75 FR 38792 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

... inquiries to the 45 Space Wing Command Post, Patrick Air Force Base, FL 32925-3002. Requests must contain... Superintendent, 30 Space Wing Command Post 867 Washington Ave, Suite 205, Vandenberg Air Force Base, CA 93437... inquiries to 45 Space Wing Command Post, Patrick Air Force Base, FL 32925-3002. Requests must contain the...

78 FR 5791 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... of records should address written inquiries to the 45 Space Wing Command Post, Patrick Air Force Base... Superintendent, 30 Space Wing Command Post, 867 Washington Ave., Suite 205, Vandenberg Air Force Base, CA 93437... written inquiries to 45th Space Wing Command Post, Patrick Air Force Base, FL 32925-3002. Individuals with...

Defense Threat Reduction Agency > About > Locations

Science.gov Websites

Air Force Base, Ca. Mercury, Nev. Albuquerque, N.M. White Sands Missile Range, N.M. Omaha, Neb . (USSTRATCOM) Eglin Air Force Base, Fla. National Capital Region Georgia Azerbaijan Armenia Japan Republic of , Md. Eglin Air Force Base, Fla. Albuquerque, N.M. White Sands Missile Range, N.M. Mercury, Nev. Travis

2. GENERAL VIEW OF SLC3 AIR FORCE BUILDING (BLDG. 761) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. GENERAL VIEW OF SLC-3 AIR FORCE BUILDING (BLDG. 761) FROM THE NORTHWEST - Vandenberg Air Force Base, Space Launch Complex 3, SLC-3 Air Force Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

1. GENERAL VIEW OF SLC3 AIR FORCE BUILDING (BLDG. 761) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF SLC-3 AIR FORCE BUILDING (BLDG. 761) FROM THE SOUTHWEST - Vandenberg Air Force Base, Space Launch Complex 3, SLC-3 Air Force Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

2. DETAIL, CONDUITS ALONG BASE OF NORTH FRONT. Looking east. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. DETAIL, CONDUITS ALONG BASE OF NORTH FRONT. Looking east. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-4, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

SOUTHEAST AND NORTHEAST SIDES. Looking west Edwards Air Force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHEAST AND NORTHEAST SIDES. Looking west - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Fuel & Water Tank, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Beale Air Force Base, Perimeter Acquisition Vehicle Entry PhasedArray Warning ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Beale Air Force Base, Perimeter Acquisition Vehicle Entry Phased-Array Warning System, Satellite Communications Terminal, End of Spencer Paul Road, north of Warren Shingle Road (14th Street), Marysville, Yuba County, CA

Beale Air Force Base, Perimeter Acquisition Vehicle Entry PhasedArray Warning ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Beale Air Force Base, Perimeter Acquisition Vehicle Entry Phased-Array Warning System, Electric Substation, End of Spencer Paul Road, north of Warren Shingle Road (14th Street), Marysville, Yuba County, CA

Looking north Beale Air Force Base, Perimeter Acquisition Vehicle ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking north - Beale Air Force Base, Perimeter Acquisition Vehicle Entry Phased-Array Warning System, Electric Substation, End of Spencer Paul Road, north of Warren Shingle Road (14th Street), Marysville, Yuba County, CA

Building 904, oblique view to southeast, 135 mm lens. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 904, oblique view to southeast, 135 mm lens. - Travis Air Force Base, Base Spares Warehouse No. 1, Dixon Avenue & W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

Building 904, oblique view to northwest, 135 mm lens ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 904, oblique view to northwest, 135 mm lens - Travis Air Force Base, Base Spares Warehouse No. 1, Dixon Avenue & W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

Beale Air Force Base, Perimeter Acquisition Vehicle Entry PhasedArray Warning ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Beale Air Force Base, Perimeter Acquisition Vehicle Entry Phased-Array Warning System, Microwave Equipment Building, End of Spencer Paul Road, north of Warren Shingle Road (14th Street), Marysville, Yuba County, CA

1. Credit USAF, ca. 1942. Original housed in the Muroc ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Credit USAF, ca. 1942. Original housed in the Muroc Flight Test Base, Unit History, 1 September 1942 - 30 June 1945. Alfred F. Simpson Historical Research Agency. United States Air Force. Maxwell AFB, Alabama. Historical view looks west southwest at construction of Building 4317, Deluge Water Pumping Station (then designated Pump House No. 3). This in-ground structure houses fire pumps which draw water from an in-ground reservoir, Building 4316 (See HAER photos CA-170-I). Pumping station was built in-ground to take advantage of gravity, since water flows from reservoir to prime the pumps, and fire system piping is underground. Opening in far wall is to stairs leading up to ground level. Earth mound in background is part of water reservoir construction (Building 4316). - Edwards Air Force Base, North Base, Deluge Water Pumping Station, Near Second & D Streets, Boron, Kern County, CA

Vector Analysis of Ionic Collision on CaCO3 Precipitation Based on Vibration Time History

NASA Astrophysics Data System (ADS)

Mangestiyono, W.; Muryanto, S.; Jamari, J.; Bayuseno, A. P.

2017-05-01

Vibration effects on the piping system can result from the internal factor of fluid or the external factor of the mechanical equipment operation. As the pipe vibrated, the precipitation process of CaCO3 on the inner pipe could be affected. In the previous research, the effect of vibration on CaCO3 precipitation in piping system was clearly verified. This increased the deposition rate and decreased the induction time. However, the mechanism of vibration control in CaCO3 precipitation process as the presence of vibration has not been recognized yet. In the present research, the mechanism of vibration affecting the CaCO3 precipitation was investigated through vector analysis of ionic collision. The ionic vector force was calculated based on the amount of the activation energy and the vibration force was calculated based on the vibration sensor data. The vector resultant of ionic collision based on the vibration time history was analyzed to prove that vibration brings ionic collision randomly to the planar horizontal direction and its collision model was suspected as the cause of the increasing deposition rate.

Beale Air Force Base, Perimeter Acquisition Vehicle Entry PhasedArray Warning ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Beale Air Force Base, Perimeter Acquisition Vehicle Entry Phased-Array Warning System, Civil Engineering Storage Building, End of Spencer Paul Road, north of Warren Shingle Road (14th Street), Marysville, Yuba County, CA

Interior, looking northeast Beale Air Force Base, Perimeter Acquisition ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior, looking northeast - Beale Air Force Base, Perimeter Acquisition Vehicle Entry Phased-Array Warning System, Microwave Equipment Building, End of Spencer Paul Road, north of Warren Shingle Road (14th Street), Marysville, Yuba County, CA

4. BUILDING 8767, INTERIOR. Looking west. Edwards Air Force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. BUILDING 8767, INTERIOR. Looking west. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

DETAIL, CONTROL BOOTH, RP1 TANK FARM Edwards Air Force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL, CONTROL BOOTH, RP1 TANK FARM - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Combined Fuel Storage Tank Farm, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

13. Photocopy of photograph (original photograph in possession of 30th ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of photograph (original photograph in possession of 30th Audiovisual Squadron, Vandenberg Air Force Base, California). Photography by United States Air Force, date unknown. THRUST AUGMENTED THOR PREPARED FOR LAUNCH FROM SLC-3W. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

23. Photographic copy of an asconstructed site plan for North ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Photographic copy of an as-constructed site plan for North Base: Air Force Flight Test Center, Edwards Air Force Base, Edwards, California: North Base Site Plan, February 1970. This drawing shows the North Base building distribution substantially as it appears in 1995. Records on file at AFFTC/CE-CECC-B (Design/Construction Flight/RPMC), Edwards AFB, California. - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

1. BUILDING 8698, TEST STAND 13, WEST ELEVATION. NOTE TUNNEL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. BUILDING 8698, TEST STAND 1-3, WEST ELEVATION. NOTE TUNNEL BETWEEN BLDG. 8668 AND TEST STAND 1-3. TEST AREA 1-120 IN THE MIDDLE DISTANCE, AND TEST AREA 1-125 ON THE HORIZON. Looking northeast from the roof of Building 8668, Instrumentation and Control Center. Note: Photograph CA-236-F-2 is an 8" x 10" enlargement from a 4" x 5" negative. This view is a photocopy of a recent resin coated print made from a print held at the Main Base History Office, Edwards Air Force Base, California. Photographer unknown. Date and file number unknown. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-3, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

View looks northeast (44°) across concrete foundation for Second Street ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View looks northeast (44°) across concrete foundation for Second Street Mess Hall. See HAER photo CA-170-Q-3 for view of Mess Hall building - Edwards Air Force Base, North Base, Second Street Mess Hall T-10, Second Street, Boron, Kern County, CA

12. Photocopy of photograph (original photograph in possession of 30th ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of photograph (original photograph in possession of 30th Audiovisual Squadron, Vandenberg Air Force Base, California). Photography by United States Air Force, date unknown. LAUNCH OF AN ATLAS FROM SLC-3. MOBILE SERVICE TOWER (MST) IN PARKED POSITION. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Predominant cause of prolonged low-frequency force depression changes during recovery after in situ fatiguing stimulation of rat fast-twitch muscle.

PubMed

Watanabe, Daiki; Wada, Masanobu

2016-11-01

To investigate time-dependent changes in sarcoplasmic reticulum (SR) Ca 2+ release and myofibrillar (my-) Ca 2+ sensitivity during recovery from prolonged low-frequency force depression (PLFFD), rat gastrocnemius muscles were electrically stimulated in situ. After 0 h (R0), 0.5 h (R0.5), 2 h (R2), 6 h (R6), or 12 h of recovery, the superficial gastrocnemius muscles were excised and used for biochemical and skinned fiber analyses. At R0, R0.5, R2, and R6, the ratio of force at 1 Hz to that at 50 Hz was decreased in the skinned fibers. The ratio of depolarization-induced force to the maximum Ca 2+ -activated force (depol/Ca 2+ force ratio) was utilized as an indicator of SR Ca 2+ release. At R0, both the depol/Ca 2+ force ratio and my-Ca 2+ sensitivity were decreased. At R0.5 and R2, my-Ca 2+ sensitivity was recovered, while the depol/Ca 2+ force ratio remained depressed. At R6, my-Ca 2+ sensitivity was decreased again, whereas the depol/Ca 2+ force ratio was nearly restored. Western blot analyses demonstrated that decreased my-Ca 2+ sensitivity at R6 and reduced depol/Ca 2+ force ratio at R0, R0.5, and R2 were accompanied by depressions in S-glutathionylated troponin I and increases in dephosphorylated ryanodine receptor 1, respectively. These results indicate that, in the early stage of recovery, reduced SR Ca 2+ release plays a primary role in the etiology of PLFFD, whereas decreased my-Ca 2+ sensitivity is involved in the late stage, and suggest that S-glutathionylation of troponin I and dephosphorylation of ryanodine receptor 1 contribute, at least partly, to fatiguing contraction-induced alterations in my-Ca 2+ sensitivity and SR Ca 2+ release, respectively. Copyright © 2016 the American Physiological Society.

The Civil-Military Gap in the United States. Does It Exist, Why, and Does It Matter?

DTIC Science & Technology

2007-01-01

and/or the general public. Based on this framework, our analysis then compares the char- acteristics of military and civilian respondents using a...armed forces, three major force structure reviews (1990 Base Force, 1993 Bottom-Up Review, 1997 Quadrennial Defense Review) took place in the space...Defense Planning in a Decade of Change: Lessons from the Base Force, Bottom-Up Review, and Quadrennial Defense Review, Santa Monica, CA: RAND

Abandoning the Battleship: The Asymmetric Ground Defense of Air Power

DTIC Science & Technology

2009-04-01

Force became a separate service in 1947 in what could be considered a “nasty divorce .” The joint service agreement between the air and ground...15 Ditlevson, Jeffery T. “Air Base Defense: Different Times Call for Different Methods.” Monterrey , CA: Naval Postgraduate... Monterrey , CA: Naval Postgraduate School, December 2006. Douhet, Guilio. The Command of the Air. Washington, D.C.: U.S. Air Force Office of

Final Environmental Assessment for Low-Level Flight Testing, Evaluation, and Training, Edwards Air Force Base

DTIC Science & Technology

2005-05-01

4. TITLE AND SUBTITLE Final Environmental Assessment for Low-Level Flight Testing, Evaluation, and Training, Edwards Air Force Base 5a. CONTRACT...NAME(S) AND ADDRESS(ES) Air Force Flight Test Center,Environmental Management Directorate,Edwards AFB,CA,93524 8. PERFORMING ORGANIZATION REPORT...DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The U.S. Air Force Flight Test

19. DETAIL OF AIR FORCE WEATHER INFORMATION TERMINAL AND CHART ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. DETAIL OF AIR FORCE WEATHER INFORMATION TERMINAL AND CHART RECORDER LOCATED IMMEDIATELY NORTH OF CONSOLE IN PHOTOS A-15 THROUGH A-18. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Developmental changes in the activation properties and ultrastructure of fast- and slow-twitch muscles from fetal sheep.

PubMed

West, J M; Barclay, C J; Luff, A R; Walker, D W

1999-04-01

At early stages of muscle development, skeletal muscles contract and relax slowly, regardless of whether they are destined to become fast- or slow-twitch. In this study, we have characterised the activation profiles of developing fast- and slow-twitch muscles from a precocial species, the sheep, to determine if the activation profiles of the muscles are characteristically slow when both the fast- and slow-twitch muscles have slow isometric contraction profiles. Single skinned muscle fibres from the fast-twitch flexor digitorum longus (FDL) and slow-twitch soleus muscles from fetal (gestational ages 70, 90, 120 and 140 days; term 147 days) and neonatal (8 weeks old) sheep were used to determine the isometric force-pCa (pCa = -log10[Ca2+]) and force-pSr relations during development. Fast-twitch mammalian muscles generally have a greatly different sensitivity to Ca2+ and Sr2+ whereas slow-twitch muscles have a similar sensitivity to these divalent cations. At all ages studied, the force-pCa and force-pSr relations of the FDL muscle were widely separated. The mean separation of the mid-point of the curves (pCa50-pSr50) was approximately 1.1. This is typical of adult fast-twitch muscle. The force-pCa and force-pSr curves for soleus muscle were also widely separated at 70 and 90 days gestation (pCa50-pSr50 approximately 0.75); between 90 days and 140 days this separation decreased significantly to approximately 0.2. This leads to a paradoxical situation whereby at early stages of muscle development the fast muscles have contraction dynamics of slow muscles but the slow muscles have activation profiles more characteristic of fast muscles. The time course for development of the FDL and soleus is different, based on sarcomere structure with the soleus muscle developing clearly defined sarcomere structure earlier in gestation than the FDL. At 70 days gestation the FDL muscle had no clearly defined sarcomeres. Force (N cm-2) increased almost linearly between 70 and 140 days gestation in both muscle types and there was no difference between the Ca(2+)- and Sr(2+)-activated force throughout development.

SOUTH FRONT AND EAST SIDE. January, 1998 Edwards Air ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTH FRONT AND EAST SIDE. January, 1998 - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Electrical Substation, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

2. CONTROL ROOM INTERIOR, CONSOLE AND MONITORS. Looking west. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. CONTROL ROOM INTERIOR, CONSOLE AND MONITORS. Looking west. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

Building 931, oblique view to northwest, 210 mm lens. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 931, oblique view to northwest, 210 mm lens. - Travis Air Force Base, Central Battery Charging Building, North of W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

Building 1204, oblique view to east, 90 mm lens. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 1204, oblique view to east, 90 mm lens. - Travis Air Force Base, Squadron Operations & Readiness Crew Facility, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

Building 1204, oblique view to west, 135 mm lens. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 1204, oblique view to west, 135 mm lens. - Travis Air Force Base, Squadron Operations & Readiness Crew Facility, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

Building 931, oblique view to southeast, 135 mm lens. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 931, oblique view to southeast, 135 mm lens. - Travis Air Force Base, Central Battery Charging Building, North of W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

The Desert Tortoise: A Delicate Balance

NASA Technical Reports Server (NTRS)

1992-01-01

This award winning program looks at the efforts to preserve the desert tortoise in and around the Edwards Air Force Base, CA area. It also explains what people should do if they come in contact with a tortoise. This video was produced in cooperation with Edwards Air Force Base.

7. DETAIL SHOWING BLAST SHIELDED WINDOWS, WEST SIDE. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. DETAIL SHOWING BLAST SHIELDED WINDOWS, WEST SIDE. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

5. TETHERED MINUTEMAN MISSILE LAUNCH, TEST AREA 1100. Original is ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. TETHERED MINUTEMAN MISSILE LAUNCH, TEST AREA 1-100. Original is a color print. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

4. DETAIL SHOWING FLAME DEFLECTOR. Looking southeast. Edwards Air ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. DETAIL SHOWING FLAME DEFLECTOR. Looking southeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

5. EAST SIDE, TEST STAND AND ITS SUPERSTRUCTURE. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. EAST SIDE, TEST STAND AND ITS SUPERSTRUCTURE. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

8. SOUTH REAR, SUPERSTRUCTURE. Looking north from deck. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. SOUTH REAR, SUPERSTRUCTURE. Looking north from deck. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

OFFICE AND INSTRUMENT ROOM SOUTH OF THE WEST TANK ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

OFFICE AND INSTRUMENT ROOM SOUTH OF THE WEST TANK - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Liquid Oxygen & Nitrogen Storage Tank Farm, Intersection of Altair & Jupiter Boulevards, Boron, Kern County, CA

5. NORTHEAST CORNER. View to southwest from below. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. NORTHEAST CORNER. View to southwest from below. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

7. INTERIOR, STEEL BLAST DOORS, INSTRUMENTATION ROOM. Edwards Air ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. INTERIOR, STEEL BLAST DOORS, INSTRUMENTATION ROOM. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-4, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Enhanced solar evaporation of water from porous media, through capillary mediated forces and surface treatment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canbazoglu, F. M.; Fan, B.; Kargar, A.

2016-08-15

The relative influence of the capillary, Marangoni, and hydrophobic forces in mediating the evaporation of water from carbon foam based porous media, in response to incident solar radiation, are investigated. It is indicated that inducing hydrophilic interactions on the surface, through nitric acid treatment of the foams, has a similar effect to reduced pore diameter and the ensuing capillary forces. The efficiency of water evaporation may be parameterized through the Capillary number (Ca), with a lower Ca being preferred. The proposed study is of much relevance to efficient solar energy utilization.

Environmental Impact Analysis Process, Environmental Assessment Space Test Experiments Platform Mission 3, Vandenberg Air Force Base, CA

DTIC Science & Technology

1994-09-01

Scientist LOCAL AGENCIES Santa Barbara County Air Pollution Control District, California Hallerman , Richard Air Quality Specialist 6-1 APPENDIX A REFERENCES...Vandenberg Air Force Base. Provided by Richard Hallerman , SBCAPCD, to Bob Baxter, Engineering-Science. 11 June. ____, 1991. Santa Barbara County Air

4. Credit USAF, ca. 1945. Original housed in the Photograph ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Credit USAF, ca. 1945. Original housed in the Photograph Files, AFFTC/HO, Edwards AFB, California. Low level oblique aerial view of Muroc Flight Test Base (North Base), looking southwest along flightline. HANG-P-A hangar (Building 4505) is in the right foreground. A Bell XP-59A Airacomet, the United States military's first jet propelled aircraft, is being towed on the apron toward the control tower. Other aircraft in the foreground include Douglas DC-3s, North American Aviation P-51 Mustangs, and Lockheed P-38 Lightnings. - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

14. Photocopy of photograph (original photograph in possession of 30th ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of photograph (original photograph in possession of 30th Audiovisual Squadron, Vandenberg Air Force Base, California). Photography by United States Air Force, date unknown. ATLAS VEHICLE BEING PREPARED FOR LAUNCH FROM SLC-3E. NOTE EXTERNAL SHEATHING AND CUPOLA ON MOBILE SERVICE TOWER. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Store-operated Ca²⁺ entry and depolarization explain the anomalous behaviour of myometrial SR: effects of SERCA inhibition on electrical activity, Ca²⁺ and force.

PubMed

Noble, Debbie; Borysova, Lyudmyla; Wray, Susan; Burdyga, Theodor

2014-09-01

In the myometrium SR Ca(2+) depletion promotes an increase in force but unlike several other smooth muscles, there is no Ca(2+) sparks-STOCs coupling mechanism to explain this. Given the importance of the control of contractility for successful parturition, we have examined, in pregnant rat myometrium, the effects of SR Ca(2+)-ATPase (SERCA) inhibition on the temporal relationship between action potentials, Ca(2+) transients and force. Simultaneous recording of electrical activity, calcium and force showed that SERCA inhibition, by cyclopiazonic acid (CPA 20 μM), caused time-dependent changes in excitability, most noticeably depolarization and elevations of baseline [Ca(2+)]i and force. At the onset of these changes there was a prolongation of the bursts of action potentials and a corresponding series of Ca(2+) spikes, which increased the amplitude and duration of contractions. As the rise of baseline Ca(2+) and depolarization continued a point was reached when electrical and Ca(2+) spikes and phasic contractions ceased, and a maintained, tonic force and Ca(2+) was produced. Lanthanum, a non-selective blocker of store-operated Ca(2+) entry, but not the L-type Ca(2+) channel blocker nifedipine (1-10 μM), could abolish the maintained force and calcium. Application of the agonist, carbachol, produced similar effects to CPA, i.e. depolarization, elevation of force and calcium. A brief, high concentration of carbachol, to cause SR Ca(2+) depletion without eliciting receptor-operated channel opening, also produced these results. The data obtained suggest that in pregnant rats SR Ca(2+) release is coupled to marked Ca(2+) entry, via store operated Ca(2+) channels, leading to depolarization and enhanced electrical and mechanical activity. Copyright © 2014. Published by Elsevier Ltd.

2. SOUTHEAST SIDE. HIGH PRESSURE HELIUM STORAGE TANKS AT LEFT. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. SOUTHEAST SIDE. HIGH PRESSURE HELIUM STORAGE TANKS AT LEFT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Helium Compression Plant, Test Area 1-115, intersection of Altair & Saturn Boulevards, Boron, Kern County, CA

Observation hall along west side. Looking south to escape ladder. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Observation hall along west side. Looking south to escape ladder. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

12. "TAPE ROOM" LOCATED AT SOUTHEAST CORNER OF MAIN ROOM. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. "TAPE ROOM" LOCATED AT SOUTHEAST CORNER OF MAIN ROOM. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

1. NORTHWEST SIDE AND SOUTHWEST FRONT. Looking east. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. NORTHWEST SIDE AND SOUTHWEST FRONT. Looking east. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Firing Control Building, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

1. OVERVIEW OF DECK AND EAST ELEVATION. Looking northwest. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. OVERVIEW OF DECK AND EAST ELEVATION. Looking northwest. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Detail, rear door types, building 242, oblique view to southwest, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail, rear door types, building 242, oblique view to southwest, 90 mm lens. - Travis Air Force Base, Nuclear Weapons Assembly Building, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

67. DETAIL OF VIDEO CAMERA CONTROL PANEL LOCATED IMMEDIATELY WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

67. DETAIL OF VIDEO CAMERA CONTROL PANEL LOCATED IMMEDIATELY WEST OF ASSISTANT LAUNCH CONDUCTOR PANEL SHOWN IN CA-133-1-A-66 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

70. DETAIL OF OXYGEN TRANSFER PRESSURE GAUGE IN UPPER LEFT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

70. DETAIL OF OXYGEN TRANSFER PRESSURE GAUGE IN UPPER LEFT CORNER OF SKID ON RIGHT IN CA-133-1-C-69 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

6. Credit USAF, ca. 1947. Original housed in the Photograph ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Credit USAF, ca. 1947. Original housed in the Photograph Files, AFFTC/HO, Edwards AFB, California. Interior of Building 4401 (or possibly 4402) looking east at hangar doors with a North American Aviation XB-45 Tornado jet aircraft in the foreground. This view illustrates why the series of sliding doors and wide, high interior clearances were necessary to accommodate large aircraft. Note configuration of wooden trusses supporting the roof. - Edwards Air Force Base, North Base, Hangar No. 1, First & B Streets, Boron, Kern County, CA

TNFα enhances force generation in airway smooth muscle

PubMed Central

Han, Young-Soo; Delmotte, Philippe

2017-01-01

Airway inflammation is a hallmark of asthma, triggering airway smooth muscle (ASM) hyperreactivity and airway remodeling. TNFα increases both agonist-induced cytosolic Ca2+ concentration ([Ca2+]cyt) and force in ASM. The effects of TNFα on ASM force may also be due to an increase in Ca2+ sensitivity, cytoskeletal remodeling, and/or changes in contractile protein content. We hypothesized that 24 h of exposure to TNFα increases ASM force by changing actin and myosin heavy chain (MyHC) content and/or polymerization. Porcine ASM strips were permeabilized with 10% Triton X-100, and force was measured in response to increasing concentrations of Ca2+ (pCa 9.0 to 4.0) in control and TNFα-treated groups. Relative phosphorylation of the regulatory myosin light chain (p-MLC) and total actin, MLC, and MyHC concentrations were quantified at pCa 9.0, 6.1, and 4.0. Actin polymerization was quantified by the ratio of filamentous to globular actin at pCa 9.0 and 4.0. For determination of total cross-bridge formation, isometric ATP hydrolysis rate at pCa 4.0 was measured using an enzyme-coupled NADH-linked fluorometric technique. Exposure to TNFα significantly increased force across the range of Ca2+ activation but did not affect the intrinsic Ca2+ sensitivity of force generation. The TNFα-induced increase in ASM force was associated with an increase in total actin, MLC, and MyHC content, as well as an increase in actin polymerization and an increase in maximum isometric ATP hydrolysis rate. The results of this study support our hypothesis that TNFα increases force generation in ASM by increasing the number of contractile units (actin-myosin content) contributing to force generation. PMID:28385814

Activation Dependence of Stretch Activation in Mouse Skinned Myocardium: Implications for Ventricular Function

PubMed Central

Stelzer, Julian E.; Larsson, Lars; Fitzsimons, Daniel P.; Moss, Richard L.

2006-01-01

Recent evidence suggests that ventricular ejection is partly powered by a delayed development of force, i.e., stretch activation, in regions of the ventricular wall due to stretch resulting from torsional twist of the ventricle around the apex-to-base axis. Given the potential importance of stretch activation in cardiac function, we characterized the stretch activation response and its Ca2+ dependence in murine skinned myocardium at 22°C in solutions of varying Ca2+ concentrations. Stretch activation was induced by suddenly imposing a stretch of 0.5–2.5% of initial length to the isometrically contracting muscle and then holding the muscle at the new length. The force response to stretch was multiphasic: force initially increased in proportion to the amount of stretch, reached a peak, and then declined to a minimum before redeveloping to a new steady level. This last phase of the response is the delayed force characteristic of myocardial stretch activation and is presumably due to increased attachment of cross-bridges as a consequence of stretch. The amplitude and rate of stretch activation varied with Ca2+ concentration and more specifically with the level of isometric force prior to the stretch. Since myocardial force is regulated both by Ca2+ binding to troponin-C and cross-bridge binding to thin filaments, we explored the role of cross-bridge binding in the stretch activation response using NEM-S1, a strong-binding, non-force–generating derivative of myosin subfragment 1. NEM-S1 treatment at submaximal Ca2+-activated isometric forces significantly accelerated the rate of the stretch activation response and reduced its amplitude. These data show that the rate and amplitude of myocardial stretch activation vary with the level of activation and that stretch activation involves cooperative binding of cross-bridges to the thin filament. Such a mechanism would contribute to increased systolic ejection in response to increased delivery of activator Ca2+ during excitation–contraction coupling. PMID:16446502

San Antonio Creek Restoration, Vandenberg Air Force Base, California

DTIC Science & Technology

2008-06-27

Management (Section 4.5), Human Health and Safety (Section 4.6), Land Use and Aesthetics (Section 4.7), 1 FINAL DRAFT and Transportation...Environmental Assessment for the San Antonio Creek Restoration at Vandenberg Air Force Base, California Environmental, Safety , and Occupational Health...Environmental, Safety , and Occupational Health Council Vandenberg AFB, CA MAJCOM Approval

CloudSat Preps for Launch at Vandenberg Air Force Base, CA

NASA Technical Reports Server (NTRS)

2005-01-01

The CloudSat spacecraft sits encapsulated within its Boeing Delta launch vehicle dual payload attach fitting at Vandenberg Air Force Base, Calif. CloudSat will share its ride to orbit late next month with NASA's CALIPSO spacecraft. The two spacecraft are designed to reveal the secrets of clouds and aerosols.

4. DETAIL SHOWING PERISCOPE AND SHIELDED WINDOWS ON EAST SIDE, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. DETAIL SHOWING PERISCOPE AND SHIELDED WINDOWS ON EAST SIDE, NORTH PART. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

14. OBSERVATION HALL ALONG WEST SIDE. Looking south to escape ...

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14. OBSERVATION HALL ALONG WEST SIDE. Looking south to escape ladder. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

2. DETAIL, EAST ENTRANCE, SHOWING OUTER BLAST DOOR AND INNER ...

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2. DETAIL, EAST ENTRANCE, SHOWING OUTER BLAST DOOR AND INNER DOORS. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

11. CONTROL ROOM INTERIOR, SHOWING SEVERAL PERISCOPES. Looking north along ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. CONTROL ROOM INTERIOR, SHOWING SEVERAL PERISCOPES. Looking north along west wall. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

8. NORTH PART OF ROOF, WITH PERISCOPES ALSO SHOWING WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. NORTH PART OF ROOF, WITH PERISCOPES ALSO SHOWING WEST SIDE. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

NORTH REAR AND WEST SIDE, Looking southeast down Saturn Boulevard. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

NORTH REAR AND WEST SIDE, Looking southeast down Saturn Boulevard. February, 1998 - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Electrical Substation, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

2. BUILDING 8767, SOUTH FRONT AND EAST SIDE. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. BUILDING 8767, SOUTH FRONT AND EAST SIDE. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

7. MOTION PICTURE CAMERA STAND AT BUILDING 8768. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. MOTION PICTURE CAMERA STAND AT BUILDING 8768. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

6. BUILDING 8768, NORTHWEST SIDE AND SOUTHWEST FRONT. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. BUILDING 8768, NORTHWEST SIDE AND SOUTHWEST FRONT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

4. INSTRUMENT ROOM,INTERIOR, MAIN SPACE. Looking northeast. Edwards Air ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. INSTRUMENT ROOM,INTERIOR, MAIN SPACE. Looking northeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Firing Control Building, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

8. BUILDING 8769, WEST FRONT AND SOUTH SIDE. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. BUILDING 8769, WEST FRONT AND SOUTH SIDE. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

14. DETAIL SHOWING HYDROGEN (LEFT) AND OXYGEN (RIGHT) PREVALVES. Looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. DETAIL SHOWING HYDROGEN (LEFT) AND OXYGEN (RIGHT) PREVALVES. Looking southeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

17. DETAIL, FOURTEENINCH LIQUID OXYGEN BALL VALVE. Looking south southeast. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. DETAIL, FOURTEEN-INCH LIQUID OXYGEN BALL VALVE. Looking south southeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

SOUTH SIDE OF TANKS. LOADING DOCK, WITH FIRST AID STATION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTH SIDE OF TANKS. LOADING DOCK, WITH FIRST AID STATION IN LEFT FOREGROUND - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Liquid Oxygen & Nitrogen Storage Tank Farm, Intersection of Altair & Jupiter Boulevards, Boron, Kern County, CA

6. DETAIL, WEST SIDE, SOUTH BAY, SHOWING ENTRANCE TO INSTRUMENTATION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. DETAIL, WEST SIDE, SOUTH BAY, SHOWING ENTRANCE TO INSTRUMENTATION ROOM. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-4, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Building 932, oblique view to northwest, 90 mm lens. Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 932, oblique view to northwest, 90 mm lens. Building 933-935 at extreme left. - Travis Air Force Base, Nuclear Weapons Assembly Plant 5, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

Building 930, oblique view to southeast from fill slope covering ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 930, oblique view to southeast from fill slope covering building 932, 135 mm lens. - Travis Air Force Base, Snack Bar, North of W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

Credit BG. View looks south southeast (162°) across foundation of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. View looks south southeast (162°) across foundation of Building 4332 Warehouse "B" (formerly T-81). Top of foundation for Building 4332 Warehouse "A" is visible at extreme left of view. In remote distance are buildings at Main Base, Edwards Air Force Base - Edwards Air Force Base, North Base, Warehouse B, Second Street at E Street, Boron, Kern County, CA

23. "GAFFTC 20 APR 60, H65A F106A; ESCAPE SYSTEM RUN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. "G-AFFTC 20 APR 60, H-6-5A F-106A; ESCAPE SYSTEM RUN 5A." Testing the ejection system on a Convair sled. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

Molecular Mechanisms of Ultrafiltration Membrane Fouling in Polymer-Flooding Wastewater Treatment: Role of Ions in Polymeric Fouling.

PubMed

Liu, Guicai; Yu, Shuili; Yang, Haijun; Hu, Jun; Zhang, Yi; He, Bo; Li, Lei; Liu, Zhiyuan

2016-02-02

Polymer (i.e., anionic polyacrylamide (APAM)) fouling of polyvinylidene fluoride (PVDF) ultrafiltration (UF) membranes and its relationships to intermolecular interactions were investigated using atomic force microscopy (AFM). Distinct relations were obtained between the AFM force spectroscopy measurements and calculated fouling resistance over the concentration polarization layer (CPL) and gel layer (GL). The measured maximum adhesion forces (Fad,max) were closely correlated with the CPL resistance (Rp), and the proposed molecular packing property (largely based on the shape of AFM force spectroscopy curve) of the APAM chains was related to the GL resistance (Rg). Calcium ions (Ca(2+)) and sodium ions (Na(+)) caused more severe fouling. In the presence of Ca(2+), the large Rp corresponded to high foulant-foulant Fad,max, resulting in high flux loss. In addition, the Rg with Ca(2+) was minor, but the flux recovery rate after chemical cleaning was the lowest, indicating that Ca(2+) created more challenges in GL cleaning. With Na(+), the fouling behavior was complicated and concentration-dependent. The GL structures with Na(+), which might correspond to the proposed molecular packing states among APAM chains, played essential roles in membrane fouling and GL cleaning.

The role of tensor force in heavy-ion fusion dynamics

NASA Astrophysics Data System (ADS)

Guo, Lu; Simenel, Cédric; Shi, Long; Yu, Chong

2018-07-01

The tensor force is implemented into the time-dependent Hartree-Fock (TDHF) theory so that both exotic and stable collision partners, as well as their dynamics in heavy-ion fusion, can be described microscopically. The role of tensor force on fusion dynamics is systematically investigated for 40Ca +40Ca , 40Ca +48Ca , 48Ca +48Ca , 48Ca +56Ni , and 56Ni +56Ni reactions which vary by the total number of spin-unsaturated magic numbers in target and projectile. A notable effect on fusion barriers and cross sections is observed by the inclusion of tensor force. The origin of this effect is analyzed. The influence of isoscalar and isovector tensor terms is investigated with the TIJ forces. These effects of tensor force in fusion dynamics are essentially attributed to the shift of low-lying vibration states of colliding partners and nucleon transfer in the asymmetric reactions. Our calculations of above-barrier fusion cross sections also show that tensor force does not significantly affect the dynamical dissipation at near-barrier energies.

5. INTERIOR, LOOKING PAST HELIUM COMPRESSORS NO. 3 AND NO. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. INTERIOR, LOOKING PAST HELIUM COMPRESSORS NO. 3 AND NO. 2, TO NORTHEAST FRONT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Helium Compression Plant, Test Area 1-115, intersection of Altair & Saturn Boulevards, Boron, Kern County, CA

8. ORIGINAL HELIUM COMPRESSOR, CIRCA 1957, BY HASKELL ENGINEERING, GLENDALE, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. ORIGINAL HELIUM COMPRESSOR, CIRCA 1957, BY HASKELL ENGINEERING, GLENDALE, CALIFORNIA. Looking north. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Helium Compression Plant, Test Area 1-115, intersection of Altair & Saturn Boulevards, Boron, Kern County, CA

13. OBSERVATION HALL ALONG WEST SIDE. DOUBLE DOORS LEAD TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. OBSERVATION HALL ALONG WEST SIDE. DOUBLE DOORS LEAD TO MAIN ROOM. Looking north. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

6. NORTH REAR, WEST PART. VIEW TO SOUTHWEST. TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. NORTH REAR, WEST PART. VIEW TO SOUTHWEST. TEST STAND 1-5 AT RIGHT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

6. UNDERGROUND FIRING CONTROL ROOM, INTERIOR. Looking southeast to escape ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. UNDERGROUND FIRING CONTROL ROOM, INTERIOR. Looking southeast to escape tunnel. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Firing Control Building, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

1. MINUTEMAN SILO INTERIOR (MARCH 1961). Looking down a silo. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. MINUTEMAN SILO INTERIOR (MARCH 1961). Looking down a silo. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

1. LOOKING SOUTH TO THE CONTROL CENTER FROM THE EAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. LOOKING SOUTH TO THE CONTROL CENTER FROM THE EAST SIDE OF TEST STAND 1-A. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

24. SATURN V Fl ENGINE TEST FIRING ON TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. SATURN V F-l ENGINE TEST FIRING ON TEST STAND 1A. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

11. DETAIL SHOWING ROLLING ENGINE DECK AND NORTHEAST TRUSS OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. DETAIL SHOWING ROLLING ENGINE DECK AND NORTHEAST TRUSS OF SUPERSTRUCTURE. Looking northeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

16. DETAIL SHOWING LIQUID OXYGEN TANK FOURTEENINCH BALL VALVE. Looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. DETAIL SHOWING LIQUID OXYGEN TANK FOURTEEN-INCH BALL VALVE. Looking southwest. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

22. DETAIL, TWO LIGHTING TYPES AT REAR OF TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. DETAIL, TWO LIGHTING TYPES AT REAR OF TEST STAND 1-A. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

NORTH SIDES OF LIQUID OXYGEN TANKS. Looking southwest along railroad ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

NORTH SIDES OF LIQUID OXYGEN TANKS. Looking southwest along railroad track to AF Plant 72 - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Liquid Oxygen & Nitrogen Storage Tank Farm, Intersection of Altair & Jupiter Boulevards, Boron, Kern County, CA

Building 909, oblique view to southeast, 135 mm lens. Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 909, oblique view to southeast, 135 mm lens. Building 908 at extreme right for context. - Travis Air Force Base, Handling Crew Building, North of W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

73. DETAIL OF LIQUID OXYGEN STORAGE PRESSURE GAUGE IN UPPER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

73. DETAIL OF LIQUID OXYGEN STORAGE PRESSURE GAUGE IN UPPER LEFT CORNER OF WEST SIDE OF CENTER SKID IN CA-133-1-C-69 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210.

PubMed

Inoue, Takahiro; Kobirumaki-Shimozawa, Fuyu; Kagemoto, Tatsuya; Fujii, Teruyuki; Terui, Takako; Kusakari, Yoichiro; Hongo, Kenichi; Morimoto, Sachio; Ohtsuki, Iwao; Hashimoto, Kazuhiro; Fukuda, Norio

2013-10-01

It has been reported that the Frank-Starling mechanism is coordinately regulated in cardiac muscle via thin filament "on-off" equilibrium and titin-based lattice spacing changes. In the present study, we tested the hypothesis that the deletion mutation ΔK210 in the cardiac troponin T gene shifts the equilibrium toward the "off" state and accordingly attenuate the sarcomere length (SL) dependence of active force production, via reduced cross-bridge formation. Confocal imaging in isolated hearts revealed that the cardiomyocytes were enlarged, especially in the longitudinal direction, in ΔK210 hearts, with striation patterns similar to those in wild type (WT) hearts, suggesting that the number of sarcomeres is increased in cardiomyocytes but the sarcomere length remains unaltered. For analysis of the SL dependence of active force, skinned muscle preparations were obtained from the left ventricle of WT and knock-in (ΔK210) mice. An increase in SL from 1.90 to 2.20μm shifted the mid-point (pCa50) of the force-pCa curve leftward by ~0.21pCa units in WT preparations. In ΔK210 muscles, Ca(2+) sensitivity was lower by ~0.37pCa units, and the SL-dependent shift of pCa50, i.e., ΔpCa50, was less pronounced (~0.11pCa units), with and without protein kinase A treatment. The rate of active force redevelopment was lower in ΔK210 preparations than in WT preparations, showing blunted thin filament cooperative activation. An increase in thin filament cooperative activation upon an increase in the fraction of strongly bound cross-bridges by MgADP increased ΔpCa50 to ~0.21pCa units. The depressed Frank-Starling mechanism in ΔK210 hearts is the result of a reduction in thin filament cooperative activation. © 2013.

Credit USAF, 7 September 1945. Original housed in the Muroc ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit USAF, 7 September 1945. Original housed in the Muroc Flight Test Base, Unit History, 1 September 1942 - 30 June 1945. Alfred F. Simpson Historical Research Agency. United States Air Force. Maxwell AFB, Alabama. View of the mess hall, looking to the north. Sign over door reads "MFTB Muroc Flight Test Base Base Mess." - Edwards Air Force Base, North Base, Base Mess Hall T-27, Third Street, Boron, Kern County, CA

15. Photocopy of drawing (1958 architectural drawing by Ralph M. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of drawing (1958 architectural drawing by Ralph M. Parsons Company. Original drawing in possession of Vandenberg Air Force Base Civil Engineering Office). SITE PLAN FOR POINT ARGUELLO LAUNCH COMPLEX 1 (SLC-3) SHOWING POTENTIAL SITES OF FUTURE PADS. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Intro & Basic R&D Overview for NRC RAP Administrator

DTIC Science & Technology

2011-07-13

Air Force Research Laboratory (AFMC) AFRL /RZS 5 Pollux Drive Edwards AFB CA...NUMBER (include area code) N/A Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. 239.18 1 Air Force Research Laboratory Edwards Air Force ...BOUNDARY 0 5 10 SCALE IN MILES HWY 395 ROSAMOND BLVD. MERCURY BLVD. R O C K ET S IT E R O A D EDWARDS AIR FORCE BASE Air Force Research

3. SOUTHWEST REAR, WITH RAILROAD LINE AT RIGHT. HIGH PRESSURE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. SOUTHWEST REAR, WITH RAILROAD LINE AT RIGHT. HIGH PRESSURE HELIUM STORAGE TANKS AT LEFT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Helium Compression Plant, Test Area 1-115, intersection of Altair & Saturn Boulevards, Boron, Kern County, CA

7. TOP SURFACES OF FOUR HYDRAULIC UNITS TO DRIVE COMPRESSORS. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. TOP SURFACES OF FOUR HYDRAULIC UNITS TO DRIVE COMPRESSORS. Looking southeast along rear of building. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Helium Compression Plant, Test Area 1-115, intersection of Altair & Saturn Boulevards, Boron, Kern County, CA

1. EAST ENTRANCE FROM LOADING AREA. CONCRETE TUNNEL TO TEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. EAST ENTRANCE FROM LOADING AREA. CONCRETE TUNNEL TO TEST STAND 1-3 IS AT RIGHT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

9. BUILDING 8769, EAST REAR AND NORTH SIDE, TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. BUILDING 8769, EAST REAR AND NORTH SIDE, TEST STAND AT RIGHT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

3. CABLE TUNNEL TO TEST STAND 1A, LOOKING SOUTH TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. CABLE TUNNEL TO TEST STAND 1-A, LOOKING SOUTH TO STAIRS LEADING UP TO CONTROL CENTER. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

6. DETAIL OF NORTH ELEVATION AND FOOTINGS FOR FLAME DEFLECTOR, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. DETAIL OF NORTH ELEVATION AND FOOTINGS FOR FLAME DEFLECTOR, NOW MISSING. Looking east. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

18. CROWS NEST ATOP SUPERSTRUCTURE. Looking up from northeast corner ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. CROWS NEST ATOP SUPERSTRUCTURE. Looking up from northeast corner of run line deck. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

DELUGE AND WATER RECLAMATION BASIN BELOW TEST STAND 1A. Looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DELUGE AND WATER RECLAMATION BASIN BELOW TEST STAND 1-A. Looking north northwest - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Flame Deflector Water System, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

19. TRAVELING CRANE ATOP SUPERSTRUCTURE, FROM RUN LINE DECK. Looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. TRAVELING CRANE ATOP SUPERSTRUCTURE, FROM RUN LINE DECK. Looking up to north northeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

10. DETAIL SHOWING THRUST MEASURING SYSTEM. Looking up from the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. DETAIL SHOWING THRUST MEASURING SYSTEM. Looking up from the test stand deck to east. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

7. SOUTH REAR. Looking northwest from corner of the Instrumentation ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. SOUTH REAR. Looking northwest from corner of the Instrumentation and Control Building (Building 8762). - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

3. EAST SIDE, ALSO SHOWING COVERED TANKS AND TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. EAST SIDE, ALSO SHOWING COVERED TANKS AND TEST STAND 1-5 AT RIGHT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-4, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Energetic Azido Compounds

DTIC Science & Technology

1980-03-28

Dr. F. Roberto Lt. S. Clift Naval Weapons Center 3 Mr. ;. Geisler Chi•a Lakre, CA 93555 4a Attn: Dr. A. Amsrer, Code 385 U.S. Army Research Office I...Research Naval: Weapons Center 1 Directorate of Chemical Sciences China Lake, CA 93555 Bolling Air Force Base Attn: Mr. H. Richter, Code 3858

High Temperature Gas Energy Transfer.

DTIC Science & Technology

1980-08-12

Office of Naval Research 1 Code 260 Code AFRPL MKPAArlingon, VA 22217 Edwards AFB, CA 93523Attn: Mr. D. Siegel Attn: Dr. F. Roberto Office of Naval...ResearchOffice of Naval Research Directorate of Aero-San Francisco Area Office space SciencesOne allidie Plaza Suite 601 Bolling Air Force BaseSan Francisco, CA

Synthesis of Energetic Polymers.

DTIC Science & Technology

1980-08-15

Code 260 Code AFRPL MKPA Arlingon, VA 22217 Edwards AFB, CA 93523 Attn: Mr. D. Siegel Attn: Dr. F. Roberto Office of Naval Research I AFSC Western Office...Research I Directorate of Aero- San Francisco Area Office space Sciences One Hallidie Plaza Suite 601 Bolling Air Force Base San Francisco, CA 94102

25. "GAFFTC 19 OCT 60, BLAST EFFECTS ON AIRFOILS, STATIC ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. "G-AFFTC 19 OCT 60, BLAST EFFECTS ON AIRFOILS, STATIC RUN 5." View of track rail mounting and the water brake trough at 20,000-foot track. Looking northeast. File no. 12,358-60. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

24. "GAFFTC 29 SEP 60, F106B STATIC TEST 1." Test ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. "G-AFFTC 29 SEP 60, F-106B STATIC TEST 1." Test of the Convair sled escape system at static test site east of Station "50". File no. 11,988-60. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

Development of a Specific Impulse Balance for a Pulsed Capillary Discharge (Preprint)

DTIC Science & Technology

2008-06-13

thrust stand [rad/s] I. Introduction A capillary discharge based coaxial , electrothermal pulsed plasma thruster (PPT) is currently under...20-23 July 2008. 14. ABSTRACT A capillary discharge based pulsed plasma thruster is currently under development at the Air Force Research...Edwards AFB, CA 93524 A capillary discharge based pulsed plasma thruster is currently under development at the Air Force Research Laboratory. A

3. PHOTOCOPY OF DRAWING (1960 ARCHITECTURAL DRAWING BY THE RALPH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. PHOTOCOPY OF DRAWING (1960 ARCHITECTURAL DRAWING BY THE RALPH M. PARSONS COMPANY) FLOOR PLAN, ELEVATIONS, AND SECTION FOR THE SAMOS TECHNICAL SUPPORT BUILDING (BLDG. 761; NOW CALLED SLC-3 AIR FORCE BUILDING), SHEET A14 - Vandenberg Air Force Base, Space Launch Complex 3, SLC-3 Air Force Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

4. PHOTOCOPY OF DRAWING (1960 CIVIL ENGINEERING DRAWING THE THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. PHOTOCOPY OF DRAWING (1960 CIVIL ENGINEERING DRAWING THE THE RALPH M. PARSONS COMPANY) PLOT AND UTILITY PLAN FOR THE SAMOS TECHNICAL SUPPORT BUILDING (BLDG. 761; NOW CALLED SLC-3 AIR FORCE BUILDING), SHEET C47 - Vandenberg Air Force Base, Space Launch Complex 3, SLC-3 Air Force Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Advanced Propulsion Study

DTIC Science & Technology

2004-02-01

outcome. The author wishes to apologize in advance to fellow NASA BPP researchers for not including their work in this report . However, Millis (2003a...San Rafael Ave. Las Vegas, NV 89120 September 2004 Special Report APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED...AIR FORCE RESEARCH LABORATORY AIR FORCE MATERIEL COMMAND EDWARDS AIR FORCE BASE CA 93524-7048 REPORT DOCUMENTATION PAGE Form Approved

Credit USAF. Original housed in the Muroc Flight Test Base, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit USAF. Original housed in the Muroc Flight Test Base, Unit History, 1 September 1942 - 30 June 1945. Alfred F. Simpson Historical Research Agency. United States Air Force. Maxwell AFB, Alabama. View captioned as "7 Sept 1945, BH-5 Base Ordinance Motor Repair Shop" with gas station and gasoline pump. View looks roughly northwest - Edwards Air Force Base, North Base, Motor Repair Shop T-16, Third & C Streets, Boron, Kern County, CA

Parameterization of Ca+2-protein interactions for molecular dynamics simulations.

PubMed

Project, Elad; Nachliel, Esther; Gutman, Menachem

2008-05-01

Molecular dynamics simulations of Ca+2 ions near protein were performed with three force fields: GROMOS96, OPLS-AA, and CHARMM22. The simulations reveal major, force-field dependent, inconsistencies in the interaction between the Ca+2 ions with the protein. The variations are attributed to the nonbonded parameterizations of the Ca+2-carboxylates interactions. The simulations results were compared to experimental data, using the Ca+2-HCOO- equilibrium as a model. The OPLS-AA force field grossly overestimates the binding affinity of the Ca+2 ions to the carboxylate whereas the GROMOS96 and CHARMM22 force fields underestimate the stability of the complex. Optimization of the Lennard-Jones parameters for the Ca+2-carboxylate interactions were carried out, yielding new parameters which reproduce experimental data. Copyright 2007 Wiley Periodicals, Inc.

Implement Family Member Assessment Component in the Millennium Cohort Study

DTIC Science & Technology

2010-10-01

Hospital , Camp Pendleton, CA Tyler C. Smith, MS, PhD, DoD Center for Deployment Health Research, NHRC, San Diego CA Col Timothy S. Wells, USAF, BSC, Air...physical health, relationship quality, deployment/ reunion , and service utilization. In addition, data will be linked to medical records collected...Laboratory, Wright-Patterson Air Force Base, OH; and Margaret Ryan from the Naval Hospital Camp Pendleton, Camp Pendleton, CA. Additionally, the

NORTHWEST FRONT AND SOUTHWEST SIDE, BUILDING 1933 Edwards Air ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

NORTHWEST FRONT AND SOUTHWEST SIDE, BUILDING 1933 - Edwards Air Force Base, X-15 Engine Test Complex, Observation Bunker Types, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

3. Credit USAF, ca. 1945. Original housed in the Records ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Credit USAF, ca. 1945. Original housed in the Records of the Defense Intelligence Agency. Record Group 373. National Archives. Cartographic and Architectural Branch. Washington, D.C. Aerial orthophoto map 16PS5M79-IV23 of Muroc Flight Test Base (North Base), north faces up with runway at the top and Rogers Dry Lake at the lower right. Ammunition huts (not extant in 1995) appear in a cluster just south of the west end of the runway. Note runway markings on lakebed. Linear feature at very top of image is rocket sled test track designed and built 1944-1945. - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

3. EAST SIDE FROM ATOP TUNNEL, SHOWING BLAST SHIELDED WINDOWS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. EAST SIDE FROM ATOP TUNNEL, SHOWING BLAST SHIELDED WINDOWS AND PERISCOPE FACING TO TEST STAND 1-3. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

11. OBSERVATION POST NO. 3, NORTH SIDE AND WEST REAR, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. OBSERVATION POST NO. 3, NORTH SIDE AND WEST REAR, TEST STAND AT RIGHT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

8. LOW OBLIQUE AERIAL VIEW OF TEST AREA 1115, SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. LOW OBLIQUE AERIAL VIEW OF TEST AREA 1-115, SHOWING TEST STANDS 1-5, 1-4, AND 1-3 (LEFT TO RIGHT). - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

5. BUILDING 8768, SOUTH SIDE AND EAST REAR. TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. BUILDING 8768, SOUTH SIDE AND EAST REAR. TEST STAND 1A AT LEFT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

9. WEST SIDE, TEST STAND AND SUPERSTRUCTURE. TEST STAND 1B ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. WEST SIDE, TEST STAND AND SUPERSTRUCTURE. TEST STAND 1-B IN DISTANCE. Looking east. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

8. TEST STAND 15, INVERTED ENGINE FIRING TEST, CIRCA 1963. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. TEST STAND 1-5, INVERTED ENGINE FIRING TEST, CIRCA 1963. Original is a color print. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

3. SHOP AREA. Looking west into storage cage from near ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. SHOP AREA. Looking west into storage cage from near northeast corner of room. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

3. BUILDING 8814, WEST SIDE AND SOUTH REAR, SHOWING BLAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. BUILDING 8814, WEST SIDE AND SOUTH REAR, SHOWING BLAST DOOR. BUILDING 8826 IS IN BACKGROUND. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunker 1-D-3, Test Area 1-125, northwest end of Altair Boulevard, Boron, Kern County, CA

2. BUILDING 8814, NORTH FRONT AND EAST SIDE. Looking south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. BUILDING 8814, NORTH FRONT AND EAST SIDE. Looking south southwest toward water tank complex. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunker 1-D-3, Test Area 1-125, northwest end of Altair Boulevard, Boron, Kern County, CA

Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998.

PubMed Central

Dobrunz, L E; Backx, P H; Yue, D T

1995-01-01

We have developed a novel method for measuring steady-state force-[Ca2+]i relations in isolated, membrane-intact rat trabeculae that are microinjected with Fura-2 salt. Twitches are markedly slowed after inhibition of phasic Ca2+ release and uptake from the sarcoplasmic reticulum by addition of cyclopiazonic acid and ryanodine. During relaxation of slowed twitches, force and [Ca2+]i trace a common trajectory in plots of force versus [Ca2+]i, despite very different histories of contraction. The common trajectory thereby provides a high resolution determination of the steady-state relation between force and [Ca2+]i. Using this method, we show that 1 microM isoproterenol, a beta-adrenergic agonist, causes a rightward shift (Hill function K1/2 increased from 0.39 +/- 0.07 microM to 0.82 +/- 0.23 microM, p < 0.02, n = 6) and a decreased slope (nH decreased from 5.4 +/- 1.1 to 4.0 +/- 1.4, p < 0.02) of the steady-state force-[Ca2+]i curve, with no change in maximal force (Fmax = 99.2 +/- 2.2% of control). In contrast, 2 microM EMD 53998, a racemic thiadiazinone derivative, causes a leftward shift (K1/2 decreased from 0.42 +/- 0.02 microM to 0.30 +/- 0.06 microM, p < 0.02, n = 4) with no change in slope of the steady-state force-[Ca2+]i curve, accompanied by a modest increase in maximal force (Fmax = 107.1 +/- 4.6% of control, p < 0.02). To gain mechanistic insight into these modulatory events, we developed a simple model of cooperative thin filament activation that predicts steady-state force-[Ca2+]i relationships. Model analysis suggests that isoproterenol decreases cooperativity arising from nearest-neighbor interactions between regulatory units on the thin filament, without change in the equilibrium constant for Ca2+ binding. In contrast, the effects of EMD 53998 are consistent with an increase in the affinity of strong-binding cross-bridges, without change in either the affinity of troponin C for Ca2+ or cooperative interactions. PMID:7669896

7. Credit USAF, 1945. Original housed in the Muroc Flight ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Credit USAF, 1945. Original housed in the Muroc Flight Test Base, Unit History, 1 September 1942 30 June 1945. Alfred F. Simpson Historical Research Agency. United States Air Force. Maxwell AFB, Alabama. Interior view in shop wing on south side of hangar. Original caption reads "7 Sept. 1945, BH-10, Hangar No. 4 4505 Machine Shop." - Edwards Air Force Base, North Base, Hangar, End of North Base Road, Boron, Kern County, CA

Contractile dysfunctions in ATP-dependent K+ channel-deficient mouse muscle during fatigue involve excessive depolarization and Ca2+ influx through L-type Ca2+ channels.

PubMed

Cifelli, Carlo; Boudreault, Louise; Gong, Bing; Bercier, Jean-Philippe; Renaud, Jean-Marc

2008-10-01

Muscles deficient in ATP-dependent potassium (KATP) channels develop contractile dysfunctions during fatigue that may explain their apparently faster rate of fatigue compared with wild-type muscles. The objectives of this study were to determine: (1) whether the contractile dysfunctions, namely unstimulated force and depressed force recovery, result from excessive membrane depolarization and Ca2+ influx through L-type Ca2+ channels; and (2) whether reducing the magnitude of these two contractile dysfunctions reduces the rate of fatigue in KATP channel-deficient muscles. To reduce Ca2+ influx, we lowered the extracellular Ca2+ concentration ([Ca2+]o) from 2.4 to 0.6 mM or added 1 microM verapamil, an L-type Ca2+ channel blocker. Flexor digitorum brevis (FDB) muscles deficient in KATP channels were obtained by exposing wild-type muscles to 10 microM glibenclamide or by using FDB from Kir6.2-/- mice. Fatigue was elicited with one contraction per second for 3 min at 37 degrees C. In wild-type FDB, lowered [Ca2+]o or verapamil did not affect the decrease in peak tetanic force and unstimulated force during fatigue and force recovery following fatigue. In KATP channel-deficient FDB, lowered [Ca2+]o or verapamil slowed down the decrease in peak tetanic force recovery, reduced unstimulated force and improved force recovery. In Kir6.2-/- FDB, the rate of fatigue became slower than in wild-type FDB in the presence of verapamil. The cell membrane depolarized from -83 to -57 mV in normal wild-type FDB. The depolarizations in some glibenclamide-exposed fibres were similar to those of normal FDB, while in other fibres the cell membrane depolarized to -31 mV in 80 s, which was also the time when these fibres supercontracted. It is concluded that: (1) KATP channels are crucial in preventing excessive membrane depolarization and Ca2+ influx through L-type Ca2+ channels; and (2) they contribute to the decrease in force during fatigue.

1. Photocopy of drawing 1958 architectural drawing by the Ralph ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of drawing 1958 architectural drawing by the Ralph Parsons Company in possession of Vandenberg Air Force Base Civil Engineering Office) FLOOR PLANS, ELEVATIONS, AND DETAILS FOR TRAFFIC CHECK HOUSE (BLDG. 759), AND THEODOLITE SHELTERS, SHEET A9 - Vandenberg Air Force Base, Space Launch Complex 3, Traffic Check House, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

11. Photocopy of photograph (original photograph in possession of Val ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of photograph (original photograph in possession of Val Brose, General Dynamics Space Systems Division, Vandenberg Air Force Base, California). Photographer unknown, circa July 1961. CREW OF FIRST LAUNCH FROM POINT ARGUELLO LAUNCH COMPLEX 1, PAD 2, (SLC-3E) ON LAUNCH PAD. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

SOUTHWEST SIDE OF TANK, WITH ENTRY DOOR. Looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHWEST SIDE OF TANK, WITH ENTRY DOOR. Looking northeast - Edwards Air Force Base, X-15 Engine Test Complex, Tank & Garage, Rogers Dry Lake, east of Runway between North Base & South Base, Boron, Kern County, CA

6. Credit BG. Detail view looking north at Building 4306 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Credit BG. Detail view looking north at Building 4306 (Boiler House) located at southwest corner of Building 4305 (Unicon Portable Hangar). Building retains its original World War II wooden construction and finish. Number sign for Building 4302 belongs to nearby sump pump structure (See HAER photo number CA-170-RR-1) - Edwards Air Force Base, North Base, Unicon Portable Hangar, First & C Streets, Boron, Kern County, CA

34. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Photographic copy of photograph (ca. 1962, original print in possession of Army Corps of Engineers, Ft. Belvoir, Virginia) Photographer unknown. View of launch control facility under construction, security gate at left - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

2. NORTH FRONT, FROM SUPERSTRUCTURE TO FLAME DEFLECTOR. Looking south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. NORTH FRONT, FROM SUPERSTRUCTURE TO FLAME DEFLECTOR. Looking south southwest from Observation Post No. 1 (Building 8767). - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

3. BUILDING 8767, NORTH REAR AND WEST SIDE, TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. BUILDING 8767, NORTH REAR AND WEST SIDE, TEST STAND 1-A AT FAR RIGHT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

5. INSTRUMENT ROOM INTERIOR, SHOWING BACKS OF CONSOLE LOCKERS. Looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. INSTRUMENT ROOM INTERIOR, SHOWING BACKS OF CONSOLE LOCKERS. Looking northeast to firing control room passageway. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Firing Control Building, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

3. NORTHEAST REAR, SHOWING CONCRETE ENCASEMENT FOR STAIRWAY LEADING FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. NORTHEAST REAR, SHOWING CONCRETE ENCASEMENT FOR STAIRWAY LEADING FROM INSTRUMENT ROOM TO UNDERGROUND FIRING CONTROL ROOM. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Firing Control Building, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

12. "SITE PLAN." Test Area 1100. Specifications No. OC35973; Drawing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. "SITE PLAN." Test Area 1-100. Specifications No. OC359-73; Drawing No. 5841-C-1; D.O. SERIES AW1525/7 Rev. A. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

5. NORTH REAR, EAST PART, SHOWING ESCAPE HATCH. TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. NORTH REAR, EAST PART, SHOWING ESCAPE HATCH. TEST STAND 1-3 AND ITS MACHINE SHOP ARE IN MIDDLE DISTANCE. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

4. NORTH END OF TERMINAL ROOM, SHOP LEVEL SHOWING SPIRAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. NORTH END OF TERMINAL ROOM, SHOP LEVEL SHOWING SPIRAL STAIR TO CABLE RACK. Looking north. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

2. TERMINAL ROOM, SHOP LEVEL INTERIOR, SHOWING MEZZANINE LEVEL CABLE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. TERMINAL ROOM, SHOP LEVEL INTERIOR, SHOWING MEZZANINE LEVEL CABLE RACK AT UPPER RIGHT. Looking north. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

13. DETAIL SHOWING OXYGEN (LEFT) AND HYDROGEN (RIGHT) PREVALVES ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. DETAIL SHOWING OXYGEN (LEFT) AND HYDROGEN (RIGHT) PREVALVES ON SECOND DECK OF SUPERSTRUCTURE, ABOVE THE ENGINE. Looking northwest. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

12. DETAIL SHOWING EAST SIDE OF THE OXYGEN AND HYDROGEN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. DETAIL SHOWING EAST SIDE OF THE OXYGEN AND HYDROGEN PRE-VALVE DECK (2ND LEVEL). Looking south. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

10. CONTROL ROOM INTERIOR. Looking into southwest corner. CONTROL ROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. CONTROL ROOM INTERIOR. Looking into southwest corner. CONTROL ROOM INTERIOR, SHOWING ESCAPE HATCH. Looking north along east wall. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Detail, oblique view to northeast atop building 935 showing exposed ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail, oblique view to northeast atop building 935 showing exposed roof sections of buildings 934 (center) and 933 (left), 90 mm lens. - Travis Air Force Base, Nuclear Weapons Assembly Plant 3, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

NORTH SIDE FACING TRACK, SHOWING ELECTRICAL BOX AND CONCRETE VAULT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

NORTH SIDE FACING TRACK, SHOWING ELECTRICAL BOX AND CONCRETE VAULT - Edwards Air Force Base, South Base Sled Track, Electrical Distribution Station, South side of Sled Track, Lancaster, Los Angeles County, CA

5. INTERIOR, INSTRUMENTATION AND CONTROL BUILDING ADDITION. Looking north. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. INTERIOR, INSTRUMENTATION AND CONTROL BUILDING ADDITION. Looking north. - Edwards Air Force Base, South Base Sled Track, Instrumentation & Control Building, South of Sled Track, Station "50" area, Lancaster, Los Angeles County, CA

4. NORTHWEST FRONT, WITH FOUR BULLET GLASS WINDOWS. Edwards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. NORTHWEST FRONT, WITH FOUR BULLET GLASS WINDOWS. - Edwards Air Force Base, South Base Sled Track, Observation Block House, Station "O" area, east end of Sled Track, Lancaster, Los Angeles County, CA

5. BUILDING 0503, INTERIOR WOODEN ARCHES. Looking south from entrance. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. BUILDING 0503, INTERIOR WOODEN ARCHES. Looking south from entrance. - Edwards Air Force Base, South Base Sled Track, Earth Covered Bunker Types, North of Sled Track, Lancaster, Los Angeles County, CA

Quantum Chemical Investigations of the Mechanism of Cationic Polymerization.

DTIC Science & Technology

1980-10-15

of Naval Research I Code 260 Code AFRPL MKPA Arlingon, VA 22217 Edwards AFB, CA 93523 Attn: Mr. D. Siegel Attn: Dr. F. Roberto Office of Naval...495 Summer Street Bolling Air Force BaseBoston, MA 02210 Washington, DC 20332 Attn: Dr. L. Peebles Dr. A. Wood Air Force Office of 1~Scientific...Research 4 Office of Naval Research 1 Directorate of Aero- San Francisco Area Office space Sciences One HaITidie Plaza Suite 601 Bolling Air Force Base San

Environmental Impact Analysis Process. Environmental Assessment Air Force Small Launch Vehicle, Vandenberg Air Force Base, Edwards Air Force Base, and San Nicolas Island, CA

DTIC Science & Technology

1991-05-01

a historical breeding area, may be related to summer flooding in 1984, 1985, and 1987, which rendered the habitat unsuitable to the least terns...animal fetishes (de Cessac, 1951; Meighan and Eberhart, 1953; Heizer , 1957, 1960a and 1960b; Rozaire, 1959; Reinman and Townsend, 1960; Reinman...interest, and there are several published accounts of her life ( Heizer and Elsasser, n.d.). 2-168 Several archaeological surveys have been

Rate-dependent Ca2+ signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study

PubMed Central

2013-01-01

Background Rate-dependent effects on the Ca2+ sub-system in a rat ventricular myocyte are investigated. Here, we employ a deterministic mathematical model describing various Ca2+ signalling pathways under voltage clamp (VC) conditions, to better understand the important role of calmodulin (CaM) in modulating the key control variables Ca2+/calmodulin-dependent protein kinase-II (CaMKII), calcineurin (CaN), and cyclic adenosine monophosphate (cAMP) as they affect various intracellular targets. In particular, we study the frequency dependence of the peak force generated by the myofilaments, the force-frequency response (FFR). Methods Our cell model incorporates frequency-dependent CaM-mediated spatially heterogenous interaction of CaMKII and CaN with their principal targets (dihydropyridine (DHPR) and ryanodine (RyR) receptors and the SERCA pump). It also accounts for the rate-dependent effects of phospholamban (PLB) on the SERCA pump; the rate-dependent role of cAMP in up-regulation of the L-type Ca2+ channel (ICa,L); and the enhancement in SERCA pump activity via phosphorylation of PLB. Results Our model reproduces positive peak FFR observed in rat ventricular myocytes during voltage-clamp studies both in the presence/absence of cAMP mediated β-adrenergic stimulation. This study provides quantitative insight into the rate-dependence of Ca2+-induced Ca2+-release (CICR) by investigating the frequency-dependence of the trigger current (ICa,L) and RyR-release. It also highlights the relative role of the sodium-calcium exchanger (NCX) and the SERCA pump at higher frequencies, as well as the rate-dependence of sarcoplasmic reticulum (SR) Ca2+ content. A rigorous Ca2+ balance imposed on our investigation of these Ca2+ signalling pathways clarifies their individual roles. Here, we present a coupled electromechanical study emphasizing the rate-dependence of isometric force developed and also investigate the temperature-dependence of FFR. Conclusions Our model provides mechanistic biophysically based explanations for the rate-dependence of CICR, generating useful and testable hypotheses. Although rat ventricular myocytes exhibit a positive peak FFR in the presence/absence of beta-adrenergic stimulation, they show a characteristic increase in the positive slope in FFR due to the presence of Norepinephrine or Isoproterenol. Our study identifies cAMP-mediated stimulation, and rate-dependent CaMKII-mediated up-regulation of ICa,L as the key mechanisms underlying the aforementioned positive FFR. PMID:24020888

47. BASE OF UMBILICAL MAST, WITH ELECTRICAL POWER CABLES ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. BASE OF UMBILICAL MAST, WITH ELECTRICAL POWER CABLES ON LEFT; AIR-CONDITIONER DUCTS ON RIGHT - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

SOUTHWEST REAR, SHOWING CLOSED ENTRY HATCH, BUILDING 1934. Looking north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHWEST REAR, SHOWING CLOSED ENTRY HATCH, BUILDING 1934. Looking north - Edwards Air Force Base, X-15 Engine Test Complex, Observation Bunker Types, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

VIEW OF TANK (BLDG. 1929) AND GARAGE (BLDG. 1930). Looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF TANK (BLDG. 1929) AND GARAGE (BLDG. 1930). Looking northwest - Edwards Air Force Base, X-15 Engine Test Complex, Tank & Garage, Rogers Dry Lake, east of Runway between North Base & South Base, Boron, Kern County, CA

1. Credit PSR. View looks north from aircraft apron at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Credit PSR. View looks north from aircraft apron at south and east facades of the first hangar built at North Base in 1942. Note Building 4306 attached to hangar in distance; this structure is the boiler house to heat hangar during winters. Cable reels in foreground are from fiber optic and electrical cable installations ongoing at Edwards Air Force Base. - Edwards Air Force Base, North Base, Unicon Portable Hangar, First & C Streets, Boron, Kern County, CA

9. DETAIL, ROOF VENT HOUSING. NOTE THE TUNNEL TO TEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. DETAIL, ROOF VENT HOUSING. NOTE THE TUNNEL TO TEST STAND 1-3 AT FAR LEFT, AND ITS MACHINE SHOP AT LEFT CENTER. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Instrumentation & Control Building, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

3. DETAIL OF NORTH FRONT AND WEST SIDE, WITH SUPERSTRUCTURE, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. DETAIL OF NORTH FRONT AND WEST SIDE, WITH SUPERSTRUCTURE, FROM NEAR OBSERVATION POST NO. 3. Looking south southeast from below. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

10. OBSERVATION POST NO. 3, WEST OF TEST STAND 1A. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. OBSERVATION POST NO. 3, WEST OF TEST STAND 1-A. SOUTH SIDE AND EAST FRONT. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

1. BUILDING 8814, NORTH FRONT AND WEST SIDE. BUILDING 8832, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. BUILDING 8814, NORTH FRONT AND WEST SIDE. BUILDING 8832, TEST STAND 1-E, IN LEFT DISTANCE. Looking southeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunker 1-D-3, Test Area 1-125, northwest end of Altair Boulevard, Boron, Kern County, CA

2. AERIAL VIEW OF MINUTEMAN SILOS. Low oblique aerial view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. AERIAL VIEW OF MINUTEMAN SILOS. Low oblique aerial view (original in color) of the two launch silos, covered. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

PUMP SETS NO. 5 AND NO. 4. Each pump set ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PUMP SETS NO. 5 AND NO. 4. Each pump set consists of a Worthington Pump and a General Electric motor - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Flame Deflector Water System, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

ONE MILLION GALLON WATER TANK, PUMP HEADER PIPE (AT LEFT), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ONE MILLION GALLON WATER TANK, PUMP HEADER PIPE (AT LEFT), HEADER BYPASS PIPE (AT RIGHT), AND PUMPHOUSE FOUNDATIONS. Looking northeast - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Flame Deflector Water System, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

6. CABLE RACK, MEZZANINE LEVEL, INTERIOR OF TEST STAND 1A. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. CABLE RACK, MEZZANINE LEVEL, INTERIOR OF TEST STAND 1A. Looking south from north wall of terminal room. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

GENERAL VIEW OF PUMPHOUSE FOUNDATIONS, ALSO SHOWING THREE PUMPS STILL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF PUMPHOUSE FOUNDATIONS, ALSO SHOWING THREE PUMPS STILL ON THE PAD, AND THE ELECTRICAL SUBSTATION IN LEFT MIDDLE DISTANCE - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Flame Deflector Water System, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

20. DECOMMISIONED HYDROGEN TANK IN FORMER LIQUID OXYGEN STORAGE AREA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. DECOMMISIONED HYDROGEN TANK IN FORMER LIQUID OXYGEN STORAGE AREA, BETWEEN TEST STAND 1-A AND INSTRUMENTATION AND CONTROL BUILDING. Looking northwest. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

Building 933935, oblique view to southeast showing, left to right, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 933-935, oblique view to southeast showing, left to right, rear doors to building 933, 934, 935, 90 mm lens. Building 933 is in foreground. - Travis Air Force Base, Nuclear Weapons Assembly Plant 4, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

7. ROCKET SLED ON DECK OF TEST STAND 15. Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. ROCKET SLED ON DECK OF TEST STAND 1-5. Photo no. "6085, G-EAFB-16 SEP 52." Looking south to machine shop. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Computational analysis of the regulation of Ca2+ dynamics in rat ventricular myocytes

NASA Astrophysics Data System (ADS)

Bugenhagen, Scott M.; Beard, Daniel A.

2015-10-01

Force-frequency relationships of isolated cardiac myocytes show complex behaviors that are thought to be specific to both the species and the conditions associated with the experimental preparation. Ca2+ signaling plays an important role in shaping the force-frequency relationship, and understanding the properties of the force-frequency relationship in vivo requires an understanding of Ca2+ dynamics under physiologically relevant conditions. Ca2+ signaling is itself a complicated process that is best understood on a quantitative level via biophysically based computational simulation. Although a large number of models are available in the literature, the models are often a conglomeration of components parameterized to data of incompatible species and/or experimental conditions. In addition, few models account for modulation of Ca2+ dynamics via β-adrenergic and calmodulin-dependent protein kinase II (CaMKII) signaling pathways even though they are hypothesized to play an important regulatory role in vivo. Both protein-kinase-A and CaMKII are known to phosphorylate a variety of targets known to be involved in Ca2+ signaling, but the effects of these pathways on the frequency- and inotrope-dependence of Ca2+ dynamics are not currently well understood. In order to better understand Ca2+ dynamics under physiological conditions relevant to rat, a previous computational model is adapted and re-parameterized to a self-consistent dataset obtained under physiological temperature and pacing frequency and updated to include β-adrenergic and CaMKII regulatory pathways. The necessity of specific effector mechanisms of these pathways in capturing inotrope- and frequency-dependence of the data is tested by attempting to fit the data while including and/or excluding those effector components. We find that: (1) β-adrenergic-mediated phosphorylation of the L-type calcium channel (LCC) (and not of phospholamban (PLB)) is sufficient to explain the inotrope-dependence; and (2) that CaMKII-mediated regulation of neither the LCC nor of PLB is required to explain the frequency-dependence of the data.

30. "CONSTRUCTION PHASING, STATION '50' AREA." Specifications No. ENG043535775, Drawing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. "CONSTRUCTION PHASING, STATION '50' AREA." Specifications No. ENG-04-353-57-75, Drawing No. AF-4502-19, sheet 4 of 5, D.O. Series No. AF 1439/26. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 5296, Date: 10 NOV. 59. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

Excitation-contraction coupling in zebrafish ventricular myocardium is regulated by trans-sarcolemmal Ca2+ influx and sarcoplasmic reticulum Ca2+ release.

PubMed

Haustein, Moritz; Hannes, Tobias; Trieschmann, Jan; Verhaegh, Rabea; Köster, Annette; Hescheler, Jürgen; Brockmeier, Konrad; Adelmann, Roland; Khalil, Markus

2015-01-01

Zebrafish (Danio rerio) have become a popular model in cardiovascular research mainly due to identification of a large number of mutants with structural defects. In recent years, cardiomyopathies and other diseases influencing contractility of the heart have been studied in zebrafish mutants. However, little is known about the regulation of contractility of the zebrafish heart on a tissue level. The aim of the present study was to elucidate the role of trans-sarcolemmal Ca(2+)-flux and sarcoplasmic reticulum Ca(2+)-release in zebrafish myocardium. Using isometric force measurements of fresh heart slices, we characterised the effects of changes of the extracellular Ca(2+)-concentration, trans-sarcolemmal Ca(2+)-flux via L-type Ca(2+)-channels and Na(+)-Ca(2+)-exchanger, and Ca(2+)-release from the sarcoplasmic reticulum as well as beating frequency and β-adrenergic stimulation on contractility of adult zebrafish myocardium. We found an overall negative force-frequency relationship (FFR). Inhibition of L-type Ca(2+)-channels by verapamil (1 μM) decreased force of contraction to 22 ± 7% compared to baseline (n=4, p<0.05). Ni(2+) was the only substance to prolong relaxation (5 mM, time after peak to 50% relaxation: 73 ± 3 ms vs. 101 ± 8 ms, n=5, p<0.05). Surprisingly though, inhibition of the sarcoplasmic Ca(2+)-release decreased force development to 54 ± 3% in ventricular (n=13, p<0.05) and to 52 ± 8% in atrial myocardium (n=5, p<0.05) suggesting a substantial role of SR Ca(2+)-release in force generation. In line with this finding, we observed significant post pause potentiation after pauses of 5 s (169 ± 7% force compared to baseline, n=8, p<0.05) and 10 s (198 ± 9% force compared to baseline, n=5, p<0.05) and mildly positive lusitropy after β-adrenergic stimulation. In conclusion, force development in adult zebrafish ventricular myocardium requires not only trans-sarcolemmal Ca2+-flux, but also intact sarcoplasmic reticulum Ca(2+)-cycling. In contrast to mammals, FFR is strongly negative in the zebrafish heart. These aspects need to be considered when using zebrafish to model human diseases of myocardial contractility.

Excitation-Contraction Coupling in Zebrafish Ventricular Myocardium Is Regulated by Trans-Sarcolemmal Ca2+ Influx and Sarcoplasmic Reticulum Ca2+ Release

PubMed Central

Trieschmann, Jan; Verhaegh, Rabea; Köster, Annette; Hescheler, Jürgen; Brockmeier, Konrad; Adelmann, Roland; Khalil, Markus

2015-01-01

Zebrafish (Danio rerio) have become a popular model in cardiovascular research mainly due to identification of a large number of mutants with structural defects. In recent years, cardiomyopathies and other diseases influencing contractility of the heart have been studied in zebrafish mutants. However, little is known about the regulation of contractility of the zebrafish heart on a tissue level. The aim of the present study was to elucidate the role of trans-sarcolemmal Ca2+-flux and sarcoplasmic reticulum Ca2+-release in zebrafish myocardium. Using isometric force measurements of fresh heart slices, we characterised the effects of changes of the extracellular Ca2+-concentration, trans-sarcolemmal Ca2+-flux via L-type Ca2+-channels and Na+-Ca2+-exchanger, and Ca2+-release from the sarcoplasmic reticulum as well as beating frequency and β-adrenergic stimulation on contractility of adult zebrafish myocardium. We found an overall negative force-frequency relationship (FFR). Inhibition of L-type Ca2+-channels by verapamil (1 μM) decreased force of contraction to 22±7% compared to baseline (n=4, p<0.05). Ni2+ was the only substance to prolong relaxation (5 mM, time after peak to 50% relaxation: 73±3 ms vs. 101±8 ms, n=5, p<0.05). Surprisingly though, inhibition of the sarcoplasmic Ca2+-release decreased force development to 54±3% in ventricular (n=13, p<0.05) and to 52±8% in atrial myocardium (n=5, p<0.05) suggesting a substantial role of SR Ca2+-release in force generation. In line with this finding, we observed significant post pause potentiation after pauses of 5 s (169±7% force compared to baseline, n=8, p<0.05) and 10 s (198±9% force compared to baseline, n=5, p<0.05) and mildly positive lusitropy after β-adrenergic stimulation. In conclusion, force development in adult zebrafish ventricular myocardium requires not only trans-sarcolemmal Ca2+-flux, but also intact sarcoplasmic reticulum Ca2+-cycling. In contrast to mammals, FFR is strongly negative in the zebrafish heart. These aspects need to be considered when using zebrafish to model human diseases of myocardial contractility. PMID:25938412

3. NORTH FRONT, BULLET GLASS OBSERVATION WINDOWS FACE SLED TRACK. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. NORTH FRONT, BULLET GLASS OBSERVATION WINDOWS FACE SLED TRACK. - Edwards Air Force Base, South Base Sled Track, Instrumentation & Control Building, South of Sled Track, Station "50" area, Lancaster, Los Angeles County, CA

Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading

NASA Technical Reports Server (NTRS)

Ingalls, C. P.; Warren, G. L.; Armstrong, R. B.; Hamilton, S. L. (Principal Investigator)

1999-01-01

The objective of this study was to determine whether altered intracellular Ca(2+) handling contributes to the specific force loss in the soleus muscle after unloading and/or subsequent reloading of mouse hindlimbs. Three groups of female ICR mice were studied: 1) unloaded mice (n = 11) that were hindlimb suspended for 14 days, 2) reloaded mice (n = 10) that were returned to their cages for 1 day after 14 days of hindlimb suspension, and 3) control mice (n = 10) that had normal cage activity. Maximum isometric tetanic force (P(o)) was determined in the soleus muscle from the left hindlimb, and resting free cytosolic Ca(2+) concentration ([Ca(2+)](i)), tetanic [Ca(2+)](i), and 4-chloro-m-cresol-induced [Ca(2+)](i) were measured in the contralateral soleus muscle by confocal laser scanning microscopy. Unloading and reloading increased resting [Ca(2+)](i) above control by 36% and 24%, respectively. Although unloading reduced P(o) and specific force by 58% and 24%, respectively, compared with control mice, there was no difference in tetanic [Ca(2+)](i). P(o), specific force, and tetanic [Ca(2+)](i) were reduced by 58%, 23%, and 23%, respectively, in the reloaded animals compared with control mice; however, tetanic [Ca(2+)](i) was not different between unloaded and reloaded mice. These data indicate that although hindlimb suspension results in disturbed intracellular Ca(2+) homeostasis, changes in tetanic [Ca(2+)](i) do not contribute to force deficits. Compared with unloading, 24 h of physiological reloading in the mouse do not result in further changes in maximal strength or tetanic [Ca(2+)](i).

Effect of Interfacial Bonding on the Strength of Adhesion of Elastomers, I. Self-Adhesion.

DTIC Science & Technology

1981-01-30

Arlingon, VA 22217 Edwards AFB, CA 93523 Attn: Mr. 0. Siegel Attn: Dr. F. Roberto Office of Naval Research 1 AFSC Western Office Andrews AFB, Code DLFP...San Francisco Area Office space Sciences One Hallidie Plaza Suite 601 Bolling Air Force Base San Francisco, CA 94102 Washington, DC 20332 Attn: Or. P. A

43. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Photographic copy of photograph (ca. 1962, original print in possession of Peter Kiewit Sons' Co., Omaha, Nebraska) Photographer unknown. View of launch closure, launch closure apron at left, personnel access hatch open at right - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

Environmental Assessment for Implementation of the Installation Development Plan at Edwards Air Force Base, California

DTIC Science & Technology

2017-05-01

natural gas and oil), solid waste, trees and wood products, and also as a result of certain chemical reactions (e.g., manufacture of cement). CO2 is......CA 93309 San Manuel Band of Mission Indians 26569 Community Center Drive Highland, CA 92346 Charles F. Wood , Chairman Chemehuevi Indian Tribe

46. BASE OF UMBILICAL MAST FROM UMBILICAL MAST TRENCH. ERECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. BASE OF UMBILICAL MAST FROM UMBILICAL MAST TRENCH. ERECTION AND RETRACTION CYLINDERS BETWEEN MAST AND TRENCH WALL. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Mechanisms underlying hypothermia-induced cardiac contractile dysfunction.

PubMed

Han, Young-Soo; Tveita, Torkjel; Prakash, Y S; Sieck, Gary C

2010-03-01

Rewarming patients after profound hypothermia may result in acute heart failure and high mortality (50-80%). However, the underlying pathophysiological mechanisms are largely unknown. We characterized cardiac contractile function in the temperature range of 15-30 degrees C by measuring the intracellular Ca(2+) concentration ([Ca(2+)](i)) and twitch force in intact left ventricular rat papillary muscles. Muscle preparations were loaded with fura-2 AM and electrically stimulated during cooling at 15 degrees C for 1.5 h before being rewarmed to the baseline temperature of 30 degrees C. After hypothermia/rewarming, peak twitch force decreased by 30-40%, but [Ca(2+)](i) was not significantly altered. In addition, we assessed the maximal Ca(2+)-activated force (F(max)) and Ca(2+) sensitivity of force in skinned papillary muscle fibers. F(max) was decreased by approximately 30%, whereas the pCa required for 50% of F(max) was reduced by approximately 0.14. In rewarmed papillary muscle, both total cardiac troponin I (cTnI) phosphorylation and PKA-mediated cTnI phosphorylation at Ser23/24 were significantly increased compared with controls. We conclude that after hypothermia/rewarming, myocardial contractility is significantly reduced, as evidenced by reduced twitch force and F(max). The reduced myocardial contractility is attributed to decreased Ca(2+) sensitivity of force rather than [Ca(2+)](i) itself, resulting from increased cTnI phosphorylation.

KIDS Nuclear Energy Density Functional: 1st Application in Nuclei

NASA Astrophysics Data System (ADS)

Gil, Hana; Papakonstantinou, Panagiota; Hyun, Chang Ho; Oh, Yongseok

We apply the KIDS (Korea: IBS-Daegu-Sungkyunkwan) nuclear energy density functional model, which is based on the Fermi momentum expansion, to the study of properties of lj-closed nuclei. The parameters of the model are determined by the nuclear properties at the saturation density and theoretical calculations on pure neutron matter. For applying the model to the study of nuclei, we rely on the Skyrme force model, where the Skyrme force parameters are determined through the KIDS energy density functional. Solving Hartree-Fock equations, we obtain the energies per particle and charge radii of closed magic nuclei, namely, 16O, 28O, 40Ca, 48Ca, 60Ca, 90Zr, 132Sn, and 208Pb. The results are compared with the observed data and further improvement of the model is shortly mentioned.

6. SOUTH SIDE, DETAIL OF BULLET GLASS WINDOWS AT GROUND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. SOUTH SIDE, DETAIL OF BULLET GLASS WINDOWS AT GROUND LEVEL. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

2. BUILDING 0521, SOUTH REAR AND EAST SIDE. Looking to ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. BUILDING 0521, SOUTH REAR AND EAST SIDE. Looking to northwest from access road. - Edwards Air Force Base, South Base Sled Track, Earth Covered Bunker Types, North of Sled Track, Lancaster, Los Angeles County, CA

28. "CONSTRUCTION PHASING, STATION '0' AREA." Specifications No. OC15775, Drawing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. "CONSTRUCTION PHASING, STATION '0' AREA." Specifications No. OC1-57-75, Drawing No. AF-45-02-19, sheet 3 of 5, D.O. Series No. AF 1439/25, Rev. B. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 5296 Rev. B, Date: 11/13/59. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

6. COMPRESSOR CONTROL PANELS: AT LEFT, 6,000 P.S.I. PANEL, CIRCA ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. COMPRESSOR CONTROL PANELS: AT LEFT, 6,000 P.S.I. PANEL, CIRCA 1957; AT RIGHT, FACING CAMERA, 10,000 P.S.I. PANEL. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Helium Compression Plant, Test Area 1-115, intersection of Altair & Saturn Boulevards, Boron, Kern County, CA

1. GENERAL VIEW OF WEST FACE OF ENTRY CONTROL POINT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF WEST FACE OF ENTRY CONTROL POINT (BLDG. 768) SHOWING RELATIVE POSITION TO TECHNICAL SUPPORT BUILDING (BLDG. 762/762A) AND SLC-3 AIR FORCE BUILDING (BLDG. 761) - Vandenberg Air Force Base, Space Launch Complex 3, Entry Control Point, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

1. TERMINAL ROOM, INTERIOR, SHOP LEVEL, SHOWING FIRE EXTINGUISHING SYSTEM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. TERMINAL ROOM, INTERIOR, SHOP LEVEL, SHOWING FIRE EXTINGUISHING SYSTEM PIPES AND VALVES AT LEFT. Looking southeast from entrance to terminal room. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

RP1 (KEROSENE) STORAGE TANKS ON HILLSIDE EAST OF TEST STAND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

RP1 (KEROSENE) STORAGE TANKS ON HILLSIDE EAST OF TEST STAND 1-B. THIS TANK FARM SERVES BOTH TEST STANDS 1-A AND 1-B - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Combined Fuel Storage Tank Farm, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

7. CABLE RACK, MEZZANINE LEVEL, INTERIOR OF TEST STAND 1A. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. CABLE RACK, MEZZANINE LEVEL, INTERIOR OF TEST STAND 1A. Looking north from north end of the cable tunnel leading toward Control Center. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

21. VALVES, GAUGES, AND SEVERAL TYPES OF LIGHTING ALONG ROAD ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. VALVES, GAUGES, AND SEVERAL TYPES OF LIGHTING ALONG ROAD AT SOUTH REAR OF TEST STAND 1-A. RP1 TANK FARM IN MIDDLE DISTANCE. Looking northeast. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

15. DETAIL SHOWING HYDROGEN (LEFT) AND OXYGEN (RIGHT) SPHERICAL TANKS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. DETAIL SHOWING HYDROGEN (LEFT) AND OXYGEN (RIGHT) SPHERICAL TANKS ON RUN LINE DECK, THIRD LEVEL. DARK TONED PIPING IS THE FIRE EXTINGUISHING SYSTEM. Looking south southwest. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

5. WEST SIDE, ALSO SHOWING INSTRUMENTATION AND CONTROL BUILDING (BLDG. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. WEST SIDE, ALSO SHOWING INSTRUMENTATION AND CONTROL BUILDING (BLDG. 8668) IN MIDDLE DISTANCE AT LEFT, AND TEST AREAS 1-120 AND 1-125 BEYOND. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-4, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Building 933935, oblique view to southwest showing, left to right, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Building 933-935, oblique view to southwest showing, left to right, rear doors to building 933, 934, 935, 90 mm lens. Building 934 in the center of complex. - Travis Air Force Base, Nuclear Weapons Assembly Plant 3, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

A physiological basis for variation in the contractile properties of isolated rat heart.

PubMed Central

Lin, L E; McClellan, G; Weisberg, A; Winegrad, S

1991-01-01

1. The maximum Ca(2+)-activated force, maximum velocity of unloaded shortening and both Ca(2+)- and actin-activated ATPase activities of myosin have been measured in detergent-skinned preparations of isolated bundles of rat right ventricle after exposure of the intact tissue to different conditions of superfusion, mechanical activity and temperature. 2. Maximum Ca(2+)-activated force per unit cross-sectional area decreases with increasing cross-sectional area, and, in the absence of electrical stimulation, with the duration of superfusion. Maximum velocity of unloaded shortening is not influenced by these differences. 3. Actin-activated ATPase activity of myosin decreases as cross-sectional area increases and duration of superfusion increases, but the extent of the decrease in enzymatic activity is less than that of developed force. Ca(2+)-activated ATPase activity is independent of these differences. 4. Actin-activated ATPase activity in cryostatic sections of quickly frozen tissue is not uniform across the transverse section. In thin bundles, it is highest in the centre and lowest at the edge of the section, which correspond, respectively, to the centre and the surface of the tissue bundle. Exposure of the tissue section to 1 microM-cyclic AMP increases the actin-activated ATPase activity of myosin with the largest increase in activity occurring at or near the surface of the bundle. 5. Ca(2+)-activated ATPase activity of myosin is uniform across the transverse section and is not changed by cyclic AMP. 6. Electrical stimulation, elevated Ca2+ concentration in the superfusion medium, or isoprenaline partially or completely reverse the decline in maximum Ca(2+)-activated force produced by prolonged superfusion of the bundle before its skinning. 7. These observations are similar in many ways to those made on frog skeletal muscles by Elzinga, Howarth, Rull, Wilson & Woledge (1989a). An explanation based on the existence of a physiological mechanism for regulating the properties of force generators is proposed. Regulation of the attachment of the cross-bridge to an actin filament may be the basis for the regulatory mechanism. Images Fig. 4 Fig. 7 PMID:1667804

21. Photographic copy of a keyed site plan for North ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Photographic copy of a keyed site plan for North Base: Military Construction, Muroc Flight Test Base, Muroc, California; General Layout Plan, December 1944. Reproduced from the holdings of the National Archives, Pacific Southwest Region - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

Differential effects of arginine, glutamate and phosphoarginine on Ca(2+)-activation properties of muscle fibres from crayfish and rat.

PubMed

Jame, David W; West, Jan M; Dooley, Philip C; Stephenson, D George

2004-01-01

The effects of two amino acids, arginine which has a positively charged side-chain and glutamate which has a negatively charged side-chain on the Ca2+-activation properties of the contractile apparatus were examined in four structurally and functionally different types of skeletal muscle; long- and short-sarcomere fibres from the claw muscle of the yabby (a freshwater decapod crustacean), and fast- and slow-twitch fibres from limb muscles of the rat. Single skinned fibres were activated in carefully balanced solutions of different pCa (-log10[Ca2+]) that either contained the test solute ("test") or not ("control"). The effect of phosphoarginine, a phosphagen that bears a nett negative charge, was also compared to the effects of arginine. Results show that (i) arginine (33-36 mmol l(-1)) significantly shifted the force-pCa curve by 0.08-0.13 pCa units in the direction of increased sensitivity to Ca2+-activated contraction in all fibre types; (ii) phosphoarginine (9-10 mmol l(-1)) induced a significant shift of the force-pCa curve by 0.18-0.24 pCa units in the direction of increased sensitivity to Ca2+ in mammalian fast- and slow-twitch fibres, but had no significant effects on the force-pCa relation in either long- or short-sarcomere crustacean fibres; (iii) glutamate (36-40 mmol l(-1)), like arginine affected the force-pCa relation of all fibre types investigated, but in the opposite direction, causing a significant decrease in the sensitivity to Ca2+-activated contraction by 0.08-0.19 pCa units; (iv) arginine, phosphoarginine and glutamate had little or no effect on the maximum Ca2+-activated force of crustacean and mammalian fibres. The results suggest that the opposing effects of glutamate and arginine are not related to simply their charge structure, but must involve complex interactions between these molecules, Ca2+ and the regulatory and other myofibrillar proteins.

Mass Spectrometric Thermal Decomposition and Ultraviolet Irradiation Studies of Some Azido and Nitrato Polymeric Binders.

DTIC Science & Technology

1982-09-01

Edwards AFB, CA 93523 Attn: Mr. D. Siegel Attn: Dr. F. Roberto Office of Naval Research 1 AFSC Western Office Andrews AFB, Code DLFP 1030 East Green...Office space Sciences One Hallidie Plaza Suite 601 Bolling Air Force Base San Francisco, CA 94102 Washing.on, DC 20332 Attn: Dr. P. A. Miller Attn: Dr

19. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photographic copy of photograph (ca. 1962, original print in possession of Peter Kiewit Sons' Co., Omaha, Nebraska) Photographer unknown. Road signs for Alpha Flight Launch Facility sites 8-11 and Bravo Flight Launch Facility sites 2 and 11 - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

6. INTERIOR, ORIGINAL BLOCKHOUSE SECTION OF BUILDING 0512, NORTH WALL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. INTERIOR, ORIGINAL BLOCKHOUSE SECTION OF BUILDING 0512, NORTH WALL FACING TEST TRACK. - Edwards Air Force Base, South Base Sled Track, Instrumentation & Control Building, South of Sled Track, Station "50" area, Lancaster, Los Angeles County, CA

Credit BG. Interior of Deluge Water Booster Station displaying highcapacity ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. Interior of Deluge Water Booster Station displaying high-capacity electrically driven water pumps for fire fighting service - Edwards Air Force Base, North Base, Deluge Water Booster Station, Northeast of A Street, Boron, Kern County, CA

3. BUILDING 0503, NORTH FRONT AND WEST SIDE, WITH LOADING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. BUILDING 0503, NORTH FRONT AND WEST SIDE, WITH LOADING DOCK AND GABLE ROOFED SHED. - Edwards Air Force Base, South Base Sled Track, Earth Covered Bunker Types, North of Sled Track, Lancaster, Los Angeles County, CA

Credit BG. Northwest and southwest facades of Administration Building for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. Northwest and southwest facades of Administration Building for Building 4505 area. Construction began on this building in 1967 - Edwards Air Force Base, North Base, Administration Building, Northeast of A Street, Boron, Kern County, CA

Determinants of relaxation rate in rabbit skinned skeletal muscle fibres

PubMed Central

Luo, Ye; Davis, Jonathan P; Smillie, Lawrence B; Rall, Jack A

2002-01-01

The influence of Ca2+-activated force, the rate of dissociation of Ca2+ from troponin C (TnC) and decreased crossbridge detachment rate on the time course of relaxation induced by flash photolysis of diazo-2 in rabbit skinned psoas fibres was investigated at 15 °C. The rate of relaxation increased as the diazo-2 chelating capacity (i.e. free [diazo-2]/free [Ca2+]) increased. At a constant diazo-2 chelating capacity, the rate of relaxation was independent of the pre-photolysis Ca2+-activated force in the range 0.3-0.8 of maximum isometric force. A TnC mutant that exhibited increased Ca2+ sensitivity caused by a decreased Ca2+ dissociation rate in solution (M82Q TnC) also increased the Ca2+ sensitivity of steady-state force and decreased the rate of relaxation in fibres by approximately twofold. In contrast, a TnC mutant with decreased Ca2+ sensitivity caused by an increased Ca2+ dissociation rate in solution (NHdel TnC) decreased the Ca2+ sensitivity of steady-state force but did not accelerate relaxation. Decreasing the rate of crossbridge kinetics by reducing intracellular inorganic phosphate concentration ([Pi]) slowed relaxation by approximately twofold and led to two phases of relaxation, a slow linear phase followed by a fast exponential phase. In fibres, M82Q TnC further slowed relaxation in low [Pi] conditions by approximately twofold, whereas NHdel TnC had no significant effect on relaxation. These results are consistent with the interpretation that the Ca2+-dissociation rate and crossbridge detachment rate are similar in fast-twitch skeletal muscle, such that decreasing either rate slows relaxation, but accelerating Ca2+ dissociation has little effect on relaxation. PMID:12482894

Photographic copy of photograph, view of rail launcher used for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, view of rail launcher used for 'Baby Corporal E' missiles on 6 and 7 May 1946 at JPL-Muroc Army Air Base (later Edwards Air Force Base) (This launcher was also used for 'Baby WAC' missiles at Goldstone, Fort Irwin, California in 1945). Photocopy of 35mm photograph made in December 1994, looking west with Test Stand 'A' immediately behind the rail launcher. - Jet Propulsion Laboratory Edwards Facility, Edwards Air Force Base, Boron, Kern County, CA

27. "SITE PLAN." Specifications No. OC15775, Drawing No. AF600915, sheet ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. "SITE PLAN." Specifications No. OC1-57-75, Drawing No. AF-60-09-15, sheet 1 of 96, D.O. Series No. AF 1394/20, Rev. B. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 5296 Rev. B, Date: 11/17/59. Site plan of 20,000-foot track, including construction phasing notes. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

29. "TEST TRACK, STATION '0' THROUGH '200' AREA." Specifications No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. "TEST TRACK, STATION '0' THROUGH '200' AREA." Specifications No. ENG-OC-1-57-75, Drawing No. AF-6009-15, sheet 53 of 96, D.O. Series No. AF 1394/73, Rev. C. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 5296 Rev. C, Date: 19 NOV 59. Drawing includes plan, section, and details of track. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

Hydrogen peroxide modulates Ca2+-activation of single permeabilized fibres from fast- and slow-twitch skeletal muscles of rats.

PubMed

Plant, D R; Lynch, G S; Williams, D A

2000-01-01

We examined the effects of redox modulation on single membrane-permeabilized fibre segments from the fast-twitch extensor digitorum longus (EDL) and slow-twitch soleus muscles of adult rats to determine whether the contractile apparatus was the redox target responsible for the increased contractility of muscles exposed to low concentrations of H2O2. The effects of H2O2 on maximum Ca2+-activated force were dose-dependent with 30 min exposure to 5 mM H2O2 causing a progressive decrease by 22+/-3 and 13+/-2% in soleus and EDL permeabilized muscle fibres, respectively. Lower concentrations of exogenous H2O2 (100 microM and 1 mM) had no effect on maximum Ca2+-activated force. Subsequent exposure to the reductant dithiothreitol (DTT, 10 mM, 10 min) fully reversed the H2O2-induced depression of force in EDL, but not in soleus muscle fibres. Incubation with DTT alone for 10 min did not alter Ca2+-activated force in either soleus or EDL muscle fibres. The sensitivity of the contractile filaments to Ca2+ (pCa50) was not altered by exposure to any concentration of exogenous H2O2. However, all concentrations of H2O2 diminished the Hill coefficient in permeabilized fibres from the EDL muscle, indicating that the cooperativity of Ca2+ binding to troponin is altered. H2O2 (5 mM) did not affect rigor force, which indicates that the number of crossbridges participating in contraction was not reduced. In conclusion, H2O2 may reduce the maximum Ca2+ activated force production in skinned muscle fibres by decreasing the force per crossbridge.

4. TEST AREA 1120 OVERVIEW, TEST AREA 1115 IN MIDDLE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. TEST AREA 1-120 OVERVIEW, TEST AREA 1-115 IN MIDDLE DISTANCE, AND TEST AREA 1-110 IN FAR DISTANCE AT EXTREME LEFT. ROGERS DRY LAKE AND THE HANGARS AT MAIN BASE ARE VISIBLE IN THE FAR RIGHT DISTANCE. TEST STANDS 2-A AND 1-A ARE NEAREST THE CAMERA. Looking west southwest. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

7. CONTROL AND EQUIPMENT ROOM INTERIOR. Looking to southwest corner ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. CONTROL AND EQUIPMENT ROOM INTERIOR. Looking to southwest corner and entrance to cable tunnel. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

3. NORTHEAST SIDE, WITH A SINGLE BULLET GLASS WINDOW AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. NORTHEAST SIDE, WITH A SINGLE BULLET GLASS WINDOW AND SOUTHEAST REAR WITH ENTRY DOOR. - Edwards Air Force Base, South Base Sled Track, Observation Block House, Station "O" area, east end of Sled Track, Lancaster, Los Angeles County, CA

7. PHOTOCOPY OF DRAWING (UNDATED PLAN AND SCHEDULE DRAWING BY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. PHOTOCOPY OF DRAWING (UNDATED PLAN AND SCHEDULE DRAWING BY THE DEPARTMENT OF THE AIR FORCE, SPACE AND MISSILE TEST CENTER) MATERIAL SPECIFICATIONS AND GENERAL NOTES FOR INTERIOR FINISHING FOR BUILDING 762-A, SHEET A4 - Vandenberg Air Force Base, Space Launch Complex 3, Technical Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Conservative Bin-to-Bin Fractional Collisions

DTIC Science & Technology

2016-06-28

BIN FRACTIONAL COLLISIONS Robert Martin ERC INC., SPACECRAFT PROPULSION BRANCH AIR FORCE RESEARCH LABORATORY EDWARDS AIR FORCE BASE, CA USA 30th...IMPORTANCE OF COLLISION PHYSICS Important Collisions in Spacecraft Propulsion : Discharge and Breakdown in FRC Collisional Radiative Cooling/Ionization...UNLIMITED; PA #16326 3 / 18 IMPORTANCE OF COLLISION PHYSICS Important Collisions in Spacecraft Propulsion : Discharge and Breakdown in FRC Collisional

2. SOUTHEAST SIDE AND NORTHEAST REAR. SHOP BUILDING IN DISTANCE. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. SOUTHEAST SIDE AND NORTHEAST REAR. SHOP BUILDING IN DISTANCE. NOTE CONCRETE PROTECTION SLAB FOR UNDERGROUND CONTROL ROOM AND ESCAPE HATCH ON GROUND AT RIGHT MIDDLE DISTANCE. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Firing Control Building, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

5. FLAME DEFLECTOR, COMPLETE X15 VEHICLE TEST STAND. Looking east. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. FLAME DEFLECTOR, COMPLETE X-15 VEHICLE TEST STAND. Looking east. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

5. PILOTS KNIGHT, RUSHWORTH, ENGLE, THOMPSON, DANA, AND McKAY STANDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. PILOTS KNIGHT, RUSHWORTH, ENGLE, THOMPSON, DANA, AND McKAY STANDING AT THE NOSE OF X-15 NO. 66671. - Edwards Air Force Base, X-15 Engine Test Complex, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice.

PubMed

Li, Zhitao; Singh, Sonal; Suryavanshi, Santosh V; Ding, Wengang; Shen, Xiaoxu; Wijaya, Cori S; Gao, Wei Dong; McConnell, Bradley K

2017-07-15

Gravin (AKAP12) is an A-kinase-anchoring-protein that scaffolds protein kinase A (PKA), β 2 -adrenergic receptor (β 2 -AR), protein phosphatase 2B and protein kinase C. Gravin facilitates β 2 -AR-dependent signal transduction through PKA to modulate cardiac excitation-contraction coupling and its removal positively affects cardiac contraction. Trabeculae from the right ventricles of gravin mutant (gravin-t/t) mice were employed for force determination. Simultaneously, corresponding intracellular Ca 2+ transient ([Ca 2+ ] i ) were measured. Twitch force (T f )-interval relationship, [Ca 2+ ] i -interval relationship, and the rate of decay of post-extrasysolic potentiation (R f ) were also obtained. Western blot analysis were performed to correlate sarcomeric protein expression with alterations in calcium cycling between the WT and gravin-t/t hearts. Gravin-t/t muscles had similar developed force compared to WT muscles despite having lower [Ca 2+ ] i at any given external Ca 2+ concentration ([Ca 2+ ] o ). The time to peak force and peak [Ca 2+ ] i were slower and the time to 75% relaxation was significantly prolonged in gravin-t/t muscles. Both T f -interval and [Ca 2+ ] i -interval relations were depressed in gravin-t/t muscles. R f , however, did not change. Furthermore, Western blot analysis revealed decreased ryanodine receptor (RyR2) phosphorylation in gravin-t/t hearts. Gravin-t/t cardiac muscle exhibits increased force development in responsiveness to Ca 2+ . The Ca 2+ cycling across the SR appears to be unaltered in gravin-t/t muscle. Our study suggests that gravin is an important component of cardiac contraction regulation via increasing myofilament sensitivity to calcium. Further elucidation of the mechanism can provide insights to role of gravin if any in the pathophysiology of impaired contractility. Copyright © 2017 Elsevier B.V. All rights reserved.

The Ca2+ sensitizer CK‐2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle

PubMed Central

Cheng, Arthur J.; Hartman, James J.; Hinken, Aaron C.; Lee, Ken; Durham, Nickie; Russell, Alan J.; Malik, Fady I.; Westerblad, Håkan; Jasper, Jeffrey R.

2017-01-01

Key points We report that the small molecule CK‐2066260 selectively slows the off‐rate of Ca2 + from fast skeletal muscle troponin, leading to increased myofibrillar Ca2 + sensitivity in fast skeletal muscle.Rodents dosed with CK‐2066260 show increased hindlimb muscle force and power in response to submaximal rates of nerve stimulation in situ.CK‐2066260 has no effect on free cytosolic [Ca2 +] during contractions of isolated muscle fibres.We conclude that fast skeletal muscle troponin sensitizers constitute a potential therapy to address an unmet need of improving muscle function in conditions of weakness and premature muscle fatigue. Abstract Skeletal muscle dysfunction occurs in many diseases and can lead to muscle weakness and premature muscle fatigue. Here we show that the fast skeletal troponin activator, CK‐2066260, counteracts muscle weakness by increasing troponin Ca2+ affinity, thereby increasing myofibrillar Ca2+ sensitivity. Exposure to CK‐2066260 resulted in a concentration‐dependent increase in the Ca2+ sensitivity of ATPase activity in isolated myofibrils and reconstituted hybrid sarcomeres containing fast skeletal muscle troponin C. Stopped‐flow experiments revealed a ∼2.7‐fold decrease in the Ca2+ off‐rate of isolated troponin complexes in the presence of CK‐2066260 (6 vs. 17 s−1 under control conditions). Isolated mouse flexor digitorum brevis fibres showed a rapidly developing, reversible and concentration‐dependent force increase at submaximal stimulation frequencies. This force increase was not accompanied by any changes in the free cytosolic [Ca2+] or its kinetics. CK‐2066260 induced a slowing of relaxation, which was markedly larger at 26°C than at 31°C and could be linked to the decreased Ca2+ off‐rate of troponin C. Rats dosed with CK‐2066260 showed increased hindlimb isometric and isokinetic force in response to submaximal rates of nerve stimulation in situ producing significantly higher absolute forces at low isokinetic velocities, whereas there was no difference in force at the highest velocities. Overall muscle power was increased and the findings are consistent with a lack of effect on crossbridge kinetics. In conclusion, CK‐2066260 acts as a fast skeletal troponin activator that may be used to increase muscle force and power in conditions of muscle weakness. PMID:27869319

2. Credit USAF, ca. 1945. Original housed in the Records ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Credit USAF, ca. 1945. Original housed in the Records of the Defense Intelligence Agency. Record Group 373. National Archives. Cartographic and Architectural Branch. Washington, D.C. Oblique aerial photo 16PS5M79-1-0-48-4:3:1152:12:120003500N11745W looking roughly north northeast across North Base from a position over Rogers Dry Lake. Largest structures are hangars, beginning with Building 4305 (Unicon Portable Hangar) at view center and continuing to right with Buildings 4401 and 4402 (Type HANG-N-A hangars), with Building 4505 (Type HANG-P-A hangar) in the distance. Bachelor Officers' Quarters known as the "Desert Rat Hotel" (T-l) was located adjacent to Building 4305. - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

22. Photographic copy of an asconstructed site plan for North ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Photographic copy of an as-constructed site plan for North Base: Job No. Muroc AFB A-52, War Department-Corps of Engineers, Office of the District Engineer, Los Angeles, California: Muroc Air Force Base, Muroc, California; Additonal Sprinkler Facilities, Test Base, Electrical Distribution & Pump House No. 3 Details, Sheet No. 14 of 17, October 1950. This drawing gives the contemporary temporary building numbers (T-xx) for all structures at North Base in 1950 Reproduced from the holdings of the National Archives, Pacific Southwest Region - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

Sections. March Air Force Base, Riverside, California, Combat Operations Center, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Sections. March Air Force Base, Riverside, California, Combat Operations Center, Combat Operations Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 14, approved March, 1962; specifications no. ENG-04-353-62-66; D.O. series AW 1596/15, Rev. "A"; file drawer 1290. Last revised 3 October 1966. Scale one-eighth inch to one foot. 30x36 inches. pencil on paper - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

Utility Building Plan, elevations and sections. March Air Force Base, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Utility Building Plan, elevations and sections. March Air Force Base, Riverside, California, COmbat Operations Center, Utility Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 57, approved March, 1962; specifications no. ENG-04-353-62-66; D.O. series AW 1596/57, Rev. "B"; file drawer 1290. Last revised 3 October 1966 "drawings updated." Various scales. 29 x 41 inches. pencil on paper - March Air Force Base, Strategic Air Command, Utility Building, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

43. VIEW OF NORTHWEST CORNER OF STATION 111 WEST ANTEROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. VIEW OF NORTHWEST CORNER OF STATION 111 WEST ANTEROOM SHOWING HYDRAULIC ACTUATOR ARM (LEFT) AND PUMP (RIGHT) FOR WEST ENVIRONMENTAL DOOR ON NORTH FACE OF MST. NOTE LOCATION NEAR FLOOR RATHER THAN NEAR CEILING AS ON STATION 85.5 (CA-133-1-C-38). - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Cross-bridge blocker BTS permits direct measurement of SR Ca2+ pump ATP utilization in toadfish swimbladder muscle fibers.

PubMed

Young, Iain S; Harwood, Claire L; Rome, Lawrence C

2003-10-01

Because the major processes involved in muscle contraction require rapid utilization of ATP, measurement of ATP utilization can provide important insights into the mechanisms of contraction. It is necessary, however, to differentiate between the contribution made by cross-bridges and that of the sarcoplasmic reticulum (SR) Ca2+ pumps. Specific and potent SR Ca2+ pump blockers have been used in skinned fibers to permit direct measurement of cross-bridge ATP utilization. Up to now, there was no analogous cross-bridge blocker. Recently, N-benzyl-p-toluene sulfonamide (BTS) was found to suppress force generation at micromolar concentrations. We tested whether BTS could be used to block cross-bridge ATP utilization, thereby permitting direct measurement of SR Ca2+ pump ATP utilization in saponin-skinned fibers. At 25 microM, BTS virtually eliminates force and cross-bridge ATP utilization (both <4% of control value). By taking advantage of the toadfish swimbladder muscle's unique right shift in its force-Ca2+ concentration ([Ca2+]) relationship, we measured SR Ca2+ pump ATP utilization in the presence and absence of BTS. At 25 microM, BTS had no effect on SR pump ATP utilization. Hence, we used BTS to make some of the first direct measurements of ATP utilization of intact SR over a physiological range of [Ca2+]at 15 degrees C. Curve fits to SR Ca2+ pump ATP utilization vs. pCa indicate that they have much lower Hill coefficients (1.49) than that describing cross-bridge force generation vs. pCa (approximately 5). Furthermore, we found that BTS also effectively eliminates force generation in bundles of intact swimbladder muscle, suggesting that it will be an important tool for studying integrated SR function during normal motor behavior.

Credit USAF, 7 September 1945. Original housed in the Muroc ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit USAF, 7 September 1945. Original housed in the Muroc Flight Test Base, Unit History, 1 September 1942 - 30 June 1945. Alfred F. Simpson Historical Research Agency. United States Air Force. Maxwell AFB, Alabama. Photo captioned "Oblique view of Recreation Hall/Chapel Bldg. T73." Movies on marquee were "Why Girls Leave Home" and "Blazing the Western Trail." View looks west from camera position across E Street - Edwards Air Force Base, North Base, Recreation Hall & Chapel T-73, E Street near North Base Road, Boron, Kern County, CA

Credit BG. View looks southwest (236°) at the warehouse's southeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. View looks southwest (236°) at the warehouse's southeast and northeast facades. This building retains its original World War II era materials and appearance - Edwards Air Force Base, North Base, Warehouse, Second & C Streets, Boron, Kern County, CA

3. Credit BG. Interior view looks northeast (46°) at fire ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Credit BG. Interior view looks northeast (46°) at fire pumps, valves, and emergency generator (powered by an internal combustion engine). - Edwards Air Force Base, North Base, Deluge Water Pumping Station, Near Second & D Streets, Boron, Kern County, CA

Credit BG. Southeast and northeast facades of concrete block structure ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. Southeast and northeast facades of concrete block structure built in the late 1960s. It is now used to store miscellaneous equipment - Edwards Air Force Base, North Base, Liquid Oxygen Storage Facility, Second Street, Boron, Kern County, CA

Detail of north side of Test Stand 'A' base, showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of north side of Test Stand 'A' base, showing tanks for distilled water (left), fuel (center), and gaseous nitrogen (right). Other tanks present for tests were removed before this image was taken. - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

Credit PSR. View looks northeast (40°) across Imhoff Tank (Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit PSR. View looks northeast (40°) across Imhoff Tank (Building 4331) Imhoff Tank. This World War II wooden structure served as a sewage treatment facility for North Base - Edwards Air Force Base, North Base, Imhoff Tank, Southwest of E Street, Boron, Kern County, CA

6. AN EARLY VIEW OF THE COMPLETE X15 VEHICLE TEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. AN EARLY VIEW OF THE COMPLETE X-15 VEHICLE TEST STAND. Looking to the northeast. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

SOUTHWEST SIDE AND SOUTHEAST FRONT, BUILDING 1932. OBSERVATION WINDOWS ARE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHWEST SIDE AND SOUTHEAST FRONT, BUILDING 1932. OBSERVATION WINDOWS ARE BEHIND THE METAL GRATING. ENTRY HATCH IS ON NORTHWEST FACADE - Edwards Air Force Base, X-15 Engine Test Complex, Observation Bunker Types, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

VIEW OF TANK (BLDG. 1929) AND GARAGE (BLDG. 1930). SHOP ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF TANK (BLDG. 1929) AND GARAGE (BLDG. 1930). SHOP (BUILDING 1928) IS THE LARGER STRUCTURE IN THE BACKGROUND. Looking southeast - Edwards Air Force Base, X-15 Engine Test Complex, Tank & Garage, Rogers Dry Lake, east of Runway between North Base & South Base, Boron, Kern County, CA

Modeling of the minimum variable blank holder force based on forming limit diagram (FLD) in deep drawing process

NASA Astrophysics Data System (ADS)

Candra, S.; Batan, I. M. L.; Berata, W.; Pramono, A. S.

2017-11-01

This paper presents the mathematical approach of minimum blank holder force to prevent wrinkling in deep drawing process of the cylindrical cup. Based on the maximum of minor-major strain ratio, the slab method was applied to determine the modeling of minimum variable blank holder force (VBHF) and it compared to FE simulation. The Tin steel sheet of T4-CA grade, with the thickness of 0.2 mm was used in this study. The modeling of minimum VBHF can be used as a simple reference to prevent wrinkling in deep drawing.

Relationship between depolarization-induced force responses and Ca2+ content in skeletal muscle fibres of rat and toad.

PubMed

Owen, V J; Lamb, G D; Stephenson, D G; Fryer, M W

1997-02-01

1. The relationship between the total Ca2+ content of a muscle fibre and the magnitude of the force response to depolarization was examined in mechanically skinned fibres from the iliofibularis muscle of the toad and the extensor digitorum longus muscle of the rat. The response to depolarization in each skinned fibre was assessed either at the endogenous level of Ca2+ content or after depleting the fibre of Ca2+ to some degree. Ca2+ content was determined by a fibre lysing technique. 2. In both muscle types, the total Ca2+ content could be reduced from the endogenous level of approximately 1.3 mmol l-1 (expressed relative to intact fibre volume) to approximately 0.25 mmol l-1 by either depolarization or caffeine application in the presence of Ca2+ chelators, showing that the great majority of the Ca2+ was stored in the sarcoplasmic reticulum (SR). Chelation of Ca2+ in the transverse tubular (T-) system, either by exposure of fibres to EGTA before skinning or by permeabilizing the T-system with saponin after skinning, reduced the lower limit of Ca2+ content to < or = 0.12 mmol l-1, indicating that 10-20% of the total fibre Ca2+ resided in the T-system. 3. In toad fibres, both the peak and the area (i.e. time integral) of the force response to depolarization were reduced by any reduction in SR Ca2+ content, with both decreasing to zero in an approximately linear manner as the SR Ca2+ content was reduced to < 15% of the endogenous level. In rat fibres, the peak size of the force response was less affected by small decreases in SR content, but both the peak and area of the response decreased to zero with greater depletion. In partially depleted toad fibres, inhibition of SR Ca2+ uptake potentiated the force response to depolarization almost 2-fold. 4. The results show that in this skinned fibre preparation: (a) T-system depolarization and caffeine application can each virtually fully deplete the SR of Ca2+, irrespective of any putative inhibitory effect of SR depletion on channel activation; (b) all of the endogenous level of SR Ca2+ must be released in order to produce a maximal response to depolarization; and (c) a substantial part (approximately 40%) of the Ca2+ released by a depolarization is normally taken back into the SR before it can contribute to force production.

Relationship between depolarization-induced force responses and Ca2+ content in skeletal muscle fibres of rat and toad.

PubMed Central

Owen, V J; Lamb, G D; Stephenson, D G; Fryer, M W

1997-01-01

1. The relationship between the total Ca2+ content of a muscle fibre and the magnitude of the force response to depolarization was examined in mechanically skinned fibres from the iliofibularis muscle of the toad and the extensor digitorum longus muscle of the rat. The response to depolarization in each skinned fibre was assessed either at the endogenous level of Ca2+ content or after depleting the fibre of Ca2+ to some degree. Ca2+ content was determined by a fibre lysing technique. 2. In both muscle types, the total Ca2+ content could be reduced from the endogenous level of approximately 1.3 mmol l-1 (expressed relative to intact fibre volume) to approximately 0.25 mmol l-1 by either depolarization or caffeine application in the presence of Ca2+ chelators, showing that the great majority of the Ca2+ was stored in the sarcoplasmic reticulum (SR). Chelation of Ca2+ in the transverse tubular (T-) system, either by exposure of fibres to EGTA before skinning or by permeabilizing the T-system with saponin after skinning, reduced the lower limit of Ca2+ content to < or = 0.12 mmol l-1, indicating that 10-20% of the total fibre Ca2+ resided in the T-system. 3. In toad fibres, both the peak and the area (i.e. time integral) of the force response to depolarization were reduced by any reduction in SR Ca2+ content, with both decreasing to zero in an approximately linear manner as the SR Ca2+ content was reduced to < 15% of the endogenous level. In rat fibres, the peak size of the force response was less affected by small decreases in SR content, but both the peak and area of the response decreased to zero with greater depletion. In partially depleted toad fibres, inhibition of SR Ca2+ uptake potentiated the force response to depolarization almost 2-fold. 4. The results show that in this skinned fibre preparation: (a) T-system depolarization and caffeine application can each virtually fully deplete the SR of Ca2+, irrespective of any putative inhibitory effect of SR depletion on channel activation; (b) all of the endogenous level of SR Ca2+ must be released in order to produce a maximal response to depolarization; and (c) a substantial part (approximately 40%) of the Ca2+ released by a depolarization is normally taken back into the SR before it can contribute to force production. PMID:9051571

Role of extracellular and intracellular sources of Ca2+ in sarafotoxin S6b-induced contraction of strips of the rat aorta.

PubMed Central

Watanabe, C.; Hirano, K.; Kanaide, H.

1993-01-01

1. The effect of sarafotoxin S6b (sarafotoxin), a vasoconstrictor peptide, on cytosolic Ca2+ concentration ([Ca2+]i) and force in rat aortic strips loaded with fura-2 was determined by front-surface fluorometry. The objective was to elucidate the role of extracellular and intracellular Ca2+ in the mechanism of action of this peptide. 2. In the presence of extracellular 1.25 mM Ca2+, sarafotoxin induced a biphasic response consisting of an initial rapid increase in [Ca2+]i followed by a secondary sustained increase. Tension developed slowly but was sustained during the application of sarafotoxin. Diltiazem (10 nM-0.1 mM) partially inhibited both the increases in [Ca2+]i and tension. 3. In the presence of extracellular Ca2+, the force developed in relation to the increase in [Ca2+]i ([Ca2+]i-force relationship) observed with sarafotoxin was much greater than that observed upon K+ depolarization. In the presence of diltiazem the sarafotoxin-induced [Ca2+]i-force relationship was shifted even further to the left. 4. In the absence of extracellular Ca2+, sarafotoxin induced a transient increase in [Ca2+]i and a sustained contraction. Extending the incubation time in Ca(2+)-free physiological solution, resulted in smaller responses. However, after 60 min in Ca(2+)-free solution, sarafotoxin induced a sustained contraction but no change in [Ca2+]i. This residual contraction was inhibited by H-7, which is known to inhibit protein kinase C. 5. After treatment with caffeine to reduce intracellular stored Ca2+, sarafotoxin could still elicit increases in [Ca2+]i and in tension, showing that the caffeine-sensitive intracellular Ca2+ store partially overlaps with the sarafotoxin-sensitive store.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8428211

4. AERIAL VIEW FROM THE SOUTH OF (LEFT TO RIGHT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. AERIAL VIEW FROM THE SOUTH OF (LEFT TO RIGHT CENTER) LOB (BLDG. 763), TECHNICAL SUPPORT BUILDING (BLDG. 762/762A), AND SLC-3 AIR FORCE BUILDING (BLDG. 761). SOUTH SIDE OF SLC-3 WEST IN LEFT BACKGROUND. OCEAN IN DISTANT BACKGROUND. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

4. "ARCHITECTURAL, FLOOR PLANELEVATIONSSECTIONS, OBSERVATION BUNKERS." Specifications No. ENG (NASA)04353631; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. "ARCHITECTURAL, FLOOR PLAN-ELEVATIONS-SECTIONS, OBSERVATION BUNKERS." Specifications No. ENG (NASA)04-353-63-1; Drawing No. 60-09-34; sheet 325. Ref. No. A-13. D.O. SERIES 1597/87. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunker 1-D-3, Test Area 1-125, northwest end of Altair Boulevard, Boron, Kern County, CA

Determination of Thermodynamic Properties of Alkaline Earth-liquid Metal Alloys Using the Electromotive Force Technique

PubMed Central

Nigl, Thomas P.; Smith, Nathan D.; Lichtenstein, Timothy; Gesualdi, Jarrod; Kumar, Kuldeep; Kim, Hojong

2017-01-01

A novel electrochemical cell based on a CaF2 solid-state electrolyte has been developed to measure the electromotive force (emf) of binary alkaline earth-liquid metal alloys as functions of both composition and temperature in order to acquire thermodynamic data. The cell consists of a chemically stable solid-state CaF2-AF2 electrolyte (where A is the alkaline-earth element such as Ca, Sr, or Ba), with binary A-B alloy (where B is the liquid metal such as Bi or Sb) working electrodes, and a pure A metal reference electrode. Emf data are collected over a temperature range of 723 K to 1,123 K in 25 K increments for multiple alloy compositions per experiment and the results are analyzed to yield activity values, phase transition temperatures, and partial molar entropies/enthalpies for each composition. PMID:29155770

Contextual view including south (rear) of building 925, exercise in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Contextual view including south (rear) of building 925, exercise in foreground, and modern buildings in background. Facing northwest. - Travis Air Force Base, Building No. 925, W Street, Fairfield, Solano County, CA

2. INTERIOR VIEW OF ENTRY CONTROL POINT (BLDG. 768) FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. INTERIOR VIEW OF ENTRY CONTROL POINT (BLDG. 768) FROM SOUTHWEST CORNER - Vandenberg Air Force Base, Space Launch Complex 3, Entry Control Point, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Telephone equipment room, showing channel terminal bank with vacuum tubes. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Telephone equipment room, showing channel terminal bank with vacuum tubes. View to east - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

32. DETAIL OF PRESSURE GAUGE INSTALLED ON BUNKER PERISCOPE IN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

32. DETAIL OF PRESSURE GAUGE INSTALLED ON BUNKER PERISCOPE IN 1991 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

2. WEST REAR, WITH PORTHOLE ESCAPE HATCH ABOVE ENTRY DOOR. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. WEST REAR, WITH PORTHOLE ESCAPE HATCH ABOVE ENTRY DOOR. - Edwards Air Force Base, South Base Sled Track, Firing & Control Blockhouse for 10,000-foot Track, South of Sled Track at midpoint of 20,000-foot track, Lancaster, Los Angeles County, CA

12. DETAIL, ENTRY STAIRWELL TO CABLE TUNNEL, LAUNCHING PAD IN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. DETAIL, ENTRY STAIRWELL TO CABLE TUNNEL, LAUNCHING PAD IN THE LEFT DISTANCE, TRACKSIDE CAMERA STAND AT TOP CENTER. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

7. BULLET GLASS OBSERVATION WINDOW AT GROUND LEVEL ON WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. BULLET GLASS OBSERVATION WINDOW AT GROUND LEVEL ON WEST REAR. - Edwards Air Force Base, South Base Sled Track, Firing & Control Blockhouse for 10,000-foot Track, South of Sled Track at midpoint of 20,000-foot track, Lancaster, Los Angeles County, CA

10. Credit USAF, 1945. Original housed in the Muroc Flight ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Credit USAF, 1945. Original housed in the Muroc Flight Test Base, Unit History, 1 September 1942 30 June 1945. Alfred F. Simpson Historical Research Agency. United States Air Force. Maxwell AFB, Alabama. View of jet engine rotor balancing machine with engine rotor in place for balancing operations. Original caption reads "Balancing bucket wheel of jet engine, Muroc Flight Test Base, Oct. 1945"; personnel not identified. Location where photograph was taken not determined, but presumed to be in shops of Building 4505. - Edwards Air Force Base, North Base, Hangar, End of North Base Road, Boron, Kern County, CA

Credit PSR. View looks south (180°) across North Base Road ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit PSR. View looks south (180°) across North Base Road at foundations for Quarters "A", one arm of which appears at right. Bare earth at extreme left is entrance to parking lot between Quarters "A" and "B" - Edwards Air Force Base, North Base, Officers' Quarters B, North Base Road, Boron, Kern County, CA

USMC’s Environmental Management Portal for EMS Implementation Service-wide Rollout and Future Plans

DTIC Science & Technology

2010-06-16

Si:e m Edit Page EM flortal HOMC Fnwnnm1~nt. Welcome to the E~l : xecJtive Order (:O) 13148, m~lemented at all aplicable Le9dership h Ewironmnt91...Buttalion Reserve Marine lntelliQence Support Mobile Forces Buttalion Reserve Marine Intelligence Support San Diego Forces Buttalion Reserve...washington, De CA LonQ Beach, Ca FL West Palm Beach, Fl LA New Orleans, La LA New Orleans, La AL Mobile , AI CA San Diego, Ca CA San Diego

Effects of manipulating tetanic calcium on the curvature of the force-velocity relationship in isolated rat soleus muscles.

PubMed

Kristensen, A M; Nielsen, O B; Overgaard, K

2018-03-01

In dynamically contracting muscles, increased curvature of the force-velocity relationship contributes to the loss of power during fatigue. It has been proposed that fatigue-induced reduction in [Ca ++ ] i causes this increased curvature. However, earlier studies on single fibres have been conducted at low temperatures. Here, we investigated the hypothesis that curvature is increased by reductions in tetanic [Ca ++ ] i in isolated skeletal muscle at near-physiological temperatures. Rat soleus muscles were stimulated at 60 Hz in standard Krebs-Ringer buffer, and contraction force and velocity were measured. Tetanic [Ca ++ ] i was in some experiments either lowered by addition of 10 μmol/L dantrolene or use of submaximal stimulation (30 Hz) or increased by addition of 2 mmol/L caffeine. Force-velocity curves were constructed by fitting shortening velocity at different loading forces to the Hill equation. Curvature was determined as the ratio a/F 0 with increased curvature reflecting decreased a/F 0 . Compared to control levels, lowering tetanic [Ca ++ ] i with dantrolene or reduced stimulation frequency decreased the curvature slightly as judged from increase in a/F 0 of 13 ± 1% (P = < .001) and 20 ± 2% (P = < .001) respectively. In contrast, increasing tetanic [Ca ++ ] i with caffeine increased the curvature (a/F 0 decreased by 17 ± 1%; P = < .001). Contrary to our hypothesis, interventions that reduced tetanic [Ca ++ ] i caused a decrease in curvature, while increasing tetanic [Ca ++ ] i increased the curvature. These results reject a simple causal relation between [Ca ++ ] i and curvature of the force-velocity relation during fatigue. © 2017 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

6. Credit GE. Photographic copy of photograph, view looking east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Credit GE. Photographic copy of photograph, view looking east at Test Stand 'A' during test firing of a liquid-fueled Corporal engine. Structure in immediate left foreground of view appears to be a propellant tank enclosure (JPL negative no. 383-1225, July 1945); compare HAER CA-163-A-7 for enclosure. - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

Toward an Integrative Computational Model of the Guinea Pig Cardiac Myocyte

PubMed Central

Gauthier, Laura Doyle; Greenstein, Joseph L.; Winslow, Raimond L.

2012-01-01

The local control theory of excitation-contraction (EC) coupling asserts that regulation of calcium (Ca2+) release occurs at the nanodomain level, where openings of single L-type Ca2+ channels (LCCs) trigger openings of small clusters of ryanodine receptors (RyRs) co-localized within the dyad. A consequence of local control is that the whole-cell Ca2+ transient is a smooth continuous function of influx of Ca2+ through LCCs. While this so-called graded release property has been known for some time, its functional importance to the integrated behavior of the cardiac ventricular myocyte has not been fully appreciated. We previously formulated a biophysically based model, in which LCCs and RyRs interact via a coarse-grained representation of the dyadic space. The model captures key features of local control using a low-dimensional system of ordinary differential equations. Voltage-dependent gain and graded Ca2+ release are emergent properties of this model by virtue of the fact that model formulation is closely based on the sub-cellular basis of local control. In this current work, we have incorporated this graded release model into a prior model of guinea pig ventricular myocyte electrophysiology, metabolism, and isometric force production. The resulting integrative model predicts the experimentally observed causal relationship between action potential (AP) shape and timing of Ca2+ and force transients, a relationship that is not explained by models lacking the graded release property. Model results suggest that even relatively subtle changes in AP morphology that may result, for example, from remodeling of membrane transporter expression in disease or spatial variation in cell properties, may have major impact on the temporal waveform of Ca2+ transients, thus influencing tissue level electromechanical function. PMID:22783206

Toward an integrative computational model of the Guinea pig cardiac myocyte.

PubMed

Gauthier, Laura Doyle; Greenstein, Joseph L; Winslow, Raimond L

2012-01-01

The local control theory of excitation-contraction (EC) coupling asserts that regulation of calcium (Ca(2+)) release occurs at the nanodomain level, where openings of single L-type Ca(2+) channels (LCCs) trigger openings of small clusters of ryanodine receptors (RyRs) co-localized within the dyad. A consequence of local control is that the whole-cell Ca(2+) transient is a smooth continuous function of influx of Ca(2+) through LCCs. While this so-called graded release property has been known for some time, its functional importance to the integrated behavior of the cardiac ventricular myocyte has not been fully appreciated. We previously formulated a biophysically based model, in which LCCs and RyRs interact via a coarse-grained representation of the dyadic space. The model captures key features of local control using a low-dimensional system of ordinary differential equations. Voltage-dependent gain and graded Ca(2+) release are emergent properties of this model by virtue of the fact that model formulation is closely based on the sub-cellular basis of local control. In this current work, we have incorporated this graded release model into a prior model of guinea pig ventricular myocyte electrophysiology, metabolism, and isometric force production. The resulting integrative model predicts the experimentally observed causal relationship between action potential (AP) shape and timing of Ca(2+) and force transients, a relationship that is not explained by models lacking the graded release property. Model results suggest that even relatively subtle changes in AP morphology that may result, for example, from remodeling of membrane transporter expression in disease or spatial variation in cell properties, may have major impact on the temporal waveform of Ca(2+) transients, thus influencing tissue level electromechanical function.

Effect of Ca2+ ion concentration on adsorption of poly(carboxylate ether)-based (PCE) superplasticizer on mica.

PubMed

Wu, Bo; Chun, Byong-Wa; Gu, Le; Kuhl, Tonya L

2018-05-09

Poly(carboxylate ether)-based (PCE) superplasticizers consist of a carboxylic acid backbone and grafted poly(ethylene glycol) (PEG) side chains. Ca 2+ ion bridging mechanism is commonly purported to control PCE's adsorption on negatively charged cement particle surfaces in cement suspension, thus PCE was expected to adsorb on negatively charged surfaces in synthetic pore solutions via Ca 2+ /COO - interactions. Adsorption behaviors of a commercial PCE on negatively charged mica were studied in aqueous electrolyte solutions by a surface forces apparatus. Direct force measurements indicated that the PCE adsorbed onto mica from 0.1 M K 2 SO 4 due to K + ion chelation by the ether oxygen units CH 2 CH 2 O on the PEG chains, but surprisingly did not adsorb from either 0.1 M K 2 SO 4 with saturated Ca(OH) 2 or 0.1 M Ca(NO 3 ) 2 . The adsorption in K 2 SO 4 was weak, enabling the adsorbed PCE layers to be squeezed out under modest compression. Upon separating the surfaces, the PCE immediately achieved an identical re-adsorption. In high-calcium conditions, the PCE was highly positively charged due to Ca 2+ ion chelation by PEG chains and backbone carboxylic groups COO - , and mica also underwent charge reversal due to electrostatic adsorption/binding of Ca 2+ ions. Consequently, the interaction between mica and PCE was electrostatically repulsive and no PCE adsorption occurred. These findings can be explained by the complex interplay of ion chelation by PEG chains, electrostatic binding and screening interactions with charged surfaces in the presence of monovalent and divalent counterions, and ultimately charge reversal of both the charged surfaces and polyelectrolyte in high divalent ion conditions. Copyright © 2018 Elsevier Inc. All rights reserved.

The Soviet Air Force and Strategic Bombing

DTIC Science & Technology

1999-04-01

to envision a British Air Force that could be totally divorced from some form of ground support role. Consequently, he saw an air campaign that would...CA: Presidio Press, 1986. Black, Steven K. The Icarus Illusion: Technology, Doctrine and the Soviet Air Force. Monterrey , CA, 1986. Cockburn, Andrew

Elevations. March Air Force Base, Riverside, California, Combat Operations Center, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Elevations. March Air Force Base, Riverside, California, Combat Operations Center, Combat Operations Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 14, approved March, 1962; specifications no. ENG-04-353-62-66; D.O. series AW 1596/14, Rev. "B"; file drawer 77-1/102. Last revised 3 October 1966. Scale one-eighth inch to one foot. 30x36 inches. photocopy on paper - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

Blebbistatin, a myosin II inhibitor, suppresses Ca(2+)-induced and "sensitized"-contraction of skinned tracheal muscles from guinea pig.

PubMed

Yumoto, Masatoshi; Watanabe, Masaru

2013-01-01

Blebbistatin, a potent inhibitor of myosin II, has inhibiting effects on Ca(2+)-induced contraction and contractile filament organization without affecting the Ca(2+)-sensitivity to the force and phosphorylation level of myosin regulatory light chain (MLC20) in skinned (cell membrane permeabilized) taenia cecum from the guinea pig (Watanabe et al., Am J Physiol Cell Physiol. 2010; 298: C1118-26). In the present study, we investigated blebbistatin effects on the contractile force of skinned tracheal muscle, in which myosin filaments organization is more labile than that in the taenia cecum. Blebbistatin at 10 μM or higher suppressed Ca(2+)-induced tension development at any given Ca(2+) concentration, but had little effects on the Ca(2+)- induced myosin light chain phosphorylation. Also blebbistatin at 10 μM and higher significantly suppressed GTP-γS-induced "sensitized" force development. Since the force inhibiting effects of blebbistatin on the skinned trachea were much stronger than those in skinned taenia cecum, blebbistatin might directly affect myosin filaments organization.

Urban Growth Modeling Using Cellular Automata with Multi-Temporal Remote Sensing Images Calibrated by the Artificial Bee Colony Optimization Algorithm.

PubMed

Naghibi, Fereydoun; Delavar, Mahmoud Reza; Pijanowski, Bryan

2016-12-14

Cellular Automata (CA) is one of the most common techniques used to simulate the urbanization process. CA-based urban models use transition rules to deliver spatial patterns of urban growth and urban dynamics over time. Determining the optimum transition rules of the CA is a critical step because of the heterogeneity and nonlinearities existing among urban growth driving forces. Recently, new CA models integrated with optimization methods based on swarm intelligence algorithms were proposed to overcome this drawback. The Artificial Bee Colony (ABC) algorithm is an advanced meta-heuristic swarm intelligence-based algorithm. Here, we propose a novel CA-based urban change model that uses the ABC algorithm to extract optimum transition rules. We applied the proposed ABC-CA model to simulate future urban growth in Urmia (Iran) with multi-temporal Landsat images from 1997, 2006 and 2015. Validation of the simulation results was made through statistical methods such as overall accuracy, the figure of merit and total operating characteristics (TOC). Additionally, we calibrated the CA model by ant colony optimization (ACO) to assess the performance of our proposed model versus similar swarm intelligence algorithm methods. We showed that the overall accuracy and the figure of merit of the ABC-CA model are 90.1% and 51.7%, which are 2.9% and 8.8% higher than those of the ACO-CA model, respectively. Moreover, the allocation disagreement of the simulation results for the ABC-CA model is 9.9%, which is 2.9% less than that of the ACO-CA model. Finally, the ABC-CA model also outperforms the ACO-CA model with fewer quantity and allocation errors and slightly more hits.

Urban Growth Modeling Using Cellular Automata with Multi-Temporal Remote Sensing Images Calibrated by the Artificial Bee Colony Optimization Algorithm

PubMed Central

Naghibi, Fereydoun; Delavar, Mahmoud Reza; Pijanowski, Bryan

2016-01-01

Cellular Automata (CA) is one of the most common techniques used to simulate the urbanization process. CA-based urban models use transition rules to deliver spatial patterns of urban growth and urban dynamics over time. Determining the optimum transition rules of the CA is a critical step because of the heterogeneity and nonlinearities existing among urban growth driving forces. Recently, new CA models integrated with optimization methods based on swarm intelligence algorithms were proposed to overcome this drawback. The Artificial Bee Colony (ABC) algorithm is an advanced meta-heuristic swarm intelligence-based algorithm. Here, we propose a novel CA-based urban change model that uses the ABC algorithm to extract optimum transition rules. We applied the proposed ABC-CA model to simulate future urban growth in Urmia (Iran) with multi-temporal Landsat images from 1997, 2006 and 2015. Validation of the simulation results was made through statistical methods such as overall accuracy, the figure of merit and total operating characteristics (TOC). Additionally, we calibrated the CA model by ant colony optimization (ACO) to assess the performance of our proposed model versus similar swarm intelligence algorithm methods. We showed that the overall accuracy and the figure of merit of the ABC-CA model are 90.1% and 51.7%, which are 2.9% and 8.8% higher than those of the ACO-CA model, respectively. Moreover, the allocation disagreement of the simulation results for the ABC-CA model is 9.9%, which is 2.9% less than that of the ACO-CA model. Finally, the ABC-CA model also outperforms the ACO-CA model with fewer quantity and allocation errors and slightly more hits. PMID:27983633

Slow Decomposition of Silicone Rubber.

DTIC Science & Technology

1982-09-01

6i 0 20 0 0 -c CA soa ,~ I -- 00 N - C,,l I 21. DYN 6181 DISTRIBUTION LIST No. Cooies No. Cooies Dr. L.V. Schmidt 1 Or. F. Roberto 1 Assistant...Scientific Dr. A.L. Slafkosky 1 Research Scientific Advisor Directorate of Aerosoace Sciences Commandant of the Marine Corps Bolling Air Force Base Code...Research Research Code 413 Directorate of Chemical Sciences Arlington, VA 22217 Bolling Air Force Base Washington, D.C. 20332 M r . Da v id S i e g e lD r J

Los Angeles, CA.

NASA Image and Video Library

1992-03-30

STS003-010-593 (30 March 1982) --- A general view of the greater Los Angeles region of California (34,0N, 118.5W) showing the coastline, Vandenberg AFB, the south end of the Central Valley and the dry lake beds at Edwards AFB. A close look can pinpoint water on the lake beds at Edwards Air Force Base used previously for two shuttle landings. Among other features that can be seen are Oxnard, Santa Barbara, Bakersfield, Vandenberg Air Force Base, and The Ranch. Photo credit: NASA

11. "NIGHT SCENE OF TEST AREA WITH TEST STAND 1A ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. "NIGHT SCENE OF TEST AREA WITH TEST STAND 1-A IN FOREGROUND. LIGHTS OF MAIN BASE, EDWARDS AFB, IN THE BACKGROUND. EDWARDS AFB." Test Area 1-120. Looking west past Test Stand 1-A to Test Area 1-115 and Test Area 1-110. Photo no. "12,401 57; G-AFFTC 12 DEC 57; TS 1-A Aux #1". - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

Environmental Assessment Anti-Terrorism/Force Protection Travis Air Force Base, California

DTIC Science & Technology

2003-09-01

Forbes Street and De Ronde Drive 0630 to 0900 and 1145 to 1630 weekdays POV, school buses, school children and their parents 225 POV privately...03L North Gate- Vacaville Gate Air Base Pkwy. Ra gsi de St. Hangar Ave. Travis Ave. Bu rg an B lvd . Hickam Ave. Fi rs t S t. Broadway St. Ca nn on D...Facility Addition and Alteration to Life Support Shop Taxiway Lima Repairs Electrical, Utilities, and Supporting Infrastructure* Engine Storage Facility

1. STATION "50" AREA OVERVIEW, BUILDING 0512 AT FAR LEFT, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. STATION "50" AREA OVERVIEW, BUILDING 0512 AT FAR LEFT, AND PADS FOR SHOP AND STORAGE BUILDINGS IN CENTER. Looking northeast. - Edwards Air Force Base, South Base Sled Track, Instrumentation & Control Building, South of Sled Track, Station "50" area, Lancaster, Los Angeles County, CA

Environmental Impact Analysis Process, Environmental Assessment Space Test Experiments Platform Mission 1, Vandenberg Air Force Base, CA

DTIC Science & Technology

1994-01-05

Information LOCAL AGENCIES Santa Barbara County Air Pollution Control District, California Hallerman , Richard Air Quality Specialist City of...Base. Provided by Richard Hallerman , SBCAPCD, to Bob Baxter, Engineering-Science. 11 June. ____, 1991. Santa Barbara County Air Pollution Control

7. Credit PSR. Interior of Building 4401, looking 200° (south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Credit PSR. Interior of Building 4401, looking 200° (south southwest), showing original interior wooden construction of walls and roof trusses. Hangar is presently used for storage. - Edwards Air Force Base, North Base, Hangar No. 1, First & B Streets, Boron, Kern County, CA

41. VIEW OF UMBILICAL MAST AND LAUNCH PAD FROM LAUNCHER; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. VIEW OF UMBILICAL MAST AND LAUNCH PAD FROM LAUNCHER; SOUTH FACE OF MST IN BACKGROUND. RAIL SYSTEM FROM BASE OF MST PARALLEL TO MAST. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Credit BG. View looks north northwest (325°) towards Administration Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. View looks north northwest (325°) towards Administration Building across aircraft apron east of Building 4505. Building 4507 (Storage Building) appears at extreme right of view - Edwards Air Force Base, North Base, Administration Building, Northeast of A Street, Boron, Kern County, CA

1. ROCKET ENGINE TEST STAND, LOCATED IN THE NORTHEAST ¼ ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. ROCKET ENGINE TEST STAND, LOCATED IN THE NORTHEAST ¼ OF THE X-15 ENGINE TEST COMPLEX. Looking northeast. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

3. COMPLETE X15 VEHICLE TEST STAND, LOCATED IN SOUTHEAST ¼ ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. COMPLETE X-15 VEHICLE TEST STAND, LOCATED IN SOUTHEAST ¼ OF X-15 ENGINE TEST COMPLEX. Looking northeast. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

4. COMPLETE X15 VEHICLE TEST STAND, DETAIL OF THRUST MOUNTING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. COMPLETE X-15 VEHICLE TEST STAND, DETAIL OF THRUST MOUNTING STRUCTURE AT ENGINE END OF PLANE. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

4. "X15 TYPICAL MISSION." A photo of a map graphic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. "X-15 TYPICAL MISSION." A photo of a map graphic showing a flight path from Wendover to Edwards, with an inset graphic showing the landing pattern turns. - Edwards Air Force Base, X-15 Engine Test Complex, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

2. ROCKET ENGINE TEST STAND, SHOWING TANK (BUILDING 1929) AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. ROCKET ENGINE TEST STAND, SHOWING TANK (BUILDING 1929) AND GARAGE (BUILDING 1930) AT LEFT REAR. Looking to west. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

104. VIEW OF CABLE RACEWAY BENEATH REMOVABLE FLOOR PANEL IN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

104. VIEW OF CABLE RACEWAY BENEATH REMOVABLE FLOOR PANEL IN LANDLINE INSTRUMENTATION ROOM - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

91. VIEW OF OXYGEN AND GASEOUS NITROGEN TANKS AND OXIDIZER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

91. VIEW OF OXYGEN AND GASEOUS NITROGEN TANKS AND OXIDIZER APRON FROM NORTH - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

48. DETAIL OF REAR OF DEMULTIPLEX PANEL 5 SHOWING COMPONENTS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. DETAIL OF REAR OF DEMULTIPLEX PANEL 5 SHOWING COMPONENTS OF VACUUM-TUBE OSCILLOSCOPE - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

125. TRANSFORMER SUBSTATIONS ON NORTH SIDE OF TRANSFORMER ROOM (112), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

125. TRANSFORMER SUBSTATIONS ON NORTH SIDE OF TRANSFORMER ROOM (112), FACING SOUTH - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

92. VIEW OF CHART RECORDERS AND PERSONAL COMPUTER LINING NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

92. VIEW OF CHART RECORDERS AND PERSONAL COMPUTER LINING NORTHEAST CORNER OF AUTOPILOT ROOM - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

15. HISTORIC PHOTOGRAPH. ENGINE TEST CELL BUILDING FRONT FACADE DATED ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. HISTORIC PHOTOGRAPH. ENGINE TEST CELL BUILDING FRONT FACADE DATED CA. 1975. LOOKING NORTH. - Fairchild Air Force Base, Engine Test Cell Building, Near intersection of Arnold Street & George Avenue, Spokane, Spokane County, WA

Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Introduction, Background and Conclusions (Chapters 1-5, 18, 19)

DTIC Science & Technology

1991-03-01

SAIC Editors: Cynthia A. Marut Ellsabeth M. Smoda SCIENCE APPLICATIONS EPIDEMIOLOGY RESEARCH DIVISION INTERNATIONAL CORPORATION ARMSTRONG LABORATORY...8400 Westpark Drive HUMAN SYSTEMS DIVISION (AFSC) McLean, VA 22102 Brooks Air Force Base, TX 78235 in con/unction WithS~DTIC SCRIPPS CLINIC & RESEARCH ...FOUNDATION, LET LA JOLLA. CA ELECTEJ•UL 011991, NATIONAL OPINION RESEARCH CENTER. CHICAGO. IL Marchl 1tO1 Introduction. Backgroend and Conclusions

1. Credit USAF, ca. 1945. Original housed in the Records ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Credit USAF, ca. 1945. Original housed in the Records of the Defense Intelligence Agency. Record Group 373. National Archives. Cartographic and Architectural Branch. Washington, D.C. Oblique aerial photo 16PS5M79-1-0-46-4:3:1146-12:120003500N11745W looks northeast across North Base, then known as Muroc Flight Test Base. Rogers Dry lake is in view to the right, bordered by four hangars; 6,000 foot runway built in 1943 is in background. Fenced area in immediate foreground (not extant in 1995) was a "Chemical Storage Area" also designated a fuel storage facility on some engineering drawings; two small ponds nearby were for sewage sludge. Black square in middle of view is recently oiled or paved parking lot surrounding Building 4340 (T-73), the Recreation Hall/Chapel (not extant in 1995). - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

Altered myocardial force generation in end-stage human heart failure.

PubMed

Papp, Zoltán; van der Velden, Jolanda; Borbély, Attila; Édes, István; Stienen, Ger J M

2014-12-01

This study aimed to elucidate the molecular background of increased Ca 2+ sensitivity of force production in cardiomyocytes of end-stage human heart failure. Ca 2+ -activated isometric force and the cross-bridge specific rate of force redevelopment (k tr ) were determined in Triton-skinned myocytes from end-stage failing and non-failing donor hearts. Measurements (control: pH 7.2, 0 mM inorganic phosphate (P i )) were performed under test conditions that probed either the Ca 2+ -regulatory function of the thin filaments (pH 6.5), the kinetics of the actin-myosin cross-bridge cycle (10 mM P i ), or both (pH 6.5, 10 mM P i ). The control maximal Ca 2+ -activated force (F o ) and k trmax did not differ between failing and non-failing myocytes. At submaximal [Ca 2+ ], however, both force and k tr were higher in failing than in donor myocytes. The difference in the Ca 2+ sensitivities of force production was preserved when the thin filament regulatory function was perturbed by acidosis (pH 6.5) but was abolished by cross-bridge modulation (i.e. by P i ) both at pH 7.2 and at pH 6.5. P i induced a larger reduction in force but a smaller increase in k tr in the failing myocytes than in the non-failing myocytes at submaximal [Ca 2+ ]. The enhanced P i sensitivity of the actin-myosin interaction suggests that the P i release step of the actin-myosin cross-bridge cycle is modified during end-stage human heart failure. This might be of functional importance when P i accumulates (e.g. during cardiac ischaemia). Moreover, this alteration can influence cardiac energetics and the clinical efficacy of sarcomere targeted agents in human heart failure. © 2015 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

Juxtaposition of the changes in intracellular calcium and force during staircase potentiation at 30 and 37°C

PubMed Central

Vandenboom, Rene

2014-01-01

Ca2+ entry during the action potential stimulates muscle contraction. During repetitive low frequency stimulation, skeletal muscle undergoes staircase potentiation (SP), a progressive increase in the peak twitch force induced by each successive stimulus. Multiple mechanisms, including myosin regulatory light chain phosphorylation, likely contribute to SP, a temperature-dependent process. Here, we used the Ca2+-sensitive fluorescence indicators acetoxymethyl (AM)-furaptra and AM-fura-2 to examine the intracellular Ca2+ transient (ICT) and the baseline Ca2+ level at the onset of each ICT during SP at 30 and 37°C in mouse lumbrical muscle. The stimulation protocol, 8 Hz for 8 s, resulted in a 27 ± 3% increase in twitch force at 37°C and a 7 ± 2% decrease in twitch force at 30°C (P < 0.05). Regardless of temperature, the peak rate of force production (+df/dt) was higher in all twitches relative to the first twitch (P < 0.05). Consistent with the differential effects of stimulation on twitch force at the two temperatures, raw ICT amplitude decreased during repetitive stimulation at 30°C (P < 0.05) but not at 37°C. Cytosolic Ca2+ accumulated during SP such that baseline Ca2+ at the onset of ICTs occurring late in the train was higher (P < 0.05) than that of those occurring early in the train. ICT duration increased progressively at both temperatures. This effect was not entirely proportional to the changes in twitch duration, as twitch duration characteristically decreased before increasing late in the protocol. This is the first study identifying a changing ICT as an important, and temperature-sensitive, modulator of muscle force during repetitive stimulation. Moreover, we extend previous observations by demonstrating that contraction-induced increases in baseline Ca2+ coincide with greater +df/dt but not necessarily with higher twitch force. PMID:25422504

Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colson, Brett A.; Locher, Matthew R.; Bekyarova, Tanya

2010-05-25

Phosphorylation of myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK) and myosin binding protein-C (cMyBP-C) by protein kinase A (PKA) independently accelerate the kinetics of force development in ventricular myocardium. However, while MLCK treatment has been shown to increase the Ca{sup 2+} sensitivity of force (pCa{sub 50}), PKA treatment has been shown to decrease pCa{sub 50}, presumably due to cardiac troponin I phosphorylation. Further, MLCK treatment increases Ca{sup 2+}-independent force and maximum Ca{sup 2+}-activated force, whereas PKA treatment has no effect on either force. To investigate the structural basis underlying the kinase-specific differential effects on steady-state force,more » we used synchrotron low-angle X-ray diffraction to compare equatorial intensity ratios (I{sub 1,1}/I{sub 1,0}) to assess the proximity of myosin cross-bridge mass relative to actin and to compare lattice spacings (d{sub 1,0}) to assess the inter-thick filament spacing in skinned myocardium following treatment with either MLCK or PKA. As we showed previously, PKA phosphorylation of cMyBP-C increases I{sub 1,1}/I{sub 1,0} and, as hypothesized, treatment with MLCK also increased I{sub 1,1}/I{sub 1,0}, which can explain the accelerated rates of force development during activation. Importantly, interfilament spacing was reduced by {approx}2 nm ({Delta} 3.5%) with MLCK treatment, but did not change with PKA treatment. Thus, RLC or cMyBP-C phosphorylation increases the proximity of cross-bridges to actin, but only RLC phosphorylation affects lattice spacing, which suggests that RLC and cMyBP-C modulate the kinetics of force development by similar structural mechanisms; however, the effect of RLC phosphorylation to increase the Ca{sup 2+} sensitivity of force is mediated by a distinct mechanism, most probably involving changes in interfilament spacing.« less

Muscle length-dependent contribution of motoneuron Cav1.3 channels to force production in model slow motor unit.

PubMed

Kim, Hojeong

2017-07-01

Persistent inward current (PIC)-generating Ca v 1.3 channels in spinal motoneuron dendrites are thought to be actively recruited during normal behaviors. However, whether and how the activation of PIC channels influences force output of motor unit remains elusive. Here, building a physiologically realistic model of slow motor unit I demonstrated that force production induced by the PIC activation is much smaller for short than lengthened muscles during the regular firing of the motoneuron that transitions from the quiescent state by either a brief current pulse at the soma or a brief synaptic excitation at the dendrites. By contrast, the PIC-induced force potentiation was maximal for short muscles when the motoneuron switched from a stable low-frequency firing state to a stable high-frequency firing state by the current pulse at the soma. Under the synaptic excitation at the dendrites, however, the force could not be potentiated by the transitioning of the motoneuron from a low- to a high-frequency firing state due to the simultaneous onset of PIC at the dendrites and firing at the soma. The strong dependency of the input-output relationship of the motor unit on the neuromodulation and Ia afferent inputs for the PIC channels was further shown under static variations in muscle length. Taken together, these findings suggest that the PIC activation in the motoneuron dendrites may differentially affect the force production of the motor unit, depending not only on the firing state history of the motoneuron and the variation in muscle length but also on the mode of motor activity. NEW & NOTEWORTHY Ca v 1.3 channels in motoneuron dendrites are actively involved during normal motor activities. To investigate the effects of the activation of motoneuron Ca v 1.3 channels on force production, a model motor unit was built based on best-available data. The simulation results suggest that force potentiation induced by Ca v 1.3 channel activation is strongly modulated not only by firing history of the motoneuron but also by length variation of the muscle as well as neuromodulation inputs from the brainstem. Copyright © 2017 the American Physiological Society.

Credit BG. View looks south southwest (202°) across remains of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. View looks south southwest (202°) across remains of concrete pad foundation for the mess hall. North Base Road (3rd Street) passes nearby. Building 4318 is in the distance at the extreme left of view - Edwards Air Force Base, North Base, Base Mess Hall T-27, Third Street, Boron, Kern County, CA

3. AERIAL VIEW FROM THE EAST OF (FOREGROUND TO BACKGROUND) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. AERIAL VIEW FROM THE EAST OF (FOREGROUND TO BACKGROUND) SLC-3 AIR FORCE BUILDING (BLDG. 761), TECHNICAL SUPPORT BUILDING (BLDG. 762/762A), ENTRY CONTROL POINT (BLDG. 768), AND LOB (BLDG. 763). EAST SIDE OF SLC-3E MOBILE SERVICE TOWER (MST) VISIBLE IN UPPER LEFT CORNER. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

15. "GENERAL, INSTRUMENTATION AND CONTROL SYSTEMS, ISOMETRIC." Test Area 1120. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. "GENERAL, INSTRUMENTATION AND CONTROL SYSTEMS, ISOMETRIC." Test Area 1-120. Specifications No. ENG04-353-55-72; Drawing No. 60-09-12; sheet 6 of 148; file no. 1320/57. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

Instrumentation and control building, architectural, sections and elevation. Specifications No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Instrumentation and control building, architectural, sections and elevation. Specifications No. Eng -04-353-55-72; Drawing No. 60-09-12; sheet 65 of 148; file no. 1321/16. Stamped: record drawing - as constructed. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

13. "CIVIL, SITE PLAN AND VICINITY MAP, AREA LOCATIONS." Test ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. "CIVIL, SITE PLAN AND VICINITY MAP, AREA LOCATIONS." Test Area 1-125. Specifications No. ENG (NASA)-04-35363-1; Drawing No. 60-09-34; sheet 11. Ref. No. C-l. D.O. SERIES 1597/1. Approved for siting on 24 April 1962. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

Instrumentation and control building, architectural, floor plans. Specifications no. Eng043535572; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Instrumentation and control building, architectural, floor plans. Specifications no. Eng-04-353-55-72; Drawing No. 60-09-12' sheet 64 of 148; file no. 1321/15. Stamped: record drawing - as constructed. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

25. "TEST STAND 1A UTILIZED TO TEST THE ATLAS ICBM", ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. "TEST STAND 1-A UTILIZED TO TEST THE ATLAS ICBM", CROPPED OUT: "DIRECTORATE OF MISSILE CAPTIVE TEST, EDWARDS AFB." Photo no. 11,371 57; G-AFFTC 15 OCT 57. Looking southwest from below the stand. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

26. "TEST STAND, STRUCTURAL, FOUNDATION PLAN." Specifications No. ENG043535572; Drawing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. "TEST STAND, STRUCTURAL, FOUNDATION PLAN." Specifications No. ENG-04-353-55-72; Drawing No. 60-0912; sheet 25 of 148; file no. 1320/76. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

Rigor force responses of permeabilized fibres from fast and slow skeletal muscles of aged rats.

PubMed

Plant, D R; Lynch, G S

2001-09-01

1. Ageing is generally associated with a decline in skeletal muscle mass and strength and a slowing of muscle contraction, factors that impact upon the quality of life for the elderly. The mechanisms underlying this age-related muscle weakness have not been fully resolved. The purpose of the present study was to determine whether the decrease in muscle force as a consequence of age could be attributed partly to a decrease in the number of cross-bridges participating during contraction. 2. Given that the rigor force is proportional to the approximate total number of interacting sites between the actin and myosin filaments, we tested the null hypothesis that the rigor force of permeabilized muscle fibres from young and old rats would not be different. 3. Permeabilized fibres from the extensor digitorum longus (fast-twitch; EDL) and soleus (predominantly slow-twitch) muscles of young (6 months of age) and old (27 months of age) male F344 rats were activated in Ca2+-buffered solutions to determine force-pCa characteristics (where pCa = -log(10)[Ca2+]) and then in solutions lacking ATP and Ca2+ to determine rigor force levels. 4. The rigor forces for EDL and soleus muscle fibres were not different between young and old rats, indicating that the approximate total number of cross-bridges that can be formed between filaments did not decline with age. We conclude that the age-related decrease in force output is more likely attributed to a decrease in the force per cross-bridge and/or decreases in the efficiency of excitation-contraction coupling.

Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation.

PubMed

Khromov, A S; Wang, H; Choudhury, N; McDuffie, M; Herring, B P; Nakamoto, R; Owens, G K; Somlyo, A P; Somlyo, A V

2006-02-14

Cyclic nucleotides can relax smooth muscle without a change in [Ca2+]i, a phenomenon termed Ca2+ desensitization, contributing to vasodilation, gastrointestinal motility, and airway resistance. The physiological importance of telokin, a 17-kDa smooth muscle-specific protein and target for cyclic nucleotide-induced Ca2+ desensitization, was determined in telokin null mice bred to a congenic background. Telokin null ileal smooth muscle homogenates compared to wild type exhibited an approximately 30% decrease in myosin light-chain phosphatase (MLCP) activity, which was reflected in a significant leftward shift (up to 2-fold at pCa 6.3) of the Ca2+ force relationship accompanied by an increase in myosin light-chain phosphorylation. No difference in the Ca2+ force relationship occurred in telokin WT and knockout (KO) aortas, presumably reflecting the normally approximately 5-fold lower telokin content in aorta vs. ileum smooth muscle. Ca2+ desensitization of contractile force by 8-Br-cGMP was attenuated by 50% in telokin KO intestinal smooth muscle. The rate of force relaxation reflecting MLCP activity, in the presence of 50 microM 8-Br-cGMP, was also significantly slowed in telokin KO vs. WT ileum and was rescued by recombinant telokin. Normal thick filaments in telokin KO smooth muscles indicate that telokin is not required for filament formation or stability. Results indicate that a primary role of telokin is to modulate force through increasing MLCP activity and that this effect is further potentiated through phosphorylation by cGMP in telokin-rich smooth tissues.

20. Photographic copy of an asconstructed site plan for additions ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Photographic copy of an as-constructed site plan for additions to North Base: Job No. A(8-1), Military Construction, Materiel Command Flight Test Base, Muroc, California; Additional Construction, Location Plan, Sheet No. 2, October 1943. Reproduced from the holdings of the National Archives, Pacific Southwest Region - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

Improved model of hydrated calcium ion for molecular dynamics simulations using classical biomolecular force fields.

PubMed

Yoo, Jejoong; Wilson, James; Aksimentiev, Aleksei

2016-10-01

Calcium ions (Ca(2+) ) play key roles in various fundamental biological processes such as cell signaling and brain function. Molecular dynamics (MD) simulations have been used to study such interactions, however, the accuracy of the Ca(2+) models provided by the standard MD force fields has not been rigorously tested. Here, we assess the performance of the Ca(2+) models from the most popular classical force fields AMBER and CHARMM by computing the osmotic pressure of model compounds and the free energy of DNA-DNA interactions. In the simulations performed using the two standard models, Ca(2+) ions are seen to form artificial clusters with chloride, acetate, and phosphate species; the osmotic pressure of CaAc2 and CaCl2 solutions is a small fraction of the experimental values for both force fields. Using the standard parameterization of Ca(2+) ions in the simulations of Ca(2+) -mediated DNA-DNA interactions leads to qualitatively wrong outcomes: both AMBER and CHARMM simulations suggest strong inter-DNA attraction whereas, in experiment, DNA molecules repel one another. The artificial attraction of Ca(2+) to DNA phosphate is strong enough to affect the direction of the electric field-driven translocation of DNA through a solid-state nanopore. To address these shortcomings of the standard Ca(2+) model, we introduce a custom model of a hydrated Ca(2+) ion and show that using our model brings the results of the above MD simulations in quantitative agreement with experiment. Our improved model of Ca(2+) can be readily applied to MD simulations of various biomolecular systems, including nucleic acids, proteins and lipid bilayer membranes. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 752-763, 2016. © 2016 Wiley Periodicals, Inc.

A Photoionization Study of Cluster Species in a Supersonic Molecular Beam.

DTIC Science & Technology

1982-08-26

260 Code AFRPL MKPA Arlingon, VA 22217 Edwards AFB, CA 93523 Attn: Mr. 0. Siegel Attn: Dr. F. Roberto Office of Naval Research AFSC Western Office...of Naval Research 2 Scientific Research Eastern Central Regional Directorate of Chemical & Office Atmospheric Sciences 495 fumner Street Bolling Air...Directorate of Aero- San Francisco Area Office space Sciences * One Hallidie Plaza Suite 601 Bolling Air Force Base San Francisco, CA 94102 Washington

The Emission of Electrons and Positive Ions from Fracture of Materials.

DTIC Science & Technology

1981-04-01

260 Code AFRPL MKPA Arlingon, VA 22217 Edwards AFB, CA 93523 Attn: Mr. D. Siegel Attn: Dr. F. Roberto Office of Naval Research I AFSC Western Office...Office of Naval Research .2 Scientific Research Eastern Central Regional Directorate of Chemical & Office Atmospheric Sciences 495 Summer Street Bolling ...Research Directorate of Aero- San Francisco Area Office space Sciences One Hallidie Plaza Suite 601 Bolling Air Force Base San Francisco, CA 94102 Washington

Effect of Interfacial Bonding on the Strength of Adhesion of Elastomers II. Dissimilar Adherends.

DTIC Science & Technology

1981-02-02

260 Code AFRPL MKPA Arlingon, VA 22217 Edwards AFB, CA 93523 Attn: Mr. 0. Siegel Attn: Dr. F. Roberto Office of Naval Research AFSC Western Office...of Naval Research 2 Scientific Research Eastern Central Regional Directorate of Chemical & Office Atmospheric Sciences 495 Summer Street Bolling Air...Directorate of Aero- San Francisco Area Office space Sciences One Hallidie Plaza Suite 601 Bolling Air Force Base San Francisco, CA 94102 Washington

Military Review: The Professional Journal of the U.S. Army. May-June 2002

DTIC Science & Technology

2002-06-01

artisans formed corporations , and in the Middle Ages, tradesmen formed guilds.5 In the U.S. Army, recurring officers’ calls and lunchtime discussions...Analysis of Air-Based Mechanization and Vertical Envel- opment Concepts and Technologies, DB-321-A (Santa Monica, CA: RAND Corporation , 2001). 4. Colonel...AB-169-A/OSD (Santa Monica, CA: RAND Corporation , September 1997); and John Matsumura et al., Rapid Force Projection Technologies: Assessing the

8. INTERIOR, CONTROL AND INSTRUMENTATION ROOM. Looking southwest toward entrance ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. INTERIOR, CONTROL AND INSTRUMENTATION ROOM. Looking southwest toward entrance and inner blast door. - Edwards Air Force Base, South Base Sled Track, Firing & Control Blockhouse for 10,000-foot Track, South of Sled Track at midpoint of 20,000-foot track, Lancaster, Los Angeles County, CA

8. Credit PSR. Interior of Building 4305, looking west under ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Credit PSR. Interior of Building 4305, looking west under elliptical laminated wooden roof arches. Lower surfaces are ceilings of offices built within structure; cylindrical and rectangular ducts are for air conditioning. - Edwards Air Force Base, North Base, Unicon Portable Hangar, First & C Streets, Boron, Kern County, CA

13. WALKWAY FROM LAUNCHING PAD TO CABLE TUNNEL STAIRWELL, ALSO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. WALKWAY FROM LAUNCHING PAD TO CABLE TUNNEL STAIRWELL, ALSO SHOWING A PROTECTIVE BERM AT TOP LEFT, AND FIRING CONTROL BLOCKHOUSE 0545 AT TOP RIGHT. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

10. ENTRY STAIRWELL TO CABLE TUNNEL, ABOUT THREE QUARTERS THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. ENTRY STAIRWELL TO CABLE TUNNEL, ABOUT THREE QUARTERS THE DISTANCE TO THE SLED LAUNCHING PAD FROM THE FIRING CONTROL BLOCKHOUSE 0545. Looking west northwest. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

11. ENTRY STAIRWELL TO CABLE TUNNEL. REMAINS OF ELECTRICAL DISTRIBUTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. ENTRY STAIRWELL TO CABLE TUNNEL. REMAINS OF ELECTRICAL DISTRIBUTION STATIONS AT LEFT, TRACKSIDE CAMERA STAND AT FAR RIGHT. Looking northeast toward launch pad. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

Credit BG. Interior view of the building displays temporary wooden ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. Interior view of the building displays temporary wooden building construction, pump, and water piping arrangements. The well is currently used as an observation post for changes in ground water levels - Edwards Air Force Base, North Base, Well No. 2, East of Second Street, Boron, Kern County, CA

Credit BG. View looking northeast (42°) at storage building used ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. View looking northeast (42°) at storage building used to store equipment near southeast edge of aircraft apron in the vicinity of Building 4305 (Unicon Portable Hangar) - Edwards Air Force Base, North Base, Equipment Storage Building, East of Second Street, Boron, Kern County, CA

42. VIEW OF UMBILICAL MAST AND LAUNCH PAD FROM MST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. VIEW OF UMBILICAL MAST AND LAUNCH PAD FROM MST BASE. LAUNCHER IS BEHIND UMBILICAL MAST AND RAIL SYSTEM IS PARALLEL TO MAST ON RIGHT AND LEFT. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

13. LONG WEST WALL (LEFT) AND SHORT SOUTH WALL (RIGHT) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. LONG WEST WALL (LEFT) AND SHORT SOUTH WALL (RIGHT) OF AR-9, ALSO SHOWING MORE RECENT CONTROL ROOM BUILDING AT RIGHT. VIEW IS TO THE NORTHEAST. - Edwards Air Force Base, South Base, Rammed Earth Aircraft Dispersal Revetments, Western Shore of Rogers Dry Lake, Boron, Kern County, CA

Fropofol decreases force development in cardiac muscle.

PubMed

Ren, Xianfeng; Schmidt, William; Huang, Yiyuan; Lu, Haisong; Liu, Wenjie; Bu, Weiming; Eckenhoff, Roderic; Cammarato, Anthony; Gao, Wei Dong

2018-03-09

Supranormal contractile properties are frequently associated with cardiac diseases. Anesthetic agents, including propofol, can depress myocardial contraction. We tested the hypothesis that fropofol, a propofol derivative, reduces force development in cardiac muscles via inhibition of cross-bridge cycling and may therefore have therapeutic potential. Force and intracellular Ca 2+ ([Ca 2+ ] i ) transients of rat trabecular muscles were determined. Myofilament ATPase, actin-activated myosin ATPase, and velocity of actin filaments propelled by myosin were also measured. Fropofol dose dependently decreased force without altering [Ca 2+ ] i in normal and pressure-induced hypertrophied-hypercontractile muscles. Similarly, fropofol depressed maximum Ca 2+ -activated force ( F max ) and increased the [Ca 2+ ] i required for 50% activation at steady-state (Ca 50 ) without affecting the Hill coefficient in both intact and skinned cardiac fibers. The drug also depressed cardiac myofibrillar and actin-activated myosin ATPase activity. In vitro actin sliding velocity was significantly reduced when fropofol was introduced during rigor binding of cross-bridges. The data suggest that the depressing effects of fropofol on cardiac contractility are likely to be related to direct targeting of actomyosin interactions. From a clinical standpoint, these findings are particularly significant, given that fropofol is a nonanesthetic small molecule that decreases myocardial contractility specifically and thus may be useful in the treatment of hypercontractile cardiac disorders.-Ren, X., Schmidt, W., Huang, Y., Lu, H., Liu, W., Bu, W., Eckenhoff, R., Cammarato, A., Gao, W. D. Fropofol decreases force development in cardiac muscle.

CHARMM Force-Fields with Modified Polyphosphate Parameters Allow Stable Simulation of the ATP-Bound Structure of Ca(2+)-ATPase.

PubMed

Komuro, Yasuaki; Re, Suyong; Kobayashi, Chigusa; Muneyuki, Eiro; Sugita, Yuji

2014-09-09

Adenosine triphosphate (ATP) is an indispensable energy source in cells. In a wide variety of biological phenomena like glycolysis, muscle contraction/relaxation, and active ion transport, chemical energy released from ATP hydrolysis is converted to mechanical forces to bring about large-scale conformational changes in proteins. Investigation of structure-function relationships in these proteins by molecular dynamics (MD) simulations requires modeling of ATP in solution and ATP bound to proteins with accurate force-field parameters. In this study, we derived new force-field parameters for the triphosphate moiety of ATP based on the high-precision quantum calculations of methyl triphosphate. We tested our new parameters on membrane-embedded sarcoplasmic reticulum Ca(2+)-ATPase and four soluble proteins. The ATP-bound structure of Ca(2+)-ATPase remains stable during MD simulations, contrary to the outcome in shorter simulations using original parameters. Similar results were obtained with the four ATP-bound soluble proteins. The new force-field parameters were also tested by investigating the range of conformations sampled during replica-exchange MD simulations of ATP in explicit water. Modified parameters allowed a much wider range of conformational sampling compared with the bias toward extended forms with original parameters. A diverse range of structures agrees with the broad distribution of ATP conformations in proteins deposited in the Protein Data Bank. These simulations suggest that the modified parameters will be useful in studies of ATP in solution and of the many ATP-utilizing proteins.

143. GENERAL DYNAMICS SPACE SYSTEMS DIVISION SCHEDULE BOARD IN LUNCH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. GENERAL DYNAMICS SPACE SYSTEMS DIVISION SCHEDULE BOARD IN LUNCH ROOM (120), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

6. VIEW OF SLC3W CONTROL ROOM (ROOM 105) FROM ITS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. VIEW OF SLC-3W CONTROL ROOM (ROOM 105) FROM ITS SOUTHEAST CORNER - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

8. VIEW OF ROOM 101 (ASSEMBLY ROOM) FROM NORTHEAST CORNER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. VIEW OF ROOM 101 (ASSEMBLY ROOM) FROM NORTHEAST CORNER SHOWING FLEXIBLE AIR-CONDITIONING DUCT - Vandenberg Air Force Base, Space Launch Complex 3, Vehicle Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

54. DETAIL OF AIRCONDITIONING EXHAUST DUCTS ON NORTH FACE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

54. DETAIL OF AIR-CONDITIONING EXHAUST DUCTS ON NORTH FACE OF ERECT UMBILICAL MAST - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

83. DETAIL OF HONEYWELL AIRCONDITIONING CONTROLS IN SLC3E CONTROL ROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

83. DETAIL OF HONEYWELL AIR-CONDITIONING CONTROLS IN SLC-3E CONTROL ROOM - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

2. SOUTH FACE OF METEOROLOGICAL SHED (BLDG. 756) WITH METEOROLOGICAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. SOUTH FACE OF METEOROLOGICAL SHED (BLDG. 756) WITH METEOROLOGICAL DATA ACQUISITION TERMINAL (MDAT) INSIDE BUILDING - Vandenberg Air Force Base, Space Launch Complex 3, Meteorological Shed & Tower, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

133. NITROGEN SUPPLY PANEL ON SOUTH WALL OF CONTROL ROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

133. NITROGEN SUPPLY PANEL ON SOUTH WALL OF CONTROL ROOM (114), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

56. VIEW OF LAUNCHER FROM SOUTHWEST. NITROGEN CONTROL UNIT ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

56. VIEW OF LAUNCHER FROM SOUTHWEST. NITROGEN CONTROL UNIT ON RIGHT; UMBILICAL MAST ON LEFT. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

143. MOBILE HIGH PRESSURE NITROGEN CART STORED IN CONTROL ROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. MOBILE HIGH PRESSURE NITROGEN CART STORED IN CONTROL ROOM (214), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

74. LIQUID NITROGEN TANK, REGULATOR VALVES, AND PRESSURE GAUGES FOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

74. LIQUID NITROGEN TANK, REGULATOR VALVES, AND PRESSURE GAUGES FOR LIQUID NITROGEN PUMPING STATION - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

137. VALVES ON SOUTH WALL OF LIQUID NITROGEN CONTROL ROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

137. VALVES ON SOUTH WALL OF LIQUID NITROGEN CONTROL ROOM (115), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

9. WEST FACE OF OLD THEODOLITE BUILDING; WEST FACE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. WEST FACE OF OLD THEODOLITE BUILDING; WEST FACE OF EAST PHOTO TOWER IN BACKGROUND - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

10. Credit BG. Interior of control and observation room at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Credit BG. Interior of control and observation room at Control and Recording Center Building 4221/E-22. - Jet Propulsion Laboratory Edwards Facility, Control & Recording Center, Edwards Air Force Base, Boron, Kern County, CA

78. PIPING CHANNEL FOR FUEL LOADING, FUEL TOPPING, COMPRESSED AIR, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

78. PIPING CHANNEL FOR FUEL LOADING, FUEL TOPPING, COMPRESSED AIR, GASEOUS NITROGEN, AND HELIUM - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Late Quaternary Productivity Records from Coccolith Sr/Ca

NASA Astrophysics Data System (ADS)

Stoll, H. M.; Burke, A.; Mejia Ramirez, L. M.; Shimizu, N.; Ziveri, P. P. I.

2014-12-01

The Sr/Ca of coccoliths has been proposed as an indicator of productivity on the basis of correlation with export production in sediment traps and across upwelling productivity gradients, although the mechanism responsable for this relationship is not clear. For diverse oceanographic settings in the Late Quaternary, we compare coccolith Sr/Ca productivity records with those of other productivity indicators and proxies for mechanisms of productivity forcing. For the Somalia Basin in the Arabian Sea, coccolith Sr/Ca shows a large variation coherent with precessional forcing of wind strength as a mechanism for productivity regulation. During the glacial, the Sr/Ca peak is decoupled from productivity indicators based on organic C accumulation rate. For the Northern Bay of Bengal, coccolith Sr/Ca, Ba/Ti, and relative abundance of G. bulloides, all suggest greater productivity during the interglacial periods, consisted with Nd isotopic evidence for greater riverine nutrient inputs. In the Andaman Sea, coccolith Sr/Ca is highest during precessional maxima in the summer monsoon, consistent with proxies for chemical weathering in the Irawaddy rivershed. In the Eastern Mediterranean, coccolith Sr/Ca is on average low, and peaks during the E. Holocene interval characterized by deposition of sapropel S1. The peak in Sr/Ca however is comparable to the level maintained throughout the Holocene in the Western Mediterranean, where no sapropel occurs, implicating deepwater oxygen levels as a significant contributor to sapropel formation. Finally, on the Agulhas Bank, minima in coccolith Sr/Ca occur during obliquity minima which are periods of anomalous equatorward deposition of IRD in the Southern Ocean. Northward explansion of the westerly wind field during these cold intervals, block upwelling on the Agulhas Bank and result in low productivity.

Enhancement of force generated by individual myosin heads in skinned rabbit psoas muscle fibers at low ionic strength.

PubMed

Sugi, Haruo; Abe, Takahiro; Kobayashi, Takakazu; Chaen, Shigeru; Ohnuki, Yoshiki; Saeki, Yasutake; Sugiura, Seiryo

2013-01-01

Although evidence has been presented that, at low ionic strength, myosin heads in relaxed skeletal muscle fibers form linkages with actin filaments, the effect of low ionic strength on contraction characteristics of Ca(2+)-activated muscle fibers has not yet been studied in detail. To give information about the mechanism of muscle contraction, we have examined the effect of low ionic strength on the mechanical properties and the contraction characteristics of skinned rabbit psoas muscle fibers in both relaxed and maximally Ca(2+)-activated states. By progressively decreasing KCl concentration from 125 mM to 0 mM (corresponding to a decrease in ionic strength μ from 170 mM to 50 mM), relaxed fibers showed changes in mechanical response to sinusoidal length changes and ramp stretches, which are consistent with the idea of actin-myosin linkage formation at low ionic strength. In maximally Ca(2+)-activated fibers, on the other hand, the maximum isometric force increased about twofold by reducing KCl concentration from 125 to 0 mM. Unexpectedly, determination of the force-velocity curves indicated that, the maximum unloaded shortening velocity Vmax, remained unchanged at low ionic strength. This finding indicates that the actin-myosin linkages, which has been detected in relaxed fibers at low ionic strength, are broken quickly on Ca(2+) activation, so that the linkages in relaxed fibers no longer provide any internal resistance against fiber shortening. The force-velocity curves, obtained at various levels of steady Ca(2+)-activated isometric force, were found to be identical if they are normalized with respect to the maximum isometric force. The MgATPase activity of muscle fibers during isometric force generation was found not to change appreciably at low ionic strength despite the two-fold increase in Ca(2+)-activated isometric force. These results can be explained in terms of enhancement of force generated by individual myosin heads, but not by any changes in kinetic properties of cyclic actin-myosin interaction.

Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice.

PubMed

Bruton, Joseph D; Place, Nicolas; Yamada, Takashi; Silva, José P; Andrade, Francisco H; Dahlstedt, Anders J; Zhang, Shi-Jin; Katz, Abram; Larsson, Nils-Göran; Westerblad, Håkan

2008-01-01

Skeletal muscle often shows a delayed force recovery after fatiguing stimulation, especially at low stimulation frequencies. In this study we focus on the role of reactive oxygen species (ROS) in this fatigue-induced prolonged low-frequency force depression. Intact, single muscle fibres were dissected from flexor digitorum brevis (FDB) muscles of rats and wild-type and superoxide dismutase 2 (SOD2) overexpressing mice. Force and myoplasmic free [Ca(2+)] ([Ca(2+)](i)) were measured. Fibres were stimulated at different frequencies before and 30 min after fatigue induced by repeated tetani. The results show a marked force decrease at low stimulation frequencies 30 min after fatiguing stimulation in all fibres. This decrease was associated with reduced tetanic [Ca(2+)](i) in wild-type mouse fibres, whereas rat fibres and mouse SOD2 overexpressing fibres instead displayed a decreased myofibrillar Ca(2+) sensitivity. The SOD activity was approximately 50% lower in wild-type mouse than in rat FDB muscles. Myoplasmic ROS increased during repeated tetanic stimulation in rat fibres but not in wild-type mouse fibres. The decreased Ca(2+) sensitivity in rat fibres could be partially reversed by application of the reducing agent dithiothreitol, whereas the decrease in tetanic [Ca(2+)](i) in wild-type mouse fibres was not affected by dithiothreitol or the antioxidant N-acetylcysteine. In conclusion, we describe two different causes of fatigue-induced prolonged low-frequency force depression, which correlate to differences in SOD activity and ROS metabolism. These findings may have clinical implications since ROS-mediated impairments in myofibrillar function can be counteracted by reductants and antioxidants, whereas changes in SR Ca(2+) handling appear more resistant to interventions.

Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle

PubMed Central

Brotto, Leticia S.; Bougoin, Sylvain; Nosek, Thomas M.; Reid, Michael; Hardin, Brian; Pan, Zui; Ma, Jianjie; Parness, Jerome

2011-01-01

Muscle atrophy alone is insufficient to explain the significant decline in contractile force of skeletal muscle during normal aging. One contributing factor to decreased contractile force in aging skeletal muscle could be compromised excitation-contraction (E-C) coupling, without sufficient available Ca2+ to allow for repetitive muscle contractility, skeletal muscles naturally become weaker. Using biophysical approaches, we previously showed that store-operated Ca2+ entry (SOCE) is compromised in aged skeletal muscle but not in young ones. While important, a missing component from previous studies is whether or not SOCE function correlates with contractile function during aging. Here we test the contribution of extracellular Ca2+ to contractile function of skeletal muscle during aging. First, we demonstrate graded coupling between SR Ca2+ release channel-mediated Ca2+ release and activation of SOCE. Inhibition of SOCE produced significant reduction of contractile force in young skeletal muscle, particularly at high frequency stimulation, and such effects were completely absent in aged skeletal muscle. Our data indicate that SOCE contributes to the normal physiological contractile response of young healthy skeletal muscle and that defective extracellular Ca2+ entry through SOCE contributes to the reduced contractile force characteristic of aged skeletal muscle. PMID:21666285

Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.

PubMed

Thornton, Angela M; Zhao, Xiaoli; Weisleder, Noah; Brotto, Leticia S; Bougoin, Sylvain; Nosek, Thomas M; Reid, Michael; Hardin, Brian; Pan, Zui; Ma, Jianjie; Parness, Jerome; Brotto, Marco

2011-06-01

Muscle atrophy alone is insufficient to explain the significant decline in contractile force of skeletal muscle during normal aging. One contributing factor to decreased contractile force in aging skeletal muscle could be compromised excitation-contraction (E-C) coupling, without sufficient available Ca(2+) to allow for repetitive muscle contractility, skeletal muscles naturally become weaker. Using biophysical approaches, we previously showed that store-operated Ca(2+) entry (SOCE) is compromised in aged skeletal muscle but not in young ones. While important, a missing component from previous studies is whether or not SOCE function correlates with contractile function during aging. Here we test the contribution of extracellular Ca(2+) to contractile function of skeletal muscle during aging. First, we demonstrate graded coupling between SR Ca(2+) release channel-mediated Ca(2+) release and activation of SOCE. Inhibition of SOCE produced significant reduction of contractile force in young skeletal muscle, particularly at high frequency stimulation, and such effects were completely absent in aged skeletal muscle. Our data indicate that SOCE contributes to the normal physiological contractile response of young healthy skeletal muscle and that defective extracellular Ca(2+) entry through SOCE contributes to the reduced contractile force characteristic of aged skeletal muscle.

8. X15 ENGINE TESTING. A color print showing the engine ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. X-15 ENGINE TESTING. A color print showing the engine during test firing. View from the rear of the test stand looking northwest. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

Credit PSR. View looks east southeast (118°) across foundations of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit PSR. View looks east southeast (118°) across foundations of North Base Administration Building (originally numbered T-50) toward Building 4318 (Warehouse) and Building 4305 (Unicon Portable Hangar). Building 4401 (Hangar No. 1) appears in extreme left background - Edwards Air Force Base, North Base, Administration Building T-50, D Street, Boron, Kern County, CA

Role of TRPC1 channel in skeletal muscle function

PubMed Central

Zanou, Nadège; Shapovalov, Georges; Louis, Magali; Tajeddine, Nicolas; Gallo, Chiara; Van Schoor, Monique; Anguish, Isabelle; Cao, My Linh; Schakman, Olivier; Dietrich, Alexander; Lebacq, Jean; Ruegg, Urs; Roulet, Emmanuelle; Birnbaumer, Lutz

2010-01-01

Skeletal muscle contraction is reputed not to depend on extracellular Ca2+. Indeed, stricto sensu, excitation-contraction coupling does not necessitate entry of Ca2+. However, we previously observed that, during sustained activity (repeated contractions), entry of Ca2+ is needed to maintain force production. In the present study, we evaluated the possible involvement of the canonical transient receptor potential (TRPC)1 ion channel in this entry of Ca2+ and investigated its possible role in muscle function. Patch-clamp experiments reveal the presence of a small-conductance channel (13 pS) that is completely lost in adult fibers from TRPC1−/− mice. The influx of Ca2+ through TRPC1 channels represents a minor part of the entry of Ca2+ into muscle fibers at rest, and the activity of the channel is not store dependent. The lack of TRPC1 does not affect intracellular Ca2+ concentration ([Ca2+]i) transients reached during a single isometric contraction. However, the involvement of TRPC1-related Ca2+ entry is clearly emphasized in muscle fatigue. Indeed, muscles from TRPC1−/− mice stimulated repeatedly progressively display lower [Ca2+]i transients than those observed in TRPC1+/+ fibers, and they also present an accentuated progressive loss of force. Interestingly, muscles from TRPC1−/− mice display a smaller fiber cross-sectional area, generate less force per cross-sectional area, and contain less myofibrillar proteins than their controls. They do not present other signs of myopathy. In agreement with in vitro experiments, TRPC1−/− mice present an important decrease of endurance of physical activity. We conclude that TRPC1 ion channels modulate the entry of Ca2+ during repeated contractions and help muscles to maintain their force during sustained repeated contractions. PMID:19846750

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms

PubMed Central

Iorga, Bogdan; Schwanke, Kristin; Weber, Natalie; Wendland, Meike; Greten, Stephan; Piep, Birgit; dos Remedios, Cristobal G.; Martin, Ulrich; Zweigerdt, Robert; Kraft, Theresia; Brenner, Bernhard

2018-01-01

Characterizing the contractile function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is key for advancing their utility for cellular disease models, promoting cell based heart repair, or developing novel pharmacological interventions targeting cardiac diseases. The aim of the present study was to understand whether steady-state and kinetic force parameters of β-myosin heavy chain (βMyHC) isoform-expressing myofibrils within human embryonic stem cell-derived cardiomyocytes (hESC-CMs) differentiated in vitro resemble those of human ventricular myofibrils (hvMFs) isolated from adult donor hearts. Contractile parameters were determined using the same micromechanical method and experimental conditions for both types of myofibrils. We identified isoforms and phosphorylation of main sarcomeric proteins involved in the modulation of force generation of both, chemically demembranated hESC-CMs (d-hESC-CMs) and hvMFs. Our results indicate that at saturating Ca2+ concentration, both human-derived contractile systems developed forces with similar rate constants (0.66 and 0.68 s−1), reaching maximum isometric force that was significantly smaller for d-hESC-CMs (42 kPa) than for hvMFs (94 kPa). At submaximal Ca2+-activation, where intact cardiomyocytes normally operate, contractile parameters of d-hESC-CMs and hvMFs exhibited differences. Ca2+ sensitivity of force was higher for d-hESC-CMs (pCa50 = 6.04) than for hvMFs (pCa50 = 5.80). At half-maximum activation, the rate constant for force redevelopment was significantly faster for d-hESC-CMs (0.51 s−1) than for hvMFs (0.28 s−1). During myofibril relaxation, kinetics of the slow force decay phase were significantly faster for d-hESC-CMs (0.26 s−1) than for hvMFs (0.21 s−1), while kinetics of the fast force decay were similar and ~20x faster. Protein analysis revealed that hESC-CMs had essentially no cardiac troponin-I, and partially non-ventricular isoforms of some other sarcomeric proteins, explaining the functional discrepancies. The sarcomeric protein isoform pattern of hESC-CMs had features of human cardiomyocytes at an early developmental stage. The study indicates that morphological and ultrastructural maturation of βMyHC isoform-expressing hESC-CMs is not necessarily accompanied by ventricular-like expression of all sarcomeric proteins. Our data suggest that hPSC-CMs could provide useful tools for investigating inherited cardiac diseases affecting contractile function during early developmental stages. PMID:29403388

33 CFR 165.1184 - Safety Zone; Coast Guard Use of Force Training Exercises, San Pablo Bay, CA.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., CA. (a) Location. This safety zone will apply to the navigable waters in the San Pablo Bay, and will... Force Training Exercises, San Pablo Bay, CA. 165.1184 Section 165.1184 Navigation and Navigable Waters... Coast Guard will notify the public via a Broadcast Notice to Mariners prior to the activation of this...

33 CFR 165.1184 - Safety Zone; Coast Guard Use of Force Training Exercises, San Pablo Bay, CA.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., CA. (a) Location. This safety zone will apply to the navigable waters in the San Pablo Bay, and will... Force Training Exercises, San Pablo Bay, CA. 165.1184 Section 165.1184 Navigation and Navigable Waters... Coast Guard will notify the public via a Broadcast Notice to Mariners prior to the activation of this...

33 CFR 165.1184 - Safety Zone; Coast Guard Use of Force Training Exercises, San Pablo Bay, CA.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., CA. (a) Location. This safety zone will apply to the navigable waters in the San Pablo Bay, and will... Force Training Exercises, San Pablo Bay, CA. 165.1184 Section 165.1184 Navigation and Navigable Waters... Coast Guard will notify the public via a Broadcast Notice to Mariners prior to the activation of this...

33 CFR 165.1184 - Safety Zone; Coast Guard Use of Force Training Exercises, San Pablo Bay, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., CA. (a) Location. This safety zone will apply to the navigable waters in the San Pablo Bay, and will... Force Training Exercises, San Pablo Bay, CA. 165.1184 Section 165.1184 Navigation and Navigable Waters... Coast Guard will notify the public via a Broadcast Notice to Mariners prior to the activation of this...

Root negative gravitropism is accompanied with displacing of columella amyloplasts to the statocyte upper longitudinal cell wall

NASA Astrophysics Data System (ADS)

Kordyum, Elizabeth; Sobol, Margaryta; Kalinina, Yana; Bogatina, Nina; Kondrachuk, Alexander

Recently it was shown that roots reveal negative gravitropism in the weak combined magnetic field (CMF) with the frequency resonance to the cyclotron frequency of Ca2+ ions. A negative gravitropic reaction in the CMF occurs by a usual physiological process. Experiments in the CMF confirmed that gravitropism is plastid-based and Ca2+ ions participate in this process. Unlike control, amyloplasts-statoliths are not displacing on the lower side of a gravistimulated root but tend to group in the center of a statocyte during 30 min under gravistimulation in the CMF. In an hour of gravistimulation, they are localized near one of the statocyte longitudinal wall. Now we determined that amyloplasts are localized along the statocyte upper longitudinal side. It is of a special interest that a root is bending to the same direction with displacing of amyloplasts: in positive gravitropism - downwards, in negative gravitropism - upwards. On the basis of the obtained data there is a question, what forces promote displacing of amyloplasts against a gravitational vector? In the paper, three possible explanations are discussed: 1) CMF + Ca2+ action on the distribution of elastic forces in cytoskeleton, 2) CMF + Ca2+ action on the distribution of electric field in statocytes, and 3) CMF action on energy and direction of Ca2+ ion rotation according to the ion cyclotron resonance model that can lead to paradoxical Ca2+ redistribution.

Release of Applied Mechanical Loading Stimulates Intercellular Calcium Waves in Drosophila Wing Discs.

PubMed

Narciso, Cody E; Contento, Nicholas M; Storey, Thomas J; Hoelzle, David J; Zartman, Jeremiah J

2017-07-25

Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca 2+ ) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca 2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ's mechanical stress environment and biochemical signaling under genetic and chemical perturbations. This method enabled us to define the essential conditions for generating organ-scale intercellular Ca 2+ waves in Drosophila wing discs that are also observed in vivo during organ development. We discovered that mechanically induced intercellular Ca 2+ waves require fly extract growth serum as a chemical stimulus. Using the chip-based regulated environment for microorgans, we demonstrate that not the initial application but instead the release of mechanical loading is sufficient, but not necessary, to initiate intercellular Ca 2+ waves. The Ca 2+ response depends on the prestress intercellular Ca 2+ activity and not on the magnitude or duration of the mechanical stimulation applied. Mechanically induced intercellular Ca 2+ waves rely on IP 3 R-mediated Ca 2+ -induced Ca 2+ release and propagation through gap junctions. Thus, intercellular Ca 2+ waves in developing epithelia may be a consequence of stress dissipation during organ growth. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Calcium Sensitivity, Force Frequency Relationship and Cardiac Troponin I: Critical Role of PKA and PKC Phosphorylation Sites

PubMed Central

Ramirez-Correa, Genaro A.; Cortassa, Sonia; Stanley, Brian; Gao, Wei Dong; Murphy, Anne M.

2010-01-01

Transgenic models with pseudo phosphorylation mutants of troponin I, PKA sites at Ser 22 and 23 (cTnIDD22,23 mice) or PKC sites at Ser 42 and 44 (cTnIAD22,23DD42,44) displayed differential force-frequency relationships and afterload relaxation delay in vivo. We hypothesized that cTnI PKA and PKC phospho-mimics impact cardiac muscle rate-related developed twitch force and relaxation kinetics in opposite directions. cTnIDD22,23 transgenic mice produces a force frequency relationship (FFR) equivalent to control NTG albeit at lower peak [Ca2+]i, while cTnIAD22,23DD42,44 TG mice had a flat FFR with normal peak systolic [Ca2+]i, thus suggestive of diminished responsiveness to [Ca2+]i at higher frequencies. Force-[Ca2+]i hysteresis analysis revealed that cTnIDD22,23 mice have a combined enhanced myofilament calcium peak response with an enhanced slope of force development and decline per unit of [Ca2+]i, whereas cTnIAD22,23DD42,44 transgenic mice showed the opposite. The computational ECME model predicts that the TG lines may be distinct from each other due to different rate constants for association/dissociation of Ca2+ at the regulatory site of cTnC. Our data indicate that cTnI phosphorylation at PKA sites plays a critical role in the FFR by increasing relative myofilament responsiveness, and results in a distinctive transition between activation and relaxation, as displayed by Force-[Ca2+]i hysteresis loops. These findings may have important implications for understanding the specific contribution of cTnI to β-adrenergic inotropy and lusitropy and to adverse contractile effects of PKC activation, which is relevant during heart failure development. PMID:20083117

104. SIGNAL CONDITIONERS FOR BOOSTER INSTRUMENTATION, SOUTHWEST SIDE OF LANDLINE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

104. SIGNAL CONDITIONERS FOR BOOSTER INSTRUMENTATION, SOUTHWEST SIDE OF LANDLINE INSTRUMENTATION ROOM (106), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

11. CENTRAL ATLAS CONTROL CONSOLE IN SLC3W CONTROL ROOM. COMMUNICATIONS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. CENTRAL ATLAS CONTROL CONSOLE IN SLC-3W CONTROL ROOM. COMMUNICATIONS HEADSETS IN FOREGROUND. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

76. DETAIL OF AIRCONDITIONING DUCT BETWEEN PORTABLE PAYLOAD AIRCONDITIONING SYSTEM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

76. DETAIL OF AIR-CONDITIONING DUCT BETWEEN PORTABLE PAYLOAD AIR-CONDITIONING SYSTEM AND LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

10. PARTIAL VIEW OF SOUTH FACE OF MST AND BRIDGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. PARTIAL VIEW OF SOUTH FACE OF MST AND BRIDGE CRANE MOVED TO ITS SOUTHERN LIMIT - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

11. PARTIAL VIEW OF NORTH FACE OF MST AND BRIDGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. PARTIAL VIEW OF NORTH FACE OF MST AND BRIDGE CRANE MOVED TO ITS NORTHERN LIMIT - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

105. CABLE TRAY TUNNEL ENTRANCE TO LSB (BLDG. 770) AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

105. CABLE TRAY TUNNEL ENTRANCE TO LSB (BLDG. 770) AT SOUTH END OF LANDLINE INSTRUMENTATION ROOM - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

118. INTERIOR OF CABLE DISTRIBUTION CABINETS ON NORTHEAST SIDE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

118. INTERIOR OF CABLE DISTRIBUTION CABINETS ON NORTHEAST SIDE OF LANDLINE INSTRUMENTATION ROOM (206), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

124. FIRE ALARM SYSTEM PANEL AT WEST SIDE OF SOUTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

124. FIRE ALARM SYSTEM PANEL AT WEST SIDE OF SOUTH WALL, TRANSFORMER ROOM (112), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

141. NITROGEN TEST PANEL ON EAST WALL OF AGENA TRANSFER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

141. NITROGEN TEST PANEL ON EAST WALL OF AGENA TRANSFER AREA SHELTER (117A), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

99. LIQUID OXYGEN LINE AND SAMPLING VALVE FOR RAPIDLOAD ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

99. LIQUID OXYGEN LINE AND SAMPLING VALVE FOR RAPID-LOAD ON WEST SIDE OF SKID 9A - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

138. LIQUID NITROGEN INSTRUMENT PANEL ON EAST WALL OF LIQUID ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

138. LIQUID NITROGEN INSTRUMENT PANEL ON EAST WALL OF LIQUID NITROGEN CONTROL ROOM (115), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

93. VIEW OF LIQUID OXYGEN TOPPING TANK BEHIND SKID 9 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

93. VIEW OF LIQUID OXYGEN TOPPING TANK BEHIND SKID 9 AND GASEOUS NITROGEN TANKS BEHIND SKID 7 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Interior, building 1205, view to west showing roof truss system, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior, building 1205, view to west showing roof truss system, 90 mm lens plus electronic flash fill lighting. - Travis Air Force Base, Readiness Maintenance Hangar, W Street, Air Defense Command Readiness Area, Fairfield, Solano County, CA

The Offload of JPSS-1 and ICESAT Interstages NASA Hangar 836 Vandenberg AFB, CA

NASA Image and Video Library

2016-04-25

Technicians offload the interstage of a Delta II rocket inside NASA Hangar 836 at Vandenberg Air Force Base in California, for preparations to launch the Joint Polar Satellite System spacecraft in 2017.

71. DETAIL OF NITROGEN GAS STORAGE TANKS AND TRANSFER TUBING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

71. DETAIL OF NITROGEN GAS STORAGE TANKS AND TRANSFER TUBING ON SLC-3W LIQUID OXYGEN APRON - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

6. DETAIL OF HIGHPRESSURE COMPRESSED AIR HOSE IN SOUTHWEST CORNER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. DETAIL OF HIGH-PRESSURE COMPRESSED AIR HOSE IN SOUTHWEST CORNER OF SHIPPING AND RECEIVING ROOM (109) - Vandenberg Air Force Base, Space Launch Complex 3, Vehicle Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Role of Amines in Adhesion of Polybutadiene to Glass Substrates. II. Reactions of Amines with Triethylsilanol and/or Fumed Silica.

DTIC Science & Technology

1982-10-01

Schmidt I Dr. F. Roberto 1 Assistant Secretary of the Navy Code AFRPL MKPA (RE, and S) Room SE 731 Edwards AFE, CA 93523 Pentagon Washington, D.C...Force Office of’Sctentific Office of Naval Research Research odie 43 vDirectorate of Chemical Sciences CodeA l V 22217 " Bolling Air Force Base Arlington

14. "SITE WORK, CIVIL, SITE PLAN." Test Area 1120. Specifications ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. "SITE WORK, CIVIL, SITE PLAN." Test Area 1-120. Specifications No. OC2-55-72; Drawing No. 60-09-12; sheet 7 of 148; file no. 1320/58, Rev. C. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338 Rev. C, Date: 16 April 1957. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

9. "SANTA FE RAILWAY SPUR TO OPERATIONAL AREA, DIRECTORATE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. "SANTA FE RAILWAY SPUR TO OPERATIONAL AREA, DIRECTORATE OF MISSILE CAPTIVE TEST, EDWARDS AFB"; Photo no. "11,381 57; G-AFFTC 18 SEPT 57". Test Area 1-115. Photo shows engine no. 712 pulling one car. The superstructure of Test Stand 1-4 is prominent in the background. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

3. "LAUNCH SILOS; AREA PAVING AND GRADING PLAN." Specifications No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. "LAUNCH SILOS; AREA PAVING AND GRADING PLAN." Specifications No. ENG-04-353-59-73; Drawing No. 5841C-11; D.O. SERIES AW-1525/17; Stamped: RECORD DRAWING AS CONSTRUCTED. Below stamp: Contract No. 6601, Date 18 Sep 59. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

4. "LAUNCH SILOS, EQUIPMENT ROOMS SECTIONS AND DETAILS." Specifications ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. "LAUNCH SILOS, EQUIPMENT ROOMS - SECTIONS AND DETAILS." Specifications No. ENG-04-353-59-73; Drawing No. 5841S-5; D.O. SERIES AW-1525/28; Stamped: RECORD DRAWING AS CONSTRUCTED. Below Stamp: Contract No. 6601, Date 18 Sep 59. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

Capillary Discharge Thruster Experiments and Modeling (Briefing Charts)

DTIC Science & Technology

2016-06-01

Martin1 ERC INC.1, IN-SPACE PROPULSION BRANCH, AIR FORCE RESEARCH LABORATORY EDWARDS AIR FORCE BASE, CA USA Electric propulsion systems June 2016... PROPULSION MODELS & EXPERIMENTS Spacecraft Propulsion Relevant Plasma: From hall thrusters to plumes and fluxes on components Complex reaction physics i.e... Propulsion Plumes FRC Chamber Environment R.S. MARTIN (ERC INC.) DISTRIBUTION A: APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED; PA# 16279 3 / 30 ELECTRIC

5. "LAUNCH SILOS; EQUIP. ROOM; SECTIONS AND DETAILS." Specifications No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. "LAUNCH SILOS; EQUIP. ROOM; SECTIONS AND DETAILS." Specifications No. ENG-04-353-59-73; Drawing No. 5841S-6; D.O. SERIES AW-1525/29; Stamped: RECORD DRAWING AS CONSTRUCTED. Below stamp: Contract No. 6601, Date 18 Sep 59. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

1. TEST STAND 1A ENVIRONS, SHOWING WEST SIDE OF TEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. TEST STAND 1-A ENVIRONS, SHOWING WEST SIDE OF TEST STAND 1-A, RP1 COMBINED FUEL STORAGE TANK FARM BELOW WATER TANKS ON HILLSIDE TO LEFT, AND TEST STAND 1-B IN DISTANCE AT RIGHT. Looking east. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

3. TEST AREA 1115, OVERVIEW. AT RIGHT IS BUILDING 8647, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. TEST AREA 1-115, OVERVIEW. AT RIGHT IS BUILDING 8647, TEST STAND 1-4. AT LEFT CENTER, IN THE MIDDLE DISTANCE, IS BUILDING 8668, INSTRUMENTATION AND CONTROL BUILDING FOR TEST AREA 1-115. Looking east from the deck of Test Stand 1-5. (PANORAMA 2/2) - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

8. "TEST STAND, ARCHITECTURAL, FLOOR PLANS AND SCHEDULES." Specifications No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. "TEST STAND, ARCHITECTURAL, FLOOR PLANS AND SCHEDULES." Specifications No. ENG-04-353-55-72; Drawing No. 60-0912; sheet 22 of 148; file no. 1320/73. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

10. "ARCHITECTURAL, SECTIONS AND DETAILS." Specifications No. ENG043535572; Drawing No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. "ARCHITECTURAL, SECTIONS AND DETAILS." Specifications No. ENG-04-353-55-72; Drawing No. 60-09-12; sheet 23 of 148; file no. 1320/74. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

5. "UNDERGROUND CONTROL ROOM AT TEST STAND 1A, DIRECTORATE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. "UNDERGROUND CONTROL ROOM AT TEST STAND 1-A, DIRECTORATE OF MISSILE CAPTIVE TEST, EDWARDS AFB, 15 JAN 58, 3097.58." Two men working in the control room. Photo no. "3097 58; G-AFFTC 15 JAN 58, T.S. 1-A Control". - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

Automated Carrier Landing of an Unmanned Combat Aerial Vehicle Using Dynamic Inversion

DTIC Science & Technology

2007-06-01

17 CN normal force coefficient . . . . . . . . . . . . . . . . . . . . 17 CA axial force coefficient...slug·ft2 Ixzb 0 slug·ft2 The aircraft has a single engine inlet for a single, centerline mounted turbofan engine. For purposes of this research, the...assumed to remain constant for each simulation run and were based on an assumed 10% fuel load with full weapons [2]. The rest of these values were

Contractile properties of early human embryonic stem cell-derived cardiomyocytes: beta-adrenergic stimulation induces positive chronotropy and lusitropy but not inotropy.

PubMed

Pillekamp, Frank; Haustein, Moritz; Khalil, Markus; Emmelheinz, Markus; Nazzal, Rewa; Adelmann, Roland; Nguemo, Filomain; Rubenchyk, Olga; Pfannkuche, Kurt; Matzkies, Matthias; Reppel, Michael; Bloch, Wilhelm; Brockmeier, Konrad; Hescheler, Juergen

2012-08-10

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) provide the unique opportunity to study the very early development of the human heart. The aim of this study was to investigate the effect of calcium and beta-adrenergic stimulation on the contractile properties of early hESC-CMs. Beating clusters containing hESC-CMs were co-cultured in vitro with noncontractile slices of neonatal murine ventricles. After 5-7 days, when beating clusters had integrated morphologically into the damaged tissue, isometric force measurements were performed during spontaneous beating as well as during electrical field stimulation. Spontaneous beating stopped when extracellular calcium ([Ca²⁺](ec)) was removed or after administration of the Ca²⁺ channel blocker nifedipine. During field stimulation at a constant rate, the developed force increased with incremental concentrations of [Ca²⁺](ec). During spontaneous beating, rising [Ca²⁺](ec) increased beating rate and developed force up to a [Ca²⁺](ec) of 2.5 mM. When [Ca²⁺](ec) was increased further, spontaneous beating rate decreased, whereas the developed force continued to increase. The beta-adrenergic agonist isoproterenol induced a dose-dependent increase of the frequency of spontaneous beating; however, it did not significantly change the developed force during spontaneous contractions or during electrical stimulation at a constant rate. Force developed by early hESC-CMs depends on [Ca²⁺](ec) and on the L-type Ca²⁺ channel. The lack of an inotropic reaction despite a pronounced chronotropic response after beta-adrenergic stimulation most likely indicates immaturity of the sarcoplasmic reticulum. For cell-replacement strategies, further maturation of cardiac cells has to be achieved either in vitro before or in vivo after transplantation.

Effect of Hindlimb Unloading on Rat Soleus Fiber Force, Stiffness, and Calcium Sensitivity

NASA Technical Reports Server (NTRS)

McDonald Kerry S.; Fitts, Robert H.

1995-01-01

The purpose of this study was to examine the time course of change in soleus muscle fiber peak force (N), tension (P(sub 0), kN/sq m), elastic modulus (E(sub 0)), and force-pCa and stiffness - pCa relationships. After 1, 2, or 3 wk of Hindlimb Unloading (HU), single fibers were isolated and placed between a motor arm and a transducer, and fiber diameter, peak absolute force, P(sub 0), E(sub 0), and force-pCa and stiffness-pca relationships were characterized. One week of HU resulted in a significant reduction in fiber diameter (68 +/- 2 vs. 57 +/- 1 micrometer), force (3.59 +/- 0.15 vs. 2.19 +/- 0.12 x 10(exp -4) N), P(sub 0) (102 +/- 4 vs. 85 +/- 2 kN/sq m), and E(sub 0) (1.96 +/- 0.12 vs. 1.37 +/- 0.13 X 10(exp 7) N/sq m) and 2 wk of HU caused a further decline in fiber diameter (45 +/- 1 micrometer), force (1.31 +/- 0.06 x 10(exp -4) N), and E(sub 0)(0.96 +/- 0.09 x 10(exp 7) N/sq m). Although the mean fiber diameter and absolute force continued to decline through 3 wk of HU, P(sub 0) recovered to values not significantly different from control. The P(sub 0)/E(sub 0) ratio was significantly increased after 1 (5.5 +/- 0.3 to 7.1 +/- 0.6), 2, and 3 wk of HU, and the 2-wk (9.5 +/- 0.4) and 3-wk (9.4 +/- 0.8) values were significantly greater than the 1-wk values. The force-pCa and stiffness-pCa curves were shifted right- ward after 1, 2, and 3 wk of HU. At 1 wk of HU, the Ca(2+) sensitivity of isometric force, assessed by Ca(2+) concentration required for half-maximal force, was increased from the control value of 1.83 +/- 0.12 to 2.30 +/- 0.10 micrometers. In conclusion, after HU, the decrease in soleus fiber P(sub 0) can be explained by a reduction in the number of myofibrillar cross bridges per cross-sectional area. Our working hypothesis is that the loss of contractile protein reduces the number of cross bridges per cross-sectional area and increases the filament lattice spacing. The increased spacing reduces cross-bridge force and stiffness, but P(sub 0)/E(sub 0) increases because of a quantitatively greater effect on stiffness.

Calcium sensitivity of residual force enhancement in rabbit skinned fibers.

PubMed

Joumaa, V; Herzog, W

2014-08-15

Isometric force after active stretch of muscles is higher than the purely isometric force at the corresponding length. This property is termed residual force enhancement. Active force in skeletal muscle depends on calcium attachment characteristics to the regulatory proteins. Passive force has been shown to influence calcium attachment characteristics, specifically the sarcomere length dependence of calcium sensitivity. Since one of the mechanisms proposed to explain residual force enhancement is the increase in passive force that results from engagement of titin upon activation and stretch, our aim was to test if calcium sensitivity of residual force enhancement was different from that of its corresponding purely isometric contraction and if such a difference was related to the molecular spring titin. Force-pCa curves were established in rabbit psoas skinned fibers for reference and residual force-enhanced states at a sarcomere length of 3.0 μm 1) in a titin-intact condition, 2) after treatment with trypsin to partially eliminate titin, and 3) after treatment with trypsin and osmotic compression with dextran T-500 to decrease the lattice spacing in the absence of titin. The force-pCa curves of residual force enhancement were shifted to the left compared with their corresponding controls in titin-intact fibers, indicating increased calcium sensitivity. No difference in calcium sensitivity was observed between reference and residual force-enhanced contractions in trypsin-treated and osmotically compressed trypsin-treated fibers. Furthermore, calcium sensitivity after osmotic compression was lower than that observed for residual force enhancement in titin-intact skinned fibers. These results suggest that titin-based passive force regulates the increase in calcium sensitivity of residual force enhancement by a mechanism other than reduction of the myofilament lattice spacing. Copyright © 2014 the American Physiological Society.

A Reinvestigation of Transients in the Cyclopropane System by the Variable Encounter Method.

DTIC Science & Technology

1980-09-15

Code 260 Code AFRPL MKPA Arlingon, VA 22217 Edwards AFB, CA 93523 Attn: Mr. 0. Siegel Attn: Or. F. Roberto Office of Naval Research I AFSC Western Office...Office of Naval Research 2 Scientific Research Eastern Central Regional Directorate of Chemical & Office Atmospheric Sciences 495 Sumer Street Bolling ...I Directorate of Aero- San Francisco Area Office space Sciences One Hallidie Plaza Suite 601 Bolling Air Force Base San Francisco, CA 94102

17. Photographic copy of intial site plan for North Base: ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photographic copy of intial site plan for North Base: AF Job No. 1045, Military Construction: Muroc Bombing Range, Muroc Lake, California; Materiel Test Site: Location Plan, Sheet No. 1 of 11, May 1942. Records on file at AFFTC/CE-CECC-B (Design/Construction Flight/RPMC), Edwards AFB, California. - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

aerosol radiative effects and forcing: spatial and temporal distributions

NASA Astrophysics Data System (ADS)

Kinne, Stefan

2014-05-01

A monthly climatology for aerosol optical properties based on a synthesis from global modeling and observational data has been applied to illustrate spatial distributions and global averages of aerosol radiative impacts. With the help of a pre-industrial reference for aerosol optical properties from global modeling, also the aerosol direct forcing (ca -0.35W/m2 globally and annual averaged) and their spatial and seasonal distributions and contributions by individual aerosol components are estimated. Finally, CCN and IN concentrations associated with this climatology are applied to estimate aerosol indirect effects and forcing.

Credit PSR. Northeast and southwest facades of Sewage Pumping Station ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit PSR. Northeast and southwest facades of Sewage Pumping Station (Building 4330). Building retains its World War II construction materials and character. In the background at the extreme left is Building 4305 (Unicon Portable Hangar) - Edwards Air Force Base, North Base, Sewage Pumping Station, Southwest of E Street, Boron, Kern County, CA

1. NORTHWEST FRONT AND SOUTHWEST SIDE, SHOWING LOCATION OF BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. NORTHWEST FRONT AND SOUTHWEST SIDE, SHOWING LOCATION OF BUILDING 0520 WEST OF FIRING CONTOL BLOCK HOUSE (BLDG. 0545), BETWEEN SLED TRACK AND CAMERA ACCESS ROAD. - Edwards Air Force Base, South Base Sled Track, Observation Block House, Station "O" area, east end of Sled Track, Lancaster, Los Angeles County, CA

2. OBLIQUE VIEW OF WEST FRONT. The frames on an ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. OBLIQUE VIEW OF WEST FRONT. The frames on an angle originally held mirrors for viewing the tests from inside the building. Vertical frame originally held bullet glass. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

77 FR 55896 - Notice of Release Effecting Federal Grant Assurance Obligations Due to Airport Layout Plan...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... Grant Assurance Obligations Due to Airport Layout Plan Revision at Mather Airport, Sacramento, CA AGENCY... Mather Airport, Sacramento, California, which will provide for a release from the Grant Agreement... the closure of Mather Air Force Base pursuant to the Defense Base Closure and Realignment Act of 1988...

1. LOOKING SOUTH ALONG THE LONG AXIS FROM THE TOP ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. LOOKING SOUTH ALONG THE LONG AXIS FROM THE TOP OF THE LOADING RAMP. THE SOUTH ARM OF THE PIT IS COVERED BY A FEW INCHES OF WATER FROM RECENT RAINS. - Edwards Air Force Base, South Base, X-1 Loading Pit, Western Shore of Rogers Dry Lake, Boron, Kern County, CA

18. INTERIOR SURFACE OF THE SHORT SOUTH WALL OF AR9, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. INTERIOR SURFACE OF THE SHORT SOUTH WALL OF AR-9, WITH THE MORE RECENT CONCRETE BLOCK CONTROL ROOM AT THE LEFT AND ASSOCIATED CONCRETE PAVING IN THE FOREGROUND. - Edwards Air Force Base, South Base, Rammed Earth Aircraft Dispersal Revetments, Western Shore of Rogers Dry Lake, Boron, Kern County, CA

Space Shuttle Atlantis landing at 12:33 p.m. February 20 on the runway at Edwards Air Force Base, Ca

NASA Technical Reports Server (NTRS)

2001-01-01

Space Shuttle Atlantis landed at 12:33 p.m. February 20 on the runway at Edwards Air Force Base, California, where NASA's Dryden Flight Research Center is located. The mission, which began February 7, logged 5.3 million miles as the shuttle orbited earth while delivering the Destiny science laboratory to the International Space Station. Inclement weather conditions in Florida prompted the decision to land Atlantis at Edwards. The last time a space shuttle landed at Edwards was Oct. 24, 2000.

Velocity of sarcomere shortening in rat cardiac muscle: relationship to force, sarcomere length, calcium and time.

PubMed

Daniels, M; Noble, M I; ter Keurs, H E; Wohlfart, B

1984-10-01

The relation between force and velocity was determined in sixteen trabeculae of rat right ventricle as a function of time during a twitch, of sarcomere length and of external Ca2+ concentration, [Ca2+]o. The trabeculae were studied in modified Krebs-Henseleit solution at 25 degrees C. Force was measured with a semiconductor strain gauge. Sarcomere length was measured with a laser diffraction system. A servomotor system was used in which control could be switched between sarcomere length, muscle length and force. Force-velocity relations were derived from load clamps and from contractions in which sarcomere length was initially held constant followed by a quick release and slower release of the sarcomeres at controlled velocity. Force-velocity relations were fitted by Hill's equation (Hill, 1938), (Po-P) b = (P+a) V, where P = force, V = velocity, Po = isometric force in mN/mm2 and a and b are constants. For [Ca2+]o = 2.5 mM, with both interventions the values (mean +/- S.D.) were: b = 1.00 +/- 0.45 micron/s; a = 9.52 +/- 5.60 mN/mm2; Vo measured = 13.6 +/- 3.0 micron/s; Vo calculated = 13.4 +/- 3.4 micron/s; Po measured = 96.5 +/- 25.0 mN/mm2; Po calculated = 119.3 +/- 34.5 mN/mm2. Vo rose with [Ca2+]o to a maximum at [Ca2+]o = 1.2 mM when Po was about 50% of maximum, while Po rose with [Ca2+]o to a maximum at above 2.5 mM. Vo rose with time during the twitch to a maximum at 25 ms following onset of contraction; Po was then about 50% of the maximum that was obtained at 120 ms. Vo increased with sarcomere length from zero at a sarcomere length of 1.6 micron to a maximum at 1.85 micron. Between 1.85 micron and 2.3 micron, Vo was constant. At 1.85 micron, Po was about 60% of maximum Po. These results are compatible with the hypothesis that Vo is more sensitive than Po to the amount of Ca2+ bound to the contractile proteins, and that Vo reaches a maximal value with an amount of Ca2+ bound to the contractile proteins at which Po has obtained only about 50% of its maximal value.

Agonist-induced Ca2+ Sensitization in Smooth Muscle

PubMed Central

Artamonov, Mykhaylo V.; Momotani, Ko; Stevenson, Andra; Trentham, David R.; Derewenda, Urszula; Derewenda, Zygmunt S.; Read, Paul W.; Gutkind, J. Silvio; Somlyo, Avril V.

2013-01-01

Many agonists, acting through G-protein-coupled receptors and Gα subunits of the heterotrimeric G-proteins, induce contraction of smooth muscle through an increase of [Ca2+]i as well as activation of the RhoA/RhoA-activated kinase pathway that amplifies the contractile force, a phenomenon known as Ca2+ sensitization. Gα12/13 subunits are known to activate the regulator of G-protein signaling-like family of guanine nucleotide exchange factors (RhoGEFs), which includes PDZ-RhoGEF (PRG) and leukemia-associated RhoGEF (LARG). However, their contributions to Ca2+-sensitized force are not well understood. Using permeabilized blood vessels from PRG(−/−) mice and a new method to silence LARG in organ-cultured blood vessels, we show that both RhoGEFs are activated by the physiologically and pathophysiologically important thromboxane A2 and endothelin-1 receptors. The co-activation is the result of direct and independent activation of both RhoGEFs as well as their co-recruitment due to heterodimerization. The isolated recombinant C-terminal domain of PRG, which is responsible for heterodimerization with LARG, strongly inhibited Ca2+-sensitized force. We used photolysis of caged phenylephrine, caged guanosine 5′-O-(thiotriphosphate) (GTPγS) in solution, and caged GTPγS or caged GTP loaded on the RhoA·RhoGDI complex to show that the recruitment and activation of RhoGEFs is the cause of a significant time lag between the initial Ca2+ transient and phasic force components and the onset of Ca2+-sensitized force. PMID:24106280

Shear fluid-induced Ca2+ release and the role of mitochondria in rat cardiac myocytes.

PubMed

Belmonte, Steve; Morad, Martin

2008-03-01

Cardiac myocyte contraction occurs when Ca2+ influx through voltage-gated L-type Ca2+ channels causes Ca2+ release from ryanodine receptors of the sarcoplasmic reticulum (SR). Although mitochondria occupy about 35% of the cell volume in rat cardiac myocytes, and are thought to be located <300 nm from the junctional SR, their role in the beat-to-beat regulation of cardiac Ca2+ signaling remains unclear. We have recently shown that rapid ( approximately 20 ms) application of shear fluid forces ( approximately 25 dynes/cm2) to rat cardiac myocytes triggers slowly ( approximately 300 ms) developing Cai transients that were independent of activation of all transmembrane Ca2+ transporting pathways, but were suppressed by FCCP, CCCP, and Ru360, all of which are known to disrupt mitochondrial function. We have here used rapid 2-D confocal microscopy to monitor fluctuations in mitochondrial Ca2+ levels ([Ca2+]m) and mitochondrial membrane potential (Delta Psi m) in rat cardiac myocytes loaded either with rhod-2 AM or tetramethylrhodamine methyl ester (TMRM), respectively. Freshly isolated intact rat cardiac myocytes were plated on glass coverslips and incubated in 5 mM Ca2+ containing Tyrode's solution and 40 mM 2,3-butanedione monoxime (BDM) to inhibit cell contraction. Alternatively, myocytes were permeabilized with 10 microM digitonin and perfused with an "intracellular" solution containing 10 microM free [Ca2+], 5 mM EGTA, and 15 mM BDM. Direct [Ca2+]m measurements showed transient mitochondrial Ca2+ accumulation after exposure to 10 mM caffeine, as revealed by a 66% increase in the rhod-2 fluorescence intensity. Shear fluid forces, however, produced a 12% decrease in signal, suggesting that application of a mechanical force releases Ca2+ from the mitochondria. In addition, caffeine and CCCP or FCCP strongly reduced Delta Psi m, while application of a pressurized solution produced a transient Delta Psi m hyperpolarization in intact ventricular myocytes loaded with TMRM. The close proximity of mitochondria to ryanodine receptors and large [Ca2+] that develop in microdomains following calcium release are likely to play a critical role in regulating cytosolic Ca2+ signaling. We suggest that mitochondria may accumulate and release Ca2+ in response to mechanical forces generated by blood flow, independent of surface membrane-regulated CICR. The extent to which such a signaling mechanism contributes to stretch-induced increase in myocardial force and pathogenesis of arrhythmias remains to be assessed.

AERIAL VIEW OF THE MARTIN BOMBER PLANT LOOKING SOUTHEAST WITH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

AERIAL VIEW OF THE MARTIN BOMBER PLANT LOOKING SOUTHEAST WITH FORT CROOK AT THE RIGHT. Wing Historian's Office (WHO), ca. 1945 - Offutt Air Force Base, Glenn L. Martin-Nebraska Bomber Plant, Building D, Peacekeeper Drive, Bellevue, Sarpy County, NE

3. VIEW OF ESCAPE TUNNEL IN NORTH FACE OF LAUNCH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. VIEW OF ESCAPE TUNNEL IN NORTH FACE OF LAUNCH OPERATIONS BUILDING. BUNKER PERISCOPE VISIBLE ABOVE RIGHT CORNER OF TUNNEL. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

The NATO SOF Air Wing: A Basing Decision

DTIC Science & Technology

2012-12-01

AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943–5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING...NATO Special Operations Headquarters (NSHQ). NSHQ coordinates, trains, and employs NATO’s special operation forces. With the addition of organic SOF

129. INTERIOR OF RELAY BOX FOR HYDRAULIC CONTROL PANEL IN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

129. INTERIOR OF RELAY BOX FOR HYDRAULIC CONTROL PANEL IN UMBILICAL MAST PUMP ROOM (209), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

124. ACCUMULATORS AT LOWER RIGHT SIDE OF HYDRAULIC CONTROL PANEL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

124. ACCUMULATORS AT LOWER RIGHT SIDE OF HYDRAULIC CONTROL PANEL IN UMBILICAL MAST PUMP ROOM (209), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

21. DETAIL OF AIR HANDLER 1 (MST AIRCONDITIONING SYSTEM) INTERIOR, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. DETAIL OF AIR HANDLER 1 (MST AIR-CONDITIONING SYSTEM) INTERIOR, SOUTHEAST CORNER, STATION 30, SLC-3W MST - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

180. Photocopy of drawing (1965 mechanical drawing by Koebig & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

180. Photocopy of drawing (1965 mechanical drawing by Koebig & Koebig, Inc.) AIR CONDITIONING FOR THE MST, SHEET M-6 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

56. DETAIL OF PAYLOAD ELECTRICAL AND AIRCONDITIONING UMBILICAL CONNECTIONS ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

56. DETAIL OF PAYLOAD ELECTRICAL AND AIR-CONDITIONING UMBILICAL CONNECTIONS ON NORTH FACE OF SLC-3W UMBILICAL MAST - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

5. PERSONNEL ROOM ON WEST SIDE OF PYROTECHNIC SHED (BLDG. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. PERSONNEL ROOM ON WEST SIDE OF PYROTECHNIC SHED (BLDG. 757) STORAGE LOCKER ON EAST WALL; PADDED TABLE ON SOUTH WALL. - Vandenberg Air Force Base, Space Launch Complex 3, Pyrotechnic Shed, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

20. Photocopy of drawing (1961 mechanical drawing by Kaiser Engineers) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Photocopy of drawing (1961 mechanical drawing by Kaiser Engineers) ELECTRICAL LAYOUTS FOR VEHICLE SUPPORT BUILDING, SHEET E-2 - Vandenberg Air Force Base, Space Launch Complex 3, Vehicle Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

99. POWER DISTRIBUTION UNITS FOR BATTERIES AND RECTIFIERS, NORTHEAST SIDE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

99. POWER DISTRIBUTION UNITS FOR BATTERIES AND RECTIFIERS, NORTHEAST SIDE OF LANDLINE INSTRUMENTATION ROOM (106), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

106. INTERIOR OF CABLE TRAY TUNNEL, FROM LANDLINE INSTRUMENTATION ROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

106. INTERIOR OF CABLE TRAY TUNNEL, FROM LANDLINE INSTRUMENTATION ROOM (106), LSB (BLDG. 770), TOWARDS CABLE TRAY SHED - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

53. THRUST SECTION HEATER AND GASEOUS NITROGEN PURGE CONTROLS ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

53. THRUST SECTION HEATER AND GASEOUS NITROGEN PURGE CONTROLS ON EAST SIDE OF LAUNCH DECK. LAUNCHER IN BACKGROUND. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

141. NITROGEN SUPPLY PANEL PRESSURE REGULATOR IN NORTHWEST CORNER OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

141. NITROGEN SUPPLY PANEL PRESSURE REGULATOR IN NORTHWEST CORNER OF CONTROL ROOM (214), LSB (BLDG. 751), FACING WEST - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

79. VIEW FROM SOUTH OF NITROGEN AND HELIUM STORAGE TANKS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

79. VIEW FROM SOUTH OF NITROGEN AND HELIUM STORAGE TANKS AND CONTROL SKIDS ON SLC-3W FUEL APRON - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

100. INTERIOR OF SKID 9A: VENT VALVE AND RELIEF VALVE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

100. INTERIOR OF SKID 9A: VENT VALVE AND RELIEF VALVE FOR RAPID-LOAD LIQUID OXYGEN TANK - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

11. Credit BG. Interior of control and observation room at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Credit BG. Interior of control and observation room at Control and Recording Center, showing detail of switchboard and closed circuit television monitors. - Jet Propulsion Laboratory Edwards Facility, Control & Recording Center, Edwards Air Force Base, Boron, Kern County, CA

13. EQUIPMENT USED IN CLEAN ROOM (102), INCLUDING ROYCO PARTICLE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. EQUIPMENT USED IN CLEAN ROOM (102), INCLUDING ROYCO PARTICLE COUNTER (LEFT) AND STEREOSCOPE FOR MANUAL PARTICLE COUNTING (RIGHT) - Vandenberg Air Force Base, Space Launch Complex 3, Vehicle Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Interior detail, view to northnortheast showing support system for roof ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior detail, view to north-northeast showing support system for roof truss (typical), 90 mm lens plus electronic flash lighting. - Travis Air Force Base, Readiness Maintenance Hangar, W Street, Air Defense Command Readiness Area, Fairfield, Solano County, CA

X-48C Hybrid - Blended Wing Body Demonstrator

NASA Image and Video Library

2013-02-28

NASA X-48C Hybrid Wing Body aircraft flew over one of the runways laid out on Rogers Dry Lake at Edwards Air Force Base, CA, during a test flight from NASA's Dryden Flight Research Center on Feb. 28, 2013.

112. REFRIGERANT CONDENSER TANKS AND PRESSURE CONTROLS IN NORTHEAST CORNER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

112. REFRIGERANT CONDENSER TANKS AND PRESSURE CONTROLS IN NORTHEAST CORNER OF MECHANICAL EQUIPMENT ROOM (201), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

53. VIEW FROM FLOOR OF MAST TRENCH SHOWING BASE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

53. VIEW FROM FLOOR OF MAST TRENCH SHOWING BASE OF ERECT UMBILICAL MAST. AIR-CONDITIONING DUCTS VISIBLE ON RIGHT SIDE OF MAST. HYDRAULIC ACTUATOR ARMS FOR OPENING TRENCH DOORS VISIBLE ON LEFT SIDE OF PHOTO. 'DOOR STOP' PEDESTAL IN FOREGROUND. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

1. "X15 RUN UP AREA 230." A somewhat blurred, very ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. "X-15 RUN UP AREA 230." A somewhat blurred, very low altitude low oblique view to the northwest. This view predates construction of observation bunkers. Photo no. "14,696 58 A-AFFTC 17 NOV 58." - Edwards Air Force Base, X-15 Engine Test Complex, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

Credit PSR. View looks south southeast (160°) across top of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit PSR. View looks south southeast (160°) across top of Imhoff Tank. Bare earth directly beyond tank demarks sewage canal which conducted wastes to a sewage lagoon at the edge of Rogers Dry Lake. Main Base at Edwards AFB appears across the lakebed - Edwards Air Force Base, North Base, Imhoff Tank, Southwest of E Street, Boron, Kern County, CA

Functional responses of uremic single skeletal muscle fibers to redox imbalances.

PubMed

Mitrou, G I; Poulianiti, K P; Koutedakis, Y; Jamurtas, A Z; Maridaki, M D; Stefanidis, I; Sakkas, G K; Karatzaferi, C

2017-01-01

The exact causes of skeletal muscle weakness in chronic kidney disease (CKD) remain unknown with uremic toxicity and redox imbalances being implicated. To understand whether uremic muscle has acquired any sensitivity to acute redox changes we examined the effects of redox disturbances on force generation capacity. Permeabilized single psoas fibers (N =37) from surgically induced CKD (UREM) and sham-operated (CON) rabbits were exposed to an oxidizing (10 mM Hydrogen Peroxide, H 2 O 2 ) and/or a reducing [10 mM Dithiothreitol (DTT)] agent, in a blind design, in two sets of experiments examining: A) the acute effect of the addition of H 2 O 2 on maximal (pCa 4.4) isometric force of actively contracting fibers and the effect of incubation in DTT on subsequent re-activation and force recovery (N =9 CON; N =9 UREM fibers); B) the effect of incubation in H 2 O 2 on both submaximal (pCa 6.2) and maximal (pCa 4.4) calcium activated isometric force generation (N =9 CON; N =10 UREM fibers). Based on cross-sectional area (CSA) calculations, a 14 % atrophy in UREM fibers was revealed; thus forces were evaluated in absolute values and corrected for CSA (specific force) values. A) Addition of H 2 O 2 during activation did not significantly affect force generation in any group or the pool of fibers. Incubation in DTT did not affect the CON fibers but caused a 12 % maximal isometric force decrease in UREM fibers (both in absolute force p =0.024, and specific force, p =0.027). B) Incubation in H 2 O 2 during relaxation lowered subsequent maximal (but not submaximal) isometric forces in the Pool of fibers by 3.5 % (for absolute force p =0.033, for specific force p =0.019) but not in the fiber groups separately. Force generation capacity of CON and UREM fibers is affected by oxidation similarly. However, DTT significantly lowered force in UREM muscle fibers. This may indicate that at baseline UREM muscle could have already been at a more reduced redox state than physiological. This observation warrants further investigation as it could be linked to disease-induced effects. HIPPOKRATIA 2017, 21(1): 3-7.

5. "TEST STAND 13, CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. "TEST STAND 1-3, CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-06; no sheet number within title block. D.O. SERIES 1109/17, Rev. A. Stamped: AS BUILT; NO CHANGES. Date of Revision A: 11/1/50. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-3, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

7. "LAUNCH SILOS; SECTIONS, DETAILS." Specifications No. ENG043535973; Drawing No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. "LAUNCH SILOS; SECTIONS, DETAILS." Specifications No. ENG-04-353-59-73; Drawing No. 5841-S-4; D.O. SERIES AW1525/26 Rev. A.; Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract No. 6601, Rev. A., Date 11 Sep 59. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

6. "LAUNCH SILOS, PLAN AND DETAILS." Specifications No. OC15973; Drawing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. "LAUNCH SILOS, PLAN AND DETAILS." Specifications No. OC1-59-73; Drawing No. 5841 S-3; D.O. SERIES AW-1525/25 Rev. A.; Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract No. 6601, Rev. A., Date 11 Sep 59. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Missile Silo Type, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

Wastewater Characterization Survey, Vandenberg, AFB, CA.

DTIC Science & Technology

1991-03-01

ENVIRONMENTAL HEALTH DIRECTORATE L Brooks Air Force Base, Texas 78235-5000 A B 0 Mrch 1991 RFinal Technical Report for Period 25 September 1990 - 5 October...recommendation for use by the United States Air Force. The Public Affairs Office has reviewed this report , and it is releasable to the National Technical...Information Service, where it will be available to the general public, including foreign nations. This report has been reviewed and is approved for

Demonstration of Laser-Induced Fluorescence on Krypton Hall Effect Thruster

DTIC Science & Technology

2011-08-10

5b. GRANT NUMBER Thruster 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) William A. Hargus Jr., Gregory X. Azarnia, and Michael R. Nakles 5d. PROJECT... William A. Hargus, Jr. a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified SAR 13 19b. TELEPHONE NUMBER (include...Thruster William A. Hargus, Jr.∗ Gregory M. Azarnia† Michael R. Nakles‡ Air Force Research Laboratory, Edwards Air Force Base, CA 93524 There is growing

6. "EXPERIMENTAL ROCKET ENGINE TEST STATION AT AFFTC." A low ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. "EXPERIMENTAL ROCKET ENGINE TEST STATION AT AFFTC." A low oblique aerial view of Test Area 1-115, looking south, showing Test Stand 1-3 at left, Instrumentation and Control building 8668 at center, and Test Stand 15 at right. The test area is under construction; no evidence of railroad line in photo. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

23. "A CAPTIVE ATLAS MISSILE EXPLODED DURING THE TEST ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. "A CAPTIVE ATLAS MISSILE EXPLODED DURING THE TEST ON TEST STAND 1-A, 27 MARCH 1959, PUTTING THAT TEST STAND OUT-OF-COMMISSION. STAND WAS NOT REPAIRED FOR THE ATLAS PROGRAM BUT TRANSFERRED TO ROCKETDYNE AND MODIFIED FOR THE F-l ENGINE PROGRAM." - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

2. TEST AREA 1115, A VIEW TO THE SOUTHEAST FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. TEST AREA 1-115, A VIEW TO THE SOUTHEAST FROM THE DECK OF TEST STAND 1-5. AT RIGHT IS BUILDING 8642, MACHINE SHOP FOR TEST STAND 1-5. AT LEFT IS BUILDING 8649, AND PART OF BUILDING 8647, TEST STAND 1-4, IS VISIBLE TO LEFT OF BLDG. 8649. (PANORAMA 1/2). - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

7. "AERIAL VIEW OF THE TEST AREA, DIRECTORATE OF MISSILE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. "AERIAL VIEW OF THE TEST AREA, DIRECTORATE OF MISSILE CAPTIVE TEST, EDWARDS AFB. 8 AUG 57." In upper left corner, photo no. "8462 57" cropped out: "A-AFFTC 8 AUG 57, RETL TEST AREA" This photo is a high oblique view, showing the wing of the photo plane and Test Area 1-115. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

12. "TEST STAND; STRUCTURAL; DEFLECTOR PIT DETAILS, SHEET NO. 1." ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. "TEST STAND; STRUCTURAL; DEFLECTOR PIT DETAILS, SHEET NO. 1." Specifications No. ENG-04-353-55-72; Drawing No. 60-09-12; sheet 41 of 148; file no. 1320/92, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

11. "INSTRUMENTATION AND CONTROL SYSTEMS, EQUIPMENT LOCATION, TEST STAND TERMINAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. "INSTRUMENTATION AND CONTROL SYSTEMS, EQUIPMENT LOCATION, TEST STAND TERMINAL ROOM, PLANS AND SECTION." Specifications No. ENG-04-353-55-72; Drawing No. 60-0912; sheet 106 of 148; file no. 1321/57. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

27. "TEST STAND; STRUCTURAL; SIDEWALL, NORTH WALL AND SOUTH WALL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. "TEST STAND; STRUCTURAL; SIDEWALL, NORTH WALL AND SOUTH WALL FRAMING ELEVATIONS." Specifications No. ENG-04353-55-72; Drawing No. 60-09-12; sheet 27 of 148; file no. 1320/78. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, Rev. B; date: 15 April 1957. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

9. "TEST STAND; STRUCTURAL; CABLE TUNNEL, PLAN, SECTIONS, DETAILS." Specifications ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. "TEST STAND; STRUCTURAL; CABLE TUNNEL, PLAN, SECTIONS, DETAILS." Specifications No. OC1-55-72-(Rev.); Drawing No. 60-09-12; sheet 43 of 148; file no. AF 1320/94, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

Instrumentation and control systems, equipment location; instrumentation and control building, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Instrumentation and control systems, equipment location; instrumentation and control building, instrumentation room, bays and console plan. Specifications No. Eng-04-353-55-72; drawing no. 60-09-12; sheet 110 of 148; file no. 1321/61. Stamped: Record drawing - as constructed. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

7. "CONTROL BUILDING; FLOOR PLAN, ELEVATIONS AND DETAILS." Specifications No. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. "CONTROL BUILDING; FLOOR PLAN, ELEVATIONS AND DETAILS." Specifications No. OC1-59-53; Drawing No. 5841-A-1; D.O. SERIES AW1525/2 Rev. B. Stamped: RECORD DRAWING AS CONSTRUCTED. Below stamp: Contract No. 5619, Rev. B. Date: 7-8-59. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Firing Control Building, Test Area 1-100, northeast end of Test Area 1-100 Road, Boron, Kern County, CA

Credit PSR. This view looks northeast (54°) at the open ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit PSR. This view looks northeast (54°) at the open burn unit as it is seen on approach from Circle Drive. The metal shed in front of the earth mound personnel shield contained controls for a stove that was formerly used to burn scrap propellants in the adjacent pit (see HAER photo CA163-V-1). Regulations changed to permit open pit burning of such materials - Jet Propulsion Laboratory Edwards Facility, Incinerator, Edwards Air Force Base, Boron, Kern County, CA

81. THREE ADDITIONAL BLACK AND WHITE VIDEO MONITORS LOCATED IMMEDIATELY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

81. THREE ADDITIONAL BLACK AND WHITE VIDEO MONITORS LOCATED IMMEDIATELY WEST OF THOSE IN CA-133-1-A-80. COMPLEX SAFETY WARNING LIGHTS FOR SLC-3E (PAD 2) AND BLDG. 763 (LOB) LOCATED ABOVE MONITOR 3; GREEN LIGHTS ON BOTTOM OF EACH STACK ILLUMINATED. LEFT TO RIGHT BELOW MONITORS: ACCIDENT REPORTING EMERGENCY NOTIFICATION SYSTEM TELEPHONE, ATLAS H FUEL COUNTER, AND DIGITAL COUNTDOWN CLOCK. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

A Recommended Scale for Cognitive Screening in Clinical Trials of Parkinson’s Disease

PubMed Central

Chou, Kelvin L.; Amick, Melissa M.; Brandt, Jason; Camicioli, Richard; Frei, Karen; Gitelman, Darren; Goldman, Jennifer; Growdon, John; Hurtig, Howard I.; Levin, Bonnie; Litvan, Irene; Marsh, Laura; Simuni, Tanya; Tröster, Alexander I.; Uc, Ergun Y.

2010-01-01

Background Cognitive impairment is common in Parkinson’s disease (PD). There is a critical need for a brief, standard cognitive screening measure for use in PD trials whose primary focus is not on cognition. Methods The Parkinson Study Group (PSG) Cognitive/Psychiatric Working Group formed a Task Force to make recommendations for a cognitive scale that could screen for dementia and mild cognitive impairment in clinical trials of PD where cognition is not the primary outcome. This Task Force conducted a systematic literature search for cognitive assessments previously used in a PD population. Scales were then evaluated for their appropriateness to screen for cognitive deficits in clinical trials, including brief administration time (<15 minutes), assessment of the major cognitive domains, and potential to detect subtle cognitive impairment in PD. Results Five scales of global cognition met the predetermined screening criteria and were considered for review. Based on the Task Force’s evaluation criteria the Montreal Cognitive Assessment (MoCA), appeared to be the most suitable measure. Conclusions This Task Force recommends consideration of the MoCA as a minimum cognitive screening measure in clinical trials of PD where cognitive performance is not the primary outcome measure. The MoCA still requires further study of its diagnostic utility in PD populations but appears to be the most appropriate measure among the currently available brief cognitive assessments. Widespread adoption of a single instrument such as the MoCA in clinical trials can improve comparability between research studies on PD. PMID:20878991

Laser scanning confocal microscopy and laser tweezers based experiments to understand dentine-bacteria interactions

NASA Astrophysics Data System (ADS)

Peng, Sum Chee; Mohanty, Samarendra; Gupta, P. K.; Kishen, Anil

2007-02-01

Failure of endodontic treatment is commonly due to Enterococcal infection. In this study influence of chemical treatments of type-I collagen membrane by chemical agents commonly used in endodontic treatment on Enterococcus faecalis cell adherence was evaluated. In order to determine the change in number of adhering bacteria after chemical treatment, confocal laser scanning microscopy was used. For this, overnight culture of E faecalis in All Culture broth was applied to chemically treated type-I collagen membrane. It was found that Ca(OH) II treated groups had statistically significant (p value=0.05) increase in population of bacteria adherence. The change in adhesion force between bacteria and collagen was determined by using optical tweezers (1064 nm). For this experiment, Type-I collagen membrane was soaked for 5 mins in a media that contained 50% all culture media and 50% saturated Ca(OH) II . The membrane was spread on the coverslip, on which diluted bacterial suspension was added. The force of laser tweezers on the bacteria was estimated at different trap power levels using viscous drag method and trapping stiffness was calculated using Equipartition theorem method. Presence of Ca(OH) II was found to increase the cell-substrate adherence force from 0.38pN to >2.1pN. Together, these experiments show that it was highly probable that the increase in adherence to collagen was due to a stronger adhesion in the presence of Ca (OH) II.

North Base hangars as seen from the edge of Rogers ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

North Base hangars as seen from the edge of Rogers Dry Lake, looking north northwest (338°). The security fence surrounding the hangars and aircraft apron appears in the foreground. From left to right appear Building 4305 (Unicon Portable Hangar), Building 4401 (Hangar No. 1), Building 4400 (warehouse), Building 4402 (Hangar No. 2) and Building 4505. - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

18. Photographic copy of site plan for additions to North ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photographic copy of site plan for additions to North Base: Job No. Muroc A(511), Military Construction, Third District Region, San Bernardino, California; Muroc Bombing Range, Muroc Lake, Calif; Additional Temporary Construction, Materiel Center Flight Test Base, Location Plan, February 1943. Reproduced from the holdings of the National Archives, Pacific Southwest Region - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

5. PHOTOCOPY OF DRAWING (1975 ELECTRICAL DRAWING BY THE STRATEGIC ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. PHOTOCOPY OF DRAWING (1975 ELECTRICAL DRAWING BY THE STRATEGIC AIR COMMAND, USAF) ELECTRICAL PLANS FOR BUILDING 768, SHEET 7 OF 8 - Vandenberg Air Force Base, Space Launch Complex 3, Entry Control Point, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

21. STATION 70.5 OF MST, WEST SIDE. AIRCONDITIONING DUCT AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. STATION 70.5 OF MST, WEST SIDE. AIR-CONDITIONING DUCT AT TOP; POWER BOX ON RIGHT; WINCH ON LEFT. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

18. Photocopy of drawing (1961 architectural drawing by Kaiser Engineers) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photocopy of drawing (1961 architectural drawing by Kaiser Engineers) FLOOR PLAN, ELEVATIONS, AND SCHEDULE FOR VEHICLE SUPPORT BUILDING, SHEET A-1 - Vandenberg Air Force Base, Space Launch Complex 3, Vehicle Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

19. Photocopy of drawing (1961 piping drawing by Kaiser Engineers) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photocopy of drawing (1961 piping drawing by Kaiser Engineers) PIPING PLANS AND DETAILS FOR VEHICLE SUPPORT BUILDING, SHEET P-1 - Vandenberg Air Force Base, Space Launch Complex 3, Vehicle Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

35. DETAIL OF STRETCH SLING CYLINDER AND PULLEY LOCATED ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. DETAIL OF STRETCH SLING CYLINDER AND PULLEY LOCATED ON EAST SIDE OF SLC-3W MST STATION 85.5 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Case Study: Lackland Air Force Base Commissary

EPA Pesticide Factsheets

DeCA chose to adopt a NH3/CO2 cascade system for two main reasons: (1) to control future capital and operating costs, and (2) to meet the energy and sustainability goals the U.S. Government has established for all public buildings.

4. VIEW OF NORTH FACE OF MST. NOTE: ENVIRONMENTAL DOOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW OF NORTH FACE OF MST. NOTE: ENVIRONMENTAL DOOR ON THE LOWER EAST SIDE OF THE NORTH FACE IS MISSING. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

154. Photocopy of drawing (1963 structural drawing by General Dynamics/Astronautics) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

154. Photocopy of drawing (1963 structural drawing by General Dynamics/Astronautics) STRUCTURAL PLANS FOR MST STATION 30, SHEET S84 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

225. Photocopy of drawing (1967 structural drawing by General Dynamics/Astronautics) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

225. Photocopy of drawing (1967 structural drawing by General Dynamics/Astronautics) WIND DEFLECTOR FOR THE UMBILICAL MAST, SHEET S122 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

158. Photocopy of drawing (1963 structural drawing by General Dynamics/Astronautics) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

158. Photocopy of drawing (1963 structural drawing by General Dynamics/Astronautics) FRAMING PLANS FOR MST STATION 124, SHEET S94 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

183. Photocopy of drawing (1965 mechanical drawing by Koebig & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

183. Photocopy of drawing (1965 mechanical drawing by Koebig & Koebig, Inc.) GASEOUS NITROGEN PURGE SYSTEM FOR THE MST, SHEET M-2 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

22. DOOR CONTROL BOX AT STATION 70.5 OF MST FOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. DOOR CONTROL BOX AT STATION 70.5 OF MST FOR CONTROL OF SOUTH DOORS. NITROGEN PRESSURE REGULATOR ON LEFT. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

72. NORTHEAST SIDE OF NITROGEN EXCHANGERS IN FOREGROUND; FUEL APRON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

72. NORTHEAST SIDE OF NITROGEN EXCHANGERS IN FOREGROUND; FUEL APRON IN BACKGROUND. NORTHEAST CORNER OF WEST CAMERA TOWER ALSO IN BACKGROUND. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

68. GENERAL VIEW OF SOUTH AND EAST SIDES OF SLC3W ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

68. GENERAL VIEW OF SOUTH AND EAST SIDES OF SLC-3W LIQUID OXYGEN APRON. CABLE TRAYS IN FOREGROUND - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

75. GENERAL VIEW OF PORTABLE PAYLOAD AIRCONDITIONING SYSTEM LOCATED ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

75. GENERAL VIEW OF PORTABLE PAYLOAD AIR-CONDITIONING SYSTEM LOCATED ON NORTH SIDE OF SLC-3W LIQUID OXYGEN APRON - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Computer Maintenance Operations Center (CMOC), additional computer support equipment ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Computer Maintenance Operations Center (CMOC), additional computer support equipment - Beale Air Force Base, Perimeter Acquisition Vehicle Entry Phased-Array Warning System, Techinical Equipment Building, End of Spencer Paul Road, north of Warren Shingle Road (14th Street), Marysville, Yuba County, CA

102. VIEW OF GRANETZ 'EVENTRECORDER' COMPUTER AND GENERAL ELECTRIC PRINTERS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

102. VIEW OF GRANETZ 'EVENT-RECORDER' COMPUTER AND GENERAL ELECTRIC PRINTERS FOR GRANETZ OUTPUT LOCATED NEAR EAST WALL OF LANDLINE INSTRUMENTATION ROOM - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

22. DETAIL OF CHILLERS 1 AND 2 (MST AIRCONDITIONING SYSTEM) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. DETAIL OF CHILLERS 1 AND 2 (MST AIR-CONDITIONING SYSTEM) INTERIOR, NORTHEAST CORNER, STATION 30, SLC-3W MST - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

1. VIEW OF SEWAGE TREATMENT PLANT (BLDG. 769) SOUTH OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF SEWAGE TREATMENT PLANT (BLDG. 769) SOUTH OF STORAGE SHED (BLDG 773). SECURITY FENCE EAST OF SEWAGE TREATMENT PLANT. - Vandenberg Air Force Base, Space Launch Complex 3, Sewage Treatment Plant, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Wiring repair area, southwest corner of room 227, looking east. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Wiring repair area, southwest corner of room 227, looking east. Repair area includes soldering equipment and wire dispensing reels hanging from the ceiling - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

Improved Pyrolysis Micro reactor Design via Computational Fluid Dynamics Simulations

DTIC Science & Technology

2017-05-23

Dynamics Simulations Ghanshyam L. Vaghjiani Air Force Research Laboratory (AFMC) AFRL/RQRS 1 Ara Drive Edwards AFB, CA 93524-7013 Air Force...Aerospace Systems Directorate Air Force Research Laboratory AFRL/RQRS 1 Ara Road Edwards AFB, CA 93524 *Email: ghanshyam.vaghjiani@us.af.mil IMPROVED...PYROLYSIS MICRO-REACTOR DESIGN VIA COMPUTATIONAL FLUID DYNAMICS SIMULATIONS Ghanshyam L. Vaghjiani* DISTRIBUTION A: Approved for public release

Enhancement of Force Generated by Individual Myosin Heads in Skinned Rabbit Psoas Muscle Fibers at Low Ionic Strength

PubMed Central

Sugi, Haruo; Abe, Takahiro; Kobayashi, Takakazu; Chaen, Shigeru; Ohnuki, Yoshiki; Saeki, Yasutake; Sugiura, Seiryo

2013-01-01

Although evidence has been presented that, at low ionic strength, myosin heads in relaxed skeletal muscle fibers form linkages with actin filaments, the effect of low ionic strength on contraction characteristics of Ca2+-activated muscle fibers has not yet been studied in detail. To give information about the mechanism of muscle contraction, we have examined the effect of low ionic strength on the mechanical properties and the contraction characteristics of skinned rabbit psoas muscle fibers in both relaxed and maximally Ca2+-activated states. By progressively decreasing KCl concentration from 125 mM to 0 mM (corresponding to a decrease in ionic strength μ from 170 mM to 50 mM), relaxed fibers showed changes in mechanical response to sinusoidal length changes and ramp stretches, which are consistent with the idea of actin-myosin linkage formation at low ionic strength. In maximally Ca2+-activated fibers, on the other hand, the maximum isometric force increased about twofold by reducing KCl concentration from 125 to 0 mM. Unexpectedly, determination of the force-velocity curves indicated that, the maximum unloaded shortening velocity Vmax, remained unchanged at low ionic strength. This finding indicates that the actin-myosin linkages, which has been detected in relaxed fibers at low ionic strength, are broken quickly on Ca2+ activation, so that the linkages in relaxed fibers no longer provide any internal resistance against fiber shortening. The force-velocity curves, obtained at various levels of steady Ca2+-activated isometric force, were found to be identical if they are normalized with respect to the maximum isometric force. The MgATPase activity of muscle fibers during isometric force generation was found not to change appreciably at low ionic strength despite the two-fold increase in Ca2+-activated isometric force. These results can be explained in terms of enhancement of force generated by individual myosin heads, but not by any changes in kinetic properties of cyclic actin-myosin interaction. PMID:23691080

Credit PSR. View looking north northeast (12°) across surface remains ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit PSR. View looking north northeast (12°) across surface remains of North Base swimming pool. The southeast edge of the pool appearing in the foreground may seem to be a sidewalk to the casual observer; the wavy inside edge of this walk matches the pool side visible in historic construction photos (See HAER photo CA-170-Q-2). The telephone pole in the midground of the view is inside the pool proper. Building 4312 (Liquid Oxygen Repair Facility) appears in left background, Building 4456 (Fire House No. 4) in middle background, and Building 4444 (Communications Building) in right background - Edwards Air Force Base, North Base, Swimming Pool, Second Street, Boron, Kern County, CA

Interpolated twitches in fatiguing single mouse muscle fibres: implications for the assessment of central fatigue

PubMed Central

Place, Nicolas; Yamada, Takashi; Bruton, Joseph D; Westerblad, Håkan

2008-01-01

An electrically evoked twitch during a maximal voluntary contraction (twitch interpolation) is frequently used to assess central fatigue. In this study we used intact single muscle fibres to determine if intramuscular mechanisms could affect the force increase with the twitch interpolation technique. Intact single fibres from flexor digitorum brevis of NMRI mice were dissected and mounted in a chamber equipped with a force transducer. Free myoplasmic [Ca2+] ([Ca2+]i) was measured with the fluorescent Ca2+ indicator indo-1. Seven fibres were fatigued with repeated 70 Hz tetani until 40% initial force with an interpolated pulse evoked every fifth tetanus. Results showed that the force generated by the interpolated twitch increased throughout fatigue, being 9 ± 1% of tetanic force at the start and 19 ± 1% at the end (P < 0.001). This was not due to a larger increase in [Ca2+]i induced by the interpolated twitch during fatigue but rather to the fact that the force–[Ca2+]i relationship is sigmoidal and fibres entered a steeper part of the relationship during fatigue. In another set of experiments, we observed that repeated tetani evoked at 150 Hz resulted in more rapid fatigue development than at 70 Hz and there was a decrease in force (‘sag’) during contractions, which was not observed at 70 Hz. In conclusion, the extent of central fatigue is difficult to assess and it may be overestimated when using the twitch interpolation technique. PMID:18403421

7. Credit PSR. Detail view looks east at Building 4306 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Credit PSR. Detail view looks east at Building 4306 (Boiler House) and at the south facade of Building 4305. Ground disturbance in foreground was a pit lined with plastic film for placement of a temporary fuel tank. - Edwards Air Force Base, North Base, Unicon Portable Hangar, First & C Streets, Boron, Kern County, CA

Effects of rapid shortening on rate of force regeneration and myoplasmic [Ca2+] in intact frog skeletal muscle fibres

PubMed Central

Vandenboom, R; Claflin, D R; Julian, F J

1998-01-01

The effect of rapid shortening on rate of force regeneration (dF/dtR) was examined in single, intact frog (Rana temporaria) skeletal muscle fibres (3·0 °C). Step releases leading to unloaded shortening were applied after 500 ms of stimulation, during the plateau of an isometric tetanus. Initial mean sarcomere length ranged from 2·05 to 2·35 μm; force regeneration after shortening was at 2·00 μm.Values for dF/dtR following a 25 nm half-sarcomere−1 release were 3·17 ± 0·17 (mean ± s.e.m., n= 8) times greater than the initial rate of rise of force before release (dF/dtI). As release size was increased from 25 to 175 nm half-sarcomere−1, the relationship between release size and dF/dtR decreased sharply before attaining a plateau value that was 1·34 ± 0·09 times greater than dF/dtI. Despite wide variations in dF/dtR, the velocity of unloaded shortening remained constant (2·92 ± 0·08 μm half-sarcomere−1 s−1; n= 8) for the different release amplitudes used in this study.To investigate its role in the attenuation of dF/dtR with increased shortening, the effects of rapid ramp (constant velocity) shortening on intracellular free Ca2+ concentration ([Ca2+]i) were monitored using the Ca2+-sensitive fluorescent dye furaptra. Compared with an isometric contraction, rapid fibre shortening was associated with a transient increase in [Ca2+]i while force regeneration after shortening was associated with a transient reduction in [Ca2+]i. The greatest reductions in [Ca2+]i were associated with the largest amplitude ramps.Cross-bridge-mediated modifications of the Ca2+ affinity of troponin C (TnC) may explain the fluctuations in [Ca2+]i observed during and after ramps. Associated fluctuations in TnC Ca2+ occupancy could play a role in the reduction of dF/dtR with increasing release size. PMID:9679172

An ultra-sensitive impedimetric immunosensor for detection of the serum oncomarker CA-125 in ovarian cancer patients

NASA Astrophysics Data System (ADS)

Johari-Ahar, M.; Rashidi, M. R.; Barar, J.; Aghaie, M.; Mohammadnejad, D.; Ramazani, A.; Karami, P.; Coukos, G.; Omidi, Y.

2015-02-01

Effective treatment of ovarian cancer depends upon the early detection of the malignancy. Here, we report on the development of a new nanostructured immunosensor for early detection of cancer antigen 125 (CA-125). A gold electrode was modified with mercaptopropionic acid (MPA), and then consecutively conjugated with silica coated gold nanoparticles (AuNP@SiO2), CdSe quantum dots (QDs) and anti-CA-125 monoclonal antibody (mAb). The engineered MPA|AuNP@SiO2|QD|mAb immunosensor was characterised using transmission electron microscopy (TEM), atomic force microscopy (AFM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Successive conjugation of AuNP@SiO2, CdSe QD and anti-CA-125 mAb onto the gold electrode resulted in sensitive detection of CA-125 with a limit of detection (LOD) of 0.0016 U mL-1 and a linear detection range (LDR) of 0-0.1 U mL-1. Based on the high sensitivity and specificity of the immunosensor, we propose this highly stable and reproducible biosensor for the early detection of CA-125.Effective treatment of ovarian cancer depends upon the early detection of the malignancy. Here, we report on the development of a new nanostructured immunosensor for early detection of cancer antigen 125 (CA-125). A gold electrode was modified with mercaptopropionic acid (MPA), and then consecutively conjugated with silica coated gold nanoparticles (AuNP@SiO2), CdSe quantum dots (QDs) and anti-CA-125 monoclonal antibody (mAb). The engineered MPA|AuNP@SiO2|QD|mAb immunosensor was characterised using transmission electron microscopy (TEM), atomic force microscopy (AFM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Successive conjugation of AuNP@SiO2, CdSe QD and anti-CA-125 mAb onto the gold electrode resulted in sensitive detection of CA-125 with a limit of detection (LOD) of 0.0016 U mL-1 and a linear detection range (LDR) of 0-0.1 U mL-1. Based on the high sensitivity and specificity of the immunosensor, we propose this highly stable and reproducible biosensor for the early detection of CA-125. Electronic supplementary information (ESI) available: Additional materials including Figures and discussion as described in the text. See DOI: 10.1039/c4nr06687a

Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle.

PubMed

Watanabe, Daiki; Kanzaki, Keita; Kuratani, Mai; Matsunaga, Satoshi; Yanaka, Noriyuki; Wada, Masanobu

2015-06-01

The aim of this study was to examine whether prolonged low-frequency force depression (PLFFD) that occurs in situ is the result of decreased myofibrillar Ca(2+) sensitivity and/or reduced sarcoplasmic reticulum (SR) Ca(2+) release. Intact rat gastrocnemius muscles were electrically stimulated via the sciatic nerve until force was reduced to ~50% of the initial and dissected 30 min following the cessation of stimulation. Skinned fibre and whole muscle analyses were performed in the superficial region composed exclusively of type IIB fibres. Fatiguing stimulation significantly reduced the ratio of force at low frequency to that at high frequency to 65% in skinned fibres (1 vs. 50 Hz) and 73% in whole muscles (20 vs. 100 Hz). In order to evaluate changes in myofibrillar Ca(2+) sensitivity and ryanodine receptor caffeine sensitivity, skinned fibres were activated in Ca(2+)- and caffeine-containing solutions, respectively. Skinned fibres from fatigued muscles displayed decreased caffeine sensitivity together with increased myofibrillar Ca(2+) sensitivity. Treatment with 2,2'-dithiodipyridine and reduced glutathione induced a smaller increase in myofibrillar Ca(2+)sensitivity in fatigued than in rested fibres. In fatigued muscles, S-glutathionylation of troponin I was increased and submaximal SR Ca(2+) release, induced by 4-chloro-m-cresol, was decreased. These findings suggest that in the early stage of PLFFD that occurs in fast-twitch muscles of exercising animals and humans, S-glutathionylation of troponin I may attenuate PLFFD by increasing myofibrillar Ca(2+) sensitivity and that under such a circumstance, PLFFD may be ascribable to failure of SR Ca(2+) release.

View looks east northeast (64°) along North Base Road, showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View looks east northeast (64°) along North Base Road, showing North Base as it appears on approach by automobile. From left to right, one sees Building 4505 with its ancillary buildings; Building 4500, Control Tower; followed by Buildings 4402 (Hangar No. 2), 4401 (Hangar No. 1), and 4305 (Unicon Portable Hangar) with their respective ancillary structures. - Edwards Air Force Base, North Base, North Base Road, Boron, Kern County, CA

A novel mechanism for the Ca(2+)-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase

PubMed Central

1994-01-01

Mechanisms of Ca2+ sensitization of both myosin light chain (MLC) phosphorylation and force development by protein kinase C (PKC) were studied in permeabilized tonic smooth muscle obtained from the rabbit femoral artery. For comparison, the Ca2+ sensitizing effect of guanosine 5'-O-(gamma-thiotriphosphate) (GTP gamma S) was examined, which had been previously shown to inhibit MLC phosphatase in phasic vascular smooth muscle. We now report that PKC activators (phorbol esters, short chain synthetic diacylglycerols and a diacylglycerol kinase inhibitor) and GTP gamma S significantly increase both MLC phosphorylation and force development at constant [Ca2+]. Major phosphorylation site occurring in the presence of phorbol-12,13- dibutyrate (PDBu) or GTP gamma S at constant [Ca2+] is the same serine residue (Ser-19) as that phosphorylated by MLC kinase in response to increased Ca2+ concentrations. In an ATP- and Ca(2+)-free solution containing 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4- diazepine (ML-9), to avoid the kinase activity, both PDBu and GTP gamma S significantly decreased the rate of MLC dephosphorylation to half its control value. However, PDBu inhibited the relaxation rate more than did GTP gamma S. In the presence of microcystin-LR to inhibit the phosphatase activity, neither PDBu nor GTP gamma S affected MLC phosphorylation and force development. These results indicate that PKC, like activation of GTP binding protein, increases Ca2+ sensitivity of both MLC phosphorylation and force production through inhibition of MLC phosphatase. PMID:7807049

Resolving the molecular mechanism of cadherin catch bond formation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manibog, Kristine; Li, Hui; Rakshit, Sabyasachi

2014-06-02

Classical cadherin Ca(2+)-dependent cell-cell adhesion proteins play key roles in embryogenesis and in maintaining tissue integrity. Cadherins mediate robust adhesion by binding in multiple conformations. One of these adhesive states, called an X-dimer, forms catch bonds that strengthen and become longer lived in the presence of mechanical force. Here we use single-molecule force-clamp spectroscopy with an atomic force microscope along with molecular dynamics and steered molecular dynamics simulations to resolve the molecular mechanisms underlying catch bond formation and the role of Ca(2+) ions in this process. Our data suggest that tensile force bends the cadherin extracellular region such that theymore » form long-lived, force-induced hydrogen bonds that lock X-dimers into tighter contact. When Ca(2+) concentration is decreased, fewer de novo hydrogen bonds are formed and catch bond formation is eliminated« less

5. Credit BG. View looking northeast at southwest facade of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Credit BG. View looking northeast at southwest facade of Building 4505 as seen from top of Building 4500 (Control Tower). A warehouse wing adjoins southeast side of hangar at right. In far right background is Building 4511, Jet Fuel Depot for grade JP-5 fuel. - Edwards Air Force Base, North Base, Hangar, End of North Base Road, Boron, Kern County, CA

2. X15 RUN UP AREA (Jan 59). A sharp, higher ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. X-15 RUN UP AREA (Jan 59). A sharp, higher altitide low oblique aerial view to the north, showing runway, at far left; X-15 Engine Test Complex in the center. This view predates construction of observation bunkers. - Edwards Air Force Base, X-15 Engine Test Complex, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

7. COMPLETE X15 VEHICLE TEST STAND AFTER AN ENGINE FIRE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. COMPLETE X-15 VEHICLE TEST STAND AFTER AN ENGINE FIRE OR EXPLOSION. Wreckage of engine is still fixed in its clamp; X-15 vehicle lies on the ground detached from engine. - Edwards Air Force Base, X-15 Engine Test Complex, Rocket Engine & Complete X-15 Vehicle Test Stands, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

1. Credit PSR. View looks north northeast (18°) down typical ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Credit PSR. View looks north northeast (18°) down typical dust ditch paralleling First Street. Building 4401 (Hangar No. 1) appears at the extreme right of the view. Building 4456 (Fire House No. 4), Building 4444 (Communications Building), and Building 4505 appear in the background. - Edwards Air Force Base, North Base, Dust Ditch System, Traversing North Base, Boron, Kern County, CA

8. PHOTOCOPY OF DRAWING (1975 ELECTRICAL DRAWING BY THE RALPH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. PHOTOCOPY OF DRAWING (1975 ELECTRICAL DRAWING BY THE RALPH M. PARSONS COMPANY) ELECTRICAL PLAN AND DETAILS FOR BUILDING 762-A, SHEET E4 - Vandenberg Air Force Base, Space Launch Complex 3, Technical Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA