Science.gov

Sample records for folding carton seminar

  1. Pollution prevention assessment for a manufacturer of folding paperboard cartons

    SciTech Connect

    Edwards, H.W.; Kostrzewa, M.F.; May, M.; Looby, G.P.

    1995-08-01

    The US Environmental Protection Agency (EPA) has funded a pilot project to assist small and medium-size manufacturers who want to minimize their generation of waste but who lack the expertise to do so. In an effort to assist these manufacturers Waste Minimization Assessment Centers (WMACs) were established at selected universities and procedures were adapted from the EPA Waste Minimization Opportunity Assessment Manual. The WMAC team at Colorado State University performed an assessment at a plant that manufactures folding paperboard cartons. Paperboard stock is cut to specific sheet sizes, printed using a six-color press, cut into carton patterns, folded, and glued. The assessment team`s report detailing findings and recommendations, indicated that waste paperboard is generated in large quantities, and that the most significant cost savings can be achieved through collection and reuse of step 1 solvent used in the printing system. This Research Brief was developed by the principal investigators and EPA`s National Risk Management Research Laboratory, Cincinnati, OH, to announce key findings of an ongoing research project that is fully documented in a separate report of the same title available from University City Science Center.

  2. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  3. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE...

  4. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE...

  5. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  6. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  7. Co-composting of vegetable wastes and carton: Effect of carton composition and parameter variations.

    PubMed

    Rawoteea, Soonita Anjeena; Mudhoo, Ackmez; Kumar, Sunil

    2017-03-01

    The aim of the study was to investigate the effects of carton in the composting process of mixed vegetable wastes using an experimental composter of capacity 80L. Three different mixes were set-up (Mixes 1, 2 and 3) which consisted of vegetable wastes, 2.0kg paper and bulking agents, vegetable wastes, 1.5kg carton and bulking agents, vegetable wastes, 4.5kg carton and bulking agents, respectively. Temperature evolution, pH trends, moisture levels, respiration rates, percentage volatile solids and electrical conductivity were monitored for a period of 50days. The system remained under thermophilic conditions for a very short period due to the small size of the reactor. The three mixes did not exceed a temperature of 55°C, where sanitization takes place by the destruction of pathogens. The highest peak of CO2 evolution was observed in Mix 2 indicating that maximum microbial degradation took place in that mix.

  8. Recycling of aluminum foil from post-consumer beverage cartons

    SciTech Connect

    Charlier, P.; Sjoeberg, G.

    1995-12-31

    Recycling of aluminium contained in used aseptic beverage cartons is a difficult task which has nevertheless to be tackled by modern societies. Techniques have earlier been developed by the paper and pulp industry for the recycling of the board fibers from collected post-consumer beverage cartons. A joint technical feasibility study by Graenges and a leading beverage carton producer has dealt with different techniques for handling residues from repulsing facilities. The aluminium obtained can be used as raw material for the production of thin gauge foil, thus closing the recycling loop.

  9. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Bottle cartons, booklets and leaflets. 5.41 Section 5.41 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS...

  10. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle cartons, booklets and leaflets. 5.41 Section 5.41 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS...

  11. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Bottle cartons, booklets and leaflets. 5.41 Section 5.41 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS...

  12. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Bottle cartons, booklets and leaflets. 5.41 Section 5.41 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LABELING AND ADVERTISING OF DISTILLED SPIRITS...

  13. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Bottle cartons, booklets and leaflets. 5.41 Section 5.41 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LABELING AND ADVERTISING OF DISTILLED SPIRITS...

  14. 78 FR 24211 - Draft Guidance for Industry on Safety Considerations for Container Labels and Carton Labeling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Container Labels and Carton Labeling Design To Minimize Medication Errors; Availability AGENCY: Food and... Labels and Carton Labeling Design to Minimize Medication Errors.'' The draft guidance focuses on safety... use of the product to minimize medication errors. DATES: Although you can comment on any guidance...

  15. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... carton; (10) In the case of a product which contains an antibiotic added during the production process, the statement “Contains ___ as a preservative,” or an equivalent statement indicating the...

  16. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... carton; (10) In the case of a product which contains an antibiotic added during the production process, the statement “Contains ___ as a preservative,” or an equivalent statement indicating the...

  17. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... carton; (10) In the case of a product which contains an antibiotic added during the production process, the statement “Contains ___ as a preservative,” or an equivalent statement indicating the...

  18. Determination of activation energy of pyrolysis of carton packaging wastes and its pure components using thermogravimetry.

    PubMed

    Alvarenga, Larissa M; Xavier, Thiago P; Barrozo, Marcos Antonio S; Bacelos, Marcelo S; Lira, Taisa S

    2016-07-01

    Many processes have been used for recycling of carton packaging wastes. The pyrolysis highlights as a promising technology to be used for recovering the aluminum from polyethylene and generating products with high heating value. In this paper, a study on pyrolysis reactions of carton packaging wastes and its pure components was performed in order to estimate the kinetic parameters of these reactions. For this, dynamic thermogravimetric analyses were carried out and two different kinds of kinetic models were used: the isoconversional and Independent Parallel Reactions. Isoconversional models allowed to calculate the overall activation energy of the pyrolysis reaction, in according to their conversions. The IPR model, in turn, allowed the calculation of kinetic parameters of each one of the carton packaging and paperboard subcomponents. The carton packaging pyrolysis follows three separated stages of devolatilization. The first step is moisture loss. The second stage is perfectly correlated to devolatilization of cardboard. The third step is correlated to devolatilization of polyethylene.

  19. Nutrient Control Seminars

    EPA Science Inventory

    These Nutrient Control Seminars will present an extensive state-of-the-technology review of the engineering design and operation of nitrogen and phosphorous control technologies and techniques applied at municipal wastewater treatment plants (WWTPs). These seminars will present ...

  20. Mycelial carton galleries of Azteca brevis (Formicidae) as a multi-species network.

    PubMed

    Mayer, Veronika E; Voglmayr, Hermann

    2009-09-22

    Apart from growing fungi for nutrition, as seen in the New World Attini, ants cultivate fungi for reinforcement of the walls of their nests or tunnel-shaped runway galleries. These fungi are grown on organic material such as bark, epiphylls or trichomes, and form stable 'carton structures'. In this study, the carton of the runway galleries built by Azteca brevis (Formicidae, Dolichoderinae) on branches of Tetrathylacium macrophyllum (Flacourtiaceae) is investigated. For the first time, molecular tools are used to address the biodiversity and phylogenetic affinities of fungi involved in tropical ant carton architecture, a previously neglected ant-fungus mutualism. The A. brevis carton involves a complex association of several fungi. All the isolated fungi were unequivocally placed within the Chaetothyriales by DNA sequence data. Whereas five types of fungal hyphae were morphologically distinguishable, our DNA data showed that more species are involved, applying a phylogenetic species concept based on DNA phylogenies and hyphal morphology. In contrast to the New World Attini with their many-to-one (different ant species-one fungal cultivar) pattern, and temperate Lasius with a one-to-two (one ant species-two mutualists) or many-to-one (different ant species share the same mutualist) system, the A. brevis-fungi association is a one-to-many multi-species network. Vertical fungus transmission has not yet been found, indicating that the A. brevis-fungi interaction is rather generalized.

  1. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., and enclosure. 112.2 Section 112.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS... carton; (10) In the case of a product which contains an antibiotic added during the production...

  2. Mycelial carton galleries of Azteca brevis (Formicidae) as a multi-species network

    PubMed Central

    Mayer, Veronika E.; Voglmayr, Hermann

    2009-01-01

    Apart from growing fungi for nutrition, as seen in the New World Attini, ants cultivate fungi for reinforcement of the walls of their nests or tunnel-shaped runway galleries. These fungi are grown on organic material such as bark, epiphylls or trichomes, and form stable ‘carton structures’. In this study, the carton of the runway galleries built by Azteca brevis (Formicidae, Dolichoderinae) on branches of Tetrathylacium macrophyllum (Flacourtiaceae) is investigated. For the first time, molecular tools are used to address the biodiversity and phylogenetic affinities of fungi involved in tropical ant carton architecture, a previously neglected ant–fungus mutualism. The A. brevis carton involves a complex association of several fungi. All the isolated fungi were unequivocally placed within the Chaetothyriales by DNA sequence data. Whereas five types of fungal hyphae were morphologically distinguishable, our DNA data showed that more species are involved, applying a phylogenetic species concept based on DNA phylogenies and hyphal morphology. In contrast to the New World Attini with their many-to-one (different ant species—one fungal cultivar) pattern, and temperate Lasius with a one-to-two (one ant species—two mutualists) or many-to-one (different ant species share the same mutualist) system, the A. brevis–fungi association is a one-to-many multi-species network. Vertical fungus transmission has not yet been found, indicating that the A. brevis–fungi interaction is rather generalized. PMID:19556257

  3. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Bottle cartons, booklets and leaflets. 4.38a Section 4.38a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LABELING AND ADVERTISING OF WINE Labeling...

  4. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Bottle cartons, booklets and leaflets. 4.38a Section 4.38a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Labeling...

  5. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle cartons, booklets and leaflets. 4.38a Section 4.38a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Labeling...

  6. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Bottle cartons, booklets and leaflets. 4.38a Section 4.38a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LABELING AND ADVERTISING OF WINE Labeling...

  7. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Bottle cartons, booklets and leaflets. 4.38a Section 4.38a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Labeling...

  8. NCEER seminars on earthquakes

    USGS Publications Warehouse

    Pantelic, J.

    1987-01-01

    In May of 1986, the National Center for Earthquake Engineering Research (NCEER) in Buffalo, New York, held the first seminar in its new monthly forum called Seminars on Earthquakes. The Center's purpose in initiating the seminars was to educate the audience about earthquakes, to facilitate cooperation between the NCEER and visiting researchers, and to enable visiting speakers to learn more about the NCEER   

  9. AMAS Robotics Seminar Brief

    DTIC Science & Technology

    2011-07-19

    Unclassified Unclassified 19 July 2011 AMAS ROBOTICS SEMINAR BRIEF Aaron Hart, Product Integrator, RS JPO DISTRIBUTION STATEMENT A. Approved for...19-07-2011 to 19-07-2011 4. TITLE AND SUBTITLE robotics seminar brief 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES AMAS ROBOTICS SEMINAR BRIEF 14

  10. Technical Seminar: "Crash Safety"""

    NASA Video Gallery

    This seminar addresses the history and successful progress in predicting and improving the crash safety characteristics of vehicles, with particular emphasis on rotary wing aircraft and composite s...

  11. Astronomy Research Seminar

    NASA Astrophysics Data System (ADS)

    Johson, Jolyon; Genet, Russell; Armstrong, James; Boyce, Grady; Boyce, Pat; Brewer, Mark; Buchheim, Robert; Carro, Joseph; Estrada, Reed; Estrada, Chris; Freed, Rachel; Gillette, Sean; Harshaw, Richard; Hollis, Thomas; Kenney, John; McGaughey, Seven; McNab, Christine; Mohanan, Kakkala; Sepulveda, Babs; Wallace, Dan; Wallen, Vera

    2015-05-01

    Traditional science lectures and labs are often enhanced through project- and team-based learning. Some students go beyond these classroom studies by conducting research, often under the guidance of university professors. A one-semester astronomy research seminar was initiated in 2006 in collaboration with the community of professional and amateur double star astronomers. The result was dozens of jointly-authored papers published in the Journal of Double Star Observations and the Annual Proceedings of the Society of Astronomical Sciences. This seminar, and its affiliated community, launched a series of conferences and books, providing students with additional forums to share their double star research. The original seminar, and its derivatives, enhanced educational careers through college admissions and scholarships. To expand the seminar's reach, it was restructured from a few teams at one school, to many teams, each from a different school. A volunteer from each school became an assistant instructor. Most of them were seminar veterans, experienced astronomers, or science teachers. The assistant instructors, in turn, recruited enthusiastic students for their teams. To avoid student and instructor overload, the seminar focused on its three deliverables: a formal proposal, published paper, and public PowerPoint presentation. Future seminars may offer other astronomical research options such as exoplanet transit or eclipsing binary photometry.

  12. Anthocyanin degradation of blueberry-aronia nectar in glass compared with carton during storage.

    PubMed

    Trost, K; Golc-Wondra, A; Prosek, M; Milivojevic, L

    2008-10-01

    Blueberry-aronia nectar is known as a rich source of anthocyanins, which are mostly destroyed during commercial storage of the product. The factors influencing the rate of degradation are connected to the oxygen protection offered by the packaging, as well as the type of anthocyanidin and the amount of glycosylated sugar. The current study was aimed to compare the stability of total anthocyanin between glass and carton packaging as well as to determine the stability of individual anthocyanin with respect to aglycone and glycosylated sugar. The degradation rate of total anthocyanin degradation rate was 22% higher in carton packaging than glass bottle. The ranking order of the stability of individual anthocyanin with respect to aglycone was as follows (from the most to least stable): cyanindin > peonidin > petunidin > malvidin = delphinidin. The ranking order of the stability of anthocyanins with respect to glycosylated sugars was as follows (from the most to least stable): glucose > galactose > arabinose. As individual anthocyanins have different degradation rates this study can be used to determine the most stable natural colorant and the most sensitive antioxidant among the anthocyanins tested.

  13. Folding Beauties

    ERIC Educational Resources Information Center

    Berman, Leah Wrenn

    2006-01-01

    This article has its genesis in an MAA mini-course on origami, where a way to get a parabola by folding paper was presented. This article discusses the methods and mathematics of other curves obtained by paper-folding.

  14. Technical assessment of processing plants as exemplified by the sorting of beverage cartons from lightweight packaging wastes.

    PubMed

    Feil, A; Thoden van Velzen, E U; Jansen, M; Vitz, P; Go, N; Pretz, T

    2016-02-01

    The recovery of beverage cartons (BC) in three lightweight packaging waste processing plants (LP) was analyzed with different input materials and input masses in the area of 21-50Mg. The data was generated by gravimetric determination of the sorting products, sampling and sorting analysis. Since the particle size of beverage cartons is larger than 120mm, a modified sampling plan was implemented and targeted multiple sampling (3-11 individual samplings) and a total sample size of respectively 1200l (ca. 60kg) for the BC-products and of about 2400l (ca. 120kg) for material-heterogeneous mixed plastics (MP) and sorting residue products. The results infer that the quantification of the beverage carton yield in the process, i.e., by including all product-containing material streams, can be specified only with considerable fluctuation ranges. Consequently, the total assessment, regarding all product streams, is rather qualitative than quantitative. Irregular operation conditions as well as unfavorable sampling conditions and capacity overloads are likely causes for high confidence intervals. From the results of the current study, recommendations can basically be derived for a better sampling in LP-processing plants. Despite of the suboptimal statistical results, the results indicate very clear that the plants show definite optimisation potentials with regard to the yield of beverage cartons as well as the required product purity. Due to the test character of the sorting trials the plant parameterization was not ideal for this sorting task and consequently the results should be interpreted with care.

  15. Extreme Folding

    NASA Astrophysics Data System (ADS)

    Demaine, Erik

    2012-02-01

    Our understanding of the mathematics and algorithms behind paper folding, and geometric folding in general, has increased dramatically over the past several years. These developments have found a surprisingly broad range of applications. In the art of origami, it has helped spur the technical origami revolution. In engineering and science, it has helped solve problems in areas such as manufacturing, robotics, graphics, and protein folding. On the recreational side, it has led to new kinds of folding puzzles and magic. I will give an overview of the mathematics and algorithms of folding, with a focus on new mathematics and sculpture.

  16. Fuel cells seminar

    SciTech Connect

    1996-12-01

    This year`s meeting highlights the fact that fuel cells for both stationary and transportation applications have reached the dawn of commercialization. Sales of stationary fuel cells have grown steadily over the past 2 years. Phosphoric acid fuel cell buses have been demonstrated in urban areas. Proton-exchange membrane fuel cells are on the verge of revolutionizing the transportation industry. These activities and many more are discussed during this seminar, which provides a forum for people from the international fuel cell community engaged in a wide spectrum of fuel cell activities. Discussions addressing R&D of fuel cell technologies, manufacturing and marketing of fuel cells, and experiences of fuel cell users took place through oral and poster presentations. For the first time, the seminar included commercial exhibits, further evidence that commercial fuel cell technology has arrived. A total of 205 papers is included in this volume.

  17. Interdisciplinary Distinguished Seminar Series

    DTIC Science & Technology

    2014-08-29

    information sciences , nanotechnology, mathematics, and physics. The list of speakers included leaders of the respective fields from the US and abroad...and engineering, computer science and mathematics. The list of speakers included leaders of the respective fields from the US and abroad. All the...summary, this funded Interdisciplinary Seminar Series have not only brought the best in the disciplines of Information Science and Systems, but as an

  18. A Seminar for Minority Students.

    ERIC Educational Resources Information Center

    Malhiot, Grete; Ninan, Mary

    1979-01-01

    Describes a seminar for minority, particularly Black, students entering the junior year at the School of Nursing, Loyola University of Chicago. Seminar objective was to give academic, emotional, and social support. Notes changing minority student attitudes, the need for earlier tutoring for academic weakness, and the value of group discussion. (MF)

  19. The Efficacy of Seminar Courses

    ERIC Educational Resources Information Center

    Tsui, Lisa; Gao, Eleanor

    2007-01-01

    This study explores the relationship between the seminar course model and critical thinking development among students through qualitative data collected from four strategically chosen case study institutions. Results of a cross-case analysis suggest that the seminar approach provides fertile ground for the cultivation of critical thinking skills…

  20. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars for employees of retailers either at the industry member's... equipment, training seminars for employees of retailers, or tours of industry member's plant premises....

  1. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Educational seminars. 6.94... OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars for employees of retailers either at the industry...

  2. BAAL/CUP Seminars 2009

    ERIC Educational Resources Information Center

    Cutting, Joan; Murphy, Brona

    2010-01-01

    The seminar, organised by Joan Cutting and Brona Murphy, aimed: (1) to bring together researchers involved in both emergent and established academic corpora (written and spoken) as well as linguists, lecturers and teachers researching in education, be it language teaching, language-teacher training or continuing professional development in…

  3. Music, Art, Drama, Civilization Seminar.

    ERIC Educational Resources Information Center

    Hampton City School Board, VA.

    This 1-year elective seminar for high school students is to be taught in five units--Introduction, the Ancient World, the Medieval World, the Renaissance, and the Modern World--with emphasis on four basic themes expressed creatively throughout western history: (1) the common man, (2) the individual, (3) religion, and (4) conflict. Instruction on a…

  4. Seminar on Usher's Syndrome: Proceedings.

    ERIC Educational Resources Information Center

    Rochester School for the Deaf, NY.

    Summarized are the presentation of M. Vernon and the Comments of primary panelists from a seminar on Usher's Syndrome, a genetic disease involving congenital deafness and progressive loss of vision due to retinitis pigmentosa. The following topics are addressed: genetics today, nature of Usher's Syndrome, symptoms, prevalence, lay diagnosis for…

  5. Geosynchronous Meteorological Satellite Data Seminar

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A seminar was organized by NASA to acquaint the meteorological community with data now available, and data scheduled to be available in the future, from geosynchronous meteorological satellites. The twenty-four papers were presented in three half-day sessions in addition to tours of the Image Display and LANDSAT Processing Facilities during the afternoon of the second day.

  6. European Seminar on Neural Computing

    DTIC Science & Technology

    1988-08-31

    weights) There are three distinct approaches currently being of the connections between PE’s, analogous to synaptic taken for supporting neural ...for creation of dedicated re- * Connectionist models for artificial intelligence (Al) search centers, analogous to the Computer and Neural System...IONDOIL ONRL Report 8 Oo Ln 0In t m S D TIC European Seminar on Neural Computing 1 IELECTE is MAY 161990 L D % Claire Zomzely-Neurath 31 August 1988

  7. Proceedings of the Alternate Energy Systems Seminar

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The Alternative Energy Systems Seminar was held on March 30, 1978, and was sponsored jointly be the Southwest District Office of the U.S. Department of Energy and JPL. The seminar was an experiment in information exchange with the aim of presenting, in a single day, status and prospects for a number of advanced energy systems to a diverse, largely nontechnical audience, and to solicit post-seminar responses from that audience as to the seminar's usefulness. The major systems presented are: (1) Solar Photovoltaic; (2) Geothermal; (3) Cogeneration Power; (4) Solar Thermal; (5) Solar Heating and Cooling; (6) Wind Energy; and (7) Systems Considerations.

  8. VOLATILE ORGANIC COMPOUNDS (VOC) RECOVERY SEMINAR

    EPA Science Inventory

    The purpose of the seminar was to bring researchers, technology developers, and industry representatives together to discuss recovery technologies and techniques for VOCs. The seminar focused on the specific VOC recovery needs of industry and on case studies that summarize effec...

  9. International Seminar on Publications in Continuing Education.

    ERIC Educational Resources Information Center

    Charters, Alexander N., Ed.; Rivera, William M., Ed.

    Substantive papers presented at the third in a series of international seminars sponsored by Syracuse University are provided in this publication. In addition, a summary of the themes, or issues, as they emerged in the discussion is given. The seminar focused on publications in the professional field of adult education. The papers presented are as…

  10. Designing a Graduate Seminar in Academic Writing.

    ERIC Educational Resources Information Center

    Gaillet, Lynee Lewis

    An English 812 class in expository writing at Georgia State University was restructured by the instructor to become a seminar in academic publishing. Often, lengthy assignments are assigned in graduate seminar courses, with professors incorrectly assuming that graduate students already have knowledge of the writing process, when they often do not.…

  11. Literature Seminars for Gifted and Talented Students.

    ERIC Educational Resources Information Center

    Dixon, Felicia A.

    1993-01-01

    The literature seminar format meets the needs of gifted students for intellectual challenges, complex curricular experiences, creative research and writing activities, and stimulating interactions. Three seminars conducted in the English curriculum at a special school for gifted students are described: "Dickens and the Industrial…

  12. Induction Seminars as Professional Learning Communities for Beginning Teachers

    ERIC Educational Resources Information Center

    Fresko, Barbara; Nasser-Abu Alhija, Fadia

    2015-01-01

    This paper explores the operation and contribution of induction seminars operated as learning communities for new teachers. Mixed methods were used: 378 new teachers and 29 seminar leaders completed questionnaires, 16 new teachers and 14 seminar leaders were interviewed, and 20 seminar meetings were observed. Findings showed that seminar…

  13. Senior Seminar: Across a Department and across The Years

    ERIC Educational Resources Information Center

    Greer, Meredith L.; Ross, Chip

    2013-01-01

    The Department of Mathematics at Bates College has offered a senior seminar capstone course for over a dozen years. In this article, we discuss the coexistence of seminar and thesis, our other capstone experience. We discuss in detail the goals of our seminar, various ways we structure the seminar to accomplish those goals, and methods of…

  14. Increasing Effectiveness of Strategic Planning Seminars through Learning Style

    ERIC Educational Resources Information Center

    Yildirim, Nail

    2010-01-01

    This research tests the effectiveness of taking learning style variables from the Kolb learning model in designing strategic planning seminars. We observe in our research that the participants in the seminar--school principals--positively judge the effectiveness of the seminar. The research also tests the seminar's effectiveness in terms of the…

  15. The effective supervision seminar the management development seminar

    SciTech Connect

    Not Available

    1989-09-01

    The Department of Energy (DOE) has been providing the Effective Supervision Seminar (ESS) on a regular basis since 1978. The course is primarily targeted for new, probationary DOE supervisors. Incumbent supervisors who have not had equivalent training or haven't had supervisory training for the past five years are also eligible to participate in ESS as are non-supervisory employees whose need for the training can be justified under special circumstances. The ESS program fulfills 40 hours of the 80 hours of supervisory training that is required for DOE supervisors. The course is intended to enable the participants to understand supervisory methods and techniques and to apply interpersonal skills and supervisory principles in carrying out their duties as DOE supervisors. The mandatory nature of the ESS program, when coupled with the extremely broad diversity of technical and professional occupational fields that are represented in DOE headquarters and field operations, makes the achievement of these objectives particularly challenging and rewarding.

  16. High Diversity and Low Specificity of Chaetothyrialean Fungi in Carton Galleries in a Neotropical Ant–Plant Association

    PubMed Central

    Nepel, Maximilian; Voglmayr, Hermann; Schönenberger, Jürg; Mayer, Veronika E.

    2014-01-01

    New associations have recently been discovered between arboreal ants that live on myrmecophytic plants, and different groups of fungi. Most of the – usually undescribed – fungi cultured by the ants belong to the order Chaetothyriales (Ascomycetes). Chaetothyriales occur in the nesting spaces provided by the host plant, and form a major part of the cardboard-like material produced by the ants for constructing nests and runway galleries. Until now, the fungi have been considered specific to each ant species. We focus on the three-way association between the plant Tetrathylacium macrophyllum (Salicaceae), the ant Azteca brevis (Formicidae: Dolichoderinae) and various chaetothyrialean fungi. Azteca brevis builds extensive runway galleries along branches of T. macrophyllum. The carton of the gallery walls consists of masticated plant material densely pervaded by chaetothyrialean hyphae. In order to characterise the specificity of the ant–fungus association, fungi from the runway galleries of 19 ant colonies were grown as pure cultures and analyzed using partial SSU, complete ITS, 5.8S and partial LSU rDNA sequences. This gave 128 different fungal genotypes, 78% of which were clustered into three monophyletic groups. The most common fungus (either genotype or approximate species-level OTU) was found in the runway galleries of 63% of the investigated ant colonies. This indicates that there can be a dominant fungus but, in general, a wider guild of chaetothyrialean fungi share the same ant mutualist in Azteca brevis. PMID:25398091

  17. Public Relations Guide. Featuring PR Tools, PR Techniques, How To Set Up a PR Seminar. Revised Edition.

    ERIC Educational Resources Information Center

    Procter and Gamble Educational Services, Cincinnati, OH.

    The goal of this guide is two-fold: (1) to equip readers with practical guidelines for establishing communications plans and making those plans work; and (2) to develop information for implementing a public relations seminar targeted at designing workshops that reach a broad segment of members. Five topics are addressed: (1) the basic public…

  18. Hilbert at Vassar: An Undergraduate Seminar.

    ERIC Educational Resources Information Center

    Feroe, John A.

    1978-01-01

    A description is given of a senior seminar in which each student reported on a topic centered around the works of David Hilbert. A brief description of each topic is given as well as a list of references. (MP)

  19. SEMINAR PROCEEDINGS: RCRA CORRECTIVE ACTION STABILIZATION TECHNOLOGIES

    EPA Science Inventory

    The seminar publication provides an overview of many technologies that can be used in applying the stabilization concept to RCRA cleanup activities. Technologies discussed include covers, grouting, slurry walls, hydrofracture, horizontal well drilling, a vacuum extraction, and b...

  20. Technical Seminar: "Trajectory-Based Operations"""

    NASA Video Gallery

    A safe and efficient air traffic management system is vital to the nation's economy. This seminar explores the concepts and current research into air traffic control concepts that focus on more dim...

  1. Provocative Questions in Cancer: NCI Seminar

    Cancer.gov

    science writers' seminar to discuss various aspects of one of NCI’s signature efforts -- the Provocative Questions project. Discussion will focus on the scientific research that surrounds some of these questions.

  2. NASA Seminar on Organization and Management

    NASA Technical Reports Server (NTRS)

    Crawley, R. W.; Kloman, E. H.

    1972-01-01

    The proceedings of a seminar series of current problems and organization of NASA are presented. The seminar was designed to provide a comparative basis for understanding such recurring problems as delegation of authority, resource allocation and decision making patterns, headquarters organization, systems of program control and evaluation, roles and relations of scientists, engineers, and administrators, headquarters-field center relationships, and the overall management philosophy of the headquarters and field centers.

  3. 2015 Cross-Domain Deterrence Seminar Bibliography

    SciTech Connect

    Juarez, Anthony

    2016-02-04

    In November 2015, the Center for Global Security Research, NSO, and Global Security program jointly sponsored a seminar investigating questions related to cross-domain deterrence at Lawrence Livermore National Laboratory. At the seminar, experts were asked to moderate discussion based on the four topics below. For each of these topics, we have compiled a short list of literature that will help analysts develop a baseline understanding of the issue.

  4. United States Savings Bonds Seminar: Seminar Leader's Guide. 3rd Edition.

    ERIC Educational Resources Information Center

    Department of the Treasury, Washington, DC.

    This leader's guide is designed for use in conducting a seminar to train bank employees in correct procedures for issuing and redeeming U.S. Savings Bonds and in answering routine customer inquiries concerning savings bonds. Included in the first section of the guide are an overview of the purpose and content of the seminar, procedures for…

  5. Mechanics of Curved Folds

    NASA Astrophysics Data System (ADS)

    Dias, Marcelo A.; Santangelo, Christian D.

    2011-03-01

    Despite an almost two thousand year history, origami, the art of folding paper, remains a challenge both artistically and scientifically. Traditionally, origami is practiced by folding along straight creases. A whole new set of shapes can be explored, however, if, instead of straight creases, one folds along arbitrary curves. We present a mechanical model for curved fold origami in which the energy of a plastically-deformed crease is balanced by the bending energy of developable regions on either side of the crease. Though geometry requires that a sheet buckle when folded along a closed curve, its shape depends on the elasticity of the sheet. NSF DMR-0846582.

  6. Freshman Seminars: Interdisciplinary Engagements in Astronomy

    NASA Astrophysics Data System (ADS)

    Hemenway, M. K.

    2006-08-01

    The Freshman Seminar program at the University of Texas is designed to allow groups of fifteen students an engaging introduction to the University. The seminars introduce students to the resources of the university and allow them to identify interesting subjects for further research or future careers. An emphasis on oral and written communication by the students provides these first-year students a transition to college-level writing and thinking. Seminar activities include field trips to an art museum, a research library, and the Humanities Research Center rare book collection. This paper will report on two seminars, each fifteen weeks in length. In "The Galileo Scandal" students examine Galileo's struggle with the church (including a mock trial). They perform activities that connect his use of the telescope and observations to astronomical concepts. In "Astronomy and the Humanities" students analyze various forms of human expression that have astronomical connections (art, drama, literature, music, poetry, and science fiction); they perform hands-on activities to reinforce the related astronomy concepts. Evaluation of the seminars indicates student engagement and improvement in communication skills. Many of the activities could be used independently to engage students enrolled in standard introductory astronomy classes.

  7. Origin of Permian andesites from Xi Ujimqin, the Hinggan Mountains: Contributions of lower crust North China Carton

    NASA Astrophysics Data System (ADS)

    Gao, X.

    2014-12-01

    Andesite magmas at convergent margins are enriched in silica compared to magmas erupting at mid-ocean ridges and intra-plate volcanoes. Determining the cause (s) of silica enrichment is fundamental for models of continental crust formation, arc growth rates and across-arc mass balances (Plank and Langmuir, 1993; Rudnick, 1995; White et al., 2006).The Xi-Ujimqin is located the eastern segment of the Central Asian Orogenic Belt , the CAOB is composed of mainly subduction-accretion complexes, intruded by vast plutons of mainly magmatic arc origin and covered in places by their volcanic derivatives (Sengor et al. 1993; Sengor and Natalin 1996). As the most important site for Phanerozoic crustal growth in the world, the subduction-accretion complexes added ~ 5.3 million km2of material to Asia, half of which may be of juvenile origin (Sengor et al. 1993).The andesitic lavas of Daotenuoer Fms. at Xi-Ujimqin have different trace and Sr-Nd-Pb isotopic characteristic from them, these rocks span a SiO2 range of 56.83 ~ 59.17% and MgO of range of 1.21~2.91%, characterized by obviously LREE/HREE fractionation (Ce/YbCN = 11.6 ~ 16.8), strong LILE enrichment and variable Nb-Ta and Sr depletion. They have more radiogenic Sr and less radiogenic Nd and Pb isotopic composition (87Sr/86Sr(i) = 0.7063 ~ 0.7066, eNd(t) = -10.5 ~ -6.3,TDM = 1.22 ~ 1.51Ga, 206Pb / 204Pb(i) = 17.29 ~ 17.33, D7/4 = 3.7 ~ 6.9, D 8/4 = 94 ~ 104) than the contemporaneous intermediate-felsic volcanic lavas. Zircon U-Pb dating results give an emplacement age of ~253 Ma for the these rocks by LA-ICP-MS, corresponding to the Late Permian. The features of major, trace and Sr-Nd-Pb isotope of These rocks imply its sources are of attributes of lower crust North China Carton (NCC) during Paleozoic subduction and collision related to the closure of the Chinese segment of the Paleo-Asian Ocean between the NCC and south Mongolia Block (Sengor et al., 1993).

  8. Elbow Synovial Fold Syndrome

    DTIC Science & Technology

    2007-12-01

    Density MR with arrows The clinical differential diagnosis of plica syndrome includes lateral epicondylitis (aka tennis elbow ), loose bodies... Elbow Synovial Fold Syndrome Radiology Corner Elbow Synovial Fold Syndrome Guarantor: CPT Amit Sanghi, USA, MC FS Contributors: CPT Amit...the case of a 17 year old female with elbow synovial fold syndrome (aka plica synovialis). The etiology is thought to be related to repetitive

  9. Whither Thou Goest: The Intrigue of an International Study Seminar.

    ERIC Educational Resources Information Center

    Patten, Ronald J.; Peters, Robert

    This paper describes one business school's response to the challenges of globalization. After faculty members taught seminars in other countries, an interest was expressed in conducting international study seminars for the school's business students. One-week seminars were arranged, which allowed part-time, employed MBA students to enroll. The…

  10. POS 591: International Relations Seminar "The Modern World-System."

    ERIC Educational Resources Information Center

    McGowan, Patrick J.

    The syllabus outlines a college level international relations seminar with a neo-Marxist theoretical orientation. The objective of the seminar is to present an historical and comparative approach to a study of the evolution of the international political economy. Following an introduction explaining seminar objectives, grading, and course…

  11. Should We Bother Improving Students' Attendance at Seminars?

    ERIC Educational Resources Information Center

    Gbadamosi, Gbolahan

    2015-01-01

    This study uses action research intervention to improve students' attendance at seminars. Specifically, the study asks the question: will students' attendance improve if they drive their own learning by running their own seminars? Records of lecture and seminar attendance at a module and comparative ones were used. Focus group interviews provided…

  12. Fulbright-Hays Seminars Abroad Program and Special Bilateral Projects

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The Fulbright-Hays Seminars Abroad Program and Special Bilateral Projects provides short-term study and travel seminars abroad for U.S. educators in the social sciences and humanities for the purpose of improving their understanding and knowledge of the people and culture of other countries. There are approximately 10 seminars with 16 participants…

  13. Improving Cognitive Complexity via Seminar Methodology in Higher Education

    ERIC Educational Resources Information Center

    Lopez, Pau; Gallifa, Josep

    2008-01-01

    This paper presents the main functions that university plays in society and describes the seminar methodology created at Ramon Llull University. Specifically the article focuses on and explains how seminars help to promote complex knowledge in students. An empirical study with students participating in seminars is designed to assess the…

  14. Seminar for Master's Thesis Projects: Promoting Students' Self-Regulation

    ERIC Educational Resources Information Center

    Miedijensky, Shirley; Lichtinger, Einat

    2016-01-01

    This study presents a thesis seminar model aimed at promoting students' self-regulation. Students' perceptions regarding the contribution of the seminar to their learning process were characterized and the seminar's effect upon their self-regulation expressions was examined. Data was collected using questionnaires and analyzed thematically. The…

  15. Reviving Graduate Seminar Series through Non-Technical Presentations

    ERIC Educational Resources Information Center

    Madihally, Sundararajan V.

    2011-01-01

    Most chemical engineering programs that offer M.S. and Ph.D. degrees have a common seminar series for all the graduate students. Many would agree that seminars lack student interest, leading to ineffectiveness. We questioned the possibility of adding value to the seminar series by incorporating non-technical topics that may be more important to…

  16. Fast protein folding kinetics

    PubMed Central

    Gelman, Hannah; Gruebele, Martin

    2014-01-01

    Fast folding proteins have been a major focus of computational and experimental study because they are accessible to both techniques: they are small and fast enough to be reasonably simulated with current computational power, but have dynamics slow enough to be observed with specially developed experimental techniques. This coupled study of fast folding proteins has provided insight into the mechanisms which allow some proteins to find their native conformation well less than 1 ms and has uncovered examples of theoretically predicted phenomena such as downhill folding. The study of fast folders also informs our understanding of even “slow” folding processes: fast folders are small, relatively simple protein domains and the principles that govern their folding also govern the folding of more complex systems. This review summarizes the major theoretical and experimental techniques used to study fast folding proteins and provides an overview of the major findings of fast folding research. Finally, we examine the themes that have emerged from studying fast folders and briefly summarize their application to protein folding in general as well as some work that is left to do. PMID:24641816

  17. A galaxy of folds

    PubMed Central

    Alva, Vikram; Remmert, Michael; Biegert, Andreas; Lupas, Andrei N; Söding, Johannes

    2010-01-01

    Many protein classification systems capture homologous relationships by grouping domains into families and superfamilies on the basis of sequence similarity. Superfamilies with similar 3D structures are further grouped into folds. In the absence of discernable sequence similarity, these structural similarities were long thought to have originated independently, by convergent evolution. However, the growth of databases and advances in sequence comparison methods have led to the discovery of many distant evolutionary relationships that transcend the boundaries of superfamilies and folds. To investigate the contributions of convergent versus divergent evolution in the origin of protein folds, we clustered representative domains of known structure by their sequence similarity, treating them as point masses in a virtual 2D space which attract or repel each other depending on their pairwise sequence similarities. As expected, families in the same superfamily form tight clusters. But often, superfamilies of the same fold are linked with each other, suggesting that the entire fold evolved from an ancient prototype. Strikingly, some links connect superfamilies with different folds. They arise from modular peptide fragments of between 20 and 40 residues that co-occur in the connected folds in disparate structural contexts. These may be descendants of an ancestral pool of peptide modules that evolved as cofactors in the RNA world and from which the first folded proteins arose by amplification and recombination. Our galaxy of folds summarizes, in a single image, most known and many yet undescribed homologous relationships between protein superfamilies, providing new insights into the evolution of protein domains. PMID:19937658

  18. A galaxy of folds.

    PubMed

    Alva, Vikram; Remmert, Michael; Biegert, Andreas; Lupas, Andrei N; Söding, Johannes

    2010-01-01

    Many protein classification systems capture homologous relationships by grouping domains into families and superfamilies on the basis of sequence similarity. Superfamilies with similar 3D structures are further grouped into folds. In the absence of discernable sequence similarity, these structural similarities were long thought to have originated independently, by convergent evolution. However, the growth of databases and advances in sequence comparison methods have led to the discovery of many distant evolutionary relationships that transcend the boundaries of superfamilies and folds. To investigate the contributions of convergent versus divergent evolution in the origin of protein folds, we clustered representative domains of known structure by their sequence similarity, treating them as point masses in a virtual 2D space which attract or repel each other depending on their pairwise sequence similarities. As expected, families in the same superfamily form tight clusters. But often, superfamilies of the same fold are linked with each other, suggesting that the entire fold evolved from an ancient prototype. Strikingly, some links connect superfamilies with different folds. They arise from modular peptide fragments of between 20 and 40 residues that co-occur in the connected folds in disparate structural contexts. These may be descendants of an ancestral pool of peptide modules that evolved as cofactors in the RNA world and from which the first folded proteins arose by amplification and recombination. Our galaxy of folds summarizes, in a single image, most known and many yet undescribed homologous relationships between protein superfamilies, providing new insights into the evolution of protein domains.

  19. Proceedings: EPRI Second Phased Array Inspection Seminar

    SciTech Connect

    2001-11-01

    The Second EPRI Phased Array Inspection Seminar focused on industrial applications of phased array technology that have been achieved to date or are planned for the near future. Presentations were made by developers of inspection techniques, inspection services vendors, and utility personnel who have performed inspections using arrays.

  20. Undergraduate Seminars: The Poster Session Solution.

    ERIC Educational Resources Information Center

    Chute, Douglas L.; Bank, Barry

    1983-01-01

    A good alternative to the undergraduate psychology seminar is the poster session. During the course each student wrote a review paper. For use in his/her class presentation, the student provided the following information on poster paper: title, author, abstract, a few graphs or illustrations from the literature, conclusions, and references. (RM)

  1. The American Indian: A Freshman Investigative Seminar.

    ERIC Educational Resources Information Center

    Fullman, Christopher E.

    As a recent curriculum innovation replacing Freshman English, the Freshman Investigative Seminar consists of 12 or 13 students meeting for one semester of five weekly class hours, directed by faculty from different disciplines. Its objectives are to lead the student to learn how to gather information from various sources, how to keep accurate…

  2. Cultural Decentralization. Report of a Seminar.

    ERIC Educational Resources Information Center

    Findlater, Richard

    This document describes the results of a seminar convened in England and attended by representatives of national, regional, state, and local cultural organizations from France, the Netherlands, Sweden, the United Kingdom, and the United States. An overview of the status of decentralization in cultural programming opens the document. Diverging…

  3. The Slavonic Studies Seminar in Bulgaria.

    ERIC Educational Resources Information Center

    Winokur, Marshall

    The Slavonic Studies Seminar is held for one month each summer at Kliment Okhridski University in Sofia, Bulgaria. The program consists of three weeks of Bulgarian language instruction and a one-week trip around Bulgaria through interesting medieval towns, monasteries, and coastal resorts. The participants are primarily college teachers,…

  4. Seminars on Occupational Clusters. A Report.

    ERIC Educational Resources Information Center

    Bureau of Occupational and Adult Education (DHEW/OE), Washington, DC. Div. of Research and Demonstration.

    The document on occupational clusters was developed from papers presented in staff seminars in the Bureau of Occupational and Adult Education and contains eight papers: Introduction to the World of Clustering, Sidney C. High; Cluster Curriculum Development, Elizabeth J. Simpson; the Cluster Concept, Development of Curricular Materials for the…

  5. Latin American USOMs Seminar on Agrarian Reform.

    ERIC Educational Resources Information Center

    International Cooperation Administration (Dept. of State), Washington, DC.

    This report of seminar proceedings discusses land reform policies and programs and their place in the economic development of Latin America. It analyzes experiences and current situations in Latin America, the United States, and elsewhere which shed light on the problems and possibilities of agrarian reform. An appraisal of existing physical,…

  6. Report on Fulbright Summer Seminar on Indonesia.

    ERIC Educational Resources Information Center

    Christenson, Charles Elroy

    This resource packet was compiled by a participant in the Fulbright Summer Seminar on Indonesia. The materials provide information for teaching about the diaspora of Hinduism and Islamic beliefs throughout the southeast Asia archipelagoes and their influence on art and culture. The handouts supplement information on Indonesia as part of an Asian…

  7. 2012 National Policy Seminar Wrap-Up

    ERIC Educational Resources Information Center

    Blandford, Ayoka

    2012-01-01

    CTE works! That was the recurring theme that attendees heard at the 2012 National Policy Seminar (NPS) hosted by ACTE. For those new to the event and lobbying, a pre-conference workshop, "Learning the Ropes of Washington CTE Advocacy," laid out the basics of Hill advocacy. Veteran CTE advocates were offered a basics-plus session,…

  8. NASA STI Program Seminar: Electronic documents

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The theme of this NASA Scientific and Technical Information Program Seminar was electronic documents. Topics covered included Electronic Documents Management at the CASI, the Impact of Electronic Publishing on User Expectations and Searching Image Record Management, Secondary Publisher Considerations for Electronic Journal Literature, and the Technical Manual Publishing On Demand System (TMPODS).

  9. English 116: Freshman Seminar--Writing & Photography

    ERIC Educational Resources Information Center

    Leahy, Anna; Rindge, Deborah

    2004-01-01

    English 116: Freshman Seminar is, according to the college catalog, the "gateway course for North Central College's integrative curriculum. [It f]ocuses on writing, reading, and critical thinking related to a specific area of inquiry [and is t]eam-taught by faculty from English and another department. Topics vary, but emphasis is on rhetoric…

  10. The Traveling Seminar -- A Creative Workshop

    ERIC Educational Resources Information Center

    Moehlenbrock, Fred A.

    1973-01-01

    The New Mexico Research and Study Council felt workshops could be fun as well as interesting and educational. In 1972, a conference tour bus, including a library, open and closed circuit television, and other necessary audiovisual equipment, was obtained and the traveling seminar operationalized. Live activities were conducted in the built-in…

  11. LEADERSHIP DEVELOPMENT SEMINAR, VOCATIONAL-TECHNICAL EDUCATION.

    ERIC Educational Resources Information Center

    BEALL, MIRIAM L.; SMITH, CLODUS R.

    FORTY-FIVE VOCATIONAL EDUCATORS PARTICIPATED IN A SEMINAR DESIGNED TO DEVELOP UNDERSTANDINGS, ABILITIES, AND ATTITUDES FOR MORE EFFECTIVE LEADERSHIP BY PROFESSIONAL STATE-LEVEL VOCATIONAL EDUCATION PERSONNEL IN 23 EASTERN STATES, THE DISTRICT OF COLUMBIA, PUERTO RICO, AND THE VIRGIN ISLANDS. SUMMARIES OF THE FOLLOWING PRESENTATIONS ARE INCLUDED…

  12. Folding of polyglutamine chains

    NASA Astrophysics Data System (ADS)

    Chopra, Manan; Reddy, Allam S.; Abbott, N. L.; de Pablo, J. J.

    2008-10-01

    Long polyglutamine chains have been associated with a number of neurodegenerative diseases. These include Huntington's disease, where expanded polyglutamine (PolyQ) sequences longer than 36 residues are correlated with the onset of symptoms. In this paper we study the folding pathway of a 54-residue PolyQ chain into a β-helical structure. Transition path sampling Monte Carlo simulations are used to generate unbiased reactive pathways between unfolded configurations and the folded β-helical structure of the polyglutamine chain. The folding process is examined in both explicit water and an implicit solvent. Both models reveal that the formation of a few critical contacts is necessary and sufficient for the molecule to fold. Once the primary contacts are formed, the fate of the protein is sealed and it is largely committed to fold. We find that, consistent with emerging hypotheses about PolyQ aggregation, a stable β-helical structure could serve as the nucleus for subsequent polymerization of amyloid fibrils. Our results indicate that PolyQ sequences shorter than 36 residues cannot form that nucleus, and it is also shown that specific mutations inferred from an analysis of the simulated folding pathway exacerbate its stability.

  13. Assessment of cancer education seminars for Appalachian populations.

    PubMed

    Katz, Mira L; Pennell, Michael L; Dignan, Mark B; Paskett, Electra D

    2012-06-01

    Cancer education seminars for Appalachian populations were conducted to: (1) increase knowledge of existing cancer disparities, (2) disseminate findings from Appalachian community-based participatory research (CBPR) projects, and (3) foster CBPR capacity building among community members by promoting social networking. Evaluation of the seminars was completed by: (1) using pre-post-surveys to assess changes in knowledge and attitudes at three regional and one national seminar and (2) measuring a change in the social network patterns of participants at a national seminar by analyzing the names of individuals known at the beginning and at the end of the seminar by each participant. Among participants, there was a significant increase in knowledge of Appalachian cancer disparities at two seminars [national, t(145) = 3.41, p = 0.001; Pennsylvania, t(189) = 3.00, p = 0.003] and a change in attitudes about Appalachia at one seminar [Ohio t(193) = -2.80, p = 0.006]. Social network analysis, operationally defined for this study as familiarity with individuals attending the conference, showed participation in the national seminar fostered capacity building for future CBPR by the development of new network ties. Findings indicate that short-term outcomes of the seminars were accomplished. Future educational seminars should consider using social network analysis as a new evaluation methodology.

  14. Programmable matter by folding

    PubMed Central

    Hawkes, E.; An, B.; Benbernou, N. M.; Tanaka, H.; Kim, S.; Demaine, E. D.; Rus, D.; Wood, R. J.

    2010-01-01

    Programmable matter is a material whose properties can be programmed to achieve specific shapes or stiffnesses upon command. This concept requires constituent elements to interact and rearrange intelligently in order to meet the goal. This paper considers achieving programmable sheets that can form themselves in different shapes autonomously by folding. Past approaches to creating transforming machines have been limited by the small feature sizes, the large number of components, and the associated complexity of communication among the units. We seek to mitigate these difficulties through the unique concept of self-folding origami with universal crease patterns. This approach exploits a single sheet composed of interconnected triangular sections. The sheet is able to fold into a set of predetermined shapes using embedded actuation. To implement this self-folding origami concept, we have developed a scalable end-to-end planning and fabrication process. Given a set of desired objects, the system computes an optimized design for a single sheet and multiple controllers to achieve each of the desired objects. The material, called programmable matter by folding, is an example of a system capable of achieving multiple shapes for multiple functions. PMID:20616049

  15. Folding of apominimyoglobin.

    PubMed Central

    De Sanctis, G; Ascoli, F; Brunori, M

    1994-01-01

    The acid unfolding pathway of apominimyoglobin (apo-mini-Mb), a 108-aa fragment (aa 32-139) of horse heart apomyoglobin has been studied by means of circular dichroism, in comparison with the native apoprotein. Similar to sperm whale apomyoglobin [Hughson, F. M., Wright, P. E. & Baldwin, R. L. (1990) Science 249, 1544-1548], a partly folded intermediate (alpha-helical content approximately 35%) is populated at pH 4.2 for horse heart apomyoglobin. For this intermediate, Hughson et al. proposed a structural model with a compact subdomain involving tertiary interactions between the folded A, G, and H helices, with the remainder of the protein essentially unfolded. As described in this paper, a folding intermediate with an alpha-helical content of approximately 33% is populated at pH 4.3-5.0 also in apo-mini-Mb. The acid unfolding pathway is similarly affected in both the native and the mini apoprotein by 15% trifluoroethanol, a helix-stabilizing compound. Thus, the folding of the apo-mini-Mb intermediate is similar to that observed for the native apoprotein, in spite of the absence in the miniprotein of the A helix and of a large part of the H helix, which are crucial for the stability of apo-Mb intermediate. Our results suggest that acquisition of a folded state in apo-mini-Mb occurs through an alternative pathway, which may or may not be shared also by apo-Mb. PMID:7972092

  16. Clean coal technologies---An international seminar: Seminar evaluation and identification of potential CCT markets

    SciTech Connect

    Guziel, K.A.; Poch, L.A.; Gillette, J.L.; Buehring, W.A.

    1991-07-01

    The need for environmentally responsible electricity generation is a worldwide concern. Because coal is available throughout the world at a reasonable cost, current research is focusing on technologies that use coal with minimal environmental effects. The United States government is supporting research on clean coal technologies (CCTs) to be used for new capacity additions and for retrofits to existing capacity. To promote the worldwide adoption of US CCTs, the US Department of Energy, the US Agency for International Development, and the US Trade and Development Program sponsored a two-week seminar titled Clean Coal Technologies -- An International Seminar. Nineteen participants from seven countries were invited to this seminar, which was held at Argonne National Laboratory in June 1991. During the seminar, 11 US CCT vendors made presentations on their state-of-the-art and commercially available technologies. The presentations included technical, environmental, operational, and economic characteristics of CCTs. Information on financing and evaluating CCTs also was presented, and participants visited two CCT operating sites. The closing evaluation indicated that the seminar was a worthwhile experience for all participants and that it should be repeated. The participants said CCT could play a role in their existing and future electric capacity, but they agreed that more CCT demonstration projects were needed to confirm the reliability and performance of the technologies.

  17. 1990 fuel cell seminar: Program and abstracts

    SciTech Connect

    Not Available

    1990-12-31

    This volume contains author prepared short resumes of the presentations at the 1990 Fuel Cell Seminar held November 25-28, 1990 in Phoenix, Arizona. Contained herein are 134 short descriptions organized into topic areas entitled An Environmental Overview, Transportation Applications, Technology Advancements for Molten Carbonate Fuel Cells, Technology Advancements for Solid Fuel Cells, Component Technologies and Systems Analysis, Stationary Power Applications, Marine and Space Applications, Technology Advancements for Acid Type Fuel Cells, and Technology Advancement for Solid Oxide Fuel Cells.

  18. High temperature electronics and instrumentation seminar proceedings

    SciTech Connect

    Veneruso, A.F.; Arnold, C.; Simpson, R.S.

    1980-05-01

    This seminar was tailored to address the needs of the borehole logging industry and to stimulate the development and application of this technology, for logging geothermal, hot oil and gas, and steam injection wells. The technical sessions covered the following topics: hybrid circuits, electronic devices, transducers, cables and connectors, materials, mechanical tools and thermal protection. Thirty-eight papers are included. Separate entries were prepared for each one. (MHR)

  19. Folds and Etudes

    ERIC Educational Resources Information Center

    Bean, Robert

    2007-01-01

    In this article, the author talks about "Folds" and "Etudes" which are images derived from anonymous typing exercises that he found in a used copy of "Touch Typing Made Simple". "Etudes" refers to the musical tradition of studies for a solo instrument, which is a typewriter. Typing exercises are repetitive attempts to type words and phrases…

  20. Modelling of lateral fold growth and fold linkage: Applications to fold-and-thrust belt tectonics

    NASA Astrophysics Data System (ADS)

    Grasemann, Bernhard; Schmalholz, Stefan

    2013-04-01

    We use a finite element model to investigate the three-dimensional fold growth and interference of two initially isolated fold segments. The most critical parameter, which controls the fold linkage mode, is the phase difference between the laterally growing fold hinge lines: 1) "Linear-linkage" yields a sub-cylindrical fold with a saddle at the location where the two initial folds linked. 2) "Oblique-linkage" produces a curved fold resembling a Type II refold structure. 3) "Oblique-no-linkage" results in two curved folds with fold axes plunging in opposite directions. 4) "Linear-no-linkage" yields a fold train of two separate sub-cylindrical folds with fold axes plunging in opposite directions. The transition from linkage to no-linkage occurs when the fold separation between the initially isolated folds is slightly larger than one half of the low-amplitude fold wavelength. The model results compare well with previously published plasticine analogue models and can be directly applied to the investigation of fold growth history in fold-and-thust belts. An excellent natural example of lateral fold linkage is described from the Zagros fold-and-thrust belt in the Kurdistan Region of Iraq. The fold growth in this region is not controlled by major thrust faults but the shortening of the Paleozoic to Cenozoic passive margin sediments of the Arabian plate occurred mainly by detachment folding. The sub-cylindrical anticlines with hinge-parallel lengths of more than 50 km have not developed from single sub-cylindrical embryonic folds but they have merged from different fold segments that joined laterally during fold amplification and lateral fold growth. Linkage points are marked by geomorphological saddle points which are structurally the lowermost points of antiforms and points of principal curvatures with opposite sign. Linkage points can significantly influence the migration of mineral-rich fluids and hydrocarbons and are therefore of great economic importance.

  1. Folded waveguide coupler

    DOEpatents

    Owens, Thomas L.

    1988-03-01

    A resonant cavity waveguide coupler for ICRH of a magnetically confined plasma. The coupler consists of a series of inter-leaved metallic vanes disposed withn an enclosure analogous to a very wide, simple rectangular waveguide that has been "folded" several times. At the mouth of the coupler, a polarizing plate is provided which has coupling apertures aligned with selected folds of the waveguide through which rf waves are launched with magnetic fields of the waves aligned in parallel with the magnetic fields confining the plasma being heated to provide coupling to the fast magnetosonic wave within the plasma in the frequency usage of from about 50-200 mHz. A shorting plate terminates the back of the cavity at a distance approximately equal to one-half the guide wavelength from the mouth of the coupler to ensure that the electric field of the waves launched through the polarizing plate apertures are small while the magnetic field is near a maximum. Power is fed into the coupler folded cavity by means of an input coaxial line feed arrangement at a point which provides an impedance match between the cavity and the coaxial input line.

  2. The protein folding network

    NASA Astrophysics Data System (ADS)

    Rao, Francesco; Caflisch, Amedeo

    2004-03-01

    Networks are everywhere. The conformation space of a 20-residue antiparallel beta-sheet peptide [1], sampled by molecular dynamics simulations, is mapped to a network. Conformations are nodes of the network, and the transitions between them are links. As previously found for the World-Wide Web as well as for social and biological networks , the conformation space contains highly connected hubs like the native state which is the most populated free energy basin. Furthermore, the network shows a hierarchical modularity [2] which is consistent with the funnel mechanism of folding [3] and is not observed for a random heteropolymer lacking a native state. Here we show that the conformation space network describes the free energy landscape without requiring projections into arbitrarily chosen reaction coordinates. The network analysis provides a basis for understanding the heterogeneity of the folding transition state and the existence of multiple pathways. [1] P. Ferrara and A. Caflisch, Folding simulations of a three-stranded antiparallel beta-sheet peptide, PNAS 97, 10780-10785 (2000). [2] Ravasz, E. and Barabási, A. L. Hierarchical organization in complex networks. Phys. Rev. E 67, 026112 (2003). [3] Dill, K. and Chan, H From Levinthal to pathways to funnels. Nature Struct. Biol. 4, 10-19 (1997)

  3. Ab initio RNA folding

    NASA Astrophysics Data System (ADS)

    Cragnolini, Tristan; Derreumaux, Philippe; Pasquali, Samuela

    2015-06-01

    RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, the experimental determination of RNA structures through x-ray crystallography and NMR seems to have reached a plateau in the number of structures resolved each year, but as more and more RNA sequences are being discovered, the need for structure prediction tools to complement experimental data is strong. Theoretical approaches to RNA folding have been developed since the late nineties, when the first algorithms for secondary structure prediction appeared. Over the last 10 years a number of prediction methods for 3D structures have been developed, first based on bioinformatics and data-mining, and more recently based on a coarse-grained physical representation of the systems. In this review we are going to present the challenges of RNA structure prediction and the main ideas behind bioinformatic approaches and physics-based approaches. We will focus on the description of the more recent physics-based phenomenological models and on how they are built to include the specificity of the interactions of RNA bases, whose role is critical in folding. Through examples from different models, we will point out the strengths of physics-based approaches, which are able not only to predict equilibrium structures, but also to investigate dynamical and thermodynamical behavior, and the open challenges to include more key interactions ruling RNA folding.

  4. Ab initio RNA folding.

    PubMed

    Cragnolini, Tristan; Derreumaux, Philippe; Pasquali, Samuela

    2015-06-17

    RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, the experimental determination of RNA structures through x-ray crystallography and NMR seems to have reached a plateau in the number of structures resolved each year, but as more and more RNA sequences are being discovered, the need for structure prediction tools to complement experimental data is strong. Theoretical approaches to RNA folding have been developed since the late nineties, when the first algorithms for secondary structure prediction appeared. Over the last 10 years a number of prediction methods for 3D structures have been developed, first based on bioinformatics and data-mining, and more recently based on a coarse-grained physical representation of the systems. In this review we are going to present the challenges of RNA structure prediction and the main ideas behind bioinformatic approaches and physics-based approaches. We will focus on the description of the more recent physics-based phenomenological models and on how they are built to include the specificity of the interactions of RNA bases, whose role is critical in folding. Through examples from different models, we will point out the strengths of physics-based approaches, which are able not only to predict equilibrium structures, but also to investigate dynamical and thermodynamical behavior, and the open challenges to include more key interactions ruling RNA folding.

  5. The Graduate Seminar: Another Research-Process Genre.

    ERIC Educational Resources Information Center

    Weissberg, Bob

    1993-01-01

    A qualitative study is described investigating the university graduate student seminar presentation as a speech event and its status as a genre. Findings support Swales' (1990) contention that the graduate seminar is an independent genre related to the experimental research article, not merely an oral replication. (20 references) (Author/LB)

  6. 75 FR 70725 - Spectrum Policy Seminar for the Utility Sector

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... Spectrum Policy Seminar for the Utility Sector AGENCY: Department of Energy. ACTION: Notice of public... . One recommendation in the report was to provide more information to the utility sector on spectrum... grid technologies. At this spectrum policy seminar, senior officials from the Federal...

  7. The Women's Studies Senior Seminar 1976-77.

    ERIC Educational Resources Information Center

    Register, Cheri; And Others

    This paper describes and evaluates two courses comprising a senior seminar designed as the culmination of a women's studies curriculum. Interdisciplinary in nature and team-taught, the seminar included studies from the fields of literature, psychology, and anthropology. The theme of the Winter 1977 course was "Women, Culture, and Power." Lectures…

  8. Teaching Controversy by Seminar: An Example in Quaternary Geomorphology.

    ERIC Educational Resources Information Center

    Harwood, Doug

    1987-01-01

    Describes how seminar work can be structured to help students develop skills of critical thinking and expression when discussing controversial issues in their chosen subject. Particular emphasis is given to methods of organizing instructional materials and appropriate roles for seminar leaders. The debate surrounding the existence of a prehistoric…

  9. Improving Higher Education in Developing Countries. EDI Seminar Series.

    ERIC Educational Resources Information Center

    Ransom, Angela; And Others

    This volume is the result of a policy seminar on Improvement and Innovation in Higher Education in Developing Countries, organized by the Economic Development Institute and the Population and Human Resources Department of the World Bank in collaboration with the Institute of Strategic and International Studies of Malaysia. The seminar was held in…

  10. International Trade Seminar (Austin, Texas, December 2, 1988).

    ERIC Educational Resources Information Center

    Midland Coll., TX. Business and Economic Development Center.

    Selected presentations from a 1988 seminar on international trade hosted by Midland College (MC) are included in this report. Designed to direct west Texas businesses toward diversification and to prepare them for international trade and business opportunities, the seminar featured speakers in the field of international trade, including bank…

  11. Having a Graduate Seminar "With" Rather Than "From"

    ERIC Educational Resources Information Center

    Morris, William E.

    1975-01-01

    The educational objectives and techniques for the graduate seminar are outlined and illustrated with material from a successful seminar on The World of John Donne. Included is discussion of selecting an appropriate topic, use of guest lecturers, students working as a team, and the teacher's role. Emphasis is on shared research. (JT)

  12. Integrating Webinar and Blogging Technologies into Chemistry Seminar

    ERIC Educational Resources Information Center

    Hamstra, Dan; Kemsley, Jyllian N.; Murray, Desmond H.; Randall, David W.

    2011-01-01

    We report successfully integrating webinar and blogging into an undergraduate chemistry and biochemistry seminar course. Commercial collaboration software linked speaker-operated slides with two-way voice and video effectively connecting the audience and presenter from different states. Student responses to the technology and seminar content were…

  13. Strategies and Tactics for Community Mobilization. 1981 Latin America Seminars.

    ERIC Educational Resources Information Center

    Dobson, John R. A.

    Three seminars examined strategies and tactics for community mobilization in Latin America. The sessions--which were held in Bogota, Columbia; Quito, Ecuador; and Recife, Brazil--involved a total of 75 participants from 27 organizations. Addressed during the seminars were development, leadership, mobilization, and learning in the context of…

  14. Organizing a Campus Seminar on Careers in Entertainment.

    ERIC Educational Resources Information Center

    Walt Disney Productions, Anaheim, CA.

    Developed by Walt Disney Productions as part of a project granted by the Career Education Program of the Office of Education, this handbook is designed to help college and university fine arts departments in planning and carrying out an on-campus seminar on careers in entertainment. Sections include Why Hold a Seminar on Careers in Entertainment?,…

  15. How to Construct and Analyze Proofs--A Seminar Course.

    ERIC Educational Resources Information Center

    Reisel, Robert B.

    1982-01-01

    Details are provided of a seminar conducted at Loyola University on the construction and criticism of proofs. The seminar is geared towards sophomore mathematics and computer science majors. It is felt that the approach fills an important need in the mathematics curriculum. (MP)

  16. Negotiating Meaning in a Seminar-Type Discussion and EAP.

    ERIC Educational Resources Information Center

    Basturkmen, Helen

    2002-01-01

    Reports on a study exploring patterns of discourse organization in seminar-type discussions. Analysis was made of patterns of sequential organization in discussions between English for academic purposes students in university seminars in the United Kingdom. Analysis revealed two patterns of organization: simple exchanges of pre-formed ideas and…

  17. A Course in Heterogeneous Catalysis Involving Video-Based Seminars.

    ERIC Educational Resources Information Center

    White, Mark G.

    1984-01-01

    A video-based format was used during a graduate seminar course designed to educate students on the nature of catalysis, to help transfer information among students working on similar problems, and to improve communication skills. The mechanics of and student reaction to this seminar course are discussed. (JN)

  18. SEMINAR PUBLICATION: OPERATIONAL PARAMETERS FOR HAZARDOUS WASTE COMBUSTION DEVICES

    EPA Science Inventory

    The information in the document is based on presentations at the EPA-sponsored seminar series on Operational Parameters for Hazardous Waste Combustion Devices. This series consisted of five seminars held in 1992. Hazardous waste combustion devices are regulated under the Resource...

  19. The Peer Seminar, a Spoken Research Process Genre

    ERIC Educational Resources Information Center

    Aguilar, Marta

    2004-01-01

    This study aims to report on another research process genre, namely the peer seminar. Work exists [English for Specific Purposes, 12 (1993) 23; 18 (1999) 63] which studies different aspects of the seminar as understood in the Anglo-Saxon world (an expert-to-novice situation with an asymmetrical status of participants) but little attention has been…

  20. An Experimental Comparison of Retirement Planning Intervention Seminars.

    ERIC Educational Resources Information Center

    Hershey, Douglas A.; Mowen, John C.; Jacobs-Lawson, Joy M.

    2003-01-01

    After 1 year, the efficacy of three retirement seminars (financial planning information, n=30; financial goal-setting, n=25; combined information and goal-setting, n=25) was measured. Compared to those of 26 controls, goal clarity, planning, and savings practices of seminar participants were most changed. Strongest impact was on those in combined…

  1. 2015 Cross-Domain Deterrence Seminar Summary Report

    SciTech Connect

    Juarez, A.

    2016-01-11

    Lawrence Livermore National Laboratory (LLNL) hosted the 2nd Annual Cross-Domain Deterrence Seminar on November 17th, 2015 in Livermore, CA. The seminar was sponsored by LLNL’s Center for Global Security Research (CGSR), National Security Office (NSO), and Global Security program. This summary covers the seminar’s panels and subsequent discussions.

  2. Varying Formats for Two-Year-College Honors Seminars

    ERIC Educational Resources Information Center

    Rosenow, Ce; Morrison-Graham, Katie; Ozolins, Erik G.

    2016-01-01

    Honors programs at two-year colleges vary substantially in scope, size, and structure depending on an individual college's mission, campus culture, and budget. One common curricular feature, however, is the honors seminar. However, little information is available on creating honors seminars at two-year schools. Our essay responds to this deficit…

  3. Fuel Cell Seminar, 1992: Program and abstracts

    SciTech Connect

    Not Available

    1992-12-31

    This year`s theme, ``Fuel Cells: Realizing the Potential,`` focuses on progress being made toward commercial manufacture and use of fuel cell products. Fuel cell power plants are competing for market share in some applications and demonstrations of market entry power plants are proceeding for additional applications. Development activity on fuel cells for transportation is also increasing; fuel cell products have potential in energy and transportation industries, with very favorable environmental impacts. This Seminar has the purpose of fostering communication by providing a forum for the international community interested in development, application, and business opportunities related fuel cells. Over 190 technical papers are included, the majority being processed for the data base.

  4. United States-Japan Seminar on Science Education. Seminar Summary, Conclusions, and Recommendations (Honolulu, Hawaii, September 14-20, 1986).

    ERIC Educational Resources Information Center

    1986

    The United States-Japan Cooperative Science Program was initiated for the purpose of conducting research and exchanging ideas for the improvement of science education. A seminar was held in Honolulu in 1986 to discuss efforts and future directions of this cooperative program. This paper reviews the outcomes of the seminar in three areas. These…

  5. Seminar on Financing Education: The Budgetary Process Under Pressure. Proceedings of a Seminar (Ottawa, Ontario, March 1-2, 1976).

    ERIC Educational Resources Information Center

    Canadian Teachers' Federation, Ottawa (Ontario).

    The purpose of this seminar was to give members of the Canadian Teachers' Federation a better understanding of the educational budgetary process. The proceedings of the seminar included welcoming remarks by Russell D. Mosher followed by two addresses--"The Political Context of Budgeting" by Dr. Peter Atherton and "Resource…

  6. Information from folds: A review

    NASA Astrophysics Data System (ADS)

    Hudleston, Peter J.; Treagus, Susan H.

    2010-12-01

    Folds are spectacular geological structures that are seen in layered rock on many different scales. To mark 30 years of the Journal of Structural Geology, we review the information that can be gained from studies of folds in theory, experiment and nature. We first review theoretical considerations and modeling, from classical approaches to current developments. The subject is dominated by single-layer fold theory, with the assumption of perfect layer-parallel shortening, but we also review multilayer fold theory and modeling, and folding of layers that are oblique to principal stresses and strains. This work demonstrates that viscosity ratio, degree of non-linearity of the flow law, anisotropy, and the thickness and spacing distribution of layers of different competence are all important in determining the nature and strength of the folding instability. Theory and modeling provide the basis for obtaining rheological information from natural folds, through analysis of wavelength/thickness ratios of single layer folds, and fold shapes. They also provide a basis for estimating the bulk strain from folded layers. Information about folding mechanisms can be obtained by analysis of cleavage and fabric patterns in folded rocks, and the history of deformation can be revealed by understanding how asymmetry can develop in folds, by how folds develop in shear zones, and how folds develop in more complex three-dimensional deformations.

  7. Folding above faults, Rocky Mountains

    SciTech Connect

    McConnell, D.A. . Dept. of Geology)

    1992-01-01

    Asymmetric folds formed above basement faults can be observed throughout the Rocky Mountains. Several previous interpretations of the folding process made the implicit assumption that one or both fold hinges migrated or rolled'' through the steep forelimb of the fold as the structure evolved (rolling hinge model). Results of mapping in the Bighorn and Seminoe Mountains, WY, and Sangre de Cristo Range, CO, do not support this hypothesis. An alternative interpretation is presented in which fold hinges remained fixed in position during folding (fixed hinge model). Mapped folds share common characteristics: (1) axial traces of the folds intersect faults at or near the basement/cover interface, and diverge from faults upsection; (2) fold hinges are narrow and interlimb angles cluster around 80--100[degree] regardless of fold location; (3) fold shape is typically angular, despite published cross sections that show concentric folds; and, (4) beds within the folds show thickening and/or thinning, most commonly adjacent to fold hinges. The rolling hinge model requires that rocks in the fold forelimbs bend through narrow fold hinges as deformation progressed. Examination of massive, competent rock units such as the Ord. Bighorn Dolomite, Miss. Madison Limestone, and, Penn. Tensleep Sandstone reveals no evidence of the extensive internal deformation that would be expected if hinges rolled through rocks of the forelimb. The hinges of some folds (e.g. Golf Creek anticline, Bighorn Mountains) are offset by secondary faults, effectively preventing the passage of rocks from backlimb to forelimb. The fixed hinge model proposes that the fold hinges were defined early in fold evolution, and beds were progressively rotated and steepened as the structure grew.

  8. Wind Turbine Tribology Seminar - A Recap

    SciTech Connect

    Errichello, R.; Sheng, S.; Keller, J.; Greco, A.

    2012-02-01

    Tribology is the science and engineering of interacting surfaces in relative motion. It includes the study and application of the principles of friction, lubrication, and wear. It is an important phenomenon that not only impacts the design and operation of wind turbine gearboxes, but also their subsequent maintenance requirements and overall reliability. With the major growth and increasing dependency on renewable energy, mechanical reliability is an extremely important issue. The Wind Turbine Tribology Seminar was convened to explore the state-of-the-art in wind turbine tribology and lubricant technologies, raise industry awareness of a very complex topic, present the science behind each technology, and identify possible R&D areas. To understand the background of work that had already been accomplished, and to consolidate some level of collective understanding of tribology by acknowledged experts, the National Renewable Energy Laboratory (NREL), Argonne National Laboratory (ANL), and the U.S. Department of Energy (DOE) hosted a wind turbine tribology seminar. It was held at the Renaissance Boulder Flatiron Hotel in Broomfield, Colorado on November 15-17, 2011. This report is a summary of the content and conclusions. The presentations given at the meeting can be downloaded. Interested readers who were not at the meeting may wish to consult the detailed publications listed in the bibliography section, obtain the cited articles in the public domain, or contact the authors directly.

  9. A Seminar Course on Contemporary Pharmacy Issues

    PubMed Central

    2008-01-01

    Objectives To implement and evaluate an innovative approach to a pharmacy seminar course intended to develop students' presentation skills and encourage them to think critically about contemporary pharmacy issues. Design The instructor provided lectures intended to prepare students for their presentations. These lectures included tips on writing abstracts, learning objectives, use of visual aids, and presentation delivery. Pairs of students chose a pharmacy issue, researched their topic including identifying various strengths of evidence to support a perspective, wrote an abstract and learning objectives, prepared their visual aids, and delivered a pro/con perspective. Students also provided peer evaluations for these presentations. A personal response system was used to provide class input on the presentations. Assessment Ninety-five percent of the peer evaluations of the presentations were good to excellent. The overall course evaluations indicated achievement of course goals. Conclusions A pharmacy seminar course intended to develop student presentation skills and critical thinking about contemporary pharmacy issues was demonstrated to be successful. The “taking sides” format was an effective design for accomplishing these objectives. PMID:18483598

  10. Folds on Europa

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This image, acquired by NASA's Galileo spacecraft on September 26, 1998, shows features on the surface of Jupiter's moon Europa that a scientific report published today interprets as signs of compressive folding.

    The imaged area is in the Astypalaea Linea region of Europa's southern hemisphere, seen with low-angle sunshine coming from the upper right. North is toward the top.

    Astypalaea Linea is the smooth, gray area that stretches from north to south across the image mosaic. It is thought to have formed by a combination of pulling apart and sliding of the icy surface. The telltale fold features are within the smoother portions of the surface between the more dominant ridges, which are attributed to upwelling of material through surface ice. In the smooth areas, the surface has gentle swells and dips, which show most clearly in the version on the right, processed to accentuate broader-scale shapes. For example, a dip about 15 kilometers (about 10 miles) wide cuts diagonally across the northern half of the largest smooth area, and a rise runs parallel to that in the southern half of the smooth area. closeup detail

    Louise M. Prockter, at Johns Hopkins University, and Robert T. Pappalardo, at Brown University, report in the journal Science today that those rises, or anticlines, and dips, or synclines, appear to be the result of compression causing the crust to fold.

    Additional evidence comes from smaller features more visible in the version on the left, covering the same area. At the crest of the gentle rise in the largest smooth area are small fractures that could be caused by the stretching stress of bending the surface layer upwards. Similarly, at the bottom of the adjacent dip are small, wrinkle-like ridges that could be caused by stress from bending the surface layer downwards.

    The Jet Propulsion Laboratory, Pasadena, Calif., manages the Galileo mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California

  11. Protein photo-folding and quantum folding theory.

    PubMed

    Luo, Liaofu

    2012-06-01

    The rates of protein folding with photon absorption or emission and the cross section of photon -protein inelastic scattering are calculated from quantum folding theory by use of a field-theoretical method. All protein photo-folding processes are compared with common protein folding without the interaction of photons (non-radiative folding). It is demonstrated that there exists a common factor (thermo-averaged overlap integral of the vibration wave function, TAOI) for protein folding and protein photo-folding. Based on this finding it is predicted that (i) the stimulated photo-folding rates and the photon-protein resonance Raman scattering sections show the same temperature dependence as protein folding; (ii) the spectral line of the electronic transition is broadened to a band that includes an abundant vibration spectrum without and with conformational transitions, and the width of each vibration spectral line is largely reduced. The particular form of the folding rate-temperature relation and the abundant spectral structure imply the existence of quantum tunneling between protein conformations in folding and photo-folding that demonstrates the quantum nature of the motion of the conformational-electronic system.

  12. Integrating industrial seminars within a graduate engineering programme

    NASA Astrophysics Data System (ADS)

    Ringwood, John. V.

    2013-05-01

    The benefit of external, often industry-based, speakers for a seminar series associated with both undergraduate and graduate programmes is relatively unchallenged. However, the means by which such a seminar series can be encapsulated within a structured learning module, and the appropriate design of an accompanying assessment methodology, is not so obvious. This paper examines how such a learning module can be formulated and addresses the main issues involved in the design of such a module, namely the selection of speakers, format of seminars, method of delivery and assessment methodology, informed by the objectives of the module.

  13. Seminar on building codes and standards

    SciTech Connect

    Not Available

    1980-01-01

    A seminar was conducted for state building code officials and state energy officials to discuss the following: status of the states regulatory activities for energy conservation standards for buildings; the development, administration, and enforcement processes for energy conservation standards affecting new construction; lighting and thermal standards for existing buildings; status of the development and implementation of the Title III Program, Building Energy Performance Standards (BEPS); and current status of the State Energy Conservation Program. The welcoming address was given by John Wenning and the keynote address was delivered by John Millhone. Four papers presented were: Building Energy Performance Standards Development, James Binkley; Lighting Standards in Existing Buildings, Dorothy Cronheim; Implementation of BEPS, Archie Twitchell; Sanctions for Building Energy Performance Standards, Sue Sicherman.

  14. Folded dielectric elastomer actuators

    NASA Astrophysics Data System (ADS)

    Carpi, Federico; Salaris, Claudio; DeRossi, Danilo

    2007-04-01

    Polymer-based linear actuators with contractile ability are currently demanded for several types of applications. Within the class of dielectric elastomer actuators, two basic configurations are available today for such a purpose: the multi-layer stack and the helical structure. The first consists of several layers of elementary planar actuators stacked in series mechanically and parallel electrically. The second configuration relies on a couple of helical compliant electrodes alternated with a couple of helical dielectrics. The fabrication of both these configurations presents some specific drawbacks today, arising from the peculiarity of each structure. Accordingly, the availability of simpler solutions may boost the short-term use of contractile actuators in practical applications. For this purpose, a new configuration is here described. It consists of a monolithic structure made of an electroded sheet, which is folded up and compacted. The resulting device is functionally equivalent to a multi-layer stack with interdigitated electrodes. However, with respect to a stack the new configuration is advantageously not discontinuous and can be manufactured in one single phase, avoiding layer-by-layer multi-step procedures. The development and preliminary testing of prototype samples of this new actuator made of a silicone elastomer are presented here.

  15. How the genome folds

    NASA Astrophysics Data System (ADS)

    Lieberman Aiden, Erez

    2012-02-01

    I describe Hi-C, a novel technology for probing the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. Working with collaborators at the Broad Institute and UMass Medical School, we used Hi-C to construct spatial proximity maps of the human genome at a resolution of 1Mb. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and closed chromatin to form two genome-wide compartments. At the megabase scale, the chromatin conformation is consistent with a fractal globule, a knot-free conformation that enables maximally dense packing while preserving the ability to easily fold and unfold any genomic locus. The fractal globule is distinct from the more commonly used globular equilibrium model. Our results demonstrate the power of Hi-C to map the dynamic conformations of whole genomes.

  16. Margaret Mead's Evaluation of the First Salzburg Seminar.

    ERIC Educational Resources Information Center

    Russon, Craig; Ryback, Timothy

    2003-01-01

    Discusses the evaluation by Margaret Mead of the first Salzburg Seminar, an educational initiative undertaken to increase global understanding by broadening the perspectives of future leaders. Also describes Mead's evaluation methods. (SLD)

  17. An Interdisciplinary Seminar on Legal Issues in Medicine.

    ERIC Educational Resources Information Center

    Moore, Dale L.

    1989-01-01

    A seminar on legal issues in medicine brings together medical (obstetrics/gynecology) and law students to promote mutual understanding of the legal and medical realms, their effects on each other, and the potential for cooperation. (MSE)

  18. Ethos in Fukushima and the ICRP dialogue seminars.

    PubMed

    Ando, R

    2016-01-01

    Ethos in Fukushima, a non-profit organisation, participated in 10 of the 12 International Commission on Radiological Protection (ICRP) dialogue seminars over the past 4 years. The slides and videos that were shown at the seminars are recorded on the Ethos in Fukushima website ( http://ethos-fukushima.blogspot.jp/p/icrp-dialogue.html ). I would like to introduce the activities of Ethos in Fukushima to date, and explain why the ICRP dialogue materials have come to be published on its website.

  19. High School and Community College Astronomy Research Seminar

    NASA Astrophysics Data System (ADS)

    Genet, Russell M.; Boyce, Pat; Buchheim, Robert; Collins, Dwight; Freed, Rachel; Harshaw, Richard; Johnson, Jolyon; Kenney, John; Wallen, Vera

    2016-06-01

    For the past decade, Cuesta College has held an Astronomy Research Seminar. Teams of high school and community college students, with guidance from instructors and advanced amateur astronomers, have made astronomical observations, reduced their data, and submitted their research results to appropriate journals. A variety of projects, using modest-aperture telescopes equipped with low-cost instruments, are within reach of motivated students. These include double star astrometry, variable star photometry, and exoplanet transit timing. Advanced scientific knowledge and mastery of sophisticated experimental skills are not required when the students are immersed within a supportive community of practice. The seminar features self-paced, online learning units, an online textbook (the Small Telescope Astronomical Research Handbook), and a supportive website sponsored by the Institute for Student Astronomical Research (www.In4StAR.org). There are no prerequisites for the seminar. This encourages everyone—including underrepresented minorities and persons with disabilities—to participate. Each participant contributes as their time, talents, and experience dictates, thus replicating the modern, professional research team. Our spring 2015 seminar was the largest yet. Volunteer assistant instructors provided local in-person leadership, while the entire seminar met online for PowerPoint presentations on proposed projects and final research results. Some 37 students from eight schools finished the seminar as coauthors of 19 papers published in the January 2016 volume of the Journal of Double Star Observations. Robotic telescopes devoted to student research are coming online at both Concordia University and the Boyce Astronomical Robotic Observatory, as is a central online sever that will provide students with uniform, cost-free reduction and analysis software. The seminar has motivated many of its graduates to pursue careers in science, engineering, and medicine, often with

  20. Seminars of Applied Physics, Materials Physics and Biomedical Engineering, 1989

    NASA Astrophysics Data System (ADS)

    Katila, T.; Hautala, M.

    1989-05-01

    The seminars of Applied Physics, Materials Physics and Biomedical Engineering were arranged in 1989 as one common seminar. This report consists of the talks prepared by students as partial fulfillment of their M.Sc. degrees. Topics include: (1) High temperature superconductors; (2) Solid state surface analysis methods; (3) Dispersion in Poiseuille flow; (4) Identification of the ion channel types (Medical applications); (5) Hyperthermia; (6) Resolving of tone frequencies in the vertebrate ear; and (7) Noninvasive electromagnetic location (Medical applications).

  1. The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success: Volume Five: Assessing the First-Year Seminar

    ERIC Educational Resources Information Center

    Friedman, Daniel B.

    2012-01-01

    "The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success," a five-volume series, is designed to assist educators who are interested in launching a first-year seminar or revamping an existing program. Each volume examines a different aspect of first-year seminar design or…

  2. Predicting protein folds with fold-specific PSSM libraries.

    PubMed

    Hong, Yoojin; Chintapalli, Sree Vamsee; Ko, Kyung Dae; Bhardwaj, Gaurav; Zhang, Zhenhai; van Rossum, Damian; Patterson, Randen L

    2011-01-01

    Accurately assigning folds for divergent protein sequences is a major obstacle to structural studies. Herein, we outline an effective method for fold recognition using sets of PSSMs, each of which is constructed for different protein folds. Our analyses demonstrate that FSL (Fold-specific Position Specific Scoring Matrix Libraries) can predict/relate structures given only their amino acid sequences of highly divergent proteins. This ability to detect distant relationships is dependent on low-identity sequence alignments obtained from FSL. Results from our experiments demonstrate that FSL perform well in recognizing folds from the "twilight-zone" SABmark dataset. Further, this method is capable of accurate fold prediction in newly determined structures. We suggest that by building complete PSSM libraries for all unique folds within the Protein Database (PDB), FSL can be used to rapidly and reliably annotate a large subset of protein folds at proteomic level. The related programs and fold-specific PSSMs for our FSL are publicly available at: http://ccp.psu.edu/download/FSLv1.0/.

  3. Evolutionary Optimization of Protein Folding

    PubMed Central

    Debès, Cédric; Wang, Minglei; Caetano-Anollés, Gustavo; Gräter, Frauke

    2013-01-01

    Nature has shaped the make up of proteins since their appearance, 3.8 billion years ago. However, the fundamental drivers of structural change responsible for the extraordinary diversity of proteins have yet to be elucidated. Here we explore if protein evolution affects folding speed. We estimated folding times for the present-day catalog of protein domains directly from their size-modified contact order. These values were mapped onto an evolutionary timeline of domain appearance derived from a phylogenomic analysis of protein domains in 989 fully-sequenced genomes. Our results show a clear overall increase of folding speed during evolution, with known ultra-fast downhill folders appearing rather late in the timeline. Remarkably, folding optimization depends on secondary structure. While alpha-folds showed a tendency to fold faster throughout evolution, beta-folds exhibited a trend of folding time increase during the last 1.5 billion years that began during the “big bang” of domain combinations. As a consequence, these domain structures are on average slow folders today. Our results suggest that fast and efficient folding of domains shaped the universe of protein structure. This finding supports the hypothesis that optimization of the kinetic and thermodynamic accessibility of the native fold reduces protein aggregation propensities that hamper cellular functions. PMID:23341762

  4. Detachment folding, fold amplification, and diapirism in thrust wedge experiments

    NASA Astrophysics Data System (ADS)

    Bonini, Marco

    2003-12-01

    The relations between detachment folding, fold amplification, and salt diapirism in contractional settings have been investigated by means of scaled analogue models. The viscosity of the silicone layer simulating salt in nature and the shortening rates were combined in order to reproduce weak (type 1 models) and strong (type 2 models) décollements. Deformation patterns in the roof sequence exhibited two contrasting styles, (1) outward propagation of detachment folding along the décollement (OFP mode) and (2) passive roof duplex (PRD mode). In type 2 models, detachment folding propagated away from the most external thrust in the floor sequence, while in type 1 models, long-lived detachment folds almost invariably localized amplified above a floor thrust tip as a result of strain localization. A silicone wall intruded occasionally into the crestal graben of detachment folds in type 1 and OFP models. Best fitting of transition models data points indicates nonlinear relations with regression curves close to the equilateral hyperbola equation for both OFP-PRD and amplified detachment folds-box folds transitions. A quantitative comparison of model results with nature has been attempted by plotting salt-based fold-and-thrust belts data points on the scaled transition curves obtained from the modeling. Such a comparison relates shear stress products and ratios to the conditions favoring the amplification of detachment folds and the potential emplacement of ductile diapirs in their core. By reducing the roof sequence strength, pore fluid pressure λb is inferred to shift the equilibrium of fold-and-thrust belts toward the field of OFP and diapirism.

  5. Graphene folding on flat substrates

    SciTech Connect

    Chen, Xiaoming; Zhao, Yadong; Ke, Changhong; Zhang, Liuyang; Wang, Xianqiao

    2014-10-28

    We present a combined experimental-theoretical study of graphene folding on flat substrates. The structure and deformation of the folded graphene sheet are experimentally characterized by atomic force microscopy. The local graphene folding behaviors are interpreted based on nonlinear continuum mechanics modeling and molecular dynamics simulations. Our study on self-folding of a trilayer graphene sheet reports a bending stiffness of about 6.57 eV, which is about four times the reported values for monolayer graphene. Our results reveal that an intriguing free sliding phenomenon occurs at the interlayer van der Waals interfaces during the graphene folding process. This work demonstrates that it is a plausible venue to quantify the bending stiffness of graphene based on its self-folding conformation on flat substrates. The findings reported in this work are useful to a better understanding of the mechanical properties of graphene and in the pursuit of its applications.

  6. Compact intermediates in RNA folding

    SciTech Connect

    Woodson, S.A.

    2011-12-14

    Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transition, which coincides with the assembly of helical domains, depends on RNA sequence and counterions. It determines the specificity of the folding pathways and the magnitude of the free energy barriers to the ensuing search for the native conformation. By coupling helix assembly with nascent tertiary interactions, compact folding intermediates in RNA also play a crucial role in ligand binding and RNA-protein recognition.

  7. Changes of protein stiffness during folding detect protein folding intermediates.

    PubMed

    Małek, Katarzyna E; Szoszkiewicz, Robert

    2014-01-01

    Single-molecule force-quench atomic force microscopy (FQ-AFM) is used to detect folding intermediates of a simple protein by detecting changes of molecular stiffness of the protein during its folding process. Those stiffness changes are obtained from shape and peaks of an autocorrelation of fluctuations in end-to-end length of the folding molecule. The results are supported by predictions of the equipartition theorem and agree with existing Langevin dynamics simulations of a simplified model of a protein folding. In the light of the Langevin simulations the experimental data probe an ensemble of random-coiled collapsed states of the protein, which are present both in the force-quench and thermal-quench folding pathways.

  8. Structural Bridges through Fold Space

    PubMed Central

    Edwards, Hannah; Deane, Charlotte M.

    2015-01-01

    Several protein structure classification schemes exist that partition the protein universe into structural units called folds. Yet these schemes do not discuss how these units sit relative to each other in a global structure space. In this paper we construct networks that describe such global relationships between folds in the form of structural bridges. We generate these networks using four different structural alignment methods across multiple score thresholds. The networks constructed using the different methods remain a similar distance apart regardless of the probability threshold defining a structural bridge. This suggests that at least some structural bridges are method specific and that any attempt to build a picture of structural space should not be reliant on a single structural superposition method. Despite these differences all representations agree on an organisation of fold space into five principal community structures: all-α, all-β sandwiches, all-β barrels, α/β and α + β. We project estimated fold ages onto the networks and find that not only are the pairings of unconnected folds associated with higher age differences than bridged folds, but this difference increases with the number of networks displaying an edge. We also examine different centrality measures for folds within the networks and how these relate to fold age. While these measures interpret the central core of fold space in varied ways they all identify the disposition of ancestral folds to fall within this core and that of the more recently evolved structures to provide the peripheral landscape. These findings suggest that evolutionary information is encoded along these structural bridges. Finally, we identify four highly central pivotal folds representing dominant topological features which act as key attractors within our landscapes. PMID:26372166

  9. Pseudoknots in RNA folding landscapes

    PubMed Central

    Kucharík, Marcel; Hofacker, Ivo L.; Stadler, Peter F.; Qin, Jing

    2016-01-01

    Motivation: The function of an RNA molecule is not only linked to its native structure, which is usually taken to be the ground state of its folding landscape, but also in many cases crucially depends on the details of the folding pathways such as stable folding intermediates or the timing of the folding process itself. To model and understand these processes, it is necessary to go beyond ground state structures. The study of rugged RNA folding landscapes holds the key to answer these questions. Efficient coarse-graining methods are required to reduce the intractably vast energy landscapes into condensed representations such as barrier trees or basin hopping graphs (BHG) that convey an approximate but comprehensive picture of the folding kinetics. So far, exact and heuristic coarse-graining methods have been mostly restricted to the pseudoknot-free secondary structures. Pseudoknots, which are common motifs and have been repeatedly hypothesized to play an important role in guiding folding trajectories, were usually excluded. Results: We generalize the BHG framework to include pseudoknotted RNA structures and systematically study the differences in predicted folding behavior depending on whether pseudoknotted structures are allowed to occur as folding intermediates or not. We observe that RNAs with pseudoknotted ground state structures tend to have more pseudoknotted folding intermediates than RNAs with pseudoknot-free ground state structures. The occurrence and influence of pseudoknotted intermediates on the folding pathway, however, appear to depend very strongly on the individual RNAs so that no general rule can be inferred. Availability and implementation: The algorithms described here are implemented in C++ as standalone programs. Its source code and Supplemental material can be freely downloaded from http://www.tbi.univie.ac.at/bhg.html. Contact: qin@bioinf.uni-leipzig.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID

  10. How Does Your Protein Fold? Elucidating the Apomyoglobin Folding Pathway.

    PubMed

    Dyson, H Jane; Wright, Peter E

    2017-01-17

    Although each type of protein fold and in some cases individual proteins within a fold classification can have very different mechanisms of folding, the underlying biophysical and biochemical principles that operate to cause a linear polypeptide chain to fold into a globular structure must be the same. In an aqueous solution, the protein takes up the thermodynamically most stable structure, but the pathway along which the polypeptide proceeds in order to reach that structure is a function of the amino acid sequence, which must be the final determining factor, not only in shaping the final folded structure, but in dictating the folding pathway. A number of groups have focused on a single protein or group of proteins, to determine in detail the factors that influence the rate and mechanism of folding in a defined system, with the hope that hypothesis-driven experiments can elucidate the underlying principles governing the folding process. Our research group has focused on the folding of the globin family of proteins, and in particular on the monomeric protein apomyoglobin. Apomyoglobin (apoMb) folds relatively slowly (∼2 s) via an ensemble of obligatory intermediates that form rapidly after the initiation of folding. The folding pathway can be dissected using rapid-mixing techniques, which can probe processes in the millisecond time range. Stopped-flow measurements detected by circular dichroism (CD) or fluorescence spectroscopy give information on the rates of folding events. Quench-flow experiments utilize the differential rates of hydrogen-deuterium exchange of amide protons protected in parts of the structure that are folded early; protection of amides can be detected by mass spectrometry or proton nuclear magnetic resonance spectroscopy (NMR). In addition, apoMb forms an intermediate at equilibrium at pH ∼ 4, which is sufficiently stable for it to be structurally characterized by solution methods such as CD, fluorescence and NMR spectroscopies, and the

  11. PREFACE: Eurotherm Seminar 102: Thermal Management of Electronic Systems

    NASA Astrophysics Data System (ADS)

    Punch, J.; Walsh, E.

    2014-07-01

    About EUROTHERM The aim of the EUROTHERM Committee (www.eurothermcommittee.eu) is to promote and foster European cooperation in Thermal Sciences and Heat Transfer by gathering together scientists and engineers working in specialized areas. The Committee consists of members representing and appointed by national bodies in the EU countries. The current President of EUROTHERM is Professor Anton van Steenhoven from the University of Eindhoven (The Netherlands). The Committee organizes and coordinates European scientific events such as the EUROTHERM Seminars (about 4 per year) and the European Thermal Sciences Conference (every 4 years). About EUROTHERM Seminar 102 (www.eurothermseminar102.com) This seminar, part of the long-running series of European seminars on the thermal sciences, took place in June 2014 at the University of Limerick in Limerick, Ireland. The seminar addressed the topic of 'Thermal Management of Electronic Systems', a critical contemporary application area which represents a vibrant challenge for practitioners of the thermal sciences. We convey special thanks to the reviewers who have evaluated these papers. We also thank the scientific committee, consisting of internationally recognized experts. Their role has been to manage the evaluation of abstracts and the papers selection process as co-coordinators for specific topics. This seminar was hosted by the Stokes Institute at the University of Limerick. It could not have been organized without the efficient help of our administrators and technicians for IT support. This volume of Journal of Physics: Conference Series includes 27 articles presented at the seminar. Dr. Jeff Punch, Chair Stokes Institute, University of Limerick, Limerick, Ireland Email: jeff.punch@ul.ie Prof. Edmond Walsh, Co-Chair Associate Professor, Osney Laboratories, Department of Engineering Science, University of Oxford, UK Email: edmond.walsh@bnc.ox.ac.uk

  12. Problem Solving through Paper Folding

    ERIC Educational Resources Information Center

    Wares, Arsalan

    2014-01-01

    The purpose of this article is to describe a couple of challenging mathematical problems that involve paper folding. These problem-solving tasks can be used to foster geometric and algebraic thinking among students. The context of paper folding makes some of the abstract mathematical ideas involved relatively concrete. When implemented…

  13. How do chaperonins fold protein?

    PubMed Central

    Motojima, Fumihiro

    2015-01-01

    Protein folding is a biological process that is essential for the proper functioning of proteins in all living organisms. In cells, many proteins require the assistance of molecular chaperones for their folding. Chaperonins belong to a class of molecular chaperones that have been extensively studied. However, the mechanism by which a chaperonin mediates the folding of proteins is still controversial. Denatured proteins are folded in the closed chaperonin cage, leading to the assumption that denatured proteins are completely encapsulated inside the chaperonin cage. In contrast to the assumption, we recently found that denatured protein interacts with hydrophobic residues at the subunit interfaces of the chaperonin, and partially protrude out of the cage. In this review, we will explain our recent results and introduce our model for the mechanism by which chaperonins accelerate protein folding, in view of recent findings. PMID:27493521

  14. An Instructional Seminar for Online Case-Based Discussions

    PubMed Central

    LeBlanc, Jaclyn M.; Rohdieck, Stephanie V.; Khurma, Anand; Dasta, Joseph F.

    2007-01-01

    Objective To assess a training seminar developed to prepare pharmacy instructors to facilitate online discussions. Design A 2-part seminar was developed to train faculty members and teaching assistants to facilitate online case-based discussions. A preseminar survey instrument was distributed to potential attendees and a postseminar survey instrument was given to those who attended the seminar. Assessment Twenty (91%) instructors completed the preseminar survey instrument. Eleven of these instructors attended at least 1 session of the seminar and indicated that the didactic and/or application portions were either “helpful” or “very helpful.” These faculty members and teaching assistants also completed the postseminar survey instrument and conveyed a significant increase in level of comfort in their ability to facilitate online case-based discussions (p=0.004). The 3 most frequently perceived barriers to online teaching remained consistent despite training or teaching experience. Conclusions After attending a training seminar and/or facilitating an online case discussion, participants' comfort level in their ability to teach online increased. Further study of the impact of faculty development programs on teaching effectiveness and student satisfaction with online pharmacy education is warranted. PMID:17619642

  15. What I Did Last Summer: The Fulbright-Hays Seminars Abroad.

    ERIC Educational Resources Information Center

    Martin, Marlene

    2003-01-01

    Describes the Fulbright-Hays seminar and the author's experience with it. Discusses the application process and experiences with Fulbright seminars in Poland, Hungary, Peru, and Ecuador. Notes how she and her colleagues use Fulbright information in their classrooms. (SG)

  16. Inframammary fold: a histologic reappraisal.

    PubMed

    Muntan, C D; Sundine, M J; Rink, R D; Acland, R D

    2000-02-01

    The inframammary fold is a defining element in the shape and structure of the female breast. It should be preserved whenever possible in ablative procedures and recreated accurately when the breast is reconstructed after mastectomy. To date, no accurate anatomic description of this essential structure exists. Previous studies have suggested that the fold is produced by a supporting ligament running from the dermis in the fold region to a variety of locations on the rib cage. This clinic's experience with mastectomy, augmentation mammaplasty, and breast reconstruction does not support the existence of a ligamentous structure. To define the structure of the inframammary fold, 10 female and 2 male cadavers were studied. The anterior chest wall was removed en bloc and frozen in orthostatic position. Parasagittal sections were made of the inframammary fold with the chest wall intact. After decalcification of the ribs and routine histologic preparation, thin sections were stained with Gomori's trichrome. On light microscopic examination, no demonstrable ligamentous structure of dense regular connective tissue could be identified in the fold region in any of the 12 specimens. Superficial and deep fascial layers were uniformly observed anterior to the pectoralis major and serratus anterior muscles. The superficial fascia was connected to the dermis in the fold region in a variety of configurations. In some cases, the deep fascia fused with the superficial fascia and dermis at the fold level. In other cases, bundles of collagen fibers arising from the superficial fascial layer were found to insert into the dermis at the inframammary fold, slightly inferior to it, or both. These bundles were observed consistently in sections from the sternum to the middle axillary line. They were distinct from Cooper's suspensory ligaments, which are seen more superiorly in the glandular tissue.

  17. The Interactive Seminar: An Educational Approach for Voluntary HIV Testing in a Drug Dependence Treatment Unit.

    ERIC Educational Resources Information Center

    Sedhom, Laila; And Others

    1994-01-01

    A survey of 118 male patients in a drug dependence treatment unit before and after an interactive seminar with a nonjudgmental professional showed that seminar participants, especially intravenous drug users, had higher rates of voluntary HIV testing than nonparticipants. Drug users who completed detoxification and attended the seminar also had…

  18. A Follow-Up Study of the Three-Week Residential Seminar in PPBS.

    ERIC Educational Resources Information Center

    Civil Service Commission, Washington, DC. Bureau of Training.

    The influence of the Three Week Residential Seminar in PPB offered by the Civil Service Commission on the job performance, attitudes, and career development of participants who attended the first 15 seminars was studied. The seminar program was developed to retrain experienced analysts (financial, budget, and management) and PPB output user…

  19. The Impact of First-Year Seminars on College Students' Life-Long Learning Orientations

    ERIC Educational Resources Information Center

    Padgett, Ryan D.; Keup, Jennifer R.; Pascarella, Ernest T.

    2013-01-01

    Using longitudinal data from the Wabash National Study of Liberal Arts Education, this study measured the impact of first-year seminars on college students' life-long learning orientations. The findings suggest that first-year seminars enhance students' life-long learning orientations and that the effect of first-year seminars is mediated through…

  20. Proceedings of the China-Japan-U.S. Seminar on Mathematical Education.

    ERIC Educational Resources Information Center

    Zhang, Dianzhou, Ed.; And Others

    This document contains the proceedings of the China-Japan-U.S. Seminar on Mathematical Education that was held in 1993 in China. The focus of the Seminar was problem solving in mathematics education. The main purposes of the seminar were: to examine the present states of problem solving in school mathematics in China, Japan, and the U.S.; to…

  1. "Freeing Students to Do Their Best": Examining Writing in First-Year Seminars

    ERIC Educational Resources Information Center

    Thaiss, Chris; Moloney, Kara; Chaozon-Bauer, Pearl

    2016-01-01

    First-Year Seminars (FYS) are among the high-impact practices described by AAC&U. We studied the long-standing First-Year Seminar Program at our public research university for the ways in which writing assignments--individualized for each seminar--help faculty and students achieve program objectives in critical and analytical thinking, the…

  2. Why Manufacturers Do--and Do Not--Attend Educational Seminars. SBDC Professional Enrichment.

    ERIC Educational Resources Information Center

    Swanson, David

    Examination of numerous studies of executives of small manufacturing firms in Iowa offered insights on their attitudes and actions regarding educational seminars. Findings showed that 62.7 percent of manufacturers attended at least one seminar in the last year. The term "seminar" had a better customer satisfaction rating than…

  3. An Interdisciplinary Study of the SARS Virus: A One-Semester First-Year Seminar

    ERIC Educational Resources Information Center

    Ealy, Julie; Dorward, Adrienne

    2005-01-01

    The rationale for the first-year seminar is to introduce freshmen to the university. The basic components of a first-year seminar are academic integrity, skill development, a sense of community, active and collaborative learning strategies, and technology. All freshmen must take a first-year seminar that consists primarily of freshmen, although…

  4. Fog spontaneously folds mosquito wings

    NASA Astrophysics Data System (ADS)

    Dickerson, Andrew K.; Liu, Xing; Zhu, Ting; Hu, David L.

    2015-02-01

    The flexibility of insect wings confers aerodynamic benefits, but can also present a hazard if exposed to fog or dew. Fog can cause water to accumulate on wings, bending them into tight taco shapes and rendering them useless for flight. In this combined experimental and theoretical study, we use high-speed video to film the spontaneous folding of isolated mosquito wings due to the evaporation of a water drop. We predict shapes of the deformed wing using two-dimensional elastica theory, considering both surface tension and Laplace pressure. We also recommend fold-resistant geometries for the wings of flapping micro-aerial vehicles. Our work reveals the mechanism of insect wing folding and provides a framework for further study of capillarity-driven folding in both natural and biomimetic systems at small scales.

  5. Folding gravitational-wave interferometers

    NASA Astrophysics Data System (ADS)

    Sanders, J. R.; Ballmer, Stefan W.

    2017-01-01

    The sensitivity of kilometer-scale terrestrial gravitational wave interferometers is limited by mirror coating thermal noise. Alternative interferometer topologies can mitigate the impact of thermal noise on interferometer noise curves. In this work, we explore the impact of introducing a single folding mirror into the arm cavities of dual-recycled Fabry–Perot interferometers. While simple folding alone does not reduce the mirror coating thermal noise, it makes the folding mirror the critical mirror, opening up a variety of design and upgrade options. Improvements to the folding mirror thermal noise through crystalline coatings or cryogenic cooling can increase interferometer range by as much as a factor of two over the Advanced LIGO reference design.

  6. A spiritual health community seminar based on religious commitment research.

    PubMed

    Lottes, Christine R; Engstrom, Del; Engstrom, Lorri F

    2002-12-01

    There is a need for spiritual health seminars at the work site and through hospital and other community venues. This article describes how the authors prepared for and conducted seminars in their community. The research demonstrates that religious commitment may play a beneficial role in an individual's health. Once the authors were armed with this research and a fundamentally sound and practical program, they were able to assist individuals in their community in designing and initiating their own individual spiritual health workouts, which may then influence their physical and mental health. In this way, the authors were able to apply holistic principles of spirit, mind, and body.

  7. Rondeau Seminars amalgamated mid-sagittal (lateral) cephalometric analysis.

    PubMed

    Palencar, Adrian J

    2014-01-01

    The author presents a comprehensive International Association for Orthodontics--Rondeau Seminars Amalgamated Mid-sagittal (Lateral) Cephalometric Analysis. Norms on the Cephalometric Data Sheet are age and gender specific for the Caucasian population and the postings are color coded for visual attraction. If the patient is ofa different ethnic group, the Norms should be adjusted accordingly. This Cephalometric Analysis is comprised often Sections, in alphabetical order and twenty nine Factors. The author expanded Rondeau Seminars Cephalometric Analysis by only six Factors, thus fulfilling the requirement for the case presentation for the Fellow of the IAO and the Diplomate ofthe IBO.

  8. Protein folding by motion planning

    NASA Astrophysics Data System (ADS)

    Thomas, Shawna; Song, Guang; Amato, Nancy M.

    2005-12-01

    We investigate a novel approach for studying protein folding that has evolved from robotics motion planning techniques called probabilistic roadmap methods (PRMs). Our focus is to study issues related to the folding process, such as the formation of secondary and tertiary structures, assuming we know the native fold. A feature of our PRM-based framework is that the large sets of folding pathways in the roadmaps it produces, in just a few hours on a desktop PC, provide global information about the protein's energy landscape. This is an advantage over other simulation methods such as molecular dynamics or Monte Carlo methods which require more computation and produce only a single trajectory in each run. In our initial studies, we obtained encouraging results for several small proteins. In this paper, we investigate more sophisticated techniques for analyzing the folding pathways in our roadmaps. In addition to more formally revalidating our previous results, we present a case study showing that our technique captures known folding differences between the structurally similar proteins G and L. This research was supported in part by NSF CAREER Award CCR-9624315, NSF Grants ACI-9872126, EIA-9975018, EIA-0103742, EIA-9805823, ACR-0113971, CCR-0113974, EIA-9810937, EIA-0079874 and the Texas Higher Education Coordinating Board grant ATP-000512-0261-2001. ST was supported in part by an NSF Graduate Research Fellowship. GS was supported in part by an IBM PhD Fellowship.

  9. LAUC Seminars on Career Development for Academic Librarians.

    ERIC Educational Resources Information Center

    Kleingartner, Archie; And Others

    During 1976-77, the Berkeley Division of the Librarians Association of the University of California sponsored four seminars on career development for academic librarians. The speakers and their topics were: Archie Kleingartner (Vice President for Academic and Staff Personnel Relations, University of California), "The professional in the…

  10. Multiple Assessments of a First-Year Seminar Pilot

    ERIC Educational Resources Information Center

    Barton, Andrew; Donahue, Christiane

    2009-01-01

    First-year seminars have become common at liberal arts and other colleges across the United States. An accumulating body of research appears to demonstrate that this curricular element is associated with increased retention of students and is positively correlated with graduation rates, student adjustment and involvement, student satisfaction,…

  11. Seminar in Language and Language Learning. Final Report.

    ERIC Educational Resources Information Center

    Washington Univ., Seattle.

    Collected here are ten unpublished work papers from a 1962 Seminar in Seattle, held for the purpose of evaluating the interdisciplinary needs of the doctoral candidate who is receiving special training to organize the teaching of foreign languages in schools and universities. Authors are Dwight L. Bolinger (linguistics), John B. Carroll (programed…

  12. Proceedings of the Third EPRI Phased Array Ultrasound Seminar

    SciTech Connect

    2003-12-01

    Phased array technology for ultrasonic examination is providing innovative solutions for nuclear in-service examination applications. EPRI has been a prime mover in the development and deployment of phased array ultrasound applications in the domestic nuclear market over the past decade. As part of this strategic effort, EPRI has hosted a series of seminars on phased array technology and its applications.

  13. Serious Games: A Seminar Map for International Business Schools

    ERIC Educational Resources Information Center

    Witte, Anne E.

    2014-01-01

    One business school addressed the "zeitgeist" of the financial crisis by introducing in its inaugural seminar the cultural and ethical values too often absent from the types of transactions students are trained to manage. Drawing from cross-cultural and communication studies, the author tested "serious games"--cultural…

  14. VOCATIONAL-TECHNICAL EDUCATION LEADERSHIP DEVELOPMENT SEMINAR. FINAL REPORT.

    ERIC Educational Resources Information Center

    Missouri Univ., Columbia. Coll. of Education.

    SIXTY VOCATIONAL EDUCATION LEADERS FROM 18 STATES MET FOR A 2-WEEK SEMINAR IN JULY 1967 TO GAIN--(1) EXPERIENCE IN CONFERENCE LEADING AND OTHER LEADERSHIP TECHNIQUES, (2) AN INSIGHT INTO THE POSSIBILITIES AND RESPONSIBILITIES OF LEADERSHIP IN VOCATIONAL-TECHNICAL EDUCATION, (3) AN UNDERSTANDING OF TRENDS AND FUTURE DEVELOPMENTS, AND (4) AN INSIGHT…

  15. Growing Time. Selected Papers from the Michigan State Leadership Seminars.

    ERIC Educational Resources Information Center

    DeCrow, Roger, Ed.

    Ten essays from the Michigan State Leadership Seminars discuss the social imperatives confronting adult education and what the university can do and ought to be doing about them. The impact of the population explosion, urbanization, automation, the knowledge explosion, and the Bomb make it imperative that new concepts of work and leisure be built…

  16. Summer Pre-College Seminar. Camelot. The Challenge Story.

    ERIC Educational Resources Information Center

    Hayman, Ed

    This paper discusses the 1970 Pre-College Seminar conducted by the University of Michigan Flint College for Flint high school students. A two phase program was designed to acknowledge the differing needs of the participants. The first phase was a six week program for all students without regard to their grade achievement. The second phase was…

  17. Chemical Safety and Scientific Ethics in a Sophomore Chemistry Seminar.

    ERIC Educational Resources Information Center

    Moody, Anne E.; Freeman, R. Griffith

    1999-01-01

    Describes how chemical safety and scientific ethics are incorporated into a sophomore seminar in chemistry. Suggests that students need to recognize potential chemical hazards, choose appropriate methods for protecting themselves, and understand the ethical guidelines that the scientific community needs in order to function. (CCM)

  18. Mexico 1996. Fulbright-Hays Summer Seminar Abroad 1996 (Mexico).

    ERIC Educational Resources Information Center

    Lopez, Salvador

    This paper shares the impressions of a participant from the 1996 Fulbright-Hays Summer Seminars Abroad Program in Mexico. These impressions address several current interest topics about international relations with Mexico including: (1) immigration; (2) politics; (3) education; (4) the economy; (5) the environment; (6) the media; (7) religion; and…

  19. Group Development in a High School Adjustment Seminar.

    ERIC Educational Resources Information Center

    Floyd, Nubra Elaine

    1989-01-01

    Directed seminar concerning academic difficulty for ninth-grade Afro-American students (N=5) to observe group dynamics in relation to Bion's concept of psychodynamic group process and Bennis and Shepard's theory of group development. Observed changes in life of group that suggest phasic development. Noted group resistance to Black female…

  20. Material Feminist Practices in a Body Politics Seminar

    ERIC Educational Resources Information Center

    Stein, Rachel

    2014-01-01

    In this article, Rachel Stein focuses on two course projects in which students apply materialist feminist practices within a capstone women's studies seminar entitled Body Politics. Undertaking these projects, students become more critically aware of gendered materialities that they had previously taken for granted as they deconstruct material…

  1. A Seminar Approach to T.A.G. Education.

    ERIC Educational Resources Information Center

    Hanson, Roger L.

    A former teacher of secondary talented and gifted (T.A.G.) students outlines principles and procedures of a seminar approach in which students assume the role of teachers. Procedures are seen to involve student interviews, student teacher conferences, and opportunities for independent work. Sample forms for the interview and project study aspects…

  2. The Kendall College Human Potential Seminar: Guidelines and Materials.

    ERIC Educational Resources Information Center

    Kleemann, Joseph L.

    The aim of the Kendall College Human Potential Seminar (KCHPS) is to provide a structure within which persons can generate and share extensive positive information about themselves. It also creates greater participant awareness of, and respect for, human potential--their own as well as that of others. This paper consists of guidelines and…

  3. Social and Emotional Learning in a Freshman Seminar

    ERIC Educational Resources Information Center

    Wyatt, Jeannette B.; Bloemker, Geraldine A.

    2013-01-01

    First year college students are challenged both socially and academically in their transition to college life. The literature suggests that social and emotional competence skills can help with this transition. This article describes the course content for a University freshman seminar that teaches skills in social and emotional competence in order…

  4. Incorporating Business Communication in an Integrative Business Seminar.

    ERIC Educational Resources Information Center

    Luse, Donna W.

    1999-01-01

    Describes the Integrative Business Seminar in the College of Business Administration at Northeast Louisiana University in which the principal courses in business communication, management, marketing, and finance as well as a segment in problem solving, are taught as one 15-credit hour block in which subject areas are treated as an integrated…

  5. Inequalities in Educational Development: Papers Presented at an IIEP Seminar.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    Based on the realization that the rapid worldwide growth of educational systems over the last two decades has not produced the expected eradication of social inequality, an international seminar was held for educational policy-makers, planners from developing countries, research workers in the area, and representatives of aid agencies from 33…

  6. Enhancing Leadership Education: Insights from a Seminar Evaluation

    ERIC Educational Resources Information Center

    Lyman, Linda L.; Gardner, Dianne C.

    2008-01-01

    Definitions are central to both the practice and the power of leadership. This deceptively simple supposition was the basis for an elective doctoral leadership seminar at Illinois State University designed and taught by Lyman in Fall 2005, and replicated by Gardner in Spring 2007. The authors featured the same texts and stimulated students'…

  7. Report on Mitchell Senior Seminar 1973-74.

    ERIC Educational Resources Information Center

    Fornander, Garold A.

    Describing and evaluating an experimental program in experiential education conducted during the 1973-74 school year at Mitchell High School in Colorado Springs, Colorado, this paper includes: a discussion of program planning and development; a report on the operation of the Seminar; a discussion of the evaluation process and results; and a…

  8. Seminar On Sanitation for Restaurant Owners and Managers. Unit I.

    ERIC Educational Resources Information Center

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, the conceptual outline is organized to provide four hours of classroom instruction. Two major concepts are emphasized. The first concept, the effect of sanitary practices on the financial profits of food service, focuses on: (1) service and quality to…

  9. Planning, Practice, and Assessment in the Seminar Classroom

    ERIC Educational Resources Information Center

    Billings, Laura; Roberts, Terry

    2006-01-01

    The Paideia Seminar was first defined as part of philosopher Mortimer Adler's Paideia Program in "The Paideia Proposal" (1982) and two other books that followed ("Paideia Problems and Possibilities," 1983, and "The Paideia Program," 1984) shortly thereafter. From the beginning, this teaching and learning strategy was intended to be used as part of…

  10. ANTA Training Update Seminar Proceedings (Brisbane, Australia, July 10, 1997).

    ERIC Educational Resources Information Center

    Australian National Training Authority, Brisbane.

    This document contains the papers and questions submitted at the Australian National Training Authority's 1997 training update seminar, which focused on vocational education and training in schools and in technical and further education (TAFE) institutions across Australia. The following papers are included: "Welcome and Comments"…

  11. GCLR Web Seminars as a Venue for Transformative Educational Policy

    ERIC Educational Resources Information Center

    Angay-Crowder, Tuba; Albers, Peggy; Pace, Christi L.; Jung, Jin Kyeong Frances; Hwang, Ju A.; Pang, Myoung Eun

    2014-01-01

    This article features a discussion about the significance of global perspectives in shaping critical literacy through a web seminar project, Global Conversations in Literacy Research (GCLR). Ubiquitous media and worldwide communication via Internet change the perceptions about literacy and language, urging critical discussions around literacy…

  12. Arts Education Beyond the Classroom. ACA Arts Research Seminar Series.

    ERIC Educational Resources Information Center

    Balfe, Judith H., Ed.; Heine, Joni Cherbo, Ed.

    The 13 seminar papers presented in this collection discuss various avenues used for educating adults in the arts in order to enrich existing arts audiences and to educate the widest possible adult population in the practice and history of art and aesthetics. These efforts will ensure that the quality and quantity of arts participation and support…

  13. Teaching Critical Thinking: Using Seminars for 21st Century Literacy

    ERIC Educational Resources Information Center

    Roberts, Terry; Billings, Laura

    2012-01-01

    Help students meet today's literacy demands with this new book from Terry Roberts and Laura Billings. The authors show how a seminar approach can lead students deeper into a text and improve their speaking, listening, and writing skills, as recommended by the Common Core State Standards. Roberts and Billings provide easy-to-follow information on…

  14. 1982 UCC-ND/GAT environmental protection seminar: proceedings

    SciTech Connect

    Not Available

    1983-04-01

    This environmental protection seminar was divided into seven sessions: (1) general environmental protection, (2) air and water pollution control, (3) spill control and countermeasures, (4) toxic materials control, (5) hazardous materials control, (6) environmental protection projects, and (7) cost benefit analysis. Separate abstracts have been prepared for the 41 papers presented therein. (ACR)

  15. A Multidisciplinary First-Year Seminar about Tuberculosis.

    ERIC Educational Resources Information Center

    Fluck, Richard A.

    2001-01-01

    Describes a writing intensive seminar for college freshman. Includes goals, reading assignments, writing assignments, and group projects. Provides web-based resources on tuberculosis along with an evaluation sheet for web site reviews. Concludes that students exhibited great interest in the topic and course feedback was positive. (DLH)

  16. Seminar: Legal Perspectives of Nursing Practice. Nursing 89.

    ERIC Educational Resources Information Center

    Willis, Odette P.

    This course outline provides information to be used by students in conjunction with Nursing 89, a seminar on the legal aspects of nursing to be offered starting in Spring 1982 at Diablo University (California). General information is provided first, including a class calendar, a statement defining the purpose of the course, an outline of…

  17. Ice Cream Seminars for Graduate Students: Imparting Chemical Information Literacy

    ERIC Educational Resources Information Center

    Garritano, Jeremy R.

    2007-01-01

    This article provides information on a chemical information literacy program designed primarily for new graduate students. The full implementation of this program is discussed, including defining its purpose, topics covered, content presented, methods of marketing, and evaluation. The result is a series of voluntary seminars given biweekly…

  18. Proceedings document for wood-heating seminar 6

    SciTech Connect

    Not Available

    1980-01-01

    Papers presented at the seminar are included in this volume. The topics covered are broad and include such areas as advertising and selling of wood burning appliances, creosote problems, forest management, energy efficiency, safety, and cleaning of wood burning stoves and chimneys. Separate abstracts of individual items within scope have been prepared for inclusion in the Energy Data Base. (DMC)

  19. Maximizing Educator Enhancement: Aligned Seminar and Online Professional Development

    ERIC Educational Resources Information Center

    Shaha, Steven; Glassett, Kelly; Copas, Aimee; Huddleston, T. Lisa

    2016-01-01

    Professional development and learning has a long history in seminar-like models, as well as in the more educator-personal delivery approaches. The question is whether an intentionally coordinated, integrated combination of the two PDL approaches will have best impacts for educators as quantified in improved student performance. Contrasts between…

  20. Hamlet on the Macintosh: An Experimental Seminar That Worked.

    ERIC Educational Resources Information Center

    Strange, William C.

    1987-01-01

    Describes experimental college Shakespeare seminar that used Macintosh computers and software called ELIZA and ADVENTURE to develop character dialogs and adventure games based on Hamlet's characters and plots. Programming languages are examined, particularly their relationship to metaphor, and the use of computers in humanities is discussed. (LRW)

  1. Toward the Unnamed: Creative Strategies in a Fine Arts Seminar.

    ERIC Educational Resources Information Center

    Careau, Steven

    2001-01-01

    Describes an honors-level fine arts seminar that culminates in the creation of an 'unnamed' object. Stresses direct manipulation of materials leading to works free of conceptual pre-determination. Argues that naming follows creation; leaving a work unnamed allows artists to experience the dynamic of creation. (NB)

  2. Reflections of Students in Their Use of Asynchronous Online Seminars

    ERIC Educational Resources Information Center

    Groves, Mark; O'Donoghue, John

    2009-01-01

    This paper reports on research that has been carried out into the use, process, and effectiveness of an asynchronous online seminar within an undergraduate sports studies degree programme. Contemporary sources are used to justify the use of technology supported learning (TSL) in higher education and to inform a reflective and critical account of…

  3. Results from the Independent Evaluation of the Seminars on Science

    ERIC Educational Resources Information Center

    Stokes, Laura; St. John, Mark; Hirabayashi, Judy; Smith, Anita

    2007-01-01

    In 1998, the American Museum of Natural History (AMNH) launched an ambitious effort to create on-line science courses for K-12 educators that would immerse them in exciting science topics and give them access to the Museum's scientific resources (scientists, research, expeditions, collections, and exhibitions). This project, called Seminars on…

  4. The Institute and the Environment: An Awareness Seminar.

    ERIC Educational Resources Information Center

    Freeh, LaVern A.

    Focusing on the Institute's role in environmental affairs, the challenges facing the Institute, and the importance of its current activities and programs as they relate to the environment, an Environmental Issues Seminar was conducted by the Institute of Agriculture, University of Minnesota on September 16-17, 1971. This publication contains the…

  5. LEADERSHIP DEVELOPMENT SEMINAR, VOCATIONAL-TECHNICAL EDUCATION. FINAL REPORT.

    ERIC Educational Resources Information Center

    NELSON, RICHARD S.; SMITH, CLODUS R.

    THIRTY-SEVEN VOCATIONAL EDUCATORS, EIGHT STAFF MEMBERS, AND 29 RESOURCE PERSONS PARTICIPATED IN A SEMINAR DESIGNED TO DEVELOP UNDERSTANDINGS, ABILITIES, AND ATTITUDES FOR MORE EFFECTIVE LEADERSHIP BY THE PROFESSIONAL PERSONNEL IN 11 WESTERN STATES AND GUAM. SUMMARIES OF THE FOLLOWING PRESENTATIONS ARE INCLUDED--(1) "HOW TO COMMUNICATE--ORAL…

  6. Fulbright-Hays Seminars Abroad Program: Malaysia 1995. Participants' Reports.

    ERIC Educational Resources Information Center

    Malaysian-American Commission on Educational Exchange, Kuala Lumpur.

    These reports and lesson plans were developed by teachers and coordinators who traveled to Malaysia during the summer of 1995 as part of the U.S. Department of Education's Fulbright-Hays Seminars Abroad Program. Sections of the report include: (1) "Gender and Economics: Malaysia" (Mary C. Furlong); (2) "Malaysia: An Integrated,…

  7. Structuring an Undergraduate Mathematics Seminar Dealing with Options and Hedging

    ERIC Educational Resources Information Center

    Prevot, K. J.

    2006-01-01

    Offering mathematics majors the opportunity to engage in current, real-world applications can be an important enhancement to their undergraduate course curriculum. Instead of focusing on the traditional topic areas in pure and/or applied mathematics, one may structure a seminar course for senior mathematics majors by concentrating on a specific…

  8. Seminar on Sanitation for Restaurant Owners and Managers. Unit II.

    ERIC Educational Resources Information Center

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, unit two of the curriculum guide is organized to provide four hours of classroom instruction. Four major concepts are emphasized. The first concept, providing sanitary conditions in food service establishments, discusses safe use and storage of cleaning…

  9. A Successful Senior Seminar: Unsolved Problems in Number Theory

    ERIC Educational Resources Information Center

    Styer, Robert

    2014-01-01

    The "Unsolved Problems in Number Theory" book by Richard Guy provides nice problems suitable for a typical math major. We give examples of problems that have worked well in our senior seminar course and some nice results that senior math majors can obtain.

  10. Communicating about Sexuality: An Interdisciplinary Undergraduate Honors Seminar.

    ERIC Educational Resources Information Center

    Rozema, Hazel J.

    A course in the honors program (a sophomore level social science seminar) at Millikin University offers an interdisciplinary approach to communication and sexuality, functions as a course in the Gender Studies Minor curriculum, and provides a needed source of sex education for the campus. The purpose of the course is to facilitate communication…

  11. Some Mathematical Elements in a First-Year Seminar Course

    ERIC Educational Resources Information Center

    Pinter, Mike

    2007-01-01

    A first-year seminar general education course provides a good opportunity to search for mathematical topics associated with the popular culture represented in the course's required films and readings. We discuss mathematical connections to several books, including "Life of Pi" and "The Curious Incident of the Dog in the Night-Time," and to the…

  12. Satellite Seminars: An Alternative Method for Extension Educators?

    ERIC Educational Resources Information Center

    Kiernan, N. E.; And Others

    1995-01-01

    Satellite seminars in grain and forage crop production and pest management were conducted for a large, geographically dispersed audience of farmers and agribusiness persons to test the feasibility of an alternative delivery method in extension. Results of a formative evaluation revealed it is feasible to create an alternative model. (LZ)

  13. Papers of the Rural Community Development Seminar: Focus on Iowa.

    ERIC Educational Resources Information Center

    Iowa State Univ. of Science and Technology, Ames. Center for Agricultural and Rural Development.

    A seminar was conducted which provides a foundation upon which research, education, and action programs might be based as a state university brings its programs to focus more fully on the economic and social problems of rural areas. Papers presented covered the following subjects: objectives of community development, trends related to rural areas,…

  14. Turbulent phenomena in protein folding.

    PubMed

    Kalgin, Igor V; Chekmarev, Sergei F

    2011-01-01

    Protein folding and hydrodynamic turbulence are two long-standing challenges, in molecular biophysics and fluid dynamics, respectively. The theories of these phenomena have been developed independently and used different formalisms. Here we show that the protein folding flows can be surprisingly similar to turbulent fluid flows. Studying a benchmark model protein (an SH3 domain), we have found that the flows for the slow folding trajectories of the protein, in which a partly formed N- and C-terminal β sheet hinders the RT loop from attaching to the protein core, have many properties of turbulent flows of a fluid. The flows are analyzed in a three-dimensional (3D) space of collective variables, which are the numbers of native contacts between the terminal β strands, between the RT loop and the protein core, and the rest of the native contacts. We have found that the flows have fractal nature and are filled with 3D eddies; the latter contain strange attractors, at which the tracer flow paths behave as saddle trajectories. Two regions of the space increment have been observed, in which the flux variations are self-similar with the scaling exponent h=1/3, in surprising agreement with the Kolmogorov inertial range theory of turbulence. In one region, the cascade of protein rearrangements is directed from larger to smaller scales (net folding), and in the other, it is oppositely directed (net unfolding). Folding flows for the fast trajectories are essentially "laminar" and do not have the property of self-similarity. Based on the results of our study, we infer, and support this inference by simulations, that the origin of the similarity between the protein folding and turbulent motion of a fluid is in a cascade mechanism of structural transformations in the systems that underlies these phenomena.

  15. NoFold: RNA structure clustering without folding or alignment.

    PubMed

    Middleton, Sarah A; Kim, Junhyong

    2014-11-01

    Structures that recur across multiple different transcripts, called structure motifs, often perform a similar function-for example, recruiting a specific RNA-binding protein that then regulates translation, splicing, or subcellular localization. Identifying common motifs between coregulated transcripts may therefore yield significant insight into their binding partners and mechanism of regulation. However, as most methods for clustering structures are based on folding individual sequences or doing many pairwise alignments, this results in a tradeoff between speed and accuracy that can be problematic for large-scale data sets. Here we describe a novel method for comparing and characterizing RNA secondary structures that does not require folding or pairwise alignment of the input sequences. Our method uses the idea of constructing a distance function between two objects by their respective distances to a collection of empirical examples or models, which in our case consists of 1973 Rfam family covariance models. Using this as a basis for measuring structural similarity, we developed a clustering pipeline called NoFold to automatically identify and annotate structure motifs within large sequence data sets. We demonstrate that NoFold can simultaneously identify multiple structure motifs with an average sensitivity of 0.80 and precision of 0.98 and generally exceeds the performance of existing methods. We also perform a cross-validation analysis of the entire set of Rfam families, achieving an average sensitivity of 0.57. We apply NoFold to identify motifs enriched in dendritically localized transcripts and report 213 enriched motifs, including both known and novel structures.

  16. NoFold: RNA structure clustering without folding or alignment

    PubMed Central

    Middleton, Sarah A.

    2014-01-01

    Structures that recur across multiple different transcripts, called structure motifs, often perform a similar function—for example, recruiting a specific RNA-binding protein that then regulates translation, splicing, or subcellular localization. Identifying common motifs between coregulated transcripts may therefore yield significant insight into their binding partners and mechanism of regulation. However, as most methods for clustering structures are based on folding individual sequences or doing many pairwise alignments, this results in a tradeoff between speed and accuracy that can be problematic for large-scale data sets. Here we describe a novel method for comparing and characterizing RNA secondary structures that does not require folding or pairwise alignment of the input sequences. Our method uses the idea of constructing a distance function between two objects by their respective distances to a collection of empirical examples or models, which in our case consists of 1973 Rfam family covariance models. Using this as a basis for measuring structural similarity, we developed a clustering pipeline called NoFold to automatically identify and annotate structure motifs within large sequence data sets. We demonstrate that NoFold can simultaneously identify multiple structure motifs with an average sensitivity of 0.80 and precision of 0.98 and generally exceeds the performance of existing methods. We also perform a cross-validation analysis of the entire set of Rfam families, achieving an average sensitivity of 0.57. We apply NoFold to identify motifs enriched in dendritically localized transcripts and report 213 enriched motifs, including both known and novel structures. PMID:25234928

  17. Folded orthogonal frequency division multiplexing.

    PubMed

    Corcoran, Bill; Zhu, Chen; Song, Binhuang; Lowery, Arthur J

    2016-12-26

    We propose and demonstrate a new sub-carrier multiplexing scheme, utilizing orthogonal, periodic-sinc-shaped sub-carrier spectra. This 'folded' OFDM allows for multi-carrier bands to be generated with the precise, rectangular frequency definition of Nyquist WDM. We show that this scheme can be implemented with 10 GHz sub-bands, showing a 0.5-dB implementation penalty and successful transmission over 4160-km. We further investigate 40-GHz bands in an add/drop multiplexing scenario on a 50-GHz WDM grid, and show that folded OFDM can provided advantages over conventional OFDM in bandwidth-limited systems.

  18. Mesoscale Modeling of Chromatin Folding

    NASA Astrophysics Data System (ADS)

    Schlick, Tamar

    2009-03-01

    Eukaryotic chromatin is the fundamental protein/nucleic acid unit that stores the genetic material. Understanding how chromatin fibers fold and unfold in physiological conditions is important for interpreting fundamental biological processes like DNA replication and transcription regulation. Using a mesoscopic model of oligonucleosome chains and tailored sampling protocols, we elucidate the energetics of oligonucleosome folding/unfolding and the role of each histone tail, linker histones, and divalent ions in regulating chromatin structure. The resulting compact topologies reconcile features of the zigzag model with straight linker DNAs with the solenoid model with bent linker DNAs for optimal fiber organization and reveal dynamic and energetic aspects involved.

  19. [Saturday Seminars Coordinator's Report.] Seminars for Interested Students, Experimental Project, Department of Education, Planning and Research, June 15, 1973.

    ERIC Educational Resources Information Center

    Fillion, Origene

    Seminars were developed to give francophone students in rural areas intellectual stimulation and experience outside their normal study programs. The aim was to develop French education and to promote French culture for these secondary students. Subject areas were psychology, sociology, and comparative religion. Sixty-one students in grades 10, 11,…

  20. Universities and Education in the Post-Recession Economy: Report of a Seminar Organised by Universities UK. Seminar Report

    ERIC Educational Resources Information Center

    Ryan, Conor

    2010-01-01

    Universities UK organised a seminar in Brighton in April 2010, bringing together vice-chancellors, researchers and policymakers to take a close look at the implications of the global and national economic crisis for both the UK economy and higher education. It also examined the changing nature of student demand in a post-recession economy. This…

  1. Protein folding in the cell

    NASA Astrophysics Data System (ADS)

    Gething, Mary-Jane; Sambrook, Joseph

    1992-01-01

    In the cell, as in vitro, the final conformation of a protein is determined by its amino-acid sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the absence of other macromolecular cellular components, folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.

  2. Use of Protein Folding Reagents.

    PubMed

    2016-04-01

    The reagents and methods for purification and use of the most commonly used denaturants, guanidine hydrochloride (guanidine-HCl) and urea, are described. Other protein denaturants and reagents used to fold proteins are briefly mentioned. Sulfhydryl reagents (reducing agents) and "oxido-shuffling" (or oxidative regeneration) systems are also described.

  3. Privacy Rights in the 21st Century. Seminar Outlines [of the] Education Law Association Winter Seminar (Lake Tahoe, Nevada, March 21-24, 2002).

    ERIC Educational Resources Information Center

    Education Law Association, Dayton, OH.

    This collection of eight seminar outlines focuses on current privacy-rights issues in the arena of education. Seminar outlines include: (1) "The Transparency of Public School Employees' Professional and Personal Lives in the 21st Century: A Canadian Perspective," by Sam Carmen and Val Riewe; (2) "Common Law Privacy in Educational Settings," by…

  4. The 1977 Seminar on Education Finance: Problems and Prospects in Education Finance. Proceedings of a Seminar (Ottawa, Ontario, April 4-5, 1977).

    ERIC Educational Resources Information Center

    Canadian Teachers' Federation, Ottawa (Ontario).

    The theme of this seminar was the exploration of techniques and strategies for improving the funding of elementary and secondary education. The proceedings of the seminar included welcoming remarks by Michael Heron followed by the presentation "Problems and Prospects in Education Finance: Who Is Getting All the Money?" by Dr. Wilfred…

  5. Quantitative Morphology of Epithelial Folds

    PubMed Central

    Štorgel, Nick; Krajnc, Matej; Mrak, Polona; Štrus, Jasna; Ziherl, Primož

    2016-01-01

    The shape of spatially modulated epithelial morphologies such as villi and crypts is usually associated with the epithelium-stroma area mismatch leading to buckling. We propose an alternative mechanical model based on intraepithelial stresses generated by differential tensions of apical, lateral, and basal sides of cells as well as on the elasticity of the basement membrane. We use it to theoretically study longitudinal folds in simple epithelia and we identify four types of corrugated morphologies: compact, invaginated, evaginated, and wavy. The obtained tissue contours and thickness profiles are compared to epithelial folds observed in invertebrates and vertebrates, and for most samples, the agreement is within the estimated experimental error. Our model establishes the groove-crest modulation of tissue thickness as a morphometric parameter that can, together with the curvature profile, be used to estimate the relative differential apicobasal tension in the epithelium. PMID:26745429

  6. Folded supersymmetry with a twist

    DOE PAGES

    Cohen, Timothy; Craig, Nathaniel; Lou, Hou Keong; ...

    2016-03-30

    Folded supersymmetry (f-SUSY) stabilizes the weak scale against radiative corrections from the top sector via scalar partners whose gauge quantum numbers differ from their Standard Model counterparts. This non-trivial pairing of states can be realized in extra-dimensional theories with appropriate supersymmetry-breaking boundary conditions. We present a class of calculable f-SUSY models that are parametrized by a non-trivial twist in 5D boundary conditions and can accommodate the observed Higgs mass and couplings. Although the distinctive phenomenology associated with the novel folded states should provide strong evidence for this mechanism, the most stringent constraints are currently placed by conventional supersymmetry searches. Asmore » a result, these models remain minimally fine-tuned in light of LHC8 data and provide a range of both standard and exotic signatures accessible at LHC13.« less

  7. Folded supersymmetry with a twist

    SciTech Connect

    Cohen, Timothy; Craig, Nathaniel; Lou, Hou Keong; Pinner, David

    2016-03-30

    Folded supersymmetry (f-SUSY) stabilizes the weak scale against radiative corrections from the top sector via scalar partners whose gauge quantum numbers differ from their Standard Model counterparts. This non-trivial pairing of states can be realized in extra-dimensional theories with appropriate supersymmetry-breaking boundary conditions. We present a class of calculable f-SUSY models that are parametrized by a non-trivial twist in 5D boundary conditions and can accommodate the observed Higgs mass and couplings. Although the distinctive phenomenology associated with the novel folded states should provide strong evidence for this mechanism, the most stringent constraints are currently placed by conventional supersymmetry searches. As a result, these models remain minimally fine-tuned in light of LHC8 data and provide a range of both standard and exotic signatures accessible at LHC13.

  8. The SUPERCOMET 2 Project: Teacher Seminar and Teacher Guide

    NASA Astrophysics Data System (ADS)

    Engstrom, V.; Ireson, G.; Latal, H.; Mathelitsch, L.; Michelini, M.; Peeters, W.; Rath, G.

    2008-05-01

    The Leonardo da Vinci pilot projects SUPERCOMET (2001-2004) and SUPERCOMET 2 (2004-2007) developed and tested teacher training materials for active, minds-on learning of electromagnetism and superconductivity at the level of upper secondary school. New multimedia materials for the pupils supported the teacher materials, including a teacher seminar in 4 half-day modules detailing the scientific contents, teaching methods, using ICT in physics teaching and learning, online collaboration and further resources for exploring the selected topics. The aim of these projects were to improve the quality of physics teaching on a European level, involving a combined total of 45 partners in 16 countries, and conducting trials at 67 schools with approx. 230 teachers, 280 trainee teachers and 2200 pupils. New follow-up projects develop hands-on materials for carrying out the activities described in the teacher guide and seminars and additional teacher materials involving modelling, simulations and data logging.

  9. NCI Alliance for Nanotechnology in Cancer - Tutorials and Seminar Series

    Cancer.gov

    View details about tutorials and seminars hosted by Alliance members and members of the cancer research community. These events provide a forum for sharing innovative perspectives on research and development efforts in the field of nanotechnology and their application to cancer diagnosis, treatment, and prevention. Also visit the Event Listing section to find scientific meetings and events where NCI Alliance for Nanotechnology in Cancer leaders and members are participating.

  10. The Effectiveness of Air Force Alcohol Education Seminars.

    DTIC Science & Technology

    1981-09-01

    for the Airman Seminar apply to some extent, more emphasis is placed on the role played by super- visors in the identification process. In fact, the... Behavorial Measures of Responsible Alcohol Use ............................ 107 D.2. Attitudinal Measures of Responsible Alcohol Use...eighth graders were somewhat more positive . At the 6-month follow-up, one experimental group reported a significant decrease in average daily alcohol

  11. Ventricular-Fold Dynamics in Human Phonation

    ERIC Educational Resources Information Center

    Bailly, Lucie; Bernardoni, Nathalie Henrich; Müller, Frank; Rohlfs, Anna-Katharina; Hess, Markus

    2014-01-01

    Purpose: In this study, the authors aimed (a) to provide a classification of the ventricular-fold dynamics during voicing, (b) to study the aerodynamic impact of these motions on vocal-fold vibrations, and (c) to assess whether ventricular-fold oscillations could be sustained by aerodynamic coupling with the vocal folds. Method: A 72-sample…

  12. Seminar 2.0: Learning With Skype and Video Podcasts

    NASA Astrophysics Data System (ADS)

    Wessel, Paul; Anderson, Tiffany; Austin, Regan; Benediktsdottir, Asdis; Chandler, Michael T.; Conley, Michaela M.; Kim, Seung-Sep; Michaud, Robert L.; Rumpf, M. Elise; Sleeper, Jonathan D.; Weiss, Jonathan R.

    2009-04-01

    Graduate seminars typically involve reviewing key papers, ranging from seminal contributions by pioneers to the latest cutting-edge results published in journals such as Nature, Science, and Geophysical Research Letters. Ideally, guest lecturers are invited to add specific expertise and stimulate discussions. However, the increasing costs for travel make this an expensive proposition. Recent improvements in free videoconferencing over the Internet make it possible to invite distant experts to participate in seminars without involving expensive and time-consuming travel. Tools to record video conferences allow anyone to combine narrations with slide presentations and prepare merged video files for distribution over the Internet (i.e., podcasts). This brief report discusses such an experiment in a graduate seminar on advanced plate tectonics in the Department of Geology and Geophysics at University of Hawai`i at Manoa's (UHM) School of Ocean and Earth Science and Technology (SOEST). The podcasts are freely available from iTunes (UHM; SOEST; Public Course Lectures) and from http://www.soest.hawaii.edu/pwessel/podcasts.

  13. A High School Project Seminar on Sea Level Rise

    NASA Astrophysics Data System (ADS)

    Seitz, M.; Bosch, W.

    2012-04-01

    In Bavaria the curriculum of the upper grade of high school includes a so called project seminar, running over one and a half year. The aims of the seminar are to let the pupils learn to work on a specific topic, to organize themselves in a team, to improve their soft skills and become familiar with the working life. The topic of the project seminar, jointly organized by the Bertold-Brecht-Gymnasium in Munich and the Deutsche Geodätische Forschungsinstitut (DGFI) was on the "Global sea level rise". A team of 13 pupils computed the mean sea level rise by using on the one hand altimetry data of TOPEX, Jason-1 and Jason2 and on the other hand data of globally distributed tide gauges, corrected for vertical crustal movements derived from GPS products. The results of the two independent approaches were compared with each other and discussed considering also statements and discussions found in press, TV, and the web. Finally, a presentation was prepared and presented at school.

  14. Folded MEMS approach to NMRG

    NASA Astrophysics Data System (ADS)

    Gundeti, Venu Madhav

    Atomic gyroscopes have a potential for good performance advantages and several attempts are being made to miniaturize them. This thesis describes the efforts made in implementing a Folded MEMS based NMRG. The micro implementations of all the essential components for NMRG (Nuclear Magnetic Resonance Gyroscope) are described in detail in regards to their design, fabrication, and characterization. A set of micro-scale Helmholtz coils are described and the homogeneity of the generated magnetic field is analyzed for different designs of heaters. The dielectric mirrors and metallic mirrors are compared in terms of reflectivity and polarization change up on reflection. A pyramid shaped folded backbone structure is designed, fabricated, and assembled along with all the required components. A novel double-folded structure 1/4th the size of original version is fabricated and assembled. Design and modeling details of a 5 layered shield with shielding factor > 106 and total volume of around 90 cc are also presented. A table top setup for characterization of atomic vapor cell is described in detail. A micro vapor cell based Rb magnetometer with a sensitivity of 108 pT/√Hz is demonstrated. The challenges due to DC heating are addressed and mitigated using an AC heater. Several experiments related to measuring the relaxation time of Xe are provided along with results. For Xe131, relaxation times of T1 = 23.78 sec, T2 = 18.06 sec and for Xe129, T1 = 21.65 sec and T2 = 20.45 sec are reported.

  15. Chaperonin-mediated Protein Folding

    PubMed Central

    Horwich, Arthur L.

    2013-01-01

    We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments. PMID:23803606

  16. Does An Education Seminar Intervention Improve the Parents’ Knowledge on Vaccination? Evidence from Yiwu, East China

    PubMed Central

    Hu, Yu

    2015-01-01

    Background: caregivers’ knowledge on vaccination is an important impact factor for their children’s vaccination status. The aims of this study were to evaluate the caregivers’ knowledge of vaccination, and to assess effectiveness of a health education seminar for improving caregivers’ knowledge on immunization. Methods: pre- and post-assessment design was adopted for a single group to evaluate the effectiveness of the health education seminar on vaccination. The seminar consisted of a lecture using simple understandable language. Improvements in total knowledge score before and after the seminar were assessed using a validated questionnaire that included ten questions. Description analysis and non-parametric tests were applied to evaluate and compare the vaccination knowledge level before and after the seminar. Results: 378 caregivers participated in this study. The majority were mothers. Of the ten questions, the correct response rates had significantly increased for nine questions after the education seminar. The mean total score of the assessment before the seminar was 5.2 ± 1.2 while that was 8.4 ± 0.9 for the assessment after the seminar, with a significant increase of 3.18 points. Conclusion: a short education seminar designed for caregivers had a remarkable effect on their vaccination knowledge. Health education on vaccination targeting migrant caregivers, caregivers with lower education level or household income, and employed caregivers are needed in future. PMID:25811770

  17. Improving protein fold recognition by random forest

    PubMed Central

    2014-01-01

    Background Recognizing the correct structural fold among known template protein structures for a target protein (i.e. fold recognition) is essential for template-based protein structure modeling. Since the fold recognition problem can be defined as a binary classification problem of predicting whether or not the unknown fold of a target protein is similar to an already known template protein structure in a library, machine learning methods have been effectively applied to tackle this problem. In our work, we developed RF-Fold that uses random forest - one of the most powerful and scalable machine learning classification methods - to recognize protein folds. Results RF-Fold consists of hundreds of decision trees that can be trained efficiently on very large datasets to make accurate predictions on a highly imbalanced dataset. We evaluated RF-Fold on the standard Lindahl's benchmark dataset comprised of 976 × 975 target-template protein pairs through cross-validation. Compared with 17 different fold recognition methods, the performance of RF-Fold is generally comparable to the best performance in fold recognition of different difficulty ranging from the easiest family level, the medium-hard superfamily level, and to the hardest fold level. Based on the top-one template protein ranked by RF-Fold, the correct recognition rate is 84.5%, 63.4%, and 40.8% at family, superfamily, and fold levels, respectively. Based on the top-five template protein folds ranked by RF-Fold, the correct recognition rate increases to 91.5%, 79.3% and 58.3% at family, superfamily, and fold levels. Conclusions The good performance achieved by the RF-Fold demonstrates the random forest's effectiveness for protein fold recognition. PMID:25350499

  18. Kinematics and thermodynamics of a folding heteropolymer.

    PubMed Central

    Fukugita, M; Lancaster, D; Mitchard, M G

    1993-01-01

    In order to elucidate the folding dynamics of protein, we have carried out numerical simulations of a heteropolymer model of self-interacting random chains. We find that folding propensity depends strongly on sequence and that both folding and nonfolding sequences exist. Furthermore we show that folding is a two-step process: the transition from coil state to unique folded state takes place through a globule phase. In addition to the continuous coil-globule transition, there exists an abrupt transition that separates the unique folded state from the globule state and ensures the stability of the native state. PMID:8327518

  19. Detachments in Shale: Controlling Characteristics on Fold-Thrust Belt Style

    NASA Astrophysics Data System (ADS)

    Hansberry, Rowan; King, Ros; Collins, Alan; Morley, Chris

    2013-04-01

    (e.g. Platt, 1986; Bilotti and Shaw, 2005; Morley, 2007). Therefore, through a mixture of field observations, sample analysis and theoretical analysis it will be possible to determine a full range of shale detachment parameters and their impact on the structural style of fold-thrust belts across a variety of settings. Recent work in Muak Lek, central Thailand has focused on a structural investigation of fold-thrust belt deformation of a passive margin sequence as a result of continent-continent collision during the Triassic Indosinian Orogeny. Exceptional outcropping of the detachment lithology is accessible in the Siam City Cement quarry allowing construction of sections detailing the deformational style across the detachment itself. The detachment forms complex, 3-dimensional duplex-like structures creating egg-carton geometries enveloping foliation surfaces in the zones of most intense strain. Up section strain decreases to discrete thrust imbricates of decametre scale. Samples of limestone and secondary calcite were collected through the sections for oxygen stable isotopes analysis which show a distinct pattern of isotopic fractionation across the main thrust and into the detachment. Results from this study give insights into the nature of shale detachments and the control on fold-thrust belt development.

  20. Geometry of Miura-folded metamaterials

    PubMed Central

    Schenk, Mark; Guest, Simon D.

    2013-01-01

    This paper describes two folded metamaterials based on the Miura-ori fold pattern. The structural mechanics of these metamaterials are dominated by the kinematics of the folding, which only depends on the geometry and therefore is scale-independent. First, a folded shell structure is introduced, where the fold pattern provides a negative Poisson’s ratio for in-plane deformations and a positive Poisson’s ratio for out-of-plane bending. Second, a cellular metamaterial is described based on a stacking of individual folded layers, where the folding kinematics are compatible between layers. Additional freedom in the design of the metamaterial can be achieved by varying the fold pattern within each layer. PMID:23401549

  1. Folding tools for flat conductor cable harnesses

    NASA Technical Reports Server (NTRS)

    Loggins, R.

    1971-01-01

    Vise grip pliers have detachable metal gripping plates which are changed to accommodate cables from 1 to 3 in. wide and to form any desired fold angle. A second tool squeezes cable along crease to complete the fold.

  2. Commentary: Margaret Mead, the Salzburg Seminar, and a Historical Evaluation Report.

    ERIC Educational Resources Information Center

    Greene, Jennifer C.

    2003-01-01

    Discusses Margaret Mead's evaluation of the first Salzburg Seminar (1947), a forum for international exchange of intellectual ideas and cultural customs. Concludes that Mead's evaluation was highly successful in that it created an evocative representation of the seminar that told readers what it was like for its participants. (SLD)

  3. A May American Economic Review Papers Seminar and an Analytic Project for Advanced Undergraduates

    ERIC Educational Resources Information Center

    Elliott, Catherine S.

    2004-01-01

    The author describes two learning activities for teaching economics at the advanced undergraduate level: a May American Economic Review (AER) papers seminar and an analytic project. Both activities help students learn to "do economics." The May AER papers seminar promotes in-depth synthesis and interpretation on the basis of printed session papers…

  4. Economic Evaluation of Building Design, Construction, Operation and Maintenance. Seminar Workbook.

    ERIC Educational Resources Information Center

    Ruegg, Rosalie T.

    This workbook has been prepared for participants in the seminar, "Economic Evaluation of Building Design, Construction, Operation and Maintenance." It has two main functions: (1) to provide basic resource materials, references, and introductions to methods employed in the seminar; and (2) to provide instructional problems for solution by…

  5. Massachusetts Higher Education in the Eighties: Proposals for Development. A White Paper. The Alden Seminars.

    ERIC Educational Resources Information Center

    Pile, Wilson, Ed.

    Two position papers on higher education in Massachusetts in the 1980s, which were prepared by the Alden Seminar for Higher Education, are presented. In addition, an overview of the Alden Seminar meeting (Boston, Massachusetts, October 1983), which examined proposals for a Higher Education Development Corporation, is included. In "Adjusting to…

  6. Use of Wikiversity and Role Play to Increase Student Engagement during Student-Led Physiology Seminars

    ERIC Educational Resources Information Center

    Singh, Satendra

    2013-01-01

    The Undergraduate Medical Program (Bachelor of Medicine and Bachelor of Surgery) at University College of Medical Sciences (Delhi, India) is a 4.5-yr, intense academic program where physiology is taught in the first year. To make the learning experience enriching, the Department of Physiology organizes four student seminars (two seminars/semester)…

  7. The "Other" Syllabus: Rendering Teaching Politics Visible in the Graduate Pedagogy Seminar

    ERIC Educational Resources Information Center

    Bailey, Lucy E.

    2010-01-01

    The author has explored the pedagogical possibilities of exploring doubt and ambiguity in graduate seminars in feminist pedagogy and teaching methods that she has been responsible for leading in several large public university settings. In these settings, faculty instituted the seminars in the graduate curriculum because they recognized the…

  8. Educational Programming: A Seminar for Young Adults with Cleft Lip and/or Palate.

    ERIC Educational Resources Information Center

    Imhoff, Michael; And Others

    1981-01-01

    The social service staff of the H. K. Cooper Clinic (Lancaster, Pennsylvania) conducted a seminar for young adults with cleft lip and palate (CL/P) and their families. The seminar was designed to respond to questions and concerns regarding the impact of CL/P on employment, social relations, and genetics. (SB)

  9. Fashioning Docile Teacher Bodies? The Strange Space of the "Staff Teaching Seminar"

    ERIC Educational Resources Information Center

    Grant, Barbara; Barrow, Mark

    2013-01-01

    For 40 years, the "staff teaching seminar" has aimed to prepare academics to meet the complex demands of university teaching. In Aotearoa/New Zealand (NZ), as elsewhere, the seminar emerged in the late 1960s-early 1970s, and preceded centrally funded academic development (AD) centres. Targeting new academics, the programme typically…

  10. Writing Seminars in the Content Area: In Search of Hemingway, Salinger, and Steinbeck.

    ERIC Educational Resources Information Center

    Workman, Brooke

    Intended for high school and college literature instructors, this book contains materials for intensive semester-long seminars on the lives and works of three American authors: Ernest Hemingway, J. D. Salinger, and John Steinbeck. Each seminar revolves around seven papers the students are required to write and defend aloud in front of the rest of…

  11. 1972 Minnesota NCTE (National Council of Teachers of English) Seminar on Research in English Education.

    ERIC Educational Resources Information Center

    Purves, Alan C., Ed.

    1973-01-01

    The articles in this journal relate the conference experience at the 1972 Minnesota National Council of Teachers of English (NCTE) Seminar on Research in English Education. Articles include "The New Research" by Peter S Rosenbaum (discussing the influence of the seminar experience and how it can precipitate new research); "Research…

  12. Preservice Teachers Reflect on the Authority Issue: A Case Study of a Student Teaching Seminar.

    ERIC Educational Resources Information Center

    Ullrich, Walter J.

    1992-01-01

    The growth of personal autonomy was studies in a reflective, inquiry-oriented teacher education program, analyzing how often beginning teachers displayed critical reflection when their self-directed seminar focused on authority. Findings indicated the nondirective seminar devoted to promoting personal autonomy and collaboration did not meet…

  13. Media Technologies and Language Learning. Proceedings of an IRAAL Seminar (Dublin, Ireland, November 25, 1989).

    ERIC Educational Resources Information Center

    Little, David, Ed.; O Meadhra, Bebhinn, Ed.

    A seminar sponsored by the Irish Association for Applied Linguistics on the role of media and media technologies in second and foreign language learning is reported. The organization of this report reflects the program of the seminar. Four plenary papers established some broad applied linguistic perspectives and presented an overview of recent…

  14. Seminar on Factual and Numerical Data Banks. Final Report (Rabat, Morocco, February 21-24, 1984).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific and Cultural Organization, Paris (France). General Information Programme.

    The proceedings of a seminar on factual and numerical data banks are described. Seminar objectives were to: (1) make potential users aware of the value of data banks in their respective disciplines and inform them of the tools available; (2) identify national and regional data bank requirements; and (3) define a strategy for development in this…

  15. Exploring the Evidence: Reporting Outcomes of Freshman Seminars. The Freshman Year Experience. Monograph Series Number 11.

    ERIC Educational Resources Information Center

    Barefoot, Betsy O., Ed.

    This document is a compendium of information from 34 colleges and universities on freshman seminar/student success courses and their outcomes and how institutions are evaluating and reporting on these programs. Freshman seminars or success courses are courses for entering students that aim to ease the student's transition to the college…

  16. Advocacy Seminar 2000 Course Book (Litchfield Park, Arizona, October 12-14, 2000).

    ERIC Educational Resources Information Center

    National School Boards Association, Alexandria, VA. Council of School Attorneys.

    This publication contains material from a 2-day seminar sponsored by the National School Boards Association's Council of School Attorneys. The notebook includes papers prepared by the seminar faculty, court documents, and other information related to the following topics: student threats; current issues of students with disabilities; the Family…

  17. Adaptation and Integration of Permanent Immigrants Seminar (4th, Geneva, Switzerland, May 8-11, 1979).

    ERIC Educational Resources Information Center

    International Migration, 1979

    1979-01-01

    This document contains working papers prepared for a seminar on Adaptation and Integration of Permanent Immigrants, along with general and specific recommendations formulated by seminar participants. Conclusions and recommendations from each paper are presented in English, French, and Spanish; the conference papers themselves are presented only in…

  18. The Value of a First-Year Seminar: International Students' Insights in Retrospect

    ERIC Educational Resources Information Center

    Andrade, Maureen S.

    2009-01-01

    Higher education institutions in the United States commonly offer first-year seminars to assist students with their transition to college. Seminars are one of several types of first-year interventions based on findings from persistence research identifying variables affecting student success. Diverse student populations such as international…

  19. Critical Conversations about Big Ideas in Art Using Paideia Seminar: A Focus on Early Elementary Settings

    ERIC Educational Resources Information Center

    Paul, Kristina Ayers; Tay, Juliana

    2016-01-01

    Paideia Seminar is a method for facilitating Socratic discussions about different types of texts, whether they be texts in the literal sense of the word or any other object that represents ideas or values. In this article, we describe how teachers can implement Paideia Seminar to spark deep thinking and rich discussion among early elementary…

  20. Educational Technology; An AED/INNOTECH Seminar. (Singapore, April 10-13, 1972.)

    ERIC Educational Resources Information Center

    Southeast Asian Ministers of Education Organization (Singapore). Regional Center for Educational Innovation and Technology.

    The full texts of the five major papers presented at the Singapore seminar comprise the body of this conference report. The seminar was jointly sponsored by the Academy for Educational Development (AED) and the Southeast Asian Ministers of Education Organization's (SEAMEO) Regional Center for Educational Innovation and Technology (INNOTECH): its…

  1. Methods of Comparative Androgogy: An International Expert Seminar (Bamberg, Germany, September 24-27, 1995).

    ERIC Educational Resources Information Center

    Charters, Margaret A.

    A seminar collected, shared, and discussed the consensus on definitions, standards, methods, and current problems in research methodology in comparative andragogy. Alfred Hierold opened the seminar with a brief history of the evolution of the University of Bamberg. The opening session focused on the importance of the researcher as a tool in…

  2. Able to Play: Mobilizing Communities for Children of All Abilities - Framing the Issue. Seminar Series

    ERIC Educational Resources Information Center

    W. K. Kellogg Foundation, 2005

    2005-01-01

    "Able to Play: Mobilizing Communities for Children of All Abilities" is one of a series of six seminars that the W.K. Kellogg Foundation hosted during 2005 to celebrate its 75th Anniversary year. The seminar, held in Lansing, Michigan, June 8-10, shared the lessons learned from the Able to Play Project. Advocates for people with…

  3. Interdisciplinary Research in a Dense Summer Bridge: The Role of a Writing Intensive Chemistry Seminar

    ERIC Educational Resources Information Center

    Waratuke, Stephen; Kling, Thomas

    2016-01-01

    We describe the structure of a writing-intensive, chemistry first year seminar designed to support a three week, research focused summer bridge program. Writing assignments in the seminar helped students understand their research activities, learn to conduct themselves as scientists, and reflect upon their lab work. The writing intensive seminar…

  4. The Impact of Peer Observation and Feedback on Technical Seminar Presentations: A Constructive Model

    ERIC Educational Resources Information Center

    Vani, V. Vijaya

    2015-01-01

    The present paper attempts to showcase the need and importance of peer observation and feedback in developing technical seminar presentation skills of the students at tertiary level. The paper endeavors to know whether a structured format will help students to know what they have to observe in the seminar presentations to give constructive…

  5. A new methodology for teaching clinical reasoning skills: problem solving clinical seminars.

    PubMed

    Struyf, E; Beullens, J; Van Damme, B; Janssen, P; Jaspaert, H

    2005-06-01

    In the final year of the medical curriculum of the Faculty of Medicine of the Katholieke Universiteit Leuven (Belgium), a new methodology for teaching clinical skills was introduced: Problem Solving Clinical Seminars (PSCS). Two eight-week series of 70 seminars were offered. Students prepared for the seminars in groups of five students who worked on one or more clinical cases followed by half-open questions. Additional information was collected individually. At the clinical seminar the solutions were presented and discussed, guided by a clinical teacher. A questionnaire was administered to investigate whether students perceive the new type of clinical seminars as a powerful learning environment. Students were satisfied with the new methodology. The importance of the postulated educational aspects--preparation, clinical case and the seminar--was confirmed. The preparation phase (self-study and group work) and the clinical seminar were experienced as two separate and important learning events. The implementation of the problem solving clinical seminars is considered by students to be a powerful learning environment and therefore a broader applicability of the PSCS methodology is recommended.

  6. O Taste and See: A Commemorative History of the Wye Seminars

    ERIC Educational Resources Information Center

    Holyer, Robert

    2014-01-01

    Each summer, faculty and academic deans from institutions across the country make their way to the Wye River campus of the Aspen Institute on the Eastern Shore of Maryland for a weeklong seminar. Described as professional development, it often turns out to be much more. The Wye Seminars have at their core a collection of classic texts--from Plato…

  7. Do-It-Yourself Guide to: A Solid Waste Seminar. Construction Plans and Use Guidelines.

    ERIC Educational Resources Information Center

    Quarry Hill Nature Center, Rochester, Minn.

    Ten learning stations dealing with solid waste comprise the seminar described in this booklet. At each station, students observe a display and then answer questions listed on their data sheets. Although the seminar was intended for junior high school students, it has been used successfully with upper elementary and adult participants. Among the…

  8. Cinemeducation in Psychiatry: A Seminar in Undergraduate Medical Education Combining a Movie, Lecture, and Patient Interview

    ERIC Educational Resources Information Center

    Kuhnigk, Olaf; Schreiner, Julia; Reimer, Jens; Emami, Roya; Naber, Dieter; Harendza, Sigrid

    2012-01-01

    Objective: Psychiatric educators are often faced with students' negative attitudes toward psychiatry. A new type of seminar has been established in order to enable students to gain a deeper understanding of psychiatric illness. Method: A "cinemeducation seminar," combining a movie, a lecture, and a patient interview, has been established as part…

  9. A New Graduate-Level Seminar to Prepare Students for the Next Step in Their Careers

    ERIC Educational Resources Information Center

    Fleming, Kelly L.; Matthaei, James; Pfaendtner, Jim

    2015-01-01

    Many new Ph.D.s are not prepared for a competitive interview process in seeking a first job. The University of Washington (UW) designed the Distinguished Young Scholars Seminar (DYSS) to rectify this problem with three goals: simulate a visit associated with many interviews and a one-hour seminar; make UW graduate students aware of where they fit…

  10. BAAL/CUP Seminars 2013/Text Trajectories--Developing Dynamic Approaches to Textual Analysis

    ERIC Educational Resources Information Center

    Maybin, Janet; Lillis, Theresa

    2015-01-01

    This seminar took place on 19 April, 2013 at the Centre for Language and Communication, Faculty of Language and Education Studies, The Open University. The seminar was coordinated by Janet Maybin and Theresa Lillis and there were 28 participants, including four postgraduate students, from universities in Britain, Belgium and South Africa.

  11. Intellectual Curiosity in Action: A Framework to Assess First-Year Seminars in Liberal Arts Settings

    ERIC Educational Resources Information Center

    Kolb, Kenneth H.; Longest, Kyle C.; Barnett, Jenna C.

    2014-01-01

    Fostering students' intellectual curiosity is a common goal of first-year seminar programs--especially in liberal arts settings. The authors propose an alternative method to assess this ambiguous, value-laden concept. Relying on data gathered from pre- and posttest in-depth interviews of 34 students enrolled in first-year seminars, they construct…

  12. Brazilian History and Culture Program, June 27 - August 2, 1992. Fulbright Hays Seminars Abroad Program.

    ERIC Educational Resources Information Center

    1992

    Sixteen participants in the Fulbright-Hays Seminar on the history and culture of Brazil traveled throughout Brazil from June 27 through August 2, 1992. At the end of the seminar 14 participants developed curriculum projects. Presented alphabetically by author, the 14 curricular projects cover aspects of Brazilian life and culture. Riva…

  13. An Evaluation of the Wasson Experiential Education Seminar, January-June 1974.

    ERIC Educational Resources Information Center

    Hart, Bill; Morris, John E.

    The Wasson Experiential Education Seminar, which was a direct outgrowth of the Colorado Outward Bound program to train and stimulate experiential education programs at the high school level, is described and evaluated in this report. A brief history of the development of the seminar and its program and learner goals are presented, along with…

  14. EVALUATION CONFERENCE ON LEADERSHIP DEVELOPMENT SEMINARS, PROGRAM PLANNING, BUDGETING AND EVALUATION. FINAL REPORT.

    ERIC Educational Resources Information Center

    HIMMELE, IRVIN H.; SMITH, CLODUS R.

    THIRTY-FOUR PARTICIPANTS REPRESENTING THE LEADERSHIP-ACTION LEVEL OF PERSONNEL THROUGHOUT THE NATION AND FROM THE U.S. OFFICE OF EDUCATION EVALUATED THE LEADERSHIP DEVELOPMENT AND PROGRAM PLANNING, AND BUDGETING SEMINARS HELD DURING 1967. GUIDELINES FOR SEMINAR EVALUATION WERE PRESENTED--(1) "RATIONALE AND RETROSPECT" BY N. EDWIN CRAWFORD, (2)…

  15. State Education & Environment Roundtable (SEER) Seminar (11th, Des Moines, Iowa, May 20-24, 2001).

    ERIC Educational Resources Information Center

    Lieberman, Gerald A.; Hoody, Linda L.

    This document reports on the 11th seminar of the State Education and Environment Roundtable (SEER). It consists of brief overviews of the daily discussions and presentations that were made at the seminar. Topics discussed include potential partnerships with national language arts organizations and associations, how environmental justice issues…

  16. The Benefits of Using Clickers in Small-Enrollment Seminar-Style Biology Courses

    ERIC Educational Resources Information Center

    Smith, Michelle K.; Trujillo, Caleb; Su, Tin Tin

    2011-01-01

    Although the use of clickers and peer discussion is becoming common in large-lecture undergraduate biology courses, their use is limited in small-enrollment seminar-style courses. To investigate whether facilitating peer discussion with clickers would add value to a small-enrollment seminar-style course, we evaluated their usefulness in an…

  17. A Study of Expectations and the Marital Quality of Participants of a Marital Enrichment Seminar

    ERIC Educational Resources Information Center

    Dixon, Lee J.; Gordon, Kristina Coop; Frousakis, Nikki N.; Schumm, Jeremiah A.

    2012-01-01

    This longitudinal study investigated the effects of expectations of effort of self and spouse on the marital quality of marital enrichment seminar participants. Self-report measures of marital quality, expectations regarding effort put into implementing what was learned during the seminar, amount of perceived effort, and satisfaction with effort…

  18. Internationalizing the Business Curriculum at Small Colleges: The Introductory Seminar Approach.

    ERIC Educational Resources Information Center

    Greenfield, Gerald Michael

    The University of Wisconsin-Parkside offered an experimental course on international business in seminar form as a means of trying an interdisciplinary venture in a new area without commitment to a course structure. The seminar was developed as part of the international studies program, which draws on existing courses in several disciplines, and…

  19. Impact of a Sophomore Seminar on the Desire of STEM Majors to Pursue a Science Career

    ERIC Educational Resources Information Center

    Sweeder, Ryan D.; Strong, Philip E.

    2012-01-01

    This study focuses on the impact of a sophomore seminar on STEM majors desire to pursue a science career. This seminar was a component in a broader scholarship program and focused on helping students gain a broader understanding of the process of science, expose students to a range of career options and provide opportunities for outside of class…

  20. Continuing Education of Women, Report of a Seminar (Toronto, Canada, March 1, 2, 3, 1973).

    ERIC Educational Resources Information Center

    Canadian Association for Adult Education, Toronto (Ontario).

    A report of a Seminar on Continuing Education of Women, held in March 1973 for Canadian women, is provided. The seminar was held to explore key issues in continuing education of women and to give guidelines to the Canadian Association for Adult Education (CAAE) as to relevant action that could be taken by the association. The contents of the…

  1. The Influence of Research within Religious Education: The Westhill Seminars, RE Professionals, Pupils and Schools

    ERIC Educational Resources Information Center

    Stern, Julian

    2014-01-01

    This article investigates the educational value of research studied by exploring the influence on a range of religious education professionals from a set of research seminars. The seminar series, sponsored by the Westhill Endowment Trust, has been running since 2004, bringing together teachers, advisors and higher education professionals working…

  2. Seminar on EU and energy held in Kohtu, Tallinn on June 13, 1997

    SciTech Connect

    1997-06-13

    This seminar addresses the energy policy of the European Union. The topics of the seminar include the energy strategy for Estonia; energy policy for the European Union; EU and Energy Markets; EC`s Climate Strategy; and Promotion of Energy Co-operation between Estonia and Finland.

  3. PREFACE: XV International Seminar on Physics and Chemistry of Solids

    NASA Astrophysics Data System (ADS)

    Kotur, Bogdan; Brągiel, Piotr

    2011-03-01

                      Logo     Logo The XV International Seminar on Physics and Chemistry of Solids (ISPCS15) was held from 7-10 June 2009 in Szklarska Poręba. Over eighty participants joined together in this mountain resort, at the foot of Szrenica peak, in the Polish part of the Sudety range. The majority or participants, in accordance with Seminar tradition, were from Ukraine and Poland. The pleasant and warm atmosphere created by the organizers was conducive to fruitful discussions, making new contacts and to joyful gatherings with friends. Even the rainy weather could not change that. Lectures and communications mainly covered the fields of solid state physics and chemistry, and possible applications. This time, however, a new section was introduced - one devoted to modern topics in liquid chemistry. Sometimes such a look over the borders of scientific specialties leads to interesting insights and original research solutions. Some of the papers presented during ISPCS15 are collected in this volume. Their diversity is representative of both the scope and character of this Seminar. The majority of the papers are research reports, but a review article and a paper focussed on problems connected with environmental protection are also included. This Conference has functioned for over a decade due to the permanent support of the rectors of both co-organizing universities: Professor Ivan Vakarchuk from Ivan Franko National University of Lviv and Professor Zygmunt Bąk from Jan Dlugosz University in Częstochowa. It is our pleasure, on behalf of the all participants of the past Seminars, to express our gratitude for this assistance. We would also like to thank all the invited speakers who kindly accepted our invitation, namely Professors Roman Gladyshevskii (Ivan Franko National University, Lviv, Ukraine), Mihaela Gulea (Laboratoire de Chimie Moleculare et Thioorganique, CAEN, France), Osama I Abd El-Salam (National Research

  4. Seminar in Critical Inquiry Twenty-first Century Nuclear Systems

    SciTech Connect

    LeMone, D. V.

    2002-02-25

    Critical Inquiry, has not only been successful in increasing university student retention rate but also in improving student academic performance beyond the initial year of transition into the University. The seminar course herein reviewed is a balanced combination of student personal and academic skill development combined with a solid background in modern nuclear systems. It is a valid premise to assume that entering students as well as stakeholders of the general public demonstrate equal levels of capability. Nuclear systems is designed to give a broad and basic knowledge of nuclear power, medical, industrial, research, and military systems (nuclear systems) in 20-25 hours.

  5. 2007 Plant Metabolic Engineering Gordon Conference and Graduate Research Seminar

    SciTech Connect

    Erich Grotewold

    2008-09-15

    Plant Metabolic Engineering is an emerging field that integrates a diverse range of disciplines including plant genetics, genomics, biochemistry, chemistry and cell biology. The Gordon-Kenan Graduate Research Seminar (GRS) in Plant Metabolic Engineering was initiated to provide a unique opportunity for future researcher leaders to present their work in this field. It also creates an environment allowing for peer-review and critical assessment of work without the intimidation usually associated with the presence of senior investigators. The GRS immediately precedes the Plant Metabolic Engineering Gordon Research Conference and will be for and by graduate students and post-docs, with the assistance of the organizers listed.

  6. Guido Beck, Alexandre Proca, and the Oporto Theoretical Physics Seminar

    NASA Astrophysics Data System (ADS)

    Dos Santos Fitas, Augusto José; Passos Videira, António Augusto

    2007-01-01

    We describe the pioneering attempts made by Ruy Luís Gomes (1905 1984) and other Portuguese physicists to develop a research and teaching seminar in theoretical physics at the University of Oporto in 1942 1944 under the leadership first of the refugee Austrian theoretical physicist Guido Beck (1903 1988) and then of the Romanian-French theoretical physicist Alexandre Proca (1896 1955). These efforts failed, however, owing to lack of sustained financial support from the Portuguese government and to the political repression of the Salazar regime, which dismissed Gomes and other prominent Portuguese physicists and other scientists from their university positions.

  7. NSCA light pollution seminar, Glasgow, 1999 November 25

    NASA Astrophysics Data System (ADS)

    Mizon, R.

    2000-04-01

    In July 1999 I was invited to speak at a seminar on 'Light Pollution in Scotland', to be held in Glasgow in November. The event was organised by the National Society for Clean Air and Protection of the Environment (NSCA).The Glasgow Central Hotel saw the gathering of over 100 local authority planners and environmental health officers from all over Scotland, and the CfDS presence included Dennis Proudman, of Taynuilt, Argyll, who has done much to spread awareness of the problem of light pollution in the Argyll area, not least with his series of articles in the Oban Times.

  8. Design and outcomes of an acoustic data visualization seminar.

    PubMed

    Robinson, Philip W; Pätynen, Jukka; Haapaniemi, Aki; Kuusinen, Antti; Leskinen, Petri; Zan-Bi, Morley; Lokki, Tapio

    2014-01-01

    Recently, the Department of Media Technology at Aalto University offered a seminar entitled Applied Data Analysis and Visualization. The course used spatial impulse response measurements from concert halls as the context to explore high-dimensional data visualization methods. Students were encouraged to represent source and receiver positions, spatial aspects, and temporal development of sound fields, frequency characteristics, and comparisons between halls, using animations and interactive graphics. The primary learning objectives were for the students to translate their skills across disciplines and gain a working understanding of high-dimensional data visualization techniques. Accompanying files present examples of student-generated, animated and interactive visualizations.

  9. Children's Mental Health: Strategies for Providing High Quality and Cost-Effective Care. North Carolina Family Impact Seminar

    ERIC Educational Resources Information Center

    Douglass, Nam, Ed.; Owen, Jenni, Ed.; Berlin, Lisa J., Ed.

    2006-01-01

    This report represents the second North Carolina Family Impact Seminar in a series designed to connect research and state policymaking. Family Impact Seminars analyze the impact an issue, policy, or program may have on families. This Family Impact Seminar briefing report discusses strategies for providing high quality and cost-effective children's…

  10. Literature Seminars for Gifted and Talented Students: Creating Exciting Units for Students to Go beyond the Usual Course of Study.

    ERIC Educational Resources Information Center

    Dixon, Felicia

    1994-01-01

    This article describes the structure and operation of three literature seminars offered in the English curriculum at the Indiana Academy for Science, Mathematics, and Humanities. The seminar approach puts the responsibility on the student and fosters creativity, thinking skills, and problem solving. The seminars include:…

  11. Extracting Information from Folds in Rocks.

    ERIC Educational Resources Information Center

    Hudleston, Peter John

    1986-01-01

    Describes the three processes of folding in rocks: buckling, bending, and passive folding. Discusses how geometrical properties and strain distributions help to identify which processes produce natural folds, and also provides information about the mechanical properties of rocks, and the sense of shear in shear zones. (TW)

  12. Dynamics of Folds in the Plane

    ERIC Educational Resources Information Center

    Krylov, Nikolai A.; Rogers, Edwin L.

    2011-01-01

    Take a strip of paper and fold a crease intersecting the long edges, creating two angles. Choose one edge and consider the angle with the crease. Fold the opposite edge along the crease, creating a new crease that bisects the angle. Fold again, this time using the newly created crease and the initial edge, creating a new angle along the chosen…

  13. Teamwork Seminar Practice to Foster Diversified Thinking and Leadership Among Students

    NASA Astrophysics Data System (ADS)

    Maruyama, Naoki; Yoshida, Kazumi; Yamao, Hidenori

    A new course entitled “Mechanical Engineering Seminar” has begun in the Department of Mechanical Engineering, Mie University. This course consists of three parts, a teamwork seminar, a creative design seminar and a comprehensive achievement examination. Its aim is to foster a broad social and international outlook, ethical thinking, autonomy, partnership, leadership, presentation ability, originality, overall creativity in students, and to help them become aware of their real ability. The teaching method used in this seminar is based on problem-based learning (PBL) , and pro-active student participation is required. The purpose of this paper is to report the features, teaching method and educational effectiveness of the teamwork seminar, which seeks to educate students with a broad, diversified outlook. The results of a student questionnaire show that these new fields of study stimulate students' will to learn, and they express general satisfaction with the seminar.

  14. Understanding Protein Non-Folding

    PubMed Central

    Uversky, Vladimir N.; Dunker, A. Keith

    2010-01-01

    This review describes the family of intrinsically disordered proteins, members of which fail to form rigid 3-D structures under physiological conditions, either along their entire lengths or only in localized regions. Instead, these intriguing proteins/regions exist as dynamic ensembles within which atom positions and backbone Ramachandran angles exhibit extreme temporal fluctuations without specific equilibrium values. Many of these intrinsically disordered proteins are known to carry out important biological functions which, in fact, depend on the absence of specific 3-D structure. The existence of such proteins does not fit the prevailing structure-function paradigm, which states that unique 3-D structure is a prerequisite to function. Thus, the protein structure-function paradigm has to be expanded to include intrinsically disordered proteins and alternative relationships among protein sequence, structure, and function. This shift in the paradigm represents a major breakthrough for biochemistry, biophysics and molecular biology, as it opens new levels of understanding with regard to the complex life of proteins. This review will try to answer the following questions: How were intrinsically disordered proteins discovered? Why don't these proteins fold? What is so special about intrinsic disorder? What are the functional advantages of disordered proteins/regions? What is the functional repertoire of these proteins? What are the relationships between intrinsically disordered proteins and human diseases? PMID:20117254

  15. Effectiveness of modified seminars as a teaching-learning method in pharmacology

    PubMed Central

    Palappallil, Dhanya Sasidharan; Sushama, Jitha; Ramnath, Sai Nathan

    2016-01-01

    Context: Student-led seminars (SLS) are adopted as a teaching-learning (T-L) method in pharmacology. Previous studies assessing the feedback on T-L methods in pharmacology points out that the traditional seminars consistently received poor feedbacks as they were not favorite among the students. Aims: This study aimed to obtain feedback on traditional SLS, introduce modified SLS and compare the modified seminars with the traditional ones. Settings and Design: This was a prospective interventional study done for 2 months in medical undergraduates of fifth semester attending Pharmacology seminars at a Government Medical College in South India. Subjects and Methods: Structured questionnaire was used to elicit feedback from participants. The responses were coded on 5-point Likert scale. Modifications in seminar sessions such as role plays, quiz, tests, group discussion, and patient-oriented problem-solving exercises were introduced along with SLS. Statistical Analysis Used: The data were analyzed using SPSS version 16. The descriptive data were expressed using frequencies and percentages. Wilcoxon signed rank test, and Friedman tests were used to compare traditional with modified seminars. Results: The participants identified interaction as the most important component of a seminar. Majority opined that the teacher should summarize at the end of SLS. Student feedback shows that modified seminars created more interest, enthusiasm, and inspiration to learn the topic when compared to traditional SLS. They also increased peer coordination and group dynamics. Students opined that communication skills and teacher-student interactions were not improved with modified seminars. Conclusions: Interventions in the form of modified SLS may be adopted to break the monotony of traditional seminars through active participation, peer interaction, and teamwork. PMID:27563587

  16. 3D fold growth in transpression

    NASA Astrophysics Data System (ADS)

    Frehner, Marcel

    2016-12-01

    Geological folds in transpression are inherently 3D structures; hence their growth and rotation behavior is studied using 3D numerical finite-element simulations. Upright single-layer buckle folds in Newtonian materials are considered, which grow from an initial point-like perturbation due to a combination of in-plane shortening and shearing (i.e., transpression). The resulting fold growth exhibits three components: (1) fold amplification (vertical), (2) fold elongation (parallel to fold axis), and (3) sequential fold growth (perpendicular to axial plane) of new anti- and synforms adjacent to the initial fold. Generally, the fold growth rates are smaller for shearing-dominated than for shortening-dominated transpression. In spite of the growth rate, the folding behavior is very similar for the different convergence angles. The two lateral directions always exhibit similar growth rates implying that the bulk fold structure occupies an increasing roughly circular area. Fold axes are always parallel to the major horizontal principal strain axis (λ→max, i.e., long axis of the horizontal finite strain ellipse), which is initially also parallel to the major horizontal instantaneous stretching axis (ISA→max). After initiation, the fold axes rotate together with λ→max. Sequential folds appearing later do not initiate parallel to ISA→max, but parallel to λ→max, i.e. parallel to the already existing folds, and also rotate with λ→max. Therefore, fold axes do not correspond to passive material lines and hinge migration takes place as a consequence. The fold axis orientation parallel to λ→max is independent of convergence angle and viscosity ratio. Therefore, a triangular relationship between convergence angle, amount of shortening, and fold axis orientation exists. If two of these values are known, the third can be determined. This relationship is applied to the Zagros fold-and-thrust-belt to estimate the degree of strain partitioning between the Simply

  17. Folding of viscous sheets and filaments

    NASA Astrophysics Data System (ADS)

    Skorobogatiy, M.; Mahadevan, L.

    2000-12-01

    We consider the nonlinear folding behavior of a viscous filament or a sheet under the influence of an external force such as gravity. Everyday examples of this phenomenon are provided by the periodic folding of a sheet of honey as it impinges on toast, or the folding of a stream of shampoo as it falls on one's hand. To understand the evolution of a fold, we formulate and solve a free-boundary problem for the phenomenon, give scaling laws for the size of the folds and the frequency with which they are laid out, and verify these experimentally.

  18. Anatomy and Histology of an Epicanthal Fold.

    PubMed

    Park, Jae Woo; Hwang, Kun

    2016-06-01

    The aim of this study is to elucidate the precise anatomical and histological detail of the epicanthal fold.Thirty-two hemifaces of 16 Korean adult cadavers were used in this study (30 hemifaces with an epicanthal fold, 2 without an epicanthal fold). In 2 patients who had an epicanthoplasty, the epicanthal folds were sampled.In a dissection, the periorbital skin and subcutaneous tissues were removed and the epicanthal fold was observed in relation to each part of the orbicularis oculi muscle. Specimens including the epicanthal fold were embeddedin in paraffin, sectioned at 10 um, and stained with Hematoxylin-Eosin. The horizontal section in the level of the paplebral fissure was made and the prepared slides were observed under a light microscope.In the specimens without an epicanthal fold, no connection between the upper preseptal muscle and the lower preseptal muscle was found. In the specimens with an epicanthal fold, a connection of the upper preseptal muscle to the lower preseptal muscle was observed. It was present in all 15 hemifaces (100%). There was no connection between the pretarsal muscles. In a horizontal section, the epicanthal fold was composed of 3 compartments: an outer skin lining, a core structure, and an innerskin lining. The core structure was mainly composed of muscular fibers and fibrotic tissue and they were intermingled.Surgeons should be aware of the anatomical details of an epicanthal fold. In removing or reconstructing an epicanthal fold, the fibromuscular core band should also be removed or reconstructed.

  19. Controlled Folding of Single Crystal Graphene.

    PubMed

    Wang, Bin; Huang, Ming; Kim, Na Yeon; Cunning, Benjamin V; Huang, Yuan; Qu, Deshun; Chen, Xianjue; Jin, Sunghwan; Biswal, Mandakini; Zhang, Xu; Lee, Sun Hwa; Lim, Hyunseob; Yoo, Won Jong; Lee, Zonghoon; Ruoff, Rodney S

    2017-03-08

    Folded graphene in which two layers are stacked with a twist angle between them has been predicted to exhibit unique electronic, thermal, and magnetic properties. We report the folding of a single crystal monolayer graphene film grown on a Cu(111) substrate by using a tailored substrate having a hydrophobic region and a hydrophilic region. Controlled film delamination from the hydrophilic region was used to prepare macroscopic folded graphene with good uniformity on the millimeter scale. This process was used to create many folded sheets each with a defined twist angle between the two sheets. By identifying the original lattice orientation of the monolayer graphene on Cu foil, or establishing the relation between the fold angle and twist angle, this folding technique allows for the preparation of twisted bilayer graphene films with defined stacking orientations and may also be extended to create folded structures of other two-dimensional nanomaterials.

  20. The Promise of Literacy. Campaigns, Programs and Projects. Report of the International Seminar on Campaigning for Literacy (Udaipur, India, January 4-11, 1982).

    ERIC Educational Resources Information Center

    Bhola, H. S.; And Others

    This report on the International Seminar on Campaigning for Literacy at Udaipur, India is divided into three main parts. Part 1 describes the context and background of the seminar, its specific objectives, and the organization and procedures of the seminar. Part 2 provides an overview of the seminar proceedings. The inaugural statements are…

  1. Stress and strain evolution of folding rocks

    NASA Astrophysics Data System (ADS)

    Llorens, Maria-Gema; Griera, Albert; Bons, Paul; Gomez-Rivas, Enrique; Weikusat, Ilka

    2015-04-01

    One of the main objectives of structural geology is to unravel rock deformation histories. Fold shapes can be used to estimate the orientation and amount of strain associated with folding. However, much more information on rheology and kinematics can potentially be extracted from fold geometries (Llorens et al., 2013a). We can study the development of folds, quantify the relationships between the different parameters that determine their geometries and estimate their mechanical evolution. This approach allows us to better understand and predict not only rock but also ice deformation. One of the main parameters in fold development is the viscosity contrast between the folding layer and the matrix in which it is embedded (m), since it determines the initial fold wavelength and the amplification rate of the developing folds. Moreover, non-linear viscous rheology influences fold geometry too (Llorens et al., 2013b). We present a series of 2-dimensional simulations of folding of viscous single layers in pure and simple shear. We vary different parameters in order to compare and determine their influence on the resulting fold patterns and the associated mechanical response of the material. To perform these simulations we use the software platform ELLE (www.elle.ws) with the non-linear viscous finite element code BASIL. The results show that layers thicken at the beginning of deformation in all simulations, and visible folds start earlier or later depending on the viscosity contrast. When folds start to nucleate the layer maximum shear strain decreases, moving away from the theoretical trend for homogeneous strain (no folding). This allows the accurate determination of the onset of folding. Maximum deviatoric stresses are higher in power-law than in linear-viscosity materials, and it is initially double in pure shear than in simple shear conditions. Therefore, folding a competent layer requires less work in simple than in pure shear. The maximum deviatoric stress

  2. Kinetic partitioning mechanism of HDV ribozyme folding.

    PubMed

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing

    2014-01-14

    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  3. Kinetic partitioning mechanism of HDV ribozyme folding

    SciTech Connect

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing

    2014-01-14

    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  4. Kinetic partitioning mechanism of HDV ribozyme folding

    NASA Astrophysics Data System (ADS)

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing

    2014-01-01

    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  5. Asymmetric hindwing foldings in rove beetles.

    PubMed

    Saito, Kazuya; Yamamoto, Shuhei; Maruyama, Munetoshi; Okabe, Yoji

    2014-11-18

    Foldable wings of insects are the ultimate deployable structures and have attracted the interest of aerospace engineering scientists as well as entomologists. Rove beetles are known to fold their wings in the most sophisticated ways that have right-left asymmetric patterns. However, the specific folding process and the reason for this asymmetry remain unclear. This study reveals how these asymmetric patterns emerge as a result of the folding process of rove beetles. A high-speed camera was used to reveal the details of the wing-folding movement. The results show that these characteristic asymmetrical patterns emerge as a result of simultaneous folding of overlapped wings. The revealed folding mechanisms can achieve not only highly compact wing storage but also immediate deployment. In addition, the right and left crease patterns are interchangeable, and thus each wing internalizes two crease patterns and can be folded in two different ways. This two-way folding gives freedom of choice for the folding direction to a rove beetle. The use of asymmetric patterns and the capability of two-way folding are unique features not found in artificial structures. These features have great potential to extend the design possibilities for all deployable structures, from space structures to articles of daily use.

  6. Viscoelastic properties of the false vocal fold

    NASA Astrophysics Data System (ADS)

    Chan, Roger W.

    2004-05-01

    The biomechanical properties of vocal fold tissues have been the focus of many previous studies, as vocal fold viscoelasticity critically dictates the acoustics and biomechanics of phonation. However, not much is known about the viscoelastic response of the ventricular fold or false vocal fold. It has been shown both clinically and in computer simulations that the false vocal fold may contribute significantly to the aerodynamics and sound generation processes of human voice production, with or without flow-induced oscillation of the false fold. To better understand the potential role of the false fold in phonation, this paper reports some preliminary measurements on the linear and nonlinear viscoelastic behavior of false vocal fold tissues. Linear viscoelastic shear properties of human false fold tissue samples were measured by a high-frequency controlled-strain rheometer as a function of frequency, and passive uniaxial tensile stress-strain response of the tissue samples was measured by a muscle lever system as a function of strain and loading rate. Elastic moduli (Young's modulus and shear modulus) of the false fold tissues were calculated from the measured data. [Work supported by NIH.

  7. Folding of synthetic homogeneous glycoproteins in the presence of a glycoprotein folding sensor enzyme.

    PubMed

    Dedola, Simone; Izumi, Masayuki; Makimura, Yutaka; Seko, Akira; Kanamori, Akiko; Sakono, Masafumi; Ito, Yukishige; Kajihara, Yasuhiro

    2014-03-10

    UDP-glucose:glycoprotein glucosyltransferase (UGGT) plays a key role in recognizing folded and misfolded glycoproteins in the glycoprotein quality control system of the endoplasmic reticulum. UGGT detects misfolded glycoproteins and re-glucosylates them as a tag for misfolded glycoproteins. A flexible model to reproduce in vitro folding of a glycoprotein in the presence of UGGT in a mixture containing correctly folded, folding intermediates, and misfolded glycoproteins is described. The data demonstrates that UGGT can re-glucosylate all intermediates in the in vitro folding experiments, thus indicating that UGGT inspects not only final folded products, but also the glycoprotein folding intermediates.

  8. Evaluation of hands-on seminar for reduced port surgery using fresh porcine cadaver model

    PubMed Central

    Poudel, Saseem; Kurashima, Yo; Shichinohe, Toshiaki; Kitashiro, Shuji; Kanehira, Eiji; Hirano, Satoshi

    2016-01-01

    BACKGROUND: The use of various biological and non-biological simulators is playing an important role in training modern surgeons with laparoscopic skills. However, there have been few reports of the use of a fresh porcine cadaver model for training in laparoscopic surgical skills. The purpose of this study was to report on a surgical training seminar on reduced port surgery using a fresh cadaver porcine model and to assess its feasibility and efficacy. MATERIALS AND METHODS: The hands-on seminar had 10 fresh porcine cadaver models and two dry boxes. Each table was provided with a unique access port and devices used in reduced port surgery. Each group of 2 surgeons spent 30 min at each station, performing different tasks assisted by the instructor. The questionnaire survey was done immediately after the seminar and 8 months after the seminar. RESULTS: All the tasks were completed as planned. Both instructors and participants were highly satisfied with the seminar. There was a concern about the time allocated for the seminar. In the post-seminar survey, the participants felt that the number of reduced port surgeries performed by them had increased. CONCLUSION: The fresh cadaver porcine model requires no special animal facility and can be used for training in laparoscopic procedures. PMID:27279391

  9. Optical methods for measuring DNA folding

    NASA Astrophysics Data System (ADS)

    Smith, Adam D.; Ukogu, Obinna A.; Devenica, Luka M.; White, Elizabeth D.; Carter, Ashley R.

    2017-03-01

    One of the most important biological processes is the dynamic folding and unfolding of deoxyribonucleic acid (DNA). The folding process is crucial for DNA to fit within the boundaries of the cell, while the unfolding process is essential for DNA replication and transcription. To accommodate both processes, the cell employs a highly active folding mechanism that has been the subject of intense study over the last few decades. Still, many open questions remain. What are the pathways for folding or unfolding? How does the folding equilibrium shift? And, what is the energy landscape for a particular process? Here, we review these emerging questions and the in vitro, optical methods that have provided answers, introducing the topic for those physicists seeking to step into biology. Specifically, we discuss two iconic experiments for DNA folding, the tethered particle motion (TPM) experiment and the optical tweezers experiment.

  10. Structural features of protein folding nuclei.

    PubMed

    Garbuzynskiy, S O; Kondratova, M S

    2008-03-05

    A crucial event of protein folding is the formation of a folding nucleus. We demonstrate the presence of a considerable coincidence between the location of folding nuclei and the location of so-called "root structural motifs", which have unique overall folds and handedness. In the case of proteins with a single root structural motif, the involvement in the formation of a folding nucleus is in average significantly higher for amino acids residues that are in root structural motifs, compared to residues in other parts of the protein. The tests carried out revealed that the observed difference is statistically reliable. Thus, a structural feature that corresponds to the protein folding nucleus is now found.

  11. Implicit modeling of folds and overprinting deformation

    NASA Astrophysics Data System (ADS)

    Laurent, Gautier; Ailleres, Laurent; Grose, Lachlan; Caumon, Guillaume; Jessell, Mark; Armit, Robin

    2016-12-01

    Three-dimensional structural modeling is gaining importance for a broad range of quantitative geoscientific applications. However, existing approaches are still limited by the type of structural data they are able to use and by their lack of structural meaning. Most techniques heavily rely on spatial data for modeling folded layers, but are unable to completely use cleavage and lineation information for constraining the shape of modeled folds. This lack of structural control is generally compensated by expert knowledge introduced in the form of additional interpretive data such as cross-sections and maps. With this approach, folds are explicitly designed by the user instead of being derived from data. This makes the resulting structures subjective and deterministic. This paper introduces a numerical framework for modeling folds and associated foliations from typical field data. In this framework, a parametric description of fold geometry is incorporated into the interpolation algorithm. This way the folded geometry is implicitly derived from observed data, while being controlled through structural parameters such as fold wavelength, amplitude and tightness. A fold coordinate system is used to support the numerical description of fold geometry and to modify the behavior of classical structural interpolators. This fold frame is constructed from fold-related structural elements such as axial foliations, intersection lineations, and vergence. Poly-deformed terranes are progressively modeled by successively modeling each folding event going backward through time. The proposed framework introduces a new modeling paradigm, which enables the building of three-dimensional geological models of complex poly-deformed terranes. It follows a process based on the structural geologist approach and is able to produce geomodels that honor both structural data and geological knowledge.

  12. Arts, health & wellbeing: reflections on a national seminar series and building a UK research network

    PubMed Central

    Stickley, Theo; Parr, Hester; Atkinson, Sarah; Daykin, Norma; Clift, Stephen; De Nora, Tia; Hacking, Sue; Camic, Paul M; Joss, Tim; White, Mike; Hogan, Susan J

    2017-01-01

    Abstract An account is provided of a UK national seminar series on Arts, Health and Wellbeing funded by the Economic and Social Research Council during 2012–13. Four seminars were organised addressing current issues and challenges facing the field. Details of the programme and its outputs are available online. A central concern of the seminar programme was to provide a foundation for creating a UK national network for researchers in the field to help promote evidence-based policy and practice. With funding from Lankelly Chase Foundation, and the support of the Royal Society for Public Health, a Special interest Group for Arts, Health and Wellbeing was launched in 2015. PMID:28163778

  13. Arts, health & wellbeing: reflections on a national seminar series and building a UK research network.

    PubMed

    Stickley, Theo; Parr, Hester; Atkinson, Sarah; Daykin, Norma; Clift, Stephen; De Nora, Tia; Hacking, Sue; Camic, Paul M; Joss, Tim; White, Mike; Hogan, Susan J

    2017-01-02

    An account is provided of a UK national seminar series on Arts, Health and Wellbeing funded by the Economic and Social Research Council during 2012-13. Four seminars were organised addressing current issues and challenges facing the field. Details of the programme and its outputs are available online. A central concern of the seminar programme was to provide a foundation for creating a UK national network for researchers in the field to help promote evidence-based policy and practice. With funding from Lankelly Chase Foundation, and the support of the Royal Society for Public Health, a Special interest Group for Arts, Health and Wellbeing was launched in 2015.

  14. Deterministic Folding in Stiff Elastic Membranes

    NASA Astrophysics Data System (ADS)

    Tallinen, T.; Åström, J. A.; Timonen, J.

    2008-09-01

    Crumpled membranes have been found to be characterized by complex patterns of spatially seemingly random facets separated by narrow ridges of high elastic energy. We demonstrate by numerical simulations that compression of stiff elastic membranes with small randomness in their initial configurations leads to either random ridge configurations (high entropy) or nearly deterministic folds (low elastic energy). For folding with symmetric ridge configurations to appear in part of the crumpling processes, the crumpling rate must be slow enough. Folding stops when the thickness of the folded structure becomes important, and crumpling continues thereafter as a random process.

  15. Protein Folding and Self-Organized Criticality

    NASA Astrophysics Data System (ADS)

    Bajracharya, Arun; Murray, Joelle

    Proteins are known to fold into tertiary structures that determine their functionality in living organisms. However, the complex dynamics of protein folding and the way they consistently fold into the same structures is not fully understood. Self-organized criticality (SOC) has provided a framework for understanding complex systems in various systems (earthquakes, forest fires, financial markets, and epidemics) through scale invariance and the associated power law behavior. In this research, we use a simple hydrophobic-polar lattice-bound computational model to investigate self-organized criticality as a possible mechanism for generating complexity in protein folding.

  16. Distinguishing between sequential and nonsequentially folded proteins: implications for folding and misfolding.

    PubMed Central

    Tsai, C. J.; Maizel, J. V.; Nussinov, R.

    1999-01-01

    We describe here an algorithm for distinguishing sequential from nonsequentially folding proteins. Several experiments have recently suggested that most of the proteins that are synthesized in the eukaryotic cell may fold sequentially. This proposed folding mechanism in vivo is particularly advantageous to the organism. In the absence of chaperones, the probability that a sequentially folding protein will misfold is reduced significantly. The problem we address here is devising a procedure that would differentiate between the two types of folding patterns. Footprints of sequential folding may be found in structures where consecutive fragments of the chain interact with each other. In such cases, the folding complexity may be viewed as being lower. On the other hand, higher folding complexity suggests that at least a portion of the polypeptide backbone folds back upon itself to form three-dimensional (3D) interactions with noncontiguous portion(s) of the chain. Hence, we look at the mechanism of folding of the molecule via analysis of its complexity, that is, through the 3D interactions formed by contiguous segments on the polypeptide chain. To computationally splice the structure into consecutively interacting fragments, we either cut it into compact hydrophobic folding units or into a set of hypothetical, transient, highly populated, contiguous fragments ("building blocks" of the structure). In sequential folding, successive building blocks interact with each other from the amino to the carboxy terminus of the polypeptide chain. Consequently, the results of the parsing differentiate between sequentially vs. nonsequentially folded chains. The automated assessment of the folding complexity provides insight into both the likelihood of misfolding and the kinetic folding rate of the given protein. In terms of the funnel free energy landscape theory, a protein that truly follows the mechanism of sequential folding, in principle, encounters smoother free energy barriers

  17. Proceedings of the Space Station Freedom Clinical Experts Seminar

    NASA Technical Reports Server (NTRS)

    Billica, Roger P. (Editor); Lloyd, Charles W. (Editor); Doarn, Charles R. (Editor)

    1991-01-01

    These are the proceedings of the Space Station Freedom Health Maintenance Facility 1990 Clinical Experts Seminar held August 27-29, 1990, at the Nassau Bay Hilton, Houston, Texas. Contained within are the agenda, list of medical consultants, executive summary, individual presentations, and the comments generated from the working groups. Issues include the adequacy of current Health Maintenance Facility for Space Station Freedom; impact of having, or not having, an ACRV or physician on board Space Station Freedom; new and developing technologies, techniques, and medications and their impact on the evolving Space Station Freedom, considerations surrounding x-ray, ultrasound, lab, decontamination, blood transfusion, nutrition, safe-haven, computer/telemedicine; suggestions as to how to train the Crew Medical Officer; and, how the consultant network will interface over the next several years.

  18. Retinal and Choroidal Folds in Papilledema

    PubMed Central

    Sibony, Patrick A.; Kupersmith, Mark J.; Feldon, Steven E.; Wang, Jui-Kai; Garvin, Mona

    2015-01-01

    Purpose To determine the frequency, patterns, associations, and biomechanical implications of retinal and choroidal folds in papilledema due to idiopathic intracranial hypertension (IIH). Methods Retinal and choroidal folds were studied in patients enrolled in the IIH Treatment Trial using fundus photography (n = 165 study eyes) and spectral-domain optical coherence tomography (SD-OCT; n = 125). We examined the association between folds and peripapillary shape, retinal nerve fiber layer (RNFL) thickness, disc volume, Frisén grade, acuity, perimetric mean deviation, intraocular pressure, intracranial pressure, and refractive error. Results We identified three types of folds in IIH patients with papilledema: peripapillary wrinkles (PPW), retinal folds (RF), and choroidal folds (CF). Frequency, with photos, was 26%, 19%, and 1%, respectively; SD-OCT frequency was 46%, 47%, and 10%. At least one type of fold was present in 41% of patients with photos and 73% with SD-OCT. Spectral-domain OCT was more sensitive. Structural parameters related to the severity of papilledema were associated with PPW and RF, whereas anterior deformation of the peripapillary RPE/basement membrane layer was associated with CF and RF. Folds were not associated with vision loss at baseline. Conclusions Folds in papilledema are biomechanical signs of stress/strain on the optic nerve head and load-bearing structures induced by intracranial hypertension. Folds are best imaged with SD-OCT. The patterns of retinal and choroidal folds are the products of a complex interplay between the degree of papilledema and anterior deformation of the load-bearing structures (sclera and possibly the lamina cribrosa), both modulated by structural geometry and material properties of the optic nerve head. (ClinicalTrials.gov number, NCT01003639.) PMID:26335066

  19. Guiding the folding pathway of DNA origami

    NASA Astrophysics Data System (ADS)

    Dunn, Katherine E.; Dannenberg, Frits; Ouldridge, Thomas E.; Kwiatkowska, Marta; Turberfield, Andrew J.; Bath, Jonathan

    2015-09-01

    DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short `staple' strands. Its guiding design principle is that the target structure is the single most stable configuration. The folding transition is cooperative and, as in the case of proteins, is governed by information encoded in the polymer sequence. A typical origami folds primarily into the desired shape, but misfolded structures can kinetically trap the system and reduce the yield. Although adjusting assembly conditions or following empirical design rules can improve yield, well-folded origami often need to be separated from misfolded structures. The problem could in principle be avoided if assembly pathway and kinetics were fully understood and then rationally optimized. To this end, here we present a DNA origami system with the unusual property of being able to form a small set of distinguishable and well-folded shapes that represent discrete and approximately degenerate energy minima in a vast folding landscape, thus allowing us to probe the assembly process. The obtained high yield of well-folded origami structures confirms the existence of efficient folding pathways, while the shape distribution provides information about individual trajectories through the folding landscape. We find that, similarly to protein folding, the assembly of DNA origami is highly cooperative; that reversible bond formation is important in recovering from transient misfoldings; and that the early formation of long-range connections can very effectively enforce particular folds. We use these insights to inform the design of the system so as to steer assembly towards desired structures. Expanding the rational design process to include the assembly pathway should thus enable more reproducible synthesis, particularly when targeting more complex structures. We anticipate that this expansion will be essential if DNA origami is to continue its

  20. A Computational Model of Cerebral Cortex Folding

    PubMed Central

    Nie, Jingxin; Guo, Lei; Li, Gang; Faraco, Carlos; Miller, L Stephen; Liu, Tianming

    2010-01-01

    The geometric complexity and variability of the human cerebral cortex has long intrigued the scientific community. As a result, quantitative description of cortical folding patterns and the understanding of underlying folding mechanisms have emerged as important research goals. This paper presents a computational 3-dimensional geometric model of cerebral cortex folding initialized by MRI data of a human fetal brain and deformed under the governance of a partial differential equation modeling cortical growth. By applying different simulation parameters, our model is able to generate folding convolutions and shape dynamics of the cerebral cortex. The simulations of this 3D geometric model provide computational experimental support to the following hypotheses: 1) Mechanical constraints of the skull regulate the cortical folding process. 2) The cortical folding pattern is dependent on the global cell growth rate of the whole cortex. 3) The cortical folding pattern is dependent on relative rates of cell growth in different cortical areas. 4) The cortical folding pattern is dependent on the initial geometry of the cortex. PMID:20167224

  1. Fractures Sets Associated to Buckle Folds

    NASA Astrophysics Data System (ADS)

    Liu, X.; Eckert, A.; Connolly, P. T.

    2014-12-01

    Buckle folds of single and multilayered sedimentary strata in the literature are commonly associated to a variety of different fracture sets, both shear and tensile. Amongst the most noticeable fractures are tensile fractures occurring in the outer hinges of the fold crest and shear fractures in the bottom of fold hinge zones. These fractures are well explained and understood by the extensional and compressional strain/stress pattern in the fold hinge. However, tensile fractures parallel to the fold axis, tensile fractures cutting through the limb, normal faults on the fold hinge, and shear fractures of different orientations in the fold limb cannot intuitively be linked to the stress regime occurring during the buckling process. This study utilizes a 2D and 3D finite element modeling approach using Maxwell visco-elastic rheology to study the stress conditions during single and multilayer buckling for each fracture set to occur. The numerical simulations include sensitivity analyses on material parameters such as permeability, viscosity and overburden thickness. For fracture sets not likely to occur during the buckling process pre- and post folding processes such as initial overpressure, extensional unfolding, and erosional unloading are studied.

  2. Microsecond subdomain folding in dihydrofolate reductase.

    PubMed

    Arai, Munehito; Iwakura, Masahiro; Matthews, C Robert; Bilsel, Osman

    2011-07-08

    The characterization of microsecond dynamics in the folding of multisubdomain proteins has been a major challenge in understanding their often complex folding mechanisms. Using a continuous-flow mixing device coupled with fluorescence lifetime detection, we report the microsecond folding dynamics of dihydrofolate reductase (DHFR), a two-subdomain α/β/α sandwich protein known to begin folding in this time range. The global dimensions of early intermediates were monitored by Förster resonance energy transfer, and the dynamic properties of the local Trp environments were monitored by fluorescence lifetime detection. We found that substantial collapse occurs in both the locally connected adenosine binding subdomain and the discontinuous loop subdomain within 35 μs of initiation of folding from the urea unfolded state. During the fastest observable ∼550 μs phase, the discontinuous loop subdomain further contracts, concomitant with the burial of Trp residue(s), as both subdomains achieve a similar degree of compactness. Taken together with previous studies in the millisecond time range, a hierarchical assembly of DHFR--in which each subdomain independently folds, subsequently docks, and then anneals into the native conformation after an initial heterogeneous global collapse--emerges. The progressive acquisition of structure, beginning with a continuously connected subdomain and spreading to distal regions, shows that chain entropy is a significant organizing principle in the folding of multisubdomain proteins and single-domain proteins. Subdomain folding also provides a rationale for the complex kinetics often observed.

  3. Stochastic Resonance in Protein Folding Dynamics.

    PubMed

    Davtyan, Aram; Platkov, Max; Gruebele, Martin; Papoian, Garegin A

    2016-05-04

    Although protein folding reactions are usually studied under static external conditions, it is likely that proteins fold in a locally fluctuating cellular environment in vivo. To mimic such behavior in in vitro experiments, the local temperature of the solvent can be modulated either harmonically or using correlated noise. In this study, coarse-grained molecular simulations are used to investigate these possibilities, and it is found that both periodic and correlated random fluctuations of the environment can indeed accelerate folding kinetics if the characteristic frequencies of the applied fluctuations are commensurate with the internal timescale of the folding reaction; this is consistent with the phenomenon of stochastic resonance observed in many other condensed-matter processes. To test this theoretical prediction, the folding dynamics of phosphoglycerate kinase under harmonic temperature fluctuations are experimentally probed using Förster resonance energy transfer fluorescence measurements. To analyze these experiments, a combination of theoretical approaches is developed, including stochastic simulations of folding kinetics and an analytical mean-field kinetic theory. The experimental observations are consistent with the theoretical predictions of stochastic resonance in phosphoglycerate kinase folding. When combined with an alternative experiment on the protein VlsE using a power spectrum analysis, elaborated in Dave et al., ChemPhysChem 2016, 10.1002/cphc.201501041, the overall data overwhelmingly point to the experimental confirmation of stochastic resonance in protein folding dynamics.

  4. Protein folding: When ribosomes pick the structure

    NASA Astrophysics Data System (ADS)

    Sivertsson, Elin M.; Itzhaki, Laura S.

    2014-05-01

    Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.

  5. Local vs global motions in protein folding

    PubMed Central

    Maisuradze, Gia G.; Liwo, Adam; Senet, Patrick; Scheraga, Harold A.

    2013-01-01

    It is of interest to know whether local fluctuations in a polypeptide chain play any role in the mechanism by which the chain folds to the native structure of a protein. This question is addressed by analyzing folding and non-folding trajectories of a protein; as an example, the analysis is applied to the 37-residue triple β-strand WW domain from the Formin binding protein 28 (FBP28) (PDB ID: 1E0L). Molecular dynamics (MD) trajectories were generated with the coarse-grained united-residue force field, and one- and two-dimensional free-energy landscapes (FELs) along the backbone virtual-bond angle θ and backbone virtual-bond-dihedral angle γ of each residue, and principal components, respectively, were analyzed. The key residues involved in the folding of the FBP28 WW domain are elucidated by this analysis. The correlations between local and global motions are found. It is shown that most of the residues in the folding trajectories of the system studied here move in a concerted fashion, following the dynamics of the whole system. This demonstrates how the choice of a pathway has to involve concerted movements in order for this protein to fold. This finding also sheds light on the effectiveness of principal component analysis (PCA) for the description of the folding dynamics of the system studied. It is demonstrated that the FEL along the PCs, computed by considering only several critically-placed residues, can correctly describe the folding dynamics. PMID:23914144

  6. Folding and Finding RNA Secondary Structure

    PubMed Central

    Mathews, David H.; Moss, Walter N.; Turner, Douglas H.

    2010-01-01

    SUMMARY Optimal exploitation of the expanding database of sequences requires rapid finding and folding of RNAs. Methods are reviewed that automate folding and discovery of RNAs with algorithms that couple thermodynamics with chemical mapping, NMR, and/or sequence comparison. New functional noncoding RNAs in genome sequences can be found by combining sequence comparison with the assumption that functional noncoding RNAs will have more favorable folding free energies than other RNAs. When a new RNA is discovered, experiments and sequence comparison can restrict folding space so that secondary structure can be rapidly determined with the help of predicted free energies. In turn, secondary structure restricts folding in three dimensions, which allows modeling of three-dimensional structure. An example from a domain of a retrotransposon is described. Discovery of new RNAs and their structures will provide insights into evolution, biology, and design of therapeutics. Applications to studies of evolution are also reviewed. PMID:20685845

  7. Fan-fold shielded electrical leads

    DOEpatents

    Rohatgi, Rajeev R.; Cowan, Thomas E.

    1996-01-01

    Fan-folded electrical leads made from copper cladded Kapton, for example, with the copper cladding on one side serving as a ground plane and the copper cladding on the other side being etched to form the leads. The Kapton is fan folded with the leads located at the bottom of the fan-folds. Electrical connections are made by partially opening the folds of the fan and soldering, for example, the connections directly to the ground plane and/or the lead. The fan folded arrangement produces a number of advantages, such as electrically shielding the leads from the environment, is totally non-magnetic, and has a very low thermal conductivity, while being easy to fabricate.

  8. Cooperative Tertiary Interaction Network Guides RNA Folding

    SciTech Connect

    Behrouzi, Reza; Roh, Joon Ho; Kilburn, Duncan; Briber, R.M.; Woodson, Sarah A.

    2013-04-08

    Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we mutated the major tertiary interactions in a group I ribozyme by single-base substitutions. The resulting perturbations to the folding energy landscape were measured using SAXS, ribozyme activity, hydroxyl radical footprinting, and native PAGE. Double- and triple-mutant cycles show that most tertiary interactions have a small effect on the stability of the native state. Instead, the formation of core and peripheral structural motifs is cooperatively linked in near-native folding intermediates, and this cooperativity depends on the native helix orientation. The emergence of a cooperative interaction network at an early stage of folding suppresses nonnative structures and guides the search for the native state. We suggest that cooperativity in noncoding RNAs arose from natural selection of architectures conducive to forming a unique, stable fold.

  9. Fan-fold shielded electrical leads

    DOEpatents

    Rohatgi, R.R.; Cowan, T.E.

    1996-06-11

    Disclosed are fan-folded electrical leads made from copper cladded Kapton, for example, with the copper cladding on one side serving as a ground plane and the copper cladding on the other side being etched to form the leads. The Kapton is fan folded with the leads located at the bottom of the fan-folds. Electrical connections are made by partially opening the folds of the fan and soldering, for example, the connections directly to the ground plane and/or the lead. The fan folded arrangement produces a number of advantages, such as electrically shielding the leads from the environment, is totally non-magnetic, and has a very low thermal conductivity, while being easy to fabricate. 3 figs.

  10. The origami of thioredoxin-like folds

    PubMed Central

    Pan, Jonathan L.; Bardwell, James C.A.

    2006-01-01

    Origami is the Japanese art of folding a piece of paper into complex shapes and forms. Much like origami of paper, Nature has used conserved protein folds to engineer proteins for a particular task. An example of a protein family, which has been used by Nature numerous times, is the thioredoxin superfamily. Proteins in the thioredoxin superfamily are all structured with a β-sheet core surrounded with α-helices, and most contain a canonical CXXC motif. The remarkable feature of these proteins is that the link between them is the fold; however, their reactivity is different for each member due to small variations in this general fold as well as their active site. This review attempts to unravel the minute differences within this protein family, and it also demonstrates the ingenuity of Nature to use a conserved fold to generate a diverse collection of proteins to perform a number of different biochemical tasks. PMID:17008712

  11. Expansion of the Role of Population Education Called for at the Regional Consultative Seminar.

    ERIC Educational Resources Information Center

    Population Education Newsletter and Forum, 1986

    1986-01-01

    Provides an overview of the deliberations, issues, and recommendations that occurred during a seminar on population education in Bangkok in 1986. Identifies specific actions that need to be taken in educational programs in Asia and in the Pacific. (ML)

  12. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  13. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  14. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  15. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  16. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  17. 34 CFR 664.11 - What is a short-term seminar project?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... short-term seminar project is— (a) Designed to help integrate international studies into an institution's or school system's general curriculum; and (b) Normally four to six weeks in length and focuses...

  18. Women's Education and Empowerment. Report of the International Seminar (Hamburg, Germany, January 27-February 2, 1993).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Hamburg (Germany). Inst. for Education.

    These proceedings contain the following papers: "The International Seminar on Women's Empowerment" (Anonuevo, Bochynek); "The Theoretical and Practical Bases for Empowerment" (Stromquist); "Some Reflections on the Empowerment of Women" (Lazo); "Women's Literacy and Empowerment: The Nellore Experience"…

  19. Seminar on the Associated Schools: N'Djamena, Chad, 4-6 May 1982.

    ERIC Educational Resources Information Center

    International Understanding at School, 1982

    1982-01-01

    Recommendations of a seminar held in N'Djamena, Chad, from May 4-6, 1982, to support the activities of the Associated Schools project intended to promote international understanding and peace are described. (RM)

  20. Distant Echo of a Strong Voice: Reflections on Margaret Mead's Evaluation of the Salzburg Seminar.

    ERIC Educational Resources Information Center

    Patton, Michael Quinn

    2003-01-01

    Comments on the evaluation by Margaret Mead of the first Salzburg Seminar (1947). Notes the strength and clarity of Mead's evaluation report, which was written without the aid of the many tools on which today's evaluators draw. (SLD)

  1. From student to emergency nurse: a qualitative study of an educational support seminar.

    PubMed

    Turner, Nancy; Goudreau, Johanne

    2011-01-01

    The purpose of this qualitative study was to document the transition experience of new nursing graduates who participated in an educational support seminar during their first year of emergency room (ER) practice. Study participants reported that the seminar provided learning and nurturing that facilitated their integration into the ER team, influenced their decision to stay in the ER, and grounded the process of their professionalization. Important considerations regarding education, professionalization, and leadership emerged.

  2. East Africa seminar and workshop of remote sensing of natural resources and environment

    USGS Publications Warehouse

    Deutsch, Morris

    1975-01-01

    Report on total program covering East Africa Seminar and Workshop on remote sensing of natural resources and the environment held in Nairobi, Kenya, March 21 April 3, 1974, attended by participants from 10 English-speaking African nations. Appendices are included for Seminar proceedings, workshop lectures and outlines, field trip reports and critiques by participants, and reports on potential applications of an operational earth resources satellite for the participating countries.

  3. Report on the Dagstuhl Seminar on Visualization and Monitoring of Network Traffic

    SciTech Connect

    Keim, Daniel; Pras, Aiko; Schonwalder, Jurgen; Wong, Pak C.; Mansmann, Florian

    2011-01-26

    The Dagstuhl Seminar on Visualization and Monitoring of Network Traffic [1] took place May 17-20, 2009 in Dagstuhl, Germany. Dagstuhl seminars promote personal interaction and open discussion of results as well as new ideas. Unlike at most conferences, the focus is not solely on the presentation of established results but to equal parts on results, ideas, sketches, and open problems. The aim of this particular seminar was to bring together experts from the information visualization community and the networking community in order to discuss the state of the art of monitoring and visualization of network traffic. People from the different research communities involved jointly organized the seminar. The co-chairs of the seminar from the networking community were Aiko Pras (University of Twente) and Jürgen Schönwälder (Jacobs University Bremen). The co-chairs from the visualization community were Daniel A. Keim (University of Konstanz) and Pak Chung Wong (Pacific Northwest National Lab). Florian Mansmann (University of Konstanz) helped with producing this report. The seminar was organized and supported by Schloss Dagstuhl and the EC IST-EMANICS Network of Excellence [1].

  4. FOREWORD: International Scientific Seminars on "Fundamental and Applied Problems of Photonics and Condensed Matter Physics"

    NASA Astrophysics Data System (ADS)

    Yurchenko, Stanislav; Ryzhii, Viktor

    2015-01-01

    International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics'' were held in Bauman Moscow State Technical University (BMSTU) in May - June 2014. The idea of the Seminars was to organize a series of meetings between young scientists and discuss actual problems and the latest results in Photonics and Condensed Matter Physics. There were eight Sessions: Modern Problems of Condensed Matter Physics; Laser Physics; Spectroscopy of Condensed Matter; Terahertz Optical Technology; Optical Signals Processing; Physics of Optical Strong Correlated Systems; Complex Dusty Plasma Physics; Biomediacal Applications of Photonics. Seminars were organized by the young group of scientists and students from Research and Educational Center ''Photonics and Infrared Technology'' at BMSTU. It brought a significant contribution to the development of youth science in the field of Physics and Photonics in Russia. More than 100 young scientists and students participated in the Seminars in spring - summer 2014. The International Scientific Seminars were supported by the Russian Foundation for Basic Research (grant # 14-08-06030-g). This volume contains proceedings of the International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics''. Stanislav Yurchenko and Viktor Ryzhii Bauman Moscow State Technical University

  5. Quantification of a Helical Origami Fold

    NASA Astrophysics Data System (ADS)

    Dai, Eric; Han, Xiaomin; Chen, Zi

    2015-03-01

    Origami, the Japanese art of paper folding, is traditionally viewed as an amusing pastime and medium of artistic expression. However, in recent years, origami has served as a source of inspiration for innovations in science and engineering. Here, we present the geometric and mechanical properties of a twisting origami fold. The origami structure created by the fold exhibits several interesting properties, including rigid foldibility, local bistability and finely tunable helical coiling, with control over pitch, radius and handedness of the helix. In addition, the pattern generated by the fold closely mimics the twist buckling patterns shown by thin materials, for example, a mobius strip. We use six parameters of the twisting origami pattern to generate a fully tunable graphical model of the fold. Finally, we present a mathematical model of the local bistability of the twisting origami fold. Our study elucidates the mechanisms behind the helical coiling and local bistability of the twisting origami fold, with potential applications in robotics and deployable structures. Acknowledgment to Branco Weiss Fellowship for funding.

  6. GroEL-mediated protein folding.

    PubMed Central

    Fenton, W. A.; Horwich, A. L.

    1997-01-01

    I. Architecture of GroEL and GroES and the reaction pathway A. Architecture of the chaperonins B. Reaction pathway of GroEL-GroES-mediated folding II. Polypeptide binding A. A parallel network of chaperones binding polypeptides in vivo B. Polypeptide binding in vitro 1. Role of hydrophobicity in recognition 2. Homologous proteins with differing recognition-differences in primary structure versus effects on folding pathway 3. Conformations recognized by GroEL a. Refolding studies b. Binding of metastable intermediates c. Conformations while stably bound at GroEL 4. Binding constants and rates of association 5. Conformational changes in the substrate protein associated with binding by GroEL a. Observations b. Kinetic versus thermodynamic action of GroEL in mediating unfolding c. Crossing the energy landscape in the presence of GroEL III. ATP binding and hydrolysis-driving the reaction cycle IV. GroEL-GroES-polypeptide ternary complexes-the folding-active cis complex A. Cis and trans ternary complexes B. Symmetric complexes C. The folding-active intermediate of a chaperonin reaction-cis ternary complex D. The role of the cis space in the folding reaction E. Folding governed by a "timer" mechanism F. Release of nonnative polypeptides during the GroEL-GroES reaction G. Release of both native and nonnative forms under physiologic conditions H. A role for ATP binding, as well as hydrolysis, in the folding cycle V. Concluding remarks. PMID:9098884

  7. Cooperativity and modularity in protein folding

    PubMed Central

    Sasai, Masaki; Chikenji, George; Terada, Tomoki P.

    2016-01-01

    A simple statistical mechanical model proposed by Wako and Saitô has explained the aspects of protein folding surprisingly well. This model was systematically applied to multiple proteins by Muñoz and Eaton and has since been referred to as the Wako-Saitô-Muñoz-Eaton (WSME) model. The success of the WSME model in explaining the folding of many proteins has verified the hypothesis that the folding is dominated by native interactions, which makes the energy landscape globally biased toward native conformation. Using the WSME and other related models, Saitô emphasized the importance of the hierarchical pathway in protein folding; folding starts with the creation of contiguous segments having a native-like configuration and proceeds as growth and coalescence of these segments. The Φ-values calculated for barnase with the WSME model suggested that segments contributing to the folding nucleus are similar to the structural modules defined by the pattern of native atomic contacts. The WSME model was extended to explain folding of multi-domain proteins having a complex topology, which opened the way to comprehensively understanding the folding process of multi-domain proteins. The WSME model was also extended to describe allosteric transitions, indicating that the allosteric structural movement does not occur as a deterministic sequential change between two conformations but as a stochastic diffusive motion over the dynamically changing energy landscape. Statistical mechanical viewpoint on folding, as highlighted by the WSME model, has been renovated in the context of modern methods and ideas, and will continue to provide insights on equilibrium and dynamical features of proteins.

  8. Folding pathways of the Tetrahymena ribozyme

    PubMed Central

    Mitchell, David; Russell, Rick

    2014-01-01

    Like many structured RNAs, the Tetrahymena group I intron ribozyme folds through multiple pathways and intermediates. Under standard conditions in vitro, a small fraction reaches the native state (N) with kobs ≈ 0.6 min–1, while the remainder forms a long-lived misfolded conformation (M) thought to differ in topology. These alternative outcomes reflect a pathway that branches late in folding, after disruption of a trapped intermediate (Itrap). Here, we use catalytic activity to probe the folding transitions from Itrap to the native and misfolded states. We show that mutations predicted to weaken the core helix P3 do not increase the rate of folding from Itrap but they increase the fraction that reaches the native state rather than forming the misfolded state. Thus, P3 is disrupted during folding to the native state but not to the misfolded state, and P3 disruption occurs after the rate-limiting step. Interestingly, P3-strengthening mutants also increase native folding. Additional experiments show that these mutants are rapidly committed to folding to the native state, although they reach the native state with approximately the same rate constant as the wild-type ribozyme (~1 min–1). Thus, the P3-strengthening mutants populate a distinct pathway that includes at least one intermediate but avoids the M state, most likely because P3 and the correct topology are formed early. Our results highlight multiple pathways in RNA folding and illustrate how kinetic competitions between rapid events can have long-lasting effects because the ‘choice’ is enforced by energy barriers that grow larger as folding progresses. PMID:24747051

  9. A bidirectional shape memory alloy folding actuator

    NASA Astrophysics Data System (ADS)

    Paik, Jamie K.; Wood, Robert J.

    2012-06-01

    This paper presents a low-profile bidirectional folding actuator based on annealed shape memory alloy sheets applicable for meso- and microscale systems. Despite the advantages of shape memory alloys—high strain, silent operation, and mechanical simplicity—their application is often limited to unidirectional operation. We present a bidirectional folding actuator that produces two opposing 180° motions. A laser-patterned nickel alloy (Inconel 600) heater localizes actuation to the folding sections. The actuator has a thin ( < 1 mm) profile, making it appropriate for use in robotic origami. Various design parameters and fabrication variants are described and experimentally explored in the actuator prototype.

  10. Network measures for protein folding state discrimination

    PubMed Central

    Menichetti, Giulia; Fariselli, Piero; Remondini, Daniel

    2016-01-01

    Proteins fold using a two-state or multi-state kinetic mechanisms, but up to now there is not a first-principle model to explain this different behavior. We exploit the network properties of protein structures by introducing novel observables to address the problem of classifying the different types of folding kinetics. These observables display a plain physical meaning, in terms of vibrational modes, possible configurations compatible with the native protein structure, and folding cooperativity. The relevance of these observables is supported by a classification performance up to 90%, even with simple classifiers such as discriminant analysis. PMID:27464796

  11. Mechanical Models of Fault-Related Folding

    SciTech Connect

    Johnson, A. M.

    2003-01-09

    The subject of the proposed research is fault-related folding and ground deformation. The results are relevant to oil-producing structures throughout the world, to understanding of damage that has been observed along and near earthquake ruptures, and to earthquake-producing structures in California and other tectonically-active areas. The objectives of the proposed research were to provide both a unified, mechanical infrastructure for studies of fault-related foldings and to present the results in computer programs that have graphical users interfaces (GUIs) so that structural geologists and geophysicists can model a wide variety of fault-related folds (FaRFs).

  12. Geometric formalism for DNA quadruplex folding.

    PubMed

    Webba da Silva, Mateus

    2007-01-01

    Understanding the control of self-assembly and stereochemical properties of DNA higher order architectural folds is of fundamental importance in biology as well as biochemical technological applications. Guanine-rich DNA sequences can form tetrahelical architectures termed quadruplexes. A formalism is presented describing the interdependency of a set of structural descriptors as a geometric basis for folding of unimolecular quadruplex topologies. It represents a standard for interpretation of structural characteristics of quadruplexes, and is comprehensive in explicitly harmonizing the results of published literature with a unified language. The formalism is a fundamental step towards prediction of unimolecular quadruplex folding topologies from primary sequence.

  13. Comparison of the folded stripline and stacked stripline concepts to the folded waveguide launcher

    SciTech Connect

    Gardner, W.L.; Caughman, J.B.O.; Hoffman, D.J.; Probert, P.H.

    1993-12-31

    Two new concepts are being developed as possible upgrades to the folded waveguide launcher. The folded stripline is a folded waveguide with an additional conductor positioned inside. The term stripline refers to the resemblance of the design to microwave microstrip line. The conductor provides support for TEM mode propagation, which eliminates cutoff and the nonlinear frequency dependence of the waveguide impedance and phase velocity. A natural extension to the folded stripline is the stacked stripline, which comprises several stacked, independent TEM waveguides. Initial measurements indicate that both concepts have better magnetic flux coupling than the folded waveguide.

  14. Comparison of the folded stripline and stacked stripline concepts to the folded waveguide launcher

    SciTech Connect

    Gardner, W.L.; Caughman, J.B.O.; Hoffman, D.J. ); Probert, P.H. )

    1994-10-15

    Two new concepts are being developed as possible upgrades to the folded waveguide launcher. The folded stripline is a folded waveguide with an additional conductor positioned inside. The term [ital stripline] refers to the resemblance of the design to microwave microstrip line. The conductor provides support for TEM mode propagation, which eliminates cutoff and the nonlinear frequency dependence of the waveguide impedance and phase velocity. A natural extension to the folded stripline is the stacked stripline, which comprises several stacked, independent TEM waveguides. Initial measurements indicate that both concepts have better magnetic flux coupling than the folded waveguide.

  15. Topology Explains Why Automobile Sunshades Fold Oddly

    ERIC Educational Resources Information Center

    Feist, Curtis; Naimi, Ramin

    2009-01-01

    Automobile sunshades always fold into an "odd" number of loops. The explanation why involves elementary topology (braid theory and linking number, both explained in detail here with definitions and examples), and an elementary fact from algebra about symmetric group.

  16. Cycle 22 COS/NUV Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, T.; Welty, A.

    2016-09-01

    We summarize the Cycle 22 COS/NUV Fold Distribution for the Cosmic Origins Spectrograph's (COS) MAMA detector on the Hubble Space Telescope. The detector micro-channel plate's health state is determined and the results are presented.

  17. Folded Resonant Horns for Power Ultrasonic Applications

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Askins, Stephen; Gradziel, Michael; Bao, Xiaoqi; Chang, Zensheu; Dolgin, Benjamin; Bar-Cohen, Yoseph; Peterson, Tom

    2003-01-01

    Folded horns have been conceived as alternatives to straight horns used as resonators and strain amplifiers in power ultrasonic systems. Such systems are used for cleaning, welding, soldering, cutting, and drilling in a variety of industries. In addition, several previous NASA Tech Briefs articles have described instrumented drilling, coring, and burrowing machines that utilize combinations of sonic and ultrasonic vibrational actuation. The main advantage of a folded horn, relative to a straight horn of the same resonance frequency, is that the folded horn can be made shorter (that is, its greatest linear dimension measured from the outside can be made smaller). Alternatively, for a given length, the resonance frequency can be reduced. Hence, the folded-horn concept affords an additional degree of design freedom for reducing the length of an ultrasonic power system that includes a horn.

  18. Folding, Binding, Misfolding and Aggregation with AWSEM

    NASA Astrophysics Data System (ADS)

    Schafer, Nicholas P.

    This thesis discusses our recent results using the Associative-memory, Water-mediated, Structure and Energy Model (AWSEM), an optimized, coarse-grained molecular dynamics protein folding model, to fold, bind, and predict the misfolding behavior of proteins. AWSEM is capable of performing de novo structure prediction on small alpha-helical protein domains and predict the binding interfaces of homo- and hetero-dimers. More recent work demonstrates how the misfolding behavior of tandem constructs in AWSEM is consistent with crucial aspects of ensemble and single molecule experiments on the aggregation and misfolding of these constructs. The first chapter is a review of the energy landscape theory of protein folding as it applies to the problem of protein structure prediction, and more specifically how energy landscape theory and the principle of minimal frustration can be used to optimize parameters of coarse-grained protein folding simulation models. The subsequent four chapters are reports of novel research performed with one such model.

  19. Self-folding miniature elastic electric devices

    NASA Astrophysics Data System (ADS)

    Miyashita, Shuhei; Meeker, Laura; Tolley, Michael T.; Wood, Robert J.; Rus, Daniela

    2014-09-01

    Printing functional materials represents a considerable impact on the access to manufacturing technology. In this paper we present a methodology and validation of print-and-self-fold miniature electric devices. Polyvinyl chloride laminated sheets based on metalized polyester film show reliable self-folding processes under a heat application, and it configures 3D electric devices. We exemplify this technique by fabricating fundamental electric devices, namely a resistor, capacitor, and inductor. Namely, we show the development of a self-folded stretchable resistor, variable resistor, capacitive strain sensor, and an actuation mechanism consisting of a folded contractible solenoid coil. Because of their pre-defined kinematic design, these devices feature elasticity, making them suitable as sensors and actuators in flexible circuits. Finally, an RLC circuit obtained from the integration of developed devices is demonstrated, in which the coil based actuator is controlled by reading a capacitive strain sensor.

  20. Origami: Paper Folding--The Algorithmic Way.

    ERIC Educational Resources Information Center

    Heukerott, Pamela Beth

    1988-01-01

    Describes origami, the oriental art of paper folding as an activity to teach upper elementary students concepts and skills in geometry involving polygons, angles, measurement, symmetry, and congruence. (PK)

  1. Frustration in Condensed Matter and Protein Folding

    NASA Astrophysics Data System (ADS)

    Li, Z.; Tanner, S.; Conroy, B.; Owens, F.; Tran, M. M.; Boekema, C.

    2014-03-01

    By means of computer modeling, we are studying frustration in condensed matter and protein folding, including the influence of temperature and Thomson-figure formation. Frustration is due to competing interactions in a disordered state. The key issue is how the particles interact to reach the lowest frustration. The relaxation for frustration is mostly a power function (randomly assigned pattern) or an exponential function (regular patterns like Thomson figures). For the atomic Thomson model, frustration is predicted to decrease with the formation of Thomson figures at zero kelvin. We attempt to apply our frustration modeling to protein folding and dynamics. We investigate the homogeneous protein frustration that would cause the speed of the protein folding to increase. Increase of protein frustration (where frustration and hydrophobicity interplay with protein folding) may lead to a protein mutation. Research is supported by WiSE@SJSU and AFC San Jose.

  2. The Ribosome Modulates Nascent Protein Folding

    PubMed Central

    Kaiser, Christian M.; Goldman, Daniel H.; Chodera, John D.; Tinoco, Ignacio; Bustamante, Carlos

    2014-01-01

    Proteins are synthesized by the ribosome and generally must fold to become functionally active. Although it is commonly assumed that the ribosome affects the folding process, this idea has been extremely difficult to demonstrate. We have developed an experimental system to investigate the folding of single ribosome-bound stalled nascent polypeptides with optical tweezers. In T4 lysozyme, synthesized in a reconstituted in vitro translation system, the ribosome slows the formation of stable tertiary interactions and the attainment of the native state relative to the free protein. Incomplete T4 lysozyme polypeptides misfold and aggregate when free in solution, but they remain folding-competent near the ribosomal surface. Altogether, our results suggest that the ribosome not only decodes the genetic information and synthesizes polypeptides, but also promotes efficient de novo attainment of the native state. PMID:22194581

  3. Statistical properties of a folded elastic rod

    NASA Astrophysics Data System (ADS)

    Bayart, Elsa; Deboeuf, Stéphanie; Boué, Laurent; Corson, Francis; Boudaoud, Arezki; Adda-Bedia, Mokhtar

    2010-03-01

    A large variety of elastic structures naturally seem to be confined into environments too small to accommodate them; the geometry of folded structures span a wide range of length-scales. The elastic properties of these confined systems are further constrained by self-avoidance as well as by the dimensionality of both structures and container. To mimic crumpled paper, we devised an experimental setup to study the packing of a dimensional elastic object in 2D geometries: an elastic rod is folded at the center of a circular Hele-Shaw cell by a centripetal force. The initial configuration of the rod and the acceleration of the rotating disk allow to span different final folded configurations while the final rotation speed controls the packing intensity. Using image analysis we measure geometrical and mechanical properties of the folded configurations, focusing on length, curvature and energy distributions.

  4. Under-folded proteins: Conformational ensembles and their roles in protein folding, function, and pathogenesis.

    PubMed

    Uversky, Vladimir N

    2013-11-01

    For decades, protein function was intimately linked to the presence of a unique, aperiodic crystal-like structure in a functional protein. The two only places for conformational ensembles of under-folded (or partially folded) protein forms in this picture were either the end points of the protein denaturation processes or transiently populated folding intermediates. Recent years witnessed dramatic change in this perception and conformational ensembles, which the under-folded proteins are, have moved from the shadow. Accumulated to date data suggest that a protein can exist in at least three global forms-functional and folded, functional and intrinsically disordered (nonfolded), and nonfunctional and misfolded/aggregated. Under-folded protein states are crucial for each of these forms, serving as important folding intermediates of ordered proteins, or as functional states of intrinsically disordered proteins (IDPs) and IDP regions (IDPRs), or as pathology triggers of misfolded proteins. Based on these observations, conformational ensembles of under-folded proteins can be classified as transient (folding and misfolding intermediates) and permanent (IDPs and stable misfolded proteins). Permanently under-folded proteins can further be split into intentionally designed (IDPs and IDPRs) and unintentionally designed (misfolded proteins). Although intrinsic flexibility, dynamics, and pliability are crucial for all under-folded proteins, the different categories of under-foldedness are differently encoded in protein amino acid sequences.

  5. FOLD PROFILER: A MATLAB ®—based program for fold shape classification

    NASA Astrophysics Data System (ADS)

    Lisle, R. J.; Fernández Martínez, J. L.; Bobillo-Ares, N.; Menéndez, O.; Aller, J.; Bastida, F.

    2006-02-01

    FOLD PROFILER is a MATLAB code for classifying the shapes of profiles of folded surfaces. The classification is based on the comparison of the natural fold profile with curves representing mathematical functions. The user is offered a choice of four methods, each based on a different type of function: cubic Bezier curves, conic sections, power functions and superellipses. The comparison is carried out by the visual matching of the fold profile displayed on-screen from an imported digital image and computed theoretical curves which are superimposed on the image of the fold. To improve the fit with the real fold shape, the parameters of the theoretical curves are changed by simple mouse actions. The parameters of the mathematical function that best fits the real folds are used to classify the fold shape. FOLD PROFILER allows the rapid implementation of four existing methods for fold shape analysis. The attractiveness of this analytical tool lies in the way it gives an instant visual appreciation of the effect of changing the parameters that are used to classify fold geometry.

  6. Folding funnels, binding funnels, and protein function.

    PubMed Central

    Tsai, C. J.; Kumar, S.; Ma, B.; Nussinov, R.

    1999-01-01

    Folding funnels have been the focus of considerable attention during the last few years. These have mostly been discussed in the general context of the theory of protein folding. Here we extend the utility of the concept of folding funnels, relating them to biological mechanisms and function. In particular, here we describe the shape of the funnels in light of protein synthesis and folding; flexibility, conformational diversity, and binding mechanisms; and the associated binding funnels, illustrating the multiple routes and the range of complexed conformers. Specifically, the walls of the folding funnels, their crevices, and bumps are related to the complexity of protein folding, and hence to sequential vs. nonsequential folding. Whereas the former is more frequently observed in eukaryotic proteins, where the rate of protein synthesis is slower, the latter is more frequent in prokaryotes, with faster translation rates. The bottoms of the funnels reflect the extent of the flexibility of the proteins. Rugged floors imply a range of conformational isomers, which may be close on the energy landscape. Rather than undergoing an induced fit binding mechanism, the conformational ensembles around the rugged bottoms argue that the conformers, which are most complementary to the ligand, will bind to it with the equilibrium shifting in their favor. Furthermore, depending on the extent of the ruggedness, or of the smoothness with only a few minima, we may infer nonspecific, broad range vs. specific binding. In particular, folding and binding are similar processes, with similar underlying principles. Hence, the shape of the folding funnel of the monomer enables making reasonable guesses regarding the shape of the corresponding binding funnel. Proteins having a broad range of binding, such as proteolytic enzymes or relatively nonspecific endonucleases, may be expected to have not only rugged floors in their folding funnels, but their binding funnels will also behave similarly

  7. The hydrogen exchange core and protein folding.

    PubMed Central

    Li, R.; Woodward, C.

    1999-01-01

    A database of hydrogen-deuterium exchange results has been compiled for proteins for which there are published rates of out-exchange in the native state, protection against exchange during folding, and out-exchange in partially folded forms. The question of whether the slow exchange core is the folding core (Woodward C, 1993, Trends Biochem Sci 18:359-360) is reexamined in a detailed comparison of the specific amide protons (NHs) and the elements of secondary structure on which they are located. For each pulsed exchange or competition experiment, probe NHs are shown explicitly; the large number and broad distribution of probe NHs support the validity of comparing out-exchange with pulsed-exchange/competition experiments. There is a strong tendency for the same elements of secondary structure to carry NHs most protected in the native state, NHs first protected during folding, and NHs most protected in partially folded species. There is not a one-to-one correspondence of individual NHs. Proteins for which there are published data for native state out-exchange and theta values are also reviewed. The elements of secondary structure containing the slowest exchanging NHs in native proteins tend to contain side chains with high theta values or be connected to a turn/loop with high theta values. A definition for a protein core is proposed, and the implications for protein folding are discussed. Apparently, during folding and in the native state, nonlocal interactions between core sequences are favored more than other possible nonlocal interactions. Other studies of partially folded bovine pancreatic trypsin inhibitor (Barbar E, Barany G, Woodward C, 1995, Biochemistry 34:11423-11434; Barber E, Hare M, Daragan V, Barany G, Woodward C, 1998, Biochemistry 37:7822-7833), suggest that developing cores have site-specific energy barriers between microstates, one disordered, and the other(s) more ordered. PMID:10452602

  8. [Congenital retinal folds in different clinical cases].

    PubMed

    Munteanu, M

    2005-01-01

    We present 12 clinical cases of congenital retinal folds with different etiologies: posterior primitive vitreous persistency and hyperplasia (7 cases),retinocytoma (1 case). retinopathy of prematurity (1 case), astrocytoma of the retina (1 case), retinal vasculitis (1 case), Goldmann-Favre syndrome (1 case). Etiopathogenic and nosological aspects are discussed; the congenital retinal folds are interpreted as a symptom in a context of a congenital or acquired vitreo-retinal pathology.

  9. Geometric Folding Algorithms: Bridging Theory to Practice

    DTIC Science & Technology

    2009-11-03

    Proved that any orthogonal polyhedron can be folded from a single, universal crease pattern (box pleating). 1.2 Origami Design • Developed...mathematical theory for what happens in paper between creases, in partic- ular for the case of circular creases. • Circular crease origami on permanent...sheet of paper. • Developing mathematical theory of Robert Lang’s TreeMaker framework for efficiently folding tree-shaped origami "bases

  10. Protein folding and misfolding: mechanism and principles.

    PubMed

    Englander, S Walter; Mayne, Leland; Krishna, Mallela M G

    2007-11-01

    Two fundamentally different views of how proteins fold are now being debated. Do proteins fold through multiple unpredictable routes directed only by the energetically downhill nature of the folding landscape or do they fold through specific intermediates in a defined pathway that systematically puts predetermined pieces of the target native protein into place? It has now become possible to determine the structure of protein folding intermediates, evaluate their equilibrium and kinetic parameters, and establish their pathway relationships. Results obtained for many proteins have serendipitously revealed a new dimension of protein structure. Cooperative structural units of the native protein, called foldons, unfold and refold repeatedly even under native conditions. Much evidence obtained by hydrogen exchange and other methods now indicates that cooperative foldon units and not individual amino acids account for the unit steps in protein folding pathways. The formation of foldons and their ordered pathway assembly systematically puts native-like foldon building blocks into place, guided by a sequential stabilization mechanism in which prior native-like structure templates the formation of incoming foldons with complementary structure. Thus the same propensities and interactions that specify the final native state, encoded in the amino-acid sequence of every protein, determine the pathway for getting there. Experimental observations that have been interpreted differently, in terms of multiple independent pathways, appear to be due to chance misfolding errors that cause different population fractions to block at different pathway points, populate different pathway intermediates, and fold at different rates. This paper summarizes the experimental basis for these three determining principles and their consequences. Cooperative native-like foldon units and the sequential stabilization process together generate predetermined stepwise pathways. Optional misfolding errors

  11. Optimum folding pathways for growing protein chains.

    PubMed

    Senturk, Serife; Baday, Sefer; Arkun, Yaman; Erman, Burak

    2007-11-26

    The folding of a protein is studied as it grows residue by residue from the N-terminus and enters an environment that stabilizes the folded state. This mode of folding of a growing chain is different from refolding where the full chain folds from a disordered initial configuration to the native state. We propose a sequential dynamic optimization method that computes the evolution of optimum folding pathways as amino acid residues are added to the peptide chain one by one. The dynamic optimization formulation is deterministic and uses Newton's equations of motion and a Go-type potential that establishes the native contacts and excluded volume effects. The method predicts the optimal energy-minimizing path among all the alternative feasible pathways. As two examples, the folding of the chicken villin headpiece, a 36-residue protein, and chymotrypsin inhibitor 2 (CI2), a 64-residue protein, are studied. Results on the villin headpiece show significant differences from the refolding of the same chain studied previously. Results on CI2 mostly agree with the results of refolding experiments and computational work.

  12. Cortical Folding Patterns and Predicting Cytoarchitecture

    PubMed Central

    Rajendran, Niranjini; Busa, Evelina; Augustinack, Jean; Hinds, Oliver; Yeo, B.T. Thomas; Mohlberg, Hartmut; Amunts, Katrin; Zilles, Karl

    2008-01-01

    The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to perform ad hoc estimations of the locations of the BAs, little is understood regarding 1) how variable the position of a given BA is with respect to the folds, 2) whether the location of some BAs is more variable than others, and 3) whether the variability is related to the level of a BA in a putative cortical hierarchy. We use whole-brain histology of 10 postmortem human brains and surface-based analysis to test how well the folds predict the locations of the BAs. We show that higher order cortical areas exhibit more variability than primary and secondary areas and that the folds are much better predictors of the BAs than had been previously thought. These results further highlight the significance of cortical folding patterns and suggest a common mechanism for the development of the folds and the cytoarchitectonic fields. PMID:18079129

  13. "Wet" Versus "Dry" Folding of Polyproline

    NASA Astrophysics Data System (ADS)

    Shi, Liuqing; Holliday, Alison E.; Bohrer, Brian C.; Kim, Doyong; Servage, Kelly A.; Russell, David H.; Clemmer, David E.

    2016-06-01

    When the all- cis polyproline-I helix (PPI, favored in 1-propanol) of polyproline-13 is introduced into water, it folds into the all- trans polyproline-II (PPII) helix through at least six intermediates [Shi, L., Holliday, A.E., Shi, H., Zhu, F., Ewing, M.A., Russell, D.H., Clemmer, D.E.: Characterizing intermediates along the transition from PPI to PPII using ion mobility-mass spectrometry. J. Am. Chem. Soc. 136, 12702-12711 (2014)]. Here, we show that the solvent-free intermediates refold into the all- cis PPI helix with high (>90%) efficiency. Moreover, in the absence of solvent, each intermediate appears to utilize the same small set of pathways observed for the solution-phase PPII → PPI transition upon immersion of PPIIaq in 1-propanol. That folding in solution (under conditions where water is displaced by propanol) and folding in vacuo (where energy required for folding is provided by collisional activation) occur along the same pathway is remarkable. Implicit in this statement is that 1-propanol mimics a "dry" environment, similar to the gas phase. We note that intermediates with structures that are similar to PPIIaq can form PPII under the most gentle activation conditions—indicating that some transitions observed in water (i.e. , "we t" folding, are accessible (albeit inefficient) in vacuo. Lastly, these "dry" folding experiments show that PPI (all cis) is favored under "dry" conditions, which underscores the role of water as the major factor promoting preference for trans proline.

  14. Folding of non-Euclidean curved shells

    NASA Astrophysics Data System (ADS)

    Bende, Nakul; Evans, Arthur; Innes-Gold, Sarah; Marin, Luis; Cohen, Itai; Santangelo, Christian; Hayward, Ryan

    2015-03-01

    Origami-based folding of 2D sheets has been of recent interest for a variety of applications ranging from deployable structures to self-folding robots. Though folding of planar sheets follows well-established principles, folding of curved shells involves an added level of complexity due to the inherent influence of curvature on mechanics. In this study, we use principles from differential geometry and thin shell mechanics to establish fundamental rules that govern folding of prototypical creased shells. In particular, we show how the normal curvature of a crease line controls whether the deformation is smooth or discontinuous, and investigate the influence of shell thickness and boundary conditions. We show that snap-folding of shells provides a route to rapid actuation on time-scales dictated by the speed of sound. The simple geometric design principles developed can be applied at any length-scale, offering potential for bio-inspired soft actuators for tunable optics, microfluidics, and robotics. This work was funded by the National Science Foundation through EFRI ODISSEI-1240441 with additional support to S.I.-G. through the UMass MRSEC DMR-0820506 REU program.

  15. The Story of a Seminar in Applied Communication. The Dag Hammarskjold Seminar on "Communication--An Essential Component in Development Work" (Uppsala, Sweden, August 27-September 9, 1972).

    ERIC Educational Resources Information Center

    Fuglesang, Andreas, Ed.

    The objective of the two week long 1972 Dag Hammarskjold Seminar was to break away from traditional and theoretical concepts of information work in order to gain a practical insight into communication, especially as it applies to social and economic development. Fifty participants and lecturers from developed and developing countries in Europe and…

  16. Discipline-Based Art Education and Cultural Diversity. Seminar Proceedings of a National Invitational Seminar (3rd, Austin Texas, August 6-9, 1992).

    ERIC Educational Resources Information Center

    Getty Center for Education in the Arts, Los Angeles, CA.

    This publication contains proceedings of a seminar structured around five basic themes: (1) cultural diversity in education; (2) discipline based art education (DBAE) and cultural diversity; (3) how cultural diversity has affected practices in art history, aesthetics, criticism, and art making; (4) experiences in other disciplines which effect…

  17. Changes & Challenges: Hot Topics in a New Era of Schools. Proceedings of the Education Law Association Winter Seminar (Park City, UT, March 15-18, 2001). Seminar Outlines.

    ERIC Educational Resources Information Center

    Education Law Association, Dayton, OH.

    The following are outlines presented by individuals at the Education Law Association 2001 winter seminar: "Academic Freedom and the Religiously Affiliated University" (the freedom to teach, research, and publish has never been--and still is not--without limits); "How Random and Suspicionless May School Searches Be" (random and suspicionless drug…

  18. Creativity in English: Papers Relating to the Anglo-American Seminar on the Teaching of English (Dartmouth College, New Hampshire, 1966). The Dartmouth Seminar Papers.

    ERIC Educational Resources Information Center

    Summerfield, Geoffrey, Ed.

    Creativity and its development in students through creative English programs are the subjects of this report from the Dartmouth Seminar. David Holbrook's paper, "Creativity in the English Programme," maintains that English should be taught creatively to enhance the child's capacity to deal with his inner and outer experiences and to help…

  19. Response to Literature: Papers Relating to the Anglo-American Seminar on the Teaching of English (Dartmouth College, New Hampshire, 1966). The Dartmouth Seminar Papers.

    ERIC Educational Resources Information Center

    Squire, James R., Ed.

    The encouragement and formulation of a student's imaginative response to and "engagement" with literature and the concerns of the papers and summaries of discussions in this Dartmouth Seminar report. James Britton discusses refining the student's natural response to literature by developing his increased sense of form ("principally…

  20. THE USES OF MYTH, PAPERS RELATING TO THE ANGLO-AMERICAN SEMINAR ON THE TEACHING OF ENGLISH (DARTMOUTH COLLEGE, NEW HAMPSHIRE, 1966). THE DARTMOUTH SEMINAR PAPERS.

    ERIC Educational Resources Information Center

    OLSON, PAUL A., ED.

    THE USES OF MYTH, ITS RELATION TO TRANSLATION, AND THE RELATION OF BOTH TO THE TEACHING OF ENGLISH FORM THE SUBJECTS OF THIS DARTMOUTH SEMINAR STUDY-GROUP REPORT. PAUL OLSON'S INTRODUCTION ON THE BASIC ISSUES OF DEFINITION AND SYSTEMATIC INTERPRETATION IS FOLLOWED BY THE POSITION PAPER, "SOME MEANINGS AND USES OF MYTH" BY ALBERT LAVIN,…

  1. DRAMA IN THE ENGLISH CLASSROOM, PAPERS RELATING TO THE ANGLO-AMERICAN SEMINAR ON THE TEACHING OF ENGLISH (DARTMOUTH COLLEGE, NEW HAMPSHIRE, 1966). THE DARTMOUTH SEMINAR PAPERS.

    ERIC Educational Resources Information Center

    BARNES, DOUGLAS, ED.

    THIS DISCUSSION OF DRAMA, DRAWN FROM PAPERS AND IDEAS PRESENTED AT THE DARTMOUTH ANGLO-AMERICAN SEMINAR ON THE TEACHING OF ENGLISH, EMPHASIZES THE NEED FOR DRAMATIC ACTIVITIES AND PRESENTS METHODS OF EFFECTIVELY TEACHING DRAMA IN THE SECONDARY CLASSROOM. THE FIRST CHAPTER EXPLORES THE TYPE OF EDUCATION MOST EFFECTIVE FOR A STUDENT LIVING IN A…

  2. Projektarbejde i fremmedsprogene: Rapport fra seminar pa Roskilde Universitetscenter (Project Work in Foreign Languages: Report from a Seminar at Roskilde University Center). ROLIG-papir 38.

    ERIC Educational Resources Information Center

    Jakobsen, Karen Sonne, Ed.

    This report describes a seminar at Roskilde University Center (Denmark) on project work in foreign languages, which brought together language teachers and theorists from different schools, including universities, business schools, technical schools, merchants schools, and high schools, to discuss their experiences with project work in foreign…

  3. Proceedings of the Towards Competency Seminar. A Seminar on Curriculum Development and Evaluation in Vocational Education in New Zealand (Wellington, New Zealand, August 30-31, 1988).

    ERIC Educational Resources Information Center

    Wagner, Graham, Ed.

    These proceedings begin with opening remarks that discuss seminar concerns and objectives. These remarks define two concerns: (1) evaluation of the methods of curriculum development and evaluation appropriate for vocational education in New Zealand; and (2) development of guidelines to assist educators to meet the requirements for competency-based…

  4. A seminar on gardens for the health of the skin.

    PubMed

    Ryan, Terence J; Matts, Paul J; Snyder, Brad; Orr, Vanya

    2014-05-01

    This is a report on a seminar held on January 12, 2013, at the Regional Dermatology Training Centre in Tanzania, sponsored by the International Society of Dermatology as part of its Taskforce Program for Skin Care for All: Community Dermatology. There were four themes: (i) Gardens attached to health centers increase their attractiveness and result in increased attendance and, thus, increase the utilization of effective skin care interventions. Literature on the positive effect of greenery surrounding health centers on health and the environment is reviewed. (ii) Adding an expert on agriculture to the staff of health centers in Rwanda has provided nutrition and safe medicines. (iii) In southern India, these interventions are channeled through the empowerment of tribal women in an area noted for anxiety due to unemployment in the tea and forestry industry. The gardens are used for teaching about nutrition and herbal medicines, and the women are further attracted by childcare facilities. (iv) Measuring barrier function defects gives early warning of malnutrition of the skin after damage by trauma or by ultraviolet radiation. Higher cost research techniques may help to provide the science required to produce its evidence base. In conclusion, Gardens for health should be adopted as policy by skin care providers.

  5. Proceedings of the joint Russian-American hydrogeology seminar

    SciTech Connect

    Tsang, C.F.; Mironenko, V.; Pozdniakov, S.

    1997-12-31

    Hydrogeology research has been very active in both Russia and the US because of the concerns for migration of radioactive and chemical contaminants in soils and geologic formations, as well as for water problems related to mining and other industrial operations. Russian hydrogeologists have developed various analysis and field testing techniques, sometimes in parallel with US counterparts. These Proceedings come out of a Seminar held to bring together a small group (about 15) of active Russian researchers in geologic flow and transport associated with the disposal of radioactive and chemical wastes either on the soils or through deep injection wells, with a corresponding group (about 25) of American hydrogeologists. The meeting was intentionally kept small to enable informal, detailed and in-depth discussions on hydrogeological issues of common interest. Out of this interaction, the authors hope that, firstly, they will have learned from each other and secondly, that research collaborations will be established where there is the opportunity. This proceedings presents the summaries and viewgraphs from the presentations. What cannot be conveyed here is the warm and cooperative atmosphere of these interactions, both inside and outside the formal sessions, which may well lead to future collaborations.

  6. Advancing Successful Physics Majors - The Physics First Year Seminar Experience

    NASA Astrophysics Data System (ADS)

    Deibel, Jason; Petkie, Douglas

    In 2012, the Wright State University physics curriculum introduced a new year-long seminar course required for all new physics majors. The goal of this course is to improve student retention and success via building a community of physics majors and provide them with the skills, mindset, and advising necessary to successfully complete a degree and transition to the next part of their careers. This new course sequence assembles a new cohort of majors annually. To prepare each cohort, students engage in a variety of activities that span from student success skills to more specific physics content while building an entrepreneurial mindset. Students participate in activities including study skills, career night, course planning, campus services, and a department social function. More importantly, students gain exposure to programming, literature searches, data analysis, technical writing, elevator pitches, and experimental design via hands-on projects. This includes the students proposing, designing, and conducting their own experiments. Preliminary evidence indicates increased retention, student success, and an enhanced sense of community among physics undergraduate students, The overall number of majors and students eventually completing their physics degrees has nearly tripled. Associate Professor, Department of Physics.

  7. Dual folding pathways of an α /β protein from all-atom ab initio folding simulations

    NASA Astrophysics Data System (ADS)

    Lei, Hongxing; Wang, Zhi-Xiang; Wu, Chun; Duan, Yong

    2009-10-01

    Successful ab initio folding of proteins with both α-helix and β-sheet requires a delicate balance among a variety of forces in the simulation model, which may explain that the successful folding of any α /β proteins to within experimental error has yet to be reported. Here we demonstrate that it is an achievable goal to fold α /β proteins with a force field emphasizing the balance between the two major secondary structures. Using our newly developed force field, we conducted extensive ab initio folding simulations on an α /β protein full sequence design (FSD) employing both conventional molecular dynamics and replica exchange molecular dynamics in combination with a generalized-Born solvation model. In these simulations, the folding of FSD to the native state with high population (>64.2%) and high fidelity (Cα-Root Mean Square Deviation of 1.29 Å for the most sampled conformation when compared to the experimental structure) was achieved. The folding of FSD was found to follow two pathways. In the major pathway, the folding started from the formation of the helix. In the minor pathway, however, folding of the β-hairpin started first. Further examination revealed that the helix initiated from the C-terminus and propagated toward the N-terminus. The formation of the hydrophobic contacts coincided with the global folding. Therefore the hydrophobic force does not appear to be the driving force of the folding of this protein.

  8. Cross folding in southern Bighorn basin

    SciTech Connect

    Gubbels, T.L.

    1986-08-01

    Analysis of Landsat Thematic Mapper imagery coupled with surface structural investigations of well-exposed folds in the southern Bighorn basin have revealed two northwest-trending folds that have been refolded. The eastern boundary of the Owl Creek Mountains is characterized by a well-defined alignment of folds that extend north-northwest from the Owl Creek thrust front. Bridger monocline, Wildhorse Butte anticline, and Red Hole anticline lie along this trend. Initial Laramide folding, probably during latest Cretaceous time, resulted in a single, continuous, north-northwest-trending anticline with a southwestward vergence. This anticline was progressively unfolded from south to north as the Owl Creek Range was thrust southward over the Wind River basin in earliest Eocene time; scissors-like vertical motion along this flexure rotated the axial surface of the early formed Bridger anticline, resulting in a monocline with a reversed vergence (northeastward). Formation of the Thermopolis/East Warm Springs anticline parallel to the north flank of the range accompanied thrusting and effectively refolded the northern end of the Wildhorse Butte anticline along an east-west axis. Faulting of the oversteepened south limb of the Red Hole cross fold was contemporaneous with folding. Cross-cutting fold axes in this area and the Mud Creek area to the west are best explained by a counterclockwise change in stress direction during the latest phase of the Laramide orogeny. Vertical movement along the eastern side of the Owl Creek Range results from differential motion in the hanging wall of the crystalline thrust sheet.

  9. The nature of protein folding pathways

    PubMed Central

    Englander, S. Walter; Mayne, Leland

    2014-01-01

    How do proteins fold, and why do they fold in that way? This Perspective integrates earlier and more recent advances over the 50-y history of the protein folding problem, emphasizing unambiguously clear structural information. Experimental results show that, contrary to prior belief, proteins are multistate rather than two-state objects. They are composed of separately cooperative foldon building blocks that can be seen to repeatedly unfold and refold as units even under native conditions. Similarly, foldons are lost as units when proteins are destabilized to produce partially unfolded equilibrium molten globules. In kinetic folding, the inherently cooperative nature of foldons predisposes the thermally driven amino acid-level search to form an initial foldon and subsequent foldons in later assisted searches. The small size of foldon units, ∼20 residues, resolves the Levinthal time-scale search problem. These microscopic-level search processes can be identified with the disordered multitrack search envisioned in the “new view” model for protein folding. Emergent macroscopic foldon–foldon interactions then collectively provide the structural guidance and free energy bias for the ordered addition of foldons in a stepwise pathway that sequentially builds the native protein. These conclusions reconcile the seemingly opposed new view and defined pathway models; the two models account for different stages of the protein folding process. Additionally, these observations answer the “how” and the “why” questions. The protein folding pathway depends on the same foldon units and foldon–foldon interactions that construct the native structure. PMID:25326421

  10. Folding at the birth of the nascent chain: coordinating translation with co-translational folding.

    PubMed

    Zhang, Gong; Ignatova, Zoya

    2011-02-01

    In the living cells, the folding of many proteins is largely believed to begin co-translationally, during their biosynthesis at the ribosomes. In the ribosomal tunnel, the nascent peptide may establish local interactions and stabilize α-helical structures. Long-range contacts are more likely outside the ribosomes after release of larger segments of the nascent chain. Examples suggest that domains can attain native-like structure on the ribosome with and without population of folding intermediates. The co-translational folding is limited by the speed of the gradual extrusion of the nascent peptide which imposes conformational restraints on its folding landscape. Recent experimental and in silico modeling studies indicate that translation kinetics fine-tunes co-translational folding by providing a time delay for sequential folding of distinct portions of the nascent chain.

  11. Petrofabric test of viscous folding theory

    NASA Astrophysics Data System (ADS)

    Onasch, Charles M.

    1984-06-01

    Compression and extension axes are deduced from quartz deformation lamellae in a quartzite and a graywacke folded into an asymetrical syncline. Deformation lamellae fabrics in the two sandstones are distinctly different. In the graywacke, regardless of bedding orientation or position on the fold, compression axes are normal or nearly normal to the axial planar rough cleavage. Extension axes generally lie in the cleavage plane, parallel to dip. In most quartzite samples, compression axes are parallel or subparallel to bedding, at high angles to the fold axis and extension axes are normal to bedding. Two samples from the very base of the formation indicate compression parallel to the fold axis with extension parallel to bedding, at high angles to the fold axis. One of these two shows both patterns. The lamellae fabric geometry in these two samples suggests the presence of a neutral surface in the quartzite. The lamellae-derived compression and extension axes are in good agreement with the buckling behavior of a viscous layer (quartzite) embedded in a less viscous medium (graywacke and shale below and shale and carbonate above).

  12. Computational and theoretical methods for protein folding.

    PubMed

    Compiani, Mario; Capriotti, Emidio

    2013-12-03

    A computational approach is essential whenever the complexity of the process under study is such that direct theoretical or experimental approaches are not viable. This is the case for protein folding, for which a significant amount of data are being collected. This paper reports on the essential role of in silico methods and the unprecedented interplay of computational and theoretical approaches, which is a defining point of the interdisciplinary investigations of the protein folding process. Besides giving an overview of the available computational methods and tools, we argue that computation plays not merely an ancillary role but has a more constructive function in that computational work may precede theory and experiments. More precisely, computation can provide the primary conceptual clues to inspire subsequent theoretical and experimental work even in a case where no preexisting evidence or theoretical frameworks are available. This is cogently manifested in the application of machine learning methods to come to grips with the folding dynamics. These close relationships suggested complementing the review of computational methods within the appropriate theoretical context to provide a self-contained outlook of the basic concepts that have converged into a unified description of folding and have grown in a synergic relationship with their computational counterpart. Finally, the advantages and limitations of current computational methodologies are discussed to show how the smart analysis of large amounts of data and the development of more effective algorithms can improve our understanding of protein folding.

  13. Visualizing chaperone-assisted protein folding

    PubMed Central

    Horowitz, Scott; Salmon, Loïc; Koldewey, Philipp; Ahlstrom, Logan S.; Martin, Raoul; Quan, Shu; Afonine, Pavel V.; van den Bedem, Henry; Wang, Lili; Xu, Qingping; Trievel, Raymond C.; Brooks, Charles L.; Bardwell, James CA

    2016-01-01

    Challenges in determining the structures of heterogeneous and dynamic protein complexes have greatly hampered past efforts to obtain a mechanistic understanding of many important biological processes. One such process is chaperone-assisted protein folding, where obtaining structural ensembles of chaperone:substrate complexes would ultimately reveal how chaperones help proteins fold into their native state. To address this problem, we devised a novel structural biology approach based on X-ray crystallography, termed Residual Electron and Anomalous Density (READ). READ enabled us to visualize even sparsely populated conformations of the substrate protein immunity protein 7 (Im7) in complex with the E. coli chaperone Spy. This study resulted in a series of snapshots depicting the various folding states of Im7 while bound to Spy. The ensemble shows that Spy-associated Im7 samples conformations ranging from unfolded to partially folded and native-like states, and reveals how a substrate can explore its folding landscape while bound to a chaperone. PMID:27239796

  14. Protein Folding and Mechanisms of Proteostasis

    PubMed Central

    Díaz-Villanueva, José Fernando; Díaz-Molina, Raúl; García-González, Victor

    2015-01-01

    Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious cell processes. Therefore in recent years the etiology of a great number of diseases has been attributed to failures in mechanisms that modulate protein structure. Interconnections among metabolic and cell signaling pathways are critical for homeostasis to converge on mechanisms associated with protein folding as well as for the preservation of the native structure of proteins. For instance, imbalances in secretory protein synthesis pathways lead to a condition known as endoplasmic reticulum (ER) stress which elicits the adaptive unfolded protein response (UPR). Therefore, taking this into consideration, a key part of this paper is developed around the protein folding phenomenon, and cellular mechanisms which support this pivotal condition. We provide an overview of chaperone protein function, UPR via, spatial compartmentalization of protein folding, proteasome role, autophagy, as well as the intertwining between these processes. Several diseases are known to have a molecular etiology in the malfunction of mechanisms responsible for protein folding and in the shielding of native structure, phenomena which ultimately lead to misfolded protein accumulation. This review centers on our current knowledge about pathways that modulate protein folding, and cell responses involved in protein homeostasis. PMID:26225966

  15. A sweet code for glycoprotein folding.

    PubMed

    Caramelo, Julio J; Parodi, Armando J

    2015-11-14

    Glycoprotein synthesis is initiated in the endoplasmic reticulum (ER) lumen upon transfer of a glycan (Glc3Man9GlcNAc2) from a lipid derivative to Asn residues (N-glycosylation). N-Glycan-dependent quality control of glycoprotein folding in the ER prevents exit to Golgi of folding intermediates, irreparably misfolded glycoproteins and incompletely assembled multimeric complexes. It also enhances folding efficiency by preventing aggregation and facilitating formation of proper disulfide bonds. The control mechanism essentially involves four components, resident lectin-chaperones (calnexin and calreticulin) that recognize monoglucosylated polymannose protein-linked glycans, lectin-associated oxidoreductase acting on monoglucosylated glycoproteins (ERp57), a glucosyltransferase that creates monoglucosylated epitopes in protein-linked glycans (UGGT) and a glucosidase (GII) that removes the glucose units added by UGGT. This last enzyme is the only mechanism component sensing glycoprotein conformations as it creates monoglucosylated glycans exclusively in not properly folded glycoproteins or in not completely assembled multimeric glycoprotein complexes. Glycoproteins that fail to properly fold are eventually driven to proteasomal degradation in the cytosol following the ER-associated degradation pathway, in which the extent of N-glycan demannosylation by ER mannosidases play a relevant role in the identification of irreparably misfolded glycoproteins.

  16. Proteopedia: Rossmann Fold: A Beta-Alpha-Beta Fold at Dinucleotide Binding Sites

    ERIC Educational Resources Information Center

    Hanukoglu, Israel

    2015-01-01

    The Rossmann fold is one of the most common and widely distributed super-secondary structures. It is composed of a series of alternating beta strand (ß) and alpha helical (a) segments wherein the ß-strands are hydrogen bonded forming a ß-sheet. The initial beta-alpha-beta (ßaß) fold is the most conserved segment of Rossmann folds. As this segment…

  17. Palaeomagnetic analysis of plunging fold structures: Errors and a simple fold test

    NASA Astrophysics Data System (ADS)

    Stewart, Simon A.

    1995-02-01

    The conventional corrections for bedding dip in palaeomagnetic studies involve either untilting about strike or about some inclined axis—the choice is usually governed by the perceived fold hinge orientation. While it has been recognised that untilting bedding about strike can be erroneous if the beds lie within plunging fold structures, there are several types of fold which have plunging hinges, but whose limbs have rotated about horizontal axes. Examples are interference structures and forced folds; restoration about inclined axes may be incorrect in these cases. The angular errors imposed upon palaeomagnetic lineation data via the wrong choice of rotation axis during unfolding are calculated here and presented for lineations in any orientation which could be associated with an upright, symmetrical fold. This extends to palaeomagnetic data previous analyses which were relevant to bedding-parallel lineations. This numerical analysis highlights the influence of various parameters which describe fold geometry and relative lineation orientation upon the angular error imparted to lineation data by the wrong unfolding method. The effect of each parameter is described, and the interaction of the parameters in producing the final error is discussed. Structural and palaeomagnetic data are cited from two field examples of fold structures which illustrate the alternative kinematic histories. Both are from thin-skinned thrust belts, but the data show that one is a true plunging fold, formed by rotation about its inclined hinge, whereas the other is an interference structure produced by rotation of the limbs about non-parallel horizontal axes. Since the angle between the palaeomagnetic lineations and the inclined fold hinge is equal on both limbs in the former type of structure, but varies from limb to limb in the latter, a simple test can be defined which uses palaeomagnetic lineation data to identify rotation axes and hence fold type. This test can use pre- or syn-folding

  18. Proceedings of the Advanced Seminar on one-dimensional, open-channel Flow and transport modeling

    USGS Publications Warehouse

    Schaffranek, Raymond W.

    1989-01-01

    In view of the increased use of mathematical/numerical simulation models, of the diversity of both model investigations and informational project objectives, and of the technical demands of complex model applications by U.S. Geological Survey personnel, an advanced seminar on one-dimensional open-channel flow and transport modeling was organized and held on June 15-18, 1987, at the National Space Technology Laboratory, Bay St. Louis, Mississippi. Principal emphasis in the Seminar was on one-dimensional flow and transport model-implementation techniques, operational practices, and application considerations. The purposes of the Seminar were to provide a forum for the exchange of information, knowledge, and experience among model users, as well as to identify immediate and future needs with respect to model development and enhancement, user support, training requirements, and technology transfer. The Seminar program consisted of a mix of topical and project presentations by Geological Survey personnel. This report is a compilation of short papers that summarize the presentations made at the Seminar.

  19. Assessing Outcomes and Perceived Benefits of a Professional Development Seminar Series

    PubMed Central

    Zueger, Patrick M.; Katz, Norman L.

    2014-01-01

    Objective. To evaluate the outcomes of alumni who were enrolled in a professional development seminar series during their doctor of pharmacy program. Design. A weekly development seminar series was administered over 5 semesters with the goal of bringing academic advisees together to help develop performance-based abilities, prepare them for entry into the profession after graduation, and provide exposure to different career opportunities. Assessment. A survey instrument containing 39 Likert-type scale items, 2 open-ended questions, and a 10-item demographic survey was created and content-validated to assess the effect of the seminar series on alumni advisees’ perceived outcomes and professional development since their graduation. The survey was electronically forwarded to advisees from the graduating classes of 2005 to 2012, and response data was collected with Qualtrics, a web-based survey service. A total of 36 percent of alumni responded to the survey. Respondents cited exposure to career alternatives and opportunities, development of presentation and communication skills, networking, and the importance of advisor/mentor relationships as benefits of the seminar series. Conclusion. The professional development seminar series has demonstrated a positive impact on alumni advisees’ career development and professional outcomes, most notably relating to career path exposure, communication skills, and advisor/mentor relationships. PMID:25386015

  20. Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand.

    PubMed

    Chang, Yu-Chu; Oas, Terrence G

    2010-06-29

    Understanding the interconversion between thermodynamically distinguishable states present in a protein folding pathway provides not only the kinetics and energetics of protein folding but also insights into the functional roles of these states in biological systems. The protein component of the bacterial RNase P holoenzyme from Bacillus subtilis (P protein) was previously shown to be unfolded in the absence of its cognate RNA or other anionic ligands. P protein was used in this study as a model system to explore general features of intrinsically disordered protein (IDP) folding mechanisms. The use of trimethylamine N-oxide (TMAO), an osmolyte that stabilizes the unliganded folded form of the protein, enabled us to study the folding process of P protein in the absence of ligand. Transient stopped-flow kinetic traces at various final TMAO concentrations exhibited multiphasic kinetics. Equilibrium "cotitration" experiments were performed using both TMAO and urea during the titration to produce a urea-TMAO titration surface of P protein. Both kinetic and equilibrium studies show evidence of a previously undetected intermediate state in the P protein folding process. The intermediate state is significantly populated, and the folding rate constants are relatively slow compared to those of intrinsically folded proteins similar in size and topology. The experiments and analysis described serve as a useful example for mechanistic folding studies of other IDPs.

  1. Non-cylindrical fold growth in the Zagros fold and thrust belt (Kurdistan, NE-Iraq)

    NASA Astrophysics Data System (ADS)

    Bartl, Nikolaus; Bretis, Bernhard; Grasemann, Bernhard; Lockhart, Duncan

    2010-05-01

    The Zagros mountains extends over 1800 km from Kurdistan in N-Iraq to the Strait of Hormuz in Iran and is one of the world most promising regions for the future hydrocarbon exploration. The Zagros Mountains started to form as a result of the collision between the Eurasian and Arabian Plates, whose convergence began in the Late Cretaceous as part of the Alpine-Himalayan orogenic system. Geodetic and seismological data document that both plates are still converging and that the fold and thrust belt of the Zagros is actively growing. Extensive hydrocarbon exploration mainly focuses on the antiforms of this fold and thrust belt and therefore the growth history of the folds is of great importance. This work investigates by means of structural field work and quantitative geomorphological techniques the progressive fold growth of the Permam, Bana Bawi- and Safeen- Anticlines located in the NE of the city of Erbil in the Kurdistan region of Northern Iraq. This part of the Zagros fold and thrust belt belongs to the so-called Simply Folded Belt, which is dominated by gentle to open folding. Faults or fault related folds have only minor importance. The mechanical anisotropy of the formations consisting of a succession of relatively competent (massive dolomite and limestone) and incompetent (claystone and siltstone) sediments essentially controls the deformation pattern with open to gentle parallel folding of the competent layers and flexural flow folding of the incompetent layers. The characteristic wavelength of the fold trains is around 10 km. Due to faster erosion of the softer rock layers in the folded sequence, the more competent lithologies form sharp ridges with steeply sloping sides along the eroded flanks of the anticlines. Using an ASTER digital elevation model in combination with geological field data we quantified 250 drainage basins along the different limbs of the subcylindrical Permam, Bana Bawi- and Safeen- Anticlines. Geomorphological indices of the drainage

  2. Year-Round Education Dream and Reality. A Report of the National Seminar on Year-Round Education (7th, Denver, Colorado, May 11-14, 1975).

    ERIC Educational Resources Information Center

    National Council on Year-Round Education.

    This seminar report contains the speeches of the two featured speakers (Dr. Calvin M. Frazier and Dr. Charles E. Silberman), the seminar papers of nearly 90 presenters, and biographical information on the speakers and presenters. (IRT)

  3. Transversal Clifford gates on folded surface codes

    SciTech Connect

    Moussa, Jonathan E.

    2016-10-12

    Surface and color codes are two forms of topological quantum error correction in two spatial dimensions with complementary properties. Surface codes have lower-depth error detection circuits and well-developed decoders to interpret and correct errors, while color codes have transversal Clifford gates and better code efficiency in the number of physical qubits needed to achieve a given code distance. A formal equivalence exists between color codes and folded surface codes, but it does not guarantee the transferability of any of these favorable properties. However, the equivalence does imply the existence of constant-depth circuit implementations of logical Clifford gates on folded surface codes. We achieve and improve this result by constructing two families of folded surface codes with transversal Clifford gates. This construction is presented generally for qudits of any dimension. Lastly, the specific application of these codes to universal quantum computation based on qubit fusion is also discussed.

  4. Transversal Clifford gates on folded surface codes

    DOE PAGES

    Moussa, Jonathan E.

    2016-10-12

    Surface and color codes are two forms of topological quantum error correction in two spatial dimensions with complementary properties. Surface codes have lower-depth error detection circuits and well-developed decoders to interpret and correct errors, while color codes have transversal Clifford gates and better code efficiency in the number of physical qubits needed to achieve a given code distance. A formal equivalence exists between color codes and folded surface codes, but it does not guarantee the transferability of any of these favorable properties. However, the equivalence does imply the existence of constant-depth circuit implementations of logical Clifford gates on folded surfacemore » codes. We achieve and improve this result by constructing two families of folded surface codes with transversal Clifford gates. This construction is presented generally for qudits of any dimension. Lastly, the specific application of these codes to universal quantum computation based on qubit fusion is also discussed.« less

  5. Exact folded-band chaotic oscillator.

    PubMed

    Corron, Ned J; Blakely, Jonathan N

    2012-06-01

    An exactly solvable chaotic oscillator with folded-band dynamics is shown. The oscillator is a hybrid dynamical system containing a linear ordinary differential equation and a nonlinear switching condition. Bounded oscillations are provably chaotic, and successive waveform maxima yield a one-dimensional piecewise-linear return map with segments of both positive and negative slopes. Continuous-time dynamics exhibit a folded-band topology similar to Rössler's oscillator. An exact solution is written as a linear convolution of a fixed basis pulse and a discrete binary sequence, from which an equivalent symbolic dynamics is obtained. The folded-band topology is shown to be dependent on the symbol grammar.

  6. Thermal stability of idealized folded carbyne loops

    PubMed Central

    2013-01-01

    Self-unfolding items provide a practical convenience, wherein ring-like frames are contorted into a state of equilibrium and subsequently  pop up’ or deploy when perturbed from a folded structure. Can the same process be exploited at the molecular scale? At the limiting scale is a closed chain of single atoms, used here to investigate the limits of stability of such folded ring structures via full atomistic molecular dynamics. Carbyne is a one-dimensional carbon allotrope composed of sp-hybridized carbon atoms. Here, we explore the stability of idealized carbyne loops as a function of chain length, curvature, and temperature, and delineate an effective phase diagram between folded and unfolded states. We find that while overall curvature is reduced, in addition to torsional and self-adhesive energy barriers, a local increase in curvature results in the largest impedance to unfolding. PMID:24252156

  7. The early folding kinetics of apomyoglobin.

    PubMed Central

    Pappu, R. V.; Weaver, D. L.

    1998-01-01

    The folding pathway of apomyoglobin has been experimentally shown to have early kinetic intermediates involving the A, B, G, and H helices. The earliest detected kinetic events occur on a ns to micros time scale. We show that the early folding kinetics of apomyoglobin may be understood as the association of nascent helices through a network of diffusion-collision-coalescence steps G + H <--> GH + A <--> AGH + B <--> ABGH obtained by solving the diffusion-collision model in a chemical kinetics approximation. Our reproduction of the experimental results indicates that the model is a useful way to analyze folding data. One prediction from our fit is that the nascent A and H helices should be relatively more helix-like before coalescence than the other apomyoglobin helices. PMID:9521125

  8. Transversal Clifford gates on folded surface codes

    NASA Astrophysics Data System (ADS)

    Moussa, Jonathan E.

    2016-10-01

    Surface and color codes are two forms of topological quantum error correction in two spatial dimensions with complementary properties. Surface codes have lower-depth error detection circuits and well-developed decoders to interpret and correct errors, while color codes have transversal Clifford gates and better code efficiency in the number of physical qubits needed to achieve a given code distance. A formal equivalence exists between color codes and folded surface codes, but it does not guarantee the transferability of any of these favorable properties. However, the equivalence does imply the existence of constant-depth circuit implementations of logical Clifford gates on folded surface codes. We achieve and improve this result by constructing two families of folded surface codes with transversal Clifford gates. This construction is presented generally for qudits of any dimension. The specific application of these codes to universal quantum computation based on qubit fusion is also discussed.

  9. Microbial Manipulation of the Amyloid Fold

    PubMed Central

    DePas, William H.

    2012-01-01

    Microbial biofilms are encased in a protein, DNA and polysaccharide matrix that protects the community, promotes interactions with the environment, and helps cells to adhere together. The protein component of these matrices is often a remarkably stable, β-sheet-rich polymer called amyloid. Amyloids form ordered, self-templating fibers that are highly aggregative, making them a valuable biofilm component. Some eukaryotic proteins inappropriately adopt the amyloid fold and these misfolded protein aggregates disrupt normal cellular proteostasis, which can cause significant cytotoxicity. Indeed, until recently amyloids were considered solely the result of protein misfolding. However, research over the past decade has revealed how various organisms have capitalized on the amyloid fold by developing sophisticated biogenesis pathways that coordinate gene expression, protein folding, and secretion so that amyloid-related toxicities are minimized. How microbes manipulate amyloids, by augmenting their advantageous properties and by reducing their undesirable properties, will be the subject of this review. PMID:23108148

  10. Leadership Seminar 1989: Workforce 2000. Proceedings of the American Association of Community and Junior Colleges' and St. Petersburg Junior College's Annual Leadership Seminar (2nd, Grand Rapids, Michigan, October 26-27, 1989).

    ERIC Educational Resources Information Center

    Kuttler, Carl M., Jr.; And Others

    In October 1989, St. Petersburg Junior College and the American Association of Community and Junior Colleges sponsored a seminar on strategies that community and junior colleges can use in working with business and industry to meet America's future work force needs. The proceedings of the seminar contains the text of presentations by nine…

  11. Academic Reforms in the World: Situation and Perspective in the Massification Stage of Higher Education. Reports of the 1997 Six-Nation Higher Education Project Seminar (Hiroshima, Japan February 6-7, 1997). RIHE International Seminar Reports, No.10.

    ERIC Educational Resources Information Center

    Hiroshima Univ. (Japan). Research Inst. for Higher Education.

    This volume presents papers presented at an international seminar conducted as part of the Six Nation Education Research Project, a project identifying aspects of higher education that currently confront educational systems in all countries. A keynote address by Robert Zemsky, titled "Seminar on Post-Massification," examines trends in the United…

  12. Computational analysis of hydrogenated graphyne folding

    NASA Astrophysics Data System (ADS)

    Lenear, Christopher; Becton, Matthew; Wang, Xianqiao

    2016-02-01

    This letter employs molecular mechanics simulations to analyze the geometric changes of foreign-atom-doped graphyne. Simulation results show that higher the density of dopant and the greater area covered by the dopant correlates to a greater folding angle of the graphyne sheet. Compared to graphene, graphyne folding could prove to be more effective for various nanodevices based on its unique band gap, especially when doped, and its tunable interactions with and absorption of foreign molecules. Therefore, our findings may offer unique perspectives into the development of novel graphyne-based nanodevices and stimulate the community's research interest in graphene-related origami.

  13. FOLD LENS FLUX ANOMALIES: A GEOMETRIC APPROACH

    SciTech Connect

    Goldberg, David M.; Chessey, Mary K.; Harris, Wendy B.; Richards, Gordon T.

    2010-06-01

    We develop a new approach for studying flux anomalies in quadruply imaged fold lens systems. We show that in the absence of substructure, microlensing, or differential absorption, the expected flux ratios of a fold pair can be tightly constrained using only geometric arguments. We apply this technique to 11 known quadruple lens systems in the radio and infrared and compare our estimates to the Monte Carlo based results of Keeton et al. We show that a robust estimate for a flux ratio from a smoothly varying potential can be found, and at long wavelengths those lenses deviating from this ratio almost certainly contain significant substructure.

  14. Fold Lens Flux Anomalies: A Geometric Approach

    NASA Astrophysics Data System (ADS)

    Goldberg, David M.; Chessey, Mary K.; Harris, Wendy B.; Richards, Gordon T.

    2010-06-01

    We develop a new approach for studying flux anomalies in quadruply imaged fold lens systems. We show that in the absence of substructure, microlensing, or differential absorption, the expected flux ratios of a fold pair can be tightly constrained using only geometric arguments. We apply this technique to 11 known quadruple lens systems in the radio and infrared and compare our estimates to the Monte Carlo based results of Keeton et al. We show that a robust estimate for a flux ratio from a smoothly varying potential can be found, and at long wavelengths those lenses deviating from this ratio almost certainly contain significant substructure.

  15. Circular permutant GFP insertion folding reporters

    SciTech Connect

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2013-04-16

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  16. Circular permutant GFP insertion folding reporters

    DOEpatents

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2008-06-24

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  17. Circular permutant GFP insertion folding reporters

    DOEpatents

    Waldo, Geoffrey S; Cabantous, Stephanie

    2013-02-12

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  18. Circular permutant GFP insertion folding reporters

    DOEpatents

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2011-06-14

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  19. Intensive chemistry seminar, group ability composition, and students' achievement

    NASA Astrophysics Data System (ADS)

    Fakhreddine, Fatima Hassan

    Intensive Chemistry Seminar (ICS) is an optional, supplemental, honors-level program for chemistry and biochemistry majors. The program emphasizes academic excellence in a challenging yet supportive chemistry rich learning environment that brings together a community of freshmen sharing the same interests. At the heart of ICS are intensive discussion sessions where students work in small groups on worksheets of carefully chosen problems that are direct application of the concepts covered in the main general chemistry course. Central to the success of such learning environment are interactions among students. A key element affecting the depth of such interactions is the relative ability levels of group members. The main focus of this study is to investigate the relationship between. group ability composition and chemistry knowledge acquisition within the ICS sessions. However, the study also compares the achievement of the ICS students with achievement of the non-ICS students. Our data analyses show that chemistry knowledge acquisition within the ICS sessions was significantly enhanced when group members' selection occurred from a Zone of Proximal Development perspective. Our analyses show that students' attitude toward the ICS is overwhelmingly positive and that the benefits of the program extend beyond academic achievement. In practice, our significant results have important applications in college level, cooperative learning practices with objectives similar to those of ICS. Our results show that Vygotsky's ZPD theory seems to be very appropriate for the design and application of cooperative learning environments. Finally, the significant beneficial outcomes of the ICS program should strongly support its integration into the general chemistry I and II majors' sections curriculums.

  20. Research in Distance Education 1. Revised Papers from the Research in Distance Education Seminar (1st, Geelong, Victoria, Australia, 1989).

    ERIC Educational Resources Information Center

    Evans, Terry, Ed.

    This collection of 16 papers grew out of a seminar held in 1989 on Research in Distance Education (RIDE). The participants in the seminar and those whose papers are included here were searching for new research methodologies, broadening their research agendas, and putting the practice of distance education under scrutiny. The following papers are…

  1. West Meets East in Malaysia and Singapore. Participants' Papers. Fulbright-Hays Summer Seminars Abroad Program 1999 (Malaysia and Singapore).

    ERIC Educational Resources Information Center

    Malaysian-American Commission on Educational Exchange, Kuala Lumpur.

    These projects were completed by participants in the Fulbright-Hays summer seminar in Malaysia and Singapore in 1999. The participants represented various regions of the U.S. and different grade levels and subject areas. The seminar offered a comprehensive overview of how the people of Malaysia and Singapore live, work, and strive towards their…

  2. The Relevance of Student Seminars on Clinically Related Subjects in a Biochemistry Course for Medical and Nutrition Students

    ERIC Educational Resources Information Center

    Hermes-Lima, Marcelo; Muniz, Karinne C.; Coutinho, Iracema S.

    2002-01-01

    The aim of this study was to determine the value of a system of seminars on clinically related biochemistry topics for undergraduate students in medicine and nutrition at the University of Brasilia, Brazil. During the second semester of 1998 (1998-2), the teaching staff decided to establish new and stricter rules for the seminar method and to…

  3. Malaysia/Singapore: Where Asian Cultures Meet. Participants' Papers. Fulbright-Hays Seminars Abroad Program, 2001 (Malaysia and Singapore).

    ERIC Educational Resources Information Center

    Malaysian-American Commission on Educational Exchange, Kuala Lumpur.

    The general objective of the Fulbright-Hays Seminars Abroad Program is to help U.S. educators enhance their international understanding and increase their knowledge of the people and culture of other countries. This particular program offered participants an overview of life in Malaysia and Singapore through seminars and other activities.…

  4. Better Journals for the Library Profession. Report on a Seminar. (Montreal, Quebec, Canada, 30-31 August 1982).

    ERIC Educational Resources Information Center

    Borchardt, D. H.

    This report summarizes the proceedings of a seminar sponsored by the International Federation of Library Associations' (IFLA) Round Table of Editors of Library Journals (RTELJ) on the nature of library journals and on means of improving them. The emphasis of the seminar was on journal editing. Brief reviews are given of papers presented by seven…

  5. Determining the Relationship of Nursing Test Scores and Test Anxiety Levels before and after a Test-Taking Strategy Seminar.

    ERIC Educational Resources Information Center

    Carraway, Cassandra T.

    A study was conducted to determine whether participation in a test-taking strategy seminar significantly decreased test anxiety in first-year nursing students. The study also sought to compare nursing test scores of first-year nursing students who participated in the seminar with those who did not. The sample consisted of 30 first-year nursing…

  6. Biochemistry in an Undergraduate Writing-Intensive First-Year Program: Seminar Courses in Drugs and Bioethics

    ERIC Educational Resources Information Center

    Mills, Kenneth V.

    2015-01-01

    The College of the Holy Cross offers a universal first-year program called Montserrat, in which first-year students participate in a living-learning experience anchored by a yearlong seminar course. The seminar courses are part of a thematic cluster of four to eight courses; students in the cluster live together in a common dormitory and…

  7. Food/Hunger Macro-Analysis Seminar. A Do-It-Yourself Manual for College Courses and Action Groups.

    ERIC Educational Resources Information Center

    Moyer, William; Thorne, Erika

    This guide describes a fifteen-week macro-analysis seminar about food production, distribution, and consumption on international, national, and local levels. The macro-analysis approach emphasizes the interrelatedness of all parts of the food/hunger issue; therefore the seminar also addresses escalating military expenditures, widening poverty, and…

  8. Faculty Experience Teaching in an Interdisciplinary First-Year Seminar Program: The Case of the University of Guelph

    ERIC Educational Resources Information Center

    Murray, Jacqueline; Wolf, Peter

    2016-01-01

    First-year seminar programs have been a feature on the landscape of post-secondary teaching and learning in the United States, since they first appeared in the 1880s at Boston University (Mamrick, 2005). More recently, they have begun to appear at Canadian universities. For example, first-year seminars were introduced a decade ago at the…

  9. Army Management Views: Report of the 4th Biennial Management Instructors' Seminar July 21-26, 1968.

    ERIC Educational Resources Information Center

    Hancock, Chester H.; And Others

    The report of the Fourth Biennial Management Instructors' Seminar (July 21-26, 1968) which deals with the improvement of management education in the Army, contains presentations of guest speakers and reports of seminar workshops. The former presents the components of management -- planning, decision-making, productivity, communication, and…

  10. African Regional Seminar for Advanced Training In Systematic Curriculum Development and Evaluation. (Achimota, Ghana, 14 July--15 August 1975). Report.

    ERIC Educational Resources Information Center

    Swedish International Development Authority (SIDA).

    This report summarizes the African Regional Seminar for Advanced Training in Systematic Curriculum Development and Evaluation that was held at Achimota, Ghana, July 14-August 15 1975. Attending the seminar were 67 participants from 12 African countries, including Cameroon, Gambia, Ghana, Kenya, Liberia, Malawi, Nigeria, Sierra Leone, Swaziland,…

  11. Senior Seminar Focusing on Societal Issues Related to Chemistry and Biochemistry

    NASA Astrophysics Data System (ADS)

    White, Harold B., III; Johnston, Murray V.; Panar, Manuel

    2000-12-01

    The lack of a clearly defined content or structure provided the opportunity to transform a one-credit, pass-fail senior seminar course into a meaningful capstone experience for chemistry and biochemistry majors. In addition to individual and class exercises associated with employment, graduate school, communication skills, and professional ethics, small groups of students worked together to create informative Web sites that took positions on important societal issues related to chemistry. Each group presented a seminar and responded to questions from their peers and two or more unannounced visitors, "wild cards" who often had expertise in the seminar topic. Throughout the course, the instructors placed particular emphasis on developing students' ability to work cooperatively, locate and evaluate information, make informed judgments based on available information, and logically develop and defend their positions. Input from a retired industrial chemist helped define these skill elements.

  12. AME seminar program in the United States: genesis, goals, and cost-benefit reflections.

    PubMed

    Bradfield, J Y; Harris, J L

    1977-04-01

    The practicing physician's requirement for continuing postgraduate medical education is generally accepted and has generated a number of postgraduate education programs. In 1960, the FAA inaugurated a seminar program to serve the special educational needs of its approximately 7,500 designated Aviation Medical Examiners. These doctors, the majority of whom are civilian physicians representing almost every specialty, are charged with issuing or withholding the pilot's medical license to fly. Under the administration of coauthor Harris, the AME Seminar Program undergoes modification and change as improvements are suggested by accrued experience. Evaluation of data acquired from a variety of sources indicates that the AME does, in fact, need refresher training in civil aviation medicine. In helping fulfill that need, the AME Seminar Program is working effectively.

  13. An Innovative Seminar Course in Business Etiquette for Pharmacy Graduate Students

    PubMed Central

    2012-01-01

    Objectives. To develop and implement a seminar course for graduate students in the social and administrative pharmaceutical sciences to enhance knowledge and confidence with respect their abilities to demonstrate appropriate business etiquette. Design. A 1-credit graduate seminar course was designed based on learner-centered constructivist theory and application of Fink’s Taxonomy for Significant Learning. Assessment. Eleven students participated in the spring 2011 seminar course presentations and activities. Students completed pre- and post-assessment instruments, which included knowledge and attitudinal questions. Formative and summative assessments showed gains in student knowledge, perceived skills, and confidence based on observation and student-reported outcomes. Conclusion. Graduate student reaction to the course was overwhelmingly positive. The etiquette course has potential application in doctor of pharmacy education, other graduate disciplines, undergraduate education, and continuing professional development. PMID:23193341

  14. Regional Seminar on the Teacher Education Program Tryout at the SEAMEC Regional English Language Centre, Singapore, October 31 - November 2, 1968. Report.

    ERIC Educational Resources Information Center

    Regional English Center (Singapore).

    The regional seminar on the evaluation of the Teacher Education Program (TEP) tryout was held at the Regional English Language Center (RELC) in 1968. The seminar's purpose was to determine the usefulness of TEP in preparing teachers of English as a second language in the RELC member countries in Southeast Asia. This document is the seminar report.…

  15. National Survey of Freshman Seminar Programming, 1991. Helping First Year College Students Climb the Academic Ladder. The Freshman Year Experience: Monograph Series Number 10.

    ERIC Educational Resources Information Center

    Barefoot, Betsy O.; Fidler, Paul P.

    A national survey was conducted which examined the scope of freshman seminar programming, the characteristics of these seminars, and the variance between different types of freshman seminars with respect to their goals, topics addressed, and other characteristics. The study surveyed 2,460 regionally-accredited colleges and universities of whom…

  16. H TEXNH: Research Methods and Topics for the History of Rhetoric; Proceedings of the Speech Communication Association Doctoral Honors Seminar (2nd, Bloomington, Indiana, March 1979)

    ERIC Educational Resources Information Center

    Enos, Richard Leo, Ed.; Wiethoff, William E., Ed.

    The theme of the doctoral honors seminar reported here was the reappraisal of rhetorical research. After a preface and the seminar's keynote address about the ten negative commandments for the rhetorical historian, abstracts of seminar presentations are grouped under the headings rhetoric and culture, rhetoric and philosophy, and discourse…

  17. 2009 National Survey of First-Year Seminars: Ongoing Efforts to Support Students in Transition. Research Reports on College Transitions No. 2

    ERIC Educational Resources Information Center

    Padgett, Ryan D.; Keup, Jennifer R.

    2011-01-01

    Findings from the ninth triennial administration of the National Survey of First-Year Seminars, describing the nature and extent of first-year seminars on American college campuses. Drawn from a broad sample of colleges and universities from every institutional type, control, and size, the survey addresses topics including seminar characteristics…

  18. Topicality and the Structure of Interactive Talk in Face-to-Face Seminar Discussions: Implications for Research in Distributed Learning Media

    ERIC Educational Resources Information Center

    Gibson, Will; Hall, Andy; Callery, Peter

    2006-01-01

    This article examines the structure of topic movement within face-to-face postgraduate university seminar discussion forums through a conversation analytic approach. The analysis of 12 audio recordings of seminars showed that in spite of clear differences in the management style of sessions by seminar leaders there were important consistencies in…

  19. Understanding the role of the topology in protein folding by computational inverse folding experiments.

    PubMed

    Mucherino, Antonio; Costantini, Susan; di Serafino, Daniela; D'Apuzzo, Marco; Facchiano, Angelo; Colonna, Giovanni

    2008-08-01

    Recent studies suggest that protein folding should be revisited as the emergent property of a complex system and that the nature allows only a very limited number of folds that seem to be strongly influenced by geometrical properties. In this work we explore the principles underlying this new view and show how helical protein conformations can be obtained starting from simple geometric considerations. We generated a large data set of C-alpha traces made of 65 points, by computationally solving a backbone model that takes into account only topological features of the all-alpha proteins; then, we built corresponding tertiary structures, by using the sequences associated to the crystallographic structures of four small globular all-alpha proteins from PDB, and analysed them in terms of structural and energetic properties. In this way we obtained four poorly populated sets of structures that are reasonably similar to the conformational states typical of the experimental PDB structures. These results show that our computational approach can capture the native topology of all-alpha proteins; furthermore, it generates backbone folds without the influence of the side chains and uses the protein sequence to select a specific fold among the generated folds. This agrees with the recent view that the backbone plays an important role in the protein folding process and that the amino acid sequence chooses its own fold within a limited total number of folds.

  20. Hydroxyapatite surface-induced peptide folding.

    PubMed

    Capriotti, Lisa A; Beebe, Thomas P; Schneider, Joel P

    2007-04-25

    Herein, we describe the design and surface-binding characterization of a de novo designed peptide, JAK1, which undergoes surface-induced folding at the hydroxyapatite (HA)-solution interface. JAK1 is designed to be unstructured in buffered saline solution, yet undergo HA-induced folding that is largely governed by the periodic positioning of gamma-carboxyglutamic acid (Gla) residues within the primary sequence of the peptide. Circular dichroism (CD) spectroscopy and analytical ultracentrifugation indicate that the peptide remains unfolded and monomeric in solution under normal physiological conditions; however, CD spectroscopy indicates that in the presence of hydroxyapatite, the peptide avidly binds to the mineral surface adopting a helical structure. Adsorption isotherms indicate nearly quantitative surface coverage and Kd = 310 nM for the peptide-surface binding event. X-ray photoelectron spectroscopy (XPS) coupled with the adsorption isotherm data suggests that JAK1 binds to HA, forming a self-limiting monolayer. This study demonstrates the feasibility of using HA surfaces to trigger the intramolecular folding of designed peptides and represents the initial stages of defining the design rules that allow HA-induced peptide folding.

  1. Protein folded states are kinetic hubs

    PubMed Central

    Bowman, Gregory R.; Pande, Vijay S.

    2010-01-01

    Understanding molecular kinetics, and particularly protein folding, is a classic grand challenge in molecular biophysics. Network models, such as Markov state models (MSMs), are one potential solution to this problem. MSMs have recently yielded quantitative agreement with experimentally derived structures and folding rates for specific systems, leaving them positioned to potentially provide a deeper understanding of molecular kinetics that can lead to experimentally testable hypotheses. Here we use existing MSMs for the villin headpiece and NTL9, which were constructed from atomistic simulations, to accomplish this goal. In addition, we provide simpler, humanly comprehensible networks that capture the essence of molecular kinetics and reproduce qualitative phenomena like the apparent two-state folding often seen in experiments. Together, these models show that protein dynamics are dominated by stochastic jumps between numerous metastable states and that proteins have heterogeneous unfolded states (many unfolded basins that interconvert more rapidly with the native state than with one another) yet often still appear two-state. Most importantly, we find that protein native states are hubs that can be reached quickly from any other state. However, metastability and a web of nonnative states slow the average folding rate. Experimental tests for these findings and their implications for other fields, like protein design, are also discussed. PMID:20534497

  2. Sequential self-folding of polymer sheets

    PubMed Central

    Liu, Ying; Shaw, Brandi; Dickey, Michael D.; Genzer, Jan

    2017-01-01

    Shape plays an important role in defining the function of materials, particularly those found in nature. Several strategies exist to program materials to change from one shape to another; however, few can temporally and spatially control the shape. Programming the sequence of shape transformation with temporal control has been driven by the desire to generate complex shapes with high yield and to create multiple shapes from the same starting material. This paper demonstrates a markedly simple strategy for programmed self-folding of two-dimensional (2D) polymer sheets into 3D objects in a sequential manner using external light. Printed ink on the surface of the polymer sheets discriminately absorbs light on the basis of the wavelength of the light and the color of the ink that defines the hinge about which the sheet folds. The absorbed light gradually heats the underlying polymer across the thickness of the sheet, which causes relief of strain to induce folding. These color patterns can be designed to absorb only specific wavelengths of light (or to absorb differently at the same wavelength using color hues), thereby providing control of sheet folding with respect to time and space. This type of shape programming may have numerous applications, including reconfigurable electronics, actuators, sensors, implantable devices, smart packaging, and deployable structures. PMID:28275736

  3. Adaptive Origami for Efficiently Folded Structures

    DTIC Science & Technology

    2016-02-01

    4 3.2 Design of 2D-to- 3D Actuating Mechanisms...printing, lithography) to convert surface patterns on substrates into stable 3D objects. The design and fabrication of structures based on folding...Nafion, where prescribed 3D geometric information can be encoded as a spatially patterned composite of discrete shape-memory and locked-shape-memory

  4. Fold in Origami and Unfold Math

    ERIC Educational Resources Information Center

    Georgeson, Joseph

    2011-01-01

    Students enjoy origami and like making everything from paper cranes to footballs out of small, colorful squares of paper. They can invent their own shapes and are intrigued by the polyhedrons that they can construct. Paper folding is fun, but where is the math? Unless teachers develop lessons that address mathematical objectives, origami could be…

  5. Coiling and Folding of Viscoelastic Jets

    NASA Astrophysics Data System (ADS)

    Majmudar, Trushant; Varagnat, Matthieu; McKinley, Gareth

    2007-11-01

    The study of fluid jets impacting on a flat surface has industrial applications in many areas, including processing of foods and consumer goods, bottle filling, and polymer melt processing. Previous studies have focused primarily on purely viscous, Newtonian fluids, which exhibit a number of different dynamical regimes including dripping, steady jetting, folding, and steady coiling. Here we add another dimension to the problem by focusing on mobile (low viscosity) viscoelastic fluids, with the study of two wormlike-micellar fluids, a cetylpyridinum-salicylic acid salt (CPyCl/NaSal) solution, and an industrially relevant shampoo base. We investigate the effects of viscosity and elasticity on the dynamics of axi-symmetric jets. The viscoelasticity of the fluids is systematically controlled by varying the concentration of salt counterions. Experimental methods include shear and extensional rheology measurements to characterize the fluids, and high-speed digital video imaging. In addition to the regimes observed in purely viscous systems, we also find a novel regime in which the elastic jet buckles and folds on itself, and alternates between coiling and folding behavior. We suggest phase diagrams and scaling laws for the coiling and folding frequencies through a systematic exploration of the experimental parameter space (height of fall, imposed flow rate, elasticity of the solution).

  6. Clinical evaluation of vocal fold paralysis.

    PubMed

    Richardson, Brent E; Bastian, Robert W

    2004-02-01

    Vocal fold paralysis is regarded as a sign of other pathologic findings until investigation has proven that there is no lesion to explain the paralysis. We have outlined a cost-effective and time- and labor-efficient method for the clinical evaluation of vocal fold paralysis, including a focused history; vocal capability assessment to find deficits in the function of palate,pharynx, and larynx: and, finally, an intense examination under topical anesthesia to demonstrate these deficits. In essence, it is the endoscopic version of a radiographic study from the skull base through the aortic arch. This method is streamlined as compared with prior protocols for evaluation of vocal fold paralysis, because it directs the necessary further workup according to the likely site of the lesion as indicated by the extended physical examination and can be conducted entirely in the physician's office. Radiographic workup should include CT of the skull base through the upper mediastinum if solely a recurrent nerve paralysis is present; it should include MRI of the skull base if high vagal signs and symptoms are present. If MRI is negative, CT may also be needed for complete evaluation. Neurologic signs that are not all ipsilateral require MRI of the brain and consultation with a neurologist. Esophageal obstruction combined with vocal fold paralysis mandates evaluation via esophagoscopy or an esophagram.

  7. Folded cavity design for a ruby resonator

    NASA Technical Reports Server (NTRS)

    Arunkumar, K. A.; Trolinger, James D.

    1988-01-01

    A folded cavity laser resonator operating in the TEM(00) mode has been built and tested. The new oscillator configuration leads to an increase in efficiency and to better line narrowing due to the increased number of passes through the laser rod and tuning elements, respectively. The modification is shown to lead to cavity ruggedization.

  8. Folded-path optical analysis gas cell

    DOEpatents

    Carangelo, R.M.; Wright, D.D.

    1995-08-08

    A folded-path gas cell employs an elliptical concave mirror in confronting relationship to two substantially spherical concave mirrors. At least one of the spherical mirrors, and usually both, are formed with an added cylindrical component to increase orthogonal foci coincidence and thereby to increase the radiation energy throughput characteristic of the cell. 10 figs.

  9. Folded-path optical analysis gas cell

    DOEpatents

    Carangelo, Robert M.; Wright, David D.

    1995-01-01

    A folded-path gas cell employs an elliptical concave mirror in confronting relationship to two substantially spherical concave mirrors. At least one of the spherical mirrors, and usually both, are formed with an added cylindrical component to increase orthogonal focii coincidence and thereby to increase the radiation energy throughput characteristic of the cell.

  10. Folding and faulting of an elastic continuum

    PubMed Central

    Gourgiotis, Panos A.

    2016-01-01

    Folding is a process in which bending is localized at sharp edges separated by almost undeformed elements. This process is rarely encountered in Nature, although some exceptions can be found in unusual layered rock formations (called ‘chevrons’) and seashell patterns (for instance Lopha cristagalli). In mechanics, the bending of a three-dimensional elastic solid is common (for example, in bulk wave propagation), but folding is usually not achieved. In this article, the route leading to folding is shown for an elastic solid obeying the couple-stress theory with an extreme anisotropy. This result is obtained with a perturbation technique, which involves the derivation of new two-dimensional Green's functions for applied concentrated force and moment. While the former perturbation reveals folding, the latter shows that a material in an extreme anisotropic state is also prone to a faulting instability, in which a displacement step of finite size emerges. Another failure mechanism, namely the formation of dilation/compaction bands, is also highlighted. Finally, a geophysical application to the mechanics of chevron formation shows how the proposed approach may explain the formation of natural structures. PMID:27118925

  11. Fast phase randomization via two-folds.

    PubMed

    Simpson, D J W; Jeffrey, M R

    2016-02-01

    A two-fold is a singular point on the discontinuity surface of a piecewise-smooth vector field, at which the vector field is tangent to the discontinuity surface on both sides. If an orbit passes through an invisible two-fold (also known as a Teixeira singularity) before settling to regular periodic motion, then the phase of that motion cannot be determined from initial conditions, and, in the presence of small noise, the asymptotic phase of a large number of sample solutions is highly random. In this paper, we show how the probability distribution of the asymptotic phase depends on the global nonlinear dynamics. We also show how the phase of a smooth oscillator can be randomized by applying a simple discontinuous control law that generates an invisible two-fold. We propose that such a control law can be used to desynchronize a collection of oscillators, and that this manner of phase randomization is fast compared with existing methods (which use fixed points as phase singularities), because there is no slowing of the dynamics near a two-fold.

  12. How do metal ions direct ribozyme folding?

    NASA Astrophysics Data System (ADS)

    Denesyuk, Natalia A.; Thirumalai, D.

    2015-10-01

    Ribozymes, which carry out phosphoryl-transfer reactions, often require Mg2+ ions for catalytic activity. The correct folding of the active site and ribozyme tertiary structure is also regulated by metal ions in a manner that is not fully understood. Here we employ coarse-grained molecular simulations to show that individual structural elements of the group I ribozyme from the bacterium Azoarcus form spontaneously in the unfolded ribozyme even at very low Mg2+ concentrations, and are transiently stabilized by the coordination of Mg2+ ions to specific nucleotides. However, competition for scarce Mg2+ and topological constraints that arise from chain connectivity prevent the complete folding of the ribozyme. A much higher Mg2+ concentration is required for complete folding of the ribozyme and stabilization of the active site. When Mg2+ is replaced by Ca2+ the ribozyme folds, but the active site remains unstable. Our results suggest that group I ribozymes utilize the same interactions with specific metal ligands for both structural stability and chemical activity.

  13. Self-folding graphene-polymer bilayers

    SciTech Connect

    Deng, Tao; Yoon, ChangKyu; Jin, Qianru; Li, Mingen; Liu, Zewen; Gracias, David H.

    2015-05-18

    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  14. Resident education outcomes and perception of a seminar format to teach female pelvic anatomy and procedures to correct pelvic prolapse.

    PubMed

    Teichman, Joel M.H.; Cespedes, R. Duane; Littlefield, John H.

    1998-12-01

    Urologic residents need to learn basic and applied knowledge of female pelvic anatomy, a subject rarely taught beyond preclinical undergraduate medical education. This study tests the hypothesis that urologic resident knowledge of female pelvic anatomy and prolapse may be enhanced with a seminar. Twenty residents attended a one day seminar combining didactics and a cadaveric dissection related to female pelvic anatomy and female pelvic prolapse conditions. Resident knowledge was measured with a multiple choice test administered in a pretest-posttest experimental design. Resident attitudes toward the seminar were assessed by a 20 item survey using a strongly disagree to strongly agree scale. Pretest and posttest mean scores were 55% and 71% respectively, p=.0007 (Kuder-Richardson 20 coefficients were 0.7). Questionnaire responses indicated positive opinions regarding the educational value of the seminar. Urologic resident knowledge of female pelvic anatomy and pelvic prolapse conditions may be enhanced by conducting a one day teaching seminar.

  15. Fault-related folding during extension: Plunging basement-cored folds in the Basin and Range

    USGS Publications Warehouse

    Howard, K.A.; John, Barbara E.

    1997-01-01

    Folds are able to form in highly extended areas where stratified cover rocks respond to basement fault offsets. The response of cover rocks to basement faulting can be studied especially well in plunging structures that expose large structural relief. The southern Basin and Range province contains plunging folds kilometres in amplitude at the corners of domino-like tilt blocks of basement rocks, where initially steep transverse and normal faults propagated upward toward the layered cover rocks. Exposed tilted cross sections, as much as 8 km thick, display transitions from faulted basement to folded cover that validate laboratory models of forced folds. The folded cover masks a deeper extensional style of brittle segmentation and uniform steep tilting.

  16. Oxidative folding of peptides with cystine-knot architectures: kinetic studies and optimization of folding conditions.

    PubMed

    Reinwarth, Michael; Glotzbach, Bernhard; Tomaszowski, Michael; Fabritz, Sebastian; Avrutina, Olga; Kolmar, Harald

    2013-01-02

    Bioactive peptides often contain several disulfide bonds that provide the main contribution to conformational rigidity and structural, thermal, or biological stability. Among them, cystine-knot peptides-commonly named "knottins"-make up a subclass with several thousand natural members. Hence, they are considered promising frameworks for peptide-based pharmaceuticals. Although cystine-knot peptides are available through chemical and recombinant synthetic routes, oxidative folding to afford the bioactive isomers still remains a crucial step. We therefore investigated the oxidative folding of ten protease-inhibiting peptides from two knottin families, as well as that of an HIV entry inhibitor and of aprotinin, under two conventional sets of folding conditions and by a newly developed procedure. Kinetic studies identified folding conditions that resulted in correctly folded miniproteins with high rates of conversion even for highly hydrophobic and aggregation-prone peptides in concentrated solutions.

  17. Workflow in the operating room: review of Arrowhead 2004 seminar on imaging and informatics (Invited Paper)

    NASA Astrophysics Data System (ADS)

    Lemke, Heinz U.; Ratib, Osman M.; Horii, Steven C.

    2005-04-01

    This review paper is based on the 2004 UCLA Seminar on Imaging and Informatics (http://www.radnet.ucla.edu/Arrowhead2004/) which is a joint endeavour between the UCLA and the CARS organization, focussing on workflow analysis tools and the digital operating room. Eleven specific presentations of the Arrowhead Seminar have been summarized in this review referring to redesigning perioperative care for a high velocity OR, intraoperative ultrasound process and model, surgical workflow and surgical PACS, an integrated view , interactions in the surgical OR, workflow automation strategies and target applications, visualisation solutions for the operating room, navigating the fifth dimension, and design of digital operating rooms and interventional suites

  18. Congenital hypothyroidism mutations affect common folding and trafficking in the α/β-hydrolase fold proteins.

    PubMed

    De Jaco, Antonella; Dubi, Noga; Camp, Shelley; Taylor, Palmer

    2012-12-01

    The α/β-hydrolase fold superfamily of proteins is composed of structurally related members that, despite great diversity in their catalytic, recognition, adhesion and chaperone functions, share a common fold governed by homologous residues and conserved disulfide bridges. Non-synonymous single nucleotide polymorphisms within the α/β-hydrolase fold domain in various family members have been found for congenital endocrine, metabolic and nervous system disorders. By examining the amino acid sequence from the various proteins, mutations were found to be prevalent in conserved residues within the α/β-hydrolase fold of the homologous proteins. This is the case for the thyroglobulin mutations linked to congenital hypothyroidism. To address whether correct folding of the common domain is required for protein export, we inserted the thyroglobulin mutations at homologous positions in two correlated but simpler α/β-hydrolase fold proteins known to be exported to the cell surface: neuroligin3 and acetylcholinesterase. Here we show that these mutations in the cholinesterase homologous region alter the folding properties of the α/β-hydrolase fold domain, which are reflected in defects in protein trafficking, folding and function, and ultimately result in retention of the partially processed proteins in the endoplasmic reticulum. Accordingly, mutations at conserved residues may be transferred amongst homologous proteins to produce common processing defects despite disparate functions, protein complexity and tissue-specific expression of the homologous proteins. More importantly, a similar assembly of the α/β-hydrolase fold domain tertiary structure among homologous members of the superfamily is required for correct trafficking of the proteins to their final destination.

  19. Nomenclature proposal to describe vocal fold motion impairment.

    PubMed

    Rosen, Clark A; Mau, Ted; Remacle, Marc; Hess, Markus; Eckel, Hans E; Young, VyVy N; Hantzakos, Anastasios; Yung, Katherine C; Dikkers, Frederik G

    2016-08-01

    The terms used to describe vocal fold motion impairment are confusing and not standardized. This results in a failure to communicate accurately and to major limitations of interpreting research studies involving vocal fold impairment. We propose standard nomenclature for reporting vocal fold impairment. Overarching terms of vocal fold immobility and hypomobility are rigorously defined. This includes assessment techniques and inclusion and exclusion criteria for determining vocal fold immobility and hypomobility. In addition, criteria for use of the following terms have been outlined in detail: vocal fold paralysis, vocal fold paresis, vocal fold immobility/hypomobility associated with mechanical impairment of the crico-arytenoid joint and vocal fold immobility/hypomobility related to laryngeal malignant disease. This represents the first rigorously defined vocal fold motion impairment nomenclature system. This provides detailed definitions to the terms vocal fold paralysis and vocal fold paresis.

  20. [4 anthroposcopic markers in the Northern Greece population: hand folding, arm folding, tongue rolling and tongue folding].

    PubMed

    Pentzos-Daponte, A

    1986-03-01

    Four anthroposcopic traits, namely hand clasping, arm folding, tongue rolling and tongue curling have been studied in a total of 7763 individuals from Thessaloniki and its surroundings, representing a sample of the population of Northern Greece. The statistical analysis of the data indicates significant sex differences only concerning tongue rolling. The frequencies obtained for the four traits under study are compared with data from the literature.

  1. The shape and mechanics of curved-fold origami structures

    NASA Astrophysics Data System (ADS)

    Dias, Marcelo A.; Santangelo, Christian D.

    2012-12-01

    We develop recursion equations to describe the three-dimensional shape of a sheet upon which a series of concentric curved folds have been inscribed. In the case of no stretching outside the fold, the three-dimensional shape of a single fold prescribes the shape of the entire origami structure. To better explore these structures, we derive continuum equations, valid in the limit of vanishing spacing between folds, to describe the smooth surface intersecting all the mountain folds. We find that this surface has negative Gaussian curvature with magnitude equal to the square of the fold's torsion. A series of open folds with constant fold angle generate a helicoid.

  2. Microfluidic Mixers for Studying Protein Folding

    PubMed Central

    Waldauer, Steven A.; Wu, Ling; Yao, Shuhuai; Bakajin, Olgica; Lapidus, Lisa J.

    2012-01-01

    The process by which a protein folds into its native conformation is highly relevant to biology and human health yet still poorly understood. One reason for this is that folding takes place over a wide range of timescales, from nanoseconds to seconds or longer, depending on the protein1. Conventional stopped-flow mixers have allowed measurement of folding kinetics starting at about 1 ms. We have recently developed a microfluidic mixer that dilutes denaturant ~100-fold in ~8 μs2. Unlike a stopped-flow mixer, this mixer operates in the laminar flow regime in which turbulence does not occur. The absence of turbulence allows precise numeric simulation of all flows within the mixer with excellent agreement to experiment3-4. Laminar flow is achieved for Reynolds numbers Re ≤100. For aqueous solutions, this requires micron scale geometries. We use a hard substrate, such as silicon or fused silica, to make channels 5-10 μm wide and 10 μm deep (See Figure 1). The smallest dimensions, at the entrance to the mixing region, are on the order of 1 μm in size. The chip is sealed with a thin glass or fused silica coverslip for optical access. Typical total linear flow rates are ~1 m/s, yielding Re~10, but the protein consumption is only ~0.5 nL/s or 1.8 μL/hr. Protein concentration depends on the detection method: For tryptophan fluorescence the typical concentration is 100 μM (for 1 Trp/protein) and for FRET the typical concentration is ~100 nM. The folding process is initiated by rapid dilution of denaturant from 6 M to 0.06 M guanidine hydrochloride. The protein in high denaturant flows down a central channel and is met on either side at the mixing region by buffer without denaturant moving ~100 times faster (see Figure 2). This geometry causes rapid constriction of the protein flow into a narrow jet ~100 nm wide. Diffusion of the light denaturant molecules is very rapid, while diffusion of the heavy protein molecules is much slower, diffusing less than 1 μm in 1 ms

  3. Vocal fold and ventricular fold vibration in period-doubling phonation: physiological description and aerodynamic modeling.

    PubMed

    Bailly, Lucie; Henrich, Nathalie; Pelorson, Xavier

    2010-05-01

    Occurrences of period-doubling are found in human phonation, in particular for pathological and some singing phonations such as Sardinian A Tenore Bassu vocal performance. The combined vibration of the vocal folds and the ventricular folds has been observed during the production of such low pitch bass-type sound. The present study aims to characterize the physiological correlates of this acoustical production and to provide a better understanding of the physical interaction between ventricular fold vibration and vocal fold self-sustained oscillation. The vibratory properties of the vocal folds and the ventricular folds during phonation produced by a professional singer are analyzed by means of acoustical and electroglottographic signals and by synchronized glottal images obtained by high-speed cinematography. The periodic variation in glottal cycle duration and the effect of ventricular fold closing on glottal closing time are demonstrated. Using the detected glottal and ventricular areas, the aerodynamic behavior of the laryngeal system is simulated using a simplified physical modeling previously validated in vitro using a larynx replica. An estimate of the ventricular aperture extracted from the in vivo data allows a theoretical prediction of the glottal aperture. The in vivo measurements of the glottal aperture are then compared to the simulated estimations.

  4. Start2Fold: a database of hydrogen/deuterium exchange data on protein folding and stability

    PubMed Central

    Pancsa, Rita; Varadi, Mihaly; Tompa, Peter; Vranken, Wim F.

    2016-01-01

    Proteins fulfil a wide range of tasks in cells; understanding how they fold into complex three-dimensional (3D) structures and how these structures remain stable while retaining sufficient dynamics for functionality is essential for the interpretation of overall protein behaviour. Since the 1950's, solvent exchange-based methods have been the most powerful experimental means to obtain information on the folding and stability of proteins. Considerable expertise and care were required to obtain the resulting datasets, which, despite their importance and intrinsic value, have never been collected, curated and classified. Start2Fold is an openly accessible database (http://start2fold.eu) of carefully curated hydrogen/deuterium exchange (HDX) data extracted from the literature that is open for new submissions from the community. The database entries contain (i) information on the proteins investigated and the underlying experimental procedures and (ii) the classification of the residues based on their exchange protection levels, also allowing for the instant visualization of the relevant residue groups on the 3D structures of the corresponding proteins. By providing a clear hierarchical framework for the easy sharing, comparison and (re-)interpretation of HDX data, Start2Fold intends to promote a better understanding of how the protein sequence encodes folding and structure as well as the development of new computational methods predicting protein folding and stability. PMID:26582925

  5. Fast-Folding Proteins under Stress

    PubMed Central

    Dave, Kapil; Gruebele, Martin

    2015-01-01

    Proteins are subject to a variety of stresses in biological organisms, including pressure and temperature, which are the easiest stresses to simulate by molecular dynamics. We discuss the effect of pressure and thermal stress on very fast folding model proteins, whose in vitro folding can be fully simulated on computers and compared with experiments. We then discuss experiments that can be used to subject proteins to low and high temperature unfolding, as well as low and high pressure unfolding. Pressure and temperature are prototypical perturbations that illustrate how close many proteins are to instability, a property that cells can exploit to control protein function. We conclude by reviewing some recent in-cell experiments, and progress being made in simulating and measuring protein stability and function inside live cells. PMID:26231095

  6. Chevron folding patterns and heteroclinic orbits

    NASA Astrophysics Data System (ADS)

    Budd, Christopher J.; Chakhchoukh, Amine N.; Dodwell, Timothy J.; Kuske, Rachel

    2016-09-01

    We present a model of multilayer folding in which layers with bending stiffness EI are separated by a very stiff elastic medium of elasticity k2 and subject to a horizontal load P. By using a dynamical system analysis of the resulting fourth order equation, we show that as the end shortening per unit length E is increased, then if k2 is large there is a smooth transition from small amplitude sinusoidal solutions at moderate values of P to larger amplitude chevron folds, with straight limbs separated by regions of high curvature when P is large. The chevron solutions take the form of near heteroclinic connections in the phase-plane. By means of this analysis, values for P and the slope of the limbs are calculated in terms of E and k2.

  7. Convoluted accommodation structures in folded rocks

    NASA Astrophysics Data System (ADS)

    Dodwell, T. J.; Hunt, G. W.

    2012-10-01

    A simplified variational model for the formation of convoluted accommodation structures, as seen in the hinge zones of larger-scale geological folds, is presented. The model encapsulates some important and intriguing nonlinear features, notably: infinite critical loads, formation of plastic hinges, and buckling on different length-scales. An inextensible elastic beam is forced by uniform overburden pressure and axial load into a V-shaped geometry dictated by formation of a plastic hinge. Using variational methods developed by Dodwell et al., upon which this paper leans heavily, energy minimisation leads to representation as a fourth-order nonlinear differential equation with free boundary conditions. Equilibrium solutions are found using numerical shooting techniques. Under the Maxwell stability criterion, it is recognised that global energy minimisers can exist with convoluted physical shapes. For such solutions, parallels can be drawn with some of the accommodation structures seen in exposed escarpments of real geological folds.

  8. Predictive Computational Modeling of Chromatin Folding

    NASA Astrophysics Data System (ADS)

    di Pierro, Miichele; Zhang, Bin; Wolynes, Peter J.; Onuchic, Jose N.

    In vivo, the human genome folds into well-determined and conserved three-dimensional structures. The mechanism driving the folding process remains unknown. We report a theoretical model (MiChroM) for chromatin derived by using the maximum entropy principle. The proposed model allows Molecular Dynamics simulations of the genome using as input the classification of loci into chromatin types and the presence of binding sites of loop forming protein CTCF. The model was trained to reproduce the Hi-C map of chromosome 10 of human lymphoblastoid cells. With no additional tuning the model was able to predict accurately the Hi-C maps of chromosomes 1-22 for the same cell line. Simulations show unknotted chromosomes, phase separation of chromatin types and a preference of chromatin of type A to sit at the periphery of the chromosomes.

  9. Vocal fold mobility alteration reversed after thyroidectomy

    PubMed Central

    Miazaki, Aline Paterno; Araújo-Filho, Vergilius José Furtado; Brandão, Lenine Garcia; de Araujo-Neto, Vergilius José Furtado; Cernea, Claudio Roberto

    2016-01-01

    The involvement of the inferior or recurrent laryngeal nerve (RLN) in mobility derangement of the vocal folds occurs more frequently due to thyroid malignancy invasion. Although uncommon, the same derangement, which is caused by benign thyroid entities, is also described and reverts to normality after a thyroidectomy in up to 89% of cases. In these cases, the pathogenesis of the vocal cord mobility disturbance is attributed to the direct compression of the RLN by massive thyroid enlargement. The authors describe three cases of patients presenting unilateral vocal cord palsy, which, before surgery, was diagnosed by laryngoscopy concomitantly with large and compressive goiter. Vocal fold mobility became normal after the thyroidectomy in all three cases. Therefore, it is noteworthy that these alterations may present reversibility after appropriate surgical treatment. An early surgical approach is recommended to reduce the nerve injury as much as possible; to preserve the integrity of both RLNs since the nerve function will be restored in some patients. PMID:27818960

  10. Folded membrane dialyzer with mechanically sealed edges

    DOEpatents

    Markley, Finley W.

    1976-01-01

    A semipermeable membrane is folded in accordion fashion to form a stack of pleats and the edges are sealed so as to isolate the opposite surfaces of the membrane. The stack is contained within a case that provides ports for flow of blood in contact with one surface of the membrane through channels formed by the pleats and also provides ports for flow of a dialysate through channels formed by the pleats in contact with the other surface of the membrane. The serpentine side edges of the membrane are sealed by a solidified plastic material, whereas effective mechanical means are provided to seal the end edges of the folded membrane. The mechanical means include a clamping strip which biases case sealing flanges into a sealed relationship with end portions of the membrane near the end edges, which portions extend from the stack and between the sealing flanges.

  11. Ubiquitylation Directly Induces Fold Destabilization of Proteins

    PubMed Central

    Morimoto, Daichi; Walinda, Erik; Fukada, Harumi; Sugase, Kenji; Shirakawa, Masahiro

    2016-01-01

    Ubiquitin is a common post-translational modifier and its conjugation is a key signal for proteolysis by the proteasome. Because the molecular mass of ubiquitin is larger than that of other modifiers such as phosphate, acetyl, or methyl groups, ubiquitylation not only influences biochemical signaling, but also may exert physical effects on its substrate proteins by increasing molecular volume and altering shape anisotropy. Here we show that ubiquitylation destabilizes the fold of two proteins, FKBP12 and FABP4, and that elongation of the conjugated ubiquitin chains further enhances this destabilization effect. Moreover, NMR relaxation analysis shows that ubiquitylation induces characteristic structural fluctuations in the backbone of both proteins. These results suggest that the ubiquitylation-driven structural fluctuations lead to fold destabilization of its substrate proteins. Thus, physical destabilization by ubiquitylation may facilitate protein degradation by the proteasome. PMID:27991582

  12. PREFACE Protein folding: lessons learned and new frontiers Protein folding: lessons learned and new frontiers

    NASA Astrophysics Data System (ADS)

    Pappu, Rohit V.; Nussinov, Ruth

    2009-03-01

    In appropriate physiological milieux proteins spontaneously fold into their functional three-dimensional structures. The amino acid sequences of functional proteins contain all the information necessary to specify the folds. This remarkable observation has spawned research aimed at answering two major questions. (1) Of all the conceivable structures that a protein can adopt, why is the ensemble of native-like structures the most favorable? (2) What are the paths by which proteins manage to robustly and reproducibly fold into their native structures? Anfinsen's thermodynamic hypothesis has guided the pursuit of answers to the first question whereas Levinthal's paradox has influenced the development of models for protein folding dynamics. Decades of work have led to significant advances in the folding problem. Mean-field models have been developed to capture our current, coarse grain understanding of the driving forces for protein folding. These models are being used to predict three-dimensional protein structures from sequence and stability profiles as a function of thermodynamic and chemical perturbations. Impressive strides have also been made in the field of protein design, also known as the inverse folding problem, thereby testing our understanding of the determinants of the fold specificities of different sequences. Early work on protein folding pathways focused on the specific sequence of events that could lead to a simplification of the search process. However, unifying principles proved to be elusive. Proteins that show reversible two-state folding-unfolding transitions turned out to be a gift of natural selection. Focusing on these simple systems helped researchers to uncover general principles regarding the origins of cooperativity in protein folding thermodynamics and kinetics. On the theoretical front, concepts borrowed from polymer physics and the physics of spin glasses led to the development of a framework based on energy landscape theories. These

  13. Heat capacity change for ribonuclease A folding.

    PubMed Central

    Pace, C. N.; Grimsley, G. R.; Thomas, S. T.; Makhatadze, G. I.

    1999-01-01

    The change in heat capacity deltaCp for the folding of ribonuclease A was determined using differential scanning calorimetry and thermal denaturation curves. The methods gave equivalent results, deltaCp = 1.15+/-0.08 kcal mol(-1) K(-1). Estimates of the conformational stability of ribonuclease A based on these results from thermal unfolding are in good agreement with estimates from urea unfolding analyzed using the linear extrapolation method. PMID:10422839

  14. Calnexin, calreticulin and the folding of glycoproteins.

    PubMed

    1997-05-01

    Calnexin and calreticulin are molecular chaperones in the endoplasmic reticulum (ERJ. They are lectins that interact with newly synthesized glycoproteins that have undergone partial trimming of their core N-linked oligosaccharides. Together with the enzymes responsible for glucose removal and a glucosyltransferase that re-glucosylates already-trimmed glycoproteins, they provide a novel mechanism for promoting folding, oligomeric assembly and quality control in the ER.

  15. Chen’s Double Eyelid Fold Ratio

    PubMed Central

    Chen, Chen-Chia; Tai, Hao-Chih

    2016-01-01

    Background: Double eyelidplasty can construct palpebral folds and enhance beauty perception for Asians with single eyelids. A new palpebral parameter for the quantitative interpretation of surgical outcomes is proposed on the basis of a photometric study of the altered proportions of Asian eyes after double eyelid operation. Methods: A total of 100 Asian adults with single upper eyelids who were satisfied with the enlarged eyes by operation were included in the study. A retrospective measurement of palpebral parameters in the frontal profile both preoperatively and 6 months postoperatively was performed. The proportions of various parameters in the eyebrow–eye aesthetic unit were calculated and analyzed. Results: Double eyelidplasty can augment the vertical dimension of palpebral fissure by 27.9% increase on average. The vertical ratio of palpebral fissure to the eyebrow–eye unit is augmented by 34.4% increase. The vertical ratio of the subunit below double eyelid fold peak to the unit is augmented by 82.6% increase. Conclusions: Double eyelidplasty can substantially enlarge the vertical dimensions of the eyes of Asians with single eyelids. The eyes are perceived to be larger because of the visually assimilated illusion of the superimposed eyelid fold and the relative proportions of the eyebrow–eye unit. The authors propose using a vertical ratio of the subunit below double eyelid fold peak in the eyebrow–eye unit to measure the visually perceived proportion of the eye in the unit. This ratio can be applied clinically for a quantitative evaluation of the surgical outcome after double eyelidplasty. PMID:27200243

  16. Resummation of semiclassical short folded string

    NASA Astrophysics Data System (ADS)

    Beccaria, Matteo; Macorini, Guido

    2012-02-01

    We reconsider semiclassical quantization of folded string spinning in AdS3 part of AdS5 × S5 using integrability-based (algebraic curve) method. We focus on the "short string" (small spin S) limit with the angular momentum J in S 5 scaled down according to {mathcal J} = ρ sqrt {S} in terms of the variables {mathcal J} = J/ sqrt {λ } , S = S/ sqrt {λ } . The semi-classical string energy in this particular scaling limit admits the double expansion E = {sum {_{{n = 0}}^{infty }sum {_{{p = 0}}^{infty }left( {sqrt {λ } } right)} }^{{1 - n}}}{a_{{n,p}}}left( ρ right){S^{{P + 1/2}}} . It behaves smoothly as J → 0 and partially resums recent results by Gromov and Valatka. We explicitly compute various one-loop coefficients a1, p ( ρ) by summing over the fluctuation frequencies for integrable perturbations around the classical solution. For the simple folded string, the result agrees with what could be derived exploiting a recent conjecture of Basso. However, the method can be extended to more general situations. As an example, we consider the m-folded string where Basso's conjecture fails. For this classical solution, we present the exact values of a 1,0( ρ) and a 1,1( ρ) for m = 2, 3, 4, 5 and explain how to work out the general case.

  17. Is Protein Folding Sub-Diffusive?

    PubMed Central

    Krivov, Sergei V.

    2010-01-01

    Protein folding dynamics is often described as diffusion on a free energy surface considered as a function of one or few reaction coordinates. However, a growing number of experiments and models show that, when projected onto a reaction coordinate, protein dynamics is sub-diffusive. This raises the question as to whether the conventionally used diffusive description of the dynamics is adequate. Here, we numerically construct the optimum reaction coordinate for a long equilibrium folding trajectory of a Go model of a -repressor protein. The trajectory projected onto this coordinate exhibits diffusive dynamics, while the dynamics of the same trajectory projected onto a sub-optimal reaction coordinate is sub-diffusive. We show that the higher the (cut-based) free energy profile for the putative reaction coordinate, the more diffusive the dynamics become when projected on this coordinate. The results suggest that whether the projected dynamics is diffusive or sub-diffusive depends on the chosen reaction coordinate. Protein folding can be described as diffusion on the free energy surface as function of the optimum reaction coordinate. And conversely, the conventional reaction coordinates, even though they might be based on physical intuition, are often sub-optimal and, hence, show sub-diffusive dynamics. PMID:20862361

  18. Understanding the folding-function tradeoff in proteins.

    PubMed

    Gosavi, Shachi

    2013-01-01

    When an amino-acid sequence cannot be optimized for both folding and function, folding can get compromised in favor of function. To understand this tradeoff better, we devise a novel method for extracting the "function-less" folding-motif of a protein fold from a set of structurally similar but functionally diverse proteins. We then obtain the β-trefoil folding-motif, and study its folding using structure-based models and molecular dynamics simulations. CompariA protein sequence serves two purpson with the folding of wild-type β-trefoil proteins shows that function affects folding in two ways: In the slower folding interleukin-1β, binding sites make the fold more complex, increase contact order and slow folding. In the faster folding hisactophilin, residues which could have been part of the folding-motif are used for function. This reduces the density of native contacts in functional regions and increases folding rate. The folding-motif helps identify subtle structural deviations which perturb folding. These may then be used for functional annotation. Further, the folding-motif could potentially be used as a first step in the sequence design of function-less scaffold proteins. Desired function can then be engineered into these scaffolds.

  19. Spreadsheets and Seminars: Business Office Helps Employees Make Retirement Plan Decision.

    ERIC Educational Resources Information Center

    Wamsley, Patrick

    1991-01-01

    To inform faculty and staff about the new state retirement plan and help them compare its benefits with those of the only existing employer-sponsored retirement plan for educators, a defined-benefit plan, Georgia Institute of Technology used an electronic spreadsheet and a series of seminars for analyzing and illustrating investment options. (MSE)

  20. Street and Working Children. Innocenti Global Seminar (Florence, Italy, February 15-25, 1993). Summary Report.

    ERIC Educational Resources Information Center

    Black, Maggie

    This report describes a seminar designed to develop a better understanding of the problems and needs of working children and children living in the streets, to analyze policy and program experiences in working with such children, and to draft a set of recommendations to help improve the conditions of street and working children in the context of…

  1. Proceedings of the Fourth International Seminar on Special Education (Cork, Ireland, September 8-12, 1969).

    ERIC Educational Resources Information Center

    McHugh, M. F., Ed.

    Proceedings of the Fourth International Seminar on Special Education (Cork, Ireland, September 8-12, 1969) contain papers relating to the following themes: special education personnel, identification of the handicapped, general aspects of early education, special education methods, early education programs for the mentally handicapped, and early…

  2. Reflection on Teachers' Personal and Professional Growth through a Materials Development Seminar

    ERIC Educational Resources Information Center

    Núñez Pardo, Astrid; Téllez Téllez, María Fernanda

    2016-01-01

    This qualitative action research study explores the role of reflection on teachers' personal and professional growth through the methodology used in the Materials Development Seminar in the Master's Programme in Education with Emphasis on English Didactics at a private university in Colombia. The project was carried out with 31 English as a…

  3. Quantitative Evaluation of a First Year Seminar Program: Relationships to Persistence and Academic Success

    ERIC Educational Resources Information Center

    Jenkins-Guarnieri, Michael A.; Horne, Melissa M.; Wallis, Aaron L.; Rings, Jeffrey A.; Vaughan, Angela L.

    2015-01-01

    In the present study, we conducted a quantitative evaluation of a novel First Year Seminar (FYS) program with a coordinated curriculum implemented at a public, four-year university to assess its potential role in undergraduate student persistence decisions and academic success. Participants were 2,188 first-year students, 342 of whom completed the…

  4. Utilizing the Myers-Briggs Personality Inventory in Employee Assistance Program Workplace Seminars.

    ERIC Educational Resources Information Center

    Aviles, Christopher B.

    Social work educators are being called upon more often to deliver employee workplace seminars for community agencies on a variety of topics ranging from burnout and stress management to improving workplace communication and managing workplace conflicts. One tool that addresses workplace communication is the Myers-Briggs Type Indicator (MBTI). It…

  5. China: Tradition and Transformation Curriculum Projects. Fulbright-Hays Summer Seminars Abroad Program, 2001 (China).

    ERIC Educational Resources Information Center

    National Committee on United States-China Relations, New York, NY.

    The curriculum projects in this collection represent the culmination of a Fulbright-Hays summer seminar for educators which took place in China in 2001. The collection contains 16 curriculum projects: "Notes on Giving a Presentation to a Parents Group, School Board or Other Public Audience Regarding Modern China" (David Bilka);…

  6. A Three-Year Chemistry Seminar Program Focusing on Career Development Skills

    ERIC Educational Resources Information Center

    Tucci, Valerie K.; O'Connor, Abby R.; Bradley, Lynn M.

    2014-01-01

    An innovative, three-year seminar program was developed for undergraduates at The College of New Jersey (TCNJ) that supplements the core chemistry curriculum by teaching the auxiliary skills necessary for life as a professional chemist. Advising, good laboratory practice, and information literacy are the strategic components of this program that…

  7. Research in Adult Education. Proceedings of the National Seminar (Hyderabad, India, February 28-March 3, 1982).

    ERIC Educational Resources Information Center

    Bhatia, S. C., Ed.; Patil, B. R., Ed.

    These proceedings contain 17 papers presented at a seminar to identify and evaluate research studies conducted in the past with a view to providing guidance and ready reference for those who wish to conduct research in the future. A summary of recommendations appears first. Issues, researchable questions, and suggestions are made in three areas:…

  8. [Comparative Migration Studies and Comparative Politics.] Fulbright-Hays Summer Seminars Abroad, 1997 (India).

    ERIC Educational Resources Information Center

    Ireland, Patrick

    This paper addresses how the experience of the Fulbright Seminar in India has allowed the participant to enrich his teaching in comparative migration studies and comparative politics. The paper describes specifically how each course has changed as a result of the international experience. The report suggests questions for consideration as the…

  9. Ethical Sentiments and the Role of Literature in the Jurisprudence Seminar

    ERIC Educational Resources Information Center

    Penrod, Lynn

    2010-01-01

    This article focuses on a typical law and literature jurisprudence seminar and the use of literary texts in this type of class to foster the development of "ethical sentiments" in future legal practitioners. While the majority of jurisprudence courses within a standard law curriculum tend to use political theory, philosophical, or socio-cultural…

  10. Findings from an Independent Evaluation of the AMNH's Online Seminars on Science Course: "The Solar System"

    ERIC Educational Resources Information Center

    Inverness Research, 2009

    2009-01-01

    Inverness Research studied the American Museum of Natural History (AMNH) Seminars on Science program for eight years, from its inception in 1998 to 2006. In 2009, Inverness Research conducted additional studies of the AMNH's new online course, The Solar System. This paper presents teacher survey ratings for The Solar System, along with profiles of…

  11. Books and National Development. Seminar Report April 27-29, 1968, Academy House, Seoul.

    ERIC Educational Resources Information Center

    Korean Publishers Association, Seoul.

    Representatives from Korea, China, Indonesia, Japan, Thailand, the United States and Southeast Asian Ministers of Education (SEAMES) attended an international seminar to reaffirm the importance of books as national development tools, to seek measures for having it reflected in the national policies and to promote international cooperation in book…

  12. Fulbright-Hays Summer Seminars Abroad Program 1989. Egypt: Transition to the Modern World.

    ERIC Educational Resources Information Center

    Office of International Education (ED), Washington, DC.

    This document consists of four papers on various aspects of development in Egypt prepared by participants in the Fulbright-Hays Seminars Abroad Program in Egypt in 1989. Four of the papers are descriptive, one is a lesson plan. The papers included are: (1) "Egypt: Transition to Modern Times" (Katherine Jensen) focuses on the role of…

  13. Evaluation of Educational Systems. Contributions to a Seminar (IIEP, Paris, France, May 29-June 2, 1972).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    This publication contains a report describing a May 1972 seminar sponsored by the International Institute for Educational Planning to discuss current approaches to educational evaluation. In addition, the following 11 papers presented at the conference are included in their entirety: "Possible Criteria for Evaluating Education Policies," by R.…

  14. Teaching an Interpersonal Senior Seminar Partially via the Internet (Computer Conferencing).

    ERIC Educational Resources Information Center

    Cahn, Dudley D.

    This paper reports on a college educator's attempts over the past two years to use computer conferencing via the Internet as a 3-week unit in a semester-long senior level seminar in Interpersonal Communication. The paper states that the educator wanted to see if he could successfully add computer conferencing as a part of an existing face-to-face…

  15. VOCATIONAL-TECHNICAL TEACHER EDUCATION--NATIONAL SEMINAR PROCEEDINGS (SEPTEMBER 24-29, 1967). LEADERSHIP 15.

    ERIC Educational Resources Information Center

    VIVIAN, NEAL E.; HOFFMAN, KENNETH E.

    APPROXIMATELY 300 TEACHER-EDUCATORS AND NATIONAL LEADERS AND EXPERTS IN EDUCATION AND RELATED DISCIPLINES FROM 46 STATES, TWO TERRITORIES, AND TWO CANADIAN PROVINCES PARTICIPATED IN A SEMINAR TO IDENTIFY ALTERNATIVE APPROACHES FOR IMPROVING PROGRAMS IN PREPARING AND UPGRADING VOCATIONAL TEACHERS. MAJOR SPEECHES INCLUDED--(1) "URGENCY OF THE DEMAND…

  16. In Search of Ernest Hemingway: A Model for Teaching a Literature Seminar.

    ERIC Educational Resources Information Center

    Workman, Brooke

    Intended for use every day for a semester, this secondary seminar handbook provides a schedule, lesson plans, materials for classroom distribution, and a bibliography for a course designed to teach critical reading and basic writing skills through an in-depth study of Ernest Hemingway. Because the course requires that students write seven position…

  17. Proceedings of the advanced seminar on sedimentation, August 15-19, 1983, Denver, Colorado

    USGS Publications Warehouse

    Glysson, G. D.

    1985-01-01

    On August 15-19, 1983, the U.S. Geological Survey 's Water Resources Division sponsored an advanced seminar on sedimentation at the National Training Center in Lakewood, Colorado. Topics discussed were modeling, mud, and debris flows, transport, sediment chemistry, channel morphology, instrumentation, and bed load. This circular presents summaries of 28 presentations. (USGS)

  18. Impacting Information Literacy Learning in First-Year Seminars: A Rubric-Based Evaluation

    ERIC Educational Resources Information Center

    Lowe, M. Sara; Booth, Char; Stone, Sean; Tagge, Natalie

    2015-01-01

    The authors conducted a rubric assessment of information literacy (IL) skills in research papers across five undergraduate first-year seminar programs to explore the question "What impact does librarian intervention in first-year courses have on IL performance in student work?" Statistical results indicate that students in courses with…

  19. China: Tradition and Transformation. Curriculum Projects. Fulbright-Hays Summer Seminar Abroad Program 1999 (China).

    ERIC Educational Resources Information Center

    National Committee on United States-China Relations, New York, NY.

    This collection of curriculum projects is the result of the authors' participation in a Fulbright summer seminar program in China. The following 16 curriculum projects are in the collection: (1) "Banpo Village: A Prehistoric Dig" (Sandra Bailey); (2) "China: Moving into the New Millennium: A Study of China's Past, Present and…

  20. Knowledge and Community: The Effect of a First-Year Seminar on Student Persistence

    ERIC Educational Resources Information Center

    Pittendrigh, Adele; Borkowski, John; Swinford, Steven; Plumb, Carolyn

    2016-01-01

    This study explores the effects of an academic seminar on the persistence of first-year college students, including effects on students most at risk of dropping out. A secondary interest was demonstrating the utility of using classification and regression tree analysis to identify relevant predictors of student persistence. The results of the…