Bioinformatics tools for the analysis of NMR metabolomics studies focused on the identification of clinically relevant biomarkers.

PubMed

Puchades-Carrasco, Leonor; Palomino-Schätzlein, Martina; Pérez-Rambla, Clara; Pineda-Lucena, Antonio

2016-05-01

Metabolomics, a systems biology approach focused on the global study of the metabolome, offers a tremendous potential in the analysis of clinical samples. Among other applications, metabolomics enables mapping of biochemical alterations involved in the pathogenesis of diseases, and offers the opportunity to noninvasively identify diagnostic, prognostic and predictive biomarkers that could translate into early therapeutic interventions. Particularly, metabolomics by Nuclear Magnetic Resonance (NMR) has the ability to simultaneously detect and structurally characterize an abundance of metabolic components, even when their identities are unknown. Analysis of the data generated using this experimental approach requires the application of statistical and bioinformatics tools for the correct interpretation of the results. This review focuses on the different steps involved in the metabolomics characterization of biofluids for clinical applications, ranging from the design of the study to the biological interpretation of the results. Particular emphasis is devoted to the specific procedures required for the processing and interpretation of NMR data with a focus on the identification of clinically relevant biomarkers. © The Author 2015. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

A Military-Relevant Model of Closed Concussive Head Injury: Longitudinal Studies Characterizing and Validating Single and Repetitive mTBI

DTIC Science & Technology

2014-10-01

Research Program (CCCRP). Provided in this Year 2 Annual Report are the results of our Phase I studies focused on characterizing the neuropathologic...effects of a single concussive impact to repeated concussive impacts using the PCI model. Phase I studies have been completed and these results set...the foundation for Phase II studies designed to evaluate the effects of repeated concussions that occur prior to and after the resolution of the

Laser-assisted solar-cell metallization processing

NASA Technical Reports Server (NTRS)

Dutta, S.

1984-01-01

A photolytic metal deposition system using a focused continuous wave ultraviolet laser, a photolytic metal deposition system using a mask and ultraviolet flood illumination, and a pyrolytic metal deposition system using a focused continuous wave laser were studied. Fabrication of solar cells, as well as characterization to determine the effects of transient heat on solar cell junctions were investigated.

A Study of Flow Theory in the Foreign Language Classroom

ERIC Educational Resources Information Center

Egbert, Joy

2004-01-01

This article focuses on the relationship between flow experiences and language learning. Flow Theory suggests that flow experiences (characterized by a balance between challenge and skills and by a person's interest, control, and focused attention during a task) can lead to optimal learning. This theory has not yet been tested in the area of…

Focus: Surface Characterization.

ERIC Educational Resources Information Center

Winograd, Nicholas

1985-01-01

The 38th Annual Summer Symposium on Analytical Chemistry (June 18-20, 1985) focused on the surface characterization of catalytic and electronic materials. Highlights of the symposium are provided, including presentations that considered lasers and microscopy. (JN)

An Optical Method for the In-Vivo Characterization of the Biomechanical Response of the Right Ventricle.

PubMed

Soltani, A; Lahti, J; Järvelä, K; Curtze, S; Laurikka, J; Hokka, M; Kuokkala, V-T

2018-05-01

The intraoperative in-vivo mechanical function of the left ventricle has been studied thoroughly using echocardiography in the past. However, due to technical and anatomical issues, the ultrasound technology cannot easily be focused on the right side of the heart during open-heart surgery, and the function of the right ventricle during the intervention remains largely unexplored. We used optical imaging and digital image correlation for the characterization of the right ventricle motion and deformation during open-heart surgery. This work is a pilot study focusing on one patient only with the aim of establishing the framework for long term research. These experiments show that optical imaging and the analysis of the images can be used to obtain similar parameters, and partly at higher accuracy, for describing the mechanical functioning of the heart as the ultrasound technology. This work describes the optical imaging based method to characterize the mechanical response of the heart in-vivo, and offers new insight into the mechanical function of the right ventricle.

Characterizing Resilience and Growth Among Soldiers: A Trajectory Study

DTIC Science & Technology

2013-10-01

research and practices. In R.A. McMackin, T. M. Keane, E. Newman , & J. M. Fogler (Eds.), Toward an integrated approach to trauma focused therapy: Placing...perspective on research and practices. In R.A. McMackin, T. M. Keane, E. Newman , & J. M. Fogler (Eds.), Toward an integrated approach to trauma focused...on research and practices. In R.A. McMackin, T. M. Keane, E. Newman , & J. M. Fogler (Eds.), Toward an integrated approach to trauma focused therapy

Preparation for Scaling Studies of Ice-Crystal Icing at the NRC Research Altitude Test Facility

NASA Technical Reports Server (NTRS)

Struk, Peter M.; Bencic, Timothy J.; Tsao, Jen-Ching; Fuleki, Dan; Knezevici, Daniel C.

2013-01-01

This paper describes experiments conducted at the National Research Council (NRC) of Canadas Research Altitiude Test Facility between March 26 and April 11, 2012. The tests, conducted collaboratively between NASA and NRC, focus on three key aspects in preparation for later scaling work to be conducted with a NACA 0012 airfoil model in the NRC Cascade rig: (1) cloud characterization, (2) scaling model development, and (3) ice-shape profile measurements. Regarding cloud characterization, the experiments focus on particle spectra measurements using two shadowgraphy methods, cloud uniformity via particle scattering from a laser sheet, and characterization of the SEA Multi-Element probe. Overviews of each aspect as well as detailed information on the diagnostic method are presented. Select results from the measurements and interpretation are presented which will help guide future work.

Optimizing surveillance for South American origin influenza A viruses along the United States Gulf Coast through genomic characterization of isolates from blue-winged teal (Anas discors)

USDA-ARS?s Scientific Manuscript database

Relative to research focused on intercontinental viral exchange between Eurasia and North America, less attention has been directed towards understanding the redistribution of influenza A viruses (IAVs) by wild birds between North America and South America. In this study, we genomically characterize...

Characterizing the nature of home care work and occupational hazards: a developmental intervention study.

PubMed

Markkanen, Pia; Quinn, Margaret; Galligan, Catherine; Sama, Susan; Brouillette, Natalie; Okyere, Daniel

2014-04-01

Home care (HC) aide is the fastest growing occupation, yet job hazards are under-studied. This study documents the context of HC aide work, characterizes occupational safety and health (OSH) hazards, and identifies preventive interventions using qualitative methods. We conducted 12 focus groups among aides and 26 in-depth interviews comprising 15 HC agency, union, and insurance company representatives as well as 11 HC recipients in Massachusetts. All focus groups and interviews were audio-recorded, transcribed, and coded with NVIVO software. Major OSH concerns were musculoskeletal disorders from client care tasks and verbal abuse. Performing tasks beyond specified job duties may be an OSH risk factor. HC aides' safety and clients' safety are closely linked. Client handling devices, client evaluation, care plan development, and training are key interventions for both aides' and clients' safety. Promoting OSH in HC is essential for maintaining a viable workforce. © 2013 Wiley Periodicals, Inc.

Three-dimensional characterization of pigment dispersion in dried paint films using focused ion beam-scanning electron microscopy.

PubMed

Lin, Jui-Ching; Heeschen, William; Reffner, John; Hook, John

2012-04-01

The combination of integrated focused ion beam-scanning electron microscope (FIB-SEM) serial sectioning and imaging techniques with image analysis provided quantitative characterization of three-dimensional (3D) pigment dispersion in dried paint films. The focused ion beam in a FIB-SEM dual beam system enables great control in slicing paints, and the sectioning process can be synchronized with SEM imaging providing high quality serial cross-section images for 3D reconstruction. Application of Euclidean distance map and ultimate eroded points image analysis methods can provide quantitative characterization of 3D particle distribution. It is concluded that 3D measurement of binder distribution in paints is effective to characterize the order of pigment dispersion in dried paint films.

In situ focus characterization by ablation technique to enable optics alignment at an XUV FEL source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerasimova, N.; Dziarzhytski, S.; Weigelt, H.

2013-06-15

In situ focus characterization is demonstrated by working at an extreme ultraviolet (XUV) free-electron laser source using ablation technique. Design of the instrument reported here allows reaching a few micrometres resolution along with keeping the ultrahigh vacuum conditions and ensures high-contrast visibility of ablative imprints on optically transparent samples, e.g., PMMA. This enables on-line monitoring of the beam profile changes and thus makes possible in situ alignment of the XUV focusing optics. A good agreement between focal characterizations retrieved from in situ inspection of ablative imprints contours and from well-established accurate ex situ analysis with Nomarski microscope has been observedmore » for a typical micro-focus experiment.« less

Entrepreneurial Decision Making and Institutional Governance within the Academy: A Case Study

ERIC Educational Resources Information Center

French, Edward F.

2011-01-01

This case study explored the relationship between entrepreneurial decision making and optimal institutional governance. The study focused on a single institution, characterized as a small, tuition-driven, private institution. Twelve participants were interviewed in the study, equally divided between members of the faculty and of the…

Characterization and Analysis of a Multicolor Quantum Well Infrared Photodetector

DTIC Science & Technology

2006-06-01

and characterization of performance of a newly designed, multicolor quantum well infrared photodetector ( QWIP ). Specifically, it focuses on a detector...quantum well infrared detectors makes them suitable for use in the field. 15. NUMBER OF PAGES 67 14. SUBJECT TERMS Quantum Well, QWIP , Three...characterization of performance of a newly designed, multicolor quantum well infrared photodetector ( QWIP ). Specifically, it focuses on a detector

Focus characterization at an X-ray free-electron laser by coherent scattering and speckle analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sikorski, Marcin; Song, Sanghoon; Schropp, Andreas

2015-04-14

X-ray focus optimization and characterization based on coherent scattering and quantitative speckle size measurements was demonstrated at the Linac Coherent Light Source. Its performance as a single-pulse free-electron laser beam diagnostic was tested for two typical focusing configurations. The results derived from the speckle size/shape analysis show the effectiveness of this technique in finding the focus' location, size and shape. In addition, its single-pulse compatibility enables users to capture pulse-to-pulse fluctuations in focus properties compared with other techniques that require scanning and averaging.

Detail and gestalt focus in individuals with optimal outcomes from Autism Spectrum Disorders

PubMed Central

Fitch, Allison; Fein, Deborah A.; Eigsti, Inge-Marie

2015-01-01

Individuals with high-functioning autism (HFA) have a cognitive style that privileges local over global or gestalt details. While not a core symptom of autism, individuals with HFA seem to reliably show this bias. Our lab has been studying a sample of children who have overcome their early ASD diagnoses, showing “optimal outcomes” (OO). This study characterizes performance by OO, HFA, and typically developing (TD) adolescents as they describe paintings under cognitive load. Analyses of detail focus in painting descriptions indicated that the HFA group displayed significantly more local focus than both OO and TD groups, while the OO and TD groups did not differ. We discuss implications for the centrality of detail focus to the autism diagnosis. PMID:25563455

Detail and gestalt focus in individuals with optimal outcomes from autism spectrum disorders.

PubMed

Fitch, Allison; Fein, Deborah A; Eigsti, Inge-Marie

2015-06-01

Individuals with high-functioning autism (HFA) have a cognitive style that privileges local over global or gestalt details. While not a core symptom of autism, individuals with HFA seem to reliably show this bias. Our lab has been studying a sample of children who have overcome their early ASD diagnoses, showing "optimal outcomes" (OO). This study characterizes performance by OO, HFA, and typically developing (TD) adolescents as they describe paintings under cognitive load. Analyses of detail focus in painting descriptions indicated that the HFA group displayed significantly more local focus than both OO and TD groups, while the OO and TD groups did not differ. We discuss implications for the centrality of detail focus to the autism diagnosis.

Focused attention, open monitoring and automatic self-transcending: Categories to organize meditations from Vedic, Buddhist and Chinese traditions.

PubMed

Travis, Fred; Shear, Jonathan

2010-12-01

This paper proposes a third meditation-category--automatic self-transcending--to extend the dichotomy of focused attention and open monitoring proposed by Lutz. Automatic self-transcending includes techniques designed to transcend their own activity. This contrasts with focused attention, which keeps attention focused on an object; and open monitoring, which keeps attention involved in the monitoring process. Each category was assigned EEG bands, based on reported brain patterns during mental tasks, and meditations were categorized based on their reported EEG. Focused attention, characterized by beta/gamma activity, included meditations from Tibetan Buddhist, Buddhist, and Chinese traditions. Open monitoring, characterized by theta activity, included meditations from Buddhist, Chinese, and Vedic traditions. Automatic self-transcending, characterized by alpha1 activity, included meditations from Vedic and Chinese traditions. Between categories, the included meditations differed in focus, subject/object relation, and procedures. These findings shed light on the common mistake of averaging meditations together to determine mechanisms or clinical effects. Copyright © 2010 Elsevier Inc. All rights reserved.

CAPILLARY ISOELECTRIC FOCUSING (CIEF) FOR THE CHARACTERIZATION OF HUMIC SUBSTANCES

EPA Science Inventory

Preparative solution isoelectric focusing was used to fractionate 50 mg of a soil fulvic acid (FA); the harvested fractions were characterized with UV-Vis spectroscopy, gel permeation chromatography and capillary zone electrophoresis (CZE) and showed a distribution in the created...

Characterization and microstructure of HPMC/Gly:AgNO3 polymer composites

NASA Astrophysics Data System (ADS)

Ananda, H. T.; Urs, G. Thejas; Somashekar, R.

2018-04-01

This study reports the synthesis and characterization of AgNo3 doped HPMC/Glycerol blend films. The microstructural parameters of these composites were evaluated employing whole powder pattern fitting method (WPPF) and the results obtained are related with other physical properties. AC conductivity results and optical band gap evaluated from UV/Vis studies are focused to establish structure property relations. These composite films are bio-degradable in nature and non-hazardous, this makes them very suitable candidates for applications in appropriate fields.

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis.

PubMed

Lovely, Charles Ben; Fernandes, Yohaan; Eberhart, Johann K

2016-10-01

Fetal Alcohol Spectrum Disorders (FASD) describes a wide array of ethanol-induced developmental defects, including craniofacial dysmorphology and cognitive impairments. It affects ∼1 in 100 children born in the United States each year. Due to the pleiotropic effects of ethanol, animal models have proven critical in characterizing the mechanisms of ethanol teratogenesis. In this review, we focus on the utility of zebrafish in characterizing ethanol-induced developmental defects. A growing number of laboratories have focused on using zebrafish to examine ethanol-induced defects in craniofacial, cardiac, ocular, and neural development, as well as cognitive and behavioral impairments. Growing evidence supports that genetic predisposition plays a role in these ethanol-induced defects, yet little is understood about these gene-ethanol interactions. With a high degree of genetic amenability, zebrafish is at the forefront of identifying and characterizing the gene-ethanol interactions that underlie FASD. Because of the conservation of gene function between zebrafish and humans, these studies will directly translate to studies of candidate genes in human populations and allow for better diagnosis and treatment of FASD.

Ultrasound field measurement using a binary lens

PubMed Central

Clement, G.T.; Nomura, H.; Kamakura, T.

2014-01-01

Field characterization methods using a scattering target in the absence of a point-like receiver have been well described in which scattering is recorded by a relatively large receiver located outside the field of measurement. Unfortunately, such methods are prone to artifacts due to averaging across the receiver surface. To avoid this problem while simultaneously increasing the gain of a received signal, the present study introduces a binary plate lens designed to focus spherically-spreading waves onto a planar region having a nearly-uniform phase proportional to that of the target location. The lens is similar to a zone plate, but modified to produce a biconvex-like behavior, such that it focuses both planar and spherically spreading waves. A measurement device suitable for characterizing narrowband ultrasound signals in air is designed around this lens by coupling it to a target and planar receiver. A prototype device is constructed and used to characterize the field of a highly-focused 400 kHz air transducer along 2 radial lines. Comparison of the measurements with numeric predictions formed from nonlinear acoustic simulation showed good relative pressure correlation, with mean differences of 10% and 12% over center 3dB FWHM drop and 12% and 17% over 6dB. PMID:25643084

Characterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control.

PubMed

Bing, Chenchen; Hong, Yu; Hernandez, Christopher; Rich, Megan; Cheng, Bingbing; Munaweera, Imalka; Szczepanski, Debra; Xi, Yin; Bolding, Mark; Exner, Agata; Chopra, Rajiv

2018-05-22

Focused ultrasound combined with bubble-based agents serves as a non-invasive way to open the blood-brain barrier (BBB). Passive acoustic detection was well studied recently to monitor the acoustic emissions induced by the bubbles under ultrasound energy, but the ability to perform reliable BBB opening with a real-time feedback control algorithm has not been fully evaluated. This study focuses on characterizing the acoustic emissions of different types of bubbles: Optison, Definity, and a custom-made nanobubble. Their performance on reliable BBB opening under real-time feedback control based on acoustic detection was evaluated both in-vitro and in-vivo. The experiments were conducted using a 0.5 MHz focused ultrasound transducer with in-vivo focal pressure ranges from 0.1-0.7 MPa. Successful feedback control was achieved with all three agents when combining with infusion injection. Localized opening was confirmed with Evans blue dye leakage. Microscopic images were acquired to review the opening effects. Under similar total gas volume, nanobubble showed a more reliable opening effect compared to Optison and Definity (p < 0.05). The conclusions obtained from this study confirm the possibilities of performing stable opening using a feedback control algorithm combined with infusion injection. It also opens another potential research area of BBB opening using sub-micron bubbles.

The spectroscopic characterization of newly developed emissive materials and the effects of environment on their photophysical properties

NASA Astrophysics Data System (ADS)

McNamara, Louis Edward, III

The development of new materials capable of efficient charge transfer and energy storage has become increasingly important in many areas of modern chemical research. This is especially true for the development of emissive optoelectronic devices and in the field of solar to electric energy conversion. The characterization of the photophysical properties of new molecular systems for these applications has become critical in the design and development of these materials. Many molecular building blocks have been developed and understanding the properties of these molecules at a fundamental level is essential for their successful implementation and future engineering. This dissertation focuses on the characterization of some of these newly-developed molecular systems. The spectroscopic studies focus on the characterization of newly-developed molecules based on perylene and indolizine derivatives for solar to electric energy conversion, thienopyrazine derivatives for near infrared (NIR) emissive applications, an SCS pincer complex for blue emissive materials and a fluorescent probe for medical applications. The effects of noncovalent interactions are also investigated on these systems and a benchmark biological molecule trimethylamine N-oxide (TMAO).

Chemicals under the Toxic Substances Control Act (TSCA)

EPA Pesticide Factsheets

This web area will allow stakeholders to search and view centralized chemical info from various systems. This page will focus on TSCA chemical data such as health and safety studies, risk assessments and hazard characterizations.

The Focusing Optics X-ray Solar Imager (FOXSI): Instrument and First Flight

NASA Astrophysics Data System (ADS)

Glesener, Lindsay; Christe, S.; Ishikawa, S.; Ramsey, B.; Takahashi, T.; Saito, S.; Lin, R. P.; Krucker, S.; FOXSI Team

2013-04-01

Understanding electron acceleration in solar flares requires hard X-ray studies with greater sensitivity and dynamic range than are available with current solar hard X-ray observers (i.e. the RHESSI spacecraft). Both these capabilities can be advanced by the use of direct focusing optics instead of the indirect Fourier methods of current and previous generations. The Focusing Optics X-ray Solar Imager (FOXSI) sounding rocket payload demonstrates the feasibility and usefulness of hard X-ray focusing optics for solar observation. FOXSI flew for the first time on 2012 November 2, producing images and spectra of a microflare and performing a search for nonthermal X-rays from the quiet Sun. Such measurements are important for characterizing the impact of small "nanoflares" on the solar coronal heating problem. A spaceborne solar observer featuring similar optics could make detailed observations of hard X-rays from flare-accelerated electrons, identifying and characterizing particle acceleration sites and mapping out paths of energetic electrons as they leave these sites and propagate throughout the solar corona. Solar observations from NuSTAR are also expected to be an important step in this direction.

Characterization of the canine urinary proteome.

PubMed

Brandt, Laura E; Ehrhart, E J; Scherman, Hataichanok; Olver, Christine S; Bohn, Andrea A; Prenni, Jessica E

2014-06-01

Urine is an attractive biofluid for biomarker discovery as it is easy and minimally invasive to obtain. While numerous studies have focused on the characterization of human urine, much less research has focused on canine urine. The objectives of this study were to characterize the universal canine urinary proteome (both soluble and exosomal), to determine the overlap between the canine proteome and a representative human urinary proteome study, to generate a resource for future canine studies, and to determine the suitability of the dog as a large animal model for human diseases. The soluble and exosomal fractions of normal canine urine were characterized using liquid chromatography tandem mass spectrometry (LC-MS/MS). Biological Networks Gene Ontology (BiNGO) software was utilized to assign the canine urinary proteome to respective Gene Ontology categories, such as Cellular Component, Molecular Function, and Biological Process. Over 500 proteins were confidently identified in normal canine urine. Gene Ontology analysis revealed that exosomal proteins were largely derived from an intracellular location, while soluble proteins included both extracellular and membrane proteins. Exosome proteins were assigned to metabolic processes and localization, while soluble proteins were primarily annotated to specific localization processes. Several proteins identified in normal canine urine have previously been identified in human urine where these proteins are related to various extrarenal and renal diseases. The results of this study illustrate the potential of the dog as an animal model for human disease states and provide the framework for future studies of canine renal diseases. © 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.

Workload Characterization of CFD Applications Using Partial Differential Equation Solvers

NASA Technical Reports Server (NTRS)

Waheed, Abdul; Yan, Jerry; Saini, Subhash (Technical Monitor)

1998-01-01

Workload characterization is used for modeling and evaluating of computing systems at different levels of detail. We present workload characterization for a class of Computational Fluid Dynamics (CFD) applications that solve Partial Differential Equations (PDEs). This workload characterization focuses on three high performance computing platforms: SGI Origin2000, EBM SP-2, a cluster of Intel Pentium Pro bases PCs. We execute extensive measurement-based experiments on these platforms to gather statistics of system resource usage, which results in workload characterization. Our workload characterization approach yields a coarse-grain resource utilization behavior that is being applied for performance modeling and evaluation of distributed high performance metacomputing systems. In addition, this study enhances our understanding of interactions between PDE solver workloads and high performance computing platforms and is useful for tuning these applications.

Identifying the role of initial wave parameters on tsunami focusing

NASA Astrophysics Data System (ADS)

Aydın, Baran

2018-04-01

Unexpected local tsunami amplification, which is referred to as tsunami focusing, is attributed to two different mechanisms: bathymetric features of the ocean bottom such as underwater ridges and dipolar shape of the initial wave itself. In this study, we characterize the latter; that is, we explore how amplitude and location of the focusing point vary with certain geometric parameters of the initial wave such as its steepness and crest length. Our results reveal two important features of tsunami focusing: for mild waves maximum wave amplitude increases significantly with transverse length of wave crest, while location of the focusing point is almost invariant. For steep waves, on the other hand, increasing crest length dislocates focusing point significantly, while it causes a rather small increase in wave maximum.

Vegetation, Soil, and Flooding Relationships in a Blackwater Floodplain Forest

Treesearch

Sammy L. King; David Gartner; Mark H. Eisenbies

2003-01-01

Hydroperiod is considered the primary determinant of plant species distribution in temperate floodplain forests, but most studies have focused on alluvial (sediment-laden) river systems. Few studies have evaluated plant community relationships in blackwater river systems of the South Atlantic Coastal Plain of North America. In this study. we characterized the soils....

State-of-the-art study of resource characterization and planning for underground coal mining. Final technical report as of June 30, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walton, D.; Ingham, W.; Kauffman, P.

With the rapid developments taking place in coal mining technology and due to high investment costs, optimization of the structure of underground coal mines is crucial to the success of the mining project. The structure of a mine, once it is developed, cannot be readily changed and has a decisive influence on the productivity, safety, economics, and production capacity of the mine. The Department of Energy desires to ensure that the resource characterization and planning activity for underground coal mining will focus on those areas that offer the most promise of being advanced. Thus, this project was undertaken by Managementmore » Engineers Incorporated to determine the status in all aspects of the resource characterization and planning activities for underground coal mining as presently performed in the industry. The study team conducted a comprehensive computerized literature search and reviewed the results. From this a selection of the particularly relevant sources were annotated and a reference list was prepared, catalogued by resource characterization and mine planning activity. From this data, and discussions with industry representatives, academia, and research groups, private and federal, an assessment and evaluation was made of the state-of-the-art of each element in the resource characterization and mine planning process. The results of this analysis lead to the identifcation of areas requiring research and, specifically, those areas where DOE research efforts may be focused.« less

Acute Blood Loss During Burn and Soft Tissue Excisions: An Observational Study of Blood Product Resuscitation Practices and Focused Review

DTIC Science & Technology

2015-06-24

centers have shifted to a damage-control resuscitation approach, focused on providing oxygen - carrying capacity while simultaneously mitigating...develop treatments for this widely recognized problem have yet to yield effective solutions. In both the ci- vilian and military settings, most deaths...characterizing the effects of significant intraoperative bleeding on coagulation may be an alternative source of data to guide ORIGINAL ARTICLE J

Peace Studies, the Gulf War, and Peace.

ERIC Educational Resources Information Center

Stephenson, Carolyn M.

1991-01-01

Peace studies, as an academic discipline, dates back to the 1950s, when the field was characterized primarily by research. The 1970s brought a focus on undergraduate education. In the 1980s, a third wave brought the field into a prominence that allows it to challenge the Gulf War. (SLD)

Alternative Environments for Basic Skills Development.

ERIC Educational Resources Information Center

Crowe, Michael R.; And Others

This study focused on the identification and description of environmental characteristics and their relationship to basic skills exposure. The objectives of the study were to identify the major factors that characterize environments in which learning is intended to occur, and to delineate patterns of co-exposure to basic skills and environmental…

Assessment of Sediment Contamination, Toxicity and Benthic Community Composition in Ukrainian Part of Danube Delta

EPA Science Inventory

This study focused on identifying impaired and unimpaired areas (i.e., reference) within the Ukrainian portion of the Danube Delta using modern environmental diagnostic approaches and tools. To characterize the state of the areas under study, a triad approach was used including c...

Teaching for Historical Literacy

ERIC Educational Resources Information Center

Goudvis, Anne; Harvey, Stephanie

2012-01-01

Just as people focused on education in the United States call for more content-rich curriculums, elementary schools in many areas have squeezed history and social studies out of their school day. When social studies is taught, it's often characterized by overreliance on a textbook and "covering" isolated facts; extended, engaged reading…

Evolution of diffusion and dissemination theory.

PubMed

Dearing, James W

2008-01-01

The article provides a review and considers how the diffusion of innovations Research paradigm has changed, and offers suggestions for the further development of this theory of social change. Main emphases of diffusion Research studies are compared over time, with special attention to applications of diffusion theory-based concepts as types of dissemination science. A considerable degree of paradigmatic evolution is observed. The classical diffusion model focused on adopter innovativeness, individuals as the locus of decision, communication channels, and adoption as the primary outcome measures in post hoc observational study designs. The diffusion systems in question were centralized, with fidelity of implementation often assumed. Current dissemination Research and practice is better characterized by tests of interventions that operationalize one or more diffusion theory-based concepts and concepts from other change approaches, involve complex organizations as the units of adoption, and focus on implementation issues. Foment characterizes dissemination and implementation Research, Reflecting both its interdisciplinary Roots and the imperative of spreading evidence-based innovations as a basis for a new paradigm of translational studies of dissemination science.

Inter-comparison of multiple statistically downscaled climate datasets for the Pacific Northwest, USA

PubMed Central

Jiang, Yueyang; Kim, John B.; Still, Christopher J.; Kerns, Becky K.; Kline, Jeffrey D.; Cunningham, Patrick G.

2018-01-01

Statistically downscaled climate data have been widely used to explore possible impacts of climate change in various fields of study. Although many studies have focused on characterizing differences in the downscaling methods, few studies have evaluated actual downscaled datasets being distributed publicly. Spatially focusing on the Pacific Northwest, we compare five statistically downscaled climate datasets distributed publicly in the US: ClimateNA, NASA NEX-DCP30, MACAv2-METDATA, MACAv2-LIVNEH and WorldClim. We compare the downscaled projections of climate change, and the associated observational data used as training data for downscaling. We map and quantify the variability among the datasets and characterize the spatio-temporal patterns of agreement and disagreement among the datasets. Pair-wise comparisons of datasets identify the coast and high-elevation areas as areas of disagreement for temperature. For precipitation, high-elevation areas, rainshadows and the dry, eastern portion of the study area have high dissimilarity among the datasets. By spatially aggregating the variability measures into watersheds, we develop guidance for selecting datasets within the Pacific Northwest climate change impact studies. PMID:29461513

Inter-comparison of multiple statistically downscaled climate datasets for the Pacific Northwest, USA.

PubMed

Jiang, Yueyang; Kim, John B; Still, Christopher J; Kerns, Becky K; Kline, Jeffrey D; Cunningham, Patrick G

2018-02-20

Statistically downscaled climate data have been widely used to explore possible impacts of climate change in various fields of study. Although many studies have focused on characterizing differences in the downscaling methods, few studies have evaluated actual downscaled datasets being distributed publicly. Spatially focusing on the Pacific Northwest, we compare five statistically downscaled climate datasets distributed publicly in the US: ClimateNA, NASA NEX-DCP30, MACAv2-METDATA, MACAv2-LIVNEH and WorldClim. We compare the downscaled projections of climate change, and the associated observational data used as training data for downscaling. We map and quantify the variability among the datasets and characterize the spatio-temporal patterns of agreement and disagreement among the datasets. Pair-wise comparisons of datasets identify the coast and high-elevation areas as areas of disagreement for temperature. For precipitation, high-elevation areas, rainshadows and the dry, eastern portion of the study area have high dissimilarity among the datasets. By spatially aggregating the variability measures into watersheds, we develop guidance for selecting datasets within the Pacific Northwest climate change impact studies.

Energy Supply- Production of Fuel from Agricultural and Animal Waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gabriel Miller

2009-03-25

The Society for Energy and Environmental Research (SEER) was funded in March 2004 by the Department of Energy, under grant DE-FG-36-04GO14268, to produce a study, and oversee construction and implementation, for the thermo-chemical production of fuel from agricultural and animal waste. The grant focuses on the Changing World Technologies (CWT) of West Hempstead, NY, thermal conversion process (TCP), which converts animal residues and industrial food processing biproducts into fuels, and as an additional product, fertilizers. A commercial plant was designed and built by CWT, partially using grant funds, in Carthage, Missouri, to process animal residues from a nearby turkey processingmore » plant. The DOE sponsored program consisted of four tasks. These were: Task 1 Optimization of the CWT Plant in Carthage - This task focused on advancing and optimizing the process plant operated by CWT that converts organic waste to fuel and energy. Task 2 Characterize and Validate Fuels Produced by CWT - This task focused on testing of bio-derived hydrocarbon fuels from the Carthage plant in power generating equipment to determine the regulatory compliance of emissions and overall performance of the fuel. Task 3 Characterize Mixed Waste Streams - This task focused on studies performed at Princeton University to better characterize mixed waste incoming streams from animal and vegetable residues. Task 4 Fundamental Research in Waste Processing Technologies - This task focused on studies performed at the Massachusetts Institute of Technology (MIT) on the chemical reformation reaction of agricultural biomass compounds in a hydrothermal medium. Many of the challenges to optimize, improve and perfect the technology, equipment and processes in order to provide an economically viable means of creating sustainable energy were identified in the DOE Stage Gate Review, whose summary report was issued on July 30, 2004. This summary report appears herein as Appendix 1, and the findings of the report formed the basis for much of the subsequent work under the grant. An explanation of the process is presented as well as the completed work on the four tasks.« less

Spray Droplet Characterization from a Single Nozzle by High Speed Image Analysis Using an In-Focus Droplet Criterion

PubMed Central

Vulgarakis Minov, Sofija; Cointault, Frédéric; Vangeyte, Jürgen; Pieters, Jan G; Nuyttens, David

2016-01-01

Accurate spray characterization helps to better understand the pesticide spray application process. The goal of this research was to present the proof of principle of a droplet size and velocity measuring technique for different types of hydraulic spray nozzles using a high speed backlight image acquisition and analysis system. As only part of the drops of an agricultural spray can be in focus at any given moment, an in-focus criterion based on the gray level gradient was proposed to decide whether a given droplet is in focus or not. In a first experiment, differently sized droplets were generated with a piezoelectric generator and studied to establish the relationship between size and in-focus characteristics. In a second experiment, it was demonstrated that droplet sizes and velocities from a real sprayer could be measured reliably in a non-intrusive way using the newly developed image acquisition set-up and image processing. Measured droplet sizes ranged from 24 μm to 543 μm, depending on the nozzle type and size. Droplet velocities ranged from around 0.5 m/s to 12 m/s. The droplet size and velocity results were compared and related well with the results obtained with a Phase Doppler Particle Analyzer (PDPA). PMID:26861338

Spray Droplet Characterization from a Single Nozzle by High Speed Image Analysis Using an In-Focus Droplet Criterion.

PubMed

Minov, Sofija Vulgarakis; Cointault, Frédéric; Vangeyte, Jürgen; Pieters, Jan G; Nuyttens, David

2016-02-06

Accurate spray characterization helps to better understand the pesticide spray application process. The goal of this research was to present the proof of principle of a droplet size and velocity measuring technique for different types of hydraulic spray nozzles using a high speed backlight image acquisition and analysis system. As only part of the drops of an agricultural spray can be in focus at any given moment, an in-focus criterion based on the gray level gradient was proposed to decide whether a given droplet is in focus or not. In a first experiment, differently sized droplets were generated with a piezoelectric generator and studied to establish the relationship between size and in-focus characteristics. In a second experiment, it was demonstrated that droplet sizes and velocities from a real sprayer could be measured reliably in a non-intrusive way using the newly developed image acquisition set-up and image processing. Measured droplet sizes ranged from 24 μm to 543 μm, depending on the nozzle type and size. Droplet velocities ranged from around 0.5 m/s to 12 m/s. The droplet size and velocity results were compared and related well with the results obtained with a Phase Doppler Particle Analyzer (PDPA).

The M 4 Core Project with HST - V. Characterizing the PSFs of WFC3/UVIS by focus★

NASA Astrophysics Data System (ADS)

Anderson, J.; Bedin, L. R.

2017-09-01

As part of the astrometric Hubble Space Telescope (HST) large program GO-12911, we conduct an in-depth study to characterize the point spread function (PSF) of the Uv-VISual channel of the Wide Field Camera 3 (WFC3), as a necessary step to achieve the astrometric goals of the program. We extracted a PSF from each of the 589 deep exposures taken through the F467M filter over the course of a year and find that the vast majority of the PSFs lie along a 1-D locus that stretches continuously from one side of focus, through optimal focus, to the other side of focus. We constructed a focus-diverse set of PSFs and find that with only five medium-bright stars in an exposure it is possible to pin down the focus level of that exposure. We show that the focus-optimized PSF does a considerably better job fitting stars than the average 'library' PSF, especially when the PSF is out of focus. The fluxes and positions are significantly improved over the 'library' PSF treatment. These results are beneficial for a much broader range of scientific applications than simply the program at hand, but the immediate use of these PSFs will enable us to search for astrometric wobble in the bright stars in the core of the globular cluster M 4, which would indicate a dark, high-mass companion, such as a white dwarf, neutron star or black hole.

Growing gratitude in undergraduate nursing students: Applying findings from social and psychological domains to nursing education.

PubMed

Fournier, Ann; Sheehan, Caryn

2015-12-01

Millennial students are often characterized as technology focused multitaskers, yet young nursing students are expected to focus on and thoughtfully engage with the person at the center of their caring efforts. Developing gratitude practices requires quiet contemplation and focus. Cultivating an attitude of gratitude in millennial nursing students may be one avenue to address concerns surrounding the provision of relationship based person-centered care by young nurses. In other disciplines, gratitude work has been studied extensively and is associated with several positive outcomes. Assignments included in most nursing programs can easily be modified to include a gratitude focus. Examples of gratitude assignments and the student reflection of these assignments are included here as a call for nurse educators to further study this concept. Copyright © 2015 Elsevier Ltd. All rights reserved.

School-Nongovernmental Organization Engagement as an Entrepreneurial Venture: A Case Study of Sunlight's Engagement with Israeli Schools

ERIC Educational Resources Information Center

Yemini, Miri; Sagie, Netta

2015-01-01

Purpose: This study examines the objectives, nature, and perceived outcomes of school-nongovernmental organization (school-NGO) engagements in the Israeli education system, focusing on a single case study of a school-NGO interaction. We aim to characterize the conflicting motivations of each stakeholder involved in the creation and formulation of…

Characterization of Copper Corrosion Products in Drinking Water by Combining Electrochemical and Surface Analyses

EPA Science Inventory

This study focuses on the application of electrochemical approaches to drinking water copper corrosion problems. Applying electrochemical approaches combined with copper solubility measurements, and solid surface analysis approaches were discussed. Tafel extrapolation and Electro...

Characterization of Copper Corrosion Products Formed in Drinking Water by Combining Electrochemical and Surface Analyses

EPA Science Inventory

This study focuses on the application of electrochemical approaches to drinking water copper corrosion problems. Applying electrochemical approaches combined with copper solubility measurements, and solid surface analysis approaches were discussed. Tafel extrapolation and Electro...

Purification and Characterization of Taq Polymerase: A 9-Week Biochemistry Laboratory Project for Undergraduate Students

ERIC Educational Resources Information Center

Bellin, Robert M.; Bruno, Mary K.; Farrow, Melissa A.

2010-01-01

We have developed a 9-week undergraduate laboratory series focused on the purification and characterization of "Thermus aquaticus" DNA polymerase (Taq). Our aim was to provide undergraduate biochemistry students with a full-semester continuing project simulating a research-like experience, while having each week's procedure focus on a single…

X-ray tomography characterization of density gradient aerogel in laser targets

NASA Astrophysics Data System (ADS)

Borisenko, L.; Orekhov, A.; Musgrave, C.; Nazarov, W.; Merkuliev, Yu; Borisenko, N.

2016-04-01

The low-density solid laser target characterization studies begun with the SkyScan 1074 computer microtomograph (CMT) [1, 2] are now continued with higher resolution of SkyScan 1174. The research is particularly focused on the possibility to obtain, control and measure precisely the gradient density polymers for laser target production. Repeatability of the samples and possibility to obtain stable gradients are analysed. The measurements were performed on the mm-scale divinyl benzene (DVB) rods.

Contributing to Tumor Molecular Characterization Projects with a Global Impact | Office of Cancer Genomics

Cancer.gov

My name is Nicholas Griner and I am the Scientific Program Manager for the Cancer Genome Characterization Initiative (CGCI) in the Office of Cancer Genomics (OCG). Until recently, I spent most of my scientific career working in a cancer research laboratory. In my postdoctoral training, my research focused on identifying novel pathways that contribute to both prostate and breast cancers and studying proteins within these pathways that may be targeted with cancer drugs.

Experimental characterization of active plasma lensing for electron beams

NASA Astrophysics Data System (ADS)

Pompili, R.; Anania, M. P.; Bellaveglia, M.; Biagioni, A.; Bini, S.; Bisesto, F.; Brentegani, E.; Castorina, G.; Chiadroni, E.; Cianchi, A.; Croia, M.; Di Giovenale, D.; Ferrario, M.; Filippi, F.; Giribono, A.; Lollo, V.; Marocchino, A.; Marongiu, M.; Mostacci, A.; Di Pirro, G.; Romeo, S.; Rossi, A. R.; Scifo, J.; Shpakov, V.; Vaccarezza, C.; Villa, F.; Zigler, A.

2017-03-01

The active plasma lens represents a compact and affordable tool with radially symmetric focusing and field gradients up to several kT/m. In order to be used as a focusing device, its effects on the particle beam distribution must be well characterized. Here, we present the experimental results obtained by focusing an high-brightness electron beam by means of a 3 cm-long discharge-capillary pre-filled with Hydrogen gas. We achieved minimum spot sizes of 24 μ m (rms) showing that, during plasma lensing, the beam emittance increases due to nonlinearities in the focusing field. The results have been cross-checked with numerical simulations, showing an excellent agreement.

Learning to Eat Politely at the Chinese Homestay Dinner Table: Two Contrasting Case Studies

ERIC Educational Resources Information Center

Lee, Sheng-Hsun; Wu, Qian; Di, Chunyuan; Kinginger, Celeste

2017-01-01

While study abroad homestays are often credited with providing opportunities for language and cultural learning, at times they can be characterized by communicative, cross-cultural, or interpersonal discord. In documenting these conflicts and their consequences, research to date has relied largely on students' self-reports, often focusing on their…

Temporal Phenomena in the Korean Conjunctive Constructions

ERIC Educational Resources Information Center

Kim, Dongmin

2015-01-01

The goal of this study is to characterize the temporal phenomena in the Korean conjunctive constructions. These constructions consist of three components: a verbal stem, a clause medial temporal suffix, and a clause terminal suffix. This study focuses on both the temporality of the terminal connective suffixes and the grammatical meanings of the…

Connected Lighting System Interoperability Study Part 1: Application Programming Interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gaidon, Clement; Poplawski, Michael

First in a series of studies that focuses on interoperability as realized by the use of Application Programming Interfaces (APIs), explores the diversity of such interfaces in several connected lighting systems; characterizes the extent of interoperability that they provide; and illustrates challenges, limitations, and tradeoffs that were encountered during this exploration.

CHARACTERIZATION OF THE FUGITIVE MERCURY EMISSIONS AT A CHLOR-ALKALI PLANT. OVERALL STUDY DESIGN

EPA Science Inventory

The paper discusses a detailed emissions measurement campaign that was conducted over a 9-day period within a mercury (Hg) cell chlor-alkali plant in the southeastern United States (U.S.). The principal focus of this study was to measure fugitive (non-ducted) airborne Hg emission...

Adolescent Risk Behavior and Experiences with Flow

ERIC Educational Resources Information Center

Bettencourt, Kristen

2017-01-01

This study explored the relationship between adolescent risk behavior and flow, a state of optimal experience characterized by a spontaneous and fluid, yet deeply focused state of awareness (Csikszentmihalyi, 1996). The purpose of the study was to better understand adolescent risk taking, as well as how it may interact with experiences of flow.…

Spectral and Geological Characterization of Beach Components in Northern Puerto Rico

NASA Astrophysics Data System (ADS)

Caraballo Álvarez, I. O.; Torres-Perez, J. L.; Barreto, M.

2015-12-01

Understanding how changes in beach components may reflect beach processes is essential since variations along beach profiles can shed light on river and ocean processes influencing beach sedimentation and beachrock formation. It is likely these influences are related to beach proximity within the Río Grande de Manatí river mouth. Therefore, this study focuses on characterizing beach components at two sites in Manatí, Puerto Rico. Playa Machuca and Playa Tombolo, which are separated by eolianites, differ greatly in sediment size, mineralogy, and beachrock morphology. Several approaches were taken to geologically and spectrally characterize main beach components at each site. These approaches included field and microscopic laboratory identification, granulometry, and a comparison between remote sensing reflectance (Rrs) obtained with a field spectroradiometer and pre-existing spectral library signatures. Preliminary results indicate a positive correlation between each method. This study may help explore the possibility of using only Rrs to characterize beach and shallow submarine components for detailed image analysis and management of coastal features.This study focuses on characterizing beach components at two sites in Manatí, Puerto Rico. Playa Machuca and Playa Tombolo, two beaches that are separated by eolianites, differ greatly in sediment size and mineralogy, as well as in beachrock morphology. Understanding how changes in beach components may reflect beach processes is essential, since it is likely that differences are mostly related to each beaches' proximity to the Río Grande de Manatí river mouth. Hence, changes in components along beach profiles can shed light on the river's and the ocean's influence on beach sedimentation and beachrock formation. Several approaches were taken to properly geologically and spectrally characterize the main beach components at each site. These approaches included field and microscopic laboratory identification, granulometry, and a comparison between remote sensing reflectance (Rrs) obtained with a field spectroradiometer and the ENVI spectral library. Preliminary results show a positive correlation between each method. This study may help explore the possibility of using only Rrs to characterize beach and shallow submarine components for detailed image analysis and management of coastal features.

Surface topography characterization of brass alloys: lead brass (CuZn39Pb3) and lead free brass (CuZn21Si3P)

NASA Astrophysics Data System (ADS)

Reddy, Vijeth V.; Vedantha Krishna, Amogh; Schultheiss, Fredrik; Rosén, B.-G.

2017-06-01

Manufactured surfaces usually consist of topographical features which include both those put forth by the manufacturing process, and micro-features caused by disturbances during this process. Surface characterization basically involves study of these features which influence the functionality of the surface. This article focuses on characterization of the surface topography of machined lead brass and lead free brass. The adverse effect of lead on human health and the environment has led the manufacturing sector to focus on sustainable manufacturing of lead free brass, as well as how to maintain control of the surface integrity when substituting the lead content in the brass with silicon. The investigation includes defined areal surface parameters measured on the turned samples of lead- and lead free brass using an optical coherence scanning interferometer, CSI. This paper deals with the study of surface topography of turned samples of lead- and lead free brass. It is important to study the topographical characteristics of the brass samples which are the intermediate link between the manufacturing process variables and the functional behaviour of the surface. To numerically evaluate the sample’s surface topography and to validate the measurements for a significant study, a general statistical methodology is implemented. The results indicate higher surface roughness in turned samples of lead brass compared to lead free brass.

Sulfates on Mars as Markers of Aqueous Processes: An Integrated Multidisciplinary Study of Minerals, Mars Analog sites and Recent Mission Data

NASA Technical Reports Server (NTRS)

Bishop, J. L.; Lane, M. D.; Dyar, M. D.; Brown, A. J.; Parente, M.

2006-01-01

Our analyses of sulfate minerals, analog sites, and Martian spectra and spectral images is focused on characterization of the Martian surface and in particular identification of aqueous processes there.

Recycled Asphalt Pavement and Crushed Concrete Backfill: State-of-the-Art Review and Material Characterization

DOT National Transportation Integrated Search

2001-10-01

This report describes research results from the first year of a three-year study focused on the use of recycled asphalt pavement (RAP) and crushed concrete (CC) as backfill for mechanically stabilized earth (MSE) walls.

Evaluation of land use regression models in Detroit, Michigan

EPA Science Inventory

Introduction: Land use regression (LUR) models have emerged as a cost-effective tool for characterizing exposure in epidemiologic health studies. However, little critical attention has been focused on validation of these models as a step toward temporal and spatial extension of ...

Characterization of bridge foundations workshop report.

DOT National Transportation Integrated Search

2013-11-01

"In 2013, the Federal Highway Administration proposed a new research program for the characterization of bridge foundations. To narrow the focus and develop a research roadmap for the program, a workshop on Characterization of Bridge Foundations...

Characterization of bridge foundations workshop report.

DOT National Transportation Integrated Search

2013-11-01

In 2013, the Federal Highway Administration proposed a new research program for the characterization of bridge : foundations. To narrow the focus and develop a research roadmap for the program, a workshop on : Characterization of Bridge Foundation...

Combined application of imaging techniques for the characterization and authentication of ancient weapons

NASA Astrophysics Data System (ADS)

Salvemini, Filomena; Grazzi, Francesco; Kardjilov, Nikolay; Wieder, Frank; Manke, Ingo; Edge, David; Williams, Alan; Zoppi, Marco

2017-05-01

Non-invasive experimental methods play an important role in the field of cultural heritage. Benefiting from the technical progress in recent years, neutron imaging has been demonstrated to complement effectively studies based on surface analysis, allowing for a non-invasive characterization of the whole three-dimensional volume. This study focuses on a kris and a kanjar, two weapons from ancient Asia, to show the potential of the combined use of X-ray and neutron imaging techniques for the characterisation of the manufacturing methods and the authentication of objects of cultural and historical interest.

AVTA federal fleet PEV readiness data logging and characterization study for the National Park Service: Grand Canyon National Park

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Stephen; Francfort, Jim; Nienhueser, Ian

This report focuses on the Grand Canyon National Park (GCNP) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively PEVs) can fulfill the mission requirements.

Phosphates based pigments for new anti-corrosion application: Synthesis and characterization

NASA Astrophysics Data System (ADS)

Tbib, B.; Eddya, M.; El-Hami, K.

2018-02-01

Our study focused on pyrophosphates SrZn1-xMxP2O7 using four series by substituting M with manganese (Mn), cobalt (Co), nickel (Ni), and copper (Cu). They were prepared by reaction in the solid state at 1000 °C for 24 hours and then characterized by X-ray diffraction, which showed that the obtained products are pure. The characterization by UV-visible spectroscopy was used to explain the color of the obtained materials and the optical properties showing the optical energy gap and disorder of these materials. Potential application could be done using the new anti-corrosion pigments based on phosphates.

Microfluidic inertial focusing fundamentals, limitations and applications for biomedical sample processing

NASA Astrophysics Data System (ADS)

Reece, Amy E.

The microfabrication of microfluidic control systems and advances in molecular amplification tools has enabled the miniaturization of single cell analytical platforms for the efficient, highly selective enumeration and molecular characterization of rare and diseased cells from clinical samples. In many cases, the high-throughput nature of microfluidic inertial focusing has enabled the popularization of this new class of Lab-on-a-Chip devices that exhibit numerous advantages over conventional methods as prognostic and diagnostic tools. Inertial focusing is the passive, sheathless alignment of particles and cells to precise spatiotemporal equilibrium positions that arise from a force balance between opposing inertial lift forces and hydrodynamic repulsions. The applicability of inertial focusing to a spectrum of filtration, separation and encapsulation challenges places heavy emphasis upon the accurate description of the hydrodynamic forces responsible for predictable inertial focusing behavior. These inertial focusing fundamentals, limitations and their applications are studied extensively throughout this work.

Characterization of wetland, forest, and agricultural ecosystems in Belize with airborne radar (AIRSAR)

NASA Technical Reports Server (NTRS)

Pope, Kevin O.; Rey-Benayas, Jose Maria; Paris, Jack F.

1992-01-01

The Shuttle Imaging Radar-C/X-SAR (Synthetic Aperture Radar) Experiment includes the study of wetland dynamics in the seasonal tropics. In preparation for these wetland studies, airborne P, L, and C band radar (AIRSAR) data of Belize, Guatemala, and Mexico acquired by NASA and JPL in March 1990 were analyzed. The first phase of our study focuses on AIRSAR data from the Gallon Jug test site in northwestern Belize, for which ground data were also collected during the three days prior to the overflight. One of the main objectives of the Gallon Jug study is to develop a method for characterizing wetland vegetation types and their flooding status with multifrequency polarimetric radar data.

AN INTERDISCIPLINARY APPROACH TO RIPARIAN MEADOW CHARACTERIZATION AND PRIORITIZATION, CENTRAL GREAT BASIN

EPA Science Inventory

The Great Basin Ecosystem Management Research group has described the hydrological, geophysical, and geomorphic conditions that lead to the formation and maintenance of riparian meadows of central Nevada. Previous work on these systems has focused on understanding a few study mea...

Characterizing Resilience and Growth Among Soldiers: A Trajectory Study

DTIC Science & Technology

2012-04-01

casualties of cruel environments or bad genetics . Positive psychology challenges the assumptions of the disease model. It calls for as much focus on...by psychologists, under several different rubrics : dispositional optimism by Carver and Scheier (1981), hope by Snyder (2000), and explanatory style

Giftedness and Aesthetics: Perspectives of Expert Mathematicians and Mathematically Gifted Students

ERIC Educational Resources Information Center

Tjoe, Hartono

2015-01-01

Giftedness in mathematics has been characterized by exceptional attributes including strong mathematical memory, formalizing perception, generalization, curtailment, flexibility, and elegance. Focusing on the last attribute, this study examined the following: (a) the criteria which expert mathematicians and mathematically gifted students fleshed…

INVESTIGATION OF HYDROLOEGROLOGIC MAPPING TO DELINEATE PROTECTION ZONES AROUND SPRINGS: REPORT OF TWO CASE STUDIES

EPA Science Inventory

Methods commonly used to delineate protection zones for water-supply wells are often not directly applicable for springs. This investigation focuses on characterization of the hydrogeologic setting using hydrogeologic mapping methods to identify geologic and hydrologic features ...

Characterizing the Anomalous Cognition-Emotion Interactions in Externalizing

PubMed Central

Baskin-Sommers, Arielle R.; Curtin, John J.; Larson, Christine L.; Stout, Daniel; Kiehl, Kent A.; Newman, Joseph P.

2012-01-01

Externalizing traits are characterized by exaggerated emotional (e.g., frustration, anger) and behavioral (e.g., drug seeking, reactive aggression) reactions to motivationally-significant stimuli. Explanations for this exaggerated reactivity emphasize attention, executive function, and affective processes, but the associations among these processes is rarely investigated. To examine these interactions, we measure fear potentiated startle (FPS; Experiment 1) and neural activation (Experiment 2) in an instructed fear paradigm that manipulates attentional focus, demands on executive functioning, and emotion. In both studies, exaggerated emotional reactivity associated with externalizing was specific to conditions that focused attention on threat information and placed minimal demands on executive functioning. Results suggest that a crucial cognition-emotion interaction affecting externalizing is the over-prioritization and over-allocation of attention to motivationally-significant information, which in turn, may impair executive and affective regulation. PMID:22579718

Examination of time-reversal acoustics in shallow water and applications to noncoherent underwater communications.

PubMed

Smith, Kevin B; Abrantes, Antonio A M; Larraza, Andres

2003-06-01

The shallow water acoustic communication channel is characterized by strong signal degradation caused by multipath propagation and high spatial and temporal variability of the channel conditions. At the receiver, multipath propagation causes intersymbol interference and is considered the most important of the channel distortions. This paper examines the application of time-reversal acoustic (TRA) arrays, i.e., phase-conjugated arrays (PCAs), that generate a spatio-temporal focus of acoustic energy at the receiver location, eliminating distortions introduced by channel propagation. This technique is self-adaptive and automatically compensates for environmental effects and array imperfections without the need to explicitly characterize the environment. An attempt is made to characterize the influences of a PCA design on its focusing properties with particular attention given to applications in noncoherent underwater acoustic communication systems. Due to the PCA spatial diversity focusing properties, PC arrays may have an important role in an acoustic local area network. Each array is able to simultaneously transmit different messages that will focus only at the destination receiver node.

An Overview of the Launch Vehicle Blast Environments Development Efforts

NASA Technical Reports Server (NTRS)

Richardson, Erin; Bangham, Mike; Blackwood, James; Skinner, Troy; Hays, Michael; Jackson, Austin; Richman, Ben

2014-01-01

NASA has been funding an ongoing development program to characterize the explosive environments produced during a catastrophic launch vehicle accident. These studies and small-scale tests are focused on the near field environments that threaten the crew. The results indicate that these environments are unlikely to result in immediate destruction of the crew modules. The effort began as an independent assessment by NASA safety organizations, followed by the Ares program and NASA Engineering and Safety Center and now as a Space Launch Systems (SLS) focused effort. The development effort is using the test and accident data available from public or NASA sources as well as focused scaled tests that are examining the fundamental aspects of uncontained explosions of Hydrogen and air and Hydrogen and Oxygen. The primary risk to the crew appears to be the high-energy fragments and these are being characterized for the SLS. The development efforts will characterize the thermal environment of the explosions as well to ensure that the risk is well understood and to document the overall energy balance of an explosion. The effort is multi-path in that analytical, computational and focused testing is being used to develop the knowledge to understand potential SLS explosions. This is an ongoing program with plans that expand the development from fundamental testing at small-scale levels to large-scale tests that can be used to validate models for commercial programs. The ultimate goal is to develop a knowledge base that can be used by vehicle designers to maximize crew survival in an explosion.

Distinguishing between taskwork and teamwork planning in teams: relations with coordination and interpersonal processes.

PubMed

Fisher, David M

2014-05-01

Planning in teams represents a critical process that lays the groundwork for effective team functioning. The current investigation examined whether emergent team planning can be meaningfully characterized in terms of a distinction between planning that focuses on taskwork and planning that focuses on teamwork. In Study 1, items written to reflect commonly identified indicators of team planning were subjected to an exploratory factor analysis. In Study 2, slightly modified items were provided to a separate sample, and a confirmatory factor analysis was conducted. In Study 3, the relationships between the different forms of planning and other team processes (i.e., coordination, interpersonal processes) were examined in order to determine whether there are unique relationships for task-focused and team-focused planning. Results from the first 2 studies provided support for a 2-factor structure of team planning, whereas Study 3 found independent relationships for taskwork and teamwork planning with subsequent team processes. Both forms of planning also exhibited indirect relationships with team performance via the mediating role of subsequent team processes. (c) 2014 APA, all rights reserved.

Cost of Children in Australia. Institute of Family Studies Working Paper No. 8.

ERIC Educational Resources Information Center

Lovering, Kerry

This report estimates costs of feeding and clothing Australian children at a basic survival level. Detailed information is provided on the types of costs incurred by families at different income levels and with children of different ages. After a brief introduction characterizing the study and summarizing findings, discussion focuses on the…

"It Is More than Just Laughing": Middle School Students Protect Characters during Talk

ERIC Educational Resources Information Center

Onofrey, Karen A.

2006-01-01

The purpose of this qualitative case study was to explore how five middle school students examined humor and characterization used in adolescent literature according to Louise Rosenblatt's (1995) reader response transactional theory. The study was conducted with a focus group of five 6th-grade students, three girls and two boys, from a public…

Cross-Age Peer Tutors in Asynchronous Discussion Groups: Studying the Impact of Tutors Labelling Their Interventions

ERIC Educational Resources Information Center

De Smet, M.; Van Keer, H.; Valcke, M.

2008-01-01

Cross-age tutors were randomly assigned to one of the three tutor training conditions distinguished for the current study: (1) the labelling experimental condition, characterized by requirements to label their tutor interventions, based on the e-moderating model of Salmon; (2) the non-labelling experimental condition, focusing on tutor's acting…

Characterizing behavioural ‘characters’: an evolutionary framework

PubMed Central

Araya-Ajoy, Yimen G.; Dingemanse, Niels J.

2014-01-01

Biologists often study phenotypic evolution assuming that phenotypes consist of a set of quasi-independent units that have been shaped by selection to accomplish a particular function. In the evolutionary literature, such quasi-independent functional units are called ‘evolutionary characters’, and a framework based on evolutionary principles has been developed to characterize them. This framework mainly focuses on ‘fixed’ characters, i.e. those that vary exclusively between individuals. In this paper, we introduce multi-level variation and thereby expand the framework to labile characters, focusing on behaviour as a worked example. We first propose a concept of ‘behavioural characters’ based on the original evolutionary character concept. We then detail how integration of variation between individuals (cf. ‘personality’) and within individuals (cf. ‘individual plasticity’) into the framework gives rise to a whole suite of novel testable predictions about the evolutionary character concept. We further propose a corresponding statistical methodology to test whether observed behaviours should be considered expressions of a hypothesized evolutionary character. We illustrate the application of our framework by characterizing the behavioural character ‘aggressiveness’ in wild great tits, Parus major. PMID:24335984

Three dimensional microstructural characterization of nanoscale precipitates in AA7075-T651 by focused ion beam (FIB) tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Sudhanshu S.; Loza, Jose J.

2016-08-15

The size and distribution of precipitates in Al 7075 alloys affects both the mechanical and corrosion behavior (including stress corrosion cracking and fatigue corrosion) of the alloy. Three dimensional (3D) quantitative microstructural analysis of Al 7075 in the peak aged condition (T651) allows for a better understanding of these behaviors. In this study, Focused ion beam (FIB) tomography was used to characterize the microstructure in three dimensions. Analysis of grains and precipitates was performed in terms of volume, size, and morphology. It was found that the precipitates at the grain boundaries are larger in size, higher in aspect ratios andmore » maximum Feret diameter compared to the precipitates inside the grains, due to earlier nucleation of the precipitates at the grain boundaries. Our data on the precipitates at the interface between grains and Mg{sub 2}Si inclusion show that the surfaces of inclusion (impurity) particles can serve as a location for heterogeneous nucleation of precipitates. - Highlights: •Focused ion beam (FIB) tomography was used to characterize the microstructure of Al 7075 in three dimensions. •Analysis of grains and precipitates was performed in terms of volume, size, and morphology. •Precipitates at the grain boundaries have larger size and aspect ratio compared to the precipitates inside the grains.« less

In Defense of Change Processes

ERIC Educational Resources Information Center

Adolph, Karen E.; Robinson, Scott R

2008-01-01

Nativist and constructivist approaches to the study of development share a common emphasis on characterizing beginning and end states in development. This focus has highlighted the question of preservation and transformation--whether core aspects of the adult end state are present in the earliest manifestations during infancy. In contrast, a…

The Social and Political Structuring of Faculty Ethicality in Education

ERIC Educational Resources Information Center

Reybold, L. Earle

2008-01-01

This study examined the experience of faculty ethicality in education. Research questions focused on faculty characterizations of professional ethics, related socialization experiences, and responses to dilemmas. Interviews were conducted with 32 faculty members and analyzed using the constant comparative method. Findings describe the experiential…

Capturing Flow in the Business Classroom

ERIC Educational Resources Information Center

Guo, Yi Maggie; Ro, Young K.

2008-01-01

This study focuses on the flow experience in business education. Flow experience, characterized by concentration, control, and enjoyment, can lead to better learning outcomes. Leading preconditions of flow include the balance of challenge and skill, feedback, and goal clarity. Other situational factors affect the flow experience through the…

Relearning to Teach Physics: In the Midst of Change.

ERIC Educational Resources Information Center

Wildy, Helen; Wallace, John

1994-01-01

Focuses on the work of one experienced physics teacher and his attempts to come to grips with a new curriculum. This study confirms that change is not a linear process but is characterized by uncertainty, hesitancy, and gradualism. Strategies to help others change are provided. (ZWH)

QUANTITATIVE ASSESSMENT OF CORAL DISEASES IN THE FLORIDA KEYS: STRATEGY AND METHODOLOGY

EPA Science Inventory

Most studies of coral disease have focused on the incidence of a single disease within a single location. Our overall objective is to use quantitative assessments to characterize annual patterns in the distribution and frequency of scleractinian and gorgonian coral diseases over ...

Teaching Science from Cultural Points of Intersection

ERIC Educational Resources Information Center

Grimberg, Bruna Irene; Gummer, Edith

2013-01-01

This study focuses on a professional development program for science teachers near or on American Indian reservations in Montana. This program was framed by culturally relevant pedagogy premises and was characterized by instructional strategies and content foci resulting from the intersection between three cultures: tribal, science teaching, and…

Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions.

PubMed

Thompson, Kimberly M; Odahowski, Cassie L

2016-07-01

Economic analyses for vaccine-preventable diseases provide important insights about the value of prevention. We reviewed the literature to identify all of the peer-reviewed, published economic analyses of interventions related to measles and rubella immunization options to assess the different types of analyses performed and characterize key insights. We searched PubMed, the Science Citation Index, and references from relevant articles for studies in English and found 67 analyses that reported primary data and quantitative estimates of benefit-cost or cost-effectiveness analyses for measles and/or rubella immunization interventions. We removed studies that we characterized as cost-minimization analyses from this sample because they generally provide insights that focused on more optimal strategies to achieve the same health outcome. The 67 analyses we included demonstrate the large economic benefits associated with preventing measles and rubella infections using vaccines and the benefit of combining measles and rubella antigens into a formulation that saves the costs associated with injecting the vaccines separately. Despite the importance of population immunity and dynamic viral transmission, most of the analyses used static models to estimate cases prevented and characterize benefits, although the use of dynamic models continues to increase. Many of the analyses focused on characterizing the most significant adverse outcomes (e.g., mortality for measles, congenital rubella syndrome for rubella) and/or only direct costs, and the most complete analyses present data from high-income countries. © 2014 Society for Risk Analysis.

Development and Characterization of Reference Materials for Genetic Testing: Focus on Public Partnerships.

PubMed

Kalman, Lisa V; Datta, Vivekananda; Williams, Mickey; Zook, Justin M; Salit, Marc L; Han, Jin Yeong

2016-11-01

Characterized reference materials (RMs) are needed for clinical laboratory test development and validation, quality control procedures, and proficiency testing to assure their quality. In this article, we review the development and characterization of RMs for clinical molecular genetic tests. We describe various types of RMs and how to access and utilize them, especially focusing on the Genetic Testing Reference Materials Coordination Program (Get-RM) and the Genome in a Bottle (GIAB) Consortium. This review also reinforces the need for collaborative efforts in the clinical genetic testing community to develop additional RMs.

Multiscale microstructural characterization of Sn-rich alloys by three dimensional (3D) X-ray synchrotron tomography and focused ion beam (FIB) tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yazzie, K.E.; Williams, J.J.; Phillips, N.C.

2012-08-15

Sn-rich (Pb-free) alloys serve as electrical and mechanical interconnects in electronic packaging. It is critical to quantify the microstructures of Sn-rich alloys to obtain a fundamental understanding of their properties. In this work, the intermetallic precipitates in Sn-3.5Ag and Sn-0.7Cu, and globular lamellae in Sn-37Pb solder joints were visualized and quantified using 3D X-ray synchrotron tomography and focused ion beam (FIB) tomography. 3D reconstructions were analyzed to extract statistics on particle size and spatial distribution. In the Sn-Pb alloy the interconnectivity of Sn-rich and Pb-rich constituents was quantified. It will be shown that multiscale characterization using 3D X-ray and FIBmore » tomography enabled the characterization of the complex morphology, distribution, and statistics of precipitates and contiguous phases over a range of length scales. - Highlights: Black-Right-Pointing-Pointer Multiscale characterization by X-ray synchrotron and focused ion beam tomography. Black-Right-Pointing-Pointer Characterized microstructural features in several Sn-based alloys. Black-Right-Pointing-Pointer Quantified size, fraction, and clustering of microstructural features.« less

Hydrodynamic focusing investigation in a micro-flow cytometer.

PubMed

Yang, An-Shik; Hsieh, Wen-Hsin

2007-04-01

Hydrodynamic focusing behavior is characterized by two fluids coflowing at different velocities inside a micro-flow cytometer. In this study, a two-fluid model has been established to describe the flow transport behavior and interaction of sample and sheath fluids. The analysis treats the sample and sheath fluids as two-dimensional, laminar, incompressible, and isothermal. The theoretical model comprises two groups of transient conservation equations of mass and momentum with consideration of the interfacial momentum exchange. The governing equations are solved numerically through an iterative SIMPLEC algorithm to determine the flow properties. Since the ratio of the sheath velocity to the sample velocity varies from 5 to 70, the predicted focusing width and length are in good agreement with the experimental data in the literature. In addition, the present study explored the hydrodynamic focusing flowfield as well as the pressure drop across a micro-flow cytometer and the time needed for the completion of one focusing event in detail. To enhance the understanding of hydrodynamic focusing in the design of cytometers, ten numerical experiments were conducted to examine the effects of the inner nozzle length, inner nozzle exit width, inner nozzle shape, and fluid properties on the width of the focused sample stream.

When gender bumps into health and safety training: working conditions, readings and challenges drawn from a case study in an industrial chemicals company.

PubMed

Vasconcelos, Ricardo; Teixeira, Sandra; Castelhano, Joana; Lacomblez, Marianne

2012-01-01

Health, safety and environmental issues are at present a social concern and an increasingly referred topic in the so called gender studies. This paper focuses on the relations between training, gender and risk perception in an industrial chemicals company, in Portugal, characterized by a mainly male population and by the presence of high occupational and environmental hazards. After characterizing the company and the training project that started up this reflection, the paper presents the reasons for its focus on gender followed by the essential methodological explanations: 14 interviews were made with male and female workers from the company; their content was transcribed from the audio recordings and it was systematically analyzed. A gender-attentive socio demographic analysis was also undertaken. Although at the beginning the company did not consider the gender issues as a problem nor was it the central topic of the training, which focused on the prevention of occupational and environmental hazards, the results reveal that the gender factor brought to light some working conditions, which so far have not been properly discussed within the group meetings. As a consequence, there is now room for the transformation of the representations on those working conditions.

A Comparative Study of Allusions in the Poetry of English Poet John Milton and Persian Poet Hafiz Sherazi

ERIC Educational Resources Information Center

Saleem, Tahir

2015-01-01

Comparative literary studies characterize similarities and dissimilarities found in poetic works of two writers of different cultures. This study focuses on the use of allusions in poetry of John Milton particularly with reference to Paradise Lost and poetry of Persian Poet Hafiz Sherazi. Using allusions in poetry has been a common style of poets…

Proton Therapy Dose Characterization and Verification

DTIC Science & Technology

2016-10-01

than recommended as these patients are on a separate UPENN research study where dose maximum accepted was 6700 cGy. 15... Research Protection Office. 8.0 Data Handling and Record Keeping All patients must have a signed Informed Consent Form and an On - study (confirmation...this award. Phase 1 concentrated on designing and building a Multi-leaf collimator for use in proton therapy. Phase 2 focused on studying the

Characterization of Dispersive Ultrasonic Rayleigh Surface Waves in Asphalt Concrete

NASA Astrophysics Data System (ADS)

In, Chi-Won; Kim, Jin-Yeon; Jacobs, Laurence J.; Kurtis, Kimberly E.

2008-02-01

This research focuses on the application of ultrasonic Rayleigh surface waves to nondestructively characterize the mechanical properties and structural defects (non-uniformly distributed aggregate) in asphalt concrete. An efficient wedge technique is developed in this study to generate Rayleigh surface waves that is shown to be effective in characterizing Rayleigh waves in this highly viscoelastic (attenuating) and heterogeneous medium. Experiments are performed on an asphalt-concrete beam produced with uniformly distributed aggregate. Ultrasonic techniques using both contact and non-contact sensors are examined and their results are compared. Experimental results show that the wedge technique along with an air-coupled sensor appears to be effective in characterizing Rayleigh waves in asphalt concrete. Hence, measurement of theses material properties needs to be investigated in non-uniformly distributed aggregate material using these techniques.

A review of microelectromechanical systems for nanoscale mechanical characterization

NASA Astrophysics Data System (ADS)

Zhu, Yong; Chang, Tzu-Hsuan

2015-09-01

A plethora of nanostructures with outstanding properties have emerged over the past decades. Measuring their mechanical properties and understanding their deformation mechanisms is of paramount importance for many of their device applications. To address this need innovative experimental techniques have been developed, among which a promising one is based upon microelectromechanical systems (MEMS). This article reviews the recent advances in MEMS platforms for the mechanical characterization of one-dimensional (1D) nanostructures over the past decade. A large number of MEMS platforms and related nanomechanics studies are presented to demonstrate the unprecedented capabilities of MEMS for nanoscale mechanical characterization. Focusing on key design considerations, this article aims to provide useful guidelines for developing MEMS platforms. Finally, some of the challenges and future directions in the area of MEMS-enabled nanomechanical characterization are discussed.

FY12 End of Year Report for NEPP DDR2 Reliability

NASA Technical Reports Server (NTRS)

Guertin, Steven M.

2013-01-01

This document reports the status of the NASA Electronic Parts and Packaging (NEPP) Double Data Rate 2 (DDR2) Reliability effort for FY2012. The task expanded the focus of evaluating reliability effects targeted for device examination. FY11 work highlighted the need to test many more parts and to examine more operating conditions, in order to provide useful recommendations for NASA users of these devices. This year's efforts focused on development of test capabilities, particularly focusing on those that can be used to determine overall lot quality and identify outlier devices, and test methods that can be employed on components for flight use. Flight acceptance of components potentially includes considerable time for up-screening (though this time may not currently be used for much reliability testing). Manufacturers are much more knowledgeable about the relevant reliability mechanisms for each of their devices. We are not in a position to know what the appropriate reliability tests are for any given device, so although reliability testing could be focused for a given device, we are forced to perform a large campaign of reliability tests to identify devices with degraded reliability. With the available up-screening time for NASA parts, it is possible to run many device performance studies. This includes verification of basic datasheet characteristics. Furthermore, it is possible to perform significant pattern sensitivity studies. By doing these studies we can establish higher reliability of flight components. In order to develop these approaches, it is necessary to develop test capability that can identify reliability outliers. To do this we must test many devices to ensure outliers are in the sample, and we must develop characterization capability to measure many different parameters. For FY12 we increased capability for reliability characterization and sample size. We increased sample size this year by moving from loose devices to dual inline memory modules (DIMMs) with an approximate reduction of 20 to 50 times in terms of per device under test (DUT) cost. By increasing sample size we have improved our ability to characterize devices that may be considered reliability outliers. This report provides an update on the effort to improve DDR2 testing capability. Although focused on DDR2, the methods being used can be extended to DDR and DDR3 with relative ease.

Strengthening the Focus on Business Results: The Need for Systems Approaches in Organizational Behavior Management

ERIC Educational Resources Information Center

Hyten, Cloyd

2009-01-01

Current Organizational Behavior Management (OBM) research and practice may be characterized as either behavior focused or results focused. These two approaches stem from different origins and have different characteristics. The behavior-focused approach stems from applied behavior analysis (ABA) methods and emphasizes direct observation of and…

Stratocumulus Precipitation and Entrainment Experiment (SPEE) Field Campaign Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albrecht, Bruce; Ghate, Virendra; CADeddu, Maria

2016-06-01

The scientific focus of this project was to examine precipitation and entrainment processes in marine stratocumulus clouds. The entrainment studies focused on characterizing cloud turbulence at cloud top using Doppler cloud radar observations. The precipitation studies focused on characterizing the precipitation and the macroscopic properties (cloud thickness, and liquid water path) of the clouds. This project will contribute to the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility’s overall objective of providing the remote-sensing observations needed to improve the representation of key cloud processes in climate models. It will be of direct relevance to the componentsmore » of ARM dealing with entrainment and precipitation processes in stratiform clouds. Further, the radar observing techniques that will be used in this study were developed using ARM Southern Great Plains (SGP) facility observations under Atmospheric System Research (ASR) support. The observing systems operating automatously from a site located just north of the Center for Interdisciplinary Remotely-Piloted Aircraft Studies (CIRPAS) aircraft hangar in Marina, California during the period of 1 May to 4 November 2015 included: 1. Microwave radiometer: ARM Microwave Radiometer, 3-Channel (MWR3C) with channels centered at 23.834, 30, and 89 GHz; supported by Dr. Maria Cadeddu. 2. Cloud Radar: CIRPAS 95 GHz Frequency Modulated Continuous Wave (FMCW) Cloud Radar (Centroid Frequency Chirp Rate [CFCR]); operations overseen by Drs. Ghate and Albrecht. 3. Ceilometer: Vaisala CK-14; operations overseen by Drs. Ghate and Albrecht.« less

Publication trend, resource utilization, and impact of the US National Cancer Database: A systematic review.

PubMed

Su, Chang; Peng, Cuiying; Agbodza, Ena; Bai, Harrison X; Huang, Yuqian; Karakousis, Giorgos; Zhang, Paul J; Zhang, Zishu

2018-03-01

The utilization and impact of the studies published using the National Cancer Database (NCDB) is currently unclear. In this study, we aim to characterize the published studies, and identify relatively unexplored areas for future investigations. A literature search was performed using PubMed in January 2017 to identify all papers published using NCDB data. Characteristics of the publications were extracted. Citation frequencies were obtained through the Web of Science. Three hundred 2 articles written by 230 first authors met the inclusion criteria. The number of publications grew exponentially since 2013, with 108 articles published in 2016. Articles were published in 86 journals. The majority of the published papers focused on digestive system cancer, while bone and joints, eye and orbit, myeloma, mesothelioma, and Kaposi Sarcoma were never studied. Thirteen institutions in the United States were associated with more than 5 publications. The papers have been cited for a total of 9858 times since the publication of the first paper in 1992. Frequently appearing keywords congregated into 3 clusters: "demographics," "treatments and survival," and "statistical analysis method." Even though the main focuses of the articles captured a extremely wide range, they can be classified into 2 main categories: survival analysis and characterization. Other focuses include database(s) analysis and/or comparison, and hospital reporting. The surging interest in the use of NCDB is accompanied by unequal utilization of resources by individuals and institutions. Certain areas were relatively understudied and should be further explored.

Characterization of the Ecosole HCPV tracker and single module inverter

NASA Astrophysics Data System (ADS)

Carpanelli, Maurizio; Borelli, Gianni; Verdilio, Daniele; De Nardis, Davide; Migali, Fabrizio; Cancro, Carmine; Graditi, Giorgio

2015-09-01

BECAR, the Beghelli group's R&D company, is leading ECOSOLE (Elevated COncentration SOlar Energy), one of the largest European Demonstration projects in solar photovoltaic. ECOSOLE, started in 2012, is focused on the study, design, and realization of new HCPV generator made of high efficiency PV modules equipped with SoG (Silicone on Glass) fresnel lenses and III-V solar cells, and a low cost matched solar tracker with distributed inverters approach. The project also regards the study and demonstration of new high throughput methods for the industrial large scale productions, at very low manufacturing costs. This work reports the description of the characterization of the tracker and single module.

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for NASA Glenn Research Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Stephen; Francfort, Jim

The Advanced Vehicle Testing Activity’s study seeks to collect and evaluate data to validate the utilization of advanced plug-in electric vehicle (PEV) transportation. This report focuses on the NASA Glenn Research Center (GRC) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.

Teacher's Representational Fluency in a Context of Technology Use

ERIC Educational Resources Information Center

Rocha, Helena

2016-01-01

This study focuses on teacher's Knowledge for Teaching Mathematics with Technology (KTMT), paying a special attention to teacher's representational fluency. It intends to characterize how the teacher uses and integrates the different representations provided by the graphing calculator on the process of teaching and learning functions at the high…

Solar-powered air-conditioning

NASA Technical Reports Server (NTRS)

Clark, D. C.; Rousseau, J.

1977-01-01

Report focuses on recent study on development of solar-powered residential air conditioners and is based on selected literature through 1975. Its purposes are to characterize thermal and mechanical systems that might be useful in development of Rankine-cycle approach to solar cooling and assessment of a Lithium Bromide/Water absorption cycle system.

Gender, Sibship Composition, and Education in Egypt

ERIC Educational Resources Information Center

Tfaily, Rania

2016-01-01

This article examines the relationship between gender, sibship, and education over time in Egypt, focusing on how the number, sex, and birth order configuration of siblings affected boys' and girls' education during 1991-2008, a period characterized by significant social and economic changes in Egypt. This study disaggregates schooling into…

Characterizing Mathematics Classroom Practice: Impact of Observation and Coding Choices

ERIC Educational Resources Information Center

Ing, Marsha; Webb, Noreen M.

2012-01-01

Large-scale observational measures of classroom practice increasingly focus on opportunities for student participation as an indicator of instructional quality. Each observational measure necessitates making design and coding choices on how to best measure student participation. This study investigated variations of coding approaches that may be…

[beta]-Lactamases in the Biochemistry and Molecular Biology Laboratory

ERIC Educational Resources Information Center

Amador, Paula; Prudencio, Cristina; Vieira, Monica; Ferraz, Ricardo; Fonte, Rosalia; Silva, Nuno; Coelho, Pedro; Fernandes, Ruben

2009-01-01

[beta]-lactamases are hydrolytic enzymes that inactivate the [beta]-lactam ring of antibiotics such as penicillins and cephalosporins. The major diversity of studies carried out until now have mainly focused on the characterization of [beta]-lactamases recovered among clinical isolates of Gram-positive staphylococci and Gram-negative…

Documentation and Communication in Swedish Preschools

ERIC Educational Resources Information Center

Emilson, Anette; Pramling Samuelsson, Ingrid

2014-01-01

The aim of this study is to investigate communication between preschool teachers and children in documentation situations. The focus is also on what preschool teachers actually document. The research questions are: What characterizes the communication between teachers and children when these teachers are documenting at the same time? What is the…

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in beta-Catenin-Active Cancers | Office of Cancer Genomics

Cancer.gov

Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches.

Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities

EPA Science Inventory

The objective of the present study is to review current knowledge regarding the bioaccumulation potential of IOCs, with a focus on the availability of empirical data for fish. Aspects of the bioaccumulation potential of IOCs in fish that can be characterized relatively well inclu...

Evaluating Youth Work with Vulnerable Young People.

ERIC Educational Resources Information Center

Furlong, Andy; Cartmel, Fred; Powney, Janet; Hall, Stuart

This report presents the results of an 18-month research project that studied the effectiveness of youth work with vulnerable young people. The research, representing six distinct geographical areas of Scotland characterized by disadvantage, focused on young people aged 13 to 16. In each neighborhood, the project examined the experiences of young…

Sustaining Education for Sustainability in Turbulent Times

ERIC Educational Resources Information Center

Smith, Gregory A.; Stevenson, Robert B.

2017-01-01

A study of two schools in northern Australia demonstrated the impact on Education for Sustainability (EfS) initiatives of a disruptive policy environment set in motion by neoliberal reforms focused on standards, accountability, and international competitiveness. In one of the schools, a culture characterized by trust and an emphasis on cultivating…

ASSESSING TCDD WASTING SYNDROME IN AN IN VIVO OBESITY MODEL

EPA Science Inventory

TCDD is a by-product of incineration commonly found as a microcontaminant in the food supply. The TCDD wasting syndrome, characterized by prolonged weight loss, has been examined for decades. Much of this work has focused on high dose in vivo and in vitro studies....

The Management of Retrenchment in Canadian Academic Libraries.

ERIC Educational Resources Information Center

Denis, Laurent-G.; Auster, Ethel

This exploratory study focuses on the management of decline as characterized by shrinking resources and substantial reductions in operating budgets (retrenchment) in academic research libraries in Canada. The first of four major sections of the report addresses the management of retrenchment in Canadian research libraries, including the design of…

Empowerment in Science Curriculum Development: A Microdevelopmental Approach

ERIC Educational Resources Information Center

Schwartz, Marc S.; Sadler, Philip M.

2007-01-01

This study characterizes how learning and teaching differs as the responsibility for choosing curriculum goals and the strategies to reach those goals shifts between teacher and the students. Three different pedagogical approaches were used with 125 seventh-grade and eighth-grade students. All three curricula focus on electromagnetism, and were…

The Skills Agenda: Issues for Post-16 Providers. FEDA Comments.

ERIC Educational Resources Information Center

Hughes, Maria; Mager, Caroline

Studies in Great Britain have focused on the rapidly changing economy of the 21st century and the skills that workers will need to contribute to it. The studies have found that the new century will be characterized by the knowledge-driven economy, changes driven by global markets, the rapid movement of finance, and developments in information and…

The Use of Biofeedback in Treating the Self-Mutilative Behaviors of a Child with Lesch-Nyhan Syndrome: A Pilot Study.

ERIC Educational Resources Information Center

Carmen, Jeffrey A.; And Others

The pilot study focused on the effective design of adaptive biofeedback equipment for use in the control of self-mutilating behaviors in individuals with Lesch-Nyhan syndrome, typically characterized by apasticity, mental retardation, and violent biting of the lips and fingers. Utilizing an electromyographic (EMG) monitor and a custom-designed…

Acceptance and Continuance Factors Associated with Mobile Medical App Use: A Qualitative Case Study of Diabetes Apps

ERIC Educational Resources Information Center

MacDonald, Amy Joy

2017-01-01

Despite advances in smartphone technologies and development of myriad apps that can support self-management efforts for chronic disease like diabetes, initial acceptance of such apps by actual users was characterized by low consistent use by these users. Few studies conducted by researchers on acceptance and use outcomes of mobile apps focused on…

Fabrication of nanoelectrodes for neurophysiology: cathodic electrophoretic paint insulation and focused ion beam milling

PubMed Central

Qiao, Yi; Chen, Jie; Guo, Xiaoli; Cantrell, Donald; Ruoff, Rodney; Troy, John

2005-01-01

The fabrication and characterization of tungsten nanoelectrodes insulated with cathodic electrophoretic paint is described together with their application within the field of neurophysiology. The tip of a 127 μm diameter tungsten wire was etched down to less than 100 nm and then insulated with cathodic electrophoretic paint. Focused ion beam (FIB) polishing was employed to remove the insulation at the electrode’s apex, leaving a nanoscale sized conductive tip of 100–1000 nm. The nanoelectrodes were examined by scanning electron microscopy (SEM) and their electrochemical properties characterized by steady state linear sweep voltammetry. Electrode impedance at 1 kHz was measured too. The ability of a 700 nm tipped electrode to record well-isolated action potentials extracellularly from single visual neurons in vivo was demonstrated. Such electrodes have the potential to open new populations of neurons to study. PMID:16467926

Polymeric nanoparticles: A study on the preparation variables and characterization methods.

PubMed

Crucho, Carina I C; Barros, Maria Teresa

2017-11-01

Since the emergence of Nanotechnology in the past decades, the development and design of nanomaterials has become an important field of research. An emerging component in this field is nanomedicine, wherein nanoscale materials are being developed for use as imaging agents or for drug delivery applications. Much work is currently focused in the preparation of well-defined nanomaterials in terms of size and shape. These factors play a significantly role in the nanomaterial behavior in vivo. In this context, this review focuses on the toolbox of available methods for the preparation of polymeric nanoparticles. We highlight some recent examples from the literature that demonstrate the influence of the preparation method on the physicochemical characteristics of the nanoparticles. Additionally, in the second part, the characterization methods for this type of nanoparticles are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

Task-focused behavior mediates the associations between supportive interpersonal environments and students' academic performance.

PubMed

Kiuru, Noona; Pakarinen, Eija; Vasalampi, Kati; Silinskas, Gintautas; Aunola, Kaisa; Poikkeus, Anna-Maija; Metsäpelto, Riitta-Leena; Lerkkanen, Marja-Kristiina; Nurmi, Jari-Erik

2014-04-01

In the longitudinal study presented here, we tested the theoretical assumption that children's task-focused behavior in learning situations mediates the associations between supportive interpersonal environments and academic performance. The sample consisted of 2,137 Finnish-speaking children. Data on supportive interpersonal environments (characterized by authoritative parenting, positive teacher affect toward the child, and peer acceptance) were gathered in Grade 1. The children's task-focused behavior was measured in Grades 2 and 3, and academic performance was measured in Grades 1 and 4. The results supported our assumption by showing that all three supportive environments were positively associated with children's subsequent academic performance via increased task-focused behavior in learning situations. These findings suggest that students' academic performance can be promoted by increasing the support they receive from peers, parents, and teachers because such increased support leads to better task focus in learning tasks.

Integrated spatiotemporal characterization of dust sources and outbreaks in Central and East Asia

NASA Astrophysics Data System (ADS)

Darmenova, Kremena T.

The potential of atmospheric dust aerosols to modify the Earth's environment and climate has been recognized for some time. However, predicting the diverse impact of dust has several significant challenges. One is to quantify the complex spatial and temporal variability of dust burden in the atmosphere. Another is to quantify the fraction of dust originating from human-made sources. This thesis focuses on the spatiotemporal characterization of sources and dust outbreaks in Central and East Asia by integrating ground-based data, satellite multisensor observations, and modeling. A new regional dust modeling system capable of operating over a span of scales was developed. The modeling system consists of a dust module DuMo, which incorporates several dust emission schemes of different complexity, and the PSU/NCAR mesoscale model MM5, which offers a variety of physical parameterizations and flexible nesting capability. The modeling system was used to perform for the first time a comprehensive study of the timing, duration, and intensity of individual dust events in Central and East Asia. Determining the uncertainties caused by the choice of model physics, especially the boundary layer parameterization, and the dust production scheme was the focus of our study. Implications to assessments of the anthropogenic dust fraction in these regions were also addressed. Focusing on Spring 2001, an analysis of routine surface meteorological observations and satellite multi-sensor data was carried out in conjunction with modeling to determine the extent to which integrated data set can be used to characterize the spatiotemporal distribution of dust plumes at a range of temporal scales, addressing the active dust sources in China and Mongolia, mid-range transport and trans-Pacific, long-range transport of dust outbreaks on a case-by-case basis. This work demonstrates that adequate and consistent characterization of individual dust events is central to establishing a reliable climatology, ultimately leading to improved assessments of dust impacts on the environment and climate. This will also help to identify the appropriate temporal and spatial scales for adequate intercomparison between model results and observational data as well as for developing an integrated analysis methodology for dust studies.

Laboratory Studies on Surface Sampling of Bacillus anthracis Contamination: Summary, Gaps, and Recommendations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piepel, Gregory F.; Amidan, Brett G.; Hu, Rebecca

2011-11-28

This report summarizes previous laboratory studies to characterize the performance of methods for collecting, storing/transporting, processing, and analyzing samples from surfaces contaminated by Bacillus anthracis or related surrogates. The focus is on plate culture and count estimates of surface contamination for swab, wipe, and vacuum samples of porous and nonporous surfaces. Summaries of the previous studies and their results were assessed to identify gaps in information needed as inputs to calculate key parameters critical to risk management in biothreat incidents. One key parameter is the number of samples needed to make characterization or clearance decisions with specified statistical confidence. Othermore » key parameters include the ability to calculate, following contamination incidents, the (1) estimates of Bacillus anthracis contamination, as well as the bias and uncertainties in the estimates, and (2) confidence in characterization and clearance decisions for contaminated or decontaminated buildings. Gaps in knowledge and understanding identified during the summary of the studies are discussed and recommendations are given for future studies.« less

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for Department of Veterans Affairs – VA Manhattan Campus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephen Schey; Jim Francfort

2014-10-01

This report focuses on the Department of Veterans Affairs, VA Manhattan Campus (VA- Manhattan) fleet to identify the daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support successful introduction of plug-in electric vehicles (PEVs) into the agency’s fleet. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively called PEVs) can fulfill the mission requirements.

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for NASA White Sands Test Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Stephen; Francfort, Jim

This report focuses on the NASA White Sands Test Facility (WSTF) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of plug-in electric vehicles (PEVs) into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle (BEV) or plug-in hybrid electric vehicle (PHEV) (collectively plug-in electric vehicles, or PEVs) can fulfill the mission requirements.

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for National Institute of Health

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Stephen; Francfort, Jim

2014-11-01

This report focuses on the National Institute of Health (NIH) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of plug-in electric vehicles (PEVs) into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle (BEV) or plug-in hybrid electric vehicle (PHEV) (collectively plug-in electric vehicles, or PEVs) can fulfill the mission requirements.

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for Department of Health and Human Services – ASPR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Steve; Francfort, Jim

2015-06-01

This report focuses on the Department of Health and Human Services, Assistant Secretary for Preparedness and Response fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agency’s fleet. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.

The Protective Roles of the Antioxidant Enzymes Superoxide Dismutase and Catalase in the Green Photosynthetic Bacterium Chloroflexus Aurantiacus

NASA Technical Reports Server (NTRS)

Blankenship, Robert E.; Rothschild, Lynn (Technical Monitor)

2004-01-01

The purpose of this study was to examine the biochemical response of the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus to oxidative stress. Lab experiments focused primarily on characterizing the antioxidant enzyme superoxide dismutase and the response of this organism to oxidative stress. Experiments in the field at the hotsprings in Yellowstone National Park focused on the changes in the level of these enzymes during the day in response to oxidants and to the different types of ultraviolet radiation.

Controlling Magnetic and Ferroelectric Order Through Geometry: Synthesis, Ab Initio Theory, Characterization of New Multi-Ferric Fluoride Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halasyamani, Shiv; Fennie, Craig

2016-11-03

We have focused on the synthesis, characterization, and ab initio theory on multi-functional mixed-metal fluorides. With funding from the DOE, we have successfully synthesized and characterized a variety of mixed metal fluoride materials.

Benefits of utilizing CellProfiler as a characterization tool for U–10Mo nuclear fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collette, R.; Douglas, J.; Patterson, L.

2015-07-15

Automated image processing techniques have the potential to aid in the performance evaluation of nuclear fuels by eliminating judgment calls that may vary from person-to-person or sample-to-sample. Analysis of in-core fuel performance is required for design and safety evaluations related to almost every aspect of the nuclear fuel cycle. This study presents a methodology for assessing the quality of uranium–molybdenum fuel images and describes image analysis routines designed for the characterization of several important microstructural properties. The analyses are performed in CellProfiler, an open-source program designed to enable biologists without training in computer vision or programming to automatically extract cellularmore » measurements from large image sets. The quality metric scores an image based on three parameters: the illumination gradient across the image, the overall focus of the image, and the fraction of the image that contains scratches. The metric presents the user with the ability to ‘pass’ or ‘fail’ an image based on a reproducible quality score. Passable images may then be characterized through a separate CellProfiler pipeline, which enlists a variety of common image analysis techniques. The results demonstrate the ability to reliably pass or fail images based on the illumination, focus, and scratch fraction of the image, followed by automatic extraction of morphological data with respect to fission gas voids, interaction layers, and grain boundaries. - Graphical abstract: Display Omitted - Highlights: • A technique is developed to score U–10Mo FIB-SEM image quality using CellProfiler. • The pass/fail metric is based on image illumination, focus, and area scratched. • Automated image analysis is performed in pipeline fashion to characterize images. • Fission gas void, interaction layer, and grain boundary coverage data is extracted. • Preliminary characterization results demonstrate consistency of the algorithm.« less

Habit Reversal Therapy for Body-Focused Repetitive Behaviors in Williams Syndrome: A Case Study

PubMed Central

Klein-Tasman, Bonita P.

2013-01-01

Williams syndrome (WS) is genetic neurodevelopmental disorder with a well-characterized cognitive and behavioral phenotype. Research has consistently demonstrated high rates of psychopathology in this population; however, little research has examined the use of empirically-supported psychosocial interventions in those with WS. The current case study reports on the use of Habit Reversal Therapy (HRT) to treat multiple body-focused repetitive behaviors in a child with WS. Although HRT is a well-established cognitive-behavioral intervention for body-focused repetitive behaviors, it has been infrequently used in populations with developmental disabilities. An etiologically-informed approach was used to adapt HRT to fit the known behavioral and cognitive phenotype of WS. Results suggest that HRT may be beneficial for this population. Modified treatment elements are described and future research areas highlighted. PMID:24357918

Explanation and relations. How do general practitioners deal with patients with persistent medically unexplained symptoms: a focus group study

PubMed Central

olde Hartman, Tim C; Hassink-Franke, Lieke J; Lucassen, Peter L; van Spaendonck, Karel P; van Weel, Chris

2009-01-01

Background Persistent presentation of medically unexplained symptoms (MUS) is troublesome for general practitioners (GPs) and causes pressure on the doctor-patient relationship. As a consequence, GPs face the problem of establishing an ongoing, preferably effective relationship with these patients. This study aims at exploring GPs' perceptions about explaining MUS to patients and about how relationships with these patients evolve over time in daily practice. Methods A qualitative approach, interviewing a purposive sample of twenty-two Dutch GPs within five focus groups. Data were analyzed according to the principles of constant comparative analysis. Results GPs recognise the importance of an adequate explanation of the diagnosis of MUS but often feel incapable of being able to explain it clearly to their patients. GPs therefore indicate that they try to reassure patients in non-specific ways, for example by telling patients that there is no disease, by using metaphors and by normalizing the symptoms. When patients keep returning with MUS, GPs report the importance of maintaining the doctor-patient relationship. GPs describe three different models to do this; mutual alliance characterized by ritual care (e.g. regular physical examination, regular doctor visits) with approval of the patient and the doctor, ambivalent alliance characterized by ritual care without approval of the doctor and non-alliance characterized by cutting off all reasons for encounter in which symptoms are not of somatic origin. Conclusion GPs feel difficulties in explaining the symptoms. GPs report that, when patients keep presenting with MUS, they focus on maintaining the doctor-patient relationship by using ritual care. In this care they meticulously balance between maintaining a good doctor-patient relationship and the prevention of unintended consequences of unnecessary interventions. PMID:19775481

On Improving the Quality and Interpretation of Environmental Assessments using Statistical Analysis and Geographic Information Systems

NASA Astrophysics Data System (ADS)

Karuppiah, R.; Faldi, A.; Laurenzi, I.; Usadi, A.; Venkatesh, A.

2014-12-01

An increasing number of studies are focused on assessing the environmental footprint of different products and processes, especially using life cycle assessment (LCA). This work shows how combining statistical methods and Geographic Information Systems (GIS) with environmental analyses can help improve the quality of results and their interpretation. Most environmental assessments in literature yield single numbers that characterize the environmental impact of a process/product - typically global or country averages, often unchanging in time. In this work, we show how statistical analysis and GIS can help address these limitations. For example, we demonstrate a method to separately quantify uncertainty and variability in the result of LCA models using a power generation case study. This is important for rigorous comparisons between the impacts of different processes. Another challenge is lack of data that can affect the rigor of LCAs. We have developed an approach to estimate environmental impacts of incompletely characterized processes using predictive statistical models. This method is applied to estimate unreported coal power plant emissions in several world regions. There is also a general lack of spatio-temporal characterization of the results in environmental analyses. For instance, studies that focus on water usage do not put in context where and when water is withdrawn. Through the use of hydrological modeling combined with GIS, we quantify water stress on a regional and seasonal basis to understand water supply and demand risks for multiple users. Another example where it is important to consider regional dependency of impacts is when characterizing how agricultural land occupation affects biodiversity in a region. We developed a data-driven methodology used in conjuction with GIS to determine if there is a statistically significant difference between the impacts of growing different crops on different species in various biomes of the world.

The Survival of Arts Education in the NCLB Era: A Case Study of One K-8th Grade Arts-Focused Charter School in a California Program Improvement School District

ERIC Educational Resources Information Center

Kratochvil, Kathie R.

2009-01-01

This research study presents one in-depth case study that investigates the successes, challenges, and processes of developing and enacting arts education programming at the elementary school level given the time limitations and other constraints associated with the high stakes testing environment that currently characterizes many of California's…

Leadership development programs for physicians: a systematic review.

PubMed

Frich, Jan C; Brewster, Amanda L; Cherlin, Emily J; Bradley, Elizabeth H

2015-05-01

Physician leadership development programs typically aim to strengthen physicians' leadership competencies and improve organizational performance. We conducted a systematic review of medical literature on physician leadership development programs in order to characterize the setting, educational content, teaching methods, and learning outcomes achieved. Articles were identified through a search in Ovid MEDLINE from 1950 through November 2013. We included articles that described programs designed to expose physicians to leadership concepts, outlined teaching methods, and reported evaluation outcomes. A thematic analysis was conducted using a structured data entry form with categories for setting/target group, educational content, format, type of evaluation and outcomes. We identified 45 studies that met eligibility criteria, of which 35 reported on programs exclusively targeting physicians. The majority of programs focused on skills training and technical and conceptual knowledge, while fewer programs focused on personal growth and awareness. Half of the studies used pre/post intervention designs, and four studies used a comparison group. Positive outcomes were reported in all studies, although the majority of studies relied on learner satisfaction scores and self-assessed knowledge or behavioral change. Only six studies documented favorable organizational outcomes, such as improvement in quality indicators for disease management. The leadership programs examined in these studies were characterized by the use of multiple learning methods, including lectures, seminars, group work, and action learning projects in multidisciplinary teams. Physician leadership development programs are associated with increased self-assessed knowledge and expertise; however, few studies have examined outcomes at a system level. Our synthesis of the literature suggests important gaps, including a lack of programs that integrate non-physician and physician professionals, limited use of more interactive learning and feedback to develop greater self-awareness, and an overly narrow focus on individual-level rather than system-level outcomes.

Ronchi test for characterization of nanofocusing optics at a hard x-ray free-electron laser.

PubMed

Nilsson, Daniel; Uhlén, Fredrik; Holmberg, Anders; Hertz, Hans M; Schropp, Andreas; Patommel, Jens; Hoppe, Robert; Seiboth, Frank; Meier, Vivienne; Schroer, Christian G; Galtier, Eric; Nagler, Bob; Lee, Hae Ja; Vogt, Ulrich

2012-12-15

We demonstrate the use of the classical Ronchi test to characterize aberrations in focusing optics at a hard x-ray free-electron laser. A grating is placed close to the focus and the interference between the different orders after the grating is observed in the far field. Any aberrations in the beam or the optics will distort the interference fringes. The method is simple to implement and can provide single-shot information about the focusing quality. We used the Ronchi test to measure the aberrations in a nanofocusing Fresnel zone plate at the Linac Coherent Light Source at 8.194 keV.

HIFU Transducer Characterization Using a Robust Needle Hydrophone

NASA Astrophysics Data System (ADS)

Howard, Samuel M.; Zanelli, Claudio I.

2007-05-01

A robust needle hydrophone has been developed for HIFU transducer characterization and reported on earlier. After a brief review of the hydrophone design and performance, we demonstrate its use to characterize a 1.5 MHz, 10 cm diameter, F-number 1.5 spherically focused source driven to exceed an intensity of 1400 W/cm2at its focus. Quantitative characterization of this source at high powers is assisted by deconvolving the hydrophone's calibrated frequency response in order to accurately reflect the contribution of harmonics generated by nonlinear propagation in the water testing environment. Results are compared to measurements with a membrane hydrophone at 0.3% duty cycle and to theoretical calculations, using measurements of the field at the source's radiating surface as input to a numerical solution of the KZK equation.

Physical interpretation and development of ultrasonic nondestructive evaluation techniques applied to the quantitative characterization of textile composite materials

NASA Technical Reports Server (NTRS)

Miller, James G.

1993-01-01

In this Progress Report, we describe our current research activities concerning the development and implementation of advanced ultrasonic nondestructive evaluation methods applied to the characterization of stitched composite materials and bonded aluminum plate specimens. One purpose of this investigation is to identify and characterize specific features of polar backscatter interrogation which enhance the ability of ultrasound to detect flaws in a stitched composite laminate. Another focus is to explore the feasibility of implementing medical linear array imaging technology as a viable ultrasonic-based nondestructive evaluation method to inspect and characterize bonded aluminum lap joints. As an approach to implementing quantitative ultrasonic inspection methods to both of these materials, we focus on the physics that underlies the detection of flaws in such materials.

Home composting versus industrial composting: influence of composting system on compost quality with focus on compost stability.

PubMed

Barrena, Raquel; Font, Xavier; Gabarrell, Xavier; Sánchez, Antoni

2014-07-01

Stability is one of the most important properties of compost obtained from the organic fraction of municipal solid wastes. This property is essential for the application of compost to land to avoid further field degradation and emissions of odors, among others. In this study, a massive characterization of compost samples from both home producers and industrial facilities is presented. Results are analyzed in terms of chemical and respiration characterizations, the latter representing the stability of the compost. Results are also analyzed in terms of statistical validation. The main conclusion from this work is that home composting, when properly conducted, can achieve excellent levels of stability, whereas industrial compost produced in the studied facilities can also present a high stability, although an important dispersion is found in these composts. The study also highlights the importance of respiration techniques to have a reliable characterization of compost quality, while the chemical characterization does not provide enough information to have a complete picture of a compost sample. Copyright © 2014 Elsevier Ltd. All rights reserved.

PULSED FOCUSED ULTRASOUND TREATMENT OF MUSCLE MITIGATES PARALYSIS-INDUCED BONE LOSS IN THE ADJACENT BONE: A STUDY IN A MOUSE MODEL

PubMed Central

Poliachik, Sandra L.; Khokhlova, Tatiana D.; Wang, Yak-Nam; Simon, Julianna C.; Bailey, Michael R.

2015-01-01

Bone loss can result from bed rest, space flight, spinal cord injury or age-related hormonal changes. Current bone loss mitigation techniques include pharmaceutical interventions, exercise, pulsed ultrasound targeted to bone and whole body vibration. In this study, we attempted to mitigate paralysis-induced bone loss by applying focused ultrasound to the midbelly of a paralyzed muscle. We employed a mouse model of disuse that uses onabotulinumtoxinA-induced paralysis, which causes rapid bone loss in 5 d. A focused 2 MHz transducer applied pulsed exposures with pulse repetition frequency mimicking that of motor neuron firing during walking (80 Hz), standing (20 Hz), or the standard pulsed ultrasound frequency used in fracture healing (1 kHz). Exposures were applied daily to calf muscle for 4 consecutive d. Trabecular bone changes were characterized using micro-computed tomography. Our results indicated that application of certain focused pulsed ultrasound parameters was able to mitigate some of the paralysis-induced bone loss. PMID:24857416

Multiple focused EMAT designs for improved surface breaking defect characterization

NASA Astrophysics Data System (ADS)

Thring, C. B.; Fan, Y.; Edwards, R. S.

2017-02-01

Ultrasonic Rayleigh waves can be employed for the detection of surface breaking defects such as rolling contact fatigue and stress corrosion cracking. Electromagnetic Acoustic Transducers (EMATs) are well suited to this technique as they can directly generate Rayleigh waves within the sample without the requirement for wedges, and they are robust and inexpensive compared to laser ultrasonics. Three different EMAT coil types have been developed, and these are compared to assess their ability to detect and characterize small (down to 0.5 mm depth, 1 mm diameter) surface breaking defects in aluminium. These designs are: a pair of linear meander coils used in a pseudo-pulse-echo mode, a pair of focused meander coils also used in pseudo-pulse-echo mode, and a pair of focused racetrack coils used in pitch-catch mode. The linear meander coils are able to detect most of the defects tested, but have a much lower signal to noise ratio and give limited sizing information. The focused meander coils and the focused racetrack coils can detect all defects tested, but have the advantage that they can also characterize the defect sizes on the sample surface, and have a stronger sensitivity at their focal point. Measurements using all three EMAT designs are presented and compared for high resolution imaging of surface-breaking defects.

Characterizing Students' Attempts to Explain Observations from Practical Work: Intermediate Phases of Understanding

NASA Astrophysics Data System (ADS)

Mestad, Idar; Kolstø, Stein Dankert

2017-10-01

This study aims to characterize a group of students' preliminary oral explanations of a scientific phenomenon produced as part of their learning process. The students were encouraged to use their own wordings to test out their own interpretation of observations when conducting practical activities. They presented their explanations orally in the whole class after having discussed and written down an explanation in a small group. The data consists of transcribed video recordings of the presented explanations, observation notes, and interviews. A genre perspective was used to characterize the students' explanations together with analysis of the students use of scientific terms, gestures, and the language markers "sort of" and "like." Based on the analysis we argue to separate between event-focused explanations, where the students describe how objects move, and object-focused explanations, where the students describe object properties and interactions. The first type uses observable events and few scientific terms, while the latter contains object properties and tentative use of scientific terms. Both types are accompanied by an extensive use of language markers and gestures. A third category, term-focused explanations, is used when the students only provide superficial explanations by expressing scientific terms. Here, the students' use of language markers and gestures are low. The analyses shows how students' explanations can be understood as tentative attempts to build on their current understanding and observations while trying to reach out for a deeper and scientific way of identifying observations and building explanations and new ways of talking.

Nondestructive Evaluation Methods for Characterization of Corrosion: State of the Art Review

DTIC Science & Technology

1988-12-01

form molecules of hydrogen gas damage is characterized by surface discolora- and leave the surface. Under some circum- tion and deep gouges or pits...large electromagnet and low operating granular corrosion without stress-related crack- frequencies resulted in deep penetration of ing can produce a...focus, and then the spray al. (11) showed that thermography was able to and the focus were moved together down the detect 3-mm deep , 50-mm diameter

Synesthetic experiences enhance unconscious learning.

PubMed

Rothen, Nicolas; Scott, Ryan B; Mealor, Andy D; Coolbear, Daniel J; Burckhardt, Vera; Ward, Jamie

2013-01-01

Synesthesia  is characterized  by consistent extra perceptual experiences in response to normal sensory input. Recent studies provide evidence for a specific profile of enhanced memory performance in synesthesia, but focus exclusively on explicit memory paradigms for which the learned content is consciously accessible. In this study, for the first time, we demonstrate with an implicit memory paradigm that synesthetic experiences also enhance memory performance relating to unconscious knowledge.

Research on Foreign Language Teaching and Learning in Turkey (2005-2009)

ERIC Educational Resources Information Center

Alptekin, Cem; Tatar, Sibel

2011-01-01

This is an overview of research on applied linguistics and foreign language education in Turkey, surveying nearly 130 studies from the period 2005-2009. Following a brief presentation of the history and current sociopolitical situation of foreign language education in Turkey, the article focuses on research that characterizes the most common…

Differential Transitions between Cocaine Use and Abstinence for Men and Women

ERIC Educational Resources Information Center

Gallop, Robert J.; Crits-Christoph, Paul; Ten Have, Thomas R.; Barber, Jacques P.; Frank, Arlene; Griffin, Margaret L.; Thase, Michael E.

2007-01-01

The longitudinal course of cocaine dependence is characterized by alternating periods of abstinence and relapse. Although gender has emerged as an important predictor of relapse, previous studies have examined mean differences in use by gender. Focusing strictly on differences in averages between men and women does not address potential gender…

Understanding the Phenotypic Structure of Adult Retrospective ADHD Symptoms during Childhood in the United States

ERIC Educational Resources Information Center

Ranby, Krista W.; Boynton, Marcella H.; Kollins, Scott H.; McClernon, F. Joseph; Yang, Chongming; Fuemmeler, Bernard F.

2012-01-01

Attention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous disorder, and the phenotypic structure comprising inattentive and hyperactive-impulsive type symptoms has been the focus of a growing body of recent research. Methodological studies are needed to better characterize phenotypes to advance research as well as clinical…

Effects-based Monitoring with Caged Fathead Minnows: An Exposure Gradient Case Study in the Duluth-Superior Harbor, USA

EPA Science Inventory

Within the Great Lakes there is an increased focus on contaminants of emerging concern (CECs) and consideration of potential effects of chemical mixtures. To further characterize the utility of caged fathead minnows (Pimephales promelas) for effects-based monitoring of CECs, we c...

Effects-based Monitoring with Caged Fathead Minnows: An Exposure Gradient Case Study in the Duluth-Superior Harbor, USA (SETAC meeting)

EPA Science Inventory

Within the Great Lakes there is an increased focus on contaminants of emerging concern (CECs) and consideration of potential effects of chemical mixtures. To further characterize the utility of caged fathead minnows (Pimephales promelas) for effects-based monitoring of CECs, we c...

Characterizing Instructor Gestures in a Lecture in a Proof-Based Mathematics Class

ERIC Educational Resources Information Center

Weinberg, Aaron; Fukawa-Connelly, Tim; Wiesner, Emilie

2015-01-01

Researchers have increasingly focused on how gestures in mathematics aid in thinking and communication. This paper builds on Arzarello's (2006) idea of a "semiotic bundle" and several frameworks for describing individual gestures and applies these ideas to a case study of an instructor's gestures in an undergraduate abstract algebra…

Children with Comorbid Speech Sound Disorder and Specific Language Impairment Are at Increased Risk for Attention-Deficit/Hyperactivity Disorder

ERIC Educational Resources Information Center

McGrath, Lauren M.; Hutaff-Lee, Christa; Scott, Ashley; Boada, Richard; Shriberg, Lawrence D.; Pennington, Bruce F.

2008-01-01

This study focuses on the comorbidity between attention-deficit/hyperactivity disorder (ADHD) symptoms and speech sound disorder (SSD). SSD is a developmental disorder characterized by speech production errors that impact intelligibility. Previous research addressing this comorbidity has typically used heterogeneous groups of speech-language…

About the Nutritional Science Research Group | Division of Cancer Prevention

Cancer.gov

The Nutritional Science Research Group (NSRG) promotes and supports studies establishing a comprehensive understanding of the precise role of diet and food components in modulating cancer risk and tumor cell behavior. This focus includes approaches to characterize molecular targets and variability in individual responses to nutrients and dietary patterns. |

Responding to Crises in Transnational Education: New Challenges for Higher Education

ERIC Educational Resources Information Center

Feast, Vicki; Bretag, Tracey

2005-01-01

This paper is based on a case study of an Australian university involved in the delivery of transnational programs in an educational environment that has been increasingly characterized by commercial considerations. The researchers conducted focus group interviews with both general and academic staff to ascertain the personal, academic and…

Multifractal Characterization of Geologic Noise for Improved UXO Detection and Discrimination

DTIC Science & Technology

2008-03-01

12 Recovery of the Universal Multifractal Parameters ...dipole-model to each magnetic anomaly and compares the extracted model parameters with a library of UXO items. They found that remnant magnetization...the survey parameters , and the geologic environment. In this pilot study we have focused on the multifractal representation of natural variations

How Do Teachers Coordinate Their Work? A Framing Approach

ERIC Educational Resources Information Center

Dumay, Xavier

2014-01-01

Since the 1970s, schools have been characterized as loosely coupled systems, meaning that the teachers' work is weakly coordinated at the local level. Nonetheless, few studies have focused on the local variations of coordination modes, their sources and their nature. In this article, the process of local coordination of the teachers' work is…

Processing and Characterization of Cellulose Nanocrystals/Polylactic Acid Nanocomposite Films

Treesearch

Erin Sullivan; Robert Moon; Kyriaki Kalaitzidou

2015-01-01

The focus of this study is to examine the effect of cellulose nanocrystals (CNC) on the properties of polylactic acid (PLA) films. The films are fabricated via melt compounding and melt fiber spinning followed by compression molding. Film fracture morphology, thermal properties, crystallization behavior, thermo-mechanical behavior, and mechanical behavior were...

Perceived Instability in Emerging Adulthood: The Protective Role of Identity Capital

ERIC Educational Resources Information Center

Luyckx, Koen; De Witte, Hans; Goossens, Luc

2011-01-01

Developmental instability characterizes the late teens and twenties in today's late-modern society. The present study (a) focused on the link between instability and both general (i.e., self-esteem and depressive symptoms) and work-related outcomes (i.e., work engagement and burnout) and (b) investigated the possible moderating role of identity…

Bi-Static Deep Electromagnetic Soundings for Martian Subsurface Characterization: Experimental Validation in the Egyptian Western Desert

NASA Astrophysics Data System (ADS)

Ciarletti, V.; Le Gall, A.; Berthelier, J. J.; Corbel, Ch.; Dolon, F.; Ney, R.; Reineix, A.; Guiffaud, Ch.; Clifford, S.; Heggy, E.

2007-03-01

A bi-static version of the HF GPR TAPIR developed for martian deep soundings has been operated in the Egyptian Western Desert. The study presented focuses on the retrieval of the direction of arrival of the observed echoes on both simulated and measured d

Proceedings from the 2011 American Association of Oral and Maxillofacial Surgeons Research Summit

DTIC Science & Technology

2012-01-01

technetium-99m sulfur colloid) that is then detect- able on nuclear imaging. The tracer enters the inter- stitial space, flows to lymphatic capillaries, and be... cochlear function. The focus of future studies is to further characterize the TGF- signaling pathway and its effects on bone extracellular matrix quality

From Peones to Politicos: Ethnic Relations in a South Texas Town, 1900 to 1975.

ERIC Educational Resources Information Center

Foley, Douglas E.; And Others

Focusing on how "North Town" Anglos and Mexicanos have related to each other and have dealt with the proplems of economic inequality and racial discrimination, the study characterized the ethnic relations into three major historical periods: the "Rancho" Era (1900-30), the "Colonia" Era (1930-60), and the Contemporary…

Inhibitory Control in Anxious and Healthy Adolescents Is Modulated by Incentive and Incidental Affective Stimuli

ERIC Educational Resources Information Center

Hardin, Michael G.; Mandell, Darcy; Mueller, Sven C.; Dahl, Ronald E.; Pine, Daniel S.; Ernst, Monique

2009-01-01

Background: Anxiety disorders are characterized by elevated, sustained responses to threat, that manifest as threat attention biases. Recent evidence also suggests exaggerated responses to incentives. How these characteristics influence cognitive control is under debate and is the focus of the present study. Methods: Twenty-five healthy…

Variation in MHC class II B genes in marbled murrelets: implications for delineating conservation units

Treesearch

C. Vásquez-Carrillo; V. Friesen; L. Hall; M.Z. Peery

2013-01-01

Conserving genetic variation is critical for maintaining the evolutionary potential and viability of a species. Genetic studies seeking to delineate conservation units, however, typically focus on characterizing neutral genetic variation and may not identify populations harboring local adaptations. Here, variation at two major histocompatibility complex (MHC) class II...

Expression of Emotion Through Family Grouping Schemata, Distance, and Interpersonal Focus

ERIC Educational Resources Information Center

Gerber, Gwen L.; Kaswan, Jaques

1971-01-01

A family doll placement technique was used to study separateness and connectedness within the family as this varies over positive and negative emotional themes. As hypothesized, positive emotional themes were represented by closer doll placements than negative themes. Emotions were also characterized by using certain kinds of groupings and…

Characterization of an EPG waveform library for pre-reproductive adult Lygus lineolaris and L. hesperus feeding on cotton squares

USDA-ARS?s Scientific Manuscript database

Tarnished plant bugs, Lygus lineolaris and L. hesperus, are among the most important pests affecting production of cotton in the mid-southern and western United States, respectively. Previous studies have focused on feeding damage to cotton reproductive structures from destructive enzymatic saliva. ...

Time-of-Day Effects in Arousal: Disrupted Diurnal Cortisol Profiles in Children with ADHD

ERIC Educational Resources Information Center

Imeraj, Lindita; Antrop, Inge; Roeyers, Herbert; Swanson, James; Deschepper, Ellen; Bal, Sarah; Deboutte, Dirk

2012-01-01

Background: Fluctuations in attention-deficit hyperactivity disorder (ADHD) symptoms related to regulatory deficits in arousal states are themselves characterized by circadian rhythms. Although cortisol is an important circadian arousal-related marker, studies focusing on across-the-day cortisol variations in ADHD are scarce. There is no study…

On the Strong Direct Summand Conjecture

ERIC Educational Resources Information Center

McCullough, Jason

2009-01-01

In this thesis, our aim is the study the Vanishing of Maps of Tor Conjecture of Hochster and Huneke. We mainly focus on an equivalent characterization called the Strong Direct Summand Conjecture, due to N. Ranganathan. Our results are separated into three chapters. In Chapter 3, we prove special cases of the Strong Direct Summand Conjecture in…

Introduction to special section: China shale gas and shale oil plays

USGS Publications Warehouse

Jiang, Shu; Zeng, Hongliu; Zhang, Jinchuan; Fishman, Neil; Bai, Baojun; Xiao, Xianming; Zhang, Tongwei; Ellis, Geoffrey S.; Li, Xinjing; Richards-McClung, Bryony; Cai, Dongsheng; Ma, Yongsheng

2015-01-01

Even though China shale gas and shale oil exploration is still in an early stage, limited data are already available. We are pleased to have selected eight high-quality papers from fifteen submitted manuscripts for this timely section on the topic of China shale gas and shale oil plays. These selected papers discuss various subject areas including regional geology, resource potentials, integrated and multidisciplinary characterization of China shale reservoirs (geology, geophysics, geochemistry, and petrophysics) China shale property measurement using new techniques, case studies for marine, lacustrine, and transitional shale deposits in China, and hydraulic fracturing. One paper summarizes the regional geology and different tectonic and depositional settings of the major prospective shale oil and gas plays in China. Four papers concentrate on the geology, geochemistry, reservoir characterization, lithologic heterogeneity, and sweet spot identification in the Silurian Longmaxi marine shale in the Sichuan Basin in southwest China, which is currently the primary focus of shale gas exploration in China. One paper discusses the Ordovician Salgan Shale in the Tarim Basin in northwest China, and two papers focus on the reservoir characterization and hydraulic fracturing of Triassic lacustrine shale in the Ordos Basin in northern China. Each paper discusses a specific area.

The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.

PubMed

Chenoweth, Alicia M; Trist, Halina M; Tan, Peck-Szee; Wines, Bruce D; Hogarth, P Mark

2015-11-01

Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characterization of macaque Fc receptors so far has focused on the low-affinity Fc receptors, particularly FcγRIIIa. From these studies, it is clear that there are distinct differences between the human and macaque low-affinity receptors and their interaction with human IgG. Relatively little work has been performed on the high-affinity IgG receptor, FcγRI, especially in NHPs. This review will focus on what is currently known of how FcγRI interacts with IgG, from mutation studies and recent crystallographic studies of human FcγRI, and how amino acid sequence differences in the macaque FcγRI may affect this interaction. Additionally, this review will look at the functional consequences of differences in the amino acid sequences between humans and macaques. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A cMUT probe for ultrasound-guided focused ultrasound targeted therapy.

PubMed

Gross, Dominique; Coutier, Caroline; Legros, Mathieu; Bouakaz, Ayache; Certon, Dominique

2015-06-01

Ultrasound-mediated targeted therapy represents a promising strategy in the arsenal of modern therapy. Capacitive micromachined ultrasonic transducer (cMUT) technology could overcome some difficulties encountered by traditional piezoelectric transducers. In this study, we report on the design, fabrication, and characterization of an ultrasound-guided focused ultrasound (USgFUS) cMUT probe dedicated to preclinical evaluation of targeted therapy (hyperthermia, thermosensitive liposomes activation, and sonoporation) at low frequency (1 MHz) with simultaneous ultrasonic imaging and guidance (15 to 20 MHz). The probe embeds two types of cMUT arrays to perform the modalities of targeted therapy and imaging respectively. The wafer-bonding process flow employed for the manufacturing of the cMUTs is reported. One of its main features is the possibility of implementing two different gap heights on the same wafer. All the design and characterization steps of the devices are described and discussed, starting from the array design up to the first in vitro measurements: optical (microscopy) and electrical (impedance) measurements, arrays' electroacoustic responses, focused pressure field mapping (maximum peak-to-peak pressure = 2.5 MPa), and the first B-scan image of a wire-target phantom.

Characterization of electrical appliances in transient state

NASA Astrophysics Data System (ADS)

Wójcik, Augustyn; Winiecki, Wiesław

2017-08-01

The article contains the study about electrical appliance characterization on the basis of power grid signals. To represent devices, parameters of current and voltage signals recorded during transient states are used. In this paper only transients occurring as a result of switching on devices are considered. The way of data acquisition performed in specialized measurement setup developed for electricity load monitoring is described. The paper presents the method of transients detection and the method of appliance parameters calculation. Using the set of acquired measurement data and appropriate software the set of parameters for several household appliances operating in different operating conditions was processed. Usefulness of appliances characterization in Non-Intrusive Appliance Load Monitoring System (NIALMS) with the use of proposed method is discussed focusing on obtained results.

Publication trend, resource utilization, and impact of the US National Cancer Database

PubMed Central

Su, Chang; Peng, Cuiying; Agbodza, Ena; Bai, Harrison X.; Huang, Yuqian; Karakousis, Giorgos; Zhang, Paul J.; Zhang, Zishu

2018-01-01

Abstract Background: The utilization and impact of the studies published using the National Cancer Database (NCDB) is currently unclear. In this study, we aim to characterize the published studies, and identify relatively unexplored areas for future investigations. Methods: A literature search was performed using PubMed in January 2017 to identify all papers published using NCDB data. Characteristics of the publications were extracted. Citation frequencies were obtained through the Web of Science. Results: Three hundred 2 articles written by 230 first authors met the inclusion criteria. The number of publications grew exponentially since 2013, with 108 articles published in 2016. Articles were published in 86 journals. The majority of the published papers focused on digestive system cancer, while bone and joints, eye and orbit, myeloma, mesothelioma, and Kaposi Sarcoma were never studied. Thirteen institutions in the United States were associated with more than 5 publications. The papers have been cited for a total of 9858 times since the publication of the first paper in 1992. Frequently appearing keywords congregated into 3 clusters: “demographics,” “treatments and survival,” and “statistical analysis method.” Even though the main focuses of the articles captured a extremely wide range, they can be classified into 2 main categories: survival analysis and characterization. Other focuses include database(s) analysis and/or comparison, and hospital reporting. Conclusion: The surging interest in the use of NCDB is accompanied by unequal utilization of resources by individuals and institutions. Certain areas were relatively understudied and should be further explored. PMID:29489679

Characterization and stability studies of bioactive compounds and food matrices as evidence in support of health claims.

PubMed

González-Ferrero, Carolina; Sáiz-Abajo, María-José

2015-07-01

The characterization and stability evaluation of food and food constituents (chemical active ingredient/microorganism) for which nutrition or health claims want to be requested are essential for the success of an application to EFSA. This work reviews the requirements that must be fulfilled for a full characterization of the active substance, comprising origin, elaboration, or extraction method, and chemical/microbiological composition, using validated analytical methods. The review focuses not only on establishing the specifications of the final active ingredient or food but also on ensuring homogeneity between batches. In addition, the article discusses the methodologies and conditions of the stability studies that need to be performed on food and food constituents to verify that the relevant compounds--chemical and microbiological active ingredients--will get to the consumer in the intended state and concentration to accomplish the claimed health effect over shelf life.

Nutrient Characterization of Rainwater, Soil and Groundwater from Two Different Watersheds, Lake Taihu, China

NASA Astrophysics Data System (ADS)

Thaw, M.; Gao, F.; Yu, Z.; Acharya, K.

2012-12-01

Over the past two decades, an increase of nutrients to Lake Taihu, China has resulted in hyper-eutrophication and the production of severe cyanobacterial blooms. While many past studies have focused on how surface water transports nutrients to the lake, this study seeks to characterize the concentration of nutrients in different media, including rainwater, soil and groundwater from two different watersheds. These two watersheds varied in overall land use, and agricultural sites within each watershed varied by crop type and growing method. Samples were collected from the Meilin watershed, a mix of forest and agricultural land and the Zhangjiagang watershed, which consisted of industrial, urban and agricultural lands. Samples included soils, groundwater and rain water. Soils from each site were characterized by aggregate size class and analyzed for total nitrogen and total phosphorus. Rainwater and groundwater samples were analyzed for total nitrogen and total phosphorus.

Harnessing glycomics technologies: integrating structure with function for glycan characterization

PubMed Central

Robinson, Luke N.; Artpradit, Charlermchai; Raman, Rahul; Shriver, Zachary H.; Ruchirawat, Mathuros; Sasisekharan, Ram

2013-01-01

Glycans, or complex carbohydrates, are a ubiquitous class of biological molecules which impinge on a variety of physiological processes ranging from signal transduction to tissue development and microbial pathogenesis. In comparison to DNA and proteins, glycans present unique challenges to the study of their structure and function owing to their complex and heterogeneous structures and the dominant role played by multivalency in their sequence-specific biological interactions. Arising from these challenges, there is a need to integrate information from multiple complementary methods to decode structure-function relationships. Focusing on acidic glycans, we describe here key glycomics technologies for characterizing their structural attributes, including linkage, modifications, and topology, as well as for elucidating their role in biological processes. Two cases studies, one involving sialylated branched glycans and the other sulfated glycosaminoglycans, are used to highlight how integration of orthogonal information from diverse datasets enables rapid convergence of glycan characterization for development of robust structure-function relationships. PMID:22522536

Gypsy Field project in reservoir characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castagna, John P.; Jr., O'Meara, Daniel J.

The overall objective of this project was to use extensive Gypsy Field Laboratory and data as a focus for developing and testing reservoir characterization methods that are targeted at improved recovery of conventional oil. This report describes progress since project report DOE/BC/14970-7 and covers the period June 1997-September 1998 and represents one year of funding originally allocated for the year 1996. During the course of the work previously performed, high resolution geophysical and outcrop data revealed the importance of fractures at the Gypsy site. In addition, personnel changes and alternative funding (OCAST and oil company support of various kinds) allowedmore » the authors to leverage DOE contributions and focus more on geophysical characterization.« less

Synthesis, Characterization, and Handling of Eu(II)-Containing Complexes for Molecular Imaging Applications

NASA Astrophysics Data System (ADS)

Basal, Lina A.; Allen, Matthew J.

2018-03-01

Considerable research effort has focused on the in vivo use of responsive imaging probes that change imaging properties upon reacting with oxygen because hypoxia is relevant to diagnosing, treating, and monitoring diseases. One promising class of compounds for oxygen-responsive imaging is Eu(II)-containing complexes because the Eu(II/III) redox couple enables imaging with multiple modalities including magnetic resonance and photoacoustic imaging. The use of Eu(II) requires care in handling to avoid unintended oxidation during synthesis and characterization. This review describes recent advances in the field of imaging agents based on discrete Eu(II)-containing complexes with specific focus on the synthesis, characterization, and handling of aqueous Eu(II)-containing complexes.

In-situ characterization of nanoparticle beams focused with an aerodynamic lens by Laser-Induced Breakdown Detection

PubMed Central

Barreda, F.-A.; Nicolas, C.; Sirven, J.-B.; Ouf, F.-X.; Lacour, J.-L.; Robert, E.; Benkoula, S.; Yon, J.; Miron, C.; Sublemontier, O.

2015-01-01

The Laser-Induced Breakdown Detection technique (LIBD) was adapted to achieve fast in-situ characterization of nanoparticle beams focused under vacuum by an aerodynamic lens. The method employs a tightly focused, 21 μm, scanning laser microprobe which generates a local plasma induced by the laser interaction with a single particle. A counting mode optical detection allows the achievement of 2D mappings of the nanoparticle beams with a reduced analysis time thanks to the use of a high repetition rate infrared pulsed laser. As an example, the results obtained with Tryptophan nanoparticles are presented and the advantages of this method over existing ones are discussed. PMID:26498694

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larouche, Stephane; Caldwell, Joshua

Symposium KK focused on the design, fabrication, characterization of novel nanoscale optical resonators and alternative materials for sub-diffraction scale resonant particles. Contributions discussed all aspects of this field, and the organizers had more than 130 contributing participants to this session alone, spanning North America, Europe, Asia and Australia. Participants discussed cutting edge research results focused on the structure, physical and optical properties, and ultrafast dynamic response of nanoscale resonators such as plasmonic and dielectric nanoparticles. A strong focus on state-of-the-art characterization and fabrication approaches, as well as presentations on novel materials for sub-diffraction resonators took place. As expected, the sessionsmore » provided strong interdisciplinary interactions and lively debate among presenters and participants.« less

Characterization of the spectral phase of an intense laser at focus via ionization blueshift

DOE PAGES

Mittelberger, D. E.; Nakamura, K.; Lehe, R.; ...

2016-01-01

An in situ diagnostic for verifying the spectral phase of an intense laser pulse at focus is shown. This diagnostic relies on measuring the effect of optical compression on ionization-induced blueshifting of the laser spectrum. Experimental results from the Berkeley Lab Laser Accelerator, a laser source rigorously characterized by conventional techniques, are presented and compared with simulations to illustrate the utility of this technique. These simulations show distinguishable effects from second-, third-, and fourth-order spectral phase.

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for Department of Veterans Affairs. James J. Peters VA Medical Center, Bronx, NY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Stephen; Francfort, Jim

This report focuses on the Department of Veterans Affairs, James J. Peters VA Medical Center (VA - Bronx) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.

AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study for the National Park Service: Sleeping Bear Dunes National Lakeshore

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schey, Stephen; Francfort, Jim

This report focuses on the Sleeping Bear Dunes National Lakeshore (SLBE) fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of plug-in electric vehicles (PEVs) into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle (BEV) or plug-in hybrid electric vehicle (PHEV) (collectively plug-in electric vehicles, or PEVs) can fulfill the mission requirements.

The Industrial Revolution in the Twentieth Century, with a Focus on Japan and the East Asian Followers.

ERIC Educational Resources Information Center

Ericson, Steven J.

2000-01-01

Addresses the suitability of the term "revolution," the national versus transnational focus, and characterizations of the industrial revolution. Considers a late-development model of industrialization and its application to East Asia. Focuses on issues in Japanese industrialization, such as the role of the Japanese government, militarism…

Knowledge and understanding of dissolved solids in the Rio Grande–San Acacia, New Mexico, to Fort Quitman, Texas, and plan for future studies and monitoring

USGS Publications Warehouse

Moyer, Douglas; Anderholm, Scott K.; Hogan, James F.; Phillips, Fred M.; Hibbs, Barry J.; Witcher, James C.; Matherne, Anne Marie; Falk, Sarah E.

2013-01-01

-Focused Hydrogeology Studies at Inflow Sources: Map dissolved-solids concentrations in the Rio Grande and underlying alluvial aquifer; perform hydrogeologic characterization of subsurface areas containing unusually high concentrations of dissolved solids. -Modeling of Dissolved Solids: Develop models to simulate the transport and storage of dissolved solids in both surface-water and groundwater systems.

INL Fleet Vehicle Characterization Study for the U.S. Department of Navy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, Brion Dale; Francfort, James Edward; Smart, John Galloway

Battelle Energy Alliance, LLC, managing and operating contractor for the U.S. Department of Energy’s Idaho National Laboratory, is the lead laboratory for U.S. Department of Energy Advanced Vehicle Testing. Battelle Energy Alliance, LLC collected and evaluated data on federal fleet operations as part of the Advanced Vehicle Testing Activity’s Federal Fleet Vehicle Data Logging and Characterization Study. The Advanced Vehicle Testing Activity’s study seeks to collect and evaluate data to validate use of advanced plug-in electric vehicle (PEV) transportation. This report focuses on US Department of Navy's fleet to identify daily operational characteristics of select vehicles and report findings onmore » vehicle and mission characterizations to support the successful introduction of PEVs into the agency’s fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.« less

Exploitation of immunofluorescence for the quantification and characterization of small numbers of Pasteuria endospores.

PubMed

Costa, Sofia R; Kerry, Brian R; Bardgett, Richard D; Davies, Keith G

2006-12-01

The Pasteuria group of endospore-forming bacteria has been studied as a biocontrol agent of plant-parasitic nematodes. Techniques have been developed for its detection and quantification in soil samples, and these mainly focus on observations of endospore attachment to nematodes. Characterization of Pasteuria populations has recently been performed with DNA-based techniques, which usually require the extraction of large numbers of spores. We describe a simple immunological method for the quantification and characterization of Pasteuria populations. Bayesian statistics were used to determine an extraction efficiency of 43% and a threshold of detection of 210 endospores g(-1) sand. This provided a robust means of estimating numbers of endospores in small-volume samples from a natural system. Based on visual assessment of endospore fluorescence, a quantitative method was developed to characterize endospore populations, which were shown to vary according to their host.

X-ray Absorption Fine Structure (XAFS) Studies of Oxide Glasses—A 45-Year Overview

PubMed Central

Zanotto, Edgar Dutra

2018-01-01

X-ray Absorption Fine Structure (XAFS) spectroscopy has been widely used to characterize the short-range order of glassy materials since the theoretical basis was established 45 years ago. Soon after the technique became accessible, mainly due to the existence of Synchrotron laboratories, a wide range of glassy materials was characterized. Silicate glasses have been the most studied because they are easy to prepare, they have commercial value and are similar to natural glasses, but borate, germanate, phosphate, tellurite and other less frequent oxide glasses have also been studied. In this manuscript, we review reported advances in the structural characterization of oxide-based glasses using this technique. A focus is on structural characterization of transition metal ions, especially Ti, Fe, and Ni, and their role in different properties of synthetic oxide-based glasses, as well as their important function in the formation of natural glasses and magmas, and in nucleation and crystallization. We also give some examples of XAFS applications for structural characterization of glasses submitted to high pressure, glasses used to store radioactive waste and medieval glasses. This updated, comprehensive review will likely serve as a useful guide to clarify the details of the short-range structure of oxide glasses. PMID:29382102

The Heart and Soul of the Class. Report Series 2.6.

ERIC Educational Resources Information Center

Marhafer, David

One of a series of six portraits of high school literature classrooms, this paper gives a detailed, evocative characterization of how one "master teacher" introduced, undertook, and guided the study of literature, focusing in particular on how the teacher interacted with students in the context of discussion of a literary work in class.…

Evaluating Students' Abilities to Construct Mathematical Models from Data Using Latent Class Analysis

ERIC Educational Resources Information Center

Brandriet, Alexandra; Rupp, Charlie A.; Lazenby, Katherine; Becker, Nicole M.

2018-01-01

Analyzing and interpreting data is an important science practice that contributes toward the construction of models from data; yet, there is evidence that students may struggle with making meaning of data. The study reported here focused on characterizing students' approaches to analyzing rate and concentration data in the context of method of…

What Makes Reform Work?--School-Based Conditions as Predictors of Teachers' Changing Practice after a National Curriculum Reform

ERIC Educational Resources Information Center

Ramberg, Magnus R.

2014-01-01

Educational change initiatives, whether they involve the implementation of new policies or curriculum reforms, often fail to reach the level of teachers' classroom practices. In the search for explanations, numerous studies have either characterized teachers as resistant to change or focused on how schools' workplace conditions have failed to…

Genetic diversity and populations structure in pitch pine (Pinus rigida Mill.)

Treesearch

Raymond P. Guries; F. Thomas Ledig

1982-01-01

Electrophoretic studies of protein polymorphisms in plants have focused upon herbaceous species, primarily inbreeding annuals, in efforts to characterize the levels and patterns of genic variation within and between populations (Clegg and Allard, 1972; Gottlieb, 1973, 1975; Levin, 1975, 1978; Levy and Levin, 1975; Schaal, 1975; Roose and Gottlieb, 1976; Brown et al.,...

The Professional Learning Community in Special Education Schools: The Principal's Role

ERIC Educational Resources Information Center

Schechter, Chen; Feldman, Niv

2013-01-01

The concept of a professional learning community is characterized by the networks of learning processes which exist among its members, where teachers continuously deliberate with one another on how to solve problems that relate to teaching and learning. Interestingly, whereas a growing number of studies have focused on how to promote collective…

Women in Higher Education: A Biographical Inquiry.

ERIC Educational Resources Information Center

Graham, Patricia Albjerg

The history of higher education in the U. S. traditionally has been characterized by the same kinds of studies as most other American history: ones that focus on the experiences or concerns of the authors. What such history ignores is the group that for most of this century comprised about 40 percent or more of the undergraduate student body and…

The Effect of Arousal and Focused Attention on Warm-Up Decrement.

ERIC Educational Resources Information Center

Anshel, Mark H.; Wrisberg, Craig A.

The resumption of skilled performance following a period of no practice is often characterized by motor activity of a lower quality than that demonstrated prior to the rest period. This phenomenon, termed warm-up decrement, is usually brief, lasting for only a few trials or minutes of postrest practice. This study attempted to determine the effect…

Sustained Attention at Age 5 Predicts Attention-Related Problems at Age 9

ERIC Educational Resources Information Center

Martin, Anne; Razza, Rachel A.; Brooks-Gunn, Jeanne

2012-01-01

This study tested whether two aspects of sustained attention (focused attention and lack of impulsivity) measured at child age 5 predicted attention problems reported by mothers and teachers at age 9. Because lack of impulsivity reflects the executive control network, and ADHD is commonly characterized as a deficit in executive function, it was…

Listening Behaviors in Japanese: "Aizuchi" and Head Nod Use by Native Speakers and Second Language Learners

ERIC Educational Resources Information Center

Hanzawa, Chiemi

2012-01-01

The purpose of the present study is to investigate similarities and differences in the listening behaviors of native speakers and learners of Japanese, focusing on the production of "aizuchi" and head nods. The term "aizuchi" is often interchangeably used with the word backchannel, and these are characterized as the…

Family Relationships in Realistic Young Adult Fiction, 1987 to 1991.

ERIC Educational Resources Information Center

Sampson, Cathie

The purpose of this study was to determine how parents and family relationships are characterized in realistic young adult fiction. A random sample of 20 realistic young adult novels was selected from the American Library Association's Best Lists for the years 1987-1991. A content analysis of the novels focused on the following: (1) whether…

Small High Schools on a Larger Scale: The Impact of School Conversions in Chicago

ERIC Educational Resources Information Center

Kahne, Joseph E.; Sporte, Susan E.; de la Torre, Marisa; Easton, John Q.

2008-01-01

This study examines 4 years of small school reform in Chicago, focusing on schools formed by converting large traditional high schools into small autonomous ones. Analyzing systemwide survey and outcome data, the authors assess the assumptions embedded in the reform's theory of change. They find that these schools are characterized by more…

"You Kiss by the Book": Shakespeare's "Romeo and Juliet." [Lesson Plan].

ERIC Educational Resources Information Center

2000

This lesson plan complements study of plot and characterization in "Romeo and Juliet" by focusing on Shakespeare's use of lyric forms and conventions to spotlight moments in the drama and thereby heightens the impact of the action on the stage. Students look first at the sonnet in which Romeo and Juliet meet, analyzing the imagery to…

The Role of Blogs and Web Resources in Students' Autonomous Learning Awareness

ERIC Educational Resources Information Center

Ballén, Diana

2014-01-01

This article focuses on the way in which technology-based activities may shape and characterize students' awareness of their own learning processes and their understanding of autonomy. The study was carried out at a public university in Colombia. Data collection was done through the implementation of class observations, a survey, and some focus…

Making Differences and Reflecting on Diversities: Embodied Nationality among Preschool Children

ERIC Educational Resources Information Center

Lappalainen, Sirpa

2009-01-01

This paper focuses on embodied practices in processes of nationalization among preschool children at the age of 6. It analyses how children define themselves and others, how they characterize and frame Finnishness through embodiment. The analysis is based on an ethnographic study in two preschool classes. It is argued that nationality works in a…

Using Size-Frequency Distributions to Analyze Fire Regimes in Florida

Treesearch

Thomas P. Holmes; Jeffrey P. Prestemon; John M. Pye; David T. Butry; D. Evan Mercer; Karen L. Abt

2004-01-01

Wildfire regimes in natural forest ecosystems have been characterized with power­law distributions. In this paper, we evaluated whether wildfire regimes in a human-dominated landscape were also consistent with power­law distributions. Our case study focused on wildfires in Florida, a state with rapid population growth and consequent rapid alteration of forest...

The Experience of Staging Nijinsky's "L'Apres-Midi d'un Faune" in a Higher Education Dance Program

ERIC Educational Resources Information Center

Curran, Tina

2010-01-01

This study documented the experiences of staging Vaslav Nijinsky's "L'Apres-midi d'un Faune" in a higher education dance program. The ballet was staged from Labanotation. Research questions focused on teaching and learning pedagogy, characterization of the process over time, experiences of the participants and teaching approaches. The project…

Characterizing User Behaviours and Products in an Online Educational Community: A Comparison between Novices and Elders

ERIC Educational Resources Information Center

Yuan, Min; Recker, Mimi

2014-01-01

This study focuses on two user types in an online educational community--novices and elders--and explores the characteristics of their behaviours and contributed products by analyzing usage logs. Results show that novices and elders have different behavioural trajectories. In addition, the products created by elders attract more views.

The role of valence focus and appraisal overlap in emotion differentiation.

PubMed

Erbas, Yasemin; Ceulemans, Eva; Koval, Peter; Kuppens, Peter

2015-06-01

Emotion differentiation refers to the level of specificity with which people distinguish between their emotional states and is considered to play an important role for psychological well-being. Yet, not much is known about what characterizes people high or low in emotion differentiation and what underlies these differences. In 2 studies involving experience sampling (Studies 1-2) and lab based (Study 2) methods, we investigated how emotion differentiation is related to individual differences in valence focus and the overlap in appraisal patterns between emotions. In line with expectations, results showed that high levels of both positive and negative emotion differentiation are related to lower levels of valence focus and lower levels of appraisal overlap between emotions. These findings suggest that individuals who are low in emotion differentiation mainly emphasize the valence aspect of emotions while individuals who are high in emotion differentiation make stronger distinctions between emotions in terms of their underlying appraisal profiles. (c) 2015 APA, all rights reserved).

Characterization of Light Lesion Paradigms and Optical Coherence Tomography as Tools to Study Adult Retina Regeneration in Zebrafish

PubMed Central

Weber, Anke; Hochmann, Sarah; Cimalla, Peter; Gärtner, Maria; Kuscha, Veronika; Hans, Stefan; Geffarth, Michaela; Kaslin, Jan; Koch, Edmund; Brand, Michael

2013-01-01

Light-induced lesions are a powerful tool to study the amazing ability of photoreceptors to regenerate in the adult zebrafish retina. However, the specificity of the lesion towards photoreceptors or regional differences within the retina are still incompletely understood. We therefore characterized the process of degeneration and regeneration in an established paradigm, using intense white light from a fluorescence lamp on swimming fish (diffuse light lesion). We also designed a new light lesion paradigm where light is focused through a microscope onto the retina of an immobilized fish (focused light lesion). Focused light lesion has the advantage of creating a locally restricted area of damage, with the additional benefit of an untreated control eye in the same animal. In both paradigms, cell death is observed as an immediate early response, and proliferation is initiated around 2 days post lesion (dpl), peaking at 3 dpl. We furthermore find that two photoreceptor subtypes (UV and blue sensitive cones) are more susceptible towards intense white light than red/green double cones and rods. We also observed specific differences within light lesioned areas with respect to the process of photoreceptor degeneration: UV cone debris is removed later than any other type of photoreceptor in light lesions. Unspecific damage to retinal neurons occurs at the center of a focused light lesion territory, but not in the diffuse light lesion areas. We simulated the fish eye optical properties using software simulation, and show that the optical properties may explain the light lesion patterns that we observe. Furthermore, as a new tool to study retinal degeneration and regeneration in individual fish in vivo, we use spectral domain optical coherence tomography. Collectively, the light lesion and imaging assays described here represent powerful tools for studying degeneration and regeneration processes in the adult zebrafish retina. PMID:24303018

Reflective Functioning in Parents of School-Aged Children

PubMed Central

Borelli, Jessica L.; St. John, H. Kate; Cho, Evelyn; Suchman, Nancy E.

2016-01-01

Parental reflective functioning (RF) has garnered tremendous support as a predictor of secure attachment in infancy, though little work has examined RF among parents of older children. In this study, we used a high-risk community sample of parent–child dyads (N = 117) to explore whether parental RF comprises self- and child-focused factors, whether parental RF is associated with parent and child attachment security, and whether parental RF mediates the association between parent and child attachment security. Results suggested that parental RF can be characterized as having both self- and child-focused components, and that child-focused parental RF is associated with child but not parent attachment security. Further, child-focused parental RF indirectly mediates the association between parent attachment avoidance and child attachment security. These findings extend previous work on parental RF to parents of school-age children and, in so doing, inform developmental models of attachment relationships in middle childhood. Discussion focuses on the importance of these findings in informing theory, prevention, clinical practice, and policy. PMID:26618938

Challenges in Physical Characterization of Dim Space Objects: What Can We Learn from NEOs

NASA Astrophysics Data System (ADS)

Reddy, V.; Sanchez, J.; Thirouin, A.; Rivera-Valentin, E.; Ryan, W.; Ryan, E.; Mokovitz, N.; Tegler, S.

2016-09-01

Physical characterization of dim space objects in cis-lunar space can be a challenging task. Of particular interest to both natural and artificial space object behavior scientists are the properties beyond orbital parameters that can uniquely identify them. These properties include rotational state, size, shape, density and composition. A wide range of observational and non-observational factors affect our ability to characterize dim objects in cis-lunar space. For example, phase angle (angle between Sun-Target-Observer), temperature, rotational variations, temperature, and particle size (for natural dim objects). Over the last two decades, space object behavior scientists studying natural dim objects have attempted to quantify and correct for a majority of these factors to enhance our situational awareness. These efforts have been primarily focused on developing laboratory spectral calibrations in a space-like environment. Calibrations developed correcting spectral observations of natural dim objects could be applied to characterizing artificial objects, as the underlying physics is the same. The paper will summarize our current understanding of these observational and non-observational factors and present a case study showcasing the state of the art in characterization of natural dim objects.

Characterizing structures on borehole images and logging data of the Nankai trough accretionary prism: new insights

NASA Astrophysics Data System (ADS)

Jurado, Maria Jose

2016-04-01

IODP has extensively used the D/V Chikyu to drill the Kumano portion of the Nankai Trough, including two well sites within the Kumano Basin. IODP Expeditions 338 and 348 drilled deep into the inner accretionary prism south of the Kii Peninsula collecting a suite of LWD data, including natural gamma ray, electrical resistivity logs and borehole images, suitable to characterize structures (fractures and faults) inside the accretionary prism. Structural interpretation and analysis of logging-while-drilling data in the deep inner prism revealed intense deformation of a generally homogenous lithology characterized by bedding that dips steeply (60-90°) to the NW, intersected by faults and fractures. Multiple phases of deformation are characterized. IODP Expedition borehole images and LWD data acquired in the last decade in previous and results of NantroSEIZE IODP Expeditions (314, 319) were also analyzed to investigate the internal geometries and structures of the Nankai Trough accretionary prism. This study focused mainly on the characterization of the different types of structures and their specific position within the accretionary prism structures. New structural constraints and methodologies as well as a new approach to the characterization of study of active structures inside the prism will be presented.

Characterization, monitoring, and sensor technology crosscutting program: Technology summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-06-01

The purpose of the Characterization, Monitoring, and Sensor Technology Crosscutting Program (CMST-CP) is to deliver appropriate characterization, monitoring, and sensor technology (CMST) to the Office of Waste Management (EM-30), the Office of Environmental Restoration (EM-40), and the Office of Facility Transition and Management (EM-60). The technology development must also be cost effective and appropriate to EM-30/40/60 needs. Furthermore, the required technologies must be delivered and implemented when needed. Accordingly, and to ensure that available DOE and other national resources are focused an the most pressing needs, management of the technology development is concentrated on the following Focus Areas: Contaminant Plumemore » Containment and Remediation (PFA); Landfill Stabilization (LSFA); High-Level Waste Tank Remediation (TFA); Mixed Waste Characterization, Treatment, and Disposal (MWFA); and Facility Deactivation, Decommissioning, and Material Disposition (FDDMDFA). Brief descriptions of CMST-CP projects funded in FY95 are presented.« less

The Joint Agency Commercial Imagery Evaluation (JACIE) Team: Overview and IKONOS Joint Characterization Approach

NASA Technical Reports Server (NTRS)

Zanoni, Vicki; Ryan, Robert; Pagnutti, Mary; Baldridge, Braxton; Roylance, Spencer; Snyder, Greg; Lee, George; Stanley, Tom

2002-01-01

An overview of the Joint Agency Commercial Imagery Evalation (JACIE) team is presented. JACIE, composed of the National Aeronautics and Space Administration (NASA), the National Imagery and Mapping Agency (NIMA), and the U.S. Geological Survey (USGS), was formed to leverage government agencies' capabilities for the characterization of commercial remote sensing data. Each JACIE agency purchases, or plans to purchase, commercial imagery to support its research and applications. It is critical that the data be assessed for its accuracy and utility. Through JACIE, NASA, NIMA, and USGS jointly characterized image products from Space Imaging's IKONOS satellite. Each JACIE agency performed an aspect of the characterization based on its expertise. NASA and its university partners performed a system characterization focusing on radiometric calibration, geopositional accuracy, and spatial resolution assessment; NIMA performed image interpretability and feature extraction evaluations; and USGS assessed geopositional accuracy of several IKONOS products. The JACIE team purchased IKONOS imagery of several study sites to perform the assessments and presented results at an industry-government workshop. Future plans for JACIE include the characterization of DigitalGlobe's QuickBird-2 image products.

Design, Fabrication, and Characterization of Metamaterials for Transformation Optics and Focusing Applications

DTIC Science & Technology

2014-02-11

of refraction in the region of the “lens”, successfully focusing surface plasmon polaritons (SPP). SUPERABSORBERS: The team used the Rigorous Coupled...PLASMONIC FOCUSING: The team constructed a device capable of splitting and focusing surface plasmon polaritons into different locations depending on the...surface plasmon polaritons , plasmonics 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18, NUMBER OF PAGES 19 19a. NAME

Reproduction in Leishmania: A focus on genetic exchange.

PubMed

Rougeron, V; De Meeûs, T; Bañuls, A-L

2017-06-01

One key process of the life cycle of pathogens is their mode of reproduction. Indeed, this fundamental biological process conditions the multiplication and the transmission of genes and thus the propagation of diseases in the environment. Reproductive strategies of protozoan parasites have been a subject of debate for many years, principally due to the difficulty in making direct observations of sexual reproduction (i.e. genetic recombination). Traditionally, these parasites were considered as characterized by a preeminent clonal structure. Nevertheless, with the development of elaborate culture experiments, population genetics and evolutionary and population genomics, several studies suggested that most of these pathogens were also characterized by constitutive genetic recombination events. In this opinion, we focused on Leishmania parasites, pathogens responsible of leishmaniases, a major public health issue. We first discuss the evolutionary advantages of a mixed mating reproductive strategy, then we review the evidence of genetic exchange, and finally we detail available tools to detect naturally occurring genetic recombination in Leishmania parasites and more generally in protozoan parasites. Copyright © 2016. Published by Elsevier B.V.

Fruit and Vegetable Quality Assessment via Dielectric Sensing

PubMed Central

El Khaled, Dalia; Novas, Nuria; Gazquez, Jose A.; Garcia, Rosa M.; Manzano-Agugliaro, Francisco

2015-01-01

The demand for improved food quality has been accompanied by a technological boost. This fact enhances the possibility of improving the quality of horticultural products, leading towards healthier consumption of fruits and vegetables. A better electrical characterization of the dielectric properties of fruits and vegetables is required for this purpose. Moreover, a focused study of dielectric spectroscopy and advanced dielectric sensing is a highly interesting topic. This review explains the dielectric property basics and classifies the dielectric spectroscopy measurement techniques. It comprehensively and chronologically covers the dielectric experiments explored for fruits and vegetables, along with their appropriate sensing instrumentation, analytical modelling methods and conclusions. An in-depth definition of dielectric spectroscopy and its usefulness in the electric characterization of food materials is presented, along with the various sensor techniques used for dielectric measurements. The collective data are tabulated in a summary of the dielectric findings in horticultural field investigations, which will facilitate more advanced and focused explorations in the future. PMID:26131680

Nanomaterials Work at NASA-Johnson Space Center

NASA Technical Reports Server (NTRS)

Arepalli, Sivaram

2005-01-01

Nanomaterials activities at NASA-Johnson Space Center focus on single wall carbon nanotube production, characterization and their applications for aerospace. Nanotubes are produced by arc and laser methods and the growth process is monitored by in-situ diagnostics using time resolved passive emission and laser induced fluorescence of the active species. Parametric study of both these processes are conducted to monitor the effect of production parameters including temperature, buffer gas, flow rate, pressure, laser fluence and arc current. Characterization of the nanotube material is performed using the NASA-JSC protocol developed by combining analytical techniques of SEM, TEM, UV-VIS-NIR absorption, Raman, and TGA. Efforts at JSC over the past five years in composites have centered on structural polymernanotube systems. Recent activities broadened this focus to multifunctional materials, supercapacitors, fuel cells, regenerable CO2 absorbers, electromagnetic shielding, radiation dosimetry and thermal management systems of interest for human space flight. Preliminary tests indicate improvement of performance in most of these applications because of the large surface area as well as high conductivity exhibited by SWCNTs.

Technologies and methods used for the detection, enrichment and characterization of cancer stem cells.

PubMed

Williams, Anthony; Datar, Ram; Cote, Richard

2010-01-01

Cancer stem cells (CSCs) represent a subclass of tumour cells with the ability for self-renewal, production of differentiated progeny, prolonged survival, resistance to damaging therapeutic agents, and anchorage-independent survival, which together make this population effectively equipped to metastasize, invade and colonize secondary tissues in the face of therapeutic intervention. In recent years, investigators have increasingly focused on the characterization of CSCs to better understand the mechanisms that govern malignant disease progression in an effort to develop more effective, targeted therapeutic agents. The primary obstacle to the study of CSCs, however, is their rarity. Thus, the study of CSCs requires the use of sensitive and efficient technologies for their enrichment and detection. This review discusses technologies and methods that have been adapted and used to isolate and characterize CSCs to date, as well as new potential directions for the enhanced enrichment and detection of CSCs. While the technologies used for CSC enrichment and detection have been useful thus far for their characterization, each approach is not without limitations. Future studies of CSCs will depend on the enhanced sensitivity and specificity of currently available technologies, and the development of novel technologies for increased detection and enrichment of CSCs.

Anticipatory Reward Processing in Addicted Populations: A Focus on the Monetary Incentive Delay Task

PubMed Central

Balodis, Iris M.; Potenza, Marc N.

2014-01-01

Advances in brain imaging techniques have allowed neurobiological research to temporally analyze signals coding for the anticipation of rewards. In addicted populations, both hypo- and hyper-responsiveness of brain regions (e.g., ventral striatum) implicated in drug effects and reward system processing have been reported during anticipation of generalized reward. Here, we discuss the current state of knowledge of reward processing in addictive disorders from a widely used and validated task: the Monetary Incentive Delay Task (MIDT). The current paper constrains review to those studies applying the MIDT in addicted and at-risk adult populations, with a focus on anticipatory processing and striatal regions activated during task performance, as well as the relationship of these regions with individual difference (e.g., impulsivity) and treatment outcome variables. We further review drug influences in challenge studies as a means to examine acute influences on reward processing in abstinent, recreationally using and addicted populations. Here, we discuss that generalized reward processing in addicted and at-risk populations is often characterized by divergent anticipatory signaling in the ventral striatum. Although methodological/task variations may underlie some discrepant findings, anticipatory signaling in the ventral striatum may also be influenced by smoking status, drug metabolites and treatment status in addicted populations. Divergent results across abstinent, recreationally using and addicted populations demonstrate complexities in interpreting findings. Future studies will benefit from focusing on characterizing how impulsivity and other addiction-related features relate to anticipatory striatal signaling over time. Additionally, identifying how anticipatory signals recover/adjust following protracted abstinence will be important in understanding recovery processes. PMID:25481621

Learning in the zone: toward workforce development of evidence-based public policy communication.

PubMed

Meyerson, Beth E; Haderxhanaj, Laura T; Comer, Karen; Zimet, Gregory D

2018-06-05

Evidence-based policy communication (EBPC) is an important, emerging focus in public health research. However, we have yet to understand public health workforce ability to develop and/or use it. The study objective was to characterize capacity to develop and use EBPC and identify cooperative learning and development opportunities using the case of Human papillomavirus (HPV). Vygotsky's Zone of Proximal Development (ZPD) informed guided interviews with 27 advocates in Indiana from government, industry, research, state associations and individuals. Participants focused on HPV, cancer, women's health, school health and minority health. Capacity to develop and use EBPC was reported to develop through cooperative learning opportunities on the job or in advocacy focused coalitions. Coalition learning appeared to translate across health topics. Notably, policy experience did not assure understanding or use of EBPC. The ZPD framework can inform workforce EBPC interventions by focusing on actual development, potential development and factors for learning and development in the ZPD. Future studies should further clarify and evaluate emerging indicators in additional public health policy areas with a larger sample.

Optical characterization of the InFocus TVT-6000 liquid crystal television (LCTV) using custom drive electronics

NASA Astrophysics Data System (ADS)

Duffey, Jason N.; Jones, Brian K.; Loudin, Jeffrey A.; Booth, Joseph J.

1995-03-01

Liquid crystal televisions are popular low-cost spatial light modulators. One LCTV of interest is found in the InFocus TVT-6000 television projector. A wavefront splitting interferometer has been constructed and analyzed for measuring the complex characteristics of these modulators, including phase and amplitude coupling. The results of this evaluation using the TVT-6000 projector drive electronics have been presented in a previous work. This work will present results of the complex characterizations of these modulators using custom drive electronics.

Development and characterization of monolithic multilayer Laue lens nanofocusing optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nazaretski, E.; Xu, W.; Bouet, N.

2016-06-27

We have developed an experimental approach to bond two independent linear Multilayer Laue Lenses (MLLs) together. A monolithic MLL structure was characterized using ptychography at 12 keV photon energy, and we demonstrated 12 nm and 24 nm focusing in horizontal and vertical directions, respectively. Fabrication of 2D MLL optics allows installation of these focusing elements in more conventional microscopes suitable for x-ray imaging using zone plates, and opens easier access to 2D imaging with high spatial resolution in the hard x-ray regime.

Development and characterization of monolithic multilayer Laue lens nanofocusing optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nazaretski, E.; Xu, W., E-mail: weihexu@bnl.gov; Bouet, N.

2016-06-27

We have developed an experimental approach to bond two independent linear Multilayer Laue Lenses (MLLs) together. A monolithic MLL structure was characterized using ptychography at 12 keV photon energy, and we demonstrated 12 nm and 24 nm focusing in horizontal and vertical directions, respectively. Fabrication of 2D MLL optics allows installation of these focusing elements in more conventional microscopes suitable for x-ray imaging using zone plates, and opens easier access to 2D imaging with high spatial resolution in the hard x-ray regime.

Optical elements with extended depth of focus and arbitrary distribution of intensity along the focal segment obtained by angular modulation of the optical power

NASA Astrophysics Data System (ADS)

Kakarenko, K.; Ducin, I.; Jaroszewicz, Z.; Kołodziejczyk, A.; Petelczyc, K.; Stompor, A.; Sypek, M.

2015-04-01

Light Sword Lens (LSL), i.e., an optical element with extended depth of focus (EDOF) characterized by angular modulation of the optical power in its conventional form is characterized by a linear relationship between the optical power and the angular coordinate of the corresponding angular lens sector. This dependence may be manipulated in function of the required design needs. In the present communicate this additional degree of freedom of design is used for elimination of the LSL shape discontinuity.

Crystal structure and optical properties of silver nanorings

NASA Astrophysics Data System (ADS)

Zhou, Li; Fu, Xiao-Feng; Yu, Liao; Zhang, Xian; Yu, Xue-Feng; Hao, Zhong-Hua

2009-04-01

We report the polyol synthesis and crystal structure characterization of silver nanorings, which have perfect circular shape, smooth surface, and elliptical wire cross-section. The characterization results show that the silver nanorings have well-defined crystal of singly twinned along the whole ring. The spatial distribution of the scattering of a silver nanoring with slanted incidence reveals the unique focus effect of the nanoring, and the focus scattering varies with the incident wavelength. The silver nanorings with perfect geometry and well-defined crystal have potential applications in nanoscaled photonics, plasmonic devices, and optical manipulation.

Visual Semiotics & Uncertainty Visualization: An Empirical Study.

PubMed

MacEachren, A M; Roth, R E; O'Brien, J; Li, B; Swingley, D; Gahegan, M

2012-12-01

This paper presents two linked empirical studies focused on uncertainty visualization. The experiments are framed from two conceptual perspectives. First, a typology of uncertainty is used to delineate kinds of uncertainty matched with space, time, and attribute components of data. Second, concepts from visual semiotics are applied to characterize the kind of visual signification that is appropriate for representing those different categories of uncertainty. This framework guided the two experiments reported here. The first addresses representation intuitiveness, considering both visual variables and iconicity of representation. The second addresses relative performance of the most intuitive abstract and iconic representations of uncertainty on a map reading task. Combined results suggest initial guidelines for representing uncertainty and discussion focuses on practical applicability of results.

A Retrospective Analysis of the Benefits and Impacts of U.S. Renewable Portfolio Standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiser, Ryan; Barbose, Galen; Heeter, Jenny

This is the second in a series of reports exploring the costs, benefits, and other impacts of state renewable portfolio standards (RPS), both retrospectively and prospectively. This report focuses on the benefits and impacts of all state RPS programs, in aggregate, for the year 2013 (the most-recent year for which the requisite data were available). Relying on a well-vetted set of methods, the study evaluates a number of important benefits and impacts in both physical and monetary terms, where possible, and characterizes key uncertainties. The prior study in this series focused on historical RPS compliance costs, and future work willmore » evaluate costs, benefits, and other impacts of RPS policies prospectively.« less

Museums and disease: using tissue archive and museum samples to study pathogens.

PubMed

Tsangaras, Kyriakos; Greenwood, Alex D

2012-01-20

Molecular studies of archival and fossil samples have traditionally focused on the nucleic acids derived from the host species. However, there has recently been an increase in ancient DNA research on the identification and characterization of infectious agents within the hosts. The study of pathogens from the past provides great opportunities for discovering the causes of historical infection events, characterizing host-microorganism co-evolution and directly investigating the evolution of specific pathogens. Several research teams have been able to isolate and characterize a variety of different bacterial, parasite and viral microorganisms. However, this emerging field is not without obstacles. The diagenetic processes that make ancient DNA research generally difficult are also impediments to ancient pathogen research and perhaps more so given that their DNA may represent an even rarer proportion of the remaining nucleic acids in a fossil sample than host DNA. However, studies performed under controlled conditions and following stringent ancient DNA protocols can and have yielded reliable and often surprising results. This article reviews the advantages, problems, and failures of ancient microbiological research. Copyright © 2011 Elsevier GmbH. All rights reserved.

RESOLVE Projects: Lunar Water Resource Demonstration and Regolith Volatile Characterization

NASA Technical Reports Server (NTRS)

2008-01-01

To sustain affordable human and robotic space exploration, the ability to live off the land at the exploration site will be essential. NASA calls this ability in situ resource utilization (ISRU) and is focusing on finding ways to sustain missions first on the Moon and then on Mars. The ISRU project aims to develop capabilities to technology readiness level 6 for the Robotic Lunar Exploration Program and early human missions returning to the Moon. NASA is concentrating on three primary areas of ISRU: (1) excavating, handling, and moving lunar regolith, (2) extracting oxygen from lunar regolith, and (3) finding, characterizing, extracting, separating, and storing volatile lunar resources, especially in the permanently shadowed polar craters. To meet the challenges related to technology development for these three primary focus areas, the Regolith and Environment Science and Oxygen and Lunar Volatile Extraction (RESOLVE) project was initiated in February 2005, through funding by the Exploration Systems Mission Directorate. RESOLVE's objectives are to develop requirements and conceptual designs and to perform breadboard concept verification testing of each experiment module. The final goal is to deliver a flight prototype unit that has been tested in a relevant lunar polar environment. Here we report progress toward the third primary area creating ways to find, characterize, extract, separate, and store volatile lunar resources. The tasks include studying thermal, chemical, and electrical ways to collect such volatile resources as hydrogen, water, nitrogen, methane, and ammonia. We approached this effort through two subtasks: lunar water resource demonstration (LWRD) and regolith volatile characterization (RVC).

Characterization of the Deep-Sea Streptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli.

PubMed

Guo, Yunxue; Yao, Jianyun; Sun, Chenglong; Wen, Zhongling; Wang, Xiaoxue

2016-07-01

Toxin-antitoxin (TA) systems are small genetic elements that are ubiquitous in prokaryotes. Most studies on TA systems have focused on commensal and pathogenic bacteria; yet very few studies have focused on TAs in marine bacteria, especially those isolated from a deep sea environment. Here, we characterized a type II VapC/VapB TA system from the deep-sea derived Streptomyces sp. SCSIO 02999. The VapC (virulence-associated protein) protein belongs to the PIN (PilT N-terminal) superfamily. Overproduction of VapC strongly inhibited cell growth and resulted in a bleb-containing morphology in E. coli. The toxicity of VapC was neutralized through direct protein-protein interaction by a small protein antitoxin VapB encoded by a neighboring gene. Antitoxin VapB alone or the VapB/VapC complex negatively regulated the vapBC promoter activity. We further revealed that three conserved Asp residues in the PIN domain were essential for the toxic effect of VapC. Additionally, the VapC/VapB TA system stabilized plasmid in E. coli. Furthermore, VapC cross-activated transcription of several TA operons via a partially Lon-dependent mechanism in E. coli, and the activated toxins accumulated more preferentially than their antitoxin partners. Collectively, we identified and characterized a new deep sea TA system in the deep sea Streptomyces sp. and demonstrated that the VapC toxin in this system can cross-activate TA operons in E. coli.

Interfacial Effects and Organization of Inorganic-Organic Composite Solids.

DTIC Science & Technology

1998-05-20

SITU NMR STUDY OF THE HYDROTHERMAL SYNTHESIS OF TEMPLATE-MEDIATED MICROPOROUS ALUMINOPHOSPHATE MATERIALS, Conne M Gersrdin, Pnnccton Univ, Dept...quantitatively characterize the hydrothermal medium while the synthesis proceeds can yield to a better description of the different steps of the...Inorganic-Organic Composite Solids," focused on recent applications in materials synthesis that use structure-directing agents and self-assembly

Enacting Work Space in the Flow: Sensemaking about Mobile Practices and Blurring Boundaries

ERIC Educational Resources Information Center

Davis, Loni

2013-01-01

An increasing portion of the contemporary workforce is using mobile devices to create new kinds of work-space flows characterized by emergence, liquidity, and the blurring of all kinds of boundaries. This changes the traditional notion of the term "workplace." The present study focuses on how people enact and make sense of new work space…

Complex Life Course Patterns and the Risk of Divorce in Second Marriages

ERIC Educational Resources Information Center

Teachman, Jay

2008-01-01

In this article, I use data on women (N= 655) from the 2002 National Survey of Family Growth to examine the correlates of second marital dissolution. I update the limited number of previous studies on this topic by focusing on the relationships between divorce and the complex life course patterns that characterize respondents in second marriages.…

A Way of Policy Bricolage or Translation: The Case of Taiwan's Higher Education Reform of Quality Assurance

ERIC Educational Resources Information Center

Hsieh, Chuo-Chun

2016-01-01

This paper focuses on the process and mechanism of higher education policy change related to quality assurance in a globalized world. In particular, the purpose of the study was to identify the impact of globalization on domestic policy change in Taiwan, characterized as a peripheral country. Taiwan's experience in terms of developing a national…

Identifying Students at Risk: An Examination of Computer-Adaptive Measures and Latent Class Growth Analysis

ERIC Educational Resources Information Center

Keller-Margulis, Milena; McQuillin, Samuel D.; Castañeda, Juan Javier; Ochs, Sarah; Jones, John H.

2018-01-01

Multitiered systems of support depend on screening technology to identify students at risk. The purpose of this study was to examine the use of a computer-adaptive test and latent class growth analysis (LCGA) to identify students at risk in reading with focus on the use of this methodology to characterize student performance in screening.…

Genes encoding proteins with peritrophin A-type chitin-binding domains in Tribolium castaneum are grouped into three distinct families based on phylogeny, expression and function

USDA-ARS?s Scientific Manuscript database

This study is focused on the characterization and expression of genes in the red flour beetle, Tribolium castaneum, encoding proteins that possess six-cysteine-containing chitin-binding domains (CBDs) related to the peritrophin A domain (ChtBD2). An exhaustive bioinformatics search of the genome of...

Reification in the Learning of Square Roots in a Ninth Grade Classroom: Combining Semiotic and Discursive Approaches

ERIC Educational Resources Information Center

Shinno, Yusuke

2018-01-01

This paper reports on combining semiotic and discursive approaches to reification in classroom interactions. It focuses on the discursive characteristics and semiotic processes involved in the teaching and learning of square roots in a ninth grade classroom in Japan. The purpose of this study is to characterize the development of mathematical…

Review of the synergies between computational modeling and experimental characterization of materials across length scales

DOE PAGES

Dingreville, Rémi; Karnesky, Richard A.; Puel, Guillaume; ...

2015-11-16

With the increasing interplay between experimental and computational approaches at multiple length scales, new research directions are emerging in materials science and computational mechanics. Such cooperative interactions find many applications in the development, characterization and design of complex material systems. This manuscript provides a broad and comprehensive overview of recent trends in which predictive modeling capabilities are developed in conjunction with experiments and advanced characterization to gain a greater insight into structure–property relationships and study various physical phenomena and mechanisms. The focus of this review is on the intersections of multiscale materials experiments and modeling relevant to the materials mechanicsmore » community. After a general discussion on the perspective from various communities, the article focuses on the latest experimental and theoretical opportunities. Emphasis is given to the role of experiments in multiscale models, including insights into how computations can be used as discovery tools for materials engineering, rather than to “simply” support experimental work. This is illustrated by examples from several application areas on structural materials. In conclusion this manuscript ends with a discussion on some problems and open scientific questions that are being explored in order to advance this relatively new field of research.« less

Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Magnuson, Timothy S.

2013-09-10

The biochemistry of bacterial proteins involved in redox transformations of metals and minerals is, without dispute, an important area of research. Nevertheless, most studies on bacterial metal transformation have focused not on biochemistry but on genetics and genomics. The objective of this research is to better understand the role of conformation change in electron transfer from cytochromes to minerals, a process that underpins respiratory metal reduction by bacteria in nature and in bioremediation strategies, including reductive immobilization of radioactive contaminants. Our DOE-funded work is specifically focused on answering long-standing questions about the biochemical behavior of these very interesting proteins, andmore » our findings thus far have already made impacts in the fields of environmental microbiology and biogeochemistry. Among the key findings from the project are 1) Successful large-scale production of biomass for protein isolation; 2) Purification of several c-type cytochromes for biochemical study; 3) Characterization of these proteins using spectrophotometric and electrochemical techniques; 4) Examination of protein conformational change and redox activity towards metal oxides using a small mass cytochrome c from Acidiphilium cryptum; 5) Proteomic characterization of A. cryptum biofilms; 6) Training of 2 undergraduate research assistants; 7) Publications and several meeting presentations.« less

Mechanical Blood Trauma in Assisted Circulation: Sublethal RBC Damage Preceding Hemolysis

PubMed Central

Olia, Salim E.; Maul, Timothy M.; Antaki, James F.; Kameneva, Marina V.

2016-01-01

After many decades of improvements in mechanical circulatory assist devices (CADs), blood damage remains a serious problem during support contributing to variety of adverse events, and consequently affecting patient survival and quality of life. The mechanisms of cumulative cell damage in continuous-flow blood pumps are still not fully understood despite numerous in vitro, in vivo, and in silico studies of blood trauma. Previous investigations have almost exclusively focused on lethal blood damage, namely hemolysis, which is typically negligible during normal operation of current generation CADs. The measurement of plasma free hemoglobin (plfHb) concentration to characterize hemolysis is straightforward, however sublethal trauma is more difficult to detect and quantify since no simple direct test exists. Similarly, while multiple studies have focused on thrombosis within blood pumps and accessories, sublethal blood trauma and its sequelae have yet to be adequately documented or characterized. This review summarizes the current understanding of sublethal trauma to red blood cells (RBCs) produced by exposure of blood to flow parameters and conditions similar to those within CADs. It also suggests potential strategies to reduce and/or prevent RBC sublethal damage in a clinically-relevant context, and encourages new research into this relatively uncharted territory. PMID:27034320

The Environmental Protection Agency's Community-Focused Exposure and Risk Screening Tool (C-FERST) and its potential use for environmental justice efforts.

PubMed

Zartarian, Valerie G; Schultz, Bradley D; Barzyk, Timothy M; Smuts, Marybeth; Hammond, Davyda M; Medina-Vera, Myriam; Geller, Andrew M

2011-12-01

Our primary objective was to provide higher quality, more accessible science to address challenges of characterizing local-scale exposures and risks for enhanced community-based assessments and environmental decision-making. After identifying community needs, priority environmental issues, and current tools, we designed and populated the Community-Focused Exposure and Risk Screening Tool (C-FERST) in collaboration with stakeholders, following a set of defined principles, and considered it in the context of environmental justice. C-FERST is a geographic information system and resource access Web tool under development for supporting multimedia community assessments. Community-level exposure and risk research is being conducted to address specific local issues through case studies. C-FERST can be applied to support environmental justice efforts. It incorporates research to develop community-level data and modeled estimates for priority environmental issues, and other relevant information identified by communities. Initial case studies are under way to refine and test the tool to expand its applicability and transferability. Opportunities exist for scientists to address the many research needs in characterizing local cumulative exposures and risks and for community partners to apply and refine C-FERST.

A Liver-centric Multiscale Modeling Framework for Xenobiotics ...

EPA Pesticide Factsheets

We describe a multi-scale framework for modeling acetaminophen-induced liver toxicity. Acetaminophen is a widely used analgesic. Overdose of acetaminophen can result in liver injury via its biotransformation into toxic product, which further induce massive necrosis. Our study focuses on developing a multi-scale computational model to characterize both phase I and phase II metabolism of acetaminophen, by bridging Physiologically Based Pharmacokinetic (PBPK) modeling at the whole body level, cell movement and blood flow at the tissue level and cell signaling and drug metabolism at the sub-cellular level. To validate the model, we estimated our model parameters by fi?tting serum concentrations of acetaminophen and its glucuronide and sulfate metabolites to experiments, and carried out sensitivity analysis on 35 parameters selected from three modules. Our study focuses on developing a multi-scale computational model to characterize both phase I and phase II metabolism of acetaminophen, by bridging Physiologically Based Pharmacokinetic (PBPK) modeling at the whole body level, cell movement and blood flow at the tissue level and cell signaling and drug metabolism at the sub-cellular level. This multiscale model bridges the CompuCell3D tool used by the Virtual Tissue project with the httk tool developed by the Rapid Exposure and Dosimetry project.

Site-specific characterization of beetle horn shell with micromechanical bending test in focused ion beam system.

PubMed

Lee, Hyun-Taek; Kim, Ho-Jin; Kim, Chung-Soo; Gomi, Kenji; Taya, Minoru; Nomura, Shûhei; Ahn, Sung-Hoon

2017-07-15

Biological materials are the result of years of evolution and possess a number of efficient features and structures. Researchers have investigated the possibility of designing biomedical structures that take advantage of these structural features. Insect shells, such as beetle shells, are among the most promising types of biological material for biomimetic development. However, due to their intricate geometries and small sizes, it is challenging to measure the mechanical properties of these microscale structures. In this study, we developed an in-situ testing platform for site-specific experiments in a focused ion beam (FIB) system. Multi-axis nano-manipulators and a micro-force sensor were utilized in the testing platform to allow better results in the sample preparation and data acquisition. The entire test protocol, consisting of locating sample, ion beam milling and micro-mechanical bending tests, can be carried out without sample transfer or reattachment. We used our newly devised test platform to evaluate the micromechanical properties and structural features of each separated layer of the beetle horn shell. The Young's modulus of both the exocuticle and endocuticle layers was measured. We carried out a bending test to characterize the layers mechanically. The exocuticle layer bent in a brick-like manner, while the endocuticle layer exhibited a crack blunting effect. This paper proposed an in-situ manipulation/test method in focused ion beam for characterizing micromechanical properties of beetle horn shell. The challenge in precise and accurate fabrication for the samples with complex geometry was overcome by using nano-manipulators having multi-degree of freedom and a micro-gripper. With the aid of this specially designed test platform, bending tests were carried out on cantilever-shaped samples prepared by focused ion beam milling. Structural differences between exocuticle and endocuticle layers of beetle horn shell were explored and the results provided insight into the structural advantages of each biocomposite structure. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Acoustic characterization of high intensity focused ultrasound fields generated from a transmitter with a large aperture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Tao; Fan, Tingbo; Jiangsu Province Institute for Medical Equipment Testing, Nanjing 210012

Prediction and measurement of the acoustic field emitted from a high intensity focused ultrasound (HIFU) is essential for the accurate ultrasonic treatment. In this study, the acoustic field generated from a strongly focused HIFU transmitter was characterized by a combined experiment and simulation method. The spheroidal beam equation (SBE) was utilized to describe the nonlinear sound propagation. The curve of the source pressure amplitude versus voltage excitation was determined by fitting the measured ratio of the second harmonic to the fundamental component of the focal waveform to the simulation result; finally, the acoustic pressure field generated by the strongly focusedmore » HIFU transmitter was predicted by using the SBE model. A commercial fiber optic probe hydrophone was utilized to measure the acoustic pressure field generated from a 1.1 MHz HIFU transmitter with a large half aperture angle of 30°. The maximum measured peak-to-peak pressure was up to 72 MPa. The validity of this combined approach was confirmed by the comparison between the measured results and the calculated ones. The results indicate that the current approach might be useful to describe the HIFU field. The results also suggest that this method is not valid for low excitations owing to low sensitivity of the second harmonic.« less

Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening

NASA Astrophysics Data System (ADS)

Wu, Sheng-Kai; Chu, Po-Chun; Chai, Wen-Yen; Kang, Shih-Tsung; Tsai, Chih-Hung; Fan, Ching-Hsiang; Yeh, Chih-Kuang; Liu, Hao-Li

2017-04-01

Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). However, limited understanding is available regarding the effect of different microbubbles to induce BBB opening. The aim of this study is to characterize different MBs on their effect in FUS-induced BBB opening. Three MBs, SonoVue, Definity, and USphere, were tested, with 0.4-MHz FUS exposure at 0.62-1.38 of mechanical index (MI) on rats. Evans blue, dynamic contrast-enhanced (DCE) MRI and small-animal ultrasound imaging were used as surrogates to allow molecule-penetrated quantification, BBB-opened observation, and MBs circulation/persistence. Cavitation activity was measured via the passive cavitation detection (PCD) setup to correlate with the exposure level and the histological effect. Under given and identical MB concentrations, the three MBs induced similar and equivalent BBB-opening effects and persistence. In addition, a treatment paradigm by adapting exposure time is proposed to compensate MB decay to retain the persistence of BBB-opening efficiency in multiple FUS exposures. The results potentially improve understanding of the equivalence among MBs in focused ultrasound CNS drug delivery, and provide an effective strategy for securing persistence in this treatment modality.

Highway runoff stormwater management potential (HRSMP) site characterization using NASA public domain imagery.

DOT National Transportation Integrated Search

2016-04-01

The focus of this research project was the development of geospatial technology (GST) methodology to : characterize and evaluate highway runoff stormwater management potential (HRSMP) sites in order to : reduce their impact on properties, save lives ...

Current approaches used in epidemiologic studies to examine short-term multipollutant air pollution exposures.

PubMed

Davalos, Angel D; Luben, Thomas J; Herring, Amy H; Sacks, Jason D

2017-02-01

Air pollution epidemiology traditionally focuses on the relationship between individual air pollutants and health outcomes (e.g., mortality). To account for potential copollutant confounding, individual pollutant associations are often estimated by adjusting or controlling for other pollutants in the mixture. Recently, the need to characterize the relationship between health outcomes and the larger multipollutant mixture has been emphasized in an attempt to better protect public health and inform more sustainable air quality management decisions. New and innovative statistical methods to examine multipollutant exposures were identified through a broad literature search, with a specific focus on those statistical approaches currently used in epidemiologic studies of short-term exposures to criteria air pollutants (i.e., particulate matter, carbon monoxide, sulfur dioxide, nitrogen dioxide, and ozone). Five broad classes of statistical approaches were identified for examining associations between short-term multipollutant exposures and health outcomes, specifically additive main effects, effect measure modification, unsupervised dimension reduction, supervised dimension reduction, and nonparametric methods. These approaches are characterized including advantages and limitations in different epidemiologic scenarios. By highlighting the characteristics of various studies in which multipollutant statistical methods have been used, this review provides epidemiologists and biostatisticians with a resource to aid in the selection of the most optimal statistical method to use when examining multipollutant exposures. Published by Elsevier Inc.

Small acid soluble proteins for rapid spore identification.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Branda, Steven S.; Lane, Todd W.; VanderNoot, Victoria A.

2006-12-01

This one year LDRD addressed the problem of rapid characterization of bacterial spores such as those from the genus Bacillus, the group that contains pathogenic spores such as B. anthracis. In this effort we addressed the feasibility of using a proteomics based approach to spore characterization using a subset of conserved spore proteins known as the small acid soluble proteins or SASPs. We proposed developing techniques that built on our previous expertise in microseparations to rapidly characterize or identify spores. An alternative SASP extraction method was developed that was amenable to both the subsequent fluorescent labeling required for laser-induced fluorescencemore » detection and the low ionic strength requirements for isoelectric focusing. For the microseparations, both capillary isoelectric focusing and chip gel electrophoresis were employed. A variety of methods were evaluated to improve the molecular weight resolution for the SASPs, which are in a molecular weight range that is not well resolved by the current methods. Isoelectric focusing was optimized and employed to resolve the SASPs using UV absorbance detection. Proteomic signatures of native wild type Bacillus spores and clones genetically engineered to produce altered SASP patterns were assessed by slab gel electrophoresis, capillary isoelectric focusing with absorbance detection as well as microchip based gel electrophoresis employing sensitive laser-induced fluorescence detection.« less

Doped biocompatible layers prepared by laser

NASA Astrophysics Data System (ADS)

Jelínek, M.; Weiserová, M.; Kocourek, T.; Jurek, K.; Strnad, J.

2010-03-01

The contribution deals with KrF laser synthesis and study of doped biocompatible materials with focus on diamond-like carbon (DLC) and hydroxyapatite (HA). Overview of materials used for dopation is given. Experimental results of study of HA layers doped with silver are presented. Films properties were characterized using profilometer, SEM, WDX, XRD and optical transmission. Content of silver in layers moved from 0.06 to 13.7 at %. The antibacterial properties of HA, silver and doped HA layers were studied in vivo using Escherichia coli cells.

Consortium for Molecular Characterization of Screen-Detected Lesions Created: Eight Grants Awarded | Division of Cancer Prevention

Cancer.gov

The NCI has awarded eight grants to create the Consortium for Molecular Characterization of Screen-Detected Lesions. The consortium has seven molecular characterization laboratories (MCLs) and a coordinating center, and is supported by the Division of Cancer Prevention and the Division of Cancer Biology. | 7 laboratories and a coordinating center focused on identifying

Fundamental remote sensing science research program. Part 1: Scene radiation and atmospheric effects characterization project

NASA Technical Reports Server (NTRS)

Murphy, R. E.; Deering, D. W.

1984-01-01

Brief articles summarizing the status of research in the scene radiation and atmospheric effect characterization (SRAEC) project are presented. Research conducted within the SRAEC program is focused on the development of empirical characterizations and mathematical process models which relate the electromagnetic energy reflected or emitted from a scene to the biophysical parameters of interest.

Electromagnetic diagnostic techniques for hypervelocity projectile detection, velocity measurement, and size characterization: Theoretical concept and first experimental test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uhlig, W. Casey; Heine, Andreas, E-mail: andreas.heine@emi.fraunhofer.de

2015-11-14

A new measurement technique is suggested to augment the characterization and understanding of hypervelocity projectiles before impact. The electromagnetic technique utilizes magnetic diffusion principles to detect particles, measure velocity, and indicate relative particle dimensions. It is particularly suited for detection of small particles that may be difficult to track utilizing current characterization methods, such as high-speed video or flash radiography but can be readily used for large particle detection, where particle spacing or location is not practical for other measurement systems. In this work, particles down to 2 mm in diameter have been characterized while focusing on confining the detection signalmore » to enable multi-particle characterization with limited particle-to-particle spacing. The focus of the paper is on the theoretical concept and the analysis of its applicability based on analytical and numerical calculation. First proof-of-principle experimental tests serve to further validate the method. Some potential applications are the characterization of particles from a shaped-charge jet after its break-up and investigating debris in impact experiments to test theoretical models for the distribution of particles size, number, and velocity.« less

Characterizing the Preturbulence Environment for Sensor Development, New Hazard Algorithms and NASA Experimental Flight Planning

NASA Technical Reports Server (NTRS)

Kaplan, Michael L.; Lin, Yuh-Lang

2004-01-01

During the grant period, several tasks were performed in support of the NASA Turbulence Prediction and Warning Systems (TPAWS) program. The primary focus of the research was on characterizing the preturbulence environment by developing predictive tools and simulating atmospheric conditions that preceded severe turbulence. The goal of the research being to provide both dynamical understanding of conditions that preceded turbulence as well as providing predictive tools in support of operational NASA B-757 turbulence research flights. The advancements in characterizing the preturbulence environment will be applied by NASA to sensor development for predicting turbulence onboard commercial aircraft. Numerical simulations with atmospheric models as well as multi-scale observational analyses provided insights into the environment organizing turbulence in a total of forty-eight specific case studies of severe accident producing turbulence on commercial aircraft. These accidents exclusively affected commercial aircraft. A paradigm was developed which diagnosed specific atmospheric circulation systems from the synoptic scale down to the meso-y scale that preceded turbulence in both clear air and in proximity to convection. The emphasis was primarily on convective turbulence as that is what the TPAWS program is most focused on in terms of developing improved sensors for turbulence warning and avoidance. However, the dynamical paradigm also has applicability to clear air and mountain turbulence. This dynamical sequence of events was then employed to formulate and test new hazard prediction indices that were first tested in research simulation studies and then ultimately were further tested in support of the NASA B-757 turbulence research flights. The new hazard characterization algorithms were utilized in a Real Time Turbulence Model (RTTM) that was operationally employed to support the NASA B-757 turbulence research flights. Improvements in the RTTM were implemented in an effort to increase the accuracy of the operational characterization of the preturbulence environment. Additionally, the initial research necessary to create a statistical evaluation scheme for the characterization indices utilized in the RTTM was undertaken. Results of all components of this research were then published in NASA contractor reports and scientific journal papers.

Characterization of the seascape used by juvenile and wintering adult Southern Giant Petrels from Patagonia Argentina

NASA Astrophysics Data System (ADS)

Blanco, Gabriela S.; Pisoni, Juan P.; Quintana, Flavio

2015-02-01

The characterization of the seascape used by marine top predators provides a wide perspective of pelagic habitat use and it is necessary to understand the functioning of marine systems. The goal of this study was to characterize the oceanographic and biological features of marine areas used by adult and first year juvenile southern giant petrels (SGP, Macronectes giganteus) from northern Patagonian colonies (Isla Arce and Gran Robredo) during the austral fall and winter (2005, 2006, 2007, and 2008). The marine environment exploited by the SGP was characterized using sea surface temperature (SST), SST gradients, chlorophyll-a concentration, water depth, oceanographic regimes, and ocean surface winds. In addition, the biological seascape was defined by considering the distribution of squid during the months of study. Juveniles SGP exploited a wide range of environments focusing mainly on productive neritic waters using a variety of oceanographic regimes. Juveniles were exposed to eutrophic and enriched waters, probably because of the frequent presence of thermal fronts in their utilization areas. Adults' environments lacked of thermal fronts remaining the majority of their time within the oceanographic regime "Continental Shelf", in water depths of 100-200 m, exploiting mesotrophic and eutrophic environments, and remaining in areas of known food resources related to the presence of squid. For the most part, juveniles were exposed to westerly winds, which may have helped them in their initial flight to the shelf break, east of the colony. Wintering adults SGP also explored areas characterized by westerly winds but this did not play a primary role in the selection of their residence areas. Juveniles during their first year at sea have to search for food exploring a variety of unknown environments. During their search, they remained in productive environments associated to fronts and probably also associated to fisheries operating in their foraging areas. The understanding of pelagic birds' habitat selection and preferences through the year is crucial for the monitoring of anthropogenic impacts over these species. Further studies should focus on the prediction of variables that determine the distribution of these species though the year and during different life stages.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cipolla, C.L.; Mayerhofer, M.

The paper details the acquisition of detailed core and pressure data and the subsequent reservoir modeling in the Ozona Gas Field, Crockett County, Texas. The Canyon formation is the focus of the study and consists of complex turbidite sands characterized by numerous lenticular gas bearing members. The sands cannot be characterized using indirect measurements (logs) and no reliable porosity-permeability relationship could be developed. The reservoir simulation results illustrate the problems associated with interpreting typical pressure and production data in tight gas sands and details procedures to identify incremental reserves. Reservoir layering was represented by five model layers and layer permeabilitiesmore » were estimated based on statistical distributions from core measurements.« less

Characterization of Microporous Insulation, Microsil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, R.

Microsil microporous insulation has been characterized by Lawrence Livermore National Laboratory for possible use in structural and thermal applications in the DPP-1 design. Qualitative test results have provided mechanical behavioral characteristics for DPP-1 design studies and focused on the material behavioral response to being crushed, cyclically loaded, and subjected to vibration for a confined material with an interference fit or a radial gap. Quantitative test results have provided data to support the DPP-1 FEA model analysis and verification and were used to determine mechanical property values for the material under a compression load. The test results are documented within thismore » report.« less

Changes in parental self-identity following the death of a child to cancer.

PubMed

O'Connor, Kathleen; Barrera, Maru

2014-01-01

This study explored parental self-identity at 6, 12, and 18 months following the death of a child to cancer. Semi-structured interviews were analyzed using qualitative methodology. Two patterns of parental self-identity emerged: identity reintegration, characterized by 6 associated themes (e.g., positive reframing, focusing on surviving children); and identity disintegration, characterized by 7 associated themes (e.g., negative perceptions of social support, self-destructive thoughts and behaviors). Patterns were stable from 6 to 12 months, but a shift towards identity disintegration was observed at 18 months. These findings suggest a need to support bereaved parents' well-being beyond the first year post-death.

Investigations into Performance and Lifetime Enhancements of OPV Devices: Cooperative Research and Development Final Report, CRADA Number CRD-08-263

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginley, D.

2014-06-01

To evaluate Plextronics new additives and derivatives in lithium-ion Battery Applications, Plextronics will provide to NREL, a starting point, including materials and initial data for proof of concept. The central focus of this project is to acertain the nature of the efficacy of the Plextronics additives through physical and electrical characterization, including evaluations of new derivatives, system evaluations on batteries made with Plexcore and to study long term cycling performance differences. The initial focus is to establish Plexcore mode of action to support the commercialization of the first commercial evaluations of Plexcore in Sept. 2013.

Recent developments in pediatric headache.

PubMed

Hershey, Andrew D

2010-06-01

This review will focus on some of the recent findings in pediatric headache including headache characteristics, epidemiology, comorbid associations and treatment updates. Pediatric headache remains a frequent health problem for children and their families, yet there remain many gaps in our knowledge. This review will broadly address some of the recent findings and highlight the gaps in our understanding and treatment of pediatric headache. There will be a focus on pediatric migraine as this has been the best characterized and studied. Our understanding of pediatric headache is improving with increased recognition of the characteristics and associated symptomology. This should further guide the individualized treatment approaches for improved outcome and reduction of progression into adulthood.

A Review of the Structural Characteristics of Family Meals with Children in the United States12

PubMed Central

McCullough, Mary Beth; Robson, Shannon M; Stark, Lori J

2016-01-01

Family meals are associated with a range of positive outcomes among children and adolescents. There is inconsistency, however, in the way in which studies have defined and measured family meals. Therefore, a systematic review of the literature was conducted to determine how studies describe family meals with the use of structural characteristics. The current review focused on studies in the United States that included children ages 2–18 y. A total of 33 studies were identified that characterized family meals with the use of ≥1 of the following structural features: frequency or mean number of family meals per week, length of family meal, people present at meal, and where meals occurred. No study characterized family meals by using all 4 family meal features, whereas most studies (81%) characterized family meals by using frequency or mean number of meals per week. Findings not only provide an initial understanding of the structural features used to define family meals but also point to the importance of developing a more comprehensive, sensitive assessment that can accurately capture the complex and multidimensional nature of family meals. PMID:27422500

A Review of the Structural Characteristics of Family Meals with Children in the United States.

PubMed

McCullough, Mary Beth; Robson, Shannon M; Stark, Lori J

2016-07-01

Family meals are associated with a range of positive outcomes among children and adolescents. There is inconsistency, however, in the way in which studies have defined and measured family meals. Therefore, a systematic review of the literature was conducted to determine how studies describe family meals with the use of structural characteristics. The current review focused on studies in the United States that included children ages 2-18 y. A total of 33 studies were identified that characterized family meals with the use of ≥1 of the following structural features: frequency or mean number of family meals per week, length of family meal, people present at meal, and where meals occurred. No study characterized family meals by using all 4 family meal features, whereas most studies (81%) characterized family meals by using frequency or mean number of meals per week. Findings not only provide an initial understanding of the structural features used to define family meals but also point to the importance of developing a more comprehensive, sensitive assessment that can accurately capture the complex and multidimensional nature of family meals. © 2016 American Society for Nutrition.

Recent mass spectrometry-based techniques and considerations for disulfide bond characterization in proteins.

PubMed

Lakbub, Jude C; Shipman, Joshua T; Desaire, Heather

2018-04-01

Disulfide bonds are important structural moieties of proteins: they ensure proper folding, provide stability, and ensure proper function. With the increasing use of proteins for biotherapeutics, particularly monoclonal antibodies, which are highly disulfide bonded, it is now important to confirm the correct disulfide bond connectivity and to verify the presence, or absence, of disulfide bond variants in the protein therapeutics. These studies help to ensure safety and efficacy. Hence, disulfide bonds are among the critical quality attributes of proteins that have to be monitored closely during the development of biotherapeutics. However, disulfide bond analysis is challenging because of the complexity of the biomolecules. Mass spectrometry (MS) has been the go-to analytical tool for the characterization of such complex biomolecules, and several methods have been reported to meet the challenging task of mapping disulfide bonds in proteins. In this review, we describe the relevant, recent MS-based techniques and provide important considerations needed for efficient disulfide bond analysis in proteins. The review focuses on methods for proper sample preparation, fragmentation techniques for disulfide bond analysis, recent disulfide bond mapping methods based on the fragmentation techniques, and automated algorithms designed for rapid analysis of disulfide bonds from liquid chromatography-MS/MS data. Researchers involved in method development for protein characterization can use the information herein to facilitate development of new MS-based methods for protein disulfide bond analysis. In addition, individuals characterizing biotherapeutics, especially by disulfide bond mapping in antibodies, can use this review to choose the best strategies for disulfide bond assignment of their biologic products. Graphical Abstract This review, describing characterization methods for disulfide bonds in proteins, focuses on three critical components: sample preparation, mass spectrometry data, and software tools.

Characterization of uncertainty in ETMS flight events predictions and its effect on traffic demand predictions

DOT National Transportation Integrated Search

2008-07-11

This report presents the results of analysis and characterization of uncertainty in traffic demand predictions using ETMS data and probabilistic representation of the predictions. Our previous research, described in two prior reports, was focused on ...

Biophysics of α-Synuclein Membrane Interactions

PubMed Central

Pfefferkorn, Candace M.; Jiang, Zhiping; Lee, Jennifer C.

2011-01-01

Membrane proteins participate in nearly all cellular processes; however, because of experimental limitations, their characterization lags far behind that of soluble proteins. Peripheral membrane proteins are particularly challenging to study because of their inherent propensity to adopt multiple and/or transient conformations in solution and upon membrane association. In this review, we summarize useful biophysical techniques for the study of peripheral membrane proteins and their application in the characterization of the membrane interactions of the natively unfolded and Parkinson’s disease (PD) related protein, α-synuclein (α-syn). We give particular focus to studies that have led to the current understanding of membrane-bound α-syn structure and the elucidation of specific membrane properties that affect α-syn-membrane binding. Finally, we discuss biophysical evidence supporting a key role for membranes and α-syn in PD pathogenesis. PMID:21819966

Multi-element isotope fractionation concepts to characterize the biodegradation of hydrocarbons - from enzymes to the environment.

PubMed

Vogt, Carsten; Dorer, Conrad; Musat, Florin; Richnow, Hans-Hermann

2016-10-01

Multi-element compound-specific isotope fractionation (ME-CSIA) has become a state-of-the-art approach for identifying biotransformation reactions. In the last decade, several studies focused on the combined analysis of carbon and hydrogen stable isotopes upon biodegradation of hydrocarbons due to its widespread environmental occurrence as contaminants, often in high concentrations. Most known initial transformation reactions of hydrocarbons have been isotopically characterized in laboratory experiments using model cultures. The data suggest that several of these reactions - especially those occurring under anoxic conditions - can be identified by ME-CSIA, although a number of constraints have been realized which may lead to wrong ME-CSIA data interpretations in field studies. Generally, the applicability of ME-CSIA regarding hydrocarbon biodegradation needs to be corroborated in future field studies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Growth and nanomechanical characterization of nanoscale 3D architectures grown via focused electron beam induced deposition

DOE PAGES

Lewis, Brett B.; Mound, Brittnee A.; Srijanto, Bernadeta; ...

2017-10-12

Here, nanomechanical measurements of platinum–carbon 3D nanoscale architectures grown via focused electron beam induced deposition (FEBID) were performed using a nanoindentation system in a scanning electron microscope (SEM) for simultaneous in situ imaging.

Direct measurement and characterization of active photosynthesis zones inside biofuel producing and wastewater remediating microalgal biofilms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernstein, Hans C.; Kesaano, Maureen; Moll, Karen

2014-03-01

Abstract: Microalgal biofilm based technologies are of keen interest due to their high biomass concentrations and ability to utilize renewable resources, such as light and CO2. While photoautotrophic biofilms have long been used for wastewater remediation applications, biofuel production represents a relatively new and under-represented focus area. However, the direct measurement and characterization of fundamental parameters required for physiological analyses are challenging due to biofilm heterogeneity. This study evaluated oxygenic photosynthesis and biofuel precursor molecule production using a novel rotating algal biofilm reactor (RABR) operated at field- and laboratory-scales for wastewater remediation and biofuel production, respectively. Clear differences in oxygenic-photosynthesis,more » respiration and biofuel-precursor capacities were observed between the two systems and different conditions based on light and nitrogen availability. Nitrogen depletion was not found to have the same effect on lipid accumulation compared to prior planktonic studies. Physiological characterizations of these microalgal biofilms identify potential areas for future process optimization.« less

Characterization of a sustainable sulfur polymer concrete using activated fillers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moon, Juhyuk; Kalb, Paul D.; Milian, Laurence

Sulfur polymer concrete (SPC) is a thermoplastic composite concrete consisting of chemically modified sulfur polymer and aggregates. This study focused on the characterization of a new SPC that has been developed as a sustainable construction material. It is made from industrial by-product sulfur that is modified with activated fillers of fly ash, petroleum refinery residual oil, and sand. Unlike conventional sulfur polymer cements made using dicyclopentadiene as a chemical modifier, the use of inexpensive industrial by-products enables the new SPC to cost-effectively produce sustainable, low-carbon, thermoplastic binder that can compete with conventional hydraulic cement concretes. A series of characterization analysesmore » was conducted including thermal analysis, X-ray diffraction, and spatially-resolved Xray absorption spectroscopy to confirm the polymerization of sulfur induced from the presence of the oil. In addition, mechanical testing, internal pore structure analysis, and scanning electron microscope studies evaluate the performance of this new SPC as a sustainable construction material with a reduced environmental impact.« less

Biopharmaceutical considerations and characterizations in development of colon targeted dosage forms for inflammatory bowel disease.

PubMed

Malayandi, Rajkumar; Kondamudi, Phani Krishna; Ruby, P K; Aggarwal, Deepika

2014-04-01

Colon targeted dosage forms have been extensively studied for the localized treatment of inflammatory bowel disease. These dosage forms not only improve the therapeutic efficacy but also reduce the incidence of adverse drug reactions and hence improve the patient compliance. However, complex and highly variable gastro intestinal physiology limits the clinical success of these dosage forms. Biopharmaceutical characteristics of these dosage forms play a key role in rapid formulation development and ensure the clinical success. The complexity in product development and clinical success of colon targeted dosage forms are based on the biopharmaceutical characteristics such as physicochemical properties of drug substances, pharmaceutical characteristics of dosage form, physiological conditions and pharmacokinetic properties of drug substances as well as drug products. Various in vitro and in vivo techniques have been employed in past to characterize the biopharmaceutical properties of colon targeted dosage forms. This review focuses on the factors influencing the biopharmaceutical performances of the dosage forms, in vitro characterization techniques and in vivo studies.

Morphological characterization of coral reefs by combining lidar and MBES data: A case study from Yuanzhi Island, South China Sea

NASA Astrophysics Data System (ADS)

Zhang, Kai; Yang, Fanlin; Zhang, Hande; Su, Dianpeng; Li, QianQian

2017-06-01

The correlation between seafloor morphological features and biological complexity has been identified in numerous recent studies. This research focused on the potential for accurate characterization of coral reefs based on high-resolution bathymetry from multiple sources. A standard deviation (STD) based method for quantitatively characterizing terrain complexity was developed that includes robust estimation to correct for irregular bathymetry and a calibration for the depth-dependent variablity of measurement noise. Airborne lidar and shipborne sonar bathymetry measurements from Yuanzhi Island, South China Sea, were merged to generate seamless high-resolution coverage of coral bathymetry from the shoreline to deep water. The new algorithm was applied to the Yuanzhi Island surveys to generate maps of quantitive terrain complexity, which were then compared to in situ video observations of coral abundance. The terrain complexity parameter is significantly correlated with seafloor coral abundance, demonstrating the potential for accurately and efficiently mapping coral abundance through seafloor surveys, including combinations of surveys using different sensors.

Direct measurement and characterization of active photosynthesis zones inside wastewater remediating and biofuel producing microalgal biofilms.

PubMed

Bernstein, Hans C; Kesaano, Maureen; Moll, Karen; Smith, Terence; Gerlach, Robin; Carlson, Ross P; Miller, Charles D; Peyton, Brent M; Cooksey, Keith E; Gardner, Robert D; Sims, Ronald C

2014-03-01

Microalgal biofilm based technologies are of keen interest due to their high biomass concentrations and ability to utilize light and CO2. While photoautotrophic biofilms have long been used for wastewater remediation, biofuel production represents a relatively new and under-represented focus area. However, the direct measurement and characterization of fundamental parameters required for industrial control are challenging due to biofilm heterogeneity. This study evaluated oxygenic photosynthesis and respiration on two distinct microalgal biofilms cultured using a novel rotating algal biofilm reactor operated at field- and laboratory-scales. Clear differences in oxygenic photosynthesis and respiration were observed based on different culturing conditions, microalgal composition, light intensity and nitrogen availability. The cultures were also evaluated as potential biofuel synthesis strategies. Nitrogen depletion was not found to have the same effect on lipid accumulation compared to traditional planktonic microalgal studies. Physiological characterizations of these microalgal biofilms identify fundamental parameters needed to understand and control process optimization. Published by Elsevier Ltd.

Characterization of a sustainable sulfur polymer concrete using activated fillers

DOE PAGES

Moon, Juhyuk; Kalb, Paul D.; Milian, Laurence; ...

2016-01-02

Sulfur polymer concrete (SPC) is a thermoplastic composite concrete consisting of chemically modified sulfur polymer and aggregates. This study focused on the characterization of a new SPC that has been developed as a sustainable construction material. It is made from industrial by-product sulfur that is modified with activated fillers of fly ash, petroleum refinery residual oil, and sand. Unlike conventional sulfur polymer cements made using dicyclopentadiene as a chemical modifier, the use of inexpensive industrial by-products enables the new SPC to cost-effectively produce sustainable, low-carbon, thermoplastic binder that can compete with conventional hydraulic cement concretes. A series of characterization analysesmore » was conducted including thermal analysis, X-ray diffraction, and spatially-resolved Xray absorption spectroscopy to confirm the polymerization of sulfur induced from the presence of the oil. In addition, mechanical testing, internal pore structure analysis, and scanning electron microscope studies evaluate the performance of this new SPC as a sustainable construction material with a reduced environmental impact.« less

Technical, economic, and environmental impact study of converting Uzbekistan transportation fleets to natural gas operation. Export trade information

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-04-30

This study, conducted by Radian International, was funded by the U.S. Trade and Development Agency. The report assesses the feasibility (technical, economic and environmental) of converting the Uzbek transportation fleets to natural gas operation. The study focuses on the conversion of high fuel use vehicles and locomotives to liquefied natural gas (LNG) and the conversion of moderate fuel use veicles to compressed natural gas (CNG). The report is divided into the following sections: Executive Summary; (1.0) Introduction; (2.0) Country Background; (3.0) Characterization of Uzbek Transportation Fuels; (4.0) Uzbek Vehicle and Locomotive Fleet Characterization; (5.0) Uzbek Natural Gas Vehicle Conversion Shops;more » (6.0) Uzbek Natural Gas Infrastructure; (7.0) Liquefied Natural Gas (LNG) for Vehicular Fuel in Uzbekistan; (8.0) Economic Feasibility Study; (9.0) Environmental Impact Analysis; References; Appendices A - S.« less

Optimization and characterization of gluten-free spaghetti enriched with chickpea flour.

PubMed

Padalino, Lucia; Mastromatteo, Marcella; Lecce, Lucia; Spinelli, Sara; Conte, Amalia; Del Nobile, M Alessandro

2015-03-01

This work was focused on the optimization and characterization of maize-based spaghetti fortified with chickpea flour. To the aim, the study has been organized in two subsequent trials. In the first one, the chickpea flour amount added to the spaghetti was continuously increased until the overall sensory quality of pasta reached its sensory threshold. Spaghetti samples loaded with 15% chickpea flour showed poor elasticity and increased firmness, so this concentration represented the highest chickpea flour concentration to be used. The second experimental step was aimed to improve the overall sensory quality of the enriched spaghetti by means of hydrocolloids as pectin, guar flour and agar. Final pasta was characterized for the nutritional composition, the glycemic response and the main quality attributes. The best results were obtained by the addition of guar flour.

Bacteriocins from Lactobacillus plantarum – production, genetic organization and mode of action

PubMed Central

Todorov, Svetoslav D.

2009-01-01

Bacteriocins are biologically active proteins or protein complexes that display a bactericidal mode of action towards usually closely related species. Numerous strains of bacteriocin producing Lactobacillus plantarum have been isolated in the last two decades from different ecological niches including meat, fish, fruits, vegetables, and milk and cereal products. Several of these plantaricins have been characterized and the aminoacid sequence determined. Different aspects of the mode of action, fermentation optimization and genetic organization of the bacteriocin operon have been studied. However, numerous of bacteriocins produced by different Lactobacillus plantarum strains have not been fully characterized. In this article, a brief overview of the classification, genetics, characterization, including mode of action and production optimization for bacteriocins from Lactic Acid Bacteria in general, and where appropriate, with focus on bacteriocins produced by Lactobacillus plantarum, is presented. PMID:24031346

Myocardial Tissue Characterization by Magnetic Resonance Imaging

PubMed Central

Ferreira, Vanessa M.; Piechnik, Stefan K.; Robson, Matthew D.; Neubauer, Stefan

2014-01-01

Cardiac magnetic resonance (CMR) imaging is a well-established noninvasive imaging modality in clinical cardiology. Its unsurpassed accuracy in defining cardiac morphology and function and its ability to provide tissue characterization make it well suited for the study of patients with cardiac diseases. Late gadolinium enhancement was a major advancement in the development of tissue characterization techniques, allowing the unique ability of CMR to differentiate ischemic heart disease from nonischemic cardiomyopathies. Using T2-weighted techniques, areas of edema and inflammation can be identified in the myocardium. A new generation of myocardial mapping techniques are emerging, enabling direct quantitative assessment of myocardial tissue properties in absolute terms. This review will summarize recent developments involving T1-mapping and T2-mapping techniques and focus on the clinical applications and future potential of these evolving CMR methodologies. PMID:24576837

The evolution of Yellowstone's magmatic system over the past 630 kyr: Insights from the crystal record

NASA Astrophysics Data System (ADS)

Stelten, M. E.

2017-12-01

The Yellowstone Plateau volcanic field in northwestern Wyoming is one of the world's largest, active silicic volcanic centers, and has produced three caldera-forming "super eruptions" over the past 2.1 Myr. As a result, the petrologic evolution of Yellowstone's magmatic system has been the focus of numerous studies over the past 60 years. Early studies at Yellowstone focused on characterizing whole-rock chemical and isotopic variations observed in magmas erupted over Yellowstone's lifetime. While these have provided important insights into the source of Yellowstone magmas and the processes controlling their compositional evolution though time, whole-rock studies are limited in their ability to identify the mechanisms and timescales of rhyolite generation. In contrast, much of the recent work at Yellowstone has focused on applying micro-analytical techniques to characterize the age and composition of phenocrysts hosted in Yellowstone rhyolites. These studies have greatly advanced our understanding of the magmatic system at Yellowstone and have provided crucial new insights into the mechanisms and timescales of rhyolite generation. In particular, recent work has focused on applying micro-analytical techniques to study the age and origin of the [1] three caldera-forming eruptions that produced the Huckleberry Ridge, Mesa Falls, Lava Creek tuffs and [2] post-Lava Creek tuff intracaldera rhyolites that compose the Plateau Rhyolite. As a result, a wealth of crystal-chemical data now exists for rhyolites erupted throughout Yellowstone's 2.1 Myr history. These data provide a unique opportunity to create a detailed reconstruction of Yellowstone's magmatic system through time. In this contribution, I integrate available age, chemical, and isotopic data for phenocrysts hosted in Yellowstone rhyolites to construct a model for the evolution of Yellowstone's magmatic system from the caldera-forming eruption of the Lava Creek tuff at ca. 0.63 Ma to the present day. In particular, I highlight new insights into [1] the physical nature of Yellowstone's magmatic system, [2] the ways in which the mechanisms and timescales of rhyolite generation have changed though time, and [3] implications for the current state of the Yellowstone's magmatic system.

A range-based method to calibrate a magnetic spectrometer measuring the energy spectrum of the backward electron beam of a plasma focus.

PubMed

Ceccolini, E; Rocchi, F; Mostacci, D; Sumini, M; Tartari, A

2011-08-01

The electron beam emitted from the back of plasma focus devices is being studied as a radiation source for intraoperative radiation therapy applications. A plasma focus device is being developed for this purpose, and there is a need for characterizing its electron beam, particularly, insofar as the energy spectrum is concerned. The instrument used is a magnetic spectrometer. To calibrate this spectrometer, a procedure relying on the energy-range relation in Mylar® has been devised and applied. By measuring the transmission through increasing thicknesses of the material, electron energies could be assessed and compared to the spectrometer readings. Thus, the original calibration of the instrument has been extended to higher energies and also to better accuracy. Methods and results are presented.

Bioforensics: Characterization of biological weapons agents by NanoSIMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, P K; Ghosal, S; Leighton, T J

2007-02-26

The anthrax attacks of Fall 2001 highlight the need to develop forensic methods based on multiple identifiers to determine the origin of biological weapons agents. Genetic typing methods (i.e., DNA and RNA-based) provide one attribution technology, but genetic information alone is not usually sufficient to determine the provenance of the material. Non-genetic identifiers, including elemental and isotopic signatures, provide complementary information that can be used to identify the means, geographic location and date of production. Under LDRD funding, we have successfully developed the techniques necessary to perform bioforensic characterization with the NanoSIMS at the individual spore level. We have developedmore » methods for elemental and isotopic characterization at the single spore scale. We have developed methods for analyzing spore sections to map elemental abundance within spores. We have developed rapid focused ion beam (FIB) sectioning techniques for spores to preserve elemental and structural integrity. And we have developed a high-resolution depth profiling method to characterize the elemental distribution in individual spores without sectioning. We used these newly developed methods to study the controls on elemental abundances in spores, characterize the elemental distribution of in spores, and to study elemental uptake by spores. Our work under this LDRD project attracted FBI and DHS funding for applied purposes.« less

ENVIRONMENTAL RESEARCH BRIEF: CHARACTERIZATION OF ORGANIC MATTER IN SOIL AND AQUIFER SOLIDS

EPA Science Inventory

The focus of this work was the evaluation of analytical methods to determine and characterize fractions of subsurface organic matter. Major fractions of total organic carbon (TOC) include: particulate organic carbon (POC) in aquifer material, dissolved organic carbon (DOC) and ...

Characterization of arterial traffic congestion through analysis of operational parameters (gap acceptance and lane changing).

DOT National Transportation Integrated Search

2010-05-01

This project monitored an urban arterial highway to characterize recurring congestion. There were two major initiatives in the project. The first one focused on observed variations in gap acceptance and lane changing in relation to traffic flow rates...

Material Stock Demographics: Cars in Great Britain.

PubMed

Cabrera Serrenho, André; Allwood, Julian M

2016-03-15

Recent literature on material flow analysis has been focused on quantitative characterization of past material flows. Fewer analyses exist on past and prospective quantification of stocks of materials in-use. Some of these analyses explore the composition of products' stocks, but a focus on the characterization of material stocks and its relation with service delivery is often neglected. We propose the use of the methods of human demography to characterize material stocks, defined herein as stock demographics, exploring the insights that this approach could provide for the sustainable management of materials. We exemplify an application of stock demographics by characterizing the composition and service delivery of iron, steel, and aluminum stocks of cars in Great Britain, 2002-2012. The results show that in this period the stock has become heavier, it is traveling less, and it is idle for more time. The visualization of material stocks' dynamics demonstrates the pace of product replacement as a function of its usefulness and enables the formulation of policy interventions and the exploration of future trends.

Analysis of in-service failures and advances in microstructural characterization. Microstructural science Volume 26

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abramovici, E.; Northwood, D.O.; Shehata, M.T.

1999-01-01

The contents include Analysis of In-Service Failures (tutorials, transportation industry, corrosion and materials degradation, electronic and advanced materials); 1998 Sorby Award Lecture by Kay Geels, Struers A/S (Metallographic Preparation from Sorby to the Present); Advances in Microstructural Characterization (characterization techniques using high resolution and focused ion beam, characterization of microstructural clustering and correlation with performance); Advanced Applications (advanced alloys and intermetallic compounds, plasma spray coatings and other surface coatings, corrosion, and materials degradation).

A study of the stress wave factor technique for evaluation of composite materials

NASA Technical Reports Server (NTRS)

Duke, J. C., Jr.; Henneke, E. G., II; Kiernan, M. T.; Grosskopf, P. P.

1989-01-01

The acousto-ultrasonic approach for nondestructive evaluation provides a measurement procedure for quantifying the integrated effect of globally distributed damage characteristic of fiber reinforced composite materials. The evaluation procedure provides a stress wave factor that correlates closely with several material performance parameters. The procedure was investigated for a variety of materials including advanced composites, hybrid structure bonds, adhesive bonds, wood products, and wire rope. The research program focused primarily on development of fundamental understanding and applications advancements of acousto-ultrasonics for materials characterization. This involves characterization of materials for which detection, location, and identification of imperfections cannot at present be analyzed satisfactorily with mechanical performance prediction models. In addition to presenting definitive studies on application potentials, the understanding of the acousto-ultrasonic method as applied to advanced composites is reviewed.

Critical differences between elective and emergency surgery: identifying domains for quality improvement in emergency general surgery.

PubMed

Columbus, Alexandra B; Morris, Megan A; Lilley, Elizabeth J; Harlow, Alyssa F; Haider, Adil H; Salim, Ali; Havens, Joaquim M

2018-04-01

The objective of our study was to characterize providers' impressions of factors contributing to disproportionate rates of morbidity and mortality in emergency general surgery to identify targets for care quality improvement. Emergency general surgery is characterized by a high-cost burden and disproportionate morbidity and mortality. Factors contributing to these observed disparities are not comprehensively understood and targets for quality improvement have not been formally developed. Using a grounded theory approach, emergency general surgery providers were recruited through purposive-criterion-based sampling to participate in semi-structured interviews and focus groups. Participants were asked to identify contributors to emergency general surgery outcomes, to define effective care for EGS patients, and to describe operating room team structure. Interviews were performed to thematic saturation. Transcripts were iteratively coded and analyzed within and across cases to identify emergent themes. Member checking was performed to establish credibility of the findings. A total of 40 participants from 5 academic hospitals participated in either individual interviews (n = 25 [9 anesthesia, 12 surgery, 4 nursing]) or focus groups (n = 2 [15 nursing]). Emergency general surgery was characterized by an exceptionally high level of variability, which can be subcategorized as patient-variability (acute physiology and comorbidities) and system-variability (operating room resources and workforce). Multidisciplinary communication is identified as a modifier to variability in emergency general surgery; however, nursing is often left out of early communication exchanges. Critical variability in emergency general surgery may impact outcomes. Patient-variability and system-variability, with focus on multidisciplinary communication, represent potential domains for quality improvement in this field. Copyright © 2017 Elsevier Inc. All rights reserved.

Development of Advanced Technologies for Complete Genomic and Proteomic Characterization of Quantized Human Tumor Cells

DTIC Science & Technology

2015-09-01

glioblastoma . We have successfully established several patient-derived cell lines from glioblastoma tumors and further established a number of...and single-cell technologies. Although the focus of this research is glioblastoma , the proposed tools are generally applicable to all cancer-based...studies. 15. SUBJECT TERMS Human cohorts, Glioblastoma , Genomic, Proteomic, Single-cell technologies, Hypothesis-driven, integrative systems approach

Affective Functioning among Early Adolescents at High and Low Familial Risk for Depression and Their Mothers: A Focus on Individual and Transactional Processes across Contexts

ERIC Educational Resources Information Center

McMakin, Dana L.; Burkhouse, Katie L.; Olino, Thomas M.; Siegle, Greg J.; Dahl, Ronald E.; Silk, Jennifer S.

2011-01-01

This study aimed to characterize affective functioning in families of youth at high familial risk for depression, with particular attention to features of affective functioning that appear to be critical to adaptive functioning but have been underrepresented in prior research including: positive "and" negative affect across multiple contexts,…

Novel biosynthesis of Ag-hydroxyapatite: Structural and spectroscopic characterization

NASA Astrophysics Data System (ADS)

Ruíz-Baltazar, Álvaro de Jesús; Reyes-López, Simón Yobanny; Silva-Holguin, Pamela Nair; Larrañaga, Daniel; Estévez, Miriam; Pérez, Ramiro

2018-06-01

Silver-doped hydroxyapatite (Ag-HAP) was obtained by green synthesis route. The dopant silver nanoparticles (AgNPs) were obtained by biosynthesis based on Melissa officinalis extract. This research is focused on the characterization and the use of the nontoxic and environment-friendly Ag-HAP nanocomposite. The structural and morphological characterization of Ag-HAP nanocomposite was carried out by scanning electron microscopy (SEM), X-ray diffraction, Fourier-transform infrared (FT-IR) and Raman spectroscopy. The obtained nanoparticles exhibited a great interaction with the HAP matrix, performing an Ag-HAP nanocomposite. Changes in the structure of the Ag-HAP nanocomposite were corroborated by the different characterization techniques. Additionally, a homogeneous distribution of the AgNPs on the HAP structure was observed. The heterogeneous nucleation process employed to doping the HAP, offer a functional route to obtain a green composite with potentials applications in multiple fields, such as tissue engineering, bone repair as well as protein. These properties can be evaluated in subsequent studies.

Advanced CD-SEM solution for edge placement error characterization of BEOL pitch 32nm metal layers

NASA Astrophysics Data System (ADS)

Charley, A.; Leray, P.; Lorusso, G.; Sutani, T.; Takemasa, Y.

2018-03-01

Metrology plays an important role in edge placement error (EPE) budgeting. Control for multi-patterning applications as new critical distances needs to be measured (edge to edge) and requirements become tighter and tighter in terms of accuracy and precision. In this paper we focus on imec iN7 BEOL platform and particularly on M2 patterning scheme using SAQP + block EUV for a 7.5 track logic design. Being able to characterize block to SAQP edge misplacement is important in a budgeting exercise (1) but is also extremely difficult due to challenging edge detection with CD-SEM (similar materials, thin layers, short distances, 3D features). In this study we develop an advanced solution to measure block to SAQP placement, we characterize it in terms of sensitivity, precision and accuracy through the comparison to reference metrology. In a second phase, the methodology is applied to budget local effects and the results are compared to the characterization of the SAQP and block independently.

Low-energy transmission electron diffraction and imaging of large-area graphene

PubMed Central

Zhao, Wei; Xia, Bingyu; Lin, Li; Xiao, Xiaoyang; Liu, Peng; Lin, Xiaoyang; Peng, Hailin; Zhu, Yuanmin; Yu, Rong; Lei, Peng; Wang, Jiangtao; Zhang, Lina; Xu, Yong; Zhao, Mingwen; Peng, Lianmao; Li, Qunqing; Duan, Wenhui; Liu, Zhongfan; Fan, Shoushan; Jiang, Kaili

2017-01-01

Two-dimensional (2D) materials have attracted interest because of their excellent properties and potential applications. A key step in realizing industrial applications is to synthesize wafer-scale single-crystal samples. Until now, single-crystal samples, such as graphene domains up to the centimeter scale, have been synthesized. However, a new challenge is to efficiently characterize large-area samples. Currently, the crystalline characterization of these samples still relies on selected-area electron diffraction (SAED) or low-energy electron diffraction (LEED), which is more suitable for characterizing very small local regions. This paper presents a highly efficient characterization technique that adopts a low-energy electrostatically focused electron gun and a super-aligned carbon nanotube (SACNT) film sample support. It allows rapid crystalline characterization of large-area graphene through a single photograph of a transmission-diffracted image at a large beam size. Additionally, the low-energy electron beam enables the observation of a unique diffraction pattern of adsorbates on the suspended graphene at room temperature. This work presents a simple and convenient method for characterizing the macroscopic structures of 2D materials, and the instrument we constructed allows the study of the weak interaction with 2D materials. PMID:28879233

Low-energy transmission electron diffraction and imaging of large-area graphene.

PubMed

Zhao, Wei; Xia, Bingyu; Lin, Li; Xiao, Xiaoyang; Liu, Peng; Lin, Xiaoyang; Peng, Hailin; Zhu, Yuanmin; Yu, Rong; Lei, Peng; Wang, Jiangtao; Zhang, Lina; Xu, Yong; Zhao, Mingwen; Peng, Lianmao; Li, Qunqing; Duan, Wenhui; Liu, Zhongfan; Fan, Shoushan; Jiang, Kaili

2017-09-01

Two-dimensional (2D) materials have attracted interest because of their excellent properties and potential applications. A key step in realizing industrial applications is to synthesize wafer-scale single-crystal samples. Until now, single-crystal samples, such as graphene domains up to the centimeter scale, have been synthesized. However, a new challenge is to efficiently characterize large-area samples. Currently, the crystalline characterization of these samples still relies on selected-area electron diffraction (SAED) or low-energy electron diffraction (LEED), which is more suitable for characterizing very small local regions. This paper presents a highly efficient characterization technique that adopts a low-energy electrostatically focused electron gun and a super-aligned carbon nanotube (SACNT) film sample support. It allows rapid crystalline characterization of large-area graphene through a single photograph of a transmission-diffracted image at a large beam size. Additionally, the low-energy electron beam enables the observation of a unique diffraction pattern of adsorbates on the suspended graphene at room temperature. This work presents a simple and convenient method for characterizing the macroscopic structures of 2D materials, and the instrument we constructed allows the study of the weak interaction with 2D materials.

Archaea in Natural and Impacted Brazilian Environments

PubMed Central

2016-01-01

In recent years, archaeal diversity surveys have received increasing attention. Brazil is a country known for its natural diversity and variety of biomes, which makes it an interesting sampling site for such studies. However, archaeal communities in natural and impacted Brazilian environments have only recently been investigated. In this review, based on a search on the PubMed database on the last week of April 2016, we present and discuss the results obtained in the 51 studies retrieved, focusing on archaeal communities in water, sediments, and soils of different Brazilian environments. We concluded that, in spite of its vast territory and biomes, the number of publications focusing on archaeal detection and/or characterization in Brazil is still incipient, indicating that these environments still represent a great potential to be explored. PMID:27829818

Mechanical Stability Study for Integrable Optics Test Accelerator at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGee, Mike; Andrews, Richard; Carlson, Kermit

2016-07-01

The Integrable Optics Test Accelerator (IOTA) is proposed for operation at Fermilab. The goal of IOTA is to create practical nonlinear accelerator focusing systems with a large frequency spread and stable particle motion. The IOTA is a 40 m circumference, 150 MeV (e-), 2.5 MeV (p⁺) diagnostic test ring. A heavy low frequency steel floor girder is proposed as the primary tier for IOTA device component support. Two design lengths; (8) 4 m and (2) 2.8 m long girders with identical cross section completely encompass the ring. This study focuses on the 4 m length girder and the development ofmore » a working prototype. Hydrostatic Level Sensor (HLS), temperature, metrology and fast motion measurements characterize the anticipated mechanical stability of the IOTA ring.« less

Hydrogen Purification Using Natural Zeolite Membranes

NASA Technical Reports Server (NTRS)

DelValle, William

2003-01-01

The School of Science at Universidad del Turabo (UT) have a long-lasting investigation plan to study the hydrogen cleaning and purification technologies. We proposed a research project for the synthesis, phase analysis and porosity characterization of zeolite based ceramic perm-selective membranes for hydrogen cleaning to support NASA's commitment to achieving a broad-based research capability focusing on aerospace-related issues. The present study will focus on technology transfer by utilizing inorganic membranes for production of ultra-clean hydrogen for application in combustion. We tested three different natural zeolite membranes (different particle size at different temperatures and time of exposure). Our results show that the membranes exposured at 900 C for 1Hr has the most higher permeation capacity, indicated that our zeolite membranes has the capacity to permeate hydrogen.

Consequences of Moral Distress in the Intensive Care Unit: A Qualitative Study.

PubMed

Henrich, Natalie J; Dodek, Peter M; Gladstone, Emilie; Alden, Lynn; Keenan, Sean P; Reynolds, Steven; Rodney, Patricia

2017-07-01

Moral distress is common among personnel in the intensive care unit, but the consequences of this distress are not well characterized. To examine the consequences of moral distress in personnel in community and tertiary intensive care units in Vancouver, Canada. Data for this study were obtained from focus groups and analysis of transcripts by themes and sub-themes in 2 tertiary care intensive care units and 1 community intensive care unit. According to input from 19 staff nurses (3 focus groups), 4 clinical nurse leaders (1 focus group), 13 physicians (3 focus groups), and 20 other health professionals (3 focus groups), the most commonly reported emotion associated with moral distress was frustration. Negative impact on patient care due to moral distress was reported 26 times, whereas positive impact on patient care was reported 11 times and no impact on patient care was reported 10 times. Having thoughts about quitting working in the ICU was reported 16 times, and having no thoughts about quitting was reported 14 times. In response to moral distress, health care providers experience negative emotional consequences, patient care is perceived to be negatively affected, and nurses and other health care professionals are prone to consider quitting working in the intensive care unit. ©2017 American Association of Critical-Care Nurses.

Emerging developments in the standardized chemical characterization of indoor air quality.

PubMed

Nehr, Sascha; Hösen, Elisabeth; Tanabe, Shin-Ichi

2017-01-01

Despite the fact that the special characteristics of indoor air pollution make closed environments quite different from outdoor environments, the conceptual ideas for assessing air quality indoors and outdoors are similar. Therefore, the elaboration of International Standards for air quality characterization in view of controlling indoor air quality should resort to this common basis. In this short review we describe the possibilities of standardization of tools dedicated to indoor air quality characterization with a focus on the tools permitting to study the indoor air chemistry. The link between indoor exposure and health as well as the critical processes driving the indoor air quality are introduced. Available International Standards for the assessment of indoor air quality are depicted. The standards comprise requirements for the sampling on site, the analytical procedures, and the determination of material emissions. To date, these standardized procedures assure that indoor air, settled dust and material samples are analyzed in a comparable manner. However, existing International Standards exclusively specify conventional, event-driven target-screening using discontinuous measurement methods for long-lived pollutants. Therefore, this review draws a parallel between physico-chemical processes in indoor and outdoor environments. The achievements in atmospheric sciences also improve our understanding of indoor environments. The community of atmospheric scientists can be both ideal and supporter for researchers in the area of indoor air quality characterization. This short review concludes with propositions for future standardization activities for the chemical characterization of indoor air quality. Future standardization efforts should focus on: (i) the elaboration of standardized measurement methods and measurement strategies for online monitoring of long-lived and short-lived pollutants, (ii) the assessment of the potential and the limitations of non-target screening, (iii) the paradigm shift from event-driven investigations to systematic approaches to characterize indoor environments, and (iv) the development of tools for policy implementation. Copyright © 2016 Elsevier Ltd. All rights reserved.

Anticipatory reward processing in addicted populations: a focus on the monetary incentive delay task.

PubMed

Balodis, Iris M; Potenza, Marc N

2015-03-01

Advances in brain imaging techniques have allowed neurobiological research to temporally analyze signals coding for the anticipation of reward. In addicted populations, both hyporesponsiveness and hyperresponsiveness of brain regions (e.g., ventral striatum) implicated in drug effects and reward system processing have been reported during anticipation of generalized reward. We discuss the current state of knowledge of reward processing in addictive disorders from a widely used and validated task: the monetary incentive delay task. Only studies applying the monetary incentive delay task in addicted and at-risk adult populations are reviewed, with a focus on anticipatory processing and striatal regions activated during task performance as well as the relationship of these regions with individual difference (e.g., impulsivity) and treatment outcome variables. We further review drug influences in challenge studies as a means to examine acute influences on reward processing in abstinent, recreationally using, and addicted populations. Generalized reward processing in addicted and at-risk populations is often characterized by divergent anticipatory signaling in the ventral striatum. Although methodologic and task variations may underlie some discrepant findings, anticipatory signaling in the ventral striatum may also be influenced by smoking status, drug metabolites, and treatment status in addicted populations. Divergent results across abstinent, recreationally using, and addicted populations demonstrate complexities in interpreting findings. Future studies would benefit from focusing on characterizing how impulsivity and other addiction-related features relate to anticipatory striatal signaling over time. Additionally, identifying how anticipatory signals recover or adjust after protracted abstinence will be important in understanding recovery processes. Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Experimental study of the response functions of direct-reading instruments measuring surface-area concentration of airborne nanostructured particles

NASA Astrophysics Data System (ADS)

Bau, Sébastien; Witschger, Olivier; Gensdarmes, François; Thomas, Dominique

2009-05-01

An increasing number of experimental and theoretical studies focus on airborne nanoparticles (NP) in relation with many aspects of risk assessment to move forward our understanding of the hazards, the actual exposures in the workplace, and the limits of engineering controls and personal protective equipment with regard to NP. As a consequence, generating airborne NP with controlled properties constitutes an important challenge. In parallel, toxicological studies have been carried out, and most of them support the concept that surface-area could be a relevant metric for characterizing exposure to airborne NP [1]. To provide NP surface-area concentration measurements, some direct-reading instruments have been designed, based on attachment rate of unipolar ions to NP by diffusion. However, very few information is available concerning the performances of these instruments and the parameters that could affect their responses. In this context, our work aims at characterizing the actual available instruments providing airborne NP surface-area concentration. The instruments (a- LQ1-DC, Matter Engineering; b-AeroTrak™ 9000, TSI; c- NSAM, TSI model 3550;) are thought to be relevant for further workplace exposure characterization and monitoring. To achieve our work, an experimental facility (named CAIMAN) was specially designed, built and characterized.

Fast and effective characterization of 3D region of interest in medical image data

NASA Astrophysics Data System (ADS)

Kontos, Despina; Megalooikonomou, Vasileios

2004-05-01

We propose a framework for detecting, characterizing and classifying spatial Regions of Interest (ROIs) in medical images, such as tumors and lesions in MRI or activation regions in fMRI. A necessary step prior to classification is efficient extraction of discriminative features. For this purpose, we apply a characterization technique especially designed for spatial ROIs. The main idea of this technique is to extract a k-dimensional feature vector using concentric spheres in 3D (or circles in 2D) radiating out of the ROI's center of mass. These vectors form characterization signatures that can be used to represent the initial ROIs. We focus on classifying fMRI ROIs obtained from a study that explores neuroanatomical correlates of semantic processing in Alzheimer's disease (AD). We detect a ROI highly associated with AD and apply the feature extraction technique with different experimental settings. We seek to distinguish control from patient samples. We study how classification can be performed using the extracted signatures as well as how different experimental parameters affect classification accuracy. The obtained classification accuracy ranged from 82% to 87% (based on the selected ROI) suggesting that the proposed classification framework can be potentially useful in supporting medical decision-making.

Synthesis, characterization and wound healing imitation of Fe3O4 magnetic nanoparticle grafted by natural products

NASA Astrophysics Data System (ADS)

Pala, Sravan Kumar

This research focused on the study of the core-shelled magnetic nanomaterials derived from a colloidal chemistry. The goals are four-fold: (1) synthesis of Fe3O4MNMs using colloidal chemistry. The Fe 3O4 MNMs were then grafted with extracts derived from natural products, namely Olecraceavar italica (broccoli), Boletus edulis (mushroom)and Solanum lycopersicum (tomato);(2)characterization of natural products by chromatography and mass spectrometry;(3) characterization of MNMs to determine their crystallinity, morphological and elemental composition by the state-of-the-art instruments; and (4) biological evaluation using Gram-negative and Gram-positive bacteria. The approach provides advantages to precisely control the composition and homogeneity. The second advantage of the colloidal chemistry is its user friendliness and feasibility. Due to the nature of the natural products, the compatibility of MNM is anticipated to be enhanced.In this chapter, the nanomaterials will be discussed from four perspectives,§1.1 Nanotechnology (§1.1), §1.2 Synthesis of nanomaterials; §1.3 The natural product extract,; §1.4 Characterization of nanomaterials; and §1.5Biological application of nanomaterials.Fig. 1 summarized the overarching goals of this study.

The effects of muscle hypotonia and weakness on balance: a study on Prader-Willi and Ehlers-Danlos syndrome patients.

PubMed

Galli, Manuela; Cimolin, Veronica; Vismara, Luca; Grugni, Graziano; Camerota, Filippo; Celletti, Claudia; Albertini, Giorgio; Rigoldi, Chiara; Capodaglio, Paolo

2011-01-01

Prader-Willi syndrome (PWS) and Ehlers-Danlos syndrome (EDS) are two different genetical disorders both characterized, among other features, by muscular hypotonia. Postural control seems to be impaired in both conditions. The aim of the present study was to quantitatively compare postural control in adult PWS and EDS using stabilometric platform to unveil possible common determinants of impaired balance. We enrolled 11 PWS and 21 EDS adult patients and 20 age-matched controls. They were instructed to maintain an upright standing position for 30s with open eyes (OEs) focusing on a 6 cm black circle positioned at a distance of 1.5m. Both PWS and EDS patients were characterized by higher RANGEML, RANGEAP and trajectory length of CoP values as compared to CG. No statistically differences were found between PWS and EDS in terms of any of these parameters. The results demonstrated that both PWS and EDS are characterized by a severe postural instability. Muscle hypotonia and weakness may account for reduced balance capacity. Quantitative characterization of instability is important to identify, develop and enhance rehabilitation interventions. Copyright © 2011 Elsevier Ltd. All rights reserved.

Characterization of Polymer Blends: Optical Microscopy (*Polarized, Interference and Phase Contrast Microscopy*) and Confocal Microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ramanathan, Nathan Muruganathan; Darling, Seth B.

2015-01-01

Chapter 15 surveys the characterization of macro, micro and meso morphologies of polymer blends by optical microscopy. Confocal Microscopy offers the ability to view the three dimensional morphology of polymer blends, popular in characterization of biological systems. Confocal microscopy uses point illumination and a spatial pinhole to eliminate out-of focus light in samples that are thicker than the focal plane.

Comparative Mineralogy, Microstructure and Compositional Trends in the Sub-Micron Size Fractions of Mare and Highland Lunar Soils

NASA Technical Reports Server (NTRS)

Thompson, M. S.; Christoffersen, R.; Noble, S. K.; Keller, L. P.

2012-01-01

The morphology, mineralogy, chemical composition and optical properties of lunar soils show distinct correlations as a function of grain size and origin [1,2,3]. In the <20 m size fraction, there is an increased correlation between lunar surface properties observed through remote sensing techniques and those attributed to space weathering phenomenae [1,2]. Despite the establishment of recognizable trends in lunar grains <20 in size [1,2,3], the size fraction < 10 m is characterized as a collective population of grains without subdivision. This investigation focuses specifically on grains in the <1 m diameter size fraction for both highland and mare derived soils. The properties of these materials provide the focus for many aspects of lunar research including the nature of space weathering on surface properties, electrostatic grain transport [4,5] and dusty plasmas [5]. In this study, we have used analytical transmission and scanning transmission electron microscopy (S/TEM) to characterize the mineralogy type, microstructure and major element compositions of grains in this important size range in lunar soils.

Numerical Characterization of a Composite Bonded Wing-Box

NASA Technical Reports Server (NTRS)

Smeltzer, Stanley S., III; Lovejoy, Andrew E.; Satyanarayana, Arunkumar

2008-01-01

The development of composite wing structures has focused on the use of mechanical fasteners to join heavily-loaded areas, while bonded joints have been used only for select locations. The focus of this paper is the examination of the adhesive layer in a generic bonded wing box that represents a "fastenerless" or unitized structure in order to characterize the general behavior and failure mechanisms. A global/local approach was applied to study the response of the adhesive layer using a global shell model and a local shell/solid model. The wing box was analyzed under load to represent a high-g up-bending condition such that the strains in the composite sandwich face sheets are comparable to an expected design allowable. The global/local analysis indicates that at these wing load levels the strains in the adhesive layer are well within the adhesive's elastic region, such that yielding would not be expected in the adhesive layer. The global/local methodology appears to be a promising approach to evaluate the structural integrity of the adhesively bonded structures.

Attentional Lapses in Attention-Deficit/Hyperactivity Disorder: Blank Rather Than Wandering Thoughts.

PubMed

Van den Driessche, Charlotte; Bastian, Mikaël; Peyre, Hugo; Stordeur, Coline; Acquaviva, Éric; Bahadori, Sara; Delorme, Richard; Sackur, Jérôme

2017-10-01

People with attention-deficit/hyperactivity disorder (ADHD) have difficulties sustaining their attention on external tasks. Such attentional lapses have often been characterized as the simple opposite of external sustained attention, but the different types of attentional lapses, and the subjective experiences to which they correspond, remain unspecified. In this study, we showed that unmedicated children (ages 6-12) with ADHD, when probed during a standard go/no-go task, reported more mind blanking (a mental state characterized by the absence of reportable content) than did control participants. This increase in mind blanking happened at the expense of both focused and wandering thoughts. We also found that methylphenidate reverted the level of mind blanking to baseline (i.e., the level of mind blanking reported by control children without ADHD). However, this restoration led to mind wandering more than to focused attention. In a second experiment, we extended these findings to adults who had subclinical ADHD. These results suggest that executive functions impaired in ADHD are required not only to sustain external attention but also to maintain an internal train of thought.

Community Perspectives on Factors That Influence Collaboration in Public Health Research

PubMed Central

Pinto, Rogério M.

2009-01-01

Community collaboration in research may lead to better methods, results, and dissemination of interventions. Little systematic research has examined specific factors that influence community-based organizations (CBOs) to collaborate in public health research. There is an urgent need to advance knowledge on this topic so that together, researchers and CBOs can minimize barriers to collaboration. This study advances a CBO-focused characterization of collaboration in HIV-prevention research. By focusing on the perspectives of 20 key informants in 10 HIV-prevention CBOs, qualitative data revealed factors that influenced their collaborations in four domains: (a) Researchers’ Characteristics (expertise, availability), (b) Collaborative Research Characteristics (ought to improve services and CBO infrastructure); (c) Community Partner–Researcher Relationships (resolving social and professional issues); and (d) Barriers to HIV-Prevention Research Collaboration (cultural and social disconnect between CBO and academia). To reduce barriers, researchers ought to enhance motivators that facilitate collaboration. To use the advantages of community-based research, prevention scientists and policy makers ought to embrace CBOs’ characterization of what makes health research genuinely collaborative. PMID:19196863

Synthesis and characterization of hematite pigment obtained from a steel waste industry.

PubMed

Prim, S R; Folgueras, M V; de Lima, M A; Hotza, D

2011-09-15

Pigments that meet environmental and technology requirements are the focus of the research in the ceramic sector. This study focuses on the synthesis of ceramic pigment by encapsulation of hematite in crystalline and amorphous silica matrix. Iron oxide from a metal sheet rolling process was used as chromophore. A different content of hematite and silica was homogenized by conventional and high energy milling. The powders obtained after calcinations between 1050 and 1200 °C for 2h were characterized by X-ray diffraction and SEM analysis. The pigments were applied to ceramic enamel and porcelain body. The effect of pigment was measured by comparing L*a*b* values of the heated samples. Results showed that the color developed is influenced by variables such as oxide content employed, conditions of milling and processing temperature. The results showed that the use of pigment developed does not interfere in microstructural characteristics of pigmented material. The best hue was obtained from samples with 15 wt% of chromophore, heated at 1200 °C in amorphous silica matrix. Copyright © 2011 Elsevier B.V. All rights reserved.

Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds

PubMed Central

Dhakal, Dipesh; Pokhrel, Anaya Raj; Shrestha, Biplav; Sohng, Jae Kyung

2017-01-01

Actinobacteria are prolific producers of thousands of biologically active natural compounds with diverse activities. More than half of these bioactive compounds have been isolated from members belonging to actinobacteria. Recently, rare actinobacteria existing at different environmental settings such as high altitudes, volcanic areas, and marine environment have attracted attention. It has been speculated that physiological or biochemical pressures under such harsh environmental conditions can lead to the production of diversified natural compounds. Hence, marine environment has been focused for the discovery of novel natural products with biological potency. Many novel and promising bioactive compounds with versatile medicinal, industrial, or agricultural uses have been isolated and characterized. The natural compounds cannot be directly used as drug or other purposes, so they are structurally modified and diversified to ameliorate their biological or chemical properties. Versatile synthetic biological tools, metabolic engineering techniques, and chemical synthesis platform can be used to assist such structural modification. This review summarizes the latest studies on marine rare actinobacteria and their natural products with focus on recent approaches for structural and functional diversification of such microbial chemicals for attaining better applications. PMID:28663748

Norwegian nursing and medical students’ perception of interprofessional teamwork: a qualitative study

PubMed Central

2014-01-01

Background Little is known about the ways in which nursing and medical students perceive and understand their roles in interprofessional teamwork. A 2010 report by the World Health Organization highlights the importance of students’ understanding of teamwork in healthcare, and their ability to be effective team players. This study aims at describing nursing and medical students’ perceptions of interprofessional teamwork, focusing on experiences and recommendations that can be used to guide future educational efforts. Methods The study uses a qualitative research design. Data were collected from four focus group interviews: two homogenous groups (one with medical students, one with nursing students) and two mixed groups (medical and nursing students). Results The results show that traditional patterns of professional role perception still prevail and strongly influence students’ professional attitudes about taking responsibility and sharing responsibility across disciplinary and professional boundaries. It was found that many students had experienced group cultures detrimental to team work. Focusing on clinical training, the study found a substantial variation in perception with regard to the different arenas for interprofessional teamwork, ranging from arenas with collaborative learning to arenas characterized by distrust, confrontation, disrespect and hierarchical structure. Conclusions This study underlines the importance of a stronger focus on interprofessional teamwork in health care education, particularly in clinical training. The study results suggest that the daily rounds and pre-visit “huddles,” or alternatively psychiatric wards, offer arenas suitable for interprofessional training, in keeping with the students’ assessments and criteria proposed in previous studies. PMID:25124090

Norwegian nursing and medical students' perception of interprofessional teamwork: a qualitative study.

PubMed

Aase, Ingunn; Hansen, Britt Sæthre; Aase, Karina

2014-08-14

Little is known about the ways in which nursing and medical students perceive and understand their roles in interprofessional teamwork. A 2010 report by the World Health Organization highlights the importance of students' understanding of teamwork in healthcare, and their ability to be effective team players. This study aims at describing nursing and medical students' perceptions of interprofessional teamwork, focusing on experiences and recommendations that can be used to guide future educational efforts. The study uses a qualitative research design. Data were collected from four focus group interviews: two homogenous groups (one with medical students, one with nursing students) and two mixed groups (medical and nursing students). The results show that traditional patterns of professional role perception still prevail and strongly influence students' professional attitudes about taking responsibility and sharing responsibility across disciplinary and professional boundaries. It was found that many students had experienced group cultures detrimental to team work. Focusing on clinical training, the study found a substantial variation in perception with regard to the different arenas for interprofessional teamwork, ranging from arenas with collaborative learning to arenas characterized by distrust, confrontation, disrespect and hierarchical structure. This study underlines the importance of a stronger focus on interprofessional teamwork in health care education, particularly in clinical training. The study results suggest that the daily rounds and pre-visit "huddles," or alternatively psychiatric wards, offer arenas suitable for interprofessional training, in keeping with the students' assessments and criteria proposed in previous studies.

Effect of Background Pressure on the Plasma Oscillation Characteristics of the HiVHAc Hall Thruster

DTIC Science & Technology

2014-06-01

Hall thruster , a number of plasma diagnostics were implemented to study the effect of varying facility background pressure on thruster operation. These diagnostics characterized the thruster performance, the plume, and the plasma oscillations in the thruster. Thruster performance and plume characteristics as functions of background pressure were previously published. This paper will focus on changes in the plasma oscillation characteristics with changing background pressure. The diagnostics used to study plasma oscillations include a high-speed camera and a set of

Mediating and Moderating Effects in Ageism and Depression among the Korean Elderly: The Roles of Emotional Reactions and Coping Reponses

PubMed Central

Kim, Il-Ho; Noh, Samuel; Chun, Heeran

2015-01-01

Objectives This study evaluated the relationship between ageism and depression, exploring the stress-mediating and stress-moderating roles of emotional reactions and coping behaviors. Methods Data were from the 2013 Ageism and Health Study (n = 816), a cross-sectional survey of urban and rural community-dwelling seniors aged 60–89 years in South Korea. Participants with at least one experience of ageism reported on their emotional reactions and coping responses. The measure yielded two types of coping: problem-focused (taking formal action, confrontation, seeking social support) and emotion-focused (passive acceptance, emotional discharge). Results Although ageism was significantly associated with depressive symptoms (B = 0.27, p < 0.0001), the association was entirely mediated by emotional reactions such as anger, sadness, and powerlessness. Problem-focused coping, especially confrontation and social support, seemingly reduced the impact of emotional reactions on depression, whereas emotion-focused coping exacerbated the adverse effects. Conclusion These findings support the cultural characterization explanation of ageism and related coping processes among Korean elderly and suggest that regulating emotional reactions may determine the efficacy of coping with ageism. PMID:26981336

Distributed Soil Moisture Estimation in a Mountainous Semiarid Basin: Constraining Soil Parameter Uncertainty through Field Studies

NASA Astrophysics Data System (ADS)

Yatheendradas, S.; Vivoni, E.

2007-12-01

A common practice in distributed hydrological modeling is to assign soil hydraulic properties based on coarse textural datasets. For semiarid regions with poor soil information, the performance of a model can be severely constrained due to the high model sensitivity to near-surface soil characteristics. Neglecting the uncertainty in soil hydraulic properties, their spatial variation and their naturally-occurring horizonation can potentially affect the modeled hydrological response. In this study, we investigate such effects using the TIN-based Real-time Integrated Basin Simulator (tRIBS) applied to the mid-sized (100 km2) Sierra Los Locos watershed in northern Sonora, Mexico. The Sierra Los Locos basin is characterized by complex mountainous terrain leading to topographic organization of soil characteristics and ecosystem distributions. We focus on simulations during the 2004 North American Monsoon Experiment (NAME) when intensive soil moisture measurements and aircraft- based soil moisture retrievals are available in the basin. Our experiments focus on soil moisture comparisons at the point, topographic transect and basin scales using a range of different soil characterizations. We compare the distributed soil moisture estimates obtained using (1) a deterministic simulation based on soil texture from coarse soil maps, (2) a set of ensemble simulations that capture soil parameter uncertainty and their spatial distribution, and (3) a set of simulations that conditions the ensemble on recent soil profile measurements. Uncertainties considered in near-surface soil characterization provide insights into their influence on the modeled uncertainty, into the value of soil profile observations, and into effective use of on-going field observations for constraining the soil moisture response uncertainty.

Assessing poisoning risks related to storage of household hazardous materials: using a focus group to improve a survey questionnaire.

PubMed

Kaufman, Martin M; Smolinske, Susan; Keswick, David

2005-08-10

In fall of 2004, the authors began an investigation to characterize the correlations between the storage of Household Hazardous Materials and the associated health risks, particularly to children. The study area selected was Genesee County, Michigan, near Flint, with data to be collected by a phone survey of residents and through the acquisition of county hospital records containing procedure codes indicating treatment for poison emergencies, and review of poison control center data. A focus group was used to identify key topics and relationships within these data for improving the phone survey questionnaire and its analysis. The focus group was successful in identifying the key issues with respect to all the data collection objectives, resulting in a significantly shorter and more topically focused survey questionnaire. Execution time of the phone survey decreased from 30 to 12 minutes, and useful relationships between the data were revealed, e.g., the linkage between reading food labels and reading labels on containers containing potentially harmful substances. Focus groups and their preparatory planning can help reveal data interrelationships before larger surveys are undertaken. Even where time and budget constraints prevent the ability to conduct a series of focus groups, one successful focus group session can improve survey performance and reduce costs.

Strategies Identified as Effective by Mothers During Occupational Performance Coaching.

PubMed

Graham, Fiona; Rodger, Sylvia; Ziviani, Jenny; Jones, Virginia

2016-08-01

This study examined strategies mothers reported as effective in facilitating children's successful performance in activities they identified as goals during Occupational Performance Coaching (OPC). Twenty-nine mothers of children with occupational performance issues engaged in OPC. A random sample of 44 /157 (28%) coaching sessions were video-recorded from which the audio recording was analyzed using a general inductive approach to explore the nature of strategies reported as effective by mothers. Two major themes emerged: (1) Context-focused; or (2) Child-focused. Context-focused strategies were characterized by mothers' actions that made the performance context more conducive to children's success. The emphasis of mothers' intention in Context-focused strategies was achievement of the task with minimal stress. Context-focused strategies included subthemes of Adjust Manner, Create Distance, Add Structure and Routine, and Teach. Child-focused strategies required higher levels of engagement with children in the application of strategies and were focused on children's skill development. Subthemes included Collaboration and Offer Choice. Mothers engaged in coaching identified strategies which they found supported children's performance, attesting to the existing capacity of mothers in identifying and evaluating effective ways of enhancing children's performance. Findings suggest the potential of coaching as a capacity-building, context-based intervention to improve children's performance.

Elaboration and characterization of metallurgical silicon for photovoltaic applications

NASA Astrophysics Data System (ADS)

Barbouche, M.; Hajji, M.; Krout, F.; Ezzaouia, H.

2015-04-01

There is a small quantity of participants in the global market of silicon, mainly from the developed countries. It should be noticed also that production of metallurgical silicon Mg-Si is among the most important steps to produce solar grade silicon and photovoltaic panels. Therefore, in this paper we focused on the growth of Mg-Si by carbothermal reduction of silica. An investigation was made using FT-IR characterization to study the effect of process conditions (temperature, atmosphere, duration) in Mg-Si production. Raman spectroscopy was used to investigate the produced Mg-Si. Based on these results, we established a pilot line production of metallurgical silicon at the "CRTEn" in Tunisia.

Explosively produced fracture of oil shale

NASA Astrophysics Data System (ADS)

Morris, W. A.

1982-05-01

Rock fragmentation research in oil shale to develop the blasting technologies and designs required to prepare a rubble bed for a modified in situ retort is reported. Experimental work is outlined, proposed studies in explosive characterization are detailed and progress in numerical calculation techniques to predict fracture of the shale is described. A detailed geologic characterization of two Anvil Points experiment sites is related to previous work at Colony Mine. The second section focuses on computer modeling and theory. The latest generation of the stress wave code SHALE, its three dimensional potential, and the slide line package for it are described. A general stress rate equation that takes energy dependence into account is discussed.

Characterization of Localized Filament Corrosion Products at the Anodic Head on a Model Mg-Zn-Zr Alloy Surface

DOE PAGES

Rossouw, David; Fu, Dong; Leonard, Donovan N.; ...

2017-02-15

In this study, localized filament corrosion products at the anodic head on a model Mg-1%Zn-0.4%Zr alloy surface were characterized by electron microscopy techniques of site-specific lamella prepared by focused ion beam milling. It is revealed that the anodic head propagates underneath a largely intact thin and dense MgO surface film and comprises dense aggregates of nano-crystalline MgO within a nano-porous Mg(OH) 2 network. In conclusion, the findings contribute new supportive direct imaging insight into the source of the enhanced H 2 evolution that accompanies anodic dissolution of Mg and its alloys.

Indentation-Enabled In Situ Mechanical Characterization of Micro/Nanopillars in Electron Microscopes

NASA Astrophysics Data System (ADS)

Guo, Qiang; Fu, Xidan; Guo, Xiaolei; Liu, Zhiying; Shi, Yan; Zhang, Di

2018-04-01

Indentation-enabled micro/nanomechanical characterization of small-scale specimens provides powerful new tools for probing materials properties that were once unattainable by conventional experimental methods. Recent advancement in instrumentation further allows mechanical testing to be carried out in situ in electron microscopes, with high spatial and temporal resolution. This review discusses the recent development of nanoindentation-enabled in situ mechanical testing in electron microscopes, with an emphasis on the study of micro/nanopillars. Focus is given to novel applications beyond simple compressive and tensile testing that have been developed in the past few years, and limitations and possible future research directions in this field are proposed and discussed.

Characterization of Localized Filament Corrosion Products at the Anodic Head on a Model Mg-Zn-Zr Alloy Surface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rossouw, David; Fu, Dong; Leonard, Donovan N.

In this study, localized filament corrosion products at the anodic head on a model Mg-1%Zn-0.4%Zr alloy surface were characterized by electron microscopy techniques of site-specific lamella prepared by focused ion beam milling. It is revealed that the anodic head propagates underneath a largely intact thin and dense MgO surface film and comprises dense aggregates of nano-crystalline MgO within a nano-porous Mg(OH) 2 network. In conclusion, the findings contribute new supportive direct imaging insight into the source of the enhanced H 2 evolution that accompanies anodic dissolution of Mg and its alloys.

Characterization of quantum interference control of injected currents in LT-GaAs for carrier-envelope phase measurements.

PubMed

Roos, Peter; Quraishi, Qudsia; Cundiff, Steven; Bhat, Ravi; Sipe, J

2003-08-25

We use two mutually coherent, harmonically related pulse trains to experimentally characterize quantum interference control (QIC) of injected currents in low-temperature-grown gallium arsenide. We observe real-time QIC interference fringes, optimize the QIC signal fidelity, uncover critical signal dependences regarding beam spatial position on the sample, measure signal dependences on the fundamental and second harmonic average optical powers, and demonstrate signal characteristics that depend on the focused beam spot sizes. Following directly from our motivation for this study, we propose an initial experiment to measure and ultimately control the carrier-envelope phase evolution of a single octave-spanning pulse train using the QIC phenomenon.

Synthesis and characterization of colloidal ZnTe nanocrystals and ZnTe/ZnSe quantum dots

NASA Astrophysics Data System (ADS)

Gonzales, Gavin P.; Alas, Gema; Senthil, Arjun; Withers, Nathan J.; Minetos, Christina; Sandoval, Alejandro; Ivanov, Sergei A.; Smolyakov, Gennady A.; Huber, Dale L.; Osiński, Marek

2018-02-01

Quantum dots (QDs) emitting in the visible are of interest for many biomedical applications, including bioimaging, biosensing, drug targeting, and photodynamic therapy. However, a significant limitation is that QDs typically contain cadmium, which makes prospects for their FDA approval very unlikely. Previous work has focused on InP and ZnO as alternative semiconductor materials for QDs. However, these nanoparticles have also been shown to be cytotoxic. High-efficiency luminescent ZnTe-based QDs could be a reasonable alternative to Cd-containing QDs. In this paper, we present preliminary results of our recent studies of ZnTe-based QDs, including their synthesis, structural characterization, and optical properties.

Addiction research centres and the nurturing of creativity. University of Michigan Addiction Research Center (UMARC): development, evolution, and direction.

PubMed

Zucker, Robert A

2010-06-01

A historical summary is provided of the evolution of the University of Michigan Addiction Research Center (UMARC) since its origins in 1988. Begun as an National Institutes of Health (NIH) research center within a Department of Psychiatry and focused solely upon alcohol and aging, early work emphasized treatment efficacy, differential outcome studies and characterization of the neurophysiological and behavioral manifestations of chronic alcoholism. Over the last 15 years, UMARC has extended its research focus along a number of dimensions: its developmental reach has been extended etiologically by studies of risk early in the life span, and by way of work on earlier screening and the development of early, brief treatment interventions. The addiction focus has expanded to include other drugs of abuse. Levels of analysis have also broadened, with work on the molecular genetics and brain neurophysiology underlying addictive processes, on one hand, and examination of the role of the social environment in long-term course of disorder on the other hand. Activities have been facilitated by several research training programs and by collaborative relationships with other universities around the United States and in Poland. Since 2002, a program for research infrastructure development and collaboration has been ongoing, initially with Poland and more recently with Ukraine, Latvia and Slovakia. A blueprint for the future includes expanded characterization of the neurobiology and genetics of addictive processes, the developmental environment, as well as programmatic work to address the public health implications of our ability to identify risk for disorder very early in life.

Addiction research centres and the nurturing of creativity: University of Michigan Addiction Research Center (UMARC): Development, Evolution, and Direction

PubMed Central

Zucker, Robert A.

2010-01-01

A historical summary is provided of the evolution of the University of Michigan Addiction Research Center (UMARC) since its origins in 1988. Begun as an NIH research center within a Department of Psychiatry and focused solely on alcohol and aging, early work emphasized treatment efficacy, differential outcome studies, and characterization of the neurophysiological and behavioral manifestations of chronic alcoholism. Over the last fifteen years, UMARC has extended its research focus along a number of dimensions: Its developmental reach has been extended etiologically by studies of risk early in the life span, and by way of work on earlier screening and the development of early, brief treatment interventions. The addiction focus has expanded to include other drugs of abuse. Levels of analysis have also broadened, with work on the molecular genetics and brain neurophysiology underlying addictive processes on the one hand, and examination of the role of the social environment in long term course of disorder on the other. Activities have been facilitated by several research training programs and by collaborative relationships with other universities around the United States and in Poland. Since 2002, a program for research infrastructure development and collaboration has been carried on, initially with Poland and more recently with Ukraine, Latvia, and Slovakia. A blueprint for the future includes expanded characterization of the neurobiology and genetics of addictive processes, the developmental environment, as well as programmatic work to address the public health implications of our ability to identify risk for disorder very early in life. PMID:20331547

Being a pedestrian with dementia: A qualitative study using photo documentation and focus group interviews.

PubMed

Brorsson, Anna; Öhman, Annika; Lundberg, Stefan; Nygård, Louise

2016-09-01

The aim of the study was to identify problematic situations in using zebra crossings. They were identified from photo documentations comprising film sequences and the perspectives of people with dementia. The aim was also to identify how they would understand, interpret and act in these problematic situations based on their previous experiences and linked to the film sequences.A qualitative grounded theory approach was used. Film sequences from five zebra crossings were analysed. The same film sequences were used as triggers in two focus group interviews with persons with dementia. Individual interviews with three informants were also performed.The core category, the hazard of meeting unfolding problematic traffic situations when only one layer at a time can be kept in focus, showed how a problematic situation as a whole consisted of different layers of problematic situations. The first category, adding layers of problematic traffic situations to each other, was characterized by the informants' creation of a problematic situation as a whole. The different layers were described in the subcategories of layout of streets and zebra crossings, weather conditions, vehicles and crowding of pedestrians. The second category, actions used to meet different layers of problematic traffic situations, was characterized by avoiding problematic situations, using traffic lights as reminders and security precautions, following the flow at the zebra crossing and being cautious pedestrians.In conclusion, as community-dwelling people with dementia commonly are pedestrians, it is important that health care professionals and caregivers take their experiences and management of problematic traffic situations into account when providing support. © The Author(s) 2014.

Large scale Tesla coil guided discharges initiated by femtosecond laser filamentation in air

NASA Astrophysics Data System (ADS)

Arantchouk, L.; Point, G.; Brelet, Y.; Prade, B.; Carbonnel, J.; André, Y.-B.; Mysyrowicz, A.; Houard, A.

2014-07-01

The guiding of meter scale electric discharges produced in air by a Tesla coil is realized in laboratory using a focused terawatt laser pulse undergoing filamentation. The influence of the focus position, the laser arrival time, or the gap length is studied to determine the best conditions for efficient laser guiding. Discharge parameters such as delay, jitter, and resistance are characterized. An increase of the discharge length by a factor 5 has been achieved with the laser filaments, corresponding to a mean breakdown field of 2 kV/cm for a 1.8 m gap length. Consecutive guided discharges at a repetition rate of 10 Hz are also reported.

ALICE results from Run-1 and Run-2 and perspectives for Run-3 and Run-4

NASA Astrophysics Data System (ADS)

Noferini, Francesco; ALICE Collaboration

2018-05-01

A review of ALICE is presented focusing on its physics programme and results from the Run-1 and Run-2 data taking periods. Among the four major LHC experiments, ALICE is devoted to the study of the Quark-Gluon Plasma produced in ultra-relativistic heavy-ion collisions (Pb–Pb), but it is also collecting data in smaller systems (pp and p–Pb). This review focuses on the main results collected so far, including the characterization of the QGP via soft and hard probes, and the production rate of light nuclei and hypernuclei. Finally, the perspectives after the detectors upgrades to be performed during 2019-2020 are presented.

Application of biocompatible magnetite nanoparticles for the removal of arsenic and copper from water

NASA Astrophysics Data System (ADS)

Iconaru, S. L.; Beuran, M.; Turculet, C. S.; Negoi, I.; Teleanu, G.; Prodan, A. M.; Motelica-Heino, M.; Guégan, R.; Ciobanu, C. S.; Jiga, G.; Predoi, Daniela

2018-02-01

The progress of nanotechnology made possible the use of nanomaterials as adsorbents and magnetic iron oxides represents one of the first generations of nanoscale materials used in environment technologies [1]. A systematic characterization of commercial magnetite (Fe3O4) is presented in this research. The commercial (Fe3O4) magnetic adsorbents were characterized by various characterizations methods such as X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray analysis (EDX). This study was also focused on the study of adsorption isotherms and the kinetics evaluation. X-ray studies indicated that As3+ and Cu2+ removed by Fe3O4 did not seem to alter the structure of Fe3O4 but they were highlighted in the EDX analysis. In addition, the SEM studies were consistent with the XRD results. The rate of adsorption of contaminants, in contaminated solutions decreases when the amount of contaminant increases in all experiments performed. The results revealed that Fe3O4 nanoparticles are promising candidates which could be used as sorbents for the removal of arsenic from the marine environment, for site remediation and groundwater treatment.

Identification and immunophenotypic characterization of normal and pathological mast cells.

PubMed

Morgado, José Mário; Sánchez-Muñoz, Laura; Teodósio, Cristina; Escribano, Luís

2014-01-01

Mast cells (MCs) are secretory cells that are central players in human allergic disease and immune responses. With the exception of a few pathological situations, MCs are usually present at relatively low frequencies in most tissues. Since their first description, MCs in tissues were identified mostly using their morphological characteristics and their typical coloration when stained with aniline dyes. However, increasing availability of highly specific antibodies now permits the use of fluorescence-based flow cytometry as the method of choice for the quantification, characterization, and purification of cells in suspension. This technique allows for a rapid analysis of thousands of events and for the identification of cells present at frequencies as low as one event in 10(6) unwanted cells. This method also permits for simultaneous characterization of multiple antigens at a single-cell level, which is ideal in order to study rare populations of cells like MCs. Here we describe the basis of flow cytometry-based immunophenotyping applied to the study of MC. The protocol focuses on the study of human MCs present in body fluids (mainly bone marrow) but can easily be adapted to study MCs from other tissues and species.

Biophysics of α-synuclein membrane interactions.

PubMed

Pfefferkorn, Candace M; Jiang, Zhiping; Lee, Jennifer C

2012-02-01

Membrane proteins participate in nearly all cellular processes; however, because of experimental limitations, their characterization lags far behind that of soluble proteins. Peripheral membrane proteins are particularly challenging to study because of their inherent propensity to adopt multiple and/or transient conformations in solution and upon membrane association. In this review, we summarize useful biophysical techniques for the study of peripheral membrane proteins and their application in the characterization of the membrane interactions of the natively unfolded and Parkinson's disease (PD) related protein, α-synuclein (α-syn). We give particular focus to studies that have led to the current understanding of membrane-bound α-syn structure and the elucidation of specific membrane properties that affect α-syn-membrane binding. Finally, we discuss biophysical evidence supporting a key role for membranes and α-syn in PD pathogenesis. This article is part of a Special Issue entitled: Membrane protein structure and function. Copyright © 2011. Published by Elsevier B.V.

Influences of Geomorphic Complexity and Rehabilitation on Nutrient Uptake in an Urban Stream

NASA Astrophysics Data System (ADS)

Mueller, J. S.; Baker, D. W.; Bledsoe, B. P.

2006-12-01

Headwater streams, which are highly vulnerable to anthropogenic impacts associated with land use change, have large surface-to-volume ratios that favor retention and removal of nitrogen. We describe a study focused on how geomorphic complexity is related to nutrient retention in impacted and restored headwater streams along a gradient of human land use. A key element of the study is a detailed protocol for characterizing the spatial distribution of physical habitat units composed of relatively distinct combinations of flow hydraulics and textural facies. We are using the detailed physical characterization and nutrient injections in paired segments of a Colorado Front Range urban stream to examine associations among geomorphic complexity, nitrogen uptake, and the degree and style of channel rehabilitation. The results of the study have implications for the viability of stream rehabilitation as a tool for reducing N delivery to downstream aquatic systems that are vulnerable to eutrophication.

Characterization of an In-Situ Ground Terminal via a Geostationary Satellite

NASA Technical Reports Server (NTRS)

Piasecki, Marie T.; Welch, Bryan W.; Mueller, Carl H.

2015-01-01

In 2015, the Space Communications and Navigation (SCaN) Testbed project completed an S-Band ground station located at the NASA Glenn Research Center in Cleveland, Ohio. This S-Band ground station was developed to create a fully characterized and controllable dynamic link environment when testing novel communication techniques for Software Defined Radios and Cognitive Communication Systems. In order to provide a useful environment for potential experimenters, it was necessary to characterize various RF devices at both the component level in the laboratory and at the system level after integration. This paper will discuss some of the laboratory testing of the ground station components, with a particular focus/emphasis on the near-field measurements of the antenna. It will then describe the methodology for characterizing the installed ground station at the system level via a Tracking and Data Relay Satellite (TDRS), with specific focus given to the characterization of the ground station antenna pattern, where the max TDRS transmit power limited the validity of the non-noise floor received power data to the antenna main lobe region. Finally, the paper compares the results of each test as well as provides lessons learned from this type of testing methodology.

Characterization of an In-Situ Ground Terminal via a Geostationary Satellite

NASA Technical Reports Server (NTRS)

Piasecki, Marie; Welch, Bryan; Mueller, Carl

2015-01-01

In 2015, the Space Communications and Navigation (SCaN) Testbed project completed an S-Band ground station located at the NASA Glenn Research Center in Cleveland, Ohio. This S-Band ground station was developed to create a fully characterized and controllable dynamic link environment when testing novel communication techniques for Software Defined Radios and Cognitive Communication Systems. In order to provide a useful environment for potential experimenters, it was necessary to characterize various RF devices at both the component level in the laboratory and at the system level after integration. This paper will discuss some of the laboratory testing of the ground station components, with a particular focus emphasis on the near-field measurements of the antenna. It will then describe the methodology for characterizing the installed ground station at the system level via a Tracking and Data Relay Satellite (TDRS), with specific focus given to the characterization of the ground station antenna pattern, where the max TDRS transmit power limited the validity of the non-noise floor received power data to the antenna main lobe region. Finally, the paper compares the results of each test as well as provides lessons learned from this type of testing methodology.

A Qualitative Assessment of Weight Control among Rural Kansas Women

ERIC Educational Resources Information Center

Ely, Andrea C.; Befort, Christie; Banitt, Angela; Gibson, Cheryl; Sullivan, Debra

2009-01-01

Objective: To explore weight control beliefs, attitudes, knowledge, and practices among rural Kansas women, and to characterize the relationship of these women with their primary-care providers around weight control. Design: Qualitative research using focus groups. Setting: Three separate communities of rural Kansas. Participants: Six focus groups…

Benefits of utilizing CellProfiler as a characterization tool for U-10Mo nuclear fuel

DOE PAGES

Collette, R.; Douglas, J.; Patterson, L.; ...

2015-05-01

Automated image processing techniques have the potential to aid in the performance evaluation of nuclear fuels by eliminating judgment calls that may vary from person-to-person or sample-to-sample. Analysis of in-core fuel performance is required for design and safety evaluations related to almost every aspect of the nuclear fuel cycle. This study presents a methodology for assessing the quality of uranium-molybdenum fuel images and describes image analysis routines designed for the characterization of several important microstructural properties. The analyses are performed in CellProfiler, an open-source program designed to enable biologists without training in computer vision or programming to automatically extract cellularmore » measurements from large image sets. The quality metric scores an image based on three parameters: the illumination gradient across the image, the overall focus of the image, and the fraction of the image that contains scratches. The metric presents the user with the ability to ‘pass’ or ‘fail’ an image based on a reproducible quality score. Passable images may then be characterized through a separate CellProfiler pipeline, which enlists a variety of common image analysis techniques. The results demonstrate the ability to reliably pass or fail images based on the illumination, focus, and scratch fraction of the image, followed by automatic extraction of morphological data with respect to fission gas voids, interaction layers, and grain boundaries.« less

The Quality of Rare Disease Registries: Evaluation and Characterization.

PubMed

Coi, Alessio; Santoro, Michele; Villaverde-Hueso, Ana; Lipucci Di Paola, Michele; Gainotti, Sabina; Taruscio, Domenica; Posada de la Paz, Manuel; Bianchi, Fabrizio

2016-01-01

The focus on the quality of the procedures for data collection, storing, and analysis in the definition and implementation of a rare disease registry (RDR) is the basis for developing a valid and long-term sustainable tool. The aim of this study was to provide useful information for characterizing a quality profile for RDRs using an analytical approach applied to RDRs participating in the European Platform for Rare Disease Registries 2011-2014 (EPIRARE) survey. An indicator of quality was defined by choosing a small set of quality-related variables derived from the survey. The random forest method was used to identify the variables best defining a quality profile for RDRs. Fisher's exact test was employed to assess the association with the indicator of quality, and the Cochran-Armitage test was used to check the presence of a linear trend along different levels of quality. The set of variables found to characterize high-quality RDRs focused on ethical and legal issues, governance, communication of activities and results, established procedures to regulate access to data and security, and established plans to ensure long-term sustainability. The quality of RDRs is usually associated with a good oversight and governance mechanism and with durable funding. The results suggest that RDRs would benefit from support in management, information technology, epidemiology, and statistics. © 2016 S. Karger AG, Basel.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.

In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET),more » functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.« less

Promotion and Prevention Focused Feeding Strategies: Exploring the Effects on Healthy and Unhealthy Child Eating.

PubMed

Melbye, Elisabeth L; Hansen, Håvard

2015-01-01

There is a general lack of research addressing the motivations behind parental use of various feeding practices. Therefore, the present work aims to extend the current literature on parent-child feeding interactions by integrating the traditional developmental psychological perspective on feeding practices with elements of Regulatory Focus Theory (RFT) derived from the field of motivational psychology. In this paper, we seek to explain associations between parental feeding practices and child (un)healthy eating behaviors by categorizing parental feeding practices into promotion and prevention focused strategies, thus exploring parent-child feeding interactions within the framework of RFT. Our analyses partly supported the idea that (1) child healthy eating is positively associated with feeding practices characterized as promotion focused, and (2) child unhealthy eating is negatively associated with feeding practices characterized as prevention focused. However, a general observation following from our results suggests that parents' major driving forces behind reducing children's consumption of unhealthy food items and increasing their consumption of healthy food items are strategies that motivate rather than restrict. In particular, parents' provision of a healthy home food environment seems to be essential for child eating.

Promotion and Prevention Focused Feeding Strategies: Exploring the Effects on Healthy and Unhealthy Child Eating

PubMed Central

Melbye, Elisabeth L.; Hansen, Håvard

2015-01-01

There is a general lack of research addressing the motivations behind parental use of various feeding practices. Therefore, the present work aims to extend the current literature on parent-child feeding interactions by integrating the traditional developmental psychological perspective on feeding practices with elements of Regulatory Focus Theory (RFT) derived from the field of motivational psychology. In this paper, we seek to explain associations between parental feeding practices and child (un)healthy eating behaviors by categorizing parental feeding practices into promotion and prevention focused strategies, thus exploring parent-child feeding interactions within the framework of RFT. Our analyses partly supported the idea that (1) child healthy eating is positively associated with feeding practices characterized as promotion focused, and (2) child unhealthy eating is negatively associated with feeding practices characterized as prevention focused. However, a general observation following from our results suggests that parents' major driving forces behind reducing children's consumption of unhealthy food items and increasing their consumption of healthy food items are strategies that motivate rather than restrict. In particular, parents' provision of a healthy home food environment seems to be essential for child eating. PMID:26380269

Highly accurate apparatus for electrochemical characterization of the felt electrodes used in redox flow batteries

NASA Astrophysics Data System (ADS)

Park, Jong Ho; Park, Jung Jin; Park, O. Ok; Jin, Chang-Soo; Yang, Jung Hoon

2016-04-01

Because of the rise in renewable energy use, the redox flow battery (RFB) has attracted extensive attention as an energy storage system. Thus, many studies have focused on improving the performance of the felt electrodes used in RFBs. However, existing analysis cells are unsuitable for characterizing felt electrodes because of their complex 3-dimensional structure. Analysis is also greatly affected by the measurement conditions, viz. compression ratio, contact area, and contact strength between the felt and current collector. To address the growing need for practical analytical apparatus, we report a new analysis cell for accurate electrochemical characterization of felt electrodes under various conditions, and compare it with previous ones. In this cell, the measurement conditions can be exhaustively controlled with a compression supporter. The cell showed excellent reproducibility in cyclic voltammetry analysis and the results agreed well with actual RFB charge-discharge performance.

Determination of parameters used to prevent ignition of stored materials and to protect against explosions in food industries.

PubMed

Ramírez, Alvaro; García-Torrent, Javier; Aguado, Pedro J

2009-08-30

There are always risks associated with silos when the stored material has been characterized as prone to self-ignition or explosion. Further research focused on the characterization of agricultural materials stored in silos is needed due to the lack of data found in the literature. The aim of this study was to determine the ignitability and explosive parameters of several agricultural products commonly stored in silos in order to assess the risk of ignition and dust explosion. Minimum Ignition Temperature, with dust forming a cloud and deposited in a layer, Lower Explosive Limit, Minimum Ignition Energy, Maximum Explosion Pressure and Maximum Explosion Pressure Rise were determined for seven agricultural materials: icing sugar, maize, wheat and barley grain dust, alfalfa, bread-making wheat and soybean dust. Following characterization, these were found to be prone to producing self-ignition when stored in silos under certain conditions.

Alu repeat discovery and characterization within human genomes

PubMed Central

Hormozdiari, Fereydoun; Alkan, Can; Ventura, Mario; Hajirasouliha, Iman; Malig, Maika; Hach, Faraz; Yorukoglu, Deniz; Dao, Phuong; Bakhshi, Marzieh; Sahinalp, S. Cenk; Eichler, Evan E.

2011-01-01

Human genomes are now being rapidly sequenced, but not all forms of genetic variation are routinely characterized. In this study, we focus on Alu retrotransposition events and seek to characterize differences in the pattern of mobile insertion between individuals based on the analysis of eight human genomes sequenced using next-generation sequencing. Applying a rapid read-pair analysis algorithm, we discover 4342 Alu insertions not found in the human reference genome and show that 98% of a selected subset (63/64) experimentally validate. Of these new insertions, 89% correspond to AluY elements, suggesting that they arose by retrotransposition. Eighty percent of the Alu insertions have not been previously reported and more novel events were detected in Africans when compared with non-African samples (76% vs. 69%). Using these data, we develop an experimental and computational screen to identify ancestry informative Alu retrotransposition events among different human populations. PMID:21131385

Statistical Profiling of One Promiscuous Protein Binding Site: Illustrated by Urokinase Catalytic Domain.

PubMed

Cerisier, Natacha; Regad, Leslie; Triki, Dhoha; Petitjean, Michel; Flatters, Delphine; Camproux, Anne-Claude

2017-10-01

While recent literature focuses on drug promiscuity, the characterization of promiscuous binding sites (ability to bind several ligands) remains to be explored. Here, we present a proteochemometric modeling approach to analyze diverse ligands and corresponding multiple binding sub-pockets associated with one promiscuous binding site to characterize protein-ligand recognition. We analyze both geometrical and physicochemical profile correspondences. This approach was applied to examine the well-studied druggable urokinase catalytic domain inhibitor binding site, which results in a large number of complex structures bound to various ligands. This approach emphasizes the importance of jointly characterizing pocket and ligand spaces to explore the impact of ligand diversity on sub-pocket properties and to establish their main profile correspondences. This work supports an interest in mining available 3D holo structures associated with a promiscuous binding site to explore its main protein-ligand recognition tendency. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Characterization of Oaxaca raw milk cheese microbiota with particular interest in Lactobacillus strains.

PubMed

Caro, Irma; Mateo, Javier; Sandoval, María H; Soto, Sergio; García-Armesto, María R; Castro, José M

2013-06-01

The aim of this work was to identify and characterize lactobacilli strains from Mexican Oaxaca cheese. Twenty-seven lactobacilli isolated from Oaxaca cheese were identified at species level by 16S rRNA sequencing. Selected isolates were further characterized by ribotyping. Isolates were screened, among others, by acidifying capacity, antibiotic resistance, and activity against pathogens. Lactobacillus plantarum was predominant in Oaxaca cheese. The intraspecies variability of Lb. plantarum isolates was great. Multiple antibiotic resistances were observed. Eight isolates showed antimicrobial activity against the pathogenic species tested. Four Lb. plantarum strains showing low antibiotic resistance index, antimicrobial activity against enterotoxigenic Staphylococcus aureus and Listeria innocua stains, amine-negative decarboxylase activity, and resistance to NaCl and bile salt solutions, could be preselected to complete studies focused on designing a culture for use in pasteurized-milk Oaxaca cheese manufacturing. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Structural Characterization of the Low-Molecular-Weight Heparin Dalteparin by Combining Different Analytical Strategies.

PubMed

Bisio, Antonella; Urso, Elena; Guerrini, Marco; de Wit, Pauline; Torri, Giangiacomo; Naggi, Annamaria

2017-06-24

A number of low molecular weight heparin (LMWH) products are available for clinical use and although all share a similar mechanism of action, they are classified as distinct drugs because of the different depolymerisation processes of the native heparin resulting in substantial pharmacokinetic and pharmacodynamics differences. While enoxaparin has been extensively investigated, little information is available regarding the LMWH dalteparin. The present study is focused on the detailed structural characterization of Fragmin ® by LC-MS and NMR applied both to the whole drug and to its enzymatic products. For a more in-depth approach, size homogeneous octasaccharide and decasaccharide components together with their fractions endowed with high or no affinity toward antithrombin were also isolated and their structural profiles characterized. The combination of different analytical strategies here described represents a useful tool for the assessment of batch-to-batch structural variability and for comparative evaluation of structural features of biosimilar products.

Bacteriocins from Lactobacillus plantarum - production, genetic organization and mode of action: produção, organização genética e modo de ação.

PubMed

Todorov, Svetoslav D

2009-04-01

Bacteriocins are biologically active proteins or protein complexes that display a bactericidal mode of action towards usually closely related species. Numerous strains of bacteriocin producing Lactobacillus plantarum have been isolated in the last two decades from different ecological niches including meat, fish, fruits, vegetables, and milk and cereal products. Several of these plantaricins have been characterized and the aminoacid sequence determined. Different aspects of the mode of action, fermentation optimization and genetic organization of the bacteriocin operon have been studied. However, numerous of bacteriocins produced by different Lactobacillus plantarum strains have not been fully characterized. In this article, a brief overview of the classification, genetics, characterization, including mode of action and production optimization for bacteriocins from Lactic Acid Bacteria in general, and where appropriate, with focus on bacteriocins produced by Lactobacillus plantarum, is presented.

How are learning strategies reflected in the eyes? Combining results from self-reports and eye-tracking.

PubMed

Catrysse, Leen; Gijbels, David; Donche, Vincent; De Maeyer, Sven; Lesterhuis, Marije; Van den Bossche, Piet

2018-03-01

Up until now, empirical studies in the Student Approaches to Learning field have mainly been focused on the use of self-report instruments, such as interviews and questionnaires, to uncover differences in students' general preferences towards learning strategies, but have focused less on the use of task-specific and online measures. This study aimed at extending current research on students' learning strategies by combining general and task-specific measurements of students' learning strategies using both offline and online measures. We want to clarify how students process learning contents and to what extent this is related to their self-report of learning strategies. Twenty students with different generic learning profiles (according to self-report questionnaires) read an expository text, while their eye movements were registered to answer questions on the content afterwards. Eye-tracking data were analysed with generalized linear mixed-effects models. The results indicate that students with an all-high profile, combining both deep and surface learning strategies, spend more time on rereading the text than students with an all-low profile, scoring low on both learning strategies. This study showed that we can use eye-tracking to distinguish very strategic students, characterized using cognitive processing and regulation strategies, from low strategic students, characterized by a lack of cognitive and regulation strategies. These students processed the expository text according to how they self-reported. © 2017 The British Psychological Society.

Principal Professional Learning Community Behavior in Low Wealth High Schools with Higher and Lower Student Achievement as Measured by Mastery Scores on the New York State Eleventh Grade ELA Regents Exam

ERIC Educational Resources Information Center

Adams, Adrian

2016-01-01

This study was designed to analyze non-principal staff supervisors' perceptions of PLC efforts, encouragements, and activities in the six dimensions of a professional learning community (PLC) characterized as shared and supportive leadership, shared values and vision, collaborative culture, a focus on learning, supportive relationships, and…

A Comparative Analysis Regarding Factors Related to 13- to 18-Year-Old African American Male Adolescents in Special Education and the Justice System

ERIC Educational Resources Information Center

Phipps, Jonathan Lanier

2013-01-01

This study was focused on the identification of selected risk factors seemingly present among African American male adolescents 13 to 18 years old who were participants in special education programs at their schools. Many of these male adolescents were also found to participate in the juvenile justice system under what was characterized as…

Engineering metallic nanostructures for plasmonics and nanophotonics

PubMed Central

Lindquist, Nathan C; Nagpal, Prashant; McPeak, Kevin M; Norris, David J; Oh, Sang-Hyun

2012-01-01

Metallic nanostructures now play an important role in many applications. In particular, for the emerging fields of plasmonics and nanophotonics, the ability to engineer metals on nanometric scales allows the development of new devices and the study of exciting physics. This review focuses on top-down nanofabrication techniques for engineering metallic nanostructures, along with computational and experimental characterization techniques. A variety of current and emerging applications are also covered. PMID:22790420

Saturation-Transfer Difference (STD) NMR: A Simple and Fast Method for Ligand Screening and Characterization of Protein Binding

ERIC Educational Resources Information Center

Viegas, Aldino; Manso, Joao; Nobrega, Franklin L.; Cabrita, Eurico J.

2011-01-01

Saturation transfer difference (STD) NMR has emerged as one of the most popular ligand-based NMR techniques for the study of protein-ligand interactions. The success of this technique is a consequence of its robustness and the fact that it is focused on the signals of the ligand, without any need of processing NMR information about the receptor…

Optical Spectroscopy of Hybrid Semiconductor Quantum Dots and Metal Nanoparticles

DTIC Science & Technology

2014-11-07

Theoretical studies of spin- photon entangled complementarity”. Mr. Anderson Hayes in physics finished B.S. degree in May 2013 with a capstone thesis entitled...working on “Semiconductor quantum dots and photon entanglement ”. Mr. Quinn Allen Hailes, undergraduate student in physics completed B.S. degree in...great interests for the Department of Defense’s (DoD) photonic applications. Our research focused on developing and characterizing advanced optical

Characterizing the Hercules Thick Disk Cloud

DTIC Science & Technology

2009-01-01

merger. Key Words: Astronomy , Hercules Thick Disk Cloud, Galaxy, Star Count, Color, Photometric Parallax 2 Contents Chapter 1... Astronomy : Structure and Kinematics, 2nd ed., New York: W. H. Freeman and Company, 1981, pp 4. 5 Henbest, Guide, pp 10. 6 Mihalas, Galactic, pp 209...studies of astronomy later in his life, he focused on binary star systems and concluded that not all stars have the same absolute magnitude, thus

"Look It, This Is How You Know:" Family Forest Walks as a Context for Knowledge-Building about the Natural World

ERIC Educational Resources Information Center

Marin, Ananda; Bang, Megan

2018-01-01

This case study focuses on a Native American family's experience on a walk in an urban forest preserve. Drawing on interaction analysis traditions, we analyze video data and transcript data to characterize how learning unfolds in place, in this case an urban forest. We build on this analysis, as well as the work of Indigenous scholars, to…

Engineering metallic nanostructures for plasmonics and nanophotonics

NASA Astrophysics Data System (ADS)

Lindquist, Nathan C.; Nagpal, Prashant; McPeak, Kevin M.; Norris, David J.; Oh, Sang-Hyun

2012-03-01

Metallic nanostructures now play an important role in many applications. In particular, for the emerging fields of plasmonics and nanophotonics, the ability to engineer metals on nanometric scales allows the development of new devices and the study of exciting physics. This review focuses on top-down nanofabrication techniques for engineering metallic nanostructures, along with computational and experimental characterization techniques. A variety of current and emerging applications are also covered.

Seafood workers and respiratory disease: an update.

PubMed

Jeebhay, Mohamed F; Cartier, André

2010-04-01

This review focuses on seafood workers engaged in harvesting, processing and food preparation. These groups are increasingly at risk of developing occupational allergy and respiratory disease as a result of seafood handling and processing activities. This review provides an update of a previous review conducted a decade ago. Exposure characterization studies have demonstrated that aerosolization of seafood (muscle, visceral organs, skin/mucin) during canning and fishmeal operations result in highly variable levels of airborne particulate (0.001-11.293 mg/m3) and allergens (0.001-75.748 ug/m3). Occupational asthma is more commonly associated with shellfish (4-36%) than with bony fish (2-8%). Other seafood-associated biological (Anisakis) and chemical agents (protease enzymes, toxins and preservatives) have also been implicated. Atopy, smoking and level of exposure to allergens are significant risk factors for sensitization and the development of occupational asthma. Molecular studies of the allergens suggest that aside from tropomyosin and parvalbumin, other as yet uncharacterized allergens are important. Future research needs to focus on detailed characterization of allergens in order to standardize exposure assessment techniques, which are key to assessing the impact of interventions. The clinical relevance of agents such as serine proteases and endotoxins in causing asthma through nonallergic mechanisms needs further epidemiological investigation.

Perspectives and challenges of photon-upconversion nanoparticles - Part I: routes to brighter particles and quantitative spectroscopic studies.

PubMed

Resch-Genger, Ute; Gorris, Hans H

2017-10-01

Lanthanide-doped photon-upconversion nanoparticles (UCNPs) have been the focus of many research activities in materials and life sciences in the last 15 years because of their potential to convert light between different spectral regions and their unique photophysical properties. To fully exploit the application potential of these fascinating nanomaterials, a number of challenges have to be overcome, such as the low brightness, particularly of small UCNPs, and the reliable quantification of the excitation-power-density-dependent upconversion luminescence. In this series of critical reviews, recent developments in the design, synthesis, optical-spectroscopic characterization, and application of UCNPs are presented with special focus on bioanalysis and the life sciences. Here we guide the reader from the synthesis of UCNPs to different concepts to enhance their luminescence, including the required optical-spectroscopic assessment to quantify material performance; surface modification strategies and bioanalytical applications as well as selected examples of the use of UCNPs as reporters in different assay formats are addressed in part II. Future trends and challenges in the field of upconversion are discussed with special emphasis on UCNP synthesis and material characterization, particularly quantitative luminescence studies. Graphical Abstract Both synthesis and spectroscopy as well bioanalytical applications of UCNPs are driven and supported by COST Action CM1403 "The European Upconversion Network".

Attachment-based family therapy and emotion-focused therapy for unresolved anger: The role of productive emotional processing.

PubMed

Diamond, Gary M; Shahar, Ben; Sabo, Daphna; Tsvieli, Noa

2016-03-01

A growing body of research suggests that emotional processing is a central and common change mechanism across various types of therapies (Diener & Hilsenroth, 2009; Foa, Huppert, & Cahill, 2006; Greenberg, 2011). This study examined whether 10 weeks of attachment-based family therapy (ABFT), characterized by the use of in-session young adult-parent dialogues, were more effective than 10 weeks of individual emotion-focused therapy (EFT), characterized by the use of imaginal dialogues, in terms of facilitating productive emotional processing among a sample of 32 young adults presenting with unresolved anger toward a parent. This study also examined whether greater amounts of productive emotional processing predicted more favorable treatment outcomes. In contrast to our expectations, we found significantly more productive emotional processing in individual EFT than in conjoint ABFT. Results also showed that while both treatments led to significant and equivalent decreases in unresolved anger, state anger, attachment anxiety, and psychological symptoms, only ABFT was associated with decreases in attachment avoidance. Although amount of emotional processing did not explain the unique decrease in attachment avoidance in ABFT, greater amounts of productive emotional processing predicted greater decreases in psychological symptoms (but not other outcome measures) across both treatments. (c) 2016 APA, all rights reserved).

Thermal characterizations of a large-format lithium ion cell focused on high current discharges

NASA Astrophysics Data System (ADS)

Veth, C.; Dragicevic, D.; Merten, C.

2014-12-01

The thermal behavior of a large-format lithium ion cell has been investigated during measurements on cell and battery level. High current discharges up to 300 A are the main topic of this study. This paper demonstrates that the temperature response to high current loads provides the possibility to investigate internal cell parameters and their inhomogeneity. In order to identify thermal response caused by internal cell processes, the heat input due to contact resistances has been minimized. The differences between the thermal footprint of a cell during cell and battery measurements are being addressed. The study presented here focuses on the investigation of thermal hot and cold spots as well as temperature gradients in a 50 Ah pouch cell. Furthermore, it is demonstrated that the difference between charge and discharge can have significant influence on the thermal behavior of lithium ion cells. Moreover, the miscellaneous thermal characteristics of differently aged lithium ion cells highlight the possibility of an ex-situ non-destructive post-mortem-analysis, providing the possibility of a qualitative and quantitative characterization of inhomogeneous cell-aging. These investigations also generate excellent data for the validation and parameterization of electro-thermal cell models, predicting the distribution of temperature, current, potential, SOC and SOH inside large-format cells.

Acoustic characterization of Thiel liver for magnetic resonance-guided focused ultrasound treatment.

PubMed

Karakitsios, Ioannis; Joy, Joyce; Mihcin, Senay; Melzer, Andreas

2017-04-01

The purpose of this work was to measure the essential acoustic parameters, i.e., acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS). Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i.e., acoustic impedance, reflection coefficient and attenuation coefficient of Thiel embalmed human and animal liver were measured. The Thiel embalmed livers had higher impedance, similar reflection and lower attenuation compared to the fresh tissue. Embalming liver with Thiel fluid affects its acoustic properties. During MRgFUS sonication of a Thiel organ, more focused ultrasound (FUS) will be backscattered by the organ, and higher acoustic powers are required to reach coagulation levels (temperatures >56 °C).

"Data characterizing microfabricated human blood vessels created via hydrodynamic focusing".

PubMed

DiVito, Kyle A; Daniele, Michael A; Roberts, Steven A; Ligler, Frances S; Adams, André A

2017-10-01

This data article provides further detailed information related to our research article titled "Microfabricated Blood Vessels Undergo Neovascularization" (DiVito et al., 2017) [1], in which we report fabrication of human blood vessels using hydrodynamic focusing (HDF). Hydrodynamic focusing with advection inducing chevrons were used in concert to encase one fluid stream within another, shaping the inner core fluid into 'bullseye-like" cross-sections that were preserved through click photochemistry producing streams of cellularized hollow 3-dimensional assemblies, such as human blood vessels (Daniele et al., 2015a, 2015b, 2014, 2016; Roberts et al., 2016) [2], [3], [4], [5], [6]. Applications for fabricated blood vessels span general tissue engineering to organ-on-chip technologies, with specific utility in in vitro drug delivery and pharmacodynamics studies. Here, we report data regarding the construction of blood vessels including cellular composition and cell positioning within the engineered vascular construct as well as functional aspects of the tissues.

Microstructure characterization of multi-phase composites and utilization of phase change materials and recycled rubbers in cementitious materials

NASA Astrophysics Data System (ADS)

Meshgin, Pania

2011-12-01

This research focuses on two important subjects: (1) Characterization of heterogeneous microstructure of multi-phase composites and the effect of microstructural features on effective properties of the material. (2) Utilizations of phase change materials and recycled rubber particles from waste tires to improve thermal properties of insulation materials used in building envelopes. Spatial pattern of multi-phase and multidimensional internal structures of most composite materials are highly random. Quantitative description of the spatial distribution should be developed based on proper statistical models, which characterize the morphological features. For a composite material with multi-phases, the volume fraction of the phases as well as the morphological parameters of the phases have very strong influences on the effective property of the composite. These morphological parameters depend on the microstructure of each phase. This study intends to include the effect of higher order morphological details of the microstructure in the composite models. The higher order statistics, called two-point correlation functions characterize various behaviors of the composite at any two points in a stochastic field. Specifically, correlation functions of mosaic patterns are used in the study for characterizing transport properties of composite materials. One of the most effective methods to improve energy efficiency of buildings is to enhance thermal properties of insulation materials. The idea of using phase change materials and recycled rubber particles such as scrap tires in insulation materials for building envelopes has been studied.

Fast photorefractive self focusing in InP:Fe semiconductor at near infrared wavelengths

NASA Astrophysics Data System (ADS)

Wolfersberger, Delphine; Dan, Cristian; Khelfaoui, Naïma; Fressengeas, Nicolas; Hervé, Leblond

2008-04-01

Self-trapping of optical beams in photorefractive (PR) materials at telecommunications wavelengths has been studied at steady state in insulators such as SBN [1] and in semiconductor InP:Fe [2], CdTe [3]. PR self-focusing and soliton interactions in semiconductors find interesting applications in optical communications such as optical routing and interconnections because of several advantages over insulators: their sensitivity to near-infrared wavelengths and shorter response time. Photorefractive self focusing in InP:Fe is characterized as a function of beam intensity and temperature. Transient self focusing is found to occur on two time scales for input intensities of tens of W/cm2 (one on the order of tens of μs, one on the order of milliseconds). A theory developed describes the photorefractive self focusing in InP:Fe and confirmed by steady state and transient regime measurements. PR associated phenomena (bending and self focusing) are taking place in InP:Fe as fast as a μs for intensities on the order of 10W/cm2 at 1.06 μm. Currently we are conducting more experiments in order to estimate the self focusing response time at 1.55μm, to clarify the temporal dynamic of the self focusing and to build up a demonstrator of fast optical routing by photorefractive spatial solitons interactions.

Maternal health development programs: comparing priorities of bilateral and private donors.

PubMed

Deleye, Cécile; Lang, Achim

2014-11-19

The face of international aid for health and development is changing. Private donors such as foundations and corporations are playing an increasingly important role, working in international development as direct operators or in partnerships with governments. This study compares maternal health programs of new development actors to traditional governmental donors. It aims to investigate what maternal health programs large governmental donors, foundations and corporate donors are conducting, and how and why they differ. A total of 263 projects were identified and analyzed. We focus on nine categories of maternal health programs: family planning services, focus on specific diseases, focus on capacity building, use of information and communication technology (ICT), support of research initiatives, cooperation with local non-state or state partners and cooperation with non-local non-state or state partners. Data analysis was carried out using Generalized Linear Mixed-Effects Models (GLMER). Maternal health policies of public and private donors differ with regard to strategic approaches, as can be seen in their diverging positions regarding disease focus, family planning services, capacity building, and partner choice. Bilateral donors can be characterized as focusing on family planning services, specific diseases and capacity-building while disregarding research and ICT. Bilateral donors cooperate with local public authorities and with governments and NGOs from other developed countries. In contrast, corporations focus their donor activities on specific diseases, capacity-building and ICT while disregarding family planning services and research. Corporations cooperate with local and in particular with non-local non-state actors. Foundations can be characterized as focusing on family planning services and research, while disregarding specific diseases, capacity-building and ICT. Foundations cooperate less than other donors; but when they do, they cooperate in particular with non-state actors, local as well as non-local. These findings should help developing coordination mechanisms that embrace the differences and similarities of the different types of donors. As donor groups specialize in different contexts, NGOs and governments working on development and health aid may target donors groups that have specialized in certain issues.

Single-Molecule Interfacial Electron Transfer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, H. Peter

This project is focused on the use of single-molecule high spatial and temporal resolved techniques to study molecular dynamics in condensed phase and at interfaces, especially, the complex reaction dynamics associated with electron and energy transfer rate processes. The complexity and inhomogeneity of the interfacial ET dynamics often present a major challenge for a molecular level comprehension of the intrinsically complex systems, which calls for both higher spatial and temporal resolutions at ultimate single-molecule and single-particle sensitivities. Combined single-molecule spectroscopy and electrochemical atomic force microscopy approaches are unique for heterogeneous and complex interfacial electron transfer systems because the static andmore » dynamic inhomogeneities can be identified and characterized by studying one molecule at a specific nanoscale surface site at a time. The goal of our project is to integrate and apply these spectroscopic imaging and topographic scanning techniques to measure the energy flow and electron flow between molecules and substrate surfaces as a function of surface site geometry and molecular structure. We have been primarily focusing on studying interfacial electron transfer under ambient condition and electrolyte solution involving both single crystal and colloidal TiO 2 and related substrates. The resulting molecular level understanding of the fundamental interfacial electron transfer processes will be important for developing efficient light harvesting systems and broadly applicable to problems in fundamental chemistry and physics. We have made significant advancement on deciphering the underlying mechanism of the complex and inhomogeneous interfacial electron transfer dynamics in dyesensitized TiO 2 nanoparticle systems that strongly involves with and regulated by molecule-surface interactions. We have studied interfacial electron transfer on TiO 2 nanoparticle surfaces by using ultrafast single-molecule spectroscopy and electrochemical AFM metal tip scanning microscopy, focusing on understanding the interfacial electron transfer dynamics at specific nanoscale electron transfer sites with high-spatially and temporally resolved topographic-and-spectroscopic characterization at individual molecule basis, characterizing single-molecule rate processes, reaction driving force, and molecule-substrate electronic coupling. One of the most significant characteristics of our new approach is that we are able to interrogate the complex interfacial electron transfer dynamics by actively pin-point energetic manipulation of the surface interaction and electronic couplings, beyond the conventional excitation and observation.« less

Counterinsurgency and Its Implications for the Norwegian Special Operations Forces

DTIC Science & Technology

2008-06-01

purely domestic focus, or in the absence of any direct threat, a more international focus. The latter view has prevailed. Since 2001, the NAF have...characterized more by unorthodox threats like for example insurgencies, international terrorism ,etc., and less by “conventional” wars between...sought their independence; many by insurgency or a war of liberation . As the Cold War was at its height, most countries’ main focus was on large

Design and Characterization of Dual-Curvature 1.5-Dimensional High-Intensity Focused Ultrasound Phased-Array Transducer

PubMed Central

Chen, Gin-Shin; Lin, Che-Yu; Jeong, Jong Seob; Cannata, Jonathan M.; Lin, Win-Li; Chang, Hsu; Shung, K. Kirk

2013-01-01

A dual-curvature focused ultrasound phased-array transducer with a symmetric control has been developed for noninvasive ablative treatment of tumors. The 1.5-D array was constructed in-house and the electro-acoustic conversion efficiency was measured to be approximately 65%. In vitro experiments demonstrated that the array uses 256 independent elements to achieve 2-D wide-range high-intensity electronic focusing. PMID:22293745

Applications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterials

PubMed Central

Wu, Peiwen; Yu, Yang; McGhee, Claire E.; Tan, Li Huey

2014-01-01

In this review, we summarize recent progresses in the application of synchrotron-based spectroscopic techniques for nucleic acid research that takes advantage of high-flux and high-brilliance electromagnetic radiation from synchrotron sources. The first section of the review focuses on the characterization of the structure and folding processes of nucleic acids using different types of synchrotron-based spectroscopies, such as X-ray absorption spectroscopy, X-ray emission spectroscopy, X-ray photoelectron spectroscopy, synchrotron radiation circular dichroism, X-ray footprinting and small-angle X-ray scattering. In the second section, the characterization of nucleic acid-based nanostructures, nucleic acid-functionalized nanomaterials and nucleic acid-lipid interactions using these spectroscopic techniques is summarized. Insights gained from these studies are described and future directions of this field are also discussed. PMID:25205057

Characterization of probiotic bacteria involved in fermented milk processing enriched with folic acid.

PubMed

Wu, Zhen; Wu, Jing; Cao, Pei; Jin, Yifeng; Pan, Daodong; Zeng, Xiaoqun; Guo, Yuxing

2017-06-01

Yogurt products fermented with probiotic bacteria are a consumer trend and a challenge for functional food development. So far, limited research has focused on the behavior of the various probiotic strains used in milk fermentation. In the present study, we characterized folic acid production and the sensory and textural characteristics of yogurt products fermented with probiotic bacteria. Yogurt fermented with Lactobacillus plantarum had improved nutrient content and sensory and textural characteristics, but the presence of L. plantarum significantly impaired the growth and survival of Lactobacillus delbrueckii ssp. bulgaricus during refrigerated storage. Overall, L. plantarum was a good candidate for probiotic yogurt fermentation; further studies are needed to understand the major metabolite path of lactic acid bacteria in complex fermentation. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Applications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterials

DOE PAGES

Wu, Peiwen; Yu, Yang; McGhee, Claire E.; ...

2014-09-10

In this paper, we summarize recent progress in the application of synchrotron-based spectroscopic techniques for nucleic acid research that takes advantage of high-flux and high-brilliance electromagnetic radiation from synchrotron sources. The first section of the review focuses on the characterization of the structure and folding processes of nucleic acids using different types of synchrotron-based spectroscopies, such as X-ray absorption spectroscopy, X-ray emission spectroscopy, X-ray photoelectron spectroscopy, synchrotron radiation circular dichroism, X-ray footprinting and small-angle X-ray scattering. In the second section, the characterization of nucleic acid-based nanostructures, nucleic acid-functionalized nanomaterials and nucleic acid-lipid interactions using these spectroscopic techniques is summarized. Insightsmore » gained from these studies are described and future directions of this field are also discussed.« less

Three-dimensional microstructural characterization of bulk plutonium and uranium metals using focused ion beam technique

NASA Astrophysics Data System (ADS)

Chung, Brandon W.; Erler, Robert G.; Teslich, Nick E.

2016-05-01

Nuclear forensics requires accurate quantification of discriminating microstructural characteristics of the bulk nuclear material to identify its process history and provenance. Conventional metallographic preparation techniques for bulk plutonium (Pu) and uranium (U) metals are limited to providing information in two-dimension (2D) and do not allow for obtaining depth profile of the material. In this contribution, use of dual-beam focused ion-beam/scanning electron microscopy (FIB-SEM) to investigate the internal microstructure of bulk Pu and U metals is demonstrated. Our results demonstrate that the dual-beam methodology optimally elucidate microstructural features without preparation artifacts, and the three-dimensional (3D) characterization of inner microstructures can reveal salient microstructural features that cannot be observed from conventional metallographic techniques. Examples are shown to demonstrate the benefit of FIB-SEM in improving microstructural characterization of microscopic inclusions, particularly with respect to nuclear forensics.

Three-dimensional microstructural characterization of bulk plutonium and uranium metals using focused ion beam technique

DOE PAGES

Chung, Brandon W.; Erler, Robert G.; Teslich, Nick E.

2016-03-03

Nuclear forensics requires accurate quantification of discriminating microstructural characteristics of the bulk nuclear material to identify its process history and provenance. Conventional metallographic preparation techniques for bulk plutonium (Pu) and uranium (U) metals are limited to providing information in two-dimension (2D) and do not allow for obtaining depth profile of the material. In this contribution, use of dual-beam focused ion-beam/scanning electron microscopy (FIB-SEM) to investigate the internal microstructure of bulk Pu and U metals is demonstrated. Our results demonstrate that the dual-beam methodology optimally elucidate microstructural features without preparation artifacts, and the three-dimensional (3D) characterization of inner microstructures can revealmore » salient microstructural features that cannot be observed from conventional metallographic techniques. As a result, examples are shown to demonstrate the benefit of FIB-SEM in improving microstructural characterization of microscopic inclusions, particularly with respect to nuclear forensics.« less

Scanning Angle Raman spectroscopy in polymer thin film characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Vy H.T.

The focus of this thesis is the application of Raman spectroscopy for the characterization of thin polymer films. Chapter 1 provides background information and motivation, including the fundamentals of Raman spectroscopy for chemical analysis, scanning angle Raman scattering and scanning angle Raman scattering for applications in thin polymer film characterization. Chapter 2 represents a published manuscript that focuses on the application of scanning angle Raman spectroscopy for the analysis of submicron thin films with a description of methodology for measuring the film thickness and location of an interface between two polymer layers. Chapter 3 provides an outlook and future directionsmore » for the work outlined in this thesis. Appendix A, contains a published manuscript that outlines the use of Raman spectroscopy to aid in the synthesis of heterogeneous catalytic systems. Appendix B and C contain published manuscripts that set a foundation for the work presented in Chapter 2.« less

Characterization of cookstove emissions from various stoves, fuels, and cycles; intervention pathways and implications for climate

NASA Astrophysics Data System (ADS)

DeCarlo, P. F.; Jetter, J.; Khan, B.; Zhao, Y.; Yelverton, T.; Hays, M. D.

2011-12-01

Nearly half of the world's population relies on inefficient open fire or rudimentary cookstoves to prepare their food. Combustion of biomass or other fuels results in not only high indoor air pollution, but is also a large source of climate forcing species such as black and organic carbon species to the earth's atmosphere. Large-scale intervention programs are now underway to replace inefficient cooking methods with newer technologies. These intervention programs have as a goal the improvement of indoor air pollution and reduction of negative climate impacts. To characterize the current available alternatives, a major cookstove testing program was conducted at the US EPA. This presentation will focus on the characterization of the emission measurements for a variety of different cookstoves, fuels and cooking cycles. The work will focus on the aerosol optical properties measured with a PASS-3, and the climate impacts of various intervention pathways will be discussed.

Characterization of a subwavelength-scale 3D void structure using the FDTD-based confocal laser scanning microscopic image mapping technique.

PubMed

Choi, Kyongsik; Chon, James W; Gu, Min; Lee, Byoungho

2007-08-20

In this paper, a simple confocal laser scanning microscopic (CLSM) image mapping technique based on the finite-difference time domain (FDTD) calculation has been proposed and evaluated for characterization of a subwavelength-scale three-dimensional (3D) void structure fabricated inside polymer matrix. The FDTD simulation method adopts a focused Gaussian beam incident wave, Berenger's perfectly matched layer absorbing boundary condition, and the angular spectrum analysis method. Through the well matched simulation and experimental results of the xz-scanned 3D void structure, we first characterize the exact position and the topological shape factor of the subwavelength-scale void structure, which was fabricated by a tightly focused ultrashort pulse laser. The proposed CLSM image mapping technique based on the FDTD can be widely applied from the 3D near-field microscopic imaging, optical trapping, and evanescent wave phenomenon to the state-of-the-art bio- and nanophotonics.

Optimization and resilience in natural resources management

USGS Publications Warehouse

Williams, Byron K.; Johnson, Fred A.

2015-01-01

We consider the putative tradeoff between optimization and resilience in the management of natural resources, using a framework that incorporates different sources of uncertainty that are common in natural resources management. We address one-time decisions, and then expand the decision context to the more complex problem of iterative decision making. For both cases we focus on two key sources of uncertainty: partial observability of system state and uncertainty as to system dynamics. Optimal management strategies will vary considerably depending on the timeframe being considered and the amount and quality of information that is available to characterize system features and project the consequences of potential decisions. But in all cases an optimal decision making framework, if properly identified and focused, can be useful in recognizing sound decisions. We argue that under the conditions of deep uncertainty that characterize many resource systems, an optimal decision process that focuses on robustness does not automatically induce a loss of resilience.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cessi, Paola; Wolfe, Christopher L.

This project concerned the Atlantic Meridional Overturning Circulation (AMOC), its stability, variability and sensitivity to atmospheric forcing, both mechanical (wind-stress) and thermodynamical (heat and freshwater surface fluxes). The focus of the study is the interhemispheric cell in the largely adiabatic regime, where the flow is characterized by a descending branch in the high latitudes of the North Atlantic and the upwelling branch in the Antarctic Circumpolar Current (ACC) region of the Southern Ocean. These two end points are connected by shared isopycnals along which the flow takes place. The approach is to systematically study the amplitude and frequency of themore » AMOC’s response to localized buoyancy with an ocean-only model in both coarse and high-resolution configurations, analyzed with innovative diagnostics, focused on the “residual overturning circulation” (ROC), which is the proper measure of the transport of heat and other tracers.« less

Noise-induced errors in geophysical parameter estimation from retarding potential analyzers in low Earth orbit

NASA Astrophysics Data System (ADS)

Debchoudhury, Shantanab; Earle, Gregory

2017-04-01

Retarding Potential Analyzers (RPA) have a rich flight heritage. Standard curve-fitting analysis techniques exist that can infer state variables in the ionospheric plasma environment from RPA data, but the estimation process is prone to errors arising from a number of sources. Previous work has focused on the effects of grid geometry on uncertainties in estimation; however, no prior study has quantified the estimation errors due to additive noise. In this study, we characterize the errors in estimation of thermal plasma parameters by adding noise to the simulated data derived from the existing ionospheric models. We concentrate on low-altitude, mid-inclination orbits since a number of nano-satellite missions are focused on this region of the ionosphere. The errors are quantified and cross-correlated for varying geomagnetic conditions.

Evaluation of performance of the MACAO systems at the VLTI

NASA Astrophysics Data System (ADS)

Rengaswamy, Sridharan; Haguenauer, Pierre; Brillant, Stephane; Cortes, Angela; Girard, Julien H.; Guisard, Stephane; Paufique, Jérôme; Pino, Andres

2010-07-01

Multiple Application Curvature Adaptive Optics (MACAO) systems are used at the coudé focus of the unit telescopes (UTs) at the La-Silla Paranal Observatory, Paranal, to correct for the wave-front aberrations induced by the atmosphere. These systems are in operation since 2005 and are designed to provide beams with 10 mas residual rms tip-tilt error to the VLTI laboratory. We have initiated several technical studies such as measuring the Strehl ratio of the images recorded at the guiding camera of the VLTI, establishing the optimum setup of the MACAO to get collimated and focused beam down to the VLTI laboratory and to the instruments, and ascertaining the data generated by the real time computer, all aimed at characterizing and improving the overall performance of these systems. In this paper we report the current status of these studies.

Assessing Human Health Risk to Endocrine Disrupting Chemicals: a Focus on Prenatal Exposures and Oxidative Stress

PubMed Central

Neier, Kari; Marchlewicz, Elizabeth H.; Dolinoy, Dana C.; Padmanabhan, Vasantha

2016-01-01

Understanding the health risk posed by endocrine disrupting chemicals (EDCs) is a challenge that is receiving intense attention. The following study criteria should be considered to facilitate risk assessment for exposure to EDCs: 1) characterization of target health outcomes and their mediators, 2) study of exposures in the context of critical periods of development, 3) accurate estimates of human exposures and use of human-relevant exposures in animal studies, and 4) cross-species comparisons. In this commentary, we discuss the importance and relevance of each of these criteria in studying the effects of prenatal exposure to EDCs. Our discussion focuses on oxidative stress as a mediator of EDC-related health effects due to its association with both EDC exposure and health outcomes. Our recent study (Veiga-Lopez et al. 2015)1 addressed each of the four outlined criteria and demonstrated that prenatal bisphenol-A exposure is associated with oxidative stress, a risk factor for developing diabetes and cardiovascular diseases in adulthood. PMID:27231701

How to Study Thermal Applications of Open-Cell Metal Foam: Experiments and Computational Fluid Dynamics

PubMed Central

De Schampheleire, Sven; De Jaeger, Peter; De Kerpel, Kathleen; Ameel, Bernd; Huisseune, Henk; De Paepe, Michel

2016-01-01

This paper reviews the available methods to study thermal applications with open-cell metal foam. Both experimental and numerical work are discussed. For experimental research, the focus of this review is on the repeatability of the results. This is a major concern, as most studies only report the dependence of thermal properties on porosity and a number of pores per linear inch (PPI-value). A different approach, which is studied in this paper, is to characterize the foam using micro tomography scans with small voxel sizes. The results of these scans are compared to correlations from the open literature. Large differences are observed. For the numerical work, the focus is on studies using computational fluid dynamics. A novel way of determining the closure terms is proposed in this work. This is done through a numerical foam model based on micro tomography scan data. With this foam model, the closure terms are determined numerically. PMID:28787894

Transiting Exoplanet Studies and Community Targets for JWST's Early Release Science Program

NASA Technical Reports Server (NTRS)

Stevenson, Kevin B.; Lewis, Nikole K.; Bean, Jacob L.; Beichman, Charles A.; Fraine, Jonathan; Kilpatrick, Brian M.; Krick, J. E.; Lothringer, Joshua D.; Mandell, Avi M.; Valenti, Jeff A.;

Transiting Exoplanet Studies and Community Targets for JWST's Early Release Science Program

NASA Technical Reports Server (NTRS)

Stevenson, Kevin B.; Lewis, Nikole K.; Bean, Jacob L.; Beichman, Charles; Fraine, Jonathan; Kilpatrick, Brian M.; Krick, J. E.; Lothringer, Joshua D.; Mandell, Avi M.; Valenti, Jeff A.;

Application of Satellite and Ozonesonde Data to the Study of Nighttime Tropospheric Ozone Impacts and Relationship to Air Quality

NASA Astrophysics Data System (ADS)

Osterman, G. B.; Eldering, A.; Neu, J. L.; Tang, Y.; McQueen, J.; Pinder, R. W.

2011-12-01

To help protect human health and ecosystems, regional-scale atmospheric chemistry models are used to forecast high ozone events and to design emission control strategies to decrease the frequency and severity of ozone events. Despite the impact that nighttime aloft ozone can have on surface ozone, regional-scale atmospheric chemistry models often do not simulate the nighttime ozone concentrations well and nor do they sufficiently capture the ozone transport patterns. Fully characterizing the importance of the nighttime ozone has been hampered by limited measurements of the vertical distribution of ozone and ozone-precursors. The main focus of this work is to begin to utilize remote sensing data sets to characterize the impact of nighttime aloft ozone to air quality events. We will describe our plans to use NASA satellite data sets, transport models and air quality models to study ozone transport, focusing primarily on nighttime ozone and provide initial results. We will use satellite and ozonesonde data to help understand how well the air quality models are simulating ozone in the lower free troposphere and attempt to characterize the impact of nighttime ozone to air quality events. Our specific objectives are: 1) Characterize nighttime aloft ozone using remote sensing data and sondes. 2) Evaluate the ability of the Community Multi-scale Air Quality (CMAQ) model and the National Air Quality Forecast Capability (NAQFC) model to capture the nighttime aloft ozone and its relationship to air quality events. 3) Analyze a set of air quality events and determine the relationship of air quality events to the nighttime aloft ozone. We will achieve our objectives by utilizing the ozone profile data from the NASA Earth Observing System (EOS) Tropospheric Emission Spectrometer (TES) and other sensors, ozonesonde data collected during the Aura mission (IONS), EPA AirNow ground station ozone data, the CMAQ continental-scale air quality model, and the National Air Quality Forecast model.

Transiting Exoplanet Studies and Community Targets for JWST's Early Release Science Program

NASA Astrophysics Data System (ADS)

Stevenson, Kevin B.; Lewis, Nikole K.; Bean, Jacob L.; Beichman, Charles; Fraine, Jonathan; Kilpatrick, Brian M.; Krick, J. E.; Lothringer, Joshua D.; Mandell, Avi M.; Valenti, Jeff A.; Agol, Eric; Angerhausen, Daniel; Barstow, Joanna K.; Birkmann, Stephan M.; Burrows, Adam; Charbonneau, David; Cowan, Nicolas B.; Crouzet, Nicolas; Cubillos, Patricio E.; Curry, S. M.; Dalba, Paul A.; de Wit, Julien; Deming, Drake; Désert, Jean-Michel; Doyon, René; Dragomir, Diana; Ehrenreich, David; Fortney, Jonathan J.; García Muñoz, Antonio; Gibson, Neale P.; Gizis, John E.; Greene, Thomas P.; Harrington, Joseph; Heng, Kevin; Kataria, Tiffany; Kempton, Eliza M.-R.; Knutson, Heather; Kreidberg, Laura; Lafrenière, David; Lagage, Pierre-Olivier; Line, Michael R.; Lopez-Morales, Mercedes; Madhusudhan, Nikku; Morley, Caroline V.; Rocchetto, Marco; Schlawin, Everett; Shkolnik, Evgenya L.; Shporer, Avi; Sing, David K.; Todorov, Kamen O.; Tucker, Gregory S.; Wakeford, Hannah R.

2016-09-01

The James Webb Space Telescope (JWST) will likely revolutionize transiting exoplanet atmospheric science, due to a combination of its capability for continuous, long duration observations and its larger collecting area, spectral coverage, and spectral resolution compared to existing space-based facilities. However, it is unclear precisely how well JWST will perform and which of its myriad instruments and observing modes will be best suited for transiting exoplanet studies. In this article, we describe a prefatory JWST Early Release Science (ERS) Cycle 1 program that focuses on testing specific observing modes to quickly give the community the data and experience it needs to plan more efficient and successful transiting exoplanet characterization programs in later cycles. We propose a multi-pronged approach wherein one aspect of the program focuses on observing transits of a single target with all of the recommended observing modes to identify and understand potential systematics, compare transmission spectra at overlapping and neighboring wavelength regions, confirm throughputs, and determine overall performances. In our search for transiting exoplanets that are well suited to achieving these goals, we identify 12 objects (dubbed “community targets”) that meet our defined criteria. Currently, the most favorable target is WASP-62b because of its large predicted signal size, relatively bright host star, and location in JWST's continuous viewing zone. Since most of the community targets do not have well-characterized atmospheres, we recommend initiating preparatory observing programs to determine the presence of obscuring clouds/hazes within their atmospheres. Measurable spectroscopic features are needed to establish the optimal resolution and wavelength regions for exoplanet characterization. Other initiatives from our proposed ERS program include testing the instrument brightness limits and performing phase-curve observations. The latter are a unique challenge compared to transit observations because of their significantly longer durations. Using only a single mode, we propose to observe a full-orbit phase curve of one of the previously characterized, short-orbital-period planets to evaluate the facility-level aspects of long, uninterrupted time-series observations.

Development of minimally invasive surgery for intractable epilepsy

NASA Astrophysics Data System (ADS)

Yamakawa, Takeshi

2009-04-01

Epilepsy is a chronic brain disorder characterized by recurrent seizures. The seizure is shot down by the surgical removal of the region which is so called "epileptogenc focus". However, the accuracy to detect the focus is not good (order of cm). Thus the extirpation of focus with significant margin causes the removal of normal brain and leads to the severe aftereffects such as restricted vision, motor dysfunction, disorder of memory, and so on. To cope with this problem, we should develop the technology of (1) detecting the epileptogenic focus, and (2) necrotizing the epileptogenic focus excluding normal brain by (a) colliquative necrosis with flash freezing and melting or (b) cauterizing by focused laser beam.

A hybrid framework for reservoir characterization using fuzzy ranking and an artificial neural network

NASA Astrophysics Data System (ADS)

Wang, Baijie; Wang, Xin; Chen, Zhangxin

2013-08-01

Reservoir characterization refers to the process of quantitatively assigning reservoir properties using all available field data. Artificial neural networks (ANN) have recently been introduced to solve reservoir characterization problems dealing with the complex underlying relationships inherent in well log data. Despite the utility of ANNs, the current limitation is that most existing applications simply focus on directly implementing existing ANN models instead of improving/customizing them to fit the specific reservoir characterization tasks at hand. In this paper, we propose a novel intelligent framework that integrates fuzzy ranking (FR) and multilayer perceptron (MLP) neural networks for reservoir characterization. FR can automatically identify a minimum subset of well log data as neural inputs, and the MLP is trained to learn the complex correlations from the selected well log data to a target reservoir property. FR guarantees the selection of the optimal subset of representative data from the overall well log data set for the characterization of a specific reservoir property; and, this implicitly improves the modeling and predication accuracy of the MLP. In addition, a growing number of industrial agencies are implementing geographic information systems (GIS) in field data management; and, we have designed the GFAR solution (GIS-based FR ANN Reservoir characterization solution) system, which integrates the proposed framework into a GIS system that provides an efficient characterization solution. Three separate petroleum wells from southwestern Alberta, Canada, were used in the presented case study of reservoir porosity characterization. Our experiments demonstrate that our method can generate reliable results.

Recycling of polymeric fraction of cable waste by rotational moulding.

PubMed

Díaz, Sara; Ortega, Zaida; McCourt, Mark; Kearns, Mark P; Benítez, Antonio N

2018-06-01

This study focuses on the mechanical recycling of polymeric waste that is produced in considerable amount from the cable industry. Every year large amounts of cables become waste; wires recycling has traditionally focused on metal recovery, while the polymer cover has just been considered as a residue, being landfilled or incinerated. Nowadays, increasingly restrictive regulations and concern about environment make necessary to reduce landfilling as much as possible. Main novelty of the study is that the material used in the research is a post-consumer material and the entire residual material is used, without a previous purification, in contrast with similar studies. Characterization of this residue was performed by thermal analysis, showing that the material is mainly made up of a heavy fraction (84% of the residue), which is not able to melt, fact what makes recycling more difficult. Once characterized, the material was ground, blended with virgin polyethylene and reprocessed by rotational moulding. The influence of the amount of residue and parts structure (1, 2 and 3 layers) was assessed, studying the mechanical behaviour of obtained parts (tensile, flexural and impact properties). It has been found that although mechanical properties get reduced with the increased amount of residue, up to a 35% of residue can be used without an important decrease in mechanical properties. On the other hand, the use of multiple layers in the mouldings allowed obtaining a better external appearance without compromising the mechanical properties. Copyright © 2018 Elsevier Ltd. All rights reserved.

Genotype-by-sequencing of the plant-pathogenic fungi Pyrenophora teres and Sphaerulina musiva utilizing Ion Torrent sequence technology

USDA-ARS?s Scientific Manuscript database

The characterization of genes determining compatibility or incompatibility between plant pathogenic fungi and their hosts is important for the management of crop disease. The major focus of these interactions has typically been the identification and characterization of host genes, but it is equally...

CHARACTERIZATION OF SULFUR CONTAINING ANALOGS OF MONOMETHYLARSONIC ACID IN AQUEOUS PHASE STANDARDS AND CARROT EXTRACTS BY IC-ICP-MS AND IC-ESI-MS/MS

EPA Science Inventory

Recently, sulfur analogs of well known arsenicals have been identified, generating a need for stable species-specific standards. This presentation will focus on the identification and characterization of a novel species, monomethylthioarsonic acid (MMTA), in carrots. A standard...

Influence of the segmentation on the characterization of cerebral networks of structural damage for patients with disorders of consciousness

NASA Astrophysics Data System (ADS)

Martínez, Darwin; Mahalingam, Jamuna J.; Soddu, Andrea; Franco, Hugo; Lepore, Natasha; Laureys, Steven; Gómez, Francisco

2015-01-01

Disorders of consciousness (DOC) are a consequence of a variety of severe brain injuries. DOC commonly results in anatomical brain modifications, which can affect cortical and sub-cortical brain structures. Postmortem studies suggest that severity of brain damage correlates with level of impairment in DOC. In-vivo studies in neuroimaging mainly focus in alterations on single structures. Recent evidence suggests that rather than one, multiple brain regions can be simultaneously affected by this condition. In other words, DOC may be linked to an underlying cerebral network of structural damage. Recently, geometrical spatial relationships among key sub-cortical brain regions, such as left and right thalamus and brain stem, have been used for the characterization of this network. This approach is strongly supported on automatic segmentation processes, which aim to extract regions of interests without human intervention. Nevertheless, patients with DOC usually present massive structural brain changes. Therefore, segmentation methods may highly influence the characterization of the underlying cerebral network structure. In this work, we evaluate the level of characterization obtained by using the spatial relationships as descriptor of a sub-cortical cerebral network (left and right thalamus) in patients with DOC, when different segmentation approaches are used (FSL, Free-surfer and manual segmentation). Our results suggest that segmentation process may play a critical role for the construction of robust and reliable structural characterization of DOC conditions.

Space-time windowing of angle-beam wavefield data to characterize scattering from defects

NASA Astrophysics Data System (ADS)

Weng, Yu; Michaels, Jennifer E.

2018-04-01

The primary focus of ultrasonic nondestructive evaluation is defect detection and characterization. In particular, fatigue cracks emanating from fastener holes are commonly found in aerospace structures. Therefore, scattering of ultrasonic waves from crack-like notches is of practical interest. Here, angle-beam shear waves are used to interrogate notches in aluminum plates. In prior work, notch-scattering was characterized and quantified in the frequency-wavenumber domain, which has the undesirable effect of lumping all scattered shear wave energy from notches into a single energy curve. This present work focuses on developing space-time windowing methods to quantify notch-scattered energy directly in the time-space domain. Two strategies are developed. The first is to indirectly characterize notch-scattering via the change in scattering as compared to the undamaged through-hole. The second strategy is to directly track notch-scattered waves in the time-space domain and then quantify scattered energy by constructing energy-versus-direction curves. Both strategies provide a group of energy difference curves, which show how notch-scattering evolves as time progresses. Notch-scattering quantification results for different notch lengths are shown and discussed.

Implementation of focused ion beam (FIB) system in characterization of nuclear fuels and materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

A. Aitkaliyeva; J. W. Madden; B. D. Miller

2014-10-01

Beginning in 2007, a program was established at the Idaho National Laboratory to update key capabilities enabling microstructural and micro-chemical characterization of highly irradiated and/or radiologically contaminated nuclear fuels and materials at scales that previously had not been achieved for these types of materials. Such materials typically cannot be contact handled and pose unique hazards to instrument operators, facilities, and associated personnel. One of the first instruments to be acquired was a Dual Beam focused ion beam (FIB)-scanning electron microscope (SEM) to support preparation of transmission electron microscopy and atom probe tomography samples. Over the ensuing years, techniques have beenmore » developed and operational experience gained that has enabled significant advancement in the ability to characterize a variety of fuel types including metallic, ceramic, and coated particle fuels, obtaining insights into in-reactor degradation phenomena not obtainable by any other means. The following article describes insights gained, challenges encountered, and provides examples of unique results obtained in adapting Dual Beam FIB technology to nuclear fuels characterization.« less

Characterization of the Los Alamos IPG YLR-6000 fiber laser using multiple optical paths and laser focusing optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milewski, John O; Bernal, John E

2009-01-01

Fiber laser technology has been identified as the replacement power source for the existing Los Alamos TA-55 production laser welding system. An IPG YLR-6000 fiber laser was purchased, installed at SM-66 R3, and accepted in February 2008. No characterization of the laser and no welding was performed in the Feb 2008 to May 2009 interval. T. Lienert and J. Bernal (Ref. 1, July 2009) determined the existing 200 mm Rofin collimator and focus heads used with the Rofin diode pumped lasers were inadequate for use with the IPG laser due to clipping of the IPG laser beam. Further efforts inmore » testing of the IPG laser with Optoskand fiber delivery optics and a Rofin 120 mm collimator proved problematic due to optical fiber damage. As a result, IPG design optical fibers were purchased as replacements for subsequent testing. Within the same interval, an IPG fiber-to-fiber (F2F) connector, custom built for LANL, (J. Milewski, S. Gravener, Ref.2) was demonstrated and accepted at IPG Oxford, MA in August 2009. An IPG service person was contracted to come to LANL to assist in the installation, training, troubleshooting and characterization of the multiple beam paths and help perform laser head optics characterization. The statement of work is provided below: In summary the laser system, optical fibers, F2F connector, Precitec head, and a modified Rofin type (w/120mm Optoskand collimator) IWindowIBoot system focus head (Figure 1) were shown to perform well at powers up to 6 kW CW. Power measurements, laser spot size measurements, and other characterization data and lessons learned are contained within this report. In addition, a number of issues were identified that will require future resolution.« less

Explaining Autism: Ten Reasons to Focus on the Developing Self

ERIC Educational Resources Information Center

Hobson, R. Peter

2010-01-01

My aim in this paper is to present reasons for adopting a focus on the development of self/other-awareness when characterizing the developmental psychopathology of autism. The strengths of such a position include an emphasis on children's emotional relations with embodied persons as foundational for their growing understanding of minds. I give…

Families in Focus: New Perspectives on Mothers, Fathers, and Children.

ERIC Educational Resources Information Center

Bruce, Judith; And Others

Noting that although families have always been characterized by change, there is strong evidence that they are changing faster today than ever before. This book focuses on the changing roles of mothers, fathers, and children, emphasizing how fathers and mothers meet parental responsibilities and what children have a right to expect from their…

DebriSat Fragment Characterization System and Processing Status

NASA Technical Reports Server (NTRS)

Rivero, M.; Shiotani, B.; M. Carrasquilla; Fitz-Coy, N.; Liou, J. C.; Sorge, M.; Huynh, T.; Opiela, J.; Krisko, P.; Cowardin, H.

2016-01-01

The DebriSat project is a continuing effort sponsored by NASA and DoD to update existing break-up models using data obtained from hypervelocity impact tests performed to simulate on-orbit collisions. After the impact tests, a team at the University of Florida has been working to characterize the fragments in terms of their mass, size, shape, color and material content. The focus of the post-impact effort has been the collection of 2 mm and larger fragments resulting from the hypervelocity impact test. To date, in excess of 125K fragments have been recovered which is approximately 40K more than the 85K fragments predicted by the existing models. While the fragment collection activities continue, there has been a transition to the characterization of the recovered fragments. Since the start of the characterization effort, the focus has been on the use of automation to (i) expedite the fragment characterization process and (ii) minimize the effects of human subjectivity on the results; e.g., automated data entry processes were developed and implemented to minimize errors during transcription of the measurement data. At all steps of the process, however, there is human oversight to ensure the integrity of the data. Additionally, repeatability and reproducibility tests have been developed and implemented to ensure that the instrumentations used in the characterization process are accurate and properly calibrated.

Investigation of plant latices of Asteraceae and Campanulaceae regarding proteolytic activity.

PubMed

Sytwala, Sonja; Domsalla, André; Melzig, Matthias F

2015-12-01

Occurrence of plant latices is widespread, there are more than 40 families of plants characterized to establish lactiferous structures. The appearance of hydrolytic active proteins, incorporated in latices is already characterized, and hydrolytic active proteins are considerable, and for several plant families, the occurrence of hydrolytic active proteins is already specified e.g. Apocynaceae Juss., Caricaceae Dumort, Euphorbiaceae Juss., Moraceae Gaudich and Papaveraceae Juss. In our investigation, focused on latex bearing plants of order Asterales, Asteraceae and Campanulaceae in particular. The present outcomes represent a comprehensive study, relating to the occurrence of proteolytic active enzymes of order Asterales for the first time. 131 different species of Asteraceae and Campanulaceae were tested, and the appearance of plant latex proteases were determined in different quantities. Proteolytic activity was investigated by inhibitory studies and determination of residual activity in the following, enable us to characterize the proteases. Most of the considered species exhibit a serine protease activity and a multiplicity of species exhibited two or more subclasses of proteases. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Real-time chemical characterization of atmospheric particulate matter in China: A review

NASA Astrophysics Data System (ADS)

Li, Yong Jie; Sun, Yele; Zhang, Qi; Li, Xue; Li, Mei; Zhou, Zhen; Chan, Chak K.

2017-06-01

Atmospheric particulate matter (PM) pollution has become a major health threat accompanying the rapid economic development in China. For decades, filter-based offline chemical analyses have been the most widely adopted means to investigate PM and have provided much information for understanding this type of pollution in China. However, offline analyses have low time resolutions and the chemical information thus obtained fail to reflect the dynamic nature of the sources and the rapid processes leading to the severe PM pollution in China. In recent years, advances in real-time PM chemical characterization have created a new paradigm for PM studies in China. In this review, we summarize those advances, focusing on the most widely used mass spectrometric and ion chromatographic techniques. We describe the findings from those studies in terms of spatiotemporal variabilities, degree of neutralization and oxygenation, source apportionment, secondary formation, as well as collocated measurements of the chemical and physical (hygroscopic and optical) properties of PM. We also highlight the new insights gained from those findings and suggest future directions for further advancing our understanding of PM pollution in China via real-time chemical characterization.

Wastes as Aggregates, Binders or Additions in Mortars: Selecting Their Role Based on Characterization.

PubMed

Farinha, Catarina Brazão; de Brito, Jorge; Veiga, Rosário; Fernández, J M; Jiménez, J R; Esquinas, A R

2018-03-20

The production of waste has increased over the years and, lacking a recycle or recovery solution, it is forwarded to landfill. The incorporation of wastes in cement-based materials is a solution to reduce waste deposition. In this regard, some researchers have been studying the incorporation of wastes with different functions: aggregate, binder and addition. The incorporation of wastes should take advantage of their characteristics. It requires a judicious analysis of their particles. This research involves the analysis of seven industrial wastes: biomass ashes, glass fibre, reinforced polymer dust, sanitary ware, fluid catalytic cracking, acrylic fibre, textile fibre and glass fibre. The main characteristics and advantages of each waste are enunciated and the best type of introduction in mortars is discussed. The characterization of the wastes as particles is necessary to identify the most suitable incorporation in mortars. In this research, some wastes are studied with a view to their re-use or recycling in mortars. Thus, this research focuses on the chemical, physical and mechanical characterization of industrial wastes and identification of the potentially most advantageous type of incorporation.

Proteins in olive fruit and oil.

PubMed

Montealegre, Cristina; Esteve, Clara; García, Maria Concepción; García-Ruiz, Carmen; Marina, Maria Luisa

2014-01-01

This paper is a comprehensive review grouping the information on the extraction, characterization, and quantitation of olive and olive oil proteins and providing a practical guide about these proteins. Most characterized olive proteins are located in the fruit, mainly in the seed, where different oleosins and storage proteins have been found. Unlike the seed, the olive pulp contains a lower protein content having been described a polypeptide of 4.6 kDa and a thaumain-like protein. Other important proteins studied in olive fruits have been enzymes which could play important roles in olives characteristics. Part of these proteins is transferred from the fruit to the oil during the manufacturing process of olive oil. In fact, the same polypeptide of 4.6 kDa found in the pulp has been described in the olive oil and, additionally, the presence of other proteins and enzymes have also been described. Protein profiles have recently been proposed as an interesting strategy for the varietal classification of olive fruits and oils. Nevertheless, there is still a lot of knowledge without being explored requiring new studies focused on the determination and characterization of these proteins.

Wastes as Aggregates, Binders or Additions in Mortars: Selecting Their Role Based on Characterization

PubMed Central

de Brito, Jorge; Veiga, Rosário

2018-01-01

The production of waste has increased over the years and, lacking a recycle or recovery solution, it is forwarded to landfill. The incorporation of wastes in cement-based materials is a solution to reduce waste deposition. In this regard, some researchers have been studying the incorporation of wastes with different functions: aggregate, binder and addition. The incorporation of wastes should take advantage of their characteristics. It requires a judicious analysis of their particles. This research involves the analysis of seven industrial wastes: biomass ashes, glass fibre, reinforced polymer dust, sanitary ware, fluid catalytic cracking, acrylic fibre, textile fibre and glass fibre. The main characteristics and advantages of each waste are enunciated and the best type of introduction in mortars is discussed. The characterization of the wastes as particles is necessary to identify the most suitable incorporation in mortars. In this research, some wastes are studied with a view to their re-use or recycling in mortars. Thus, this research focuses on the chemical, physical and mechanical characterization of industrial wastes and identification of the potentially most advantageous type of incorporation. PMID:29558418

Methods for coherent lensless imaging and X-ray wavefront measurements

NASA Astrophysics Data System (ADS)

Guizar Sicairos, Manuel

X-ray diffractive imaging is set apart from other high-resolution imaging techniques (e.g. scanning electron or atomic force microscopy) for its high penetration depth, which enables tomographic 3D imaging of thick samples and buried structures. Furthermore, using short x-ray pulses, it enables the capability to take ultrafast snapshots, giving a unique opportunity to probe nanoscale dynamics at femtosecond time scales. In this thesis we present improvements to phase retrieval algorithms, assess their performance through numerical simulations, and develop new methods for both imaging and wavefront measurement. Building on the original work by Faulkner and Rodenburg, we developed an improved reconstruction algorithm for phase retrieval with transverse translations of the object relative to the illumination beam. Based on gradient-based nonlinear optimization, this algorithm is capable of estimating the object, and at the same time refining the initial knowledge of the incident illumination and the object translations. The advantages of this algorithm over the original iterative transform approach are shown through numerical simulations. Phase retrieval has already shown substantial success in wavefront sensing at optical wavelengths. Although in principle the algorithms can be used at any wavelength, in practice the focus-diversity mechanism that makes optical phase retrieval robust is not practical to implement for x-rays. In this thesis we also describe the novel application of phase retrieval with transverse translations to the problem of x-ray wavefront sensing. This approach allows the characterization of the complex-valued x-ray field in-situ and at-wavelength and has several practical and algorithmic advantages over conventional focused beam measurement techniques. A few of these advantages include improved robustness through diverse measurements, reconstruction from far-field intensity measurements only, and significant relaxation of experimental requirements over other beam characterization approaches. Furthermore, we show that a one-dimensional version of this technique can be used to characterize an x-ray line focus produced by a cylindrical focusing element. We provide experimental demonstrations of the latter at hard x-ray wavelengths, where we have characterized the beams focused by a kinoform lens and an elliptical mirror. In both experiments the reconstructions exhibited good agreement with independent measurements, and in the latter a small mirror misalignment was inferred from the phase retrieval reconstruction. These experiments pave the way for the application of robust phase retrieval algorithms for in-situ alignment and performance characterization of x-ray optics for nanofocusing. We also present a study on how transverse translations help with the well-known uniqueness problem of one-dimensional phase retrieval. We also present a novel method for x-ray holography that is capable of reconstructing an image using an off-axis extended reference in a non-iterative computation, greatly generalizing an earlier approach by Podorov et al. The approach, based on the numerical application of derivatives on the field autocorrelation, was developed from first mathematical principles. We conducted a thorough theoretical study to develop technical and intuitive understanding of this technique and derived sufficient separation conditions required for an artifact-free reconstruction. We studied the effects of missing information in the Fourier domain, and of an imperfect reference, and we provide a signal-to-noise ratio comparison with the more traditional approach of Fourier transform holography. We demonstrated this new holographic approach through proof-of-principle optical experiments and later experimentally at soft x-ray wavelengths, where we compared its performance to Fourier transform holography, iterative phase retrieval and state-of-the-art zone-plate x-ray imaging techniques (scanning and full-field). Finally, we present a demonstration of the technique using a single 20 fs pulse from a high-harmonic table-top source. Holography with an extended reference is shown to provide fast, good quality images that are robust to noise and artifacts that arise from missing information due to a beam stop. (Abstract shortened by UMI.)

A random phased-array for MR-guided transcranial ultrasound neuromodulation in non-human primates

NASA Astrophysics Data System (ADS)

Chaplin, Vandiver; Phipps, Marshal A.; Caskey, Charles F.

2018-05-01

Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human primates at 650 kHz. The array is randomized with 128 elements 6.6 mm in diameter, radius of curvature 7.2 cm, opening diameter 10.3 cm (focal ratio 0.7), and 46% coverage. Simulations were used to optimize transducer geometry with respect to focus size, grating lobes, and directivity. Focus size and grating lobes during electronic steering were quantified using hydrophone measurements in water and a three-axis stage. A novel combination of optical tracking and acoustic mapping enabled measurement of the 3D pressure distribution in the cortical region of an ex vivo skull to within ~3.5 mm of the surface, and allowed accurate modelling of the experiment via non-homogeneous 3D acoustic simulations. The data demonstrates acoustic focusing beyond the skull bone, with the focus slightly broadened and shifted proximal to the skull. The fabricated design is capable of targeting regions within the S1 sensorimotor cortex of macaques.

A random phased-array for MR-guided transcranial ultrasound neuromodulation in non-human primates.

PubMed

Chaplin, Vandiver; Phipps, Marshal A; Caskey, Charles F

2018-05-17

Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human primates at 650 kHz. The array is randomized with 128 elements 6.6 mm in diameter, radius of curvature 7.2 cm, opening diameter 10.3 cm (focal ratio 0.7), and 46% coverage. Simulations were used to optimize transducer geometry with respect to focus size, grating lobes, and directivity. Focus size and grating lobes during electronic steering were quantified using hydrophone measurements in water and a three-axis stage. A novel combination of optical tracking and acoustic mapping enabled measurement of the 3D pressure distribution in the cortical region of an ex vivo skull to within ~3.5 mm of the surface, and allowed accurate modelling of the experiment via non-homogeneous 3D acoustic simulations. The data demonstrates acoustic focusing beyond the skull bone, with the focus slightly broadened and shifted proximal to the skull. The fabricated design is capable of targeting regions within the S1 sensorimotor cortex of macaques.

Sub-500  nm hard x ray focusing by compound long kinoform lenses.

PubMed

Liao, Keliang; Liu, Jing; Liang, Hao; Wu, Xuehui; Zhang, Kai; Yuan, Qingxi; Yi, Futing; Sheng, Weifan

2016-01-01

The focusing performance of polymethyl methacrylate compound long kinoform lenses with 70 μm aperture and 19.5 mm focal length was characterized with 8 keV x rays using the knife-edge scan method at the 4W1A transmission x-ray microscope beamline of Beijing Synchrotron Radiation Facility. The experiment result shows a best FWHM focus size of 440 nm with 31% diffraction efficiency.

How Person-Organization Fit Impacts Employees' Perceptions of Justice and Well-Being

PubMed Central

Roczniewska, Marta; Retowski, Sylwiusz; Higgins, E. Tory

2018-01-01

Regulatory fit theory predicts that when individuals adopt strategies that sustain their motivational orientations, they feel right about what is happening. Our aim was to test these predictions at the person-organization level. Across three studies, we expected and found that a feeling right experience that results from a match between an employee and an organizational climate produces perceptions that the company's prevailing procedures are fair. In Study 1 (N = 300), a survey among employees of distinct companies, we observed that the more organizational characteristics matched individual promotion and prevention focus of the employees, the more the employees perceived their workplace as just. Study 2 (N = 139), a randomized-control experiment, replicated this pattern by demonstrating that individuals with a predominant promotion focus assigned fairness to the organizational conduct most strongly when they recalled events characterizing a promotion-oriented environment; on the contrary, individuals with a predominant prevention focus deemed their workplace most fair when they were asked to recall prevention-related conduct of their company. In Study 3 (N = 376), a cross-sectional field study, we found that regulatory non-fit was associated with lower procedural justice perceptions and this, in turn, related to higher burnout. Theoretical and practical implications of applying regulatory fit theory to person-organization relationships are discussed. PMID:29375436

Studies Of Coherent Synchrotron Radiation And Longitudinal Space Charge In The Jefferson Lab FEL Driver

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tennant, Christopher D.; Douglas, David R.; Li, Rui

2014-12-01

The Jefferson Laboratory IR FEL Driver provides an ideal test bed for studying a variety of beam dynamical effects. Recent studies focused on characterizing the impact of coherent synchrotron radiation (CSR) with the goal of benchmarking measurements with simulation. Following measurements to characterize the beam, we quantitatively characterized energy extraction via CSR by measuring beam position at a dispersed location as a function of bunch compression. In addition to operating with the beam on the rising part of the linac RF waveform, measurements were also made while accelerating on the falling part. For each, the full compression point was movedmore » along the backleg of the machine and the response of the beam (distribution, extracted energy) measured. Initial results of start-to-end simulations using a 1D CSR algorithm show remarkably good agreement with measurements. A subsequent experiment established lasing with the beam accelerated on the falling side of the RF waveform in conjunction with positive momentum compaction (R56) to compress the bunch. The success of this experiment motivated the design of a modified CEBAF-style arc with control of CSR and microbunching effects.« less

A Comprehensive Approach Towards Optimizing the Xenon Plasma Focused Ion Beam Instrument for Semiconductor Failure Analysis Applications.

PubMed

Subramaniam, Srinivas; Huening, Jennifer; Richards, John; Johnson, Kevin

2017-08-01

The xenon plasma focused ion beam instrument (PFIB), holds significant promise in expanding the applications of focused ion beams in new technology thrust areas. In this paper, we have explored the operational characteristics of a Tescan FERA3 XMH PFIB instrument with the aim of meeting current and future challenges in the semiconductor industry. A two part approach, with the first part aimed at optimizing the ion column and the second optimizing specimen preparation, has been undertaken. Detailed studies characterizing the ion column, optimizing for high-current/high mill rate activities, have been described to support a better understanding of the PFIB. In addition, a novel single-crystal sacrificial mask method has been developed and implemented for use in the PFIB. Using this combined approach, we have achieved high-quality images with minimal artifacts, while retaining the shorter throughput times of the PFIB. Although the work presented in this paper has been performed on a specific instrument, the authors hope that these studies will provide general insight to direct further improvement of PFIB design and applications.

Preliminary Studies of Ions Emission in a Small Plasma Focus Device of Hundreds of Joules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreno, Jose; Pavez, Cristian; Soto, Leopoldo

2009-01-21

Ion beam emission in plasma focus (PF) discharges was originally investigated to explain the strong forward anisotropy observed in the neutron. Several properties of PF emitted deuteron beams have been measured, including their angular distributions and energy spectra in devices operating with energies from 1 kJ to 1 MJ. At present there is a growing interest in the development of very small PF devices operating under 1 kJ. As part of the characterization program of the very low energy PF devices (<1 kJ) developed at the Chilean Nuclear Energy Commission, the charges particle emission in hydrogen (H{sub 2}) and mixturemore » (H{sub 2}+%Ar) are being studied. In order to obtain an estimation of the ions energy spectrum and ionization grade, by using time of flight method, a graphite collector system operating in the bias ion collector mode was constructed and it is being used. Preliminary results of the ion beams measurements in different experimental conditions, at a plasma focus device of 400 joules (PF-400 J) are presented.« less

Codes over infinite family of rings : Equivalence and invariant ring

NASA Astrophysics Data System (ADS)

Irwansyah, Muchtadi-Alamsyah, Intan; Muchlis, Ahmad; Barra, Aleams; Suprijanto, Djoko

2016-02-01

In this paper, we study codes over the ring Bk=𝔽pr[v1,…,vk]/(vi2=vi,∀i =1 ,…,k ) . For instance, we focus on two topics, i.e. characterization of the equivalent condition between two codes over Bk using a Gray map into codes over finite field 𝔽pr, and finding generators for invariant ring of Hamming weight enumerator for Euclidean self-dual codes over Bk.

All the Missiles Work: Technological Dislocations and Military Innovation: A Case Study in US Air Force Air-to-Air Armament, Post-World War II through Operation Rolling Thunder

DTIC Science & Technology

2015-01-01

technological momentum attempted to reconcile two of the disparate perspectives???social constructivism and technological determinism . The theory of...perspectives—social constructivism and technological determinism . The theory of technological dislocations advanced by this thesis is a refinement of...constructivism to technological determinism is unidirectional.114 His theory therefore tends to focus historical analysis on characterizing the

'They Won't Take You as a Man, as a Real Man' Why Men Can't Teach Young Children in Foundation Phase

ERIC Educational Resources Information Center

Moosa, Shaaista; Bhana, Deevia

2018-01-01

This article focuses on how male and female primary school teachers' account of the suitability of male teachers in early years or Foundation Phase (FP) of schooling. We draw from an in-depth qualitative interview-based study to examine how ideals around hegemonic masculinity have effects for the characterization of FP within traditional feminine…

Multiphoton microscopic imaging of fibrotic focus in invasive ductal carcinoma of the breast

NASA Astrophysics Data System (ADS)

Chen, Sijia; Nie, Yuting; Lian, Yuane; Wu, Yan; Fu, Fangmeng; Wang, Chuan; Zhuo, Shuangmu; Chen, Jianxin

2014-11-01

During the proliferation of breast cancer, the desmoplastic can evoke a fibrosis response by invading healthy tissue. Fibrotic focus (FF) in invasive ductal carcinoma (IDC) of the breast had been reported to be associated with significantly poorer survival rate than IDC without FF. As an important prognosis indicator, it's difficult to obtain the exact fibrotic information from traditional detection method such as mammography. Multiphoton imaging based on two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG) has been recently employed for microscopic examination of unstained tissue. In this study, multiphoton microscopy (MPM) was used to image the fibrotic focus in invasive ductal carcinoma tissue. The morphology and distribution of collagen in fibrotic focus can be demonstrated by the SHG signal. Variation of collagen between IDC with and without FF will be examined and further characterized, which may be greatly related to the metastasis of breast cancer. Our result suggested that the MPM can be efficient in identifying and locating the fibrotic focus in IDC. Combining with the pathology analysis and other detecting methods, MPM owns potential in becoming an advanced histological tool for detecting the fibrotic focus in IDC and collecting prognosis information, which may guide the subsequent surgery option and therapy procedure for patients.

A neutron scattering study on the stability of trehalose mycolates under thermal stress

NASA Astrophysics Data System (ADS)

Migliardo, F.; Salmeron, C.; Bayan, N.

2013-10-01

The present paper is focused on the study of the dynamics of mycolic acids, which are fundamental components of the outer membrane (mycomembrane) of Mycobacterium tuberculosis. An elastic neutron scattering study of mycolic acid/H2O and lecithin/H2O mixtures as a function of temperature and exchanged wavevector Q has been carried out. This study provides an effective way for characterizing the dynamical properties, furnishing a set of parameters characterizing the different flexibility and rigidity of the investigated lipids. The behavior of the elastically scattered intensity profiles and the derived mean square displacements as a function of temperature shows a more marked temperature dependence for lecithin lipids in comparison with mycolic acids, so revealing a higher thermal stability of these latter. These findings could be useful for understanding the dynamics-function relation in the mycomembrane and then to relate it to the low permeability and high resistance of mycobacteria to many antibiotics.

Microstructural Study of Micron-Sized Craters Simulating Stardust Impacts in Aluminum 1100 Targets

NASA Technical Reports Server (NTRS)

Leroux, Hugues; Borg, Janet; Troadec, David; Djouadi, Zahia; Horz, Friedrich

2006-01-01

Various microscopic techniques were used to characterize experimental micro- craters in aluminium foils to prepare for the comprehensive analysis of the cometary and interstellar particle impacts in aluminium foils to be returned by the Stardust mission. First, SEM (Scanning Electron Microscopy) and EDS (Energy Dispersive X-ray Spectroscopy) were used to study the morphology of the impact craters and the bulk composition of the residues left by soda-lime glass impactors. A more detailed structural and compositional study of impactor remnants was then performed using TEM (Transmission Electron Microscopy), EDS, and electron diffraction methods. The TEM samples were prepared by Focused Ion Beam (FIB) methods. This technique proved to be especially valuable in studying impact crater residues and impact crater morphology. Finally, we also showed that InfraRed microscopy (IR) can be a quick and reliable tool for such investigations. The combination of all of these tools enables a complete microscopic characterization of the craters.

Electrochemical Performance and Microbial Characterization of Thermophilic Microbial Fuel Cells

NASA Astrophysics Data System (ADS)

Wrighton, K. C.; Agbo, P.; Brodie, E. L.; Weber, K. A.; Desantis, T. Z.; Anderson, G. L.; Coates, J. D.

2007-12-01

Significant research effort is currently focused on microbial fuel cells (MFC) as a source of renewable energy. To date, most of these efforts have concentrated on MFCs operating at mesophilic temperatures. However, many previous studies have reported on the superiority of thermophilic conditions in anaerobic digestion and demonstrated a net gain in energy yield, in terms of methane, relative to the increased energy requirements of operation. Because of this, our recent studies on MFCs focused on investigating the operation and microbiology associated with thermophilic MFCs operating at 55°C. Over 100-day operation, these MFCs were highly stable and achieved a maximum power density of 24mW/m2 and a columbic efficiency of 89 percent with acetate as the sole electron donor. In order to characterize the microbial community involved in thermophilic electricity generation, DNA and RNA were isolated from the electrode and PhyloChip analyses performed. Exploring the changes in the microbial community over time in electricity producing MFC revealed an increase in relative abundance of populations belonging to the Firmicutes, Chloroflexi, and alpha Proteobacteria by at least one order of magnitude. In contrast, these populations decreased in the open circuit and no electron donor amended controls. In order to better characterize the active microbial populations, we enriched and isolated a novel organism, strain JR, from samples collected from an operating MFC. Based on 16S rRNA sequence analysis strain JR was a member of the family Peptococcaceae, within the Phylum Firmicutes, clustering with Thermincola ferriacetica (98 percent similarity). Phenotypic characterization revealed that strain JR was capable of thermophilic dissimilatory reduction of insoluble electron acceptors such as amorphous Fe(III); as well as reduction of the model quinone 2,6-anthraquinone disulfonate. Thermincola strain JR was also capable of producing current by coupling acetate oxidation to anodic electron transfer. This represents the first organism isolated from a thermophilic microbial fuel cell and also the first representative of this genus capable of anodic electron transfer. The results of this study indicate the potential advantages for thermophilic MFCs and the novel microbiology associated with their operation.

Biodiversity of Archaea and floral of two inland saltern ecosystems in the Alto Vinalopó Valley, Spain

PubMed Central

2010-01-01

Background The extraction of salt from seawater by means of coastal solar salterns is a very well-described process. Moreover, the characterization of these environments from ecological, biochemical and microbiological perspectives has become a key focus for many research groups all over the world over the last 20 years. In countries such as Spain, there are several examples of coastal solar salterns (mainly on the Mediterranean coast) and inland solar salterns, from which sodium chloride is obtained for human consumption. However, studies focused on the characterization of inland solar salterns are scarce and both the archaeal diversity and the plant communities inhabiting these environments remain poorly described. Results Two of the inland solar salterns (termed Redonda and Penalva), located in the Alto Vinalopó Valley (Alicante, Spain), were characterized regarding their geological and physico-chemical characteristics and their archaeal and botanical biodiversity. A preliminary eukaryotic diversity survey was also performed using saline water. The chemical characterization of the brine has revealed that the salted groundwater extracted to fill these inland solar salterns is thalassohaline. The plant communities living in this environment are dominated by Sarcocornia fruticosa (L.) A.J. Scott, Arthrocnemum macrostachyum (Moris) K. Koch, Suaeda vera Forsk. ex Gmelin (Amaranthaceae) and several species of Limonium (Mill) and Tamarix (L). Archaeal diversity was analyzed and compared by polymerase chain reaction (PCR)-based molecular phylogenetic techniques. Most of the sequences recovered from environmental DNA samples are affiliated with haloarchaeal genera such as Haloarcula, Halorubrum, Haloquadratum and Halobacterium, and with an unclassified member of the Halobacteriaceae. The eukaryote Dunaliella was also present in the samples. Conclusions To our knowledge, this study constitutes the first analysis centered on inland solar salterns located in the southeastern region of Spain. The results obtained revealed that the salt deposits of this region have marine origins. Plant communities typical of salt marshes are present in this ecosystem and members of the Halobacteriaceae family can be easily detected in the microbial populations of these habitats. Possible origins of the haloarchaea detected in this study are discussed. PMID:20942947

Interpretation bias in Cluster-C and borderline personality disorders.

PubMed

Arntz, Arnoud; Weertman, Anoek; Salet, Sjoerd

2011-08-01

Cognitive therapy (CT) assumes that personality disorders (PDs) are characterized by interpretational biases that maintain the disorder. Changing interpretations is therefore a major aim of CT of PDs. This study tested whether Borderline PD (BPD), Avoidant and Dependent PD (AV/DEPD), and Obsessive-Compulsive PD (OCPD) are characterized by specific interpretations. Among the 122 participants there were 55 PD patients (17 BPD, 30 AV/DEPD, 29 OCPD diagnoses), 26 axis-1 patients, and 41 nonpatients. Participants put themselves into 10 scripts of negative events and noted feelings, thoughts and behaviors that came to mind. Next, they chose between hypothesized BPD-specific, AV/DEPD-specific, and OCPD-specific interpretations of each event (forced choice). Lastly, participants rated belief in each interpretation. Regression analyses revealed that forced choices and belief ratings supported the CT-model of BPD and AV/DEP: interpretations were specific. The alleged OCPD-beliefs were however not specifically related to OCPD, with relatively high popularity in axis-1 patients and nonpatients. The open responses were classified by judges blind for diagnoses, with the following results. BPD was characterized by low levels of solution-focused and healthy-flexible/accepting responses, and higher levels of criticizing others and malevolent interpretations of others. AV/DEPD was characterized by lower levels of solution-focused responses, and higher levels of self-criticism, negative emotions, guilt and fear of judgment, as well as lower levels of other-criticism. OCPD only showed trends for lower healthy responses, and higher compulsiveness and worry. It is concluded that the assumptions of CT are supported for BPD and AV/DEPD, but not - at least not on the explicit interpretational level - for OCPD. CT of OCPD might need a slightly different approach. Copyright © 2011 Elsevier Ltd. All rights reserved.

Characterizing Physician Listening Behavior During Hospitalist Handoffs using the HEAR Checklist

PubMed Central

Greenstein, Elizabeth A.; Arora, Vineet M.; Staisiunas, Paul G.; Banerjee, Stacy S.; Farnan, Jeanne M.

2015-01-01

Background The increasing fragmentation of healthcare has resulted in more patient handoffs. Many professional groups, including the Accreditation Council on Graduate Medical Education and the Society of Hospital Medicine, have made recommendations for safe and effective handoffs. Despite the two-way nature of handoff communication, the focus of these efforts has largely been on the person giving information. Objective To observe and characterize the listening behaviors of handoff receivers during hospitalist handoffs. Design Prospective observational study of shift change and service change handoffs on a non-teaching hospitalist service at a single academic tertiary care institution. Measurements The “HEAR Checklist”, a novel tool created based on review of effective listening behaviors, was used by third party observers to characterize active and passive listening behaviors and interruptions during handoffs. Results In 48 handoffs (25 shift change, 23 service change), active listening behaviors (e.g. read-back (17%), note-taking (23%), and reading own copy of the written signout (27%)) occurred less frequently than passive listening behaviors (e.g. affirmatory statements (56%) nodding (50%) and eye contact (58%)) (p<0.01). Read-back occurred only 8 times (17%). In 11 handoffs (23%) receivers took notes. Almost all (98%) handoffs were interrupted at least once, most often by side conversations, pagers going off, or clinicians arriving. Handoffs with more patients, such as service change, were associated with more interruptions (r= 0.46, p<0.01). Conclusions Using the “HEAR Checklist”, we can characterize hospitalist handoff listening behaviors. While passive listening behaviors are common, active listening behaviors that promote memory retention are rare. Handoffs are often interrupted, most commonly by side conversations. Future handoff improvement efforts should focus on augmenting listening and minimizing interruptions. PMID:23258389

Advanced mass spectrometry-based methods for the analysis of conformational integrity of biopharmaceutical products

PubMed Central

Bobst, Cedric E.; Kaltashov, Igor A.

2012-01-01

Mass spectrometry has already become an indispensable tool in the analytical armamentarium of the biopharmaceutical industry, although its current uses are limited to characterization of covalent structure of recombinant protein drugs. However, the scope of applications of mass spectrometry-based methods is beginning to expand to include characterization of the higher order structure and dynamics of biopharmaceutical products, a development which is catalyzed by the recent progress in mass spectrometry-based methods to study higher order protein structure. The two particularly promising methods that are likely to have the most significant and lasting impact in many areas of biopharmaceutical analysis, direct ESI MS and hydrogen/deuterium exchange, are focus of this article. PMID:21542797

Characterizing scientific production and consumption in Physics

PubMed Central

Zhang, Qian; Perra, Nicola; Gonçalves, Bruno; Ciulla, Fabio; Vespignani, Alessandro

2013-01-01

We analyze the entire publication database of the American Physical Society generating longitudinal (50 years) citation networks geolocalized at the level of single urban areas. We define the knowledge diffusion proxy, and scientific production ranking algorithms to capture the spatio-temporal dynamics of Physics knowledge worldwide. By using the knowledge diffusion proxy we identify the key cities in the production and consumption of knowledge in Physics as a function of time. The results from the scientific production ranking algorithm allow us to characterize the top cities for scholarly research in Physics. Although we focus on a single dataset concerning a specific field, the methodology presented here opens the path to comparative studies of the dynamics of knowledge across disciplines and research areas. PMID:23571320

Characterization and identification of a chymotryptic hydrolysate of alpha-lactalbumin stimulating cholecystokinin release in STC-1 cells.

PubMed

Catiau, Lucie; Delval-Dubois, Véronique; Guillochon, Didier; Nedjar-Arroume, Naïma

2011-11-01

Alpha-lactalbumin hydrolysate is of significant interest, due to its potential application as a source of bioactive peptides in nutraceutical and pharmaceutical domains. This study was focused on the cholecystokinin (CCK) family compounds which are small peptides involved in the satiety control. The action of chymotryptic hydrolysate of alpha-lactalbumin on cholecystokinin release from intestinal endocrine STC-1 cells was investigated. We demonstrated for the first time that a chymotryptic hydrolysate of alpha-lactalbumin was able to highly stimulate CCK-releasing activity from STC-1 cells. The peptidic hydrolysate was characterized by LC/MS and MS/MS, thus highlighting the presence of 11 fractions containing 21 peptides, each potentially having the desired activity.

The ethylene response pathway in Arabidopsis

NASA Technical Reports Server (NTRS)

Kieber, J. J.; Evans, M. L. (Principal Investigator)

1997-01-01

The simple gas ethylene influences a diverse array of plant growth and developmental processes including germination, senescence, cell elongation, and fruit ripening. This review focuses on recent molecular genetic studies, principally in Arabidopsis, in which components of the ethylene response pathway have been identified. The isolation and characterization of two of these genes has revealed that ethylene sensing involves a protein kinase cascade. One of these genes encodes a protein with similarity to the ubiquitous Raf family of Ser/Thr protein kinases. A second gene shows similarity to the prokaryotic two-component histidine kinases and most likely encodes an ethylene receptor. Additional elements involved in ethylene signaling have only been identified genetically. The characterization of these genes and mutants will be discussed.

Characterization of Acoustic Droplet Vaporization Using MRI

NASA Astrophysics Data System (ADS)

Li, David; Allen, Steven; Hernandez-Garcia, Luis; Bull, Joseph

2013-11-01

Acoustic droplet vaporization (ADV) is the selective vaporization of liquid droplets to form larger gas bubbles. The ADV process is currently being researched for biomedical applications such as gas embolotherapy, drug delivery, and phase-change contrast agents. In this study an albumin encapsulated dodecafluoropentane (DDFP, CAS: 678-26-2) microdroplet suspension was vaporized using a single element focused (f/2, D = 19 mm) 3.5 MHz transducer (Panametrics A321S, Olympus, Waltham, MA). The resulting DDFP bubble clouds were imaged using both bright field microscopy and MRI (Varian 7T, Agilent Technologies Inc., Santa Clara, CA). Field distortions due to DDFP bubble generation were characterized against the bright field images as a function of acoustic power and bubble cloud size. Experimentally a direct correlation between bubble cloud dimensions generated and field distortions seen in the MRI was observed. Additionally, MR velocimetry was used to measure the flow field resulting from ADV. The field distortions due to the bubbles were further characterized by modeling Maxwell's equations using COMSOL (COMSOL Inc., Burlington, MA). The ability to characterize ADV with alternative imaging modalities may prove useful in further development of ADV based biomedical therapies.

The rise of food allergy: Environmental factors and emerging treatments.

PubMed

Benedé, Sara; Blázquez, Ana Belen; Chiang, David; Tordesillas, Leticia; Berin, M Cecilia

2016-05-01

Food allergy has rapidly increased in prevalence, suggesting an important role for environmental factors in disease susceptibility. The immune response of food allergy is characterized by IgE production, and new findings from mouse and human studies indicate an important role of the cytokine IL-9, which is derived from both T cells and mast cells, in disease manifestations. Emerging evidence suggests that route of exposure to food, particularly peanut, is important. Exposure through the skin promotes sensitization while early exposure through the gastrointestinal tract promotes tolerance. Evidence from mouse studies indicate a role of the microbiome in development of food allergy, which is supported by correlative human studies showing a dysbiosis in food allergy. There is no approved treatment for food allergy, but emerging therapies are focused on allergen immunotherapy to provide desensitization, while pre-clinical studies are focused on using adjuvants or novel delivery approaches to improve efficacy and safety of immunotherapy. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair?

PubMed

Hutchinson, Ian D; Rodeo, Scott A; Perrone, Gabriel S; Murray, Martha M

2015-02-01

The use of platelet-rich plasma (PRP) to improve clinical outcome following a soft tissue injury, regeneration, and repair has been the subject of intense investigation and discussion. This article endeavors to relate clinical and basic science strategies focused on biological augmentation of the healing response in anterior cruciate ligament (ACL) and meniscus repair and replacement using PRP. Therein, a translational feedback loop is created in the literature and targeted towards the entire multidisciplinary team. Ultimately, it is hoped that the theoretical benefits of PRP on soft-tissue interfacial healing will emerge clinically following a careful, focused characterization at the benchtop, and prospective randomized controlled clinical study. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications

NASA Astrophysics Data System (ADS)

Geissner, Andreas; Seeberger, Peter H.

2016-06-01

A major branch of glycobiology and glycan-focused biomedicine studies the interaction between carbohydrates and other biopolymers, most importantly, glycan-binding proteins. Today, this research into glycan-biopolymer interaction is unthinkable without glycan arrays, tools that enable high-throughput analysis of carbohydrate interaction partners. Glycan arrays offer many applications in basic biochemical research, for example, defining the specificity of glycosyltransferases and lectins such as immune receptors. Biomedical applications include the characterization and surveillance of influenza strains, identification of biomarkers for cancer and infection, and profiling of immune responses to vaccines. Here, we review major applications of glycan arrays both in basic and applied research. Given the dynamic nature of this rapidly developing field, we focus on recent findings.

Intrinsic Fluctuations and Driven Response of Insect Swarms

NASA Astrophysics Data System (ADS)

Ni, Rui; Puckett, James G.; Dufresne, Eric R.; Ouellette, Nicholas T.

2015-09-01

Animals of all sizes form groups, as acting together can convey advantages over acting alone; thus, collective animal behavior has been identified as a promising template for designing engineered systems. However, models and observations have focused predominantly on characterizing the overall group morphology, and often focus on highly ordered groups such as bird flocks. We instead study a disorganized aggregation (an insect mating swarm), and compare its natural fluctuations with the group-level response to an external stimulus. We quantify the swarm's frequency-dependent linear response and its spectrum of intrinsic fluctuations, and show that the ratio of these two quantities has a simple scaling with frequency. Our results provide a new way of comparing models of collective behavior with experimental data.

Nanopore fabrication and characterization by helium ion microscopy

NASA Astrophysics Data System (ADS)

Emmrich, D.; Beyer, A.; Nadzeyka, A.; Bauerdick, S.; Meyer, J. C.; Kotakoski, J.; Gölzhäuser, A.

2016-04-01

The Helium Ion Microscope (HIM) has the capability to image small features with a resolution down to 0.35 nm due to its highly focused gas field ionization source and its small beam-sample interaction volume. In this work, the focused helium ion beam of a HIM is utilized to create nanopores with diameters down to 1.3 nm. It will be demonstrated that nanopores can be milled into silicon nitride, carbon nanomembranes, and graphene with well-defined aspect ratio. To image and characterize the produced nanopores, helium ion microscopy and high resolution scanning transmission electron microscopy were used. The analysis of the nanopores' growth behavior allows inferring on the profile of the helium ion beam.

Magmatic Mapping: A Suggested Methodology And Results From The Springerville Volcanic Field, East-Central Arizona, USA

NASA Astrophysics Data System (ADS)

Mnich, M.; Condit, C.

2016-12-01

The Springerville Volcanic Field (SVF), located in east-central Arizona, is one of the best-characterized basaltic monogenetic volcanic fields in the world, with it's expanse of over 3000 km2 now mapped in it's entirety as a result of recent efforts in 2010 and 2011. The methods used, called "magmatic mapping" (Condit, 2007), provide a standardized, volcanic unit focused approach to characterizing volcanic fields. This approach focuses on delineating contacts between flows, completely characterizing each flow, and placing them into a temporal framework. Results of magmatic mapping in the SVF now provide a comprehensive overview of the lifespan of the field, representing a unique resource, useful not only in studying the petrogenetic evolution of this field, but in serving as a template for comparing similar volcanic fields. On Earth, several fields pose a significant risk to population centers, though these hazards are often poorly understood due to long intervals between eruptions. On other planets, remote mapping can be greatly enhanced by comparing it with a well-studied terrestrial analog that has been analyzed in detail; an area with ever heightening necessity as high-resolution data is becoming increasingly available. In the SVF, olivine phyric lavas are most abundance (22% of volcanic outcrop), followed by diktytaxitic and olivine/plagioclase phyric flows. However, lithology will vary depending on when an eruption takes place in a volcanic fields lifecycle. On the whole, the SVF is younger to the east and younger lavas are dominantly more alkalic. These trends are also displayed within individual geographic divisions, many of which correspond to temporal-geographic clusters as defined by Condit and Connor (1996). The mapping methods and patterns in geochemistry, lithology and age progression within the SVF represent a unique template for which to base basaltic mapping.

Sequencing Larger Intact Proteins (30-70 kDa) with Activated Ion Electron Transfer Dissociation

NASA Astrophysics Data System (ADS)

Riley, Nicholas M.; Westphall, Michael S.; Coon, Joshua J.

2018-01-01

The analysis of intact proteins via mass spectrometry can offer several benefits to proteome characterization, although the majority of top-down experiments focus on proteoforms in a relatively low mass range (<30 kDa). Recent studies have focused on improving the analysis of larger intact proteins (up to 75 kDa), but they have also highlighted several challenges to be addressed. One major hurdle is the efficient dissociation of larger protein ions, which often to do not yield extensive fragmentation via conventional tandem MS methods. Here we describe the first application of activated ion electron transfer dissociation (AI-ETD) to proteins in the 30-70 kDa range. AI-ETD leverages infrared photo-activation concurrent to ETD reactions to improve sequence-informative product ion generation. This method generates more product ions and greater sequence coverage than conventional ETD, higher-energy collisional dissociation (HCD), and ETD combined with supplemental HCD activation (EThcD). Importantly, AI-ETD provides the most thorough protein characterization for every precursor ion charge state investigated in this study, making it suitable as a universal fragmentation method in top-down experiments. Additionally, we highlight several acquisition strategies that can benefit characterization of larger proteins with AI-ETD, including combination of spectra from multiple ETD reaction times for a given precursor ion, multiple spectral acquisitions of the same precursor ion, and combination of spectra from two different dissociation methods (e.g., AI-ETD and HCD). In all, AI-ETD shows great promise as a method for dissociating larger intact protein ions as top-down proteomics continues to advance into larger mass ranges. [Figure not available: see fulltext.

Phenotypic and molecular characterizations of Yersinia pestis isolates from Kazakhstan and adjacent regions.

PubMed

Lowell, Jennifer L; Zhansarina, Aigul; Yockey, Brook; Meka-Mechenko, Tatyana; Stybayeva, Gulnaz; Atshabar, Bakyt; Nekrassova, Larissa; Tashmetov, Rinat; Kenghebaeva, Kuralai; Chu, May C; Kosoy, Michael; Antolin, Michael F; Gage, Kenneth L

2007-01-01

Recent interest in characterizing infectious agents associated with bioterrorism has resulted in the development of effective pathogen genotyping systems, but this information is rarely combined with phenotypic data. Yersinia pestis, the aetiological agent of plague, has been well defined genotypically on local and worldwide scales using multi-locus variable number tandem repeat analysis (MLVA), with emphasis on evolutionary patterns using old isolate collections from countries where Y. pestis has existed the longest. Worldwide MLVA studies are largely based on isolates that have been in long-term laboratory culture and storage, or on field material from parts of the world where Y. pestis has potentially circulated in nature for thousands of years. Diversity in these isolates suggests that they may no longer represent the wild-type organism phenotypically, including the possibility of altered pathogenicity. This study focused on the phenotypic and genotypic properties of 48 Y. pestis isolates collected from 10 plague foci in and bordering Kazakhstan. Phenotypic characterization was based on diagnostic tests typically performed in reference laboratories working with Y. pestis. MLVA was used to define the genotypic relationships between the central-Asian isolates and a group of North American isolates, and to examine Kazakh Y. pestis diversity according to predefined plague foci and on an intermediate geographical scale. Phenotypic properties revealed that a large portion of this collection lacks one or more plasmids necessary to complete the blocked flea/mammal transmission cycle, has lost Congo red binding capabilities (Pgm-), or both. MLVA analysis classified isolates into previously identified biovars, and in some cases groups of isolates collected within the same plague focus formed a clade. Overall, MLVA did not distinguish unique phylogeographical groups of Y. pestis isolates as defined by plague foci and indicated higher genetic diversity among older biovars.

[Epidemiologic and clinical study of paragonimosis in Cameroon. Results of niclofolan treatment].

PubMed

Ripert, C; Carrie, J; Ambroise-Thomas, P; Baecher, R; Kum, N P; Same-Ekobo, A

1981-01-01

Paragonimiasis does not occur only in the South West Province of Cameroon. Four foci exist in the country. They are the well known focus in the Mount Kupe area, the Mbam focus, the Nyong focus and the Ntem focus. All of them are located in the rainforest within the distribution area of Potadoma. This disease, characterized by the presence of eggs in sputum and feces, has often been confused with tuberculosis. In the villages where paragonimiasis is diagnosed by means of parasitological techniques circulating antibodies, revealed with a P. westermani antigen (ELISA), are often found in blood specimens taken from inhabitants. Teen agers suffer the most from the disease and females more often than males. Women and children are traditionally concerned with crabs fishing and they eat them after partly raw. Crabs of the genus Sudanautes contain the infective metacercariae. Paragonimiasis is enzootic and the civet cat V. civetta seems to be the main natural definitive host in Cameroon. Niclofolan given orally in a single dose of 2 mg/kg body weight showed a 100% cure rate. Side reactions are mild and transient.

The impact of information technology and organizational focus on the visibility of patient care errors.

PubMed

Walston, Stephen L; Mwachofi, Ari; Aldosari, Bakheet; Al-Omar, Badran A; Yousef, Asmaa Al; Sheikh, Asiya

2010-01-01

INVESTIGATED: The implementation of information systems and the creation of an open culture, characterized by emphasis on patient safety and problem solving, are 2 means suggested to improve health care quality. This study examines the effects of use of information technology and focus on patient safety and problem solving on the visibility of patient care errors. A survey of nurses in Saudi Arabia is analyzed by means of factor analysis and multiregression analysis to examine nurses' use of information technology and culture in controlling errors. Our research suggests that greater use of information technology to control patient care errors may reduce the prevalence of such errors while an increased focus on patient safety and problem solving facilitates an open environment where errors can be more openly discussed and addressed. The use of technology appears to have a role in decreasing errors. Yet, an organization that focuses on problem solving and patient safety can open lines of communication and create a culture in which errors can be discussed and resolved.

Characterizing Sorghum Panicles using 3D Point Clouds

NASA Astrophysics Data System (ADS)

Lonesome, M.; Popescu, S. C.; Horne, D. W.; Pugh, N. A.; Rooney, W.

2017-12-01

To address demands of population growth and impacts of global climate change, plant breeders must increase crop yield through genetic improvement. However, plant phenotyping, the characterization of a plant's physical attributes, remains a primary bottleneck in modern crop improvement programs. 3D point clouds generated from terrestrial laser scanning (TLS) and unmanned aerial systems (UAS) based structure from motion (SfM) are a promising data source to increase the efficiency of screening plant material in breeding programs. This study develops and evaluates methods for characterizing sorghum (Sorghum bicolor) panicles (heads) in field plots from both TLS and UAS-based SfM point clouds. The TLS point cloud over experimental sorghum field at Texas A&M farm in Burleston County TX were collected using a FARO Focus X330 3D laser scanner. SfM point cloud was generated from UAS imagery captured using a Phantom 3 Professional UAS at 10m altitude and 85% image overlap. The panicle detection method applies point cloud reflectance, height and point density attributes characteristic of sorghum panicles to detect them and estimate their dimensions (panicle length and width) through image classification and clustering procedures. We compare the derived panicle counts and panicle sizes with field-based and manually digitized measurements in selected plots and study the strengths and limitations of each data source for sorghum panicle characterization.

Transmission Kikuchi diffraction and transmission electron forescatter imaging of electropolished and FIB manufactured TEM specimens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zieliński, W., E-mail: wiziel@inmat.pw.edu.pl; Płociński, T.; Kurzydłowski, K.J.

2015-06-15

We present a study of the efficiency of the utility of scanning electron microscope (SEM)-based transmission methods for characterizing grain structure in thinned bulk metals. Foils of type 316 stainless steel were prepared by two methods commonly used for transmission electron microscopy — double-jet electropolishing and focused ion beam milling. A customized holder allowed positioning of the foils in a configuration appropriate for both transmission electron forward scatter diffraction, and for transmission imaging by the use of a forescatter detector with two diodes. We found that both crystallographic orientation maps and dark-field transmitted images could be obtained for specimens preparedmore » by either method. However, for both methods, preparation-induced artifacts may affect the quality or accuracy of transmission SEM data, especially those acquired by the use of transmission Kikuchi diffraction. Generally, the quality of orientation data was better for specimens prepared by electropolishing, due to the absence of ion-induced damage. - Highlights: • The transmission imaging and diffraction techniques are emerging in scanning electron microscopy (SEM) as promising new field of materials characterization. • The manuscript titled: “Transmission Kikuchi Diffraction and Transmission Electron Forescatter Imaging of Electropolished and FIB Manufactured TEM Specimens” documents how different specimen thinning procedures can effect efficiency of transmission Kikuchi diffraction and transmission electron forescatter imaging. • The abilities to make precision crystallographic orientation maps and dark-field images in transmission was studied on electropolished versus focus ion beam manufactured TEM specimens. • Depending on the need, electropolished and focused ion beam technique may produce suitable specimens for transmission imaging and diffraction in SEM.« less

Image analysis of skin color heterogeneity focusing on skin chromophores and the age-related changes in facial skin.

PubMed

Kikuchi, Kumiko; Masuda, Yuji; Yamashita, Toyonobu; Kawai, Eriko; Hirao, Tetsuji

2015-05-01

Heterogeneity with respect to skin color tone is one of the key factors in visual perception of facial attractiveness and age. However, there have been few studies on quantitative analyses of the color heterogeneity of facial skin. The purpose of this study was to develop image evaluation methods for skin color heterogeneity focusing on skin chromophores and then characterize ethnic differences and age-related changes. A facial imaging system equipped with an illumination unit and a high-resolution digital camera was used to develop image evaluation methods for skin color heterogeneity. First, melanin and/or hemoglobin images were obtained using pigment-specific image-processing techniques, which involved conversion from Commission Internationale de l'Eclairage XYZ color values to melanin and/or hemoglobin indexes as measures of their contents. Second, a spatial frequency analysis with threshold settings was applied to the individual images. Cheek skin images of 194 healthy Asian and Caucasian female subjects were acquired using the imaging system. Applying this methodology, the skin color heterogeneity of Asian and Caucasian faces was characterized. The proposed pigment-specific image-processing techniques allowed visual discrimination of skin redness from skin pigmentation. In the heterogeneity analyses of cheek skin color, age-related changes in melanin were clearly detected in Asian and Caucasian skin. Furthermore, it was found that the heterogeneity indexes of hemoglobin were significantly higher in Caucasian skin than in Asian skin. We have developed evaluation methods for skin color heterogeneity by image analyses based on the major chromophores, melanin and hemoglobin, with special reference to their size. This methodology focusing on skin color heterogeneity should be useful for better understanding of aging and ethnic differences. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Toward an Interdisciplinary Understanding of Sensory Dysfunction in Autism Spectrum Disorder: An Integration of the Neural and Symptom Literatures

PubMed Central

Schauder, Kimberly B.; Bennetto, Loisa

2016-01-01

Sensory processing differences have long been associated with autism spectrum disorder (ASD), and they have recently been added to the diagnostic criteria for the disorder. The focus on sensory processing in ASD research has increased substantially in the last decade. This research has been approached from two different perspectives: the first focuses on characterizing the symptoms that manifest in response to real world sensory stimulation, and the second focuses on the neural pathways and mechanisms underlying sensory processing. The purpose of this paper is to integrate the empirical literature on sensory processing in ASD from the last decade, including both studies characterizing sensory symptoms and those that investigate neural response to sensory stimuli. We begin with a discussion of definitions to clarify some of the inconsistencies in terminology that currently exist in the field. Next, the sensory symptoms literature is reviewed with a particular focus on developmental considerations and the relationship of sensory symptoms to other core features of the disorder. Then, the neuroscience literature is reviewed with a focus on methodological approaches and specific sensory modalities. Currently, these sensory symptoms and neuroscience perspectives are largely developing independently from each other leading to multiple, but separate, theories and methods, thus creating a multidisciplinary approach to sensory processing in ASD. In order to progress our understanding of sensory processing in ASD, it is now critical to integrate these two research perspectives and move toward an interdisciplinary approach. This will inevitably aid in a better understanding of the underlying biological basis of these symptoms and help realize the translational value through its application to early identification and treatment. The review ends with specific recommendations for future research to help bridge these two research perspectives in order to advance our understanding of sensory processing in ASD. PMID:27378838

"My child and I are a package deal": balancing adult and child concerns in repartnering after divorce.

PubMed

Anderson, Edward R; Greene, Shannon M

2011-10-01

Parents who repartner after divorce must decide how to balance the potentially competing demands of their own desire for adult companionship and romance with the needs of their children for parental attention and affection. In this study, the authors assessed individual differences in divorced custodial mothers' orientation toward repartnering, characterizing it as a continuum, ranging from more child focused to more adult focused. Mothers who are more adult focused tend to be older, more educated, more likely to be employed outside the home, and exiting marriages of longer duration. In addition, using longitudinal data from in-home interviews, mothers who are more adult focused reported having lower rapport with their children, spending less time in joint activities with their children, and their children in turn reported lower rapport with their mothers. Levels of adult-focused orientation are relatively stable over time but increase when mothers become involved or interested in new partners. Using longitudinal diary data over a 2-year period, the authors demonstrated that mothers who are more child focused engage in more active management of emergent relationships in repartnered families and that adult-focused and child-focused mothers respond to different concerns. Whereas all mothers become more active in managing emergent relationships when both partner and child are resisting one another, mothers with greater child focus respond more to concerns of the child, and mothers with greater adult focus respond more to the concerns of the partner. Implications for intervention with divorced families are discussed.

Undergraduate research studies program at participating institutions of the HBCU fossil energy consortium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhatia, S.C.; Cardelino, B.H.; Hall, J.H. Jr.

1990-04-30

The objectives of this research program are to expose students in minority institutions to energy and fossil fuels research, to stimulate their interest in the sciences and engineering, and to encourage them to pursue graduate studies, thereby ensuring the necessary supply of manpower for the industrial and energy sectors of the national economy. This report describes a project focused on the surface chemical properties of coal and their influence on the adsorption of aqueous soluble catalyst metals, and research on the characterization of coal liquids. 2 refs., 1 fig.

A case study in bifurcation theory

NASA Astrophysics Data System (ADS)

Khmou, Youssef

This short paper is focused on the bifurcation theory found in map functions called evolution functions that are used in dynamical systems. The most well-known example of discrete iterative function is the logistic map that puts into evidence bifurcation and chaotic behavior of the topology of the logistic function. We propose a new iterative function based on Lorentizan function and its generalized versions, based on numerical study, it is found that the bifurcation of the Lorentzian function is of second-order where it is characterized by the absence of chaotic region.

Characterizing the Use of Mathematical Knowledge in Boundary-Crossing Situations at Work

ERIC Educational Resources Information Center

Kent, Phillip; Noss, Richard; Guile, David; Hoyles, Celia; Bakker, Arthur

2007-01-01

The first aim of this article is to present a characterization of the techno-mathematical literacies needed for effective practice in modern, technology-rich workplaces that are both highly automated and increasingly focused on flexible response to customer needs. The second aim is to introduce an epistemological dimension to activity theory,…

Initial characterization of unidentified Armillaria isolate from Serbia using LSU-IGS1 and TEF-1a genes

Treesearch

N. Keca; N. B. Klopfenstein; M.-S. Kim; H. Solheim; S. Woodward

2014-01-01

Armillaria species have a global distribution and play variable ecological roles, including causing root disease of diverse forest, ornamental and horticultural trees. Accurate identification of Armillaria species is critical to understand their distribution and ecological roles. This work focused on characterizing an unidentified Armillaria isolate from a Serbian...

On the Constitutive Response Characterization for Composite Materials Via Data-Driven Design Optimization

Treesearch

John G. Michopoulos; John G. Hermanson; Athanasios lliopoulos; Samuel Lambrakos; Tomonari Furukawa

2011-01-01

In the present paper we focus on demonstrating the use of design optimization for the constitutive characterization of anisotropic material systems such as polymer matrix composites, with or without damage. All approaches are based on the availability of experimental data originating from mechatronic material testing systems that can expose specimens to...

Landscape characterization integrating expert and local spatial knowledge of land and forest resources.

PubMed

Fagerholm, Nora; Käyhkö, Niina; Van Eetvelde, Veerle

2013-09-01

In many developing countries, political documentation acknowledges the crucial elements of participation and spatiality for effective land use planning. However, operative approaches to spatial data inclusion and representation in participatory land management are often lacking. In this paper, we apply and develop an integrated landscape characterization approach to enhance spatial knowledge generation about the complex human-nature interactions in landscapes in the context of Zanzibar, Tanzania. We apply an integrated landscape conceptualization as a theoretical framework where the expert and local knowledge can meet in spatial context. The characterization is based on combining multiple data sources in GIS, and involves local communities and their local spatial knowledge since the beginning into the process. Focusing on the expected information needs for community forest management, our characterization integrates physical landscape features and retrospective landscape change data with place-specific community knowledge collected through participatory GIS techniques. The characterization is established in a map form consisting of four themes and their synthesis. The characterization maps are designed to support intuitive interpretation, express the inherently uncertain nature of the data, and accompanied by photographs to enhance communication. Visual interpretation of the characterization mediates information about the character of areas and places in the studied local landscape, depicting the role of forest resources as part of the landscape entity. We conclude that landscape characterization applied in GIS is a highly potential tool for participatory land and resource management, where spatial argumentation, stakeholder communication, and empowerment are critical issues.

Landscape Characterization Integrating Expert and Local Spatial Knowledge of Land and Forest Resources

NASA Astrophysics Data System (ADS)

Fagerholm, Nora; Käyhkö, Niina; Van Eetvelde, Veerle

2013-09-01

In many developing countries, political documentation acknowledges the crucial elements of participation and spatiality for effective land use planning. However, operative approaches to spatial data inclusion and representation in participatory land management are often lacking. In this paper, we apply and develop an integrated landscape characterization approach to enhance spatial knowledge generation about the complex human-nature interactions in landscapes in the context of Zanzibar, Tanzania. We apply an integrated landscape conceptualization as a theoretical framework where the expert and local knowledge can meet in spatial context. The characterization is based on combining multiple data sources in GIS, and involves local communities and their local spatial knowledge since the beginning into the process. Focusing on the expected information needs for community forest management, our characterization integrates physical landscape features and retrospective landscape change data with place-specific community knowledge collected through participatory GIS techniques. The characterization is established in a map form consisting of four themes and their synthesis. The characterization maps are designed to support intuitive interpretation, express the inherently uncertain nature of the data, and accompanied by photographs to enhance communication. Visual interpretation of the characterization mediates information about the character of areas and places in the studied local landscape, depicting the role of forest resources as part of the landscape entity. We conclude that landscape characterization applied in GIS is a highly potential tool for participatory land and resource management, where spatial argumentation, stakeholder communication, and empowerment are critical issues.

Spatial-spectral characterization of focused spatially chirped broadband laser beams.

PubMed

Greco, Michael J; Block, Erica; Meier, Amanda K; Beaman, Alex; Cooper, Samuel; Iliev, Marin; Squier, Jeff A; Durfee, Charles G

2015-11-20

Proper alignment is critical to obtain the desired performance from focused spatially chirped beams, for example in simultaneous spatial and temporal focusing (SSTF). We present a simple technique for inspecting the beam paths and focusing conditions for the spectral components of a broadband beam. We spectrally resolve the light transmitted past a knife edge as it was scanned across the beam at several axial positions. The measurement yields information about spot size, M2, and the propagation paths of different frequency components. We also present calculations to illustrate the effects of defocus aberration on SSTF beams.

Perspectives on Child Abuse and Labour: Global Ethical Ideals Versus African Cultural Realities

ERIC Educational Resources Information Center

Ajayi, A. O.; Torimiro, D. O.

2004-01-01

This article focuses on the global and African postures on the issues of child abuse and child labour. The global ethical ideals of the issues are characterized within their various theoretical perspectives while the African cultural realities are explored through the use of focus group discussion sessions, which were organized in six rural…

Decentering: A Construct to Analyze and Explain Teacher Actions as They Relate to Student Thinking

ERIC Educational Resources Information Center

Teuscher, Dawn; Moore, Kevin C.; Carlson, Marilyn P.

2016-01-01

Mathematics educators and writers of mathematics education policy documents continue to emphasize the importance of teachers focusing on and using student thinking to inform their instructional decisions and interactions with students. In this paper, we characterize the interactions between a teacher and student(s) that exhibit this focus.…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bukh, Boris; Lund, Steven M.

We present an analysis of envelope perturbations evolving in the limit of a fully space-charge depressed (zero emittance) beam in periodic, thin-lens focusing channels. Both periodic solenoidal and FODO quadrupole focusing channels are analyzed. The phase advance and growth rate of normal mode perturbations are analytically calculated as a function of the undepressed particle phase advance to characterize the evolution of envelope perturbations.

Mentoring for Diversity and Equity: Focusing on Students of Color and New Teachers of Color

ERIC Educational Resources Information Center

Achinstein, Betty

2012-01-01

The task of preparing and supporting new teachers for working with diverse youth has generated widespread interest in induction and mentoring programs (Wang & Odell, 2002). However, much of mentoring in practice falls short of equity- and diversity-focused work. It can be better characterized as "situational adjustment, technical advice, and…

Molecular identification and characterization of ileal and cecal fungus communities in broilers given probiotics, specific essential oil blends, and under mixed Eimeria infection

USDA-ARS?s Scientific Manuscript database

Broiler digestive tract fungal communities have gained far less scrutiny than that given corresponding bacterial communities. Attention given poultry-associated fungi have focused primarily on feed-associated toxin-producers, yeast, and yeast products. The current project focused on the use of pyr...

Coupled Thermo-Mechanical and Photo-Chemical Degradation Mechanisms that determine the Reliability and Operational Lifetimes for CPV Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dauskardt, Reinhold H.

This project sought to identify and characterize the coupled intrinsic photo-chemo-mechanical degradation mechanisms that determine the reliability and operational lifetimes for CPV technologies. Over a three year period, we have completed a highly successful program which has developed quantitative metrologies and detailed physics-based degradation models, providing new insight into the fundamental reliability physics necessary for improving materials, creating accelerated testing protocols, and producing more accurate lifetime predictions. The tasks for the program were separated into two focus areas shown in the figure below. Focus Area 1, led by Reinhold Dauskardt and Warren Cai with a primary collaboration with David Millermore » of NREL, studied the degradation mechanisms present in encapsulant materials. Focus Area 2, led by Reinhold Dauskardt and Ryan Brock with a primary collaboration with James Ermer and Peter Hebert of Spectrolab, studied stress development and degradation within internal CPV device interfaces. Each focus area was productive, leading to several publications, including findings on the degradation of silicone encapsulant under terrestrial UV, a model for photodegradation of silicone encapsulant adhesion, quantification and process tuning of antireflective layers on CPV, and discovery of a thermal cycling degradation mechanism present in metal gridline structures.« less

Technical know-how relevant to planning of borehole investigation for fault characterization

NASA Astrophysics Data System (ADS)

Mizuno, T.; Takeuchi, R.; Tsuruta, T.; Matsuoka, T.; Kunimaru, T.; Saegusa, H.

2011-12-01

As part of the national R&D program for geological disposal of high-level radioactive waste (HLW), the broad scientific study of the deep geological environment, JAEA has established the Mizunami Underground Research Laboratory (MIU) in Central Japan as a generic underground research laboratory (URL) facility. The MIU Project focuses on the crystalline rocks. In the case of fractured rock, a fault is one of the major discontinuity structures which control the groundwater flow conditions. It is important to estimate geological, hydrogeological, hydrochemical and rock mechanical characteristics of faults, and then to evaluate its role in the engineering design of repository and the assessment of long-term safety of HLW disposal. Therefore, investigations for fault characterization have been performed to estimate its characteristics and to evaluate existing conceptual and/or numerical models of the geological environment in the MIU project. Investigations related to faults have been conducted based on the conventional concept that a fault consists of a "fault core (FC)" characterized by distribution of the faulted rocks and a "fractured zone (FZ)" along FC. With the progress of investigations, furthermore, it is clear that there is also a case in which an "altered zone (AZ)" characterized by alteration of host rocks to clay minerals can be developed around the FC. Intensity of alteration in AZ generally decreases with distance from the FC, and AZ transits to FZ. Therefore, the investigation program focusing on properties of AZ is required for revising the existing conceptual and/or numerical models of geological environment. In this study, procedures for planning of fault characterizations have been summarized based on the technical know-how learnt through the MIU Project for the development of Knowledge Management System performed by JAEA under a contract with the Ministry of Economy, Trade and Industry as part of its R&D supporting program for developing geological disposal technology in 2010. Taking into account the experience from the fault characterization in the MIU Project, an optimization procedure for investigation program is summarized as follows; 1) Definition of investigation aim, 2) Confirmation of current understanding of the geological environment, 3) Specification and prioritization of the data to be obtained 4) Selection of the methodology for obtaining the data, 5) Specification of sequence of the investigations, and 6) Establishment of drilling and casing program including optional cases and taking into account potential problems. Several geological conceptual models with uncertainty of geological structures were illustrated to define the investigation aim and to confirm the current uncertainties. These models were also available to establish optional cases by predicting the type and location of potential problems. The procedures and case study related to establishment of the investigation program are summarized in this study and can be available for site characterization works conducted by the implementing body (NUMO) in future candidate areas.

Characterization of particle hygroscopicity by Raman lidar: Selected case studies from the convective and orographically-induced precipitation study

NASA Astrophysics Data System (ADS)

Stelitano, Dario; Di Girolamo, Paolo; Summa, Donato

2013-05-01

The characterization of particle hygroscopicity has primary importance for climate monitoring and prediction. Model studies have demonstrated that relative humidity (RH) has a critical influence on aerosol climate forcing. Hygroscopic properties of aerosols influence particle size distribution and refractive index and hence their radiative effects. Aerosol particles tend to grow at large relative humidity values as a result of their hygroscopicity. Raman lidars with aerosol, water vapor and temperature measurement capability are potentially attractive tools for studying aerosol hygroscopicity as in fact they can provide continuous altitude-resolved measurements of particle optical, size and microphysical properties, as well as relative humidity, without perturbing the aerosols or their environment. Specifically, the University of Basilicata Raman lidar system (BASIL) considered for the present study, has the capability to perform all-lidar measurements of relative humidity based on the application of both the rotational and the vibrational Raman lidar techniques in the UV. BASIL was operational in Achern (Black Forest, Lat: 48.64° N, Long: 8.06° E, Elev.: 140 m) between 25 May and 30 August 2007 in the framework of the Convective and Orographically-induced Precipitation Study (COPS). The present analysis is focused on selected case studies characterized by the presence of different aerosol types with different hygroscopic behavior. The observed behavior, dependent upon aerosol composition, may range from hygrophobic to strongly hygroscopic.

Peptide sequences from the first Castoroides ohioensis skull and the utility of old museum collections for palaeoproteomics

PubMed Central

Schroeter, Elena R.; Feranec, Robert S.; Vashishth, Deepak

2016-01-01

Vertebrate fossils have been collected for hundreds of years and are stored in museum collections around the world. These remains provide a readily available resource to search for preserved proteins; however, the vast majority of palaeoproteomic studies have focused on relatively recently collected bones with a well-known handling history. Here, we characterize proteins from the nasal turbinates of the first Castoroides ohioensis skull ever discovered. Collected in 1845, this is the oldest museum-curated specimen characterized using palaeoproteomic tools. Our mass spectrometry analysis detected many collagen I peptides, a peptide from haemoglobin beta, and in vivo and diagenetic post-translational modifications. Additionally, the identified collagen I sequences provide enough resolution to place C. ohioensis within Rodentia. This study illustrates the utility of archived museum specimens for both the recovery of preserved proteins and phylogenetic analyses. PMID:27306052

Genome Editing for the Study of Cardiovascular Diseases.

PubMed

Chadwick, Alexandra C; Musunuru, Kiran

2017-03-01

The opportunities afforded through the recent advent of genome-editing technologies have allowed investigators to more easily study a number of diseases. The advantages and limitations of the most prominent genome-editing technologies are described in this review, along with potential applications specifically focused on cardiovascular diseases. The recent genome-editing tools using programmable nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9), have rapidly been adapted to manipulate genes in a variety of cellular and animal models. A number of recent cardiovascular disease-related publications report cases in which specific mutations are introduced into disease models for functional characterization and for testing of therapeutic strategies. Recent advances in genome-editing technologies offer new approaches to understand and treat diseases. Here, we discuss genome editing strategies to easily characterize naturally occurring mutations and offer strategies with potential clinical relevance.

Seminar: Developmental Dyslexia

PubMed Central

Peterson, Robin L.; Pennington, Bruce F.

2012-01-01

Summary Dyslexia is a neurodevelopmental disorder that is characterized by slow and inaccurate word recognition. Dyslexia has been found in every culture studied, and mounting evidence underscores cross-linguistic similarity in its neurobiological and neurocognitive bases. There has been considerable progress across levels of analysis in the last five years. At a neuropsychological level, the phonological theory remains the most compelling, though it is increasingly clear that phonological problems interact with other cognitive risk factors. At a neurobiological level, recent research confirms that dyslexia is characterized by dysfunction of the normal left hemisphere language network and also implicates abnormal white matter development. Studies accounting for reading experience demonstrate that many observed neural differences reflect causes rather than effects of dyslexia. At an etiologic risk level, six candidate genes have been identified, and there is evidence for gene by environment interaction. This review includes a focus on these and other recent developments. PMID:22513218

Development of chitosan/pluronic F108/polyethersulfone (PES) nanofiltration (NF) membrane for oily wastewater treatment

NASA Astrophysics Data System (ADS)

Hamzah, Norzakiah; Rohani, Rosiah; Hassan, Abdul Rahman; Sharifuddin, Syazrin Syima; Isa, Mohd Hafez Mohd

2018-06-01

This study discusses a new finding for nanofiltration membrane development using phase inversion technique whereby polyethersulfone (PES) polymer was added with surfactant and additive. This research focuses on the development of a membrane that is efficient in treating oily wastewater and reducing membrane's low permeation flux issues. Five PES nanofiltration membranes were synthesized with pluronic F108 surfactant and different amounts of chitosan additive for each formulation. Subsequently, the effect of adding surfactant and additive on membrane performance was studied. Results showed that the membrane with the optimal amount of chitosan gave the highest flux and the rejection of oily wastewater with up to 90%. In addition, Fourier transform-infrared (FTIR) spectroscopy technique was used to characterize and analyse the membrane's properties. Hence, the developed membranes were successfully characterized and proved to be a good treatment for oily wastewater.

Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity.

PubMed

Armario, Antonio; Nadal, Roser

2013-01-01

Despite the development of valuable new techniques (i.e., genetics, neuroimage) for the study of the neurobiological substrate of psychiatric diseases, there are strong limitations in the information that can be gathered from human studies. It is thus critical to develop appropriate animal models of psychiatric diseases to characterize their putative biological bases and the development of new therapeutic strategies. The present review tries to offer a general perspective and several examples of how individual differences in animals can contribute to explain differential susceptibility to develop behavioral alterations, but also emphasizes methodological problems that can lead to inappropriate or over-simplistic interpretations. A critical analysis of the approaches currently used could contribute to obtain more reliable data and allow taking full advantage of new and sophisticated technologies. The discussion is mainly focused on anxiety-like and to a lower extent on depression-like behavior in rodents.

Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity

PubMed Central

Armario, Antonio; Nadal, Roser

2013-01-01

Despite the development of valuable new techniques (i.e., genetics, neuroimage) for the study of the neurobiological substrate of psychiatric diseases, there are strong limitations in the information that can be gathered from human studies. It is thus critical to develop appropriate animal models of psychiatric diseases to characterize their putative biological bases and the development of new therapeutic strategies. The present review tries to offer a general perspective and several examples of how individual differences in animals can contribute to explain differential susceptibility to develop behavioral alterations, but also emphasizes methodological problems that can lead to inappropriate or over-simplistic interpretations. A critical analysis of the approaches currently used could contribute to obtain more reliable data and allow taking full advantage of new and sophisticated technologies. The discussion is mainly focused on anxiety-like and to a lower extent on depression-like behavior in rodents. PMID:24265618

Tools for phospho- and glycoproteomics of plasma membranes.

PubMed

Wiśniewski, Jacek R

2011-07-01

Analysis of plasma membrane proteins and their posttranslational modifications is considered as important for identification of disease markers and targets for drug treatment. Due to their insolubility in water, studying of plasma membrane proteins using mass spectrometry has been difficult for a long time. Recent technological developments in sample preparation together with important improvements in mass spectrometric analysis have facilitated analysis of these proteins and their posttranslational modifications. Now, large scale proteomic analyses allow identification of thousands of membrane proteins from minute amounts of sample. Optimized protocols for affinity enrichment of phosphorylated and glycosylated peptides have set new dimensions in the depth of characterization of these posttranslational modifications of plasma membrane proteins. Here, I summarize recent advances in proteomic technology for the characterization of the cell surface proteins and their modifications. In the focus are approaches allowing large scale mapping rather than analytical methods suitable for studying individual proteins or non-complex mixtures.

Acoustic characterization of high intensity focused ultrasound fields: A combined measurement and modeling approach

PubMed Central

Canney, Michael S.; Bailey, Michael R.; Crum, Lawrence A.; Khokhlova, Vera A.; Sapozhnikov, Oleg A.

2008-01-01

Acoustic characterization of high intensity focused ultrasound (HIFU) fields is important both for the accurate prediction of ultrasound induced bioeffects in tissues and for the development of regulatory standards for clinical HIFU devices. In this paper, a method to determine HIFU field parameters at and around the focus is proposed. Nonlinear pressure waveforms were measured and modeled in water and in a tissue-mimicking gel phantom for a 2 MHz transducer with an aperture and focal length of 4.4 cm. Measurements were performed with a fiber optic probe hydrophone at intensity levels up to 24 000 W∕cm2. The inputs to a Khokhlov–Zabolotskaya–Kuznetsov-type numerical model were determined based on experimental low amplitude beam plots. Strongly asymmetric waveforms with peak positive pressures up to 80 MPa and peak negative pressures up to 15 MPa were obtained both numerically and experimentally. Numerical simulations and experimental measurements agreed well; however, when steep shocks were present in the waveform at focal intensity levels higher than 6000 W∕cm2, lower values of the peak positive pressure were observed in the measured waveforms. This underrepresentation was attributed mainly to the limited hydrophone bandwidth of 100 MHz. It is shown that a combination of measurements and modeling is necessary to enable accurate characterization of HIFU fields. PMID:19062878

Ultrafast Beam Filamentation: Spatio-Temporal Characterization and Control

DTIC Science & Technology

2013-11-01

measurement of spectral phase[7]. The output of the laser passes through a BK7 plate set at a Brewster angle to clean up the polarization of the beam...at the focus of a lens . In this configuration, the pulse focuses temporally and spatially at the same time. We developed a theory for understanding...focus by shaping only the spatial phase of the starting beam. Finally, we showed for the first time that Kerr- lens modelocking can be achieved in a Ti

Micro-bridge defects: characterization and root cause analysis

NASA Astrophysics Data System (ADS)

Santoro, Gaetano; Van den Heuvel, Dieter; Braggin, Jennifer; Rosslee, Craig; Leray, Philippe J.; Cheng, Shaunee; Jehoul, Christiane; Schreutelkamp, Robert; Hillel, Noam

2010-03-01

Defect review of advanced lithography processes is becoming more and more challenging as feature sizes decrease. Previous studies using a defect review SEM on immersion lithography generated wafers have resulted in a defect classification scheme which, among others, includes a category for micro-bridges. Micro-bridges are small connections between two adjacent lines in photo-resist and are considered device killing defects. Micro-bridge rates also tend to increase as feature sizes decrease, making them even more important for the next technology nodes. Especially because micro-bridge defects can originate from different root causes, the need to further refine and split up the classification of this type of defect into sub groups may become a necessity. This paper focuses on finding the correlation of the different types of micro-bridge defects to a particular root cause based on a full characterization and root cause analysis of this class of defects, by using advanced SEM review capabilities like high quality imaging in very low FOV, Multi Perspective SEM Imaging (MPSI), tilted column and rotated stage (Tilt&Rotation) imaging and Focused Ion Beam (FIB) cross sectioning. Immersion lithography material has been mainly used to generate the set of data presented in this work even though, in the last part of the results, some EUV lithography data will be presented as part of the continuing effort to extend the micro-bridge defect characterization to the EUV technology on 40 nm technology node and beyond.

Tackling the Challenge of Deep Vadose Zone Remediation at the Hanford Site

NASA Astrophysics Data System (ADS)

Morse, J. G.; Wellman, D. M.; Gephart, R.

2010-12-01

The Central Plateau of the Hanford Site in Washington State contains some 800 waste disposal sites where 1.7 trillion liters of contaminated water was once discharged into the subsurface. Most of these sites received liquids from the chemical reprocessing of spent uranium fuel to recover plutonium. In addition, 67 single shell tanks have leaked or are suspected to have leaked 3.8 million liters of high alkali and aluminate rich cesium-contaminated liquids into the sediment. Today, this inventory of subsurface contamination contains an estimated 550,000 curies of radioactivity and 150 million kg (165,000 tons) of metals and hazardous chemicals. Radionuclides range from mobile 99Tc to more immobilized 137Cs, 241Am, uranium, and plutonium. A significant fraction of these contaminants likely remain within the deep vadose zone. Plumes of groundwater containing tritium, nitrate, 129I and other contaminants have migrated through the vadose zone and now extend outward from the Central Plateau to the Columbia River. During most of Hanford Site history, subsurface studies focused on groundwater monitoring and characterization to support waste management decisions. Deep vadose zone studies were not a priority because waste practices relied upon that zone to buffer contaminant releases into the underlying aquifer. Remediation of the deep vadose zone is now central to Hanford Site cleanup because these sediments can provide an ongoing source of contamination to the aquifer and therefore to the Columbia River. However, characterization and remediation of the deep vadose zone pose some unique challenges. These include sediment thickness; contaminant depth; coupled geohydrologic, geochemical, and microbial processes controlling contaminant spread; limited availability and effectiveness of traditional characterization tools and cleanup remedies; and predicting contaminant behavior and remediation performance over long time periods and across molecular to field scales. The U.S Department of Energy recognizes these challenges and is committed to a sustained, focused effort of continuing to apply existing technologies where feasible while investing and developing in new innovative, field-demonstrated capabilities supporting longer-term basic and applied research to establish the technical underpinning for solving intractable deep vadose zone problems and implementing final remedies. This approach will rely upon Multi-Project Teams focusing on coordinated projects across multiple DOE offices, programs, and site contractors plus the facilitation of basic and applied research investments through implementing a Deep Vadose Zone Applied Field Research Center and other scientific studies.

Lectin-Binding Specificity of the Fertilization-Relevant Protein PDC-109 by Means of Surface Plasmon Resonance and Carbohydrate REcognition Domain EXcision-Mass Spectrometry.

PubMed

Defaus, Sira; Avilés, Manuel; Andreu, David; Gutiérrez-Gallego, Ricardo

2018-04-04

Seminal plasma proteins are relevant for sperm functionality and some appear responsible for establishing sperm interactions with the various environments along the female genital tract towards the oocyte. In recent years, research has focused on characterizing the role of these proteins in the context of reproductive biology, fertility diagnostics and treatment of related problems. Herein, we focus on the main protein of bovine seminal plasma, PDC-109 (BSP-A1/-A2), which by virtue of its lectin properties is involved in fertilization. By means of surface plasmon resonance, the interaction of PDC-109 with a panel of the most relevant glycosidic epitopes of mammals has been qualitatively and quantitatively characterized, and a higher affinity for carbohydrates containing fucose has been observed, in line with previous studies. Additionally, using the orthogonal technique of Carbohydrate REcognition Domain EXcision-Mass Spectrometry (CREDEX-MS), the recognition domain of the interaction complexes between PDC-109 and all fucosylated disaccharides [(Fuc-α1,(3,4,6)-GlcNAc)] has been defined, revealing the specific glycotope and the peptide domain likely to act as the PDC-109 carbohydrate binding site.

Small scale mechanical characterization of thin foil materials via pin load microtesting

DOE PAGES

Wheeler, Robert; Pandey, Amit; Shyam, Amit; ...

2015-05-06

In situ scanning electron microscope (SEM) experiments, where small-scale mechanical tests are conducted on micro- and nanosized specimens, allow direct visualization of elastic and plastic responses over the entirety of the volume being deformed. This enables precise spatial and temporal correlation of slip events contributing to the plastic flow evidenced in a stress–strain curve. A new pin-loading methodology has been employed, in situ within the SEM, to conduct microtensile tests on thin polycrystalline metal foils. This approach can be tailored to a specific foil whose particular grain size may range from microns to tens of microns. Manufacture of the specializedmore » pin grip was accomplished via silicon photolithography-based processing followed by subsequent focused ion beam finishing. Microtensile specimen preparation was achieved by combining a stencil mask methodology employing broad ion beam sputtering along with focused ion beam milling in the study of several metallic foil materials. Finite-element analyses were performed to characterize the stress and strain distributions in the pin grip and micro-specimen under load. Furthermore, under appropriately conceived test conditions, uniaxial stress–strain responses measured within these foils by pin-load microtensile testing exhibit properties consistent with larger scale tests.« less

Are Barroom and Neighborhood Characteristics Independently Related to Local-Area Assaults?

PubMed

Morrison, Christopher; Mair, Christina F; Lee, Juliet P; Gruenewald, Paul J

2015-12-01

Two separate but complementary literatures examine bar-related violence: one has focused on barroom features, and the other has focused on features of neighborhoods near bars. This study unifies these 2 perspectives using a microenvironmental approach. In a purposive sample of 65 bars in 4 California cities, we used premise assessments to characterize the physical, social, and economic environments of barrooms (e.g., patron count, average pace of drinking, and restaurant service); and a combination of systematic social observation, census, and alcohol license data to characterize the neighborhoods in which they were located (e.g., physical disorder, alcohol outlet density, and median household income). Hierarchical Poisson models then assessed relationships between these features and counts of police-reported assaults within buffer areas around bars. Aspects of both barroom environments (more patrons, more dancing, and louder music) and neighborhood environments (greater bar density, greater physical disorder, lower population density, and lower income) were independently related to increased incidence of assaults. Preventive intervention to reduce bar-area violence may be directed at both bar environments (e.g., limiting the number of patrons) and neighborhood environments (e.g., limiting outlet density). Copyright © 2015 by the Research Society on Alcoholism.

Evaluation of natural foci of Panstrongylus megistus in a forest fragment in Porto Alegre, State of Rio Grande do Sul, Brazil.

PubMed

Santos, José Eloy Dos; Viola, Mariana Gubert; Lorosa, Elias Seixas; Machado, Evandro Marques de Menezes; Ruas Neto, Antonio Leite; Corseuil, Elio

2013-01-01

Panstrongylus megistus is commonly found in wild environments of the State of Rio Grande do Sul, Brazil. The aim of this study was to characterize the network of refuges used by triatomine in a forest fragment of Porto Alegre and to identify Trypanosoma cruzi infection, associated hosts and the epidemiological importance of both hosts and triatomines. Techniques including the spool-and-line method and active searching (transects) were used to identify natural foci. The food source for each triatomine was determined using the precipitin test, and the infection of marsupials was determined by xenodiagnosis. A total of 33 adults (domestic environment) and 27 nymphs (wild environment) of P. megistus were found in addition to 43 Didelphis albiventris specimens. The infection rates of triatomine adults, triatomine nymphs and opossums with T. cruzi I were 64%, 73% and 69%, respectively. Birds, rodents and opossums were the main resources used by triatomine. This work presents the first characterization of a natural focus of P. megistus in Rio Grande do Sul. The natural characteristics of this focus and its implication in the transmission of T. cruzi are discussed.

Hails from the crypt: a terror management health model investigation of the effectiveness of health-oriented versus celebrity-oriented endorsements.

PubMed

McCabe, Simon; Vail, Kenneth E; Arndt, Jamie; Goldenberg, Jamie L

2014-03-01

Interfacing the terror management health model with the meaning transfer model, we offer novel hypotheses concerning the effectiveness of celebrity and medical endorsements for consumer products and health behavior decisions. Studies 1 and 2 revealed that, compared with control topic primes, death thoughts in focal attention increased the effectiveness of health-oriented (doctor) endorsers but not culture-oriented (celebrity) endorsers, whereas death thoughts outside of focal attention increased the effectiveness of culture-oriented endorsers but not health-oriented endorsers. Studies 3 and 4 then focus more specifically on the valence and specificity of culture-oriented endorsements, revealing that death thoughts outside focal attention increase the effectiveness of culture-oriented endorsers only on the behaviors specifically endorsed and only when the endorser is characterized as possessing cultural value. Discussion focuses on everyday management of existential concerns and implications for persuasive communications in the health domain.

Long-Term Lunar Radiation Degradation Effects on Materials

NASA Technical Reports Server (NTRS)

Rojdev, Kristina; ORourke, Mary Jane; Koontz, Steve; Alred, John; Hill, Charles; Devivar, Rodrigo; Morera-Felix, Shakira; Atwell, William; Nutt, Steve; Sabbann, Leslie

2010-01-01

The National Aeronautics and Space Administration (NASA) is focused on developing technologies for extending human presence beyond low Earth orbit. These technologies are to advance the state-of-the-art and provide for longer duration missions outside the protection of Earth's magnetosphere. One technology of great interest for large structures is advanced composite materials, due to their weight and cost savings, enhanced radiation protection for the crew, and potential for performance improvements when compared with existing metals. However, these materials have not been characterized for the interplanetary space environment, and particularly the effects of high energy radiation, which is known to cause damage to polymeric materials. Therefore, a study focusing on a lunar habitation element was undertaken to investigate the integrity of potential structural composite materials after exposure to a long-term lunar radiation environment. An overview of the study results are presented, along with a discussion of recommended future work.

The influence of the work environment on cardiovascular health: a historical, conceptual, and methodological perspective.

PubMed

Kasl, S V

1996-01-01

The framework of psychosocial epidemiology is used to examine research developments that characterize the accumulation of knowledge regarding the role of the work environment in cardiovascular health and disease. The discussion of current programs of research focuses on the work of T. Theorell and R. Karasek (1996) and J. Siegrist (1996) as exemplars of European and American studies that have contributed the most to the understanding of occupational cardiovascular health. It is argued that researchers need to maintain and nurture relatively broad conceptual models of etiology because cardiovascular disease involves multiple biomedical risk factors and because specific aspects of the work environment are embedded in a large, complex matrix of other psychosocial influences. At the same time, investigators need to push ahead with focused research strategies to clarify the precise nature of the work environmental risk factors that emerge in the broad, somewhat imprecise epidemiologic study designs.

Evaluating focused ion beam patterning for position-controlled nanowire growth using computer vision

NASA Astrophysics Data System (ADS)

Mosberg, A. B.; Myklebost, S.; Ren, D.; Weman, H.; Fimland, B. O.; van Helvoort, A. T. J.

2017-09-01

To efficiently evaluate the novel approach of focused ion beam (FIB) direct patterning of substrates for nanowire growth, a reference matrix of hole arrays has been used to study the effect of ion fluence and hole diameter on nanowire growth. Self-catalyzed GaAsSb nanowires were grown using molecular beam epitaxy and studied by scanning electron microscopy (SEM). To ensure an objective analysis, SEM images were analyzed with computer vision to automatically identify nanowires and characterize each array. It is shown that FIB milling parameters can be used to control the nanowire growth. Lower ion fluence and smaller diameter holes result in a higher yield (up to 83%) of single vertical nanowires, while higher fluence and hole diameter exhibit a regime of multiple nanowires. The catalyst size distribution and placement uniformity of vertical nanowires is best for low-value parameter combinations, indicating how to improve the FIB parameters for positioned-controlled nanowire growth.

Geoscientific Characterization of the Bruce Site, Tiverton, Ontario

NASA Astrophysics Data System (ADS)

Raven, K.; Jackson, R.; Avis, J.; Clark, I.; Jensen, M.

2009-05-01

Ontario Power Generation is proposing a Deep Geologic Repository (DGR) for the long-term management of its Low and Intermediate Level Radioactive Waste (L&ILW) within a Paleozoic-age sedimentary sequence beneath the Bruce site near Tiverton, Ontario, Canada. The concept envisions that the DGR would be excavated at a depth of approximately 680 m within the Ordovician Cobourg Formation, a massive, dense, low- permeability, argillaceous limestone. Characterization of the Bruce site for waste disposal is being conducted in accordance with a four year multi-phase Geoscientific Site Characterization Plan (GSCP). The GSCP, initially developed in 2006 and later revised in 2008 to account for acquired site knowledge based on successful completion of Phase I investigations, describes the tools and methods selected for geological, hydrogeological and geomechanical site characterization. The GSCP was developed, in part, on an assessment of geoscience data needs and collection methods, review of the results of detailed geoscientific studies completed in the same bedrock formations found off the Bruce site, and recent international experience in geoscientific characterization of similar sedimentary rocks for long-term radioactive waste management purposes. Field and laboratory work related to Phase 1 and Phase 2A are nearing completion and have focused on the drilling, testing and monitoring of four continuously cored vertical boreholes through Devonian, Silurian, Ordovician and Cambrian bedrock to depths of about 860 mBGS. Work in 2009 will focus on drilling and testing of inclined boreholes to assess presence of vertical structure. The available geological, hydrogeological and hydrogeochemical data indicate the presence of remarkably uniform and predictable geology, physical hydrogeologic and geochemical properties over well separation distances exceeding 1 km. The current data set including 2-D seismic reflection surveys, field and lab hydraulic testing, lab petrophysical and diffusion testing, lab porewater and field groundwater characterization, and field head monitoring confirm the anticipated favourable characteristics of the Bruce site for long-term waste management. These favourable characteristics include a tight geomechanically stable host formation that is overlain and underlain by thick, massive, very low permeability shale and argillaceous limestone formations where radionuclide transport appears to be very limited and dominated by diffusion.

Health risk characterization of maximum legal exposures for persistent organic pollutant (POP) pesticides in residential soil: An analysis.

PubMed

Li, Zijian

2018-01-01

Regulations for pesticides in soil are important for controlling human health risk; humans can be exposed to pesticides by ingesting soil, inhaling soil dust, and through dermal contact. Previous studies focused on analyses of numerical standard values for pesticides and evaluated the same pesticide using different standards among different jurisdictions. To understand the health consequences associated with pesticide soil standard values, lifetime theoretical maximum contribution and risk characterization factors were used in this study to quantify the severity of damage using disability-adjusted life years (DALYs) under the maximum "legal" exposure to persistent organic pollutant (POP) pesticides that are commonly regulated by the Stockholm Convention. Results show that computed soil characterization factors for some pesticides present lognormal distributions, and some of them have DALY values higher than 1000.0 per million population (e.g., the DALY for dichlorodiphenyltrichloroethane [DDT] is 14,065 in the Netherlands, which exceeds the tolerable risk of uncertainty upper bound of 1380.0 DALYs). Health risk characterization factors computed from national jurisdictions illustrate that values can vary over eight orders of magnitude. Further, the computed characterization factors can vary over four orders of magnitude within the same national jurisdiction. These data indicate that there is little agreement regarding pesticide soil regulatory guidance values (RGVs) among worldwide national jurisdictions or even RGV standard values within the same jurisdiction. Among these POP pesticides, lindane has the lowest median (0.16 DALYs) and geometric mean (0.28 DALYs) risk characterization factors, indicating that worldwide national jurisdictions provide relatively conservative soil RGVs for lindane. In addition, we found that some European nations and members of the former Union of Soviet Socialist Republics share the same pesticide RGVs and data clusters for the computed characterization factors. Copyright © 2017 Elsevier Ltd. All rights reserved.

Adjustable Focus Optical Correction Lens (AFOCL)

NASA Technical Reports Server (NTRS)

Peters, Bruce R.

2001-01-01

This report describes the activities and accomplishments along with the status of the characterization of a PLZT-based Adjustable Focus Optical Correction Lens (AFOCL) test device. The activities described in this report were undertaken by members of the Center for Applied Optics (CAO) at the University of Alabama in Huntsville (UAH) under NASA Contract NAS8-00188. The effort was led by Dr. Bruce Peters as the Principal Investigator and supported by Dr. Patrick Reardon, Ms. Deborah Bailey, and graduate student Mr. Jeremy Wong. The activities outlined for the first year of the contract were to identify vendors and procure a test device along with performing the initial optical characterization of the test device. This activity has been successfully executed and test results are available and preliminary information was published at the SPIE Photonics West Conference in San Jose, January 2001. The paper, "Preliminary investigation of an active PLZT lens," was well received and generated response with several questions from the audience. A PLZT test device has been commercially procured from an outside vendor: The University of California in San Diego (UCSD) in partnership with New Interconnect Packaging Technologies (NIPT) Inc. The device has been subjected to several tests to characterize the optical performance of the device at wavelengths of interest. The goal was to evaluate the AFOCL similar to a conventional lens and measure any optical aberrations present due to the PLZT material as a deviation in the size of the diffraction limited spot (blur), the presence of diffracted energy into higher orders surrounding the focused spot (a variation in Strehl), and/or a variation or spread in the location of the focused energy away from the optical axis (a bias towards optical wedge, spherical, comma, or other higher order aberrations). While data has been collected indicative of the imaging quality of the AFOCL test device, it was not possible to fully characterize the optical performance of the AFOCL alone because there were significant optical distortions due to fabrication related issues.

Unraveling sterol-dependent membrane phenotypes by analysis of protein abundance-ratio distributions in different membrane fractions under biochemical and endogenous sterol depletion.

PubMed

Zauber, Henrik; Szymanski, Witold; Schulze, Waltraud X

2013-12-01

During the last decade, research on plasma membrane focused increasingly on the analysis of so-called microdomains. It has been shown that function of many membrane-associated proteins involved in signaling and transport depends on their conditional segregation within sterol-enriched membrane domains. High throughput proteomic analysis of sterol-protein interactions are often based on analyzing detergent resistant membrane fraction enriched in sterols and associated proteins, which also contain proteins from these microdomain structures. Most studies so far focused exclusively on the characterization of detergent resistant membrane protein composition and abundances. This approach has received some criticism because of its unspecificity and many co-purifying proteins. In this study, by a label-free quantitation approach, we extended the characterization of membrane microdomains by particularly studying distributions of each protein between detergent resistant membrane and detergent-soluble fractions (DSF). This approach allows a more stringent definition of dynamic processes between different membrane phases and provides a means of identification of co-purifying proteins. We developed a random sampling algorithm, called Unicorn, allowing for robust statistical testing of alterations in the protein distribution ratios of the two different fractions. Unicorn was validated on proteomic data from methyl-β-cyclodextrin treated plasma membranes and the sterol biosynthesis mutant smt1. Both, chemical treatment and sterol-biosynthesis mutation affected similar protein classes in their membrane phase distribution and particularly proteins with signaling and transport functions.

Unraveling Sterol-dependent Membrane Phenotypes by Analysis of Protein Abundance-ratio Distributions in Different Membrane Fractions Under Biochemical and Endogenous Sterol Depletion*

PubMed Central

Zauber, Henrik; Szymanski, Witold; Schulze, Waltraud X.

2013-01-01

During the last decade, research on plasma membrane focused increasingly on the analysis of so-called microdomains. It has been shown that function of many membrane-associated proteins involved in signaling and transport depends on their conditional segregation within sterol-enriched membrane domains. High throughput proteomic analysis of sterol-protein interactions are often based on analyzing detergent resistant membrane fraction enriched in sterols and associated proteins, which also contain proteins from these microdomain structures. Most studies so far focused exclusively on the characterization of detergent resistant membrane protein composition and abundances. This approach has received some criticism because of its unspecificity and many co-purifying proteins. In this study, by a label-free quantitation approach, we extended the characterization of membrane microdomains by particularly studying distributions of each protein between detergent resistant membrane and detergent-soluble fractions (DSF). This approach allows a more stringent definition of dynamic processes between different membrane phases and provides a means of identification of co-purifying proteins. We developed a random sampling algorithm, called Unicorn, allowing for robust statistical testing of alterations in the protein distribution ratios of the two different fractions. Unicorn was validated on proteomic data from methyl-β-cyclodextrin treated plasma membranes and the sterol biosynthesis mutant smt1. Both, chemical treatment and sterol-biosynthesis mutation affected similar protein classes in their membrane phase distribution and particularly proteins with signaling and transport functions. PMID:24030099

Synthesis and characterization of poly lactic acid and multiwall carbon nano-tubes mixtures

NASA Astrophysics Data System (ADS)

Kumar LG, Santhosh; del A. Cardona, Rocío; Berríos-Soto, Melvin; Santiago-Avilés, Jorge J.

2011-10-01

The motivation for this study is to reproduce processing conditions which lead to the formation of photo or photoinduced thermal actuation, combined with inexpensive, environmentally friendly (easily degradable) materials. Commercially available polymer, poly lactic acid (PLA), was used in our studies. PLA is a well know biodegradable polymer naturally obtained from corn. PLA was received as a solid resin in pellet form and dissolved in 1:3 acetone/chloroform solutions, to achieve the proper electrospinning kinematic viscosity. Once in the liquid phase, the material was mixed with commercially available multi-walled carbon nanotubes (MWCNTs) at varying concentrations and dispersed by severe sonication. The mixtures was electrospun at room temperature using a home built electrospinning apparatus capable of depositing randomly oriented fiber mats or oriented fibers onto different substrates, ranging from oxidized silicon wafers, alumina squares or glass microscope slides. The fibers diameters and lengths are statistically distributed following a log-normal distribution and the mean and dispersion are controlled by spinning parameters. Once the fibers were electrospun, they were compositionally, morphologically and structurally characterized by thermal and gravimetric analysis (TGA/DTA), rheology, imaging using a focused Ion Beam Scanning Electron Microscope (IBSEM), and IR /Raman methodologies. These studies can be used to explore PLA-MWCNTs mixtures suitability in applications such as super-capacitor technology, which would enable us to pursue further research in this field, while focusing on improving the electro spinning conditions so as to be able to better anticipate fiber morphology to generate a consistent regime of fibers.

A Comparison of Maternal and Paternal Experiences of Becoming Parents of a Very Preterm Infant.

PubMed

Provenzi, Livio; Barello, Serena; Fumagalli, Monica; Graffigna, Guendalina; Sirgiovanni, Ida; Savarese, Mariarosaria; Montirosso, Rosario

2016-01-01

To compare maternal and paternal experiences of very preterm (VPT) birth (gestational age < 32 weeks) and the NICU stay. Qualitative study. Data collection took place at parents' homes 3 to 6 months after NICU discharge. Ten parental couples participated in the study (20 parents). All VPT infants were healthy, without any neonatal or postnatal complications or injuries. Computer-assisted content analysis was used to highlight thematic clusters from parents' narratives, which were labeled through qualitative interpretation. Two main dimensions (Adjustment Process to Preterm Birth and Parental Role Assumption) and three main thematic clusters (Facing the Unexpected, Learning to Parent, and Finally Back Home) described the parental experience. Mothers focused mostly on the Finally Back Home cluster, which was characterized by moderate levels of adjustment to preterm birth and by awareness of their own maternal roles. Fathers focused mostly on the Learning to Parent cluster, which was characterized by low to moderate levels of adjustment to preterm birth and by a limited assumption of paternal role. To our knowledge, this study is unique in that we compared mothers and fathers who experienced the VPT births of their infants and described their experiences of the NICU stay. We found that the VPT birth experience for parents involves a dynamic adjustment. Differences in maternal and paternal experiences may indicate the need for tailored supportive interventions in the NICU. Copyright © 2016 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.

Translational progress on tumor biomarkers

PubMed Central

Guo, Hongwei; Zhou, Xiaolin; Lu, Yi; Xie, Liye; Chen, Qian; Keller, Evan T; Liu, Qian; Zhou, Qinghua; Zhang, Jian

2015-01-01

There is an urgent need to apply basic research achievements to the clinic. In particular, mechanistic studies should be developed by bench researchers, depending upon clinical demands, in order to improve the survival and quality of life of cancer patients. To date, translational medicine has been addressed in cancer biology, particularly in the identification and characterization of novel tumor biomarkers. This review focuses on the recent achievements and clinical application prospects in tumor biomarkers based on translational medicine. PMID:26557902