Science.gov

Sample records for folding carton seminar

  1. Pollution prevention assessment for a manufacturer of folding paperboard cartons

    SciTech Connect

    Edwards, H.W.; Kostrzewa, M.F.; May, M.; Looby, G.P.

    1995-08-01

    The US Environmental Protection Agency (EPA) has funded a pilot project to assist small and medium-size manufacturers who want to minimize their generation of waste but who lack the expertise to do so. In an effort to assist these manufacturers Waste Minimization Assessment Centers (WMACs) were established at selected universities and procedures were adapted from the EPA Waste Minimization Opportunity Assessment Manual. The WMAC team at Colorado State University performed an assessment at a plant that manufactures folding paperboard cartons. Paperboard stock is cut to specific sheet sizes, printed using a six-color press, cut into carton patterns, folded, and glued. The assessment team`s report detailing findings and recommendations, indicated that waste paperboard is generated in large quantities, and that the most significant cost savings can be achieved through collection and reuse of step 1 solvent used in the printing system. This Research Brief was developed by the principal investigators and EPA`s National Risk Management Research Laboratory, Cincinnati, OH, to announce key findings of an ongoing research project that is fully documented in a separate report of the same title available from University City Science Center.

  2. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  3. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  4. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  5. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE...

  6. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE...

  7. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle cartons, booklets... Requirements for Distilled Spirits § 5.41 Bottle cartons, booklets and leaflets. (a) General. An individual covering, carton, or other container of the bottle used for sale at retail (other than a shipping...

  8. Recycling of aluminum foil from post-consumer beverage cartons

    SciTech Connect

    Charlier, P.; Sjoeberg, G.

    1995-12-31

    Recycling of aluminium contained in used aseptic beverage cartons is a difficult task which has nevertheless to be tackled by modern societies. Techniques have earlier been developed by the paper and pulp industry for the recycling of the board fibers from collected post-consumer beverage cartons. A joint technical feasibility study by Graenges and a leading beverage carton producer has dealt with different techniques for handling residues from repulsing facilities. The aluminium obtained can be used as raw material for the production of thin gauge foil, thus closing the recycling loop.

  9. 1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING SOUTHWEST ALONG MARSEILLES POWER CANAL - National Biscuit Company, Marseilles Factory, Off Main Street on Marseilles Power Canal, Marseilles, La Salle County, IL

  10. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle cartons, booklets... for Wine § 4.38a Bottle cartons, booklets and leaflets. (a) General. An individual covering, carton, or other container of the bottle used for sale at retail (other than a shipping container), or...

  11. Virtual seminars

    NASA Astrophysics Data System (ADS)

    Nelson, H. Roice

    1997-06-01

    A virtual seminar (SM) is an economic and effective instructional tool for teaching students who are at a distance from their instructor. Like conventional class room teaching, a virtual seminar requires an instructor, a student, and a method of communication. Teleconferencing, video conferencing, intranets and the Internet give learners in a Virtual Seminar the ability to interact immediately with their mentors and receive real and relevant answers. This paper shows how industry and academia can benefit from using methods developed and experience gained in presenting the first virtual seminars to academic and petroleum industry participants in mid-1996. The information explosion in industry means that business or technical information is worthless until it is assimilated into a corporate knowledge management system. A search for specific information often turns into a filtering exercise or an attempt to find patterns and classify retrieved material. In the setting of an interactive corporate information system, virtual seminars meet the need for a productive new relationship between creative people and the flux of corporate knowledge. Experience shows that it is more efficient to circulate timesensitive and confidential information electronically through a virtual seminar. Automating the classification of information and removing that task from the usual work load creates an electronic corporate memory and enhances the value of the knowledge to both users and a corporation. Catalogued benchmarks, best-practice standards, and Knowledge Maps (SM) of experience serve as key aids to communicating knowledge through virtual seminars and converting that knowledge into a profit-making asset.

  12. Seminar Software

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Society for Computer Simulation International is a professional technical society that distributes information on methodology techniques and uses of computer simulation. The society uses NETS, a NASA-developed program, to assist seminar participants in learning to use neural networks for computer simulation. NETS is a software system modeled after the human brain; it is designed to help scientists exploring artificial intelligence to solve pattern matching problems. Examples from NETS are presented to seminar participants, who can then manipulate, alter or enhance them for their own applications.

  13. Determination of activation energy of pyrolysis of carton packaging wastes and its pure components using thermogravimetry.

    PubMed

    Alvarenga, Larissa M; Xavier, Thiago P; Barrozo, Marcos Antonio S; Bacelos, Marcelo S; Lira, Taisa S

    2016-07-01

    Many processes have been used for recycling of carton packaging wastes. The pyrolysis highlights as a promising technology to be used for recovering the aluminum from polyethylene and generating products with high heating value. In this paper, a study on pyrolysis reactions of carton packaging wastes and its pure components was performed in order to estimate the kinetic parameters of these reactions. For this, dynamic thermogravimetric analyses were carried out and two different kinds of kinetic models were used: the isoconversional and Independent Parallel Reactions. Isoconversional models allowed to calculate the overall activation energy of the pyrolysis reaction, in according to their conversions. The IPR model, in turn, allowed the calculation of kinetic parameters of each one of the carton packaging and paperboard subcomponents. The carton packaging pyrolysis follows three separated stages of devolatilization. The first step is moisture loss. The second stage is perfectly correlated to devolatilization of cardboard. The third step is correlated to devolatilization of polyethylene.

  14. Nutrient Control Seminars

    EPA Science Inventory

    These Nutrient Control Seminars will present an extensive state-of-the-technology review of the engineering design and operation of nitrogen and phosphorous control technologies and techniques applied at municipal wastewater treatment plants (WWTPs). These seminars will present ...

  15. Food and the purification of society: Dr. Paul Carton and vegetarianism in interwar France.

    PubMed

    Ouedraogo, A P

    2001-08-01

    This article examines the life and work of Dr Paul Carton (1875-1947), a French physician who promoted 'naturist vegetarianism". His career and the evolution of his ideas were influenced by his own experience as a young man of treatment for tuberculosis, and by an anti-materialist philosophy. He developed a diet for his patients that became influential through his writings and through the activities of the French Naturist Society. Although by no means the only advocate of such ideas, Carton's influence has survived and can still be discerned in a close reading of the present-day French popular press.

  16. Mycelial carton galleries of Azteca brevis (Formicidae) as a multi-species network

    PubMed Central

    Mayer, Veronika E.; Voglmayr, Hermann

    2009-01-01

    Apart from growing fungi for nutrition, as seen in the New World Attini, ants cultivate fungi for reinforcement of the walls of their nests or tunnel-shaped runway galleries. These fungi are grown on organic material such as bark, epiphylls or trichomes, and form stable ‘carton structures’. In this study, the carton of the runway galleries built by Azteca brevis (Formicidae, Dolichoderinae) on branches of Tetrathylacium macrophyllum (Flacourtiaceae) is investigated. For the first time, molecular tools are used to address the biodiversity and phylogenetic affinities of fungi involved in tropical ant carton architecture, a previously neglected ant–fungus mutualism. The A. brevis carton involves a complex association of several fungi. All the isolated fungi were unequivocally placed within the Chaetothyriales by DNA sequence data. Whereas five types of fungal hyphae were morphologically distinguishable, our DNA data showed that more species are involved, applying a phylogenetic species concept based on DNA phylogenies and hyphal morphology. In contrast to the New World Attini with their many-to-one (different ant species—one fungal cultivar) pattern, and temperate Lasius with a one-to-two (one ant species—two mutualists) or many-to-one (different ant species share the same mutualist) system, the A. brevis–fungi association is a one-to-many multi-species network. Vertical fungus transmission has not yet been found, indicating that the A. brevis–fungi interaction is rather generalized. PMID:19556257

  17. 78 FR 24211 - Draft Guidance for Industry on Safety Considerations for Container Labels and Carton Labeling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Safety Considerations for Container Labels and Carton Labeling Design To Minimize Medication Errors; Availability AGENCY: Food and... closure design (December 13, 2012, 77 FR 74196), and the third guidance will focus on minimizing...

  18. Equilibrium moisture content of waste mixtures from post-consumer carton packaging.

    PubMed

    Bacelos, M S; Freire, J T

    2012-01-01

    The manufacturing of boards and roof tiles is one of the routes to reuse waste from the recycled-carton-packaging process. Such a process requires knowledge of the hygroscopic behaviour of these carton-packaging waste mixtures in order to guarantee the quality of the final product (e.g. boards and roof tiles). Thus, with four carton-packaging waste mixtures of selected compositions (A, B, C and D), the sorption isotherms were obtained at air temperature of 20, 40 and 60 degrees C by using the static method. This permits one to investigate which model can relate the equilibrium moisture content of the mixture with that of a pure component through the mass fraction of each component in the mixtures. The results show that the experimental data can be well described by the weighted harmonic mean model. This suggests that the mean equilibrium moisture content of the carton-packaging mixture presents a non-linear relationship with each single, pure compound. PMID:22720401

  19. NCEER seminars on earthquakes

    USGS Publications Warehouse

    Pantelic, J.

    1987-01-01

    In May of 1986, the National Center for Earthquake Engineering Research (NCEER) in Buffalo, New York, held the first seminar in its new monthly forum called Seminars on Earthquakes. The Center's purpose in initiating the seminars was to educate the audience about earthquakes, to facilitate cooperation between the NCEER and visiting researchers, and to enable visiting speakers to learn more about the NCEER   

  20. Technical Seminar: "Crash Safety"""

    NASA Video Gallery

    This seminar addresses the history and successful progress in predicting and improving the crash safety characteristics of vehicles, with particular emphasis on rotary wing aircraft and composite s...

  1. Astronomy Research Seminar

    NASA Astrophysics Data System (ADS)

    Johson, Jolyon; Genet, Russell; Armstrong, James; Boyce, Grady; Boyce, Pat; Brewer, Mark; Buchheim, Robert; Carro, Joseph; Estrada, Reed; Estrada, Chris; Freed, Rachel; Gillette, Sean; Harshaw, Richard; Hollis, Thomas; Kenney, John; McGaughey, Seven; McNab, Christine; Mohanan, Kakkala; Sepulveda, Babs; Wallace, Dan; Wallen, Vera

    2015-05-01

    Traditional science lectures and labs are often enhanced through project- and team-based learning. Some students go beyond these classroom studies by conducting research, often under the guidance of university professors. A one-semester astronomy research seminar was initiated in 2006 in collaboration with the community of professional and amateur double star astronomers. The result was dozens of jointly-authored papers published in the Journal of Double Star Observations and the Annual Proceedings of the Society of Astronomical Sciences. This seminar, and its affiliated community, launched a series of conferences and books, providing students with additional forums to share their double star research. The original seminar, and its derivatives, enhanced educational careers through college admissions and scholarships. To expand the seminar's reach, it was restructured from a few teams at one school, to many teams, each from a different school. A volunteer from each school became an assistant instructor. Most of them were seminar veterans, experienced astronomers, or science teachers. The assistant instructors, in turn, recruited enthusiastic students for their teams. To avoid student and instructor overload, the seminar focused on its three deliverables: a formal proposal, published paper, and public PowerPoint presentation. Future seminars may offer other astronomical research options such as exoplanet transit or eclipsing binary photometry.

  2. Situational Communication Skills Seminars

    ERIC Educational Resources Information Center

    Beaupre, Walter J.

    1970-01-01

    Describes a series of seminars held by the University of Rhode Island which attempted to improve communication between local professional persons, deaf adults, and graduate students in speech pathology and audiology. (RW)

  3. Folding Beauties

    ERIC Educational Resources Information Center

    Berman, Leah Wrenn

    2006-01-01

    This article has its genesis in an MAA mini-course on origami, where a way to get a parabola by folding paper was presented. This article discusses the methods and mathematics of other curves obtained by paper-folding.

  4. Extreme Folding

    NASA Astrophysics Data System (ADS)

    Demaine, Erik

    2012-02-01

    Our understanding of the mathematics and algorithms behind paper folding, and geometric folding in general, has increased dramatically over the past several years. These developments have found a surprisingly broad range of applications. In the art of origami, it has helped spur the technical origami revolution. In engineering and science, it has helped solve problems in areas such as manufacturing, robotics, graphics, and protein folding. On the recreational side, it has led to new kinds of folding puzzles and magic. I will give an overview of the mathematics and algorithms of folding, with a focus on new mathematics and sculpture.

  5. Sharing Practice through Socratic Seminars

    ERIC Educational Resources Information Center

    Mangrum, Jennifer R.

    2010-01-01

    Developing systems and opportunities for effective dialogue is critical if schools wish to help teachers work collectively. One school used Socratic seminars, structured conversations about selected texts. These seminars helped teachers to build relationships, share practice, and change curriculum and policy. The seminars also were critical to…

  6. School Budget Seminars.

    ERIC Educational Resources Information Center

    New York State School Boards Association, Albany.

    This report is a compilation of the presentations made at three New York State School Boards Association seminars on school budgets. The programs consisted of presentations on the relationship of the school district's program to the budget and to budget development, timetable, control, and presentation, as well as to other considerations such as…

  7. Discipline Seminar. Report.

    ERIC Educational Resources Information Center

    Carson, Mary R.; And Others

    For three weeks participants in a Seattle (Washington) seminar conducted an intensive review of school discipline problems that included a survey of all staff; a sample survey of students at three shcool levels; five community meetings; presentations by 61 individuals, agencies, or groups; a review of district statistics, practices, and…

  8. [A seminar for thinking?].

    PubMed

    Touzet, Patrick

    2014-01-01

    The sociopolitical context in which we carry out our caregiving profession influences our methods of working. In our world marked by rationalism, thinking about care, in the framework of a seminar, is a way of engaging ourselves and of not simply becoming a functionary of care.

  9. Seminar by Satellite

    ERIC Educational Resources Information Center

    Hart, Peter J.

    1978-01-01

    Seminars on curriculum development transmitted by satellite are operated by the University of the South Pacific, Suva. The satellite was launched in 1966 by NASA, which has permitted educational broadcasting. Ground stations have been set up in eight countries that support the university. Practical aspects of transmission are outlined. (SW)

  10. Technical assessment of processing plants as exemplified by the sorting of beverage cartons from lightweight packaging wastes.

    PubMed

    Feil, A; Thoden van Velzen, E U; Jansen, M; Vitz, P; Go, N; Pretz, T

    2016-02-01

    The recovery of beverage cartons (BC) in three lightweight packaging waste processing plants (LP) was analyzed with different input materials and input masses in the area of 21-50Mg. The data was generated by gravimetric determination of the sorting products, sampling and sorting analysis. Since the particle size of beverage cartons is larger than 120mm, a modified sampling plan was implemented and targeted multiple sampling (3-11 individual samplings) and a total sample size of respectively 1200l (ca. 60kg) for the BC-products and of about 2400l (ca. 120kg) for material-heterogeneous mixed plastics (MP) and sorting residue products. The results infer that the quantification of the beverage carton yield in the process, i.e., by including all product-containing material streams, can be specified only with considerable fluctuation ranges. Consequently, the total assessment, regarding all product streams, is rather qualitative than quantitative. Irregular operation conditions as well as unfavorable sampling conditions and capacity overloads are likely causes for high confidence intervals. From the results of the current study, recommendations can basically be derived for a better sampling in LP-processing plants. Despite of the suboptimal statistical results, the results indicate very clear that the plants show definite optimisation potentials with regard to the yield of beverage cartons as well as the required product purity. Due to the test character of the sorting trials the plant parameterization was not ideal for this sorting task and consequently the results should be interpreted with care.

  11. Fuel cells seminar

    SciTech Connect

    1996-12-01

    This year`s meeting highlights the fact that fuel cells for both stationary and transportation applications have reached the dawn of commercialization. Sales of stationary fuel cells have grown steadily over the past 2 years. Phosphoric acid fuel cell buses have been demonstrated in urban areas. Proton-exchange membrane fuel cells are on the verge of revolutionizing the transportation industry. These activities and many more are discussed during this seminar, which provides a forum for people from the international fuel cell community engaged in a wide spectrum of fuel cell activities. Discussions addressing R&D of fuel cell technologies, manufacturing and marketing of fuel cells, and experiences of fuel cell users took place through oral and poster presentations. For the first time, the seminar included commercial exhibits, further evidence that commercial fuel cell technology has arrived. A total of 205 papers is included in this volume.

  12. Bioanalysis: challenges and solutions seminar.

    PubMed

    Roberts, Andrew

    2011-09-01

    Industry challenges and solutions for bioanalysis were top of the agenda for the Spring Seminar organized by Quotient Bioresearch in Munich, Germany. The seminar was attended by representatives from pharmaceutical and biotechnology organisations across Europe and featured debates and panel discussions from leading industry speakers on new techniques and hot topics, including the latest industry guidelines.

  13. (International seminar on limnology)

    SciTech Connect

    Kimmel, B.L.

    1991-03-05

    The traveler attended the Second Week on Limnology, the second of a four-part series of week-long conferences, which collectively will comprise the International Seminar on Limnology. These conferences are being organized and sponsored by the National Water Commission of Mexico for the purpose of upgrading the limnological knowledge, experience, and international contacts of limnologists, water resources scientists, and engineers in Mexico. This particular meeting focused on limnological research, water resources development, water resources problems, and lake restoration efforts occurring throughout the world. The traveler presented an invited lecture entitled Understanding Reservoirs as Aquatic Ecosystems'' and served as the moderator of a day-long session on Selected Topics.''

  14. Technical assessment of processing plants as exemplified by the sorting of beverage cartons from lightweight packaging wastes.

    PubMed

    Feil, A; Thoden van Velzen, E U; Jansen, M; Vitz, P; Go, N; Pretz, T

    2016-02-01

    The recovery of beverage cartons (BC) in three lightweight packaging waste processing plants (LP) was analyzed with different input materials and input masses in the area of 21-50Mg. The data was generated by gravimetric determination of the sorting products, sampling and sorting analysis. Since the particle size of beverage cartons is larger than 120mm, a modified sampling plan was implemented and targeted multiple sampling (3-11 individual samplings) and a total sample size of respectively 1200l (ca. 60kg) for the BC-products and of about 2400l (ca. 120kg) for material-heterogeneous mixed plastics (MP) and sorting residue products. The results infer that the quantification of the beverage carton yield in the process, i.e., by including all product-containing material streams, can be specified only with considerable fluctuation ranges. Consequently, the total assessment, regarding all product streams, is rather qualitative than quantitative. Irregular operation conditions as well as unfavorable sampling conditions and capacity overloads are likely causes for high confidence intervals. From the results of the current study, recommendations can basically be derived for a better sampling in LP-processing plants. Despite of the suboptimal statistical results, the results indicate very clear that the plants show definite optimisation potentials with regard to the yield of beverage cartons as well as the required product purity. Due to the test character of the sorting trials the plant parameterization was not ideal for this sorting task and consequently the results should be interpreted with care. PMID:26547410

  15. Improving wet and dry strength properties of recycled old corrugated carton (OCC) pulp using various polymers.

    PubMed

    Hamzeh, Yahya; Sabbaghi, Sanaz; Ashori, Alireza; Abdulkhani, Ali; Soltani, Farshid

    2013-04-15

    In this study, the application of different dosages of low and high molecular weights (MW) of chitosan (Ch), cationic starch (CS) and poly vinyl alcohol (PVA) were systematically investigated using old corrugated carton (OCC) furnishes. Various sequences of above-mentioned polymeric additives were also examined to find out the optimal combination for improving both wet and dry tensile strength. For each treatment, 4 handsheets, each having basis weight of 100 g/m(2), were made. In general, the tensile strength of handsheets was significantly affected by the addition of polymeric agents. The enhancing effect of additives on dry tensile property was much higher than wet condition. The results also showed that the tensile strength of the samples made from OCC furnishes were improved upon the addition of high molecular weight chitosan (ChI) compared to the untreated ones (control). The low MW chitosan did not change the properties of handsheets dramatically. Application of polymeric agents moderately decreased the stretch to rupture, however with increasing dosage the stretch was improved. Sequential addition of used polymers showed that triple application of polymers was beneficial to both dry and wet tensile strength, although the effect was larger for dry. The best results in wet and dry tensile strengths were achieved using sequential of PVA-ChI-CS. Sequential addition of oppositely charged polymers forms a macromolecular layered structure of polyelectrolytes. PMID:23544577

  16. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  17. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  18. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  19. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Educational seminars. 6.94... OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars for employees of retailers either at the industry...

  20. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Educational seminars. 6.94... OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars for employees of retailers either at the industry...

  1. Music, Art, Drama, Civilization Seminar.

    ERIC Educational Resources Information Center

    Hampton City School Board, VA.

    This 1-year elective seminar for high school students is to be taught in five units--Introduction, the Ancient World, the Medieval World, the Renaissance, and the Modern World--with emphasis on four basic themes expressed creatively throughout western history: (1) the common man, (2) the individual, (3) religion, and (4) conflict. Instruction on a…

  2. On Seminars, Ritual, and Cowboys.

    ERIC Educational Resources Information Center

    Quantz, Richard A.

    2001-01-01

    Discusses what can be learned about education by studying nontraditional aspects of classrooms, examining discursive traditions associated with social sciences; presenting two interaction patterns found in seminar-style classes whose ritual aspects help resolve dilemmas in commitment to individualism; noting the apparent lack of intellectual…

  3. Geosynchronous Meteorological Satellite Data Seminar

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A seminar was organized by NASA to acquaint the meteorological community with data now available, and data scheduled to be available in the future, from geosynchronous meteorological satellites. The twenty-four papers were presented in three half-day sessions in addition to tours of the Image Display and LANDSAT Processing Facilities during the afternoon of the second day.

  4. Seminar on Usher's Syndrome: Proceedings.

    ERIC Educational Resources Information Center

    Rochester School for the Deaf, NY.

    Summarized are the presentation of M. Vernon and the Comments of primary panelists from a seminar on Usher's Syndrome, a genetic disease involving congenital deafness and progressive loss of vision due to retinitis pigmentosa. The following topics are addressed: genetics today, nature of Usher's Syndrome, symptoms, prevalence, lay diagnosis for…

  5. BAAL/CUP Seminars 2009

    ERIC Educational Resources Information Center

    Cutting, Joan; Murphy, Brona

    2010-01-01

    The seminar, organised by Joan Cutting and Brona Murphy, aimed: (1) to bring together researchers involved in both emergent and established academic corpora (written and spoken) as well as linguists, lecturers and teachers researching in education, be it language teaching, language-teacher training or continuing professional development in…

  6. INTERDISCIPLINARY RESEARCH SEMINAR IN PSYCHOLINGUISTICS.

    ERIC Educational Resources Information Center

    CROOK, DOROTHEA J.; SIMCHES, SEYMOUR O.

    COOPERATION AMONG THE FOREIGN LANGUAGE SPECIALIST, THE PSYCHOLOGIST, AND THE EDUCATION SPECIALIST IS ESSENTIAL TO SUCCESSFUL RESEARCH IN THE QUEST FOR MORE EFFECTIVE METHODS OF LANGUAGE TEACHING. EIGHT PAPERS, PRESENTED AT A TUFTS UNIVERSITY SEMINAR DURING THE SUMMER OF 1961, ARE COLLECTED HERE IN A FINAL REPORT AND RELATE EACH PARTICIPATING…

  7. The Esfahan Seminar: Report of a Regional Seminar on Functional Literacy and Family Planning Education.

    ERIC Educational Resources Information Center

    Burgess, Linda, Comp.

    This report summarizes the discussion emerging from the issues raised at the Esfahan Seminar on Functional Literacy and Family Planning Education. It is divided into six chapters. Chapter I describes the seminar design, pointing out that it was structured to fulfill the major purposes of the Seminar, one of which was to help each participating…

  8. Socialization and the Graduate Seminar. Response to "Rethinking the Graduate Seminar."

    ERIC Educational Resources Information Center

    Schwartz, Martin D.; Tickamyer, Ann R.

    1999-01-01

    Responds to "Rethinking the Graduate Seminar." Addresses topics such as the many styles of teaching in graduate seminars, the role of the instructor, the graduate seminar as part of professional socialization, and socialization for the teacher. Provides suggestions on the article's ideas for dealing with discussion. (CMK)

  9. Proceedings of the Alternate Energy Systems Seminar

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The Alternative Energy Systems Seminar was held on March 30, 1978, and was sponsored jointly be the Southwest District Office of the U.S. Department of Energy and JPL. The seminar was an experiment in information exchange with the aim of presenting, in a single day, status and prospects for a number of advanced energy systems to a diverse, largely nontechnical audience, and to solicit post-seminar responses from that audience as to the seminar's usefulness. The major systems presented are: (1) Solar Photovoltaic; (2) Geothermal; (3) Cogeneration Power; (4) Solar Thermal; (5) Solar Heating and Cooling; (6) Wind Energy; and (7) Systems Considerations.

  10. International Seminar on Publications in Continuing Education.

    ERIC Educational Resources Information Center

    Charters, Alexander N., Ed.; Rivera, William M., Ed.

    Substantive papers presented at the third in a series of international seminars sponsored by Syracuse University are provided in this publication. In addition, a summary of the themes, or issues, as they emerged in the discussion is given. The seminar focused on publications in the professional field of adult education. The papers presented are as…

  11. International Studies Seminar. Grade 9, First Semester.

    ERIC Educational Resources Information Center

    Girton, Robert

    This curriculum guide contains the grade 9 course content of the interdisciplinary International Studies Seminar, conducted at Withrow High School in Cincinnati, Ohio. The seminar, part of the school's International Studies Academy, is an alternative education program which emphasizes global studies as the core of its curriculum. The document…

  12. Public Policy Seminar from a Black Perspective.

    ERIC Educational Resources Information Center

    National Black Child Development Inst., Inc., Washington, DC.

    This report describes the first Public Policy Seminar, sponsored by the Black Child Development Institute in the summer of 1972. The seminar was designed to provide the opportunity for information-sharing, awareness of federal policy making, and a channel for minorities involved in child development at the community level to exert pressure and…

  13. Literature Seminars for Gifted and Talented Students.

    ERIC Educational Resources Information Center

    Dixon, Felicia A.

    1993-01-01

    The literature seminar format meets the needs of gifted students for intellectual challenges, complex curricular experiences, creative research and writing activities, and stimulating interactions. Three seminars conducted in the English curriculum at a special school for gifted students are described: "Dickens and the Industrial…

  14. VOLATILE ORGANIC COMPOUNDS (VOC) RECOVERY SEMINAR

    EPA Science Inventory

    The purpose of the seminar was to bring researchers, technology developers, and industry representatives together to discuss recovery technologies and techniques for VOCs. The seminar focused on the specific VOC recovery needs of industry and on case studies that summarize effec...

  15. THE COMMUNITY RESOURCES POOL SEMINAR DESCRIPTIONS.

    ERIC Educational Resources Information Center

    SATURDAY MORNING SEMINARS FOR ELEMENTARY AND SECONDARY SCHOOL STUDENTS WERE CONDUCTED WITH PROFESSIONAL RESOURCE PERSONS AS TEACHERS. THE PROGRAM WAS VOLUNTARY. THREE 9-WEEK SEMINARS WERE CONDUCTED IN THE FALL. SUBJECTS STUDIED WERE MICROBIOLOGY AND ZOOLOGY (6TH GRADE), COMPUTER MATH (7TH AND 8TH GRADE), AND CHEMISTRY (GRADES 9-12). DURING THE…

  16. A Program Evaluation of a Seminar Program

    ERIC Educational Resources Information Center

    Lyons, Robert Dale, Jr.

    2013-01-01

    When students do not score well on standardized tests, their school can suffer. In an attempt to improve standardized test scores, a district placed students into a program called Seminar to help them work on weak areas of content through personalized instruction. The purpose of this project study was to assess if the Seminar program had a…

  17. Evaluating a Seminar on Stress Management.

    ERIC Educational Resources Information Center

    Deffenbacher, Jerry L.; Shepard, Jeffrey M.

    1989-01-01

    Examines a college seminar's capacity to reduce stress by evaluating a psychology seminar on stress management over a six-year period. Students reported significantly less general anxiety, general anger, situational stress reactivity, and stress-related physiological reactivity after taking the class. Follow-ups of two classes indicated…

  18. USEPA SEMINARS ON INDOOR AIR VAPOR INTRUSION

    EPA Science Inventory

    This interactive CD has been developed to introduce you to the seminar speakers and their presentation topics. It includes introduction and overview video clips, an interactive class exercise that explains how to interpret and use the new EPA IAVI Guidance, a scrolling seminar vi...

  19. Seminar on Egypt population policy.

    PubMed

    Kantner, J F

    1984-01-01

    The information and viewpoints presented at the Seminar on Egypt Population Policy held in Cairo on October 16-18 were summariezed and critically assessed. The seminar was organized by the International Union for the Scientific Study of Population's Committee on the Utilization ofDemographic Knowlege in Policy Formulation and Planning for the purpose of assessing the policy making the utility of social science and demographc knowledge with specific reference to Egypt's family planning program. The seminar was attended by demographers, social scientists, and experienced policy makers, and the discussion was highly focused. Seminar papers and discussions sought to clarify Egypt's current demographic situation, attempted to use sample survey data to identifyfertility determinants, analyzed Egypt's policyresponses to the population problem, assessed the national family planning program, identified the type of knowledge available for policy making, and noted areas where policy relevant information is lacking. Evidence presented at the seminar indicated that Egyptian fertility is still high and that corrected the total fertility rate for 1980 was close to 6. Since, 1960, fertility declined in all regions of the country, but between 1976-80 the decline decelerated. This deceleration appears to be a temporary phenonemon. There is evidence that the age at marriage is increasing, that the population is motivated to use contraception when desired family size is reached, that contraceptive use is cost sensitive, and that the overall decline in fertility since the 1960s occurred in all parts of the country. Papers which presented analyses of fertility determinants, based on sample survey data, provided little useful insight for policy formulation. The studies indicate that the impact of family planning services on different segments of the population varies, and that these impacts may be increased if social and economic development persists. The preception of the population

  20. Progress in fold recognition.

    PubMed

    Flöckner, H; Braxenthaler, M; Lackner, P; Jaritz, M; Ortner, M; Sippl, M J

    1995-11-01

    The prediction experiment reveals that fold recognition has become a powerful tool in structural biology. We applied our fold recognition technique to 13 target sequences. In two cases, replication terminating protein and prosequence of subtilisin, the predicted structures are very similar to the experimentally determined folds. For the first time, in a public blind test, the unknown structures of proteins have been predicted ahead of experiment to an accuracy approaching molecular detail. In two other cases the approximate folds have been predicted correctly. According to the assessors there were 12 recognizable folds among the target proteins. In our postprediction analysis we find that in 7 cases our fold recognition technique is successful. In several of the remaining cases the predicted folds have interesting features in common with the experimental results. We present our procedure, discuss the results, and comment on several fundamental and technical problems encountered in fold recognition.

  1. Let Them Fold

    ERIC Educational Resources Information Center

    Grant, Nicholas; Tobin, Alexander

    1972-01-01

    Directions are given for seven activities involving the folding of paper strips to illustrate geometric concepts. Properties of pentagons, triangles, hexagons, and Mobius bands resulting from the various foldings are discussed. (DT)

  2. High Diversity and Low Specificity of Chaetothyrialean Fungi in Carton Galleries in a Neotropical Ant–Plant Association

    PubMed Central

    Nepel, Maximilian; Voglmayr, Hermann; Schönenberger, Jürg; Mayer, Veronika E.

    2014-01-01

    New associations have recently been discovered between arboreal ants that live on myrmecophytic plants, and different groups of fungi. Most of the – usually undescribed – fungi cultured by the ants belong to the order Chaetothyriales (Ascomycetes). Chaetothyriales occur in the nesting spaces provided by the host plant, and form a major part of the cardboard-like material produced by the ants for constructing nests and runway galleries. Until now, the fungi have been considered specific to each ant species. We focus on the three-way association between the plant Tetrathylacium macrophyllum (Salicaceae), the ant Azteca brevis (Formicidae: Dolichoderinae) and various chaetothyrialean fungi. Azteca brevis builds extensive runway galleries along branches of T. macrophyllum. The carton of the gallery walls consists of masticated plant material densely pervaded by chaetothyrialean hyphae. In order to characterise the specificity of the ant–fungus association, fungi from the runway galleries of 19 ant colonies were grown as pure cultures and analyzed using partial SSU, complete ITS, 5.8S and partial LSU rDNA sequences. This gave 128 different fungal genotypes, 78% of which were clustered into three monophyletic groups. The most common fungus (either genotype or approximate species-level OTU) was found in the runway galleries of 63% of the investigated ant colonies. This indicates that there can be a dominant fungus but, in general, a wider guild of chaetothyrialean fungi share the same ant mutualist in Azteca brevis. PMID:25398091

  3. A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials.

    PubMed

    Koster, Sander; Rennen, Monique; Leeman, Winfried; Houben, Geert; Muilwijk, Bas; van Acker, Frederique; Krul, Lisette

    2014-01-01

    One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples. PMID:24237267

  4. High diversity and low specificity of chaetothyrialean fungi in carton galleries in a neotropical ant-plant association.

    PubMed

    Nepel, Maximilian; Voglmayr, Hermann; Schönenberger, Jürg; Mayer, Veronika E

    2014-01-01

    New associations have recently been discovered between arboreal ants that live on myrmecophytic plants, and different groups of fungi. Most of the - usually undescribed - fungi cultured by the ants belong to the order Chaetothyriales (Ascomycetes). Chaetothyriales occur in the nesting spaces provided by the host plant, and form a major part of the cardboard-like material produced by the ants for constructing nests and runway galleries. Until now, the fungi have been considered specific to each ant species. We focus on the three-way association between the plant Tetrathylacium macrophyllum (Salicaceae), the ant Azteca brevis (Formicidae: Dolichoderinae) and various chaetothyrialean fungi. Azteca brevis builds extensive runway galleries along branches of T. macrophyllum. The carton of the gallery walls consists of masticated plant material densely pervaded by chaetothyrialean hyphae. In order to characterise the specificity of the ant-fungus association, fungi from the runway galleries of 19 ant colonies were grown as pure cultures and analyzed using partial SSU, complete ITS, 5.8S and partial LSU rDNA sequences. This gave 128 different fungal genotypes, 78% of which were clustered into three monophyletic groups. The most common fungus (either genotype or approximate species-level OTU) was found in the runway galleries of 63% of the investigated ant colonies. This indicates that there can be a dominant fungus but, in general, a wider guild of chaetothyrialean fungi share the same ant mutualist in Azteca brevis. PMID:25398091

  5. A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials.

    PubMed

    Koster, Sander; Rennen, Monique; Leeman, Winfried; Houben, Geert; Muilwijk, Bas; van Acker, Frederique; Krul, Lisette

    2014-01-01

    One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples.

  6. Increasing Effectiveness of Strategic Planning Seminars through Learning Style

    ERIC Educational Resources Information Center

    Yildirim, Nail

    2010-01-01

    This research tests the effectiveness of taking learning style variables from the Kolb learning model in designing strategic planning seminars. We observe in our research that the participants in the seminar--school principals--positively judge the effectiveness of the seminar. The research also tests the seminar's effectiveness in terms of the…

  7. Senior Seminar: Across a Department and across The Years

    ERIC Educational Resources Information Center

    Greer, Meredith L.; Ross, Chip

    2013-01-01

    The Department of Mathematics at Bates College has offered a senior seminar capstone course for over a dozen years. In this article, we discuss the coexistence of seminar and thesis, our other capstone experience. We discuss in detail the goals of our seminar, various ways we structure the seminar to accomplish those goals, and methods of…

  8. Induction Seminars as Professional Learning Communities for Beginning Teachers

    ERIC Educational Resources Information Center

    Fresko, Barbara; Nasser-Abu Alhija, Fadia

    2015-01-01

    This paper explores the operation and contribution of induction seminars operated as learning communities for new teachers. Mixed methods were used: 378 new teachers and 29 seminar leaders completed questionnaires, 16 new teachers and 14 seminar leaders were interviewed, and 20 seminar meetings were observed. Findings showed that seminar…

  9. Public Relations Guide. Featuring PR Tools, PR Techniques, How To Set Up a PR Seminar. Revised Edition.

    ERIC Educational Resources Information Center

    Procter and Gamble Educational Services, Cincinnati, OH.

    The goal of this guide is two-fold: (1) to equip readers with practical guidelines for establishing communications plans and making those plans work; and (2) to develop information for implementing a public relations seminar targeted at designing workshops that reach a broad segment of members. Five topics are addressed: (1) the basic public…

  10. SEMINAR PROCEEDINGS: RCRA CORRECTIVE ACTION STABILIZATION TECHNOLOGIES

    EPA Science Inventory

    The seminar publication provides an overview of many technologies that can be used in applying the stabilization concept to RCRA cleanup activities. Technologies discussed include covers, grouting, slurry walls, hydrofracture, horizontal well drilling, a vacuum extraction, and b...

  11. Technical Seminar: "Trajectory-Based Operations"""

    NASA Video Gallery

    A safe and efficient air traffic management system is vital to the nation's economy. This seminar explores the concepts and current research into air traffic control concepts that focus on more dim...

  12. Hilbert at Vassar: An Undergraduate Seminar.

    ERIC Educational Resources Information Center

    Feroe, John A.

    1978-01-01

    A description is given of a senior seminar in which each student reported on a topic centered around the works of David Hilbert. A brief description of each topic is given as well as a list of references. (MP)

  13. Provocative Questions in Cancer: NCI Seminar

    Cancer.gov

    science writers' seminar to discuss various aspects of one of NCI’s signature efforts -- the Provocative Questions project. Discussion will focus on the scientific research that surrounds some of these questions.

  14. NASA Seminar on Organization and Management

    NASA Technical Reports Server (NTRS)

    Crawley, R. W.; Kloman, E. H.

    1972-01-01

    The proceedings of a seminar series of current problems and organization of NASA are presented. The seminar was designed to provide a comparative basis for understanding such recurring problems as delegation of authority, resource allocation and decision making patterns, headquarters organization, systems of program control and evaluation, roles and relations of scientists, engineers, and administrators, headquarters-field center relationships, and the overall management philosophy of the headquarters and field centers.

  15. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2012-10-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold distribution procedure. The fold distribution provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of change in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Distribution, Proposal 12778, as Cycle 19.

  16. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2010-09-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis {11863} during Cycle 17.

  17. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2009-07-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis {10035} during Cycle 12.

  18. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2013-10-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold distribution procedure. The fold distribution provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of change in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Distribution, Proposal 13149, as Cycle 20.

  19. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2011-10-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis, Proposal 12416, as Cycle 18.

  20. Fast protein folding kinetics

    PubMed Central

    Gelman, Hannah; Gruebele, Martin

    2014-01-01

    Fast folding proteins have been a major focus of computational and experimental study because they are accessible to both techniques: they are small and fast enough to be reasonably simulated with current computational power, but have dynamics slow enough to be observed with specially developed experimental techniques. This coupled study of fast folding proteins has provided insight into the mechanisms which allow some proteins to find their native conformation well less than 1 ms and has uncovered examples of theoretically predicted phenomena such as downhill folding. The study of fast folders also informs our understanding of even “slow” folding processes: fast folders are small, relatively simple protein domains and the principles that govern their folding also govern the folding of more complex systems. This review summarizes the major theoretical and experimental techniques used to study fast folding proteins and provides an overview of the major findings of fast folding research. Finally, we examine the themes that have emerged from studying fast folders and briefly summarize their application to protein folding in general as well as some work that is left to do. PMID:24641816

  1. A galaxy of folds.

    PubMed

    Alva, Vikram; Remmert, Michael; Biegert, Andreas; Lupas, Andrei N; Söding, Johannes

    2010-01-01

    Many protein classification systems capture homologous relationships by grouping domains into families and superfamilies on the basis of sequence similarity. Superfamilies with similar 3D structures are further grouped into folds. In the absence of discernable sequence similarity, these structural similarities were long thought to have originated independently, by convergent evolution. However, the growth of databases and advances in sequence comparison methods have led to the discovery of many distant evolutionary relationships that transcend the boundaries of superfamilies and folds. To investigate the contributions of convergent versus divergent evolution in the origin of protein folds, we clustered representative domains of known structure by their sequence similarity, treating them as point masses in a virtual 2D space which attract or repel each other depending on their pairwise sequence similarities. As expected, families in the same superfamily form tight clusters. But often, superfamilies of the same fold are linked with each other, suggesting that the entire fold evolved from an ancient prototype. Strikingly, some links connect superfamilies with different folds. They arise from modular peptide fragments of between 20 and 40 residues that co-occur in the connected folds in disparate structural contexts. These may be descendants of an ancestral pool of peptide modules that evolved as cofactors in the RNA world and from which the first folded proteins arose by amplification and recombination. Our galaxy of folds summarizes, in a single image, most known and many yet undescribed homologous relationships between protein superfamilies, providing new insights into the evolution of protein domains. PMID:19937658

  2. United States Savings Bonds Seminar: Seminar Leader's Guide. 3rd Edition.

    ERIC Educational Resources Information Center

    Department of the Treasury, Washington, DC.

    This leader's guide is designed for use in conducting a seminar to train bank employees in correct procedures for issuing and redeeming U.S. Savings Bonds and in answering routine customer inquiries concerning savings bonds. Included in the first section of the guide are an overview of the purpose and content of the seminar, procedures for…

  3. Mathematics Through Paper Folding.

    ERIC Educational Resources Information Center

    Olson, Alton T.

    This booklet is a revised edition of Donovan Johnson's "Paper Folding for the Mathematics Class" (ED 077 711). It begins with directions for folding basic constructions such as as a straight line, the line perpendicular to a given line passing through a given point, and the bisector of an angle. Subsequent chapters cover concepts related to…

  4. Folding by Design

    NASA Astrophysics Data System (ADS)

    Dodd, Paul; Damasceno, Pablo; Glotzer, Sharon

    2014-03-01

    A form of self-assembly, ``self-folding'' presents an alternative approach to the creation of reconfigurable, responsive materials with applications ranging from robotics to drug design. However, the complexity of interactions present in biological and engineered systems that undergo folding makes it challenging to isolate the main factors controlling their assembly and dis-assembly. Here we use computer simulations of simple, minimalistic self-foldable structures and investigate their stochastic folding process. By dynamically accessing all the states that lead to, or inhibit, successful folding, we show that the mechanisms by which general stochastic systems can achieve their ``native'' structures can be identified and used to design rules for optimized folding propensity. Research supported by the National Science Foundation, Emerging Frontiers in Research and Innovation Award # EFRI-1240264.

  5. Freshman Seminars: Interdisciplinary Engagements in Astronomy

    NASA Astrophysics Data System (ADS)

    Hemenway, M. K.

    2006-08-01

    The Freshman Seminar program at the University of Texas is designed to allow groups of fifteen students an engaging introduction to the University. The seminars introduce students to the resources of the university and allow them to identify interesting subjects for further research or future careers. An emphasis on oral and written communication by the students provides these first-year students a transition to college-level writing and thinking. Seminar activities include field trips to an art museum, a research library, and the Humanities Research Center rare book collection. This paper will report on two seminars, each fifteen weeks in length. In "The Galileo Scandal" students examine Galileo's struggle with the church (including a mock trial). They perform activities that connect his use of the telescope and observations to astronomical concepts. In "Astronomy and the Humanities" students analyze various forms of human expression that have astronomical connections (art, drama, literature, music, poetry, and science fiction); they perform hands-on activities to reinforce the related astronomy concepts. Evaluation of the seminars indicates student engagement and improvement in communication skills. Many of the activities could be used independently to engage students enrolled in standard introductory astronomy classes.

  6. Origin of Permian andesites from Xi Ujimqin, the Hinggan Mountains: Contributions of lower crust North China Carton

    NASA Astrophysics Data System (ADS)

    Gao, X.

    2014-12-01

    Andesite magmas at convergent margins are enriched in silica compared to magmas erupting at mid-ocean ridges and intra-plate volcanoes. Determining the cause (s) of silica enrichment is fundamental for models of continental crust formation, arc growth rates and across-arc mass balances (Plank and Langmuir, 1993; Rudnick, 1995; White et al., 2006).The Xi-Ujimqin is located the eastern segment of the Central Asian Orogenic Belt , the CAOB is composed of mainly subduction-accretion complexes, intruded by vast plutons of mainly magmatic arc origin and covered in places by their volcanic derivatives (Sengor et al. 1993; Sengor and Natalin 1996). As the most important site for Phanerozoic crustal growth in the world, the subduction-accretion complexes added ~ 5.3 million km2of material to Asia, half of which may be of juvenile origin (Sengor et al. 1993).The andesitic lavas of Daotenuoer Fms. at Xi-Ujimqin have different trace and Sr-Nd-Pb isotopic characteristic from them, these rocks span a SiO2 range of 56.83 ~ 59.17% and MgO of range of 1.21~2.91%, characterized by obviously LREE/HREE fractionation (Ce/YbCN = 11.6 ~ 16.8), strong LILE enrichment and variable Nb-Ta and Sr depletion. They have more radiogenic Sr and less radiogenic Nd and Pb isotopic composition (87Sr/86Sr(i) = 0.7063 ~ 0.7066, eNd(t) = -10.5 ~ -6.3,TDM = 1.22 ~ 1.51Ga, 206Pb / 204Pb(i) = 17.29 ~ 17.33, D7/4 = 3.7 ~ 6.9, D 8/4 = 94 ~ 104) than the contemporaneous intermediate-felsic volcanic lavas. Zircon U-Pb dating results give an emplacement age of ~253 Ma for the these rocks by LA-ICP-MS, corresponding to the Late Permian. The features of major, trace and Sr-Nd-Pb isotope of These rocks imply its sources are of attributes of lower crust North China Carton (NCC) during Paleozoic subduction and collision related to the closure of the Chinese segment of the Paleo-Asian Ocean between the NCC and south Mongolia Block (Sengor et al., 1993).

  7. NUV MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2009-07-01

    The performance of MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS SMOV as proposal 13555 {visit 5}.

  8. Fulbright-Hays Seminars Abroad Program and Special Bilateral Projects

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The Fulbright-Hays Seminars Abroad Program and Special Bilateral Projects provides short-term study and travel seminars abroad for U.S. educators in the social sciences and humanities for the purpose of improving their understanding and knowledge of the people and culture of other countries. There are approximately 10 seminars with 16 participants…

  9. Whither Thou Goest: The Intrigue of an International Study Seminar.

    ERIC Educational Resources Information Center

    Patten, Ronald J.; Peters, Robert

    This paper describes one business school's response to the challenges of globalization. After faculty members taught seminars in other countries, an interest was expressed in conducting international study seminars for the school's business students. One-week seminars were arranged, which allowed part-time, employed MBA students to enroll. The…

  10. Seminar for Master's Thesis Projects: Promoting Students' Self-Regulation

    ERIC Educational Resources Information Center

    Miedijensky, Shirley; Lichtinger, Einat

    2016-01-01

    This study presents a thesis seminar model aimed at promoting students' self-regulation. Students' perceptions regarding the contribution of the seminar to their learning process were characterized and the seminar's effect upon their self-regulation expressions was examined. Data was collected using questionnaires and analyzed thematically. The…

  11. Reviving Graduate Seminar Series through Non-Technical Presentations

    ERIC Educational Resources Information Center

    Madihally, Sundararajan V.

    2011-01-01

    Most chemical engineering programs that offer M.S. and Ph.D. degrees have a common seminar series for all the graduate students. Many would agree that seminars lack student interest, leading to ineffectiveness. We questioned the possibility of adding value to the seminar series by incorporating non-technical topics that may be more important to…

  12. POS 591: International Relations Seminar "The Modern World-System."

    ERIC Educational Resources Information Center

    McGowan, Patrick J.

    The syllabus outlines a college level international relations seminar with a neo-Marxist theoretical orientation. The objective of the seminar is to present an historical and comparative approach to a study of the evolution of the international political economy. Following an introduction explaining seminar objectives, grading, and course…

  13. Should We Bother Improving Students' Attendance at Seminars?

    ERIC Educational Resources Information Center

    Gbadamosi, Gbolahan

    2015-01-01

    This study uses action research intervention to improve students' attendance at seminars. Specifically, the study asks the question: will students' attendance improve if they drive their own learning by running their own seminars? Records of lecture and seminar attendance at a module and comparative ones were used. Focus group interviews…

  14. Folding without charges

    PubMed Central

    Kurnik, Martin; Hedberg, Linda; Danielsson, Jens; Oliveberg, Mikael

    2012-01-01

    Surface charges of proteins have in several cases been found to function as “structural gatekeepers,” which avoid unwanted interactions by negative design, for example, in the control of protein aggregation and binding. The question is then if side-chain charges, due to their desolvation penalties, play a corresponding role in protein folding by avoiding competing, misfolded traps? To find out, we removed all 32 side-chain charges from the 101-residue protein S6 from Thermus thermophilus. The results show that the charge-depleted S6 variant not only retains its native structure and cooperative folding transition, but folds also faster than the wild-type protein. In addition, charge removal unleashes pronounced aggregation on longer timescales. S6 provides thus an example where the bias toward native contacts of a naturally evolved protein sequence is independent of charges, and point at a fundamental difference in the codes for folding and intermolecular interaction: specificity in folding is governed primarily by hydrophobic packing and hydrogen bonding, whereas solubility and binding relies critically on the interplay of side-chain charges. PMID:22454493

  15. Teachers’ perceptions of aspects affecting seminar learning: a qualitative study

    PubMed Central

    2013-01-01

    Background Many medical schools have embraced small group learning methods in their undergraduate curricula. Given increasing financial constraints on universities, active learning groups like seminars (with 25 students a group) are gaining popularity. To enhance the understanding of seminar learning and to determine how seminar learning can be optimised it is important to investigate stakeholders’ views. In this study, we qualitatively explored the views of teachers on aspects affecting seminar learning. Methods Twenty-four teachers with experience in facilitating seminars in a three-year bachelor curriculum participated in semi-structured focus group interviews. Three focus groups met twice with an interval of two weeks led by one moderator. Sessions were audio taped, transcribed verbatim and independently coded by two researchers using thematic analysis. An iterative process of data reduction resulted in emerging aspects that influence seminar learning. Results Teachers identified seven key aspects affecting seminar learning: the seminar teacher, students, preparation, group functioning, seminar goals and content, course coherence and schedule and facilities. Important components of these aspects were: the teachers’ role in developing seminars (‘ownership’), the amount and quality of preparation materials, a non-threatening learning climate, continuity of group composition, suitability of subjects for seminar teaching, the number and quality of seminar questions, and alignment of different course activities. Conclusions The results of this study contribute to the unravelling of the ‘the black box’ of seminar learning. Suggestions for ways to optimise active learning in seminars are made regarding curriculum development, seminar content, quality assurance and faculty development. PMID:23399475

  16. 2012 National Policy Seminar Wrap-Up

    ERIC Educational Resources Information Center

    Blandford, Ayoka

    2012-01-01

    CTE works! That was the recurring theme that attendees heard at the 2012 National Policy Seminar (NPS) hosted by ACTE. For those new to the event and lobbying, a pre-conference workshop, "Learning the Ropes of Washington CTE Advocacy," laid out the basics of Hill advocacy. Veteran CTE advocates were offered a basics-plus session, "Tailoring Your…

  17. NASA STI Program Seminar: Electronic documents

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The theme of this NASA Scientific and Technical Information Program Seminar was electronic documents. Topics covered included Electronic Documents Management at the CASI, the Impact of Electronic Publishing on User Expectations and Searching Image Record Management, Secondary Publisher Considerations for Electronic Journal Literature, and the Technical Manual Publishing On Demand System (TMPODS).

  18. The International Negotiation Seminars Project. Project ICONS.

    ERIC Educational Resources Information Center

    Wilkenfeld, Jonathan; Kaufman, Joyce; Starkey, Brigid

    This report of a study at the University of Maryland describes an international, interactive, and interdisciplinary project for first- and second-year students, which combines a large lecture format with small-group, seminar-type sessions organized around a computer-assisted simulation model, the International Communication and Negotiation…

  19. LEADERSHIP DEVELOPMENT SEMINAR, VOCATIONAL-TECHNICAL EDUCATION.

    ERIC Educational Resources Information Center

    BEALL, MIRIAM L.; SMITH, CLODUS R.

    FORTY-FIVE VOCATIONAL EDUCATORS PARTICIPATED IN A SEMINAR DESIGNED TO DEVELOP UNDERSTANDINGS, ABILITIES, AND ATTITUDES FOR MORE EFFECTIVE LEADERSHIP BY PROFESSIONAL STATE-LEVEL VOCATIONAL EDUCATION PERSONNEL IN 23 EASTERN STATES, THE DISTRICT OF COLUMBIA, PUERTO RICO, AND THE VIRGIN ISLANDS. SUMMARIES OF THE FOLLOWING PRESENTATIONS ARE INCLUDED…

  20. PRAGUE SEMINAR ON LANGUAGE TEACHING AIMS, 1967.

    ERIC Educational Resources Information Center

    FRIED, VILEM

    AN INTERNATIONAL SEMINAR, WHOSE PURPOSE IT WAS TO DISCUSS THE STRUCTURAL DIFFERENCES IN LANGUAGE TEACHING AIMS, IS REPORTED ON IN THIS ARTICLE. THE THREE PAPERS PRESENTED BY IVAN POLDAUF, VALENTINA ZETLINA, AND JOHN B. CARROLL ARE REVIEWED FOR THEIR DISCUSSIONS ON LINGUISTICS, DIDACTICS, AND PSYCHOLOGY. THE DISCUSSION FOLLOWING THE PRESENTATION OF…

  1. Psychological Education. Middle School Seminar Series.

    ERIC Educational Resources Information Center

    Georgia State Dept. of Education, Atlanta. Office of Planning and Development.

    This leader's guide, the first of three in a series for middle school students, presents a program designed to develop interpersonal skills and self-understanding. The guide is organized into three major seminars: communication, understanding behavior, and changing behavior; these are sequential and hierarchical in nature. Specific instructions…

  2. Report on Fulbright Summer Seminar on Indonesia.

    ERIC Educational Resources Information Center

    Christenson, Charles Elroy

    This resource packet was compiled by a participant in the Fulbright Summer Seminar on Indonesia. The materials provide information for teaching about the diaspora of Hinduism and Islamic beliefs throughout the southeast Asia archipelagoes and their influence on art and culture. The handouts supplement information on Indonesia as part of an Asian…

  3. Proceedings: EPRI Second Phased Array Inspection Seminar

    SciTech Connect

    2001-11-01

    The Second EPRI Phased Array Inspection Seminar focused on industrial applications of phased array technology that have been achieved to date or are planned for the near future. Presentations were made by developers of inspection techniques, inspection services vendors, and utility personnel who have performed inspections using arrays.

  4. Latin American USOMs Seminar on Agrarian Reform.

    ERIC Educational Resources Information Center

    International Cooperation Administration (Dept. of State), Washington, DC.

    This report of seminar proceedings discusses land reform policies and programs and their place in the economic development of Latin America. It analyzes experiences and current situations in Latin America, the United States, and elsewhere which shed light on the problems and possibilities of agrarian reform. An appraisal of existing physical,…

  5. Seminar "Quantum Gravity' (Moscow, May 1987). Recollections

    NASA Astrophysics Data System (ADS)

    Gaina, Alex

    2008-08-01

    A short story of the Seminar "Quantum Gravity' (Moscow, May 1987) is given with recollections about few meetings with professors: M.A. Markov, John Archibald Wheeler, Gert T'Hooft, Ya. B.Zeldovich, Stephen Hawking, A.D. Sakharov, Garry Gibbons, Cecille and Bryce DeWitt, Ph. Candelas, L.P.Grishchuk, A.D. Linde and other.

  6. Senior Seminars: Focus on the Future

    ERIC Educational Resources Information Center

    Dreis, Janice; Rehage, Larry

    2010-01-01

    Senior year is the perfect time to offer students challenges that will help prepare them for life after school. The term "senior seminar" has been commonly used to describe a course that is specifically designed to help 12th graders develop knowledge, skills, and habits of mind that will prepare them for their college or work experiences. Senior…

  7. Focus Group Report: Seminar in College Teaching.

    ERIC Educational Resources Information Center

    Chang, Glenna C.; And Others

    This paper presents the report of a University of Maryland focus group evaluating a seminar in teaching designed for undergraduate teaching fellows in engineering. The course's purpose was to provide the fellows the opportunity to apply teaching theory to practice. Focus groups were conducted in order to evaluate the course and the teaching…

  8. Folds and Etudes

    ERIC Educational Resources Information Center

    Bean, Robert

    2007-01-01

    In this article, the author talks about "Folds" and "Etudes" which are images derived from anonymous typing exercises that he found in a used copy of "Touch Typing Made Simple". "Etudes" refers to the musical tradition of studies for a solo instrument, which is a typewriter. Typing exercises are repetitive attempts to type words and phrases…

  9. Modelling of lateral fold growth and fold linkage: Applications to fold-and-thrust belt tectonics

    NASA Astrophysics Data System (ADS)

    Grasemann, Bernhard; Schmalholz, Stefan

    2013-04-01

    We use a finite element model to investigate the three-dimensional fold growth and interference of two initially isolated fold segments. The most critical parameter, which controls the fold linkage mode, is the phase difference between the laterally growing fold hinge lines: 1) "Linear-linkage" yields a sub-cylindrical fold with a saddle at the location where the two initial folds linked. 2) "Oblique-linkage" produces a curved fold resembling a Type II refold structure. 3) "Oblique-no-linkage" results in two curved folds with fold axes plunging in opposite directions. 4) "Linear-no-linkage" yields a fold train of two separate sub-cylindrical folds with fold axes plunging in opposite directions. The transition from linkage to no-linkage occurs when the fold separation between the initially isolated folds is slightly larger than one half of the low-amplitude fold wavelength. The model results compare well with previously published plasticine analogue models and can be directly applied to the investigation of fold growth history in fold-and-thust belts. An excellent natural example of lateral fold linkage is described from the Zagros fold-and-thrust belt in the Kurdistan Region of Iraq. The fold growth in this region is not controlled by major thrust faults but the shortening of the Paleozoic to Cenozoic passive margin sediments of the Arabian plate occurred mainly by detachment folding. The sub-cylindrical anticlines with hinge-parallel lengths of more than 50 km have not developed from single sub-cylindrical embryonic folds but they have merged from different fold segments that joined laterally during fold amplification and lateral fold growth. Linkage points are marked by geomorphological saddle points which are structurally the lowermost points of antiforms and points of principal curvatures with opposite sign. Linkage points can significantly influence the migration of mineral-rich fluids and hydrocarbons and are therefore of great economic importance.

  10. Oxidative folding: recent developments.

    PubMed

    Szarka, András; Bánhegyi, Gábor

    2011-10-01

    Disulfide bond formation in proteins is an effective tool of both structure stabilization and redox regulation. The prokaryotic periplasm and the endoplasmic reticulum of eukaryotes were long considered as the only compartments for enzyme mediated formation of stable disulfide bonds. Recently, the mitochondrial intermembrane space has emerged as the third protein-oxidizing compartment. The classic view on the mechanism of oxidative folding in the endoplasmic reticulum has also been reshaped by new observations. Moreover, besides the structure stabilizing function, reversible disulfide bridge formation in some proteins of the endoplasmic reticulum, seems to play a regulatory role. This review briefly summarizes the present knowledge of the redox systems supporting oxidative folding, emphasizing recent developments. PMID:25962043

  11. Assessment of cancer education seminars for Appalachian populations.

    PubMed

    Katz, Mira L; Pennell, Michael L; Dignan, Mark B; Paskett, Electra D

    2012-06-01

    Cancer education seminars for Appalachian populations were conducted to: (1) increase knowledge of existing cancer disparities, (2) disseminate findings from Appalachian community-based participatory research (CBPR) projects, and (3) foster CBPR capacity building among community members by promoting social networking. Evaluation of the seminars was completed by: (1) using pre-post-surveys to assess changes in knowledge and attitudes at three regional and one national seminar and (2) measuring a change in the social network patterns of participants at a national seminar by analyzing the names of individuals known at the beginning and at the end of the seminar by each participant. Among participants, there was a significant increase in knowledge of Appalachian cancer disparities at two seminars [national, t(145) = 3.41, p = 0.001; Pennsylvania, t(189) = 3.00, p = 0.003] and a change in attitudes about Appalachia at one seminar [Ohio t(193) = -2.80, p = 0.006]. Social network analysis, operationally defined for this study as familiarity with individuals attending the conference, showed participation in the national seminar fostered capacity building for future CBPR by the development of new network ties. Findings indicate that short-term outcomes of the seminars were accomplished. Future educational seminars should consider using social network analysis as a new evaluation methodology.

  12. The protein folding network

    NASA Astrophysics Data System (ADS)

    Rao, Francesco; Caflisch, Amedeo

    2004-03-01

    Networks are everywhere. The conformation space of a 20-residue antiparallel beta-sheet peptide [1], sampled by molecular dynamics simulations, is mapped to a network. Conformations are nodes of the network, and the transitions between them are links. As previously found for the World-Wide Web as well as for social and biological networks , the conformation space contains highly connected hubs like the native state which is the most populated free energy basin. Furthermore, the network shows a hierarchical modularity [2] which is consistent with the funnel mechanism of folding [3] and is not observed for a random heteropolymer lacking a native state. Here we show that the conformation space network describes the free energy landscape without requiring projections into arbitrarily chosen reaction coordinates. The network analysis provides a basis for understanding the heterogeneity of the folding transition state and the existence of multiple pathways. [1] P. Ferrara and A. Caflisch, Folding simulations of a three-stranded antiparallel beta-sheet peptide, PNAS 97, 10780-10785 (2000). [2] Ravasz, E. and Barabási, A. L. Hierarchical organization in complex networks. Phys. Rev. E 67, 026112 (2003). [3] Dill, K. and Chan, H From Levinthal to pathways to funnels. Nature Struct. Biol. 4, 10-19 (1997)

  13. Folded waveguide coupler

    DOEpatents

    Owens, Thomas L.

    1988-03-01

    A resonant cavity waveguide coupler for ICRH of a magnetically confined plasma. The coupler consists of a series of inter-leaved metallic vanes disposed withn an enclosure analogous to a very wide, simple rectangular waveguide that has been "folded" several times. At the mouth of the coupler, a polarizing plate is provided which has coupling apertures aligned with selected folds of the waveguide through which rf waves are launched with magnetic fields of the waves aligned in parallel with the magnetic fields confining the plasma being heated to provide coupling to the fast magnetosonic wave within the plasma in the frequency usage of from about 50-200 mHz. A shorting plate terminates the back of the cavity at a distance approximately equal to one-half the guide wavelength from the mouth of the coupler to ensure that the electric field of the waves launched through the polarizing plate apertures are small while the magnetic field is near a maximum. Power is fed into the coupler folded cavity by means of an input coaxial line feed arrangement at a point which provides an impedance match between the cavity and the coaxial input line.

  14. Ab initio RNA folding

    NASA Astrophysics Data System (ADS)

    Cragnolini, Tristan; Derreumaux, Philippe; Pasquali, Samuela

    2015-06-01

    RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, the experimental determination of RNA structures through x-ray crystallography and NMR seems to have reached a plateau in the number of structures resolved each year, but as more and more RNA sequences are being discovered, the need for structure prediction tools to complement experimental data is strong. Theoretical approaches to RNA folding have been developed since the late nineties, when the first algorithms for secondary structure prediction appeared. Over the last 10 years a number of prediction methods for 3D structures have been developed, first based on bioinformatics and data-mining, and more recently based on a coarse-grained physical representation of the systems. In this review we are going to present the challenges of RNA structure prediction and the main ideas behind bioinformatic approaches and physics-based approaches. We will focus on the description of the more recent physics-based phenomenological models and on how they are built to include the specificity of the interactions of RNA bases, whose role is critical in folding. Through examples from different models, we will point out the strengths of physics-based approaches, which are able not only to predict equilibrium structures, but also to investigate dynamical and thermodynamical behavior, and the open challenges to include more key interactions ruling RNA folding.

  15. Clean coal technologies---An international seminar: Seminar evaluation and identification of potential CCT markets

    SciTech Connect

    Guziel, K.A.; Poch, L.A.; Gillette, J.L.; Buehring, W.A.

    1991-07-01

    The need for environmentally responsible electricity generation is a worldwide concern. Because coal is available throughout the world at a reasonable cost, current research is focusing on technologies that use coal with minimal environmental effects. The United States government is supporting research on clean coal technologies (CCTs) to be used for new capacity additions and for retrofits to existing capacity. To promote the worldwide adoption of US CCTs, the US Department of Energy, the US Agency for International Development, and the US Trade and Development Program sponsored a two-week seminar titled Clean Coal Technologies -- An International Seminar. Nineteen participants from seven countries were invited to this seminar, which was held at Argonne National Laboratory in June 1991. During the seminar, 11 US CCT vendors made presentations on their state-of-the-art and commercially available technologies. The presentations included technical, environmental, operational, and economic characteristics of CCTs. Information on financing and evaluating CCTs also was presented, and participants visited two CCT operating sites. The closing evaluation indicated that the seminar was a worthwhile experience for all participants and that it should be repeated. The participants said CCT could play a role in their existing and future electric capacity, but they agreed that more CCT demonstration projects were needed to confirm the reliability and performance of the technologies.

  16. Seminar on information, education and communication.

    PubMed

    1977-01-01

    A major decision of the 7th Seminar on Information, Education and Communication organized in Tokyo by the Japanese Organization for International Cooperation in Family Planning (JOICFP) held in June and July 1977 was to recommend that the term "family planning" be replaced by "family welfare." The intention of this change is to reflect the current trend of combined programs which have the objective of improving the quality of life. The major theme stressed by the seminar speakers was the importance of information, education and communication in launching improved innovative approaches and strategies in support of the integrated approach. 4 topics were selected for special consideration: 1) interpersonal communciation; 2) incentives; 3) organizational approach in family planning programs; and 4) integration of family planning with maternal and child health.

  17. High-Pressure Research Applications Seminar

    NASA Astrophysics Data System (ADS)

    Manghnani, Murli H.; Akimoto, Syun-iti; Ahrens, Thomas J.; Syono, Yasuhiko; Jeanloz, Raymond; Yagi, Takehiko

    The United States-Japan seminar on “High-Pressure Research Applications in Geophysics and Geochemistry” was held in Honolulu, Hawaii, January 13-16, 1986, under the auspices of the National Science Foundation (NSF) and the Japan Society for the Promotion of Science (JSPS). The seminar, the third in a series, was cocovened by Murli H. Manghnani (University of Hawaii, Honolulu) and Syun-iti Akimoto (University of Tokyo). Coming together for this symposium were 25 researchers from Japan, 22 from the United States, and four others, from Australia, the People's Republic of China, the Netherlands, and the Federal Republic of Germany. Of the 52 papers presented, 38 were presented orally at seven scientific sessions, and the rest were displayed at a poster session.

  18. 1990 fuel cell seminar: Program and abstracts

    SciTech Connect

    Not Available

    1990-12-31

    This volume contains author prepared short resumes of the presentations at the 1990 Fuel Cell Seminar held November 25-28, 1990 in Phoenix, Arizona. Contained herein are 134 short descriptions organized into topic areas entitled An Environmental Overview, Transportation Applications, Technology Advancements for Molten Carbonate Fuel Cells, Technology Advancements for Solid Fuel Cells, Component Technologies and Systems Analysis, Stationary Power Applications, Marine and Space Applications, Technology Advancements for Acid Type Fuel Cells, and Technology Advancement for Solid Oxide Fuel Cells.

  19. High temperature electronics and instrumentation seminar proceedings

    SciTech Connect

    Veneruso, A.F.; Arnold, C.; Simpson, R.S.

    1980-05-01

    This seminar was tailored to address the needs of the borehole logging industry and to stimulate the development and application of this technology, for logging geothermal, hot oil and gas, and steam injection wells. The technical sessions covered the following topics: hybrid circuits, electronic devices, transducers, cables and connectors, materials, mechanical tools and thermal protection. Thirty-eight papers are included. Separate entries were prepared for each one. (MHR)

  20. A Seminar on Working with Families

    PubMed Central

    Talbot, Yves; Frisch, Sara R.

    1983-01-01

    Teaching family practice residents how to work with families is an important part of their training. An eight week seminar given to family practice residents during their rotation in a pediatric hospital is presented. The learning objectives and the teaching strategies are described. Informal assessment indicates the experience was a stimulus for attitudinal change and some degree of skill development among the residents despite its relatively short duration. PMID:21286591

  1. AIDS seminars for senior grades in secondary schools.

    PubMed

    Scott, F; Chambers, L W; Underwood, J; Walter, S; Pickard, L

    1990-01-01

    AIDS seminars lasting 70 minutes, consisting of an oral presentation, a videotape and time for discussion, were offered to students in grades 11, 12 and 13 in secondary schools in the Hamilton Board of Education. Specially chosen teacher and public health nurse facilitators were assigned to sessions. 19 secondary school principals and 1,898 students in 10 schools completed questionnaires about the usefulness of the seminars. Students and principals viewed the seminars. Students and principals viewed the seminar as highly valuable for obtaining new information in sessions with either public health nurse or teacher facilitators. The oral presentation was rated most valuable but students rated the videotape and the discussion components highly as well. The students strongly agreed that the seminar assisted in understanding how STDs could be prevented, and made them aware of the community groups or agencies they could go to for help. A substantially greater number of females than males indicated they wished to attend other seminars. PMID:2207953

  2. Folding of Pollen Grains

    NASA Astrophysics Data System (ADS)

    Katifori, Eleni; Alben, Silas; Cerda, Enrique; Nelson, David; Dumais, Jacques

    2008-03-01

    At dehiscence, which occurs when the anther reaches maturity and opens, pollen grains dehydrate and their volume is reduced. The pollen wall deforms to accommodate the volume loss, and the deformation pathway depends on the initial turgid pollen grain geometry and the mechanical properties of the pollen wall. We demonstrate, using both experimental and theoretical approaches, that the design of the apertures (areas on the pollen wall where the stretching and the bending modulus are reduced) is critical for controlling the folding pattern, and ensures the pollen grain viability. An excellent fit to the experiments is obtained using a discretized version of the theory of thin elastic shells.

  3. Protein photo-folding and quantum folding theory.

    PubMed

    Luo, Liaofu

    2012-06-01

    The rates of protein folding with photon absorption or emission and the cross section of photon -protein inelastic scattering are calculated from quantum folding theory by use of a field-theoretical method. All protein photo-folding processes are compared with common protein folding without the interaction of photons (non-radiative folding). It is demonstrated that there exists a common factor (thermo-averaged overlap integral of the vibration wave function, TAOI) for protein folding and protein photo-folding. Based on this finding it is predicted that (i) the stimulated photo-folding rates and the photon-protein resonance Raman scattering sections show the same temperature dependence as protein folding; (ii) the spectral line of the electronic transition is broadened to a band that includes an abundant vibration spectrum without and with conformational transitions, and the width of each vibration spectral line is largely reduced. The particular form of the folding rate-temperature relation and the abundant spectral structure imply the existence of quantum tunneling between protein conformations in folding and photo-folding that demonstrates the quantum nature of the motion of the conformational-electronic system.

  4. Folded pendulum tiltmeter

    NASA Astrophysics Data System (ADS)

    Wu, Shuchao; Fan, Shuhua; Luo, Jun; Hsu, Houtse

    2002-05-01

    The application of the folded pendulum (FP) as a tiltmeter is proposed and some features of it have been studied both theoretically and experimentally. First, FP could have a quite low resonance frequency due to its mechanical structure. The period of our prototype FP is 6.2 s and the amplification factor is about 100. Second, FP is not sensitive to the environmental temperature variation but seriously affected by the temperature gradient. The experiment with a temperature gradient modulation shows that the static equilibrium position of the FP will change by 2.5 μrad if the temperature difference between the horizontal platform and the base of the FP is 0.1 °C. With a prototype FP, we have observed obvious tilt tides, and the calibration result shows that the resolution of the FP is about 1.2 nrad.

  5. Right On: Seminars for Women in Management; Rip Off: Seminars for Women in Management

    ERIC Educational Resources Information Center

    Roberts, Imla; Stengels, Marit

    1974-01-01

    Two trainers offer radically different views on the validity of women-only seminars in the training of women for management. Ms. Stengels objects to the further segregation of women from "the party with the most power." Ms. Roberts emphasizes the development of awareness and confidence possible in a risk-free atmosphere. (AJ)

  6. Organizing a Campus Seminar on Careers in Entertainment.

    ERIC Educational Resources Information Center

    Walt Disney Productions, Anaheim, CA.

    Developed by Walt Disney Productions as part of a project granted by the Career Education Program of the Office of Education, this handbook is designed to help college and university fine arts departments in planning and carrying out an on-campus seminar on careers in entertainment. Sections include Why Hold a Seminar on Careers in Entertainment?,…

  7. A Seminar in Legal Aspects of Minority Economic Development

    ERIC Educational Resources Information Center

    Donegan, Charles Edward

    1975-01-01

    The 2-hour elective seminar described here was designed to prepare second- and third-year law students to perform the role of legal counselor to potential and existing minority businessmen in forming or expanding business enterprises. Seminar outline and notes on materials, reading, research assignments, and resource persons are included. (JT)

  8. The Women's Studies Senior Seminar 1976-77.

    ERIC Educational Resources Information Center

    Register, Cheri; And Others

    This paper describes and evaluates two courses comprising a senior seminar designed as the culmination of a women's studies curriculum. Interdisciplinary in nature and team-taught, the seminar included studies from the fields of literature, psychology, and anthropology. The theme of the Winter 1977 course was "Women, Culture, and Power." Lectures…

  9. International Trade Seminar (Austin, Texas, December 2, 1988).

    ERIC Educational Resources Information Center

    Midland Coll., TX. Business and Economic Development Center.

    Selected presentations from a 1988 seminar on international trade hosted by Midland College (MC) are included in this report. Designed to direct west Texas businesses toward diversification and to prepare them for international trade and business opportunities, the seminar featured speakers in the field of international trade, including bank…

  10. Second Seminar on Direct Teaching by Television (Scheveningen, 1968).

    ERIC Educational Resources Information Center

    Council for Cultural Cooperation, Strasbourg (France).

    A seminar on direct teaching by television, held in Rome in December of 1966, created such interest that it was decided to call a second seminar, restricted to adult education, which was held at Scheveningen, July 1-5, 1968. The subject was the assessment of needs and evaluation of results. The purpose was to compare, at a European level, the…

  11. Integrating Webinar and Blogging Technologies into Chemistry Seminar

    ERIC Educational Resources Information Center

    Hamstra, Dan; Kemsley, Jyllian N.; Murray, Desmond H.; Randall, David W.

    2011-01-01

    We report successfully integrating webinar and blogging into an undergraduate chemistry and biochemistry seminar course. Commercial collaboration software linked speaker-operated slides with two-way voice and video effectively connecting the audience and presenter from different states. Student responses to the technology and seminar content were…

  12. Fourteenth Service Water System Reliability Improvement Seminar Proceedings

    SciTech Connect

    2002-06-01

    This report contains information presented at the Fourteenth Service Water System Reliability Improvement (SWSRI) Seminar held June 24-25, 2002, in San Diego, California. The bi-annual seminar--sponsored by EPRI--provided an opportunity for participants to exchange technical information and experiences regarding the monitoring, repair, and replacement of service water system components.

  13. Gender Differences in Workplace Communication: A Seminar Outline.

    ERIC Educational Resources Information Center

    Kenton, Sherron B.

    1990-01-01

    Presents an outline for a half-day seminar on gender differences in workplace communication, which can be modified for a class lecture/workshop in a graduate management communication or an undergraduate business communication course. Appends a role-play activity for use in the seminar. (SR)

  14. The Graduate Seminar: Another Research-Process Genre.

    ERIC Educational Resources Information Center

    Weissberg, Bob

    1993-01-01

    A qualitative study is described investigating the university graduate student seminar presentation as a speech event and its status as a genre. Findings support Swales' (1990) contention that the graduate seminar is an independent genre related to the experimental research article, not merely an oral replication. (20 references) (Author/LB)

  15. SEMINAR PUBLICATION: OPERATIONAL PARAMETERS FOR HAZARDOUS WASTE COMBUSTION DEVICES

    EPA Science Inventory

    The information in the document is based on presentations at the EPA-sponsored seminar series on Operational Parameters for Hazardous Waste Combustion Devices. This series consisted of five seminars held in 1992. Hazardous waste combustion devices are regulated under the Resource...

  16. EPA/ORD VOC RECOVERY SEMINAR VIDEOTAPE - OVERVIEW

    EPA Science Inventory

    A videotape and summary report was prepared of NRMRL's VOC Recovery Seminar, 9/16-17/1998, Cincinnati, Ohio. The Seminar and Videotape describes the state-of-the-science in VOC recovery technologies to other EPA ORD labs, program offices, regions, state and local environmental ag...

  17. Understanding How First-Year Seminars Affect Persistence

    ERIC Educational Resources Information Center

    Porter, Stephen R.; Swing, Randy L.

    2006-01-01

    First-year seminars are nearly ubiquitous fixtures in American higher education, and research has documented their positive effect on student persistence. Only limited research, however, has attempted to isolate the impact of various aspects of first-year seminars on persistence, especially on a cross-institutional basis. We use a survey of almost…

  18. Teaching Controversy by Seminar: An Example in Quaternary Geomorphology.

    ERIC Educational Resources Information Center

    Harwood, Doug

    1987-01-01

    Describes how seminar work can be structured to help students develop skills of critical thinking and expression when discussing controversial issues in their chosen subject. Particular emphasis is given to methods of organizing instructional materials and appropriate roles for seminar leaders. The debate surrounding the existence of a prehistoric…

  19. Integrating Industrial Seminars within a Graduate Engineering Programme

    ERIC Educational Resources Information Center

    Ringwood, John V.

    2013-01-01

    The benefit of external, often industry-based, speakers for a seminar series associated with both undergraduate and graduate programmes is relatively unchallenged. However, the means by which such a seminar series can be encapsulated within a structured learning module, and the appropriate design of an accompanying assessment methodology, is not…

  20. Improving Higher Education in Developing Countries. EDI Seminar Series.

    ERIC Educational Resources Information Center

    Ransom, Angela; And Others

    This volume is the result of a policy seminar on Improvement and Innovation in Higher Education in Developing Countries, organized by the Economic Development Institute and the Population and Human Resources Department of the World Bank in collaboration with the Institute of Strategic and International Studies of Malaysia. The seminar was held in…

  1. Creating Case Study Presentations: A Survey of Senior Seminar Students

    ERIC Educational Resources Information Center

    Field, Patrick

    2005-01-01

    The Senior Seminar in Biology course at Kean University teaches students who have taken core biology courses and achieved senior status to research primary literature on current topics in biology and produce a traditional seminar presentation that includes a written report and a clear and comprehensive oral talk with ensuing discussion. Senior…

  2. An Experimental Comparison of Retirement Planning Intervention Seminars.

    ERIC Educational Resources Information Center

    Hershey, Douglas A.; Mowen, John C.; Jacobs-Lawson, Joy M.

    2003-01-01

    After 1 year, the efficacy of three retirement seminars (financial planning information, n=30; financial goal-setting, n=25; combined information and goal-setting, n=25) was measured. Compared to those of 26 controls, goal clarity, planning, and savings practices of seminar participants were most changed. Strongest impact was on those in combined…

  3. A Course in Heterogeneous Catalysis Involving Video-Based Seminars.

    ERIC Educational Resources Information Center

    White, Mark G.

    1984-01-01

    A video-based format was used during a graduate seminar course designed to educate students on the nature of catalysis, to help transfer information among students working on similar problems, and to improve communication skills. The mechanics of and student reaction to this seminar course are discussed. (JN)

  4. Fuel Cell Seminar, 1992: Program and abstracts

    SciTech Connect

    Not Available

    1992-12-31

    This year`s theme, ``Fuel Cells: Realizing the Potential,`` focuses on progress being made toward commercial manufacture and use of fuel cell products. Fuel cell power plants are competing for market share in some applications and demonstrations of market entry power plants are proceeding for additional applications. Development activity on fuel cells for transportation is also increasing; fuel cell products have potential in energy and transportation industries, with very favorable environmental impacts. This Seminar has the purpose of fostering communication by providing a forum for the international community interested in development, application, and business opportunities related fuel cells. Over 190 technical papers are included, the majority being processed for the data base.

  5. Fuel Cell Seminar, 1992: Program and abstracts

    NASA Astrophysics Data System (ADS)

    1992-03-01

    This year's theme, 'Fuel Cells: Realizing the Potential,' focuses on progress being made toward commercial manufacture and use of fuel cell products. Fuel cell power plants are competing for market share in some applications and demonstrations of market entry power plants are proceeding for additional applications. Development activity on fuel cells for transportation is also increasing; fuel cell products have potential in energy and transportation industries, with very favorable environmental impacts. This Seminar has the purpose of fostering communication by providing a forum for the international community interested in development, application, and business opportunities related fuel cells. Over 190 technical papers are included, the majority being processed for the data base.

  6. How the genome folds

    NASA Astrophysics Data System (ADS)

    Lieberman Aiden, Erez

    2012-02-01

    I describe Hi-C, a novel technology for probing the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. Working with collaborators at the Broad Institute and UMass Medical School, we used Hi-C to construct spatial proximity maps of the human genome at a resolution of 1Mb. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and closed chromatin to form two genome-wide compartments. At the megabase scale, the chromatin conformation is consistent with a fractal globule, a knot-free conformation that enables maximally dense packing while preserving the ability to easily fold and unfold any genomic locus. The fractal globule is distinct from the more commonly used globular equilibrium model. Our results demonstrate the power of Hi-C to map the dynamic conformations of whole genomes.

  7. Protein folding in the ER.

    SciTech Connect

    Stevens, F. J.; Argon, Y.; Biosciences Division; Univ. of Chicago

    1999-10-01

    The endoplasmic reticulum (ER) is a major protein folding compartment for secreted, plasma membrane and organelle proteins. Each of these newly-synthesized polypeptides folds in a deterministic process, affected by the unique conditions that exist in the ER. An understanding of protein folding in the ER is a fundamental biomolecular challenge at two levels. The first level addresses how the amino acid sequence programs that polypeptide to efficiently arrive at a particular fold out of a multitude of alternatives, and how different sequences obtain similar folds. At the second level are the issues introduced by folding not in the cytosol, but in the ER, including the risk of aggregation in a molecularly crowded environment, accommodation of post-translational modifications and the compatibility with subsequent intracellular trafficking. This review discusses both the physicochemical and cell biological constraints of folding, which are the challenges that the ER molecular chaperones help overcome.

  8. Manpower Problems in the Service Sector. Background Report for a Trade Union Seminar. International Seminars 1966-2.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    The papers and discussion at an international seminar of manpower and labor experts are summarized by G. Bowen Thomas. An interpretative essay, "Manpower Problems of An Expanding Sector," by Solomon Barkin, is also included. The seminar was designed to fill the information gap and to stimulate investigations concerning common manpower and labor…

  9. Wind Turbine Tribology Seminar - A Recap

    SciTech Connect

    Errichello, R.; Sheng, S.; Keller, J.; Greco, A.

    2012-02-01

    Tribology is the science and engineering of interacting surfaces in relative motion. It includes the study and application of the principles of friction, lubrication, and wear. It is an important phenomenon that not only impacts the design and operation of wind turbine gearboxes, but also their subsequent maintenance requirements and overall reliability. With the major growth and increasing dependency on renewable energy, mechanical reliability is an extremely important issue. The Wind Turbine Tribology Seminar was convened to explore the state-of-the-art in wind turbine tribology and lubricant technologies, raise industry awareness of a very complex topic, present the science behind each technology, and identify possible R&D areas. To understand the background of work that had already been accomplished, and to consolidate some level of collective understanding of tribology by acknowledged experts, the National Renewable Energy Laboratory (NREL), Argonne National Laboratory (ANL), and the U.S. Department of Energy (DOE) hosted a wind turbine tribology seminar. It was held at the Renaissance Boulder Flatiron Hotel in Broomfield, Colorado on November 15-17, 2011. This report is a summary of the content and conclusions. The presentations given at the meeting can be downloaded. Interested readers who were not at the meeting may wish to consult the detailed publications listed in the bibliography section, obtain the cited articles in the public domain, or contact the authors directly.

  10. Evolutionary optimization of protein folding.

    PubMed

    Debès, Cédric; Wang, Minglei; Caetano-Anollés, Gustavo; Gräter, Frauke

    2013-01-01

    Nature has shaped the make up of proteins since their appearance, [Formula: see text]3.8 billion years ago. However, the fundamental drivers of structural change responsible for the extraordinary diversity of proteins have yet to be elucidated. Here we explore if protein evolution affects folding speed. We estimated folding times for the present-day catalog of protein domains directly from their size-modified contact order. These values were mapped onto an evolutionary timeline of domain appearance derived from a phylogenomic analysis of protein domains in 989 fully-sequenced genomes. Our results show a clear overall increase of folding speed during evolution, with known ultra-fast downhill folders appearing rather late in the timeline. Remarkably, folding optimization depends on secondary structure. While alpha-folds showed a tendency to fold faster throughout evolution, beta-folds exhibited a trend of folding time increase during the last [Formula: see text]1.5 billion years that began during the "big bang" of domain combinations. As a consequence, these domain structures are on average slow folders today. Our results suggest that fast and efficient folding of domains shaped the universe of protein structure. This finding supports the hypothesis that optimization of the kinetic and thermodynamic accessibility of the native fold reduces protein aggregation propensities that hamper cellular functions. PMID:23341762

  11. Early Events in RNA Folding

    NASA Astrophysics Data System (ADS)

    Thirumalai, D.; Lee, Namkyung; Woodson, Sarah A.; Klimov, Dk

    2001-10-01

    We describe a conceptual framework for understanding the way large RNA molecules fold based on the notion that their free-energy landscape is rugged. A key prediction of our theory is that RNA folding can be described by the kinetic partitioning mechanism (KPM). According to KPM a small fraction of molecules folds rapidly to the native state whereas the remaining fraction is kinetically trapped in a low free-energy non-native state. This model provides a unified description of the way RNA and proteins fold. Single-molecule experiments on Tetrahymena ribozyme, which directly validate our theory, are analyzed using KPM. We also describe the earliest events that occur on microsecond time scales in RNA folding. These must involve collapse of RNA molecules that are mediated by counterion-condensation. Estimates of time scales for the initial events in RNA folding are provided for the Tetrahymena ribozyme.

  12. Kinetic Intermediates in RNA Folding

    NASA Astrophysics Data System (ADS)

    Zarrinkar, Patrick P.; Williamson, James R.

    1994-08-01

    The folding pathways of large, highly structured RNA molecules are largely unexplored. Insight into both the kinetics of folding and the presence of intermediates was provided in a study of the Mg2+-induced folding of the Tetrahymena ribozyme by hybridization of complementary oligodeoxynucleotide probes. This RNA folds via a complex mechanism involving both Mg2+-dependent and Mg2+-independent steps. A hierarchical model for the folding pathway is proposed in which formation of one helical domain (P4-P6) precedes that of a second helical domain (P3-P7). The overall rate-limiting step is formation of P3-P7, and takes place with an observed rate constant of 0.72 ± 0.14 minute-1. The folding mechanism of large RNAs appears similar to that of many multidomain proteins in that formation of independently stable substructures precedes their association into the final conformation.

  13. Graphene folding on flat substrates

    SciTech Connect

    Chen, Xiaoming; Zhao, Yadong; Ke, Changhong; Zhang, Liuyang; Wang, Xianqiao

    2014-10-28

    We present a combined experimental-theoretical study of graphene folding on flat substrates. The structure and deformation of the folded graphene sheet are experimentally characterized by atomic force microscopy. The local graphene folding behaviors are interpreted based on nonlinear continuum mechanics modeling and molecular dynamics simulations. Our study on self-folding of a trilayer graphene sheet reports a bending stiffness of about 6.57 eV, which is about four times the reported values for monolayer graphene. Our results reveal that an intriguing free sliding phenomenon occurs at the interlayer van der Waals interfaces during the graphene folding process. This work demonstrates that it is a plausible venue to quantify the bending stiffness of graphene based on its self-folding conformation on flat substrates. The findings reported in this work are useful to a better understanding of the mechanical properties of graphene and in the pursuit of its applications.

  14. Physical experiments of transpressional folding

    NASA Astrophysics Data System (ADS)

    Tikoff, Basil; Peterson, Karl

    1998-06-01

    In order to understand the process of folding in obliquely convergent settings, we formed folds within a shear box capable of creating homogeneous transpressional deformations. Folds were created in a single layer of stiff mixed plasticine and silicone that overlay a Newtonian silicone, for a variety of plate convergence angles. As small amplitude folds became visible, they were parallel to the long axis of the horizontal finite strain ellipse. With increasing deformation, the fold hinges rotated parallel with the long axis of the horizontal finite strain ellipse for all angles of convergence. This parallelism indicates that fold hinges, once formed, rotate with the horizontal strain ellipse rather than as material lines. The experiments highlight several interesting effects of transpression dynamics. The fold hinges initiate parallel to either ṡ1 or ṡ2 and are parallel to either S1 or S2 with increasing deformation. Neither infinitesimal strain (stress) nor finite strain is resolvable solely from fold geometry. Further, the net amount of contraction determined by folding across the zone was overestimated in all cases except pure contraction. This effect is obvious for the case of wrenching, where folding implies that the zone contracts if elongation parallel to the fold hinge is not considered. Therefore, attempts to balance cross-sections in transpressional zones will tend to overestimate contraction unless the wrench component of deformation is addressed. This result is validated by applying the modeling results in folding in central California adjacent to the San Andreas fault, where cross-section balancing indicates higher amounts of contraction than predicted by plate motion.

  15. COS NUV MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2010-09-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {11891} during Cycle 17.

  16. COS NUV MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2012-10-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {12723} during Cycle 19.

  17. Compact intermediates in RNA folding

    SciTech Connect

    Woodson, S.A.

    2011-12-14

    Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transition, which coincides with the assembly of helical domains, depends on RNA sequence and counterions. It determines the specificity of the folding pathways and the magnitude of the free energy barriers to the ensuing search for the native conformation. By coupling helix assembly with nascent tertiary interactions, compact folding intermediates in RNA also play a crucial role in ligand binding and RNA-protein recognition.

  18. Folding superfunnel to describe cooperative folding of interacting proteins.

    PubMed

    Smeller, László

    2016-07-01

    This paper proposes a generalization of the well-known folding funnel concept of proteins. In the funnel model the polypeptide chain is treated as an individual object not interacting with other proteins. Since biological systems are considerably crowded, protein-protein interaction is a fundamental feature during the life cycle of proteins. The folding superfunnel proposed here describes the folding process of interacting proteins in various situations. The first example discussed is the folding of the freshly synthesized protein with the aid of chaperones. Another important aspect of protein-protein interactions is the folding of the recently characterized intrinsically disordered proteins, where binding to target proteins plays a crucial role in the completion of the folding process. The third scenario where the folding superfunnel is used is the formation of aggregates from destabilized proteins, which is an important factor in case of several conformational diseases. The folding superfunnel constructed here with the minimal assumption about the interaction potential explains all three cases mentioned above. Proteins 2016; 84:1009-1016. © 2016 Wiley Periodicals, Inc.

  19. XXII International Baldin Seminar on High Energy Physics Problems

    NASA Astrophysics Data System (ADS)

    The XXII International Baldin Seminar on High Energy Physics Problems "Relativistic Nuclear Physics and Quantum Chromodynamics", organized by the Joint Institute for Nuclear Research was held from September 15 to 20, 2014 in Dubna, Russia. The Seminar continues the series of traditional meetings and was established by an outstanding scientist Academician A.M. Baldin(1926-2001). Among conferences that were organized by Alexander Mikhailovich Baldin of special importance is just this series of the International Seminars on High-Energy Physics Problems started in 1969 with support of M.A. Markov (1908-1994). They have been given an inofficial, somewhat witty, name "Baldin autumn".

  20. The role of a research seminar for child psychiatry residents.

    PubMed

    Paniagua, F A; Pumariega, A J; O'Boyle, M; Meyer, W J

    1993-03-01

    A major problem confronting the field of child and adolescent psychiatry is the development of teaching strategies to stimulate research activities and an appreciation of research. A teaching approach is described which emphasizes major research concepts using a programmed instruction method and illustrating these concepts with clinical cases. Fourteen child psychiatry residents participated in the seminar during a 3-year period. Overall, trainees' evaluation of the seminar was positive, and they demonstrated a high level of understanding across major research topics. In addition, the seminar may have contributed to an increased preference for academic careers by graduating residents.

  1. Pseudoknots in RNA folding landscapes

    PubMed Central

    Kucharík, Marcel; Hofacker, Ivo L.; Stadler, Peter F.; Qin, Jing

    2016-01-01

    Motivation: The function of an RNA molecule is not only linked to its native structure, which is usually taken to be the ground state of its folding landscape, but also in many cases crucially depends on the details of the folding pathways such as stable folding intermediates or the timing of the folding process itself. To model and understand these processes, it is necessary to go beyond ground state structures. The study of rugged RNA folding landscapes holds the key to answer these questions. Efficient coarse-graining methods are required to reduce the intractably vast energy landscapes into condensed representations such as barrier trees or basin hopping graphs (BHG) that convey an approximate but comprehensive picture of the folding kinetics. So far, exact and heuristic coarse-graining methods have been mostly restricted to the pseudoknot-free secondary structures. Pseudoknots, which are common motifs and have been repeatedly hypothesized to play an important role in guiding folding trajectories, were usually excluded. Results: We generalize the BHG framework to include pseudoknotted RNA structures and systematically study the differences in predicted folding behavior depending on whether pseudoknotted structures are allowed to occur as folding intermediates or not. We observe that RNAs with pseudoknotted ground state structures tend to have more pseudoknotted folding intermediates than RNAs with pseudoknot-free ground state structures. The occurrence and influence of pseudoknotted intermediates on the folding pathway, however, appear to depend very strongly on the individual RNAs so that no general rule can be inferred. Availability and implementation: The algorithms described here are implemented in C++ as standalone programs. Its source code and Supplemental material can be freely downloaded from http://www.tbi.univie.ac.at/bhg.html. Contact: qin@bioinf.uni-leipzig.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID

  2. Structural Bridges through Fold Space

    PubMed Central

    Edwards, Hannah; Deane, Charlotte M.

    2015-01-01

    Several protein structure classification schemes exist that partition the protein universe into structural units called folds. Yet these schemes do not discuss how these units sit relative to each other in a global structure space. In this paper we construct networks that describe such global relationships between folds in the form of structural bridges. We generate these networks using four different structural alignment methods across multiple score thresholds. The networks constructed using the different methods remain a similar distance apart regardless of the probability threshold defining a structural bridge. This suggests that at least some structural bridges are method specific and that any attempt to build a picture of structural space should not be reliant on a single structural superposition method. Despite these differences all representations agree on an organisation of fold space into five principal community structures: all-α, all-β sandwiches, all-β barrels, α/β and α + β. We project estimated fold ages onto the networks and find that not only are the pairings of unconnected folds associated with higher age differences than bridged folds, but this difference increases with the number of networks displaying an edge. We also examine different centrality measures for folds within the networks and how these relate to fold age. While these measures interpret the central core of fold space in varied ways they all identify the disposition of ancestral folds to fall within this core and that of the more recently evolved structures to provide the peripheral landscape. These findings suggest that evolutionary information is encoded along these structural bridges. Finally, we identify four highly central pivotal folds representing dominant topological features which act as key attractors within our landscapes. PMID:26372166

  3. Structural Bridges through Fold Space.

    PubMed

    Edwards, Hannah; Deane, Charlotte M

    2015-09-01

    Several protein structure classification schemes exist that partition the protein universe into structural units called folds. Yet these schemes do not discuss how these units sit relative to each other in a global structure space. In this paper we construct networks that describe such global relationships between folds in the form of structural bridges. We generate these networks using four different structural alignment methods across multiple score thresholds. The networks constructed using the different methods remain a similar distance apart regardless of the probability threshold defining a structural bridge. This suggests that at least some structural bridges are method specific and that any attempt to build a picture of structural space should not be reliant on a single structural superposition method. Despite these differences all representations agree on an organisation of fold space into five principal community structures: all-α, all-β sandwiches, all-β barrels, α/β and α + β. We project estimated fold ages onto the networks and find that not only are the pairings of unconnected folds associated with higher age differences than bridged folds, but this difference increases with the number of networks displaying an edge. We also examine different centrality measures for folds within the networks and how these relate to fold age. While these measures interpret the central core of fold space in varied ways they all identify the disposition of ancestral folds to fall within this core and that of the more recently evolved structures to provide the peripheral landscape. These findings suggest that evolutionary information is encoded along these structural bridges. Finally, we identify four highly central pivotal folds representing dominant topological features which act as key attractors within our landscapes.

  4. Management seminar miniseries for training pharmacy residents.

    PubMed

    Gallina, J N; Jeffrey, L P; Temkin, L A; Cardi, V

    1985-02-01

    A management seminar miniseries for training hospital pharmacy residents is described. A series of lectures and workshops on the administrative aspects of hospital pharmacy practice are an integral part of a 2400-hour residency training program. Hospital pharmacy practice, clinical pharmacy practice, communication skills, and pharmacy administration and personnel management are the four major areas covered by the program. The section on pharmacy administration and personnel management is initiated in the middle of program after the residents have gained an appreciation of the intricacies of the department. The management workshops emphasize role playing and actual case-study analyses. The program's faculty members are members of the professional staff who have received formal training in the topics they teach. Twenty-two of this program's 53 graduates have assumed management positions. The management miniseries described can provide residents with the managerial skills they need to become effective pharmacy leaders.

  5. Seminar on building codes and standards

    SciTech Connect

    Not Available

    1980-01-01

    A seminar was conducted for state building code officials and state energy officials to discuss the following: status of the states regulatory activities for energy conservation standards for buildings; the development, administration, and enforcement processes for energy conservation standards affecting new construction; lighting and thermal standards for existing buildings; status of the development and implementation of the Title III Program, Building Energy Performance Standards (BEPS); and current status of the State Energy Conservation Program. The welcoming address was given by John Wenning and the keynote address was delivered by John Millhone. Four papers presented were: Building Energy Performance Standards Development, James Binkley; Lighting Standards in Existing Buildings, Dorothy Cronheim; Implementation of BEPS, Archie Twitchell; Sanctions for Building Energy Performance Standards, Sue Sicherman.

  6. Novel sequences propel familiar folds.

    PubMed

    Jawad, Zahra; Paoli, Massimo

    2002-04-01

    Recent structure determinations have made new additions to a set of strikingly different sequences that give rise to the same topology. Proteins with a beta propeller fold are characterized by extreme sequence diversity despite the similarity in their three-dimensional structures. Several fold predictions, based in part on sequence repeats thought to match modular beta sheets, have been proved correct.

  7. Problem Solving through Paper Folding

    ERIC Educational Resources Information Center

    Wares, Arsalan

    2014-01-01

    The purpose of this article is to describe a couple of challenging mathematical problems that involve paper folding. These problem-solving tasks can be used to foster geometric and algebraic thinking among students. The context of paper folding makes some of the abstract mathematical ideas involved relatively concrete. When implemented…

  8. COS NUV MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2013-10-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as Cycle 20 proposal 13128.

  9. Periodic folding of viscous sheets

    NASA Astrophysics Data System (ADS)

    Ribe, Neil M.

    2003-09-01

    The periodic folding of a sheet of viscous fluid falling upon a rigid surface is a common fluid mechanical instability that occurs in contexts ranging from food processing to geophysics. Asymptotic thin-layer equations for the combined stretching-bending deformation of a two-dimensional sheet are solved numerically to determine the folding frequency as a function of the sheet’s initial thickness, the pouring speed, the height of fall, and the fluid properties. As the buoyancy increases, the system bifurcates from “forced” folding driven kinematically by fluid extrusion to “free” folding in which viscous resistance to bending is balanced by buoyancy. The systematics of the numerically predicted folding frequency are in good agreement with laboratory experiments.

  10. Multidimensional theory of protein folding

    NASA Astrophysics Data System (ADS)

    Itoh, Kazuhito; Sasai, Masaki

    2009-04-01

    Theory of multidimensional representation of free energy surface of protein folding is developed by adopting structural order parameters of multiple regions in protein as multiple coordinates. Various scenarios of folding are classified in terms of cooperativity within individual regions and interactions among multiple regions and thus obtained classification is used to analyze the folding process of several example proteins. Ribosomal protein S6, src-SH3 domain, CheY, barnase, and BBL domain are analyzed with the two-dimensional representation by using a structure-based Hamiltonian model. The extension to the higher dimensional representation leads to the finer description of the folding process. Barnase, NtrC, and an ankyrin repeat protein are examined with the three-dimensional representation. The multidimensional representation allows us to directly address questions on folding pathways, intermediates, and transition states.

  11. Report on the Second APCA Government Affairs Seminar

    ERIC Educational Resources Information Center

    Beery, Williamina T.

    1974-01-01

    Condensed versions of prepared statements submitted by participants in a seminar on air pollution control are presented. Topics are organized under the areas of transportation, heat and power, role of the courts, and future federal legislative needs. (DT)

  12. East view of laboratory directly west of seminar room on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    East view of laboratory directly west of seminar room on south side of basement (first floor) - University of Wyoming Campus, Library, East of Ninth Street & North of Ivinson Avenue, Laramie, Albany County, WY

  13. Interior of seminar room on central south side of basement ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior of seminar room on central south side of basement (first floor), with laboratory spacew beyone, southeast view - University of Wyoming Campus, Library, East of Ninth Street & North of Ivinson Avenue, Laramie, Albany County, WY

  14. Interior of seminar room on central south side of basement ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior of seminar room on central south side of basement (first floor), north view towards north entrance to building - University of Wyoming Campus, Library, East of Ninth Street & North of Ivinson Avenue, Laramie, Albany County, WY

  15. Biology Resource Seminar: First Aid for the First Year.

    ERIC Educational Resources Information Center

    Minchella, Dennis J.; Yazvac, Cher W.; Fodrea, Rex A.; Ball, Greg

    2002-01-01

    Describes a freshman seminar course designed to help students develop academic and intellectual survival skills and adjust to university life and increase academic success as well as increase retention rates. (YDS)

  16. An Interdisciplinary Seminar on Legal Issues in Medicine.

    ERIC Educational Resources Information Center

    Moore, Dale L.

    1989-01-01

    A seminar on legal issues in medicine brings together medical (obstetrics/gynecology) and law students to promote mutual understanding of the legal and medical realms, their effects on each other, and the potential for cooperation. (MSE)

  17. Virtual seminars for disseminating medical nutrition education curriculum ideas.

    PubMed

    Kolasa, K; Poehlman, G; Jobe, A

    2000-06-01

    There is a need and a desire for educators working toward implementation of nutrition in medical schools and residency programs to share ideas and materials. The World Wide Web enables computer-mediated communications through which a medical nutrition curriculum could be discussed; however, existing formats lack focus and structure. In January 1999, a virtual seminar that focused on nutrition education in medical schools and residency programs was conducted. The seminar, titled "Making Room for Nutrition Education, was sponsored by organizations that have active medical nutrition educators. The seminar included 5 topics discussed over a 4-d period. The transcript was made available at http://www.preventivenutrition. com. There were 119 registered participants. Responses to a postseminar questionnaire were positive; there was interest in an ongoing series of virtual seminars.

  18. A Balint seminar in the family practice residency setting.

    PubMed

    Scheingold, L

    1980-02-01

    British psychoanalyst Michael Balint made important theoretical and pragmatic contributions to family practice, through the seminars of general practitioners he led at the Tavistock Clinic. A weekly Balint seminar, modeled on the Tavistock groups, was held in a family practice residency. The group of second and third year residents, co-led by a behavioral scientist and a family practice faculty member, met for 12 weeks and then re-evaluated topics and discussion format. Issues covered included physician-patient relationships, ethical dilemmas, group therapy concerns, and coping with clinic pressures. Objective evaluation of these seminars, where the goal is attitudinal rather than behavioral change, presents some difficulty. The conclusion is that residents benefited from the seminar, and that some aspects of psychoanalytic theory and technique are applicable to the teaching of behavioral science in family practice residencies.

  19. Margaret Mead's Evaluation of the First Salzburg Seminar.

    ERIC Educational Resources Information Center

    Russon, Craig; Ryback, Timothy

    2003-01-01

    Discusses the evaluation by Margaret Mead of the first Salzburg Seminar, an educational initiative undertaken to increase global understanding by broadening the perspectives of future leaders. Also describes Mead's evaluation methods. (SLD)

  20. High School and Community College Astronomy Research Seminar

    NASA Astrophysics Data System (ADS)

    Genet, Russell M.; Boyce, Pat; Buchheim, Robert; Collins, Dwight; Freed, Rachel; Harshaw, Richard; Johnson, Jolyon; Kenney, John; Wallen, Vera

    2016-06-01

    For the past decade, Cuesta College has held an Astronomy Research Seminar. Teams of high school and community college students, with guidance from instructors and advanced amateur astronomers, have made astronomical observations, reduced their data, and submitted their research results to appropriate journals. A variety of projects, using modest-aperture telescopes equipped with low-cost instruments, are within reach of motivated students. These include double star astrometry, variable star photometry, and exoplanet transit timing. Advanced scientific knowledge and mastery of sophisticated experimental skills are not required when the students are immersed within a supportive community of practice. The seminar features self-paced, online learning units, an online textbook (the Small Telescope Astronomical Research Handbook), and a supportive website sponsored by the Institute for Student Astronomical Research (www.In4StAR.org). There are no prerequisites for the seminar. This encourages everyone—including underrepresented minorities and persons with disabilities—to participate. Each participant contributes as their time, talents, and experience dictates, thus replicating the modern, professional research team. Our spring 2015 seminar was the largest yet. Volunteer assistant instructors provided local in-person leadership, while the entire seminar met online for PowerPoint presentations on proposed projects and final research results. Some 37 students from eight schools finished the seminar as coauthors of 19 papers published in the January 2016 volume of the Journal of Double Star Observations. Robotic telescopes devoted to student research are coming online at both Concordia University and the Boyce Astronomical Robotic Observatory, as is a central online sever that will provide students with uniform, cost-free reduction and analysis software. The seminar has motivated many of its graduates to pursue careers in science, engineering, and medicine, often with

  1. Fast events in protein folding

    SciTech Connect

    Woodruff, W.; Callender, R.; Causgrove, T.; Dyer, R.; Williams, S.

    1996-04-01

    The primary objective of this work was to develop a molecular understanding of how proteins achieve their native three-dimensional (folded) structures. This requires the identification and characterization of intermediates in the protein folding process on all relevant timescales, from picoseconds to seconds. The short timescale events in protein folding have been entirely unknown. Prior to this work, state-of-the-art experimental approaches were limited to milliseconds or longer, when much of the folding process is already over. The gap between theory and experiment is enormous: current theoretical and computational methods cannot realistically model folding processes with lifetimes longer than one nanosecond. This unique approach to employ laser pump-probe techniques that combine novel methods of laser flash photolysis with time-resolved vibrational spectroscopic probes of protein transients. In this scheme, a short (picosecond to nanosecond) laser photolysis pulse was used to produce an instantaneous pH or temperature jump, thereby initiating a protein folding or unfolding reaction. Structure-specific, time-resolved vibrational probes were then used to identify and characterize protein folding intermediates.

  2. The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success: Volume Five: Assessing the First-Year Seminar

    ERIC Educational Resources Information Center

    Friedman, Daniel B.

    2012-01-01

    "The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success," a five-volume series, is designed to assist educators who are interested in launching a first-year seminar or revamping an existing program. Each volume examines a different aspect of first-year seminar design or…

  3. The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success: Volume Three: Teaching in the First-Year Seminar

    ERIC Educational Resources Information Center

    Garner, Brad

    2012-01-01

    "The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success," a five-volume series, is designed to assist educators who are interested in launching a first-year seminar or revamping an existing program. Each volume examines a different aspect of first-year seminar design or…

  4. Fog spontaneously folds mosquito wings

    NASA Astrophysics Data System (ADS)

    Dickerson, Andrew K.; Liu, Xing; Zhu, Ting; Hu, David L.

    2015-02-01

    The flexibility of insect wings confers aerodynamic benefits, but can also present a hazard if exposed to fog or dew. Fog can cause water to accumulate on wings, bending them into tight taco shapes and rendering them useless for flight. In this combined experimental and theoretical study, we use high-speed video to film the spontaneous folding of isolated mosquito wings due to the evaporation of a water drop. We predict shapes of the deformed wing using two-dimensional elastica theory, considering both surface tension and Laplace pressure. We also recommend fold-resistant geometries for the wings of flapping micro-aerial vehicles. Our work reveals the mechanism of insect wing folding and provides a framework for further study of capillarity-driven folding in both natural and biomimetic systems at small scales.

  5. Protein folding by motion planning

    NASA Astrophysics Data System (ADS)

    Thomas, Shawna; Song, Guang; Amato, Nancy M.

    2005-12-01

    We investigate a novel approach for studying protein folding that has evolved from robotics motion planning techniques called probabilistic roadmap methods (PRMs). Our focus is to study issues related to the folding process, such as the formation of secondary and tertiary structures, assuming we know the native fold. A feature of our PRM-based framework is that the large sets of folding pathways in the roadmaps it produces, in just a few hours on a desktop PC, provide global information about the protein's energy landscape. This is an advantage over other simulation methods such as molecular dynamics or Monte Carlo methods which require more computation and produce only a single trajectory in each run. In our initial studies, we obtained encouraging results for several small proteins. In this paper, we investigate more sophisticated techniques for analyzing the folding pathways in our roadmaps. In addition to more formally revalidating our previous results, we present a case study showing that our technique captures known folding differences between the structurally similar proteins G and L. This research was supported in part by NSF CAREER Award CCR-9624315, NSF Grants ACI-9872126, EIA-9975018, EIA-0103742, EIA-9805823, ACR-0113971, CCR-0113974, EIA-9810937, EIA-0079874 and the Texas Higher Education Coordinating Board grant ATP-000512-0261-2001. ST was supported in part by an NSF Graduate Research Fellowship. GS was supported in part by an IBM PhD Fellowship.

  6. Electrochemistry of folded graphene edges.

    PubMed

    Ambrosi, Adriano; Bonanni, Alessandra; Pumera, Martin

    2011-05-01

    There is enormous interest in the investigation of electron transfer rates at the edges of graphene due to possible energy storage and sensing applications. While electrochemistry at the edges and the basal plane of graphene has been studied in the past, the new frontier is the electrochemistry of folded graphene edges. Here we describe the electrochemistry of folded graphene edges and compare it to that of open graphene edges. The materials were characterized in detail by high-resolution transmission electron microscopy, Raman spectroscopy, high-resolution X-ray photoelectron spectroscopy, electrochemical impedance spectroscopy and cyclic voltammetry. We found that the heterogeneous electron transfer rate is significantly lower on folded graphene edges compared to open edge sites for ferro/ferricyanide, and that electrochemical properties of open edges offer lower potential detection of biomarkers than the folded ones. It is apparent, therefore, that for sensing and biosensing applications the folded edges are less active than open edges, which should then be preferred for such applications. As folded edges are the product of thermal treatment of multilayer graphene, such thermal procedures should be avoided when fabricating graphene for electrochemical applications.

  7. PREFACE: Eurotherm Seminar 102: Thermal Management of Electronic Systems

    NASA Astrophysics Data System (ADS)

    Punch, J.; Walsh, E.

    2014-07-01

    About EUROTHERM The aim of the EUROTHERM Committee (www.eurothermcommittee.eu) is to promote and foster European cooperation in Thermal Sciences and Heat Transfer by gathering together scientists and engineers working in specialized areas. The Committee consists of members representing and appointed by national bodies in the EU countries. The current President of EUROTHERM is Professor Anton van Steenhoven from the University of Eindhoven (The Netherlands). The Committee organizes and coordinates European scientific events such as the EUROTHERM Seminars (about 4 per year) and the European Thermal Sciences Conference (every 4 years). About EUROTHERM Seminar 102 (www.eurothermseminar102.com) This seminar, part of the long-running series of European seminars on the thermal sciences, took place in June 2014 at the University of Limerick in Limerick, Ireland. The seminar addressed the topic of 'Thermal Management of Electronic Systems', a critical contemporary application area which represents a vibrant challenge for practitioners of the thermal sciences. We convey special thanks to the reviewers who have evaluated these papers. We also thank the scientific committee, consisting of internationally recognized experts. Their role has been to manage the evaluation of abstracts and the papers selection process as co-coordinators for specific topics. This seminar was hosted by the Stokes Institute at the University of Limerick. It could not have been organized without the efficient help of our administrators and technicians for IT support. This volume of Journal of Physics: Conference Series includes 27 articles presented at the seminar. Dr. Jeff Punch, Chair Stokes Institute, University of Limerick, Limerick, Ireland Email: jeff.punch@ul.ie Prof. Edmond Walsh, Co-Chair Associate Professor, Osney Laboratories, Department of Engineering Science, University of Oxford, UK Email: edmond.walsh@bnc.ox.ac.uk

  8. Foreland basins and fold belts

    SciTech Connect

    Macqueen, R.W.; Leckie, D.A. )

    1992-01-01

    The papers in this book describe six foreland basins and fold belts in terms of their regional setting, stratigraphy, tectonics, and structure, and their oil and gas systems. All of the basins show general similarities, but each differs significantly in detail from the others, posing something of a problem in terms of arriving at a 'typical' foreland basin and fold belt. Some are major hydrocarbon producers; others are not. The major characteristics of the six foreland basins and fold belts are summarized in Tables 1 through 5, which provide a convenient means of comparing and contrasting these basins and their hydrocarbon resources. The Western Canada foreland basin and fold belt serves as the type example for several reasons. These include: its setting and clear relationship to a major orogene of Mesozoic-Cenozoic age; the fact that it is uncomplicated by later overprinting, segmentation, or cover rocks unlike the Ouachita, Eastern Venezuela, and U.S. Rocky Mountain foreland basins and fold belts); the fact that there is a large volume of publicly available data on the basin and an active exploration and research community; and the fact that it has reasonable oil and gas reserves in a well-defined stratigraphic framework.

  9. Rapid compaction during RNA folding

    NASA Astrophysics Data System (ADS)

    Russell, Rick; Millett, Ian S.; Tate, Mark W.; Kwok, Lisa W.; Nakatani, Bradley; Gruner, Sol M.; Mochrie, Simon G. J.; Pande, Vijay; Doniach, Sebastian; Herschlag, Daniel; Pollack, Lois

    2002-04-01

    We have used small angle x-ray scattering and computer simulations with a coarse-grained model to provide a time-resolved picture of the global folding process of the Tetrahymena group I RNA over a time window of more than five orders of magnitude. A substantial phase of compaction is observed on the low millisecond timescale, and the overall compaction and global shape changes are largely complete within one second, earlier than any known tertiary contacts are formed. This finding indicates that the RNA forms a nonspecifically collapsed intermediate and then searches for its tertiary contacts within a highly restricted subset of conformational space. The collapsed intermediate early in folding of this RNA is grossly akin to molten globule intermediates in protein folding.

  10. Proceedings of the USNRC/EPRI/ANL Heated Crevice Seminar

    SciTech Connect

    2004-06-01

    An international Heated Crevice Seminar, sponsored by the Division of Engineering Technology, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission, Argonne National Laboratory, and the Electric Power Research Institute, was held at Argonne National Laboratory on October 7-11, 2002. The objective of the seminar was to provide a working forum for the exchange of information by contributing experts on current issues related to corrosion in heated crevices, particularly as it relates to the integrity of pressurized water reactor (PWR) steam generator tubes. Forty-five persons from six countries attended the seminar, including representatives from government agencies, private industry and consultants, government research laboratories, nuclear vendors, and electrical utilities. The seminar opened with keynote talks on secondary-side crevice environments associated with intergranular attack (IGA) and intergranular corrosion cracking (IGSCC) of mill-annealed Alloy 600 steam generator tubes and the submodes of corrosion in heat transfer crevices. This was followed by technical sessions on (1) Corrosion in Crevice Geometries, (2) Experimental Methods, (3) Results from Experimental Studies, and (4) Modeling. The seminar concluded with a panel discussion on the present understanding of corrosive processes in heated crevices and future research needs.

  11. Proceedings of the USNRC/EPRI/ANL heated crevice seminar.

    SciTech Connect

    Park, J. Y.; Fruzzetti, K.; Muscara, J.; Diercks, D. R.; Energy Technology; EPRI; USNRC

    2003-08-31

    An international Heated Crevice Seminar, sponsored by the Division of Engineering Technology, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission, Argonne National Laboratory, and the Electric Power Research Institute, was held at Argonne National Laboratory on October 7-11, 2002. The objective of the seminar was to provide a working forum for the exchange of information by contributing experts on current issues related to corrosion in heated crevices, particularly as it relates to the integrity of PWR steam generator tubes. Forty-five persons from six countries attended the seminar, including representatives from government agencies, private industry and consultants, government research laboratories, nuclear vendors, and electrical utilities. The seminar opened with keynote talks on secondary-side crevice environments associated with IGA and IGSCC of mill-annealed Alloy 600 steam generator tubes and the submodes of corrosion in heat transfer crevices. This was followed by technical sessions on (1) Corrosion in Crevice Geometries, (2) Experimental Methods, (3) Results from Experimental Studies, and (4) Modeling. The seminar concluded with a panel discussion on the present understanding of corrosive processes in heated crevices and future research needs.

  12. NoFold: RNA structure clustering without folding or alignment.

    PubMed

    Middleton, Sarah A; Kim, Junhyong

    2014-11-01

    Structures that recur across multiple different transcripts, called structure motifs, often perform a similar function-for example, recruiting a specific RNA-binding protein that then regulates translation, splicing, or subcellular localization. Identifying common motifs between coregulated transcripts may therefore yield significant insight into their binding partners and mechanism of regulation. However, as most methods for clustering structures are based on folding individual sequences or doing many pairwise alignments, this results in a tradeoff between speed and accuracy that can be problematic for large-scale data sets. Here we describe a novel method for comparing and characterizing RNA secondary structures that does not require folding or pairwise alignment of the input sequences. Our method uses the idea of constructing a distance function between two objects by their respective distances to a collection of empirical examples or models, which in our case consists of 1973 Rfam family covariance models. Using this as a basis for measuring structural similarity, we developed a clustering pipeline called NoFold to automatically identify and annotate structure motifs within large sequence data sets. We demonstrate that NoFold can simultaneously identify multiple structure motifs with an average sensitivity of 0.80 and precision of 0.98 and generally exceeds the performance of existing methods. We also perform a cross-validation analysis of the entire set of Rfam families, achieving an average sensitivity of 0.57. We apply NoFold to identify motifs enriched in dendritically localized transcripts and report 213 enriched motifs, including both known and novel structures.

  13. What I Did Last Summer: The Fulbright-Hays Seminars Abroad.

    ERIC Educational Resources Information Center

    Martin, Marlene

    2003-01-01

    Describes the Fulbright-Hays seminar and the author's experience with it. Discusses the application process and experiences with Fulbright seminars in Poland, Hungary, Peru, and Ecuador. Notes how she and her colleagues use Fulbright information in their classrooms. (SG)

  14. Quantum theory on protein folding

    NASA Astrophysics Data System (ADS)

    Luo, LiaoFu

    2014-03-01

    The conformational change of biological macromolecule is investigated from the point of quantum transition. A quantum theory on protein folding is proposed. Compared with other dynamical variables such as mobile electrons, chemical bonds and stretching-bending vibrations the molecular torsion has the lowest energy and can be looked as the slow variable of the system. Simultaneously, from the multi-minima property of torsion potential the local conformational states are well defined. Following the idea that the slow variables slave the fast ones and using the nonadiabaticity operator method we deduce the Hamiltonian describing conformational change. It is shown that the influence of fast variables on the macromolecule can fully be taken into account through a phase transformation of slow variable wave function. Starting from the conformation-transition Hamiltonian the nonradiative matrix element was calculated and a general formulas for protein folding rate was deduced. The analytical form of the formula was utilized to study the temperature dependence of protein folding rate and the curious non-Arrhenius temperature relation was interpreted. By using temperature dependence data the multi-torsion correlation was studied. The decoherence time of quantum torsion state is estimated. The proposed folding rate formula gives a unifying approach for the study of a large class problems of biological conformational change.

  15. Semiempirical prediction of protein folds

    NASA Astrophysics Data System (ADS)

    Fernández, Ariel; Colubri, Andrés; Appignanesi, Gustavo

    2001-08-01

    We introduce a semiempirical approach to predict ab initio expeditious pathways and native backbone geometries of proteins that fold under in vitro renaturation conditions. The algorithm is engineered to incorporate a discrete codification of local steric hindrances that constrain the movements of the peptide backbone throughout the folding process. Thus, the torsional state of the chain is assumed to be conditioned by the fact that hopping from one basin of attraction to another in the Ramachandran map (local potential energy surface) of each residue is energetically more costly than the search for a specific (Φ, Ψ) torsional state within a single basin. A combinatorial procedure is introduced to evaluate coarsely defined torsional states of the chain defined ``modulo basins'' and translate them into meaningful patterns of long range interactions. Thus, an algorithm for structure prediction is designed based on the fact that local contributions to the potential energy may be subsumed into time-evolving conformational constraints defining sets of restricted backbone geometries whereupon the patterns of nonbonded interactions are constructed. The predictive power of the algorithm is assessed by (a) computing ab initio folding pathways for mammalian ubiquitin that ultimately yield a stable structural pattern reproducing all of its native features, (b) determining the nucleating event that triggers the hydrophobic collapse of the chain, and (c) comparing coarse predictions of the stable folds of moderately large proteins (N~100) with structural information extracted from the protein data bank.

  16. Breaking the Silence in the Counselor Education Classroom: A Training Seminar on Counseling Sexual Minority Clients.

    ERIC Educational Resources Information Center

    Pearson, Quinn M.

    2003-01-01

    A counselor training seminar on sexual orientation is presented in this article. The seminar incorporated popular songs, readings, and class discussion to increase awareness of sexual identity development, stereotypes, and counseling interventions for lesbian, gay, and bisexual (LGB) clients. Results of evaluations suggest that the seminar had a…

  17. An Evaluation of a Career Development Seminar Using Crites' Career Maturity Inventory.

    ERIC Educational Resources Information Center

    Ganster, Daniel C.; Lovell, John E.

    Holland's (1973) theory served as a basis for designing a 15-hour career development seminar for 24 undergraduate students. A Solomon four-group design (Campbell and Stanley, 1963) was employed to evaluate the effectiveness of the seminar, with the Career Maturity Inventory (Crites, 1973) serving as the dependent measure. Seminar participants…

  18. 48 CFR 3452.242-73 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., conferences, and seminars to persons with disabilities. 3452.242-73 Section 3452.242-73 Federal Acquisition..., and seminars to persons with disabilities. As prescribed in 3442.7101(b), insert the following clause in all solicitations and contracts: Accessibility of Meetings, Conferences, and Seminars to...

  19. 34 CFR 664.11 - What is a short-term seminar project?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What is a short-term seminar project? 664.11 Section... Projects Does the Secretary Assist Under This Program? § 664.11 What is a short-term seminar project? A short-term seminar project is— (a) Designed to help integrate international studies into an...

  20. College First-Year Seminars: What Are We Doing, What Should We Be Doing?

    ERIC Educational Resources Information Center

    Reid, Karen M.; Reynolds, Ralph E.; Perkins-Auman, Peggy G.

    2014-01-01

    The modern concept of first-year seminars was introduced in 1972. Ninety-four percent of America's accredited 4-year colleges and universities offered a seminar by 2002. "First-year seminar" defines a fairly diverse instructional construct, but the goal remains to improve student retention rates. Research trends indicate a positive and…

  1. 34 CFR 664.11 - What is a short-term seminar project?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What is a short-term seminar project? 664.11 Section... Projects Does the Secretary Assist Under This Program? § 664.11 What is a short-term seminar project? A short-term seminar project is— (a) Designed to help integrate international studies into an...

  2. Exploring Differences in Online Professional Development Seminars with the Community of Inquiry Framework

    ERIC Educational Resources Information Center

    Fusco, Judi; Haavind, Sarah; Remold, Julie; Schank, Patricia

    2011-01-01

    Four sessions of two professional development seminars were offered to members of an organization. The seminars were voluntary, free of charge, and participants did not receive credit for their attendance. Participation rates and exit survey ratings for the four sessions varied. After the seminars, an analysis using the community of inquiry…

  3. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., conferences, and seminars to persons with disabilities. 2452.222-70 Section 2452.222-70 Federal Acquisition... seminars to persons with disabilities. As prescribed in 2422.1408(c), insert the following clause in all solicitations and contracts: Accessibility of Meetings, Conferences, and Seminars to Persons With...

  4. 48 CFR 3452.242-73 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., conferences, and seminars to persons with disabilities. 3452.242-73 Section 3452.242-73 Federal Acquisition..., and seminars to persons with disabilities. As prescribed in 3442.7101(b), insert the following clause in all solicitations and contracts: Accessibility of Meetings, Conferences, and Seminars to...

  5. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., conferences, and seminars to persons with disabilities. 2452.222-70 Section 2452.222-70 Federal Acquisition... seminars to persons with disabilities. As prescribed in 2422.1408(c), insert the following clause in all solicitations and contracts: Accessibility of Meetings, Conferences, and Seminars to Persons With...

  6. An Interdisciplinary Study of the SARS Virus: A One-Semester First-Year Seminar

    ERIC Educational Resources Information Center

    Ealy, Julie; Dorward, Adrienne

    2005-01-01

    The rationale for the first-year seminar is to introduce freshmen to the university. The basic components of a first-year seminar are academic integrity, skill development, a sense of community, active and collaborative learning strategies, and technology. All freshmen must take a first-year seminar that consists primarily of freshmen, although…

  7. 48 CFR 3452.242-73 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., conferences, and seminars to persons with disabilities. 3452.242-73 Section 3452.242-73 Federal Acquisition..., conferences, and seminars to persons with disabilities. As prescribed in 3442.7101(b), insert the following clause in all solicitations and contracts: Accessibility of Meetings, Conferences, and Seminars...

  8. Using the Nominal Group Technique to Select the Most Appropriate Topics for Postgraduate Research Students' Seminars

    ERIC Educational Resources Information Center

    Jones, Sandra C.

    2004-01-01

    In 2003, the Faculty of Health & Behavioural Sciences at our university offered a series of postgraduate research seminars. The series of seminars, selected by a three-person faculty team, received a mixed reaction--some seminars attracted a large proportion of the students whereas others were poorly attended. Thus, it was decided to continue…

  9. Proceedings of the China-Japan-U.S. Seminar on Mathematical Education.

    ERIC Educational Resources Information Center

    Zhang, Dianzhou, Ed.; And Others

    This document contains the proceedings of the China-Japan-U.S. Seminar on Mathematical Education that was held in 1993 in China. The focus of the Seminar was problem solving in mathematics education. The main purposes of the seminar were: to examine the present states of problem solving in school mathematics in China, Japan, and the U.S.; to…

  10. Regional Seminar on Review of RECSAM's Progress and Programmes for 1975 - 1980. Final Report.

    ERIC Educational Resources Information Center

    Southeast Asian Ministers of Education Organization (Singapore). Regional Center for Education in Science and Mathematics.

    This document consists primarily of papers and speeches presented at a seminar convened in Malaysia. It also includes an outline of the seminar proceedings, a list of the participants and staff members, a list of the organizing committee, and several reports of the findings and recommendations of the seminar working groups. Papers presented to the…

  11. Rondeau Seminars amalgamated mid-sagittal (lateral) cephalometric analysis.

    PubMed

    Palencar, Adrian J

    2014-01-01

    The author presents a comprehensive International Association for Orthodontics--Rondeau Seminars Amalgamated Mid-sagittal (Lateral) Cephalometric Analysis. Norms on the Cephalometric Data Sheet are age and gender specific for the Caucasian population and the postings are color coded for visual attraction. If the patient is ofa different ethnic group, the Norms should be adjusted accordingly. This Cephalometric Analysis is comprised often Sections, in alphabetical order and twenty nine Factors. The author expanded Rondeau Seminars Cephalometric Analysis by only six Factors, thus fulfilling the requirement for the case presentation for the Fellow of the IAO and the Diplomate ofthe IBO.

  12. International Summer Student Seminar (3S), from Idea to Realization

    NASA Astrophysics Data System (ADS)

    Karpik, A. P.; Peled, A.; Musikhin, L. A.; Deren, L.; Seredovich, V. A.

    2012-08-01

    The article gives a spotlight on a three universities (Moscow State University of Geodesy and Cartography, Siberian State Academy of Geodesy, Wuhan University) and ISPRS' cooperation in organizing and holding summer student seminars for undergraduate, master, and PhD students of the universities specializing in photogrammetry, remote sensing, GIS, aerial and space cartography. Principles of topics of the seminar selection, lecture courses delivering and practical training as well as international joint team work on projects and their defence are described. The description of the basic stages of 3S implementation, and the goals of this sort of the international event is given.

  13. Folded supersymmetry with a twist

    DOE PAGES

    Cohen, Timothy; Craig, Nathaniel; Lou, Hou Keong; Pinner, David

    2016-03-30

    Folded supersymmetry (f-SUSY) stabilizes the weak scale against radiative corrections from the top sector via scalar partners whose gauge quantum numbers differ from their Standard Model counterparts. This non-trivial pairing of states can be realized in extra-dimensional theories with appropriate supersymmetry-breaking boundary conditions. We present a class of calculable f-SUSY models that are parametrized by a non-trivial twist in 5D boundary conditions and can accommodate the observed Higgs mass and couplings. Although the distinctive phenomenology associated with the novel folded states should provide strong evidence for this mechanism, the most stringent constraints are currently placed by conventional supersymmetry searches. Asmore » a result, these models remain minimally fine-tuned in light of LHC8 data and provide a range of both standard and exotic signatures accessible at LHC13.« less

  14. Steric constraints as folding coadjuvant

    NASA Astrophysics Data System (ADS)

    Tarragó, M. E.; Rocha, Luiz F.; Dasilva, R. A.; Caliri, A.

    2003-03-01

    Through the analyses of the Miyazawa-Jernigan matrix it has been shown that the hydrophobic effect generates the dominant driving force for protein folding. By using both lattice and off-lattice models, it is shown that hydrophobic-type potentials are indeed efficient in inducing the chain through nativelike configurations, but they fail to provide sufficient stability so as to keep the chain in the native state. However, through comparative Monte Carlo simulations, it is shown that hydrophobic potentials and steric constraints are two basic ingredients for the folding process. Specifically, it is shown that suitable pairwise steric constraints introduce strong changes on the configurational activity, whose main consequence is a huge increase in the overall stability condition of the native state; detailed analysis of the effects of steric constraints on the heat capacity and configurational activity are provided. The present results support the view that the folding problem of globular proteins can be approached as a process in which the mechanism to reach the native conformation and the requirements for the globule stability are uncoupled.

  15. A Multidisciplinary First-Year Seminar about Tuberculosis.

    ERIC Educational Resources Information Center

    Fluck, Richard A.

    2001-01-01

    Describes a writing intensive seminar for college freshman. Includes goals, reading assignments, writing assignments, and group projects. Provides web-based resources on tuberculosis along with an evaluation sheet for web site reviews. Concludes that students exhibited great interest in the topic and course feedback was positive. (DLH)

  16. Reflections of Students in Their Use of Asynchronous Online Seminars

    ERIC Educational Resources Information Center

    Groves, Mark; O'Donoghue, John

    2009-01-01

    This paper reports on research that has been carried out into the use, process, and effectiveness of an asynchronous online seminar within an undergraduate sports studies degree programme. Contemporary sources are used to justify the use of technology supported learning (TSL) in higher education and to inform a reflective and critical account of…

  17. Medical examiners' seminar looked at mysteries surrounding sudden death

    PubMed Central

    Grant, D

    1997-01-01

    Medical examiners in Nova Scotia recently attended their first-ever seminar concerning the skills, challenges and techniques their jobs require. It was welcomed by the physicians, most of whom are family physicians with little training in the investigation of sudden death. PMID:9307567

  18. Results from the Independent Evaluation of the Seminars on Science

    ERIC Educational Resources Information Center

    Stokes, Laura; St. John, Mark; Hirabayashi, Judy; Smith, Anita

    2007-01-01

    In 1998, the American Museum of Natural History (AMNH) launched an ambitious effort to create on-line science courses for K-12 educators that would immerse them in exciting science topics and give them access to the Museum's scientific resources (scientists, research, expeditions, collections, and exhibitions). This project, called Seminars on…

  19. Summer Pre-College Seminar. Camelot. The Challenge Story.

    ERIC Educational Resources Information Center

    Hayman, Ed

    This paper discusses the 1970 Pre-College Seminar conducted by the University of Michigan Flint College for Flint high school students. A two phase program was designed to acknowledge the differing needs of the participants. The first phase was a six week program for all students without regard to their grade achievement. The second phase was…

  20. Structuring an Undergraduate Mathematics Seminar Dealing with Options and Hedging

    ERIC Educational Resources Information Center

    Prevot, K. J.

    2006-01-01

    Offering mathematics majors the opportunity to engage in current, real-world applications can be an important enhancement to their undergraduate course curriculum. Instead of focusing on the traditional topic areas in pure and/or applied mathematics, one may structure a seminar course for senior mathematics majors by concentrating on a specific…

  1. Fulbright-Hays Seminars Abroad Program: Malaysia 1995. Participants' Reports.

    ERIC Educational Resources Information Center

    Malaysian-American Commission on Educational Exchange, Kuala Lumpur.

    These reports and lesson plans were developed by teachers and coordinators who traveled to Malaysia during the summer of 1995 as part of the U.S. Department of Education's Fulbright-Hays Seminars Abroad Program. Sections of the report include: (1) "Gender and Economics: Malaysia" (Mary C. Furlong); (2) "Malaysia: An Integrated, Interdisciplinary…

  2. Planning Education for Reducing Inequalities. An IIEP Seminar.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    Based on the realization that the rapid worldwide growth of educational systems over the last two decades has not produced the expected eradication of social inequality, an international seminar was held for educational policy-makers, planners from developing countries, research workers in the area, and representatives of aid agencies of 33…

  3. Seminar in Language and Language Learning. Final Report.

    ERIC Educational Resources Information Center

    Washington Univ., Seattle.

    Collected here are ten unpublished work papers from a 1962 Seminar in Seattle, held for the purpose of evaluating the interdisciplinary needs of the doctoral candidate who is receiving special training to organize the teaching of foreign languages in schools and universities. Authors are Dwight L. Bolinger (linguistics), John B. Carroll (programed…

  4. Innovative Training and Employment of Women: Seminar Report.

    ERIC Educational Resources Information Center

    European Centre for the Development of Vocational Training, Berlin (West Germany).

    Materials and findings are provided from a seminar to improve information on the state of development in the materialization of education successful in improving women's professional status and to propose some possibilities in implementing some of these pilot projects on a wide scale. The first section summarizes reports from women who have…

  5. Ice Cream Seminars for Graduate Students: Imparting Chemical Information Literacy

    ERIC Educational Resources Information Center

    Garritano, Jeremy R.

    2007-01-01

    This article provides information on a chemical information literacy program designed primarily for new graduate students. The full implementation of this program is discussed, including defining its purpose, topics covered, content presented, methods of marketing, and evaluation. The result is a series of voluntary seminars given biweekly…

  6. Toward the Unnamed: Creative Strategies in a Fine Arts Seminar.

    ERIC Educational Resources Information Center

    Careau, Steven

    2001-01-01

    Describes an honors-level fine arts seminar that culminates in the creation of an 'unnamed' object. Stresses direct manipulation of materials leading to works free of conceptual pre-determination. Argues that naming follows creation; leaving a work unnamed allows artists to experience the dynamic of creation. (NB)

  7. Teaching Critical Thinking: Using Seminars for 21st Century Literacy

    ERIC Educational Resources Information Center

    Roberts, Terry; Billings, Laura

    2012-01-01

    Help students meet today's literacy demands with this new book from Terry Roberts and Laura Billings. The authors show how a seminar approach can lead students deeper into a text and improve their speaking, listening, and writing skills, as recommended by the Common Core State Standards. Roberts and Billings provide easy-to-follow information on…

  8. Preparing Ethical Chemists through a Second-Year Seminar Course

    ERIC Educational Resources Information Center

    Singiser, Richard H.; Clower, Caroline E.; Burnett, Stephen C.

    2012-01-01

    Ethics is an important part of science and is often omitted from a packed undergraduate curriculum. This article describes a second-year seminar course developed for chemistry majors that focuses on career preparation and the improvement of essential student skills, such as communication skills and preparation for independent research. The central…

  9. Serious Games: A Seminar Map for International Business Schools

    ERIC Educational Resources Information Center

    Witte, Anne E.

    2014-01-01

    One business school addressed the "zeitgeist" of the financial crisis by introducing in its inaugural seminar the cultural and ethical values too often absent from the types of transactions students are trained to manage. Drawing from cross-cultural and communication studies, the author tested "serious games"--cultural…

  10. Depth Psychology and Student Films: An Experimental Seminar.

    ERIC Educational Resources Information Center

    Timberg, Bernard M.

    1980-01-01

    Describes a seminar which organized a series of student films by characterizing their surface themes and patterns of symbolic expression beneath their surface layers, using Jungian psychology. Implications of student films as overt and covert vehicles of self-expression are discussed. (JMF)

  11. GCLR Web Seminars as a Venue for Transformative Educational Policy

    ERIC Educational Resources Information Center

    Angay-Crowder, Tuba; Albers, Peggy; Pace, Christi L.; Jung, Jin Kyeong Frances; Hwang, Ju A.; Pang, Myoung Eun

    2014-01-01

    This article features a discussion about the significance of global perspectives in shaping critical literacy through a web seminar project, Global Conversations in Literacy Research (GCLR). Ubiquitous media and worldwide communication via Internet change the perceptions about literacy and language, urging critical discussions around literacy…

  12. Communicating about Sexuality: An Interdisciplinary Undergraduate Honors Seminar.

    ERIC Educational Resources Information Center

    Rozema, Hazel J.

    A course in the honors program (a sophomore level social science seminar) at Millikin University offers an interdisciplinary approach to communication and sexuality, functions as a course in the Gender Studies Minor curriculum, and provides a needed source of sex education for the campus. The purpose of the course is to facilitate communication…

  13. Incorporating Business Communication in an Integrative Business Seminar.

    ERIC Educational Resources Information Center

    Luse, Donna W.

    1999-01-01

    Describes the Integrative Business Seminar in the College of Business Administration at Northeast Louisiana University in which the principal courses in business communication, management, marketing, and finance as well as a segment in problem solving, are taught as one 15-credit hour block in which subject areas are treated as an integrated…

  14. Seminar On Sanitation for Restaurant Owners and Managers. Unit I.

    ERIC Educational Resources Information Center

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, the conceptual outline is organized to provide four hours of classroom instruction. Two major concepts are emphasized. The first concept, the effect of sanitary practices on the financial profits of food service, focuses on: (1) service and quality to…

  15. Social and Emotional Learning in a Freshman Seminar

    ERIC Educational Resources Information Center

    Wyatt, Jeannette B.; Bloemker, Geraldine A.

    2013-01-01

    First year college students are challenged both socially and academically in their transition to college life. The literature suggests that social and emotional competence skills can help with this transition. This article describes the course content for a University freshman seminar that teaches skills in social and emotional competence in order…

  16. 1982 UCC-ND/GAT environmental protection seminar: proceedings

    SciTech Connect

    Not Available

    1983-04-01

    This environmental protection seminar was divided into seven sessions: (1) general environmental protection, (2) air and water pollution control, (3) spill control and countermeasures, (4) toxic materials control, (5) hazardous materials control, (6) environmental protection projects, and (7) cost benefit analysis. Separate abstracts have been prepared for the 41 papers presented therein. (ACR)

  17. Using a Senior Seminar for Assessing the Major.

    ERIC Educational Resources Information Center

    Morgan, Betsy Levonian; Johnson, Emily J.

    1997-01-01

    Describes the course content and structure of a one-credit, elective senior seminar designed to inform a college psychology department about the effectiveness of their instruction. Assessment measures included a faculty-generated multiple choice test, a student-generated multiple choice test, student surveys, focus groups, and a student essay on…

  18. Cooperative Cataloging: LC Promotes Cooperation at Asian Materials Seminar.

    ERIC Educational Resources Information Center

    Fineberg, Gail

    1998-01-01

    Discusses the Asian Materials Cataloging Seminar that the Library of Congress sponsored to promote the benefits of cooperative cataloging. Highlights include the Program for Cooperative Cataloging (PCC); high-quality, standardized, core-level cataloging records for Asian materials; name authority and subject authority programs; and the CONSER…

  19. Mexico 1996. Fulbright-Hays Summer Seminar Abroad 1996 (Mexico).

    ERIC Educational Resources Information Center

    Lopez, Salvador

    This paper shares the impressions of a participant from the 1996 Fulbright-Hays Summer Seminars Abroad Program in Mexico. These impressions address several current interest topics about international relations with Mexico including: (1) immigration; (2) politics; (3) education; (4) the economy; (5) the environment; (6) the media; (7) religion; and…

  20. Inequalities in Educational Development: Papers Presented at an IIEP Seminar.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    Based on the realization that the rapid worldwide growth of educational systems over the last two decades has not produced the expected eradication of social inequality, an international seminar was held for educational policy-makers, planners from developing countries, research workers in the area, and representatives of aid agencies from 33…

  1. A "Careers in Medicine Seminar" for Secondary School Students

    ERIC Educational Resources Information Center

    Rodgers, Glen E.; And Others

    1976-01-01

    Describes a Thanksgiving weekend seminar for high school students sponsored for the last four years by Muskingum College. Information on careers and educational requirements were presented in lectures, panel and small group discussions, and direct informal contact with practicing professionals and medical educators. (JT)

  2. Maximizing Educator Enhancement: Aligned Seminar and Online Professional Development

    ERIC Educational Resources Information Center

    Shaha, Steven; Glassett, Kelly; Copas, Aimee; Huddleston, T. Lisa

    2016-01-01

    Professional development and learning has a long history in seminar-like models, as well as in the more educator-personal delivery approaches. The question is whether an intentionally coordinated, integrated combination of the two PDL approaches will have best impacts for educators as quantified in improved student performance. Contrasts between…

  3. Three Perspectives on the 2012 ACTE National Policy Seminar

    ERIC Educational Resources Information Center

    Comer, Jim; Beasley, Candice; Moody, Kimberly; Nelson, Christine

    2012-01-01

    The ACTE National Policy Seminar (NPS) is a time for Association of Career and Technical Education (ACTE) members to meet with Members of Congress or their staff, hear from high-ranking officials in various levels of government, attend educational sessions, network with fellow ACTE members and more. In this article, the authors provide their…

  4. The Multinational Society: Papers of the Ljubljana Seminar.

    ERIC Educational Resources Information Center

    Mackey, William F., Ed.; Verdoodt, Albert, Ed.

    The Ljubljana seminar, whose background and working papers are presented in this volume, was an outcome of the United Nations' consideration of the problems of ethnic and linguistic minorities. The twenty-five papers cover topics such as the study of multinational societies; the protection of minorities and minority rights in Yugoslavia,…

  5. Hamlet on the Macintosh: An Experimental Seminar That Worked.

    ERIC Educational Resources Information Center

    Strange, William C.

    1987-01-01

    Describes experimental college Shakespeare seminar that used Macintosh computers and software called ELIZA and ADVENTURE to develop character dialogs and adventure games based on Hamlet's characters and plots. Programming languages are examined, particularly their relationship to metaphor, and the use of computers in humanities is discussed. (LRW)

  6. Group Seminars: Dialogues To Enhance Professional Development and Reflection.

    ERIC Educational Resources Information Center

    Wiltz, Nancy W.

    Group seminars, or small discussion groups, support cooperative reflection between teachers, expose interns to new perspectives, help them develop professional relationships, and allow time for them to expand and deepen their reflective analysis of everyday occurrences. A group of 15 student teachers in an early childhood program at one university…

  7. ANTA Training Update Seminar Proceedings (Brisbane, Australia, July 10, 1997).

    ERIC Educational Resources Information Center

    Australian National Training Authority, Brisbane.

    This document contains the papers and questions submitted at the Australian National Training Authority's 1997 training update seminar, which focused on vocational education and training in schools and in technical and further education (TAFE) institutions across Australia. The following papers are included: "Welcome and Comments" (Stuart…

  8. Overseas Students and Reorientation Seminars: Can They Go Home Again?

    ERIC Educational Resources Information Center

    Brislin, Richard W.; Van Buren, H.

    One of the implicit assumptions of the East-West Center is that Asian, Pacific, and United States grantees will learn about the nature of people who have a multicultural orientation. One aspect of such people is the nature of issues faced when the move from their "home" culture to another and back. The Center offers a seminar to train people to…

  9. A Longitudinal Assessment of a Managerial Grid Seminar Training Program

    ERIC Educational Resources Information Center

    Keller, Robert T.

    1978-01-01

    A Managerial Grid seminar training program was instituted for 131 participants from an oil refinery and chemical plant of a major American oil corporation. It was concluded that the Grid program itself had not caused any major variables to change. (Author)

  10. Proceedings of the Third EPRI Phased Array Ultrasound Seminar

    SciTech Connect

    2003-12-01

    Phased array technology for ultrasonic examination is providing innovative solutions for nuclear in-service examination applications. EPRI has been a prime mover in the development and deployment of phased array ultrasound applications in the domestic nuclear market over the past decade. As part of this strategic effort, EPRI has hosted a series of seminars on phased array technology and its applications.

  11. A Successful Senior Seminar: Unsolved Problems in Number Theory

    ERIC Educational Resources Information Center

    Styer, Robert

    2014-01-01

    The "Unsolved Problems in Number Theory" book by Richard Guy provides nice problems suitable for a typical math major. We give examples of problems that have worked well in our senior seminar course and some nice results that senior math majors can obtain.

  12. Multiple Assessments of a First-Year Seminar Pilot

    ERIC Educational Resources Information Center

    Barton, Andrew; Donahue, Christiane

    2009-01-01

    First-year seminars have become common at liberal arts and other colleges across the United States. An accumulating body of research appears to demonstrate that this curricular element is associated with increased retention of students and is positively correlated with graduation rates, student adjustment and involvement, student satisfaction,…

  13. Authoring Teacher Development in a Graduate Seminar in Vietnam

    ERIC Educational Resources Information Center

    Baurain, Bradley

    2013-01-01

    The purpose of this narrative inquiry is to explore stories of teacher development experienced by English as a Foreign Language (EFL) teachers in a graduate seminar in Vietnam. The author was the instructor for the course, entitled "Literature and Language Teaching." Three types of data were collected: course documents, a professional…

  14. Educational Project on Indonesia. Fulbright Hayes Summer Seminar.

    ERIC Educational Resources Information Center

    Hribar, Georgeanne C.

    These lesson plans were developed by a participant in the Fulbright Summer Seminar on Indonesia. The materials provide information for teaching about economic and social factors affecting development of the region. There are four lessons in the packet. The lessons are: (1) "Centripetal and Centrifugal Forces" (geographical, historical, social,…

  15. Designing and Implementing a Capstone Gerontology Seminar: Synthesis and Action

    ERIC Educational Resources Information Center

    Sasser, Jennifer R.

    2005-01-01

    This paper focuses on the design and implementation of Gerontology: Synthesis and Action, the capstone seminar for the undergraduate and graduate certificate in gerontology program at Marylhurst University, a small, private liberal arts university in the Portland, Oregon metropolitan area. The institutional and programmatic context in which this…

  16. It's Your Move: Offering Seminars to Teach Strategy Games.

    ERIC Educational Resources Information Center

    Moore, Rhonda Bodine

    1994-01-01

    Gifted elementary students at the Center for Gifted Education in Columbia, Missouri, participated in a seminar designed to teach them the fundamentals of chess and other strategy board games. Students learned that beginning chess is accessible to everyone, learned problem solving and concentration, and created their own strategy board games. (JDD)

  17. An Evaluation of the Impact of an Undergraduate Research Seminar.

    ERIC Educational Resources Information Center

    Mauger, Karen; And Others

    1990-01-01

    Of 16 schools of pharmacy surveyed, 69 percent felt an undergraduate research seminar helped them generate interest in undergraduate research, and 13 percent believed it was useful in recruiting graduate students. Over half of students graduated went on to graduate programs, and 34 percent of students' course presentations resulted in…

  18. A Seminar Approach to T.A.G. Education.

    ERIC Educational Resources Information Center

    Hanson, Roger L.

    A former teacher of secondary talented and gifted (T.A.G.) students outlines principles and procedures of a seminar approach in which students assume the role of teachers. Procedures are seen to involve student interviews, student teacher conferences, and opportunities for independent work. Sample forms for the interview and project study aspects…

  19. Systemwide Student Tracking and Retention Programs. A Special Seminar.

    ERIC Educational Resources Information Center

    Berrian, Albert H., Ed.; Bonas, John E., Ed.

    Presentations at a seminar on systemwide tracking that grew out of efforts to promote implementation of South Carolina's desegregation plan are included. Two subjects were the focus: retention and the use of monitored developmental programs as a means of retention and of safeguarding quality. Essays include "Systemwide Student Tracking" (Delores…

  20. Papers of the Rural Community Development Seminar: Focus on Iowa.

    ERIC Educational Resources Information Center

    Iowa State Univ. of Science and Technology, Ames. Center for Agricultural and Rural Development.

    A seminar was conducted which provides a foundation upon which research, education, and action programs might be based as a state university brings its programs to focus more fully on the economic and social problems of rural areas. Papers presented covered the following subjects: objectives of community development, trends related to rural areas,…

  1. Some Mathematical Elements in a First-Year Seminar Course

    ERIC Educational Resources Information Center

    Pinter, Mike

    2007-01-01

    A first-year seminar general education course provides a good opportunity to search for mathematical topics associated with the popular culture represented in the course's required films and readings. We discuss mathematical connections to several books, including "Life of Pi" and "The Curious Incident of the Dog in the Night-Time," and to the…

  2. Development and Implementation of an Online Careers Seminar in Psychology

    ERIC Educational Resources Information Center

    Brinthaupt, Thomas M.

    2010-01-01

    Psychology departments are increasing their attention to providing career options and guidance for majors. I review the literature on the use of career courses in psychology and describe the development and implementation of an online careers seminar that provides psychology majors and minors with a wide range of information and resources. Student…

  3. Seminar on Sanitation for Restaurant Owners and Managers. Unit II.

    ERIC Educational Resources Information Center

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, unit two of the curriculum guide is organized to provide four hours of classroom instruction. Four major concepts are emphasized. The first concept, providing sanitary conditions in food service establishments, discusses safe use and storage of cleaning…

  4. Ventricular-Fold Dynamics in Human Phonation

    ERIC Educational Resources Information Center

    Bailly, Lucie; Bernardoni, Nathalie Henrich; Müller, Frank; Rohlfs, Anna-Katharina; Hess, Markus

    2014-01-01

    Purpose: In this study, the authors aimed (a) to provide a classification of the ventricular-fold dynamics during voicing, (b) to study the aerodynamic impact of these motions on vocal-fold vibrations, and (c) to assess whether ventricular-fold oscillations could be sustained by aerodynamic coupling with the vocal folds. Method: A 72-sample…

  5. Folding of a Cyclin Box

    PubMed Central

    Chemes, Lucía B.; Noval, María G.; Sánchez, Ignacio E.; de Prat-Gay, Gonzalo

    2013-01-01

    The retinoblastoma tumor suppressor (Rb) controls the proliferation, differentiation, and survival of cells in most eukaryotes with a role in the fate of stem cells. Its inactivation by mutation or oncogenic viruses is required for cellular transformation and eventually carcinogenesis. The high conservation of the Rb cyclin fold prompted us to investigate the link between conformational stability and ligand binding properties of the RbAB pocket domain. RbAB unfolding presents a three-state transition involving cooperative secondary and tertiary structure changes and a partially folded intermediate that can oligomerize. The first transition corresponds to unfolding of the metastable B subdomain containing the binding site for the LXCXE motif present in cellular and viral targets, and the second transition corresponds to the stable A subdomain. The low thermodynamic stability of RbAB translates into a propensity to rapidly oligomerize and aggregate at 37 °C (T50 = 28 min) that is suppressed by human papillomavirus E7 and E2F peptide ligands, suggesting that Rb is likely stabilized in vivo through binding to target proteins. We propose that marginal stability and associated oligomerization may be conserved for function as a “hub” protein, allowing the formation of multiprotein complexes, which could constitute a robust mechanism to retain its cell cycle regulatory role throughout evolution. Decreased stability and oligomerization are shared with the p53 tumor suppressor, suggesting a link between folding and function in these two essential cell regulators that are inactivated in most cancers and operate within multitarget signaling pathways. PMID:23632018

  6. Universities and Education in the Post-Recession Economy: Report of a Seminar Organised by Universities UK. Seminar Report

    ERIC Educational Resources Information Center

    Ryan, Conor

    2010-01-01

    Universities UK organised a seminar in Brighton in April 2010, bringing together vice-chancellors, researchers and policymakers to take a close look at the implications of the global and national economic crisis for both the UK economy and higher education. It also examined the changing nature of student demand in a post-recession economy. This…

  7. Chaperonin-mediated Protein Folding

    PubMed Central

    Horwich, Arthur L.

    2013-01-01

    We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments. PMID:23803606

  8. Atomic-level description of ubiquitin folding

    PubMed Central

    Piana, Stefano; Lindorff-Larsen, Kresten; Shaw, David E.

    2013-01-01

    Equilibrium molecular dynamics simulations, in which proteins spontaneously and repeatedly fold and unfold, have recently been used to help elucidate the mechanistic principles that underlie the folding of fast-folding proteins. The extent to which the conclusions drawn from the analysis of such proteins, which fold on the microsecond timescale, apply to the millisecond or slower folding of naturally occurring proteins is, however, unclear. As a first attempt to address this outstanding issue, we examine here the folding of ubiquitin, a 76-residue-long protein found in all eukaryotes that is known experimentally to fold on a millisecond timescale. Ubiquitin folding has been the subject of many experimental studies, but its slow folding rate has made it difficult to observe and characterize the folding process through all-atom molecular dynamics simulations. Here we determine the mechanism, thermodynamics, and kinetics of ubiquitin folding through equilibrium atomistic simulations. The picture emerging from the simulations is in agreement with a view of ubiquitin folding suggested from previous experiments. Our findings related to the folding of ubiquitin are also consistent, for the most part, with the folding principles derived from the simulation of fast-folding proteins, suggesting that these principles may be applicable to a wider range of proteins. PMID:23503848

  9. Improving protein fold recognition by random forest

    PubMed Central

    2014-01-01

    Background Recognizing the correct structural fold among known template protein structures for a target protein (i.e. fold recognition) is essential for template-based protein structure modeling. Since the fold recognition problem can be defined as a binary classification problem of predicting whether or not the unknown fold of a target protein is similar to an already known template protein structure in a library, machine learning methods have been effectively applied to tackle this problem. In our work, we developed RF-Fold that uses random forest - one of the most powerful and scalable machine learning classification methods - to recognize protein folds. Results RF-Fold consists of hundreds of decision trees that can be trained efficiently on very large datasets to make accurate predictions on a highly imbalanced dataset. We evaluated RF-Fold on the standard Lindahl's benchmark dataset comprised of 976 × 975 target-template protein pairs through cross-validation. Compared with 17 different fold recognition methods, the performance of RF-Fold is generally comparable to the best performance in fold recognition of different difficulty ranging from the easiest family level, the medium-hard superfamily level, and to the hardest fold level. Based on the top-one template protein ranked by RF-Fold, the correct recognition rate is 84.5%, 63.4%, and 40.8% at family, superfamily, and fold levels, respectively. Based on the top-five template protein folds ranked by RF-Fold, the correct recognition rate increases to 91.5%, 79.3% and 58.3% at family, superfamily, and fold levels. Conclusions The good performance achieved by the RF-Fold demonstrates the random forest's effectiveness for protein fold recognition. PMID:25350499

  10. Learning Protein Folding Energy Functions

    PubMed Central

    Guan, Wei; Ozakin, Arkadas; Gray, Alexander; Borreguero, Jose; Pandit, Shashi; Jagielska, Anna; Wroblewska, Liliana; Skolnick, Jeffrey

    2014-01-01

    A critical open problem in ab initio protein folding is protein energy function design, which pertains to defining the energy of protein conformations in a way that makes folding most efficient and reliable. In this paper, we address this issue as a weight optimization problem and utilize a machine learning approach, learning-to-rank, to solve this problem. We investigate the ranking-via-classification approach, especially the RankingSVM method and compare it with the state-of-the-art approach to the problem using the MINUIT optimization package. To maintain the physicality of the results, we impose non-negativity constraints on the weights. For this we develop two efficient non-negative support vector machine (NNSVM) methods, derived from L2-norm SVM and L1-norm SVMs, respectively. We demonstrate an energy function which maintains the correct ordering with respect to structure dissimilarity to the native state more often, is more efficient and reliable for learning on large protein sets, and is qualitatively superior to the current state-of-the-art energy function. PMID:25311546

  11. The 1977 Seminar on Education Finance: Problems and Prospects in Education Finance. Proceedings of a Seminar (Ottawa, Ontario, April 4-5, 1977).

    ERIC Educational Resources Information Center

    Canadian Teachers' Federation, Ottawa (Ontario).

    The theme of this seminar was the exploration of techniques and strategies for improving the funding of elementary and secondary education. The proceedings of the seminar included welcoming remarks by Michael Heron followed by the presentation "Problems and Prospects in Education Finance: Who Is Getting All the Money?" by Dr. Wilfred Brown.…

  12. European Environmental Education for Our Common Future. European Regional Seminar Report. Report from the Norwegian National Commission for UNESCO Seminar (Lillehammer, Norway, May 7-12, 1989).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Environmental Education Section.

    A seminar on the promotion of international cooperation and peace through environmental education (EE) within the framework of the UNESCO Associated Schools Project was held in Norway. The seminar was held against the background of increasing concern about environmental questions and an increasing awareness that the well-being and the future of…

  13. Privacy Rights in the 21st Century. Seminar Outlines [of the] Education Law Association Winter Seminar (Lake Tahoe, Nevada, March 21-24, 2002).

    ERIC Educational Resources Information Center

    Education Law Association, Dayton, OH.

    This collection of eight seminar outlines focuses on current privacy-rights issues in the arena of education. Seminar outlines include: (1) "The Transparency of Public School Employees' Professional and Personal Lives in the 21st Century: A Canadian Perspective," by Sam Carmen and Val Riewe; (2) "Common Law Privacy in Educational Settings," by…

  14. Russian-American Seminar on Critical Thinking and the Library. Papers from the Seminar (Moscow, Russia, June 1-5, 1992). Occasional Papers Nos. 200-201.

    ERIC Educational Resources Information Center

    Oberman, Cerise, Ed.; Kimmage, Dennis, Ed.

    The purpose behind the Russian-American Seminar on Critical Thinking was to bring together librarians from both countries to provide an East-West perspective on the issue of critical thinking. This document presents 16 papers from the seminar as well as introductory remarks from a Russian and an American participant. Papers are as follows: "The…

  15. Geometry of Miura-folded metamaterials

    PubMed Central

    Schenk, Mark; Guest, Simon D.

    2013-01-01

    This paper describes two folded metamaterials based on the Miura-ori fold pattern. The structural mechanics of these metamaterials are dominated by the kinematics of the folding, which only depends on the geometry and therefore is scale-independent. First, a folded shell structure is introduced, where the fold pattern provides a negative Poisson’s ratio for in-plane deformations and a positive Poisson’s ratio for out-of-plane bending. Second, a cellular metamaterial is described based on a stacking of individual folded layers, where the folding kinematics are compatible between layers. Additional freedom in the design of the metamaterial can be achieved by varying the fold pattern within each layer. PMID:23401549

  16. Paper Folding for the Mathematics Class.

    ERIC Educational Resources Information Center

    Johnson, Donovan A.

    Directions are given for folding paper to show geometric figures and relationships. Topics covered are folding the basic constructions, geometric concepts concerning triangles and quadrilaterals, circle relationships, products and factors, polygon constructions, symmetry, conic sections, and recreations. (DT)

  17. The parallel universe of RNA folding.

    PubMed

    Batey, R T; Doudna, J A

    1998-05-01

    How do large RNA molecules find their active conformations among a universe of possible structures? Two recent studies reveal that RNA folding is a rapid and ordered process, with surprising similarities to protein folding mechanisms.

  18. The SUPERCOMET 2 Project: Teacher Seminar and Teacher Guide

    NASA Astrophysics Data System (ADS)

    Engstrom, V.; Ireson, G.; Latal, H.; Mathelitsch, L.; Michelini, M.; Peeters, W.; Rath, G.

    2008-05-01

    The Leonardo da Vinci pilot projects SUPERCOMET (2001-2004) and SUPERCOMET 2 (2004-2007) developed and tested teacher training materials for active, minds-on learning of electromagnetism and superconductivity at the level of upper secondary school. New multimedia materials for the pupils supported the teacher materials, including a teacher seminar in 4 half-day modules detailing the scientific contents, teaching methods, using ICT in physics teaching and learning, online collaboration and further resources for exploring the selected topics. The aim of these projects were to improve the quality of physics teaching on a European level, involving a combined total of 45 partners in 16 countries, and conducting trials at 67 schools with approx. 230 teachers, 280 trainee teachers and 2200 pupils. New follow-up projects develop hands-on materials for carrying out the activities described in the teacher guide and seminars and additional teacher materials involving modelling, simulations and data logging.

  19. The 16th National Seminar on Crystallography: Abstract of papers

    NASA Astrophysics Data System (ADS)

    1982-03-01

    The abstracts of the papers received for this seminar are presented. These papers deal with the following subjects: Methods in Crystal Structure Analysis Including Computational Methods; Crystallography in Biology, Biohemistry, and Pharmacology; Atomic Scale Mechanisms, Physical Properties and Structures; Materials Science; Real and Ideal Crystals; Inorganic and Mineralogical Crystallography; Structures of Organic, Organic-Metallic Coordination Compounds and Polymers; Apparatus and Techniques; and Structural Methods Other Than Diffraction.

  20. NCI Alliance for Nanotechnology in Cancer - Tutorials and Seminar Series

    Cancer.gov

    View details about tutorials and seminars hosted by Alliance members and members of the cancer research community. These events provide a forum for sharing innovative perspectives on research and development efforts in the field of nanotechnology and their application to cancer diagnosis, treatment, and prevention. Also visit the Event Listing section to find scientific meetings and events where NCI Alliance for Nanotechnology in Cancer leaders and members are participating.

  1. Extracting Information from Folds in Rocks.

    ERIC Educational Resources Information Center

    Hudleston, Peter John

    1986-01-01

    Describes the three processes of folding in rocks: buckling, bending, and passive folding. Discusses how geometrical properties and strain distributions help to identify which processes produce natural folds, and also provides information about the mechanical properties of rocks, and the sense of shear in shear zones. (TW)

  2. Dynamics of Folds in the Plane

    ERIC Educational Resources Information Center

    Krylov, Nikolai A.; Rogers, Edwin L.

    2011-01-01

    Take a strip of paper and fold a crease intersecting the long edges, creating two angles. Choose one edge and consider the angle with the crease. Fold the opposite edge along the crease, creating a new crease that bisects the angle. Fold again, this time using the newly created crease and the initial edge, creating a new angle along the chosen…

  3. Surgical revision of the upper eyelid fold.

    PubMed

    Cies, W A; Baylis, H I

    1975-12-01

    We performed surgery on 107 patients primarily with blepharoptosis and eyelid fold abnormalities, between 1973 and 1974. Production of an eyelid fold at the time of an initial blepharoptosis procedure should be a primary goal. Lack of a distinct symmetrical upper eyelid fold constituted a cosmetic blemish and necessitated revision.

  4. Seminar 2.0: Learning With Skype and Video Podcasts

    NASA Astrophysics Data System (ADS)

    Wessel, Paul; Anderson, Tiffany; Austin, Regan; Benediktsdottir, Asdis; Chandler, Michael T.; Conley, Michaela M.; Kim, Seung-Sep; Michaud, Robert L.; Rumpf, M. Elise; Sleeper, Jonathan D.; Weiss, Jonathan R.

    2009-04-01

    Graduate seminars typically involve reviewing key papers, ranging from seminal contributions by pioneers to the latest cutting-edge results published in journals such as Nature, Science, and Geophysical Research Letters. Ideally, guest lecturers are invited to add specific expertise and stimulate discussions. However, the increasing costs for travel make this an expensive proposition. Recent improvements in free videoconferencing over the Internet make it possible to invite distant experts to participate in seminars without involving expensive and time-consuming travel. Tools to record video conferences allow anyone to combine narrations with slide presentations and prepare merged video files for distribution over the Internet (i.e., podcasts). This brief report discusses such an experiment in a graduate seminar on advanced plate tectonics in the Department of Geology and Geophysics at University of Hawai`i at Manoa's (UHM) School of Ocean and Earth Science and Technology (SOEST). The podcasts are freely available from iTunes (UHM; SOEST; Public Course Lectures) and from http://www.soest.hawaii.edu/pwessel/podcasts.

  5. A High School Project Seminar on Sea Level Rise

    NASA Astrophysics Data System (ADS)

    Seitz, M.; Bosch, W.

    2012-04-01

    In Bavaria the curriculum of the upper grade of high school includes a so called project seminar, running over one and a half year. The aims of the seminar are to let the pupils learn to work on a specific topic, to organize themselves in a team, to improve their soft skills and become familiar with the working life. The topic of the project seminar, jointly organized by the Bertold-Brecht-Gymnasium in Munich and the Deutsche Geodätische Forschungsinstitut (DGFI) was on the "Global sea level rise". A team of 13 pupils computed the mean sea level rise by using on the one hand altimetry data of TOPEX, Jason-1 and Jason2 and on the other hand data of globally distributed tide gauges, corrected for vertical crustal movements derived from GPS products. The results of the two independent approaches were compared with each other and discussed considering also statements and discussions found in press, TV, and the web. Finally, a presentation was prepared and presented at school.

  6. [Pan American seminar on education and health care].

    PubMed

    1978-01-01

    This is the Final Report of the Seminar, which was held at Caracas last February under the sponsorship of the World Federation of Medical Education and the World Health Organization, and organized by the Pan American Federation of Medical Schools and the Pan American Health Organization. The Seminar was attended by delegates from universities, ministries of education and health, social security administrations, medical educators, officers of national and international agencies, and other special guests from the Region of the Americas. These participants made up a broad-spectrum interinstitutional and interprofessional working group that brought an interdisciplinary analytical approach to the subjects dealt with. The Seminar examined the context of the relationship between education and health care, and discussed the following specific topics: need for coordination between education and health services, present systems of interrelationships, mechanisms for productive interrelations and a plan of action. The topics were considered in general sessions and then analyzed in discussion group meetings. The Report contains summaries of the presentations and commentaries on each subject and the consolidated reports of the discussion groups.

  7. 2012 ATOMIC AND MOLECULAR INTERACTIONS GORDON RESEARCH CONFERENCE AND GORDON RESEARCH SEMINAR, JULY 15-20, 2012

    SciTech Connect

    Zwier, Timothy

    2012-07-20

    At the 2012 Atomic and Molecular Interactions Gordon Conference, there will be talks in several broadly defined and partially overlapping areas:  Intramolecular and single-collision reaction dynamics;  Photophysics and photochemistry of excited states;  Clusters, aerosols and solvation;  Interactions at interfaces;  Conformations and folding of large molecules;  Interactions under extreme conditions of temperature and pressure. The theme of the Gordon Research Seminar on Atomic & Molecular Interactions, in keeping with the tradition of the Atomic and Molecular Interactions Gordon Research Conference, is far-reaching and involves fundamental research in the gas and condensed phases along with application of these ideas to practical chemical fields. The oral presentations, which will contain a combination of both experiment and theory, will focus on four broad categories:  Ultrafast Phenomena;  Excited States, Photoelectrons, and Photoions;  Chemical Reaction Dynamics;  Biomolecules and Clusters.

  8. Understanding Protein Non-Folding

    PubMed Central

    Uversky, Vladimir N.; Dunker, A. Keith

    2010-01-01

    This review describes the family of intrinsically disordered proteins, members of which fail to form rigid 3-D structures under physiological conditions, either along their entire lengths or only in localized regions. Instead, these intriguing proteins/regions exist as dynamic ensembles within which atom positions and backbone Ramachandran angles exhibit extreme temporal fluctuations without specific equilibrium values. Many of these intrinsically disordered proteins are known to carry out important biological functions which, in fact, depend on the absence of specific 3-D structure. The existence of such proteins does not fit the prevailing structure-function paradigm, which states that unique 3-D structure is a prerequisite to function. Thus, the protein structure-function paradigm has to be expanded to include intrinsically disordered proteins and alternative relationships among protein sequence, structure, and function. This shift in the paradigm represents a major breakthrough for biochemistry, biophysics and molecular biology, as it opens new levels of understanding with regard to the complex life of proteins. This review will try to answer the following questions: How were intrinsically disordered proteins discovered? Why don't these proteins fold? What is so special about intrinsic disorder? What are the functional advantages of disordered proteins/regions? What is the functional repertoire of these proteins? What are the relationships between intrinsically disordered proteins and human diseases? PMID:20117254

  9. Folding of viscous sheets and filaments

    NASA Astrophysics Data System (ADS)

    Skorobogatiy, M.; Mahadevan, L.

    2000-12-01

    We consider the nonlinear folding behavior of a viscous filament or a sheet under the influence of an external force such as gravity. Everyday examples of this phenomenon are provided by the periodic folding of a sheet of honey as it impinges on toast, or the folding of a stream of shampoo as it falls on one's hand. To understand the evolution of a fold, we formulate and solve a free-boundary problem for the phenomenon, give scaling laws for the size of the folds and the frequency with which they are laid out, and verify these experimentally.

  10. 2nd U.S.-Japan Seminar on “High-Pressure Research: Applications in Geophysics”

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    The second U.S.-Japan seminar on ‘High-Pressure Research: Applications in Geophysics’ was held in Hakone, Japan, January 12-15, 1981, under the auspices of the U.S.-Japan Cooperative Science Program between the Japan Society for the Promotion of Science (JSPS) and the U.S. National Science Foundation (NSF). The coconvenors were Syun-iti Akimoto (Japan) and Murli H. Manghnani (USA). The first such seminar was held in Honolulu, Hawaii, in 1976. Like the Hawaii seminar, the Hakone seminar was a tremendous success.

  11. Anatomy and Histology of an Epicanthal Fold.

    PubMed

    Park, Jae Woo; Hwang, Kun

    2016-06-01

    The aim of this study is to elucidate the precise anatomical and histological detail of the epicanthal fold.Thirty-two hemifaces of 16 Korean adult cadavers were used in this study (30 hemifaces with an epicanthal fold, 2 without an epicanthal fold). In 2 patients who had an epicanthoplasty, the epicanthal folds were sampled.In a dissection, the periorbital skin and subcutaneous tissues were removed and the epicanthal fold was observed in relation to each part of the orbicularis oculi muscle. Specimens including the epicanthal fold were embeddedin in paraffin, sectioned at 10 um, and stained with Hematoxylin-Eosin. The horizontal section in the level of the paplebral fissure was made and the prepared slides were observed under a light microscope.In the specimens without an epicanthal fold, no connection between the upper preseptal muscle and the lower preseptal muscle was found. In the specimens with an epicanthal fold, a connection of the upper preseptal muscle to the lower preseptal muscle was observed. It was present in all 15 hemifaces (100%). There was no connection between the pretarsal muscles. In a horizontal section, the epicanthal fold was composed of 3 compartments: an outer skin lining, a core structure, and an innerskin lining. The core structure was mainly composed of muscular fibers and fibrotic tissue and they were intermingled.Surgeons should be aware of the anatomical details of an epicanthal fold. In removing or reconstructing an epicanthal fold, the fibromuscular core band should also be removed or reconstructed.

  12. Geomorphology and fold growth, southern Tunisia.

    NASA Astrophysics Data System (ADS)

    Ahamadi, R.; Mercier, E.; Ouali, J.; van Vliet-Lanoë, B.; Mansy, J. L.; Launeau, P.; Rekis, F.

    2003-04-01

    At the northern edge of the Gafsa basin, a fold belt, the Metlaoui chain mostly rised from the Upper Miocene till today [1]. This region, endoreic since the Oligocene, is for lithologic and climate reasons a good laboratory to test various theories concerning fold growth. The origin of the fold belt is link to a main detachment level at the base of the Jurassic series (seismic profiles). The folding is facilitate with few strong calcareous beds by the dominance of soft lithologic series. This enhances the sliding along secondary detachment levels. Geomorphological, hydrological and chronological arguments prove that the folds mostly deformed as a "fault propagation fold" [2]. Furthermore, detailed field observations validate several features first observed by modelling of "fault propagation fold": 1) the stability of the roof of the fold, 2) the propagation of a knock-fold in front of the fold, disturbing the shape of pediments [3] and 3) the backward migration and extent of the backslope of the fold, in association with a backward migration of the depot centre of the syntectonic sedimentation. [1] Outtani, F., B. Addoum, E. Mercier, D. Frizon de Lamotte, J. Andrieux, Tectonophysics, 249, 233-248, 1995. [2] Suppe, J., and D.A. Medwedeff, , Eclogae geol. Helv., 83(3), 409-454, 1990. [3] Rafini S. and E. Mercier (2002). Sedimentary Geology, 146, 75-89

  13. Stress and strain evolution of folding rocks

    NASA Astrophysics Data System (ADS)

    Llorens, Maria-Gema; Griera, Albert; Bons, Paul; Gomez-Rivas, Enrique; Weikusat, Ilka

    2015-04-01

    One of the main objectives of structural geology is to unravel rock deformation histories. Fold shapes can be used to estimate the orientation and amount of strain associated with folding. However, much more information on rheology and kinematics can potentially be extracted from fold geometries (Llorens et al., 2013a). We can study the development of folds, quantify the relationships between the different parameters that determine their geometries and estimate their mechanical evolution. This approach allows us to better understand and predict not only rock but also ice deformation. One of the main parameters in fold development is the viscosity contrast between the folding layer and the matrix in which it is embedded (m), since it determines the initial fold wavelength and the amplification rate of the developing folds. Moreover, non-linear viscous rheology influences fold geometry too (Llorens et al., 2013b). We present a series of 2-dimensional simulations of folding of viscous single layers in pure and simple shear. We vary different parameters in order to compare and determine their influence on the resulting fold patterns and the associated mechanical response of the material. To perform these simulations we use the software platform ELLE (www.elle.ws) with the non-linear viscous finite element code BASIL. The results show that layers thicken at the beginning of deformation in all simulations, and visible folds start earlier or later depending on the viscosity contrast. When folds start to nucleate the layer maximum shear strain decreases, moving away from the theoretical trend for homogeneous strain (no folding). This allows the accurate determination of the onset of folding. Maximum deviatoric stresses are higher in power-law than in linear-viscosity materials, and it is initially double in pure shear than in simple shear conditions. Therefore, folding a competent layer requires less work in simple than in pure shear. The maximum deviatoric stress

  14. Reduced alphabet for protein folding prediction.

    PubMed

    Huang, Jitao T; Wang, Titi; Huang, Shanran R; Li, Xin

    2015-04-01

    What are the key building blocks that would have been needed to construct complex protein folds? This is an important issue for understanding protein folding mechanism and guiding de novo protein design. Twenty naturally occurring amino acids and eight secondary structures consist of a 28-letter alphabet to determine folding kinetics and mechanism. Here we predict folding kinetic rates of proteins from many reduced alphabets. We find that a reduced alphabet of 10 letters achieves good correlation with folding rates, close to the one achieved by full 28-letter alphabet. Many other reduced alphabets are not significantly correlated to folding rates. The finding suggests that not all amino acids and secondary structures are equally important for protein folding. The foldable sequence of a protein could be designed using at least 10 folding units, which can either promote or inhibit protein folding. Reducing alphabet cardinality without losing key folding kinetic information opens the door to potentially faster machine learning and data mining applications in protein structure prediction, sequence alignment and protein design.

  15. Some aspects of vocal fold bowing.

    PubMed

    Tanaka, S; Hirano, M; Chijiwa, K

    1994-05-01

    Bowing of the vocal fold frequently occurs in patients with vocal fold paralysis (VFP), those with sulcus vocalis, and those who have had laser surgery. Additionally, there are vocal folds that present bowing with no noticeable organic lesion. For the purpose of investigating the causes and mechanisms of vocal fold bowing, consecutive fiberscopic videorecordings of 127 patients with VFP, 33 with sulcus vocalis, 33 with laser surgery, and 33 with dysphonia having no clinically noticeable organic lesion were reviewed. Sixty-nine percent of the paralyzed vocal folds had bowing, and the occurrence of bowing was significantly related to the activity of the thyroarytenoid muscle as measured by electromyography. The cricothyroid activity had no significant relationship to vocal fold bowing. All vocal folds with sulcus presented with bowing. Thirty-five percent of the vocal folds that had had laser surgery had bowing. The extent of tissue removal was closely related to the occurrence of bowing. Twelve cases with no organic lesion had vocal fold bowing. Of these 12 patients, 8 were male and 9 were older than 60 years. Some aging process in the mucosa was presumed to be the cause of the bowing in this age group of patients without clinically noticeable organic lesions. Causes of vocal fold bowing in the younger group of patients without organic lesions were not determined in this study.

  16. Some aspects of vocal fold bowing.

    PubMed

    Tanaka, S; Hirano, M; Chijiwa, K

    1994-05-01

    Bowing of the vocal fold frequently occurs in patients with vocal fold paralysis (VFP), those with sulcus vocalis, and those who have had laser surgery. Additionally, there are vocal folds that present bowing with no noticeable organic lesion. For the purpose of investigating the causes and mechanisms of vocal fold bowing, consecutive fiberscopic videorecordings of 127 patients with VFP, 33 with sulcus vocalis, 33 with laser surgery, and 33 with dysphonia having no clinically noticeable organic lesion were reviewed. Sixty-nine percent of the paralyzed vocal folds had bowing, and the occurrence of bowing was significantly related to the activity of the thyroarytenoid muscle as measured by electromyography. The cricothyroid activity had no significant relationship to vocal fold bowing. All vocal folds with sulcus presented with bowing. Thirty-five percent of the vocal folds that had had laser surgery had bowing. The extent of tissue removal was closely related to the occurrence of bowing. Twelve cases with no organic lesion had vocal fold bowing. Of these 12 patients, 8 were male and 9 were older than 60 years. Some aging process in the mucosa was presumed to be the cause of the bowing in this age group of patients without clinically noticeable organic lesions. Causes of vocal fold bowing in the younger group of patients without organic lesions were not determined in this study. PMID:8179251

  17. Kinetic partitioning mechanism of HDV ribozyme folding

    SciTech Connect

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing

    2014-01-14

    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  18. Kinetic partitioning mechanism of HDV ribozyme folding

    NASA Astrophysics Data System (ADS)

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing

    2014-01-01

    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  19. Folding of synthetic homogeneous glycoproteins in the presence of a glycoprotein folding sensor enzyme.

    PubMed

    Dedola, Simone; Izumi, Masayuki; Makimura, Yutaka; Seko, Akira; Kanamori, Akiko; Sakono, Masafumi; Ito, Yukishige; Kajihara, Yasuhiro

    2014-03-10

    UDP-glucose:glycoprotein glucosyltransferase (UGGT) plays a key role in recognizing folded and misfolded glycoproteins in the glycoprotein quality control system of the endoplasmic reticulum. UGGT detects misfolded glycoproteins and re-glucosylates them as a tag for misfolded glycoproteins. A flexible model to reproduce in vitro folding of a glycoprotein in the presence of UGGT in a mixture containing correctly folded, folding intermediates, and misfolded glycoproteins is described. The data demonstrates that UGGT can re-glucosylate all intermediates in the in vitro folding experiments, thus indicating that UGGT inspects not only final folded products, but also the glycoprotein folding intermediates.

  20. Protein folding at atomic resolution: analysis of autonomously folding supersecondary structure motifs by nuclear magnetic resonance.

    PubMed

    Sborgi, Lorenzo; Verma, Abhinav; Sadqi, Mourad; de Alba, Eva; Muñoz, Victor

    2013-01-01

    The study of protein folding has been conventionally hampered by the assumption that all single-domain proteins fold by an all-or-none process (two-state folding) that makes it impossible to resolve folding mechanisms experimentally. Here we describe an experimental method for the thermodynamic analysis of protein folding at atomic resolution using nuclear magnetic resonance (NMR). The method is specifically developed for the study of small proteins that fold autonomously into basic supersecondary structure motifs, and that do so in the sub-millisecond timescale (folding archetypes). From the NMR experiments we obtain hundreds of atomic unfolding curves that are subsequently analyzed leading to the determination of the characteristic network of folding interactions. The application of this approach to a comprehensive catalog of elementary folding archetypes holds the promise of becoming the first experimental approach capable of unraveling the basic rules connecting protein structure and folding mechanism. PMID:22987355

  1. On the universe of protein folds.

    PubMed

    Kolodny, Rachel; Pereyaslavets, Leonid; Samson, Abraham O; Levitt, Michael

    2013-01-01

    In the fifty years since the first atomic structure of a protein was revealed, tens of thousands of additional structures have been solved. Like all objects in biology, proteins structures show common patterns that seem to define family relationships. Classification of proteins structures, which started in the 1970s with about a dozen structures, has continued with increasing enthusiasm, leading to two main fold classifications, SCOP and CATH, as well as many additional databases. Classification is complicated by deciding what constitutes a domain, the fundamental unit of structure. Also difficult is deciding when two given structures are similar. Like all of biology, fold classification is beset by exceptions to all rules. Thus, the perspectives of protein fold space that the fold classifications offer differ from each other. In spite of these ambiguities, fold classifications are useful for prediction of structure and function. Studying the characteristics of fold space can shed light on protein evolution and the physical laws that govern protein behavior.

  2. Protein Vivisection Reveals Elusive Intermediates in Folding

    SciTech Connect

    Zheng, Zhongzhou; Sosnick, Tobin R.

    2010-05-25

    Although most folding intermediates escape detection, their characterization is crucial to the elucidation of folding mechanisms. Here, we outline a powerful strategy to populate partially unfolded intermediates: A buried aliphatic residue is substituted with a charged residue (e.g., Leu {yields} Glu{sup -}) to destabilize and unfold a specific region of the protein. We applied this strategy to ubiquitin, reversibly trapping a folding intermediate in which the {beta}5-strand is unfolded. The intermediate refolds to a native-like structure upon charge neutralization under mildly acidic conditions. Characterization of the trapped intermediate using NMR and hydrogen exchange methods identifies a second folding intermediate and reveals the order and free energies of the two major folding events on the native side of the rate-limiting step. This general strategy may be combined with other methods and have broad applications in the study of protein folding and other reactions that require trapping of high-energy states.

  3. Protein vivisection reveals elusive intermediates in folding.

    PubMed

    Zheng, Zhongzhou; Sosnick, Tobin R

    2010-04-01

    Although most folding intermediates escape detection, their characterization is crucial to the elucidation of folding mechanisms. Here, we outline a powerful strategy to populate partially unfolded intermediates: A buried aliphatic residue is substituted with a charged residue (e.g., Leu-->Glu(-)) to destabilize and unfold a specific region of the protein. We applied this strategy to ubiquitin, reversibly trapping a folding intermediate in which the beta5-strand is unfolded. The intermediate refolds to a native-like structure upon charge neutralization under mildly acidic conditions. Characterization of the trapped intermediate using NMR and hydrogen exchange methods identifies a second folding intermediate and reveals the order and free energies of the two major folding events on the native side of the rate-limiting step. This general strategy may be combined with other methods and have broad applications in the study of protein folding and other reactions that require trapping of high-energy states.

  4. Acquired retinal folds in the cat.

    PubMed

    MacMillan, A D

    1976-06-01

    Retinal folds were found in 5 cats. The apparent cause of the folding was varied: in 1 cat the folds appeared after a localized retinal detachment; in 2 cats the condition accompanied other intraocular abnormalities associated with feline infectious peritonitis; 1 cat had active keratitis, and the retinal changes were thought to have been injury related; and 1 cat, bilaterally affected, had chronic glomerulonephritis. PMID:945253

  5. COS Side 2 NUV MAMA Fold Test

    NASA Astrophysics Data System (ADS)

    Bacinski, John

    2013-10-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {13128} during Cycle 20.This proposal is an exact duplication of nominal COS MAMA Fold Analysis {proposal 13128, Cycle 20}. Any changes 13128 or subsequent cycle submissions should be reflected in this proposal and vice versa.

  6. Distinguishing between sequential and nonsequentially folded proteins: implications for folding and misfolding.

    PubMed Central

    Tsai, C. J.; Maizel, J. V.; Nussinov, R.

    1999-01-01

    We describe here an algorithm for distinguishing sequential from nonsequentially folding proteins. Several experiments have recently suggested that most of the proteins that are synthesized in the eukaryotic cell may fold sequentially. This proposed folding mechanism in vivo is particularly advantageous to the organism. In the absence of chaperones, the probability that a sequentially folding protein will misfold is reduced significantly. The problem we address here is devising a procedure that would differentiate between the two types of folding patterns. Footprints of sequential folding may be found in structures where consecutive fragments of the chain interact with each other. In such cases, the folding complexity may be viewed as being lower. On the other hand, higher folding complexity suggests that at least a portion of the polypeptide backbone folds back upon itself to form three-dimensional (3D) interactions with noncontiguous portion(s) of the chain. Hence, we look at the mechanism of folding of the molecule via analysis of its complexity, that is, through the 3D interactions formed by contiguous segments on the polypeptide chain. To computationally splice the structure into consecutively interacting fragments, we either cut it into compact hydrophobic folding units or into a set of hypothetical, transient, highly populated, contiguous fragments ("building blocks" of the structure). In sequential folding, successive building blocks interact with each other from the amino to the carboxy terminus of the polypeptide chain. Consequently, the results of the parsing differentiate between sequentially vs. nonsequentially folded chains. The automated assessment of the folding complexity provides insight into both the likelihood of misfolding and the kinetic folding rate of the given protein. In terms of the funnel free energy landscape theory, a protein that truly follows the mechanism of sequential folding, in principle, encounters smoother free energy barriers

  7. Brazilian History and Culture Program, June 27 - August 2, 1992. Fulbright Hays Seminars Abroad Program.

    ERIC Educational Resources Information Center

    1992

    Sixteen participants in the Fulbright-Hays Seminar on the history and culture of Brazil traveled throughout Brazil from June 27 through August 2, 1992. At the end of the seminar 14 participants developed curriculum projects. Presented alphabetically by author, the 14 curricular projects cover aspects of Brazilian life and culture. Riva…

  8. NCSALL Seminar Guide: Establishing an Evidence-Based Adult Education System

    ERIC Educational Resources Information Center

    Parker, Hazel; Smith, Cristine; Bingman, Beth

    2004-01-01

    This Seminar guide is part of NCSALL's (National Center for the Study of Adult Learning and Literacy's) effort to help connect research and practice in the field of adult education and family literacy. The purpose of the three-hour seminar is to help practitioners, program directors, state staff, and other policymakers read and discuss NCSALL's…

  9. 1972 Minnesota NCTE (National Council of Teachers of English) Seminar on Research in English Education.

    ERIC Educational Resources Information Center

    Purves, Alan C., Ed.

    1973-01-01

    The articles in this journal relate the conference experience at the 1972 Minnesota National Council of Teachers of English (NCTE) Seminar on Research in English Education. Articles include "The New Research" by Peter S Rosenbaum (discussing the influence of the seminar experience and how it can precipitate new research); "Research in the Teaching…

  10. Critical Conversations about Big Ideas in Art Using Paideia Seminar: A Focus on Early Elementary Settings

    ERIC Educational Resources Information Center

    Paul, Kristina Ayers; Tay, Juliana

    2016-01-01

    Paideia Seminar is a method for facilitating Socratic discussions about different types of texts, whether they be texts in the literal sense of the word or any other object that represents ideas or values. In this article, we describe how teachers can implement Paideia Seminar to spark deep thinking and rich discussion among early elementary…

  11. Building the Social Movement. Papers from an Invitational Seminar (Montreal, Canada, June 4-6, 1986).

    ERIC Educational Resources Information Center

    British Columbia Univ., Vancouver. Centre for Continuing Education.

    Thirty leaders from six Canadian social movements were invited to participate in an invitational seminar that was designed to explore strategies for building stronger collaboration among social movements in the Canadian community. This collection contains the following papers from that seminar: "Building the Social Movement: An Introduction," by…

  12. Seminar on Subminimum Wage for Youth. Executive Summary (New York, New York, April 21, 1981).

    ERIC Educational Resources Information Center

    1981

    A seminar was held to examine the merits and feasibility of a subminimum wage for youth. Throughout the seminar panelists expressed general agreement on the fact that most youth want to work as well as on the value or potential value of employment and training programs, including the Comprehensive Employment and Training Act (CETA) programs. In…

  13. Methods of Comparative Androgogy: An International Expert Seminar (Bamberg, Germany, September 24-27, 1995).

    ERIC Educational Resources Information Center

    Charters, Margaret A.

    A seminar collected, shared, and discussed the consensus on definitions, standards, methods, and current problems in research methodology in comparative andragogy. Alfred Hierold opened the seminar with a brief history of the evolution of the University of Bamberg. The opening session focused on the importance of the researcher as a tool in…

  14. Seminar on Foci for Progress in Scientific Publications: A Summary and Final Report.

    ERIC Educational Resources Information Center

    Battelle Memorial Inst., Columbus, OH.

    A one-day seminar was convened on November 4, 1969, to consider problems involved in communicating scientific information and the progress that has been made in improving the scientific publication mechanism. Thirty participants representing different types of information producers, users, and organizations contributed to the seminar discussion.…

  15. Complexity Theory 101 for Educators: A Fictional Account of a Graduate Seminar

    ERIC Educational Resources Information Center

    McMurtry, Angus

    2008-01-01

    The following fictional account of a seminar on complexity science and its relevance for education makes use of several real events. The first is an actual seminar that took place during the spring of 2005, in the Department of Secondary Education at the University of Alberta. The second is the collective creation of the Complexity and Education…

  16. Cinemeducation in Psychiatry: A Seminar in Undergraduate Medical Education Combining a Movie, Lecture, and Patient Interview

    ERIC Educational Resources Information Center

    Kuhnigk, Olaf; Schreiner, Julia; Reimer, Jens; Emami, Roya; Naber, Dieter; Harendza, Sigrid

    2012-01-01

    Objective: Psychiatric educators are often faced with students' negative attitudes toward psychiatry. A new type of seminar has been established in order to enable students to gain a deeper understanding of psychiatric illness. Method: A "cinemeducation seminar," combining a movie, a lecture, and a patient interview, has been established as part…

  17. Writing Seminars in the Content Area: In Search of Hemingway, Salinger, and Steinbeck.

    ERIC Educational Resources Information Center

    Workman, Brooke

    Intended for high school and college literature instructors, this book contains materials for intensive semester-long seminars on the lives and works of three American authors: Ernest Hemingway, J. D. Salinger, and John Steinbeck. Each seminar revolves around seven papers the students are required to write and defend aloud in front of the rest of…

  18. Federal Focus on Education: Transcript of Proceedings. Education Seminar. (Washington, D.C., April 18, 1974)

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC.

    This report of the education seminar held before media representatives contains statements by policy-level officials and technical experts in the Department of Health, Education and Welfare. Formal presentations are followed by question and answer sessions. Participants in the seminar include Lewis M. Helm, Assistant Secretary for Public Affairs;…

  19. Spring Seminars Report. Information Technology and Education Programme. Occasional Paper ITE/3/85.

    ERIC Educational Resources Information Center

    Lewis, R.

    This report contains excerpts from papers and summaries of discussions and program actions carried out during a series of seminars held to establish research priorities under the Information Technology and Education Programme (ITE) in the United Kingdom. The seminar on "Information Technology" (IT) included Kenneth Ruthven's consideration of IT…

  20. Adaptation and Integration of Permanent Immigrants Seminar (4th, Geneva, Switzerland, May 8-11, 1979).

    ERIC Educational Resources Information Center

    International Migration, 1979

    1979-01-01

    This document contains working papers prepared for a seminar on Adaptation and Integration of Permanent Immigrants, along with general and specific recommendations formulated by seminar participants. Conclusions and recommendations from each paper are presented in English, French, and Spanish; the conference papers themselves are presented only in…

  1. Early Child Development. Innocenti Global Seminar (Florence, Italy, June 12-30, 1989). Summary Report.

    ERIC Educational Resources Information Center

    Landers, Cassie

    The first Innocenti Global Seminar, which was sponsored by the United Nations Children's Fund (UNICEF), investigated the topic of Early Child Development (ECD). This summary report focuses on the three objectives of the seminar, which were to: (1) review critical issues in the field of child development so as to provide a rationale for investing…

  2. BAAL/CUP Seminars 2013/Text Trajectories--Developing Dynamic Approaches to Textual Analysis

    ERIC Educational Resources Information Center

    Maybin, Janet; Lillis, Theresa

    2015-01-01

    This seminar took place on 19 April, 2013 at the Centre for Language and Communication, Faculty of Language and Education Studies, The Open University. The seminar was coordinated by Janet Maybin and Theresa Lillis and there were 28 participants, including four postgraduate students, from universities in Britain, Belgium and South Africa.

  3. The Influence of a Collaborative Doctoral Seminar on Emerging Teacher Educator-Researchers

    ERIC Educational Resources Information Center

    Dinkelman, Todd; Cuenca, Alexandar; Butler, Brandon; Elfer, Charles; Ritter, Jason; Powell, Dave; Hawley, Todd

    2012-01-01

    Over a 7-year period, graduate teaching assistants participated in a teacher education doctoral seminar designed to develop emergent scholarship and practice in teacher education. Six former students in the seminar, all now assistant professors, joined Dinkelman in an open-ended, far-ranging, month-long conversation captured in a threaded, online…

  4. Seminar on Factual and Numerical Data Banks. Final Report (Rabat, Morocco, February 21-24, 1984).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific and Cultural Organization, Paris (France). General Information Programme.

    The proceedings of a seminar on factual and numerical data banks are described. Seminar objectives were to: (1) make potential users aware of the value of data banks in their respective disciplines and inform them of the tools available; (2) identify national and regional data bank requirements; and (3) define a strategy for development in this…

  5. An Examination of the Impact of a Freshman Seminar Course on Student Academic Outcomes.

    ERIC Educational Resources Information Center

    Raymond, Lanette; Napoli, Anthony R.

    1998-01-01

    Assesses the correlation between completion of a freshman seminar course at a community college and subsequent persistence and achievement. Indicates that receiving a grade of "C" or better is positively correlated with subsequent academic success. States that the results do not identify which elements of the seminar contributed most to this…

  6. Seminars for Separated/Divorced: An Educational Approach to Postdivorce Adjustment

    ERIC Educational Resources Information Center

    Welch, Gary J.; Granvold, Donald K.

    1977-01-01

    This paper describes a seminar approach to postdivorce adjustment. Topical content areas covered in the seven-week seminars are discussed. The interaction of leader-guided problem solving and participant input is addressed along with a series of preliminary conclusions reached concerning the efficacy of this approach to treatment. (Author)

  7. Dynamics of Community Board Membership. Proceedings of a Seminar, May 19, 1979.

    ERIC Educational Resources Information Center

    Native American Educational Services, Inc., Chicago, IL.

    Proceedings of a seminar on the role of American Indian agency boards of directors and executives are reported in this document. Sponsored by the Native American Educational Services (NAES), the purpose of the seminar as presented in the introduction was "to help boards of directors and executives come to grips with the ramifications of their…

  8. O Taste and See: A Commemorative History of the Wye Seminars

    ERIC Educational Resources Information Center

    Holyer, Robert

    2014-01-01

    Each summer, faculty and academic deans from institutions across the country make their way to the Wye River campus of the Aspen Institute on the Eastern Shore of Maryland for a weeklong seminar. Described as professional development, it often turns out to be much more. The Wye Seminars have at their core a collection of classic texts--from Plato…

  9. Media Technologies and Language Learning. Proceedings of an IRAAL Seminar (Dublin, Ireland, November 25, 1989).

    ERIC Educational Resources Information Center

    Little, David, Ed.; O Meadhra, Bebhinn, Ed.

    A seminar sponsored by the Irish Association for Applied Linguistics on the role of media and media technologies in second and foreign language learning is reported. The organization of this report reflects the program of the seminar. Four plenary papers established some broad applied linguistic perspectives and presented an overview of recent…

  10. Knowledge and attitudes about smoking in medical students before and after a tobacco seminar.

    PubMed

    Chung, T W; Lam, T H; Cheng, Y H

    1996-07-01

    A 3-hour seminar on tobacco was introduced to second year (pre-clinical) medical students in Hong Kong in 1994. The differences in knowledge and attitudes were measured by a self-administered and anonymous questionnaire with 14 items before the seminar (n = 145), and again 2 weeks after the seminar (n = 151). The students also completed an evaluation form at the end of the seminar. Before the seminar, the students were most deficient in their knowledge on the exact magnitude of the risks from smoking and on the risks from smoking relative to the risks from air pollution and asbestos. After the seminar, their knowledge increased significantly (P < 0.005). As for attitudes, in the pre-test 35% strongly agreed that tobacco advertising should be completely banned, and 50% did so in the post-test (P = 0.02). The corresponding figures for banning of all forms of tobacco promotion were 26% and 43% (P < 0.005). In the pre-test, one in four students strongly disagreed that doctor's advice to their patients to stop smoking is totally ineffective, with this proportion increasing to 70% in the post-test (P < 0.005). The majority of the students stated that the seminar was useful. The preclinical medical curriculum should, at the very least, include a tobacco seminar. Our survey shows that it is effective in improving students' knowledge and attitudes on tobacco control. PMID:8949541

  11. Integrating the Freshman Seminar with a Developmental Reading-Writing Course.

    ERIC Educational Resources Information Center

    Meyer, Margaret Dietz

    First-year students taking developmental courses need the kind of guidance a freshman seminar can provide when the advice is directly relevant to their progress. An alternative to assigning a heterogeneous group of students to an academic advisor is to offer a course which enriches the key elements of a freshman seminar while applying the standard…

  12. A new methodology for teaching clinical reasoning skills: problem solving clinical seminars.

    PubMed

    Struyf, E; Beullens, J; Van Damme, B; Janssen, P; Jaspaert, H

    2005-06-01

    In the final year of the medical curriculum of the Faculty of Medicine of the Katholieke Universiteit Leuven (Belgium), a new methodology for teaching clinical skills was introduced: Problem Solving Clinical Seminars (PSCS). Two eight-week series of 70 seminars were offered. Students prepared for the seminars in groups of five students who worked on one or more clinical cases followed by half-open questions. Additional information was collected individually. At the clinical seminar the solutions were presented and discussed, guided by a clinical teacher. A questionnaire was administered to investigate whether students perceive the new type of clinical seminars as a powerful learning environment. Students were satisfied with the new methodology. The importance of the postulated educational aspects--preparation, clinical case and the seminar--was confirmed. The preparation phase (self-study and group work) and the clinical seminar were experienced as two separate and important learning events. The implementation of the problem solving clinical seminars is considered by students to be a powerful learning environment and therefore a broader applicability of the PSCS methodology is recommended.

  13. Seminar for Preparation of Professional Personnel for Vocational-Technical Education. Final Report.

    ERIC Educational Resources Information Center

    Dillon, Roy D.; Horner, James T.

    Seminar participants included college administrative officers, state vocational education directors, vocational-technical teacher educators, and Office of Education staff. The purpose of the June, 1968 seminar was to consider strategies for resolving critical vocational education personnel supply and demand problems. Presentations included in the…

  14. Lasting Connections: A Case Study of Relationships Formed during a First-Year Seminar Course

    ERIC Educational Resources Information Center

    Enke, Kathryn A. E.

    2011-01-01

    This article investigates the evolution of friendships formed during a first-year seminar for honors students enrolled in a private liberal arts college. Through an electronic survey and interviews with former students who had participated in the seminar course six years prior to the research, this case study examined why some friendships were…

  15. Examining the Influence of a Support Seminar on Pre-Service Teachers' Preparedness for Student Teaching

    ERIC Educational Resources Information Center

    Polly, Drew; Frazier, Joyce; Hopper, Cindy; Chapman, Marvin; Wells, Richard

    2012-01-01

    This study examined the influence of a semester-long seminar on student teachers' perceptions of their preparedness for student teaching. Eighteen pre-service teachers in elementary (grades K-6) and middle grades (grades 6-8) participated in the seminar. Seventeen pre-service teachers from the same programs were used as a matched comparison group.…

  16. The Impact of Peer Observation and Feedback on Technical Seminar Presentations: A Constructive Model

    ERIC Educational Resources Information Center

    Vani, V. Vijaya

    2015-01-01

    The present paper attempts to showcase the need and importance of peer observation and feedback in developing technical seminar presentation skills of the students at tertiary level. The paper endeavors to know whether a structured format will help students to know what they have to observe in the seminar presentations to give constructive…

  17. Investigating a First-Year Seminar as an Anchor Course in Learning Communities

    ERIC Educational Resources Information Center

    Friedman, Daniel B.; Alexander, Julie S.

    2007-01-01

    First-year seminars have increasingly been used as anchor courses in learning communities. This study investigated the impact participation in Freshman Seminar had on the grade earned in a linked learning community course in fall 2004. Grades in the linked course for 1,294 first-year students who were enrolled in 37 different learning communities…

  18. The Influence of Research within Religious Education: The Westhill Seminars, RE Professionals, Pupils and Schools

    ERIC Educational Resources Information Center

    Stern, Julian

    2014-01-01

    This article investigates the educational value of research studied by exploring the influence on a range of religious education professionals from a set of research seminars. The seminar series, sponsored by the Westhill Endowment Trust, has been running since 2004, bringing together teachers, advisors and higher education professionals working…

  19. Intellectual Curiosity in Action: A Framework to Assess First-Year Seminars in Liberal Arts Settings

    ERIC Educational Resources Information Center

    Kolb, Kenneth H.; Longest, Kyle C.; Barnett, Jenna C.

    2014-01-01

    Fostering students' intellectual curiosity is a common goal of first-year seminar programs--especially in liberal arts settings. The authors propose an alternative method to assess this ambiguous, value-laden concept. Relying on data gathered from pre- and posttest in-depth interviews of 34 students enrolled in first-year seminars, they…

  20. The Value of a First-Year Seminar: International Students' Insights in Retrospect

    ERIC Educational Resources Information Center

    Andrade, Maureen S.

    2009-01-01

    Higher education institutions in the United States commonly offer first-year seminars to assist students with their transition to college. Seminars are one of several types of first-year interventions based on findings from persistence research identifying variables affecting student success. Diverse student populations such as international…

  1. Use of Wikiversity and Role Play to Increase Student Engagement during Student-Led Physiology Seminars

    ERIC Educational Resources Information Center

    Singh, Satendra

    2013-01-01

    The Undergraduate Medical Program (Bachelor of Medicine and Bachelor of Surgery) at University College of Medical Sciences (Delhi, India) is a 4.5-yr, intense academic program where physiology is taught in the first year. To make the learning experience enriching, the Department of Physiology organizes four student seminars (two seminars/semester)…

  2. Educational Programming: A Seminar for Young Adults with Cleft Lip and/or Palate.

    ERIC Educational Resources Information Center

    Imhoff, Michael; And Others

    1981-01-01

    The social service staff of the H. K. Cooper Clinic (Lancaster, Pennsylvania) conducted a seminar for young adults with cleft lip and palate (CL/P) and their families. The seminar was designed to respond to questions and concerns regarding the impact of CL/P on employment, social relations, and genetics. (SB)

  3. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Accessibility of meetings, conferences, and seminars to persons with disabilities. 2452.222-70 Section 2452.222-70 Federal Acquisition... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  4. Fashioning Docile Teacher Bodies? The Strange Space of the "Staff Teaching Seminar"

    ERIC Educational Resources Information Center

    Grant, Barbara; Barrow, Mark

    2013-01-01

    For 40 years, the "staff teaching seminar" has aimed to prepare academics to meet the complex demands of university teaching. In Aotearoa/New Zealand (NZ), as elsewhere, the seminar emerged in the late 1960s-early 1970s, and preceded centrally funded academic development (AD) centres. Targeting new academics, the programme typically…

  5. EVALUATION CONFERENCE ON LEADERSHIP DEVELOPMENT SEMINARS, PROGRAM PLANNING, BUDGETING AND EVALUATION. FINAL REPORT.

    ERIC Educational Resources Information Center

    HIMMELE, IRVIN H.; SMITH, CLODUS R.

    THIRTY-FOUR PARTICIPANTS REPRESENTING THE LEADERSHIP-ACTION LEVEL OF PERSONNEL THROUGHOUT THE NATION AND FROM THE U.S. OFFICE OF EDUCATION EVALUATED THE LEADERSHIP DEVELOPMENT AND PROGRAM PLANNING, AND BUDGETING SEMINARS HELD DURING 1967. GUIDELINES FOR SEMINAR EVALUATION WERE PRESENTED--(1) "RATIONALE AND RETROSPECT" BY N. EDWIN CRAWFORD, (2)…

  6. A New Graduate-Level Seminar to Prepare Students for the Next Step in Their Careers

    ERIC Educational Resources Information Center

    Fleming, Kelly L.; Matthaei, James; Pfaendtner, Jim

    2015-01-01

    Many new Ph.D.s are not prepared for a competitive interview process in seeking a first job. The University of Washington (UW) designed the Distinguished Young Scholars Seminar (DYSS) to rectify this problem with three goals: simulate a visit associated with many interviews and a one-hour seminar; make UW graduate students aware of where they fit…

  7. Advocacy Seminar 2000 Course Book (Litchfield Park, Arizona, October 12-14, 2000).

    ERIC Educational Resources Information Center

    National School Boards Association, Alexandria, VA. Council of School Attorneys.

    This publication contains material from a 2-day seminar sponsored by the National School Boards Association's Council of School Attorneys. The notebook includes papers prepared by the seminar faculty, court documents, and other information related to the following topics: student threats; current issues of students with disabilities; the Family…

  8. Educational Technology; An AED/INNOTECH Seminar. (Singapore, April 10-13, 1972.)

    ERIC Educational Resources Information Center

    Southeast Asian Ministers of Education Organization (Singapore). Regional Center for Educational Innovation and Technology.

    The full texts of the five major papers presented at the Singapore seminar comprise the body of this conference report. The seminar was jointly sponsored by the Academy for Educational Development (AED) and the Southeast Asian Ministers of Education Organization's (SEAMEO) Regional Center for Educational Innovation and Technology (INNOTECH): its…

  9. Inservice Training Seminar for the Driver Licensing Administrative Hearing Officer. Instructor's Manual.

    ERIC Educational Resources Information Center

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    Intended for course instructors, this guide is the second of three designed for a two-day inservice training seminar for driver licensing administrative hearing officers. There are six sections, which acquaint the instructional staff with seminar duties, prescribe instructional methods, and cue instructors in visual aid use and unit time…

  10. Inservice Training Seminar for the Driver Licensing Administrative Hearing Officer. Administrator's Guide.

    ERIC Educational Resources Information Center

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    Intended for course administrators, this guide is the first of three designed for a two-day inservice training seminar for driver licensing administrative hearing officers. There are four sections. Following a brief introduction, the seminar agenda is provided. Day 1 focuses on six units: (1) an introduction, (2) the highway safety system, (3)…

  11. Inservice Training Seminar for the Driver Licensing Administrative Hearing Officer. Participant's Manual.

    ERIC Educational Resources Information Center

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    For use by trainees, this guide is the third of three designed for a two-day inservice training seminar for driver licensing administrative hearing officers. Participant's schedule information and materials are presented in three sections. The first includes the seminar agenda. Day 1 encompasses six units: (1) introduction, (2) the highway safety…

  12. Intensive Training Seminar for American Sign Language Interpreters, Post-Secondary Employment Emphasis.

    ERIC Educational Resources Information Center

    Eastfield Coll., Mesquite, TX.

    The intensive four-week seminar described in this report was designed for sign language interpreters currently employed or desiring employment in public post-secondary technical and vocational education. After explaining the objectives of the seminar, its targeted participants, and the training structure, the report presents an outline of the…

  13. An Analysis of Some of the Effects of "Schools Without Failure" Seminars on Participating Schools.

    ERIC Educational Resources Information Center

    Purl, Mabel C.; Dawson, Judith

    Written questionnaires were completed by the teachers, principals, and students of those elementary schools participating in the 1970-71 seminars based on William Glasser's concept of Schools Without Failure. The questionnaires were designed primarily to determine what changes had occurred since the seminars began and whether or not the schools…

  14. Do-It-Yourself Guide to: A Solid Waste Seminar. Construction Plans and Use Guidelines.

    ERIC Educational Resources Information Center

    Quarry Hill Nature Center, Rochester, Minn.

    Ten learning stations dealing with solid waste comprise the seminar described in this booklet. At each station, students observe a display and then answer questions listed on their data sheets. Although the seminar was intended for junior high school students, it has been used successfully with upper elementary and adult participants. Among the…

  15. Goodbye Lecture: A Student-Led Seminar Approach for Teaching Upper Division Courses

    ERIC Educational Resources Information Center

    Casteel, Mark A.; Bridges, K. Robert

    2007-01-01

    This article describes a seminar approach for teaching small classes of advanced undergraduates modeled on graduate seminar-style courses. Students act as daily discussion leaders for assigned readings, first in small teams and later individually, and the instructor acts as facilitator. Students received evaluations based on both their active…

  16. State Education & Environment Roundtable (SEER) Seminar (10th, Annapolis, Maryland, December 3-7, 2000).

    ERIC Educational Resources Information Center

    Lieberman, Gerald A.; Hoody, Linda L.

    This document reports on the 10th seminar of the State Education and Environment Roundtable (SEER). It consists of brief overviews of the daily discussions and presentations that were made at the seminar. Topics discussed include measuring success through student assessment, the Bay Schools Project (BSP), and a co-sponsored educational forum with…

  17. State Education & Environment Roundtable (SEER) Seminar (9th, San Diego, California, May 21-25, 2000).

    ERIC Educational Resources Information Center

    Lieberman, Gerald A.; Hoody, Linda L.

    This document reports on the 9th seminar of the State Education and Environment Roundtable (SEER). It consists of brief overviews of the daily discussions and presentations that were made at the seminar. Topics discussed include connecting service learning and the Environment as an Integrated Context for learning (EIC), and reports from states on…

  18. State Education & Environment Roundtable (SEER) Seminar (11th, Des Moines, Iowa, May 20-24, 2001).

    ERIC Educational Resources Information Center

    Lieberman, Gerald A.; Hoody, Linda L.

    This document reports on the 11th seminar of the State Education and Environment Roundtable (SEER). It consists of brief overviews of the daily discussions and presentations that were made at the seminar. Topics discussed include potential partnerships with national language arts organizations and associations, how environmental justice issues…

  19. Reinventing WAC (Again): The First-Year Seminar and Academic Literacy

    ERIC Educational Resources Information Center

    Brent, Doug

    2005-01-01

    Academically oriented first-year seminars can be good venues for teaching many of the concepts important to WAC programs, including extended engagement with a research topic and situated writing. A qualitative study of a first-year seminar program at the University of Calgary highlights faculty members' and students' responses.

  20. The "Other" Syllabus: Rendering Teaching Politics Visible in the Graduate Pedagogy Seminar

    ERIC Educational Resources Information Center

    Bailey, Lucy E.

    2010-01-01

    The author has explored the pedagogical possibilities of exploring doubt and ambiguity in graduate seminars in feminist pedagogy and teaching methods that she has been responsible for leading in several large public university settings. In these settings, faculty instituted the seminars in the graduate curriculum because they recognized the…

  1. Commentary: Margaret Mead, the Salzburg Seminar, and a Historical Evaluation Report.

    ERIC Educational Resources Information Center

    Greene, Jennifer C.

    2003-01-01

    Discusses Margaret Mead's evaluation of the first Salzburg Seminar (1947), a forum for international exchange of intellectual ideas and cultural customs. Concludes that Mead's evaluation was highly successful in that it created an evocative representation of the seminar that told readers what it was like for its participants. (SLD)

  2. Impact of a Sophomore Seminar on the Desire of STEM Majors to Pursue a Science Career

    ERIC Educational Resources Information Center

    Sweeder, Ryan D.; Strong, Philip E.

    2012-01-01

    This study focuses on the impact of a sophomore seminar on STEM majors desire to pursue a science career. This seminar was a component in a broader scholarship program and focused on helping students gain a broader understanding of the process of science, expose students to a range of career options and provide opportunities for outside of class…

  3. Guido Beck, Alexandre Proca, and the Oporto Theoretical Physics Seminar

    NASA Astrophysics Data System (ADS)

    Dos Santos Fitas, Augusto José; Passos Videira, António Augusto

    2007-01-01

    We describe the pioneering attempts made by Ruy Luís Gomes (1905 1984) and other Portuguese physicists to develop a research and teaching seminar in theoretical physics at the University of Oporto in 1942 1944 under the leadership first of the refugee Austrian theoretical physicist Guido Beck (1903 1988) and then of the Romanian-French theoretical physicist Alexandre Proca (1896 1955). These efforts failed, however, owing to lack of sustained financial support from the Portuguese government and to the political repression of the Salazar regime, which dismissed Gomes and other prominent Portuguese physicists and other scientists from their university positions.

  4. Seminar in Critical Inquiry Twenty-first Century Nuclear Systems

    SciTech Connect

    LeMone, D. V.

    2002-02-25

    Critical Inquiry, has not only been successful in increasing university student retention rate but also in improving student academic performance beyond the initial year of transition into the University. The seminar course herein reviewed is a balanced combination of student personal and academic skill development combined with a solid background in modern nuclear systems. It is a valid premise to assume that entering students as well as stakeholders of the general public demonstrate equal levels of capability. Nuclear systems is designed to give a broad and basic knowledge of nuclear power, medical, industrial, research, and military systems (nuclear systems) in 20-25 hours.

  5. 2007 Plant Metabolic Engineering Gordon Conference and Graduate Research Seminar

    SciTech Connect

    Erich Grotewold

    2008-09-15

    Plant Metabolic Engineering is an emerging field that integrates a diverse range of disciplines including plant genetics, genomics, biochemistry, chemistry and cell biology. The Gordon-Kenan Graduate Research Seminar (GRS) in Plant Metabolic Engineering was initiated to provide a unique opportunity for future researcher leaders to present their work in this field. It also creates an environment allowing for peer-review and critical assessment of work without the intimidation usually associated with the presence of senior investigators. The GRS immediately precedes the Plant Metabolic Engineering Gordon Research Conference and will be for and by graduate students and post-docs, with the assistance of the organizers listed.

  6. Supportive seminar groups: an intervention for early stage dementia patients.

    PubMed

    Snyder, L; Quayhagen, M P; Shepherd, S; Bower, D

    1995-10-01

    A supportive seminar group was developed and conducted for individuals with early stage dementia and their caregivers. The eight sessions focused on pertinent topics, namely, coping with memory problems, daily living, self-esteem, relationships, health, legal, and financial concerns. Content analysis of the evaluative statements from nine men and six women patients revealed positive themes of feelings of purposefulness, gratification, belongingness, and survival, while other themes reflected the turmoil of the disease, namely, feelings of helplessness, devaluation, and unpredictability. These preliminary findings lend support to the feasibility of a group approach for early stage dementia patients.

  7. The Impact of First-Year Seminars on College Students' Life-Long Learning Orientations

    ERIC Educational Resources Information Center

    Padgett, Ryan D.; Keup, Jennifer R.; Pascarella, Ernest T.

    2013-01-01

    Using longitudinal data from the Wabash National Study of Liberal Arts Education, this study measured the impact of first-year seminars on college students' life-long learning orientations. The findings suggest that first-year seminars enhance students' life-long learning orientations and that the effect of first-year seminars is…

  8. Literature Seminars for Gifted and Talented Students: Creating Exciting Units for Students to Go beyond the Usual Course of Study.

    ERIC Educational Resources Information Center

    Dixon, Felicia

    1994-01-01

    This article describes the structure and operation of three literature seminars offered in the English curriculum at the Indiana Academy for Science, Mathematics, and Humanities. The seminar approach puts the responsibility on the student and fosters creativity, thinking skills, and problem solving. The seminars include: "Dickens,""Russian…

  9. The 1993 Finnish Interdisciplinary Seminar on SETI - A review of aims, approaches and conclusions

    NASA Astrophysics Data System (ADS)

    Seppanen, Jouko

    1993-10-01

    The communications of the International Interdisciplinary Seminar on SETI, held on March 6-7, 1993 in Vantaa, Finland, are reviewed and the contents and conclusions of papers summarized. The seminar was organized jointly by the Finnish Artificial Intelligence Society (FAIS), Finnish Astronomical Society, Ursa Astronomical Association and Heureka - The Finnish Science Centre. As the ninth in a series of intelligence-related seminars of FAIS, SETI was chosen as the topic for spring 1993, noting the new ten year NASA SETI program HRMS (High Resolution Micro-wave Survey), commenced on Columbus Day, October 12, 1992. The aims and the interdisciplinary format of the seminar are described, the main results and conclusions of papers are restated, and the seminar publications introduced. The summaries of papers are based on their abstracts and contain excerpts from texts.

  10. Teamwork Seminar Practice to Foster Diversified Thinking and Leadership Among Students

    NASA Astrophysics Data System (ADS)

    Maruyama, Naoki; Yoshida, Kazumi; Yamao, Hidenori

    A new course entitled “Mechanical Engineering Seminar” has begun in the Department of Mechanical Engineering, Mie University. This course consists of three parts, a teamwork seminar, a creative design seminar and a comprehensive achievement examination. Its aim is to foster a broad social and international outlook, ethical thinking, autonomy, partnership, leadership, presentation ability, originality, overall creativity in students, and to help them become aware of their real ability. The teaching method used in this seminar is based on problem-based learning (PBL) , and pro-active student participation is required. The purpose of this paper is to report the features, teaching method and educational effectiveness of the teamwork seminar, which seeks to educate students with a broad, diversified outlook. The results of a student questionnaire show that these new fields of study stimulate students' will to learn, and they express general satisfaction with the seminar.

  11. Guiding the folding pathway of DNA origami

    NASA Astrophysics Data System (ADS)

    Dunn, Katherine E.; Dannenberg, Frits; Ouldridge, Thomas E.; Kwiatkowska, Marta; Turberfield, Andrew J.; Bath, Jonathan

    2015-09-01

    DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short `staple' strands. Its guiding design principle is that the target structure is the single most stable configuration. The folding transition is cooperative and, as in the case of proteins, is governed by information encoded in the polymer sequence. A typical origami folds primarily into the desired shape, but misfolded structures can kinetically trap the system and reduce the yield. Although adjusting assembly conditions or following empirical design rules can improve yield, well-folded origami often need to be separated from misfolded structures. The problem could in principle be avoided if assembly pathway and kinetics were fully understood and then rationally optimized. To this end, here we present a DNA origami system with the unusual property of being able to form a small set of distinguishable and well-folded shapes that represent discrete and approximately degenerate energy minima in a vast folding landscape, thus allowing us to probe the assembly process. The obtained high yield of well-folded origami structures confirms the existence of efficient folding pathways, while the shape distribution provides information about individual trajectories through the folding landscape. We find that, similarly to protein folding, the assembly of DNA origami is highly cooperative; that reversible bond formation is important in recovering from transient misfoldings; and that the early formation of long-range connections can very effectively enforce particular folds. We use these insights to inform the design of the system so as to steer assembly towards desired structures. Expanding the rational design process to include the assembly pathway should thus enable more reproducible synthesis, particularly when targeting more complex structures. We anticipate that this expansion will be essential if DNA origami is to continue its

  12. Retinal and Choroidal Folds in Papilledema

    PubMed Central

    Sibony, Patrick A.; Kupersmith, Mark J.; Feldon, Steven E.; Wang, Jui-Kai; Garvin, Mona

    2015-01-01

    Purpose To determine the frequency, patterns, associations, and biomechanical implications of retinal and choroidal folds in papilledema due to idiopathic intracranial hypertension (IIH). Methods Retinal and choroidal folds were studied in patients enrolled in the IIH Treatment Trial using fundus photography (n = 165 study eyes) and spectral-domain optical coherence tomography (SD-OCT; n = 125). We examined the association between folds and peripapillary shape, retinal nerve fiber layer (RNFL) thickness, disc volume, Frisén grade, acuity, perimetric mean deviation, intraocular pressure, intracranial pressure, and refractive error. Results We identified three types of folds in IIH patients with papilledema: peripapillary wrinkles (PPW), retinal folds (RF), and choroidal folds (CF). Frequency, with photos, was 26%, 19%, and 1%, respectively; SD-OCT frequency was 46%, 47%, and 10%. At least one type of fold was present in 41% of patients with photos and 73% with SD-OCT. Spectral-domain OCT was more sensitive. Structural parameters related to the severity of papilledema were associated with PPW and RF, whereas anterior deformation of the peripapillary RPE/basement membrane layer was associated with CF and RF. Folds were not associated with vision loss at baseline. Conclusions Folds in papilledema are biomechanical signs of stress/strain on the optic nerve head and load-bearing structures induced by intracranial hypertension. Folds are best imaged with SD-OCT. The patterns of retinal and choroidal folds are the products of a complex interplay between the degree of papilledema and anterior deformation of the load-bearing structures (sclera and possibly the lamina cribrosa), both modulated by structural geometry and material properties of the optic nerve head. (ClinicalTrials.gov number, NCT01003639.) PMID:26335066

  13. Effectiveness of modified seminars as a teaching-learning method in pharmacology

    PubMed Central

    Palappallil, Dhanya Sasidharan; Sushama, Jitha; Ramnath, Sai Nathan

    2016-01-01

    Context: Student-led seminars (SLS) are adopted as a teaching-learning (T-L) method in pharmacology. Previous studies assessing the feedback on T-L methods in pharmacology points out that the traditional seminars consistently received poor feedbacks as they were not favorite among the students. Aims: This study aimed to obtain feedback on traditional SLS, introduce modified SLS and compare the modified seminars with the traditional ones. Settings and Design: This was a prospective interventional study done for 2 months in medical undergraduates of fifth semester attending Pharmacology seminars at a Government Medical College in South India. Subjects and Methods: Structured questionnaire was used to elicit feedback from participants. The responses were coded on 5-point Likert scale. Modifications in seminar sessions such as role plays, quiz, tests, group discussion, and patient-oriented problem-solving exercises were introduced along with SLS. Statistical Analysis Used: The data were analyzed using SPSS version 16. The descriptive data were expressed using frequencies and percentages. Wilcoxon signed rank test, and Friedman tests were used to compare traditional with modified seminars. Results: The participants identified interaction as the most important component of a seminar. Majority opined that the teacher should summarize at the end of SLS. Student feedback shows that modified seminars created more interest, enthusiasm, and inspiration to learn the topic when compared to traditional SLS. They also increased peer coordination and group dynamics. Students opined that communication skills and teacher-student interactions were not improved with modified seminars. Conclusions: Interventions in the form of modified SLS may be adopted to break the monotony of traditional seminars through active participation, peer interaction, and teamwork. PMID:27563587

  14. Simultaneous Alignment and Folding of Protein Sequences

    PubMed Central

    Waldispühl, Jérôme; O'Donnell, Charles W.; Will, Sebastian; Devadas, Srinivas; Backofen, Rolf

    2014-01-01

    Abstract Accurate comparative analysis tools for low-homology proteins remains a difficult challenge in computational biology, especially sequence alignment and consensus folding problems. We present partiFold-Align, the first algorithm for simultaneous alignment and consensus folding of unaligned protein sequences; the algorithm's complexity is polynomial in time and space. Algorithmically, partiFold-Align exploits sparsity in the set of super-secondary structure pairings and alignment candidates to achieve an effectively cubic running time for simultaneous pairwise alignment and folding. We demonstrate the efficacy of these techniques on transmembrane β-barrel proteins, an important yet difficult class of proteins with few known three-dimensional structures. Testing against structurally derived sequence alignments, partiFold-Align significantly outperforms state-of-the-art pairwise and multiple sequence alignment tools in the most difficult low-sequence homology case. It also improves secondary structure prediction where current approaches fail. Importantly, partiFold-Align requires no prior training. These general techniques are widely applicable to many more protein families (partiFold-Align is available at http://partifold.csail.mit.edu/). PMID:24766258

  15. Local vs global motions in protein folding

    PubMed Central

    Maisuradze, Gia G.; Liwo, Adam; Senet, Patrick; Scheraga, Harold A.

    2013-01-01

    It is of interest to know whether local fluctuations in a polypeptide chain play any role in the mechanism by which the chain folds to the native structure of a protein. This question is addressed by analyzing folding and non-folding trajectories of a protein; as an example, the analysis is applied to the 37-residue triple β-strand WW domain from the Formin binding protein 28 (FBP28) (PDB ID: 1E0L). Molecular dynamics (MD) trajectories were generated with the coarse-grained united-residue force field, and one- and two-dimensional free-energy landscapes (FELs) along the backbone virtual-bond angle θ and backbone virtual-bond-dihedral angle γ of each residue, and principal components, respectively, were analyzed. The key residues involved in the folding of the FBP28 WW domain are elucidated by this analysis. The correlations between local and global motions are found. It is shown that most of the residues in the folding trajectories of the system studied here move in a concerted fashion, following the dynamics of the whole system. This demonstrates how the choice of a pathway has to involve concerted movements in order for this protein to fold. This finding also sheds light on the effectiveness of principal component analysis (PCA) for the description of the folding dynamics of the system studied. It is demonstrated that the FEL along the PCs, computed by considering only several critically-placed residues, can correctly describe the folding dynamics. PMID:23914144

  16. Protein folding: When ribosomes pick the structure

    NASA Astrophysics Data System (ADS)

    Sivertsson, Elin M.; Itzhaki, Laura S.

    2014-05-01

    Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.

  17. Folding Polyominoes from One Level to Two

    ERIC Educational Resources Information Center

    Frederickson, Greg N.

    2011-01-01

    For any given polyomino, is it possible to cut it into pieces and then hinge the pieces, so that the polyomino folds up into a similar version of itself but two levels thick? While we don't know how to do this for every polyomino, the article does show how to cut, hinge, and fold polyominoes from several infinite classes, providing an…

  18. Similarities between protein folding and granular jamming

    PubMed Central

    Jose, Prasanth P; Andricioaei, Ioan

    2012-01-01

    Grains and glasses, widely different materials, arrest their motions upon decreasing temperature and external load, respectively, in common ways, leading to a universal jamming phase diagram conjecture. However, unified theories are lacking, mainly because of the disparate nature of the particle interactions. Here we demonstrate that folded proteins exhibit signatures common to both glassiness and jamming by using temperature- and force-unfolding molecular dynamics simulations. Upon folding, proteins develop a peak in the interatomic force distributions that falls on a universal curve with experimentally measured forces on jammed grains and droplets. Dynamical signatures are found as a dramatic slowdown of stress relaxation upon folding. Together with granular similarities, folding is tied not just to the jamming transition, but a more nuanced picture of anisotropy, preparation protocol and internal interactions emerges. Results have implications for designing stable polymers and can open avenues to link protein folding to jamming theory. PMID:23093180

  19. Geometry and wetting of capillary folding.

    PubMed

    Péraud, Jean-Philippe; Lauga, Eric

    2014-04-01

    Capillary forces are involved in a variety of natural phenomena, ranging from droplet breakup to the physics of clouds. The forces from surface tension can also be exploited in industrial applications provided the length scales involved are small enough. Recent experimental investigations showed how to take advantage of capillarity to fold planar structures into three-dimensional configurations by selectively melting polymeric hinges joining otherwise rigid shapes. In this paper we use theoretical calculations to quantify the role of geometry and fluid wetting on the final folded state. Considering folding in two and three dimensions, studying both hydrophilic and hydrophobic situations with possible contact-angle hysteresis, and addressing the shapes to be folded to be successively infinite, finite, curved, kinked, and elastic, we are able to derive an overview of the geometrical parameter space available for capillary folding.

  20. Prediction of sound from human vocal folds

    NASA Astrophysics Data System (ADS)

    Bodony, Daniel; Luo, Haoxiang; Mittal, Rajat

    2007-11-01

    The creation of voiced sounds in humans depends on the flow-induced vibration of the vocal folds within the larynx. The vocal folds, which are a complex structural system of cartilage and tissue, create an oscillatory ``glottal jet'' whose harmonic content partially determines the tone of the speech. In this work we will discuss the process of sound generation in the laynx by combining a fully coupled two-dimensional fluid-structure simulation of the incompressible flow field in the vicinity of the vocal folds to an acoustic analogy description of the sound field. The structural dynamics of the vocal folds are based on physically realistic properties and are coupled to the motion of the fluid via an immersed boundary method. Relationships between the sound produced and the vocal fold dynamics will be discussed.

  1. Visualizing chaperone-assisted protein folding.

    PubMed

    Horowitz, Scott; Salmon, Loïc; Koldewey, Philipp; Ahlstrom, Logan S; Martin, Raoul; Quan, Shu; Afonine, Pavel V; van den Bedem, Henry; Wang, Lili; Xu, Qingping; Trievel, Raymond C; Brooks, Charles L; Bardwell, James C A

    2016-07-01

    Challenges in determining the structures of heterogeneous and dynamic protein complexes have greatly hampered past efforts to obtain a mechanistic understanding of many important biological processes. One such process is chaperone-assisted protein folding. Obtaining structural ensembles of chaperone-substrate complexes would ultimately reveal how chaperones help proteins fold into their native state. To address this problem, we devised a new structural biology approach based on X-ray crystallography, termed residual electron and anomalous density (READ). READ enabled us to visualize even sparsely populated conformations of the substrate protein immunity protein 7 (Im7) in complex with the Escherichia coli chaperone Spy, and to capture a series of snapshots depicting the various folding states of Im7 bound to Spy. The ensemble shows that Spy-associated Im7 samples conformations ranging from unfolded to partially folded to native-like states and reveals how a substrate can explore its folding landscape while being bound to a chaperone. PMID:27239796

  2. Fan-fold shielded electrical leads

    DOEpatents

    Rohatgi, Rajeev R.; Cowan, Thomas E.

    1996-01-01

    Fan-folded electrical leads made from copper cladded Kapton, for example, with the copper cladding on one side serving as a ground plane and the copper cladding on the other side being etched to form the leads. The Kapton is fan folded with the leads located at the bottom of the fan-folds. Electrical connections are made by partially opening the folds of the fan and soldering, for example, the connections directly to the ground plane and/or the lead. The fan folded arrangement produces a number of advantages, such as electrically shielding the leads from the environment, is totally non-magnetic, and has a very low thermal conductivity, while being easy to fabricate.

  3. Fan-fold shielded electrical leads

    DOEpatents

    Rohatgi, R.R.; Cowan, T.E.

    1996-06-11

    Disclosed are fan-folded electrical leads made from copper cladded Kapton, for example, with the copper cladding on one side serving as a ground plane and the copper cladding on the other side being etched to form the leads. The Kapton is fan folded with the leads located at the bottom of the fan-folds. Electrical connections are made by partially opening the folds of the fan and soldering, for example, the connections directly to the ground plane and/or the lead. The fan folded arrangement produces a number of advantages, such as electrically shielding the leads from the environment, is totally non-magnetic, and has a very low thermal conductivity, while being easy to fabricate. 3 figs.

  4. Folding and Finding RNA Secondary Structure

    PubMed Central

    Mathews, David H.; Moss, Walter N.; Turner, Douglas H.

    2010-01-01

    SUMMARY Optimal exploitation of the expanding database of sequences requires rapid finding and folding of RNAs. Methods are reviewed that automate folding and discovery of RNAs with algorithms that couple thermodynamics with chemical mapping, NMR, and/or sequence comparison. New functional noncoding RNAs in genome sequences can be found by combining sequence comparison with the assumption that functional noncoding RNAs will have more favorable folding free energies than other RNAs. When a new RNA is discovered, experiments and sequence comparison can restrict folding space so that secondary structure can be rapidly determined with the help of predicted free energies. In turn, secondary structure restricts folding in three dimensions, which allows modeling of three-dimensional structure. An example from a domain of a retrotransposon is described. Discovery of new RNAs and their structures will provide insights into evolution, biology, and design of therapeutics. Applications to studies of evolution are also reviewed. PMID:20685845

  5. The robustness and innovability of protein folds.

    PubMed

    Tóth-Petróczy, Agnes; Tawfik, Dan S

    2014-06-01

    Assignment of protein folds to functions indicates that >60% of folds carry out one or two enzymatic functions, while few folds, for example, the TIM-barrel and Rossmann folds, exhibit hundreds. Are there structural features that make a fold amenable to functional innovation (innovability)? Do these features relate to robustness--the ability to readily accumulate sequence changes? We discuss several hypotheses regarding the relationship between the architecture of a protein and its evolutionary potential. We describe how, in a seemingly paradoxical manner, opposite properties, such as high stability and rigidity versus conformational plasticity and structural order versus disorder, promote robustness and/or innovability. We hypothesize that polarity--differentiation and low connectivity between a protein's scaffold and its active-site--is a key prerequisite for innovability.

  6. The Promise of Literacy. Campaigns, Programs and Projects. Report of the International Seminar on Campaigning for Literacy (Udaipur, India, January 4-11, 1982).

    ERIC Educational Resources Information Center

    Bhola, H. S.; And Others

    This report on the International Seminar on Campaigning for Literacy at Udaipur, India is divided into three main parts. Part 1 describes the context and background of the seminar, its specific objectives, and the organization and procedures of the seminar. Part 2 provides an overview of the seminar proceedings. The inaugural statements are…

  7. Dynamics of an Ultrafast Folding Subdomain in the Context of a Larger Protein Fold

    PubMed Central

    Davis, Caitlin M.; Dyer, R. Brian

    2014-01-01

    Small fast folding subdomains with low contact order have been postulated to facilitate the folding of larger proteins. We have tested this idea by determining how the fastest folding linear β-hairpin, CLN025, which folds on the nanosecond time scale, folds within the context of a two-hairpin WW domain system, which folds on the microsecond time scale. The folding of the wild type FBP28 WW domain was compared to constructs in which each of the loops was replaced by CLN025. A combination of FTIR spectroscopy and laser-induced temperature-jump coupled with infrared spectroscopy was used to probe changes in the peptide backbone. The relaxation dynamics of the β-sheets and β-turn were measured independently by probing the corresponding bands assigned in the amide I region. The folding rate of the CLN025 β-hairpin is unchanged within the larger protein. Insertion of the β-hairpin into the second loop results in an overall stabilization of the WW domain and a relaxation lifetime five times faster than the parent WW domain. In both mutants, folding is initiated in the turns and the β-sheets form last. These results demonstrate that fast folding subdomains can be used to speed the folding of more complex proteins, and that the folding dynamics of the subdomain is unchanged within the context of the larger protein. PMID:24320936

  8. Effects of Folding on Metalloprotein Active Sites

    NASA Astrophysics Data System (ADS)

    Winkler, Jay R.; Wittung-Stafshede, Pernilla; Leckner, Johan; Malmstrom, Bo G.; Gray, Harry B.

    1997-04-01

    Experimental data for the unfolding of cytochrome c and azurin by guanidinium chloride (GuHCl) are used to construct free-energy diagrams for the folding of the oxidized and reduced proteins. With cytochrome c, the driving force for folding the reduced protein is larger than that for the oxidized form. Both the oxidized and the reduced folded forms of yeast cytochrome c are less stable than the corresponding states of the horse protein. Due to the covalent attachment of the heme and its fixed tetragonal coordination geometry, cytochrome c folding can be described by a two-state model. A thermodynamic cycle leads to an expression for the difference in self-exchange reorganization energies for the folded and unfolded proteins. The reorganization energy for electron exchange in the folded protein is approximately 0.5 eV smaller than that for a heme in aqueous solution. The finding that reduced azurin unfolds at lower GuHCl concentrations than the oxidized protein suggests that the coordination structure of copper is different in oxidized and reduced unfolded states: it is likely that the geometry of CuI in the unfolded protein is linear or trigonal, whereas CuII prefers to be tetragonal. The evidence indicates that protein folding lowers the azurin reorganization energy by roughly 1.7 eV relative to an aqueous Cu(1,10-phenanthroline)2{}2+/+ reference system.

  9. Quantification of a Helical Origami Fold

    NASA Astrophysics Data System (ADS)

    Dai, Eric; Han, Xiaomin; Chen, Zi

    2015-03-01

    Origami, the Japanese art of paper folding, is traditionally viewed as an amusing pastime and medium of artistic expression. However, in recent years, origami has served as a source of inspiration for innovations in science and engineering. Here, we present the geometric and mechanical properties of a twisting origami fold. The origami structure created by the fold exhibits several interesting properties, including rigid foldibility, local bistability and finely tunable helical coiling, with control over pitch, radius and handedness of the helix. In addition, the pattern generated by the fold closely mimics the twist buckling patterns shown by thin materials, for example, a mobius strip. We use six parameters of the twisting origami pattern to generate a fully tunable graphical model of the fold. Finally, we present a mathematical model of the local bistability of the twisting origami fold. Our study elucidates the mechanisms behind the helical coiling and local bistability of the twisting origami fold, with potential applications in robotics and deployable structures. Acknowledgment to Branco Weiss Fellowship for funding.

  10. Folding pathways of the Tetrahymena ribozyme.

    PubMed

    Mitchell, David; Russell, Rick

    2014-06-12

    Like many structured RNAs, the Tetrahymena group I intron ribozyme folds through multiple pathways and intermediates. Under standard conditions in vitro, a small fraction reaches the native state (N) with kobs ≈ 0.6 min(-1), while the remainder forms a long-lived misfolded conformation (M) thought to differ in topology. These alternative outcomes reflect a pathway that branches late in folding, after disruption of a trapped intermediate (Itrap). Here we use catalytic activity to probe the folding transitions from Itrap to the native and misfolded states. We show that mutations predicted to weaken the core helix P3 do not increase the rate of folding from Itrap but they increase the fraction that reaches the native state rather than forming the misfolded state. Thus, P3 is disrupted during folding to the native state but not to the misfolded state, and P3 disruption occurs after the rate-limiting step. Interestingly, P3-strengthening mutants also increase native folding. Additional experiments show that these mutants are rapidly committed to folding to the native state, although they reach the native state with approximately the same rate constant as the wild-type ribozyme (~1 min(-1)). Thus, the P3-strengthening mutants populate a distinct pathway that includes at least one intermediate but avoids the M state, most likely because P3 and the correct topology are formed early. Our results highlight multiple pathways in RNA folding and illustrate how kinetic competitions between rapid events can have long-lasting effects because the "choice" is enforced by energy barriers that grow larger as folding progresses.

  11. Folding pathways of the Tetrahymena ribozyme

    PubMed Central

    Mitchell, David; Russell, Rick

    2014-01-01

    Like many structured RNAs, the Tetrahymena group I intron ribozyme folds through multiple pathways and intermediates. Under standard conditions in vitro, a small fraction reaches the native state (N) with kobs ≈ 0.6 min–1, while the remainder forms a long-lived misfolded conformation (M) thought to differ in topology. These alternative outcomes reflect a pathway that branches late in folding, after disruption of a trapped intermediate (Itrap). Here, we use catalytic activity to probe the folding transitions from Itrap to the native and misfolded states. We show that mutations predicted to weaken the core helix P3 do not increase the rate of folding from Itrap but they increase the fraction that reaches the native state rather than forming the misfolded state. Thus, P3 is disrupted during folding to the native state but not to the misfolded state, and P3 disruption occurs after the rate-limiting step. Interestingly, P3-strengthening mutants also increase native folding. Additional experiments show that these mutants are rapidly committed to folding to the native state, although they reach the native state with approximately the same rate constant as the wild-type ribozyme (~1 min–1). Thus, the P3-strengthening mutants populate a distinct pathway that includes at least one intermediate but avoids the M state, most likely because P3 and the correct topology are formed early. Our results highlight multiple pathways in RNA folding and illustrate how kinetic competitions between rapid events can have long-lasting effects because the ‘choice’ is enforced by energy barriers that grow larger as folding progresses. PMID:24747051

  12. Network measures for protein folding state discrimination

    PubMed Central

    Menichetti, Giulia; Fariselli, Piero; Remondini, Daniel

    2016-01-01

    Proteins fold using a two-state or multi-state kinetic mechanisms, but up to now there is not a first-principle model to explain this different behavior. We exploit the network properties of protein structures by introducing novel observables to address the problem of classifying the different types of folding kinetics. These observables display a plain physical meaning, in terms of vibrational modes, possible configurations compatible with the native protein structure, and folding cooperativity. The relevance of these observables is supported by a classification performance up to 90%, even with simple classifiers such as discriminant analysis. PMID:27464796

  13. Osteochondrodysplasia in three Scottish Fold cats.

    PubMed

    Chang, Jinhwa; Jung, Joohyun; Oh, Sunkyoung; Lee, Sungok; Kim, Gyeongmin; Kim, Haksang; Kweon, Ohkyeong; Yoon, Junghee; Choi, Mincheol

    2007-09-01

    This report explains typical radiographic features of Scottish Fold osteochondrodysplasia. Three Scottish Fold cats suffering from lameness were referred to the Veterinary Medical Teaching Hospital, Seoul National University, Korea. Based on the breed predisposition, history, clinical signs, physical examination, and radiographic findings, Scottish Fold osteochondrodysplasia was confirmed in three cases. Radiographic changes mainly included exostosis and secondary arthritis around affected joint lesions, and defective conformation in the phalanges and caudal vertebrae. The oral chondroprotective agents such as glucosamine and chondroitin sulfate make the patients alleviate their pain without adverse effects. PMID:17679781

  14. Mechanical Models of Fault-Related Folding

    SciTech Connect

    Johnson, A. M.

    2003-01-09

    The subject of the proposed research is fault-related folding and ground deformation. The results are relevant to oil-producing structures throughout the world, to understanding of damage that has been observed along and near earthquake ruptures, and to earthquake-producing structures in California and other tectonically-active areas. The objectives of the proposed research were to provide both a unified, mechanical infrastructure for studies of fault-related foldings and to present the results in computer programs that have graphical users interfaces (GUIs) so that structural geologists and geophysicists can model a wide variety of fault-related folds (FaRFs).

  15. Network measures for protein folding state discrimination.

    PubMed

    Menichetti, Giulia; Fariselli, Piero; Remondini, Daniel

    2016-01-01

    Proteins fold using a two-state or multi-state kinetic mechanisms, but up to now there is not a first-principle model to explain this different behavior. We exploit the network properties of protein structures by introducing novel observables to address the problem of classifying the different types of folding kinetics. These observables display a plain physical meaning, in terms of vibrational modes, possible configurations compatible with the native protein structure, and folding cooperativity. The relevance of these observables is supported by a classification performance up to 90%, even with simple classifiers such as discriminant analysis. PMID:27464796

  16. Highlights from the 52nd Seminar of the Korean Society of Gastrointestinal Endoscopy

    PubMed Central

    Kim, Eun Young; Choi, Il Ju; Kwon, Kwang An; Ryu, Ji Kon

    2015-01-01

    In this July issue of Clinical Endoscopy, state-of-the-art articles selected from the lectures delivered during the 52nd Seminar of the Korean Society of Gastrointestinal Endoscopy (KSGE) on March 29, 2015 are covered, focusing on highlighted educational contents relevant to either diagnostic or therapeutic gastrointestinal (GI) endoscopy. Our society, the KSGE, has continued to host this opportunity for annual seminars twice a year over the last 26 years and it has become a large-scale prestigious seminar accommodating over 4,000 participants. Definitely, the KSGE seminar is considered as one of the premier state-of-the-art seminars dealing with GI endoscopy, appealing to both the beginner and advanced experts. Lectures, live demonstrations, hands-on courses, as well as an editor school, which was an important consensus meeting on how to upgrade our society journal, Clinical Endoscopy, to a Science Citation Index (Expanded) designation were included in this seminar. The 52nd KSGE seminar consisted of more than 20 sessions, including special lectures, concurrent sessions for GI endoscopy nurses, and sessions exploring new technologies. This is a very special omnibus article to highlight the core contents divided into four sessions: upper GI tract, lower GI tract, pancreatobiliary system, and other specialized sessions. PMID:26240798

  17. Evaluation of hands-on seminar for reduced port surgery using fresh porcine cadaver model

    PubMed Central

    Poudel, Saseem; Kurashima, Yo; Shichinohe, Toshiaki; Kitashiro, Shuji; Kanehira, Eiji; Hirano, Satoshi

    2016-01-01

    BACKGROUND: The use of various biological and non-biological simulators is playing an important role in training modern surgeons with laparoscopic skills. However, there have been few reports of the use of a fresh porcine cadaver model for training in laparoscopic surgical skills. The purpose of this study was to report on a surgical training seminar on reduced port surgery using a fresh cadaver porcine model and to assess its feasibility and efficacy. MATERIALS AND METHODS: The hands-on seminar had 10 fresh porcine cadaver models and two dry boxes. Each table was provided with a unique access port and devices used in reduced port surgery. Each group of 2 surgeons spent 30 min at each station, performing different tasks assisted by the instructor. The questionnaire survey was done immediately after the seminar and 8 months after the seminar. RESULTS: All the tasks were completed as planned. Both instructors and participants were highly satisfied with the seminar. There was a concern about the time allocated for the seminar. In the post-seminar survey, the participants felt that the number of reduced port surgeries performed by them had increased. CONCLUSION: The fresh cadaver porcine model requires no special animal facility and can be used for training in laparoscopic procedures. PMID:27279391

  18. Synergistic relationship between the Columbia University Appetitive Behavior Seminar and the satiating effect of cholecystokinin.

    PubMed

    Smith, Gerard P

    2013-12-01

    Synergism between the Columbia University Appetitive Behavior Seminar and the research program of Smith and Gibbs on the satiating effect of cholecystokinin during the past 40 years is described. The Seminar was synergistic with the research program in five ways. First, the steady parade of speakers gave us a window on the varied and interesting work going on in the field. Second, the Seminar was the kind of audience for presentations of the work-in-progress on CCK that scientists hope for and rarely find. Criticism by members of the Seminar was relentless and constructive, and ideas for further experiments or new ways to tackle problematic data poured forth. Third, members of the Seminar did experiments that facilitated the experimental success of the research program. Fourth, members of the Seminar tutored us on topics that we wanted to import into the research program on CCK. Fifth, and probably most important, members of the Seminar gave us the encouragement, good humor, and friendship so necessary for coping with the struggles of the scientific life.

  19. Under-folded proteins: Conformational ensembles and their roles in protein folding, function, and pathogenesis.

    PubMed

    Uversky, Vladimir N

    2013-11-01

    For decades, protein function was intimately linked to the presence of a unique, aperiodic crystal-like structure in a functional protein. The two only places for conformational ensembles of under-folded (or partially folded) protein forms in this picture were either the end points of the protein denaturation processes or transiently populated folding intermediates. Recent years witnessed dramatic change in this perception and conformational ensembles, which the under-folded proteins are, have moved from the shadow. Accumulated to date data suggest that a protein can exist in at least three global forms-functional and folded, functional and intrinsically disordered (nonfolded), and nonfunctional and misfolded/aggregated. Under-folded protein states are crucial for each of these forms, serving as important folding intermediates of ordered proteins, or as functional states of intrinsically disordered proteins (IDPs) and IDP regions (IDPRs), or as pathology triggers of misfolded proteins. Based on these observations, conformational ensembles of under-folded proteins can be classified as transient (folding and misfolding intermediates) and permanent (IDPs and stable misfolded proteins). Permanently under-folded proteins can further be split into intentionally designed (IDPs and IDPRs) and unintentionally designed (misfolded proteins). Although intrinsic flexibility, dynamics, and pliability are crucial for all under-folded proteins, the different categories of under-foldedness are differently encoded in protein amino acid sequences.

  20. Dew-driven folding of insect wings

    NASA Astrophysics Data System (ADS)

    Dickerson, Andrew; Beadles, Sam; Clement, Courtney; Hu, David

    2013-11-01

    Small insect wings fold into tacos when exposed to dewfall or fog for extended times. Such shapes are tightly held together and require great force or long evaporation times for the wings to unfold. In this experimental investigation, we use time-lapse and high-speed videography on a mosquito wing exposed to fog to characterize the folding process from a flat wing to a taco. We observe a taco is formed through a series of processes involving wing bending, unbending, and subsequent tight folding of the wing following the sliding of the drop off the wing. We use a simplified 2D model to determine the forces coalescing drops exert on the wing, and present folding-resistant design suggestions for micro-aerial vehicle wings.

  1. Folded waveguide coupler for ion cyclotron heating

    SciTech Connect

    Owens, T.L.; Chen, G.L.

    1986-01-01

    A new type of waveguide coupler for plasma heating in the ion cyclotron range of frequencies is described. The coupler consists of a series of interleaved metallic vanes within a rectangular enclosure analogous to a wide rectangular waveguide that has been ''folded'' several times. At the mouth of the coupler, a plate is attached which contains coupling apertures in each fold or every other fold of the waveguide, depending upon the wavenumber spectrum desired. This plate serves primarily as a wave field polarizer that converts coupler fields to the polarization of the fast magnetosonic wave within the plasma. Theoretical estimates indicate that the folded waveguide is capable of high-efficiency, multimegawatt operation into a plasma. Bench tests have verified the predicted field structure within the waveguide in preparation for high-power tests on the Radio Frequency Test Facility at the Oak Ridge National Laboratory.

  2. Self-folding miniature elastic electric devices

    NASA Astrophysics Data System (ADS)

    Miyashita, Shuhei; Meeker, Laura; Tolley, Michael T.; Wood, Robert J.; Rus, Daniela

    2014-09-01

    Printing functional materials represents a considerable impact on the access to manufacturing technology. In this paper we present a methodology and validation of print-and-self-fold miniature electric devices. Polyvinyl chloride laminated sheets based on metalized polyester film show reliable self-folding processes under a heat application, and it configures 3D electric devices. We exemplify this technique by fabricating fundamental electric devices, namely a resistor, capacitor, and inductor. Namely, we show the development of a self-folded stretchable resistor, variable resistor, capacitive strain sensor, and an actuation mechanism consisting of a folded contractible solenoid coil. Because of their pre-defined kinematic design, these devices feature elasticity, making them suitable as sensors and actuators in flexible circuits. Finally, an RLC circuit obtained from the integration of developed devices is demonstrated, in which the coil based actuator is controlled by reading a capacitive strain sensor.

  3. Reinke Edema: Watch For Vocal Fold Cysts.

    PubMed

    Tüzüner, Arzu; Demirci, Sule; Yavanoglu, Ahmet; Kurkcuoglu, Melih; Arslan, Necmi

    2015-06-01

    Reinke edema is one of the common cause of dysphonia middle-aged population, and severe thickening of vocal folds require surgical treatment. Smoking plays a major role on etiology. Vocal fold cysts are also benign lesions and vocal trauma blamed for acquired cysts. We would like to present 3 cases with vocal fold cyst related with Reinke edema. First case had a subepidermal epidermoid cyst with Reinke edema, which could be easily observed before surgery during laryngostroboscopy. Second case had a mucous retention cyst into the edematous Reinke tissue, which was detected during surgical intervention, and third case had a epidermoid cyst that occurred 2 months after before microlaryngeal operation regarding Reinke edema reduction. These 3 cases revealed that surgical management of Reinke edema needs a careful dissection and close follow-up after surgery for presence of vocal fold cysts.

  4. Statistical properties of a folded elastic rod

    NASA Astrophysics Data System (ADS)

    Bayart, Elsa; Deboeuf, Stéphanie; Boué, Laurent; Corson, Francis; Boudaoud, Arezki; Adda-Bedia, Mokhtar

    2010-03-01

    A large variety of elastic structures naturally seem to be confined into environments too small to accommodate them; the geometry of folded structures span a wide range of length-scales. The elastic properties of these confined systems are further constrained by self-avoidance as well as by the dimensionality of both structures and container. To mimic crumpled paper, we devised an experimental setup to study the packing of a dimensional elastic object in 2D geometries: an elastic rod is folded at the center of a circular Hele-Shaw cell by a centripetal force. The initial configuration of the rod and the acceleration of the rotating disk allow to span different final folded configurations while the final rotation speed controls the packing intensity. Using image analysis we measure geometrical and mechanical properties of the folded configurations, focusing on length, curvature and energy distributions.

  5. Monster Mash: Protein Folding Gone Wrong

    MedlinePlus

    ... Articles | Inside Life Science Home Page Monster Mash: Protein Folding Gone Wrong By Joseph Piergrossi Posted October 31, 2013 In this image, globs of misfolded proteins called amyloid plaques (blobs) are found outside neurons ( ...

  6. Unexplained Profound Hypoglycemia After Vocal Fold Lipoinjection.

    PubMed

    Modanlou, Shohreh; Marie Giglio, Nicole; Carroll, Thomas; Pancaro, Carlo

    2016-02-01

    Vocal fold injection is used for the management of glottal incompetence from various causes. The procedure is well tolerated and has few reported complications. We present a case of a 66-year-old man with long-lasting hoarseness secondary to vocal fold atrophy, who underwent an uneventful bilateral vocal fold injection with autologous fat. While in the recovery area, he experienced profuse sweating approximately 30 minutes after the surgical procedure. His blood glucose value was measured at 24 mg/dL, and plasmatic insulin level was 246 mU/L. To our knowledge, this is the first reported case of a systemic side effect after vocal fold lipoinjection. PMID:26491839

  7. Topology Explains Why Automobile Sunshades Fold Oddly

    ERIC Educational Resources Information Center

    Feist, Curtis; Naimi, Ramin

    2009-01-01

    Automobile sunshades always fold into an "odd" number of loops. The explanation why involves elementary topology (braid theory and linking number, both explained in detail here with definitions and examples), and an elementary fact from algebra about symmetric group.

  8. Cellular Mechanisms of Membrane Protein Folding

    PubMed Central

    Skach, William R.

    2010-01-01

    The membrane protein folding problem can be articulated by two central questions. How is protein topology established by selective peptide transport to opposite sides of the cellular membrane? And how are transmembrane segments inserted, integrated and folded within the lipid bilayer? In eukaryotes, this process usually takes place in the endoplasmic reticulum (ER) coincident with protein synthesis, and is facilitated by the translating Ribosome and the Sec61 Translocon Complex (RTC). At its core, the RTC forms a dynamic pathway through which the elongating nascent polypeptide moves as it is delivered into cytosolic, lumenal and lipid compartments. This perspective will focus on emerging evidence that the RTC functions as a protein folding machine that restricts conformational space by establishing transmembrane topology and yet provides a permissive environment that enables nascent transmembrane domains to efficiently progress down their folding energy landscape. PMID:19491932

  9. Kinetic Analysis of Protein Folding Lattice Models

    NASA Astrophysics Data System (ADS)

    Chen, Hu; Zhou, Xin; Liaw, Chih Young; Koh, Chan Ghee

    Based on two-dimensional square lattice models of proteins, the relation between folding time and temperature is studied by Monte Carlo simulation. The results can be represented by a kinetic model with three states — random coil, molten globule, and native state. The folding process is composed of nonspecific collapse and final searching for the native state. At high temperature, it is easy to escape from local traps in the folding process. With decreasing temperature, because of the trapping in local traps, the final searching speed decreases. Then the folding shows chevron rollover. Through the analysis of the fitted parameters of the kinetic model, it is found that the main difference between the energy landscapes of the HP model and the Go model is that the number of local minima of the Go model is less than that of the HP model.

  10. First International Seminar on Non Tsetse-Transmitted Animal Trypanosomoses: conclusions and recommendations.

    PubMed

    Touratier, L

    1993-03-01

    The author presents the conclusions and recommendations of the First International Seminar on Non Tsetse-Transmitted Animal Trypanosomoses (NTTAT) held in Annecy (France) on 14-16 October 1992, at which twenty-two countries and five international organisations were represented. Recommendations were made on the topics examined during the six seminar sessions, namely: general aspects of NTTAT epidemiology and diagnosis chemotherapy basic research the current situation of NTTAT in various countries final conclusions. This seminar enabled participants to collate the information currently available on NTTAT and to discuss the present state of research on these infections.

  11. Folding funnels, binding funnels, and protein function.

    PubMed Central

    Tsai, C. J.; Kumar, S.; Ma, B.; Nussinov, R.

    1999-01-01

    Folding funnels have been the focus of considerable attention during the last few years. These have mostly been discussed in the general context of the theory of protein folding. Here we extend the utility of the concept of folding funnels, relating them to biological mechanisms and function. In particular, here we describe the shape of the funnels in light of protein synthesis and folding; flexibility, conformational diversity, and binding mechanisms; and the associated binding funnels, illustrating the multiple routes and the range of complexed conformers. Specifically, the walls of the folding funnels, their crevices, and bumps are related to the complexity of protein folding, and hence to sequential vs. nonsequential folding. Whereas the former is more frequently observed in eukaryotic proteins, where the rate of protein synthesis is slower, the latter is more frequent in prokaryotes, with faster translation rates. The bottoms of the funnels reflect the extent of the flexibility of the proteins. Rugged floors imply a range of conformational isomers, which may be close on the energy landscape. Rather than undergoing an induced fit binding mechanism, the conformational ensembles around the rugged bottoms argue that the conformers, which are most complementary to the ligand, will bind to it with the equilibrium shifting in their favor. Furthermore, depending on the extent of the ruggedness, or of the smoothness with only a few minima, we may infer nonspecific, broad range vs. specific binding. In particular, folding and binding are similar processes, with similar underlying principles. Hence, the shape of the folding funnel of the monomer enables making reasonable guesses regarding the shape of the corresponding binding funnel. Proteins having a broad range of binding, such as proteolytic enzymes or relatively nonspecific endonucleases, may be expected to have not only rugged floors in their folding funnels, but their binding funnels will also behave similarly

  12. The hydrogen exchange core and protein folding.

    PubMed Central

    Li, R.; Woodward, C.

    1999-01-01

    A database of hydrogen-deuterium exchange results has been compiled for proteins for which there are published rates of out-exchange in the native state, protection against exchange during folding, and out-exchange in partially folded forms. The question of whether the slow exchange core is the folding core (Woodward C, 1993, Trends Biochem Sci 18:359-360) is reexamined in a detailed comparison of the specific amide protons (NHs) and the elements of secondary structure on which they are located. For each pulsed exchange or competition experiment, probe NHs are shown explicitly; the large number and broad distribution of probe NHs support the validity of comparing out-exchange with pulsed-exchange/competition experiments. There is a strong tendency for the same elements of secondary structure to carry NHs most protected in the native state, NHs first protected during folding, and NHs most protected in partially folded species. There is not a one-to-one correspondence of individual NHs. Proteins for which there are published data for native state out-exchange and theta values are also reviewed. The elements of secondary structure containing the slowest exchanging NHs in native proteins tend to contain side chains with high theta values or be connected to a turn/loop with high theta values. A definition for a protein core is proposed, and the implications for protein folding are discussed. Apparently, during folding and in the native state, nonlocal interactions between core sequences are favored more than other possible nonlocal interactions. Other studies of partially folded bovine pancreatic trypsin inhibitor (Barbar E, Barany G, Woodward C, 1995, Biochemistry 34:11423-11434; Barber E, Hare M, Daragan V, Barany G, Woodward C, 1998, Biochemistry 37:7822-7833), suggest that developing cores have site-specific energy barriers between microstates, one disordered, and the other(s) more ordered. PMID:10452602

  13. [Surgery of benign vocal fold lesions].

    PubMed

    Olthoff, A

    2016-09-01

    Surgical treatment of benign vocal fold lesions can be indicated for clinical or functional reasons. The principles of phonosurgery have to be maintained in either case. The appropriate phonosurgical technique depends on the type of vocal fold lesion. Depending on the findings, phonosurgery aims to maintain or improve voice quality. The evaluation of clinical and functional results includes indirect laryngoscopy, videostroboscopy, and voice analysis. PMID:27552826

  14. On a smooth quintic 4-fold

    SciTech Connect

    Cheltsov, I A

    2000-10-31

    The birational geometry of an arbitrary smooth quintic 4-fold is studied using the properties of log pairs. As a result, a new proof of its birational rigidity is given and all birational maps of a smooth quintic 4-fold into fibrations with general fibre of Kodaira dimension zero are described. In the Addendum similar results are obtained for all smooth hypersurfaces of degree n in P{sup n} in the case of n equal to 6, 7, or 8.

  15. Muscular Anatomy of the Human Ventricular Folds

    PubMed Central

    Moon, Jerald; Alipour, Fariborz

    2013-01-01

    Objective The purpose of this study was to better understand the muscular anatomy of the ventricular folds (VF) to help improve biomechanical modeling of phonation and to better understand the role of these muscles during phonatory and non-phonatory tasks. Method Four human larynges were decalcified and sectioned coronally from the posterior to anterior using a CryoJane tape transfer system, and stained using Massons trichrome. The total and relative area of muscles observed in each section were calculated and used for characterizing muscle distribution within the ventricular folds. Results The ventricular folds of the larynges contained anteriorly coursing thyroarytenoid and ventricularis muscle fibers lying in the lower half of the VF posteriorly, with some ventricularis muscle evident in the upper and lateral portion of the fold more anteriorly. Very little muscle tissue was observed in the medial half of the fold, and the anterior half of the VF was largely devoid of any muscle tissue. All four VF’s contained muscle bundles coursing superiorly and medially through the upper half of the fold toward the lateral margin of the epiglottis. Conclusions While variability in expression was evident, the well-defined thyroarytenoid muscle was readily apparent lateral to the arytenoid cartilage in all specimens. PMID:24224399

  16. Protein Folding and Misfolding on Surfaces

    PubMed Central

    Stefani, Massimo

    2008-01-01

    Protein folding, misfolding and aggregation, as well as the way misfolded and aggregated proteins affects cell viability are emerging as key themes in molecular and structural biology and in molecular medicine. Recent advances in the knowledge of the biophysical basis of protein folding have led to propose the energy landscape theory which provides a consistent framework to better understand how a protein folds rapidly and efficiently to the compact, biologically active structure. The increased knowledge on protein folding has highlighted its strict relation to protein misfolding and aggregation, either process being in close competition with the other, both relying on the same physicochemical basis. The theory has also provided information to better understand the structural and environmental factors affecting protein folding resulting in protein misfolding and aggregation into ordered or disordered polymeric assemblies. Among these, particular importance is given to the effects of surfaces. The latter, in some cases make possible rapid and efficient protein folding but most often recruit proteins/peptides increasing their local concentration thus favouring misfolding and accelerating the rate of nucleation. It is also emerging that surfaces can modify the path of protein misfolding and aggregation generating oligomers and polymers structurally different from those arising in the bulk solution and endowed with different physical properties and cytotoxicities. PMID:19330090

  17. Structural Characteristics of Novel Protein Folds

    PubMed Central

    Fernandez-Fuentes, Narcis; Dybas, Joseph M.; Fiser, Andras

    2010-01-01

    Folds are the basic building blocks of protein structures. Understanding the emergence of novel protein folds is an important step towards understanding the rules governing the evolution of protein structure and function and for developing tools for protein structure modeling and design. We explored the frequency of occurrences of an exhaustively classified library of supersecondary structural elements (Smotifs), in protein structures, in order to identify features that would define a fold as novel compared to previously known structures. We found that a surprisingly small set of Smotifs is sufficient to describe all known folds. Furthermore, novel folds do not require novel Smotifs, but rather are a new combination of existing ones. Novel folds can be typified by the inclusion of a relatively higher number of rarely occurring Smotifs in their structures and, to a lesser extent, by a novel topological combination of commonly occurring Smotifs. When investigating the structural features of Smotifs, we found that the top 10% of most frequent ones have a higher fraction of internal contacts, while some of the most rare motifs are larger, and contain a longer loop region. PMID:20421995

  18. Optimum folding pathways for growing protein chains.

    PubMed

    Senturk, Serife; Baday, Sefer; Arkun, Yaman; Erman, Burak

    2007-11-26

    The folding of a protein is studied as it grows residue by residue from the N-terminus and enters an environment that stabilizes the folded state. This mode of folding of a growing chain is different from refolding where the full chain folds from a disordered initial configuration to the native state. We propose a sequential dynamic optimization method that computes the evolution of optimum folding pathways as amino acid residues are added to the peptide chain one by one. The dynamic optimization formulation is deterministic and uses Newton's equations of motion and a Go-type potential that establishes the native contacts and excluded volume effects. The method predicts the optimal energy-minimizing path among all the alternative feasible pathways. As two examples, the folding of the chicken villin headpiece, a 36-residue protein, and chymotrypsin inhibitor 2 (CI2), a 64-residue protein, are studied. Results on the villin headpiece show significant differences from the refolding of the same chain studied previously. Results on CI2 mostly agree with the results of refolding experiments and computational work.

  19. "Wet" Versus "Dry" Folding of Polyproline

    NASA Astrophysics Data System (ADS)

    Shi, Liuqing; Holliday, Alison E.; Bohrer, Brian C.; Kim, Doyong; Servage, Kelly A.; Russell, David H.; Clemmer, David E.

    2016-06-01

    When the all- cis polyproline-I helix (PPI, favored in 1-propanol) of polyproline-13 is introduced into water, it folds into the all- trans polyproline-II (PPII) helix through at least six intermediates [Shi, L., Holliday, A.E., Shi, H., Zhu, F., Ewing, M.A., Russell, D.H., Clemmer, D.E.: Characterizing intermediates along the transition from PPI to PPII using ion mobility-mass spectrometry. J. Am. Chem. Soc. 136, 12702-12711 (2014)]. Here, we show that the solvent-free intermediates refold into the all- cis PPI helix with high (>90%) efficiency. Moreover, in the absence of solvent, each intermediate appears to utilize the same small set of pathways observed for the solution-phase PPII → PPI transition upon immersion of PPIIaq in 1-propanol. That folding in solution (under conditions where water is displaced by propanol) and folding in vacuo (where energy required for folding is provided by collisional activation) occur along the same pathway is remarkable. Implicit in this statement is that 1-propanol mimics a "dry" environment, similar to the gas phase. We note that intermediates with structures that are similar to PPIIaq can form PPII under the most gentle activation conditions—indicating that some transitions observed in water (i.e. , "we t" folding, are accessible (albeit inefficient) in vacuo. Lastly, these "dry" folding experiments show that PPI (all cis) is favored under "dry" conditions, which underscores the role of water as the major factor promoting preference for trans proline.

  20. Folding of non-Euclidean curved shells

    NASA Astrophysics Data System (ADS)

    Bende, Nakul; Evans, Arthur; Innes-Gold, Sarah; Marin, Luis; Cohen, Itai; Santangelo, Christian; Hayward, Ryan

    2015-03-01

    Origami-based folding of 2D sheets has been of recent interest for a variety of applications ranging from deployable structures to self-folding robots. Though folding of planar sheets follows well-established principles, folding of curved shells involves an added level of complexity due to the inherent influence of curvature on mechanics. In this study, we use principles from differential geometry and thin shell mechanics to establish fundamental rules that govern folding of prototypical creased shells. In particular, we show how the normal curvature of a crease line controls whether the deformation is smooth or discontinuous, and investigate the influence of shell thickness and boundary conditions. We show that snap-folding of shells provides a route to rapid actuation on time-scales dictated by the speed of sound. The simple geometric design principles developed can be applied at any length-scale, offering potential for bio-inspired soft actuators for tunable optics, microfluidics, and robotics. This work was funded by the National Science Foundation through EFRI ODISSEI-1240441 with additional support to S.I.-G. through the UMass MRSEC DMR-0820506 REU program.

  1. An undergraduate neuroscience seminar based on the annual meeting of the society for neuroscience.

    PubMed

    Bucci, David J; Falls, William A

    2007-01-01

    We have recently planned and taught an advanced undergraduate seminar at our respective institutions that uses a unique mechanism to explore topics that are on the cutting edge of neuroscience. The course material is centered on the topics of presentations scheduled for the Annual Meeting of the Society for Neuroscience held each fall. The instructor and students (∼15) select several topics that are the subject of special lectures, panels, and keynote addresses included in the Program for the Annual Meeting. Each week the class reads and discusses several articles on the topic of one of the lectures, panels or addresses. By the time the Annual Meeting is held, the class is intimately familiar with the content of the planned presentations. The class then travels to the Annual Meeting and attends these presentations along with events of personal interest and keeps a journal of what they learn. Upon returning from the Annual Meeting, the students discuss the assigned presentations and also prepare and deliver their own presentation on a neuroscience topic of personal interest using information obtained at the meeting. Students also prepare an in-depth final paper on their presentation topic in the form of a Current Opinions in Neurobiology review article. The outcomes for the students are many fold: Students explore topics on the cutting edge of neuroscience through the review of primary literature and experience a major scientific conference first hand, which is attended by over 30,000 neuroscientists from around the world. This experience helps neuroscience "come alive" for the students and provides them with valuable opportunities to meet world-renowned researchers, prospective graduate mentors, and possibly future employers. Students also have the chance to develop important professional skills through critical evaluation of research, exposure to different presentation styles, and preparation of an in-depth research paper and oral presentation.

  2. Climate change and biodiversity seminar highlights knowns and unknowns

    NASA Astrophysics Data System (ADS)

    Weinstein, Alan

    Greenhouse gas emissions can be expected to warm the globe by about 2°C over the next 50-100 years. This could have such consequences as raising sea level by 44 cm, thereby affecting 70 million people and destroying the habitats of hundreds of species, increasing the occurrences of such diseases as malaria, and changing the economies of most of the world. All of the physical, chemical, biological, and economic forces at play here are highly nonlinear, leading to feedbacks that could alter all of the findings. These were some of the conclusions of a seminar on “Climate Change and Biodiversity,” which attracted over 130 scientists, engineers, and policy makers, mostly from the United Kingdom.

  3. Composting of municipal waste-water sludges. Seminar pub

    SciTech Connect

    Not Available

    1985-08-01

    This seminar publication provides practical information on current methods of composting municipal waste-water sludges. It is intended for government and private sector individuals involved in the planning, design, and operation of municipal sludge treatment and disposal systems. Chapter 1 presents general principles of the composting process and system design. Chapters 2 and 3 discuss in depth the experiences at the Dickerson, Western Branch, and Site II static-pile-composting operations in Maryland and at the windrow operation in Los Angeles County. In-vessel composting is reviewed in Chapter 4. Chapter 5 discusses current and proposed regulations and guidelines that pertain to sludge composting. The publication is not a design manual nor does it include all the latest knowledge about composting.

  4. Membership and attendance patterns in Tavistock Clinic general practitioner seminars

    PubMed Central

    Bourne, Stanford; di Perna, Nancy

    1980-01-01

    Patterns of recruitment and attendance (1951-79) of general practitioners at seminars at the Tavistock Clinic are analysed. Latterly about 40 general practitioners have attended each week; a turnover of about 15 join or leave each year; about 60 per cent stay at least two years and 40 per cent stay over three years. Half come from outside London. The ratio of men and women reflects the prevailing ratio in the profession. Most join five to 10 years after qualifying and younger general practitioners tend to leave early. At least seven per cent of recent members have left general practice; but the proportion involved in training, course organizing and the Royal College of General Practitioners is far above the average for all general practitioners. ImagesFigure 1. PMID:7441640

  5. Proceedings of the Space Station Freedom Clinical Experts Seminar

    NASA Technical Reports Server (NTRS)

    Billica, Roger P. (Editor); Lloyd, Charles W. (Editor); Doarn, Charles R. (Editor)

    1991-01-01

    These are the proceedings of the Space Station Freedom Health Maintenance Facility 1990 Clinical Experts Seminar held August 27-29, 1990, at the Nassau Bay Hilton, Houston, Texas. Contained within are the agenda, list of medical consultants, executive summary, individual presentations, and the comments generated from the working groups. Issues include the adequacy of current Health Maintenance Facility for Space Station Freedom; impact of having, or not having, an ACRV or physician on board Space Station Freedom; new and developing technologies, techniques, and medications and their impact on the evolving Space Station Freedom, considerations surrounding x-ray, ultrasound, lab, decontamination, blood transfusion, nutrition, safe-haven, computer/telemedicine; suggestions as to how to train the Crew Medical Officer; and, how the consultant network will interface over the next several years.

  6. Folding patterns and shape optimization using SMA-based self-folding laminates

    NASA Astrophysics Data System (ADS)

    Peraza-Hernandez, Edwin A.; Frei, Katherine R.; Hartl, Darren J.; Lagoudas, Dimitris C.

    2014-03-01

    Origami engineering, a discipline encompassing the creation of practical three-dimensional structures from two- dimensional entities via folding operations, has the potential to impact multiple fields of manufacturing and design. In some circumstances, it may be practical to have self-folding capabilities instead of creating folds by external manipulations (as in morphing structures in outer space or on the ocean floor). This paper considers the use of a self-folding laminate composite consisting of two outer layers of thermally actuated shape memory alloy (SMA) wire meshes separated by an inner compliant insulating layer. Methods for designing folding patterns and determining temperature fields to obtain desired shapes and behaviors are proposed. Sheets composed of the self-folding laminate are modeled via finite element analysis (FEA) and the proposed methods are implemented to test their capabilities. One method uses a previously developed and freely available software called Freeform Origami for folding pattern design. The second method entails the use of optimization to determine the localized activation temperatures required to obtain desired shapes or to perform specific functions. The proposed methods are demonstrated to be applicable for the design of folding patterns and determination of activation temperatures for the self-folding laminate by showing successful examples of their implementation. This exploratory study provides new tools that can be integrated into the design framework of self-folding origami structures.

  7. Cross folding in southern Bighorn basin

    SciTech Connect

    Gubbels, T.L.

    1986-08-01

    Analysis of Landsat Thematic Mapper imagery coupled with surface structural investigations of well-exposed folds in the southern Bighorn basin have revealed two northwest-trending folds that have been refolded. The eastern boundary of the Owl Creek Mountains is characterized by a well-defined alignment of folds that extend north-northwest from the Owl Creek thrust front. Bridger monocline, Wildhorse Butte anticline, and Red Hole anticline lie along this trend. Initial Laramide folding, probably during latest Cretaceous time, resulted in a single, continuous, north-northwest-trending anticline with a southwestward vergence. This anticline was progressively unfolded from south to north as the Owl Creek Range was thrust southward over the Wind River basin in earliest Eocene time; scissors-like vertical motion along this flexure rotated the axial surface of the early formed Bridger anticline, resulting in a monocline with a reversed vergence (northeastward). Formation of the Thermopolis/East Warm Springs anticline parallel to the north flank of the range accompanied thrusting and effectively refolded the northern end of the Wildhorse Butte anticline along an east-west axis. Faulting of the oversteepened south limb of the Red Hole cross fold was contemporaneous with folding. Cross-cutting fold axes in this area and the Mud Creek area to the west are best explained by a counterclockwise change in stress direction during the latest phase of the Laramide orogeny. Vertical movement along the eastern side of the Owl Creek Range results from differential motion in the hanging wall of the crystalline thrust sheet.

  8. Cellular folding pathway of a metastable serpin.

    PubMed

    Chandrasekhar, Kshama; Ke, Haiping; Wang, Ning; Goodwin, Theresa; Gierasch, Lila M; Gershenson, Anne; Hebert, Daniel N

    2016-06-01

    Although proteins generally fold to their thermodynamically most stable state, some metastable proteins populate higher free energy states. Conformational changes from metastable higher free energy states to lower free energy states with greater stability can then generate the work required to perform physiologically important functions. However, how metastable proteins fold to these higher free energy states in the cell and avoid more stable but inactive conformations is poorly understood. The serpin family of metastable protease inhibitors uses large conformational changes that are downhill in free energy to inhibit target proteases by pulling apart the protease active site. The serpin antithrombin III (ATIII) targets thrombin and other proteases involved in blood coagulation, and ATIII misfolding can thus lead to thrombosis and other diseases. ATIII has three disulfide bonds, two near the N terminus and one near the C terminus. Our studies of ATIII in-cell folding reveal a surprising, biased order of disulfide bond formation, with early formation of the C-terminal disulfide, before formation of the N-terminal disulfides, critical for folding to the active, metastable state. Early folding of the predominantly β-sheet ATIII domain in this two-domain protein constrains the reactive center loop (RCL), which contains the protease-binding site, ensuring that the RCL remains accessible. N-linked glycans and carbohydrate-binding molecular chaperones contribute to the efficient folding and secretion of functional ATIII. The inability of a number of disease-associated ATIII variants to navigate the folding reaction helps to explain their disease phenotypes. PMID:27222580

  9. African Seminar on Education for International Understanding at the Primary School Level.

    ERIC Educational Resources Information Center

    International Understanding at School, 1979

    1979-01-01

    Presents the text of a speech given by Dr. Taaitta Towett at the opening ceremony of a seminar on the promotion of education for international understanding in primary schools in January 1979 in Kenya. (CK)

  10. Expansion of the Role of Population Education Called for at the Regional Consultative Seminar.

    ERIC Educational Resources Information Center

    Population Education Newsletter and Forum, 1986

    1986-01-01

    Provides an overview of the deliberations, issues, and recommendations that occurred during a seminar on population education in Bangkok in 1986. Identifies specific actions that need to be taken in educational programs in Asia and in the Pacific. (ML)

  11. Seminar on the Associated Schools: N'Djamena, Chad, 4-6 May 1982.

    ERIC Educational Resources Information Center

    International Understanding at School, 1982

    1982-01-01

    Recommendations of a seminar held in N'Djamena, Chad, from May 4-6, 1982, to support the activities of the Associated Schools project intended to promote international understanding and peace are described. (RM)

  12. Medical students' attitudes about cosmetic pesticides before and after an ecosystem health seminar: a pilot study.

    PubMed

    Villela, Renata; Dimnik, Nadine; Ray, Anita; Howard, John; Stitt, Larry; Speechley, Mark

    2008-09-01

    The University of Western Ontario has incorporated ecosystem health as an integral component of its Community Health course for medical students. There is increasing concern regarding the negative health effects of pesticides. The issue of pesticides is, therefore, an obvious topic for the Community Health course. The goal of this pilot study was to compare the attitudes of medical students about cosmetic pesticide use before and after attending a special seminar on that topic. Sixty-three students were surveyed on their opinions before and after the pesticides seminar. After the seminar, the students' attitudes shifted towards a more negative view of unrestrained cosmetic pesticide use. The students also felt that there were greater risks involved with the use of pesticides (P < 0.001) after attending the seminar. The results of this pilot study demonstrate the need and the effectiveness of including ecosystem health topics in medical curricula.

  13. Distant Echo of a Strong Voice: Reflections on Margaret Mead's Evaluation of the Salzburg Seminar.

    ERIC Educational Resources Information Center

    Patton, Michael Quinn

    2003-01-01

    Comments on the evaluation by Margaret Mead of the first Salzburg Seminar (1947). Notes the strength and clarity of Mead's evaluation report, which was written without the aid of the many tools on which today's evaluators draw. (SLD)

  14. Estimation of vocal fold plane in 3D CT images for diagnosis of vocal fold abnormalities.

    PubMed

    Hewavitharanage, Sajini; Gubbi, Jayavardhana; Thyagarajan, Dominic; Lau, Ken; Palaniswami, Marimuthu

    2015-01-01

    Vocal folds are the key body structures that are responsible for phonation and regulating air movement into and out of lungs. Various vocal fold disorders may seriously impact the quality of life. When diagnosing vocal fold disorders, CT of the neck is the commonly used imaging method. However, vocal folds do not align with the normal axial plane of a neck and the plane containing vocal cords and arytenoids does vary during phonation. It is therefore important to generate an algorithm for detecting the actual plane containing vocal folds. In this paper, we propose a method to automatically estimate the vocal fold plane using vertebral column and anterior commissure localization. Gray-level thresholding, connected component analysis, rule based segmentation and unsupervised k-means clustering were used in the proposed algorithm. The anterior commissure segmentation method achieved an accuracy of 85%, a good estimate of the expert assessment. PMID:26736949

  15. Computational and theoretical methods for protein folding.

    PubMed

    Compiani, Mario; Capriotti, Emidio

    2013-12-01

    A computational approach is essential whenever the complexity of the process under study is such that direct theoretical or experimental approaches are not viable. This is the case for protein folding, for which a significant amount of data are being collected. This paper reports on the essential role of in silico methods and the unprecedented interplay of computational and theoretical approaches, which is a defining point of the interdisciplinary investigations of the protein folding process. Besides giving an overview of the available computational methods and tools, we argue that computation plays not merely an ancillary role but has a more constructive function in that computational work may precede theory and experiments. More precisely, computation can provide the primary conceptual clues to inspire subsequent theoretical and experimental work even in a case where no preexisting evidence or theoretical frameworks are available. This is cogently manifested in the application of machine learning methods to come to grips with the folding dynamics. These close relationships suggested complementing the review of computational methods within the appropriate theoretical context to provide a self-contained outlook of the basic concepts that have converged into a unified description of folding and have grown in a synergic relationship with their computational counterpart. Finally, the advantages and limitations of current computational methodologies are discussed to show how the smart analysis of large amounts of data and the development of more effective algorithms can improve our understanding of protein folding.

  16. Protein Folding and Mechanisms of Proteostasis

    PubMed Central

    Díaz-Villanueva, José Fernando; Díaz-Molina, Raúl; García-González, Victor

    2015-01-01

    Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious cell processes. Therefore in recent years the etiology of a great number of diseases has been attributed to failures in mechanisms that modulate protein structure. Interconnections among metabolic and cell signaling pathways are critical for homeostasis to converge on mechanisms associated with protein folding as well as for the preservation of the native structure of proteins. For instance, imbalances in secretory protein synthesis pathways lead to a condition known as endoplasmic reticulum (ER) stress which elicits the adaptive unfolded protein response (UPR). Therefore, taking this into consideration, a key part of this paper is developed around the protein folding phenomenon, and cellular mechanisms which support this pivotal condition. We provide an overview of chaperone protein function, UPR via, spatial compartmentalization of protein folding, proteasome role, autophagy, as well as the intertwining between these processes. Several diseases are known to have a molecular etiology in the malfunction of mechanisms responsible for protein folding and in the shielding of native structure, phenomena which ultimately lead to misfolded protein accumulation. This review centers on our current knowledge about pathways that modulate protein folding, and cell responses involved in protein homeostasis. PMID:26225966

  17. Experimental investigation of protein folding and misfolding.

    PubMed

    Dobson, Christopher M

    2004-09-01

    Newly synthesised proteins need to fold, often to intricate and close-packed structures, in order to function. The underlying mechanism by which this complex process takes place both in vitro and in vivo is now becoming understood, at least in general terms, as a result of the application of a wide range of biophysical and computational methods used in combination with the techniques of biochemistry and protein engineering. It is increasingly apparent, however, that folding is not only crucial for generating biological activity, but that it is also coupled to a wide range of processes within the cell, ranging from the trafficking of proteins to specific organelles to the regulation of cell growth and differentiation. Not surprisingly, therefore, the failure of proteins to fold appropriately, or to remain correctly folded, is associated with a large number of cellular malfunctions that give rise to disease. Misfolding, and its consequences such as aggregation, can be investigated by extending the types of techniques used to study the normal folding process. Application of these techniques is enabling the development of a unified description of the interconversion and regulation of the different conformational states available to proteins in living systems. Such a description proves a generic basis for understanding the fundamental links between protein misfolding and its associated clinical disorders, such as Alzheimer's disease and Type II diabetes, and for exploring novel therapeutic strategies directed at their prevention and treatment on a rational basis.

  18. A sweet code for glycoprotein folding.

    PubMed

    Caramelo, Julio J; Parodi, Armando J

    2015-11-14

    Glycoprotein synthesis is initiated in the endoplasmic reticulum (ER) lumen upon transfer of a glycan (Glc3Man9GlcNAc2) from a lipid derivative to Asn residues (N-glycosylation). N-Glycan-dependent quality control of glycoprotein folding in the ER prevents exit to Golgi of folding intermediates, irreparably misfolded glycoproteins and incompletely assembled multimeric complexes. It also enhances folding efficiency by preventing aggregation and facilitating formation of proper disulfide bonds. The control mechanism essentially involves four components, resident lectin-chaperones (calnexin and calreticulin) that recognize monoglucosylated polymannose protein-linked glycans, lectin-associated oxidoreductase acting on monoglucosylated glycoproteins (ERp57), a glucosyltransferase that creates monoglucosylated epitopes in protein-linked glycans (UGGT) and a glucosidase (GII) that removes the glucose units added by UGGT. This last enzyme is the only mechanism component sensing glycoprotein conformations as it creates monoglucosylated glycans exclusively in not properly folded glycoproteins or in not completely assembled multimeric glycoprotein complexes. Glycoproteins that fail to properly fold are eventually driven to proteasomal degradation in the cytosol following the ER-associated degradation pathway, in which the extent of N-glycan demannosylation by ER mannosidases play a relevant role in the identification of irreparably misfolded glycoproteins.

  19. Petrofabric test of viscous folding theory

    NASA Astrophysics Data System (ADS)

    Onasch, Charles M.

    1984-06-01

    Compression and extension axes are deduced from quartz deformation lamellae in a quartzite and a graywacke folded into an asymetrical syncline. Deformation lamellae fabrics in the two sandstones are distinctly different. In the graywacke, regardless of bedding orientation or position on the fold, compression axes are normal or nearly normal to the axial planar rough cleavage. Extension axes generally lie in the cleavage plane, parallel to dip. In most quartzite samples, compression axes are parallel or subparallel to bedding, at high angles to the fold axis and extension axes are normal to bedding. Two samples from the very base of the formation indicate compression parallel to the fold axis with extension parallel to bedding, at high angles to the fold axis. One of these two shows both patterns. The lamellae fabric geometry in these two samples suggests the presence of a neutral surface in the quartzite. The lamellae-derived compression and extension axes are in good agreement with the buckling behavior of a viscous layer (quartzite) embedded in a less viscous medium (graywacke and shale below and shale and carbonate above).

  20. Nonlinear Models for Protein Folding and Function

    NASA Astrophysics Data System (ADS)

    Cruzeiro, L.

    Earlier a specific kinetic process for reproducible protein folding was proposed according to which the nascent chain is helical and the first step in in vivo protein folding is the bending of the initial helix at specific amino acid sites. Here the theoretical feasibility of this kinetic process is tested. To that end, two proteins, one belonging to the mainly α class and the other belonging to the α/β class, are selected and targeted molecular dynamics is applied to generate folding pathways for those two proteins, starting from two well defined initial conformations: a fully extended and a α-helical conformation. Not only are the native states closer to an initial helical structure for both proteins but also the pathways from the α-helical initial conformation to the native state have lower potential energy than the pathways that start from the fully extended conformation. For the α/β protein, 30% (40%) of the pathways from an initial α-helix (fully extended) structure lead to unentangled native folds, a success rate that can be increased to 85% by the introduction of a putative intermediate structure. These results lend support to the kinetic process proposed and open up a new direction in which to look for a solution to the protein folding problem. The chapter ends with a section that emphasizes the formal similarities between the dynamics quantum vibrational excited states in proteins and electrons in nonlinear lattices.

  1. Towards a systematic classification of protein folds

    NASA Astrophysics Data System (ADS)

    Lindgård, Per-Anker; Bohr, Henrik

    1997-10-01

    A lattice model Hamiltonian is suggested for protein structures that can explain the division into structural fold classes during the folding process. Proteins are described by chains of secondary structure elements, with the hinges in between being the important degrees of freedom. The protein structures are given a unique name, which simultaneously represent a linear string of physical coupling constants describing hinge spin interactions. We have defined a metric and a precise distance measure between the fold classes. An automated procedure is constructed in which any protein structure in the usual protein data base coordinate format can be transformed into the proposed chain representation. Taking into account hydrophobic forces we have found a mechanism for the formation of domains with a unique fold containing predicted magic numbers \\{4,6,9,12,16,18,...\\} of secondary structures and multiples of these domains. It is shown that the same magic numbers are robust and occur as well for packing on other nonclosed packed lattices. We have performed a statistical analysis of available protein structures and found agreement with the predicted preferred abundances of proteins with a predicted magic number of secondary structures. Thermodynamic arguments for the increased abundance and a phase diagram for the folding scenario are given. This includes an intermediate high symmetry phase, the parent structures, between the molten globule and the native states. We have made an exhaustive enumeration of dense lattice animals on a cubic lattice for acceptance number Z=4 and Z=5 up to 36 vertices.

  2. East Africa seminar and workshop of remote sensing of natural resources and environment

    USGS Publications Warehouse

    Deutsch, Morris

    1975-01-01

    Report on total program covering East Africa Seminar and Workshop on remote sensing of natural resources and the environment held in Nairobi, Kenya, March 21 April 3, 1974, attended by participants from 10 English-speaking African nations. Appendices are included for Seminar proceedings, workshop lectures and outlines, field trip reports and critiques by participants, and reports on potential applications of an operational earth resources satellite for the participating countries.

  3. [Seminar on the significance and possibilities for using the results of population and housing censuses].

    PubMed

    Stortzbach, B

    1989-07-01

    Summaries are presented from a seminar held in Wiesbaden, West Germany, in April 1989. The seminar was sponsored by the U.N. Economic Commission for Europe and the Conference of European Statisticians. Topics covered include the significance and use of population census results, possibilities of replacing censuses with surveys or registers, possibilities of improving and reducing the costs of censuses, public acceptance of the census, and the distribution of census results.

  4. Proteopedia: Rossmann Fold: A Beta-Alpha-Beta Fold at Dinucleotide Binding Sites

    ERIC Educational Resources Information Center

    Hanukoglu, Israel

    2015-01-01

    The Rossmann fold is one of the most common and widely distributed super-secondary structures. It is composed of a series of alternating beta strand (ß) and alpha helical (a) segments wherein the ß-strands are hydrogen bonded forming a ß-sheet. The initial beta-alpha-beta (ßaß) fold is the most conserved segment of Rossmann folds. As this segment…

  5. Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome

    PubMed Central

    Elcock, Adrian H

    2006-01-01

    Although molecular simulation methods have yielded valuable insights into mechanistic aspects of protein refolding in vitro, they have up to now not been used to model the folding of proteins as they are actually synthesized by the ribosome. To address this issue, we report here simulation studies of three model proteins: chymotrypsin inhibitor 2 (CI2), barnase, and Semliki forest virus protein (SFVP), and directly compare their folding during ribosome-mediated synthesis with their refolding from random, denatured conformations. To calibrate the methodology, simulations are first compared with in vitro data on the folding stabilities of N-terminal fragments of CI2 and barnase; the simulations reproduce the fact that both the stability and thermal folding cooperativity increase as fragments increase in length. Coupled simulations of synthesis and folding for the same two proteins are then described, showing that both fold essentially post-translationally, with mechanisms effectively identical to those for refolding. In both cases, confinement of the nascent polypeptide chain within the ribosome tunnel does not appear to promote significant formation of native structure during synthesis; there are however clear indications that the formation of structure within the nascent chain is sensitive to location within the ribosome tunnel, being subject to both gain and loss as the chain lengthens. Interestingly, simulations in which CI2 is artificially stabilized show a pronounced tendency to become trapped within the tunnel in partially folded conformations: non-cooperative folding, therefore, appears in the simulations to exert a detrimental effect on the rate at which fully folded conformations are formed. Finally, simulations of the two-domain protease module of SFVP, which experimentally folds cotranslationally, indicate that for multi-domain proteins, ribosome-mediated folding may follow different pathways from those taken during refolding. Taken together, these

  6. Non-cylindrical fold growth in the Zagros fold and thrust belt (Kurdistan, NE-Iraq)

    NASA Astrophysics Data System (ADS)

    Bartl, Nikolaus; Bretis, Bernhard; Grasemann, Bernhard; Lockhart, Duncan

    2010-05-01

    The Zagros mountains extends over 1800 km from Kurdistan in N-Iraq to the Strait of Hormuz in Iran and is one of the world most promising regions for the future hydrocarbon exploration. The Zagros Mountains started to form as a result of the collision between the Eurasian and Arabian Plates, whose convergence began in the Late Cretaceous as part of the Alpine-Himalayan orogenic system. Geodetic and seismological data document that both plates are still converging and that the fold and thrust belt of the Zagros is actively growing. Extensive hydrocarbon exploration mainly focuses on the antiforms of this fold and thrust belt and therefore the growth history of the folds is of great importance. This work investigates by means of structural field work and quantitative geomorphological techniques the progressive fold growth of the Permam, Bana Bawi- and Safeen- Anticlines located in the NE of the city of Erbil in the Kurdistan region of Northern Iraq. This part of the Zagros fold and thrust belt belongs to the so-called Simply Folded Belt, which is dominated by gentle to open folding. Faults or fault related folds have only minor importance. The mechanical anisotropy of the formations consisting of a succession of relatively competent (massive dolomite and limestone) and incompetent (claystone and siltstone) sediments essentially controls the deformation pattern with open to gentle parallel folding of the competent layers and flexural flow folding of the incompetent layers. The characteristic wavelength of the fold trains is around 10 km. Due to faster erosion of the softer rock layers in the folded sequence, the more competent lithologies form sharp ridges with steeply sloping sides along the eroded flanks of the anticlines. Using an ASTER digital elevation model in combination with geological field data we quantified 250 drainage basins along the different limbs of the subcylindrical Permam, Bana Bawi- and Safeen- Anticlines. Geomorphological indices of the drainage

  7. Influence of the ventricular folds on a voice source with specified vocal fold motion1

    PubMed Central

    McGowan, Richard S.; Howe, Michael S.

    2010-01-01

    The unsteady drag on the vocal folds is the major source of sound during voiced speech. The drag force is caused by vortex shedding from the vocal folds. The influence of the ventricular folds (i.e., the “false” vocal folds that protrude into the vocal tract a short distance downstream of the glottis) on the drag and the voice source are examined in this paper by means of a theoretical model involving vortex sheets in a two-dimensional geometry. The effect of the ventricular folds on the output acoustic pressure is found to be small when the movement of the vocal folds is prescribed. It is argued that the effect remains small when fluid-structure interactions account for vocal fold movement. These conclusions can be justified mathematically when the characteristic time scale for change in the velocity of the glottal jet is large compared to the time it takes for a vortex disturbance to be convected through the vocal fold and ventricular fold region. PMID:20329852

  8. Report on the Dagstuhl Seminar on Visualization and Monitoring of Network Traffic

    SciTech Connect

    Keim, Daniel; Pras, Aiko; Schonwalder, Jurgen; Wong, Pak C.; Mansmann, Florian

    2011-01-26

    The Dagstuhl Seminar on Visualization and Monitoring of Network Traffic [1] took place May 17-20, 2009 in Dagstuhl, Germany. Dagstuhl seminars promote personal interaction and open discussion of results as well as new ideas. Unlike at most conferences, the focus is not solely on the presentation of established results but to equal parts on results, ideas, sketches, and open problems. The aim of this particular seminar was to bring together experts from the information visualization community and the networking community in order to discuss the state of the art of monitoring and visualization of network traffic. People from the different research communities involved jointly organized the seminar. The co-chairs of the seminar from the networking community were Aiko Pras (University of Twente) and Jürgen Schönwälder (Jacobs University Bremen). The co-chairs from the visualization community were Daniel A. Keim (University of Konstanz) and Pak Chung Wong (Pacific Northwest National Lab). Florian Mansmann (University of Konstanz) helped with producing this report. The seminar was organized and supported by Schloss Dagstuhl and the EC IST-EMANICS Network of Excellence [1].

  9. An agromedicine initiative for first-year medical students, 1998-2004: biochemistry seminar proves feasible.

    PubMed

    Simpson, William M; Shepard, B Merle; Rushing, James W; Schuman, Stanley H

    2006-01-01

    This report describes a 20 class-hour, 10-session seminar on agromedicine-oriented topics, delivered as part of a basic science course for medical students (biochemistry) at the Medical University of South Carolina. The course was initiated in 1998 and continued through 2004. The preceptors are family medicine and agricultural research professors. Concepts from primary care, epidemiology, entomology, toxicology, and food science appeal strongly to the first-year medical student group (limited to 10 students). The agromedicine/environmental medicine seminar series is one of 16 research seminars available for in-depth study. As part of the course in biochemistry, this seminar has earned positive evaluations from medical students who expect to widen their perspective on global health and the environment. Seminar topics include food safety, farm trauma, nutraceuticals, crop protection, insect-borne disease, occupational health and safety, diet and cancer, birth defects, and bioengineering. Seventy medical students have participated in the interdisciplinary seminar. They perceive environmental science as affecting the health of their patients and as an essential part of their preparation for curative and preventive medicine. Readers may find medical school curriculum committees more receptive to accepting and continuing an agromedicine offering if it can be incorporated in a basic science course such as biochemistry or pharmacology.

  10. FOREWORD: International Scientific Seminars on "Fundamental and Applied Problems of Photonics and Condensed Matter Physics"

    NASA Astrophysics Data System (ADS)

    Yurchenko, Stanislav; Ryzhii, Viktor

    2015-01-01

    International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics'' were held in Bauman Moscow State Technical University (BMSTU) in May - June 2014. The idea of the Seminars was to organize a series of meetings between young scientists and discuss actual problems and the latest results in Photonics and Condensed Matter Physics. There were eight Sessions: Modern Problems of Condensed Matter Physics; Laser Physics; Spectroscopy of Condensed Matter; Terahertz Optical Technology; Optical Signals Processing; Physics of Optical Strong Correlated Systems; Complex Dusty Plasma Physics; Biomediacal Applications of Photonics. Seminars were organized by the young group of scientists and students from Research and Educational Center ''Photonics and Infrared Technology'' at BMSTU. It brought a significant contribution to the development of youth science in the field of Physics and Photonics in Russia. More than 100 young scientists and students participated in the Seminars in spring - summer 2014. The International Scientific Seminars were supported by the Russian Foundation for Basic Research (grant # 14-08-06030-g). This volume contains proceedings of the International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics''. Stanislav Yurchenko and Viktor Ryzhii Bauman Moscow State Technical University

  11. Thermal stability of idealized folded carbyne loops

    PubMed Central

    2013-01-01

    Self-unfolding items provide a practical convenience, wherein ring-like frames are contorted into a state of equilibrium and subsequently  pop up’ or deploy when perturbed from a folded structure. Can the same process be exploited at the molecular scale? At the limiting scale is a closed chain of single atoms, used here to investigate the limits of stability of such folded ring structures via full atomistic molecular dynamics. Carbyne is a one-dimensional carbon allotrope composed of sp-hybridized carbon atoms. Here, we explore the stability of idealized carbyne loops as a function of chain length, curvature, and temperature, and delineate an effective phase diagram between folded and unfolded states. We find that while overall curvature is reduced, in addition to torsional and self-adhesive energy barriers, a local increase in curvature results in the largest impedance to unfolding. PMID:24252156

  12. Microbial Manipulation of the Amyloid Fold

    PubMed Central

    DePas, William H.

    2012-01-01

    Microbial biofilms are encased in a protein, DNA and polysaccharide matrix that protects the community, promotes interactions with the environment, and helps cells to adhere together. The protein component of these matrices is often a remarkably stable, β-sheet-rich polymer called amyloid. Amyloids form ordered, self-templating fibers that are highly aggregative, making them a valuable biofilm component. Some eukaryotic proteins inappropriately adopt the amyloid fold and these misfolded protein aggregates disrupt normal cellular proteostasis, which can cause significant cytotoxicity. Indeed, until recently amyloids were considered solely the result of protein misfolding. However, research over the past decade has revealed how various organisms have capitalized on the amyloid fold by developing sophisticated biogenesis pathways that coordinate gene expression, protein folding, and secretion so that amyloid-related toxicities are minimized. How microbes manipulate amyloids, by augmenting their advantageous properties and by reducing their undesirable properties, will be the subject of this review. PMID:23108148

  13. Transversal Clifford gates on folded surface codes

    NASA Astrophysics Data System (ADS)

    Moussa, Jonathan E.

    2016-10-01

    Surface and color codes are two forms of topological quantum error correction in two spatial dimensions with complementary properties. Surface codes have lower-depth error detection circuits and well-developed decoders to interpret and correct errors, while color codes have transversal Clifford gates and better code efficiency in the number of physical qubits needed to achieve a given code distance. A formal equivalence exists between color codes and folded surface codes, but it does not guarantee the transferability of any of these favorable properties. However, the equivalence does imply the existence of constant-depth circuit implementations of logical Clifford gates on folded surface codes. We achieve and improve this result by constructing two families of folded surface codes with transversal Clifford gates. This construction is presented generally for qudits of any dimension. The specific application of these codes to universal quantum computation based on qubit fusion is also discussed.

  14. Kinetics of Peptide Folding in Lipid Membranes

    PubMed Central

    Oh, Kwang-Im; Smith-Dupont, Kathryn B.; Markiewicz, Beatrice N.; Gai, Feng

    2015-01-01

    Despite our extensive understanding of water-soluble protein folding kinetics, much less is known about the folding dynamics and mechanisms of membrane proteins. However, recent studies have shown that for relatively simple systems, such as peptides that form a transmembrane α-helix, helical dimer, or helix-turn-helix, it is possible to assess the kinetics of several important steps, including peptide binding to the membrane from aqueous solution, peptide folding on the membrane surface, helix insertion into the membrane, and helix-helix association inside the membrane. Herein, we provide a brief review of these studies and also suggest new initiation and probing methods that could lead to improved temporal and structural resolution in future experiments. PMID:25808575

  15. Stretching and folding in finite time.

    PubMed

    Ma, Tian; Ouellette, Nicholas T; Bollt, Erik M

    2016-02-01

    Complex flows mix efficiently, and this process can be understood by considering the stretching and folding of material volumes. Although many metrics have been devised to characterize stretching, fewer are able to capture folding in a quantitative way in spatiotemporally variable flows. Here, we extend our previous methods based on the finite-time curving of fluid-element trajectories to nonzero scales and show that this finite-scale finite-time curvature contains information about both stretching and folding. We compare this metric to the more commonly used finite-time Lyapunov exponent and illustrate our methods using experimental flow-field data from a quasi-two-dimensional laboratory flow. Our new analysis tools add to the growing set of Lagrangian methods for characterizing mixing in complex, aperiodic fluid flows.

  16. Exact folded-band chaotic oscillator

    NASA Astrophysics Data System (ADS)

    Corron, Ned J.; Blakely, Jonathan N.

    2012-06-01

    An exactly solvable chaotic oscillator with folded-band dynamics is shown. The oscillator is a hybrid dynamical system containing a linear ordinary differential equation and a nonlinear switching condition. Bounded oscillations are provably chaotic, and successive waveform maxima yield a one-dimensional piecewise-linear return map with segments of both positive and negative slopes. Continuous-time dynamics exhibit a folded-band topology similar to Rössler's oscillator. An exact solution is written as a linear convolution of a fixed basis pulse and a discrete binary sequence, from which an equivalent symbolic dynamics is obtained. The folded-band topology is shown to be dependent on the symbol grammar.

  17. Effects of Knots on Protein Folding Properties

    PubMed Central

    Soler, Miguel A.; Faísca, Patrícia F. N.

    2013-01-01

    This work explores the impact of knots, knot depth and motif of the threading terminus in protein folding properties (kinetics, thermodynamics and mechanism) via extensive Monte Carlo simulations of lattice models. A knotted backbone has no effect on protein thermodynamic stability but it may affect key aspects of folding kinetics. In this regard, we found clear evidence for a functional advantage of knots: knots enhance kinetic stability because a knotted protein unfolds at a distinctively slower rate than its unknotted counterpart. However, an increase in knot deepness does not necessarily lead to more effective changes in folding properties. In this regard, a terminus with a non-trivial conformation (e.g. hairpin) can have a more dramatic effect in enhancing kinetic stability than knot depth. Nevertheless, our results suggest that the probability of the denatured ensemble to keep knotted is higher for proteins with deeper knots, indicating that knot depth plays a role in determining the topology of the denatured state. Refolding simulations starting from denatured knotted conformations show that not every knot is able to nucleate folding and further indicate that the formation of the knotting loop is a key event in the folding of knotted trefoils. They also show that there are specific native contacts within the knotted core that are crucial to keep a native knotting loop in denatured conformations which otherwise have no detectable structure. The study of the knotting mechanism reveals that the threading of the knotting loop generally occurs towards late folding in conformations that exhibit a significant degree of structural consolidation. PMID:24023962

  18. Ontogeny of the mouse vocal fold epithelium

    PubMed Central

    Lungova, Vlasta; Verheyden, Jamie M.; Herriges, John; Sun, Xin; Thibeault, Susan L.

    2015-01-01

    This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. We define five principal developmental events that constitute the progression from VF initiation in the embryonic anterior foregut tube to fully differentiated and functional adult tissue. These developmental events include (1) the initiation of the larynx and vocal folds with apposition of the lateral walls of the primitive laryngopharynx (embryonic (E) day 10.5); (2) the establishment of the epithelial lamina with fusion of the lateral walls of the primitive laryngopharynx (E11.5); (3) the epithelial lamina recanalization and separation of VFs (E13.5–18.5); (4) the stratification of the vocal folds (E13.5–18.5); and (5) the maturation of vocal fold epithelium (postnatal stages). The illustration of these morphogenetic events is substantiated by dynamic changes in cell proliferation and apoptosis, as well as the expression pattern of key transcription factors, FOXA2, SOX2 and NKX2-1 that specify and pattern the foregut endoderm. Furthermore, we documented the gradual conversion of VF epithelial cells from simple precursors expressing cytokeratins 8 and 18 in the embryo into mature stratified epithelial cells also expressing cytokeratins 5 and 14 in the adult. Interestingly, in the adult, cytokeratins 5 and 14 appear to be expressed in all cell layers in the VF, in contrast to their preferential localization to the basal cell layer in surrounding epithelium. To begin investigating the role of signaling molecules in vocal fold development, we characterized the expression pattern of SHH pathway genes, and how loss of Shh affects vocal fold development in the mutant. This study defines the cellular and molecular context and serves as the necessary foundation for future functional investigations of VF formation. PMID:25601450

  19. Circular permutant GFP insertion folding reporters

    DOEpatents

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2008-06-24

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  20. Circular permutant GFP insertion folding reporters

    SciTech Connect

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2013-04-16

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  1. Circular permutant GFP insertion folding reporters

    SciTech Connect

    Waldo, Geoffrey S; Cabantous, Stephanie

    2013-02-12

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  2. Circular permutant GFP insertion folding reporters

    SciTech Connect

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2011-06-14

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  3. Control of folding by gravity and matrix thickness: Implications for large-scale folding

    NASA Astrophysics Data System (ADS)

    Schmalholz, S. M.; Podladchikov, Y. Y.; Burg, J.-P.

    2002-01-01

    We show that folding of a non-Newtonian layer resting on a homogeneous Newtonian matrix with finite thickness under influence of gravity can occur by three modes: (1) matrix-controlled folding, dependent on the effective viscosity contrast between layer and matrix, (2) gravity-controlled folding, dependent on the Argand number (the ratio of the stress caused by gravity to the stress caused by shortening), and (3) detachment folding, dependent on the ratio of matrix thickness to layer thickness. We construct a phase diagram that defines the transitions between each of the three folding modes. Our priority is transparency of the analytical derivations (e.g., thin-plate versus thick-plate approximations), which permits complete classification of the folding modes involving a minimum number of dimensionless parameters. Accuracy and sensitivity of the analytical results to model assumptions are investigated. In particular, depth dependence of matrix rheology is only important for folding over a narrow range of material parameters. In contrast, strong depth dependence of the viscosity of the folding layer limits applicability of ductile rheology and leads to a viscoelastic transition. Our theory is applied to estimate the effective thickness of the folded central Asian upper crust using the ratio of topographic wavelength to Moho depth. Phase diagrams based on geometrical parameters show that gravity does not significantly control folding in the Jura and the Zagros Mountains but does control folding in central Asia. Applicability conditions of viscous and thin sheet models for large-scale lithospheric deformation, derived in terms of the Argand number, have implications for the plate-like style of planetary tectonics.

  4. Fold in Origami and Unfold Math

    ERIC Educational Resources Information Center

    Georgeson, Joseph

    2011-01-01

    Students enjoy origami and like making everything from paper cranes to footballs out of small, colorful squares of paper. They can invent their own shapes and are intrigued by the polyhedrons that they can construct. Paper folding is fun, but where is the math? Unless teachers develop lessons that address mathematical objectives, origami could be…

  5. Role of cofactors in metalloprotein folding.

    PubMed

    Wilson, Corey J; Apiyo, David; Wittung-Stafshede, Pernilla

    2004-01-01

    Metals are commonly found as natural constituents of proteins. Since many such metals can interact specifically with their corresponding unfolded proteins in vitro , cofactor-binding prior to polypeptide folding may be a biological path to active metalloproteins. By interacting with the unfolded polypeptide, the metal may create local structure that initiates and directs the polypeptide-folding process. Here, we review recent literature that addresses the involvement of metals in protein-folding reactions in vitro . To date, the best characterized systems are simple one such as blue-copper proteins, heme-binding proteins, iron-sulfur-cluster proteins and synthetic metallopeptides. Taken together, the available data demonstrates that metals can play diverse roles: it is clear that many cofactors bind before polypeptide folding and influence the reaction; yet, some do not bind until a well-structured active site is formed. The significance of characterizing the effects of metals on protein conformational changes is underscored by the many human diseases that are directly linked to anomalous protein-metal interactions.

  6. Folded-path optical analysis gas cell

    DOEpatents

    Carangelo, Robert M.; Wright, David D.

    1995-01-01

    A folded-path gas cell employs an elliptical concave mirror in confronting relationship to two substantially spherical concave mirrors. At least one of the spherical mirrors, and usually both, are formed with an added cylindrical component to increase orthogonal focii coincidence and thereby to increase the radiation energy throughput characteristic of the cell.

  7. Hydroxyapatite surface-induced peptide folding.

    PubMed

    Capriotti, Lisa A; Beebe, Thomas P; Schneider, Joel P

    2007-04-25

    Herein, we describe the design and surface-binding characterization of a de novo designed peptide, JAK1, which undergoes surface-induced folding at the hydroxyapatite (HA)-solution interface. JAK1 is designed to be unstructured in buffered saline solution, yet undergo HA-induced folding that is largely governed by the periodic positioning of gamma-carboxyglutamic acid (Gla) residues within the primary sequence of the peptide. Circular dichroism (CD) spectroscopy and analytical ultracentrifugation indicate that the peptide remains unfolded and monomeric in solution under normal physiological conditions; however, CD spectroscopy indicates that in the presence of hydroxyapatite, the peptide avidly binds to the mineral surface adopting a helical structure. Adsorption isotherms indicate nearly quantitative surface coverage and Kd = 310 nM for the peptide-surface binding event. X-ray photoelectron spectroscopy (XPS) coupled with the adsorption isotherm data suggests that JAK1 binds to HA, forming a self-limiting monolayer. This study demonstrates the feasibility of using HA surfaces to trigger the intramolecular folding of designed peptides and represents the initial stages of defining the design rules that allow HA-induced peptide folding.

  8. Folding and faulting of an elastic continuum

    PubMed Central

    Gourgiotis, Panos A.

    2016-01-01

    Folding is a process in which bending is localized at sharp edges separated by almost undeformed elements. This process is rarely encountered in Nature, although some exceptions can be found in unusual layered rock formations (called ‘chevrons’) and seashell patterns (for instance Lopha cristagalli). In mechanics, the bending of a three-dimensional elastic solid is common (for example, in bulk wave propagation), but folding is usually not achieved. In this article, the route leading to folding is shown for an elastic solid obeying the couple-stress theory with an extreme anisotropy. This result is obtained with a perturbation technique, which involves the derivation of new two-dimensional Green's functions for applied concentrated force and moment. While the former perturbation reveals folding, the latter shows that a material in an extreme anisotropic state is also prone to a faulting instability, in which a displacement step of finite size emerges. Another failure mechanism, namely the formation of dilation/compaction bands, is also highlighted. Finally, a geophysical application to the mechanics of chevron formation shows how the proposed approach may explain the formation of natural structures. PMID:27118925

  9. How do metal ions direct ribozyme folding?

    NASA Astrophysics Data System (ADS)

    Denesyuk, Natalia A.; Thirumalai, D.

    2015-10-01

    Ribozymes, which carry out phosphoryl-transfer reactions, often require Mg2+ ions for catalytic activity. The correct folding of the active site and ribozyme tertiary structure is also regulated by metal ions in a manner that is not fully understood. Here we employ coarse-grained molecular simulations to show that individual structural elements of the group I ribozyme from the bacterium Azoarcus form spontaneously in the unfolded ribozyme even at very low Mg2+ concentrations, and are transiently stabilized by the coordination of Mg2+ ions to specific nucleotides. However, competition for scarce Mg2+ and topological constraints that arise from chain connectivity prevent the complete folding of the ribozyme. A much higher Mg2+ concentration is required for complete folding of the ribozyme and stabilization of the active site. When Mg2+ is replaced by Ca2+ the ribozyme folds, but the active site remains unstable. Our results suggest that group I ribozymes utilize the same interactions with specific metal ligands for both structural stability and chemical activity.

  10. Hydroxyapatite surface-induced peptide folding.

    PubMed

    Capriotti, Lisa A; Beebe, Thomas P; Schneider, Joel P

    2007-04-25

    Herein, we describe the design and surface-binding characterization of a de novo designed peptide, JAK1, which undergoes surface-induced folding at the hydroxyapatite (HA)-solution interface. JAK1 is designed to be unstructured in buffered saline solution, yet undergo HA-induced folding that is largely governed by the periodic positioning of gamma-carboxyglutamic acid (Gla) residues within the primary sequence of the peptide. Circular dichroism (CD) spectroscopy and analytical ultracentrifugation indicate that the peptide remains unfolded and monomeric in solution under normal physiological conditions; however, CD spectroscopy indicates that in the presence of hydroxyapatite, the peptide avidly binds to the mineral surface adopting a helical structure. Adsorption isotherms indicate nearly quantitative surface coverage and Kd = 310 nM for the peptide-surface binding event. X-ray photoelectron spectroscopy (XPS) coupled with the adsorption isotherm data suggests that JAK1 binds to HA, forming a self-limiting monolayer. This study demonstrates the feasibility of using HA surfaces to trigger the intramolecular folding of designed peptides and represents the initial stages of defining the design rules that allow HA-induced peptide folding. PMID:17397165

  11. Folded-path optical analysis gas cell

    DOEpatents

    Carangelo, R.M.; Wright, D.D.

    1995-08-08

    A folded-path gas cell employs an elliptical concave mirror in confronting relationship to two substantially spherical concave mirrors. At least one of the spherical mirrors, and usually both, are formed with an added cylindrical component to increase orthogonal foci coincidence and thereby to increase the radiation energy throughput characteristic of the cell. 10 figs.

  12. Folded cavity design for a ruby resonator

    NASA Technical Reports Server (NTRS)

    Arunkumar, K. A.; Trolinger, James D.

    1988-01-01

    A folded cavity laser resonator operating in the TEM(00) mode has been built and tested. The new oscillator configuration leads to an increase in efficiency and to better line narrowing due to the increased number of passes through the laser rod and tuning elements, respectively. The modification is shown to lead to cavity ruggedization.

  13. Fast phase randomization via two-folds

    PubMed Central

    Jeffrey, M. R.

    2016-01-01

    A two-fold is a singular point on the discontinuity surface of a piecewise-smooth vector field, at which the vector field is tangent to the discontinuity surface on both sides. If an orbit passes through an invisible two-fold (also known as a Teixeira singularity) before settling to regular periodic motion, then the phase of that motion cannot be determined from initial conditions, and, in the presence of small noise, the asymptotic phase of a large number of sample solutions is highly random. In this paper, we show how the probability distribution of the asymptotic phase depends on the global nonlinear dynamics. We also show how the phase of a smooth oscillator can be randomized by applying a simple discontinuous control law that generates an invisible two-fold. We propose that such a control law can be used to desynchronize a collection of oscillators, and that this manner of phase randomization is fast compared with existing methods (which use fixed points as phase singularities), because there is no slowing of the dynamics near a two-fold. PMID:27118901

  14. Global hairpin folding of tau in solution.

    PubMed

    Jeganathan, Sadasivam; von Bergen, Martin; Brutlach, Henrik; Steinhoff, Heinz-Jürgen; Mandelkow, Eckhard

    2006-02-21

    The microtubule-associated protein tau stabilizes microtubules in its physiological role, whereas it forms insoluble aggregates (paired helical filaments) in Alzheimer's disease. Soluble tau is considered a natively unfolded protein whose residual folding and intramolecular interactions are largely undetermined. In this study, we have applied fluorescence resonance energy transfer (FRET) and electron paramagnetic resonance (EPR) to examine the proximity and flexibility of tau domains and the global folding. FRET pairs spanning the tau molecule were created by inserting tryptophans (donor) and cysteines (labeled with IAEDANS as an acceptor) by site-directed mutagenesis. The observed FRET distances were significantly different from those expected for a random coil. Notably, the C-terminal end of tau folds over into the vicinity of the microtubule-binding repeat domain, the N-terminus remains outside the FRET distance of the repeat domain, yet both ends of the molecule approach one another. The interactions between the domains were obliterated by denaturation in GdnHCl. Paramagnetic spin-labels attached in various domains of tau were analyzed by EPR and exhibited a high mobility throughout. The data indicate that tau retains some global folding even in its "natively unfolded" state, combined with the high flexibility of the chain.

  15. Coiling and Folding of Viscoelastic Jets

    NASA Astrophysics Data System (ADS)

    Majmudar, Trushant; Varagnat, Matthieu; McKinley, Gareth

    2007-11-01

    The study of fluid jets impacting on a flat surface has industrial applications in many areas, including processing of foods and consumer goods, bottle filling, and polymer melt processing. Previous studies have focused primarily on purely viscous, Newtonian fluids, which exhibit a number of different dynamical regimes including dripping, steady jetting, folding, and steady coiling. Here we add another dimension to the problem by focusing on mobile (low viscosity) viscoelastic fluids, with the study of two wormlike-micellar fluids, a cetylpyridinum-salicylic acid salt (CPyCl/NaSal) solution, and an industrially relevant shampoo base. We investigate the effects of viscosity and elasticity on the dynamics of axi-symmetric jets. The viscoelasticity of the fluids is systematically controlled by varying the concentration of salt counterions. Experimental methods include shear and extensional rheology measurements to characterize the fluids, and high-speed digital video imaging. In addition to the regimes observed in purely viscous systems, we also find a novel regime in which the elastic jet buckles and folds on itself, and alternates between coiling and folding behavior. We suggest phase diagrams and scaling laws for the coiling and folding frequencies through a systematic exploration of the experimental parameter space (height of fall, imposed flow rate, elasticity of the solution).

  16. Self-folding graphene-polymer bilayers

    NASA Astrophysics Data System (ADS)

    Deng, Tao; Yoon, ChangKyu; Jin, Qianru; Li, Mingen; Liu, Zewen; Gracias, David H.

    2015-05-01

    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  17. Abstract folding space analysis based on helices

    PubMed Central

    Huang, Jiabin; Backofen, Rolf; Voß, Björn

    2012-01-01

    RNA has many pivotal functions especially in the regulation of gene expression by ncRNAs. Identification of their structure is an important requirement for understanding their function. Structure prediction alone is often insufficient for this task, due to algorithmic problems, parameter inaccuracies, and biological peculiarities. Among the latter, there are base modifications, cotranscriptional folding leading to folding traps, and conformational switching as in the case of riboswitches. All these require more in-depth analysis of the folding space. The major drawback, which all methods have to cope with, is the exponential growth of the folding space. Therefore, methods are often limited in the sequence length they can analyze, or they make use of heuristics, sampling, or abstraction. Our approach adopts the abstraction strategy and remedies some problems of existing methods. We introduce a position-specific abstraction based on helices that we term helix index shapes, or hishapes for short. Utilizing a dynamic programming framework, we have implemented this abstraction in the program RNAHeliCes. Furthermore, we developed two hishape-based methods, one for energy barrier estimation, called HiPath, and one for abstract structure comparison, termed HiTed. We demonstrate the superior performance of HiPath compared to other existing methods and the competitive accuracy of HiTed. RNAHeliCes, together with HiPath and HiTed, are available for download at http://www.cyanolab.de/software/RNAHeliCes.htm. PMID:23104999

  18. Self-folding graphene-polymer bilayers

    SciTech Connect

    Deng, Tao; Yoon, ChangKyu; Jin, Qianru; Li, Mingen; Liu, Zewen; Gracias, David H.

    2015-05-18

    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  19. Description and classification of folds in single surfaces

    NASA Astrophysics Data System (ADS)

    Twiss, Robert J.

    I propose a new three-parameter description of fold style in folded surfaces based on the ratio of the amplitude to the half-wavelength (the aspect ratio P), the maximum angle of relative rotation of opposite limbs of the fold (the folding angle φ), and a measure of the relative curvature at the fold closure (the bluntness b). For symmetric folds, the first two parameters define a trapezoid that circumscribes the fold and provides the primary criterion for the classification of fold style. Within a given trapezoid, fold style variations are defined by the bluntness. Perfect folds in profile are defined to have a single hinge with perfectly straight limbs tangent to hinge zones that are perfect circular arcs. An analytic description of the variation in perfect fold geometry defines the limits for all natural single-hinged folds. The proposed system includes folds with folding angles both less than and greater than isoclinal folds, it applies to both single-hinged and multiple-hinged folds, and it also can be extended to apply to asymmetric folds. Previously proposed two-parameter classification systems can only describe folds that are restricted to a specific surface through the three-parameter fold style space proposed here.

  20. Fault-related folding during extension: Plunging basement-cored folds in the Basin and Range

    USGS Publications Warehouse

    Howard, K.A.; John, Barbara E.

    1997-01-01

    Folds are able to form in highly extended areas where stratified cover rocks respond to basement fault offsets. The response of cover rocks to basement faulting can be studied especially well in plunging structures that expose large structural relief. The southern Basin and Range province contains plunging folds kilometres in amplitude at the corners of domino-like tilt blocks of basement rocks, where initially steep transverse and normal faults propagated upward toward the layered cover rocks. Exposed tilted cross sections, as much as 8 km thick, display transitions from faulted basement to folded cover that validate laboratory models of forced folds. The folded cover masks a deeper extensional style of brittle segmentation and uniform steep tilting.

  1. Oxidative folding of peptides with cystine-knot architectures: kinetic studies and optimization of folding conditions.

    PubMed

    Reinwarth, Michael; Glotzbach, Bernhard; Tomaszowski, Michael; Fabritz, Sebastian; Avrutina, Olga; Kolmar, Harald

    2013-01-01

    Bioactive peptides often contain several disulfide bonds that provide the main contribution to conformational rigidity and structural, thermal, or biological stability. Among them, cystine-knot peptides-commonly named "knottins"-make up a subclass with several thousand natural members. Hence, they are considered promising frameworks for peptide-based pharmaceuticals. Although cystine-knot peptides are available through chemical and recombinant synthetic routes, oxidative folding to afford the bioactive isomers still remains a crucial step. We therefore investigated the oxidative folding of ten protease-inhibiting peptides from two knottin families, as well as that of an HIV entry inhibitor and of aprotinin, under two conventional sets of folding conditions and by a newly developed procedure. Kinetic studies identified folding conditions that resulted in correctly folded miniproteins with high rates of conversion even for highly hydrophobic and aggregation-prone peptides in concentrated solutions. PMID:23229141

  2. Generation of buckle folds in Naga fold thrust belt, north-east India

    NASA Astrophysics Data System (ADS)

    Saha, B.; Dietl, C.

    2009-04-01

    Naga fold thrust belt (NFTB), India, formed as a result of northward migration of the Indian plate initiated in Eocene and its subsequent collision with the Burmese plate during Oligocene. The NW-SE oriented compression generated a spectrum of structures; among them, we intend to focus on the folds- varying from gentle to tight asymmetric in geometry. Large recumbent folds are often associated with thrusting. Buckle folds forming under shallow crustal conditions are frequently reported from NFTB. Buckle folding occurs mainly within sandstones with intercalated shale layers which are in the study area typical for the Barail, Surma and Tipam Groups. We have tried to explain the controlling factors behind the variation of the buckle fold shapes and their varying wavelengths throughout the fold thrust belt with the aid of analogue (sand box) modelling. It is undoubted that competence contrast along with the layer parallel compressive stress are the major influencing factors in generation of buckle folds. Schmalholz and Podladchikov (1999) and Jeng et al. (2002) have shown that when low strain rate and low temperature are applicable, not only the viscosity contrast, but also the elasticity contrast govern the geometry of the developing buckle folds. Rocks deforming under high temperature and high pressure deform in pure viscous manner, whereas, rocks undergoing less confining stress and less temperature, are subjected to pure elastic deformation. However, they are the end members, and most of the deformations are a combination of these two end members, i.e. of viscoelastic nature. Our models are made up of sieved sand (0.5 mm grain size) and mica layers (1-5 mm) This interlayering imparts a mechanical anisotropy in the model. Mica is not a pure viscous material, rather it displays more elastic behaviour. The mica layers in the model produce bedding parallel slip during shortening through internal reorganization of the individual mica crystals leading to the thickening

  3. Advancing Successful Physics Majors - The Physics First Year Seminar Experience

    NASA Astrophysics Data System (ADS)

    Deibel, Jason; Petkie, Douglas

    In 2012, the Wright State University physics curriculum introduced a new year-long seminar course required for all new physics majors. The goal of this course is to improve student retention and success via building a community of physics majors and provide them with the skills, mindset, and advising necessary to successfully complete a degree and transition to the next part of their careers. This new course sequence assembles a new cohort of majors annually. To prepare each cohort, students engage in a variety of activities that span from student success skills to more specific physics content while building an entrepreneurial mindset. Students participate in activities including study skills, career night, course planning, campus services, and a department social function. More importantly, students gain exposure to programming, literature searches, data analysis, technical writing, elevator pitches, and experimental design via hands-on projects. This includes the students proposing, designing, and conducting their own experiments. Preliminary evidence indicates increased retention, student success, and an enhanced sense of community among physics undergraduate students, The overall number of majors and students eventually completing their physics degrees has nearly tripled. Associate Professor, Department of Physics.

  4. Riddle of light: a seminar course for scientists and humanists

    NASA Astrophysics Data System (ADS)

    Stoicheff, Boris P.

    2000-06-01

    Recently a new program of `First Year Seminar Courses' was initiated in the Faculty of Arts and Science at the University of Toronto to introduce in-coming undergraduates to the excitement of university scholarship. These are full- year elective courses, and in each course students work closely with a faculty member in groups of no more than 20 students. I shall review my experiences in these past three years in organizing a course on light, optics, and photonics. The primary aim was to use the rich story of light to bring together students of a variety of intellectual interests, in the hope of demonstrating the valuable knowledge that the cultures of the humanists and scientists can bring to an understanding of the modern world. As we are all aware, the story of light is so all- embracing that this course included not only the science of light and optics, with lasers and photonics, but light in the open air, astronomy, religion, literature, art, architecture, film, stage, health and medicine, with several of the topics discussed by guest speakers. After a brief review of the story of light from its earliest beginnings, an outline of the course will be given along with the many contributions by the students and evaluation of their efforts.

  5. Proceedings of the joint Russian-American hydrogeology seminar

    SciTech Connect

    Tsang, C.F.; Mironenko, V.; Pozdniakov, S.

    1997-12-31

    Hydrogeology research has been very active in both Russia and the US because of the concerns for migration of radioactive and chemical contaminants in soils and geologic formations, as well as for water problems related to mining and other industrial operations. Russian hydrogeologists have developed various analysis and field testing techniques, sometimes in parallel with US counterparts. These Proceedings come out of a Seminar held to bring together a small group (about 15) of active Russian researchers in geologic flow and transport associated with the disposal of radioactive and chemical wastes either on the soils or through deep injection wells, with a corresponding group (about 25) of American hydrogeologists. The meeting was intentionally kept small to enable informal, detailed and in-depth discussions on hydrogeological issues of common interest. Out of this interaction, the authors hope that, firstly, they will have learned from each other and secondly, that research collaborations will be established where there is the opportunity. This proceedings presents the summaries and viewgraphs from the presentations. What cannot be conveyed here is the warm and cooperative atmosphere of these interactions, both inside and outside the formal sessions, which may well lead to future collaborations.

  6. A Graduate Seminar on Science, Public Policy, and Outreach

    NASA Astrophysics Data System (ADS)

    Rahman, A. F.

    2006-12-01

    I offered a seminar course titled, `Science, Public Policy and Outreach' for graduate students of the College of Agricultural and Natural Resources (CASNR) at Texas Tech University. The underlying theme of the course was that today's graduate students in the natural resource management disciplines should be familiar with public policy and public outreach processes in order to be successful professionals of tomorrow. In US system of government, scientific knowledge about an environmental problem does not have much practical impact without a corresponding legislation aimed at solving that problem. Elected officials feel pressure to legislate laws only if their constituents have a strong opinion in favor of solving that problem. Constituents tend to have strong opinion on things that are frequently mentioned in the media. Hence, public policy, outreach through media, and scientific explorations are intertwined in the US system. I invited state and national level policy makers, lobbyists, and radio and television personnel to present their perspectives on this issue and to discuss the roles and potentials for scientists in public policy and outreach processes. Students were divided into groups at the start of the semester. Each group focused on a current resource management topic, researched the policy and outreach issues related to their topic, wrote a well organized essay, and finally made a group presentation of the case study at the end of the semester. I shall present the experience of the class and outcomes of that course in this presentation, with future directions and suggestions for others who are interested to offer similar courses.

  7. A seminar on gardens for the health of the skin.

    PubMed

    Ryan, Terence J; Matts, Paul J; Snyder, Brad; Orr, Vanya

    2014-05-01

    This is a report on a seminar held on January 12, 2013, at the Regional Dermatology Training Centre in Tanzania, sponsored by the International Society of Dermatology as part of its Taskforce Program for Skin Care for All: Community Dermatology. There were four themes: (i) Gardens attached to health centers increase their attractiveness and result in increased attendance and, thus, increase the utilization of effective skin care interventions. Literature on the positive effect of greenery surrounding health centers on health and the environment is reviewed. (ii) Adding an expert on agriculture to the staff of health centers in Rwanda has provided nutrition and safe medicines. (iii) In southern India, these interventions are channeled through the empowerment of tribal women in an area noted for anxiety due to unemployment in the tea and forestry industry. The gardens are used for teaching about nutrition and herbal medicines, and the women are further attracted by childcare facilities. (iv) Measuring barrier function defects gives early warning of malnutrition of the skin after damage by trauma or by ultraviolet radiation. Higher cost research techniques may help to provide the science required to produce its evidence base. In conclusion, Gardens for health should be adopted as policy by skin care providers.

  8. Discipline-Based Art Education and Cultural Diversity. Seminar Proceedings of a National Invitational Seminar (3rd, Austin Texas, August 6-9, 1992).

    ERIC Educational Resources Information Center

    Getty Center for Education in the Arts, Los Angeles, CA.

    This publication contains proceedings of a seminar structured around five basic themes: (1) cultural diversity in education; (2) discipline based art education (DBAE) and cultural diversity; (3) how cultural diversity has affected practices in art history, aesthetics, criticism, and art making; (4) experiences in other disciplines which effect…

  9. Creativity in English: Papers Relating to the Anglo-American Seminar on the Teaching of English (Dartmouth College, New Hampshire, 1966). The Dartmouth Seminar Papers.

    ERIC Educational Resources Information Center

    Summerfield, Geoffrey, Ed.

    Creativity and its development in students through creative English programs are the subjects of this report from the Dartmouth Seminar. David Holbrook's paper, "Creativity in the English Programme," maintains that English should be taught creatively to enhance the child's capacity to deal with his inner and outer experiences and to help him grow…

  10. The Story of a Seminar in Applied Communication. The Dag Hammarskjold Seminar on "Communication--An Essential Component in Development Work" (Uppsala, Sweden, August 27-September 9, 1972).

    ERIC Educational Resources Information Center

    Fuglesang, Andreas, Ed.

    The objective of the two week long 1972 Dag Hammarskjold Seminar was to break away from traditional and theoretical concepts of information work in order to gain a practical insight into communication, especially as it applies to social and economic development. Fifty participants and lecturers from developed and developing countries in Europe and…

  11. Adaptation of Rural and Foreign Workers to Industry, International Joint Seminar (Wiesbaden, December 10-13, 1963). Final Report. International Seminars 1963-4.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France). Social Affairs Div.

    The major purpose of a seminar held in Wiesbaden, Germany, was to exchange experiences and views on the methods of expediating adjustment of rural and foreign workers to industry. Major presentations for discussion were "Internal Migration" by Magda Talamo, and "International Migration" by Elie Dimitras. Some conclusions were: (1) Movement of the…

  12. Changes & Challenges: Hot Topics in a New Era of Schools. Proceedings of the Education Law Association Winter Seminar (Park City, UT, March 15-18, 2001). Seminar Outlines.

    ERIC Educational Resources Information Center

    Education Law Association, Dayton, OH.

    The following are outlines presented by individuals at the Education Law Association 2001 winter seminar: "Academic Freedom and the Religiously Affiliated University" (the freedom to teach, research, and publish has never been--and still is not--without limits); "How Random and Suspicionless May School Searches Be" (random and suspicionless drug…

  13. Proceedings of the Towards Competency Seminar. A Seminar on Curriculum Development and Evaluation in Vocational Education in New Zealand (Wellington, New Zealand, August 30-31, 1988).

    ERIC Educational Resources Information Center

    Wagner, Graham, Ed.

    These proceedings begin with opening remarks that discuss seminar concerns and objectives. These remarks define two concerns: (1) evaluation of the methods of curriculum development and evaluation appropriate for vocational education in New Zealand; and (2) development of guidelines to assist educators to meet the requirements for competency-based…

  14. THE USES OF MYTH, PAPERS RELATING TO THE ANGLO-AMERICAN SEMINAR ON THE TEACHING OF ENGLISH (DARTMOUTH COLLEGE, NEW HAMPSHIRE, 1966). THE DARTMOUTH SEMINAR PAPERS.

    ERIC Educational Resources Information Center

    OLSON, PAUL A., ED.

    THE USES OF MYTH, ITS RELATION TO TRANSLATION, AND THE RELATION OF BOTH TO THE TEACHING OF ENGLISH FORM THE SUBJECTS OF THIS DARTMOUTH SEMINAR STUDY-GROUP REPORT. PAUL OLSON'S INTRODUCTION ON THE BASIC ISSUES OF DEFINITION AND SYSTEMATIC INTERPRETATION IS FOLLOWED BY THE POSITION PAPER, "SOME MEANINGS AND USES OF MYTH" BY ALBERT LAVIN, WHICH…

  15. Microfluidic Mixers for Studying Protein Folding

    PubMed Central

    Waldauer, Steven A.; Wu, Ling; Yao, Shuhuai; Bakajin, Olgica; Lapidus, Lisa J.

    2012-01-01

    The process by which a protein folds into its native conformation is highly relevant to biology and human health yet still poorly understood. One reason for this is that folding takes place over a wide range of timescales, from nanoseconds to seconds or longer, depending on the protein1. Conventional stopped-flow mixers have allowed measurement of folding kinetics starting at about 1 ms. We have recently developed a microfluidic mixer that dilutes denaturant ~100-fold in ~8 μs2. Unlike a stopped-flow mixer, this mixer operates in the laminar flow regime in which turbulence does not occur. The absence of turbulence allows precise numeric simulation of all flows within the mixer with excellent agreement to experiment3-4. Laminar flow is achieved for Reynolds numbers Re ≤100. For aqueous solutions, this requires micron scale geometries. We use a hard substrate, such as silicon or fused silica, to make channels 5-10 μm wide and 10 μm deep (See Figure 1). The smallest dimensions, at the entrance to the mixing region, are on the order of 1 μm in size. The chip is sealed with a thin glass or fused silica coverslip for optical access. Typical total linear flow rates are ~1 m/s, yielding Re~10, but the protein consumption is only ~0.5 nL/s or 1.8 μL/hr. Protein concentration depends on the detection method: For tryptophan fluorescence the typical concentration is 100 μM (for 1 Trp/protein) and for FRET the typical concentration is ~100 nM. The folding process is initiated by rapid dilution of denaturant from 6 M to 0.06 M guanidine hydrochloride. The protein in high denaturant flows down a central channel and is met on either side at the mixing region by buffer without denaturant moving ~100 times faster (see Figure 2). This geometry causes rapid constriction of the protein flow into a narrow jet ~100 nm wide. Diffusion of the light denaturant molecules is very rapid, while diffusion of the heavy protein molecules is much slower, diffusing less than 1 μm in 1 ms

  16. Start2Fold: a database of hydrogen/deuterium exchange data on protein folding and stability

    PubMed Central

    Pancsa, Rita; Varadi, Mihaly; Tompa, Peter; Vranken, Wim F.

    2016-01-01

    Proteins fulfil a wide range of tasks in cells; understanding how they fold into complex three-dimensional (3D) structures and how these structures remain stable while retaining sufficient dynamics for functionality is essential for the interpretation of overall protein behaviour. Since the 1950's, solvent exchange-based methods have been the most powerful experimental means to obtain information on the folding and stability of proteins. Considerable expertise and care were required to obtain the resulting datasets, which, despite their importance and intrinsic value, have never been collected, curated and classified. Start2Fold is an openly accessible database (http://start2fold.eu) of carefully curated hydrogen/deuterium exchange (HDX) data extracted from the literature that is open for new submissions from the community. The database entries contain (i) information on the proteins investigated and the underlying experimental procedures and (ii) the classification of the residues based on their exchange protection levels, also allowing for the instant visualization of the relevant residue groups on the 3D structures of the corresponding proteins. By providing a clear hierarchical framework for the easy sharing, comparison and (re-)interpretation of HDX data, Start2Fold intends to promote a better understanding of how the protein sequence encodes folding and structure as well as the development of new computational methods predicting protein folding and stability. PMID:26582925

  17. Vocal fold and ventricular fold vibration in period-doubling phonation: physiological description and aerodynamic modeling.

    PubMed

    Bailly, Lucie; Henrich, Nathalie; Pelorson, Xavier

    2010-05-01

    Occurrences of period-doubling are found in human phonation, in particular for pathological and some singing phonations such as Sardinian A Tenore Bassu vocal performance. The combined vibration of the vocal folds and the ventricular folds has been observed during the production of such low pitch bass-type sound. The present study aims to characterize the physiological correlates of this acoustical production and to provide a better understanding of the physical interaction between ventricular fold vibration and vocal fold self-sustained oscillation. The vibratory properties of the vocal folds and the ventricular folds during phonation produced by a professional singer are analyzed by means of acoustical and electroglottographic signals and by synchronized glottal images obtained by high-speed cinematography. The periodic variation in glottal cycle duration and the effect of ventricular fold closing on glottal closing time are demonstrated. Using the detected glottal and ventricular areas, the aerodynamic behavior of the laryngeal system is simulated using a simplified physical modeling previously validated in vitro using a larynx replica. An estimate of the ventricular aperture extracted from the in vivo data allows a theoretical prediction of the glottal aperture. The in vivo measurements of the glottal aperture are then compared to the simulated estimations. PMID:21117769

  18. PREFACE Protein folding: lessons learned and new frontiers Protein folding: lessons learned and new frontiers

    NASA Astrophysics Data System (ADS)

    Pappu, Rohit V.; Nussinov, Ruth

    2009-03-01

    In appropriate physiological milieux proteins spontaneously fold into their functional three-dimensional structures. The amino acid sequences of functional proteins contain all the information necessary to specify the folds. This remarkable observation has spawned research aimed at answering two major questions. (1) Of all the conceivable structures that a protein can adopt, why is the ensemble of native-like structures the most favorable? (2) What are the paths by which proteins manage to robustly and reproducibly fold into their native structures? Anfinsen's thermodynamic hypothesis has guided the pursuit of answers to the first question whereas Levinthal's paradox has influenced the development of models for protein folding dynamics. Decades of work have led to significant advances in the folding problem. Mean-field models have been developed to capture our current, coarse grain understanding of the driving forces for protein folding. These models are being used to predict three-dimensional protein structures from sequence and stability profiles as a function of thermodynamic and chemical perturbations. Impressive strides have also been made in the field of protein design, also known as the inverse folding problem, thereby testing our understanding of the determinants of the fold specificities of different sequences. Early work on protein folding pathways focused on the specific sequence of events that could lead to a simplification of the search process. However, unifying principles proved to be elusive. Proteins that show reversible two-state folding-unfolding transitions turned out to be a gift of natural selection. Focusing on these simple systems helped researchers to uncover general principles regarding the origins of cooperativity in protein folding thermodynamics and kinetics. On the theoretical front, concepts borrowed from polymer physics and the physics of spin glasses led to the development of a framework based on energy landscape theories. These

  19. Folded membrane dialyzer with mechanically sealed edges

    DOEpatents

    Markley, Finley W.

    1976-01-01

    A semipermeable membrane is folded in accordion fashion to form a stack of pleats and the edges are sealed so as to isolate the opposite surfaces of the membrane. The stack is contained within a case that provides ports for flow of blood in contact with one surface of the membrane through channels formed by the pleats and also provides ports for flow of a dialysate through channels formed by the pleats in contact with the other surface of the membrane. The serpentine side edges of the membrane are sealed by a solidified plastic material, whereas effective mechanical means are provided to seal the end edges of the folded membrane. The mechanical means include a clamping strip which biases case sealing flanges into a sealed relationship with end portions of the membrane near the end edges, which portions extend from the stack and between the sealing flanges.

  20. Chevron folding patterns and heteroclinic orbits

    NASA Astrophysics Data System (ADS)

    Budd, Christopher J.; Chakhchoukh, Amine N.; Dodwell, Timothy J.; Kuske, Rachel

    2016-09-01

    We present a model of multilayer folding in which layers with bending stiffness EI are separated by a very stiff elastic medium of elasticity k2 and subject to a horizontal load P. By using a dynamical system analysis of the resulting fourth order equation, we show that as the end shortening per unit length E is increased, then if k2 is large there is a smooth transition from small amplitude sinusoidal solutions at moderate values of P to larger amplitude chevron folds, with straight limbs separated by regions of high curvature when P is large. The chevron solutions take the form of near heteroclinic connections in the phase-plane. By means of this analysis, values for P and the slope of the limbs are calculated in terms of E and k2.