity frequency combs based on cascaded four-wave mixing have revealed a link between the evolution of the optical spectrum and the observed temporal coherence. Here we study a silicon nitride microresonator for which the initial four-wave mixing sidebands are spaced by multiple free spectral ranges (FSRs) from the pump, then fill in to yield a comb with single FSR spacing, resulting in partial coherence. By using a pulse shaper to select and manipulate the phase of various subsets of spectral lines, we are able to probe the structure of the coherence within the partially coherent comb. Our data demonstrate strong variation in the degree of mutual coherence between different groups of lines and provide support for a simple model of partially coherent comb formation.

SPECIAL ISSUE ON OPTICAL PROCESSING OF INFORMATION: Phase of an optical wave as an additional degree of freedom in optical information processing systems based on optical bistability

NASA Astrophysics Data System (ADS)

Basharov, Askhat M.

1995-10-01

It is shown theoretically that additional illumination by a squeezed field of a thin layer of two-level atoms, which interact with a resonant coherent electromagnetic wave, results in bistable transmission/reflection of this wave. This bistability depends strongly on the difference between the phases of the coherent and squeezed fields.

Free-space coherent optical communication receivers implemented with photorefractive optical beam combiners

NASA Technical Reports Server (NTRS)

Davidson, Frederic M.

1992-01-01

Performance measurements are reported concerning a coherent optical communication receiver that contained an iron doped indium phosphide photorefractive beam combiner, rather than a conventional optical beam splitter. The system obtained a bit error probability of 10(exp -6) at received signal powers corresponding to less than 100 detected photons per bit. The system used phase modulated Nd:YAG laser light at a wavelength of 1.06 microns.

Comparison of optic area measurement using fundus photography and optical coherence tomography between optic nerve head drusen and control subjects.

PubMed

Flores-Rodríguez, Patricia; Gili, Pablo; Martín-Ríos, María Dolores; Grifol-Clar, Eulalia

2013-03-01

To compare optic disc area measurement between optic nerve head drusen (ONHD) and control subjects using fundus photography, time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT). We also made a comparison between each of the three techniques. We performed our study on 66 eyes (66 patients) with ONHD and 70 healthy control subjects (70 controls) with colour ocular fundus photography at 20º (Zeiss FF 450 IR plus), TD-OCT (Stratus OCT) with the Fast Optic Disc protocol and SD-OCT (Cirrus OCT) with the Optic Disc Cube 200 × 200 protocol for measurement of the optic disc area. The measurements were made by two observers and in each measurement a correction of the image magnification factor was performed. Measurement comparison using the Student's t-test/Mann-Whitney U test, the intraclass correlation coefficient, Pearson/Spearman rank correlation coefficient and the Bland-Altman plot was performed in the statistical analysis. Mean and standard deviation (SD) of the optic disc area in ONHD and in controls was 2.38 (0.54) mm(2) and 2.54 (0.42) mm(2), respectively with fundus photography; 2.01 (0.56) mm(2) and 1.66 (0.37) mm(2), respectively with TD-OCT, and 2.03 (0.49) mm(2) and 1.75 (0.38) mm(2), respectively with SD-OCT. In ONHD and controls, repeatability of optic disc area measurement was excellent with fundus photography and optical coherence tomography (TD-OCT and SD-OCT), but with a low degree of agreement between both techniques. Optic disc area measurement is smaller in ONHD compared to healthy subjects with fundus photography, unlike time-domain and spectral-domain optical coherence tomography in which the reverse is true. Both techniques offer good repeatability, but a low degree of correlation and agreement, which means that optic disc area measurement is not interchangeable or comparable between techniques. Ophthalmic & Physiological Optics © 2013 The College of Optometrists.

Conceptual design of a coherent optical system of modular imaging collectors (COSMIC). [telescope array deployed by space shuttle in 1990's

NASA Technical Reports Server (NTRS)

Nein, M. E.; Davis, B. G.

1982-01-01

The Coherent Optical System of Modular Imaging Collectors (COSMIC) is the design concept for a phase-coherent optical telescope array that may be placed in earth orbit by the Space Shuttle in the 1990s. The initial system module is a minimum redundancy array whose photon collecting area is three times larger than that of the Space Telescope, and possesses a one-dimensional resoution of better than 0.01 arcsec in the visible range. Thermal structural requirements are assessed. Although the coherent beam combination requirements will be met by an active control system, the COSMIC structural/thermal design must meet more stringent performance criteria than even those of the Space Telescope.

Optical communication with two-photon coherent stages. I - Quantum-state propagation and quantum-noise reduction

NASA Technical Reports Server (NTRS)

Yuen, H. P.; Shapiro, J. H.

1978-01-01

To determine the ultimate performance limitations imposed by quantum effects, it is also essential to consider optimum quantum-state generation. Certain 'generalized' coherent states of the radiation field possess novel quantum noise characteristics that offer the potential for greatly improved optical communications. These states have been called two-photon coherent states because they can be generated, in principle, by stimulated two-photon processes. The use of two-photon coherent state (TCS) radiation in free-space optical communications is considered. A simple theory of quantum state propagation is developed. The theory provides the basis for representing the free-space channel in a quantum-mechanical form convenient for communication analysis. The new theory is applied to TCS radiation.

Spatial coherence effect on layer thickness determination in narrowband full-field optical coherence tomography.

PubMed

Safrani, Avner; Abdulhalim, Ibrahim

2011-06-20

Longitudinal spatial coherence (LSC) is determined by the spatial frequency content of an optical beam. The use of lenses with a high numerical aperture (NA) in full-field optical coherence tomography and a narrowband light source makes the LSC length much shorter than the temporal coherence length, hence suggesting that high-resolution 3D images of biological and multilayered samples can be obtained based on the low LSC. A simplified model is derived, supported by experimental results, which describes the expected interference output signal of multilayered samples when high-NA lenses are used together with a narrowband light source. An expression for the correction factor for the layer thickness determination is found valid for high-NA objectives. Additionally, the method was applied to a strongly scattering layer, demonstrating the potential of this method for high-resolution imaging of scattering media.

Investigation of coherent receiver designs in high-speed optical inter-satellite links using digital signal processing

NASA Astrophysics Data System (ADS)

Schaefer, S.; Gregory, M.; Rosenkranz, W.

2017-09-01

Due to higher data rates, better data security and unlicensed spectral usage optical inter-satellite links (OISL) offer an attractive alternative to conventional RF-communication. However, the very high transmission distances necessitate an optical receiver design enabling high receiver sensitivity which requires careful carrier synchronization and a quasi-coherent detection scheme.

The Development, Commercialization, and Impact of Optical Coherence Tomography

PubMed Central

Fujimoto, James; Swanson, Eric

2016-01-01

This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest. PMID:27409459

Fundus autofluorescence and optical coherence tomography of congenital grouped albinotic spots.

PubMed

Kim, David Y; Hwang, John C; Moore, Anthony T; Bird, Alan C; Tsang, Stephen H

2010-09-01

The purpose of this study was to describe the findings of fundus autofluores-cence (FAF) and optical coherence tomography in a series of patients with congenital grouped albinotic spots. Three eyes of three patients with congenital grouped albinotic spots were evaluated with FAF and optical coherence tomography imaging to evaluate the nature of the albinotic spots. In all three eyes with congenital grouped albinotic spots, FAF imaging showed autofluorescent spots corresponding to the albinotic spots seen on stereo biomicroscopy. One eye also had additional spots detected on FAF imaging that were not visible on stereo biomicroscopy or color fundus photographs. Fundus autofluorescence imaging of the spots showed decreased general autofluorescence and decreased peripheral autofluorescence surrounding central areas of retained or increased autofluorescence. Optical coherence tomography showed a disruption in signal from the hyperreflective layer corresponding to the inner and outer segment junction and increased signal backscattering from the choroid in the area of the spots. Fluorescein angiography showed early and stable hyperfluorescence of the spots without leakage. In this case series, FAF showed decreased autofluorescence of the spots consistent with focal retinal pigment epithelium atrophy or abnormal material blocking normal autofluorescence and areas of increased autofluorescence suggesting retinal pigment epithelium dysfunction. The findings of optical coherence tomography and fluorescein angiography suggest photoreceptor and retinal pigment epithelium layer abnormalities. Fundus autofluorescence and optical coherence tomography are useful noninvasive diagnostic adjuncts that can aid in the diagnosis of congenital grouped albinotic spots, help determine extent of disease, and contribute to our understanding of its pathophysiology.

ULTRAHIGH SPEED SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL AND CHORIOCAPILLARIS ALTERATIONS IN DIABETIC PATIENTS WITH AND WITHOUT RETINOPATHY.

PubMed

Choi, WooJhon; Waheed, Nadia K; Moult, Eric M; Adhi, Mehreen; Lee, ByungKun; De Carlo, Talisa; Jayaraman, Vijaysekhar; Baumal, Caroline R; Duker, Jay S; Fujimoto, James G

2017-01-01

To investigate the utility of ultrahigh speed, swept source optical coherence tomography angiography in visualizing retinal microvascular and choriocapillaris (CC) changes in diabetic patients. The study was prospective and cross-sectional. A 1,050 nm wavelength, 400 kHz A-scan rate swept source optical coherence tomography prototype was used to perform volumetric optical coherence tomography angiography of the retinal and CC vasculatures in diabetic patients and normal subjects. Sixty-three eyes from 32 normal subjects, 9 eyes from 7 patients with proliferative diabetic retinopathy, 29 eyes from 16 patients with nonproliferative diabetic retinopathy, and 51 eyes from 28 diabetic patients without retinopathy were imaged. Retinal and CC microvascular abnormalities were observed in all stages of diabetic retinopathy. In nonproliferative diabetic retinopathy and proliferative diabetic retinopathy, optical coherence tomography angiography visualized a variety of vascular abnormalities, including clustered capillaries, dilated capillary segments, tortuous capillaries, regions of capillary dropout, reduced capillary density, abnormal capillary loops, and foveal avascular zone enlargement. In proliferative diabetic retinopathy, retinal neovascularization above the inner limiting membrane was visualized. Regions of CC flow impairment in patients with proliferative diabetic retinopathy and nonproliferative diabetic retinopathy were also observed. In 18 of the 51 of eyes from diabetic patients without retinopathy, retinal mircrovascular abnormalities were observed and CC flow impairment was found in 24 of the 51 diabetic eyes without retinopathy. The ability of optical coherence tomography angiography to visualize retinal and CC microvascular abnormalities suggests it may be a useful tool for understanding pathogenesis, evaluating treatment response, and earlier detection of vascular abnormalities in patients with diabetes.

Harmonic scalpel versus electrocautery for harvest of radial artery conduits: Reduced risk of spasm and intimal injury on optical coherence tomography

PubMed Central

Brazio, Philip S.; Laird, Patrick C.; Xu, Chenyang; Gu, Junyan; Burris, Nicholas S.; Brown, Emile N.; Kon, Zachary N.; Poston, Robert S.

2009-01-01

Objective Vasospasm is the primary obstacle to widespread adoption of the radial artery as a conduit in coronary artery bypass grafting. We used optical coherence tomography, a catheter-based intravascular imaging modality, to measure the degree of radial artery spasm induced by means of harvest with electrocautery or a harmonic scalpel in patients undergoing coronary artery bypass grafting. Methods Radial arteries were harvested from 44 consecutive patients with a harmonic scalpel (n = 15) or electrocautery (n = 29). Vessels were imaged before harvesting and after removal from the arm, with saphenous vein tracts serving as internal controls. Optical coherence tomographic findings for the degree of harvesting-induced injury were validated against histologic measures. Results Optical coherence tomographic measures of endovascular dimensions and injury correlated strongly with histologic findings. Mean luminal volume, a measure of vasospasm, decreased significantly less after harvesting with a harmonic scalpel (9% ± 7%) than with electrocautery (35% ± 6%, P = .015). Completely intact intima was present in 11 (73%) of 15 radial arteries harvested with a harmonic scalpel (73%) compared with 9 of 29 arteries harvested by means of electrocautery (31%, P = .011). Intraoperative flow measurements and patency rates at 5 days postoperatively were not significantly different among groups. Conclusions Optical coherence tomography provides a level of speed and accuracy for quantifying endothelial injury and vasospasm that has not been described for any other modality, suggesting potential as an intraoperative quality assurance tool. Our optical coherence tomographic findings suggest that the harmonic scalpel induces less spasm and intimal injury compared with electrocautery. PMID:19026820

The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography

NASA Astrophysics Data System (ADS)

Ugryumova, Nadya; Attenburrow, Don P.; Winlove, C. Peter; Matcher, Stephen J.

2005-08-01

Optical coherence tomography and polarization-sensitive optical coherence tomography images of equine articular cartilage are presented. Measurements were made on intact joint surfaces. Significant (e.g. × 2) variations in the intrinsic birefringence were found over spatial scales of a few millimetres, even on samples taken from young (18 month) animals that appeared visually homogeneous. A comparison of data obtained on a control tissue (equine flexor tendon) further suggests that significant variations in the orientation of the collagen fibres relative to the plane of the joint surface exist. Images of visually damaged cartilage tissue show characteristic features both in terms of the distribution of optical scatterers and of the birefringent components.

General interference law for nonstationary, separable optical fields.

PubMed

Manea, Vladimir

2009-09-01

An approach to the theory of partial coherence for nonstationary optical fields is presented. Starting with a spectral representation, a favorable decomposition of the optical signals is discussed that supports a natural extension of the mathematical formalism. The coherence functions are redefined, but still as temporal correlation functions, allowing the obtaining of a more general form of the interference law for partially coherent optical signals. The general theory is applied in some relevant particular cases of nonstationary interference, namely, with quasi-monochromatic beams of different frequencies and with phase-modulated quasi-monochromatic beams of similar frequency spectra. All the results of the general treatment are reducible to the ones given in the literature for the case of stationary interference.

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part III): in vivo endoscopic imaging of blood flow in the rat and human gastrointestinal tracts

NASA Astrophysics Data System (ADS)

Yang, Victor X. D.; Gordon, Maggie L.; Tang, Shou-Jiang; Marcon, Norman E.; Gardiner, Geoffrey; Qi, Bing; Bisland, Stuart; Seng-Yue, Emily; Lo, Stewart; Pekar, Julius; Wilson, Brian C.; Vitkin, I. Alex

2003-09-01

We previously described a fiber based Doppler optical coherence tomography system [1] capable of imaging embryo cardiac blood flow at 4~16 frames per second with wide velocity dynamic range [2]. Coupling this system to a linear scanning fiber optical catheter design that minimizes friction and vibrations, we report here the initial results of in vivo endoscopic Doppler optical coherence tomography (EDOCT) imaging in normal rat and human esophagus. Microvascular flow in blood vessels less than 100 µm diameter was detected using a combination of color-Doppler and velocity variance imaging modes, during clinical endoscopy using a mobile EDOCT system.

Prototype of a coherent tracking and detection receiver with wideband vibration compensation for free-space laser communications

NASA Astrophysics Data System (ADS)

Giggenbach, Dirk; Schex, Anton; Wandernoth, Bernhard

1996-04-01

The Optical Communications Group of the German Aerospace Research Establishment (DLR) has investigated the feasibility of a fiberless receiver telescope for high sensitive coherent optical space communication, resulting in an elegant pointing, acquisition and tracking (PAT) concept. To demonstrate the feasibility of this new concept, an optical receiver terminal that coherently obtains both the spatial error signal for tracking and the data signal with only one set of detectors has been built. The result is a very simple and compact setup with few optical surfaces. It does not require fibers for superpositioning and is capable to compensate for microaccelerations up to about one kilohertz.

Micromachined array tip for multifocus fiber-based optical coherence tomography.

PubMed

Yang, Victor X D; Munce, Nigel; Pekar, Julius; Gordon, Maggie L; Lo, Stewart; Marcon, Norman E; Wilson, Brian C; Vitkin, I Alex

2004-08-01

High-resolution optical coherence tomography demands a large detector bandwidth and a high numerical aperture for real-time imaging, which is difficult to achieve over a large imaging depth. To resolve these conflicting requirements we propose a novel multifocus fiber-based optical coherence tomography system with a micromachined array tip. We demonstrate the fabrication of a prototype four-channel tip that maintains a 9-14-microm spot diameter with more than 500 microm of imaging depth. Images of a resolution target and a human tooth were obtained with this tip by use of a four-channel cascaded Michelson fiber-optic interferometer, scanned simultaneously at 8 kHz with geometric power distribution across the four channels.

Two improved coherent optical feedback systems for optical information processing

NASA Technical Reports Server (NTRS)

Lee, S. H.; Bartholomew, B.; Cederquist, J.

1976-01-01

Coherent optical feedback systems are Fabry-Perot interferometers modified to perform optical information processing. Two new systems based on plane parallel and confocal Fabry-Perot interferometers are introduced. The plane parallel system can be used for contrast control, intensity level selection, and image thresholding. The confocal system can be used for image restoration and solving partial differential equations. These devices are simpler and less expensive than previous systems. Experimental results are presented to demonstrate their potential for optical information processing.

High-resolution retinal imaging using adaptive optics and Fourier-domain optical coherence tomography

DOEpatents

Olivier, Scot S.; Werner, John S.; Zawadzki, Robert J.; Laut, Sophie P.; Jones, Steven M.

2010-09-07

This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times.4.times.6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Ray-optical theory of broadband partially coherent emission

NASA Astrophysics Data System (ADS)

Epstein, Ariel; Tessler, Nir; Einziger, Pinchas D.

2013-04-01

We present a rigorous formulation of the effects of spectral broadening on emission of partially coherent source ensembles embedded in multilayered formations with arbitrarily shaped interfaces, provided geometrical optics is valid. The resulting ray-optical theory, applicable to a variety of optical systems from terahertz lenses to photovoltaic cells, quantifies the fundamental interplay between bandwidth and layer dimensions, and sheds light on common practices in optical analysis of statistical fields, e.g., disregarding multiple reflections or neglecting interference cross terms.

Fiber-optic-bundle-based optical coherence tomography.

PubMed

Xie, Tuqiang; Mukai, David; Guo, Shuguang; Brenner, Matthew; Chen, Zhongping

2005-07-15

A fiber-optic-bundle-based optical coherence tomography (OCT) probe method is presented. The experimental results demonstrate this multimode optical fiber-bundle-based OCT system can achieve a lateral resolution of 12 microm and an axial resolution of 10 microm with a superluminescent diode source. This novel OCT imaging approach eliminates any moving parts in the probe and has a primary advantage for use in extremely compact and safe OCT endoscopes for imaging internal organs and great potential to be combined with confocal endoscopic microscopy.

Two mode optical fiber in space optics communication

NASA Astrophysics Data System (ADS)

Hampl, Martin

2017-11-01

In our contribution we propose to use of a two-mode optical fiber as a primary source in a transmitting optical head instead of the laser diode. The distribution of the optical intensity and the complex degree of the coherence on the output aperture of the lens that is irradiated by a step-index weakly guiding optical fiber is investigated. In our treatment we take into account weakly guided modes with polarization corrections to the propagation constant and unified theory of second order coherence and polarization of electromagnetic beams.

Simultaneous transfer of optical frequency and time over 306 km long-haul optical fibre link

NASA Astrophysics Data System (ADS)

Hucl, Vaclav; Cizek, Martin; Pravdova, Lenka; Rerucha, Simon; Hrabina, Jan; Mikel, Bretislav; Smotlacha, Vladimir; Vojtech, Josef; Lazar, Josef; Cip, Ondrej

2016-12-01

Optical fibre links for distributing optical frequencies and time stamps were researched and experimentally tested in the past fifteen years. They have been used mainly for stability comparison of experimental optical clocks. But recent development puts demands on a technology transfer from laboratory experiments to the real industry. The remote calibration of interrogators of Fibre Bragg Grating strain sensory networks is one of important examples. The first step of the adoption the time and frequency broadcasting should be the drop-out free long-term operation of this technology between research laboratories connected via long-haul fibre links. We present a 306 km long-haul optical fibre link between the cities of Prague and Brno in the Czech Republic where a coherent transfer of stable optical frequency and a stable time signal has been firstly demonstrated. The link between ISI CAS Brno and CESNET Prague uses an internet communication fibre where a window of 1540-1546 nm is dedicated for the coherent transfer and 1PPS signal. The link is equipped with 6 bidirectional EDFA amplifiers. The optical frequency standard based on the highly-coherent laser Koheras Adjustik working at 1540.5 nm and stabilized with a saturation absorption spectroscopy technique was used for the coherent wave transfer. The suppression of the Doppler shift induced by the optical fibre was based on an accoustooptical modulator with a servo-loop including a fast PID controller processing the beat-note frequency given by mixing of the Adjustik laser (Brno) and the reflected frequency of this laser from the far end of 306 km long-haul fibre link (Prague). We verified the Doppler shift suppression for the coherent wave with a measuring method analysing the transport delay of the 1PPS signal.

Optical Communications Experiments at 6328 A and 10.6 micro.

PubMed

Lucy, R F; Lang, K

1968-10-01

Diagnostic optical communication experiments were performed comparing noncoherent and coherent detection techniques. Three different receiver-transmitter configurations with variable apertures were used during the experiments that were performed over a 1-km real atmospheric path. In every case, it was found that the coherent system fading, due to atmospheric turbulence, was considerably greater than the noncoherent system fading. This result shows the greater sensitivity of the coherent system to the time-varying wavefront breakup produced by atmospheric turbulence. A coherent homodyne experiment at 10.6 micro over a 2-km round-trip path was also performed. Its results indicated that a coherent system at 10.6 micro is less susceptible to atmospheric turbulence than a coherent system at 6328 A.

Emergence of electron coherence and two-color all-optical switching in MoS2 based on spatial self-phase modulation

PubMed Central

Wu, Yanling; Wu, Qiong; Sun, Fei; Cheng, Cai; Meng, Sheng; Zhao, Jimin

2015-01-01

Generating electron coherence in quantum materials is essential in optimal control of many-body interactions and correlations. In a multidomain system this signifies nonlocal coherence and emergence of collective phenomena, particularly in layered 2D quantum materials possessing novel electronic structures and high carrier mobilities. Here we report nonlocal ac electron coherence induced in dispersed MoS2 flake domains, using coherent spatial self-phase modulation (SSPM). The gap-dependent nonlinear dielectric susceptibility χ(3) measured is surprisingly large, where direct interband transition and two-photon SSPM are responsible for excitations above and below the bandgap, respectively. A wind-chime model is proposed to account for the emergence of the ac electron coherence. Furthermore, all-optical switching is achieved based on SSPM, especially with two-color intraband coherence, demonstrating that electron coherence generation is a ubiquitous property of layered quantum materials. PMID:26351696

Quantum-Fluctuation-Initiated Coherence in Multioctave Raman Optical Frequency Combs

NASA Astrophysics Data System (ADS)

Wang, Y. Y.; Wu, Chunbai; Couny, F.; Raymer, M. G.; Benabid, F.

2010-09-01

We show experimentally and theoretically that the spectral components of a multioctave frequency comb spontaneously created by stimulated Raman scattering in a hydrogen-filled hollow-core photonic crystal fiber exhibit strong self-coherence and mutual coherence within each 12 ns driving laser pulse. This coherence arises in spite of the field’s initiation being from quantum zero-point fluctuations, which causes each spectral component to show large phase and energy fluctuations. This points to the possibility of an optical frequency comb with nonclassical correlations between all comb lines.

Adaptive-optics optical coherence tomography processing using a graphics processing unit.

PubMed

Shafer, Brandon A; Kriske, Jeffery E; Kocaoglu, Omer P; Turner, Timothy L; Liu, Zhuolin; Lee, John Jaehwan; Miller, Donald T

2014-01-01

Graphics processing units are increasingly being used for scientific computing for their powerful parallel processing abilities, and moderate price compared to super computers and computing grids. In this paper we have used a general purpose graphics processing unit to process adaptive-optics optical coherence tomography (AOOCT) images in real time. Increasing the processing speed of AOOCT is an essential step in moving the super high resolution technology closer to clinical viability.

LASER BIOLOGY AND MEDICINE: Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes

NASA Astrophysics Data System (ADS)

Kuranov, R. V.; Sapozhnikova, V. V.; Shakhova, N. M.; Gelikonov, V. M.; Zagainova, E. V.; Petrova, S. A.

2002-11-01

A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and scar changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma of the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm.

Optical cryptography topology based on a three-dimensional particle-like distribution and diffractive imaging.

PubMed

Chen, Wen; Chen, Xudong

2011-05-09

In recent years, coherent diffractive imaging has been considered as a promising alternative for information retrieval instead of conventional interference methods. Coherent diffractive imaging using the X-ray light source has opened up a new research perspective for the measurement of non-crystalline and biological specimens, and can achieve unprecedentedly high resolutions. In this paper, we show how a three-dimensional (3D) particle-like distribution and coherent diffractive imaging can be applied for a study of optical cryptography. An optical multiple-random-phase-mask encoding approach is used, and the plaintext is considered as a series of particles distributed in a 3D space. A topology concept is also introduced into the proposed optical cryptosystem. During image decryption, a retrieval algorithm is developed to extract the plaintext from the ciphertexts. In addition, security and advantages of the proposed optical cryptography topology are also analyzed. © 2011 Optical Society of America

Optical characterization in wide spectral range by a coherent spectrophotometer

NASA Astrophysics Data System (ADS)

Sirutkaitis, Valdas; Eckardt, Robert C.; Balachninaite, Ona; Grigonis, Rimantas; Melninkaitis, A.; Rakickas, T.

2003-11-01

We report on the development and use of coherent spectrophotometers specialized for the unusual requirements of characterizing nonlinear optical materials and multilayer dielectric coatings used in laser systems. A large dynamic range is required to measure the linear properties of transmission, reflection and absorption and nonlinear properties of laser-induced damage threshold and nonlinear frequency conversion. Optical parametric oscillators generate coherent radiation that is widely tunable with instantaneous powers that can range from milliwatts to megawatts and are well matched to this application. As particular example a laser spectrophotometer based on optical parametric oscillators and a diode-pumped, Q-switched Nd:YAG laser and suitable for optical characterization in the spectral range 420-4500 nm is described. Measurements include reflectance and transmittance, absorption, scattering and laser-induced damage thresholds. Possibilities of a system based on a 130-fs Ti:sapphire laser and optical parametric generators are also discussed.

Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuranov, R V; Sapozhnikova, V V; Shakhova, N M

2002-11-30

A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and scar changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma ofmore » the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm. (laser biology and medicine)« less

High-speed spectral domain polarization- sensitive optical coherence tomography using a single camera and an optical switch at 1.3 microm.

PubMed

Lee, Sang-Won; Jeong, Hyun-Woo; Kim, Beop-Min

2010-01-01

We propose high-speed spectral domain polarization-sensitive optical coherence tomography (SD-PS-OCT) using a single camera and a 1x2 optical switch at the 1.3-microm region. The PS-low coherence interferometer used in the system is constructed using free-space optics. The reflected horizontal and vertical polarization light rays are delivered via an optical switch to a single spectrometer by turns. Therefore, our system costs less to build than those that use dual spectrometers, and the processes of timing and triggering are simpler from the viewpoints of both hardware and software. Our SD-PS-OCT has a sensitivity of 101.5 dB, an axial resolution of 8.2 microm, and an acquisition speed of 23,496 A-scans per second. We obtain the intensity, phase retardation, and fast axis orientation images of a rat tail tendon ex vivo.

Dosimetry control and monitoring of selective retina therapy using optical coherence tomography

NASA Astrophysics Data System (ADS)

Kaufmann, Daniel; Burri, Christian; Arnold, Patrik; Koch, Volker M.; Meier, Christoph; Považay, Boris; Justiz, Joern

2017-07-01

Selective retina therapy and optical coherence tomography have been combined to monitor laser-tissue interaction in real-time. An ex-vivo study of porcine eyes unveils mechanisms that enable automated and accurate dose-control during laser-therapy.

Light field measurement based on the single-lens coherent diffraction imaging

NASA Astrophysics Data System (ADS)

Shen, Cheng; Tan, Jiubin; Liu, Zhengjun

2018-01-01

Plenoptic camera and holography are popular light field measurement techniques. However, the low resolution or the complex apparatus hinders their widespread application. In this paper, we put forward a new light field measurement scheme. The lens is introduced into coherent diffraction imaging to operate an optical transform, extended fractional Fourier transform. Combined with the multi-image phase retrieval algorithm, the scheme is proved to hold several advantages. It gets rid of the support requirement and is much easier to implement while keeping a high resolution by making full use of the detector plane. Also, it is verified that our scheme has a superiority over the direct lens focusing imaging in amplitude measurement accuracy and phase retrieval ability.

Polarization sensitive optical low-coherence reflectometry for blood glucose monitoring in human subjects

NASA Astrophysics Data System (ADS)

Solanki, Jitendra; Choudhary, Om Prakash; Sen, P.; Andrews, J. T.

2013-07-01

A device based on polarization sensitive optical low-coherence reflectometry is developed to monitor blood glucose levels in human subjects. The device was initially tested with tissue phantom. The measurements with human subjects for various glucose concentration levels are found to be linearly dependent on the ellipticity obtainable from the home-made phase-sensitive optical low-coherence reflectometry device. The linearity obtained between glucose concentration and ellipticity are explained with theoretical calculations using Mie theory. A comparison of results with standard clinical methods establishes the utility of the present device for non-invasive glucose monitoring.

Optical coherence tomography findings of bilateral foveal leukemic infiltration

PubMed Central

Le, John Q; Braich, Puneet S; Brar, Vikram S

2016-01-01

We report a case of a 59-year-old man with a history of atypical chronic myelogenous leukemia who presented with a several-week history of decreased vision in both eyes. His clinical examination revealed bilateral foveal infiltration, which was also demonstrated on optical coherence tomography. After a failed induction with imatinib (Gleevec®), he was treated with omacetaxine (Synribo®) with an appropriate hematologic response. As his leukemia improved with chemotherapy, his retinal lesions regressed as demonstrated by serial optical coherence tomography and fundus photographs, with near complete restoration of foveal architecture. PMID:27540313

Enhancement of the resolution of full-field optical coherence tomography by using a colour image sensor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalyanov, A L; Lychagov, V V; Smirnov, I V

2013-08-31

The influence of white balance in a colour image detector on the resolution of a full-field optical coherence tomograph (FFOCT) is studied. The change in the interference pulse width depending on the white balance tuning is estimated in the cases of a thermal radiation source (incandescent lamp) and a white light emitting diode. It is shown that by tuning white balance of the detector in a certain range, the FFOCT resolution can be increased by 20 % as compared to the resolution, attained with the use of a monochrome detector. (optical coherence tomography)

IN VIVO CHARACTERIZATION OF ORAL PEMPHIGUS VULGARIS BY OPTICAL COHERENCE TOMOGRAPHY.

PubMed

Di Stasio, D; Lauritano, D; Romano, A; Salerno, C; Minervini, G; Minervini, G; Gentile, E; Serpico, R; Lucchese, A

2015-01-01

Pemphigus vulgaris (PV) is an autoimmune disease that manifests as intraepithelial blisters in skin and mucous membranes. We report the case of a 62-year-old female patient with clinical picture of desquamative gingivitis and a histological and serological diagnosis of pemphigus vulgaris. The aim of this study is to analyse bollous oral diseases in order to evaluate the feasibility to image epithelial architecture of oral mucosae using in vivo optical coherence tomography. Optical coherence tomography seems to be a valid non-invasive auxiliary diagnostic device able to show in vivo the epithelial layers and basal membrane.

Digital phase demodulation for low-coherence interferometry-based fiber-optic sensors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Y.; Strum, R.; Stiles, D.

In this paper, we describe a digital phase demodulation scheme for low-coherence interferometry-based fiber-optic sensors by employing a simple generation of phase-shifted signals at the interrogation interferometer. The scheme allows a real-time calibration process and offers capability of measuring large variations (up to the coherence of the light source) at the bandwidth that is only limited by the data acquisition system. Finally, the proposed phase demodulation method is analytically derived and its validity and performance are experimentally verified using fiber-optic Fabry–Perot sensors for measurement of strains and vibrations.

Digital phase demodulation for low-coherence interferometry-based fiber-optic sensors

DOE PAGES

Liu, Y.; Strum, R.; Stiles, D.; ...

2017-11-20

In this paper, we describe a digital phase demodulation scheme for low-coherence interferometry-based fiber-optic sensors by employing a simple generation of phase-shifted signals at the interrogation interferometer. The scheme allows a real-time calibration process and offers capability of measuring large variations (up to the coherence of the light source) at the bandwidth that is only limited by the data acquisition system. Finally, the proposed phase demodulation method is analytically derived and its validity and performance are experimentally verified using fiber-optic Fabry–Perot sensors for measurement of strains and vibrations.

Ultrafast Coherent Dynamics of a Photonic Crystal All-Optical Switch.

PubMed

Colman, Pierre; Lunnemann, Per; Yu, Yi; Mørk, Jesper

2016-12-02

We present pump-probe measurements of an all-optical photonic crystal switch based on a nanocavity, resolving fast coherent temporal dynamics. The measurements demonstrate the importance of coherent effects typically neglected when considering nanocavity dynamics. In particular, we report the observation of an idler pulse and more than 10 dB parametric gain. The measurements are in good agreement with a theoretical model that ascribes the observation to oscillations of the free-carrier population in the nanocavity. The effect opens perspectives for the realization of new all-optical photonic crystal switches with unprecedented switching contrast.

Spontaneous closure of macular hole in a patient with x-linked juvenile retinoschisis.

PubMed

Gao, Hua; Province, William D; Peracha, Mohammed O

2010-01-01

To observe macular hole in a patient with juvenile retinoschisis. A 4-year-old boy with X-linked juvenile retinoschisis was examined and followed-up for 2 years. Optical coherence tomography was used to study his maculae. A full-thickness macular hole was detected by clinical examination and optical coherence tomography. Spontaneous closure of the macular hole was noticed and confirmed by optical coherence tomography 2 years later with visual improvement. Macular hole in patients with juvenile retinoschisis should be observed for at least a short period of time before a surgical repair is considered.

Fundus autofluorescence, optical coherence tomography, and electroretinogram findings in choroidal sclerosis.

PubMed

Hwang, John C; Kim, David Y; Chou, Chai Lin; Tsang, Stephen H

2010-01-01

The purpose of this study was to describe fundus autofluorescence (FAF), optical coherence tomography, and electroretinogram findings in choroidal sclerosis. This is a retrospective case series. Eight eyes of four patients with choroidal sclerosis were evaluated with FAF, optical coherence tomography, and electroretinogram testing. In all eight eyes, FAF imaging showed hypofluorescent placoid lesions corresponding to areas of chorioretinal atrophy seen on stereo biomicroscopy. Prominent hyperfluorescent linear markings underlying regions of atrophic disease were observed in all eyes, likely representative of normal choroidal vessel autofluorescence. In two eyes, FAF showed punctate hypofluorescent lesions in the fovea that were not visualized on biomicroscopy. In one eye, FAF identified a central island of preserved retinal pigment epithelium that was not realized on ophthalmoscopic examination. Optical coherence imaging was significant for loss of choroidal fine tubular structures, retinal pigment epithelium, and outer nuclear layer in regions of chorioretinal atrophy. Full-field electroretinogram testing showed generalized rod-cone dysfunction in all patients with a lower B- to A-wave ratio in two patients. Fundus autofluorescence and optical coherence tomography are nonin-vasive diagnostic adjuncts that can aid in the diagnosis of choroidal sclerosis. Fundus autofluorescence may be a more sensitive marker of disease extent and progression than clinical examination alone. Electroretinogram testing can result in an electronegative maximal response.

Quantum coherent optical phase modulation in an ultrafast transmission electron microscope.

PubMed

Feist, Armin; Echternkamp, Katharina E; Schauss, Jakob; Yalunin, Sergey V; Schäfer, Sascha; Ropers, Claus

2015-05-14

Coherent manipulation of quantum systems with light is expected to be a cornerstone of future information and communication technology, including quantum computation and cryptography. The transfer of an optical phase onto a quantum wavefunction is a defining aspect of coherent interactions and forms the basis of quantum state preparation, synchronization and metrology. Light-phase-modulated electron states near atoms and molecules are essential for the techniques of attosecond science, including the generation of extreme-ultraviolet pulses and orbital tomography. In contrast, the quantum-coherent phase-modulation of energetic free-electron beams has not been demonstrated, although it promises direct access to ultrafast imaging and spectroscopy with tailored electron pulses on the attosecond scale. Here we demonstrate the coherent quantum state manipulation of free-electron populations in an electron microscope beam. We employ the interaction of ultrashort electron pulses with optical near-fields to induce Rabi oscillations in the populations of electron momentum states, observed as a function of the optical driving field. Excellent agreement with the scaling of an equal-Rabi multilevel quantum ladder is obtained, representing the observation of a light-driven 'quantum walk' coherently reshaping electron density in momentum space. We note that, after the interaction, the optically generated superposition of momentum states evolves into a train of attosecond electron pulses. Our results reveal the potential of quantum control for the precision structuring of electron densities, with possible applications ranging from ultrafast electron spectroscopy and microscopy to accelerator science and free-electron lasers.

Quantum coherent optical phase modulation in an ultrafast transmission electron microscope

NASA Astrophysics Data System (ADS)

Feist, Armin; Echternkamp, Katharina E.; Schauss, Jakob; Yalunin, Sergey V.; Schäfer, Sascha; Ropers, Claus

2015-05-01

Coherent manipulation of quantum systems with light is expected to be a cornerstone of future information and communication technology, including quantum computation and cryptography. The transfer of an optical phase onto a quantum wavefunction is a defining aspect of coherent interactions and forms the basis of quantum state preparation, synchronization and metrology. Light-phase-modulated electron states near atoms and molecules are essential for the techniques of attosecond science, including the generation of extreme-ultraviolet pulses and orbital tomography. In contrast, the quantum-coherent phase-modulation of energetic free-electron beams has not been demonstrated, although it promises direct access to ultrafast imaging and spectroscopy with tailored electron pulses on the attosecond scale. Here we demonstrate the coherent quantum state manipulation of free-electron populations in an electron microscope beam. We employ the interaction of ultrashort electron pulses with optical near-fields to induce Rabi oscillations in the populations of electron momentum states, observed as a function of the optical driving field. Excellent agreement with the scaling of an equal-Rabi multilevel quantum ladder is obtained, representing the observation of a light-driven `quantum walk' coherently reshaping electron density in momentum space. We note that, after the interaction, the optically generated superposition of momentum states evolves into a train of attosecond electron pulses. Our results reveal the potential of quantum control for the precision structuring of electron densities, with possible applications ranging from ultrafast electron spectroscopy and microscopy to accelerator science and free-electron lasers.

Continuum generation in optical fibers for high-resolution holographic coherence domain imaging application

NASA Astrophysics Data System (ADS)

Li, Linghui; Gruzdev, Vitaly; Yu, Ping; Chen, J. K.

2009-02-01

High pulse energy continuum generation in conventional multimode optical fibers has been studied for potential applications to a holographic optical coherence imaging system. As a new imaging modality for the biological tissue imaging, high-resolution holographic optical coherence imaging requires a broadband light source with a high brightness, a relatively low spatial coherence and a high stability. A broadband femtosecond laser can not be used as the light source of holographic imaging system since the laser creates a lot of speckle patterns. By coupling high peak power femtosecond laser pulses into a multimode optical fiber, nonlinear optical effects cause a continuum generation that can be served as a super-bright and broadband light source. In our experiment, an amplified femtosecond laser was coupled into the fiber through a microscopic objective. We measured the FWHM of the continuum generation as a function of incident pulse energy from 80 nJ to 800 μJ. The maximum FWHM is about 8 times higher than that of the input pulses. The stability was analyzed at different pump energies, integration times and fiber lengths. The spectral broadening and peak position show that more than two processes compete in the fiber.

Coherent noise reduction in digital holographic microscopy by averaging multiple holograms recorded with a multimode laser.

PubMed

Pan, Feng; Yang, Lizhi; Xiao, Wen

2017-09-04

In digital holographic microscopy (DHM), it is undesirable to observe coherent noise in the reconstructed images. The sources of the noise are mainly the parasitic interference fringes caused by multiple reflections and the speckle pattern caused by the optical scattering on the object surface. Here we propose a noise reduction approach in DHM by averaging multiple holograms recorded with a multimode laser. Based on the periodicity of the temporal coherence of a multimode semiconductor laser, we acquire a series of holograms by changing the optical path length difference between the reference beam and object beam. Because of the use of low coherence light, we can remove the parasitic interference fringes caused by multiple reflections in the holograms. In addition, the coherent noise patterns change in this process due to the different optical paths. Therefore, the coherent noise can be reduced by averaging the multiple reconstructions with uncorrelated noise patterns. Several experiments have been carried out to validate the effectiveness of the proposed approach for coherent noise reduction in DHM. It is shown a remarkable improvement both in amplitude imaging quality and phase measurement accuracy.

Simultaneous measurement of refractive index and thickness by combining low-coherence interferometry and confocal optics.

PubMed

Kim, Seokhan; Na, Jihoon; Kim, Myoung Jin; Lee, Byeong Ha

2008-04-14

We propose and demonstrate novel methods that enable simultaneous measurements of the phase index, the group index, and the geometrical thickness of an optically transparent object by combining optical low-coherence interferometer and confocal optics. The low-coherence interferometer gives information relating the group index with the thickness, while the confocal optics allows access to the phase index related with the thickness of the sample. To relate these, two novel methods were devised. In the first method, the dispersion-induced broadening of the low-coherence envelop signal was utilized, and in the second method the frequency derivative of the phase index was directly obtained by taking the confocal measurements at several wavelengths. The measurements were made with eight different samples; B270, CaF2, two of BK7, two of fused silica, cover glass, and cigarette cover film. The average measurement errors of the first and the second methods were 0.123% and 0.061% in the geometrical thickness, 0.133% and 0.066% in the phase index, and 0.106% and 0.057% in the group index, respectively.

Coherent spin control of a nanocavity-enhanced qubit in diamond

DOE PAGES

Li, Luozhou; Lu, Ming; Schroder, Tim; ...

2015-01-28

A central aim of quantum information processing is the efficient entanglement of multiple stationary quantum memories via photons. Among solid-state systems, the nitrogen-vacancy centre in diamond has emerged as an excellent optically addressable memory with second-scale electron spin coherence times. Recently, quantum entanglement and teleportation have been shown between two nitrogen-vacancy memories, but scaling to larger networks requires more efficient spin-photon interfaces such as optical resonators. Here we report such nitrogen-vacancy nanocavity systems in strong Purcell regime with optical quality factors approaching 10,000 and electron spin coherence times exceeding 200 µs using a silicon hard-mask fabrication process. This spin-photon interfacemore » is integrated with on-chip microwave striplines for coherent spin control, providing an efficient quantum memory for quantum networks.« less

Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

PubMed Central

Ughi, Giovanni J.; Gora, Michalina J.; Swager, Anne-Fré; Soomro, Amna; Grant, Catriona; Tiernan, Aubrey; Rosenberg, Mireille; Sauk, Jenny S.; Nishioka, Norman S.; Tearney, Guillermo J.

2016-01-01

Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure of the esophagus, including Barrett’s esophagus (BE) and associated dysplasia. We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires high-resolution images of entire gastrointestinal (GI) tract luminal organs. This device has a potential to become a screening method that identifies patients with an abnormal esophagus that should be further referred for upper endoscopy. Currently, the characterization of the OCT-TCE esophageal wall data set is performed manually, which is time-consuming and inefficient. Additionally, since the capsule optics optimally focus light approximately 500 µm outside the capsule wall and the best quality images are obtained when the tissue is in full contact with the capsule, it is crucial to provide feedback for the operator about tissue contact during the imaging procedure. In this study, we developed a fully automated algorithm for the segmentation of in vivo OCT-TCE data sets and characterization of the esophageal wall. The algorithm provides a two-dimensional representation of both the contact map from the data collected in human clinical studies as well as a tissue map depicting areas of BE with or without dysplasia. Results suggest that these techniques can potentially improve the current TCE data acquisition procedure and provide an efficient characterization of the diseased esophageal wall. PMID:26977350

Frequency accurate coherent electro-optic dual-comb spectroscopy in real-time.

PubMed

Martín-Mateos, Pedro; Jerez, Borja; Largo-Izquierdo, Pedro; Acedo, Pablo

2018-04-16

Electro-optic dual-comb spectrometers have proved to be a promising technology for sensitive, high-resolution and rapid spectral measurements. Electro-optic combs possess very attractive features like simplicity, reliability, bright optical teeth, and typically moderate but quickly tunable optical spans. Furthermore, in a dual-comb arrangement, narrowband electro-optic combs are generated with a level of mutual coherence that is sufficiently high to enable optical multiheterodyning without inter-comb stabilization or signal processing systems. However, this valuable tool still presents several limitations; for instance, on most systems, absolute frequency accuracy and long-term stability cannot be guaranteed; likewise, interferometer-induced phase noise restricts coherence time and limits the attainable signal-to-noise ratio. In this paper, we address these drawbacks and demonstrate a cost-efficient absolute electro-optic dual-comb instrument based on a frequency stabilization mechanism and a novel adaptive interferogram acquisition approach devised for electro-optic dual-combs capable of operating in real-time. The spectrometer, completely built from commercial components, provides sub-ppm frequency uncertainties and enables a signal-to-noise ratio of 10000 (intensity noise) in 30 seconds of integration time.

Advanced polarization sensitive analysis in optical coherence tomography

NASA Astrophysics Data System (ADS)

Wieloszyńska, Aleksandra; StrÄ kowski, Marcin R.

2017-08-01

The optical coherence tomography (OCT) is an optical imaging method, which is widely applied in variety applications. This technology is used to cross-sectional or surface imaging with high resolution in non-contact and non-destructive way. OCT is very useful in medical applications like ophthalmology, dermatology or dentistry, as well as beyond biomedical fields like stress mapping in polymers or protective coatings defects detection. Standard OCT imaging is based on intensity images which can visualize the inner structure of scattering devices. However, there is a number of extensions improving the OCT measurement abilities. The main of them are the polarization sensitive OCT (PS-OCT), Doppler enable OCT (D-OCT) or spectroscopic OCT (S-OCT). Our research activities have been focused on PS-OCT systems. The polarization sensitive analysis delivers an useful information about optical anisotropic properties of the evaluated sample. This kind of measurements is very important for inner stress monitoring or e.g. tissue recognition. Based on our research results and knowledge the standard PS-OCT provide only data about birefringence of the measured sample. However, based on the OCT measurements more information including depolarization and diattenuation might be obtained. In our work, the method based on Jones formalism are going to be presented. It is used to determine birefringence, dichroism and optic axis orientation of the tested sample. In this contribution the setup of the optical system, as well as tests results verifying the measurements abilities of the system are going to be presented. The brief discussion about the effectiveness and usefulness of this approach will be carried out.

A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

PubMed Central

Jonnal, Ravi S.; Kocaoglu, Omer P.; Zawadzki, Robert J.; Liu, Zhuolin; Miller, Donald T.; Werner, John S.

2016-01-01

Purpose Optical coherence tomography (OCT) has enabled “virtual biopsy” of the living human retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here, we review work done over the last 15 years to combine the microscopic transverse resolution of AO with the microscopic axial resolution of OCT, building AO-OCT systems with the highest three-dimensional resolution of any existing retinal imaging modality. Methods We surveyed the literature to identify the most influential antecedent work, important milestones in the development of AO-OCT technology, its applications that have yielded new knowledge, research areas into which it may productively expand, and nascent applications that have the potential to grow. Results Initial efforts focused on demonstrating three-dimensional resolution. Since then, many improvements have been made in resolution and speed, as well as other enhancements of acquisition and postprocessing techniques. Progress on these fronts has produced numerous discoveries about the anatomy, function, and optical properties of the retina. Conclusions Adaptive optics OCT continues to evolve technically and to contribute to our basic and clinical knowledge of the retina. Due to its capacity to reveal cellular and microscopic detail invisible to clinical OCT systems, it is an ideal companion to those instruments and has the demonstrable potential to produce images that can guide the interpretation of clinical findings. PMID:27409507

Design and performance evaluation of an OpenFlow-based control plane for software-defined elastic optical networks with direct-detection optical OFDM (DDO-OFDM) transmission.

PubMed

Liu, Lei; Peng, Wei-Ren; Casellas, Ramon; Tsuritani, Takehiro; Morita, Itsuro; Martínez, Ricardo; Muñoz, Raül; Yoo, S J B

2014-01-13

Optical Orthogonal Frequency Division Multiplexing (O-OFDM), which transmits high speed optical signals using multiple spectrally overlapped lower-speed subcarriers, is a promising candidate for supporting future elastic optical networks. In contrast to previous works which focus on Coherent Optical OFDM (CO-OFDM), in this paper, we consider the direct-detection optical OFDM (DDO-OFDM) as the transport technique, which leads to simpler hardware and software realizations, potentially offering a low-cost solution for elastic optical networks, especially in metro networks, and short or medium distance core networks. Based on this network scenario, we design and deploy a software-defined networking (SDN) control plane enabled by extending OpenFlow, detailing the network architecture, the routing and spectrum assignment algorithm, OpenFlow protocol extensions and the experimental validation. To the best of our knowledge, it is the first time that an OpenFlow-based control plane is reported and its performance is quantitatively measured in an elastic optical network with DDO-OFDM transmission.

Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma.

PubMed

Pierro, Luisa; Marchese, Alessandro; Gagliardi, Marco; Bandello, Francesco

2017-08-01

Retinal cavernous hemangioma is a rare, benign, retinal tumor characterized by angiomatous proliferation of vessels within the inner retina or the optic disc.1 Here we report a case of retinal cavernous hemangioma on the margin of the optic disc in the right eye of a 61-year-old asymptomatic female. The lesion was studied with multimodal imaging which included structural optical coherence tomography, fluorescein angiography, blue fundus auto-fluorescence, optical coherence tomography angiography (OCTA) (DRI OCT Triton; Topcon, Tokyo, Japan) and visual field examination. Blood circulation inside retinal cavernous hemangioma lesion is typically low-stagnant.2 However, OCTA demonstrated blood flow inside the lesion, illustrating its vascular circulation.3 Visual field was within the normal limits, except from a slight enlargement of the blind spot. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:684-685.]. Copyright 2017, SLACK Incorporated.

Development of a coherent optical particle spectrometer for industrial applications: a feasibility investigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, H.T.; Bachalo, W.D.

1984-10-01

The feasibility of developing a particle-sizing instrument for in-situ measurements in industrial environments, based on the method of optical heterodyne or coherent detection, was investigated. The instrument, a coherent optical particle spectrometer, or COPS, is potentially capable of measuring several important particle parameters, such as particle size, number density, and speed, because of the versatility of the optical heterodyne method. Water droplets generated by an aerosol/particle generator were used to test the performance of the COPS. Study findings have shown that the optical setup of the COPS is extremely sensitive to even minute mechanical or acoustic vibrations. At the optimalmore » setup, the COPS performs satisfactorily and has more than adequate signal-to-noise even with a 0.5 mW He-Ne laser.« less

Computation of tightly-focused laser beams in the FDTD method

PubMed Central

Çapoğlu, İlker R.; Taflove, Allen; Backman, Vadim

2013-01-01

We demonstrate how a tightly-focused coherent TEMmn laser beam can be computed in the finite-difference time-domain (FDTD) method. The electromagnetic field around the focus is decomposed into a plane-wave spectrum, and approximated by a finite number of plane waves injected into the FDTD grid using the total-field/scattered-field (TF/SF) method. We provide an error analysis, and guidelines for the discrete approximation. We analyze the scattering of the beam from layered spaces and individual scatterers. The described method should be useful for the simulation of confocal microscopy and optical data storage. An implementation of the method can be found in our free and open source FDTD software (“Angora”). PMID:23388899

Computation of tightly-focused laser beams in the FDTD method.

PubMed

Capoğlu, Ilker R; Taflove, Allen; Backman, Vadim

2013-01-14

We demonstrate how a tightly-focused coherent TEMmn laser beam can be computed in the finite-difference time-domain (FDTD) method. The electromagnetic field around the focus is decomposed into a plane-wave spectrum, and approximated by a finite number of plane waves injected into the FDTD grid using the total-field/scattered-field (TF/SF) method. We provide an error analysis, and guidelines for the discrete approximation. We analyze the scattering of the beam from layered spaces and individual scatterers. The described method should be useful for the simulation of confocal microscopy and optical data storage. An implementation of the method can be found in our free and open source FDTD software ("Angora").

Ultrafast acousto-optic mode conversion in optically birefringent ferroelectrics

PubMed Central

Lejman, Mariusz; Vaudel, Gwenaelle; Infante, Ingrid C.; Chaban, Ievgeniia; Pezeril, Thomas; Edely, Mathieu; Nataf, Guillaume F.; Guennou, Mael; Kreisel, Jens; Gusev, Vitalyi E.; Dkhil, Brahim; Ruello, Pascal

2016-01-01

The ability to generate efficient giga–terahertz coherent acoustic phonons with femtosecond laser makes acousto-optics a promising candidate for ultrafast light processing, which faces electronic device limits intrinsic to complementary metal oxide semiconductor technology. Modern acousto-optic devices, including optical mode conversion process between ordinary and extraordinary light waves (and vice versa), remain limited to the megahertz range. Here, using coherent acoustic waves generated at tens of gigahertz frequency by a femtosecond laser pulse, we reveal the mode conversion process and show its efficiency in ferroelectric materials such as BiFeO3 and LiNbO3. Further to the experimental evidence, we provide a complete theoretical support to this all-optical ultrafast mechanism mediated by acousto-optic interaction. By allowing the manipulation of light polarization with gigahertz coherent acoustic phonons, our results provide a novel route for the development of next-generation photonic-based devices and highlight new capabilities in using ferroelectrics in modern photonics. PMID:27492493

Coherent multi-dimensional spectroscopy at optical frequencies in a single beam with optical readout

NASA Astrophysics Data System (ADS)

Seiler, Hélène; Palato, Samuel; Kambhampati, Patanjali

2017-09-01

Ultrafast coherent multi-dimensional spectroscopies form a powerful set of techniques to unravel complex processes, ranging from light-harvesting, chemical exchange in biological systems to many-body interactions in quantum-confined materials. Yet these spectroscopies remain complex to implement at the high frequencies of vibrational and electronic transitions, thereby limiting their widespread use. Here we demonstrate the feasibility of two-dimensional spectroscopy at optical frequencies in a single beam. Femtosecond optical pulses are spectrally broadened to a relevant bandwidth and subsequently shaped into phase coherent pulse trains. By suitably modulating the phases of the pulses within the beam, we show that it is possible to directly read out the relevant optical signals. This work shows that one needs neither complex beam geometries nor complex detection schemes in order to measure two-dimensional spectra at optical frequencies. Our setup provides not only a simplified experimental design over standard two-dimensional spectrometers but its optical readout also enables novel applications in microscopy.

Optically Tunable Gratings Based on Coherent Population Oscillation.

PubMed

Zhang, Xiao-Jun; Wang, Hai-Hua; Wang, Lei; Wu, Jin-Hui

2018-05-01

We theoretically study the optically tunable gratings based on a L-type atomic medium using coherent population oscillations from the angle of reflection and transmission of the probe field. Adopting a standing-wave driving field, the refractive index of the medium as well as the absorption are periodically modified. Consequently, the Bragg scattering causes the effective reflection. We show that different intensities of the control field lead to three types of reflection profile which actually correspond to different absorption/amplification features of the medium. We present a detailed analyses about the influence of amplification on the reflection profile as well. The coherent population oscillation is robust to the dephasing effect, and such induced gratings could have promising applications in nonlinear optics and all-optical information processing.

Coherent transfer of orbital angular momentum to excitons by optical four-wave mixing.

PubMed

Ueno, Y; Toda, Y; Adachi, S; Morita, R; Tawara, T

2009-10-26

We demonstrate the coherent transfer of optical orbital angular momentum (OAM) to the center of mass momentum of excitons in semiconductor GaN using a four-wave mixing (FWM) process. When we apply the optical vortex (OV) as an excitation pulse, the diffracted FWM signal exhibits phase singularities that satisfy the OAM conservation law, which remain clear within the exciton dephasing time (approximately 1ps). We also demonstrate the arbitrary control of the topological charge in the output signal by changing the OAM of the input pulse. The results provide a way of controlling the optical OAM through carriers in solids. Moreover, the time evolution of the FWM with OAM leads to the study of the closed-loop carrier coherence in materials.

Coherent Pound-Drever-Hall technique for high resolution fiber optic strain sensor at very low light power

NASA Astrophysics Data System (ADS)

Wu, Mengxin; Liu, Qingwen; Chen, Jiageng; He, Zuyuan

2017-04-01

Pound-Drever-Hall (PDH) technique has been widely adopted for ultrahigh resolution fiber-optic sensors, but its performance degenerates seriously as the light power drops. To solve this problem, we developed a coherent PDH technique for weak optical signal detection, with which the signal-to-noise ratio (SNR) of demodulated PDH signal is dramatically improved. In the demonstrational experiments, a high resolution fiber-optic sensor using the proposed technique is realized, and n"-order strain resolution at a low light power down to -43 dBm is achieved, which is about 15 dB lower compared with classical PDH technique. The proposed coherent PDH technique has great potentials in longer distance and larger scale sensor networks.

Optical Coherence Tomography of the Tympanic Membrane and Middle Ear: A Review.

PubMed

Tan, Hsern Ern Ivan; Santa Maria, Peter Luke; Wijesinghe, Philip; Francis Kennedy, Brendan; Allardyce, Benjamin James; Eikelboom, Robert Henry; Atlas, Marcus David; Dilley, Rodney James

2018-05-01

Objective To evaluate the recent developments in optical coherence tomography (OCT) for tympanic membrane (TM) and middle ear (ME) imaging and to identify what further development is required for the technology to be integrated into common clinical use. Data Sources PubMed, Embase, Google Scholar, Scopus, and Web of Science. Review Methods A comprehensive literature search was performed for English language articles published from January 1966 to January 2018 with the keywords "tympanic membrane or middle ear,"optical coherence tomography," and "imaging." Conclusion Conventional imaging techniques cannot adequately resolve the microscale features of TM and ME, sometimes necessitating diagnostic exploratory surgery in challenging otologic pathology. As a high-resolution noninvasive imaging technique, OCT offers promise as a diagnostic aid for otologic conditions, such as otitis media, cholesteatoma, and conductive hearing loss. Using OCT vibrometry to image the nanoscale vibrations of the TM and ME as they conduct acoustic waves may detect the location of ossicular chain dysfunction and differentiate between stapes fixation and incus-stapes discontinuity. The capacity of OCT to image depth and thickness at high resolution allows 3-dimensional volumetric reconstruction of the ME and has potential use for reconstructive tympanoplasty planning and the follow-up of ossicular prostheses. Implications for Practice To achieve common clinical use beyond these initial discoveries, future in vivo imaging devices must feature low-cost probe or endoscopic designs and faster imaging speeds and demonstrate superior diagnostic utility to computed tomography and magnetic resonance imaging. While such technology has been available for OCT, its translation requires focused development through a close collaboration between engineers and clinicians.

Dynamic phase-sensitive optical coherence elastography at a true kilohertz frame-rate

NASA Astrophysics Data System (ADS)

Singh, Manmohan; Wu, Chen; Liu, Chih-Hao; Li, Jiasong; Schill, Alexander; Nair, Achuth; Larin, Kirill V.

2016-03-01

Dynamic optical coherence elastography (OCE) techniques have rapidly emerged as a noninvasive way to characterize the biomechanical properties of tissue. However, clinical applications of the majority of these techniques have been unfeasible due to the extended acquisition time because of multiple temporal OCT acquisitions (M-B mode). Moreover, multiple excitations, large datasets, and prolonged laser exposure prohibit their translation to the clinic, where patient discomfort and safety are critical criteria. Here, we demonstrate the feasibility of noncontact true kilohertz frame-rate dynamic optical coherence elastography by directly imaging a focused air-pulse induced elastic wave with a home-built phase-sensitive OCE system. The OCE system was based on a 4X buffered Fourier Domain Mode Locked swept source laser with an A-scan rate of ~1.5 MHz, and imaged the elastic wave propagation at a frame rate of ~7.3 kHz. Because the elastic wave directly imaged, only a single excitation was utilized for one line scan measurement. Rather than acquiring multiple temporal scans at successive spatial locations as with previous techniques, here, successive B-scans were acquired over the measurement region (B-M mode). Preliminary measurements were taken on tissue-mimicking agar phantoms of various concentrations, and the results showed good agreement with uniaxial mechanical compression testing. Then, the elasticity of an in situ porcine cornea in the whole eye-globe configuration at various intraocular pressures was measured. The results showed that this technique can acquire a depth-resolved elastogram in milliseconds. Furthermore, the ultra-fast acquisition ensured that the laser safety exposure limit for the cornea was not exceeded.

Comment on "Optical-fiber-based Mueller optical coherence tomography".

PubMed

Park, B Hyle; Pierce, Mark C; de Boer, Johannes F

2004-12-15

We comment on the recent Letter by Jiao et al. [Opt. Lett. 28, 1206 (2003)] in which a polarization-sensitive optical coherence tomography system was presented. Interrogating a sample with two orthogonal incident polarization states cannot always recover birefringence correctly. A previously presented fiber-based polarization-sensitive system was inaccurately characterized, and its method of eliminating the polarization distortion caused by single-mode optical fiber was presented earlier by Saxer et al. [Opt. Lett. 25, 1355 (2000)].

Super-luminescent jet light generated by femtosecond laser pulses

PubMed Central

Xu, Zhijun; Zhu, Xiaonong; Yu, Yang; Zhang, Nan; Zhao, Jiefeng

2014-01-01

Phenomena of nonlinear light-matter interaction that occur during the propagation of intense ultrashort laser pulses in continuous media have been extensively studied in ultrafast optical science. In this vibrant research field, conversion of the input laser beam into optical filament(s) is commonly encountered. Here, we demonstrate generation of distinctive single or double super-luminescent optical jet beams as a result of strong spatial-temporal nonlinear interaction between focused 50 fs millijoule laser pulses and their induced micro air plasma. Such jet-like optical beams, being slightly divergent and coexisting with severely distorted conical emission of colored speckles, are largely different from optical filaments, and obtainable when the focal lens of proper f-number is slightly tilted or shifted. Once being collimated, the jet beams can propagate over a long distance in air. These beams not only reveal a potentially useful approach to coherent optical wave generation, but also may find applications in remote sensing. PMID:24463611

Image routing via atomic spin coherence

PubMed Central

Wang, Lei; Sun, Jia-Xiang; Luo, Meng-Xi; Sun, Yuan-Hang; Wang, Xiao-Xiao; Chen, Yi; Kang, Zhi-Hui; Wang, Hai-Hua; Wu, Jin-Hui; Gao, Jin-Yue

2015-01-01

Coherent storage of optical image in a coherently-driven medium is a promising method with possible applications in many fields. In this work, we experimentally report a controllable spatial-frequency routing of image via atomic spin coherence in a solid-state medium driven by electromagnetically induced transparency (EIT). Under the EIT-based light-storage regime, a transverse spatial image carried by the probe field is stored into atomic spin coherence. By manipulating the frequency and spatial propagation direction of the read control field, the stored image is transferred into a new spatial-frequency channel. When two read control fields are used to retrieve the stored information, the image information is converted into a superposition of two spatial-frequency modes. Through this technique, the image is manipulated coherently and all-optically in a controlled fashion. PMID:26658846

Optical superheterodyne receiver.

NASA Technical Reports Server (NTRS)

Duval, K.; Lang, K.; Lucy, R. F.; Peters, C. J.

1967-01-01

Optical communication experiments to compare coherent and noncoherent optical detection fading characteristics in different weather conditions, using laser transmitter and optical superheterodyne receiver

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

NASA Astrophysics Data System (ADS)

Wen, Xiang; Jacques, Steven L.; Tuchin, Valery V.; Zhu, Dan

2012-06-01

The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Zthreshold.

Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

NASA Astrophysics Data System (ADS)

Liu, Chih-Hao; Singh, Manmohan; Li, Jiasong; Han, Zhaolong; Wu, Chen; Wang, Shang; Idugboe, Rita; Raghunathan, Raksha; Zakharov, Valery P.; Sobol, Emil N.; Tuchin, Valery V.; Twa, Michael; Larin, Kirill V.

2015-03-01

We report the first study on using optical coherence elastography (OCE) to quantitatively monitor the elasticity change of the hyaline cartilage during the optical clearing administrated by glucose solution. The measurement of the elasticity is verified using uniaxial compression test, demonstrating the feasibility of using OCE to quantify the Young's modulus of the cartilage tissue. As the results, we found that the stiffness of the hyaline cartilage increases during the optical clearing of the tissue. This study might be potentially useful for the early detection of osteoarthritis disease.

Fabrication of Fiber Optic Grating Apparatus and Method

NASA Technical Reports Server (NTRS)

Wang, Ying (Inventor); Sharma, Anup (Inventor); Grant, Joseph (Inventor)

2005-01-01

An apparatus and method for forming a Bragg grating on an optical fiber using a phase mask to diffract a beam of coherent energy and a lens combined with a pair of mirrors to produce two symmetrical virtual point sources of coherent energy in the plane of the optical fiber. The two virtual light sources produce an interference pattern along the optical fiber. In a further embodiment, the period of the pattern and therefore the Bragg wavelength grating applied to the fiber is varied with the position of the optical fiber relative the lens.

Recent advancements in robotic micro-optical assembly at the Lockheed Martin Optical Payload Center of Excellence

NASA Astrophysics Data System (ADS)

Hwang, David; Larson, Thomas M.

2017-08-01

Lockheed Martin Space Systems Company Optical Payloads Center of Excellence is in process of standing up the Robotic Optical Assembly System (ROAS) capability at Lockheed Martin Coherent Technologies in Colorado. This currently implemented Robotic Optical Assembly has enabled Lockheed Martin to create world-leading, ultra-lowSWAP photonic devices using a closed-loop control robot to precisely position and align micro-optics with a potential fill factor of >25 optics per square inch. This paper will discuss the anticipated applications and optical capability when ROAS is fully operational, as well as challenge the audience to update their "rules of thumb" and best practices when designing low-SWAP optical-mechanical systems that take advantage of Lockheed Martin's ROAS capability. This paper will reveal demonstrated optical pointing and stability performance achievable with ROAS and why we believe these optical specifications are relevant for the majority of anticipated applications. After a high level overview of the ROAS current state, this paper will focus in on recent results of the "Reworkable Micro-Optics Mounting IRAD". Results from this IRAD will correlate to the anticipated optical specifications required for relevant applications.

A comparison between using incoherent or coherent sources to align and test an adaptive optical telescope

NASA Technical Reports Server (NTRS)

Anderson, Richard

1994-01-01

The concept in the initial alignment of the segmented mirror adaptive optics telescope called the phased array mirror extendable large aperture telescope (Pamela) is to produce an optical transfer function (OTF) which closely approximates the diffraction limited value which would correspond to a system pupil function that is unity over the aperture and zero outside. There are differences in the theory of intensity measurements between coherent and incoherent radiation. As a result, some of the classical quantities which describe the performance of an optical system for incoherent radiation can not be defined for a coherent field. The most important quantity describing the quality of an optical system is the OTF and for a coherent source the OTF is not defined. Instead a coherent transfer function (CTF) is defined. The main conclusion of the paper is that an incoherent collimated source and not a collimated laser source is preferred to calibrate the Hartmann wavefront sensor (WFS) of an aligned adaptive optical system. A distant laser source can be used with minimum problems to correct the system for atmospheric turbulence. The collimation of the HeNe laser alignment source can be improved by using a very small pin hole in the spatial filter so only the central portion of the beam is transmitted and the beam from the filter is nearly constant in amplitude. The size of this pin hole will be limited by the sensitivity of the lateral effect diode (LEDD) elements.

Marginal adaptation of ceramic veneers investigated with en face optical coherence tomography

NASA Astrophysics Data System (ADS)

Sinescu, Cosmin; Negruţiu, Meda-Lavinia; Petrescu, Emanuela; Rominu, Mihai; Marcauteanu, Corina; Rominu, Roxana; Hughes, Michael; Bradu, Adrian; Dobre, George; Podoleanu, Adrian G.

2009-07-01

The aim of this study was to analyze the quality of marginal adaptation and gap width of Empress veneers using en-face optical coherence tomography. The results prove the necessity of investigating the marginal adaptation after each veneer bonding process.

Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review

PubMed Central

Sharif, S.A.; Taydas, E.; Mazhar, A.; Rahimian, R.; Kelly, K.M.; Choi, B.; Durkin, A.J.

2012-01-01

Port wine stain (PWS) birthmarks are one class of benign congenital vascular malformation. Laser therapy is the most successful treatment modality of PWS. Unfortunately, this approach has limited efficacy, with only 10% of patients experiencing complete blanching of the PWS. To address this problem, several research groups have developed technologies and methods designed to study treatment outcome and improve treatment efficacy. This paper reviews seven optical imaging techniques currently in use or under development to assess treatment efficacy, focusing on: Reflectance spectrophotometers/tristimulus colorimeters, Laser Doppler flowmetry (LDF) and Laser Doppler imaging (LDI), Cross-polarized diffuse reflectance color imaging system (CDR), Reflectance Confocal Microscopy (RCM), Optical Coherence Tomography (OCT), Spatial Frequency Domain Imaging (SFDI), and Laser Speckle Imaging (LSI). PMID:22804872

Film characteristics pertinent to coherent optical data processing systems.

PubMed

Thomas, C E

1972-08-01

Photographic film is studied quantitatively as the input mechanism for coherent optical data recording and processing systems. The two important film characteristics are the amplitude transmission vs exposure (T(A) - E) curve and the film noise power spectral density. Both functions are measured as a function of the type of film, the type of developer, developer time and temperature, and the exposing and readout light wavelengths. A detailed analysis of a coherent optical spatial frequency analyzer reveals that the optimum do bias point for 649-F film is an amplitude transmission of about 70%. This operating point yields minimum harmonic and intermodulation distortion, whereas the 50% amplitude transmission bias point recommended by holographers yields maximum diffraction efficiency. It is also shown that the effective ac gain or contrast of the film is nearly independent of the development conditions for a given film. Finally, the linear dynamic range of one particular coherent optical spatial frequency analyzer is shown to be about 40-50 dB.

Benign familial fleck retina: multimodal imaging including optical coherence tomography angiography.

PubMed

Garcia, Jose Mauricio Botto de Barros; Isaac, David Leonardo Cruvinel; Sardeiro, Tainara; Aquino, Érika; Avila, Marcos

2017-01-01

This report presents multimodal imaging of a 27-year-old woman diagnosed with benign familial fleck retina (OMIM 228980), an uncommon disorder. Fundus photographs revealed retinal flecks that affected her post-equatorial retina but spared the macular area. Fundus autofluorescence and infrared imaging demonstrated a symmetrical pattern of yellow-white fleck lesions that affected both eyes. Her full-field electroretinogram and electrooculogram were normal. An optical coherence tomography B-scan was performed for both eyes, revealing increased thickness of the retinal pigmented epithelium leading to multiple small pigmented epithelium detachments. The outer retina remained intact in both eyes. Spectral-domain optical coherence tomography angiography with split-spectrum amplitude decorrelation algorithm and 3 × 3 mm structural en face optical coherence tomography did not show macular lesions. Benign familial fleck retina belongs to a heterogenous group of so-called flecked retina syndromes, and should be considered in patients with yellowish-white retinal lesions without involvement of the macula.

Coherent perfect rotation theory: connections with, and consequences beyond, the anti-laser

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Andrews, James; Zhou, Chuanhong; Baker, Michael

2014-05-01

Coherent Perfect Rotation (CPR) phenomena are a reversible generalization of the anti-laser. By evaluating CPR in a broad variety of common optical systems, including optical cavities and DFB and DBR structures, we illustrate its unique threshold and resonance features. This study builds intuition critical to assessing the utility of CPR in optical devices, and we detail it in a concrete application.

Retinal Optical Coherence Tomography Imaging

NASA Astrophysics Data System (ADS)

Drexler, Wolfgang; Fujimoto, James G.

The eye is essentially transparent, transmitting light with only minimal optical attenuation and scattering providing easy optical access to the anterior segment as well as the retina. For this reason, ophthalmic and especially retinal imaging has been not only the first but also most successful clinical application for optical coherence tomography (OCT). This chapter focuses on the development of OCT technology for retinal imaging. OCT has significantly improved the potential for early diagnosis, understanding of retinal disease pathogenesis, as well as monitoring disease progression and response to therapy. Development of ultrabroad bandwidth light sources and high-speed detection techniques has enabled significant improvements in ophthalmic OCT imaging performance, demonstrating the potential of three-dimensional, ultrahigh-resolution OCT (UHR OCT) to perform noninvasive optical biopsy of the living human retina, i.e., the in vivo visualization of microstructural, intraretinal morphology in situ approaching the resolution of conventional histopathology. Significant improvements in axial resolution and speed not only enable three-dimensional rendering of retinal volumes but also high-definition, two-dimensional tomograms, topographic thickness maps of all major intraretinal layers, as well as volumetric quantification of pathologic intraretinal changes. These advances in OCT technology have also been successfully applied in several animal models of retinal pathologies. The development of light sources emitting at alternative wavelengths, e.g., around #1,060 nm, not only enabled three-dimensional OCT imaging with enhanced choroidal visualization but also improved OCT performance in cataract patients due to reduced scattering losses in this wavelength region. Adaptive optics using deformable mirror technology, with unique high stroke to correct higher-order ocular aberrations, with specially designed optics to compensate chromatic aberration of the human eye, in combination with three-dimensional UHR OCT, recently enabled in vivo cellular resolution retinal imaging.

Apparatus for generating partially coherent radiation

DOEpatents

Naulleau, Patrick P.

2004-09-28

The effective coherence of an undulator beamline can be tailored to projection lithography requirements by using a simple single moving element and a simple stationary low-cost spherical mirror. The invention is particularly suited for use in an illuminator device for an optical image processing system requiring partially coherent illumination. The illuminator includes: (i) source of coherent or partially coherent radiation which has an intrinsic coherence that is higher than the desired coherence; (ii) a reflective surface that receives incident radiation from said source; (iii) means for moving the reflective surface through a desired range of angles in two dimensions wherein the rate of the motion is fast relative to integration time of said image processing system; and (iv) a condenser optic that re-images the moving reflective surface to the entrance plane of said image processing system, thereby, making the illumination spot in said entrance plane essentially stationary.

Depth-resolved birefringence and differential optical axis orientation measurements with fiber-based polarization-sensitive optical coherence tomography.

PubMed

Guo, Shuguang; Zhang, Jun; Wang, Lei; Nelson, J Stuart; Chen, Zhongping

2004-09-01

Conventional polarization-sensitive optical coherence tomography (PS-OCT) can provide depth-resolved Stokes parameter measurements of light reflected from turbid media. A new algorithm that takes into account changes in the optical axis is introduced to provide depth-resolved birefringence and differential optical axis orientation images by use of fiber-based PS-OCT. Quaternion, a convenient mathematical tool, is used to represent an optical element and simplify the algorithm. Experimental results with beef tendon and rabbit tendon and muscle show that this technique has promising potential for imaging the birefringent structure of multiple-layer samples with varying optical axes.

Fourier phase in Fourier-domain optical coherence tomography.

PubMed

Uttam, Shikhar; Liu, Yang

2015-12-01

Phase of an electromagnetic wave propagating through a sample-of-interest is well understood in the context of quantitative phase imaging in transmission-mode microscopy. In the past decade, Fourier-domain optical coherence tomography has been used to extend quantitative phase imaging to the reflection-mode. Unlike transmission-mode electromagnetic phase, however, the origin and characteristics of reflection-mode Fourier phase are poorly understood, especially in samples with a slowly varying refractive index. In this paper, the general theory of Fourier phase from first principles is presented, and it is shown that Fourier phase is a joint estimate of subresolution offset and mean spatial frequency of the coherence-gated sample refractive index. It is also shown that both spectral-domain phase microscopy and depth-resolved spatial-domain low-coherence quantitative phase microscopy are special cases of this general theory. Analytical expressions are provided for both, and simulations are presented to explain and support the theoretical results. These results are further used to show how Fourier phase allows the estimation of an axial mean spatial frequency profile of the sample, along with depth-resolved characterization of localized optical density change and sample heterogeneity. Finally, a Fourier phase-based explanation of Doppler optical coherence tomography is also provided.

Quantitative shear wave imaging optical coherence tomography for noncontact mechanical characterization of myocardium

NASA Astrophysics Data System (ADS)

Wang, Shang; Lopez, Andrew L.; Morikawa, Yuka; Tao, Ge; Li, Jiasong; Larina, Irina V.; Martin, James F.; Larin, Kirill V.

2015-03-01

Optical coherence elastography (OCE) is an emerging low-coherence imaging technique that provides noninvasive assessment of tissue biomechanics with high spatial resolution. Among various OCE methods, the capability of quantitative measurement of tissue elasticity is of great importance for tissue characterization and pathology detection across different samples. Here we report a quantitative OCE technique, termed quantitative shear wave imaging optical coherence tomography (Q-SWI-OCT), which enables noncontact measurement of tissue Young's modulus based on the ultra-fast imaging of the shear wave propagation inside the sample. A focused air-puff device is used to interrogate the tissue with a low-pressure short-duration air stream that stimulates a localized displacement with the scale at micron level. The propagation of this tissue deformation in the form of shear wave is captured by a phase-sensitive OCT system running with the scan of the M-mode imaging over the path of the wave propagation. The temporal characteristics of the shear wave is quantified based on the cross-correlation of the tissue deformation profiles at all the measurement locations, and linear regression is utilized to fit the data plotted in the domain of time delay versus wave propagation distance. The wave group velocity is thus calculated, which results in the quantitative measurement of the Young's modulus. As the feasibility demonstration, experiments are performed on tissuemimicking phantoms with different agar concentrations and the quantified elasticity values with Q-SWI-OCT agree well with the uniaxial compression tests. For functional characterization of myocardium with this OCE technique, we perform our pilot experiments on ex vivo mouse cardiac muscle tissues with two studies, including 1) elasticity difference of cardiac muscle under relaxation and contract conditions and 2) mechanical heterogeneity of the heart introduced by the muscle fiber orientation. Our results suggest the potential of using Q-SWI-OCT as an essential tool for nondestructive biomechanical evaluation of myocardium.

Scatter sensitive microscopic techniques to identify contrasting mucosal structures in ultrahigh-resolution optical coherence tomograms of mouse colon

NASA Astrophysics Data System (ADS)

Tumlinson, Alexandre R.; Hariri, Lida P.; Drexler, Wolfgang; Barton, Jennifer K.

2008-02-01

Optical coherence tomography, optical coherence microscopy, reflectance confocal microscopy, and darkfield microscopy all derive contrast from the intensity of endogenous tissue scatter. We have imaged excised mouse colon tissue with these complimentary technologies to make conclusions about structural origins of scatter in the mouse colonic mucosa observed with endoscopic OCT. We find hyperintense scattering both from the cytoplasm of epithelial cells and from the boundary between epithelia and the lamina propria. We find almost no scatter from the portion of epithelial cells containing the nucleus. These observations substantiate explanations for the appearance of colonic crypts and the luminal surface.

Optical coherence tomography of the preterm eye: from retinopathy of prematurity to brain development

PubMed Central

Rothman, Adam L; Mangalesh, Shwetha; Chen, Xi; Toth, Cynthia A

2016-01-01

Preterm infants with retinopathy of prematurity are at increased risk of poor neurodevelopmental outcomes. Because the neurosensory retina is an extension of the central nervous system, anatomic abnormalities in the anterior visual pathway often relate to system and central nervous system health. We describe optical coherence tomography as a powerful imaging modality that has recently been adapted to the infant population and provides noninvasive, high-resolution, cross-sectional imaging of the infant eye at the bedside. Optical coherence tomography has increased understanding of normal eye development and has identified several potential biomarkers of brain abnormalities and poorer neurodevelopment. PMID:28539807

Common-path low-coherence interferometry fiber-optic sensor guided microincision

NASA Astrophysics Data System (ADS)

Zhang, Kang; Kang, Jin U.

2011-09-01

We propose and demonstrate a common-path low-coherence interferometry (CP-LCI) fiber-optic sensor guided precise microincision. The method tracks the target surface and compensates the tool-to-surface relative motion with better than +/-5 μm resolution using a precision micromotor connected to the tool tip. A single-fiber distance probe integrated microdissector was used to perform an accurate 100 μm incision into the surface of an Intralipid phantom. The CP-LCI guided incision quality in terms of depth was evaluated afterwards using three-dimensional Fourier-domain optical coherence tomography imaging, which showed significant improvement of incision accuracy compared to free-hand-only operations.

Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, Wenjuan; Department of Chemical Engineering and Materials Science, University of California, Irvine, Irvine, California 92697; Li, Rui

2014-03-24

We designed and developed a confocal acoustic radiation force optical coherence elastography system. A ring ultrasound transducer was used to achieve reflection mode excitation and generate an oscillating acoustic radiation force in order to generate displacements within the tissue, which were detected using the phase-resolved optical coherence elastography method. Both phantom and human tissue tests indicate that this system is able to sense the stiffness difference of samples and quantitatively map the elastic property of materials. Our confocal setup promises a great potential for point by point elastic imaging in vivo and differentiation of diseased tissues from normal tissue.

Spectral fractionation detection of gold nanorod contrast agents using optical coherence tomography

PubMed Central

Jia, Yali; Liu, Gangjun; Gordon, Andrew Y.; Gao, Simon S.; Pechauer, Alex D.; Stoddard, Jonathan; McGill, Trevor J.; Jayagopal, Ashwath; Huang, David

2015-01-01

We demonstrate the proof of concept of a novel Fourier-domain optical coherence tomography contrast mechanism using gold nanorod contrast agents and a spectral fractionation processing technique. The methodology detects the spectral shift of the backscattered light from the nanorods by comparing the ratio between the short and long wavelength halves of the optical coherence tomography signal intensity. Spectral fractionation further divides the halves into sub-bands to improve spectral contrast and suppress speckle noise. Herein, we show that this technique can detect gold nanorods in intralipid tissue phantoms. Furthermore, cellular labeling by gold nanorods was demonstrated using retinal pigment epithelial cells in vitro. PMID:25836459

Fiber-coupling efficiency for free-space optical communication through atmospheric turbulence.

PubMed

Dikmelik, Yamaç; Davidson, Frederic M

2005-08-10

High-speed free-space optical communication systems have recently used fiber-optic components. The received laser beam in such a system must be coupled into a single-mode fiber at the input of the receiver module. However, propagation through atmospheric turbulence degrades the spatial coherence of a laser beam and limits the fiber-coupling efficiency. We numerically evaluate the fiber-coupling efficiency for laser light distorted by atmospheric turbulence. We also investigate the use of a coherent fiber array as a receiver structure and find that a coherent fiber array that consists of seven subapertures would significantly increase the fiber-coupling efficiency.

[Application of spectral optical coherent tomography (SOCT) in ophthalmology].

PubMed

Bieganowski, Lech; Wojtkowski, Maciej; Kowalczyk, Andrzej; Kałuzny, Jakub J

2004-01-01

The article describes spectral optical coherent tomography (SOCT) constructed by Medical Physics Group, Faculty of Physics, Astronomy and Informatics at Nicholas Copernicus University in Toruń (Poland). It presents the physical bases for the functioning of the constructed device and includes pictures of optical sections of various elements of the eyeball: an optic disc and the region of central fovea, a cornea and angle structures (trabecular meshwork). The article also discusses potential application of SOCT in ophthalmic diagnosis of anterior and posterior segments of the eye.

Secure coherent optical multi-carrier system with four-dimensional modulation space and Stokes vector scrambling.

PubMed

Zhang, Lijia; Liu, Bo; Xin, Xiangjun

2015-06-15

A secure enhanced coherent optical multi-carrier system based on Stokes vector scrambling is proposed and experimentally demonstrated. The optical signal with four-dimensional (4D) modulation space has been scrambled intra- and inter-subcarriers, where a multi-layer logistic map is adopted as the chaotic model. An experiment with 61.71-Gb/s encrypted multi-carrier signal is successfully demonstrated with the proposed method. The results indicate a promising solution for the physical secure optical communication.

Analog signal processing for optical coherence imaging systems

NASA Astrophysics Data System (ADS)

Xu, Wei

Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are non-invasive optical coherence imaging techniques, which enable micron-scale resolution, depth resolved imaging capability. Both OCT and OCM are based on Michelson interferometer theory. They are widely used in ophthalmology, gastroenterology and dermatology, because of their high resolution, safety and low cost. OCT creates cross sectional images whereas OCM obtains en face images. In this dissertation, the design and development of three increasingly complicated analog signal processing (ASP) solutions for optical coherence imaging are presented. The first ASP solution was implemented for a time domain OCT system with a Rapid Scanning Optical Delay line (RSOD)-based optical signal modulation and logarithmic amplifier (Log amp) based demodulation. This OCT system can acquire up to 1600 A-scans per second. The measured dynamic range is 106dB at 200A-scan per second. This OCT signal processing electronics includes an off-the-shelf filter box with a Log amp circuit implemented on a PCB board. The second ASP solution was developed for an OCM system with synchronized modulation and demodulation and compensation for interferometer phase drift. This OCM acquired micron-scale resolution, high dynamic range images at acquisition speeds up to 45,000 pixels/second. This OCM ASP solution is fully custom designed on a perforated circuit board. The third ASP solution was implemented on a single 2.2 mm x 2.2 mm complementary metal oxide semiconductor (CMOS) chip. This design is expandable to a multiple channel OCT system. A single on-chip CMOS photodetector and ASP channel was used for coherent demodulation in a time domain OCT system. Cross-sectional images were acquired with a dynamic range of 76dB (limited by photodetector responsivity). When incorporated with a bump-bonded InGaAs photodiode with higher responsivity, the expected dynamic range is close to 100dB.

The study of documentary photographs of the early 20th century by the optical coherence microscopy method

NASA Astrophysics Data System (ADS)

Ryseva, Ekaterina; Zhukova, Ekaterina

2013-05-01

The wide field and spectral methods of optical coherence microscopy were used for extensive studying the photographs printed in the early 20th century. Tomographic images (B-scans) of photo and paper materials are presented and discussed.

Studies of dynamic processes in biomedicine by high-speed spectral optical coherence tomography

NASA Astrophysics Data System (ADS)

Wojtkowski, M.; Kowalczyk, A.

2007-02-01

This contribution demonstrates potential of Spectral Optical Coherence Tomography (SOCT) for studies of dynamic processes in biomedicine occurring at various time scales. Several examples from ophthalmology, optometry, surgery, neurology are given to illustrate the extension of SOCT beyond pure morphological investigations.

Adiabatic passage in photon-echo quantum memories

NASA Astrophysics Data System (ADS)

Demeter, Gabor

2013-11-01

Photon-echo-based quantum memories use inhomogeneously broadened, optically thick ensembles of absorbers to store a weak optical signal and employ various protocols to rephase the atomic coherences for information retrieval. We study the application of two consecutive, frequency-chirped control pulses for coherence rephasing in an ensemble with a “natural” inhomogeneous broadening. Although propagation effects distort the two control pulses differently, chirped pulses that drive adiabatic passage can rephase atomic coherences in an optically thick storage medium. Combined with spatial phase-mismatching techniques to prevent primary echo emission, coherences can be rephased around the ground state to achieve secondary echo emission with close to unit efficiency. Potential advantages over similar schemes working with π pulses include greater potential signal fidelity, reduced noise due to spontaneous emission, and better capability for the storage of multiple memory channels.

Role of coherence in microsphere-assisted nanoscopy

NASA Astrophysics Data System (ADS)

Perrin, Stephane; Lecler, Sylvain; Leong-Hoi, Audrey; Montgomery, Paul C.

2017-06-01

The loss of the information, due to the diffraction and the evanescent waves, limits the resolving power of classical optical microscopy. In air, the lateral resolution of an optical microscope can approximated at half of the wavelength using a low-coherence illumination. Recently, several methods have been developed in order to overcome this limitation and, in 2011, a new far-field and full-field imaging technique was proposed where a sub-diffraction-limit resolution has been achieved using a transparent microsphere. In this article, the phenomenon of super-resolution using microsphere-assisted microscopy is analysed through rigorous electro-magnetic simulations. The performances of the imaging technique are estimated as function of optical and geometrical parameters. Furthermore, the role of coherence is introduced through the temporal coherence of the light source and the phase response of the object.

A wide angle low coherence interferometry based eye length optometer

NASA Astrophysics Data System (ADS)

Meadway, Alexander; Siegwart, John; Wildsoet, Christine; Norton, Thomas; Zhang, Yuhua

2015-03-01

Interest in eye growth regulation has burgeoned with the rise in myopia prevalence world-wide. Eye length and eye shape are fundamental metrics for related research, but current in vivo measurement techniques are generally limited to the optical axis of the eye. We describe a high resolution, time domain low coherence interferometry based optometer for measuring the eye length of small animals over a wide field of view. The system is based upon a Michelson interferometer using a superluminescent diode as a source, including a sample arm and a reference arm. The sample arm is split into two paths by a polarisation beam splitter; one focuses the light on the cornea and the other focuses the light on the retina. This method has a high efficiency of detection for reflections from both surfaces. The reference arm contains a custom high speed linear motor with 25 mm stroke and equipped with a precision displacement encoder. Light reflected from the cornea and the retina is combined with the reference beam to generate low coherence interferograms. Two galvo scanners are employed to steer the light to different angles so that the eye length over a field of view of 20° × 20° can be measured. The system has an axial resolution of 6.8 μm (in air) and the motor provides accurate movement, allowing for precise and repeatable measurement of coherence peak positions. Example scans from a tree shrew are presented.

Coherent Soft X-ray Diffraction Imaging of Coliphage PR772 at the Linac Coherent Light Source

DOE Data Explorer

Reddy, Hemanth, K.N.

2017-01-05

A dataset of coherent soft X-ray diffraction images of Coliphage PR772 virus, collected at the Atomic Molecular Optics (AMO) beamline with pnCCD detectors in the LAMP instrument at the Linac Coherent Light Source.

Coherent Detection of High-Rate Optical PPM Signals

NASA Technical Reports Server (NTRS)

Vilnrotter, Victor; Fernandez, Michela Munoz

2006-01-01

A method of coherent detection of high-rate pulse-position modulation (PPM) on a received laser beam has been conceived as a means of reducing the deleterious effects of noise and atmospheric turbulence in free-space optical communication using focal-plane detector array technologies. In comparison with a receiver based on direct detection of the intensity modulation of a PPM signal, a receiver based on the present method of coherent detection performs well at much higher background levels. In principle, the coherent-detection receiver can exhibit quantum-limited performance despite atmospheric turbulence. The key components of such a receiver include standard receiver optics, a laser that serves as a local oscillator, a focal-plane array of photodetectors, and a signal-processing and data-acquisition assembly needed to sample the focal-plane fields and reconstruct the pulsed signal prior to detection. The received PPM-modulated laser beam and the local-oscillator beam are focused onto the photodetector array, where they are mixed in the detection process. The two lasers are of the same or nearly the same frequency. If the two lasers are of different frequencies, then the coherent detection process is characterized as heterodyne and, using traditional heterodyne-detection terminology, the difference between the two laser frequencies is denoted the intermediate frequency (IF). If the two laser beams are of the same frequency and remain aligned in phase, then the coherent detection process is characterized as homodyne (essentially, heterodyne detection at zero IF). As a result of the inherent squaring operation of each photodetector, the output current includes an IF component that contains the signal modulation. The amplitude of the IF component is proportional to the product of the local-oscillator signal amplitude and the PPM signal amplitude. Hence, by using a sufficiently strong local-oscillator signal, one can make the PPM-modulated IF signal strong enough to overcome thermal noise in the receiver circuits: this is what makes it possible to achieve near-quantum-limited detection in the presence of strong background. Following quantum-limited coherent detection, the outputs of the individual photodetectors are automatically aligned in phase by use of one or more adaptive array compensation algorithms [e.g., the least-mean-square (LMS) algorithm]. Then the outputs are combined and the resulting signal is processed to extract the high-rate information, as though the PPM signal were received by a single photodetector. In a continuing series of experiments to test this method (see Fig. 1), the local oscillator has a wavelength of 1,064 nm, and another laser is used as a signal transmitter at a slightly different wavelength to establish an IF of about 6 MHz. There are 16 photodetectors in a 4 4 focal-plane array; the detector outputs are digitized at a sampling rate of 25 MHz, and the signals in digital form are combined by use of the LMS algorithm. Convergence of the adaptive combining algorithm in the presence of simulated atmospheric turbulence for optical PPM signals has already been demonstrated in the laboratory; the combined output is shown in Fig. 2(a), and Fig. 2(b) shows the behavior of the phase of the combining weights as a function of time (or samples). We observe that the phase of the weights has a sawtooth shape due to the continuously changing phase in the down-converted output, which is not exactly at zero frequency. Detailed performance analysis of this coherent free-space optical communication system in the presence of simulated atmospheric turbulence is currently under way.

Coherent beam combining in atmospheric channels using gated backscatter.

PubMed

Naeh, Itay; Katzir, Abraham

2016-02-01

This paper introduces the concept of atmospheric channels and describes a possible approach for the coherent beam combining of lasers of an optical phased array (OPA) in a turbulent atmosphere. By using the recently introduced sparse spectrum harmonic augmentation method, a comprehensive simulative investigation was performed and the exceptional properties of the atmospheric channels were numerically demonstrated. Among the interesting properties are the ability to guide light in a confined manner in a refractive channel, the ability to gather different sources to the same channel, and the ability to maintain a constant relative phase within the channel between several sources. The newly introduced guiding properties combined with a suggested method for channel probing and phase measurement by aerosol backscattered radiation allows coherence improvement of the phased array's elements and energy refocusing at the location of the channel in order to increase power in the bucket without feedback from the target. The method relies on the electronic focusing, electronic scanning, and time gating of the OPA, combined with elements of the relative phase measurements.

Measurement of the thickness of the lens with the use of all fiber low-coherence interferometer

NASA Astrophysics Data System (ADS)

Józwik, Michalina; Stepień, Karol; Lipiński, Stanisław; Budnicki, Dawid; Napierała, Marek; Nasiłowski, Tomasz

2015-12-01

In this paper we present experimental results of measurements of the lens thickness carried out using all fiber low coherence interferometer. A new interferometric device for measuring the thickness of the lens using optical fibers has been developed in response to market demand. It ensures fast, non-contact and accurate measurement. This work focuses above all on the conducting tests to determine the repeatability of the measurement and to verify the ability of using this method in industrial conditions. The system uses a Mach-Zehnder interferometer in which one of the arms is the reference part and the second arm containing the test element is the measurement part. The measurement rate and the easiness of placement of the test lens in the system give the possibility to automate the measurement process. We present the measurement results, which show that the use of low-coherence interferometry allows achieving high measurement accuracy and meeting other industrial needs.

High-speed optical coherence tomography by circular interferometric ranging

NASA Astrophysics Data System (ADS)

Siddiqui, Meena; Nam, Ahhyun S.; Tozburun, Serhat; Lippok, Norman; Blatter, Cedric; Vakoc, Benjamin J.

2018-02-01

Existing three-dimensional optical imaging methods excel in controlled environments, but are difficult to deploy over large, irregular and dynamic fields. This means that they can be ill-suited for use in areas such as material inspection and medicine. To better address these applications, we developed methods in optical coherence tomography to efficiently interrogate sparse scattering fields, that is, those in which most locations (voxels) do not generate meaningful signal. Frequency comb sources are used to superimpose reflected signals from equispaced locations through optical subsampling. This results in circular ranging, and reduces the number of measurements required to interrogate large volumetric fields. As a result, signal acquisition barriers that have limited speed and field in optical coherence tomography are avoided. With a new ultrafast, time-stretched frequency comb laser design operating with 7.6 MHz to 18.9 MHz repetition rates, we achieved imaging of multi-cm3 fields at up to 7.5 volumes per second.

Experimental results of 5-Gbps free-space coherent optical communications with adaptive optics

NASA Astrophysics Data System (ADS)

Chen, Mo; Liu, Chao; Rui, Daoman; Xian, Hao

2018-07-01

In a free-space optical communication system with fiber optical components, the received signal beam must be coupled into a single-mode fiber (SMF) before being amplified and detected. The impacts analysis of tracking errors and wavefront distortion on SMF coupling show that under the condition of relatively strong turbulence, only the tracking errors compensation is not enough, and turbulence wavefront aberration is required to be corrected. Based on our previous study and design of SMF coupling system with a 137-element continuous surface deformable mirror AO unit, we perform an experiment of a 5-Gbps Free-space Coherent Optical Communication (FSCOC) system, in which the eye pattern and Bit-error Rate (BER) are displayed. The comparative results are shown that the influence of the atmospheric is fatal in FSCOC systems. The BER of coherent communication is under 10-6 with AO compensation, which drops significantly compared with the BER without AO correction.

Modeling of processes of formation of the images in optical-electronic systems

NASA Astrophysics Data System (ADS)

Grudin, B. N.; Plotnikov, V. S.; Fischenko, V. K.

2001-08-01

The digital model of the multicomponent coherent optical system with arbitrary layout of optical elements (lasers, lenses, phototransparencies with recording of the function of transmission of a specimens or filters, photoregistrars), constructed with usage of fast algorithms is considered. The model is realized as the program for personal computers in operational systems Windows 95, 98 and Windows NT. At simulation, for example, coherent system consisting of twenty elementary optical cascades a relative error in the output image as a rule does not exceed 0.25% when N >= 256 (N x N - the number of discrete samples on the image), and time of calculation of the output image on a computer (Pentium-2, 300 MHz) for N = 512 does not exceed one minute. The program of simulation of coherent optical systems will be utilized in scientific researches and at tutoring the students of Far East State University.

Performance analysis of fiber-based free-space optical communications with coherent detection spatial diversity.

PubMed

Li, Kangning; Ma, Jing; Tan, Liying; Yu, Siyuan; Zhai, Chao

2016-06-10

The performances of fiber-based free-space optical (FSO) communications over gamma-gamma distributed turbulence are studied for multiple aperture receiver systems. The equal gain combining (EGC) technique is considered as a practical scheme to mitigate the atmospheric turbulence. Bit error rate (BER) performances for binary-phase-shift-keying-modulated coherent detection fiber-based free-space optical communications are derived and analyzed for EGC diversity receptions through an approximation method. To show the net diversity gain of a multiple aperture receiver system, BER performances of EGC are compared with a single monolithic aperture receiver system with the same total aperture area (same average total incident optical power on the aperture surface) for fiber-based free-space optical communications. The analytical results are verified by Monte Carlo simulations. System performances are also compared for EGC diversity coherent FSO communications with or without considering fiber-coupling efficiencies.

DLP technolgy: applications in optical networking

NASA Astrophysics Data System (ADS)

Yoder, Lars A.; Duncan, Walter M.; Koontz, Elisabeth M.; So, John; Bartlett, Terry A.; Lee, Benjamin L.; Sawyers, Bryce D.; Powell, Donald; Rancuret, Paul

2001-11-01

For the past five years, Digital Light Processing (DLP) technology from Texas Instruments has made significant inroads in the projection display market. With products encompassing the world's smallest data & video projectors, HDTVs, and digital cinema, DLP is an extremely flexible technology. At the heart of these display solutions is Texas Instruments Digital Micromirror Device (DMD), a semiconductor-based light switch array of thousands of individually addressable, tiltable, mirror-pixels. With success of the DMD as a spatial light modulator in the visible regime, the use of DLP technology under the constraints of coherent, infrared light for optical networking applications is being explored. As a coherent light modulator, the DMD device can be used in Dense Wavelength Division Multiplexed (DWDM) optical networks to dynamically manipulate and shape optical signals. This paper will present the fundamentals of using DLP with coherent wavefronts, discuss inherent advantages of the technology, and present several applications for DLP in dynamic optical networks.

Optical design and simulation of a new coherence beamline at NSLS-II

NASA Astrophysics Data System (ADS)

Williams, Garth J.; Chubar, Oleg; Berman, Lonny; Chu, Yong S.; Robinson, Ian K.

2017-08-01

We will discuss the optical design for a proposed beamline at NSLS-II, a late-third generation storage ring source, designed to exploit the spatial coherence of the X-rays to extract high-resolution spatial information from ordered and disordered materials through Coherent Diffractive Imaging, executed in the Bragg- and forward-scattering geometries. This technique offers a powerful tool to image sub-10 nm spatial features and, within ordered materials, sub-Angstrom mapping of deformation fields. Driven by the opportunity to apply CDI to a wide range of samples, with sizes ranging from sub-micron to tens-of-microns, two optical designs have been proposed and simulated under a wide variety of optical configurations using the software package Synchrotron Radiation Workshop. The designs, their goals, and the results of the simulation, including NSLS-II ring and undulator source parameters, of the beamline performance as a function of its variable optical components is described.

LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: Characterisation of optically cleared paper by optical coherence tomography

NASA Astrophysics Data System (ADS)

Fabritius, T.; Alarousu, E.; Prykäri, T.; Hast, J.; Myllylä, Risto

2006-02-01

Due to the highly light scattering nature of paper, the imaging depth of optical methods such as optical coherence tomography (OCT) is limited. In this work, we study the effect of refractive index matching on improving the imaging depth of OCT in paper. To this end, four different refractive index matching liquids (ethanol, 1-pentanol, glycerol and benzyl alcohol) with a refraction index between 1.359 and 1.538 were used in experiments. Low coherent light transmission was studied in commercial copy paper sheets, and the results indicate that benzyl alcohol offers the best improvement in imaging depth, while also being sufficiently stable for the intended purpose. Constructed cross-sectional images demonstrate visually that the imaging depth of OCT is considerably improved by optical clearing. Both surfaces of paper sheets can be detected along with information about the sheet's inner structure.

Time-stretch microscopy based on time-wavelength sequence reconstruction from wideband incoherent source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Chi, E-mail: chizheung@gmail.com; Xu, Yiqing; Wei, Xiaoming

2014-07-28

Time-stretch microscopy has emerged as an ultrafast optical imaging concept offering the unprecedented combination of the imaging speed and sensitivity. However, dedicated wideband and coherence optical pulse source with high shot-to-shot stability has been mandated for time-wavelength mapping—the enabling process for ultrahigh speed wavelength-encoded image retrieval. From the practical point of view, exploiting methods to relax the stringent requirements (e.g., temporal stability and coherence) for the source of time-stretch microscopy is thus of great value. In this paper, we demonstrated time-stretch microscopy by reconstructing the time-wavelength mapping sequence from a wideband incoherent source. Utilizing the time-lens focusing mechanism mediated bymore » a narrow-band pulse source, this approach allows generation of a wideband incoherent source, with the spectral efficiency enhanced by a factor of 18. As a proof-of-principle demonstration, time-stretch imaging with the scan rate as high as MHz and diffraction-limited resolution is achieved based on the wideband incoherent source. We note that the concept of time-wavelength sequence reconstruction from wideband incoherent source can also be generalized to any high-speed optical real-time measurements, where wavelength is acted as the information carrier.« less

Multi-chord fiber-coupled interferometer with a long coherence length laser

NASA Astrophysics Data System (ADS)

Merritt, Elizabeth C.; Lynn, Alan G.; Gilmore, Mark A.; Hsu, Scott C.

2012-03-01

This paper describes a 561 nm laser heterodyne interferometer that provides time-resolved measurements of line-integrated plasma electron density within the range of 1015-1018 cm-2. Such plasmas are produced by railguns on the plasma liner experiment, which aims to produce μs-, cm-, and Mbar-scale plasmas through the merging of 30 plasma jets in a spherically convergent geometry. A long coherence length, 320 mW laser allows for a strong, sub-fringe phase-shift signal without the need for closely matched probe and reference path lengths. Thus, only one reference path is required for all eight probe paths, and an individual probe chord can be altered without altering the reference or other probe path lengths. Fiber-optic decoupling of the probe chord optics on the vacuum chamber from the rest of the system allows the probe paths to be easily altered to focus on different spatial regions of the plasma. We demonstrate that sub-fringe resolution capability allows the interferometer to operate down to line-integrated densities of the order of 5 × 1015 cm-2.

Stimulated penetrating keratoplasty using real-time virtual intraoperative surgical optical coherence tomography

PubMed Central

Lee, Changho; Kim, Kyungun; Han, Seunghoon; Kim, Sehui; Lee, Jun Hoon; Kim, Hong kyun; Kim, Chulhong; Jung, Woonggyu; Kim, Jeehyun

2014-01-01

Abstract. An intraoperative surgical microscope is an essential tool in a neuro- or ophthalmological surgical environment. Yet, it has an inherent limitation to classify subsurface information because it only provides the surface images. To compensate for and assist in this problem, combining the surgical microscope with optical coherence tomography (OCT) has been adapted. We developed a real-time virtual intraoperative surgical OCT (VISOCT) system by adapting a spectral-domain OCT scanner with a commercial surgical microscope. Thanks to our custom-made beam splitting and image display subsystems, the OCT images and microscopic images are simultaneously visualized through an ocular lens or the eyepiece of the microscope. This improvement helps surgeons to focus on the operation without distraction to view OCT images on another separate display. Moreover, displaying the OCT live images on the eyepiece helps surgeon’s depth perception during the surgeries. Finally, we successfully processed stimulated penetrating keratoplasty in live rabbits. We believe that these technical achievements are crucial to enhance the usability of the VISOCT system in a real surgical operating condition. PMID:24604471

In vivo monitoring laser tissue interaction using high resolution Fourier-domain optical coherence tomography

NASA Astrophysics Data System (ADS)

Jo, Hang Chan; Shin, Dong Jun; Ahn, Jin-Chul; Chung, Phil-Sang; Kim, DaeYu

2017-02-01

Laser-induced therapies include laser ablation to remove or cut target tissue by irradiating high-power focused laser beam. These laser treatments are widely used tools for minimally invasive surgery and retinal surgical procedures in clinical settings. In this study, we demonstrate laser tissue interaction images of various sample tissues using high resolution Fourier-domain optical coherence tomography (Fd-OCT). We use a Q-switch diode-pumped Nd:YVO4 nanosecond laser (532nm central wavelength) with a 4W maximum output power at a 20 kHz repetition rate to ablate in vitro and in vivo samples including chicken breast and mouse ear tissues. The Fd-OCT system acquires time-series Bscan images at the same location during the tissue ablation experiments with 532nm laser irradiation. The real-time series of OCT cross-sectional (B-scan) images compare structural changes of 532nm laser ablation using same and different laser output powers. Laser tissue ablation is demonstrated by the width and the depth of the tissue ablation from the B-scan images.

Optical coherence tomography in anterior segment imaging

PubMed Central

Kalev-Landoy, Maya; Day, Alexander C.; Cordeiro, M. Francesca; Migdal, Clive

2008-01-01

Purpose To evaluate the ability of optical coherence tomography (OCT), designed primarily to image the posterior segment, to visualize the anterior chamber angle (ACA) in patients with different angle configurations. Methods In a prospective observational study, the anterior segments of 26 eyes of 26 patients were imaged using the Zeiss Stratus OCT, model 3000. Imaging of the anterior segment was achieved by adjusting the focusing control on the Stratus OCT. A total of 16 patients had abnormal angle configurations including narrow or closed angles and plateau irides, and 10 had normal angle configurations as determined by prior full ophthalmic examination, including slit-lamp biomicroscopy and gonioscopy. Results In all cases, OCT provided high-resolution information regarding iris configuration. The ACA itself was clearly visualized in patients with narrow or closed angles, but not in patients with open angles. Conclusions Stratus OCT offers a non-contact, convenient and rapid method of assessing the configuration of the anterior chamber. Despite its limitations, it may be of help during the routine clinical assessment and treatment of patients with glaucoma, particularly when gonioscopy is not possible or difficult to interpret. PMID:17355288

The Use of Optical Coherence Tomography for the Detection of Early Diabetic Retinopathy.

PubMed

Somfai, Gabor Mark; Gerding, Heinrich; DeBuc, Delia Cabrera

2018-04-01

Diabetic retinopathy (DR) is one of the leading causes of vision loss globally with a severe burden on all societies due to its high treatment and rehabilitation costs. The early diagnosis of DR may provide preventive steps (including retinal laser therapy and tight carbohydrate, blood pressure, and cholesterol control) that could in turn help to avoid progression of the pathology with the resultant vision loss. Optical coherence tomography (OCT) enables the in vivo structural imaging of the retina, providing both qualitative (structure) and quantitative (thickness) information. In the past decades, extensive OCT research has been done in the field of DR. In the present review, we are focusing on those that were aiming at detection of the earliest retinal changes before DR could be diagnosed funduscopically. The latest, widely available technology of spectral-domain (SD-)OCT comes with a fast and reliable retinal imaging, which, together with the most recent developments in image processing and artificial intelligence, holds the promise of developing a quick and efficient, state-of-the-art screening tool for DR. Georg Thieme Verlag KG Stuttgart · New York.

The original method for imaging of biological tissues in optical coherence tomography with usage of hyperchromatic lens

NASA Astrophysics Data System (ADS)

Egorov, D. I.

2017-06-01

Our study focuses on an analysis of the original method of investigation biological tissues in the spectral OCT (optical coherence tomography) with usage hyperchromatic lenses. Using hyperchromatic lens, i.e. the lens with uncorrected longitudinal color allows scanning in the depth of the object by changing the wavelength of the emitter. In this case, the depth of the scan will be determined not by the microlens depth of field, but the value of axial color. In our study, we demonstrated the advantages of this method of research on biological tissues existing. Spectral OCT schemes with the hyperchromatic lens could increase the depth of spectral scanning, eliminate the use of multi-channel systems with a set of microscope objectives, reduce the time of measurement. In our paper, we show the developed method of calculation of hyperchromatic lenses and hybrid hyperchromatic lens consisting of a diffractive and refractive component in spectral OCT systems. We also demonstrate the results of aberration calculation designed microscope lenses. We show examples of developed hyperchromatic lenses with the diffractive element and without it.

Gabor fusion master slave optical coherence tomography

PubMed Central

Cernat, Ramona; Bradu, Adrian; Israelsen, Niels Møller; Bang, Ole; Rivet, Sylvain; Keane, Pearse A.; Heath, David-Garway; Rajendram, Ranjan; Podoleanu, Adrian

2017-01-01

This paper describes the application of the Gabor filtering protocol to a Master/Slave (MS) swept source optical coherence tomography (SS)-OCT system at 1300 nm. The MS-OCT system delivers information from selected depths, a property that allows operation similar to that of a time domain OCT system, where dynamic focusing is possible. The Gabor filtering processing following collection of multiple data from different focus positions is different from that utilized by a conventional swept source OCT system using a Fast Fourier transform (FFT) to produce an A-scan. Instead of selecting the bright parts of A-scans for each focus position, to be placed in a final B-scan image (or in a final volume), and discarding the rest, the MS principle can be employed to advantageously deliver signal from the depths within each focus range only. The MS procedure is illustrated on creating volumes of data of constant transversal resolution from a cucumber and from an insect by repeating data acquisition for 4 different focus positions. In addition, advantage is taken from the tolerance to dispersion of the MS principle that allows automatic compensation for dispersion created by layers above the object of interest. By combining the two techniques, Gabor filtering and Master/Slave, a powerful imaging instrument is demonstrated. The master/slave technique allows simultaneous display of three categories of images in one frame: multiple depth en-face OCT images, two cross-sectional OCT images and a confocal like image obtained by averaging the en-face ones. We also demonstrate the superiority of MS-OCT over its FFT based counterpart when used with a Gabor filtering OCT instrument in terms of the speed of assembling the fused volume. For our case, we show that when more than 4 focus positions are required to produce the final volume, MS is faster than the conventional FFT based procedure. PMID:28270987

Chirp optical coherence tomography of layered scattering media.

PubMed

Haberland, U H; Blazek, V; Schmitt, H J

1998-07-01

A new noninvasive technique that reveals cross sectional images of scattering media is presented. It is based on a continuous wave frequency modulated radar, but uses a tunable laser in the near infrared. As the full width at half maximum resolution of 16 μm is demonstrated with an external cavity laser, the chirp optical coherence tomography becomes an alternative to conventional short coherence tomography with the advantage of a simplified optical setup. The analysis of two-layer solid phantoms shows that the backscattered light gets stronger with decreasing anisotropic factor and increasing scattering coefficient, as predicted by Monte Carlo simulations. By introducing a two-phase chirp sequence, the combination of lateral resolved perfusion and depth resolved structure is shown. © 1998 Society of Photo-Optical Instrumentation Engineers.

In vivo size and shape measurement of the human upper airway using endoscopic longrange optical coherence tomography

NASA Astrophysics Data System (ADS)

Armstrong, Julian J.; Leigh, Matthew S.; Walton, Ian D.; Zvyagin, Andrei V.; Alexandrov, Sergey A.; Schwer, Stefan; Sampson, David D.; Hillman, David R.; Eastwood, Peter R.

2003-07-01

We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).

Coherent radio-frequency detection for narrowband direct comb spectroscopy.

PubMed

Anstie, James D; Perrella, Christopher; Light, Philip S; Luiten, Andre N

2016-02-22

We demonstrate a scheme for coherent narrowband direct optical frequency comb spectroscopy. An extended cavity diode laser is injection locked to a single mode of an optical frequency comb, frequency shifted, and used as a local oscillator to optically down-mix the interrogating comb on a fast photodetector. The high spectral coherence of the injection lock generates a microwave frequency comb at the output of the photodiode with very narrow features, enabling spectral information to be further down-mixed to RF frequencies, allowing optical transmittance and phase to be obtained using electronics commonly found in the lab. We demonstrate two methods for achieving this step: a serial mode-by-mode approach and a parallel dual-comb approach, with the Cs D1 transition at 894 nm as a test case.

DAWN Coherent Wind Profiling Lidar Flights on NASA's DC-8 During GRIP

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.; Beyon, Jeffrey Y.; Creary, Garfield A.; Koch, Grady J.; Petros, Mulugeta; Petzar, Paul J.; Singh, Upendra N.; Trieu, Bo C.; Yu, Jirong

2011-01-01

Almost from their invention, lasers have been used to measure the velocity of wind and objects; over distances of cm to 10s of km. Long distance (remote) sensing of wind has been accomplished with continuous-wave (CW), focused pulsed, and collimated pulsed lasers; with direct and coherent (heterodyne) optical detection; and with a multitude of laser wavelengths. Airborne measurement of wind with pulsed, coherent-detection lidar was first performed in 1971 with a CW CO2 laser1, in 1972 with a pulsed CO2 laser2, in 1993 with a pulsed 2-micron laser3, and in 1999 with a pulsed CO2 laser and nadir-centered conical scanning4. Of course there were many other firsts and many other groups doing lidar wind remote sensing with coherent and direct detection. A very large FOM coherent wind lidar has been built by LaRC and flown on a DC-8. However a burn on the telescope secondary mirror prevented the full demonstration of high FOM. Both the GRIP science product and the technology and technique demonstration from aircraft are important to NASA. The technology and technique demonstrations contribute to our readiness for the 3D Winds space mission. The data analysis is beginning and we hope to present results at the conference.

Multipion correlations induced by isospin conservation of coherent emission

DOE PAGES

Gangadharan, Dhevan

2016-09-15

Recent measurements have revealed a significant suppression of multipion Bose–Einstein correlations in heavy-ion collisions at the LHC. The suppression may be explained by postulating coherent pion emission. Typically, the suppression of Bose–Einstein correlations due to coherence is taken into account with the coherent state formalism in quantum optics. However, since charged pion correlations are most often measured, the additional constraint of isospin conservation, which is absent in quantum optics, needs to be taken into account. As a consequence, correlations emerge between pions of opposite charge. A calculation of the correlations induced by isospin conservation of coherent emission is made formore » two, three- and four-pion correlation functions and compared to the data from the LHC.« less

Nuclear spin cooling by electric dipole spin resonance and coherent population trapping

NASA Astrophysics Data System (ADS)

Li, Ai-Xian; Duan, Su-Qing; Zhang, Wei

2017-09-01

Nuclear spin fluctuation suppression is a key issue in preserving electron coherence for quantum information/computation. We propose an efficient way of nuclear spin cooling in semiconductor quantum dots (QDs) by the coherent population trapping (CPT) and the electric dipole spin resonance (EDSR) induced by optical fields and ac electric fields. The EDSR can enhance the spin flip-flop rate and may bring out bistability under certain conditions. By tuning the optical fields, we can avoid the EDSR induced bistability and obtain highly polarized nuclear spin state, which results in long electron coherence time. With the help of CPT and EDSR, an enhancement of 1500 times of the electron coherence time can been obtained after a 500 ns preparation time.

Frequency multiplexed long range swept source optical coherence tomography

PubMed Central

Zurauskas, Mantas; Bradu, Adrian; Podoleanu, Adrian Gh.

2013-01-01

We present a novel swept source optical coherence tomography configuration, equipped with acousto-optic deflectors that can be used to simultaneously acquire multiple B-scans originating from different depths. The sensitivity range of the configuration is evaluated while acquiring five simultaneous B-scans. Then the configuration is employed to demonstrate long range B-scan imaging by combining two simultaneous B-scans from a mouse head sample. PMID:23760762

Electromagnetic-Optical Coherence Tomography Guidance of Transbronchial Solitary Pulmonary Nodule Biopsy

DTIC Science & Technology

2017-12-01

AD_________________ (Leave blank) Award Number: W81XWH-13-1-0155 TITLE: Electromagnetic -Optical Coherence Tomography Guidance of Transbronchial...2. REPORT TYPE Final 3. DATES COVERED (From - To) 1 July 2013 - 30 Sep 2016 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Electromagnetic -Optical...SUPPLEMENTARY NOTES 14. ABSTRACT We present a novel high-resolution multimodality imaging platform utilizing CT and electromagnetic (EM) navigation for spatial

Long Coherence Length 193 nm Laser for High-Resolution Nano-Fabrication

DTIC Science & Technology

2008-06-27

in the non-linear optical up-converter, as well as specifying their interaction lengths, phase -matching angles, coatings, temperatures of operation...when optical path differences between interfering beams become comparable to the temporal coherence length of the source, the fringe contrast diminishes...switched, intracavity frequency doubled Nd:YAG laser drives an optical parametric oscillator (OPO) running at 710 nm. A portion of the 532 nm light

Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy

NASA Astrophysics Data System (ADS)

Zhou, Chao; Wang, Yihong; Aguirre, Aaron D.; Tsai, Tsung-Han; Cohen, David W.; Connolly, James L.; Fujimoto, James G.

2010-01-01

We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. 34 thyroid gland specimens are imaged from 17 patients, covering a spectrum of pathology ranging from normal thyroid to benign disease/neoplasms (multinodular colloid goiter, Hashimoto's thyroiditis, and follicular adenoma) and malignant thyroid tumors (papillary carcinoma and medullary carcinoma). Imaging is performed using an integrated OCT and OCM system, with <4 μm axial resolution (OCT and OCM), and 14 μm (OCT) and <2 μm (OCM) transverse resolution. The system allows seamless switching between low and high magnifications in a way similar to traditional microscopy. Good correspondence is observed between optical images and histological sections. Characteristic features that suggest malignant lesions, such as complex papillary architecture, microfollicules, psammomatous calcifications, or replacement of normal follicular architecture with sheets/nests of tumor cells, can be identified from OCT and OCM images and are clearly differentiable from normal or benign thyroid tissues. With further development of needle-based imaging probes, OCT and OCM could be promising techniques to use for the screening of thyroid nodules and to improve the diagnostic specificity of fine needle aspiration evaluation.

Ultra-dense WDM-PON delivering carrier-centralized Nyquist-WDM uplink with digital coherent detection.

PubMed

Dong, Ze; Yu, Jianjun; Chien, Hung-Chang; Chi, Nan; Chen, Lin; Chang, Gee-Kung

2011-06-06

We introduce an "ultra-dense" concept into next-generation WDM-PON systems, which transmits a Nyquist-WDM uplink with centralized uplink optical carriers and digital coherent detection for the future access network requiring both high capacity and high spectral efficiency. 80-km standard single mode fiber (SSMF) transmission of Nyquist-WDM signal with 13 coherent 25-GHz spaced wavelength shaped optical carriers individually carrying 100-Gbit/s polarization-multiplexing quadrature phase-shift keying (PM-QPSK) upstream data has been experimentally demonstrated with negligible transmission penalty. The 13 frequency-locked wavelengths with a uniform optical power level of -10 dBm and OSNR of more than 50 dB are generated from a single lightwave via a multi-carrier generator consists of an optical phase modulator (PM), a Mach-Zehnder modulator (MZM), and a WSS. Following spacing the carriers at the baud rate, sub-carriers are individually spectral shaped to form Nyquist-WDM. The Nyquist-WDM channels have less than 1-dB crosstalk penalty of optical signal-to-noise ratio (OSNR) at 2 × 10(-3) bit-error rate (BER). Performance of a traditional coherent optical OFDM scheme and its restrictions on symbol synchronization and power difference are also experimentally compared and studied.

The effect of jitter on the performance of space coherent optical communication system with Costas loop

NASA Astrophysics Data System (ADS)

Li, Xin; Hong, Yifeng; Wang, Jinfang; Liu, Yang; Sun, Xun; Li, Mi

2018-01-01

Numerous communication techniques and optical devices successfully applied in space optical communication system indicates a good portability of it. With this good portability, typical coherent demodulation technique of Costas loop can be easily adopted in space optical communication system. As one of the components of pointing error, the effect of jitter plays an important role in the communication quality of such system. Here, we obtain the probability density functions (PDF) of different jitter degrees and explain their essential effect on the bit error rate (BER) space optical communication system. Also, under the effect of jitter, we research the bit error rate of space coherent optical communication system using Costas loop with different system parameters of transmission power, divergence angle, receiving diameter, avalanche photodiode (APD) gain, and phase deviation caused by Costas loop. Through a numerical simulation of this kind of communication system, we demonstrate the relationship between the BER and these system parameters, and some corresponding methods of system optimization are presented to enhance the communication quality.

Optical coherence domain reflectometry guidewire

DOEpatents

Colston, Billy W.; Everett, Matthew; Da Silva, Luiz B.; Matthews, Dennis

2001-01-01

A guidewire with optical sensing capabilities is based on a multiplexed optical coherence domain reflectometer (OCDR), which allows it to sense location, thickness, and structure of the arterial walls or other intra-cavity regions as it travels through the body during minimally invasive medical procedures. This information will be used both to direct the guidewire through the body by detecting vascular junctions and to evaluate the nearby tissue. The guidewire contains multiple optical fibers which couple light from the proximal to distal end. Light from the fibers at the distal end of the guidewire is directed onto interior cavity walls via small diameter optics such as gradient index lenses and mirrored corner cubes. Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers, which are multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The guidewire can also be used in nonmedical applications.

Dental Optical Coherence Tomography

PubMed Central

Hsieh, Yao-Sheng; Ho, Yi-Ching; Lee, Shyh-Yuan; Chuang, Ching-Cheng; Tsai, Jui-che; Lin, Kun-Feng; Sun, Chia-Wei

2013-01-01

This review paper describes the applications of dental optical coherence tomography (OCT) in oral tissue images, caries, periodontal disease and oral cancer. The background of OCT, including basic theory, system setup, light sources, spatial resolution and system limitations, is provided. The comparisons between OCT and other clinical oral diagnostic methods are also discussed. PMID:23857261

Compact low-cost detection electronics for optical coherence imaging

PubMed Central

Akcay, A. C.; Lee, K. S.; Furenlid, L. R.; Costa, M. A.; Rolland, J. P.

2015-01-01

A compact and low-cost detection electronics scheme for optical coherence imaging is demonstrated. The performance of the designed electronics is analyzed in comparison to a commercial lock-in amplifier of equal bandwidth. Images of a fresh-onion sample are presented for each detection configuration. PMID:26617422

Spectral-domain optical coherence tomography for endoscopic imaging

NASA Astrophysics Data System (ADS)

Chen, Xiaodong; Li, Qiao; Li, Wanhui; Wang, Yi; Yu, Daoyin

2007-02-01

Optical coherence tomography (OCT) is an emerging cross-sectional imaging technology. It uses broadband light sources to achieve axial image resolutions on the few micron scale. OCT is widely applied to medical imaging, it can get cross-sectional image of bio-tissue (transparent and turbid) with non-invasion and non-touch. In this paper, the principle of OCT is presented and the crucial parameters of the system are discussed in theory. With analysis of different methods and medical endoscopic system's feature, a design which combines the spectral domain OCT (SDOCT) technique and endoscopy is put forward. SDOCT provides direct access to the spectrum of the optical signal. It is shown to provide higher imaging speed when compared to time domain OCT. At the meantime, a novel OCT probe which uses advanced micromotor to drive reflecting prism is designed according to alimentary tract endoscopic feature. A simple optical coherence tomography system has been developed based on a fiber-based Michelson interferometer and spectrometer. An experiment which uses motor to drive prism to realize rotating imaging is done. Images obtained with this spectral interferometer are presented. The results verify the feasibility of endoscopic optical coherence tomography system with rotating scan.

Optical manipulation of valley pseudospin

DOE PAGES

Ye, Ziliang; Sun, Dezheng; Heinz, Tony F.

2016-09-19

The coherent manipulation of spin and pseudospin underlies existing and emerging quantum technologies, including quantum communication and quantum computation. Valley polarization, associated with the occupancy of degenerate, but quantum mechanically distinct valleys in momentum space, closely resembles spin polarization and has been proposed as a pseudospin carrier for the future quantum electronics. Valley exciton polarization has been created in the transition metal dichalcogenide monolayers using excitation by circularly polarized light and has been detected both optically and electrically. In addition, the existence of coherence in the valley pseudospin has been identified experimentally. The manipulation of such valley coherence has, however,more » remained out of reach. In this paper, we demonstrate all-optical control of the valley coherence by means of the pseudomagnetic field associated with the optical Stark effect. Using below-bandgap circularly polarized light, we rotate the valley exciton pseudospin in monolayer WSe 2 on the femtosecond timescale. Both the direction and speed of the rotation can be manipulated optically by tuning the dynamic phase of excitons in opposite valleys. Finally, this study unveils the possibility of generation, manipulation, and detection of the valley pseudospin by coupling to photons.« less

Spectral domain optical coherence tomography imaging in optic disk pit associated with outer retinal dehiscence

PubMed Central

Wong, Chee Wai; Wong, Doric; Mathur, Ranjana

2014-01-01

A 37-year-old Bangladeshi male presented with an inferotemporal optic disk pit and serous macular detachment in the left eye. Imaging with spectral domain optical coherence tomography (OCT) revealed a multilayer macular schisis pattern with a small subfoveal outer retinal dehiscence. This case illustrates a rare phenotype of optic disk maculopathy with macular schisis and a small outer retinal layer dehiscence. Spectral domain OCT was a useful adjunct in delineating the retinal layers in optic disk pit maculopathy, and revealed a small area of outer retinal layer dehiscence that could only have been detected on high-resolution OCT. PMID:25349471

Terahertz Optical Gain Based on Intersubband Transitions in Optically-Pumped Semiconductor Quantum Wells: Coherent Pumped-Probe Interactions

NASA Technical Reports Server (NTRS)

Liu, Ansheng; Ning, Cun-Zheng

1999-01-01

Terahertz optical gain due to intersubband transitions in optically-pumped semiconductor quantum wells (QW's) is calculated nonperturbatively. We solve the pump- field-induced nonequilibrium distribution function for each subband of the QW system from a set of rate equations that include both intrasubband and intersubband relaxation processes. The gain arising from population inversion and stimulated Raman processes is calculated in a unified manner. We show that the coherent pump and signal wave interactions contribute significantly to the THz gain. Because of the optical Stark effect and pump-induced population redistribution, optical gain saturation at larger pump intensities is predicted.

Proposal for a multilayer read-only-memory optical disk structure.

PubMed

Ichimura, Isao; Saito, Kimihiro; Yamasaki, Takeshi; Osato, Kiyoshi

2006-03-10

Coherent interlayer cross talk and stray-light intensity of multilayer read-only-memory (ROM) optical disks are investigated. From results of scalar diffraction analyses, we conclude that layer separations above 10 microm are preferred in a system using a 0.85 numerical aperture objective lens in terms of signal quality and stability in focusing control. Disk structures are optimized to prevent signal deterioration resulting from multiple reflections, and appropriate detectors are determined to maintain acceptable stray-light intensity. In the experiment, quadrilayer and octalayer high-density ROM disks are prepared by stacking UV-curable films onto polycarbonate substrates. Data-to-clock jitters of < or = 7% demonstrate the feasibility of multilayer disk storage up to 200 Gbytes.

Ultrahigh-speed ultrahigh-resolution adaptive optics: optical coherence tomography system for in-vivo small animal retinal imaging

NASA Astrophysics Data System (ADS)

Jian, Yifan; Xu, Jing; Zawadzki, Robert J.; Sarunic, Marinko V.

2013-03-01

Small animal models of human retinal diseases are a critical component of vision research. In this report, we present an ultrahigh-resolution ultrahigh-speed adaptive optics optical coherence tomography (AO-OCT) system for small animal retinal imaging (mouse, fish, etc.). We adapted our imaging system to different types of small animals in accordance with the optical properties of their eyes. Results of AO-OCT images of small animal retinas acquired with AO correction are presented. Cellular structures including nerve fiber bundles, capillary networks and detailed double-cone photoreceptors are visualized.

FOXSI: Properties of optics and detectors for hard-X rays

NASA Astrophysics Data System (ADS)

Buitrago-Casas, Juan Camilo; Glesener, Lindsay; Christe, Steven; Krucker, Sam; Ishikawa, Shin-nosuke; Foster, Natalie

2015-04-01

The Focusing Optics X-ray Solar Imager (FOXSI) is a state-of-the-art direct focusing X-ray telescope designed to observe the Sun. This experiment completed its second flight onboard a sounding rocket last December 11, 2014 from the White Sands Missile Range in New Mexico. The optics use a set of iridium-coated nickel/cobalt mirrors made using a replication technique based on an electroformed perfect polished surface. Since this technique creates full shells that no need to be co-aligned with other segments, an angular resolution of up to ~5 arcsec is gotten. The FOXSI focal plane consists of seven double-sided strip detectors. Five Silicon and 2 CdTe detectors were used during the second flight.We present on various properties of Wolter-I optics that are applicable to solar HXR observation, including ray-tracing simulations of the single-bounce (“ghost ray”) patterns from sources outside the field of view and angular resolution for different source angles and effective area measurements of the FOXSI optics. We also present the detectors calibration results, paying attention to energy resolution (~0.5 keV), energy thresholds (~4-15 keV for Silicon and ~4-20 keV for CdTe detectors), and spatial coherence of these values over the entire detector.

Extinction measurement of dense media by an optical coherence tomography technique

NASA Astrophysics Data System (ADS)

Ago, Tomoki; Iwai, Toshiaki; Yokota, Ryoko

2016-10-01

The optical coherence tomography will make progress as the next stage toward a spectroscopic analysis technique. The spectroscopic analysis is based on the Beer-Lambert law. The absorption and scattering coefficients even for the dense medium can be measured by the Beer-Lambert law because the OCT can detect only the light keeping the coherency which propagated rectilinearly and retro-reflected from scatters. This study is concerned with the quantitative verification of Beer-Lambert law in the OCT imaging.

Chromatic dispersion estimation based on heterodyne detection for coherent optical communication systems

NASA Astrophysics Data System (ADS)

Li, Yong; Yang, Aiying; Guo, Peng; Qiao, Yaojun; Lu, Yueming

2018-01-01

We propose an accurate and nondata-aided chromatic dispersion (CD) estimation method involving the use of the cross-correlation function of two heterodyne detection signals for coherent optical communication systems. Simulations are implemented to verify the feasibility of the proposed method for 28-GBaud coherent systems with different modulation formats. The results show that the proposed method has high accuracy for measuring CD and has good robustness against laser phase noise, amplified spontaneous emission noise, and nonlinear impairments.

Performance analysis of a coherent free space optical communication system based on experiment.

PubMed

Cao, Jingtai; Zhao, Xiaohui; Liu, Wei; Gu, Haijun

2017-06-26

Based on our previous study and designed experimental AO system with a 97-element continuous surface deformable mirror, we conduct the performance analysis of a coherent free space optical communication (FSOC) system for mixing efficiency (ME), bit error rate (BER) and outage probability under different Greenwood frequency and atmospheric coherent length. The results show that the influence of the atmospheric temporal characteristics on the performance is slightly stronger than that of the spatial characteristics when the receiving aperture and the number of sub-apertures are given. This analysis result provides a reference for the design of the coherent FSOC system.

Laser Controlled Tunneling in a Vertical Optical Lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beaufils, Q.; Tackmann, G.; Wang, X.

2011-05-27

Raman laser pulses are used to induce coherent tunneling between neighboring sites of a vertical 1D optical lattice. Such tunneling occurs when the detuning of a probe laser from the atomic transition frequency matches multiples of the Bloch frequency, allowing for a spectroscopic control of the coupling between Wannier-Stark (WS) states. In particular, we prepare coherent superpositions of WS states of adjacent sites, and investigate the coherence time of these superpositions by realizing a spatial interferometer. This scheme provides a powerful tool for coherent manipulation of external degrees of freedom of cold atoms, which is a key issue for quantummore » information processing.« less

Time-reversed wave mixing in nonlinear optics

PubMed Central

Zheng, Yuanlin; Ren, Huaijin; Wan, Wenjie; Chen, Xianfeng

2013-01-01

Time-reversal symmetry is important to optics. Optical processes can run in a forward or backward direction through time when such symmetry is preserved. In linear optics, a time-reversed process of laser emission can enable total absorption of coherent light fields inside an optical cavity of loss by time-reversing the original gain medium. Nonlinearity, however, can often destroy such symmetry in nonlinear optics, making it difficult to study time-reversal symmetry with nonlinear optical wave mixings. Here we demonstrate time-reversed wave mixings for optical second harmonic generation (SHG) and optical parametric amplification (OPA) by exploring this well-known but underappreciated symmetry in nonlinear optics. This allows us to observe the annihilation of coherent beams. Our study offers new avenues for flexible control in nonlinear optics and has potential applications in efficient wavelength conversion, all-optical computing. PMID:24247906

Measurement of ultrasonic fields in transparent media using a scanning differential interferometer

NASA Technical Reports Server (NTRS)

Dockery, G. D.; Claus, R. O.

1983-01-01

An experimental system for the detection of three dimensional acoustic fields in optically transparent media using a dual beam differential interferometer is described. In this system, two coherent, parallel, focused laser beams are passed through the specimen and the interference fringe pattern which results when these beams are combined shifts linearly by an amount which is related to the optical pathlength difference between the two beams. It is shown that for small signals, the detector output is directly proportional to the amplitude of the acoustic field integrated along the optical beam path through the specimen. A water tank and motorized optical platform were constructed to allow these dual beams to be scanned through an ultrasonic field generated by a piezoelectric transducer at various distances from the transducer. Scan data for the near, Fresnel, and far zones of a uniform, circular transducer are presented and an algorithm for constructing the radial field profile from this integrated optical data, assuming cylindrical symmetry, is described.

Speckle size in optical Fourier domain imaging

NASA Astrophysics Data System (ADS)

Lamouche, G.; Vergnole, S.; Bisaillon, C.-E.; Dufour, M.; Maciejko, R.; Monchalin, J.-P.

2007-06-01

As in conventional time-domain optical coherence tomography (OCT), speckle is inherent to any Optical Fourier Domain Imaging (OFDI) of biological tissue. OFDI is also known as swept-source OCT (SS-OCT). The axial speckle size is mainly determined by the OCT resolution length and the transverse speckle size by the focusing optics illuminating the sample. There is also a contribution from the sample related to the number of scatterers contained within the probed volume. In the OFDI data processing, there is some liberty in selecting the range of wavelengths used and this allows variation in the OCT resolution length. Consequently the probed volume can be varied. By performing measurements on an optical phantom with a controlled density of discrete scatterers and by changing the probed volume with different range of wavelengths in the OFDI data processing, there is an obvious change in the axial speckle size, but we show that there is also a less obvious variation in the transverse speckle size. This work contributes to a better understanding of speckle in OCT.

Frequency-time coherence for all-optical sampling without optical pulse source

PubMed Central

Preußler, Stefan; Raoof Mehrpoor, Gilda; Schneider, Thomas

2016-01-01

Sampling is the first step to convert an analogue optical signal into a digital electrical signal. The latter can be further processed and analysed by well-known electrical signal processing methods. Optical pulse sources like mode-locked lasers are commonly incorporated for all-optical sampling, but have several drawbacks. A novel approach for a simple all-optical sampling is to utilise the frequency-time coherence of each signal. The method is based on only using two coupled modulators driven with an electrical sine wave. Since no optical source is required, a simple integration in appropriate platforms, such as Silicon Photonics might be possible. The presented method grants all-optical sampling with electrically tunable bandwidth, repetition rate and time shift. PMID:27687495

A new real-time non-coherent to coherent light image converter - The hybrid field effect liquid crystal light valve

NASA Technical Reports Server (NTRS)

Grinberg, J.; Jacobson, A.; Bleha, W.; Miller, L.; Fraas, L.; Boswell, D.; Myer, G.

1975-01-01

A new, high-performance device has been developed for application to real-time coherent optical data processing. The new device embodies a CdS photoconductor, a CdTe light-absorbing layer, a dielectric mirror, and a liquid crystal layer sandwiched between indium-tin-oxide transparent electrodes deposited on optical quality glass flats. The noncoherent image is directed onto the photoconductor; this reduces the impedance of the photoconductor, thereby switching the ac voltage that is impressed across the electrodes onto the liquid crystal to activate the device. The liquid crystal is operated in a hybrid field effect mode. It utilizes the twisted nematic effect to create a dark off-state and the optical birefringence effect to create the bright on-state. The liquid crystal modulates the polarization of the coherent read-out light so an analyzer must be used to create an intensity modulated output beam.

Coherent Control to Prepare an InAs Quantum Dot for Spin-Photon Entanglement

NASA Astrophysics Data System (ADS)

Webster, L. A.; Truex, K.; Duan, L.-M.; Steel, D. G.; Bracker, A. S.; Gammon, D.; Sham, L. J.

2014-03-01

We optically generated an electronic state in a single InAs /GaAs self-assembled quantum dot that is a precursor to the deterministic entanglement of the spin of the electron with an emitted photon in the proposal of W. Yao, R.-B. Liu, and L. J. Sham [Phys. Rev. Lett. 95, 030504 (2005).]. A superposition state is prepared by optical pumping to a pure state followed by an initial pulse. By modulating the subsequent pulse arrival times and precisely controlling them using interferometric measurement of path length differences, we are able to implement a coherent control technique to selectively drive exactly one of the two components of the superposition to the ground state. This optical transition contingent on spin was driven with the same broadband pulses that created the superposition through the use of a two pulse coherent control sequence. A final pulse affords measurement of the coherence of this "preentangled" state.

Coherent all-optical control of ultracold atoms arrays in permanent magnetic traps.

PubMed

Abdelrahman, Ahmed; Mukai, Tetsuya; Häffner, Hartmut; Byrnes, Tim

2014-02-10

We propose a hybrid architecture for quantum information processing based on magnetically trapped ultracold atoms coupled via optical fields. The ultracold atoms, which can be either Bose-Einstein condensates or ensembles, are trapped in permanent magnetic traps and are placed in microcavities, connected by silica based waveguides on an atom chip structure. At each trapping center, the ultracold atoms form spin coherent states, serving as a quantum memory. An all-optical scheme is used to initialize, measure and perform a universal set of quantum gates on the single and two spin-coherent states where entanglement can be generated addressably between spatially separated trapped ultracold atoms. This allows for universal quantum operations on the spin coherent state quantum memories. We give detailed derivations of the composite cavity system mediated by a silica waveguide as well as the control scheme. Estimates for the necessary experimental conditions for a working hybrid device are given.

Excitonic linewidth and coherence lifetime in monolayer transition metal dichalcogenides

DOE PAGES

Selig, Malte; Berghäuser, Gunnar; Raja, Archana; ...

2016-11-07

Atomically thin transition metal dichalcogenides are direct-gap semiconductors with strong light–matter and Coulomb interactions. The latter accounts for tightly bound excitons, which dominate their optical properties. Besides the optically accessible bright excitons, these systems exhibit a variety of dark excitonic states. They are not visible in the optical spectra, but can strongly influence the coherence lifetime and the linewidth of the emission from bright exciton states. We investigate the microscopic origin of the excitonic coherence lifetime in two representative materials (WS 2 and MoSe 2) through a study combining microscopic theory with spectroscopic measurements. We also show that the excitonicmore » coherence lifetime is determined by phonon-induced intravalley scattering and intervalley scattering into dark excitonic states. Particularly, we identify exciton relaxation processes involving phonon emission into lower-lying dark states that are operative at all temperatures, in WS 2.« less

Optical Coherence Microscopy

NASA Astrophysics Data System (ADS)

Aguirre, Aaron D.; Zhou, Chao; Lee, Hsiang-Chieh; Ahsen, Osman O.; Fujimoto, James G.

Cellular imaging of human tissues remains an important advance for many clinical applications of optical coherence tomography (OCT). Imaging cells with traditional OCT systems has not been possible due to the limited transverse resolution of such techniques. Optical coherence microscopy (OCM) refers to OCT methods that achieve high transverse resolution to visualize cells and subcellular features. This chapter provides a comprehensive discussion of the rationale for cellular imaging in human tissues as well as a review of the key technological advances required to achieve it. Time domain and Fourier domain OCM approaches are described with an emphasis on state of the art system designs, including miniaturized endoscopic imaging probes. Clinical applications are discussed and multiple examples of cellular imaging in human tissues are provided.

Mechanical design of thin-film diamond crystal mounting apparatus for coherence preservation hard x-ray optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shu, Deming, E-mail: shu@aps.anl.gov; Shvyd’ko, Yuri V.; Stoupin, Stanislav

2016-07-27

A new thin-film diamond crystal mounting apparatus has been designed at the Advanced Photon Source (APS) for coherence preservation hard x-ray optics with optimized thermal contact and minimized crystal strain. This novel mechanical design can be applied to new development in the field of: x-ray optics cavities for hard x-ray free-electron laser oscillators (XFELOs), self-seeding monochromators for hard x-ray free-electron laser (XFEL) with high average thermal loading, high heat load diamond crystal monochromators and beam-sharing/beam-split-and-delay devices for XFEL facilities and future upgraded high-brightness coherent x-ray source in the MBA lattice configuration at the APS.

Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti.

PubMed

Kim, Sang Jin; Yang, Jianlong; Liu, Gangjun; Huang, David; Campbell, J Peter

2018-04-01

Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may be used as noninvasive imaging modalities for IP and similar retinal vascular disorders in supine young children. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:273-275.]. Copyright 2018, SLACK Incorporated.

Common-path low-coherence interferometry fiber-optic sensor guided microincision

PubMed Central

Zhang, Kang; Kang, Jin U.

2011-01-01

We propose and demonstrate a common-path low-coherence interferometry (CP-LCI) fiber-optic sensor guided precise microincision. The method tracks the target surface and compensates the tool-to-surface relative motion with better than ±5 μm resolution using a precision micromotor connected to the tool tip. A single-fiber distance probe integrated microdissector was used to perform an accurate 100 μm incision into the surface of an Intralipid phantom. The CP-LCI guided incision quality in terms of depth was evaluated afterwards using three-dimensional Fourier-domain optical coherence tomography imaging, which showed significant improvement of incision accuracy compared to free-hand-only operations. PMID:21950912

Development of speckle-free channel-cut crystal optics using plasma chemical vaporization machining for coherent x-ray applications.

PubMed

Hirano, Takashi; Osaka, Taito; Sano, Yasuhisa; Inubushi, Yuichi; Matsuyama, Satoshi; Tono, Kensuke; Ishikawa, Tetsuya; Yabashi, Makina; Yamauchi, Kazuto

2016-06-01

We have developed a method of fabricating speckle-free channel-cut crystal optics with plasma chemical vaporization machining, an etching method using atmospheric-pressure plasma, for coherent X-ray applications. We investigated the etching characteristics to silicon crystals and achieved a small surface roughness of less than 1 nm rms at a removal depth of >10 μm, which satisfies the requirements for eliminating subsurface damage while suppressing diffuse scattering from rough surfaces. We applied this method for fabricating channel-cut Si(220) crystals for a hard X-ray split-and-delay optical system and confirmed that the crystals provided speckle-free reflection profiles under coherent X-ray illumination.

Fingerprint imaging from the inside of a finger with full-field optical coherence tomography

PubMed Central

Auksorius, Egidijus; Boccara, A. Claude

2015-01-01

Imaging below fingertip surface might be a useful alternative to the traditional fingerprint sensing since the internal finger features are more reliable than the external ones. One of the most promising subsurface imaging technique is optical coherence tomography (OCT), which, however, has to acquire 3-D data even when a single en face image is required. This makes OCT inherently slow for en face imaging and produce unnecessary large data sets. Here we demonstrate that full-field optical coherence tomography (FF-OCT) can be used to produce en face images of sweat pores and internal fingerprints, which can be used for the identification purposes. PMID:26601009

Coherent Perfect Rotation: The conservative analogue of CPA

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Dawson, Nathan; Andrews, James

2012-06-01

The two classes of conservative, linear, optical rotary effects (optical activity and Faraday rotation) are distinguished by their behavior under time reversal. In analogy with coherent perfect absorption (CPA) resonances, where counter-propagating light fields are completely converted into other degrees of freedom, we show that in a linear conservative medium only time-odd (Faraday) rotation is capable of coherent perfect rotation, by which we mean the complete transfer of any arbitrarily oriented polarization of light into the other orthogonal polarization via the application of phased counter-propagating light fields. This contributes to the understanding of the importance of time reversal symmetry in perfect mode conversion that may be of use in optical device design.

Faithful Solid State Optical Memory with Dynamically Decoupled Spin Wave Storage

NASA Astrophysics Data System (ADS)

Lovrić, Marko; Suter, Dieter; Ferrier, Alban; Goldner, Philippe

2013-07-01

We report a high fidelity optical memory in which dynamical decoupling is used to extend the storage time. This is demonstrated in a rare-earth doped crystal in which optical coherences were transferred to nuclear spin coherences and then protected against environmental noise by dynamical decoupling, leading to storage times of up to 4.2 ms. An interference experiment shows that relative phases of input pulses are preserved through the whole storage and retrieval process with a visibility ≈1, demonstrating the usefulness of dynamical decoupling for extending the storage time of quantum memories. We also show that dynamical decoupling sequences insensitive to initial spin coherence increase retrieval efficiency.

Faithful solid state optical memory with dynamically decoupled spin wave storage.

PubMed

Lovrić, Marko; Suter, Dieter; Ferrier, Alban; Goldner, Philippe

2013-07-12

We report a high fidelity optical memory in which dynamical decoupling is used to extend the storage time. This is demonstrated in a rare-earth doped crystal in which optical coherences were transferred to nuclear spin coherences and then protected against environmental noise by dynamical decoupling, leading to storage times of up to 4.2 ms. An interference experiment shows that relative phases of input pulses are preserved through the whole storage and retrieval process with a visibility ≈1, demonstrating the usefulness of dynamical decoupling for extending the storage time of quantum memories. We also show that dynamical decoupling sequences insensitive to initial spin coherence increase retrieval efficiency.

Development of at-wavelength metrology for x-ray optics at the ALS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yashchuk, Valeriy V.; Goldberg, Kenneth A.; Yuan, Sheng

2010-07-09

The comprehensive realization of the exciting advantages of new third- and forth-generation synchrotron radiation light sources requires concomitant development of reflecting and diffractive x-ray optics capable of micro- and nano-focusing, brightness preservation, and super high resolution. The fabrication, tuning, and alignment of the optics are impossible without adequate metrology instrumentation, methods, and techniques. While the accuracy of ex situ optical metrology at the Advanced Light Source (ALS) has reached a state-of-the-art level, wavefront control on beamlines is often limited by environmental and systematic alignment factors, and inadequate in situ feedback. At ALS beamline 5.3.1, we are developing broadly applicable, high-accuracy,more » in situ, at-wavelength wavefront measurement techniques to surpass 100-nrad slope measurement accuracy for Kirkpatrick-Baez (KB) mirrors. The at-wavelength methodology we are developing relies on a series of tests with increasing accuracy and sensitivity. Geometric Hartmann tests, performed with a scanning illuminated sub-aperture determine the wavefront slope across the full mirror aperture. Shearing interferometry techniques use coherent illumination and provide higher sensitivity wavefront measurements. Combining these techniques with high precision optical metrology and experimental methods will enable us to provide in situ setting and alignment of bendable x-ray optics to realize diffraction-limited, sub 50 nm focusing at beamlines. We describe here details of the metrology beamline endstation, the x-ray beam diagnostic system, and original experimental techniques that have already allowed us to precisely set a bendable KB mirror to achieve a focused spot size of 150 nm.« less

Mapping Winter Wheat with Multi-Temporal SAR and Optical Images in an Urban Agricultural Region

PubMed Central

Zhou, Tao; Pan, Jianjun; Zhang, Peiyu; Wei, Shanbao; Han, Tao

2017-01-01

Winter wheat is the second largest food crop in China. It is important to obtain reliable winter wheat acreage to guarantee the food security for the most populous country in the world. This paper focuses on assessing the feasibility of in-season winter wheat mapping and investigating potential classification improvement by using SAR (Synthetic Aperture Radar) images, optical images, and the integration of both types of data in urban agricultural regions with complex planting structures in Southern China. Both SAR (Sentinel-1A) and optical (Landsat-8) data were acquired, and classification using different combinations of Sentinel-1A-derived information and optical images was performed using a support vector machine (SVM) and a random forest (RF) method. The interference coherence and texture images were obtained and used to assess the effect of adding them to the backscatter intensity images on the classification accuracy. The results showed that the use of four Sentinel-1A images acquired before the jointing period of winter wheat can provide satisfactory winter wheat classification accuracy, with an F1 measure of 87.89%. The combination of SAR and optical images for winter wheat mapping achieved the best F1 measure–up to 98.06%. The SVM was superior to RF in terms of the overall accuracy and the kappa coefficient, and was faster than RF, while the RF classifier was slightly better than SVM in terms of the F1 measure. In addition, the classification accuracy can be effectively improved by adding the texture and coherence images to the backscatter intensity data. PMID:28587066

Characterization of human scalp hairs by optical low-coherence reflectometry

NASA Astrophysics Data System (ADS)

Wang, X. J.; Milner, T. E.; Dhond, R. P.; Sorin, W. V.; Newton, S. A.; Nelson, J. S.

1995-03-01

Optical low-coherence reflectometry is used to investigate the internal structure and optical properties of human scalp hair. Regardless of hair color, the refractive index of the cortical region remains within the range of 1.56-1.59. The amplitude of the backscattered infrared light coupled into different-colored hair confirms the relative melanin content. Discontinuities in the refractive index permit identification of distinct structural layers within the hair shaft.

Distributed strain measurements using fiber Bragg gratings in small-diameter optical fiber and low-coherence reflectometry.

PubMed

Coric, Dragan; Lai, Marco; Botsis, John; Luo, Aiping; Limberger, Hans G

2010-12-06

Optical low coherence reflectometry and fiber Bragg gratings written in small diameter (50 micrometer) optical fibers were used for measurements of non-homogenous internal strain fields inside an epoxy specimen with sub-grating length resolution. The results were compared with measurements using Fiber Bragg gratings in standard size (125 micrometer) single mode fibers and show that smaller fibers are less intrusive at stress heterogeneities.

Coherent direct sequence optical code multiple access encoding-decoding efficiency versus wavelength detuning.

PubMed

Pastor, D; Amaya, W; García-Olcina, R; Sales, S

2007-07-01

We present a simple theoretical model of and the experimental verification for vanishing of the autocorrelation peak due to wavelength detuning on the coding-decoding process of coherent direct sequence optical code multiple access systems based on a superstructured fiber Bragg grating. Moreover, the detuning vanishing effect has been explored to take advantage of this effect and to provide an additional degree of multiplexing and/or optical code tuning.

Fourier phase in Fourier-domain optical coherence tomography

PubMed Central

Uttam, Shikhar; Liu, Yang

2015-01-01

Phase of an electromagnetic wave propagating through a sample-of-interest is well understood in the context of quantitative phase imaging in transmission-mode microscopy. In the past decade, Fourier-domain optical coherence tomography has been used to extend quantitative phase imaging to the reflection-mode. Unlike transmission-mode electromagnetic phase, however, the origin and characteristics of reflection-mode Fourier phase are poorly understood, especially in samples with a slowly varying refractive index. In this paper, the general theory of Fourier phase from first principles is presented, and it is shown that Fourier phase is a joint estimate of subresolution offset and mean spatial frequency of the coherence-gated sample refractive index. It is also shown that both spectral-domain phase microscopy and depth-resolved spatial-domain low-coherence quantitative phase microscopy are special cases of this general theory. Analytical expressions are provided for both, and simulations are presented to explain and support the theoretical results. These results are further used to show how Fourier phase allows the estimation of an axial mean spatial frequency profile of the sample, along with depth-resolved characterization of localized optical density change and sample heterogeneity. Finally, a Fourier phase-based explanation of Doppler optical coherence tomography is also provided. PMID:26831383

Telephoto axicon

NASA Astrophysics Data System (ADS)

Burvall, Anna; Goncharov, Alexander; Dainty, Chris

2005-09-01

The axicon is an optical element which creates a narrow focal line along the optical axis, unlike the single focal point produced by a lens. The long and precisely defined axicon focal line is used e.g. in alignment, or to extend the depth of focus of existing methods such as optical coherence tomography or light sectioning. Axicons are generally manufactured as refractive cones or diffractive circular gratings. They are also made as lens systems or doublet lenses, which are easier to produce. We present a design in the form of a reflective-refractive single-element device with annular aperture. This very compact system has only two surfaces, which can be spherical or aspheric depending on the quality required of the focal line. Both surfaces have reflective coatings at specific zones, providing an annular beam suitable for generating extended focal lines. One draw-back of a normal axicon is its sensitivity to the angle of illumination. Even for relatively small angles, astigmatism will broaden the focus and give it an asteroid shape. For our design, with spherical surfaces concentric about the center of the entrance pupil, the focal line remains unchanged in off-axis illumination.

Holographic illuminator for synchrotron-based projection lithography systems

DOEpatents

Naulleau, Patrick P.

2005-08-09

The effective coherence of a synchrotron beam line can be tailored to projection lithography requirements by employing a moving holographic diffuser and a stationary low-cost spherical mirror. The invention is particularly suited for use in an illuminator device for an optical image processing system requiring partially coherent illumination. The illuminator includes: (1) a synchrotron source of coherent or partially coherent radiation which has an intrinsic coherence that is higher than the desired coherence, (2) a holographic diffuser having a surface that receives incident radiation from said source, (3) means for translating the surface of the holographic diffuser in two dimensions along a plane that is parallel to the surface of the holographic diffuser wherein the rate of the motion is fast relative to integration time of said image processing system; and (4) a condenser optic that re-images the surface of the holographic diffuser to the entrance plane of said image processing system.

Identification of muscle necrosis in the mdx mouse model of Duchenne muscular dystrophy using three-dimensional optical coherence tomography

NASA Astrophysics Data System (ADS)

Klyen, Blake R.; Shavlakadze, Thea; Radley-Crabb, Hannah G.; Grounds, Miranda D.; Sampson, David D.

2011-07-01

Three-dimensional optical coherence tomography (3D-OCT) was used to image the structure and pathology of skeletal muscle tissue from the treadmill-exercised mdx mouse model of human Duchenne muscular dystrophy. Optical coherence tomography (OCT) images of excised muscle samples were compared with co-registered hematoxylin and eosin-stained and Evans blue dye fluorescence histology. We show, for the first time, structural 3D-OCT images of skeletal muscle dystropathology well correlated with co-located histology. OCT could identify morphological features of interest and necrotic lesions within the muscle tissue samples based on intrinsic optical contrast. These findings demonstrate the utility of 3D-OCT for the evaluation of small-animal skeletal muscle morphology and pathology, particularly for studies of mouse models of muscular dystrophy.

The detection of objects in a turbid underwater medium using orbital angular momentum (OAM)

NASA Astrophysics Data System (ADS)

Cochenour, Brandon; Rodgers, Lila; Laux, Alan; Mullen, Linda; Morgan, Kaitlyn; Miller, Jerome K.; Johnson, Eric G.

2017-05-01

We present an investigation of the optical property of orbital angular momentum (OAM) for use in the detection of objects obscured by a turbid underwater channel. In our experiment, a target is illuminated by a Gaussian beam. An optical vortex is formed by passing the object-reflected and backscattered light through a diffractive spiral phase plate at the receiver, which allows for the spatial separation of coherent and non-coherent light. This provides a method for discriminating target from environment. Initial laboratory results show that the ballistic target return can be detected 2-3 orders of magnitude below the backscatter clutter level. Furthermore, the detection of this coherent component is accomplished with the use of a complicated optical heterodyning scheme. The results suggest new optical sensing techniques for underwater imaging or LIDAR.