Closing the Convoy Security Gap

DTIC Science & Technology

2013-04-11

January 18, 2013. Heiser Jr., LtGen Joseph M. Vietnam Studies: Logistic Support. Washington, DC: Department of the Army, 1991. Killbane, Richard E...School Library, 1968. http://www.transchool.eustis.army.mil/lic/documents/pdf/bellino.pdf 13 LtGen Joseph M. Heiser Jr., Vietnam Studies: Logistic

Femme Fatale: An Examination of the Role of Women in Combat and the Policy Implications for Future American Military Operations (Drew Paper Number 5, August 2009)

DTIC Science & Technology

2009-08-01

subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE...NUMBER OF PAGES 137 19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Air University Allen G. Peck, Lt Gen, Commander Air Force Research Institute John A . Shaud, Gen, PhD

The Influence of Islam in the Military; Comparative Study of Malaysia, Indonesia and Pakistan

DTIC Science & Technology

2004-03-01

3(1) of the Federal constitution since independence.90 However, it never practiced ‘shariah’ law because the first Prime Minister, Tunku Abdul ......the military to be professional and modern. Musharraf also brought in his men to head the military with Lt Gen Muhammad Aziz Khan and Lt Gen

KENNEDY SPACE CENTER, FLA. - The news media capture the words and images of the Return To Flight Task Group (RTFTG) which held its first public meeting at the Debus Center, KSC Visitor Complex. The group is co-chaired by former Shuttle commander Richard O. Covey and retired Air Force Lt. Gen. Thomas P. Stafford, who was an Apollo commander. The RTFTG was at KSC to conduct organizational activities, tour Space Shuttle facilities and receive briefings on Shuttle-related topics. The task group was chartered by NASA Administrator Sean O’Keefe to perform an independent assessment of NASA’s implementation of the final recommendations of the Columbia Accident Investigation Board.

NASA Image and Video Library

2003-08-07

KENNEDY SPACE CENTER, FLA. - The news media capture the words and images of the Return To Flight Task Group (RTFTG) which held its first public meeting at the Debus Center, KSC Visitor Complex. The group is co-chaired by former Shuttle commander Richard O. Covey and retired Air Force Lt. Gen. Thomas P. Stafford, who was an Apollo commander. The RTFTG was at KSC to conduct organizational activities, tour Space Shuttle facilities and receive briefings on Shuttle-related topics. The task group was chartered by NASA Administrator Sean O’Keefe to perform an independent assessment of NASA’s implementation of the final recommendations of the Columbia Accident Investigation Board.

Naval Aviation Costs: Targeting Operations and Support

DTIC Science & Technology

2013-12-01

Brian Jacobs n Cmdr. Craig Owen Aubrey Dennis n Michael Berkin n Roy Lancaster n Tim Simpson n Duane Mallicoat Farmer, AIR-6.0B, is the...Department. Jacobs , AIR-6.7B, is the military director, Logistics and Maintenance Planning Department. Owen is the COMFRC Produc- tion director. Dennis...Board Extended Members Vice Adm. McCoy , NAVSEA Vice Adm. Van Buskirk, CNP Lt. Gen. Ronling, MARFORPAC Lt. Gen. Paxton, MARFORCOM

Joint Force Quarterly. Issue 67, 4th Quarter, October 2012

DTIC Science & Technology

2012-10-01

a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 2012 2...Defense Douglas N. Hime Naval War College Mark H. Jacobsen Marine Corps Command and Staff College Daniel T. Kuehl Information Resources Management...Norris Air Command and Staff College Col Mark Pizzo, USMC (Ret.) National War College James A . Schear Office of the Secretary of Defense LtGen Bernard

KENNEDY SPACE CENTER, FLA. - The Return To Flight Task Group (RTFTG) holds the first public meeting at the Debus Center, KSC Visitor Complex. Members and staff at the table, from left, are retired Navy Rear Adm. Walter H. Cantrell, David Raspet, retired Air Force Col. Gary S. Geyer, Dr. Kathryn Clark, Dr. Decatur B. Rogers, Dr. Dan L. Crippen, Dr. Walter Broadnax and astronaut Carlos Noriega. The RTFTG was at KSC to conduct organizational activities, tour Space Shuttle facilities and receive briefings on Shuttle-related topics. The task group was chartered by NASA Administrator Sean O’Keefe to perform an independent assessment of NASA’s implementation of the final recommendations of the Columbia Accident Investigation Board. The group is co-chaired by former Shuttle commander Richard O. Covey and retired Air Force Lt. Gen. Thomas P. Stafford, who was an Apollo commander.

NASA Image and Video Library

2003-08-07

KENNEDY SPACE CENTER, FLA. - The Return To Flight Task Group (RTFTG) holds the first public meeting at the Debus Center, KSC Visitor Complex. Members and staff at the table, from left, are retired Navy Rear Adm. Walter H. Cantrell, David Raspet, retired Air Force Col. Gary S. Geyer, Dr. Kathryn Clark, Dr. Decatur B. Rogers, Dr. Dan L. Crippen, Dr. Walter Broadnax and astronaut Carlos Noriega. The RTFTG was at KSC to conduct organizational activities, tour Space Shuttle facilities and receive briefings on Shuttle-related topics. The task group was chartered by NASA Administrator Sean O’Keefe to perform an independent assessment of NASA’s implementation of the final recommendations of the Columbia Accident Investigation Board. The group is co-chaired by former Shuttle commander Richard O. Covey and retired Air Force Lt. Gen. Thomas P. Stafford, who was an Apollo commander.

The United States Air Force and the Culture of Innovation, 1945-1965

DTIC Science & Technology

2002-01-01

US Dept of Transportation; typically they hover between 85 and 95 percent. 16. Kent C. Redmond and Thomas M. Smith, Project Whirlwind: A Case Histo...Washing- ton, D.C.: AF Hist and Museums Prog, 1994). 14. Thomas A . Sturm, The USAF SAB: Its First Twenty Years 1944–1964 (Washington, D.C.: USAF...allegations at Ramo-Wooldridge and the Air Force’s approach. Schriever answered them in a letter to Lt. Gen. Thomas Power, the commander of ARDC, in

Deliberate Force. A Case Study in Effective Air Campaigning

DTIC Science & Technology

2000-01-01

two events that had to occur before air strikes could begin. One of the warring factions had to pull one of the so-called triggers, and NATO and...mortaring on 28 August served to pull the required trigger. Admiral Smith turned the NATO key immedi- ately, and Lt Gen Rupert Smith—commander of...manned aerial vehicles confirmed Admiral Smith’s suspicions that the Serbs were not pulling back, he told Janvier that "there’s no intent being

Band of Brothers or Dysfunctional Family? A Military Perspective on Coalition Challenges During Stability Operations

DTIC Science & Technology

2011-01-01

vehicle LCT landing craft, tank LO liaison officer LOO line of operation MIS Military Intelligence Service MND (SE) Multi-National Division South East...23, 2000. Their units then fell under the command of the peace- keeping force (PKF) commander, Lt Gen Jaime de los Santos of the Philippines, who was...rather than instantaneous transition of responsibility between his command and the PKF. He suggested to General de los Santos that the UNTAET staff

First Apollo 11 sample return containers arrive at Ellington AFB

NASA Technical Reports Server (NTRS)

1969-01-01

The first Apollo 11 sample return container, containing lunar surface material, arrives at Ellington Air Force Base by air from the Pacific recovery area. Happily posing for photographs with the rock box are (left to right) George M. Low, Manager, Apollo Spacecraft Program, Manned Spacecraft Center (MSC); U.S. Air Force Lt. Gen. Samuel C. Phillips, Apollo Program Director, Office of Manned Space Flight, NASA HQ.; George S. Trimble, MSC Deputy Director (almost obscured); Eugene G. Edmonds, MSC Photographic Technology Laboratory; RIchard S. Johnston (in back), Special Assistant to the MSC Director; Dr. Thomas O. Paine, NASA Administrator; and Dr. Robert R. Gilruth, MSC Director.

Vice President Pence lands at Redstone Army Airfield

NASA Image and Video Library

2017-09-25

Air Force Two lands with Vice President Mike Pence along with Congressman Robert Aderholt at the Redstone Army Airfield in Huntsville, Alabama, on Monday, Sept. 25. They were greeted by NASA’s Marshall Space Flight Center Director Todd May and Redstone Arsenal’s Lt. Gen. Edward Daly. The Vice President is visiting NASA’s Marshall Center to meet with employees, view test hardware for NASA’s Space Launch System — America’s new deep-space rocket, and tour the Payload Operations Integration Center, “science central” for the International Space Station.

West Europe Report

DTIC Science & Technology

1985-07-15

Lisbon TAL & QUAL in Portuguese 17 May 85 p 3 [Text] Manuel da Costa Bras, Lt Col in the reserves and High Commissioner against Corruption, is facing...people around Gen Eanes, starting with Lt Col Melo Antunes. The PRD itself has already announced many times that it would not oppose such an

Record of Operations Against Soviet Russia on Northern and Western Fronts of Manchuria, and in Northern Korea (August 1945)

DTIC Science & Technology

1954-09-01

Col Masao Segawa Col Kaoru Okano Col Shigeru Imada - Maj Akizo Yokoyama Capt Toyonobu Kondo Maj Toru Mi tano - Lt Col Sen Nagai - 1st Lt Ichiro...nchurians, and its commander, 1st Lieutenant Ishikawa , was killed. The only unit of the division to engage in action--the 5th Company of the 24lst...Lieutenant: 161 Irie, Major: 43 Ishikawa , 1st Lt: 160 Itung River: 15, 37, 42-43 Iwai, Lt Gen, Torajiro (Cmdr lOath Div): 143, 147-48, 154 Japanese

Army Sustainment. Volume 47, Issue 5, September-October 2015

DTIC Science & Technology

2016-02-29

stu- dents with the opportunity to work directly with noncommissioned officers and warrant officers as part of their training. By Maj. Brian J ...Need to Expand Training and Education on Nonstandard Logistics Capt. Christopher J . Sheehan 12 Multinational Logistics Interoperability Capt...Theresa D. Christie DEPARTMENTS “ “ Ex Off icio Brig. Gen. Kurt J . Ryan Chief of Ordnance Brig. Gen. Ronald Kirklin The Quartermaster General Lt. Gen

View of Mission Control Center during Apollo 13 splashdown

NASA Technical Reports Server (NTRS)

1970-01-01

Dr. Thomas O. Paine (center), NASA Administrator, and other NASA Officials joined others in applauding the successful splashdown of the Apollo 13 crewmen. Others among the large crowd in the Mission Operations Control Room of the Mission Control Center, Manned Spacecraft Center (MSC) at the time of recovery were U.S. Air Force Lt. Gen. Samuel C. Phillips (extreme left), who formerly served as Apollo program Director, Office of Manned Space Flight, NASA Headquarters; Dr. Charles A. Berry (third from left), Director, Medical Research and Operations Directorate, MSC; and Dr. George M. Low, Associate NASA Administrator.

JPRS Report, Soviet Union, Military Affairs.

DTIC Science & Technology

1988-05-03

JPRS-UMA-88-008 1 ö U ü / b 3 MAY 1988 !■■■■■ «■■■If FOREIGN BROADCAST INFORMATION SERVICE JP/? S Report— Soviet Union Military Affairs...Appro-rod for pab&e miaä^T REPRODUCED BY U S . DEPARTMENTOFCOMMERCE i NATIONAL TECHNICAL INFORMATIONSERVICE SPRINGFIELD, VA 22161 (Q...Agencies [Lt Gen Justice S . Maksimov; Moscow KRASNAYA ZVEZDA, 4 Dec 87] 13 Col Gen Babyev on Afghan Veterans’ Benefits [Col Gen VBabyev; Moscow

The Quest for Relevant Air Power: Continental European Responses to the Air Power Challenges of the Post-Cold War Era

DTIC Science & Technology

2011-08-01

Air Power Centre]), Col (GS) Thomas Lorber, FüAk (Führungsakademie); Lt Col Dr. Wolfgang Schmidt, Military- Historical Research Office, Potsdam; Lt Gen...Col (GS) Dr. Michael Wolfgang Romba, Col (GS) Hans-Dieter Schön and his staff, Col (GS) Lothar Schmidt, and Lt Col (GS) Michael Trautermann. In the...Multinational Air Wing (DMAW) Project,” accessed 2 March 2007, http://www.euroairgroup.org/act_DMAW.htm. 75. Wolfgang Lange, “Lufttransport—Ansätze

Air Force Follow-On Review. Protecting The Force: Lessons From Fort Hood

DTIC Science & Technology

2010-01-01

Executive Summary body markings, assessing the potential for violence, clarifying firearms policies, and pro- moting consistent application of policies...Mr. Byron Cotton Lt Col Christopher Alonzo Lt Col Cheryl Scaglione Lt Col Sonya Collins Lt Col Kristine Blackwell Lt Col Christopher Oleksa Lt Col

Army Network-Enabled Operations: Expectations, Performance, and Opportunities for Future Improvements

DTIC Science & Technology

2012-01-01

trusted the ability of the Army networks to alert him to the presence of significant ground threats. Similarly, then–MG James Mattis was confident that he...CJTF and Component Essential Capability Analysis, draft briefing, August 2, 2004. Mattis , LtGen. James N., U.S. Marine Corps, and LtCol. (Ret...Hattie Bouyer in Headquarters, Depart- ment of the Army, Office of the Chief Information Officer/G-6. We are indebted to James Cooke and Colonel Chris

After Desert Storm. The U.S. Army and the Reconstruction of Kuwait

DTIC Science & Technology

1999-01-01

Kuwaiti people . I am grateful to vi Marilyn Hunter for her skilled editing and unflagging enthusiasm for this project. At the Center of Military History...the Joint Staff, Lt . Gen. Michael P C . Carns, to arrange a briefing on civil affairs capabilities for the Kuwaitis . Lt . Col. Dennis C . Barlow ...from the Psychological Operations/Civil Affairs Branch of the Directorate for Current Operations (J-33) of the Joint Staff delivered the briefing the

Roles for National Guard Components: Current Thoughts and Future Possibilities

DTIC Science & Technology

2000-04-01

Gen Russell C. Davis, chief, National Guard Bureau, remarks at the National Chamber of Commerce , Washington, D.C., June 1999. 5 Moskos and Burk, 176...Lt Gen Russell C. Davis, chief, National Guard Bureau, remarks at the National Chamber of Commerce , Washington, D.C., June 9 1999. 5 National Guard...National Guard Bureau, remarks to the National Chamber of Commerce , Washington, D.C., June 1999, n.p. On-line. Internet, 27 February 2000, available at

United States Forces Korea > Home

Science.gov Websites

commander; Gen. Leem Ho Young, Combined Forces Command deputy commander; and Gen. Lee Sun-jin, Gen. Lee, Sun Forces Command deputy commander; and Gen. Lee Sun-jin, Gen. Lee, Sun-Jin, Chairman of the Republic of deputy commander; and Gen. Lee Sun-jin, Gen. Lee, Sun-Jin, Chairman of the Republic of Korea Joint Chiefs

House Hearing

NASA Image and Video Library

2012-03-28

Retired astronaut Lt. Gen. Thomas Stafford testifies during a hearing before the House Committee on Science, Space, and Technology regarding access to and sustainability of the International Space Station, Wednesday, March 28, 2012 at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Carla Cioffi)

Muscle synergies may improve optimization prediction of knee contact forces during walking.

PubMed

Walter, Jonathan P; Kinney, Allison L; Banks, Scott A; D'Lima, Darryl D; Besier, Thor F; Lloyd, David G; Fregly, Benjamin J

2014-02-01

The ability to predict patient-specific joint contact and muscle forces accurately could improve the treatment of walking-related disorders. Muscle synergy analysis, which decomposes a large number of muscle electromyographic (EMG) signals into a small number of synergy control signals, could reduce the dimensionality and thus redundancy of the muscle and contact force prediction process. This study investigated whether use of subject-specific synergy controls can improve optimization prediction of knee contact forces during walking. To generate the predictions, we performed mixed dynamic muscle force optimizations (i.e., inverse skeletal dynamics with forward muscle activation and contraction dynamics) using data collected from a subject implanted with a force-measuring knee replacement. Twelve optimization problems (three cases with four subcases each) that minimized the sum of squares of muscle excitations were formulated to investigate how synergy controls affect knee contact force predictions. The three cases were: (1) Calibrate+Match where muscle model parameter values were calibrated and experimental knee contact forces were simultaneously matched, (2) Precalibrate+Predict where experimental knee contact forces were predicted using precalibrated muscle model parameters values from the first case, and (3) Calibrate+Predict where muscle model parameter values were calibrated and experimental knee contact forces were simultaneously predicted, all while matching inverse dynamic loads at the hip, knee, and ankle. The four subcases used either 44 independent controls or five synergy controls with and without EMG shape tracking. For the Calibrate+Match case, all four subcases closely reproduced the measured medial and lateral knee contact forces (R2 ≥ 0.94, root-mean-square (RMS) error < 66 N), indicating sufficient model fidelity for contact force prediction. For the Precalibrate+Predict and Calibrate+Predict cases, synergy controls yielded better contact force predictions (0.61 < R2 < 0.90, 83 N < RMS error < 161 N) than did independent controls (-0.15 < R2 < 0.79, 124 N < RMS error < 343 N) for corresponding subcases. For independent controls, contact force predictions improved when precalibrated model parameter values or EMG shape tracking was used. For synergy controls, contact force predictions were relatively insensitive to how model parameter values were calibrated, while EMG shape tracking made lateral (but not medial) contact force predictions worse. For the subject and optimization cost function analyzed in this study, use of subject-specific synergy controls improved the accuracy of knee contact force predictions, especially for lateral contact force when EMG shape tracking was omitted, and reduced prediction sensitivity to uncertainties in muscle model parameter values.

MISSION CONTROL CENTER (MCC) VIEW - CONCLUSION APOLLO 11 CELEBRATION - MSC

NASA Image and Video Library

1969-07-24

S69-40024 (24 July 1969) --- NASA and Manned Spacecraft Center (MSC) officials join in with the flight controllers, in the Mission Operations Control Room (MOCR) in the Mission Control Center (MCC), in celebrating the successful conclusion of the Apollo 11 lunar landing mission. Identifiable in the picture, starting in foreground, are Dr. Robert R. Gilruth, MSC Director; George M. Low, Manager, Apollo Spacecraft Program, MSC; Dr. Christopher C. Kraft Jr., MSC Director of Flight Operation; U.S. Air Force Lt. Gen. Samuel C. Phillips (with glasses, looking downward), Apollo Program Director, Office of Manned Space Flight, NASA Headquarters; and Dr. George E. Mueller (with glasses, looking toward left), Associate Administrator, Office of Manned Space Flight, NASA Headquarters. Former astronaut John H. Glenn Jr. is standing behind Mr. Low.

Methods of Hydrographic Surveying Used by Different Countries.

DTIC Science & Technology

1983-03-01

902 Greece 16. Training and Education Division Hellenic Navy General Staff GENIKO EPITELIO NAYTIKOY (GEN) Greece 17. Hellenic Naval Academy SHOLI...Maratos Hellenic Navy Hydrographic Service Athens BST 902 Greece 21. Hellenic Army Geographic Service V. GENIKO EPITELIO STRATOU Athens, Greece 22. LT

Independent Review of the Defense Logistics Agencys Roles and Missions

DTIC Science & Technology

2014-12-01

3,000 3,500 C-5 F-15 C-130 KC-135 B-1 B-52 E-3 N IIN / N SN s BoM Items Ordered BoM Items Not Ordered Orders Not on BoM Warner- Robbins ALC Tinker... Tony Poleo Fred Pribble Michael Scott BG Steven Shapiro Brig Gen Giovanni Tuck Col Rex Adee Linda Barnett Matthew Beebe CDR Tim Benesh COL...DeVincentis Lt Gen (Ret) Kathleen Gainey RADM (Ret) Mark Heinrich CAPT (Ret) Stuart Jones Eric Peltz Marc Robbins This page is intentionally blank

A comparative analysis of physiological responses at submaximal workloads during different laboratory simulations of field cycling.

PubMed

Kenny, G P; Reardon, F D; Marion, A; Thoden, J S

1995-01-01

The purpose of this study was to evaluate the relationships between heart rate (fc), oxygen consumption (VO2), peak force and average force developed at the crank in response to submaximal exercise employing a racing bicycle which was attached to an ergometer (RE), ridden on a treadmill (TC) and ridden on a 400-m track (FC). Eight male trained competitive cyclists rode at three pre-determined work intensities set at a proportion of their maximal oxygen consumption (VO2max): (1) below lactate threshold [work load that produces a VO2 which is 10% less than the lactate threshold VO2 (sub-LT)], (2) lactate threshold VO2 (LT), and (3) above lactate threshold [workload that produces a VO2 which is 10% greater than lactate threshold VO2 (supra-LT)], and equated across exercise modes on the basis of fc. Voltage signals from the crank arm were recorded as FM signals for subsequent representation of peak and average force. Open circuit VO2 measurements were done in the field by Douglas bag gas collection and in the laboratory by automated gas collection and analysis. fc was recorded with a telemeter (Polar Electro Sport Tester, PE3000). Significant differences (P < 0.05) were observed: (1) in VO2 between FC and both laboratory conditions at sub-LT intensity and LT intensities, (2) in peak force between FC and TC at sub-LT intensity, (3) in average force between FC and RE at sub-LT. No significant differences were demonstrated at supra-LT intensity for VO2. Similarly no significant differences were observed in peak and average force for either LT or supra-LT intensities. These data indicate that equating work intensities on the basis of fc measured in laboratory conditions would overestimate the VO2 which would be generated in the field and conversely, that using fc measured in the laboratory to establish field work intensity would underestimate mechanical workload experienced in the field.

Human Spaceflight Safety Hearing

NASA Image and Video Library

2009-12-02

U.S. Rep. Gabrielle Giffords, D-Ariz., left, speaks with reitred astronaut Lt. Gen. Thomas Stafford prior to the start of a hearing before the House Subcommitte on Space and Aeronautics regarding Safety of Human Spaceflight on Capitol Hill, Wednesday, Dec. 2, 2009, in Washington. Photo Credit: (NASA/Bill Ingalls)

Coming Soon: More Cyber Careers?

Science.gov Websites

exploring the possibility of creating a cyber career field for Army civilians," Lt. Gen. Edward C Programs and Posture," April 14. Establishing a cyber career management field for civilians may be working to implement a cyber career management field for enlisted personnel that will encompass accessions

Defense Intelligence Agency

Science.gov Websites

Military Power Publications Photo Gallery Speeches and Testimonies DIA Director's 2018 Reading List No FEAR Home DIA Director's 2018 Reading List DIA Director's 2018 Reading List Just released! DIA Director Army Lt. Gen. Robert Ashley's 2018 Professional Reading List Read More DIA Director gives Worldwide Threat

Newsroom

Science.gov Websites

from Air Force Gen. Lori Robinson during a ceremony held at Peterson Air Force Base today. May 24, 2018 Gen. O'Shaughnessy assumes command of NORAD, USNORTHCOM Peterson Air Force Base, Colo. - Air Force Gen terminal Sept. 22, 2017 at Joint Base San Antonio-Kelly Field. The cargo was being staged at the Federal

Severnsia strombeulima n. gen. & sp. from Hawaii (Mollusca, Gastropoda: Caenogastropoda: Eulimidae).

PubMed

Geiger, Daniel L

2016-02-29

The malacofauna of Hawaii is rather well-known, owing to Kay (1979) and Severns (2011). Both works stand out because they include a large number of the generally under-represented micromollusks (<5 mm). Here a striking new genus and species of a microsnail is reported from that region.

$36 Million Command and Control Facility at Camp Leatherneck, Afghanistan: Unwanted, Unneeded, and Unused

DTIC Science & Technology

2015-05-01

Memorandum of Major Danisha L. Morris , JA, Chief, Contract and Fiscal Law (June 29, 2010). SIGAR-15-57-SP Report: $36 Million Command and Control...Facility at Camp Leatherneck, Afghanistan Page 60 EXHIBIT 10 -----Original Message----- From: Mills LtGen Richard P Sent: Tuesday , February 11

House Hearing

NASA Image and Video Library

2012-03-28

Retired astronaut Lt. Gen. Thomas Stafford, right, and Cristina Chaplain, director, Acquisition and Sourcing Management, U.S. Government Accountability Office listen during a hearing before the House Committee on Science, Space, and Technology regarding access to and sustainability of the International Space Station, Wednesday, March 28, 2012 at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Carla Cioffi)

Joint Maneuver Test Range on Eglin Air Force Base, Florida Final Environmental Assessment

DTIC Science & Technology

2009-12-14

Common Name Status State Federal Fish Acipenser oxyrinchus desotoi Gulf Sturgeon LS LT Awaous banana River Goby - - Etheostoma okaloosae Okaloosa...westianus Gulfcoast Lupine LT - Macranthera flammea Hummingbird Flower LE - Magnolia ashei Ashe’s Magnolia LE - Magnolia pyramidata Pyramidal Magnolia LE...Stemmed Panic Grass LT - Pinguicula lutea Yellow Butterwort LT - Pinguicula planifolia Swamp Butterwort LT - Pinguicula primuliflora Primrose- Flowered

’When You Get a Job to Do, Do It.’ The Airpower Leadership of Lt Gen William H. Tunner

DTIC Science & Technology

2008-01-01

controls; oxygen system; painting of placards and insignia ; rigging and surface controls Station No. 5 Instruments; automatic pilot; electrical system...misinform the Germans and con- vince them that they alone had saved the city from Nazi control.4 While these actions focused on establishing a dominant

Marine Corps Reserve Officer Manpower Modifications During the Long War: A Case to Achieve Parity with the Active Component

DTIC Science & Technology

2008-01-01

Marine Corps University, Quantico, VA, 2007. Kiszely, Lt-Gen Sir John, "Learning about Counterinsurgency" Military Review Mar-Apr 2007, 10-11. Miles ...Matthew B., A. Michael Huberman . Qualitative Data Analysis: An Expanded Sourcebook. 2nd ed. SAGE Publications, Inc, Thousands Oaks, CA, 1994. 31

Transformation of Polish Air Forces: What Is Required to Meet NATO Obligations

DTIC Science & Technology

2002-04-01

Graduation Requirements Advisor: Lt Col Marshell G. Cobb, Ph.D. Maxwell Air Force Base, Alabama April 2002 Report Documentation Page Form ApprovedOMB No...like to gratefully acknowledge the assistance of my Faculty Research Advisor, Lt Col Marshell G. Cobb, during this project. The inputs, advice, and

KSC-86PC-0310

NASA Image and Video Library

1986-10-09

CAPE CANAVERAL, Fla. - Kennedy Space Center Director Lt. Gen. Forrest S. McCartney, far right, stands in front of the space shuttle Atlantis the morning after it is rolled out to Launch Pad 39B. Standing with McCartney is, from right to left, Bob Sieck, director of Shuttle Management and Operations, Bill Warren, pad site manager, and Gene Thomas, director of Launch and Landing Operations. Photo credit: NASA

Memetics--A Growth Industry in US Military Operations

DTIC Science & Technology

2006-01-01

Ret) and Schmitt John F., presentation to MCCDC, September, 2005. 2 Dawkins , R. (1976), “The Selfish Gene ,” Oxford University Press, Oxford 1...NY: Atlantic Monthly Press; 1995. Brodie, Richard, “Virus of the Mind: The New Science of the Meme” Dawkins , R. (1976), “The Selfish Gene ...interpersonal and societal interaction. Richard Dawkins introduced 1 Van Riper, Paul K., LtGen USMC

China Naval Modernization: Implications for U.S. Navy Capabilities - Background and Issues for Congress

DTIC Science & Technology

2014-02-28

established method for countering an opponent’s military capability. A September 30, 2011, press report, for example, quotes Lieutenant General Herbert ...to address it. We are unable to provide additional details.”... 122 Spencer Ackerman, “How To Kill...China Naval Modernization: Implications for U.S. Navy Capabilities Congressional Research Service 105 As early as Feb. 17 [2011], Lt. Gen. Herbert

The Year of Transition in Review

DTIC Science & Technology

2007-01-01

quarter that 114 border forts have been constructed thus far, and 5 points of entry have been completed.315 SIGIR’s ground project surveys ...security services.366 Lt. Gen. Dempsey recently estimated that 20-25% of the National Police “needed to be weeded out.”367 Finally, recent surveys ...sector development Transportation and Communications system, 33 site surveys have been completed for the communication towers between Mosul and

Force majeure: Will climate change affect our ability to attain Good Environmental Status for marine biodiversity?

PubMed

Elliott, Michael; Borja, Ángel; McQuatters-Gollop, Abigail; Mazik, Krysia; Birchenough, Silvana; Andersen, Jesper H; Painting, Suzanne; Peck, Myron

2015-06-15

The EU Marine Strategy Framework Directive (MSFD) requires that Good Environmental Status (GEnS), is achieved for European seas by 2020. These may deviate from GEnS, its 11 Descriptors, targets and baselines, due to endogenic managed pressures (from activities within an area) and externally due to exogenic unmanaged pressures (e.g. climate change). Conceptual models detail the likely or perceived changes expected on marine biodiversity and GEnS Descriptors in the light of climate change. We emphasise that marine management has to accommodate 'shifting baselines' caused by climate change particularly during GEnS monitoring, assessment and management and 'unbounded boundaries' given the migration and dispersal of highly-mobile species. We suggest climate change may prevent GEnS being met, but Member States may rebut legal challenges by claiming that this is outside its control, force majeure or due to 'natural causes' (Article 14 of the MSFD). The analysis is relevant to management of other global seas. Copyright © 2015 Elsevier Ltd. All rights reserved.

Vice President Pence Tours Jet Propulsion Laboratory

NASA Image and Video Library

2018-04-28

U.S. Vice President Mike Pence, left, thanks JPL Deputy Director Lt. Gen. (Ret) Larry James, JPL Director Michael Watkins, JPL Distinguished Visiting Scientist and Spouse of UAG Chairman James Ellis, Elisabeth Pate-Cornell , UAG Chairman, Admiral (Ret) James Ellis , and California Institute of Technology President Thomas Rosenbaum, right, for giving him a tour of NASA's Jet Propulsion Laboratory, Saturday, April 28, 2018 in Pasadena, California. Photo Credit: (NASA/Bill Ingalls)

China Naval Modernization: Implications for U.S. Navy Capabilities-Background and Issues for Congress

DTIC Science & Technology

2014-02-28

method for countering an opponent’s military capability. A September 30, 2011, press report, for example, quotes Lieutenant General Herbert Carlisle...address it. We are unable to provide additional details.”... 122 Spencer Ackerman, “How To Kill...Lt. Gen. Herbert J. Carlisle, the Air Force’s deputy chief of staff for operations, plans, and requirements, had said a public document explaining

Intelligence in the Internet Era

DTIC Science & Technology

2003-01-01

and the enhanced exploitation capabili ties that information technology and the Internet give our adver saries. NSA�s Director, Lt. Gen. Michael Hayden...From Semaphore to Predator Intelligence in the Internet Era A. Denis Clift Actionable information from around the globe is today the air we breathe... Technology / Internet era: �What it all boils down to is that faster, smaller, cheaper elec tro-optical digital technologies have put into our hands enor

JPRS Report, East Asia, Southeast Asia.

DTIC Science & Technology

1988-10-24

Governor 6 Brig General Warsito, West Nusa Tenggara Governor 7 Lt General H. Ismail, Central Java Governor 7 Brig Gen H. Ramli Hasan Basri, South...included one ex-commander of a Sereikan company . In the first 9 months of this year, the provin- cial administration received 627 misled people...fishing boats are part of a cooperative effort with Minasanega Pertiwi, Inc., an Indonesian company , to catch fish within EEZ waters, and, what is

20 Years of Success: Science, Technology, and the Nuclear Weapons Stockpile

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

On Oct. 22, 2015, NNSA celebrated the proven success of the Stockpile Stewardship Program at a half-day public event featuring remarks by Secretary of Energy Ernest Moniz, Secretary of State John Kerry, and Under Secretary for Nuclear Security and NNSA Administrator Lt. Gen. (retired) Frank G. Klotz. The event also featured remarks by Deputy Secretary of Energy Elizabeth Sherwood-Randall and NNSA Principal Deputy Administrator Madelyn Creedon.

High-Force Versus Low-Force Lumbar Traction in Acute Lumbar Sciatica Due to Disc Herniation: A Preliminary Randomized Trial.

PubMed

Isner-Horobeti, Marie-Eve; Dufour, Stéphane Pascal; Schaeffer, Michael; Sauleau, Erik; Vautravers, Philippe; Lecocq, Jehan; Dupeyron, Arnaud

This study compared the effects of high-force versus low-force lumbar traction in the treatment of acute lumbar sciatica secondary to disc herniation. A randomized double blind trial was performed, and 17 subjects with acute lumbar sciatica secondary to disc herniation were assigned to high-force traction at 50% body weight (BW; LT50, n = 8) or low force traction at 10% BW (LT10, n = 9) for 10 sessions in 2 weeks. Radicular pain (visual analogue scale [VAS]), lumbo-pelvic-hip complex motion (finger-to-toe test), lumbar-spine mobility (Schöber-Macrae test), nerve root compression (straight-leg-raising test), disability (EIFEL score), drug consumption, and overall evaluation of each patient were measured at days 0, 7, 1, 4, and 28. Significant (P < .05) improvements were observed in the LT50 and LT10 groups, respectively, between day 0 and day 14 (end of treatment) for VAS (-44% and -36%), EIFEL score (-43% and -28%) and overall patient evaluation (+3.1 and +2.0 points). At that time, LT50 specifically improved in the finger-to-toe test (-42%), the straight-leg-raising test (+58), and drug consumption (-50%). No significant interaction effect (group-by-time) was revealed, and the effect of traction treatment was independent of the level of medication. During the 2-week follow-up at day 28, only the LT10 group improved (P < .05) in VAS (-52%) and EIFEL scores (-46%). During this period, no interaction effect (group-by-time) was identified, and the observed responses were independent of the level of medication. For this preliminary study, patients with acute lumbar sciatica secondary to disc herniation who received 2 weeks of lumbar traction reported reduced radicular pain and functional impairment and improved well-being regardless of the traction force group to which they were assigned. The effects of the traction treatment were independent of the initial level of medication and appeared to be maintained at the 2-week follow-up. Copyright © 2016. Published by Elsevier Inc.

A Search for Warriors: The Effects of Technology on the Air Force Ethos

DTIC Science & Technology

1997-04-01

quoted by Oberstleutnant Peter F. Hauser, and Lt Col John Rawls , C., and Maj. John C. Ornduff, “Lessons from the Kriegsakademie: A Reflection of the...Engagement: A Vision for the 21st Century Air Force. Washington DC: Headquarters USAF, November 1996. Hauser, Oberstleutnant Peter F., and Rawls , Lt Col...Modern Strategy from Machiavelli to the Nuclear Age. Princeton, NJ.: Princeton University Press, 1986. “Recent Space Issues and Development.” Air Force

Performance investigation on dissipative dielectric elastomer generators with a triangular energy harvesting scheme

NASA Astrophysics Data System (ADS)

Fan, Peng; Chen, Hualing; Li, Bo; Wang, Yongquan

2017-11-01

In this letter, a theoretical framework describing an energy harvesting cycle including the loss of tension (LT) process is proposed to investigate the energy harvesting performance of a dielectric elastomer generator (DEG) with a triangular energy harvesting scheme by considering material viscosity and leakage current. As the external force that is applied to the membrane decreases, the membrane is relaxed. When the external force decreases to zero, the condition is known as LT. Then the membrane undergoing LT can further relax, which is referred to as the LT process. The LT process is usually ignored in theoretical analysis but observed from energy harvesting experiments of DEGs. It is also studied how shrinking time and transfer capacitor affect the energy conversion of a DEG. The results indicate that energy density and conversion efficiency can be simultaneously improved by choosing appropriate shrinking time and transfer capacitor to optimize the energy harvesting cycle. The results and methods are expected to provide guidelines for the optimal design and assessment of DEGs.

Annual Expeditionary Warfare Conference (22nd)

DTIC Science & Technology

2017-10-24

for many copies of data and a unique software stack to operate on it. PSI designs and manufactures shipping and carrying cases as well as providing...An ISO 9001:2008 rated company, Trijicon Inc., is committed to Customer Satisfaction through the design , development, and manufacture of superior...their endeavors to continue as a world leader in the design and manufacture of high quality, innovative sighting systems. TABLE TOP dISPLAyErS 12 LtGen

High Frontier - The Journal for Space, Cyberspace & Missile Professionals. Volume 6, Number 1, November 2009

DTIC Science & Technology

2009-11-01

signs of just that!” In a response sent several days following Van Riper’s e-mail, [US Marine Corp Lt Gen James ] Mattis —who is now in the post Van...29 Regaining Credibility: Making Nuclear Sustainment a Model of Excellence Col James D. Fisher...Taverney, retired and Col James D. Rendleman, retired . . . . . . 53 Legislative Perspective Weapon Systems Acquisition Reform Act Maj Jung H. Ha

The Operational Level of War

DTIC Science & Technology

1985-12-01

efforts at destruction, and subsequent bridging operations in the let U.S. Army area are described. SBounds, Gary L., et al. Larger Units: Theater Army...modern commanders. Chervonobab, V. P., et al. Army Operations. Moscow: Ministry of Defense, 1977. DTIC ADB-070776L. This Soviet study contains case...maneuver and mobility. His work is of limited value today. Crittenberger, W. D., Lt. Gen., et al. "Mobility in the Field Army. Armor 60 (September-October

Airpower Leadership on the Front Line: Lt Gen George H. Brett and Combat Command

DTIC Science & Technology

2006-09-01

front.indd 5 11/7/06 10:29:42 AM insight into the makings of effective leadership and successful command. THOMAS HUGHES Associate Professor School...transformed impossibilities into tasks completed. My thesis reader, Dr. Thomas Hughes, lent his unerring sense of style and his gifted historical...project. The commandant, Col Thomas E. Griffith, provided papers pertaining to General Brett from his collection of historical documents. Dr. Harold R

TRADOC Annual Command History, 1 January to 31 December 1991

DTIC Science & Technology

1992-06-01

24th Infantry Division (Mechanized), the French 6th Light Armored Division, the 3d Armored Cavalry Regiment, and other units assigned; and VII Corps...under Lt. Gen. Frederick M. Franks, Jr., with the U.S. Ist Infantry Division (Mechanized), Ist and 3d Armored Divisions, the Ist Cavalry Division, the...Alma Ata, Kazakhstan, the presidents of all the former republics except Georgia and the three seceding Baltic states, declared formation of the

Special Inspector General for Iraq Reconstruction, Report to Congress, January 30, 2007

DTIC Science & Technology

2007-01-30

quarter that 114 border forts have been constructed thus far, and 5 points of entry have been completed.315 SIGIR’s ground project surveys ...security services.366 Lt. Gen. Dempsey recently estimated that 20-25% of the National Police “needed to be weeded out.”367 Finally, recent surveys ...sector development Transportation and Communications system, 33 site surveys have been completed for the communication towers between Mosul and

Defense Science Board Force Protection Panel Report to DSB

DTIC Science & Technology

1997-12-01

John Cowan, Jr., USMC USMC-MCCDC COL Dan Hahn, USA J-34 COL Hal Johnson, USA J-34 OPS Mr. Paul Kozemchak DARPA/ISO Mr. Roberto Mata ATSD(NCB)/CP CAPT...Ame Nelson, USN OPNAV N312 COL Robert Neubert , USA Army DCSOPS LtCol Roby, USAF AF/XOIIA Mr. John J. Sloan Defense Intelligence Agency Mr. Dan Spohn...Ame Nelson, USN 33. US Army Force Protection Budget: COL Robert Neubert , USA 34. US Marine Corps Force Protection Budget: LtCol Street, USMC 35. CBT

Air Force Smart Operations for the Twenty-first Century: Identifying Potential Failure Points in Sustaining Continuous Process Improvement across the Air Force

DTIC Science & Technology

2008-05-01

Dean Fred P. Stone, Lt Col, PhD, Director of Research John T. Ackerman, PhD, Series Editor Bill Polakowski, Lt Col, Essay Advisor Air University...the world go around, of that we both are sure. — Lyrics from “Money, Money” This line from the musical Cabaret highlights a certain truth in the

Alternate Futures for 2025. Security Planning to Avoid Surprise.

DTIC Science & Technology

1996-09-01

our thanks go to the 2025 study chairman, Lt Gen Jay W. Kelley, who provided great leadership and many helpful comments throughout the Alternate...Futures development. Also providing great leadership and countless hours of work to improve our product was the study director, Col Richard Szafranski. Dr...affairs. A Global worldview implies the US will seek a world leadership role. A TeK TeK was defined as the ability to employ technology. A TeK

Vice President Pence Tours Jet Propulsion Laboratory

NASA Image and Video Library

2018-04-28

U.S. Vice President Mike Pence, 2nd from left, poses for a group photograph with JPL Director Michael Watkins, left, JPL Deputy Director Lt. Gen. (Ret) Larry James, California Institute of Technology President Thomas Rosenbaum, JPL Distinguished Visiting Scientist and Spouse of UAG Chairman James Ellis, Elisabeth Pate-Cornell, and UAG Chairman, Admiral (Ret) James Ellis, right, after having toured NASA's Jet Propulsion Laboratory, Saturday, April 28, 2018 in Pasadena, California. Photo Credit: (NASA/Bill Ingalls)

The National Guard Ballistic Missile Defense Mission: Minutemen at the Orbital Plane

DTIC Science & Technology

2004-09-01

2001, he guided me through a change in Thesis Topic, an extension, an interruption while mobilized for Operation Enduring Freedom, the final extension...Command changes its focus.” Army News Service, Washington, DC. Copy obtained from the Internet at [http://www.defenselink.mil] (15 July 1996). 4...testing phase. 12 Kozaryn, Linda D., “Army Reserve Duty Has ’ Changed Forever’” The comments of US Army Reserve Chief, Lt. Gen. Thomas J. Plewes

Afghanistan: Narcotics and U.S. Policy

DTIC Science & Technology

2009-04-21

Purpose FY2008 Defense Appropriation P.L. 110-116 FY2008 Bridge Fund P.L. 110-161 (Division L ) FY2008 Supplemental P.L. 110-252 (Title...Glasser, “U.S. Backing Helps Warlord Solidify Power,” Washington Post, February 18, 2002; Ron Moreau and Sami Yousafzai, with Donatella Lorch, “Flowers of...dangers of narcotics use and to monitor and prevent drug use. Testimony of Lt. Gen. Walter L . Sharp, Director of Strategic Plans (J-5), Before the

Afghanistan: Narcotics and U.S. Policy

DTIC Science & Technology

2004-12-07

According to Lt. Gen. Walter L . Sharp, Director of Strategic Plans (J-5), the U.S. military contingent in Afghanistan “does not have the problem that the...although he declined to characterize Khan’s involvement. 60 Jason Barnes, “The Desert Village that Feeds UK’s Heroin Habit ,” The Observer (UK), December...Power,” Washington Post, Feb. 18, 2002; Ron Moreau and Sami Yousafzai, with Donatella Lorch, “Flowers of Destruction,” Newsweek, July 14, 2003; Andrew

JPRS Report, Soviet Union, Military Affairs

DTIC Science & Technology

1990-12-17

connection with the fact that they Irkutsk began throwing stones, bottles , and smoke bombs onto Lt Gen N. Kozlov, chief of the Central Food Directorate of the...elevators. The missile’s body is manufactured from fiber plastic (injection molded mate- The AGM-88B’s homing head is equipped with a rial) and consists...spiral antennas installed in a foam plastic radar and the same dimensions as the Martel. The new missile absorbing fairing which support operation of

Applications of Artificial Intelligence to the Strategic Defense Initiative’s Battle Management/Command and Control Objective.

DTIC Science & Technology

1985-09-01

technology issue is expected to take years of research (20:11). According to Lt Gen James A. Abrahamson, director of the SDI organization heading up...from occurring (14:79). A Wqhite House Panel known as the (Dr. James ) Fletcher Defensive Technologies Study Group has pointed out that, in the past...Handbook of Artificial Intelligence. Volume I. Los Altos CA: WilliamKaufmann Inc., 1981. 5. Basden , Andrew. "On the Application of Expert Systems,N

China Naval Modernization: Implications for U.S. Navy Capabilities - Background and Issues for Congress

DTIC Science & Technology

2014-06-05

September 30, 2011, press report, for example, quotes Lieutenant General Herbert Carlisle, the Air Force’s deputy chief of staff for operations, plans, and... Spencer Ackerman, “How To Kill China’s ‘Carrier-Killer’ Missile: Jam, Spoof And Shoot,” Danger Room (Wired.com), March 16, 2012, accessed online at...2011], Lt. Gen. Herbert J. Carlisle, the Air Force’s deputy chief of staff for operations, plans, and requirements, had said a public document

Summary of Proceedings and After Action Report DARCOM - Industry Executive Seminar Atlanta IX. Spring 1983.

DTIC Science & Technology

1983-03-02

all. 16. ATLANTA IX PANEL REPORT PANEL II - RESEARCH AND DEVELOPMENT PANELISTS: THE HONORABLE WALTER B. LABERGE !z VICE PRESIDENT, LOC L’EED MISSILES... STEVENS , USA COMMANDING GENERAL, US ARMY AVIATION RESEAFc?’ AND DEVELOPMENT CO NTNAND MGEN JOHN B. OBLINGERJ USA DEPUTY CHIEF OF STAFF FOR COMBAT...34Research and Development and the Tech- nology Base was co-chaired by Dr. W.B. LaBerge as industry leader and Lt. Gen. Robert J. Lunn, USA as DARCOM

Forward Arming and Refueling Points for Fighter Aircraft: Power Projection in an Antiaccess Environment

DTIC Science & Technology

2014-10-01

Arming and Refueling Points for Fighter Aircraft Feature Fifth-Generation Doolittle Raid If we should have to fight, we should be prepared to do so from...the neck up instead of from the neck down. —Gen Jimmy Doolittle The famous Doolittle Raid during World War II offers a superb exam- ple of how an...innovative concept can lead to strategic effects. On 18 April 1942, just four months after the Japanese attack on Pearl Harbor, Lt Col Jimmy Doolittle

The Effects of Incentive Programs on Clinical Productivity and Quality

DTIC Science & Technology

2009-02-04

outcome, such as a hemoglobin A1c ( HbA1c ) test result of 9% or less for a diabetic. Some models pay the bonus based on the overall number of tests...importance of accurate documentation. A final issue is related to P4P programs that provide bonuses for outcome measures, such as decreased HbA1c ...Diabetics with LDL  • Diabetics with HbA1c testing • Diabetics with HbA1c ɡ 41 Lt Gen Eric B

Mission Emphasis and the Determination of Needs for New Weapon Systems

DTIC Science & Technology

2009-05-01

Loveland, CO: Prosci, 2006). 61. Richard R. Nelson and Sidney G. Winter, An Evolutionary Theory of Economic Change (Cambridge, MA: The Belknap Press...of Gen Hunter Harris, USAF, (Ret.), by Col John E. Van Duyn and Maj Richard B. Clement, 7 July 1971. Typed transcript p. 32, K239.0512-403 Iris No...C. Jones, USAF, (Ret.) by Dr. Lt Col Maurice Maryanow and Dr. Richard H. Kohn, 5 August, 15-17 October 1985; 20-21 January, 13-14 March 1986

History of the Great Patriotic War of the Soviet Union, 1941-1945, Volume 4

DTIC Science & Technology

1982-08-20

USSR, col. 233, inv. 2374, div. 39, P. 335. -335-K, Goduny the soldiers saw a child with a label on his neck: "Goduny 121.14 When they attempted to...corps commanded by Lt. Gen, L.A. Porn advanced particularly rapidly. The corps, formed in 1942, was the first to enter the battle with the German fascist...Party for , families with many children and for the protection of motherhood and child - * hood& The Soviet government increased allowances to mothers

Command History, 1971. Volume 1. Sanitized

DTIC Science & Technology

1971-01-01

of 1971. During this period USAF A-lEs, F-4s, B-52s, and AC-ll9Gs provided interdiction, armed reconnaissance, and ground support to MAJ GEN Vang Pao’s...tribesmen. The ground situation was critical as GEN Pao was swept off the Plain of Jars and back almost to Luang Prabang, the royal capital of Laos...friendly forces. The seriousness of the situation in northern Zaos had subsided and GEN Pao’s forces were retaking ground lost earlier in a repeat of

The US Army and Security Force Assistance: Assessing the Need for an Institutionalized Advisory Capability

DTIC Science & Technology

2009-03-03

Army Special Forces. Following a 2008 meeting with Gen James N. Mattis (Commander, US Joint Forces Command), Gen James T. Conway (Commandant, US...CAPABILITY Approved by: , Thesis Committee Chair James B. Martin, Ph.D. , Member Gary J. Bjorge, Ph.D. , Member Robert D...Technology: Information technology, bio -technology, weaponry, increased access to information Demographic Changes: Population growth, youth bulge

The Procurement of Non Developmental Items: Pros and Cons

DTIC Science & Technology

1994-09-01

commercial way of procurement will bring more advantages than disadvantages to DOD. The list of the pros greatly outweighs the cons . There is practically...AD-A285 009 MH PROCUREMENT OF NON DEVELOPMENTAL ITEMS: PROS AND CONS THES IS Giorgio Scappaticci. Lt. Col., Italian Air Force AFIT/GLMILALj94S-3 I...PROS AND CONS U;narmou,.ced 0 Justification THESIS Giorgio Scappaticci, Lt. Col., Italian Air Force Dist’ibution f Availability Codes AFIT/GLM/LAL

The effects of finishing diet and postmortem ageing on the eating quality of the M. longissimus thoracis of electrically stimulated Brahman steer carcasses.

PubMed

Bruce, H L; Stark, J L; Beilken, S L

2004-06-01

Beef from cattle finished on grass will be of similar quality to that from cattle finished on grain when their carcasses are processed using best practice protocols. To test this hypothesis, carcasses of twenty Brahman steers, finished to 400 kg live weight on either Buffel grass pasture (n=10) or grain (n=10), were electrically stimulated with 400 V for 50 s 45 min postmortem, and their beef quality assessed 1 and 14 days postmortem. Hot weight, rump subcutaneous fat thickness and animal rate of growth in the 205 days preceding slaughter were recorded for each carcass as potential influences on beef quality. Quality of the M. longissimus thoracis (LT) at 1 and 14 days postmortem was evaluated using peak Warner-Bratzler shear force, compression, pH, cooking loss and taste panel acceptability, as well as by moisture and crude fat contents measured at 1 day postmortem. Results showed that steers finished on pasture grew the slowest and had the least subcutaneous fat at the same carcass weight. LT from carcasses of steers finished on pasture also had the shortest mean sarcomere lengths, suggesting these muscles may have been cold-affected, but there was no effect of diet on peak shear force. LT from carcasses of steers finished on pasture had the highest mean compression value, possibly because of increased collagen cross-linking associated with slow growth or increased exercise. Ageing significantly decreased LT peak shear force and compression values and increased cooking loss, L (∗), a (∗) and b (∗) values. Taste panellists rated the aged, grass-finished beef the most tender and the best quality; however, the taste panel in this study may have favoured LT from grass-finished steers because it was significantly juicier than LT from the grain-finished steer carcasses. These results indicated that carcass composition and processing conditions interact to exert a greater effect on LT toughness and sensory acceptability than finishing diet. Ageing LT from steers finished on grass improved its colour, and thus may enhance its consumer acceptability.

ForceGen 3D structure and conformer generation: from small lead-like molecules to macrocyclic drugs

NASA Astrophysics Data System (ADS)

Cleves, Ann E.; Jain, Ajay N.

2017-05-01

We introduce the ForceGen method for 3D structure generation and conformer elaboration of drug-like small molecules. ForceGen is novel, avoiding use of distance geometry, molecular templates, or simulation-oriented stochastic sampling. The method is primarily driven by the molecular force field, implemented using an extension of MMFF94s and a partial charge estimator based on electronegativity-equalization. The force field is coupled to algorithms for direct sampling of realistic physical movements made by small molecules. Results are presented on a standard benchmark from the Cambridge Crystallographic Database of 480 drug-like small molecules, including full structure generation from SMILES strings. Reproduction of protein-bound crystallographic ligand poses is demonstrated on four carefully curated data sets: the ConfGen Set (667 ligands), the PINC cross-docking benchmark (1062 ligands), a large set of macrocyclic ligands (182 total with typical ring sizes of 12-23 atoms), and a commonly used benchmark for evaluating macrocycle conformer generation (30 ligands total). Results compare favorably to alternative methods, and performance on macrocyclic compounds approaches that observed on non-macrocycles while yielding a roughly 100-fold speed improvement over alternative MD-based methods with comparable performance.

Effect of dysprosium and lutetium metal buffer layers on the resistive switching characteristics of Cu-Sn alloy-based conductive-bridge random access memory.

PubMed

Vishwanath, Sujaya Kumar; Woo, Hyunsuk; Jeon, Sanghun

2018-06-18

Conductive-bridge random access memory (CBRAM) has become one of the most suitable candidates for non-volatile memory in next-generation information and communication technology. The resistive switching mechanism of CBRAM depends on the formation/annihilation of the conductive filament (CF) between the active metal electrode and the inert electrode. However, excessive ion injection from the active electrode into the solid electrolyte is reduces the uniformity and reliability of the resistive switching devices. To solve this problem, we investigated the resistive switching characteristics of a modified active electrode with different compositions of Cu_x-Sn_{_1-x}(0.13 < X < 0.55). The resistive switching characteristics were further improved by inserting a dysprosium (Dy) or lutetium (Lu) buffer layer at the interface of Cu_x-Sn_1-x/Al₂O₃. Electrical analysis of the optimal Cu_0.27-Sn_0.73/Lu-based CBRAM exhibited stable resistive switching behavior with low operation voltage (SET: 0.7 V and RESET: -0.3 V), a high on/off resistive ratio (10⁶), cyclic endurance (>10⁴), and long-term retention (85℃/10 years). To achieve these performance parameters, CFs were locally formed inside the electrolyte using a modified CuSn active electrode, and the amount of Cu-ion injection was reduced by inserting the Dy or Lu buffer layer between the CuSn active electrode and the electrolyte. In particular, conductive-atomic force microscopy results at the Dy/ or Lu/Al₂O₃ interface directly showed and defined the diameter of the CF. © 2018 IOP Publishing Ltd.

Probe And Drogue Aerial Refueling Requirements: How Will Air Force Special Operations Command Meet Future Demands?

DTIC Science & Technology

2002-06-01

consists of a torque meter assembly, a 14-stage axial compressor with variable guide vanes, an annular combustor, a two-stage gas generator turbine, a two...married to Laura Shapland née Howells of Salisbury, England. iii ACKNOWLEDGEMENTS I would like to acknowledge several people...up this project and submitted it to Air University for a thesis topic: Lt Col Neil Billings, Lt Col Tracey Goetz, Lt Col Scott Howell , and Maj Jon

Satellite bulk tropospheric temperatures as a metric for climate sensitivity

NASA Astrophysics Data System (ADS)

Christy, John R.; McNider, Richard T.

2017-11-01

We identify and remove the main natural perturbations (e.g. volcanic activity, ENSOs) from the global mean lower tropospheric temperatures ( T LT ) over January 1979 - June 2017 to estimate the underlying, potentially human-forced trend. The unaltered value is +0.155 K dec-1 while the adjusted trend is +0.096 K dec-1, related primarily to the removal of volcanic cooling in the early part of the record. This is essentially the same value we determined in 1994 (+0.09 K dec-1, Christy and McNider, 1994) using only 15 years of data. If the warming rate of +0.096 K dec-1 represents the net T LT response to increasing greenhouse radiative forcings, this implies that the T LT tropospheric transient climate response (Δ T LT at the time CO2 doubles) is +1.10 ± 0.26 K which is about half of the average of the IPCC AR5 climate models of 2.31 ± 0.20 K. Assuming that the net remaining unknown internal and external natural forcing over this period is near zero, the mismatch since 1979 between observations and CMIP-5 model values suggests that excessive sensitivity to enhanced radiative forcing in the models can be appreciable. The tropical region is mainly responsible for this discrepancy suggesting processes that are the likely sources of the extra sensitivity are (a) the parameterized hydrology of the deep atmosphere, (b) the parameterized heat-partitioning at the oceanatmosphere interface and/or (c) unknown natural variations.

U.S. Department of Defense Official Website

Science.gov Websites

updated and may no longer be applicable as a result of changes in law, regulation and/or administration changes to the U.S. military's global posture. Rumsfeld and Joint Chiefs Chairman Air Force Gen. Richard B . Myers discussed the changes. Air Force Gen. Richard B. Myers, chairman, Joint Chiefs of Staff, answers

Setup: What the Air Force Did in Vietnam and Why

DTIC Science & Technology

1991-06-01

4, no. 2 (Fall 1950) : 12 . 18 . Ibid . 19 . Giulio Douhet, The Command ofthe Air, trans . Dino Ferrari, reprinted by the Office of Air Force History...demilitarized zone (DMZ). Ironically, in November 1954, Gen Tran Van Don and other leading Vietnamese generals suggested that the MAAG organize their...Office ofAir Force History, 1981), 36. 37 . Ibid., 49-50. 38 . According to formerSouth Vietnamese minister ofnational defense Gen Tran Van Don, he and

Vice President Pence Tours Jet Propulsion Laboratory

NASA Image and Video Library

2018-04-28

JPL Director Michael Watkins, standing, explains the history of NASA's Jet Propulsion Laboratory and the use of the Mission Support Area to Vice President Mike Pence, seated next to his wife Karen and daughter Charlotte Pence, during a tour of JPL, Saturday, April 28, 2018 in Pasadena, California. Joining the Vice President was, JPL Distinguished Visiting Scientist and Spouse of UAG Chairman James Ellis, Elisabeth Pate-Cornell, left, UAG Chairman, Admiral (Ret) James Ellis, JPL Deputy Director Lt. Gen. (Ret) Larry James, and California Institute of Technology President Thomas Rosenbaum. Photo Credit: (NASA/Bill Ingalls)

Vice President Pence Tours Jet Propulsion Laboratory

NASA Image and Video Library

2018-04-28

U.S. Vice President Mike Pence, 3rd from right, tours NASA's Jet Propulsion Laboratory along with his wife Karen, and daughter Charlotte, Saturday, April 28, 2018 in Pasadena, California. Joining the Vice President t and his family on the tour are: UAG Chairman, Admiral (Ret) James Ellis , left, JPL Distinguished Visiting Scientist and Spouse of UAG Chairman James Ellis, Elisabeth Pate-Cornell, behind Mrs. Pence, California Institute of Technology President Thomas Rosenbaum, JPL Director Michael Watkins, and JPL Deputy Director Lt. Gen. (Ret) Larry James, right. Photo Credit: (NASA/Bill Ingalls)

Vice President Pence Tours Jet Propulsion Laboratory

NASA Image and Video Library

2018-04-28

U.S. Vice President Mike Pence can be seen with his wife Karen Pence as they toured NASA's Jet Propulsion Laboratory, Saturday, April 28, 2018 in Pasadena, California. The vice President was also joined by his daughter Charlotte Pence, JPL Distinguished Visiting Scientist and Spouse of UAG Chairman James Ellis, Elisabeth Pate-Cornell , UAG Chairman, Admiral (Ret) James Ellis , Executive Director of the National Space Council Scott Pace, JPL Deputy Director Lt. Gen. (Ret) Larry James, and California Institute of Technology President Thomas Rosenbaum. Photo Credit: (NASA/Bill Ingalls)

The Temporal and Scalar Mechanics of Conflict: Strategic Implications of Speed and Time on the American Way of War

DTIC Science & Technology

2006-03-15

variable speed” in terms of an operational pause? Just as Copernicus and Galileo ushered a paradigm shift into a world convinced that a geocentric ...Reimer’s POC, Lt Col John Medve, probably created and staffed the report for CSA, but it was signed by Gen. Reimer. The paper also noted that keeping the...and not geocentric (Earth-centered). His beliefs were in direct conflict with the religious and philosophical dogma of the period that saw Man as

DefenseLink.mil - Special Report - 35 Years of Volunteer Forces - July 1,

Science.gov Websites

force, when many in the military were convinced the system would fail. Yet after the volunteer military volunteer service Our nation is fortunate that so many talented and patriotic young people have stepped Photo of Gen. George W. Casey Jr. When Gen. George W. Casey Jr. became chief of staff of the Army in

Model for Evaluating the Cost Consequences of Deferring New System Acquisition Through Upgrades

DTIC Science & Technology

1999-07-01

Analysis & Evaluation The Pentagon Washington, DC 20301 Attn: Mr. Eric Coulter, Director Projection Forces Division, Room 2E314 Lt Col Kathleen Conley...1034 Office of the Air National Guard ANG/AQM 5109 Leesburg Pike Skyline VI, Suite 302A Falls Church, VA 22041-3201 Attn: Col Brent Marler 1 Lt Col

KSC-07pd3062

NASA Image and Video Library

2007-11-01

KENNEDY SPACE CENTER, FLA. -- Ready to put spades to work at ground-breaking ceremonies for SpaceX's new Falcon 9 rocket launch facilities at Space Launch Complex 40 at Cape Canaveral are (from left) Thad Altman, Florida State representative; Jeff Kottkamp, Florida State Lt. Governor; Elon Musk, founder and CEO of Space Exploration Technologies; Brig. Gen. Susan J. Helms, commander of the U.S. Air Force 45th Space Wing; Lynda Weatherman, Brevard County Economic Development Commission CEO and president; Steve Koehler, president of Space Florida; Janet Petro, deputy director of NASA Kennedy Space Center; Patricia Grace Smith, FAA associate administrator for Commercial Space Transportation; and Steve Cain, NASA Kennedy Space Center COTS project manager. As part of NASA’s Commercial Orbital Transportation Services, or COTS, competition, SpaceX will launch a Falcon 9 with a cargo-carrying payload on a series of three demonstration missions from Cape Canaveral to the International Space Station, culminating with the delivery of supplies to the $100 billion dollar orbiting laboratory. SpaceX intends to demonstrate its launch, maneuvering, berthing and return abilities by 2009 – a year before NASA has scheduled the conclusion of Space Shuttle operations. Photo credit: NASA/George Shelton

Micro- and nanodomain imaging in uniaxial ferroelectrics: Joint application of optical, confocal Raman, and piezoelectric force microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shur, V. Ya., E-mail: vladimir.shur@urfu.ru; Zelenovskiy, P. S.

2014-08-14

The application of the most effective methods of the domain visualization in model uniaxial ferroelectrics of lithium niobate (LN) and lithium tantalate (LT) family, and relaxor strontium-barium niobate (SBN) have been reviewed in this paper. We have demonstrated the synergetic effect of joint usage of optical, confocal Raman, and piezoelectric force microscopies which provide extracting of the unique information about formation of the micro- and nanodomain structures. The methods have been applied for investigation of various types of domain structures with increasing complexity: (1) periodical domain structure in LN and LT, (2) nanodomain structures in LN, LT, and SBN, (3)more » nanodomain structures in LN with modified surface layer, (4) dendrite domain structure in LN. The self-assembled appearance of quasi-regular nanodomain structures in highly non-equilibrium switching conditions has been considered.« less

Pulmonary function in individuals who underwent liver transplantation: from the US cystic fibrosis foundation registry.

PubMed

Miller, Melissa R; Sokol, Ronald J; Narkewicz, Michael R; Sontag, Marci K

2012-05-01

Severe liver disease affects 4.5% to 10% of individuals with cystic fibrosis (CF) and is the third-leading cause of death. Liver transplantation (LT) is an accepted therapy, but the effects of liver disease and LT on pulmonary function in patients with CF are controversial. Our aim was to characterize changes in pulmonary function in LT patients with CF. Using mixed effect models, we analyzed pulmonary function before and after transplantation in 168 LT patients and 840 non-LT patients with CF who were matched by age, sex, pancreatic status, infections with US CF Foundation Patient Registry data (1989-2007). The primary outcome was the change in the forced expiratory volume in 1 second (FEV(1); percent predicted) in LT and non-LT in the 3-years periods before or after transplantation; second we compared FEV(1) changes. In the 3 years before transplantation, LT had lower initial FEV(1) values (71.5% ± 1.9%, P < 0.001) and a slower decline (+0.1% ± 0.4%/year, P < 0.001) than non-LT (79.6% ± 1.3% and -1.3% ± 0.2%/year, respectively). There was no difference in the FEV(1) decline after transplantation (-1.4% ± 0.4%/year for LT versus -2.1% ± 0.2%/year for non-LT, P = 0.14). Both the (P = 0.003) and (P = 0.001) had a slower FEV(1) decline in the period before transplantation versus after transplantation. In conclusion, pulmonary function is lower and declines more slowly in patients with CF before LT versus, but parallels the decline in non-LT after transplantation. LT is neither beneficial nor detrimental to pulmonary function in CF but returns FEV(1) decline to the same trajectory found for matched non-LT individuals with CF. Copyright © 2012 American Association for the Study of Liver Diseases.

Optimizing Air Force Depot Programming to Maximize Operational Capability

DTIC Science & Technology

2014-03-27

MONITORING AGENCY NAME(S) AND ADDRESS(ES) AF/A4/ 7P Lt Col Dana C. Pelleltier, dana.c.pelletier2.mil@mail.mil, (703) 693-8395 Lt Col Robert L...Charlesworth, robert.charlesworth@pentagon.af.mi Maj Steven N. Lamb, steven.lamb@pentagon.mil, (703) 695-7049 10. SPONSOR/MONITOR’S ACRONYM(S) AF/A4/ 7P 11

Forecasting Foreign Currency Exchange Rates for Air Force Budgeting

DTIC Science & Technology

2015-03-26

FORECASTING FOREIGN CURRENCY EXCHANGE RATES FOR AIR FORCE BUDGETING THESIS MARCH 2015...States. AFIT-ENV-MS-15-M-178 FORECASTING FOREIGN CURRENCY EXCHANGE RATES FOR AIR FORCE BUDGETING THESIS Presented to the Faculty...FORECASTING FOREIGN CURRENCY EXCHANGE RATES FOR AIR FORCE BUDGETING Nicholas R. Gardner, BS Captain, USAF Committee Membership: Lt Col Jonathan

2001 Industry Studies: Munitions

DTIC Science & Technology

2001-01-01

Lt Col Michael P. Howe, USAF Lt Col William E . MacLure, USAF Mr. Terrence K. May, Dept of the Air Force LTC Paul M. McQuain, USA CDR David L. Prater...USN CAPT Steven K. Tucker, USN Lt Col Richard L. Wojick , Jr., USAF Mr. Michael J. Yurina, Dept of the Navy Dr. Thomas C. Hone, faculty CAPT Ralph...FY98 FY99 FY00 FY01 FY02 FY03 FY04 FY05 FY 00 $ BI LL IO N RDT& E - S&T (Far-Term) RDT& E - Development (Near- and Mid-Term) Procurement (Near-Term) 6 As

Vice President Pence Tours Jet Propulsion Laboratory

NASA Image and Video Library

2018-04-28

JPL Director Michael Watkins, left, explains the history of NASA's Jet Propulsion Laboratory and the use of the Mission Support Area to Vice President Mike Pence, seated 4th from left, during a tour of JPL, Saturday, April 28, 2018 in Pasadena, California. Joining the Vice President was, JPL Distinguished Visiting Scientist and Spouse of UAG Chairman James Ellis, Elisabeth Pate-Cornell, left, UAG Chairman, Admiral (Ret) James Ellis, Executive Director of the National Space Council Scott Pace, wife of Mike Pence, Karen Pence, daughter of Mike Pence, Charlotte Pence, and JPL Deputy Director Lt. Gen. (Ret) Larry James. Photo Credit: (NASA/Bill Ingalls)

Latin American Instability: A Major Threat To The US

DTIC Science & Technology

2008-04-04

release. Distribution is unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT Latin  America  is a neighbor to the  US  within the western hemisphere...The close proximity and the  economic reliance between the  US  and Latin  America  make its development essential to our national interests of  security...04 April 2008 Thesis Advisor: Charles Cunningham, Lt Gen (ret), USAF i ABSTRACT Latin America is a neighbor to the US within the

Joint Force Quarterly. Number 19, Summer 1998

DTIC Science & Technology

1998-08-01

Shelton, USA Publisher ADVISORY COMMITTEE LTG Richard A. Chilcoat, USA ■ National Defense University Chairman BG David A. Armstrong, USA (Ret.) ■ Office of...College Maj Gen Richard L. Engel, USAF ■ Industrial College of the Armed Forces Maj Gen Timothy A. Kinnan, USAF ■ Air War College Col David M. Lumsden...BOARD Hans Binnendijk ■ National Defense University Chairman Richard K. Betts ■ Columbia University Col J. Lee Blank, USAF ■ National War College Col

The United States Air Force in Southeast Asia. The War in South Vietnam. The Years of the Offensive 1965-1968

DTIC Science & Technology

1988-01-01

principle of introducing an international force, he had to discuss it with Maj. Gen. Tran Van Minh and Maj. Gen. Nguyen Van Thieu of the Armed Forces...from it within 2 days. Another attack in August on the camp at Duc Co was beaten back, largely by 280 tactical strike sorties. The final major enemy... Duc Co CORPS Nha Trang [3 CORPS Cam Ranh Bay Loc Ninh - 0 operation )’ Elp 4’Wng Vl pTo _fongN Ar0 ofPrloqe Cnfonat AttleMlbaroorroourdr ar Bate 138

Additional Haptic Information Provided by Anchors Reduces Postural Sway in Young Adults Less Than Does Light Touch

PubMed Central

Moraes, Renato; Bedo, Bruno L. S.; Santos, Luciana O.; Batistela, Rosangela A.; Santiago, Paulo R. P.; Mauerberg-deCastro, Eliane

2018-01-01

This study investigated the effect of adding haptic information to the control of posture, as well as comparing the effect of both the “light touch” (LT) and “anchor system” (AS) paradigms on postural sway. Additionally, it compared the effect of location and number of points of contact to the control of posture in young adults. The location consisted of using the anchors tied to the finger and held by the hands, and, for LT, the fingertip. For the number of points of contact, participants used two hands, and then separately the dominant hand, and the non-dominant hand, for both anchor and LT paradigms. Participants stood upright with feet-together and in tandem position while performing tasks that combined the use of anchors and LT, points of contact (hand grip and finger), and number of points of contact (two hands and one hand). In this study, the anchors consist of holding in each hand a flexible cable with the other end attached to the ground. The LT consists of slightly touching a rigid surface with the tip of the index finger. The results showed, first, that the anchors improved postural control less than did the LT. Second, they revealed that holding the anchors with the hands or with them tied to the fingertip resulted in a similar reduction in postural sway only in the tandem position. For the feet-together position, the anchors tied to the fingertip were ineffective. Similarly, the use of one or two hands did not affect the contribution of the anchors. However, using two hands in the LT condition was more effective than was one hand. Third, our results showed the presence of a temporal delay between force and center-of-pressure (COP) for the anchors, only in the AP direction with feet-together. In conclusion, overall, the anchors were less effective in reducing postural sway than was the LT. The anchors attached to fingertips were as effective as the hand-held anchors in the tandem position, yet ineffective during foot-together standing. Force-COP timing explains reduced postural sway with LT but not for the anchor; hence, exploratory and supra-postural components may be involved. PMID:29922122

City of Freeport, Florida, State Road 20 Water Main Installation, Final Environmental Assessment, Eglin Air Force Base, Florida

DTIC Science & Technology

2010-07-01

tracked Species, Eglin AFB Scientific Name Common Name Status State Federal Fish Acipenser oxyrinchus desotoi Gulf Sturgeon LS LT Awaous banana River...West’s Flax LE - Litsea aestivalis Pondspice LE - Lupinus westianus Gulfcoast Lupine LT - Macranthera flammea Hummingbird Flower LE - Magnolia ashei...Pinguicula primuliflora Primrose- Flowered Butterwort LE - Platanthera integra Southern Yellow Fringeless Orchid LE - Polygonella macrophylla Large-Leaved

Land Combat Systems Industry Study 2004

DTIC Science & Technology

2004-01-01

David Barnhart, Florida Air National Guard Lt Col Warren Anderson, United States Air Force Lt Col Phillip Chudoba, United States Marine Corps Mr...beginning with the current condition of GD. CURRENT CONDITION In the business world, the rearview mirror is always clearer than the windshield. Warren ... Buffett The ICAF coursework and field trips presented the study team with ample historic data for assessing the current condition of the LCS firms

Norway’s Challenges In the High North

DTIC Science & Technology

2016-02-16

currently a student at the Air War College , Air University, Maxwell AFB, Alabama . iv Abstract Norway has an extensive coastline; facing the North...AIR WAR COLLEGE AIR UNIVERSITY NORWAY’S CHALLENGES IN THE HIGH NORTH by Liv Judith Olsen, Lt Col, Royal Norwegian Air Force A...military education, Lt Col Olsen graduated from the RNoAF Academy and the Norwegian Defence Command and Staff College (2010-2011), a professional

A Review of Regional Development Theory

DTIC Science & Technology

1989-03-20

Editorial Review by Lt Col James R. Aubrey Department of English USAF Academy, Colorado 80840 This research report is presented as a competent treatment of...the subject, worthy of publication. The United States Air Force Academy vouches for the quality of the research , without * necessarily endorsing the...to the National Technical Information Service. pTle This research report has been reviewed and is approved for publication. RICHARD DURHAM, Lt Col

Unmanned Airlift: How Should We Proceed?

DTIC Science & Technology

2002-04-01

Research Report Submitted to the Faculty In Partial Fulfillment of the Graduation Requirements Advisor: Lt Col Vincent T. Jovene Maxwell Air Force Base...thank my research advisor, Lt Col Jim Jovene for his guidance and assistance. I also owe a special thanks to Mr. Bob Peak of the Southeast SATS Lab...National Aerospace System ( NAS ) are driving the advancement of automating technologies, and it shows how this drive toward automation is laying the

Effect of Elastase-induced Emphysema on the Force-generating Ability of the Diaphragm

PubMed Central

Supinski, Gerald S.; Kelsen, Steven G.

1982-01-01

The effect of emphysema on the ability of the diaphragm to generate force was examined in costal diaphragm muscle strips from 10 Golden hamsters killed 18 mo after intratracheal injection of pancreatic elastase in a dose producing hyperinflation (mean total lung capacity [TLC] = 163% of control) and generalized panacinar emphysema. 13 saline-injected normal animals served as controls. The time course of isometric tension and the effect of alterations in muscle fiber and sarcomere length on the isometric tension (T) generated in response to tetanizing electrical stimuli (length-tension [L-T] relationship) were examined. Elastase administration caused an increase in diaphragm muscle thickness and reduction in the length of costal diaphragm muscle fibers measured in situ. Emphysema significantly increased the maximum tetanic tension as a result of hypertrophy. Maximal tension corrected for increases in muscle cross-sectional area (T/cm2), however, was the same in emphysematous (E) and control (C) animals. Emphysema also shifted the muscle fiber L-T curve of the diaphragm but not of a control muscle, the soleus, toward shorter lengths. In contrast to the effects of E on the diaphragm muscle fiber L-T curve, the sarcomere L-T curve was the same in E and C. Since the length at which tension was maximal correlated closely with sarcomere number (r = 0.94; P < 0.001) reduction in the number of sarcomeres in series in muscles from emphysematous animals appeared to explain the shift in the muscle fiber L-T curve. We conclude that in elastase-induced emphysema adaptive changes both in diaphragm cross-sectional area and sarcomere number augment the force-generating ability of the diaphragm. We speculate that changes in sarcomere number compensate for alterations in muscle fiber length resulting from chronic hyperinflation of the thorax, while diaphragmatic muscle hypertrophy represents a response to changes in respiratory load and/or diaphragm configuration (LaPlace relationship). Images PMID:6922866

Historical Lessons of Air Force Communications

DTIC Science & Technology

2010-12-01

AU/ACSC/ CUSTINE /AY10 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY HISTORICAL LESSONS OF AIR FORCE COMMUNICATIONS...by Jay D. Custine , Civ, DAF A Research Report Submitted to the Faculty In Partial Fulfillment of the Graduation...Requirements Advisor: Lt Col Paul E. Griffith Maxwell Air Force Base, Alabama December 2010 AU/ACSC/ CUSTINE /AY10 ii

Lucrative Targets: The U.S. Air Force in the Kuwaiti Theater of Operations

DTIC Science & Technology

2001-01-01

led initially by Brig. Gen. Frederic N. Buckingham and, after November 11, by Brig. Gen. Edwin E. Tenoso—had the same responsibility for MAC/Commander...117s destroying vital C2 centers and the Navy’s Tomahawk Land Attack Missiles (TLAMs) hitting electrical powerplants, the presidential palace , the Ba‘ath...By the opening of the Iran-Iraq War in September 1980, the Iraqi dictator had increased his elite force to two brigades of palace guards, and during

Replication Stress and Mitotic Dysfunction in Cells Expressing Simian Virus 40 Large T Antigen

PubMed Central

Hu, Liang; Filippakis, Harilaos; Huang, Haomin; Yen, Timothy J.

2013-01-01

We previously demonstrated that simian virus 40 (SV40) large T antigen (LT) binds to the Bub1 kinase, a key regulator of the spindle checkpoint and chromosome segregation. Bub1 mutations or altered expression patterns are linked to chromosome missegregation and are considered to be a driving force in some human cancers. Here we report that LT, dependent on Bub1 binding, causes micronuclei, lagging chromatin, and anaphase bridges, which are hallmarks of chromosomal instability (CIN) and Bub1 insufficiency. Using time-lapse microscopy, we demonstrate that LT imposes a Bub1 binding-dependent delay in the metaphase-to-anaphase transition. Kinetochore fibers reveal that LT, via Bub1 binding, causes aberrant kinetochore (KT)-microtubule (MT) attachments and a shortened interkinetochore distance, consistent with a lack of tension. Previously, we showed that LT also induces the DNA damage response (DDR) via Bub1 binding. Using inducible LT cell lines, we show that an activated DDR was observed before the appearance of anaphase bridges and micronuclei. Furthermore, LT induction in serum-starved cells demonstrated γ-H2AX accumulation in cells that had not yet entered mitosis. Thus, DDR activation can occur independently of chromosome segregation defects. Replication stress pathways may be responsible, because signatures of replication stress were observed, which were attenuated by exogenous supplementation with nucleosides. Our observations allow us to propose a model that explains and integrates the diverse manifestations of genomic instability induced by LT. PMID:24067972

The ’In Lieu Of’ Myth. Airmen in Joint Ground Operations (Walker Paper, Number 13)

DTIC Science & Technology

2009-01-01

Romano, Dains , and Watts, “Air Force Breaks New Ground,” 14. 25. Air Force Print News, “Dangerous Road to Progress,” 42; and Air Force Print News...92 Romano, Lt Col Joseph L., III; Capt William M. Dains ; and Capt David T. Watts, “Air Force Breaks New Ground at Camp Bucca, Iraq.” Military

78 FR 35876 - Notice of Intent To Seek Public and Private Organizations, Associations, and Other Entities Which...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

.... Military and Host Nation Maritime Security Forces' Exercise Fidelity and Effectiveness, and To Improve... after contact. FOR FURTHER INFORMATION CONTACT: AFRICOM J9--Outreach Directorate, +49 711-729-3260 LtCol... Series Exercises in order to familiarize U.S. forces and Host Nation Maritime forces with public and...

Command Sgt. Maj. John Wayne Troxell > Joint Chiefs of Staff > Article View

Science.gov Websites

DOCNET Leadership CJCS | Gen. Dunford on Flickr VCJCS | Gen. Selva on Flickr SEAC | CSM Troxell on J8 | Force Structure, Resources & Assessment Contact Home : Leadership : Article View Command Sgt includes Ranger, Airborne, Jumpmaster, Pathfinder, the Primary Leadership Development Course, the Basic

United States Air Force Security Forces in an Era of Terrorist Threats

DTIC Science & Technology

1999-06-01

their primary duties. The third alternative is to eliminate the Palace Tenure deployments of security personnel and replace them with dedicated units...The Phoenix Raven program, the 820th Security Forces Group, and Palace Tenure commitments. The specified mission varies by organization, but the...820th Security Forces Group. January 1999, slide 4. 166 Statement of LT. Col. Larry A. Buckingham , 820th Security Forces Group Commander, “820th Security

Military Operations in the Italian East Africa, 1935-1941: Conquest and Defeat

DTIC Science & Technology

2009-01-01

a more realistic and enlightening policy and received total approval by his new vice viceroy Gen. Guglielmo Nasi , former governor of Rarar, who...command of Gen. Nasi , begun the invasion of British Somaliland against a force of 5,000 British and coalition troops.?? Mter 17 days" ... the vexatious...had not yet committed to the fight or the region of Gondar where the Gen. Guglielmo Nasi was capable to put in place an effective and well prepared

Joint Task Force - Port Opening: Can this Emerging Capability Expedite Operational Objectives Throughout the Range of Military Operations?

DTIC Science & Technology

2009-10-26

for Acquisition, Technology, and Logistics, 30 July 2007). 16 Craig Koontz , ―U.S. Transportation Command,‖ PowerPoint, 23 September 2009, Newport, RI...Support Group. To Lt Col Michael W. Pratt, Naval War College. Memorandum, 30 September 2009. Koontz , Craig. ―U.S. Transportation Command...PowerPoint. 23 September 2009. 22 Koontz , Craig. Contractor/Advisor to CDR U.S. Transportation Command. To Lt Col Michael W. Pratt, 28

Pullout of a Rigid Insert Adhesively Bonded to an Elastic Half Plane.

DTIC Science & Technology

1983-12-01

COMMAND UNITED STATES AIR FORCE C-= °84 02 13 071. C,, W % d 6 This document was prepared by the Department of Engineering Mechanics, USAF Academy Faculty...THOMAS E. KULLGREN, Lt Col, USAF Project Engineer /Scientist Professor and Acting Head, Department of Engineering Mechanics KENNETH E. SIEGETH Lt Col...Department of Engineering (Ifapphicable) Mechanics USAFA/DFEM 6c. ADDRESS (City. State and ZIP Code) 7b. ADDRESS (City, Slate and ZIP Code) USAF Academy

The Development and Inter-Rater Reliability of the Department of Defense Human Factors Analysis and Classification System, Version 7.0

DTIC Science & Technology

2015-04-09

Anthony Wurmstein, Lt Col Brian (Moose) Musselman, & Maj Alejandro Ramos (U.S. Air Force). Finally, Lt Col Mary E. Arnholt and Maj Ernest Herrera, Jr ...Wright- Patterson AFB, OH 45433-7913 Distribution A: Approved for public release; distribution is unlimited. Case Number: 88ABW-2015-2334, 12...School of Aerospace Medicine Aerospace Medicine Department Aerospace Education Branch 2510 Fifth St. Wright- Patterson AFB, OH 45433-7913 8

Environmental Assessment: Military Family Housing Privatization Maxwell Air Force Base

DTIC Science & Technology

2005-06-01

Ray L. Raton Mildred J . Worthy February 9, 2005 Lt. Colonel David W. Maninez Deputy Commander, 42nd MSG 50 South LeMay Plaza (Bldg 804) Maxwell ...Environmental Assessment Military Family Housing Privatization Maxwell Air Force Base United States Air Force Air Education and Training Command... Maxwell Air Force Base, Alabama June 2005 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of

Trend and outcome of Korean patients receiving overseas solid organ transplantation between 1999 and 2005.

PubMed

Kwon, Choon Hyuck David; Lee, Suk-Koo; Ha, Jongwon

2011-01-01

The disparity between patients awaiting transplantation and available organs forced many patients to go overseas to receive a transplant. Few data concerning overseas transplantation in Korea are available and the Korea Society for Transplantation conducted a survey to evaluate the trend and outcome of overseas transplantation. The survey, conducted on June 2006, included 25 hospitals nationwide that followed up patients after receiving kidney transplant (KT) or liver transplant (LT) overseas. The number of KT increased from 6 in 2001 to 206 in 2005 and for LT from 1 to 261. The information about overseas transplant came mostly from other patients (57%). The mean cost for KT was $21,000 and for LT $47,000. Patients were admitted for 18.5 days for KT and 43.4 days for LT. Graft and patient survival was 96.8% and 96.5% for KT (median follow up 23.1 months). Complication occurred in 42.5% including surgical complication (5.3%), acute rejection (9.7%) and infection (21.5%). Patient survival for LT was 91.8% (median follow up 21.2 months). Complication occurred in 44.7% including 19.4% biliary complication. Overseas KT and LT increased rapidly from 2001 to 2005. Survival of patients and grafts was comparable to domestic organ transplantation, but had a high complication rate.

Operational Leadership in Kosovo

DTIC Science & Technology

2004-02-09

ARRC) LGEN Michael Jackson Allied Air Forces North (COMAIRNORTH) GEN John Jumper Allied Naval Forces North (COMNAVNORTH) U.K. Allied Naval Forces South... Michael Jackson reportedly told the US commander (Clark) during one heated exchange. When General Jackson refused, General Clark asked Admiral James

AFRL Defensive IO Programs

DTIC Science & Technology

2002-04-22

NUMBER Air Force Research Laboratory 525 Brooks Road, Rome NY 13441 11. SUPPLEMENTARY NOTES 12a. DISTRIBUTION / AVAILABILITY STATEMENT Approved for...entire NOSC crew Air Force Enterprise Defense Moving from Data-Centric to Mission-Centric Operations 16 Summary • The AFRL /IF program includes all...William E.; Simpson, Lt. Col Richard 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Air Force

KSC-04pd1253

NASA Image and Video Library

2004-06-09

KENNEDY SPACE CENTER, FLA. - At Cape Canaveral Air Force Station, KSC Firefighter Chris Maupin (left) takes equipment from Lt. Keith Abell. They and other KSC firefighters teamed up with task forces from Satellite Beach, Malabar, Melbourne, Palm Bay, Patrick Air Force Base and Brevard County to help fight wildfires in the Palm Bay and Malabar areas that threatened homes and property during the Memorial Day holiday weekend.

An Inventory and Safety Stock Analysis of Air Force Medical Service Pharmaceuticals

DTIC Science & Technology

2015-03-26

Adam D. Reiman , PhD Member AFIT-ENS-MS-15-M-133 iv Abstract A significant challenge facing the Air Force Medical Service (AFMS...sincere gratitude to my research committee, Dr. William Cunningham and Lt Col Adam Reiman for their guidance and support throughout the research

Lonely Skies: Air-to-Air Training for a 5th Generation Fighter Force

DTIC Science & Technology

2015-06-01

Missing Attitude Indicator….…………………14 4 Lt James Doolittle during Blind Flight Test…..……………………...15 5 An Early Link Trainer Cockpit...during visual flight because it deceived pilots about the actual aircraft attitude and acceleration. 1st Lt James Doolittle used Doctor David Meyers...flying pioneer and leader, Doolittle believed that pilots should learn to ignore their physical sense of motion while flying blind and to trust their

Experimental Vibration Analysis of Inflatable Beams for an AFIT Space Shuttle Experiment

DTIC Science & Technology

2002-03-01

appreciate his efforts and wish I had listened to him. I would also like to thank Dr. Gregg Gunsch, Major Richard Cobb, Lt Col Price Smith and Lt Col...frequencies and damping ratios, a program written in MAT- LAB by then Captain Richard Cobb of the Air Force Research Laboratory[7] was used. The EZERA routine...W. and J. Penzien. Dynamics of Structures . New York: McGraw-Hill, 1975. 7. Cobb, Richard , Captain USAF. Structural Damage Identification From Limited

2014 Service Academy Gender Relations Survey: Overview Report

DTIC Science & Technology

2015-02-09

Military Academy); CDR Lyn Hammer and LT Ashley Gudknecht (U.S. Naval Academy); Dr. Amanda Lords and Lt Col Jeffrey DeMuth (U.S. Air Force Academy); and...incidence of unwanted sexual contact, sexual harassment, and related issues at the U.S. Military Academy (USMA), the U.S. Naval Academy (USNA), the U.S...surveys of the military and DoD community using these “Best Practices” for over 25 years, tailored as appropriate for the unique design needs of specific

Novel Synthesis and Characterization of Inorganic Fullerene Type WS2 and Graphene Hybrids

DTIC Science & Technology

2013-03-01

Figure 1.   Photograph of two sailors wearing a “light” version of body armor (Image used with permission from LT Melanie Chambers and LT Kathryn...protection body armor in use is a vast improvement over the animal hides and chain mail our descendants wore many years ago [1]. Today’s body armor...worn, but lowers the level of threats the body armor will be able to withstand. Often such operating environments force soldiers to choose between

Privatized Military Operations. Industry Study, Spring 2009

DTIC Science & Technology

2009-01-01

to the nation. Ms. Kathy Aydt, Dept of Army GPCAPT Rob Barnes, Royal Australian Air Force COL Michael Bird, US Army CAPT Bruce Breth, US Navy ...Force CDR Ron Foy, US Navy COL Michael Hoskin, US Army Col Doug McCarthy, Canadian Forces Lt Col William Murphey, US Air Force COL Broc Perkuchin...Wellington, New Zealand Royal New Zealand Navy Logistics, Devonport Naval Base, Auckland, New Zealand VT Fitzroy, Devonport Naval Base, Auckland, New

The Swarm, the Cloud, and the Importance of Getting There First: What’s at Stake in the Remote Aviation Culture Debate

DTIC Science & Technology

2013-08-01

following former Air Force chiefs of staff: Gen Mi- chael Ryan, Gen John Jumper, and Gen Norton Schwartz. See Boyne , “How the Predator Grew Teeth.” 14. P... John L. McLucas has written: I believe we are entering an era when RPVs [remotely piloted ve- hicles] will play an increasingly important role in...technology as an amplifier of integrated human agency; and Col John Boyd observes how our definitions of cultural membership shift over time. By way of

Effects of a New Cooling Technology on Physical Performance in U.S Air Force Military Personnel

DTIC Science & Technology

2015-03-25

AFRL-SA-WP-SR-2015-0001 Effects of a New Cooling Technology on Physical Performance in U.S. Air Force Military Personnel...Ph.D. March 2015 Air Force Research Laboratory 711th Human Performance Wing School of Aerospace Medicine Aeromedical Research...LT COL SUSAN DUKES DR. RICHARD A. HERSACK Chief, Aircrew Select & Perform Res Chair, Aeromedical

KSC-04pd1255

NASA Image and Video Library

2004-06-09

KENNEDY SPACE CENTER, FLA. - At Cape Canaveral Air Force Station, Lt. Keith Abell (left) hands equipment to KSC Firefighter Chris Maupin for storage. They and other KSC firefighters teamed up with task forces from Satellite Beach, Malabar, Melbourne, Palm Bay, Patrick Air Force Base and Brevard County to help fight wildfires in the Palm Bay and Malabar areas that threatened homes and property during the Memorial Day holiday weekend.

KSC-04pd1254

NASA Image and Video Library

2004-06-09

KENNEDY SPACE CENTER, FLA. - At Cape Canaveral Air Force Station, Lt. Keith Abell (left) and KSC Firefighter Chris Maupin store equipment on the fire truck. They and other KSC firefighters teamed up with task forces from Satellite Beach, Malabar, Melbourne, Palm Bay, Patrick Air Force Base and Brevard County to help fight wildfires in the Palm Bay and Malabar areas that threatened homes and property during the Memorial Day holiday weekend.

Nanoscale characterization and local piezoelectric properties of lead-free KNN-LT-LS thin films

NASA Astrophysics Data System (ADS)

Abazari, M.; Choi, T.; Cheong, S.-W.; Safari, A.

2010-01-01

We report the observation of domain structure and piezoelectric properties of pure and Mn-doped (K0.44,Na0.52,Li0.04)(Nb0.84,Ta0.1,Sb0.06)O3 (KNN-LT-LS) thin films on SrTiO3 substrates. It is revealed that, using piezoresponse force microscopy, ferroelectric domain structure in such 500 nm thin films comprised of primarily 180° domains. This was in accordance with the tetragonal structure of the films, confirmed by relative permittivity measurements and x-ray diffraction patterns. Effective piezoelectric coefficient (d33) of the films were calculated using piezoelectric displacement curves and shown to be ~53 pm V-1 for pure KNN-LT-LS thin films. This value is among the highest values reported for an epitaxial lead-free thin film and shows a great potential for KNN-LT-LS to serve as an alternative to PZT thin films in future applications.

Air Force Air Refueling for Naval Operations: History, Practice, and Recommendations

DTIC Science & Technology

1990-08-01

Air Force Air Refueling 0 ELECTE C4 N 910U for BU Naval Operations History, Practice, and Recommendations UtMON STA~IMENT X [ Apov.e ,opu,. Lt Col...as three hose reels provide redundancy over just one. 13. Be used in coordination with carriler -launched buddy tankers, there- by providing the

Radiation pressure excitation of Low Temperature Atomic Force & Magnetic Force Microscope (LT-AFM/MFM) for Imaging

NASA Astrophysics Data System (ADS)

Karci, Ozgur; Celik, Umit; Oral, Ahmet; NanoMagnetics Instruments Ltd. Team; Middle East Tech Univ Team

2015-03-01

We describe a novel method for excitation of Atomic Force Microscope (AFM) cantilevers by means of radiation pressure for imaging in an AFM for the first time. Piezo excitation is the most common method for cantilever excitation, but it may cause spurious resonance peaks. A fiber optic interferometer with 1310 nm laser was used both to measure the deflection of cantilever and apply a force to the cantilever in a LT-AFM/MFM from NanoMagnetics Instruments. The laser power was modulated at the cantilever`s resonance frequency by a digital Phase Lock Loop (PLL). The force exerted by the radiation pressure on a perfectly reflecting surface by a laser beam of power P is F = 2P/c. We typically modulate the laser beam by ~ 800 μW and obtain 10nm oscillation amplitude with Q ~ 8,000 at 2.5x10-4 mbar. The cantilever's stiffness can be accurately calibrated by using the radiation pressure. We have demonstrated performance of the radiation pressure excitation in AFM/MFM by imaging a hard disk sample between 4-300K and Abrikosov vortex lattice in BSCCO single crystal at 4K to for the first time.

Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery.

PubMed

Rolando, Monica; Stefani, Caroline; Doye, Anne; Acosta, Maria I; Visvikis, Orane; Yevick, Hannah G; Buchrieser, Carmen; Mettouchi, Amel; Bassereau, Patricia; Lemichez, Emmanuel

2015-10-01

It remains a challenge to decode the molecular basis of the long-term actin cytoskeleton rearrangements that are governed by the reprogramming of gene expression. Bacillus anthracis lethal toxin (LT) inhibits mitogen-activated protein kinase (MAPK) signaling, thereby modulating gene expression, with major consequences for actin cytoskeleton organization and the loss of endothelial barrier function. Using a laser ablation approach, we characterized the contractile and tensile mechanical properties of LT-induced stress fibers. These actin cables resist pulling forces that are transmitted at cell-matrix interfaces and at cell-cell discontinuous adherens junctions. We report that treating the cells with trichostatin A (TSA), a broad range inhibitor of histone deacetylases (HDACs), or with MS-275, which targets HDAC1, 2 and 3, induces stress fibers. LT decreased the cellular levels of HDAC1, 2 and 3 and reduced the global HDAC activity in the nucleus. Both the LT and TSA treatments induced Rnd3 expression, which is required for the LT-mediated induction of actin stress fibers. Furthermore, we reveal that treating the LT-intoxicated cells with garcinol, an inhibitor of histone acetyl-transferases (HATs), disrupts the stress fibers and limits the monolayer barrier dysfunctions. These data demonstrate the importance of modulating the flux of protein acetylation in order to control actin cytoskeleton organization and the endothelial cell monolayer barrier. © 2015 Wiley Periodicals, Inc.

Senior Leader Perspective on the Air Force Nuclear Enterprise: Todays Issues and the Future

DTIC Science & Technology

2016-09-15

SENIOR LEADER PERSPECTIVE ON THE AIR FORCE NUCLEAR ENTERPRISE: TODAY’S ISSUES AND THE FUTURE GRADUATE RESEARCH PAPER Matthew D. Boone...States. AFIT-ENS-MS-16-S-028 SENIOR LEADER PERSPECTIVE ON THE AIR FORCE NUCLEAR ENTERPRISE: TODAY’S ISSUES AND THE FUTURE GRADUATE... ISSUES AND THE FUTURE Matthew D. Boone, BS, MA Major, USAF Committee Membership: Robert E. Overstreet, Lt Col, USAF, PhD

Report on the 1975 Officers’ OER Opinion Survey

DTIC Science & Technology

1977-11-01

Lt Col, USAFA U PERSONNEL RESEARCH DIVISIONN Brooks Air Force Bas, Toma 73235 R Nmn*w 1977- ’ E S 033- Approval for public raaem; disubution unffn*ed...Personnel Research Division, under project 7719, with HQ Air Force Human Resources Laboratory (AFSC), Brooks Air Force Base, Texas 78235. This report...Service (NTIS). This technical report has been reviewed and is approved for publication. LELAND D. BROKAW, Technical Director Prsonnel Research

DefenseLink Special: Chairman Strives to be a 'Straight Shooter'

Science.gov Websites

from Vietnam, why, "when people were getting wounded and killed all around me, I never got a ." Marine Gen. Peter Pace, June 9, 2006 By Donna Miles / American Forces Press Service Marine Gen leader. "If you think you're a good leader, then you're probably not," Pace told American

DefenseLink Special: Travels with Pace, March 2006

Science.gov Websites

Us Travels with Pace Chairman of the Joint Chiefs of Staff Marine Gen. Peter Pace U.S. Marine Gen . Peter Pace, chairman of the Joint Chiefs of Staff, speaks to students attending the Turkish War College U.S. Air Force Staff Sgt. D. Myles Cullen Hi-Res Pace Wraps Up Visit to Allied Nations WASHINGTON

KENNEDY SPACE CENTER, FLA. - Maj. Gen. Kevin Chilton speaks to the employees and guests gathered in the KSC Training Auditorium for Spaceport Super Safety and Health Day. The kickoff presentation also included speakers Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

NASA Image and Video Library

2003-10-15

KENNEDY SPACE CENTER, FLA. - Maj. Gen. Kevin Chilton speaks to the employees and guests gathered in the KSC Training Auditorium for Spaceport Super Safety and Health Day. The kickoff presentation also included speakers Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

KENNEDY SPACE CENTER, FLA. - Employees fill the Training Auditorium for the kickoff presentation for Spaceport Super Safety and Health Day. Along with Center Director Jim Kennedy, guest speakers were Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, Maj. Gen. Kevin Chilton, and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

NASA Image and Video Library

2003-10-15

KENNEDY SPACE CENTER, FLA. - Employees fill the Training Auditorium for the kickoff presentation for Spaceport Super Safety and Health Day. Along with Center Director Jim Kennedy, guest speakers were Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, Maj. Gen. Kevin Chilton, and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

KENNEDY SPACE CENTER, FLA. - Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, speaks to the employees and guests gathered in the KSC Training Auditorium for Spaceport Super Safety and Health Day. The kickoff presentation also included speakers Maj. Gen. Kevin Chilton and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

NASA Image and Video Library

2003-10-15

KENNEDY SPACE CENTER, FLA. - Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, speaks to the employees and guests gathered in the KSC Training Auditorium for Spaceport Super Safety and Health Day. The kickoff presentation also included speakers Maj. Gen. Kevin Chilton and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

AFFTC commander Brig. Gen. Curtis Bedke experienced a Shuttle approach and landing in NASA's Shuttle Training Aircraft from STS-114 commander Eileen Collins

NASA Image and Video Library

2005-03-29

Brig. Gen. Curtis Bedke, commander of the Air Force Flight Test Center at Edwards Air Force Base, received some first-hand insight on how to fly a Space Shuttle approach and landing, courtesy of NASA astronaut and STS-114 mission commander Eileen Collins. The series of proficiency flights in NASA's modified Grumman Gulfstream-II Shuttle Training Aircraft were in preparation for the STS-114 mission with the shuttle Discovery. Although NASA's Kennedy Space Center in Florida is the primary landing site for Space Shuttle missions, flight crews also practice the shuttle's steep approach and landing at Edwards in case weather or other situations preclude a landing at the Florida site and force a diversion to Edwards AFB.

Environmental Impact Statement. Disposal and Reuse of Williams Air Force Base, Arizona.

DTIC Science & Technology

1994-06-01

none native 4. Mulberry (Moraceae op.) 5. Pine (Pinaceae up.) 6. Desert Willow (Chilopsis linearis) 7. Red Bird of Paradise (Caesalpinia pulcherrima...Cecil P. A atomne Director Laud Un Phaulfi XC Governor Thoymma 1. Whiet Lt- GOOvenr Mary T. Thomas pas DEpAWTMENT OF THE AIR FORCE wwOOS Am FORM OA5 TWax

Redefining the Air Force Medical Service in the New Millennium: Should the AFMS Outsource Physician Training and Residency Education Programs

DTIC Science & Technology

2000-04-01

Partial Fulfillment of the Graduation Requirements Advisor: Lieutenant Colonel Marshell G. Cobb Maxwell Air Force Base, Alabama April 2000 ii Disclaimer...to future commanders and medical support providers. Special thanks are in order to Lt Col Marshell Cobb for agreeing to be my faculty advisor

Space Separatism: Degree of Differentiation

DTIC Science & Technology

2014-12-01

Separate Service” (Norfolk, VA: Joint Forces Staff College, 6 September 2002); MAJ William S. Moncrief , “Building a United States Space Force,” Army Space...unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 November–December 2014 Air...FY14_Green_Book.pdf. 32. Story, “Separate Space Force,” 2–5. 33. Moncrief , “Building a United States Space Force,” 34–38. 34. DODD 3100.10, Space Policy, 3. 35. Lt

Pace Speaks Across America - February 21 2007 - U.S. Department of Defense

Science.gov Websites

Washington State, Oregon, Alaska and Florida. Pace Discusses Force Levels, Military Challenges WASHINGTON Iraq, force levels or tour lengths, Marine Gen. Peter Pace is eager to answer frankly and completely

Dynamic load indicators for take-off-landing sequence in blocks and attacks of elite female volleyball players.

PubMed

Kabaciński, Jarosław; Dworak, Lechosław Bogdan; Murawa, Michał; Rzepnicka, Agata

2016-01-01

Dynamic loads during landings determined by the ground reaction forces (GRFs) may elaborate internal loads and increase the risk of overload knee injuries as a result of performing volleyball jumps many times. The study dealt with a biomechanical assessment of dynamic load indicators in female volleyball players for the motion sequence of take-off-landing in blocks and attacks. Twelve professional female volleyball players participated in the study. Blocks and attacks were filmed by two cameras. GRFs vs. time graphs were recorded with the use of a force platform. Values of dynamic load indicators in terms of the relations of peak of vertical component of GRF, build-up index of this force (BIF), and power output (P) during landing to the vGRF, BIF and P during take-off (L/T) were calculated. The statistically significant ( p < 0.05) highest values of L/T indicators were found for back row attack spikes: 2.4 (vGRF), 12.2 (BIF) and 3.1 (P). In the case of blocks, slide attack spikes and attack line spikes, results of these variables were in range: 1.8÷2.1, 5.9÷7.6 and 2.1÷2.9, respectively. The reduction of GRFs during landings contributes to decreasing the level of the load indicators L/T which should minimize the incidence of anterior cruciate ligament and patellar tendon injuries in female volleyball players.

The Australian Medical Support Force in Rwanda.

PubMed

Ramsey, W; Bridgford, L R; Lusby, R J; Pearn, J H

In the aftermath of the Rwandan civil war, Australia's defence forces deployed a medical force to support the United Nations Assistance Mission. In this article, Wayne Ramsey, Commander of the Australian contingent, Lindsay R Bridgford, Officer Commanding Bravo Section, Robert J Lusby, Lt.-Colonel (Surgeon), Australian Medical Support Force Hospital, and John H Pearn, Colonel, and Director of Intensive Care in the Australian Medical Support Force Hospital, describe the Australian effort in the rebuilding of a shattered people and, in particular, of Kigali Central Hospital, the country's major medical facility.

Adverse event reporting in patients treated with levothyroxine: results of the pharmacovigilance task force survey of the american thyroid association, american association of clinical endocrinologists, and the endocrine society.

PubMed

Hennessey, James V; Malabanan, Alan O; Haugen, Bryan R; Levy, Elliot G

2010-01-01

To survey physicians to determine whether potency and consistency issues with levothyroxine sodium (LT4) have been resolved and to assess current experience regarding safety of substituting LT4 products. Members of the American Association of Clinical Endocrinologists, American Thyroid Association, and The Endocrine Society collaborated to create a survey instrument that would effectively sample the clinical experience of their society members and frequent prescribers of LT4. More than 18,000 e-mailed requests for information were generated, and the Web sites of each society provided links to the data collection form. The survey provided an opportunity to collect clinical observations of adverse events or product availability problems from physicians caring for patients with thyroid disease who required use of contemporary LT4 preparations. After adjustment for known reasons for unstable results from thyroid function tests, 199 reports of adverse events associated with changes in thyrotropin values were further analyzed. One hundred seventy-seven reports (88.9%) were associated with a change in the source of LT4; no change was noted in 21 (10.6%). Details regarding the circumstances of the change were provided in 167 of the 177 reports (94.4%), The reporting physicians themselves or their office staff had changed the LT4 preparation in only 1 of the 167 cases (0.6%). The remainder of changes had been made by the patient's pharmacy, either with the physician's knowledge (in 13 of 167 cases [7.8%]) or without his/her knowledge (in 153 of 167 cases [91.6%]). Fifty-four of 199 cases (27.1%) described serious adverse events; 52 of these (96.3%) were associated with a substitution of one LT4 preparation for another. The clinical use of contemporary LT4 products continues to be associated with some adverse outcomes. A small number of reports were associated with continued use of the same LT4 products. The most frequently reported adverse outcomes were associated with the approved generic substitution of LT4 products, frequently without the prescribing physician's knowledge.

Ready for TFI Prime Time? A Closer Examination of the Dual Component Commander and the Integrated Wing

DTIC Science & Technology

2015-02-17

Structure of the Air Force. "Report to the President and Congress of the United States." January 30, 2014, 2. 44 Brig Gen Timothy J. Cathcart , (Special...30, 2014, 55-59 50 This report was provided to the author by email by Brig Gen Cathcart on 3 October 2014, “Hill F-35 I-Wing Concept, Draft

Beyond the Wild Blue Yonder: Creating an Air and Space Culture in Today’s Air Force

DTIC Science & Technology

1998-04-01

Organizational Change . 2nd ed. Westport, C.T.: Praeger Publishers, 1994. Estes III, Gen Howell M. “Air Force at a Crossroad” Speech, Air Force...American Military Styles in Strategy and Analysis. Baltimore: Johns Hopkins University Press, 1989. Conner, Patrick E., and Linda K. Lake. Managing

Commanding an Air Force Squadron

DTIC Science & Technology

1993-12-01

I The M ission ...................................... 3 The People ...................................... 5 The Chain of Command...of Air Force squadron commanders. By so doing, it serves as an explanatory text to allied officers, as a model for leadership studies, and as a...personnel, meeting the chain of command above him, and understanding the role of other units on the base. The Mission Lt Col John Bell, chief of the wing

A Study of Air Force Theater-Based Contingency Contracting Training Requirements for a Power Projection Strategy

DTIC Science & Technology

1993-09-01

Garcia . 4. Duriig base exercises, we pretend to train like we fight. However, because we know that its an exercise, we tend tu just do cnougih to gLt...Tom Wartime Contingency Contracting Handbook Update, Air Force Logistics Management Center, (June 1992b). Rolando , John A. "Is There Going to be a

Biographies

Science.gov Websites

Senior Enlisted Advisor Joint Staff History Joint Staff Inspector General Joint Staff Structure Origin of J8 | Force Structure, Resources & Assessment Contact Joint Staff Senior Leaders Gen. Joseph F Biography All Joint Staff Biographies Thomas F. Carney, Vice Director for Force Structure, Resources,and

U.S. Army Special Forces Roles in Asymmetric Warfare

DTIC Science & Technology

2001-06-01

1Jonathan B . Tucker, “Asymmetric Warfare: An Emerging Threat to U.S. Security,” Forum For Applied Research and Public Policy (Monterey...8Ibid., 34. 9Tucker, 11. 10Ibid., 2. 11 Henry H . Shelton, GEN, USA, Commander in Chief, U.S. Special Operations Command...the Senate Armed Services Committee, “Military Threats and Security Challenges Through 2015,” (Washington: 3 February 2000), 3. 26GEN Henry H

Missile Defense Acquisition: Failure Is Not An Option

DTIC Science & Technology

2016-01-26

Missile Defense Acquisition: Failure is Not an Option 8 capabilities. Retired Marine General James Mattis ’ renowned quote rings true, “The enemy...american-missile-defense-why-failure-is- an-option. 18 Vago Muradian, “Interview: Gen. James Mattis , Commander, U.S. Joint Forces Command,” 23 May...2010, http://archive.defensenews.com/article/20100523/DEFFEAT03/5230301/Gen- James - Mattis . 19 Institute for Defense Analyses, p. II-3. 20 Missile

Privatized Military Operations

DTIC Science & Technology

2007-01-01

James C. Becker Jr, U.S. Marine Corps Lt Col Harry A. Berry , U.S. Air Force LTC Kenneth L. Boehme, U.S. Army Ms. Veronica R. Crutches, Department of...A. Wyche, Defense Logistics Agency Col Lawrence K. Grubbs, U.S. Air Force, PMO Faculty Col Patrick M. Shaw , U.S. Air Force, PMO Faculty LTC (P...unique services to Fortune 100 companies for whom PMO business is a minuscule portion of their annual revenue. Apart from a few dozen large, widely

Integration of a Motion Capture System into a Spacecraft Simulator for Real-Time Attitude Control

DTIC Science & Technology

2016-08-16

Attitude Control* Benjamin L. Reifler University at Buffalo, Buffalo, New York 1st Lt Dylan R. Penn Air Force Research Laboratory, Kirtland Air Force...author was an intern at the Air Force Research Laboratory ( AFRL ) Space Vehicles Directorate. 1 DISTRIBUTION A. Approved for public release: distribution...expertise on this project. I would also like to thank the AFRL Scholars program for the opportunity to participate in this research. References [1

The Effects of Student Narration in College Engineering Classes

DTIC Science & Technology

2015-01-01

93(3), 223-231. 2004. 6. Norman, G., and Schmidt, H., “Effectiveness of Problem-Based Learning Curricula: Theory, Practice and Paper Darts ...conference papers . Dr. Richard Buckley is Lt Col in the U.S. Air Force and an Assistant Professor and Senior Military Faculty at the US Air Force...journal and conference papers . Dr. Dan Jensen is a Professor of Engineering Mechanics at the U.S. Air Force Academy where he has been since 1997. He

Determination of Ammunition Training Rates for Marine Forces Study. Volume 2.

DTIC Science & Technology

1983-09-17

ARD-fl44 430 DETERMINATION OF AMMUNITION TRAINING RATES FOR MARINE i/n FORCES STUDY VOLUME 2(U) MARINE CORPS DEVELOPMENT AND EDUCATION COMMAND... STUDY - VOL II LIEUTENANT COLONEL R. J. YEOMAN C) DEPUTY CHIEF OF STAFF FOR DEVELOPMENTAL COORDINATION MY) DEVELOPMENT CENTER ’ MARINE CORPS...MARINE FORCES STUDY , DECISION S. PERFORMING ORG. REPORT NUMBER MEMORANDUM 7. AUTHOR(#) S. CONTR 4T9M GRANT NUMUER(s) M 00027- -G-0 060 LtCol R. J

Report of Investigation: The Presence of Biological and Chemical Warfare Materiel at AFMC Bases within the United States

DTIC Science & Technology

2000-06-01

knew nothing of the BW/CW work done on the base in the 40’ s and 50’ s . 461 History of the Armament Development and Test Center, Appendix B, 1 July 1970...technical report has been reviewed and is approved for publication. FOR THE DIRECTOR ALBERT S . TORdGIAN, Lt Col, US Deputy Chief, Deployment and Su...Office of History , Air Force Materiel Command Air Force Systems Command Air Force Special Weapons Center Air Force Weapons Laboratory Air Materiel

BULGARIAN COMPATIBILITY WITH NATO AIR POWER

DTIC Science & Technology

2016-02-16

speciality: Aviator-Pilot for the Air Force; Civil speciality: Engineer -Pedagogue in Electronics and Automation with Master degree in Aviation... Engineering . During 2003-2005 Lt. Colonel Rusev was a student in Bulgarian ACSC and graduated as a Master in “Command and Control of Air Force...future belonged to the airship , while French Marshal Foch thought that the aircraft could be used for sporting purposes only.1 Bulgarian generals

Training-Based Requirements for Semi-Automated Forces

DTIC Science & Technology

1999-03-01

ARI Research Note 99-18 Training-based Requirements for Semi-Automated Forces Jim Kornell Syukhtun Research, Inc. Research and Advanced Concepts ... Concepts , Inc.; Dr. Susan Fischer, of Anacapa Sciences, Inc.; and Lt. Col. Ken Bell, ret., of THETA Technologies, Inc. All conclusions and...construed) in terms of symbols and concepts , and/or the learning of procedural knowledge. • Cognitive strategies. Skills for governing thinking. This

UNITED STATES SPECIAL OPERATIONS FORCES IN AFRICA

DTIC Science & Technology

2016-02-16

AIR WAR COLLEGE AIR UNIVERSITY UNITED STATES SPECIAL OPERATIONS FORCES IN AFRICA by Keith I. Crawford, Lt Col, USAF A Research Report... Africa Command in 2007 manifested recognition that the United States has increasing strategic national interests on the continent of Africa that are...importance of airborne ISR and basing access. Introduction In February of 2007, President George W. Bush announced the creation of Africa

Acromiohumeral Distance During Neuromuscular Electrical Stimulation of the Lower Trapezius and Serratus Anterior Muscles in Healthy Participants.

PubMed

Bdaiwi, Alya H; Mackenzie, Tanya Anne; Herrington, Lee; Horsley, Ian; Cools, Ann M

2015-07-01

Compromise to the acromiohumeral distance has been reported in participants with subacromial impingement syndrome compared with healthy participants. In clinical practice, patients with subacromial shoulder impingement are given strengthening programs targeting the lower trapezius (LT) and serratus anterior (SA) muscles to increase scapular posterior tilt and upward rotation. We are the first to use neuromuscular electrical stimulation to stimulate these muscle groups and evaluate how the muscle contraction affects the acromiohumeral distance. To investigate if electrical muscle stimulation of the LT and SA muscles, both separately and simultaneously, increases the acromiohumeral distance and to identify which muscle-group contraction or combination most influences the acromiohumeral distance. Controlled laboratory study. Human performance laboratory. Twenty participants (10 men and 10 women, age = 26.9 ± 8.0 years, body mass index = 23.8) were screened. Neuromuscular electrical stimulation of the LT and SA. Ultrasound measurement of the acromiohumeral distance. Acromiohumeral distance increased during contraction via neuromuscular electrical stimulation of the LT muscle (t(19) = -3.89, P = .004), SA muscle (t(19) = -7.67, P = .001), and combined LT and SA muscles (t(19) = -5.09, P = .001). We observed no differences in the increased acromiohumeral distance among the 3 procedures (F(2,57) = 3.109, P = .08). Our results supported the hypothesis that the muscle force couple around the scapula is important in rehabilitation and scapular control and influences acromiohumeral distance.

Countering Terrorism on Military Installations

DTIC Science & Technology

1977-07-29

military forces and police agencies since 1970 uncover fanc - tional task-areas which require examinatiin subsequent to development of theory (policy...with the CinC in his office. GEN Blanchard was aware of the ’AI visit and had reqiiested this meeting. He was extremely interested and knowledgeable in...the subject of te:’rorism. He had recettly directed the Provost Marshal to prepare a paper on the subject and a command regulation. GEN Blanchard re

Retaining U.S. Air Force Pilots When the Civilian Demand for Pilots Is Growing

DTIC Science & Technology

2016-01-01

pilot retention and determine the changes in ARP and AP that could offset those effects. It also simulates the effects of eliminating AP for pilots...array of compensation policies for pilots, thereby providing the USAF with an empirically based analytical platform to determine the special and...greatly from the input and support of our project monitor, Maj Ryan Theiss, Chief, Rated Force Policy-Mobility Forces (HQ USAF/A1PPR), as well as Lt

KSC-04pd1256

NASA Image and Video Library

2004-06-09

KENNEDY SPACE CENTER, FLA. - At Cape Canaveral Air Force Station, KSC Firefighter Chris Maupin (left) watches as Lt. Keith Abell practices maneuvering apparatus on top of the firefighting vehicle with which they are able to direct the hoses to attack fires from above and below. The firefighters teamed up with task forces from Satellite Beach, Malabar, Melbourne, Palm Bay, Patrick Air Force Base and Brevard County to help fight wildfires in the Palm Bay and Malabar areas that threatened homes and property during the Memorial Day holiday weekend.

The Rise of Robots: The Military’s Use of Autonomous Lethal Force

DTIC Science & Technology

2015-02-17

AIR WAR COLLEGE AIR UNIVERSITY THE RISE OF ROBOTS: THE MILITARY’S USE OF AUTONOMOUS LETHAL FORCE by Christopher J. Spinelli, Lt Col...ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Air War ...Christopher J. Spinelli is currently an Air War College student and was the former Commander of the 445th Flight Test Squadron at Edwards Air Force Base

Military Retirement. Dream or Dilemma for Air Force Chaplains

DTIC Science & Technology

1983-02-01

DISTRIBUTION STATEMENT (of the abstract entered in Block 20, ii different Irom Report) I6. SUPPLEMENTARY NOTES 1S. KEY WORDS (Continue on reverse side...Chaplains by James W. Milisaps, Chaplain, Lt Col, USAF A RESEARCH REPORT SUBMITTED TO THE FACULTY IN FULFILLMENT OF THE RESEARCH seFo REQUIREMENT IY&’IC...TAR February 1983 IA ~.t.~ I -- w DEPARTMENT OF THE AIR FORCE MR WAR COLLEGE (ATC) MAXWELL AIR FORCE BASS, ALABAMA 26112 Office of the Dean School of

LigParGen web server: an automatic OPLS-AA parameter generator for organic ligands

PubMed Central

Dodda, Leela S.

2017-01-01

Abstract The accurate calculation of protein/nucleic acid–ligand interactions or condensed phase properties by force field-based methods require a precise description of the energetics of intermolecular interactions. Despite the progress made in force fields, small molecule parameterization remains an open problem due to the magnitude of the chemical space; the most critical issue is the estimation of a balanced set of atomic charges with the ability to reproduce experimental properties. The LigParGen web server provides an intuitive interface for generating OPLS-AA/1.14*CM1A(-LBCC) force field parameters for organic ligands, in the formats of commonly used molecular dynamics and Monte Carlo simulation packages. This server has high value for researchers interested in studying any phenomena based on intermolecular interactions with ligands via molecular mechanics simulations. It is free and open to all at jorgensenresearch.com/ligpargen, and has no login requirements. PMID:28444340

Flexible response and the INF (Intermediate-range Nuclear Force) Treaty: what next. Study project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, H.A.

1988-03-14

The prospect of the Intermediate-range Nuclear Force (INF) Treaty led the former Supreme Allied Commander, Europe, GEN Bernard Rogers, to claim that NATO would lose weapons vital to the Alliance's defense when Pershing II (PII) and Ground-Launched Cruise Missiles (GLCM) were withdrawn from Europe. Nuclear weapons and the NATO strategy of flexible response are inseparably dependent upon each other. GEN Rogers' comments focus directly on the capability which PII and GLCM provided NATO to strike Soviet territory in event of conflict and if such an escalatory step was deemed necessary. Various sources were researched to determine if the INF Treatymore » will cripple the flexible response strategy; while it should not, certain changes in NATO's approach to defense are suggested. Specifically, conventional and nuclear improvements, the latter within the terms of the INF Treaty, are suggested, as are conventional force reduction negotiations and the Europeanization of NATO.« less

Bilateral upper limb trainer with virtual reality for post-stroke rehabilitation: case series report.

PubMed

Sampson, Michael; Shau, Yio-Wha; King, Marcus James

2012-01-01

Stroke is a leading cause of disability with many survivors having upper limb (UL) hemiparesis. UL rehabilitation using bilateral exercise enhances outcomes and the Bilateral Upper Limb Trainer (BUiLT) was developed to provide symmetrical, bilateral arm exercise in a 'forced' and self-assistive manner, incorporating virtual reality (VR) to provide direction and task specificity to users as well as action observation-execution and greater motivation to exercise. The BUiLT + VR system was trialled on five post-stroke participants with UL hemiparesis: one sub-acute and four chronic. The intervention was supplied for 45 min, 4 days/week for 6 weeks. The Fugl-Meyer Upper Extremity score (FMA-UE) was used as the primary outcome measure. Secondary outcome measures used were UL isometric strength and the Intrinsic Motivation Inventory (IMI) questionnaire. The BUiLT + VR therapy increased FMA-UE scores from 1 to 5 and overall strength in the shoulder and elbow. Motivation at the end of intervention was positive. Therapy using the BUiLT + VR system is reliable, can be administered safely and has a positive trend of benefit as measured by the FMA-UE, isometric strength testing and IMI questionnaire.

Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites.

PubMed

Engene, Niclas; Rottacker, Erin C; Kaštovský, Jan; Byrum, Tara; Choi, Hyukjae; Ellisman, Mark H; Komárek, Jiří; Gerwick, William H

2012-05-01

The filamentous cyanobacterial genus Moorea gen. nov., described here under the provisions of the International Code of Botanical Nomenclature, is a cosmopolitan pan-tropical group abundant in the marine benthos. Members of the genus Moorea are photosynthetic (containing phycocyanin, phycoerythrin, allophycocyanin and chlorophyll a), but non-diazotrophic (lack heterocysts and nitrogenase reductase genes). The cells (discoid and 25-80 µm wide) are arranged in long filaments (<10 cm in length) and often form extensive mats or blooms in shallow water. The cells are surrounded by thick polysaccharide sheaths covered by a rich diversity of heterotrophic micro-organisms. A distinctive character of this genus is its extraordinarily rich production of bioactive secondary metabolites. This is matched by genomes rich in polyketide synthase and non-ribosomal peptide synthetase biosynthetic genes which are dedicated to secondary metabolism. The encoded natural products are sometimes responsible for harmful algae blooms and, due to morphological resemblance to the genus Lyngbya, this group has often been incorrectly cited in the literature. We here describe two species of the genus Moorea: Moorea producens sp. nov. (type species of the genus) with 3L(T) as the nomenclature type, and Moorea bouillonii comb. nov. with PNG5-198(R) as the nomenclature type.

JPRS Report, East Asia Southeast Asia

DTIC Science & Technology

1991-03-07

Ko , an MP from Sagaing Division said Aung San Suu Kyi had earlier told the NLD’s Central Executive Committee to "do whatever is necessary to carry...crackdown on Mandalay’s monks who were refusing to minister Buddhist rituals to military personnel. Dozens of NLD MPs were jailed. Maung Ko , an...operating procedure signed between AFP [Armed Forces of the Philippines] chief of staff, Gen. Renato S. de Villa and Maj. Gen. Cesar P. Nazareno, PNP

Institutional Memory and the US Air Force

DTIC Science & Technology

2016-01-01

38 | Air & Space Power Journal Institutional Memory and the US Air Force Lt Col Daniel J. Brown, USAF Disclaimer: The views and opinions expressed...national defense. After each ad- vance is tested in combat, a new round of intellectual sparring commences regarding Summer 2016 | 39 Institutional Memory ...the service’s institutional memory of how it fights and what it fights with—the ways and means of war fighting. Critical to maintaining its

Evolving Intelligence, Surveillance & Reconnaissance (ISR) for Air Force Cyber Defense

DTIC Science & Technology

2013-02-14

Telecommunications and Assessment Program ( TMAP ) notes in Air Force Instruction (AFI) 10-712 that “adversaries can easily monitor (unclassified) systems to...Instruction (AFI) 10-712, Telecommunications Monitoring And Assessment Program ( TMAP ), 2011, 4. 23. Lt Col Hugh M. Ragland., interview with author...Monitoring And Assessment Program ( TMAP ), 8 June 2011. Brenner, Carl N. Col, USAF. NASIC Air & Cyber Analysis Group/CC. Interview by the author. 29

Land Combat Systems Industry

DTIC Science & Technology

2007-01-01

William Cole, US Army BG Mohammad Farghal, Jordanian Army Mr. Ron Foskey, Department of the Air Force Col John Gilmour, US Air Force LtCol Robert Glover ...Although Secretary of Defense Donald Rumsfeld had in effect, sounded the death knell for the LCS main battle tank segment with his aggressive...News, April 24, 2007. Retrieved on April 25, 2007 from http://www.defensenews.com/ story.php?F=2709564&C= america 47 There are many other

Air Force Academy Aeronautics Digest.

DTIC Science & Technology

1984-03-01

Farren, Glauert, R. H. Fowler , George Thomson, E . D. Adrian and Melvill Jones were certainly "Chudleighites." When I arrived at Farnborough I was put to... E . McCann, Lt. Colonel, USAF Director of Research, Studies, and Analysis UNCLASSIFIED SECURITY CLASSIFICATION OF TIlS PAGE REPORT DOCUMENTATION PAGE...NOS P ROGRAM PROJECT TASK WORK UNIT E LE MENT NO. NO. NO. NO * 11 TITLE fInclude Secuity Clawiaiciceton) Air Force Academy Aeronautics Digest

Isometric muscle activation of the serratus anterior and trapezius muscles varies by arm position: a pilot study with healthy volunteers with implications for rehabilitation.

PubMed

Miyasaka, Junsuke; Arai, Ryuzo; Ito, Taisuke; Shingu, Nobuyuki; Hasegawa, Satoshi; Ibuki, Satoko; Ichihashi, Noriaki; Matsuda, Shuichi; Moritani, Toshio

2017-07-01

This study aimed to determine the most appropriate angle and moving direction of the arm for improving coordination of the periscapular muscles, including the serratus anterior (SA), upper trapezius (UT), middle trapezius (MT), and lower trapezius (LT). Muscle activation amplitudes were evaluated in the SA, UT, MT, and LT in 11 healthy subjects by use of surface electromyography. The subjects were asked to maintain the arm position at 5 elevated positions with maximal effort against applied manual forces, which were directed from upper to lower (test 1), lower to upper (test 2), posterior to anterior in the frontal plane and lateral to medial in the sagittal plane (test 3), and anterior to posterior in the frontal plane and medial to lateral in the sagittal plane (test 4). The relative activity of the UT with respect to the SA, MT, and LT was calculated, resulting in the UT/SA, UT/MT, and UT/LT ratios. Test 4 in all positions but 150° of elevation in the frontal plane showed high activity of the SA with a low UT/SA ratio. High MT activity with a low UT/MT ratio was observed during test 3 at the 90° elevated position, whereas high LT activity without UT hyperactivation was not found. To strengthen the periscapular muscles in the balanced condition, horizontal adduction is recommended for the SA. Horizontal abduction at the 90° elevated position should be effective for the MT. Because no technique in this study was effective for the LT, further studies are needed. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Faster Movement Speed Results in Greater Tendon Strain during the Loaded Squat Exercise

PubMed Central

Earp, Jacob E.; Newton, Robert U.; Cormie, Prue; Blazevich, Anthony J.

2016-01-01

Introduction: Tendon dynamics influence movement performance and provide the stimulus for long-term tendon adaptation. As tendon strain increases with load magnitude and decreases with loading rate, changes in movement speed during exercise should influence tendon strain. Methods: Ten resistance-trained men [squat one repetition maximum (1RM) to body mass ratio: 1.65 ± 0.12] performed parallel-depth back squat lifts with 60% of 1RM load at three different speeds: slow fixed-tempo (TS: 2-s eccentric, 1-s pause, 2-s concentric), volitional-speed without a pause (VS) and maximum-speed jump (JS). In each condition joint kinetics, quadriceps tendon length (LT), patellar tendon force (FT), and rate of force development (RFDT) were estimated using integrated ultrasonography, motion-capture, and force platform recordings. Results: Peak LT, FT, and RFDT were greater in JS than TS (p < 0.05), however no differences were observed between VS and TS. Thus, moving at faster speeds resulted in both greater tendon stress and strain despite an increased RFDT, as would be predicted of an elastic, but not a viscous, structure. Temporal comparisons showed that LT was greater in TS than JS during the early eccentric phase (10–14% movement duration) where peak RFDT occurred, demonstrating that the tendon's viscous properties predominated during initial eccentric loading. However, during the concentric phase (61–70 and 76–83% movement duration) differing FT and similar RFDT between conditions allowed for the tendon's elastic properties to predominate such that peak tendon strain was greater in JS than TS. Conclusions: Based on our current understanding, there may be an additional mechanical stimulus for tendon adaptation when performing large range-of-motion isoinertial exercises at faster movement speeds. PMID:27630574

Project AIR FORCE Modeling Capabilities for Support of Combat Operations in Denied Environments

DTIC Science & Technology

2015-01-01

within the Air Force and OSD.7 First, we thank Generals Herbert Carlisle, PACAF/CC, and Janet Wolfenbarger, AFMC/CC, for sponsoring this work. Gen...March 2014: http://www.rand.org/pubs/monographs/MG176.html Stucker, James P., Ruth T. Berg, Andre A. Gerner, Amada Giarla, William L. Spencer

Air and Space Power Journal. Volume 30, Number 3, Fall 2016

DTIC Science & Technology

2016-01-01

smarter ways to do business. —Gen Larry Spencer Former Air Force Vice-Chief of Staff General Spencer’s call to managerial arms is certainly one that our...weaknesses exploitable by an enemy. 20. James G. March and Herbert A. Simon, Organizations (New York: John Wiley and Sons, 1958), 140, 146. 21. Graham T...eight years,” said Gen Herbert “Hawk” Carlisle during a September 2015 talk at the Center for Strategic and International Studies in Washington

Black Hats and White Hats: The Effect of Organizational Culture and Institutional Identity on the Twenty-third Air Force

DTIC Science & Technology

2006-12-01

comments, and insight. Finally, I must offer a special thank-you to Gen Norton Schwartz; Brig Gen Eric Fiel; Col Tracy “Moose” Amos; Col Dennis...the two communities, their institutional histories have played a significant role in their organizational development. According to Col Ken Pribyla...Low IIIs, UH-60 Blackhawks (the Army’s first operational company of UH-60s), CH-47C Chi- nooks from the 101st Airborne Division, and OH-6 Loach

AIR FORCE CYBER MISSION ASSURANCE SOURCES OF MISSION UNCERTAINTY

DTIC Science & Technology

2017-04-06

Army’s Command and General Staff College at Fort Leavenworth, Kansas. Lt Col Herwick holds a bachelor of science degree in Computer Science from the...United States Air Force Academy and a master’s degree in Computer Resources and Information Management from Webster University. iii Abstract...vocabulary and while it is common to use conversationally, that usage is not always based on specific definitions. As a result, it finds common usage in

Understrength Air Force Officer Career Fields. A Force Management Approach

DTIC Science & Technology

2005-01-01

LtCol John Crown (DPSA). In addition, we had very helpful interviews with Mr. Vaughan Blackstone (DPAPP) and Mr. Dennis Miller (DPPAO). Also at...econometric impact analysis that was used to determine an optimal bonus amount or target population prior to bonus implementation.15 The success of...problems in managing personnel assignments. First, there is a high " tax " for special-duty jobs that requires them to place personnel officers into

Diesel Engine Technology Update

DTIC Science & Technology

1987-07-01

AFWAL-TR-87-20 54 83-021-DET DIESEL ENGINE TECHNOLOGY UPDATE Kaupert, Andrew W., Lt. Col. USAFR Air Force Reserves Detroit Detachment 2 Ann Arbor, MI...sponsored adiabatic turbocompound diesel engine . One goal was the use of no water or air cooling for the engine to enable the minimized heat transfer from...sector with severe • impact on the stationary engine segment of the marketplace. The effect of this proposed legislation on Air Force fuel quality is

Defense Science Board Summer Study on Transformation: A Progress Assessment. Volume 1

DTIC Science & Technology

2006-02-01

Force Chairmen. Dr. Jerry McGinn, OUSD(P), will serve as the Executive Secretary, and Lt Col Dave Robertson will serve as the Defense Science Board...Sweetzer United States Army Operational Assessment 2005 Col Gail Wojtowicz United States Air Force USAF Brief on Transformation Col Peter Zielinski ...JOC) COL Peter Zielinski CENTCOM Central Command C-10 DSB 2005 SUMMER STUDY ON APPENDICES MULTI-AGENCY INTEGRATION MG Herbert Altshuler Commander

Application of a laser trap as a viscometer

NASA Astrophysics Data System (ADS)

Cooper, James; Solomon, Rance; Elrod, Samuel; Barnes, Taylor; Crawford, Cameron; Farone, Anthony; Farone, Mary; Erenso, Daniel

2013-06-01

A laser tweezer (LT) along with advanced imaging techniques has been widely applied to manipulate and study living as well as nonliving microscopic objects. In this study we present yet another novel application of LTs for a precise measurement of the viscosities of fluids in a micro-volume flow. We have demonstrated this novel application by measuring the viscosity of a fetal bovine serum (FBS) using a LT constructed from a single intensity gradient laser trap. By calibrating the LT using dielectric silica micro-beads in a fluid with a known viscosity, specifically water, and by suspending same size of silica beads in the FBS and trapping with the same trap, we have determined the viscosity of the FBS at different temperatures. We have used the relationship between the trapping and Stoke's drag force for a constant drag speed to determine the viscosity. We have also analyzed the viscosities determined in comparison with corresponding viscosities measured using an Ostwald viscometer.

Effects of dietary ramie powder at various levels on carcass traits and meat quality in finishing pigs.

PubMed

Li, Yinghui; Liu, Yingying; Li, Fengna; Lin, Qian; Dai, Qiuzhong; Sun, Jianbang; Huang, Xingguo; Chen, Xiao'an; Yin, Yulong

2018-04-21

This study investigated the effects of ramie (0, 3, 6, 9, or 12%) included in finishing diets on carcass traits and meat quality of Xiangcun black pigs. Results showed that ramie decreased (linear, P < .05) backfat depth while it increased (linear, P < .05) loin-eye area. A quadratic effect of shear force in longissimus thoracis (LT) was observed, and the lowest value was noted in the 6% ramie group. Protein content in LT was linearly increased by ramie (linear, P < .01). Meanwhile, dietary ramie linearly decreased lipogenic genes mRNA levels and fiber cross-sectional area, but it linearly increased total fiber number of LT. These results suggest that ramie included in the diet <9% is an effective feed crop to partly improve carcass trait and muscle chemical composition without negatively affecting growth performance, and the underlying mechanism may be due to the changed lipogenic potential and myofiber characteristics induced by ramie. Copyright © 2018. Published by Elsevier Ltd.

Aging implications on fresh muscle traits of Certified Angus Beef steaks.

PubMed

Adcock, L A; Sawyer, J T; Lambert, B D; Jones, T N; Ball, J J; Wyatt, R P; Jackson, J

2015-12-01

Vacuum-packaged Certified Angus Beef (CAB) subprimals ( = 72) that included the longissimus thoracis (LT), longissimus lumborum (LL), gluteus medius (GM), and infraspinatus (IF) muscles were purchased from a major beef packing facility. Subprimals were allocated to 1 of 3 aging periods (14, 28, or 42 d) and aged at 2°C. After aging, 5 steaks were cut from each subprimal and assigned to pH, water-holding capacity, Warner-Bratzler shear force (WBSF), cooked color, cooking yield, cooking loss, and sensory panel analysis. Infraspinatus steaks were more tender ( < 0.05) than all other steaks, and subprimals aged 14 d had greater ( < 0.05) WBSF values than the other 2 aging periods, regardless of muscle. Water-holding capacity and cook yield were greater ( < 0.05) for LL and LT than IF and GM steaks, whereas purge loss was greater ( < 0.05) for IF and GM than LL and LT steaks. Throughout the aging periods, pH declined for all muscle groups, with IF steaks having the greatest ( < 0.05) pH values among all muscles. Among IF steaks, sensory evaluations of all attributes did not ( ≥ 0.26) differ across aging periods; yet among LT steaks, consumers rated those aged 14 d greater ( < 0.05) in overall impression than LT steaks aged 28 and 42 d. Among LT steaks, those aged 14 d received greater ( < 0.05) flavor ratings than LT steaks subjected to longer aging periods, and LT steaks aged 14 d received the greatest ( < 0.05) overall impression, with consumers giving greater ( < 0.05) overall impression scores to LT steaks aged 42 d over those aged 28 d. Aging period had no effect ( ≥ 0.017) on consumer ratings for flavor, tenderness, juiciness, or overall impression of LL steaks. Among GM steaks, consumers rated steaks aged 14 and 28 d more ( < 0.05) flavorful than those aged 42 d, and consumer ratings for overall impression were greater ( < 0.05) for GM steaks aged 28 d than for GM steaks aged 42 d; however, consumers failed ( = 0.035) to note differences in tenderness scores of GM steaks in response to aging period. Furthermore, consumers indicated a greater ( < 0.05) likelihood to purchase LT steaks aged 14 d over LT steaks aged 28 d, LL steaks aged 42 d over LL steaks aged 14 d, and GM steaks aged 14 and 28 d over GM steaks aged 42 d. These results indicate that consumers struggled to identify steak flavor attributes and suggest that the benefit of aging for premium beef products does not offer a tremendous sensory advantage to the consumer.

Pacific Air Forces > Home

Science.gov Websites

headquarters staff at Joint Base Pearl Harbor-Hickam, Hawaii, May 16, 2016. U.S. Air Force Maj. Gen. Russell L Tarin Punsri (center left), and attendees pose for a photo in the Courtyard of Heroes at Joint Base commander's call at Misawa Air Base, Japan, May 11, 2018. The general highlighted the strategic importance of

NATO Enlargement--Round Two; Prudence or Folly?

DTIC Science & Technology

1999-04-01

about the 60% level . See Golden, 28, and Binnendijk, 56. 34 This figure was based on results of a ground analysis performed by SHAPE which estimated... A Research Report Submitted to the Faculty In Partial Fulfillment of the Graduation Requirements Advisor: Lt Col Charles E. Costanzo Maxwell Air Force...foreign and defense policies, but could also have a very real and personal impact on me as an Air Force officer. As a result, when the opportunity arose

Physical Fitness Testing by the U.S. Air Force Academy, 1955-1981

DTIC Science & Technology

1983-09-01

numerous knee and back injuries were incurred during 5BX testing causing the loss of productive man-hours. In one of Lt Colonel Cooper’s original...the test items will be changed periodically to prevent prospective candidates for admis- sion to the United States Air Force Academy from practic- ing...following text, reproduced in whole, is a careful consideration of all available PAE research through 1971. Its existence should prevent unnecessary

Communicating Why: Aligning the Air Force Message

DTIC Science & Technology

2015-02-17

innovation as the Air Force’s HOW, after all the service could not have demonstrated its WHY without it. For example, Lt Col Jimmy Doolittle ...the Doolittle Raid.54 Later in the war, General Doolittle’s first order as the newly appointed commander of the 8th Air Force was to free the...fighters from their strict bomber tether so they could go on the offensive against the German fighters.55 As Doolittle later noted, the German General of

Organizing for the Future: Aligning U.S. Air Force Cyber Support with Mission Assurance

DTIC Science & Technology

2011-12-01

Graduation Requirements Advisor: Lt Col John W. Matus, USAF Maxwell AFB, AL December 2011 DISTRIBUTION A. Approved for public release...14 October 2011, 13. 2 Walter J. Boyne , Beyond the Wild Blue (New York, NY: St. Martin’s Press, 1997), 22. 3 Daniel T. Kuehl, “From Cyberspace to...Organization and Command, 14 October 2011. Air Force Doctrine Document 3-12. Cyberspace Operations, 15 July 2010. Boyne , Walter J. Beyond the Wild

The Joint Chiefs of Staff Video Collections

Science.gov Websites

Senior Enlisted Advisor Joint Staff History Joint Staff Inspector General Joint Staff Structure Origin of J8 | Force Structure, Resources & Assessment Contact Home : Media : Videos Featured Videos Gen

[Lung transplantation in pulmonary fibrosis and other interstitial lung diseases].

PubMed

Berastegui, Cristina; Monforte, Victor; Bravo, Carlos; Sole, Joan; Gavalda, Joan; Tenório, Luis; Villar, Ana; Rochera, M Isabel; Canela, Mercè; Morell, Ferran; Roman, Antonio

2014-09-15

Interstitial lung disease (ILD) is the second indication for lung transplantation (LT) after emphysema. The aim of this study is to review the results of LT for ILD in Hospital Vall d'Hebron (Barcelona, Spain). We retrospectively studied 150 patients, 87 (58%) men, mean age 48 (r: 20-67) years between August 1990 and January 2010. One hundred and four (69%) were single lung transplants (SLT) and 46 (31%) bilateral-lung transplants (BLT). The postoperative diagnoses were: 94 (63%) usual interstitial pneumonia, 23 (15%) nonspecific interstitial pneumonia, 11 (7%) unclassifiable interstitial pneumonia and 15% miscellaneous. We describe the functional results, complications and survival. The actuarial survival was 87, 70 and 53% at one, 3 and 5 years respectively. The most frequent causes of death included early graft dysfunction and development of chronic rejection in the form of bronchiolitis obliterans (BOS). The mean postoperative increase in forced vital capacity and forced expiratory volume in the first second (FEV1) was similar in SLT and BLT. The best FEV1 was reached after 10 (r: 1-36) months. Sixteen percent of patients returned to work. At some point during the evolution, proven acute rejection was diagnosed histologically in 53 (35%) patients. The prevalence of BOS among survivors was 20% per year, 45% at 3 years and 63% at 5 years. LT is the best treatment option currently available for ILD, in which medical treatment has failed. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

Energetic Azido Compounds

DTIC Science & Technology

1980-03-28

Dr. F. Roberto Lt. S. Clift Naval Weapons Center 3 Mr. ;. Geisler Chi•a Lakre, CA 93555 4a Attn: Dr. A. Amsrer, Code 385 U.S. Army Research Office I...Research Naval: Weapons Center 1 Directorate of Chemical Sciences China Lake, CA 93555 Bolling Air Force Base Attn: Mr. H. Richter, Code 3858

Are Marines a Better Fit for Afghanistan

DTIC Science & Technology

2008-03-01

FOR AFGHANISTAN? by Lieutenant Colonel William M. Tart Unites States Air Force Colonel John A. Terrell Project Adviser This SRP is submitted in...December 2007. 7 Telephone interview with Lt Col James Kendall, USMC, USMC PP&O, 11 Jan 08. 8 Anne Flaherty, “Marine Commandant Says He Is Concerned Iraq

U.S. Air Force Application of a U.S. Army Transportation Capability Assessment Methodology.

DTIC Science & Technology

1987-09-01

Management Command Transportation Engineering Agency, Newport News VA, July 1986. 22. Lambert, Douglas M. and James R. Stock. Strategic Physical...Distribution Management. Homewood IL: Richard D. Irwin, Inc., 1982. 23. Mabe , Capt Richard D. and Lt Col Paul A. Reid. Syllabus and Notetaking Package LOG

The Benefits Aviation Psychologists Offer Operational Commanders: An Analysis and Discussion

DTIC Science & Technology

2002-04-01

Advisor: Lieutenant Colonel Marshell G. Cobb, USAF Maxwell Air Force Base, Alabama April 2001 Report Documentation Page Report Date 01APR2002...Lt. Col. Marshell Cobb and Ann Huffman of the United States Army Europe Medical Research Unit. Without their help this project would clearly not

Using Nanotechnology to Detect Nerve Agents

DTIC Science & Technology

2011-01-01

56 | Air & Space Power Journal Air Force Institute of Technology Using Nanotechnology to Detect Nerve Agents Lt Col Mark N. Goltz , PhD, USAF...Retired Dr. Dong Shik Kim Maj LeeAnn Racz, PhD, USAF* *Lieutenant Colonel Goltz and Major Racz are faculty members in the Department of Systems and

Selection of UV Resins for Nanostructured Molds for Thermal-NIL.

PubMed

Jia, Zheng; Choi, Junseo; Park, Sunggook

2018-06-18

Nanoimprint molds made of soft polymeric materials have advantages of low demolding force and low fabrication cost over Si or metal-based hard molds. However, such advantages are often sacrificed by their reduced replication fidelity associated with the low mechanical strength. In this paper, we studied replication fidelity of different UV-resin molds copied from a Si master mold via UV nanoimprint lithography (NIL) and their thermal imprinting performance into a thermoplastic polymer. Four different UV resins were studied: two were high surface energy UV resins based on tripropyleneglycol diacrylate (TPGDA resin) and polypropyleneglycol diacrylate (PPGDA resin), and the other two were commercially available, low surface energy poly-urethane acrylate (PUA resin) and fluorine-containing (MD 700) UV resins. The replication fidelity among the four UV-resins during UV nanoimprint lithograph from a Si master with sharp nanostructures was in the increasing order of (poorest) PUA resin < MD 700 < PPGDA resin < TPGDA resin (best). The results show that the high surface energy and small monomer size are keys to achieving good UV resin filling into sharp nanostructures over the viscosity of the resin solution. When the four UV-resin molds were used for thermal-NIL into a thermoplastic polymer, the replication fidelity was in the increasing order of (poorest) MD 700 < TPGDA resin < PUA resin (best), which follows the same order of their Young's moduli. Our results indicate that the selection of an appropriate UV resin for NIL molds requires consideration of the replication fidelities in the mold fabrication and the subsequent thermal-NIL into thermoplastic polymers. © 2018 IOP Publishing Ltd.

High early cardiovascular mortality following liver transplantation

PubMed Central

VanWagner, Lisa B.; Lapin, Brittany; Levitsky, Josh; Wilkins, John T.; Abecassis, Michael M.; Skaro, Anton I.; Lloyd-Jones, Donald M.

2014-01-01

Cardiovascular disease (CVD) contributes to excess long-term mortality after liver transplantation (LT), however little is known about early post-operative CVD mortality in the current era. In addition, there is no model to predict early post-operative CVD mortality across centers. We analyzed adult recipients of primary LT in the Organ Procurement and Transplantation Network (OPTN) database between February 2002 and December 2012 to assess prevalence and predictors of early (30-day) CVD mortality, defined as death from arrhythmia, heart failure, myocardial infarction, cardiac arrest, thromboembolism, and/or stroke. We performed logistic regression with stepwise selection to develop a predictive model of early CVD mortality. Sex and center volume were forced into the final model, which was validated using bootstrapping techniques. Among 54,697 LT recipients, there were 1576 (2.9%) deaths within 30 days. CVD death was the leading cause of 30-day mortality (42.1%), followed by infection (27.9%) and graft failure (12.2%). In multivariate analysis, 9 (6 recipient, 2 donor, 1 operative) significant covariates were identified: age, pre-operative hospitalization, ICU and ventilator status, calculated MELD score, portal vein thrombosis, national organ sharing, donor BMI and cold ischemia time. The model showed moderate discrimination (c-statistic 0.66, 95% CI: 0.63–0.68). We provide the first multicenter prognostic model for the prediction of early post-LT CVD death, the most common cause of early post-LT mortality in the current transplant era. However, evaluation of additional CVD-related variables not collected by the OPTN are needed in order to improve model accuracy and potential clinical utility. PMID:25044256

Modeling winter precipitation over the Juneau Icefield, Alaska, using a linear model of orographic precipitation

NASA Astrophysics Data System (ADS)

Roth, Aurora; Hock, Regine; Schuler, Thomas V.; Bieniek, Peter A.; Pelto, Mauri; Aschwanden, Andy

2018-03-01

Assessing and modeling precipitation in mountainous areas remains a major challenge in glacier mass balance modeling. Observations are typically scarce and reanalysis data and similar climate products are too coarse to accurately capture orographic effects. Here we use the linear theory of orographic precipitation model (LT model) to downscale winter precipitation from a regional climate model over the Juneau Icefield, one of the largest ice masses in North America (>4000 km2), for the period 1979-2013. The LT model is physically-based yet computationally efficient, combining airflow dynamics and simple cloud microphysics. The resulting 1 km resolution precipitation fields show substantially reduced precipitation on the northeastern portion of the icefield compared to the southwestern side, a pattern that is not well captured in the coarse resolution (20 km) WRF data. Net snow accumulation derived from the LT model precipitation agrees well with point observations across the icefield. To investigate the robustness of the LT model results, we perform a series of sensitivity experiments varying hydrometeor fall speeds, the horizontal resolution of the underlying grid, and the source of the meteorological forcing data. The resulting normalized spatial precipitation pattern is similar for all sensitivity experiments, but local precipitation amounts vary strongly, with greatest sensitivity to variations in snow fall speed. Results indicate that the LT model has great potential to provide improved spatial patterns of winter precipitation for glacier mass balance modeling purposes in complex terrain, but ground observations are necessary to constrain model parameters to match total amounts.

Acromiohumeral Distance During Neuromuscular Electrical Stimulation of the Lower Trapezius and Serratus Anterior Muscles in Healthy Participants

PubMed Central

Bdaiwi, Alya H.; Mackenzie, Tanya Anne; Herrington, Lee; Horsley, Ian; Cools, Ann M.

2015-01-01

Context Compromise to the acromiohumeral distance has been reported in participants with subacromial impingement syndrome compared with healthy participants. In clinical practice, patients with subacromial shoulder impingement are given strengthening programs targeting the lower trapezius (LT) and serratus anterior (SA) muscles to increase scapular posterior tilt and upward rotation. We are the first to use neuromuscular electrical stimulation to stimulate these muscle groups and evaluate how the muscle contraction affects the acromiohumeral distance. Objective To investigate if electrical muscle stimulation of the LT and SA muscles, both separately and simultaneously, increases the acromiohumeral distance and to identify which muscle-group contraction or combination most influences the acromiohumeral distance. Design Controlled laboratory study. Setting Human performance laboratory. Patients or Other Participants Twenty participants (10 men and 10 women, age = 26.9 ± 8.0 years, body mass index = 23.8) were screened. Intervention(s) Neuromuscular electrical stimulation of the LT and SA. Main Outcome Measure(s) Ultrasound measurement of the acromiohumeral distance. Results Acromiohumeral distance increased during contraction via neuromuscular electrical stimulation of the LT muscle (t19 = −3.89, P = .004), SA muscle (t19 = −7.67, P = .001), and combined LT and SA muscles (t19 = −5.09, P = .001). We observed no differences in the increased acromiohumeral distance among the 3 procedures (F2,57 = 3.109, P = .08). Conclusions Our results supported the hypothesis that the muscle force couple around the scapula is important in rehabilitation and scapular control and influences acromiohumeral distance. PMID:25933249

KSC-LOC-63P-0151

NASA Image and Video Library

1963-11-16

CAPE CANAVERAL Fla. -- Maj. Gen. L. I. Davis, commander of the U.S. Air Force Missile Test Center, welcomes President John F. Kennedy to the Cape Canaveral Missile Test Annex in Florida. Photo Credit: NASA

Mobilization: Preparedness, Manpower, Industrial. A Selective Bibliography, 1918-1979

DTIC Science & Technology

1980-07-01

Affetting the Strengthening of the U.S. Army." Paul. H. Nitze. Armor 70: 9-11, November-December 1961 y "The ^l^l^^Ai^Delense." Gen. Maxwell D. Taylor ...Air De- - fense. 8: 61-69, Spring 1956 "The Facts Bear Out Taylor , Army Chief Says We’re Not Ready for Any War." John Wiant. Army Navy Air Force...Summer 1957 "Improving Our Capabilities for Limited War." Gen. Maxwell D. Taylor . Army Information Digest 14: 2-9, February 1959; Armor 68; 22-23

Air Force Combat Wings: Lineage and Honors Histories, 1947-1977

DTIC Science & Technology

1984-06-01

bendwise. 1949-30 Apr 195. Group. 22d: 1 Aug Motto: FORTITUDO ET PRE - 1948-16 Jun 1952 (detached 1 Aug 41 71. 777.- - - COMBAT WINGS 1948-30 Jun 1949, 14...all within ; 1973; 0-2, 1971-; A-7, 1972-. diminished b,’rdure of the last. MGtto: Operutions. Served in the defense of LOS PROFESIONALES -The profes...S 13 Jul 1959; Col Samuel Gy. Porterfield, 20 Aug 1959; Maj Gen Jol-ph J. Pres - ’’"T ton, 12 Oct 1959; Brig Gen William E. Creer, 28 Sep 1960; Brig

Reducing the Gap of Pain: A Strategy for Optimizing Federal Resource Availability in Response to Major Incidents

DTIC Science & Technology

2007-03-01

TM Transportation Means TX- TF1 Texas Task Force 1; a US&R team UPS United Parcel Service, Inc.; a major commercial cargo carrier US&R Urban...Pennsylvania Urban Search and Rescue (US&R) Task Force One (PA- TF1 ) were pre-deployed to the area in advance of the storm. In a moving report of their...4 it would be a good idea to add swiftwater/flood rescue components to all of the US&R Task Forces.” Lt. Douglas Bair, a PA- TF1 rescue squad

Phylogenomic Study of Burkholderia glathei-like Organisms, Proposal of 13 Novel Burkholderia Species and Emended Descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae

PubMed Central

Peeters, Charlotte; Meier-Kolthoff, Jan P.; Verheyde, Bart; De Brandt, Evie; Cooper, Vaughn S.; Vandamme, Peter

2016-01-01

Partial gyrB gene sequence analysis of 17 isolates from human and environmental sources revealed 13 clusters of strains and identified them as Burkholderia glathei clade (BGC) bacteria. The taxonomic status of these clusters was examined by whole-genome sequence analysis, determination of the G+C content, whole-cell fatty acid analysis and biochemical characterization. The whole-genome sequence-based phylogeny was assessed using the Genome Blast Distance Phylogeny (GBDP) method and an extended multilocus sequence analysis (MLSA) approach. The results demonstrated that these 17 BGC isolates represented 13 novel Burkholderia species that could be distinguished by both genotypic and phenotypic characteristics. BGC strains exhibited a broad metabolic versatility and developed beneficial, symbiotic, and pathogenic interactions with different hosts. Our data also confirmed that there is no phylogenetic subdivision in the genus Burkholderia that distinguishes beneficial from pathogenic strains. We therefore propose to formally classify the 13 novel BGC Burkholderia species as Burkholderia arvi sp. nov. (type strain LMG 29317T = CCUG 68412T), Burkholderia hypogeia sp. nov. (type strain LMG 29322T = CCUG 68407T), Burkholderia ptereochthonis sp. nov. (type strain LMG 29326T = CCUG 68403T), Burkholderia glebae sp. nov. (type strain LMG 29325T = CCUG 68404T), Burkholderia pedi sp. nov. (type strain LMG 29323T = CCUG 68406T), Burkholderia arationis sp. nov. (type strain LMG 29324T = CCUG 68405T), Burkholderia fortuita sp. nov. (type strain LMG 29320T = CCUG 68409T), Burkholderia temeraria sp. nov. (type strain LMG 29319T = CCUG 68410T), Burkholderia calidae sp. nov. (type strain LMG 29321T = CCUG 68408T), Burkholderia concitans sp. nov. (type strain LMG 29315T = CCUG 68414T), Burkholderia turbans sp. nov. (type strain LMG 29316T = CCUG 68413T), Burkholderia catudaia sp. nov. (type strain LMG 29318T = CCUG 68411T) and Burkholderia peredens sp. nov. (type strain LMG 29314T = CCUG 68415T). Furthermore, we present emended descriptions of the species Burkholderia sordidicola, Burkholderia zhejiangensis and Burkholderia grimmiae. The GenBank/EMBL/DDBJ accession numbers for the 16S rRNA and gyrB gene sequences determined in this study are LT158612-LT158624 and LT158625-LT158641, respectively. PMID:27375597

Finding the Enemy: Using 3-D Laser Radar (LADAR) Imaging for Real Time Combat Identification of Ground Targets in an Obscured Environment

DTIC Science & Technology

2010-04-01

AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY FINDING THE ENEMY: USING 3-D LASER RADAR (LADAR) IMAGING FOR REAL TIME COMBAT...Faculty In Partial Fulfillment of Graduation Requirements Advisor: Lt Col Terry Bullard Maxwell Air Force Base, Alabama April 2010...position of the US government or the Department of Defense. In accordance with Air Force Instruction 51-303, it is not copyrighted, but is the property of

Marshall Space Flight Center Black History Month Program

NASA Image and Video Library

2018-02-21

The Black History Month program was presented at Marshall Space Flight Center with guest speaker Lt. General Stayce Harris. General Harris is the Inspector General of the Air Force and she is the first African American female Lieutenant General in the American military. The topic of her presentation was "African Americans in Times of War". The presentation was followed by an ethnic food sampling. General Harris is pictured here with local area Air Force JROTC cadets who attended the program.

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

Thermal annealing and pressure effects on BaFe_2-xCo_xAs₂ single crystals.

PubMed

Shin, Dongwon; Jung, Soon-Gil; Prathiba, G; Seo, Soonbeom; Choi, Ki-Young; Kim, Kee Hoon; Park, Tuson

2017-11-26

We investigate the pressure and thermal annealing effects on BaFe_2-<i>x</i>Co_<i>x</i>As₂ (Co-Ba122) single crystals with <i>x</i> = 0.1 and 0.17 via electrical transport measurements. The thermal annealing treatment not only enhances the superconducting transition temperature (<i>T</i>_c) from 9.6 to 12.7 K for <i>x</i> = 0.1 and from 18.1 to 21.0 K for <i>x</i> = 0.17, but also increases the antiferromagnetic transition temperature (<i>T</i>_N). Simultaneous enhancement of <i>T</i>_c and <i>T</i>_N by the thermal annealing treatment indicates that thermal annealing could substantially improve the quality of the Co-doped Ba122 samples. Interestingly, <i>T</i>_c of the Co-Ba122 compounds shows a scaling behavior with a linear dependence on the resistivity value at 290 K, irrespective of tuning parameters, such as chemical doping, pressure, and thermal annealing. These results not only provide an effective way to access the intrinsic properties of the BaFe₂As₂ system, but also may shed a light on designing new materials with higher superconducting transition temperature. © 2017 IOP Publishing Ltd.

Investigating energy deposition within cell populations using Monte Carlo simulations.

PubMed

Oliver, Patricia A K; Thomson, Rowan M

2018-06-27

In this work, we develop multicellular models of healthy and cancerous human soft tissues, which are used to investigate energy deposition in subcellular targets, quantify the microdosimetric spread in a population of cells, and determine how these results depend on model details. Monte Carlo (MC) tissue models combining varying levels of detail on different length scales are developed: microscopically-detailed regions of interest (>1500 explicitly-modelled cells) are embedded in bulk tissue phantoms irradiated by photons (20 keV to 1.25 MeV). Specific energy (<i>z</i>; energy imparted per unit mass) is scored in nuclei and cytoplasm compartments using the EGSnrc user-code egs_chamber; specific energy mean, <<i>z</i>>, standard deviation, <i>σ</i>_<i>z</i>, and distribution, <i>f</i>(<i>z</i>,<i>D</i>), are calculated for a variety of macroscopic doses, <i>D</i>. MC-calculated <i>f</i>(<i>z</i>,<i>D</i>) are compared with normal distributions having the same mean and standard deviation. For mGy doses, there is considerable variation in energy deposition (microdosimetric spread) throughout a cell population: <i>e</i>.<i>g</i>., for 30 keV photons irradiating melanoma with 7.5 μm cell radius and 3 μm nuclear radius, <i>σ</i>_<i>z</i>/<<i>z</i>> for nuclear targets is 170%, and the fraction of nuclei receiving no energy deposition, <i>f</i>_<i>z</i>=0, is 0.31 for a dose of 10 mGy. If cobalt-60 photons are considered instead, then <i>σ</i>_<i>z</i>/<<i>z</i>> decreases to 84%, and <i>f</i>_<i>z</i>=0 decreases to 0.036. These results correspond to randomly arranged cells with cell/nucleus sizes randomly sampled from a normal distribution with a standard deviation of 1 μm. If cells are arranged in a hexagonal lattice and cell/nucleus sizes are uniform throughout the population, then <i>σ</i>_<i>z</i>/<<i>z</i>> decreases to 106% and 68% for 30 keV and cobalt-60,respectively; <i>f</i>_<i>z</i>=0 decreases to 0.25 and 0.00094 for 30 keV and cobalt-60, respectively. Thus, specific energy distributions are sensitive to cell/nucleus sizes and their distributions: variations in specific energy deposited over a cell population are underestimated if targets are assumed to be uniform in size compared with more realistic variation in target size. Bulk tissue dose differs from <<i>z</i>> for nuclei (cytoplasms) by up to 21% (12%) across all cell/nucleus sizes, bulk tissues, and incident photon energies, considering a 50 mGy dose level. Overall, results demonstrate the importance of microdosimetric considerations at low doses, and indicate the sensitivity of energy deposition within subcellular targets to incident photon energy, dose level, elemental compositions, and microscopic tissue model. © 2018 Institute of Physics and Engineering in Medicine.

Mars Thermospheric Temperature Sensitivity to Solar EUV Forcing from the MAVEN EUV Monitor

NASA Astrophysics Data System (ADS)

Thiemann, Ed; Eparvier, Francis; Andersson, Laila; Pilinski, Marcin; Chamberlin, Phillip; Fowler, Christopher; MAVEN Extreme Ultraviolet Monitor Team, MAVEN Langmuir Probe and Waves Team

2017-10-01

Solar extreme ultraviolet (EUV) radiation is the primary heat source for the Mars thermosphere, and the primary source of long-term temperature variability. The Mars obliquity, dust cycle, tides and waves also drive thermospheric temperature variability; and it is important to quantify the role of each in order to understand processes in the upper atmosphere today and, ultimately, the evolution of Mars climate over time. Although EUV radiation is the dominant heating mechanism, accurately measuring the thermospheric temperature sensitivity to EUV forcing has remained elusive, in part, because Mars thermospheric temperature varies dramatically with latitude and local time (LT), ranging from 150K on the nightside to 300K on the dayside. It follows that studies of thermospheric variability must control for location.Instruments onboard the Mars Atmosphere and Volatile EvolutioN (MAVEN) orbiter have begun to characterize thermospheric temperature sensitivity to EUV forcing. Bougher et al. [2017] used measurements from the Imaging Ultraviolet Spectrograph (IUVS) and the Neutral Gas and Ion Mass Spectrometer (NGIMS) to characterize solar activity trends in the thermosphere with some success. However, aside from restricting measurements to solar zenith angles (SZAs) below 75 degrees, they were unable to control for latitude and LT because repeat-track observations from either instrument were limited or unavailable.The MAVEN EUV Monitor (EUVM) has recently demonstrated the capability to measure thermospheric density from 100 to 200 km with solar occultations of its 17-22 nm channel. These new density measurements are ideal for tracking the long-term thermospheric temperature variability because they are inherently constrained to either 06:00 or 18:00 LT, and the orbit has precessed to include a range of ecliptic latitudes, a number of which have been revisited multiple times over 2.5 years. In this study we present, for the first-time, measurements of thermospheric temperature sensitivity to EUV forcing derived from the EUVM measurements. These results include sensitives measured at the poles and near the equator for both terminators; therefore, we will also discuss the role of latitude on EUV temperature sensitivity.

Air and Space Power Journal. Volume 16, Number 4, Winter 2002

DTIC Science & Technology

2002-01-01

www.wpafb.af.mil/ museum/research/bombers/ b1 -10.htm. The Oath of Office A Historical Guide to Moral Leadership LT COL KENNETH KESKEL, USAF Editorial...typical of the Royal Air Force (RAF) between the wars, excelling at rugby , boxing, and cricket (in which he was scheduled to compete for England

Annual Progress Report and Report of Significant Accomplishments.

DTIC Science & Technology

1982-04-01

1980 to February 28, 1981 (March 1981). 3247 Se-Jung Oh and S. Doniach, " Fluorescent NSF DMR79-13102 Electron Emission--A Prediction for Resonant...Griffiss AFB, NY 13411 Lt. Clarence Gardner Dr. Tom Walsh Air Force Office of Scientific Research AFOSR/NE AFOSR/NE Boiling AFB, DC 20332 Bolling AFB, DC

KSC-08pd0915

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane fly over the Launch Complex 39 area in their U.S. Navy F-18 Hornet as they return to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0919

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane board their U.S. Navy F-18 Hornet as they prepare to return to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0922

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane prepare for takeoff of their U.S. Navy F-18 Hornet from the Shuttle Landing Facility for the return flight to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0912

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane arrive at NASA's Kennedy Space Center. Behind them is one of the U.S. Navy F-18 Hornets flown by the Blue Angels. The pilots flew into Kennedy to begin preparations for their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0916

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane arrive at NASA's Kennedy Space Center. Behind them is one of the U.S. Navy F-18 Hornets flown by the Blue Angels. The pilots flew into Kennedy to begin preparations for their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0913

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane take a last look at the center from their U.S. Navy F-18 Hornet as they return to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0917

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane pose for the media in front of one of the U.S. Navy F-18 Hornets flown by the Blue Angels. The pilots flew into NASA's Kennedy Space Center to begin preparations for their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0911

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- A U.S. Navy F-18 Hornet taxis on the Shuttle Landing Facility runway at NASA's Kennedy Space Center. Aboard are Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane. They flew into Kennedy to begin preparations for their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0921

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane prepare for takeoff of their U.S. Navy F-18 Hornet from the Shuttle Landing Facility for the return flight to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0914

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane take a last look at the center from their U.S. Navy F-18 Hornet as they return to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0920

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane board their U.S. Navy F-18 Hornet as they prepare to return to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0923

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane take off from the Shuttle Landing Facility aboard their U.S. Navy F-18 Hornet for the return flight to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0924

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- After meeting with NASA officials about their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9, Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane take off from the Shuttle Landing Facility aboard their U.S. Navy F-18 Hornet for the return flight to their home base in Pensacola, Fla. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0918

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane arrive at NASA's Kennedy Space Center. Behind them is one of the U.S. Navy F-18 Hornets flown by the Blue Angels. The pilots flew into Kennedy to begin preparations for their involvement in the second annual Space & Air Show at Kennedy Nov. 8-9. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

KSC-08pd0910

NASA Image and Video Library

2008-04-07

CAPE CANAVERAL, Fla. -- A U.S. Navy F-18 Hornet lands at the Shuttle Landing Facility at NASA's Kennedy Space Center. Aboard are Blue Angel pilots Lt. Frank Weisser and Lt. Dan McShane. They flew into Kennedy to begin preparations for their involvement in the second annual Space & Air Show at Kennedy Space Center Nov. 8-9. The air show will be only the second time the Blue Angels have performed at Kennedy. Their precision flight team will perform high-speed passes, fast rolls, mirror formations, tight turns and their signature Delta formation showcasing the capabilities of the powerful aircraft. The 2008 Space & Air Show will include aircraft displays and space-related exhibits on the ground and plenty of action in the skies over Kennedy. Returning to the show is the 920th Rescue Wing, an Air Force Reserve Command combat search and rescue unit based at Patrick Air Force Base in Central Florida. Also, more than 20 astronauts and special guests will be on hand to personally meet guests, pose for photos and sign memorabilia. Photo credit: NASA/Kim Shiflett

A new approach to implant alignment and ligament balancing in total knee arthroplasty focussing on joint loads.

PubMed

Zimmermann, Frauke; Schwenninger, Christoph; Nolten, Ulrich; Firmbach, Franz Peter; Elfring, Robert; Radermacher, Klaus

2012-05-06

Preservation and recovery of the mechanical leg axis as well as good rotational alignment of the prosthesis components and well-balanced ligaments are essential for the longevity of total knee arthroplasty (TKA). In the framework of the OrthoMIT project, the genALIGN system, a new navigated implantation approach based on intra-operative force-torque measurements, has been developed. With this system, optical or magnetic position tracking as well as any fixation of invasive rigid bodies are no longer necessary. For the alignment of the femoral component along the mechanical axis, a sensor-integrated instrument measures the torques resulting from the deviation between the instrument's axis and the mechanical axis under manually applied axial compression load. When both axes are coaxial, the resulting torques equal zero, and the tool axis can be fixed with respect to the bone. For ligament balancing and rotational alignment of the femoral component, the genALIGN system comprises a sensor-integrated tibial trial inlay measuring the amplitude and application points of the forces transferred between femur and tibia. Hereby, the impact of ligament tensions on knee joint loads can be determined over the whole range of motion. First studies with the genALIGN system, including a comparison with an imageless navigation system, show the feasibility of the concept.

KSC-03PD-2820

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. Employees fill the Training Auditorium for the kickoff presentation for Spaceport Super Safety and Health Day. Along with Center Director Jim Kennedy, guest speakers were Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, Maj. Gen. Kevin Chilton, and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

KSC-03PD-2821

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, speaks to the employees and guests gathered in the KSC Training Auditorium for Spaceport Super Safety and Health Day. The kickoff presentation also included speakers Maj. Gen. Kevin Chilton and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

KSC-03PD-2822

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. Maj. Gen. Kevin Chilton speaks to the employees and guests gathered in the KSC Training Auditorium for Spaceport Super Safety and Health Day. The kickoff presentation also included speakers Brig. Gen. J. Gregory Pavlovich, 45th Space Wing, and Capt. Charles Plumb (USNR retired), who spoke about his experiences in the Navy and as a prisoner of war in Vietnam. Spaceport Super Safety and Health Day is an annual event at KSC and Cape Canaveral Air Force Station dedicated to reinforcing safe and healthful behaviors in the workforce. Safety Awards were also given to individuals and groups.

KSC-04pd1257

NASA Image and Video Library

2004-06-09

KENNEDY SPACE CENTER, FLA. - At Cape Canaveral Air Force Station, Firefighter Chris Maupin (left) and Lt. Keith Abell demonstrate how the special aircraft firefighting vehicle (known as ARF) was used at the site of a recent fire in Brevard County, Fla. The firefighters sit inside the vehicle with a "driver" in the middle. They are able to direct the hoses to attack fires from above and below. The firefighters teamed up with task forces from Satellite Beach, Malabar, Melbourne, Palm Bay, Patrick Air Force Base and Brevard County to help fight wildfires in the Palm Bay and Malabar areas that threatened homes and property during the Memorial Day holiday weekend.

Farewell to the Chairman - Marine Gen. Peter Pace

Science.gov Websites

Colombian or foreign officer. Defense Dept. photo by U.S. Air Force Staff Sgt. D. Myles Cullen Colombia's Boyaca, the highest military award that can be conferred on a Colombian or foreign officer. Story

Magnetic and electronic properties of the Cu-substituted Weyl semimetal candidate ZrCo₂Sn.

PubMed

Kushwaha, S K; Wang, Zhijun; Kong, Tai; Cava, Robert

2018-01-04

We report that the partial substitution of Cu for Co has a significant impact on the magnetic properties of the Heusler-phase Weyl fermion candidate ZrCo₂Sn. Polycrystalline samples of ZrCo_2-<i>x</i>Cu_<i>x</i>Sn (<i>x</i> = 0.0 to 1.0) exhibited a linearly decreasing ferromagnetic transition temperature and similarly decreasing saturated magnetic moment on increasing Cu substitution x. Materials with Cu contents near <i>x</i> = 1 and several other quaternary materials synthesized at the same <i>x</i> (ZrCo<i>T</i>'Sn (<i>T</i>' = Rh, Pd, Ni)) display what appears to be non-ferromagnetic magnetization behavior with spin glass characteristics. Electronic structure calculations suggest that the half-metallic nature of unsubstituted ZrCo₂Sn is disrupted significantly by the Cu substitutions, leading to the breakdown of the magnetization vs. electron count guidelines usually followed by Heusler phases, and a more typical metallic non-spin-polarized electronic structure at high <i>x</i>. © 2018 IOP Publishing Ltd.

Magnetization, resistivity, specific heat and ab initio calculations of Gd₅Sb₃.

PubMed

Samatham, S Shanmukharao; Patel, Akhilesh Kumar; Lukoyanov, Alexey V; Suresh, K G

2018-06-07

We report on the combined results of structural, magnetic, transport and calorimetric properties of Mn₅Si₃-type hexagonal Gd₅Sb₃, together with <i>ab-initio</i> calculations. It exhibits a ferromagnetic (FM)-like transition at 265 K, antiferromagnetic (AFM) Néel transition at 95.5 K followed by a spin-orientation transition at 62 K. The system is found to be in AFM state down to 2 K in a field of 70 kOe. The FM-AFM phase coexistence is not noticeable despite large positive Curie-Weiss temperature (θ_CW = 223.5 ± 0.2 K). Instead, low-temperature AFM and high-temperature FM-like phases are separated in large temperatures. Temperature-magnetic field (<i>H</i>-<i>T</i>) phase diagram reveals field-driven complex magnetic phases. Within the AFM phase, the system is observed to undergo field-driven spin-orientation transitions. Field-induced tricritical and quantum critical points appear to be absent due to strong AFM nature and by the intervention of FM-like state between paramagnetic and AFM states, respectively. The metallic behavior of the compound is inferred from resistivity along with large Sommerfeld parameter. However, no sign of strong electron-correlations is reasoned from the Kadowaki-Wood's ratio <i>A</i>/γ² ∼ 1.9×10^-6 μΩ.cm.(mol.K)²(mJ)^-2, despite heavy γ. Essentially, <i>ab initio</i> calculations accounting for electronic correlations confirm AFM nature of low-temperature magnetic state in Gd₅Sb₃ and attainable FM ordering in agreement with experimental data. © 2018 IOP Publishing Ltd.

Final Environmental Assessment for Proposed Airspace Changes for Paradise East and Paradise West Military Operations Areas (MOAs) at Mountain Home Air Force Base (MHAFB) Idaho

DTIC Science & Technology

2010-03-29

IR FO R C E\\ 32 99 91 AI R SP A C E EA \\G IS \\M X D \\F IG U R E- A LT ER N AT IV E A. M X D M KO U BE K...basis. BO I \\\\O W L\\ PR O J\\ M O U N TA IN H O M EA IR FO R C E\\ 32 99 91 AI R SP A C E EA \\G IS \\M X D \\F IG U R E- A LT ER N AT IV E B. M X D M KO...MTR. MTR segments are identified and charted as either IR routes (IFR) or VR routes

Air Force Fixed-Wing Rescue: A Multifaceted Approach for Full-Spectrum Personnel Recovery

DTIC Science & Technology

2011-01-01

to the author, e-mail, 29 June 2011. The cost per flying hour is in fiscal year 2011 constant dollars. 11. Ibid.; and Lt Col Brian Pitcher ...personnel could provide maintenance support for one or several small aircraft. This assumes fully trained and licensed air- frame and power- plant mechanics

Air and Space Expeditionary Force Crisis Action Leadership for Commanders

DTIC Science & Technology

2004-04-01

2002), 337. 2 Mark, Friedman, M.D., Everyday Crisis Management (Naperville, IL: First Decision Press, 2002), 5. 3 Stephen R. Covey, The 7 Habits of Highly Effective People (New...Berkley Publishing Group, 2002), 9. 12 Lt Col Bryan Gallagher, USAF, interviewed by author, February 2004. 13 Stephen R. Covey, The 7 Habits of Highly Effective People (New

NATO’s Air War in Libya: A Template for Future American Operations

DTIC Science & Technology

2012-06-08

Misner and Lt Col Krishna, thank you for the lessons in leadership and mentoring that allowed me the opportunity to attend this school. I would also...him at odds with the United States civilian leadership who did not want to commit ground forces. Lastly, the book exposes some of the tensions...

Business Reengineering - Government Viability

DTIC Science & Technology

2000-04-01

BUSINESS REENGINEERING - GOVERNMENT VIABILITY BY LIEUTENANT COLONEL GRAY K. COYNER United States Air Force Reserve DISTRIBUTION STATEMENT A: Approved...PROJECT Business Reengineering - Government Viability by Lt Col Gray K. Coyner USAFR Col Harry E. LeBoeuf Jr. Project Advisor The views expressed in...release. Distribution is unlimited. ii ABSTRACT AUTHOR: Gray K. Coyner TITLE: Business Reengineering - Government Viability FORMAT: Strategy Research

Transformation in the French Air Force in an Era of Change

DTIC Science & Technology

2008-01-01

Abria.indd 6 10/30/08 1:15:37 PM Transformation in the French Air Force in an Era of Change Général d’armée aérienne Stéphane Abrial, chef...l’armée l’air,” sponsored by the Centre d’études stratégiques aérospatiales, 3 June 2008. The French Air Force, like all defense organizations...related to our equipment, because the French aircraft Gen Stéphane Abrial is the chief of staff of the French Air Force. He completed the French Air

United States Air Force Statistical Digest, Fiscal Year 1959. Fourteenth Edition

DTIC Science & Technology

1959-09-30

Support Forces for fiscal year 1959 consist of Air Refueling; Strategic Support; Airborne Early Warning and Control; Radar Evaluation ;.He11cop~er...missions. (EI) Test: Aircraft assigned to evaluate the aircraft and/or its components installed as standard equipment. (EH) Test Support: Aircraft... consumables under two AF-GEN sub-projects: PROJECT SEAWEED and PROJECT NIGHT LIFE & FLYAWAY KITS. Also included in this section is data on ammunition

Proceedings of Workshop on Atmospheric Density and Aerodynamic Drag Models for Air Force Operations Held at Air Force Geophysics Laboratory on 20-22 October 1987. Volume 2

DTIC Science & Technology

1990-02-13

spacecraft had near-polar orbits except for AE-C (680) and AE-E (190). This exten- sive lower thermosphere data set has been obtained over a wide...two satellite data sets is believed due mainly to uncertainties in the ballistic coefficients used to convert orbital drag measurements to atmospheric...eccentricity sun-synchronous orbit (1400/0200 LT) would provide data in local time-latitude regions not covered by the present data set . Coordination with

Climatic Variations in Tropical West African Rainfall and the Implications for Military Planners

DTIC Science & Technology

2008-06-01

perturbation pressure isobars. There is a ridge in (a) and a trough in (b) at the equator and to the east of the forcing region. Note that the pressure...Climatology course project team), CDR Eric Buch (C6F Oceanographer), Mr. Samson Brand (NRL Monterey), VADM Paul Gaffney (ret.), Prof. Russell Elsberry, LT...pressure isobars. There is a ridge in (a) and a trough in (b) at the equator and to the east of the forcing region. Note that the pressure to the west

Improvement of liver stiffness measurement, acoustic radiation force impulse measurements, and noninvasive fibrosis markers after direct-acting antivirals for hepatitis C virus G4 recurrence post living donor liver transplantation: Egyptian cohort.

PubMed

Alem, Shereen Abdel; Said, Mohamed; Anwar, Ismail; Abdellatif, Zeinab; Elbaz, Tamer; Eletreby, Rasha; AbouElKhair, Mahmoud; El-Serafy, Magdy; Mogawer, Sherif; El-Amir, Mona; El-Shazly, Mostafa; Hosny, Adel; Yosry, Ayman

2018-05-02

Progression of recurrent hepatitis C is accelerated in liver transplant (LT) recipients. Direct-acting antivirals (DAAs) have recently emerged as a promising therapeutic regimen for the treatment of hepatitis C virus infection. Rates of sustained virological response (SVR) have drastically improved since the introduction of DAAs. The aim is to elucidate the changes in liver stiffness measurement (LSM) by transient elastography (TE) as well as acoustic radiation force impulse (ARFI) elastography and fibrosis scores after DAA treatment in LT recipients with hepatitis C virus recurrence. A single-center, prospective study including 58 LT recipients with hepatitis C recurrence who received different sofosbuvir-based treatment regimens. Transient elastography and ARFI elastography values were recorded as well as fibrosis 4 score (FIB-4) and aspartate aminotransferase-to-platelet ratio index were calculated at baseline and SVR at week 24 (SVR24). The outcome was improvement in LSM and at least a 20% decrease in LSM at SVR24 compared with baseline. The sustained virological response was 98.1%. There was improvement of platelet counts, alanine aminotransferase, and aspartate aminotransferase, which in turn caused improvement in fibrosis scores at SVR24. LSM by TE and ARFI elastography decreased from the baseline median value of 6.3 kPa (interquartile range [IQR]; 4.6 to 8.8 kPa) and 1.28 m/s (IQR; 1.07 to 1.53 m/s) to an SVR24 median value of 6.2 kPa (IQR; 4.85 to 8.9 kPa) and 1.12 (IQR; 0.97 to 1.30 m/s), respectively. Logistic regression analysis showed that baseline viral load was the only significant predictor of improvement in LS after DAA therapy at SVR24. Sofosbuvir-based treatment resulted in an early improvement in parameters of liver fibrosis in post-LT patients with hepatitis C recurrence. © 2018 Wiley Periodicals, Inc.

Cholecalciferol supplementation of heifer diets increases beef vitamin D concentration and improves beef tenderness.

PubMed

Duffy, Sarah K; O'Doherty, John V; Rajauria, Gaurav; Clarke, Louise C; Cashman, Kevin D; Hayes, Aoife; O'Grady, Michael N; Kerry, Joseph P; Kelly, Alan K

2017-12-01

This study investigated the effects of cholecalciferol (vitamin D₃) supplementation on beef vitamin D activity, beef tenderness and sensory attributes. Thirty heifers were randomly allocated to one of three finishing dietary treatments [(T1) basal diet+0IU vitamin D₃; (T2) basal diet+2000IU vitamin D₃; and (T3) basal diet+4000IU vitamin D₃] for a 30day period pre-slaughter. Vitamin D₃ supplementation linearly increased serum 25-hydroxyvitamin D₃ (25-OH-D 3 ) concentrations (R 2 =0.48), Longissimus thoracis (LT) total vitamin D activity (R 2 =0.78) as well as individually vitamin D₃ (R 2 =0.84) and 25-OH-D₃ (R 2 =0.75). The highest vitamin D₃ inclusion diet (T3) had a 42% increase (P<0.001) in LT vitamin D activity compared to the intermediate diet (T2) and a 145% increase over the lowest level diet (T1). Vitamin D₃ supplementation decreased LT shear (P<0.05) force values after 14days chilling. Sensory parameters were not affected (P>0.05). In conclusion, through short-term vitamin D₃ supplementation of cattle diets, beef vitamin D activity can successfully be enhanced. Copyright © 2017 Elsevier Ltd. All rights reserved.

Defense and Arms Control Studies Program

DTIC Science & Technology

1991-01-01

States Military Academy, Poli. Sci. Massachusetts Institute of Technol- ogy, Electr. Eng. Craig Wheeler Cynthia Womack University of California-San...of the Assistant Secretary of Defense (Program Analysis and Evaluation), "Total Force Policy" November 6 - M. Gen. Gene A. Deegan , USMC Vice Director

International Quick Response Forces

DTIC Science & Technology

1994-06-06

RESPONSIBLE INDIVIDUAL 22b. TELEPHONE (include Area Code) 22c O;FICE SYMBOL PROFE SOR JOHN B. HATTENDORF (401)8641 i13i 35 DD Form 1473. JUN 86...sooner - therein lies the utility of rapid response forces. 42 John F. Burns, "UN Peacekeeping Moves into Yugoslavia," The New York Times, March 15...more challenging and more resource intensive it becomes.44 - GEN John Shalikashvili Chairman, Joint Chiefs of Staff former Supreme Allied Commander

A Design Method and an Application for Contrarotating Propellers

DTIC Science & Technology

1990-01-01

force gen- stricted to uniform flow , it fhowed that the analysis of CR pro- erated by the contrarotating propeller to be balanced by the drag... uniform flow at where the operating point of the propeller for a typical high-speed sur- ,/2 face ship. Force measurements for the CR propelier in... experimental thrust coefficient, torque Bronze. Since this propeller set is designed for uniform flow , coefficient, and efficiency for the CR propellers

Validity and Reliability of the PUSH Wearable Device to Measure Movement Velocity During the Back Squat Exercise.

PubMed

Balsalobre-Fernández, Carlos; Kuzdub, Matt; Poveda-Ortiz, Pedro; Campo-Vecino, Juan Del

2016-07-01

Balsalobre-Fernández, C, Kuzdub, M, Poveda-Ortiz, P, and Campo-Vecino, Jd. Validity and reliability of the PUSH wearable device to measure movement velocity during the back squat exercise. J Strength Cond Res 30(7): 1968-1974, 2016-The purpose of this study was to analyze the validity and reliability of a wearable device to measure movement velocity during the back squat exercise. To do this, 10 recreationally active healthy men (age = 23.4 ± 5.2 years; back squat 1 repetition maximum [1RM] = 83 ± 8.2 kg) performed 3 repetitions of the back squat exercise with 5 different loads ranging from 25 to 85% 1RM on a Smith Machine. Movement velocity for each of the total 150 repetitions was simultaneously recorded using the T-Force linear transducer (LT) and the PUSH wearable band. Results showed a high correlation between the LT and the wearable device mean (r = 0.85; standard error of estimate [SEE] = 0.08 m·s) and peak velocity (r = 0.91, SEE = 0.1 m·s). Moreover, there was a very high agreement between these 2 devices for the measurement of mean (intraclass correlation coefficient [ICC] = 0.907) and peak velocity (ICC = 0.944), although a systematic bias between devices was observed (PUSH peak velocity being -0.07 ± 0.1 m·s lower, p ≤ 0.05). When measuring the 3 repetitions with each load, both devices displayed almost equal reliability (Test-retest reliability: LT [r = 0.98], PUSH [r = 0.956]; ICC: LT [ICC = 0.989], PUSH [ICC = 0.981]; coefficient of variation [CV]: LT [CV = 4.2%], PUSH [CV = 5.0%]). Finally, individual load-velocity relationships measured with both the LT (R = 0.96) and the PUSH wearable device (R = 0.94) showed similar, very high coefficients of determination. In conclusion, these results support the use of an affordable wearable device to track velocity during back squat training. Wearable devices, such as the one in this study, could have valuable practical applications for strength and conditioning coaches.

Confidence Intervals for System Reliability and Availability of Maintained Systems Using Monte Carlo Techniques

DTIC Science & Technology

1981-12-01

DTIC _JUN ,I 51982 UNITED STATES AIR FORCE AIR UNIVERSITY E AIR FORCE INSTITUTE OF TECHNOLOGY Wright-Patterson Air-force Base,Ohio S 2 B 14 Best...t’re Air F:or- e -ns"it’.,, e of Technclogy Air Uv-ýerz.tyj in Partial 𔄁ulfilIThent Reýquirements fol- ,-hth D,ýýr.e c4" MastLer of’ OperaZ-ins...iesearc- VeTA 3 MohamedO ’’’’Jo SpD’ Fas.abal-la Lt. C ol. Egyplt.’.an Army Gradua~’p ( ler ons Research December 1981 Approcved fL~r pu>ý’ rclea.se

KSC-08pd3590

NASA Image and Video Library

2008-11-07

CAPE CANAVERAL, Fla. – Center Director Bob Cabana presents an award to retired U.S. Air Force Lt. Col. Lee A. Archer Jr., one of the Tuskegee Airmen, during a special presentation to the work force at NASA's Kennedy Space Center in Florida. Archer shared his experiences as combat fighter pilot, civil rights leader and business executive. Archer is the only Tuskegee Airmen fighter pilot to receive the honor “Ace” for shooting down five enemy aircraft during WWII. He retired as Air Force Command Pilot after 30 years of military service, 1941-1971. Archer is at Kennedy to serve as Military Marshall of the 2008 KSC Space & Air Show, Nov. 8-9. Photo credit: NASA/Kim Shiflett

KSC-08pd3591

NASA Image and Video Library

2008-11-07

CAPE CANAVERAL, Fla. – Retired U.S. Air Force Lt. Col. Lee A. Archer Jr. (seated at center), one of the Tuskegee Airmen, autographs photos for guests after a special presentation to the work force at NASA's Kennedy Space Center in Florida. Archer shared his experiences as combat fighter pilot, civil rights leader and business executive. Archer is the only Tuskegee Airmen fighter pilot to receive the honor “Ace” for shooting down five enemy aircraft during WWII. He retired as Air Force Command Pilot after 30 years of military service, 1941-1971. Archer is at Kennedy to serve as Military Marshall of the 2008 KSC Space & Air Show, Nov. 8-9. Photo credit: NASA/Kim Shiflett

Shock-Induced Reaction in Carbon Disulfide.

DTIC Science & Technology

1980-04-01

Tech Ctr Dept. of the Navy Attn: Dr. F. Roberto Attn: Dr. David C. Sayles Room 901 Dr. C. Merrill, Lt.S.Clift P.O. Box 1500 Washington, DC 20376 Mr. R...Sciences Attn: Dr. H. P. Marshall, Energy Center Bolling Air Force Base Dept. 52-35 Mail Code B-0l0 i Washington, DC 20332 3251 Hanover St. La Jolla, CA

Gemini 4 prime crew with Official medical nurse for Astronaut crew members

NASA Technical Reports Server (NTRS)

1965-01-01

Gemini 4 prime crew, Astronauts Edward H. White II, (left), and James A. McDivitt (right) are shown with Lt. Dolores (Dee) O'Hare, US Air Force, Center Medical Office, Flight Medicine Branch, Manned Spaceflight Center (MSC). Lieutenant O'Hare has served during several space flights as Official medical nurse for the astronaut crew members on the missions.

ARC-1958-A-23928

NASA Image and Video Library

1958-05-21

NACA Photographer Thrust reverser on F-94C-1 (AF50-956 NACA 156) Starfire (l to R) Air Force Major E. Sommerich; Ames Engineer Seth Anderson, Lt. Col. Tavasti; and Ames Chief test pilot George Cooper discussing phases of flight evaluation tests. Note: Used in publication in Flight Research at Ames; 57 Years of Development and Validation of Aeronautical Technology NASA SP-1998-3300 fig 91

SHOWN WITH NURSE - ASTRONAUT EDWARD H. WHITE II - MISC. - CAPE

NASA Image and Video Library

1965-06-01

S65-29657 (June 1965) --- Gemini-4 prime crew, astronauts Edward H. White II (left), and James A. McDivitt are shown with Lt. Dolores (Dee) O'Hare, US Air Force, Center Medical Office, Flight Medicine Branch, Manned Spacecraft Center (MSC). Lieutenant O'Hare has served during several spaceflights as official medical nurse for the astronaut crew members on the missions.

U.S. Department of Defense Official Website - World War II Memorial

Science.gov Websites

- The newly opened World War II Memorial on the National Mall in Washington, D.C., was dedicated May 29 . It honors the 16 million who served in the armed forces of the United States during World War II, the ;greatest generation." Defense Department photo illustration by Navy Lt. Cmdr. Jane Campbell World War

Liquid L-thyroxine versus tablet L-thyroxine in patients on L- thyroxine replacement or suppressive therapy: a meta-analysis.

PubMed

Laurent, Irakoze; Tang, Siying; Astère, Manirakiza; Wang, Kan Ran; Deng, Shuhua; Xiao, Ling; Li, Qi Fu

2018-03-23

To compare the effectiveness of liquid L-T4 (L-thyroxine) and tablet L-T4 in patients on L-T4 replacement or suppressive therapy. The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All prospective or randomized controlled studies (RCTs) comparing liquid L-T4 and tablet L-T4 in patients on L-T4 replacement or suppressive therapy were included in the analysis. Overall, the initial search of the four databases identified 1278 published studies; of these, eight studies were ultimately included in the meta-analysis. TSH (thyroid stimulating hormone) levels were significantly suppressed in patients on liquid L-T4 compared with those on tablet L-T4, in patients on L-T4 suppressive therapy with L-T4 malabsorption (Mean Difference (MD) = -2.26, 95% Confidence Interval (CI): -3.59, -0.93; P = 0.0009)). However, liquid L-T4 and tablet L-T4 did not show a statistically significant difference in patients on L-T4 suppressive therapy without malabsorption (MD = 0.08, 95% CI: -0.31, 0.47; P = 0.69). TSH levels were significantly normalized in patients on liquid L-T4 compared with those on tablet L-T4, in Patients on L-T4 replacement therapy with L-T4 malabsorption (MD = -3.20, 95% CI: -5.08, -1.32; P = 0.0009). However, liquid L-T4 and tablet L-T4 did not show a statistically significant difference in patients on L-T4 replacement therapy without malabsorption (MD = 0.91, 95% CI: -0.03, 1.86; P = 0.06). Liquid L-T4 is more efficient than tablet L-T4 in patients on L-T4 replacement or suppressive therapy with malabsorption. No significant differences were observed in patients without malabsorption. Further studies should be conducted to verify these findings.

Stable High-Performance Perovskite Solar Cells Based on Inorganic Electron Transporting Bi-layers.

PubMed

Gu, Hao; Zhao, Chen; Zhang, Yiqiang; Shao, Guosheng

2018-06-27

As one of the significant electron transporting materials (ETM) in efficient planar heterojunction perovskite solar cells (PSCs), SnO₂ can collect/transfer photo-generated carriers produced in perovskite active absorbers and suppress the carrier recombination at interfaces. In this study, we demonstrate that mild solution-processed SnO₂ compact layer can be an eminent ETM for planar heterojunction PSCs. Here, the device based on chemical-bath-deposited SnO₂ electron transporting layer (ETL) exhibits a power conversion efficiency (PCE) of 16.10% and with obvious hysteresis effect (hysteresis index=19.5%), owing to the accumulation and recombination of charge carriers at SnO₂/perovskite interface. In order to improve the carrier dissociation and transport process, an ultrathin TiO₂ film was deposited on the top of SnO₂ ETL passivating nonradiative recombination center. The corresponding device based on TiO₂@SnO₂ electron transporting bi-layer (ETBL) exhibited a high PCE (17.45%) and a negligible hysteresis effect (hysteresis index=1.5%). These findings indicate that this facile solution-processed TiO₂@SnO₂ ETBL paves a scalable and inexpensive way for fabricating hysteresis-less and high-performance PSCs. © 2018 IOP Publishing Ltd.

Joint Special Operations University SOF-Power Workshop: A Way Forward for Special Operations Theory and Strategic Art

DTIC Science & Technology

2011-08-01

participants‘ particular points of view and may be helpful in researching, developing, testing, and explaining theory. The Secret War in Laos was...Jan 1985. Tse -Tung, Mao. On Guerrilla Warfare. Praeger, New York: 1961. The Use and Utility of Force; Force Fungibles Art, Robert J. and...Penguin Books, New York: 1968. Griffith, Samuel B., (BrigGen (Ret) USMC). On Guerrilla Warfare – Mao Tse -Tung. Praeger, New York: 1961

Minority Report: Potential Challenges in Employing Global Strike Against Violent Non-State Actors in 2035

DTIC Science & Technology

2012-02-13

for Academic Year 2012, 19 May 2011. 2 Thomas K. Anderson, et al ., Air Force Doctrine Document (AFDD) 3-60: Targeting (Montgomery, AL : Lemay...Gen Robert W. Mixon, et al ., Multi-Service Tactics, Techniques, and Procedures for Targeting Time-Sensitive Targets (Ft Monroe, VA: U.S. Army...intelligence is all-knowing. 26 References Anderson, Thomas K., et al ., Air Force Doctrine Document (AFDD) 3-60: Targeting (Montgomery, AL : Lemay

General Thomas Dresser White: Renaissance Man in a Dark Age

DTIC Science & Technology

2015-06-01

Interview with Maj Gen Haywood S. Hansell,” interview by Edgar F. Puryear, Jr., February 25, 1979 , Air Force Historical Research Agency. 66 Puryear...man in space, the Air Force collaborated with NASA to develop the Dyna- Soar , a manned spacecraft launched via a Titan rocket and returned as a...glider. For White, “The Dyna- Soar …is the first vehicle which will combine the advantages of manned aircraft and missiles into a

From AWE-GEN to AWE-GEN-2d: a high spatial and temporal resolution weather generator

NASA Astrophysics Data System (ADS)

Peleg, Nadav; Fatichi, Simone; Paschalis, Athanasios; Molnar, Peter; Burlando, Paolo

2016-04-01

A new weather generator, AWE-GEN-2d (Advanced WEather GENerator for 2-Dimension grid) is developed following the philosophy of combining physical and stochastic approaches to simulate meteorological variables at high spatial and temporal resolution (e.g. 2 km x 2 km and 5 min for precipitation and cloud cover and 100 m x 100 m and 1 h for other variables variable (temperature, solar radiation, vapor pressure, atmospheric pressure and near-surface wind). The model is suitable to investigate the impacts of climate variability, temporal and spatial resolutions of forcing on hydrological, ecological, agricultural and geomorphological impacts studies. Using appropriate parameterization the model can be used in the context of climate change. Here we present the model technical structure of AWE-GEN-2d, which is a substantial evolution of four preceding models (i) the hourly-point scale Advanced WEather GENerator (AWE-GEN) presented by Fatichi et al. (2011, Adv. Water Resour.) (ii) the Space-Time Realizations of Areal Precipitation (STREAP) model introduced by Paschalis et al. (2013, Water Resour. Res.), (iii) the High-Resolution Synoptically conditioned Weather Generator developed by Peleg and Morin (2014, Water Resour. Res.), and (iv) the Wind-field Interpolation by Non Divergent Schemes presented by Burlando et al. (2007, Boundary-Layer Meteorol.). The AWE-GEN-2d is relatively parsimonious in terms of computational demand and allows generating many stochastic realizations of current and projected climates in an efficient way. An example of model application and testing is presented with reference to a case study in the Wallis region, a complex orography terrain in the Swiss Alps.

Becoming Curt Lemay: The Formative Experiences of an Air Force Icon

DTIC Science & Technology

2011-06-01

Turbulent Life of General Curtis LeMay some 20 years after LeMay‟s autobiographical piece. Laced with an apologetic undertone, Iron Eagle is insufficiently...to radio her position around midnight. The three B- 59 “ Memories of Gen. LeMay,” San Antonio

JPRS Report, East Europe

DTIC Science & Technology

1991-07-15

that are of any ideological signi- fance and likely to evoke hostile attitudes against the Army should be eliminated as soon as possible, [passage...of the Gen - eral Staff of the Polish Armed Forces, within a structure reflected in the chart, will amount to about 1,200 positions for career

Plant-endophytes interaction influences the secondary metabolism in Echinacea purpurea (L.) Moench: an in vitro model.

PubMed

Maggini, Valentina; De Leo, Marinella; Mengoni, Alessio; Gallo, Eugenia Rosaria; Miceli, Elisangela; Reidel, Rose Vanessa Bandeira; Biffi, Sauro; Pistelli, Luisa; Fani, Renato; Firenzuoli, Fabio; Bogani, Patrizia

2017-12-05

The influence of the interaction(s) between the medicinal plant Echinacea purpurea (L.) Moench and its endophytic communities on the production of alkamides is investigated. To mimic the in vivo conditions, we have set up an infection model of axenic in vitro E. purpurea plants inoculated with a pool of bacterial strains isolated from the E. purpurea stems and leaves. Here we show different alkamide levels between control (not-inoculated) and inoculated plants, suggesting that the alkamide biosynthesis may be modulated by the bacterial infection. Then, we have analysed the branched-chain amino acids (BCCA) decarboxylase gene (GenBank Accession #LT593930; the enzymatic source for the amine moiety formation of the alkamides) expression patterns. The expression profile shows a higher expression level in the inoculated E. purpurea tissues than in the control ones. These results suggest that the plant-endophyte interaction can influence plant secondary metabolism affecting the therapeutic properties of E. purpurea.

The History of Wargaming

DTIC Science & Technology

2008-03-10

Wargaming 1811 - Herr von Reisswitz - a base of sand 1824 - Lt Reisswitz - the expanding circle - Offsite - Brain Storming - Wargame - Exercise...innovation 1980s O-Plan Development Wargaming - The Gulf War  US  Iraqi - Soviet method for ground forces - a reason for the halt - US software...talk” to each other Fewer, more Joint “engines” JSIMS, JWARS “Expanded” Use: Congressional Liaison Procurement Decisions Tactics Development

Remote Performance Monitoring of a Thermoplastic Composite Bridge at Camp Mackall, NC

DTIC Science & Technology

2011-11-01

level, flow, creep, and force for slope stability, subsidence, seismicity studies, structural restoration, or site assessment applications. • Mining ...monitors mine ventilation, slope stability, convergence, and equipment performance. • Machinery testing- provides temperature, pressure, RPM, veloci...Contact an Applications Engineer for help in deter- mining the best antenna for your application. • 21831 0 dBd, ’l.t Wave Dipole Whip Antenna

A Quantitative Model for Assessing Visual Simulation Software Architecture

DTIC Science & Technology

2011-09-01

Software Engineering Arnold Buss Research Associate Professor of MOVES LtCol Jeff Boleng, PhD Associate Professor of Computer Science U.S. Air Force Academy... science (operating and programming systems series). New York, NY, USA: Elsevier Science Ltd. Henry, S., & Kafura, D. (1984). The evaluation of software...Rudy Darken Professor of Computer Science Dissertation Supervisor Ted Lewis Professor of Computer Science Richard Riehle Professor of Practice

Exploring New Concepts for Joint Urban Operations

DTIC Science & Technology

2003-08-01

Services, and Department of Defense organizations. We would like to ex- press our appreciation to the following: Mr. Mike Collins, Arlington County ...Larry D. Budge, USA (Ret.), JAWP–IDA MG Waldo Freeman, USA (Ret.), Strategy, Forces & Research Division, IDA COL Michael Barron, USA, JAWP–IDA Lt Col...Adaptive Red Team (DART) from Science Applica- tions International Corporation. The Arlington County (Virginia) Police, Fire, and Utilities De

Marshall Space Flight Center Black History Month Program

NASA Image and Video Library

2018-02-21

The Black History Month program was presented at Marshall Space Flight Center with guest speaker Lt. General Stayce Harris. General Harris is the Inspector General of the Air Force and she is the first African American female Lieutenant General in the American military. The topic of her presentation was "African Americans in Times of War". The presentation was followed by an ethnic food sampling.

An Analysis of the Effectiveness of Air Force Information Management Officer Training Based on the Perceived Needs of Current Information Management Officers

DTIC Science & Technology

1992-12-01

proper perspective. Finally, I wish to thank my thesis advisors , Lt Col John Huguley Jr. and Dr Ben Williams. Together they made a most supportive and...Microcomputer System Implementation in Small Businesses," Journal of Systems Management 41:7-9 (June 1990). 35. Schrage, Michael. "Meet the Robo -Boss

Popularity of Russian information sources of medical education.

PubMed

Vasilyeva, Irina V; Arseniev, Sergey B

2014-01-01

The aim of the present study is to analyze the popularity of information sources of medical educational sites <webmedinfo.ru>, medical information portal <meduniver.com>, medical portal for students <6years.net>, electronic library of medical literature <booksmed.com>, <medliter.ru> and <medbook.net.ru>. Three sites (<www.webmedinfo.ru>, <meduniver.com> and <6years.net>) provide sources of medical literature, educational videos, medical histories, medical papers and medical popular literature. And three other sites (<www.booksmed.com>, <www.medliter.ru> and <www.medbook.net.ru>) provide sources for electronic medical books on various subjects. Using on-line programs Alexa and Cy-pr we have analyzed the website's rating and identified the main data and time-varying data of the sites. Calculated Alexa Rank rating was determined for each site. Our study has shown that the most popular information sources of medical education among the six studied sites for Russian users is <meduniver.com>; the site <booksmed.com> is at the second place referring to the Alexa Rank rating and the site <webmedinfo.ru> is at the second place referring to the citation index in Yandex. The most popular medical site of electronic medical books is <booksmed.com>.

Machinability of drilling T700/LT-03A carbon fiber reinforced plastic (CFRP) composite laminates using candle stick drill and multi-facet drill

NASA Astrophysics Data System (ADS)

Wang, Cheng-Dong; Qiu, Kun-Xian; Chen, Ming; Cai, Xiao-Jiang

2015-03-01

Carbon Fiber Reinforced Plastic (CFRP) composite laminates are widely used in aerospace and aircraft structural components due to their superior properties. However, they are regarded as difficult-to-cut materials because of bad surface quality and low productivity. Drilling is the most common hole making process for CFRP composite laminates and drilling induced delamination damage usually occurs severely at the exit side of drilling holes, which strongly deteriorate holes quality. In this work, the candle stick drill and multi-facet drill are employed to evaluate the machinability of drilling T700/LT-03A CFRP composite laminates in terms of thrust force, delamination, holes diameter and holes surface roughness. S/N ratio is used to characterize the thrust force while an ellipse-shaped delamination model is established to quantitatively analyze the delamination. The best combination of drilling parameters are determined by full consideration of S/N ratios of thrust force and the delamination. The results indicate that candle stick drill will induce the unexpected ellipse-shaped delamination even at its best drilling parameters of spindle speed of 10,000 rpm and feed rate of 0.004 mm/tooth. However, the multi-facet drill cutting at the relative lower feed rate of 0.004 mm/tooth and lower spindle speed of 6000 rpm can effectively prevent the delamination. Comprehensively, holes quality obtained by multi-facet drill is much more superior to those obtained by candle stick drill.

Infrared nanoscopy down to liquid helium temperatures

NASA Astrophysics Data System (ADS)

Lang, Denny; Döring, Jonathan; Nörenberg, Tobias; Butykai, Ádám; Kézsmárki, István; Schneider, Harald; Winnerl, Stephan; Helm, Manfred; Kehr, Susanne C.; Eng, Lukas M.

2018-03-01

We introduce a scattering-type scanning near-field infrared microscope (s-SNIM) for the local scale near-field sample analysis and spectroscopy from room temperature down to liquid helium (LHe) temperature. The extension of s-SNIM down to T = 5 K is in particular crucial for low-temperature phase transitions, e.g., for the examination of superconductors, as well as low energy excitations. The low temperature (LT) s-SNIM performance is tested with CO2-IR excitation at T = 7 K using a bare Au reference and a structured Si/SiO2-sample. Furthermore, we quantify the impact of local laser heating under the s-SNIM tip apex by monitoring the light-induced ferroelectric-to-paraelectric phase transition of the skyrmion-hosting multiferroic material GaV4S8 at Tc = 42 K. We apply LT s-SNIM to study the spectral response of GaV4S8 and its lateral domain structure in the ferroelectric phase by the mid-IR to THz free-electron laser-light source FELBE at the Helmholtz-Zentrum Dresden-Rossendorf, Germany. Notably, our s-SNIM is based on a non-contact atomic force microscope (AFM) and thus can be complemented in situ by various other AFM techniques, such as topography profiling, piezo-response force microscopy (PFM), and/or Kelvin-probe force microscopy (KPFM). The combination of these methods supports the comprehensive study of the mutual interplay in the topographic, electronic, and optical properties of surfaces from room temperature down to 5 K.

REGION-WIDE GENETIC STRUCTURE OF THE CENTRAL STONEROLLER (CAMPOSTOMA ANOMALUM) AND THE RELATIONSHIP OF GENETIC DIVERSITY TO ENVIRONMENTAL QUALITY

EPA Science Inventory

Anthropogenic stressors that reduce population size, alter migration corridors or modify mutational and selective forces on populations are expected to leave a lasting genetic footprint on the distribution of intraspecific genetic variation. Thus, the pattern of intraspecific gen...

Pressure-induced structural change in liquid GeI₄.

PubMed

Fuchizaki, Kazuhiro; Nishimura, Hironori; Hase, Takaki; Saitoh, Hiroyuki

2017-12-13

The similarity in the shape of the melting curve of GeI₄ to that of SnI₄ suggests that a liquid-liquid transition as observed in liquid SnI₄ is also expected to occur in liquid GeI₄. Because the slope of the melting curve of GeI₄ abruptly changes at around 3 GPa, in situ synchrotron diffraction measurements were conducted to examine closely the structural changes upon compression at around 3 GPa. The reduced radial distribution functions of the high- and low-pressure liquid states of GeI₄ share the same feature inherent in the high-pressure (high-density) and low-pressure (low-density) radial distribution functions of liquid SnI₄. This feature allows us to introduce local order parameters that we may use to observe the transition. Unlike the transition in liquid SnI₄, the transition from the low-pressure to the high-pressure structure seems sluggish. We speculate that the liquid-liquid critical point of GeI₄ is no longer a thermodynamically stable state and is slightly located below the melting curve. As a result, the structural change is said to be a crossover rather than a transition. The behavior of the local-order parameters implies a metastable extension of the liquid-liquid phase boundary with a negative slope. . © 2017 IOP Publishing Ltd.

Magnetotransport study of topological superconductor Cu_0.10Bi₂Se₃ single crystal.

PubMed

Li, Mingtao; Fang, Yifei; Zhang, Jincang; Yi, Hemian; Zhou, Xingjiang; Lin, Chengtian

2018-02-02

We report a magnetotransport study of vortex-pinning in Cu_0.10Bi₂Se₃ single crystal. The sample is demonstrated to be in clean limit and absent of Pauli spin-limiting effect. Interestingly, the resistivity versus magnetic field shows an anomalously pronounced increase when approaching the superconducting-normal state boundary for both B∥ab and B∥c configurations. We have investigated the flux-flowing behavior under various magnetic field and temperatures, enabling us to establish its anisotropic vortex phase diagram. Our results suggest the Cu_0.10Bi₂Se₃ can be served as one unique material for exploring exotic surface vortex states in topological superconductors. © 2018 IOP Publishing Ltd.

Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene.

PubMed

Mason, H S; Haq, T A; Clements, J D; Arntzen, C J

1998-08-01

The authors have designed and constructed a plant-optimize synthetic gene encoding the Escherichia coli heat-labile enterotoxin B subunit (LT-B), for use in transgenic plants as an edible vaccine against enterotoxigenic E. coli. Expression of the synthetic LT-B gene in potato plants under the control of a constitutive promoter yielded increased accumulation of LT-B in leaves and tubers, as compared to the bacterial LT-B gene. The plant-derived LT-B assembled into native pentameric structures as evidenced by its ability to bind ganglioside. The authors demonstrated immunogenicity by feeding mice the raw tubers and comparing the anti-LT-B serum IgG and faecal IgA to that produced in mice gavaged with bacterial LT-B. Mice were fed three weekly doses of 5 g tuber tissue containing either 20 or 50 micrograms LT-B, or gavaged weekly with 5 micrograms of LT-B from recombinant E. coli. One week after the third dose, mice immunized with potato LT-B had higher levels of serum and mucosal anti-LT-B than those gavaged with bacterial LT-B. Mice were challenged by oral administration of 25 micrograms LT, and protection assessed by comparing the gut/carcass mass ratios. Although none of the mice were completely protected, the higher dose potato vaccine compared favourably with the bacterial vaccine. These findings show that an edible vaccine against E. coli LT-B is feasible.

Creech Blue: Gen Bill Creech and the Reformation of the Tactical Air Forces, 1978-1984

DTIC Science & Technology

2004-10-01

formation that, in large measure, built the Air Force that has fought so brilliantly in campaigns from Operation Desert Storm to the present global war...than eight years for LeMay and more than six for Creech. In LeMay’s case , it was the Strategic Air Command (SAC) during its formative years, when...nuclear weapons, bombers, and intercontinental ballistic missiles were the order of the day. In Creech’s case , it was TAC during the post-Vietnam defense

Win, Learn, Focus, Adapt, Win Again: The Scrimmage Should be as Hard as the Game

DTIC Science & Technology

2011-03-01

prepare us for what lies ahead only if, as GEN Gorman put it, “forceful, effective ideas on how to fight pervade the force.” We know how to fight to- day...and policies to develop leaders who can effectively op- erate in a much more transpar- ent, complex and decentralized February 2011 � ARMY 25... effectiveness of our leader-development programs against clearly defined tasks, conditions and stan- dards. What I’m suggesting here, however, is that

A History of the Army Ground Forces; Study Number 16. The Army Ground Forces History of the Second Army

DTIC Science & Technology

1945-09-01

proficiency in conjunction with other arms and services.7 GHQ and Second Army placed great stress on the development of instructors and the proper training of...separate units. This was clearly brought out in a report of iuspection of Second Army units at Ft. Knox, Ky., by Maj. Gen. J. M. Cumins , Commander of the...covered were food and water, hygiene, housing, field sanitation, and contagious and communicable diseases. Physical exercise stressed mass calisthenics

Understanding and Misunderstanding the Use of Deadly Force Policy Among Air Force Security Police Personnel

DTIC Science & Technology

1988-05-01

less than happy with parts of the ROE. Also, a commander in chief Central Command staff officer told me that Gen. George C . Crist was not happy with...the Committee on Armed Services traveled to the Persian Gulf to interview Stark’s crew members. The members, Les Aspin, Bill Nichols, and William ...first hit. (7:32) Admiral Sharp did, however, find fault with the ship’s tactical action officer, Lieutenant Basil E. Moncrief , Jr. "who had been

Organizational Dysfunction in the US Air Force: Lessons from the ICBM Community

DTIC Science & Technology

2016-06-01

separated the space and missile career fields, highlighting a need to produce career professionals in the ICBM community.12 During this time, errors...raises for missileers,” Air Force Times 74, no. 29 (27 Jan, 2014): 10. 20 Gen Martin Dempsey, “America’s Military – A Profession of Arms.” Washington...Bullying”, 18-20; Cynthia Coccia, "Avoiding a "Toxic" Organization," Nursing Management 29, no. 5 (May 1998): 32; Janie Fritz. “Organizational Misbehavior

A Review of the Army’s Modular Force Structure

DTIC Science & Technology

2011-01-01

was a subsequent desire by then–U.S. Army Chief of Staff (CSA, 1999–2003) Gen- eral Eric K. Shinseki for a responsive, mobile, midweight (that is...validation. The objective stage, during which implementation of the force would occur, was set to begin in 2005.15 When General Eric K. Shinseki became...Force—A Relevant Concept? Ft. Leavenworth, Kan.: School of Advanced Military Studies, April 1999, pp. 12–13. 16 General Eric K. Shinseki, U.S. Army

Polyethylene Glycol Camouflaged Earthworm Hemoglobin.

PubMed

Jani, Vivek P; Jelvani, Alborz; Moges, Selamawit; Nacharaju, Parimala; Roche, Camille; Dantsker, David; Palmer, Andre; Friedman, Joel M; Cabrales, Pedro

2017-01-01

Nearly 21 million components of blood and whole blood and transfused annually in the United States, while on average only 13.6 million units of blood are donated. As the demand for Red Blood Cells (RBCs) continues to increase due to the aging population, this deficit will be more significant. Despite decades of research to develop hemoglobin (Hb) based oxygen (O2) carriers (HBOCs) as RBC substitutes, there are no products approved for clinical use. Lumbricus terrestris erythrocruorin (LtEc) is the large acellular O2 carrying protein complex found in the earthworm Lumbricus terrestris. LtEc is an extremely stable protein complex, resistant to autoxidation, and capable of transporting O2 to tissue when transfused into mammals. These characteristics render LtEc a promising candidate for the development of the next generation HBOCs. LtEc has a short half-life in circulation, limiting its application as a bridge over days, until blood became available. Conjugation with polyethylene glycol (PEG-LtEc) can extend LtEc circulation time. This study explores PEG-LtEc pharmacokinetics and pharmacodynamics. To study PEG-LtEc pharmacokinetics, hamsters instrumented with the dorsal window chamber were subjected to a 40% exchange transfusion with 10 g/dL PEG-LtEc or LtEc and followed for 48 hours. To study the vascular response of PEG-LtEc, hamsters instrumented with the dorsal window chamber received multiple infusions of 10 g/dL PEG-LtEc or LtEc solution to increase plasma LtEc concentration to 0.5, then 1.0, and 1.5 g/dL, while monitoring the animals' systemic and microcirculatory parameters. Results confirm that PEGylation of LtEc increases its circulation time, extending the half-life to 70 hours, 4 times longer than that of unPEGylated LtEc. However, PEGylation increased the rate of LtEc oxidation in vivo. Vascular analysis verified that PEG-LtEc showed the absence of microvascular vasoconstriction or systemic hypertension. The molecular size of PEG-LtEc did not change the colloid osmotic pressure or blood volume expansion capacity compared to LtEc, due to LtEc's already large molecular size. Taken together, these results further encourage the development of PEG-LtEc as an O2 carrying therapeutic.

Chilling and cooking rate effects on some myofibrillar determinants of tenderness of beef.

PubMed

King, D A; Dikeman, M E; Wheeler, T L; Kastner, C L; Koohmaraie, M

2003-06-01

Our objectives were to examine the effects of prerigor excision and rapid chilling vs. conventional carcass chilling of two muscles on proteolysis and tenderness during the postmortem storage, as well as the effects of fast and slow rates of cooking on myofibrillar characteristics and tenderness. The longissimus thoracis (LT) and triceps brachii (TB), long head muscles were removed 45 min after exsanguination from the left side of 12 carcasses and chilled in an ice bath to induce cold shortening (excised, rapidly chilled). At 24 h postmortem, the corresponding muscles were removed from the right side (conventionally chilled). All muscles were cut into 2.54-cm-thick steaks and assigned to one of two postmortem times (1 or 14 d), and to raw and cooking treatments. Steaks were cooked at 260 degrees C (FAST) or 93 degrees C (SLOW) in a forced-air convection oven to an internal temperature of 70 degrees C. Cooking loss, cooking time, and Warner-Bratzler shear force (WBSF) were measured on cooked steaks. Sarcomere length (SL) and the extent of proteolysis of desmin were measured on raw and cooked steaks. As expected, the excised, rapidly chilled muscles had a much more rapid (P < 0.05) temperature decline than those that were conventionally chilled. The excised, rapidly chilled treatment resulted in shorter (P < 0.05) SL, and SL was shorter (P < 0.05) in LT than in TB steaks. Raw steaks had longer (P < 0.05) SL than cooked steaks, regardless of chilling treatment. The FAST cooking resulted in shorter (P < 0.05) SL than SLOW cooking in conventionally chilled steaks, but cooking rate had no effect (P > 0.05) on SL of rapidly chilled steaks. Generally, TB steaks required longer (P < 0.05) cooking times and had higher (P < 0.05) cooking losses than LT steaks, and FAST-cooked steaks had greater (P < 0.05) cooking losses than SLOW-cooked steaks. Rapidly chilled steaks had less (P < 0.05) degradation of desmin than conventionally chilled steaks (31 vs. 41%). Aging for 14 d increased (P < 0.05) desmin degradation. Rapid chilling of muscles resulted in much higher (P < 0.05) WBSF values, whereas aging resulted in lower (P < 0.05) WBSF values. The SLOW-cooked TB steaks were more tender (P < 0.05) than FAST-cooked TB steaks and LT steaks cooked at either rate. Excised, rapidly chilled muscles underwent proteolysis, but it occurred at a slower rate during the first 24 h postmortem than it did in conventionally chilled muscles. Cooking rate did not affect tenderness of LT steaks, but SLOW cooking resulted in more tender TB steaks.

Room temperature synthesis of ReS₂ through aqueous perrhenate sulfidation.

PubMed

Borowiec, Joanna; Gillin, William P; Willis, Maureen; Boi, Filippo; He, Yi; Wen, Jiqiu; Wang, Shanling; Schulz, Leander

2017-12-29

In this study, a direct sulfidation reaction of ammonium perrhenate (NH₄ReO₄) leading to a synthesis of rhenium disulfide (ReS₂) is demonstrated. These finding reveal the first example of a simplistic bottom-up approach to the chemical synthesis of crystalline ReS₂. The reaction presented here takes place at room temperature, in an ambient and solvent-free environment and without the necessity of a catalyst. The atomic composition and structure of the as-synthesized product were characterized using several analysis techniques including energy dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), transmission electron microscopy (TEM), Raman spectroscopy, thermogravimetric analysis (TGA) and differential scannig calorimetry (DSC). The results indicated the formation of a lower symmetry (1T_d) ReS₂ with a low degree of layer stacking. © 2017 IOP Publishing Ltd.

Spring 2008 Industry Study. Privatized Military Operations Industry

DTIC Science & Technology

2008-01-01

Department of Defense Civilian Lt Col Nathan “ Chili ” Lindsay, United States Air Force COL Darius Lukowski, Polish Army Ms. Diane Meyer, Department...efforts of the USG. Recommendations This Liberia case study demonstrates the benefits and costs of using contractors for the execution of U.S...PMFs and the USG to explore innovative ways to partner such that both parties would benefit by identifying requirements and capabilities in a more

Air Force Academy Aeronautics Digest - Spring/Summer 1982.

DTIC Science & Technology

1983-03-01

Ben Rich, discusses the philosophy of advanced aircraft design and development that has made the "Skunk Works" so successful. Editorial Review by Capt...This Digest has been reviewed and is approved for publication. Thomas E. McCann, Lt. Colonel, USAF Director of Research and Continuing Education... review . Our thanks also to Associate Editor, Martha Arends, and Production Artist, Deborah Ross, of Contract Techical Services, Inc. *The first eight

CAD/CAM Preparation Design Effects on Endodontically Treated and Restored Molars

DTIC Science & Technology

2016-05-24

ii APPROVED: Col Drew W . Fallis Dean, Air Force Postgraduate Dental School iii Acknowledgements Special thanks to Col Howard Roberts, Maj...excerpts, is with the permission of the copyright owner. Signature AARON T. DANCB. MAJ. USAF, DC v Printed Name USAF Postgraduate Dental School Keesler...internal amalgam-dentin 3 interface. Preparations were accomplished by one operator using a high speed electric dental hand piece (EA-SlLT, Adee

A Summary of the Naval Postgraduate School Research Programs and Recent Publications.

DTIC Science & Technology

1991-09-01

publication by the ASNE accepted on an international basis as an effective Naval Engineering Journal after final editing, means of reducing ship roll...Teleoperator," SUMMARY: A non-anthropomorphic, force International Journal of Robotics and Autlonomouts reflecting telemanipulator was procured in FY91...and From 22-24 May 1991. Centrifugal Instabilities," International Journal of Heat and Fluid Flow, forthcoming. THESES DIRECTED: Hughes, R.E., LT, USN

US Air Force 1989 Research Initiation Program . Volume 1.

DTIC Science & Technology

1992-06-25

microbial ecology of contaminated soils. 27-5 Thomas and coworkers (1989) studied microbial activity at a creosote waste site and demonstrated that...provide information essential for an understanding of the microbial ecology of contaminated soils, they do not address the microbiology of...substrates. Appl. Environ. Microbiol. 49:711-713. Thomas, J. M., M. D. Lee, M. J. Scott and C. H. Ward. 1989. Microbial ecology of the subsurface Lt an

Maintainer’s Associate Training Instructional Environment: Its Demonstration (MATIE 2)

DTIC Science & Technology

1989-06-01

Force Human Resources Laboratory, Brooks AFB, Texas for their support. We would especially like to thank Capt Kevin Kline, Lt Col Hugh Bums, and Mr...impossible. Thus, technicians need to be able to augment general understanding through use of technical documentation when automiated diagnostic systems...34 which incorporate human -like knowledge of three types: procedural, declarative, and qualitative. Procedural knowledge is that which Is required to

The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines.

PubMed

Paul, N L; Millet, I; Ruddle, N H

1993-07-01

The HTLV-I transcriptional activator tax was used to gain insight into the mechanism of lymphotoxin (LT; TNF-beta) gene induction. Tax-expressing cell lines produce LT biologic activity. An LT promoter (LT-293) CAT construct that contained an NF-kappa B site was active in the LT-producing C81-66-45 cell line, which contains defective HTLV-I but expresses tax. The observation that a mutated LT-kappa B construct (M1-CAT) was inactive in C81-66-45, confirmed the importance of NF-kappa B in LT gene expression. Tax was transfected into HTLV-I-negative human T-cell lines. Jurkat T cells stably expressing tax contained elevated levels of NF-kappa B that directly bound to the LT-kappa B site. Tax co-transfected with reporter constructs into Jurkat cells maximally activated HTLV-I-LTR-CAT and kappa B-fos-CAT and also activated LT-293 to a lesser extent. In JM T cells, tax induced LT-293 activity by two- to four-fold, though there was no induction of M1-CAT. The increase in LT-293 CAT activity mirrored the increase in LT biologic activity seen under these conditions. These studies, the first to demonstrate induction of LT promoter activity over basal levels, indicate that HTLV-I tax causes low-level activation of both endogenous LT and the LT promoter, at least in part through activation of NF-kappa B.

Nutrient loads exported from managed catchments reveal emergent biogeochemical stationarity

NASA Astrophysics Data System (ADS)

Basu, Nandita B.; Destouni, Georgia; Jawitz, James W.; Thompson, Sally E.; Loukinova, Natalia V.; Darracq, Amélie; Zanardo, Stefano; Yaeger, Mary; Sivapalan, Murugesu; Rinaldo, Andrea; Rao, P. Suresh C.

2010-12-01

Complexity of heterogeneous catchments poses challenges in predicting biogeochemical responses to human alterations and stochastic hydro-climatic drivers. Human interferences and climate change may have contributed to the demise of hydrologic stationarity, but our synthesis of a large body of observational data suggests that anthropogenic impacts have also resulted in the emergence of effective biogeochemical stationarity in managed catchments. Long-term monitoring data from the Mississippi-Atchafalaya River Basin (MARB) and the Baltic Sea Drainage Basin (BSDB) reveal that inter-annual variations in loads (LT) for total-N (TN) and total-P (TP), exported from a catchment are dominantly controlled by discharge (QT) leading inevitably to temporal invariance of the annual, flow-weighted concentration, $\\overline{Cf = (LT/QT). Emergence of this consistent pattern across diverse managed catchments is attributed to the anthropogenic legacy of accumulated nutrient sources generating memory, similar to ubiquitously present sources for geogenic constituents that also exhibit a linear LT-QT relationship. These responses are characteristic of transport-limited systems. In contrast, in the absence of legacy sources in less-managed catchments, $\\overline{Cf values were highly variable and supply limited. We offer a theoretical explanation for the observed patterns at the event scale, and extend it to consider the stochastic nature of rainfall/flow patterns at annual scales. Our analysis suggests that: (1) expected inter-annual variations in LT can be robustly predicted given discharge variations arising from hydro-climatic or anthropogenic forcing, and (2) water-quality problems in receiving inland and coastal waters would persist until the accumulated storages of nutrients have been substantially depleted. The finding has notable implications on catchment management to mitigate adverse water-quality impacts, and on acceleration of global biogeochemical cycles.

Safety of Direct-Acting Antiviral Therapy Regarding Renal Function in Post-Liver Transplant Patients Infected with Hepatitis C Virus and a 100% 12-Week Sustained Virologic Response-A Single-Center Study.

PubMed

Peschel, G; Moleda, L; Baier, L; Selgrad, M; Schmid, S; Scherer, M N; Müller, M; Weigand, K

2018-06-01

Patients after liver transplantation (LT) with hepatitis C virus (HCV) infection often suffer from renal or hepatic impairment. Treating patients after LT with direct-acting antivirals (DAA) might result in decreasing renal function due to interaction of DAA and immunosuppressive therapy. In this single-center study we analyzed clinical parameters of 18 HCV-infected patients treated with DAA therapy after LT. The primary end points were change of renal function (glomerular filtration rate) and sustained virologic response 12 weeks after therapy (SVR12). For secondary end points, we investigated the influence of DAA therapy on transaminases, bilirubin, international normalized ratio, noninvasive fibrosis measurement, and Model for End-Stage Liver Disease (MELD) score. Five out of 18 patients treated with DAA suffered from renal impairment stage 2, and 7 patients of renal impairment stage 3. Renal function at SVR12 was not influenced by preexisting renal impairment (P > .5), type of immunosuppressant (P > .5), or type of DAA regimen (P > .5). All patients reached SVR12. The levels of transaminases and bilirubin declined rapidly, as expected. Ten out of 18 patients already suffered from cirrhosis or liver fibrosis >F3 according to noninvasive measurement before initiation of treatment. Single-point acoustic radiation force impulse imaging improved in 9 patients (P = .012). In 7 patients, MELD score improved owing to the decrease of bilirubin levels. In 6 patients it worsened. DAA therapy in LT patients was effective and safe in this single-center real-life cohort. Renal function was not influenced by the administered drug combinations, even in patients with preexisting renal impairment. Copyright © 2018. Published by Elsevier Inc.

IR technology for enhanced force protection by AIM

NASA Astrophysics Data System (ADS)

Breiter, R.; Ihle, T.; Rode, W.; Wendler, J.; Rühlich, I.; Haiml, M.; Ziegler, J.

2008-04-01

In all recent missions our forces are faced with various types of asymmetric threads like snipers, IEDs, RPGs or MANPADS. 2 nd and 3 rd Gen IR technology is a backbone of modern force protection by providing situational awareness and accurate target engagement at day/night. 3 rd Gen sensors are developed for thread warning capabilities by use of spectral or spatial information. The progress on a dual-color IR module is discussed in a separate paper [1]. A 1024x256 SWIR array with flexure bearing compressor and pulse tube cold finger provides > 50,000h lifetime for space or airborne hyperspectral imaging in pushbroom geometry with 256 spectral channels for improved change detection and remote sensing of IEDs or chemical agents. Similar concepts are pursued in the LWIR with either spectroscopic imaging or a system of LWIR FPA combined with a cooled tunable Laser to do spectroscopy with stimulated absorption of specific wavelengths. AIM introduced the RangIR sight to match the requirements of sniper teams, AGLs and weapon stations, extending the outstanding optronic performance of the fielded HuntIR with position data of a target by a laser range finder (LRF), a 3 axis digital magnetic compass (DMC) and a ballistic computer for accurate engagement of remote targets. A version with flexure bearing cooler with >30,000h life time is being developed for continuous operation in e.g. gunfire detection systems. This paper gives an overview of AIM's technologies for enhanced force protection.

Operational Reservations: Considerations for a Total Army Force

DTIC Science & Technology

2014-06-01

individually proficient. To answer some of the questions about the viabil- ity of a 5-year training cycle for RC units, Major Gen- eral Tim Orr, the Adjutant...resident school). 85. “Structured Self-Development,” Ft. Bliss , TX: U.S. Army Sergeants Major Academy, available from https://usasma.bliss. army.mil

Screening the molecular targets of ovarian cancer based on bioinformatics analysis.

PubMed

Du, Lei; Qian, Xiaolei; Dai, Chenyang; Wang, Lihua; Huang, Ding; Wang, Shuying; Shen, Xiaowei

2015-01-01

Ovarian cancer (OC) is the most lethal gynecologic malignancy. This study aims to explore the molecular mechanisms of OC and identify potential molecular targets for OC treatment. Microarray gene expression data (GSE14407) including 12 normal ovarian surface epithelia samples and 12 OC epithelia samples were downloaded from Gene Expression Omnibus database. Differentially expressed genes (DEGs) between 2 kinds of ovarian tissue were identified by using limma package in R language (|log2 fold change| gt;1 and false discovery rate [FDR] lt;0.05). Protein-protein interactions (PPIs) and known OC-related genes were screened from COXPRESdb and GenBank database, respectively. Furthermore, PPI network of top 10 upregulated DEGs and top 10 downregulated DEGs was constructed and visualized through Cytoscape software. Finally, for the genes involved in PPI network, functional enrichment analysis was performed by using DAVID (FDR lt;0.05). In total, 1136 DEGs were identified, including 544 downregulated and 592 upregulated DEGs. Then, PPI network was constructed, and DEGs CDKN2A, MUC1, OGN, ZIC1, SOX17, and TFAP2A interacted with known OC-related genes CDK4, EGFR/JUN, SRC, CLI1, CTNNB1, and TP53, respectively. Moreover, functions about oxygen transport and embryonic development were enriched by the genes involved in the network of downregulated DEGs. We propose that 4 DEGs (OGN, ZIC1, SOX17, and TFAP2A) and 2 functions (oxygen transport and embryonic development) might play a role in the development of OC. These 4 DEGs and known OC-related genes might serve as therapeutic targets for OC. Further studies are required to validate these predictions.

Comparison of a field-based test to estimate functional threshold power and power output at lactate threshold.

PubMed

Gavin, Timothy P; Van Meter, Jessica B; Brophy, Patricia M; Dubis, Gabriel S; Potts, Katlin N; Hickner, Robert C

2012-02-01

It has been proposed that field-based tests (FT) used to estimate functional threshold power (FTP) result in power output (PO) equivalent to PO at lactate threshold (LT). However, anecdotal evidence from regional cycling teams tested for LT in our laboratory suggested that PO at LT underestimated FTP. It was hypothesized that estimated FTP is not equivalent to PO at LT. The LT and estimated FTP were measured in 7 trained male competitive cyclists (VO2max = 65.3 ± 1.6 ml O2·kg(-1)·min(-1)). The FTP was estimated from an 8-minute FT and compared with PO at LT using 2 methods; LT(Δ1), a 1 mmol·L(-1) or greater rise in blood lactate in response to an increase in workload and LT(4.0), blood lactate of 4.0 mmol·L(-1). The estimated FTP was equivalent to PO at LT(4.0) and greater than PO at LT(Δ1). VO2max explained 93% of the variance in individual PO during the 8-minute FT. When the 8-minute FT PO was expressed relative to maximal PO from the VO2max test (individual exercise performance), VO2max explained 64% of the variance in individual exercise performance. The PO at LT was not related to 8-minute FT PO. In conclusion, FTP estimated from an 8-minute FT is equivalent to PO at LT if LT(4.0) is used but is not equivalent for all methods of LT determination including LT(Δ1).

The role of liver transplantation for congenital extrahepatic portosystemic shunt.

PubMed

Sakamoto, Seisuke; Shigeta, Takanobu; Fukuda, Akinari; Tanaka, Hideaki; Nakazawa, Atsuko; Nosaka, Shunsuke; Uemoto, Shinji; Kasahara, Mureo

2012-06-27

Congenital extrahepatic portosystemic shunt (CEPS) is reported more frequently because of advances in imaging techniques. Liver transplantation (LT) is a therapeutic option, although the indications for LT are still controversial. This study reviewed 34 cases of LT for CEPS, including 30 cases reported in the English medical literature and the patients treated in our department, to collect the clinical data associated with LT. The median age at diagnosis and LT was 3.7 and 6.8 years, respectively. Hepatic encephalopathy, including persistent hyperammonemia, was the most common indication of LT. Pulmonary complications, including hepatopulmonary syndrome and pulmonary hypertension, were the second most common indications of LT, and those patients underwent LT soon after the diagnosis. Although a shunt directly draining into the inferior vena cava was the most common type and managed by a simple direct anastomosis of the portal vein at LT, some cases required the modification of the portal vein reconstruction, such as interposition. Thirty patients were alive with a median follow-up period of 18 months. LT for CEPS showed an excellent outcome. The development of pulmonary complications is an early indication for LT. Precise planning of portal vein reconstruction is required before LT.

Evidence for the Confinement of Magnetic Monopoles in Quantum Spin Ice.

PubMed

Sarte, Paul Maximo; Aczel, Adam; Ehlers, Georg; Stock, Christopher; Gaulin, Bruce D; Mauws, Cole; Stone, Matthew B; Calder, Stuart; Nagler, Stephen; Hollett, Joshua; Zhou, Haidong; Gardner, Jason S; Attfield, J Paul; Wiebe, Christopher R

2017-09-25

Magnetic monopoles are hypothesised elementary particles connected by Dirac strings that behave like infinitely thin solenoids [Dirac 1931 Proc. Roy. Soc. A 133 60]. Despite decades of searches, free magnetic monopoles and their Dirac strings have eluded experimental detection, although there is substantial evidence for deconfined magnetic monopole quasiparticles in spin ice materials [Castelnovo, Moessner & Sondhi 2008 Nature 326 411]. Here we report the detection of a hierarchy of unequally-spaced magnetic excitations via high resolution inelastic neutron spectroscopic measurements on the quantum spin ice candidate Pr₂Sn₂O₇. These excitations are well-described by a simple model of monopole pairs bound by a linear potential [Coldea et al. Science 327 177] with an effective tension of 0.7(1) K/Angstrom. The success of the linear potential model suggests that these low energy magnetic excitations are direct spectroscopic evidence for the confinement of magnetic monopole quasiparticles in the quantum spin ice candidate Pr₂Sn₂O₇. © 2017 IOP Publishing Ltd.

Landau theory for magnetic and structural transitions in CeCo_0.85Fe_0.15Si.

PubMed

Carreras, William Gabriel; Correa, Víctor Félix; Sereni, Julian G; García, Daniel J; Cornaglia, Pablo S

2018-06-05

We present a phenomenological analysis of the magnetoelastic properties of CeCo_0.85Fe_0.15Si at temperatures close to the Néel transition temperature T_N. Using a Landau functional we provide a qualitative description of the thermal expansion, magnetostriction, magnetization and specific heat data. We show that the available experimental results [Journal of Physics: Condensed Matter <b>28</b> 346003 (2016)] are consistent with the presence of a structural transition at T_s≧ T_N and a strong magnetoelastic coupling. The magnetoelastic coupling presents a Janus-faced effect: while the structural transition is shifted to higher temperatures as the magnetic field is increased, the resulting striction at low temperatures decreases. The strong magnetoelastic coupling and the proximity of the structural transition to the onset temperature for magnetic fluctuations, suggest that the transition could be an analogue of the tetragonal to orthorhombic observed in Fe-based pcnictides. . © 2018 IOP Publishing Ltd.

Liver transplant modulates gut microbial dysbiosis and cognitive function in cirrhosis.

PubMed

Bajaj, Jasmohan S; Fagan, Andrew; Sikaroodi, Masoumeh; White, Melanie B; Sterling, Richard K; Gilles, HoChong; Heuman, Douglas; Stravitz, Richard T; Matherly, Scott C; Siddiqui, Mohammed S; Puri, Puneet; Sanyal, Arun J; Luketic, Velimir; John, Binu; Fuchs, Michael; Ahluwalia, Vishwadeep; Gillevet, Patrick M

2017-07-01

Liver transplantation (LT) improves daily function and cognition in patients with cirrhosis, but a subset of patients can remain impaired. Unfavorable microbiota or dysbiosis is observed in patients with cirrhosis, but the effect of LT on microbial composition, especially with poor post-LT cognition, is unclear. The aims were to determine the effect of LT on gut microbiota and to determine whether gut microbiota are associated with cognitive dysfunction after LT. We enrolled outpatient patients with cirrhosis on the LT list and followed them until 6 months after LT. Cognition (Psychometric Hepatic Encephalopathy score [PHES]), health-related quality of life (HRQOL), and stool microbiota (multitagged sequencing for diversity and taxa) tests were performed at both visits. Persistent cognitive impairment was defined as a stable/worsening PHES. Both pre-/post-LT data were compared with age-matched healthy controls. We enrolled 45 patients (56 ± 7 years, Model for End-Stage Liver Disease score 26 ± 8). They received LT 6 ± 3 months after enrollment and were re-evaluated 7 ± 2 months after LT with a stable course. A significantly improved HRQOL, PHES, with increase in microbial diversity, increase in autochthonous, and decrease in potentially pathogenic taxa were seen after LT compared with baseline. However, there was continued dysbiosis and HRQOL/cognitive impairment after LT compared with controls in 29% who did not improve PHES after LT. In these, Proteobacteria relative abundance was significantly higher and Firmicutes were lower after LT, whereas the reverse occurred in the group that improved. Delta PHES was negatively correlated with delta Proteobacteria and positively with delta Firmicutes. In conclusion, LT improves gut microbiota diversity and dysbiosis compared with pre-LT baseline but residual dysbiosis remains compared with controls. There is cognitive and HRQOL enhancement in general after LT, but a higher Proteobacteria relative abundance change is associated with posttransplant cognitive impairment. Liver Transplantation 23 907-914 2017 AASLD. © 2017 by the American Association for the Study of Liver Diseases.

Lung Transplantation for Cystic Fibrosis: Results, Indications, Complications, and Controversies

PubMed Central

Lynch, Joseph P.; Sayah, David M.; Belperio, John A.; Weigt, S. Sam

2016-01-01

Survival in patients with cystic fibrosis (CF) has improved dramatically over the past 30 to 40 years, with mean survival now approximately 40 years. Nonetheless, progressive respiratory insufficiency remains the major cause of mortality in CF patients, and lung transplantation (LT) is eventually required. Timing of listing for LT is critical, because up to 25 to 41% of CF patients have died while awaiting LT. Globally, approximately 16.4% of lung transplants are performed in adults with CF. Survival rates for LT recipients with CF are superior to other indications, yet LT is associated with substantial morbidity and mortality (~50% at 5-year survival rates). Myriad complications of LT include allograft failure (acute or chronic), opportunistic infections, and complications of chronic immunosuppressive medications (including malignancy). Determining which patients are candidates for LT is difficult, and survival benefit remains uncertain. In this review, we discuss when LT should be considered, criteria for identifying candidates, contraindications to LT, results post-LT, and specific complications that may be associated with LT. Infectious complications that may complicate CF (particularly Burkholderia cepacia spp., opportunistic fungi, and nontuberculous mycobacteria) are discussed. PMID:25826595

KSC-08pd3592

NASA Image and Video Library

2008-11-07

CAPE CANAVERAL, Fla. – Standing next to a Starfighter aircraft at the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida, retired U.S. Air Force Lt. Col. Lee A. Archer Jr., one of the Tuskegee Airmen, shares his experiences as a combat fighter pilot. Earlier, Archer made a special presentation to the Kennedy work force, talking about his years as a combat fighter pilot, civil rights leader and business executive. Archer is the only Tuskegee Airmen fighter pilot to receive the honor “Ace” for shooting down five enemy aircraft during WWII. He retired as Air Force Command Pilot after 30 years of military service, 1941-1971. Archer is at Kennedy to serve as Military Marshall of the 2008 KSC Space & Air Show, Nov. 8-9. Photo credit: NASA/Kim Shiflett

Heart-rate variability and training-intensity distribution in elite rowers.

PubMed

Plews, Daniel J; Laursen, Paul B; Kilding, Andrew E; Buchheit, Martin

2014-11-01

Elite endurance athletes may train in a polarized fashion, such that their training-intensity distribution preserves autonomic balance. However, field data supporting this are limited. The authors examined the relationship between heart-rate variability and training-intensity distribution in 9 elite rowers during the 26-wk build-up to the 2012 Olympic Games (2 won gold and 2 won bronze medals). Weekly averaged log-transformed square root of the mean sum of the squared differences between R-R intervals (Ln rMSSD) was examined, with respect to changes in total training time (TTT) and training time below the first lactate threshold (LT(2). Correlations (± 90% confidence limits) for Ln rMSSD were small vs TTT (r = .37 ± .80), moderate vs time LT2 (r = -.22 ± .50). These data provide supportive rationale for the polarized model of training, showing that training phases with increased time spent at high intensity suppress parasympathetic activity, while low-intensity training preserves and increases it. As such, periodized low-intensity training may be beneficial for optimal training programming.

A Harmonized Physiologically Based Pharmacokinetic Model for Nonane as a Component of Jet Fuel

DTIC Science & Technology

2007-09-16

96-C-9010). Lt Col Terry A. Childress served as Contract Officer Representative for the U.S. Air Force, Armstrong Laboratory, Toxicology Division...fibers and solvents. These values are being used by Dr. Subhash Basak (University of Minnesota, personal communication) for 44 hierarchical QSAR ...that they exist individually at very low concentrations, and they are of no particular toxicological concern in themselves. It is not worth

The Benefits of Completing Homework for Students with Different Aptitudes in an Introductory Electricity and Magnetism Course

DTIC Science & Technology

2015-02-17

this study, course exams were used to measure student learning rather than research -based concept tests like the Force Concept Inventory [ 19), the...Release Information: This art icles has been accepted by Physical Review Special Topics -- Physics Education Research fo r publication. Previous...portraying official policy. II signed // MONTE D. ANDERSON, Lt Col, USAF Deputy Department Head for Research Department of Physics Tabs 1

Testing of DentStat (trademark) and Competing Dental Materials

DTIC Science & Technology

2014-06-13

NAVAL MEDICAL RESEARCH UNIT SAN ANTONIO TESTING OF DENTST AT™ AND COMPETING DENTAL MATERIALS Y OON HWANG PHD, JONATHAN STAHL DDS PHD, WAYNE M. D...LtCOL Wen Lien of the US Air Force Dental Evaluation and Consultation Service for assistance with the strength testing. 1 Reviewed and Approved by...direct dental repair materials. They are made of calcium or strontium aluminofluoro-silicate glass powder (base) combined with a water-soluble polymer

Deliberate and Crisis Action Planning and Execution Segments Increment 2B (DCAPES Inc 2B)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Deliberate and Crisis Action Planning and Execution Segments Increment 2B (DCAPES Inc 2B...Defense Acquisition Management Information Retrieval (DAMIR) UNCLASSIFIED DCAPES Inc 2B 2016 MAR UNCLASSIFIED 2 Table of Contents Common...Logistics DCAPES Inc 2B 2016 MAR UNCLASSIFIED 3 Lt Col Christopher Thrower 201 East Moore Drive Building 856, Room 154 Maxwell Air Force Base-Gunter

Future Role for Women in the Armed Forces

DTIC Science & Technology

1976-11-18

American vil Liberties Union Women’s Ri s Project .INVOCAT . ......... ....................... C Ch aplain (Captain) Lorraine Potter, USAF, Pease AFB...Patricia Beyea, Project Coordinator for Women’s ( Rights Project, American Civil Liberties Union , spoke about "Concern for Equality of Opportunities for...LtC Mary J. Hale, USMC 2 2 .A-2 I ( " I’ : MEMBERS OF THE PJBLIC IN ATTENDANCE Ms. Patricia Beyea, The American Civil Liberties Union Ms. Kathleen

The Capabilities Gap in Desert Storm: A Coalition Air Campaign Case Study

DTIC Science & Technology

2001-06-01

Vallance , �Royal Air Force Operations in the Gulf,� Air Power History, Fall 1991, 37. 68 LtCol David Deptula, Chief Planner, CENTAF Special Planning Group...70 Evans, Jagaur, 127. 71 Vallance , 37. 72 The air launched anti-radiation missile (ALARM) was...similar to the US HARM. 73 Vallance , 37. 74 An interesting side note was that since these Tornados were planned to fly from German bases to stem a

CACDA Jiffy War Game Technical Manual. Part 1: Methodology

DTIC Science & Technology

1977-03-01

Systems Analysis Office (Mr Tyburski) Fort Monmout’.h, NJ 07703 Commander 1* USAISD ATTN: ATISE-TD-TS-CD (LT Boyer) Fort Deven , MASS 01433 Commander 2...Developments Activity Fort Leavenworth, Kansas 66027 CACDA JIFFY WAR GAME TECHNICAL MANUAL Part 1: Methodology by Timothy J. Bailey and Gerald A. Martin ACN...ComrbatDevelopments Activity (CACDA), Fort Leavenworth,i-Xsas," for scenario devel- opment and force structure evaluation. The Jiffy Game computer

Air & Space Power Journal. Volume 26, Number 5. September-October 2012

DTIC Science & Technology

2012-10-01

of their air support through variations in doctrine or expansion of available options to meet the mission requirements. Envisioning mul­...Alfred Goldberg and Lt Col Donald Smith, Army–Air Force Relations: The Close Air Support Issue, R-906-PR (Santa Monica, CA: RAND, October 1971), 16...most impor­ tant near term priority” and recognizing it as “the most effective way to generate capacity, increase tempo , [and achieve] maximum

Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors.

PubMed

Maekawa, Akiko; Kanaoka, Yoshihide; Xing, Wei; Austen, K Frank

2008-10-28

The cysteinyl leukotrienes (cys-LTs) are a family of potent lipid mediators of inflammation derived from arachidonic acid. Activation of certain cell types results in the biosynthesis and export of leukotriene (LT) C(4), which then undergoes extracellular metabolism to LTD(4) and LTE(4). LTE(4), the most stable cys-LT, is only a weak agonist for the defined type 1 and type 2 cys-LT receptors (CysLT(1)R and CysLT(2)R, respectively). We had recognized a greater potency for LTE(4) than LTC(4) or LTD(4) in constricting guinea pig trachea in vitro and comparable activity in eliciting a cutaneous wheal and flare response in humans. Thus, we hypothesized that a vascular permeability response to LTE(4) in mice lacking both the CysLT(1)R and CysLT(2)R could establish the existence of a separate LTE(4) receptor. We now report that the intradermal injection of LTE(4) into the ear of mice deficient in both CysLT(1)R and CysLT(2)R elicits a vascular leak that exceeds the response to intradermal injection of LTC(4) or LTD(4), and that this response is inhibited by pretreatment of the mice with pertussis toxin or a Rho kinase inhibitor. LTE(4) is approximately 64-fold more potent in the CysLT(1)R/CysLT(2)R double-deficient mice than in sufficient mice. The administration of a CysLT(1)R antagonist augmented the permeability response of the CysLT(1)R/CysLT(2)R double-deficient mice to LTC(4), LTD(4), and LTE(4). Our findings establish the existence of a third receptor, CysLT(E)R, that responds preferentially to LTE(4), the most abundant cys-LT in biologic fluids, and thus reveal a new target for therapeutic intervention.

Re-assessing accumulated oxygen deficit in middle-distance runners.

PubMed

Bickham, D; Le Rossignol, P; Gibbons, C; Russell, A P

2002-12-01

The purpose of this study was to re-assess the accumulated oxygen deficit (AOD), incorporating recent methodological improvements i.e., 4 min submaximal tests spread above and below the lactate threshold (LT). We Investigated the Influence of the VO2 -speed regression, on the precision of the estimated total energy demand and AOD. utilising different numbers of regression points and including measurement errors. Seven trained middle-distance runners (mean +/- SD age: 25.3 +/- 5.4y, mass: 73.7 +/- 4.3kg. VO2max 64.4 +/- 6.1 mL x kg(-1) x min(-1)) completed a VO2max, LT, 10 x 4 min exercise tests (above and below LT) and high-intensity exhaustive tests. The VO2 -speed regression was developed using 10 submaximal points and a forced y-intercept value. The average precision (measured as the width of 95% confidence Interval) for the estimated total energy demand using this regression was 7.8mL O2 Eq x kg(-1) x min(-1). There was a two-fold decrease in precision of estimated total energy demand with the Inclusion of measurement errors from the metabolic system. The mean AOD value was 43.3 mL O2 Eq x kg(-1) (upper and lower 95% CI 32.1 and 54.5mL o2 Eq x kg(-1) respectively). Converting the 95% CI for estimated total energy demand to AOD or including maximum possible measurement errors amplified the error associated with the estimated total energy demand. No significant difference in AOD variables were found, using 10,4 or 2 regression points with a forced y-intercept. For practical purposes we recommend the use of 4 submaximal values with a y-intercept. Using 95% CIs and calculating error highlighted possible error in estimating AOD. Without accurate data collection, increased variability could decrease the accuracy of the AOD as shown by a 95% CI of the AOD.

Maglev Launch: Ultra-low Cost, Ultra-high Volume Access to Space for Cargo and Humans

NASA Astrophysics Data System (ADS)

Powell, James; Maise, George; Rather, John

2010-01-01

Despite decades of efforts to reduce rocket launch costs, improvements are marginal. Launch cost to LEO for cargo is ~$10,000 per kg of payload, and to higher orbit and beyond much greater. Human access to the ISS costs $20 million for a single passenger. Unless launch costs are greatly reduced, large scale commercial use and human exploration of the solar system will not occur. A new approach for ultra low cost access to space-Maglev Launch-magnetically accelerates levitated spacecraft to orbital speeds, 8 km/sec or more, in evacuated tunnels on the surface, using Maglev technology like that operating in Japan for high speed passenger transport. The cost of electric energy to reach orbital speed is less than $1 per kilogram of payload. Two Maglev launch systems are described, the Gen-1System for unmanned cargo craft to orbit and Gen-2, for large-scale access of human to space. Magnetically levitated and propelled Gen-1 cargo craft accelerate in a 100 kilometer long evacuated tunnel, entering the atmosphere at the tunnel exit, which is located in high altitude terrain (~5000 meters) through an electrically powered ``MHD Window'' that prevents outside air from flowing into the tunnel. The Gen-1 cargo craft then coasts upwards to space where a small rocket burn, ~0.5 km/sec establishes, the final orbit. The Gen-1 reference design launches a 40 ton, 2 meter diameter spacecraft with 35 tons of payload. At 12 launches per day, a single Gen-1 facility could launch 150,000 tons annually. Using present costs for tunneling, superconductors, cryogenic equipment, materials, etc., the projected construction cost for the Gen-1 facility is 20 billion dollars. Amortization cost, plus Spacecraft and O&M costs, total $43 per kg of payload. For polar orbit launches, sites exist in Alaska, Russia, and China. For equatorial orbit launches, sites exist in the Andes and Africa. With funding, the Gen-1 system could operate by 2020 AD. The Gen-2 system requires more advanced technology. Passenger spacecraft enter the atmosphere at 70,000 feet, where deceleration is acceptable. A levitated evacuated launch tube is used, with the levitation force generated by magnetic interaction between superconducting cables on the levitated launch tube and superconducting cables on the ground beneath. The Gen-2 system could launch 100's of thousands of passengers per year, and operate by 2030 AD. Maglev launch will enable large human scale exploration of space, thousands of gigawatts of space solar power satellites for beamed power to Earth, a robust defense against asteroids and comets, and many other applications not possible now.

Obama Kennedy Space Center Visit

NASA Image and Video Library

2010-04-14

Gen. C. Robert Kehler, Commander, Air Force Space Command, left, NASA Deputy Administrator Lori Garver, 2nd from left, NASA Kennedy Space Center Director Bob Cabana, and Col. Burke E. Wilson is the Commander, 45th Space Wing, right, welcome the arrival of Air Force One and President Barack Obama to the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)

Recommendations for treatment of hypothyroidism with levothyroxine and levotriiodothyronine: a 2016 position statement of the Italian Society of Endocrinology and the Italian Thyroid Association.

PubMed

Biondi, B; Bartalena, L; Chiovato, L; Lenzi, A; Mariotti, S; Pacini, F; Pontecorvi, A; Vitti, P; Trimarchi, F

2016-12-01

Levothyroxine (L-T4) is recommended as lifelong replacement therapy for hypothyroidism. Recent clinical and experimental data support the addition of levotriiodothyronine (L-T3) treatment in some selected hypothyroid patients when their symptoms persist and their quality of life remains impaired despite adequate L-T4 monotherapy. An increase in L-T3 prescriptions has been recently observed in Italy due to availability of different L-T3 formulations, making it possible to clinicians to prescribe L-T3 alone or in combination with L-T4. The aim of the present position statement was to define the correct clinical indications, schedule, duration of treatment and contraindications of combined treatment with L-T4 and L-T3 in hypothyroid patients in an attempt to guide clinicians and to avoid potential adverse effects of overtreatment.

Functional expression of cysteinyl leukotriene receptors on human platelets.

PubMed

Hasegawa, Shunji; Ichiyama, Takashi; Hashimoto, Kunio; Suzuki, Yasuo; Hirano, Reiji; Fukano, Reiji; Furukawa, Susumu

2010-01-01

Normal peripheral blood leukocytes, such as basophils, eosinophils, B lymphocytes and monocytes/macrophages, have a cysteinyl leukotriene 1 (CysLT1) receptor, while the cysteinyl leukotriene 2 (CysLT2) receptor is expressed in cardiac Purkinje cells, endothelium, brain and leukocytes. However, it is unknown whether or not platelets express the CysLT1 or CysLT2 receptor. In this study we identify and characterize the biological function of the CysLT receptor of human platelets. We determined the CysLT1 or CysLT2 receptor mRNA expression in normal human platelets by RT-PCR and determined protein expression by Western blotting and flow cytometry. Moreover, we examined the effect of cysteinyl leukotrienes (CysLTs) in platelets on the induction of RANTES (Regulated on Activation, Normal T Expressed, and presumably Secreted). We also investigated whether the CysLT1 receptor antagonist pranlukast inhibits CysLT-induced RANTES release. In conclusion, we showed the functional expression of CysLT receptors on human platelets and demonstrated that CysLTs induced the release of significant amounts of RANTES, which suggests a novel role for human platelets in CysLT-mediated allergic inflammation.

Lung transplantation for cystic fibrosis: results, indications, complications, and controversies.

PubMed

Lynch, Joseph P; Sayah, David M; Belperio, John A; Weigt, S Sam

2015-04-01

Survival in patients with cystic fibrosis (CF) has improved dramatically over the past 30 to 40 years, with mean survival now approximately 40 years. Nonetheless, progressive respiratory insufficiency remains the major cause of mortality in CF patients, and lung transplantation (LT) is eventually required. Timing of listing for LT is critical, because up to 25 to 41% of CF patients have died while awaiting LT. Globally, approximately 16.4% of lung transplants are performed in adults with CF. Survival rates for LT recipients with CF are superior to other indications, yet LT is associated with substantial morbidity and mortality (∼50% at 5-year survival rates). Myriad complications of LT include allograft failure (acute or chronic), opportunistic infections, and complications of chronic immunosuppressive medications (including malignancy). Determining which patients are candidates for LT is difficult, and survival benefit remains uncertain. In this review, we discuss when LT should be considered, criteria for identifying candidates, contraindications to LT, results post-LT, and specific complications that may be associated with LT. Infectious complications that may complicate CF (particularly Burkholderia cepacia spp., opportunistic fungi, and nontuberculous mycobacteria) are discussed. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Safety and efficacy of E coli enterotoxin adjuvant for urease-based rectal immunization against Helicobacter pylori.

PubMed

Sougioultzis, Stavros; Lee, Cynthia K; Alsahli, Mazen; Banerjee, Subhas; Cadoz, Michel; Schrader, Robert; Guy, Bruno; Bedford, Philip; Monath, Thomas P; Kelly, Ciaran P; Michetti, Pierre

2002-12-13

Low dose E. coli heat-labile enterotoxin (LT), delivered orally or enterically, has been used as an adjuvant for Helicobacter pylori (H. pylori) urease in healthy adults. In this study we aim to test the safety and adjuvant efficacy of LT delivered rectally together with recombinant H. pylori urease. Eighteen healthy adults without present or past H. pylori infection were enrolled in a double blind, randomized, ascending dose study to receive either urease (60 mg), or urease (60 mg) + LT (5 or 25 microg). The immunization preparation was administered per rectum on days 0, 14 and 28. Serum, stool and saliva anti-urease and anti-LT IgG and IgA antibodies (Abs) were measured and urease-specific and LT-specific antigen secreting cells (ASCs) were counted in peripheral blood at baseline and 7 (ASC counts) or 14 days (antibody levels) after each dosing. Peripheral blood lymphoproliferation assays were also performed at baseline and at the end of the study. Rectally delivered urease and LT were well tolerated. Among the 12 subjects assigned to urease+LT, 2 (16.7%) developed anti-urease IgG Abs, 1 (8.3%) developed anti-urease IgA Abs, and 3 (25%) showed urease-specific IgA(+) ASCs. Immune responses to LT were more vigorous, especially in subjects exposed to 5 microg LT. In the urease+ 5 microg LT group, anti-LT IgG and IgA Abs developed in 60 and 80% of the subjects, respectively, while LT-specific IgG(+) and IgA(+) ASCs were detected in all subjects. The magnitude of the anti-LT response was much higher than the response to urease. No IgA anti-urease or anti-LT Abs were detected in stool or saliva and lymphocyte proliferative responses to urease were unsatisfactory. In conclusion, rectal delivery of 5 microg LT is safe and induces vigorous systemic anti-LT immune responses. Further studies are needed to determine if LT can be an effective adjuvant for rectally delivered antigens.

Training Intensity Distribution Over a Four-Year Cycle in Olympic Champion Rowers: Different Roads Lead to Rio.

PubMed

Plews, Daniel J; Laursen, Paul B

2017-09-27

The purpose of this study was to compare the training intensity distribution (TID) of the undefeated world champion male rowing New Zealand (kiwi) pair over a four-year Olympic cycle, across training phases, training years, and between individuals. Training data, including heart rate and boat speed, were recorded in the athletes rowing in the same boat between March 2013 and August 2016, ending with the Rio Olympics final. Progressive exercise tests assessed first (LT 1 ) and second (LT 2 ) lactate thresholds and associated heart rates, to determine the percentage of training performed below, between and above these demarcation points. Training an average of only 12-15 h/wk throughout the Olympic cycle, the mean percent distribution of time (±SD) at each training intensity was 80.4 ± 5.5% LT 2 for Rower A and 67.3 ± 9.0% LT 2 for Rower B. Across the years 2014-2016, Rower A performed most likely more training

Gender, personality, and serotonin-2A receptor binding in healthy subjects

PubMed Central

Soloff, Paul H.; Price, Julie C.; Mason, Neale Scott; Becker, Carl; Meltzer, Carolyn C.

2009-01-01

The vulnerability to mood disorders, impulsive-aggression, eating disorders, and suicidal behavior varies greatly with gender, and may reflect gender differences in central serotonergic function. We investigated the relationships of gender, mood, impulsivity, aggression and temperament to 5HT2A receptor binding in 21 healthy subjects using [18F]altanserin and PET neuro-imaging. Binding potentials in pre-defined Regions of Interest (ROI) were calculated using the Logan graphical method, corrected for partial volume effects, and compared by gender with age co-varied. SPM analysis was used for voxel level comparisons. Altanserin binding (BPp) was greater in male than female subjects in 9 ROIs: hippocampus (HIP) and Lt. HIP, lateral orbital frontal cortex (LOF) and Lt.LOF, left medial frontal cortex (Lt.MFC), left medial temporal cortex (Lt. MTC), left occipital cortex (Lt. OCC), thalamus (THL) and Lt. THL. Differences in Lt. HIP and Lt. MTL remained significant after Bonferroni correction. Gender differences were noted in the co-variation of psychological traits with BPp values in specific ROIs. Among males alone, aggression was negatively correlated with BPp values in Lt. LOF and Lt. MFC, and Suspiciousness positively correlated in LOF, Lt. LOF and Lt. MFC. Among female subjects alone, Negativism was positively correlated with BPp values in HIP, and Verbal Hostility in Lt. HIP. Altanserin binding in Lt. MTC was positively correlated with Persistence, with no significant gender effect. Gender differences in 5HT2A receptor function in specific ROIs may mediate expression of psychological characteristics such as aggression, suspiciousness and negativism. Future studies of 5HT2A receptor function and its relationship to behavior should control for gender. PMID:19959344

Comparison of microdosimetry-based absorbed doses to control tumours and clinically obtained tumour absorbed doses in treatments with ²²³Ra.

PubMed

Minguez Gabina, Pablo; Roeske, John C; Mínguez, Ricardo; Gomez de Iturriaga, Alfonso; Rodeño, Emilia

2018-06-20

We performed Monte Carlo simulations in order to determine by means of microdosimetry calculations the average number of hits to the cell nucleus required to reach a tumour control probability (TCP) of 0.9, 〈n_0.9 〉, for the source geometry of a nucleus embedded in a homogeneous distribution of ²²³Ra atoms. From the results obtained and following the MIRD methodology, we determined the values of lesion absorbed doses needed to reach a TCP of 0.9, D_0.9, for different values of mass density, cell radiosensitivity, nucleus radius and lesion volume. The greatest variation of those absorbed doses occurred with cell radiosensitivity and no dependence was found on mass density. The source geometry used was chosen because we aimed to compare the values of D_0.9 with the lesion absorbed doses obtained from image-based macrodosimetry in treatments of metastatic castration-resistant prostate cancer with ²²³Ra which were obtained assuming a homogeneous distribution of ²²³Ra atoms within the lesion. In a comparison with a study including 29 lesions, results showed that even for the case of the most radiosensitive cells simulated, 45% of the lesions treated following a schedule of two cycles of 110 kBq/kg body mass would receive absorbed doses below the values of D_0.9 determined in this study. © 2018 Institute of Physics and Engineering in Medicine.

Joint Chiefs of Staff > Media > News

Science.gov Websites

Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management Readout of Chairman of the Joint Chiefs of Staff Gen. Dunford's Meeting with Chief of the Turkish General

Gen. Paul J. Selva > Joint Chiefs of Staff > Article View

Science.gov Websites

aircraft systems and executive officer, Deputy Chief of Staff, Plans and Resources, Headquarters Strategic Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management

Spaceport Super Safety and Health Day

NASA Image and Video Library

2003-10-15

Brig. Gen. J. Gregory Pavlovich (left), 45th Space Wing, and Center Director Jim Kennedy (right) present one of several individual safety awards given on Spaceport Super Safety and Health Day. An annual event at KSC and Cape Canaveral Air Force Station, Spaceport Super Safety and Health Day is dedicated to reinforcing safe and healthful behaviors in the workforce.

Information Warfare: An Air Force Policy for the Role of Public Affairs

DTIC Science & Technology

1996-06-01

munitions. — Albert Camus An Option Two role for PA would entail proactive management of the news. PA does this now, but it does not admit it, and...existed or not.14 But, like Wash­ ington, generals were not beyond using the press to sow their own seeds of disinformation. Confederate Gen Albert

Rhombohedral R3c to orthorhombic Pnma phase transition induced by Y-doping in BiFeO₃.

PubMed

Graf, Monica Elisabet; Di Napoli, Solange; Barral, Maria Andrea Andrea; Saleh Medina, Leila; Negri, R Martín; Sepliarsky, Marcelo; Llois, Ana María

2018-05-23

In this work we study, by means of <i>ab initio</i> calculations, the structural, electronic and magnetic properties of Y-doped BiFeO₃ compounds. We determine that there is a morphotropic phase boundary at an yttrium concentration of (18 ± 2)%, where the structure changes from <i>R3c</i> to <i>Pnma</i>. This structural transition is driven by the chemical pressure induced by the dopant. By analyzing the evolution of the oxygen octahedral tilts we find an enhanced antiferrodistortive distortion when increasing the Y-doping, together with a reduction of the ferroelectric distorsion, that gives rise to a smaller value of the electric polarization. These cooperative effects should lead to a larger canting of the Fe magnetic moments and to a larger ferromagnetic response in the <i>R3c</i> phase, as it is observed in the experiments. . © 2018 IOP Publishing Ltd.

Oral immunisation of naive and primed animals with transgenic potato tubers expressing LT-B.

PubMed

Lauterslager, T G; Florack, D E; van der Wal, T J; Molthoff, J W; Langeveld, J P; Bosch, D; Boersma, W J; Hilgers, L A

2001-03-21

The efficacy of edible vaccines produced in potato tubers was examined in mice. Transgenic plants were developed by Agrobacterium tumefaciens-mediated transformation. The antigen selected was the non-toxic B subunit of the Escherichia coli enterotoxin (recLT-B). A synthetic gene coding for recLT-B was made and optimised for expression in potato tubers and accumulation in the endoplasmic reticulum. Introduction of this gene under control of the tuber-specific patatin promoter in potato plants resulted in the production of functional, i.e. Gm1-binding, recLT-B pentamers in tubers. Selected tubers containing about 13 microg of recLT-B per gram fresh weight were used for immunisation. Subcutaneous immunisation with an extract of recLT-B tubers yielded high antibody titres in serum that were similar to those obtained with bacterial recLT-B. The efficacy of oral administration of recLT-B tubers was determined by measuring mucosal and systemic immune responses in naive and primed mice. Animals were primed by subcutaneous injection of an extract of recLT-B tuber plus adjuvant. Naive and primed mice were fed 5 g of tubers ( approximately 65 microg of recLT-B) or were intubated intragastrically with 0.4 ml of tuber extract ( approximately 2 microg of recLT-B). In naive mice, feeding recLT-B tubers or intubation of tuber extract did not induce detectable anti-LT antibody titres. In primed animals, however, oral immunisation resulted in significant anti-LT IgA antibody responses in serum and faeces. Intragastric intubation of tuber extract revealed higher responses than feeding of tubers. These results indicate clearly that functional recLT-B can be produced in potato tubers, that this recombinant protein is immunogenic and that oral administration thereof elicits both systemic and local IgA responses in parentally primed, but not naive, animals.

Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine.

PubMed

Celi, Francesco S; Zemskova, Marina; Linderman, Joyce D; Smith, Sheila; Drinkard, Bart; Sachdev, Vandana; Skarulis, Monica C; Kozlosky, Merel; Csako, Gyorgy; Costello, Rene; Pucino, Frank

2011-11-01

Levothyroxine (L-T(4)) therapy is based on the assumption that the conversion of T(4) into T(3) provides adequate amounts of active hormone at target tissues. However, in rodents, L-T(4) alone does not restore a euthyroid state in all tissues. Previous combination L-T(4)/liothyronine (L-T(3)) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action. Our objective was to evaluate the efficacy of thyroid hormone replacement with L-T(4) or L-T(3) at doses producing equivalent normalization of TSH. Fourteen hypothyroid patients participated in this randomized, double-blind, crossover intervention at the National Institutes of Health Clinical Center. L-T(3) or L-T(4) were administered thrice daily to achieve a target TSH from 0.5-1.5 mU/liter. Volunteers were studied as inpatients after 6 wk on a stable dose and at the target TSH. Serum thyroid hormones, lipid parameters, and indices of glucose metabolism were evaluated. No difference was observed in TSH between L-T(3) and L-T(4) treatments. L-T(3) resulted in significant weight loss [L-T(4), 70.6 ± 12.5, vs. L-T(3), 68.5 ± 11.9 kg (P = 0.009)] and in a 10.9 ± 10.0% decrease in total cholesterol (P = 0.002), 13.3 ± 12.1% decrease in low-density lipoprotein-cholesterol (P = 0.002), and an 18.3 ± 28.6% decrease in apolipoprotein B (P = 0.018). No significant differences were observed in high-density lipoprotein-cholesterol, heart rate, blood pressure, exercise tolerance, or insulin sensitivity. The substitution of L-T(3) for L-T(4) at equivalent doses (relative to the pituitary) reduced body weight and resulted in greater thyroid hormone action on the lipid metabolism, without detected differences in cardiovascular function or insulin sensitivity.

Immunological Interrelationships Between Cholera Toxin and the Heat-Labile and Heat-Stable Enterotoxins of Coliform Bacteria

PubMed Central

Klipstein, Frederick A.; Engert, Richard F.

1977-01-01

Cholera toxin (CT) and the heat-labile (LT) toxin of Escherichia coli are known to share antigenic properties. The present study examined the immunological relationship of CT and the LT and heat-stable (ST) toxins of E. coli, Klebsiella pneumoniae, and Enterobacter cloacae. The neutralizing capacity of equine CT antiserum and of antiserum raised in rabbits to the LT toxin of the three species of coliform bacteria was evaluated by determining their capacity to inhibit the action of purified CT and semipurified ultrafiltration preparations of the coliform LT and ST toxins in inducing water secretion as assayed by the in vivo marker perfusion technique in the rat jejunum. One milliliter of antiserum to CT and to E. coli and Klebsiella LT completely neutralized the secretory action of each of these three toxins; effective serial dilutions of CT antiserum extended to 1 to 4, whereas those of the antisera to LT were limited to 1 to 2 in most instances. One milliliter of antiserum to E. cloacae LT partially neutralized each of the three coliform LT toxins; serial dilutions were inactive. Antiserum to E. cloacae LT did not neutralize CT. Antiserum to CT and to each of the three coliform LT toxins also had a weak neutralizing effect on the ST toxins of E. coli and Klebsiella, but they did not affect E. cloacae ST. Adsorption of the antiserum to CT and to each of the three LT toxins by incubation with a heat-inactivated preparation of either the homologous or a heterologous LT toxin completely abolished the neutralizing capacity of the antisera towards both LT and ST. These observations indicate that the immunological interrelationship of CT and E. coli LT extends to the LT toxins of Klebsiella and E. cloacae and, further, that these immunological properties are shared to a lesser extent by the ST toxins of E. coli and Klebsiella. PMID:332637

Modulation of the atmospheric quasi-biweekly oscillation on the diurnal variation of the occurrence frequency of the Tibetan Plateau vortices

NASA Astrophysics Data System (ADS)

Li, Lun; Zhang, Renhe; Wen, Min

2018-06-01

In this study, modulation of the atmospheric quasi-biweekly oscillation (QBWO) on diurnal variation of the occurrence frequency of Tibetan Plateau vortices (TPVs) during May-August of 2000-2009 was investigated. The diurnal variations of the occurrence frequency of the TPVs (OFTPVs) and the related dynamic and thermodynamic features in the positive and negative phases of QBWO were compared. In both the positive and negative phases, the OFTPVs reaches the maximum from evening to midnight (18-00 LT, LT indicates the local time), and minimum from early morning to noon (06-12 LT). At 18 LT, there is strongest convergence at 500 hPa and ascending motion, as well as the most abundant net water vapor budget over the Tibetan Plateau, which is in favor of the precipitation and the related condensation latent heat release, corresponding to the maximum of OFTPVs in 18-00 LT. On the contrary, in the early morning at 06 LT, the conditions are most unfavorable for genesis of TPVs in 06-12 LT. QBWO leads to stronger convergence at 500 hPa, ascending motion as well as more massive water vapor in the positive phases than those in the negative phases, resulting in larger numbers of TPVs occur in all of the four periods of a day (00-06 LT, 06-12 LT, 12-18 LT, and 18-00 LT) in the former. The TPVs generating from the early morning to noon (06-12 LT) are weaker and more sensitive and fragile to the disadvantageous background, while the TPVs occurring from evening to midnight (18-00 LT) are stronger and seem to be well tolerated, leading to more remarkable contrast between the OFTPVs in the negative and positive phases in 06-12 LT than in 18-00 LT.

Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

PubMed

Shultz, L D; Schweitzer, P A; Christianson, S W; Gott, B; Schweitzer, I B; Tennent, B; McKenna, S; Mobraaten, L; Rajan, T V; Greiner, D L

1995-01-01

The scid mutation was backcrossed ten generations onto the NOD/Lt strain background, resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive as well as nonadaptive immunologic function. NOD/LtSz-scid/scid mice lack functional lymphoid cells and show little or no serum Ig with age. Although NOD/(Lt-)+/+ mice develop T cell-mediated autoimmune, insulin-dependent diabetes mellitus, NOD/LtSz-scid/scid mice are both insulitis- and diabetes-free throughout life. However, because of a high incidence of thymic lymphomas, the mean lifespan of this congenic stock is only 8.5 mo under specific pathogen-free conditions. After i.v. injection of human CEM T-lymphoblastoid cells, splenic engraftment of these cells was fourfold greater in NOD/LtSz-scid/scid mice than in C.B17/Sz-scid/scid mice. Although C.B-17Sz-scid/scid mice exhibit robust NK cell activity, this activity is markedly reduced in both NOD/(Lt-)+/+ and NOD/LtSz-scid/scid mice. Presence of a functionally less mature macrophage population in NOD/LtSz-scid/scid vs C.B-17Sz-scid/scid mice is indicated by persistence in the former of the NOD/Lt strain-specific defect in LPS-stimulated IL-1 secretion by marrow-derived macrophages. Although C.B-17Sz-scid/scid and C57BL/6Sz-scid/scid mice have elevated serum hemolytic complement activity compared with their respective +/+ controls, both NOD/(LtSz-)+/+ and NOD/LtSz-scid/scid mice lack this activity. Age-dependent increases in serum Ig levels (> 1 micrograms/ml) were observed in only 2 of 30 NOD/LtSz-scid/scid mice vs 21 of 29 C.B-17/Sz-scid/scid animals. The multiple defects in innate and adaptive immunity unique to the NOD/LtSz-scid/scid mouse provide an excellent in vivo environment for reconstitution with human hematopoietic cells.

Prevalence of Theileria and Babesia species in Tunisian sheep.

PubMed

Rjeibi, Mohamed R; Darghouth, Mohamed A; Gharbi, Mohamed

2016-05-24

In this study, the prevalence of Theileria and Babesia species in sheep was assessed with Giemsastained blood smear examination and polymerase chain reaction to identify the different piroplasms in 270 sheep from three Tunisian bioclimatic zones (north, centre, and south). The overall infection prevalence by Babesia spp. and Theileria spp. in Giemsa-stained blood smears was 2.9% (8/270) and 4.8% (13/270) respectively. The molecular results showed that sheep were more often infected by Theileria ovis than Babesia ovis with an overall prevalence of 16.3% (44/270) and 7.8% (21/270) respectively (p = 0.01). The molecular prevalence by Babesia ovis was significantly higher in females than in males (p < 0.05). According to localities B. ovis was found exclusively in sheep from the centre of Tunisia (Kairouan) whereas Theileria ovis was found in all regions. Infections with T. ovis and B. ovis were confirmed by sequencing. The sequence of T. ovis in this study (accession numbers KM924442) falls into the same clade as T. ovis deposited in GenBank. The T. ovis amplicons (KM924442) showed 99%-100% identities with GenBank sequences. Moreover, comparison of the partial sequences of 18S rRNA gene of B. ovis described in this study (KP670199) revealed 99.4% similarity with B. ovis recently reported in northern Tunisia from sheep and goats. Three nucleotides were different at positions 73 (A/T), 417 (A/T), and 420 (G/T). It also had 99% identity with B. ovis from Spain, Turkey and Iraq. The results suggest a high T. ovis prevalence in Tunisia with a decreasing north-south gradient. This could be correlated to the vector tick distribution.

Pharmaceutical studies of levothyroxine sodium hydrate suppository provided as a hospital preparation.

PubMed

Hamada, Yuhei; Masuda, Kazushi; Okubo, Masato; Nakasa, Hiromitsu; Sekine, Yuko; Ishii, Itsuko

2015-01-01

The levothyroxine sodium hydrate suppository (L-T4-suppository) is provided as a hospital preparation for the treatment of hypothyroid patients with dysphagia in Japan because only oral preparations of levothyroxine sodium (L-T4) are approved for the treatment of hypothyroidism. However, it has been found that serum thyroxine and triiodothyronine levels do not increase as expected with the hospital preparation, requiring a higher dosage of L-T4 in the L-T4-suppository than in the oral preparations. In this study, to determine an effective thyroid gland hormone-replacement therapy for patients with dysphagia, the pharmaceutical properties of the L-T4-suppository were investigated. Suppositories containing 300 µg L-T4 in a base of Witepsol H-15 and Witepsol E-75 (ratio of 1 : 1) were prepared according to Chiba University Hospital's protocol. Content uniformity, stability, and suppository release were tested. The L-T4-suppository had uniform weight and content. The content and release property were stable over 90 d when the L-T4-suppository was stored at 4 °C and protected from light. The release rate of L-T4 increased as pH increased. However, no L-T4 was released below pH 7.2. The release rate of L-T4 decreased as temperature decreased. These findings suggest that the low level of release of L-T4 in the rectum under physiological conditions may be the cause of the low serum thyroxine and triiodothyronine levels following L-T4-suppository administration.

Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats

PubMed Central

2012-01-01

Background Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is induced by LT has been suggested to be a principal mechanism of lung edema and mortality in rodents. Since LT-induced death occurs more rapidly in rats than in mice, suggesting that other mechanisms in addition to the heart dysfunction may be contributed to the fast progression of LT-induced pathogenesis in rats. Coagulopathy may contribute to circulatory failure and lung injury. However, the effect of LT on coagulation-induced lung dysfunction is unclear. Methods To investigate the involvement of coagulopathy in LT-mediated pathogenesis, the mortality, lung histology and coagulant levels of LT-treated rats were examined. The effects of activated protein C (aPC) on LT-mediated pathogenesis were also evaluated. Results Fibrin depositions were detected in the lungs of LT-treated rats, indicating that coagulation was activated. Increased levels of plasma D-dimer and thrombomodulin, and the ameliorative effect of aPC further suggested that the activation of coagulation-fibrinolysis pathways plays a role in LT-mediated pathogenesis in rats. Reduced mortality was associated with decreased plasma levels of D-dimer and thrombomodulin following aPC treatments in rats with LT-mediated pathogenesis. Conclusions These findings suggest that the activation of coagulation in lung tissue contributes to mortality in LT-mediated pathogenesis in rats. In addition, anticoagulant aPC may help to develop a feasible therapeutic strategy. PMID:23170801

Defense Acquisition Research Journal. Volume 22, Number 1, Issue 72.

DTIC Science & Technology

2015-01-01

Capt Allen J. DeNeve, USAF, Lt Col Erin T. Ryan , USAF, Lt Col Jonathan D. Ritschel, USAF, and Christine Schubert Kabban The Effects of System...USAF, Lt Col Erin T. Ryan , USAF, Lt Col Jonathan D. Ritschel, USAF, and Christine Schubert Kabban A regression technique is used to predict cost...practices. Capt Allen J. DeNeve, USAF, Lt Col Erin T. Ryan , USAF, Lt Col Jonathan D. Ritschel, USAF, and Christine Schubert Kabban, in “Taming the

Pharmacokinetics of coadministration of levothyroxine sodium and alendronate sodium new effervescent formulation.

PubMed

Bone, H G; Walter, M A; Hurley, M E; Epstein, S

2017-05-01

No clinically important pharmacokinetic interference of alendronate occurred between a new effervescent formulation of alendronate and levothyroxine when coadministered. The combination does not materially affect levothyroxine absorption. Concurrent treatment of osteoporosis with alendronate (Aln) and hypothyroidism with levothyroxine (LT4) may be problematic because both drugs are to be taken separately after fasting overnight. The primary objective was to assess pharmacokinetic interactions between a new effervescent formulation of Aln (Aln-NEF) and LT4. A randomized, open-label, 3-way crossover study was conducted in 30 healthy adults (15 women). Subjects were dosed 3 times, separated by 35 days, after overnight fasts, with Aln-NEF alone (70 mg), LT4 alone (600 μg), or Aln-NEF and LT4 concurrently. Samples were analyzed for plasma Aln and serum LT4. Pharmacokinetic drug-drug interaction was assessed using 90% confidence intervals (CIs) for the test/reference ratio of the geometric means for area under the concentration-time curve from time zero to last measureable time point (AUC 0-t ) and maximum concentration (C max ). Results were compared to the default no-effect boundaries of 80 to 125% for the ratio Aln-NEF and LT4 concurrently/Aln-NEF alone and the ratio Aln-NEF and LT4 concurrently/LT4 alone. Geometric mean ratios (Aln-NEF with LT4/Aln-NEF alone) were 0.927 (90% CI 0.795-1.081) for AUC 0-8 and 0.912 (90% CI 0.773-1.077) for C max , demonstrating LT4 does not appreciably affect the pharmacokinetics of Aln. Geometric mean ratios (LT4 with Aln-NEF/LT4 alone) were 1.049 (90% CI 0.983-1.119) for AUC 0-48 and 1.075 (90% CI 1.006-1.148) for C max , demonstrating LT4 is bioequivalent between the 2 treatments. Coadministration of Aln-NEF and LT4 was well tolerated. There was no clinically important pharmacokinetic interference between the Aln-NEF formulation and LT4. Aln-NEF does not materially affect LT4 absorption.

Thyroxine Treatment With Softgel Capsule Formulation: Usefulness in Hypothyroid Patients Without Malabsorption.

PubMed

Trimboli, Pierpaolo; Virili, Camilla; Centanni, Marco; Giovanella, Luca

2018-01-01

Levothyroxine sodium (LT4) is the therapy of choice for hypothyroidism. In the last decade, new LT4 formulations, such as liquid and softgel capsules, became available. Even if some evidence has been reached in the efficacy of liquid LT4 in patients with suboptimal TSH on tablet LT4, the usefulness of softgel LT4 has been rarely studied. This study aimed at evaluating the effect of switching from tablet to softgel LT4 patients without increased need for LT4. TSH was used as proxy of LT4 bioavailability and effectiveness. During the period from April to August 2017, 19 patients on tablet LT4 treatment for hypothyroidism, mostly due to autoimmune thyroiditis, were enrolled. Subjects with causes of malabsorption or increased requirement of LT4 were previously excluded. Patients finally included were asked to switch from tablet to softgel LT4 formulation at unchanged dose and ingestion fashion (30 min before breakfast). TSH was measured with chemiluminescence immunoassays. According to exclusion and inclusion criteria, 19 patients were finally selected. One of these had headache 4 days later and come back to tablet LT4, and 18 of them (16W/2M; mean age = 55 years; BMI 22.7 kg/m 2 ) completed the study. They were treated with a median LT4 dose of 88 μg/day and showed a median TSH value of 3.33 mIU/L. The rate of cases with TSH ≤ 4.0 mIU/L was 61.1% (11/18 cases). When patients were re-evaluated after 3 months of softgel LT4, we observed that TSH reached levels under 4.0 mIU/L in 16/18 (88.9%) patients, TSH was lower in 11 cases, and in 6 out of 7 patients with pre-switch TSH values over the normal range. Overall, TSH values on softgel LT4 (median 1.90 mIU/L) was significantly lower from that observed during tablet LT4 ( p  = 0.0039). These data show that hypothyroid patients with no proven malabsorption may have an improved TSH following 3 months from the switch from tablet to softgel LT4 preparation at unchanged dose.

Evaluation of Dynamic Changes in Rating of Russian Information Sources of Medical Education Sites.

PubMed

Vasilyeva, Irina V; Arseniev, Sergey B

2016-01-01

The aim of the present study is to analyze dynamic changes in the rating of information sources of medical literature in the sites of the following electronic libraries (<rsl.ru>, <rssi.ru>, <elibrary.ru>) and the rating of information sources for electronic medical books (<booksmed.com>, <medliter.ru> <medbook.net.ru>). While using the on-line programs Alexa and Cy-pr, we have analyzed their website's rating and identified basic data and time-varying site data obtained for fourteen months. Alexa Rank rating was calculated for each sitemonthly. Our study has shown that the most popular information sources of medical education among the six studied sites for Russian users is <elibrary.ru>; the site <rssi.ru> is at the second place.

Examining Regionalization Efforts to Develop Lessons Learned and Consideration for Department of Defense Medical Facilities

DTIC Science & Technology

2017-03-23

Consideration for Department of Defense Medical Facilities Erik B. Schuh Follow this and additional works at: https://scholar.afit.edu/etd Part of the...Citation Schuh, Erik B., "Examining Regionalization Efforts to Develop Lessons Learned and Consideration for Department of Defense Medical Facilities...Consideration for Department of Defense Medical Facilities THESIS Erik B. Schuh, 2Lt, USAF AFIT-ENS-MS-17-M-156 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR

Chronic Inhalation Toxicity of Unsymmetrical Dimethylhydrazine: Oncogenic Effects

DTIC Science & Technology

1984-10-01

maintained for various time periods postexposure as long as: hamsters, 17 months; mice and rats, 19 months; and dogs , 54 months. The lung was a target organ...Force Base, Ohio R. H. Bruner, Lt Col United States Army BLOCK 18. Subject Terms Peroral Dogs Rats Neoplastic Mice Non-Neoplastic Hamsters BLOCK 19...Abstract An indication of hepatotoxicity in dogs was revealed by transitory elevation in SGPT and BSP values for dogs exposed to 5 ppm. Since the UDMH

Genghis Khan: Leadership for the Airland Battle

DTIC Science & Technology

1988-04-01

COLLEGE AIR UNIVERSITY MAXWELL AFB, AL 36112-5542 t , , _ I _ * LIAUIVmzKz // /9) REPOR SOCUMUNTATION PAGEON it. WPM UIQPM fP",, A101-, W ., Ia itT zN... succesful completion, The advsor Lt Cot Rodger L, Tunnel, Army Instructor Group, Air Command an~d Staff College, provided invaluable advice in all...Command and Staff College at Maxwell Air Force Base, Alabama, where he resides with Beata and their two children, Melissa and Justin. ,Aooession Fror

Air Force Logistics Command DCS/Materiel Management 1988-9 Master Plan

DTIC Science & Technology

1988-10-01

MMMAI, AUTOVON 787-2587 Member: Mr James Gibbs, HQ AFLC/MMMES, AUTOVON 787-3407 PROJECT SPONSOR: Mr Steve Stewart, HQ AFLC/MMME, AUTOVON 787-5280 HQ...AFLC OPR: Mr James Gibbs, HQ AFLC/MMMES, AUTOVON 787-3407 PROBLEM STATEMENT: Item managers do not have a procedure to analyze the economic costs and/or...513) 429-0055 Contractor: The Analytic Sciences Corporation (Contact) Mr Rich Mabe , (513) 426-1040 PROJECT SPONSOR: Lt Col Michael Williams, HQ USAF

Validation of the Air Force Weather Agency Ensemble Prediction Systems

DTIC Science & Technology

2014-03-27

by Mr. Evan L. Kuchera. Also, I would like to express my gratitude to Mr. Jeff H. Zaunter for painstakingly working with me to provided station...my fellow AFIT classmates, Capt Jeremy J. Hromsco, Capt Haley A. Homan, Capt Kyle R. Thurmond and 2Lt Coy C. Fischer for their support and...Codes. The raw METARs and SPECIs were decoded and provided for this research by Mr. Jeff Zautner, 14/WS Meteorologist, Tailored Product Analyst

Installation Restoration Program. Phase 2. Confirmation Quantification. Stage 2 for MacDill Air Force Base, Florida. Volume 2

DTIC Science & Technology

1988-07-22

Inc. of Savannah, Georgia and Tallahassee, Florida provided analytical services. Michael Newberry, Captain USAF, and Jeff Mason, 2d LT., USAF, from...2803-19 AG AP6 ST;- ES Ci eit 2803-20 A? APC S -2 ES 23033-23 AG .AF6 SD-S 2803-22 AC AP6 SD-4 E.> PARAMIETER 280u- .y 2&u r 23-2: 2803-22 Bezo (g.h.1

Standardized Measures of Merit (MOM) Dictionary.

DTIC Science & Technology

1979-03-20

BLIP) of the target. 3. Coordinate transformations and rotation routines are required to compare the differences between the reference track and...AD-AI24 070 STANDARDIZED MEASURES OF MERIT (MOM) OICTIONARY(U) AI R I/lt FORCE ELECTRONIC WARFARE C ENTE R K ELLY AFR TX 20 MAR 79 UNCLASSIFEF/G5/2 5...SECURITY CLASSIFIIATIONd Of THIS5 PAGE READ Data Entered) REPORT DOCUMENTATION PAGE BEFORE COMPLETING FORM REPOR NUME.R ~GOVT ACCESSION NO. 3. RECIPIENT’S

Healing The Operational Environment: Encouraging Mental Health Help-Seeking Behavior

DTIC Science & Technology

2016-02-10

of the four pillars of wellness.24 By design the IRST sessions focus on the delivery of information using a small group model of not more than 10...Brown, Lt Col, United States Air Force A Research Report Submitted to the Faculty In Partial Fulfillment of the Graduation Requirements Advisor...DISCLAIMER The views expressed in this academic research paper are those of the author and do not reflect the official policy or position of the US

Modifying the Weinberger-Powell Doctrine for the Modern Geo-Strategic Environment

DTIC Science & Technology

2017-03-31

Geo-Strategic Environment 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Scott T. Yeatman, Lt Col, USAF 5d...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER 9... environment , its prescriptive nature, and its misunderstanding of the modern utility of force. This paper examines each of these issues then proposes

Environmental Assessment for Wing Infrastructure Development Outlook (WINDO) Plan Shaw Air Force Base, South Carolina

DTIC Science & Technology

2004-10-01

officially established on August 30, 1941 and was named after 1st Lt. Ervin D. Shaw, a Sumter County resident who was killed in action during World War I...Examples of the animal species likely to occur within this community include the cottontail, mockingbird , American robin, and crow. At the Poinsett...include the white-tailed deer, red fox, raccoon, opossum, striped skunk, cottontail, meadowlark, mockingbird , American kestrel, fence lizard, and

Force Identification from Structural Response

DTIC Science & Technology

1999-12-01

STUDENT AT (If applicable) AFIT/CIA Univ of New Mexico A 6c. ADDRESS (City, State, and ZIP Code ) 7b. ADDRESS (City, State, and ZIP Code ) Wright...ADDRESS (City, State, and ZIP Code ) 10. SOURCE OF FUNDING NUMBERS PROGRAM PROJECT TASK WORK UNIT ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE (h,,clude...FOR PUBLIC RELEASE IAW AFR 190-1 ERNEST A. HAYGOOD, 1st Lt, USAF Executive Officer, Civilian Institution Programs 17. COSATI CODES 18. SUBJECT TERMS

HaLT2- an enhanced lumber grading trainer

Treesearch

Powsiri Klinkhachorn; Charles Gatchell; Charles McMillin; Ravi Kothari; Dennis Yost

1992-01-01

This paper reports on HaLT2, an improved version of HaLT (Hardwood Lumber Traning Program)- a computer program that provides training in lumber grading. The newly added enhancements In HaLT2 will provide training for both novice and experienced hardwood lumber graders in accordance with National Hardwood Lumber Assodation (NHLA) rules. HaLT2 is more accurate, easier to...

Pharmacokinetics of total thyroxine in dogs after administration of an oral solution of levothyroxine sodium.

PubMed

Le Traon, G; Burgaud, S; Horspool, L J I

2008-04-01

Oral L-thyroxine (L-T4) supplementation is used to replace thyroid hormone concentrations in dogs with hypothyroidism. The pharmacokinetics of L-T4 following administration of a solution (Leventa) was investigated in healthy dogs. L-T4 was absorbed fairly rapidly (t(max) 3 h). A mean bioavailability of 22% was calculated following a single oral administration of 40 microg L-T4/kg body weight. Repeated oral administration at the same dose for 14 consecutive days did not lead to any accumulation of T4 in serum. After intravenous administration of L-T4, a serum half-life of 11.6 h was calculated. Food intake concomitant with L-T4 oral administration delayed L-T4 absorption and decreased its rate and extent by about 45%. The relative bioavailability of L-T4 following administration of a tablet formulation was about 50% of that of the L-T4 solution. The pharmacokinetic properties of liquid L-T4 after oral administration support the use of a dose rate of 20 microg/kg once daily, as a starting dose for replacement therapy in dogs with hypothyroidism.

KSC-99pp1066

NASA Image and Video Library

1999-08-24

At Cape Canaveral Air Station's (CCAS) Complex 3/4, officials held a ceremony kicking off a year-long series of events commemorating 50 years of launches from the Space Coast that began with the Bumper rockets. At left is artist Darlene Egli who designed the 50th anniversary logo next to her. On stage, from left to right, are Lt. Col. Randall K. Horn, Commander, CCAS; Brig. Gen. Donald P. Pettit, Commander, 45th Space Wing; Congressman David Weldon, 15th Congressional District of the State of Florida; Lieutenant Governor of the State of Florida Frank T. Brogan; Center Director Roy D. Bridges; and Executive Director Edward F. Gormel, Joint Performance Management Office. After six Bumper launches at White Sands Proving Grounds, N.M., and a failed Bumper 7, a successful Bumper 8 lifted off July 24, 1950, from Complex 3/4 to conduct aerodynamic investigations around Mach 7 at relatively low altitudes. The kick-off event also inaugurated a student art contest to design a commemorative etching. The winning artwork will be permanently displayed on a 24-inch black granite square in the U.S. Space Walk Hall of Fame in Titusville, Fla

A functional antigen in a practical crop: LT-B producing maize protects mice against Escherichia coli heat labile enterotoxin (LT) and cholera toxin (CT).

PubMed

Chikwamba, Rachel; Cunnick, Joan; Hathaway, Diane; McMurray, Jennifer; Mason, Hugh; Wang, Kan

2002-10-01

We have produced a functional heat labile enterotoxin (LT-) B subunit of Escherichia coli in maize. LT-B is a multimeric protein that presents an ideal model for an edible vaccine, displaying stability in the gut and inducing mucosal and systemic immune responses. Transgenic maize was engineered to synthesize the LT-B polypeptides, which assembled into oligomeric structures with affinity for G(M1) gangliosides. We orally immunized BALB/c mice by feeding transgenic maize meal expressing LT-B or non-transgenic maize meal spiked with bacterial LT-B. Both treatments stimulated elevated IgA and IgG antibodies against LT-B and the closely related cholera toxin B subunit (CT-B) in serum, and elevated IgA in fecal pellets. The transgenic maize induced a higher anti-LT-B and anti-CT-B mucosal and serum IgA response compared to the equivalent amount of bacterial LT-B spiked into maize. Following challenge by oral administration of the diarrhea inducing toxins LT and CT, transgenic maize-fed mice displayed reduced fluid accumulation in the gut compared to non-immunized mice. Moreover, the gut to carcass ratio of immunized mice was not significantly different from the PBS (non-toxin) challenged control group. We concluded that maize-synthesized LT-B had features of the native bacterial LT-B such as molecular weight, G(M1) binding ability, and induction of serum and mucosal immunity. We have demonstrated that maize, a major food and feed ingredient, can be efficiently transformed to produce, accumulate, and store a fully assembled and functional candidate vaccine antigen.

Low Triiodothyronine Syndrome in Patients With Radiation Enteritis

PubMed Central

Fan, Shengxian; Ni, Xiaodong; Wang, Jian; Zhang, Yongliang; Tao, Shen; Chen, Mimi; Li, Yousheng; Li, Jieshou

2016-01-01

Abstract The implications of low triiodothyronine syndrome (LT3S) in patients with radiation enteritis (RE) have not been properly investigated. As such, we conducted this cohort study to investigate the association between LT3S and RE, to explore the etiology of LT3S in RE, to evaluate the clinical features and clinical outcomes of LT3S patients, and to inspect the correlation of clinical variables and LT3S in RE. This prospective study included 39 RE patients. Medical records and various laboratory parameters (including thyroidal, tumorous, nutritional, and radiotherapy variables) were collected in all participants. Our results showed that the incidence of LT3S was 84.6% in patients with RE. Total protein (71.7 ± 5.7 vs 63.2 ± 9.6 g/L, P = 0.04) and albumin (ALB, 46.0 ± 4.6 vs 38.7 ± 5.3 g/L, P = 0.01) were significantly lower in LT3S group compared with those in euthyroid group. Standard thyroid-stimulating hormone index (−0.89 ± 2.11 vs −2.39 ± 1.33, P = 0.03) and sum activity of deiodinases (19.74 ± 4.19 vs 12.55 ± 4.32 nmol/L, P = 0.01) were significantly lower in LT3S group. Patients with LT3S suffered longer duration of hospitalization (48.25 ± 23.29 days in LT3S vs 26.75 ± 10.56 days in euthyroid, P = 0.036). Low serum ALB (β = 0.694, 95% CI = 0.007–0.190, P = 0.037) was the only significant predictor of LT3S. LT3S was common in RE patients. A hypodeiodination condition and a potential pituitary-thyrotroph dysfunction might play a role in the pathophysiology of LT3S in RE. Worse nutritional status and clinical outcomes were confirmed in RE patients with LT3S. Furthermore, total protein and ALB were observed as protective and differentiating parameters of LT3S in RE. In summary, this was the 1st investigation to evaluate the clinical correlation between RE and LT3S, investigate the prevalence of LT3S in RE, and explore the pathogenesis of LT3S, despite the limitation of a relatively small sample size. These results will hopefully encourage future research to place greater emphasis on early identification of LT3S in RE patients. PMID:26871787

Low Triiodothyronine Syndrome in Patients With Radiation Enteritis: Risk Factors and Clinical Outcomes an Observational Study.

PubMed

Fan, Shengxian; Ni, Xiaodong; Wang, Jian; Zhang, Yongliang; Tao, Shen; Chen, Mimi; Li, Yousheng; Li, Jieshou

2016-02-01

The implications of low triiodothyronine syndrome (LT3S) in patients with radiation enteritis (RE) have not been properly investigated. As such, we conducted this cohort study to investigate the association between LT3S and RE, to explore the etiology of LT3S in RE, to evaluate the clinical features and clinical outcomes of LT3S patients, and to inspect the correlation of clinical variables and LT3S in RE.This prospective study included 39 RE patients. Medical records and various laboratory parameters (including thyroidal, tumorous, nutritional, and radiotherapy variables) were collected in all participants.Our results showed that the incidence of LT3S was 84.6% in patients with RE. Total protein (71.7 ± 5.7 vs 63.2 ± 9.6 g/L, P = 0.04) and albumin (ALB, 46.0 ± 4.6 vs 38.7 ± 5.3 g/L, P = 0.01) were significantly lower in LT3S group compared with those in euthyroid group. Standard thyroid-stimulating hormone index (-0.89 ± 2.11 vs -2.39 ± 1.33, P = 0.03) and sum activity of deiodinases (19.74 ± 4.19 vs 12.55 ± 4.32 nmol/L, P = 0.01) were significantly lower in LT3S group. Patients with LT3S suffered longer duration of hospitalization (48.25 ± 23.29 days in LT3S vs 26.75 ± 10.56 days in euthyroid, P = 0.036). Low serum ALB (β = 0.694, 95% CI = 0.007-0.190, P = 0.037) was the only significant predictor of LT3S.LT3S was common in RE patients. A hypodeiodination condition and a potential pituitary-thyrotroph dysfunction might play a role in the pathophysiology of LT3S in RE. Worse nutritional status and clinical outcomes were confirmed in RE patients with LT3S. Furthermore, total protein and ALB were observed as protective and differentiating parameters of LT3S in RE. In summary, this was the 1st investigation to evaluate the clinical correlation between RE and LT3S, investigate the prevalence of LT3S in RE, and explore the pathogenesis of LT3S, despite the limitation of a relatively small sample size. These results will hopefully encourage future research to place greater emphasis on early identification of LT3S in RE patients.

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind, Crossover Trial of Liothyronine Versus Levothyroxine

PubMed Central

Zemskova, Marina; Linderman, Joyce D.; Smith, Sheila; Drinkard, Bart; Sachdev, Vandana; Skarulis, Monica C.; Kozlosky, Merel; Csako, Gyorgy; Costello, Rene; Pucino, Frank

2011-01-01

Context: Levothyroxine (l-T4) therapy is based on the assumption that the conversion of T4 into T3 provides adequate amounts of active hormone at target tissues. However, in rodents, l-T4 alone does not restore a euthyroid state in all tissues. Previous combination l-T4/liothyronine (l-T3) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action. Objective: Our objective was to evaluate the efficacy of thyroid hormone replacement with l-T4 or l-T3 at doses producing equivalent normalization of TSH. Participants, Design, and Setting: Fourteen hypothyroid patients participated in this randomized, double-blind, crossover intervention at the National Institutes of Health Clinical Center. Interventions: l-T3 or l-T4 were administered thrice daily to achieve a target TSH from 0.5–1.5 mU/liter. Volunteers were studied as inpatients after 6 wk on a stable dose and at the target TSH. Main Outcome Measures: Serum thyroid hormones, lipid parameters, and indices of glucose metabolism were evaluated. Results: No difference was observed in TSH between l-T3 and l-T4 treatments. l-T3 resulted in significant weight loss [l-T4, 70.6 ± 12.5, vs. l-T3, 68.5 ± 11.9 kg (P = 0.009)] and in a 10.9 ± 10.0% decrease in total cholesterol (P = 0.002), 13.3 ± 12.1% decrease in low-density lipoprotein-cholesterol (P = 0.002), and an 18.3 ± 28.6% decrease in apolipoprotein B (P = 0.018). No significant differences were observed in high-density lipoprotein-cholesterol, heart rate, blood pressure, exercise tolerance, or insulin sensitivity. Conclusions: The substitution of l-T3 for l-T4 at equivalent doses (relative to the pituitary) reduced body weight and resulted in greater thyroid hormone action on the lipid metabolism, without detected differences in cardiovascular function or insulin sensitivity. PMID:21865366

ITALIAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS STATEMENT-REPLACEMENT THERAPY FOR PRIMARY HYPOTHYROIDISM: A BRIEF GUIDE FOR CLINICAL PRACTICE.

PubMed

Guglielmi, Rinaldo; Frasoldati, Andrea; Zini, Michele; Grimaldi, Franco; Gharib, Hossein; Garber, Jeffrey R; Papini, Enrico

2016-11-01

Hypothyroidism requires life-long thyroid hormone replacement therapy in most patients. Oral levothyroxine (LT4) is an established safe and effective treatment for hypothyroidism, but some issues remain unsettled. The Italian Association of Clinical Endocrinologists appointed a panel of experts to provide an updated statement for appropriate use of thyroid hormone formulations for hypothyroidism replacement therapy. The American Association of Clinical Endocrinologists' protocol for standardized production of clinical practice guidelines was followed. LT4 is the first choice in replacement therapy. Thyroid-stimulating hormone (TSH) should be maintained between 1.0 and 3.0 mIU/L in young subjects and at the upper normal limit in elderly or fragile patients. Achievement of biochemical targets, patient well-being, and adherence to treatment should be addressed. In patients with unstable serum TSH, a search for interfering factors and patient compliance is warranted. Liquid or gel formulations may be considered in subjects with hampered LT4 absorption or who do not allow sufficient time before or after meals and LT4 replacement. Replacement therapy with LT4 and L-triiodothyronine (LT3) combination is generally not recommended. A trial may be considered in patients with normal values of serum TSH who continue to complain of symptoms of hypothyroidism only after co-existent nonthyroid problems have been excluded or optimally managed. LT3 should be administered in small (LT4:LT3 ratio, 10:1 to 20:1) divided daily doses. Combined therapy should be avoided in elderly patients or those with cardiac risk factors and in pregnancy. LT4 therapy should be aimed at resolution of symptoms of hypothyroidism, normalization of serum TSH, and improvement of quality of life. In selected cases, the use of liquid LT4 formulations or combined LT4/LT3 treatment may be considered to improve adherence to treatment or patient well-being. AACE = American Association of Clinical Endocrinologists FT3 = free triiodothyronine FT4 = free thyroxine LT3 = levotriiodothyronine LT4 = levothyroxine MeSH = medicine medical subject headings QoL = quality of life TSH = thyroid-stimulating hormone.

Lymphotoxin beta receptor (Lt betaR): dual roles in demyelination and remyelination and successful therapeutic intervention using Lt betaR-Ig protein.

PubMed

Plant, Sheila R; Iocca, Heather A; Wang, Ying; Thrash, J Cameron; O'Connor, Brian P; Arnett, Heather A; Fu, Yang-Xin; Carson, Monica J; Ting, Jenny P-Y

2007-07-11

Inflammation mediated by macrophages is increasingly found to play a central role in diseases and disorders that affect a myriad of organs, prominent among these are diseases of the CNS. The neurotoxicant-induced, cuprizone model of demyelination is ideally suited for the analysis of inflammatory events. Demyelination on exposure to cuprizone is accompanied by predictable microglial activation and astrogliosis, and, after cuprizone withdrawal, this activation reproducibly diminishes during remyelination. This study demonstrates enhanced expression of lymphotoxin beta receptor (Lt betaR) during the demyelination phase of this model, and Lt betaR is found in areas enriched with microglial and astroglial cells. Deletion of the Lt betaR gene (Lt betaR-/-) resulted in a significant delay in demyelination but also a slight delay in remyelination. Inhibition of Lt betaR signaling by an Lt betaR-Ig fusion decoy protein successfully delayed demyelination in wild-type mice. Unexpectedly, this Lt betaR-Ig decoy protein dramatically accelerated the rate of remyelination, even after the maximal pathological disease state had been reached. This strongly indicates the beneficial role of Lt betaR-Ig in the delay of demyelination and the acceleration of remyelination. The discrepancy between remyelination rates in these systems could be attributed to developmental abnormalities in the immune systems of Lt betaR-/- mice. These findings bode well for the use of an inhibitory Lt betaR-Ig as a candidate biological therapy in demyelinating disorders, because it is beneficial during both demyelination and remyelination.

The dynamic and clinical significance of autoantibodies and immunoglobulins in liver transplant recipients.

PubMed

Stanca, Carmen M; Aloman, Costica; Fiel, Maria Isabel; Raja, Kaiser; Uskudar, Oguz; Florman, Sander; Schiano, Thomas D

2016-03-01

Little is known about autoantibody pattern in liver transplantation (LT). The aim of the study was to examine autoantibodies (AAB) and immunoglobulins in patients with end-stage liver disease before and after LT. Patients with LT who underwent post-LT biopsies between 10/2008 and 8/2011 were enrolled. AAB were assessed at the time of LT and liver biopsy. Demographics, serum immunoglobulins, AAB, and liver histology (explant, post-LT biopsies) were analyzed. Two hundred and twenty patients (M/F 143/77; age at LT 54 (19-73)) were included; AAB and immunoglobulins were evaluated in 76 patients. Length of follow-up from LT was 285 (30-1462) days. Sixty-one percent of patients had hepatitis C (HCV); 83% developed recurrent HCV. A significant decrease in IgG, IgA, IgM (p < 0.001 each), anticardiolipin antibodies IgG and IgM (p = 0.02), and beta-2 microglobulin (p = 0.004) was observed post-LT. HCV patients had higher IgG (p = 0.005), rheumatoid factor (p = 0.044) before LT; elevated IgM was associated with increased inflammation in the explant (p = 0.007). Lower IgG levels and antismooth muscle antibodies were present before LT in a higher percentage in patients who would develop recurrent HCV (p = 0.004, p = 0.077, respectively). In conclusion, AAB change significantly after LT and have a different pattern in HCV. Some immunological markers are associated with HCV recurrence and advanced inflammation on explant. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Gen. Joseph F. Dunford, Jr. > Joint Chiefs of Staff > Article View

Science.gov Websites

Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management Chiefs of Staff, the nation's highest-ranking military officer, and the principal military advisor to the

DefenseLink Special: World War I - The Great War Remembered

Science.gov Websites

Us The War That Didn't End All Wars By Jim Garamone American Forces Press Service They called it , and the U.S. Congress declared war. The first American troops journeyed to France in June 1917 phrase that gave heart to the Allies. Army Gen. John J. Pershing commanded the American Expeditionary

Planning for Action: Campaign Concepts and Tools

DTIC Science & Technology

2012-08-01

142 10-15. Stability Mechanisms – Army .................................... 143 10-16. Stability Mechanisms – Joint...defeat mechanisms, which focus 143 the destructive and coercive capabilities of the force to provide security and public order and safety for...Matthew B. Ridgway. GEN Ridgway successfully led the 82d Airborne Division and XVIII Airborne Corps in the ETO during World War II and Eighth (US

Effects-Based Operations: Useful or Useless

DTIC Science & Technology

2010-05-03

the effects -based approach largely irrelevant. 30 The idea of Consequence Identification, however, is not to identify all outcomes , but rather to... effects -based thinking could provide operational planners and commanders with a valuable consequence identification tool. It further argues that System...to achieve specific effects that contribute directly to desired military and political outcomes .” 14 Air Force Brig Gen David Deptula further writes

Hashimoto's Thyroiditis Pathology and Risk for Thyroid Cancer

PubMed Central

Paparodis, Rodis; Imam, Shahnawaz; Todorova-Koteva, Kristina; Staii, Anca

2014-01-01

Background: Hashimoto's thyroiditis (HT) has been found to coexist with differentiated thyroid cancer (DTC) in surgical specimens, but an association between the two conditions has been discounted by the medical literature. Therefore, we performed this study to determine any potential relationship between HT and the risk of developing DTC. Methods: We collected data for thyrotropin (TSH), thyroxine (T4), thyroid peroxidase antibody (TPO-Ab) titers, surgical pathology, and weight-based levothyroxine (LT4) replacement dose for patients who were referred for thyroid surgery. Patients with HT at final pathology were studied further. To estimate thyroid function, patients with preoperative hypothyroid HT (Hypo-HT) were divided into three equal groups based on their LT4 replacement: LT4-Low (<0.90 μg/kg), LT4-Mid (0.90–1.43 μg/kg), and LT4-High (>1.43 μg/kg). A group of preoperatively euthyroid (Euth-HT) patients but with HT by pathology was also studied. All subjects were also grouped based on their TPO-Ab titer in TPO-high (titer >1:1000) or TPO-low/negative (titer <1:1000 or undetectable) groups. The relationship of HT and DTC was studied extensively. Results: Of 2811 subjects, 582 had HT on surgical pathology, 365 of whom were Euth-HT preoperatively. DTC was present in 47.9% of the Euth-HT, in 59.7% of LT4-Low, 29.8% of LT4-Mid, and 27.9% of LT4-High groups. The relative risk (RR) for DTC was significantly elevated for the Euth-HT and LT4-Low groups (p<0.001), but not for the LT4-Mid or LT4-High replacement dose groups. TPO-low/negative status conferred an increased RR in the Euth-HT and LT4-Low replacement dose groups (p<0.001 both), while TPO-high status decreased it in Euth-HT group (p<0.05) and made it nonsignificant in the LT4-Low group. Conclusions: HT pathology increases the risk for DTC only in euthyroid subjects and those with partially functional thyroid glands (LT4-Low) but not in fully hypothyroid HT (LT4-Mid and LT4-High). High TPO-Ab titers appear to protect against DTC in patients with HT. PMID:24708347

The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the ¹³C-ketoisocaproate breath test.

PubMed

Afolabi, Paul R; Scorletti, Eleonora; Smith, Debbie E; Almehmadi, Amal A; Calder, Philip C; Byrne, Christopher D

2018-06-26

Hepatic mitochondrial function (HMF) assessed by the ¹³C-ketoisocaproate breath test (¹³C-KICA BT) has been previously shown to be significantly associated with the severity of biopsy proven non-alcoholic fatty liver disease (NAFLD). However, it is uncertain whether any perturbation in HMF relates specifically to severity of liver disease or factors associated with metabolic syndrome within non-alcoholic fatty liver disease (NAFLD). Our aim was to investigate whether there was any change in HMF assessed by ¹³C-KICA BT in patients with NAFLD compared to control subjects, and to assess the factors that are independently associated with HMF. 77 patients with NAFLD and 11 healthy control subjects were studied. HMF was assessed using ¹³C-KICA BT and expressed as cumulative % ¹³C-dose recovered on breath over 1hr (cPDR over 1hr). Liver fat and fibrosis was assessed by transient elastography. Multi-variable linear regression modelling was undertaken to test the independence of associations with HMF. HMF (cPDR over 1hr) was lower in NAFLD compared to controls [13.4% (4.8) v. 21.0% (6.3); p< 0.0001)]. In NAFLD, HMF was lower in patients with diabetes versus no diabetes [12.7% (3.4) v. 14.3% (6.1); p=0.003)]. Regression modelling showed age (β= -0.08; p=0.01), waist circumference (β= -0.08; p=0.01), hip circumference (β= -0.04; p=0.01), aspartate aminotransferase (AST) (β= -0.05; p=0.01) and diabetes status (β= -1.81; p=0.01) were independently associated with HMF (R²= 41.5%; p<0.0001). In patients with NAFLD (compared to healthy subjects), there was a reduction in HMF assessed by the ¹³C-KICA BT. Furthermore, in patients with NAFLD, HMF is independent and inversely associated with age, waist and hip circumference, AST and diabetes status. © 2018 IOP Publishing Ltd.

Inferences on hydrogen bond networks in water from isopermitive frequency investigations.

PubMed

Geethu, P M; Ranganathan, Venketesh T; Satapathy, Dillip K Kumar

2018-06-26

Intermolecular hydrogen bonds play a crucial role in determining the unique characteristics of liquid water. We present low-frequency (1 Hz - 40 MHz) dielectric spectroscopic investigations on water in the presence and absence of added solutes at different temperatures from 10°C to 60°C. The intersection points of temperature dependent permittivity contours at the vicinity of isopermitive frequency (IPF) in water are recorded and its properties are presumed to be related to the extent of hydrogen bond networks in water. IPF is defined as the frequency at which the relative permittivity of water is almost independent of temperature. The set of intersection points of temperature dependent permittivity contours at the vicinity of IPF are characterized by the mean (M_IPF) and root-mean-square deviation/standard deviation (σ_IPF ) associated with IPF. The tunability of M_IPF by the addition of NaCl salt emphasizes the strong correlation between the concentration of ions in water and the M_IPF . The σ_IPF is surmised to be related to the orientational correlations of water dipoles as well as to the intermolecular hydrogen bond networks in water. Further, alterations in σ_IPF is observed with the addition of kosmotropic and chaotropic solutes into water and are thought to arise due to the restructuring of hydrogen bond networks in water in presence of added solutes. Notably, the solute induced reconfiguration of hydrogen bond networks in water or often-discussed structure making/breaking effects of the added solutes in water can be inferred, albeit qualitatively, by examining the M_IPF and σ_IPF. Further, the Gaussian deconvoluted OH-stretching modes present in the Raman Spectra of water and aqueous solutions of IPA and DMF strongly endorses the structural rearrangements occurring in water in presence of kosmotropes and chaotropes and are in-line with the results derived from the root-mean-square deviation in IPF. . © 2018 IOP Publishing Ltd.

Vitamin D status of human immunodeficiency virus-positive patients with advanced liver disease enrolled in the solid organ transplantation in HIV: multi-site study.

PubMed

Branch, Andrea D; Barin, Burc; Rahman, Adeeb; Stock, Peter; Schiano, Thomas D

2014-02-01

An optimal vitamin D status may benefit liver transplantation (LT) patients. Higher levels of 25-hydroxyvitamin D [25(OH)D] mitigate steroid-induced bone loss after LT, correlate with better hepatitis C virus treatment responses, and increase graft survival. This study investigated 25(OH)D levels and assessed strategies for vitamin D deficiency prevention in human immunodeficiency virus (HIV)-positive patients with advanced liver disease who were enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study. 25(OH)D was measured in banked specimens from 154 LT candidates/recipients with the DiaSorin assay; deficiency was defined as a 25(OH)D level < 20 ng/mL. Information about vitamin D supplement use after LT was obtained from medication logs and via surveys. Logistic regression, Cox regression, and linear repeated measures analyses were performed with SAS software. We found that none of the 17 academic medical centers in the United States routinely recommended vitamin D supplements before LT, and only a minority (4/17) recommended vitamin D supplements to all patients after LT. Seventy-one percent of the 139 patients with pre-LT values had vitamin D deficiency, which was significantly associated with cirrhosis (P = 0.01) but no other variable. The vitamin D status improved modestly after LT; however, the status was deficient for 40% of the patients 1 year after LT. In a multivariate linear repeated measures model, a higher pre-LT 25(OH)D level (P < 0.001), specimen collection in the summer (P < 0.001), a routine vitamin D supplementation strategy after LT (P < 0.001), and the time elapsing since LT (P = 0.01) were significantly associated with increases in the post-LT 25(OH)D level; black race was associated with a decreased level (P = 0.02). In conclusion, the majority of patients awaiting LT were vitamin D deficient, and approximately half were vitamin D deficient after LT. More extensive use of vitamin D supplements, more sun exposure, or both are needed to prevent this deficiency in HIV-positive LT candidates and recipients. © 2013 American Association for the Study of Liver Diseases.

The administration of L-thyroxine as soft gel capsule or liquid solution.

PubMed

Vita, Roberto; Fallahi, Poupak; Antonelli, Alessandro; Benvenga, Salvatore

2014-07-01

Levothyroxine (l-T4) is the mainstay of treating hypothyroidism. The tablet is the traditional formulation of l-T4. Tablet l-T4 malabsorption results from either hindered gastric dissolution of the tablet or binding of l-T4 by sequestrants in the intestinal lumen. This review provides an overview of the pharmacokinetics of l-T4 formulations available in the market: the tablet, the soft gel capsule and the oral solution. We review literature on the new formulations and anticipate the areas of future research. Failure of l-T4 treatment to reach target serum thyroid-stimulating hormone levels generally prompts the physicians to increase l-T4 daily dose. In vitro studies have shown that the soft gel capsule releases the active ingredient more consistently at varying pH than the tablet. In addition, in vivo studies have confirmed the in vitro data and have demonstrated that both the soft gel capsule and the liquid formulation are capable to solve tablet l-T4 malabsorption caused by certain drugs, bariatric surgery or coffee. These new formulations may be attractive also for patients who cannot/do not want to change their (improper) habits of l-T4 ingestion. Finally, the oral solution l-T4 could be suitable for patients who cannot swallow the solid formulations.

Rotavirus 2/6 Viruslike Particles Administered Intranasally with Cholera Toxin, Escherichia coli Heat-Labile Toxin (LT), and LT-R192G Induce Protection from Rotavirus Challenge

PubMed Central

O’Neal, Christine M.; Clements, John D.; Estes, Mary K.; Conner, Margaret E.

1998-01-01

We have shown that rotavirus 2/6 viruslike particles composed of proteins VP2 and VP6 (2/6-VLPs) administered to mice intranasally with cholera toxin (CT) induced protection from rotavirus challenge, as measured by virus shedding. Since it is unclear if CT will be approved for human use, we evaluated the adjuvanticity of Escherichia coli heat-labile toxin (LT) and LT-R192G. Mice were inoculated intranasally with 10 μg of 2/6-VLPs combined with CT, LT, or LT-R192G. All three adjuvants induced equivalent geometric mean titers of rotavirus-specific serum antibody and intestinal immunoglobulin G (IgG). Mice inoculated with 2/6-VLPs with LT produced significantly higher titers of intestinal IgA than mice given CT as the adjuvant. All mice inoculated with 2/6-VLPs mixed with LT and LT-R192G were totally protected (100%) from rotavirus challenge, while mice inoculated with 2/6-VLPs mixed with CT showed a mean 91% protection from challenge. The availability of a safe, effective mucosal adjuvant such as LT-R192G will increase the practicality of administering recombinant vaccines mucosally. PMID:9525668

Treatment of patients waitlisted for liver transplant with all-oral direct-acting antivirals is a cost-effective treatment strategy in the United States.

PubMed

Ahmed, Aijaz; Gonzalez, Stevan A; Cholankeril, George; Perumpail, Ryan B; McGinnis, Justin; Saab, Sammy; Beckerman, Rachel; Younossi, Zobair M

2017-07-01

All-oral direct acting antivirals (DAAs) have been shown to have high safety and efficacy in treating patients with hepatitis C virus (HCV) awaiting liver transplant (LT). However, there is limited empirical evidence comparing the health and economic outcomes associated with treating patients pre-LT versus post-LT. The objective of this study was to analyze the cost-effectiveness of pre-LT versus post-LT treatment with an all-oral DAA regimen among HCV patients with hepatocellular carcinoma (HCC) or decompensated cirrhosis (DCC). We constructed decision-analytic Markov models of the natural disease progression of HCV in HCC patients and DCC patients waitlisted for LT. The model followed hypothetical cohorts of 1,000 patients with a mean age of 50 over a 30-year time horizon from a third-party US payer perspective and estimated their health and cost outcomes based on pre-LT versus post-LT treatment with an all-oral DAA regimen. Transition probabilities and utilities were based on the literature and hepatologist consensus. Sustained virological response rates were sourced from ASTRAL-4, SOLAR-1, and SOLAR-2. Costs were sourced from RedBook, Medicare fee schedules, and published literature. In the HCC analysis, the pre-LT treatment strategy resulted in 11.48 per-patient quality-adjusted life years and $365,948 per patient lifetime costs versus 10.39 and $283,696, respectively, in the post-LT arm. In the DCC analysis, the pre-LT treatment strategy resulted in 9.27 per-patient quality-adjusted life years and $304,800 per patient lifetime costs versus 8.7 and $283,789, respectively, in the post-LT arm. As such, the pre-LT treatment strategy was found to be the most cost-effective in both populations with an incremental cost-effectiveness ratio of $74,255 (HCC) and $36,583 (DCC). Sensitivity and scenario analyses showed that results were most sensitive to the utility of patients post-LT, treatment sustained virological response rates, LT costs, and baseline Model for End-Stage Liver Disease score (DCC analysis only). The timing of initiation of antiviral treatment for HCV patients with HCC or DCC relative to LT is an important area of clinical and policy research; our results indicate that pre-LT treatment with a highly effective, all-oral DAA regimen provides the best health outcomes and is the most cost-effective strategy for the treatment of HCV patients with HCC or DCC waitlisted for LT. (Hepatology 2017;66:46-56). © 2017 by the American Association for the Study of Liver Diseases.

Rate of employment after liver transplantation in France: a single-centre study.

PubMed

Rudler, Marika; Rousseau, Géraldine; Lebray, Pascal; Méténier, Océane; Vaillant, Jean-Christophe; Savier, Eric; Eyraud, Daniel; Poynard, Thierry; Thabut, Dominique

2016-02-01

A return to gainful employment is an important outcome parameter after liver transplantation (LT). A recent study in the USA has shown a very high rate of unemployment after LT (75%). To date, there are no available data in France, where the public health insurance programme guarantees financial protection for everyone. The aim of this study was to assess the employment rate after LT in a French LT centre and to determine factors associated with employment after LT. All patients who had undergone liver transplantation at our centre between January 2000 and April 2011 and who met the following criteria responded to a questionnaire: (i) between 18 and 65 years old at the time of LT, (ii) alive 1 year after LT, (iii) alive, not retired and released from the hospital at the time of survey, (iv) French residents who were affiliated with French national health insurance. A total of 345 LTs were performed in 314 patients during the study period. Of the patients, 109 were excluded from the study: 23 had died within the first year after LT, 28 had died at the time of the survey, three were still in the hospital, seven were living in a foreign country, 11 had retired and 37 were older than 65 years after LT. Two hundred five patients were included in the study. The response rate was 76.6% (157/205). Patients responded a mean 6.1 ± 0.9 years after LT, 77.7% were French nationals, 73.2% were men, and the mean age at LT was 48.8 ± 9.9 years. The aetiologies of liver disease were as follows: alcohol 32.5%, hepatitis C 26.1%, alcohol and hepatitis C 3.8%, hepatitis B 15.3%, biliary cirrhosis 5.1%, autoimmune 2.5% and other causes 14.7%. Two years after LT, 43.3% of patients were employed. The demographic variables associated with post-LT employment were male sex (P<0.001), age under 40 years at LT (P=0.02), a sedentary job (P=0.007), raising children under the age of 18 years at the time of LT (P=0.01), a high level of education (P=0.001), not being affiliated with the French universal health coverage or 'CMU' (P=0.001). Only 53.3% of the patients who did not return to work after LT stated that they felt like they had a physical disability. The rate of return to work after LT in France was 43.1%, which was higher than that reported in the US study. However, this rate remains low and policies supporting return to work are needed to help liver recipients who wish to work after LT.

KSC-07pd3078

NASA Image and Video Library

2007-11-02

KENNEDY SPACE CENTER, FLA. -- During a rehearsal, Brig. Gen. Susan J. Helms, Commander of the 45th Space Wing at Patrick Air Force Base, makes a few comments to kick off the World Space Expo Aerial Salute at NASA's Kennedy Space Center. ): Commemorating humanity's first 50 years in space while looking forward to returning people to the moon and exploring beyond, the expo will showcase various panels, presentations and educational programs, as well as the air show. Participating in the air show are the U.S. Air Force Thunderbirds, U.S. Air Force F-22 Raptor, U.S. Navy F-18 Super Hornet, U.S. Air Force F-15 Eagle, the P-51 Mustang Heritage Flight, and the U.S. Air Force 920th Rescue Wing, which was responsible for Mercury and Gemini capsule recovery. The U.S. Army Golden Knights will also demonstrate precision skydiving. Photo credit: NASA/George Shelton

Human T-lymphotropic virus type I tax regulates the expression of the human lymphotoxin gene.

PubMed

Tschachler, E; Böhnlein, E; Felzmann, S; Reitz, M S

1993-01-01

Human T-lymphotropic virus type-I (HTLV-I)-infected T-cell lines constitutively produce high levels of lymphotoxin (LT). To analyze the mechanisms that lead to the expression of LT in HTLV-I-infected cell lines, we studied regulatory regions of the human LT promoter involved in the activation of the human LT gene. As determined by deletional analysis, sequences between +137 and -116 (relative to the transcription initiation site) are sufficient to direct expression of a reporter gene in the HTLV-I-infected cell line MT-2. Site-directed mutation of a of the single kappa B-like motif present in the LT promoter region (positions -99 to -89) completely abrogated LT promoter activity in MT-2 cells, suggesting that this site plays a critical role in the activation of the human LT gene. Transfection of LT constructs into HTLV-I-uninfected and -unstimulated Jurkat and U937 cell lines showed little to no activity of the LT promoter. Cotransfection of the same constructs with a tax expression plasmid into Jurkat cells led to detectable promoter activity, which could be significantly increased by stimulation of the cells with phorbol myristate acetate (PMA). Similarly, cotransfection of the LT promoter constructs and the tax expression plasmid into U937 cells led to significant promoter activity upon stimulation with PMA. These data suggest that HTLV-I tax is involved in the upregulation of LT gene expression in HTLV-I-infected cells.

Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

PubMed

Vance, David J; Greene, Christopher J; Rong, Yinghui; Mandell, Lorrie M; Connell, Terry D; Mantis, Nicholas J

2015-12-01

Type II heat-labile enterotoxins (HLTs) constitute a promising set of adjuvants that have been shown to enhance humoral and cellular immune responses when coadministered with an array of different proteins, including several pathogen-associated antigens. However, the adjuvant activities of the four best-studied HLTs, LT-IIa, LT-IIb, LT-IIb(T13I), and LT-IIc, have never been compared side by side. We therefore conducted immunization studies in which LT-IIa, LT-IIb, LT-IIb(T13I), and LT-IIc were coadministered by the intradermal route to mice with two clinically relevant protein subunit vaccine antigens derived from the enzymatic A subunit (RTA) of ricin toxin, RiVax and RVEc. The HLTs were tested with low and high doses of antigen and were assessed for their abilities to stimulate antigen-specific serum IgG titers, ricin toxin-neutralizing activity (TNA), and protective immunity. We found that all four HLTs tested were effective adjuvants when coadministered with RiVax or RVEc. LT-IIa was of particular interest because as little as 0.03 μg when coadministered with RiVax or RVEc proved effective at augmenting ricin toxin-specific serum antibody titers with nominal evidence of local inflammation. Collectively, these results justify the need for further studies into the mechanism(s) underlying LT-IIa adjuvant activity, with the long-term goal of evaluating LT-IIa's activity in humans. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Increased Requirement of Replacement Doses of Levothyroxine Caused by Liver Cirrhosis.

PubMed

Benvenga, Salvatore; Capodicasa, Giovanni; Perelli, Sarah; Ferrari, Silvia Martina; Fallahi, Poupak; Antonelli, Alessandro

2018-01-01

Since hypothyroidism is a fairly common dysfunction, levothyroxine (L-T4) is one of the most prescribed medications. Approximately 70% of the administered L-T4 dose is absorbed. The absorption process takes place in the small intestine. Some disorders of the digestive system and some medicines, supplements, and drinks cause L-T4 malabsorption, resulting in failure of serum TSH to be normal. Only rarely liver cirrhosis is mentioned as causing L-T4 malabsorption. In this study, we report increased requirement of daily doses of l-thyroxine in two patients with the atrophic variant of Hashimoto's thyroiditis and liver cirrhosis. In one patient, this increased requirement could have been contributed by the increased serum levels of the estrogen-dependent thyroxine-binding globulin (TBG), which is the major plasma carrier of thyroid hormones. In the other patient, we switched from tablet L-T4 to liquid L-T4 at the same daily dose. Normalization of TSH levels was achieved, but TSH increased again when she returned to tablet L-T4. Liver cirrhosis can cause increased L-T4 requirements. In addition to impaired bile secretion, the mechanism could be increased serum TBG. A similar increased requirement of L-T4 is observed in other situations characterized by elevation of serum TBG. Because of better intestinal absorption, L-T4 oral liquid formulation is able to circumvent the increased need of L-T4 in these patients.

Analysis of Air Force Junior Aircraft Maintenance Officer Leadership Development

DTIC Science & Technology

1985-09-01

research. ii I owe a lasting debt of gratitude to my parents . I thank my father, Lt Col Arthur C. Morabito, for his con- stant example of leadership...Conversely, second lieutenants are frequently overprotected by their superiors and thus are not allowed to learn through experience. (Wellins and others...Executive Committee 2 3.4 Chamber of Commerce Member 1 1.7 PTA Member 1 1.7 Career Day Representative 1 1.7 Amateur Theater Director 1 1.7 Single Parent

Adaptive Robust Estimation of Location and Scale Parameters of Symmetric Populations.

DTIC Science & Technology

1978-09-01

theses , wh i ch reported the results of a smdll Monte Carlo study of the performances of va rious estimators . The authors wish to thank Lt Michael...Leon (1972). The Method of Least Squares and Some Al ternatives. AR!, TR 72—129 , Aer ospace Res ear ch Lab oratories , Wr ight—Patterson Air Force...5287 .8556 .7875 .7260 .5299 .8489 . 7845 .7242 (c) .9515 .6362 .2920 .4900 .9492 .6205 .2872 .4789 (d)(l) .6147 .8222 .6007 .6846 .6219 .8230 .6014

Design and Testing of an H2/O2 Predetonator for a Simulated Rotating Detonation Engine Channel

DTIC Science & Technology

2013-03-01

Diameter PDE Pulse Detonation Engines RDE Rotating Detonation Engine WPAFB Wright Patterson Air Force Base ZND Zeldovich, von Neumann and Doring xv...DESIGN AND TESTING OF AN H2/O2 PREDETONATOR FOR A SIMULATED ROTATING DETONATION ENGINE CHANNEL THESIS Stephen J. Miller, 2Lt, USAF AFIT-ENY-13-M-23...RELEASE; DISTRIBUTION UNLIMITED AFIT-ENY-13-M-23 DESIGN AND TESTING OF AN H2/O2 PREDETONATOR FOR A SIMULATED ROTATING DETONATION ENGINE CHANNEL Stephen

Light Infantry: A Tactical Deep Battle Asset for Central Europe.

DTIC Science & Technology

1985-12-02

that overview siptgficant lessons will be extracted with a view toward modern day applicability. A brief review of current capabilities for U. S. o...Genral Boldin wrote about a forty-five day operation in the enemy’s rear in which he establisad caummications with friendly forces and was able to...between the lessons extracted above n the hb fits of deep battle operations identified by LT Holder. lie contends that the principal benefLts of d v-p

Space Resilience and the Contested, Degraded, and Operationally Limited Environment: The Gaps in Tactical Space Operations

DTIC Science & Technology

2014-12-01

Operationally Limited Environment The Gaps in Tactical Space Operations Capt Bryan M. Bell , USAF 2d Lt Even T. Rogers, USAF The ability of space...David S. Fadok, “John Boyd and John Warden: Airpower’s Quest for Strategic Paralysis ,” in The Paths of Heaven: The Evolution of Airpower Theory, ed...Warden,” 365. Capt Bryan M. Bell , USAF Captain Bell (BS, University of Florida; MS, Air Force Institute of Technology) is assistant operations officer and

Army - Air Force Cooperation: Looking Backward to Move Forward

DTIC Science & Technology

2016-05-26

ELEMENT NUMBER 6. AUTHOR(S) Lt Col Eric A. Smith 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS...ES) School of Advanced Military Studies, U.S. Army Command and General Staff College 201 Reyolds Ave., Fort Leavenworth, KS 66027 8. PERFORMING ORG...dispute, the Joint Chiefs of Staff directed US Strike Command to independently test the Army’s new mobility concepts performed separately by both the Army

Effect of Topography on Learning Military Tactics - Integration of Generalized Intelligent Framework for Tutoring (GIFT) and Augmented REality Sandtable (ARES)

DTIC Science & Technology

2016-09-01

Generalized Intelligent Framework for Tutoring (GIFT) and Augmented REality Sandtable ( ARES ) by Michael W Boyce, Ramsamooj J Reyes, Deeja E Cruz, Charles...NOTICES Disclaimers The findings in this report are not to be construed as an official Department of the Army position unless so designated by...REality Sandtable ( ARES ) by Michael W Boyce Oak Ridge Associated Universities, Oak Ridge, TN LT COL Ramsamooj J Reyes Air Force Institute of

GPS - A PostScript-Like Language for System Simulation

DTIC Science & Technology

1991-01-01

Force Systems Command Edwards AFB CA 93523-5000 9! 2,3 092 NOTICE When U.S. Government drawings, specifications, or other data are used for any purpose...the said drawings, specifica- tions, or other data , is not to be regarded by implication or otherwise, or in any way licensing the holder or any other...United States Department of Energy under Contract W-31-109-Eng-38. OLAC PL Project Manager was Lt Tim Lawrence. This-report has been reviewed and is

Naval War College Review, Volume 59, Number 4, Autumn 2006

DTIC Science & Technology

2006-01-01

strong defen- sive structure. Fort Fisher lies on a peninsula jutting south from Wilmington in what looks like an elon - gated and inverted pyramid...had been blocked since May in the Bermuda Hundred, a bight of land enclosed by a loop of the James River about twenty miles south of the city. C:\\WIP... Muske - teer, November 27, 1956 [hereafter Air Task Force Report], TNA, PRO, p. 2; Lt. Cdr. Roy Everleigh, RN, quoted in Brian Cull, David Nicolle, and

Field Observations and SWAN Model Predictions of Wave Evolution in a Muddy Coastal Environment

DTIC Science & Technology

2009-06-01

Dr. John Trowbridge and Dr. Janet Fredericks at Woods Hall Oceanographic Institute (WHOI) for supplying the wind data for the experim ent. Thanks...the sea to ward power projection and the em ployment of naval forces from the sea to influence events in the littoral regions of the world”. This...and toward projecting power and influence in regional areas. As a resu lt many countries now focus their efforts on a greater understanding of the

Operating Below Crush Depth: The Formation, Evolution, and Collapse of the Imperial Japanese Navy Submarine Force in World War II

DTIC Science & Technology

2011-06-10

Subamrine, Medium) LCDR Lieutenant Commander LT Lieutenant NM Nautical Mile RADM Rear Admiral ST Sen- Taka (Submarine, High Speed) STo Sen-Toku...Special Submarine) STS Sen- Taka -Sho (Submarine, High Speed(Victory)) USS United States Ship VADM Vice Admiral 1 CHAPTER 1 INTRODUCTION On...Kirai-Sen meaning Mine-Layer, KT for Kai-Toku-Chu meaning Medium, Special Submarine, ST for Sen- Taka meaning Submarine, High speed, STo for Sen Toku

An Analysis of the Populations of the Air Force’s Medical and Professional Officer Corps

DTIC Science & Technology

2010-01-01

since 1978. (See pp. 3–4.) Since 1978, the Chaplain and Dental Corps have declined in rough parallel to the Air Force’s overall active-duty...prior to entering the medical and professional corps has been most common in the MSC and BSC and least common in the Dental Corps. Attrition between...interpretation to those statuses and trends. (See pp. 33–34.) xv Acknowledgments The authors appreciate the assistance of John Park, Lt Col William

United States Air Force Summer Faculty Research Program 1989. Program Technical Report. Volume 3

DTIC Science & Technology

1989-12-01

doppler broadened transitions by Holstein12 . We have used the functional form of Holstein and incorporated the 30 % increase 13 suggested by Phelps g...impact excitation of the 4 D level",J.Phys.B.,7,pp.2003-2020,1974. 12. T. Holstein ,"Imprisonment of Resonance Radiation in Gases. II",Physical Rev.,83...Backward Propagation Network FUNCTIONAL LINK NETWORKS Output Layer Devce ovice’lt one mNtdtq Camer Cowe . Oopng Corlc Functional MBE Input Characteristics

Practical Applications of Math and Science in Junior High Schools

DTIC Science & Technology

1984-04-01

APPLICATIONS OF MATH AND SCIENCE IN JUNIOR HIGH SCHOOLS AUTHOR(S) MAJOR LAWRENCE N. HYLAND, USAF FACULTY ADVISOR mAJoR JAMM WILSON, ACSC/EDDP SPONSOR LT COL...JUNIOR HIGH SCHOOLS 6 PERFORMING O1G. REPORT NUMBER "ś, Au THORrs) 8. CON’RACT OR GRANT NUMBER(.,) Lawrence N. Hyland, Major, USAF 9. PERFORMING...materials aimed at the jumior high school level. Material exposes target group to the mathematical and scientific skills required of Air Force

Report of Operation Fitzwilliam. Volume 4 (REDACTED)

DTIC Science & Technology

1952-10-01

notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not...19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...aecretar,y Jir Force Personn§l Capt. G. E. D&~1 Lt. W. E. Petigo . S/Sgt. E. A~ Anderson Sgt. Pilao,n Sgt. : aaker Sgt, G. .A.d.ama Sgt. JobAaon

Air Force Human Resources Laboratory Annual Report Fiscal Year 1984,

DTIC Science & Technology

1985-07-01

Wilbourn AFHRL/MOAE AFHRL/MOAE Brooks AFB, TX 78235-5000 Brooks AFB, TX 78235-5000 Commercial (512) 536-3256 Commercial (512) 536-3256 AUTOVON 240-3256...the-job training. Dr Joseph Yasutake Technical Advisor 142 .-m -- m Immmm ..jmmmmm mm mmmmmmm1mm n m COMMAND STAFF PERSONNEL - e Mr. Robert L. lady...initial big-step improvements can be made. The subthrusts have been the subject of unusually Lt Col Joseph A. Dirt high-level interest. Special scientific

JPRS Report, Soviet Union, Military History Journal, No. 9, September 1987

DTIC Science & Technology

1988-03-10

The company party organizer, Lt S.F. Makeyev , wrote out a leaflet. It stated: "Today, having shown courage and heroism, Komsomol member Ivan... magic effect. The fleeing soldiers returned to their places and by their accurate fire forced the enemy infantry which has risen for the assault to...pp 76-81) Partisan Actions in the Patriotic War of 1812 (V.A. Yevlanov)(pp 82- 85 ) Military Activities of Mustafa Kemal Ataturk (V.O. Daynes)(pp 86

Air Intelligence and the Search for the Center of Gravity

DTIC Science & Technology

1988-04-01

co inAIR INTELLIGENCE AND THE 0) ~ SEARCH FOR THE CENTER OF GRAVITY F LT COL CHARLES N. CULBERTSON 1988 - .- ,------.--.- Non VL AIR UNIVERSITY RLlo...During the 1930’s the future air commanders in the Air Corps’ primary doctrinal think tank, The Air Corps Tactical School, at Maxwell Field, took this...conversation with Speer after the war General Ira Eaker, the former commander of the 6th Air Force (8 AF was the AAF’s primary strategic striking arm in

Strategic Studies Quarterly, Volume 4, Number 3, Fall 2010

DTIC Science & Technology

2010-01-01

Story of the Aum Doomsday Cult, from the Subways of Tokyo to the Nuclear Arsenals of Russia (New York: Crown Publishers, 1996 ), 108-12. 32. Lt Col John...Attraction," Journal of Personality andSocial Psychology󈨊, no. 2 (February 1996 ). 26. As Siebold and Lindsay put it, "A central tenet of current [1999...Ralph M. Carney, eds., Out in Force: Sexual Orientation and the Miliuiry (Chicago: University of Chicago Press, 1996 ), 166. 29. Om Prakash, "The

Environmental Impact Statement. Disposal and Reuse of Mather Air Force Base, California

DTIC Science & Technology

1992-04-01

and Lt Col Bartol nave finished their presentations and e have you entered the hearing room tonight. The findings of that study as presented a recess...situ, but you rhe conments that you made with reference to transportation and the f ’ow of gave as some worthy comeents as to your ideas about the matter ...and whole matter of base closure. Thank you . we thnk yo for that And a lot of people including Assemblyman Consely, who is State Assemblymagn a d

Sequential Testing of Hypotheses Concerning the Reliability of a System Modeled by a Two-Parameter Weibull Distribution.

DTIC Science & Technology

1981-12-01

CONCERNING THE RELIABILITY OF A SYSTEM MODELED BY A TWO-PARAMETER WEIBULL DISTRIBUTION THESIS AFIT/GOR/MA/81D-8 Philippe A. Lussier 2nd Lt USAF... MODELED BY A TWO-PARAMETER WEIBULL DISTRIBUTION THESIS Presented to the Faculty of the School of Engineering of the Air Force Institute of Technology...repetitions are used for these test procedures. vi Sequential Testing of Hypotheses Concerning the Reliability of a System Modeled by a Two-Parameter

33 CFR Schedule II to Subpart A of... - Table of Speeds 1

Code of Federal Regulations, 2012 CFR

2012-07-01

.... III Col. IV 1. Upper Entrance, South Shore Canal Lake St. Louis, Buoy A13 10.5 10.5. 2. Lake St. Louis.... Eisenhower Lock Iroquois Lock 11.5 10.5. 7. Iroquois Lock McNair Island, Lt. 137 13 10.5. 8. McNair Island, Lt. 137 Deer Island, Lt. 186 11.5 10.5. 9. Deer Island, Lt. 186 Bartlett Point, Lt. 227 8.5 upb; 10.5...

Plasma protein biomarkers enhance the clinical prediction of kidney injury recovery in patients undergoing liver transplantation.

PubMed

Levitsky, Josh; Baker, Talia B; Jie, Chunfa; Ahya, Shubhada; Levin, Murray; Friedewald, John; Al-Saden, Patrice; Salomon, Daniel R; Abecassis, Michael M

2014-12-01

Biomarkers predictive of recovery from acute kidney injury (AKI) after liver transplantation (LT) could enhance decision algorithms regarding the need for liver-kidney transplantation or renal sparing regimens. Multianalyte plasma/urine kidney injury protein panels were performed immediately before and 1 month post-LT in an initial test group divided by reversible pre-LT AKI (rAKI = post-LT renal recovery) versus no AKI (nAKI). This was followed by a larger validation set that included an additional group: irreversible pre-LT AKI (iAKI = no post-LT renal recovery). In the test group (n = 16), six pre-LT plasma (not urine) kidney injury proteins (osteopontin [OPN], neutrophil gelatinase-associated lipocalin, cystatin C, trefoil factor 3, tissue inhibitor of metalloproteinase [TIMP]-1, and β-2-microglobulin) were higher in rAKI versus nAKI (P < 0.05) and returned to normal values with renal recovery post-LT. In the validation set (n = 46), a number of proteins were significantly higher in both rAKI and iAKI versus nAKI. However, only pre-LT plasma OPN (P = 0.009) and TIMP-1 (P = 0.019) levels were significantly higher in rAKI versus iAKI. Logistic regression modeling was used to correlate the probability of post-LT rAKI, factoring in both pre-LT protein markers and clinical variables. A combined model including elevated OPN and TIMP-1 levels, age <57, and absence of diabetes had the highest area under the curve of 0.82, compared to protein-only and clinical variable-only models. These data suggest that plasma protein profiles might improve the prediction of pre-LT kidney injury recovery after LT. However, multicenter, prospective studies are needed to validate these findings and ultimately test the value of such protein panels in perioperative management and decision making. © 2014 by the American Association for the Study of Liver Diseases.

Toll-Like Receptor 2 Mediates Cellular Activation by the B Subunits of Type II Heat-Labile Enterotoxins

PubMed Central

Hajishengallis, George; Tapping, Richard I.; Martin, Michael H.; Nawar, Hesham; Lyle, Elizabeth A.; Russell, Michael W.; Connell, Terry D.

2005-01-01

The type II heat-labile enterotoxins (LT-IIa and LT-IIb) of Escherichia coli have an AB5 subunit structure similar to that of cholera toxin (CT) and other type I enterotoxins, despite significant differences in the amino acid sequences of their B subunits and different ganglioside receptor specificities. LT-II holotoxins and their nontoxic B subunits display unique properties as immunological adjuvants distinct from those of CT and its B subunits. In contrast to type II holotoxins, the corresponding pentameric B subunits, LT-IIaB and LT-IIbB, stimulated cytokine release in both human and mouse cells dependent upon Toll-like receptor 2 (TLR2). Induction of interleukin-1β (IL-1β), IL-6, IL-8, or tumor necrosis factor alpha in human THP-1 cells by LT-IIaB or LT-IIbB was inhibited by anti-TLR2 but not by anti-TLR4 antibody. Furthermore, transient expression of TLR1 and TLR2 in human embryonic kidney 293 cells resulted in activation of a nuclear factor-κB-dependent luciferase gene in response to LT-IIaB or LT-IIbB. Moreover, peritoneal macrophages from TLR2-deficient mice failed to respond to LT-IIaB or LT-IIbB, in contrast to wild-type or TLR4-deficient cells. These results demonstrate that besides their established binding to gangliosides, the B subunits of type II enterotoxins also interact with TLR2. Although a ganglioside-nonbinding mutant (T34I) of LT-IIaB effectively induced cytokine release, a phenotypically similar point mutation (T13I) in LT-IIbB abrogated cytokine induction, suggesting a variable requirement for gangliosides as coreceptors in TLR2 agonist activity. TLR2-dependent activation of mononuclear cells by type II enterotoxin B subunits appears to be a novel mechanism whereby these molecules may exert their immunomodulatory and adjuvant activities. PMID:15731031

Histogram and gray level co-occurrence matrix on gray-scale ultrasound images for diagnosing lymphocytic thyroiditis.

PubMed

Shin, Young Gyung; Yoo, Jaeheung; Kwon, Hyeong Ju; Hong, Jung Hwa; Lee, Hye Sun; Yoon, Jung Hyun; Kim, Eun-Kyung; Moon, Hee Jung; Han, Kyunghwa; Kwak, Jin Young

2016-08-01

The objective of the study was to evaluate whether texture analysis using histogram and gray level co-occurrence matrix (GLCM) parameters can help clinicians diagnose lymphocytic thyroiditis (LT) and differentiate LT according to pathologic grade. The background thyroid pathology of 441 patients was classified into no evidence of LT, chronic LT (CLT), and Hashimoto's thyroiditis (HT). Histogram and GLCM parameters were extracted from the regions of interest on ultrasound. The diagnostic performances of the parameters for diagnosing and differentiating LT were calculated. Of the histogram and GLCM parameters, the mean on histogram had the highest Az (0.63) and VUS (0.303). As the degrees of LT increased, the mean decreased and the standard deviation and entropy increased. The mean on histogram from gray-scale ultrasound showed the best diagnostic performance as a single parameter in differentiating LT according to pathologic grade as well as in diagnosing LT. Copyright © 2016 Elsevier Ltd. All rights reserved.

Recent advances in nontoxic Escherichia coli heat-labile toxin and its derivative adjuvants.

PubMed

Ma, Yongping

2016-11-01

The nontoxic heat-labile enterotoxin (LT) of Escherichia coli and the B subunit of LT (LTB) have been extensively studied as potent vaccine adjuvants. Areas covered: This review covers the area of enterotoxin based vaccine adjuvant and summarizes the development of nontoxic LT mutant (mLT) and LTB and their potency as oral, parenteral and injection adjuvants. Recent evidences indicated that the mechanism of LTB adjuvanticity was to enhance the turnover of dendritic cells (DCs) in spleen and increase DCs capacity to perform as antigen presentation cells (APCs) encountered with T cells. LTB also induces B and T cells clustering and delay/arrest in T-cell division following endocytosis or B-cell receptor (BCR) uptaking of antigen in a ganglioside-mediated manner. Expert commentary: It is pointed out that the immunogenicity of LTB (or LT) is more important than the receptor binding property (or ADP-ribosylation activity) for the adjuvanticity of LT toxoid. The immunogenicity of LTB (or LT) might confer unknown characteristics to maintain LT toxoid adjuvanticity.

Treatment of complex airway lesions after lung transplantation with self-expandable nitinol stents: early experience.

PubMed

Anile, M; Venuta, F; Diso, D; Liparulo, V; Ricella, C; De Giacomo, T; Pugliese, F; Rolla, M; Quattrucci, S; Pecoraro, Y; Rendina, E A; Coloni, G F

2010-05-01

Airway complications (AC) are considered a serious cause of morbidity after lung transplantation (LT). Mechanical dilatation, laser vaporization, and silicone stent placement usually solve it. However, the use of self-expandable metallic stents (SENS) may be indicated in selected cases. Ten lung transplant recipients with AC were treated with SENS. Six patients underwent LT for cystic fibrosis, 2 for idiopathic pulmonary fibrosis, 1 for bronchiectasis, and 1 for emphysema. All patients received at least 1 treatment attempt with dilatation and silicone stent placement. The indications for SENS placement were the presence of a tortuous airway axis with stenosis and malacia of the right main bronchus in 5 patients; a long stenosis of the main and intermediate right bronchus involving the upper lobe orifice in 3 patients; or malacia that could not be stabilized with silicone stents in 3 cases. In 1 patient the procedure was bilateral. Functional improvement was immediate with a mean forced expiratory volume at 1 second (FEV(1)) gain of 35%. No stent dislocation was observed. Symptoms did not occur again in 5 patients with previous recurrent episodes of pneumonia. One stenosis, which was due to the ingrowth of granulation tissue occurred at 6 months after the procedure, was successfully treated with mechanical dilatation and laser vaporization. The deployment of SENS in a selected group of patients with AC after LT was easy, safe, and effective. Copyright (c) 2010 Elsevier Inc. All rights reserved.

A Two-Dimensional Unsteady Method of Characteristics Analysis of Fluid Flow Problems - MCDU 43

DTIC Science & Technology

1975-07-01

N)>ZBN(KtLfHnt .(RBHIK.L+ltMJ-RBHfK.LtN))) ZPR«-(RMA-RBM(KvLtP))*SINtANGLEU .(ZMA-ZBH(KtLtMn*COS(ANGLE) BPp = (PMA-RPMIK,L,M))*CCS(ANr,LFI*(ZMA...INDEX»INOEX+1 IF(INDEX.LT.25)GO TO 1010 WRITE(6,8700)1,J CALL PRINT 101 fAU EXIT lOtn IF(NrnilNT,FO.llGn TH HOO TTFST-l STORF P

Clearance of hepatitis C virus after living-donor liver transplantation in spite of residual viremia on end date of interferon therapy before transplantation

PubMed Central

Ichikawa, Tatsuki; Nakao, Kazuhiko; Hamasaki, Keisuke; Honda, Takuya; Shibata, Hidetaka; Akahoshi, Mana; Eguchi, Susumu; Takatsuki, Mitsuhisa; Kanematsu, Takashi; Eguchi, Katsumi

2007-01-01

Interferon (IFN) therapy is the only treatment strategy for hepatitis C virus (HCV) infection after liver transplantation (LT), but prophylactic and treatable IFN therapy after LT has been shown to be insufficient due to the adverse effects of IFN and rivabirin. In this paper, we describe the disappearance of HCV after LT without IFN therapy in the presence of residual viremia on the day of LT. We herein report our findings since this is considered an important case for the anti-HCV strategy of post LT. A 60-year old woman with LC and HCC was referred to Nagasaki University Hospital in August 2004. After she underwent LT on February 18, 2005, we injected peg-IFN-α-2a the 11th time at 18 wk and HCV-RNA was still positive in the serum at LT. The serum HCV-RNA was negative one month after operation and subsequently dissolved 15 mo after operation without IFN therapy. As a result, we speculate that if HCV-RNA is positive while HCV core antigen is negative before LT, then it may lead to clearance of HCV after LT. Therefore long acting peg-IFN-α-2a is thus considered a potentially effective agent for the treatment of HCV-related cirrhosis before LT. PMID:17696240

Nationwide surveillance of circulatory collapse associated with levothyroxine administration in very-low-birthweight infants in Japan.

PubMed

Kawai, Masahiko; Kusuda, Satoshi; Cho, Kazutoshi; Horikawa, Reiko; Takizawa, Fumihiko; Ono, Makoto; Hattori, Tetsuo; Oshiro, Makoto

2012-04-01

Although the administration of levothyroxine sodium (LT4) to premature infants had been considered safe, several cases of late-onset circulatory collapse (LCC) following the administration of LT4 in very-low-birth-weight (VLBW) infants have been reported in Japan since 2008. This study was performed to investigate the incidence of LCC associated with the administration of LT4 to VLBW infants. A questionnaire regarding LCC with or without an association with LT4 administration in VLBW infants from 2006 to 2008, was sent to 212 hospitals belonging to the Japan Neonatologist Association. Data of 8727 VLBW infants were analyzed, and 46 cases of LCC associated with the administration of LT4 were reported in this surveillance. Especially, an analysis for infants weighing between 1000 and 1499 g at birth revealed that the incidence of LCC with the administration of LT4 was higher than that of those without LT4. LT4 is widely used for infants, including VLBW infants, and no major complications have been reported. However, our study revealed that more than a few cases of LCC were associated with the administration of LT4 in VLBW infants. In conclusion, careful attention is necessary when initiating the administration of LT4 to VLBW infants. © 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.

Site occupancy, composition and magnetic structure dependencies of martensitic transformation in Mn₂Ni_1+xSn_1-x.

PubMed

Kundu, Ashis; Ghosh, Subhradip

2017-11-14

A delicate balance between various factors such as site occupancy, composition and magnetic ordering seems to affect the stability of the martensitic phase in Mn₂Ni_1+xSn_1-x. Using first-principles DFT calculations, we explore the impacts of each one of these factors on the martensitic stability of this system. Our results on total energies, magnetic moments and electronic structures upon changes in the composition, the magnetic configurations and the site occupancies show that the occupancies at the 4d sites in the Inverse Heusler crystal structure play the most crucial role. The presence of Mn at the 4d sites originally occupied by Sn and its interaction with the Mn atoms at other sites decide the stability of the martensitic phases. This explains the discrepancy between the experiments and earlier DFT calculations regarding phase stability in Mn₂NiSn. Our results qualitatively explain the trends observed experimentally with regard to martensitic phase stability and the magnetisations in Ni-excess, Sn-deficient Mn₂NiSn system. © 2017 IOP Publishing Ltd.

Obesity after pediatric liver transplantation: prevalence and risk factors.

PubMed

Sundaram, Shikha S; Alonso, Estella M; Zeitler, Phil; Yin, Wanron; Anand, Ravinder

2012-12-01

Pediatric obesity has become a significant public health concern. The historical focus in pediatric liver transplant (LT) has been undernutrition, with limited knowledge regarding obesity. Therefore, we sought to determine the prevalence of obesity in pediatric LT, compare it to National Health and Nutrition Examination Surveys (NHANES) data, and identify risk factors for obesity in pediatric LT. SPLIT, which collects pediatric LT data at 39 centers, was queried for subjects ages 2 to 18 years at follow-up, LT between 1995 and 2007, and with at least 1 body mass index measured 1 to 5 years after LT. Of 1706 individuals included, 44% had biliary atresia (47% boys, 58% white, mean age at LT 4.6 years). Of these individuals, 19% were obese at 1 year and 18% at 3 years, higher than in the general pediatric population reported by 2003-2004 NHANES, whereas 11% obesity at 5 years after LT was similar to NHANES data. Using logistic regression, Hispanic ethnicity (odds ratio [OR] 1.8, 95% confidence interval [CI] 1.19-2.23), steroid use at follow-up (OR 1.48, 95% CI 1.23-1.77), overweight (OR 4.34, 95% CI 2.91-6.68), and obesity (OR 10.62, 95% CI 5.9-19.65) at LT independently predicted post-LT obesity. These findings suggest a need to broaden standard care to include obesity assessment and intervention in routine pre- and posttransplant care.

Retraining walking adaptability following incomplete spinal cord injury.

PubMed

Fox, Emily J; Tester, Nicole J; Butera, Katie A; Howland, Dena R; Spiess, Martina R; Castro-Chapman, Paula L; Behrman, Andrea L

2017-01-01

Functional walking requires the ability to modify one's gait pattern to environmental demands and task goals-gait adaptability. Following incomplete spinal cord injury (ISCI), gait rehabilitation such as locomotor training (Basic-LT) emphasizes intense, repetitive stepping practice. Rehabilitation approaches focusing on practice of gait adaptability tasks have not been established for individuals with ISCIs but may promote recovery of higher level walking skills. The primary purpose of this case series was to describe and determine the feasibility of administering a gait adaptability retraining approach-Adapt-LT-by comparing the dose and intensity of Adapt-LT to Basic-LT. Three individuals with ISCIs (>1 year, AIS C or D) completed three weeks each (15 sessions) of Basic-LT and Adapt-LT. Interventions included practice on a treadmill with body weight support and practice overground (≥30 mins total). Adapt-LT focused on speed changes, obstacle negotiation, and backward walking. Training parameters (step counts, speeds, perceived exertion) were compared and outcomes assessed pre and post interventions. Based on completion of the protocol and similarities in training parameters in the two interventions, it was feasible to administer Adapt-LT with a similar dosage and intensity as Basic-LT. Additionally, the participants demonstrated gains in walking function and balance following each training type. Rehabilitation that includes stepping practice with adaptability tasks is feasible for individuals with ISCIs. Further investigation is needed to determine the efficacy of Adapt-LT.

Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B.

PubMed

Paul, N L; Lenardo, M J; Novak, K D; Sarr, T; Tang, W L; Ruddle, N H

1990-11-01

Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of biologically active lymphotoxin (LT; tumor necrosis factor-beta) protein and LT mRNA. To understand the regulation of LT transcription by HTLV-I, we analyzed the ability of a series of deletions of the LT promoter to drive the chloramphenicol acetyltransferase (CAT) reporter gene in HTLV-I-positive MT-2 cells. The smallest LT promoter fragment (-140 to +77) that was able to drive CAT activity contained a site that was similar to the immunoglobulin kappa-chain NF-kappa B-binding site. Since the HTLV-I tax gene activates the nuclear form of NF-kappa B, this finding suggested a possible means of HTLV-I activation of LT production. We found that the LT kappa B-like site specifically formed a complex with NF-kappa B-containing nuclear extract from MT-2, C81-66-45, and other activated T cells. Mutation of the LT kappa B site in the context of the LT promoter (-293 to +77) (mutant M1) reduced the ability of the promoter to drive the CAT gene in HTLV-I-infected and noninfected human T-cell lines. These data suggest a general role for NF-kappa B activation in the induction of LT gene transcription. Activation of LT in HTLV-I-infected cells may explain the pathology associated with HTLV-I infection, including the hypercalcemia that is prevalent in adult T-cell leukemia.

Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B.

PubMed Central

Paul, N L; Lenardo, M J; Novak, K D; Sarr, T; Tang, W L; Ruddle, N H

1990-01-01

Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of biologically active lymphotoxin (LT; tumor necrosis factor-beta) protein and LT mRNA. To understand the regulation of LT transcription by HTLV-I, we analyzed the ability of a series of deletions of the LT promoter to drive the chloramphenicol acetyltransferase (CAT) reporter gene in HTLV-I-positive MT-2 cells. The smallest LT promoter fragment (-140 to +77) that was able to drive CAT activity contained a site that was similar to the immunoglobulin kappa-chain NF-kappa B-binding site. Since the HTLV-I tax gene activates the nuclear form of NF-kappa B, this finding suggested a possible means of HTLV-I activation of LT production. We found that the LT kappa B-like site specifically formed a complex with NF-kappa B-containing nuclear extract from MT-2, C81-66-45, and other activated T cells. Mutation of the LT kappa B site in the context of the LT promoter (-293 to +77) (mutant M1) reduced the ability of the promoter to drive the CAT gene in HTLV-I-infected and noninfected human T-cell lines. These data suggest a general role for NF-kappa B activation in the induction of LT gene transcription. Activation of LT in HTLV-I-infected cells may explain the pathology associated with HTLV-I infection, including the hypercalcemia that is prevalent in adult T-cell leukemia. Images PMID:1976820

Survival benefit of repeat liver transplantation in the United States: a serial MELD analysis by hepatitis C status and donor risk index.

PubMed

Biggins, S W; Gralla, J; Dodge, J L; Bambha, K M; Tong, S; Barón, A E; Inadomi, J; Terrault, N; Rosen, H R

2014-11-01

Survival benefit (SB) for first liver transplantation (LT) is favorable at Model for End-Stage Liver Disease (MELD)≥15. Herein, we identify the MELD threshold for SB from repeat liver transplantation (ReLT) by recipient hepatitis C virus (HCV) status and donor risk index (DRI). We analyzed lab MELD scores in new United Network for Organ Sharing registrants for ReLT from March 2002 to January 2010. Risk of ReLT graft failure≤1 year versus waitlist mortality was calculated using Cox regression, adjusting for recipient characteristics. Of 3057 ReLT candidates, 54% had HCV and 606 died while listed. There were 1985 ReLT recipients, 52% had HCV and 567 ReLT graft failures by 1 year. Unadjusted waitlist mortality and post-ReLT graft failure rates were 416 (95% confidence interval [CI] 384-450) and 375 (95% CI 345-407) per 1000 patient-years, respectively. Waitlist mortality was higher with increasing waitlist MELD (p<0.001). The MELD for SB from ReLT overall was 21 (21 in non-HCV and 24 in HCV patients). MELD for SB varied by DRI in HCV patients (MELD 21, 24 and 27 for low, medium and high DRI, respectively) but did not vary for non-HCV patients. Compared to first LT, ReLT requires a higher MELD threshold to achieve an SB resulting in a narrower therapeutic window to optimize the utility of scarce liver grafts. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

PmLT, a C-type lectin specific to hepatopancreas is involved in the innate defense of the shrimp Penaeus monodon.

PubMed

Ma, Tracy Hoi-Tung; Benzie, John A H; He, Jian-Guo; Chan, Siu-Ming

2008-11-01

A diverse class of proteins called lectins plays a major role in shrimp innate immunity. In this study, the cDNA encoding a C-type lectin of Penaeus monodon (PmLT) was cloned, and its potential role examined. Despite the low overall amino acid sequence identity with other animal lectins, PmLT includes conserved carbohydrate recognition domains (CRDs) characteristic of animal C-type lectins. Unlike the other two P. monodon lectin-like proteins described to date that have one CRD, PmLT has two CRDs. The first CRD contains a QPD motif with specificity for binding galactose, while the second CRD contains a EPN motif for binding mannose. PmLT transcripts can be detected in the hepatopancreas but not in other tissues. Expression studies showed that PmLT mRNA transcript level decreased initially and then gradually increased after whole shrimp or hepatopancreas tissue fragments were treated with white spot syndrome virus (WSSV) extract but were not affected by bacteria. Using anti-rPmLT antibody, PmLT was detected only in the hepatopancreas specific F cells (Hpf). In vitro encapsulation assay showed that agarose beads coated with rPmLT were encapsulated by hemocytes indicating a role in innate immune response. In summary, PmLT is produced in the hepatopancreas and may act as a pattern recognition protein for viral pathogens and also activates the innate immune responses of the shrimp to bacteria. The dual-CRD structure of PmLT may assist the recognition of diverse pathogens.

Detection of Special Operations Forces Using Night Vision Devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, C.M.

2001-10-22

Night vision devices, such image intensifiers and infrared imagers, are readily available to a host of nations, organizations, and individuals through international commerce. Once the trademark of special operations units, these devices are widely advertised to ''turn night into day''. In truth, they cannot accomplish this formidable task, but they do offer impressive enhancement of vision in limited light scenarios through electronically generated images. Image intensifiers and infrared imagers are both electronic devices for enhancing vision in the dark. However, each is based upon a totally different physical phenomenon. Image intensifiers amplify the available light energy whereas infrared imagers detectmore » the thermal energy radiated from all objects. Because of this, each device operates from energy which is present in a different portion of the electromagnetic spectrum. This leads to differences in the ability of each device to detect and/or identify objects. This report is a compilation of the available information on both state-of-the-art image intensifiers and infrared imagers. Image intensifiers developed in the United States, as well as some foreign made image intensifiers, are discussed. Image intensifiers are categorized according to their spectral response and sensitivity using the nomenclature of GEN I, GEN II, and GEN III. As the first generation of image intensifiers, GEN I, were large and of limited performance, this report will deal with only GEN II and GEN III equipment. Infrared imagers are generally categorized according to their spectral response, sensor materials, and related sensor operating temperature using the nomenclature Medium Wavelength Infrared (MWIR) Cooled and Long Wavelength Infrared (LWIR) Uncooled. MWIR Cooled refers to infrared imagers which operate in the 3 to 5 {micro}m wavelength electromagnetic spectral region and require either mechanical or thermoelectric coolers to keep the sensors operating at 77 K. LWIR Uncooled refers to infrared imagers which operate in the 8 to 12 {micro}m wavelength electromagnetic spectral region and do not require cooling below room temperature. Both commercial and military infrared sensors of these two types are discussed.« less

Obama Kennedy Space Center Visit

NASA Image and Video Library

2010-04-14

NASA Kennedy Space Center Director bob Cabana shakes hands with President Barack Obama as he and Gen. C. Robert Kehler, Commander, Air Force Space Command, left, welcome the President to Kennedy in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)

Airpower and the Battle of Khafji: Setting the Record Straight

DTIC Science & Technology

1998-06-01

DISTRIBUTION/AVAILABILITY STATEMENT A PUBLIC RELEASE , 13. SUPPLEMENTARY NOTES 14. ABSTRACT General Norman Schwarzkopf, Commander of...the US Government, Department of Defense, the United States Air Force, or Air University. iii ABSTRACT General Norman Schwarzkopf, Commander of...Commander Gen Norman Schwarzkopf directed Horner to shift the air campaign’s focus to the Iraqi Army— especially the Republican Guard. While some in the

The role of the ligamentum teres in the adult hip: redundant or relevant? A review

PubMed Central

Devitt, Brian M; Arora, Manit

2018-01-01

ABSTRACT The ligamentum teres (LT) has traditionally been described as a redundant structure with no contribution to hip biomechanics or function. There has been renewed interest in the LT as a source of hip pathology due to the high prevalence of LT pathology observed at the time of hip arthroscopy. The LT acts a secondary stabilizer to supplement the work of the capsular ligaments and works in a sling-like manner to prevent subluxation of the hip at the extremes of motion. The presence of free nerve endings within the LT indicates a definite role in pain generation, with the LT undergoing various mechanical and histological adaptations to hip pathology. PMID:29423246

Gut microbiota of liver transplantation recipients.

PubMed

Sun, Li-Ying; Yang, Yun-Sheng; Qu, Wei; Zhu, Zhi-Jun; Wei, Lin; Ye, Zhi-Sheng; Zhang, Jian-Rui; Sun, Xiao-Ye; Zeng, Zhi-Gui

2017-06-19

The characteristics of intestinal microbial communities may be affected by changes in the pathophysiology of patients with end-stage liver disease. Here, we focused on the characteristics of intestinal fecal microbial communities in post-liver transplantation (LT) patients in comparison with those in the same individuals pre-LT and in healthy individuals. The fecal microbial communities were analyzed via MiSeq-PE250 sequencing of the V4 region of 16S ribosomal RNA and were then compared between groups. We found that the gut microbiota of patients with severe liver disease who were awaiting LT was significantly different from that of healthy controls, as represented by the first principal component (p = 0.0066). Additionally, the second principal component represented a significant difference in the gut microbiota of patients between pre-LT and post-LT surgery (p = 0.03125). After LT, there was a significant decrease in the abundance of certain microbial species, such as Actinobacillus, Escherichia, and Shigella, and a significant increase in the abundance of other microbial species, such as Micromonosporaceae, Desulfobacterales, the Sarcina genus of Eubacteriaceae, and Akkermansia. Based on KEGG profiles, 15 functional modules were enriched and 21 functional modules were less represented in the post-LT samples compared with the pre-LT samples. Our study demonstrates that fecal microbial communities were significantly altered by LT.

Pre-Liver Transplant Transthoracic Echocardiogram Findings and 6-Month Post-Transplant Outcomes: A Case-Control Analysis.

PubMed

Konerman, Monica A; Price, Jennifer C; Campbell, Catherine Y; Eluri, Swathi; Gurakar, Ahmet; Hamilton, James; Li, Zhiping

2016-07-05

BACKGROUND Cardiopulmonary (CP) outcomes remain a leading cause of morbidity and mortality following liver transplantation (LT). The optimal CP risk stratification of LT candidates remains unclear. The aim of this study was to evaluate the association of pre-LT transthoracic echocardiogram (TTE) findings and 6-month post-LT outcomes. MATERIAL AND METHODS This retrospective review analyzed adults who underwent LT, comparing those who died within 6 months of LT (cases; n=38) with age- and sex-matched patients who survived >6 months (controls; n=38). Cases were categorized by cause of death (COD) defined as either a primary CP process (n=20) or a non-CP process (n=18). Data were analyzed using logistic regression and survival analysis was performed using Kaplan-Meier curves. RESULTS There was a higher odds of death within 6 months of LT with ≥ mild mitral regurgitation (OR 3.44, p=0.03) or an incomplete assessment of right ventricular systolic function (RVSF) (OR 24, p=0.004). On subgroup analysis, these findings only persisted in patients with a CP COD. Patients with CP COD were older (61 vs. 54.5, p=0.04), had longer intervals between TTE and LT (122 vs. 29 days, p=0.05), less complete assessments of RVSF (p=0.009), and lower RV fractional area change (p=0.04) compared to patients with non-CP COD. CONCLUSIONS Multiple TTE parameters were associated with patients who died within 6 months of LT, and in particular patients with a CP COD. Our findings suggest that pre-LT TTEs can convey useful CP risk stratification information and emphasizes the importance of adequately assessing these parameters prior to LT.

Treatment of hypothyroidism with levothyroxine plus liothyronine: a randomized, double-blind, crossover study.

PubMed

Kaminski, Juliana; Miasaki, Fabíola Yukiko; Paz-Filho, Gilberto; Graf, Hans; Carvalho, Gisah Amaral de

2016-01-01

To compare the effects of a unique fixed combination levothyroxine/liothyronine (LT4/LT3) therapy in patients with primary hypothyroidism. This is a randomized, double-blind, crossover study. Adults with primary hypothyroidism (n = 32, age 42.6 ± 13.3, 30 females) on stable doses of LT4 for ≥ 6 months (125 or 150 μg/day) were randomized to continue LT4 treatment (G1) or to start LT4/LT3 therapy (75/15 μg/day; G2). After 8 weeks, participants switched treatments for 8 more weeks. Thyroid function, lipid profile, plasma glucose, body weight, electrocardiogram, vital signs, and quality of life (QoL) were evaluated at weeks 0, 8 and 16. Free T4 levels were significantly lower while on LT4/LT3 (G1: 1.07 ± 0.29 vs. 1.65 ± 0.46; G2: 0.97 ± 0.26 vs. 1.63 ± 0.43 ng/dL; P < 0.001). TSH and T3 levels were not affected by type of therapy. More patients on LT4/LT3 had T3 levels above the upper limit (15% vs. 3%). The combination therapy led to an increase in heart rate, with no significant changes in electrocardiogram or arterial blood pressure. Lipid profile, body weight and QoL remained unchanged. The combination therapy yielded significantly lower free T4 levels, with no changes in TSH or T3 levels. More patients on LT4/T3 had elevated T3 levels, with no significant alterations in the evaluated outcomes. No clear clinical benefit of the studied formulation could be observed. Future trials need to evaluate different formulations and the impact of the combined therapy in select populations with genetic polymorphisms.

Medicaid Participation among Liver Transplant Candidates after the Affordable Care Act Medicaid Expansion.

PubMed

Tumin, Dmitry; Beal, Eliza W; Mumtaz, Khalid; Hayes, Don; Tobias, Joseph D; Pawlik, Timothy M; Washburn, W Kenneth; Black, Sylvester M

2017-08-01

The 2014 Medicaid expansion in participating states increased insurance coverage among people with chronic health conditions, but its implications for access to surgical care remain unclear. We investigated how Medicaid expansion influenced the insurance status of candidates for liver transplantation (LT) and transplant center payor mix. Data on LT candidates aged 18 to 64 years, in 2012 to 2013 (pre-expansion) and 2014 to 2015 (post-expansion), were obtained from the United Network for Organ Sharing registry. Change between the 2 periods in the percent of LT candidates using Medicaid was compared between expansion and nonexpansion states. Multivariable logistic regression was used to determine how Medicaid expansion influenced individual LT candidates' likelihood of using Medicaid insurance. The study included 33,017 LT candidates, of whom 29,666 had complete data for multivariable analysis. Medicaid enrollment increased by 4% after Medicaid expansion in participating states. One-quarter of the transplant centers in these states experienced ≥10% increase in the proportion of LT candidates using Medicaid insurance. Multivariable analysis confirmed that Medicaid expansion was associated with increased odds of LT candidates using Medicaid insurance (odds ratio 1.49; 95% CI 1.34, 1.66; p < 0.001). However, the absolute number and demographic characteristics of patients listed for LT did not change in Medicaid expansion states during the post-expansion period. Candidates for LT became more likely to use Medicaid after the 2014 Medicaid expansion policy came into effect. Enactment of this policy did not appear to increase access to LT or address socioeconomic and demographic disparities in access to the LT wait list. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

Circulating concentrations of free thyroxine after an oral intake of liquid LT4 taken either during fasting conditions or at breakfast.

PubMed

Marina, Michela; Ceda, Gian Paolo; Aloe, Rosalia; Gnocchi, Cecilia; Ceresini, Graziano

2017-01-16

Liquid levothyroxine (LT4) given at breakfast normalizes TSH in hypothyroid patients. However, a few studies are available on circulating free thyroxine (FT4) concentrations after liquid vs solid LT4 preparations. During an "ad interim" analysis on serum FT4 after 200 mcg liquid LT4 consumption while fasting in thyroidectomized thyroid cancer patients, we found that seven subjects fortuitously took liquid LT4 at breakfast. As established in the original protocol, serum FT4 was measured both at baseline as well as at 3 and 4 hours after solid or liquid LT4 consumption. We compared serum profile of FT4 in these subjects with those obtained in other subjects participating in the same study who took liquid LT4 (n. 7 subjects) or solid LT4 (n. 7 subjects) while fasting. The percentage increase of circulating FT4 was calculated at the above reported peak-times over the baseline values. Circulating FT4 increased of about 40% in each group of subjects at both the 3rd and the 4th hour with no difference between these two time points in either group. The maximum FT4 % increase, irrespective of the time point, was 44.62 ± 3.05 (Mean ± SE), 44.84 ± 5.43, and 43.83 ± 1.30 after fasting solid, fasting liquid, and breakfast liquid LT4 consumption, respectively, with no differences among the three groups. Circulating FT4 obtained after 3 and 4 hours from the ingestion of 200 mcg liquid LT4 is not influenced by meal and is comparable with that observed after solid LT4 preparations ingested while fasting.

Intention-to-treat survival benefit of liver transplantation in patients with hepatocellular cancer.

PubMed

Lai, Quirino; Vitale, Alessandro; Iesari, Samuele; Finkenstedt, Armin; Mennini, Gianluca; Spoletini, Gabriele; Hoppe-Lotichius, Maria; Vennarecci, Giovanni; Manzia, Tommaso M; Nicolini, Daniele; Avolio, Alfonso W; Frigo, Anna Chiara; Graziadei, Ivo; Rossi, Massimo; Tsochatzis, Emmanouil; Otto, Gerd; Ettorre, Giuseppe M; Tisone, Giuseppe; Vivarelli, Marco; Agnes, Salvatore; Cillo, Umberto; Lerut, Jan

2017-12-01

The debate about the best approach to select patients with hepatocellular cancer (HCC) waiting for liver transplantation (LT) is still ongoing. This study aims to identify the best variables allowing to discriminate between "high-" and "low-benefit" patients. To do so, the concept of intention-to-treat (ITT) survival benefit of LT has been created. Data of 2,103 adult HCC patients consecutively enlisted during the period 1987-2015 were analyzed. Three rigorous statistical steps were used in order to create the ITT survival benefit of LT: the development of an ITT LT and a non-LT survival model, and the individual prediction of the ITT survival benefit of LT defined as the difference between the median ITT survival with (based on the first model) and without LT (based on the second model) calculated for each enrolled patient. Four variables (Model for End-Stage Liver Disease, alpha-fetoprotein, Milan-Criteria status, and radiological response) displayed a high effect in terms of delta benefit. According to these risk factors, four benefit groups were identified. Patients with three to four factors ("no-benefit group"; n = 405 of 2,103; 19.2%) had no benefit of LT compared to alternative treatments. Conversely, patients without any risk factor ("large-benefit group"; n = 108; 5.1%) yielded the highest benefit from LT reaching 60 months. The ITT transplant survival benefit presented here allows physicians to better select HCC patients waiting for LT. The obtained stratification may lead to an improved and more equitable method of organ allocation. Patients without benefit should be de-listed, whereas patients with large benefit ratio should be prioritized for LT. (Hepatology 2017;66:1910-1919). © 2017 by the American Association for the Study of Liver Diseases.

 Increased hepatocellular carcinoma recurrence in women compared to men with high alpha fetoprotein at liver transplant.

PubMed

Sarkar, Monika; Dodge, Jennifer L; Roberts, John P; Terrault, Norah; Yao, Francis; Mehta, Neil

2016-01-01

 Introduction. Men have higher risk for hepatocellular carcinoma (HCC) than women. Pre liver transplant (LT) alpha fetoprotein (AFP) levels strongly predict post LT HCC recurrence. Though women with HCC have higher AFP, the contribution of AFP level by gender to post LT HCC recurrence is unknown. In this UNOSbased, retrospective cohort study we investigate sex differences in HCC recurrence among LT recipients with MELD exception between 2006-2010. Covariates include race, disease etiology, co-morbidities, AFP at listing and LT, tumor burden, loco-regional therapy, and donor risk index. HCC recurrence was assessed by competing risks regression. Of the eligible cohort (n = 5,002) included 3,872 men and 1,130 women. HCC recurred in 258 men (7%) and 66 women (6%). Median listing AFP was higher in women than men (14 vs. 11 ng/dL, p < 0.001). While no sex difference in overall HCC recurrence was detected (HR 0.9, 95% CI 0.7-1.2, p = 0.38), there was a strong interaction between gender and AFP on recurrence risk (p = 0.02). HCC recurrence was nearly three times higher in women (HR 4.2, 95% CI 2.2-8.2, p < 0.001) than men (HR 1.5, 95% CI 1.1-2.1, p = 0.02) with AFP at LT between 101-500 ng/dL. This study reveals novel sex differences in post LT HCC recurrence, which was nearly three times higher in women than men with high AFP at LT. Pre-LT AFP levels appear to carry a different prognosis in women than men, and a subset of female LT recipients may benefit from more intensive HCC surveillance after LT.

Atraumatic tears of the ligamentum teres are more frequent in professional ballet dancers than a sporting population.

PubMed

Mayes, Susan; Ferris, April-Rose; Smith, Peter; Garnham, Andrew; Cook, Jill

2016-07-01

To compare the frequency of atraumatic ligamentum teres (LT) tear in professional ballet dancers with that of athletes, and to determine the relationship with clinical and imaging findings. Forty-nine male and female professional ballet dancers (98 hips) and 49 age and sex-matched non-dancing athletes (98 hips) completed questionnaires on hip symptoms and physical activity levels, underwent hip rotation range of movement (ROM) and hypermobility testing, and 3.0-Tesla magnetic resonance imaging (3 T MRI) on both hips to detect LT tears, acetabular labral tears, and articular cartilage defects, and to measure the lateral centre edge angles (LCE). A higher frequency of LT tear was found in dancers (55 %) compared with athletes (22 %, P = 0.001). The frequency and severity of LT tears in dancers increased with older age (P = 0.004, P = 0.006, respectively). The Hip and Groin Outcome Score (HAGOS) pain scores or hip rotation ROM did not differ significantly among participants with normal, partial, or complete tears of LT (P > 0.01 for all). Neither the frequency of generalised joint hypermobility (P = 0.09) nor the LCE angles (P = 0.32, P = 0.16, left and right hips respectively) differed between those with and those without LT tear. In most hips, LT tear co-existed with either a labral tear or a cartilage defect, or both. The higher frequency of atraumatic LT tears in professional ballet dancers suggests that the LT might be abnormally loaded in ballet, and caution is required when evaluating MRI, as LT tears may be asymptomatic. A longitudinal study of this cohort is required to determine if LT tear predisposes the hip joint to osteoarthritis.

Effect of the laryngeal tube on the no-flow-time in a simulated two rescuer basic life support setting with inexperienced users.

PubMed

Schröder, J; Bucher, M; Meyer, O

2016-09-01

Intubation with a laryngeal tube (LT) is a recommended alternative to endotracheal intubation during advanced life support (ALS). LT insertion is easy; therefore, it may also be an alternative to bag-mask ventilation (BMV) for untrained personnel performing basic life support (BLS). Data from manikin studies support the influence of LT on no-flow-time (NFT) during ALS. We performed a prospective, randomized manikin study using a two-rescuer model to compare the effects of ventilation using a LT and BMV on NFT during BLS. Participants were trained in BMV and were inexperienced in the use of a LT. There was no significant difference in total NFT with the use of a LT and BMV (LT: mean 83.1 ± 37.3 s; BMV: mean 78.7 ± 24.5 s; p = 0.313), but we found significant differences in the progression of the scenario: in the BLS-scenario, the proportion of time spent performing chest compressions was higher when BMV was used compared to when a LT was used. The quality of chest compressions and the ventilation rate did not differ significantly between the two groups. The mean tidal volume and mean minute volume were significantly larger with the use of a LT compared with the use of BMV. In conclusion, in a two-rescuer BLS scenario, NFT is longer with the use of a LT (without prior training) than with the use of BMV (with prior training). The probable reasons for this result are higher tidal volumes with the use of a LT leading to longer interruptions without chest compressions.

Allelic Variation on Murine Chromosome 11 Modifies Host Inflammatory Responses and Resistance to Bacillus anthracis

PubMed Central

Terra, Jill K.; France, Bryan; Cote, Christopher K.; Jenkins, Amy; Bozue, Joel A.; Welkos, Susan L.; Bhargava, Ragini; Ho, Chi-Lee; Mehrabian, Margarete; Pan, Calvin; Lusis, Aldons J.; Davis, Richard C.; LeVine, Steven M.; Bradley, Kenneth A.

2011-01-01

Anthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced by pathogen-encoded virulence factors such as lethal toxin (LT), as well as by genetic variation within the host. To identify host genes controlling susceptibility to anthrax, a library of congenic mice consisting of strains with homozygous chromosomal segments from the LT-responsive CAST/Ei strain introgressed on a LT-resistant C57BL/6 (B6) background was screened for response to LT. Three congenic strains containing CAST/Ei regions of chromosome 11 were identified that displayed a rapid inflammatory response to LT similar to, but more severe than that driven by a LT-responsive allele of the inflammasome constituent NRLP1B. Importantly, increased response to LT in congenic mice correlated with greater resistance to infection by the Sterne strain of B. anthracis. The genomic region controlling the inflammatory response to LT was mapped to 66.36–74.67 Mb on chromosome 11, a region that encodes the LT-responsive CAST/Ei allele of Nlrp1b. However, known downstream effects of NLRP1B activation, including macrophage pyroptosis, cytokine release, and leukocyte infiltration could not fully explain the response to LT or the resistance to B. anthracis Sterne in congenic mice. Further, the exacerbated response in congenic mice is inherited in a recessive manner while the Nlrp1b-mediated response to LT is dominant. Finally, congenic mice displayed increased responsiveness in a model of sepsis compared with B6 mice. In total, these data suggest that allelic variation of one or more chromosome 11 genes in addition to Nlrp1b controls the severity of host response to multiple inflammatory stimuli and contributes to resistance to B. anthracis Sterne. Expression quantitative trait locus analysis revealed 25 genes within this region as high priority candidates for contributing to the host response to LT. PMID:22241984

The Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb and Their Respective B Pentamers Differentially Induce and Regulate Cytokine Production in Human Monocytic Cells

PubMed Central

Hajishengallis, George; Nawar, Hesham; Tapping, Richard I.; Russell, Michael W.; Connell, Terry D.

2004-01-01

The type II heat-labile enterotoxins, LT-IIa and LT-IIb, exhibit potent adjuvant properties. However, little is known about their immunomodulatory activities upon interaction with innate immune cells, unlike the widely studied type I enterotoxins that include cholera toxin (CT). We therefore investigated interactions of LT-IIa and LT-IIb with human monocytic THP-1 cells. We found that LT-II enterotoxins were inactive in stimulating cytokine release, whereas CT induced low levels of interleukin-1β (IL-1β) and IL-8. However, all three enterotoxins potently regulated cytokine induction in cells activated by bacterial lipopolysaccharide or fimbriae. Induction of proinflammatory (tumor necrosis factor α [TNF-α]) or chemotactic (IL-8) cytokines was downregulated, whereas induction of cytokines with anti-inflammatory (IL-10) or mucosal adjuvant properties (IL-1β) was upregulated by the enterotoxins. These effects appeared to depend on their A subunits, because isolated B-pentameric subunits lacked regulatory activity. Enterotoxin-mediated inhibition of proinflammatory cytokine induction in activated cells was partially attributable to synergism for endogenous production of IL-10 and to an IL-10-independent inhibition of nuclear factor κB (NF-κB) activation. In sharp contrast to the holotoxins, the B pentamers (LT-IIaB and, to a greater extent, LT-IIbB) stimulated cytokine production, suggesting a link between the absence of the A subunit and increased proinflammatory properties. In this regard, the ability of LT-IIbB to activate NF-κB and induce TNF-α and IL-8 was antagonized by the LT-IIb holotoxin. These findings support distinct immunomodulatory roles for the LT-II holotoxins and their respective B pentamers. Moreover, the anti-inflammatory properties of the holotoxins may serve to suppress innate immunity and promote the survival of the pathogen. PMID:15501764

Changes in transverse relaxation time of quadriceps femoris muscles after active recovery exercises with different intensities.

PubMed

Mukaimoto, Takahiro; Semba, Syun; Inoue, Yosuke; Ohno, Makoto

2014-01-01

The purpose of this study was to examine the changes in the metabolic state of quadriceps femoris muscles using transverse relaxation time (T2), measured by muscle functional magnetic resonance (MR) imaging, after inactive or active recovery exercises with different intensities following high-intensity knee-extension exercise. Eight healthy men performed recovery sessions with four different conditions for 20 min after high-intensity knee-extension exercise on separate days. During the recovery session, the participants conducted a light cycle exercise for 20 min using a cycle (50%, 70% and 100% of the lactate threshold (LT), respectively: active recovery), and inactive recovery. The MR images of quadriceps femoris muscles were taken before the trial and after the recovery session every 30 min for 120 min. The percentage changes in T2 for the rectus femoris and vastus medialis muscles after the recovery session in 50% LT and 70% LT were significantly lower than those in either inactive recovery or 100% LT. There were no significant differences in those for vastus lateralis and vastus intermedius muscles among the four trials. The percentage changes in T2 of rectus femoris and vastus medialis muscles after the recovery session in 50% LT and 70% LT decreased to the values before the trial faster than those in either inactive recovery or 100% LT. Those of vastus lateralis and vastus intermedius muscles after the recovery session in 50% LT and 70% LT decreased to the values before the trial faster than those in 100% LT. Although the changes in T2 after active recovery exercises were not uniform in exercised muscles, the results of this study suggest that active recovery exercise with the intensities below LT are more effective to recover the metabolic state of quadriceps femoris muscles after intense exercise than with either intensity at LT or inactive recovery.

Binding to Gangliosides Containing N-Acetylneuraminic Acid Is Sufficient To Mediate the Immunomodulatory Properties of the Nontoxic Mucosal Adjuvant LT-IIb(T13I) ▿

PubMed Central

Nawar, Hesham F.; Berenson, Charles S.; Hajishengallis, George; Takematsu, Hiromu; Mandell, Lorrie; Clare, Ragina L.; Connell, Terry D.

2010-01-01

By use of a mouse mucosal immunization model, LT-IIb(T13I), a nontoxic mutant type II heat-labile enterotoxin, was shown to have potent mucosal and systemic adjuvant properties. In contrast to LT-IIb, which binds strongly to ganglioside receptors decorated with either N-acetylneuraminic acid (NeuAc) or N-glycolylneuraminic acid (NeuGc), LT-IIb(T13I) binds NeuAc gangliosides much less well. Rather, LT-IIb(T13I) binds preferentially to NeuGc gangliosides. To determine if the adjuvant properties of LT-IIb(T13I) are altered in the absence of NeuGc ganglioside receptors, experiments were conducted using a Cmah-null mouse line which is deficient in the synthesis of NeuGc gangliosides. Several immunomodulatory properties of LT-IIb(T13I) were shown to be dependent on NeuGc gangliosides. LT-IIb(T13I) had reduced binding activity for NeuGc-deficient B cells and macrophages; binding to NeuGc-deficient T cells and dendritic cells (DC) was essentially undetectable. Treatment of Cmah-null macrophages with LT-IIb(T13I), however, upregulated the transcription of interleukin-4 (IL-4), IL-6, IL-17, and gamma interferon (IFN-γ), four cytokines important for promoting immune responses. The production of mucosal IgA and serum IgG against an immunizing antigen was augmented in NeuGc-deficient mice administered LT-IIb(T13I) as a mucosal adjuvant. Notably, NeuGc gangliosides are not expressed in humans. Still, treatment of human monocytes with LT-IIb(T13I) induced the secretion of IL-6, an inflammatory cytokine that mediates differential control of leukocyte activation. These results suggested that NeuAc gangliosides are sufficient to mediate the immunomodulatory properties of LT-IIb(T13I) in mice and in human cells. The nontoxic mutant enterotoxin LT-IIb(T13I), therefore, is potentially a new and safe human mucosal adjuvant. PMID:20392887

Isolation and Characterization of Viruses from the Kidneys of Rana pipiens with Renal Adenocarcinoma Before and After Passage in the Red Eft (Triturus viridescens)

PubMed Central

Clark, H. Fred; Brennan, James C.; Zeigel, Robert F.; Karzon, David T.

1968-01-01

Viruses were isolated from kidneys of normal and renal tumor-bearing Vermont Rana pipiens after subinoculation into red eft newts (Triturus viridescens). Organs of efts inoculated with viable cell suspensions from four of seven tumor-bearing kidneys yielded virus (LT-1, -2, -3, -4) when inoculated into TH-1 (Terrapene heart) cell culture. One tumor-bearing kidney also yielded virus (L-4) by direct inoculation into TH-1 cells. An additional isolate (L-5) was obtained from 1 of 52 normal Vermont frog kidneys inoculated directly into TH-1 cells. LT-1 was propagated with cytopathic effect (CPE) in each of 38 cell types tested, of fish, amphibian, reptilian, avian, and mammalian origin, at 23 or 30 C. LT-1 through LT-4, L-4 and L-5, and FV-1 through FV-3 each induced similar CPE in all cells tested. LT-2, however, induced CPE that progressed at a slower rate than that caused by the other isolates and produced smaller plaques (<0.8 mm) under starch gel overlay. Each of the viruses replicated to high titer in embryonated eggs incubated at 30 C. The viruses also grew in efts and adult newts, but not in bullfrog (Rana catesbeiana) tadpoles or adult leopard frogs. Tumor induction in adult leopard frogs inoculated with LT-1 was not demonstrated. Electron microscopic observations of LT-1 and LT-2 viruses revealed cytoplasmic particles, hexagonal in cross section, approximately 120 to 140 mμ in diameter, containing a dense nucleoid. LT-1 and LT-2 viruses were indistinguishable from FV-1 and Tipula iridescent virus. LT-1 was presumed to be a deoxyribonucleic acid virus on the basis of 5-bromodeoxyuridine inhibition. The isolates were ether-sensitive. On the basis of biological, physicochemical, and antigenic similarities, LT-1 through LT-4, L-4, L-5, FV-1 through FV-3, and isolates recently recovered from the bullfrog and the newt may represent strains of the same amphibian cytoplasmic virus. Images PMID:4972302

Evidence for Moho-lower crustal transition depth diking and rifting of the Sierra Nevada microplate

NASA Astrophysics Data System (ADS)

Smith, Kenneth D.; Kent, Graham M.; Seggern, David P.; Driscoll, Neal W.; Eisses, Amy

2016-10-01

Lithospheric rifting most often initiates in continental extensional settings where "breaking of a plate" may or may not progress to sea floor spreading. Generally, the strength of the lithosphere is greater than the tectonic forces required for rupture (i.e., the "tectonic force paradox"), and it has been proposed that rifting requires basaltic magmatism (e.g., dike emplacement) to reduce the strength and cause failure, except for the case of a thin lithosphere (<30 km thick). Here we isolate two very similar and unprecedented observations of Moho-lower crustal transition dike or fluid injection earthquake swarms under southern Sierra Valley (SV: 2011-2012) and North Lake Tahoe (LT: 2003-2004), California. These planar distributions of seismicity can be interpreted to define the end points, and cover 25% of the length, of an implied 56 km long structure, each striking N45°W and dipping 50°NE. A single event at 30 km depth that locates on the implied dipping feature between the two swarms is further evidence for a single Moho-transition depth structure. We propose that basaltic or fluid emplacement at or near Moho depths weakens the upper mantle lid, facilitating lithospheric rupture of the Sierra Microplate. Similar to the LT sequence, the SV event is also associated with increased upper crustal seismicity. An 27 October 2011, Mw 4.7 earthquake occurred directly above the deep SV sequence at the base of the upper crustal seismogenic zone ( 15 km depth).

Strategy for eliciting antigen-specific CD8+ T cell-mediated immune response against a cryptic CTL epitope of merkel cell polyomavirus large T antigen

PubMed Central

2012-01-01

Background Merkel cell carcinoma (MCC) is a relatively new addition to the expanding category of oncovirus-induced cancers. Although still comparably rare, the number of cases has risen dramatically in recent years. Further complicating this trend is that MCC is an extremely aggressive neoplasm with poor patient prognosis and limited treatment options for advanced disease. The causative agent of MCC has been identified as the merkel cell polyomavirus (MCPyV). The MCPyV-encoded large T (LT) antigen is an oncoprotein that is theorized to be essential for virus-mediated tumorigenesis and is therefore, an excellent MCC antigen for the generation of antitumor immune responses. As a foreign antigen, the LT oncoprotein avoids the obstacle of immune tolerance, which normally impedes the development of antitumor immunity. Ergo, it is an excellent target for anti-MCC immunotherapy. Since tumor-specific CD8+ T cells lead to better prognosis for MCC and numerous other cancers, we have generated a DNA vaccine that is capable of eliciting LT-specific CD8+ T cells. The DNA vaccine (pcDNA3-CRT/LT) encodes the LT antigen linked to a damage-associated molecular pattern, calreticulin (CRT), as it has been demonstrated that the linkage of CRT to antigens promotes the induction of antigen-specific CD8+ T cells. Results The present study shows that DNA vaccine-induced generation of LT-specific CD8+ T cells is augmented by linking CRT to the LT antigen. This is relevant since the therapeutic effects of the pcDNA3-CRT/LT DNA vaccine is mediated by LT-specific CD8+ T cells. Mice vaccinated with the DNA vaccine produced demonstrably more LT-specific CD8+ T cells. The DNA vaccine was also able to confer LT-specific CD8+ T cell-mediated protective and therapeutic effects to prolong the survival of mice with LT-expressing tumors. In the interest of determining the LT epitope which most MCC-specific CD8+ T cells recognize, we identified the amino acid sequence of the immunodominant LT epitope as aa19-27 (IAPNCYGNI) and found that it is H-2kb-restricted. Conclusion The results of this study can facilitate the development of other modes of MCC treatment such as peptide-based vaccines and adoptive transfer of LT-specific CD8+ T cells. Likewise, the MCC DNA vaccine has great potential for clinical translation as the immunologic specificity is high and the treatment strategy can be exported to address other virus-induced tumors. PMID:23095249

Structure–activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cody, Vivian, E-mail: cody@hwi.buffalo.edu; University at Buffalo, 700 Ellicott Street, Buffalo, NY 14203; Pace, Jim

2012-12-01

Structural data for the S74D variant of the pentameric B subunit of type II heat-labile enterotoxin of Escherichia coli reveal a smaller pore opening that may explain its reduced Toll-like receptor binding affinity compared to that of the wild type enterotoxin. The explanation for the enhanced Toll-like receptor binding affinity of the S74A variant is more complex than simply being attributed to the pore opening. The pentameric B subunit of the type II heat-labile enterotoxin of Escherichia coli (LT-IIb-B{sub 5}) is a potent signaling molecule capable of modulating innate immune responses. It has previously been shown that LT-IIb-B{sub 5}, butmore » not the LT-IIb-B{sub 5} Ser74Asp variant [LT-IIb-B{sub 5}(S74D)], activates Toll-like receptor (TLR2) signaling in macrophages. Consistent with this, the LT-IIb-B{sub 5}(S74D) variant failed to bind TLR2, in contrast to LT-IIb-B{sub 5} and the LT-IIb-B{sub 5} Thr13Ile [LT-IIb-B{sub 5}(T13I)] and LT-IIb-B{sub 5} Ser74Ala [LT-IIb-B{sub 5}(S74A)] variants, which displayed the highest binding activity to TLR2. Crystal structures of the Ser74Asp, Ser74Ala and Thr13Ile variants of LT-IIb-B{sub 5} have been determined to 1.90, 1.40 and 1.90 Å resolution, respectively. The structural data for the Ser74Asp variant reveal that the carboxylate side chain points into the pore, thereby reducing the pore size compared with that of the wild-type or the Ser74Ala variant B pentamer. On the basis of these crystallographic data, the reduced TLR2-binding affinity of the LT-IIb-B{sub 5}(S74D) variant may be the result of the pore of the pentamer being closed. On the other hand, the explanation for the enhanced TLR2-binding activity of the LT-IIb-B{sub 5}(S74A) variant is more complex as its activity is greater than that of the wild-type B pentamer, which also has an open pore as the Ser74 side chain points away from the pore opening. Data for the LT-IIb-B{sub 5}(T13I) variant show that four of the five variant side chains point to the outside surface of the pentamer and one residue points inside. These data are consistent with the lack of binding of the LT-IIb-B{sub 5}(T13I) variant to GD1a ganglioside.« less

Forecasting Ionospheric Real-time Scintillation Tool (FIRST)

NASA Astrophysics Data System (ADS)

Anderson, D. N.; Redmon, R.; Bullett, T.; Caton, R. G.; Retterer, J. M.

2009-05-01

It is well-known that the generation of equatorial, F-region plasma density irregularities, via the Generalized Rayleigh-Taylor instability mechanism is critically dependent on the magnitude of the pre-reversal enhancement (PRE) in upward ExB drift velocity after sunset. These plasma density bubbles that are generated after sunset lead to the scintillation of trans-ionospheric radio wave signals that pass through these bubbles and is commonly referred to as scintillation activity. Communication and Navigation systems can be severely disrupted by these plasma density irregularities. A measure of scintillation activity is given by the S4 Index and a network of Air Force, ground-based UHF and L-band receivers measuring the S4 Index is called the SCIntillation Network Decision Aid (SCINDA) network. After sunset, the height-rise with time of the bottom- side of the F-layer reflects the magnitude of the upward ExB drift velocity. The value of the ionospheric parameter, h'F (the virtual height of the bottom-side F-layer) at 1930 LT reflects the integrated ExB drift effect on lifting the F-layer to an altitude where the Rayleigh-Taylor (R-T) instability mechanism becomes important. It is found that there exists a threshold in the h'F value at 1930 LT and the onset of scintillation activity as measured by the S4 Index value in the Peruvian longitude sector. This h'F threshold value is found to decrease with decreasing F10.7 cm fluxes in a linear manner (R = 0.99). T o examine this relationship, theoretically, we incorporate a suite of first-principle models of the ambient ionosphere (PBMOD) developed at the Air Force Research Lab (AFRL) to investigate R-T growth rates and threshold h'F (1930 LT) values as a function of solar cycle activity. In addition, this paper describes a technique for automatically forecasting, in real-time, the occurrence or non-occurrence of scintillation activity that relies on real-time data from a ground-based ionospheric sounder at or near the geomagnetic equator. We describe how FIRST has been developed into a real-time capability for automatically forecasting scintillation activity that is available on Google Earth to all interested parties.

The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA

PubMed Central

Gai, Dahai; Wang, Damian; Li, Shu-Xing; Chen, Xiaojiang S

2016-01-01

DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin. How these hexameric helicases interact with their origin dsDNA remains unknown. Here, we report the co-crystal structure of the SV40 Large-T Antigen (LT) hexameric helicase bound to its origin dsDNA. The structure shows that the six subunits form a near-planar ring that interacts with the origin, so that each subunit makes unique contacts with the DNA. The origin dsDNA inside the narrower AAA+ domain channel shows partial melting due to the compression of the two phosphate backbones, forcing Watson-Crick base-pairs within the duplex to flip outward. This structure provides the first snapshot of a hexameric helicase binding to origin dsDNA, and suggests a possible mechanism of origin melting by LT during SV40 replication in eukaryotic cells. DOI: http://dx.doi.org/10.7554/eLife.18129.001 PMID:27921994

Late HIV Testing in a Cohort of HIV-Infected Patients in Puerto Rico.

PubMed

Tossas-Milligan, Katherine Y; Hunter-Mellado, Robert F; Mayor, Angel M; Fernández-Santos, Diana M; Dworkin, Mark S

2015-09-01

Late HIV testing (LT), defined as receiving an AIDS diagnosis within a year of one's first positive HIV test, is associated with higher HIV transmission, lower HAART effectiveness, and worse outcomes. Latinos represent 36% of LT in the US, yet research concerning LT among HIV cases in Puerto Rico is scarce. Multivariable logistic regression analysis was used to identify factors associated with LT, and a Cochran‒Armitage test was used to determine LT trends in an HIV-infected cohort followed at a clinic in Puerto Rico specialized in the management and treatment of HIV. From 2000 to 2011, 47% of eligible patients were late testers, with lower median CD4 counts (54 vs. 420 cells/mm3) and higher median HIV viral load counts (253,680 vs. 23,700 copies/mL) than non-LT patients. LT prevalence decreased significantly, from 47% in 2000 to 37% in 2011. In a mutually adjusted logistic regression model, males, older age at enrollment and past history of IDU significantly increased LT odds, whereas having a history of amphetamine use decreased LT odds. When the data were stratified by mode of transmission, it became apparent that only the category men who have sex with men (MSM) saw a significant reduction in the proportion of LT, falling from 67% in 2000 to 33% in 2011. These results suggest a gap in early HIV detection in Puerto Rico, a gap that decreased only among MSM. An evaluation of the manner in which current HIV-testing guidelines are implemented on the island is needed.

Clinical Outcomes of Lung Transplantation in Patients with Telomerase Mutations

PubMed Central

Tokman, Sofya; Singer, Jonathan P.; Devine, Megan S.; Westall, Glen P.; Aubert, John-David; Tamm, Michael; Snell, Gregory I.; Lee, Joyce S.; Goldberg, Hilary J.; Kukreja, Jasleen; Golden, Jeffrey A.; Leard, Lorriana E.; Garcia, Christine K.; Hays, Steven R.

2017-01-01

Background Successful lung transplantation (LT) for patients with pulmonary fibrosis from telomerase mutations is limited by systemic complications of telomerase dysfunction including myelosuppression, cirrhosis, and malignancy. We describe clinical outcomes among 14 LT recipients with telomerase mutations. Methods Subjects underwent LT between February 2005 and April 2014 at 5 LT centers. We abstracted data from medical records, focusing on outcomes reflecting post-LT treatment effects likely to be complicated by telomerase mutations. Results The median age of subjects was 60.5 years (IQR 52.0–62.0), 64.3% were male, and the mean post-LT observation time was 3.2 years (SD ±2.9). Eleven subjects had a mutation in telomerase reverse transcriptase, 2 in telomerase RNA component, and 1 had an uncharacterized mutation. Ten subjects were leukopenic post-LT; leukopenia prompted cessation of mycophenolate mofetil in 5 and treatment with filgrastim in 4. Six subjects had recurrent lower respiratory tract infections (LRTI), 7 had acute cellular rejection (ACR) (A1), and 4 developed chronic lung allograft dysfunction (CLAD). Ten LT recipients developed chronic renal insufficiency and 8 experienced acute, reversible renal failure. Three developed cancer, none had cirrhosis. Thirteen subjects were alive at data censorship. Conclusions The clinical course for LT recipients with telomerase mutations is complicated by renal disease, leukopenia prompting a change in the immunosuppressive regimen, and recurrent LTRI. In contrast, cirrhosis was absent, ACR was mild, and development of CLAD was comparable to other LT populations. While posing challenges, lung transplantation may be feasible for patients with pulmonary fibrosis due to telomerase mutations. PMID:26169663

Liquiritin (LT) exhibits suppressive effects against the growth of human cervical cancer cells through activating Caspase-3 in vitro and xenograft mice in vivo.

PubMed

He, She-Hong; Liu, Hong-Gai; Zhou, Yu-Fei; Yue, Qing-Fen

2017-08-01

Cervical cancer is one of the most common female malignancies worldwide. Liquiritin (LT), a major constituent of Glycyrrhiza Radix, possesses a variety of pharmacological activities, including anti-cancer, anti-oxidative, anti-inflammatory and neuro-protective effects. However, its role in human cervical cancer remains to be elusive. In our study, we found that LT suppressed cervical cancer cell migration, invasion and cloning ability with little cytotoxicity to human normal cells. In addition, apoptosis was induced by LT in cervical cancer cells through activation of Caspase-3 and poly ADP-ribose polymerase (PARP) cleavage. LT-triggered apoptosis was dependent on extrinsic and intrinsic pathways, which were relied on Fas-associated protein with death domain (FADD)- and Bcl-2/Bax-regulated pathways, leading to Caspase-8 and Caspase-9 cleavage, respectively. LT was found to increase FADD expression, while reduce Bcl-2 expression, contributing to Caspase-3 cleavage. And tumor suppressors, p21 and p53, were enhanced after LT treatment, inhibiting the growth of cervical cancer cells in vitro. Significantly, in vivo study suggested that tumor growth was impeded by LT in a dose-dependent manner through enhancing apoptosis. Together, the data here revealed that LT was an effective and promising candidate for preventing human cervical cancer progression via apoptosis enhancement. Copyright © 2017. Published by Elsevier Masson SAS.

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.

PubMed

Newman, Zachary L; Printz, Morton P; Liu, Shihui; Crown, Devorah; Breen, Laura; Miller-Randolph, Sharmina; Flodman, Pamela; Leppla, Stephen H; Moayeri, Mahtab

2010-05-20

Anthrax lethal toxin (LT) is a bipartite protease-containing toxin and a key virulence determinant of Bacillus anthracis. In mice, LT causes the rapid lysis of macrophages isolated from certain inbred strains, but the correlation between murine macrophage sensitivity and mouse strain susceptibility to toxin challenge is poor. In rats, LT induces a rapid death in as little as 37 minutes through unknown mechanisms. We used a recombinant inbred (RI) rat panel of 19 strains generated from LT-sensitive and LT-resistant progenitors to map LT sensitivity in rats to a locus on chromosome 10 that includes the inflammasome NOD-like receptor (NLR) sensor, Nlrp1. This gene is the closest rat homolog of mouse Nlrp1b, which was previously shown to control murine macrophage sensitivity to LT. An absolute correlation between in vitro macrophage sensitivity to LT-induced lysis and animal susceptibility to the toxin was found for the 19 RI strains and 12 additional rat strains. Sequencing Nlrp1 from these strains identified five polymorphic alleles. Polymorphisms within the N-terminal 100 amino acids of the Nlrp1 protein were perfectly correlated with LT sensitivity. These data suggest that toxin-mediated lethality in rats as well as macrophage sensitivity in this animal model are controlled by a single locus on chromosome 10 that is likely to be the inflammasome NLR sensor, Nlrp1.

Less aggressive disease in patients with primary squamous cell carcinomas of the thyroid gland and coexisting lymphocytic thyroiditis.

PubMed

Asik, Mehmet; Binnetoglu, Emine; Sen, Hacer; Gunes, Fahri; Muratli, Asli; Kankaya, Duygu; Uysal, Fatma; Sahin, Mustafa; Ukinc, Kubilay

2015-01-01

Primary squamous cell carcinoma (SCC) of the thyroid gland is extremely rare. Infrequently, primary SCC of the thyroid gland is accompanied by other thyroid diseases such as Hashimoto's thyroiditis (HT). Recently, studies have demonstrated that differentiated thyroid cancer with coexisting HT has a better prognosis. However, the prognosis of patients with primary SCC of the thyroid gland and coexistent HT has not been clearly identified. We compared the clinical characteristics and disease stages of patients with primary SCC with and without lymphocytic thyroiditis (LT). We reviewed reports of primary SCC of the thyroid gland published in the English literature. We identified 46 papers that included 17 cases of primary SCC of the thyroid gland with LT and 77 cases of primary SCC of the thyroid gland without LT. Lymph node metastasis and local invasion rates did not differ between these two groups. Distant metastases were absent in patients with LT, and were observed in 13 (16.9%) patients without LT. A greater proportion of patients without LT had advanced stage disease (stage IV A-B-C) than patients with LT (p < 0.05). Patients with primary SCC of the thyroid gland and coexisting LT had lower tumour-node-metastasis stage and frequency of distant metastasis than those without LT. Lymphocytic infiltration in patients with SCC appears to limit tumour growth and distant metastases.

Self-management and self-efficacy status in liver recipients.

PubMed

Xing, Lei; Chen, Qin-Yun; Li, Jia-Ning; Hu, Zhi-Qiu; Zhang, Ye; Tao, Ran

2015-06-01

Liver transplantation (LT) is a viable treatment for patients with end-stage chronic liver diseases. The main aim of LT is to prolong life and improve life quality. However, although survival after LT continues to improve, some aspects of recipient's health-related quality of life such as self-management and self-efficacy have been largely ignored. A total of 124 LT recipients were included in this study. Questionnaires for general health status information and a "Self-Management Questionnaire for Liver Transplantation Recipients" modified from the Chinese version of "Chronic Disease Self-Management Program Questionnaire Code Book" were used in the survey. Data were collected by self-administered questionnaires. The overall status of self-management in LT recipients was not optimistic. The major variables affecting the self-management of LT recipients were marital status, educational level and employment. The overall status of self-efficacy in LT recipients was around the medium-level. Postoperative time and self-assessment of overall health status were found as the factors impacting on self-efficacy. The self-management behavior of LT recipients needs to be improved. The health care professionals need to offer targeted health education to individual patients, help them to establish healthy lifestyle, enhance physical activity and improve self-efficacy. The development of the multilevel and multifaceted social support system will greatly facilitate the self-management in LT patients.

Advancements in the treatment of hypothyroidism with L-T4 liquid formulation or soft gel capsule: an update.

PubMed

Fallahi, Poupak; Ferrari, Silvia Martina; Ruffilli, Ilaria; Ragusa, Francesca; Biricotti, Marco; Materazzi, Gabriele; Miccoli, Paolo; Antonelli, Alessandro

2017-05-01

The most recent advance concerning levothyroxine (L-T4) therapy is the development of novel oral formulations: the liquid preparation, and the soft gel capsule. Areas covered: This review evaluates the most recent clinical studies about these new formulations. The liquid formulation has been shown to overcome: the food and beverages intereference with L-T4 tablets absorption, caused by food or coffee at breakfast; malabsorption induced by the increased gastric pH, resulting from atrophic gastritis, or due to proton-pump inhibitors; and malabsorption after bariatric surgery. The use of liquid L-T4 has been studied also in pregnancy, newborns and infants, suggesting a better bioequivalence than tablets. Finally, liquid L-T4 is more active than tablets in the control of thyroid-stimulating hormone (TSH) in hypothyroid patients without malabsorption, drug interference, or gastric disorders, leading to a hypothesized higher absorption of liquid L-T4 also in these patients. Few studies have evaluated soft gel L-T4 with promising results in patients with malabsorption related to coffee or gastritis. Expert opinion: Liquid L-T4 (and soft gel capsules) are more active than the tablet L-T4 in the control of TSH in hypothyroid patients with gastric disorders, malabsorption, or drug interference, but also in patients without absorption disorders.

Patients with high serum substance P levels previously to liver transplantation for hepatocellular carcinoma have higher risk of one-year liver transplantation mortality.

PubMed

Lorente, Leonardo; Rodriguez, Sergio T; Sanz, Pablo; Pérez-Cejas, Antonia; Padilla, Javier; Díaz, Dácil; González, Antonio; Martín, María M; Jiménez, Alejandro; Cerro, Purificación; Barrera, Manuel A

2018-04-20

Substance P is a tachykinins family member with inflammatory effects. Higher circulating levels of substance P have been found in patients with liver diseases and in patients with higher severity of liver diseases. The objective of this study was to determine whether serum levels of substance P levels, prior to liver transplantation (LT) for hepatocellular carcinoma (HCC) are associated with one-year LT mortality. In this observational retrospective unicenter study were included patients with LT for HCC. Serum levels of substance P were measured before LT. The end-point of the study was one-year mortality after LT. We found that one-year survivor patients ( n = 127) showed a lower age in liver donors ( p = 0.03) and lower levels of serum substance P levels ( p = 0.003) than non-survivor patients ( n = 15). Logistic regression analysis showed that serum levels of substance P (levels) were associated with one-year mortality (Odds Ratio = 1.011; 95% CI = 1.004-1.018; p = 0.002) controlling for the age of the LT donor. We believe that our study is the first study reporting data on circulating levels of substance P previously to LT for HCC, and an association between elevated levels of serum substance P before LT and mortality during the first year of LT.

Patients with high serum substance P levels previously to liver transplantation for hepatocellular carcinoma have higher risk of one-year liver transplantation mortality

PubMed Central

Lorente, Leonardo; Rodriguez, Sergio T.; Sanz, Pablo; Pérez-Cejas, Antonia; Padilla, Javier; Díaz, Dácil; González, Antonio; Martín, María M.; Jiménez, Alejandro; Cerro, Purificación; Barrera, Manuel A.

2018-01-01

Purpose Substance P is a tachykinins family member with inflammatory effects. Higher circulating levels of substance P have been found in patients with liver diseases and in patients with higher severity of liver diseases. The objective of this study was to determine whether serum levels of substance P levels, prior to liver transplantation (LT) for hepatocellular carcinoma (HCC) are associated with one-year LT mortality. Material and Methods In this observational retrospective unicenter study were included patients with LT for HCC. Serum levels of substance P were measured before LT. The end-point of the study was one-year mortality after LT. Results We found that one-year survivor patients (n = 127) showed a lower age in liver donors (p = 0.03) and lower levels of serum substance P levels (p = 0.003) than non-survivor patients (n = 15). Logistic regression analysis showed that serum levels of substance P (levels) were associated with one-year mortality (Odds Ratio = 1.011; 95% CI = 1.004–1.018; p = 0.002) controlling for the age of the LT donor. Conclusions We believe that our study is the first study reporting data on circulating levels of substance P previously to LT for HCC, and an association between elevated levels of serum substance P before LT and mortality during the first year of LT. PMID:29765559

Accepting multiple simultaneous liver offers does not negatively impact transplant outcomes.

PubMed

Eldeen, Firas Zahr; Mourad, Moustafa Mabrouk; Bhandari, Mayank; Roll, Garrett; Gunson, Bridget; Mergental, Hynek; Bramhall, Simon; Isaac, John; Muiesan, Paolo; Mirza, Darius F; Perera, M Thamara P R

2016-02-01

Impact of performing multiple liver transplants (LT) in a short period of time is unknown. Consecutively performed LT potentially increase complication rates through team fatigue and overutilization of resources and increase ischemia time. We analyzed the impact of undertaking consecutive LT (Consecutive liver transplant, CLT; LT preceded by another transplant performed not more than 12 h before, both transplants grouped together) on outcomes. Of 1702 LT performed, 314 (18.4%) were CLT. Outcome data was compared with solitary LT (SLT; not more than one LT in 12-h period). Recipient, donor, and graft characteristics were evenly matched between SLT and CLT; second LT of CLT group utilized younger donors grafts with longer cold ischemic times (P = 0.015). Implantation and operative time were significantly lower in CLT recipients on intergroup analysis (P = 0.0001 and 0.002, respectively). Early hepatic artery thrombosis (E-HAT) was higher in CLT versus SLT (P = 0.038), despite absolute number of E-HAT being low in all groups. Intragroup analysis demonstrated a trend toward more frequent E-HAT in first LT, compared to subsequent transplants; however, difference did not reach statistical significance (P = 0.135). In era of organ scarcity, CLT performed at high-volume center is safe and allows pragmatic utilization of organs, potentially reducing number of discarded grafts and reducing waiting list mortality. © 2015 Steunstichting ESOT.

Yoking Unequal Oxen: Organizing Forces for Dissimilar Missions

DTIC Science & Technology

2012-06-01

with Change 1 20 March 2009, I-15, V-2. 2 Michael S. Neiberg, Warfare in World History (New York: Routledge, 2001), 10-11. 3 Lynn White, Jr ., Medieval...need a greater ability to deal with guerrilla 5 Andrew F. Krepinevich, Jr ., The Army and...to show the administration the Army was taking action. The Army established the Special Warfare Directorate and placed Brig Gen William B. Rosson

Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma

PubMed Central

Lorente, Leonardo; Rodriguez, Sergio T.; Sanz, Pablo; Abreu-González, Pedro; Díaz, Dácil; Moreno, Antonia M.; Borja, Elisa; Martín, María M.; Jiménez, Alejandro; Barrera, Manuel A.

2016-01-01

Previous studies have found higher levels of serum malondialdehyde (MDA) in hepatocellular carcinoma (HCC) patients compared to healthy controls and higher MDA concentrations in tumoral tissue of HCC patients than in non-tumoral tissue. However, the association between pre-transplant serum levels of MDA and survival in HCC patients after liver transplantation (LT) has not been described, and the aim of the present study was to determine whether such an association exists. In this observational study we measured serum MDA levels in 127 patients before LT. We found higher pre-LT serum MDA levels in 15 non-surviving than in 112 surviving patients one year after LT (p = 0.02). Exact binary logistic regression analysis revealed that pre-LT serum levels of MDA over 3.37 nmol/mL were associated with mortality after one year of LT (Odds ratio = 5.38; 95% confidence interval (CI) = from 1.580 to infinite; p = 0.007) adjusting for age of the deceased donor. The main finding of our study was that there is an association between serum MDA levels before LT for HCC and 1-year survival after LT. PMID:27058525

A Seven-Year Longitudinal Claim Analysis to Assess the Factors Contributing to the Increased Severity of Work-Related Injuries.

PubMed

Kalia, Nimisha; Lavin, Robert A; Yuspeh, Larry; Bernacki, Edward J; Tao, Xuguang Grant

2016-09-01

In recent decades, the frequency of Medical Only (MO) and Lost Time (LT) workers' compensation claims has decreased, while average severity (medical and indemnity costs) has increased. The aim of this study was to compare claim frequency, mix, and severity (cost) over two periods using a claim cohort follow-up method. Sixty-two thousand five hundred thirty-three claims during two periods (1999 to 2002 and 2003 to 2006) were followed seven years postinjury. Descriptive analysis and significant testing methods were used to compare claim frequency and costs. The number of claims per $1 M of premium decreased 50.4% for MO claims and 35.6% for LT claims, consequently increasing the LT claim proportion. The average cost of LT claims did not increase. The severity increase is attributable to the proportional change in LT and MO claims. While the number of LT claims decreased, the inflation-adjusted average cost of LT claims did not increase.

Evaluation of glycerol, a biodiesel coproduct, in grow-finish pig diets to support growth and pork quality.

PubMed

Schieck, S J; Shurson, G C; Kerr, B J; Johnston, L J

2010-12-01

Crossbred pigs (n = 216; BW = 31.3 ± 1.8 kg) were used to determine the effects of long- and short-term feeding of crude glycerol on growth performance, carcass traits, and pork quality of grow-finish pigs. Pigs were blocked by initial BW, and pens within blocks were assigned randomly to 1 of 3 dietary treatments (24 pens; 9 pigs/pen). Dietary treatments were control, a corn-soybean meal-based diet (CON); long-term, CON + 8% glycerol fed throughout the experiment (LT); and short-term, pigs fed CON for the first 6 wk followed by CON + 8% glycerol fed during the last 8 wk of the experiment (ShT). Pigs fed LT had greater (P < 0.05) ADG, whereas pigs fed ShT tended (P < 0.10) to grow faster than CON (CON = 0.962 kg/d, LT = 0.996 kg/d, and ShT = 0.992 kg/d; SE = 0.01). Pigs assigned to LT had greater (P < 0.05) ADFI compared with CON, whereas ShT-fed pigs had similar ADFI to CON (CON = 2.78 kg/d, LT = 2.93 kg/d, and ShT = 2.86 kg/d; SE = 0.03). Gain:feed tended (P < 0.10) to be greater for CON- and ShT-fed pigs compared with LT-fed pigs (CON = 0.346, LT = 0.339, and ShT = 0.346; SE = 0.002). Hot carcass weight was greater (P < 0.05) for LT-fed pigs compared with CON, whereas ShT-fed pigs had HCW similar to both LT- and CON-fed pigs (CON = 94.8 kg, LT = 97.5 kg, and ShT = 96.3 kg; SE = 0.90). Dressing percentage of CON-fed pigs was similar to both LT- and ShT-fed pigs, but LT-fed pigs tended to have greater (P = 0.06) dressing percentage than ShT-fed pigs (CON = 74.5%, LT = 74.9%, and ShT = 74.3%; SE = 0.16). Tenth-rib backfat (P = 0.26) and LM area (P = 0.17) were not affected by dietary treatment. There was a trend (P < 0.10) for LT-fed pigs to have a smaller fat-free lean percentage than CON-fed pigs (CON = 53.1%, LT = 52.26%, and ShT = 52.67%; SE = 0.25). Short-term glycerol feeding increased (P < 0.05) belly firmness compared with CON and had similar belly firmness compared with LT-fed pigs (CON = 29.46°, LT = 35.16°, and ST = 42.08°; SE = 3.07). Dietary treatment had no effect (P > 0.60) on pork quality of loins based on taste panel assessments. Feeding pigs 8% crude glycerol throughout the grow-finish period resulted in a 3% improvement in growth rate and a 2% depression in BW gain efficiency compared with CON diets. Grow-finish pigs fed diets containing 8% crude glycerol during the last 8 wk before slaughter achieved growth performance similar to pigs fed CON diets. Effects of crude glycerol on carcass traits seem to be limited to improvements in belly firmness with short-term feeding of glycerol.

The Role of Intestinal Bacteria in Acute Diarrheal Diseases

DTIC Science & Technology

1981-01-01

another enteric pathogen, Vibrio cholerae , is present in high number in the cral cavity during acute and convalescent periods. Also, the buccal cells...h42 LT/ST + - - 2 K32&c4 AD) Kenya ... . .- r K32ScT All Kenya - LT - - - NT TD46ZcT ADY Mexfco 06:HT6 LT/ST - - - Z13 TD260cl AD Mexico 06:H16 LT...2 TD514c! AD Mexico .. . . NT TD472cI A Mexico LT/ST - - NT TD514cZ AD Mexico - NT "TABLE 1 CONTINUED 2 1 Enterotoxins MR-HA Pili 3 Human Strains

Pharmacokinetics and tissue distribution of parenterally administered human alpha-lymphotoxin in normal and meth-A tumor-bearing BALB/c mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Averbook, B.J.; Jeffes, E.B.; Yamamoto, R.S.

1989-08-01

These in vivo studies examine the pharmacokinetics of parenterally administered purified, native human alpha-lymphotoxin (LT) in normal and Meth-A bearing BALB/c mice. We found that the lytic activity of alpha-LT was inactivated within 5 h in the blood of both normal and tumor-bearing mice in vivo. However, LT bioactivity in vitro was not affected by incubation with fresh serum. Radioiodinated LT was rapidly sequestered in the kidneys of both normal and tumor-bearing animals. Systemically administered, radioiodinated LT did not selectively localize in tumor tissues.

An advanced stochastic weather generator for simulating 2-D high-resolution climate variables

NASA Astrophysics Data System (ADS)

Peleg, Nadav; Fatichi, Simone; Paschalis, Athanasios; Molnar, Peter; Burlando, Paolo

2017-07-01

A new stochastic weather generator, Advanced WEather GENerator for a two-dimensional grid (AWE-GEN-2d) is presented. The model combines physical and stochastic approaches to simulate key meteorological variables at high spatial and temporal resolution: 2 km × 2 km and 5 min for precipitation and cloud cover and 100 m × 100 m and 1 h for near-surface air temperature, solar radiation, vapor pressure, atmospheric pressure, and near-surface wind. The model requires spatially distributed data for the calibration process, which can nowadays be obtained by remote sensing devices (weather radar and satellites), reanalysis data sets and ground stations. AWE-GEN-2d is parsimonious in terms of computational demand and therefore is particularly suitable for studies where exploring internal climatic variability at multiple spatial and temporal scales is fundamental. Applications of the model include models of environmental systems, such as hydrological and geomorphological models, where high-resolution spatial and temporal meteorological forcing is crucial. The weather generator was calibrated and validated for the Engelberg region, an area with complex topography in the Swiss Alps. Model test shows that the climate variables are generated by AWE-GEN-2d with a level of accuracy that is sufficient for many practical applications.

Do Ligamentum Teres Tears Portend Inferior Outcomes in Patients With Borderline Dysplasia Undergoing Hip Arthroscopic Surgery? A Match-Controlled Study With a Minimum 2-Year Follow-up.

PubMed

Chaharbakhshi, Edwin O; Perets, Itay; Ashberg, Lyall; Mu, Brian; Lenkeit, Christopher; Domb, Benjamin G

2017-09-01

Arthroscopic surgery in borderline dysplastic hips remains controversial, but the role of the ligamentum teres (LT) has not been studied in this setting. Borderline dysplastic patients with LT tears have worse short-term outcomes than those without LT tears. Cohort study; Level of evidence, 3. Data were prospectively collected on patients who underwent arthroscopic surgery between February 2008 and April 2014. The inclusion criteria were borderline dysplasia (lateral center-edge angle [LCEA], 18°-25°) and labral tears; arthroscopic treatments including labral preservation and capsular plication; and preoperative patient-reported outcome scores including the modified Harris Hip Score (mHHS), Non-Arthritic Hip Score (NAHS), Hip Outcome Score-Sport-Specific Subscale, and visual analog scale for pain. Patients were excluded for preoperative Tönnis osteoarthritis grade >0, workers' compensation claims, previous ipsilateral hip surgery and conditions, or frank dysplasia (LCEA <18°). Patients with LT tears were pair-matched to patients without tears for sex, age at surgery ±10 years, body mass index (<30 kg/m 2 vs ≥30 kg/m 2 ), labral treatment type, and microfracture. Of 68 eligible patients, 63 (93%) had a minimum 2-year follow-up, and 30 (48%) had LT tears. Twenty patients in each group were pair-matched. The mean follow-up time was 54.3 months (range, 24.2-83.8 months) for the LT tear group and 38.6 months (range, 24.6-70.6 months) for the control group ( P = .002). Ninety percent were female. There were no significant differences regarding demographics or intra-operative procedures. The LT tear group trended toward lower postoperative mHHS ( P = .09) and NAHS ( P = .09) values. Mean satisfaction was 8.1 for the LT tear group and 7.9 for the control group. Preoperative and follow-up scores were not significantly different between the groups. The LT tear group had 5 revisions, with 1 revision in the control group. Three patients (15%) in the LT tear group underwent total hip arthroplasty (THA); no patients in the control group required THA. In borderline dysplastic patients undergoing hip arthroscopic surgery with labral treatment and capsular plication, LT tears may indicate advanced instability and portend slightly inferior outcomes when compared with a match-controlled group. Borderline dysplastic patients with LT tears may have increased propensities toward revision arthroscopic surgery and conversion to THA. LT tears in these patients may warrant consideration for additional procedures including periacetabular osteotomy and LT reconstruction.

CysLT2 receptor activation is involved in LTC4-induced lung air-trapping in guinea pigs.

PubMed

Sekioka, Tomohiko; Kadode, Michiaki; Yonetomi, Yasuo; Kamiya, Akihiro; Fujita, Manabu; Nabe, Takeshi; Kawabata, Kazuhito

2017-01-05

CysLT 1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT 2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT 2 receptor-mediated LTC 4 -induced lung air-trapping in guinea pigs and use this model to clarify the mechanism underlying response to such trapping. Because LTC 4 is rapidly converted to LTD 4 by γ-glutamyltranspeptidase (γ-GTP) under physiological conditions, S-hexyl GSH was used as a γ-GTP inhibitor. In anesthetized artificially ventilated guinea pigs with no S-hexyl GSH treatment, i.v. LTC 4 -induced bronchoconstriction was almost completely inhibited by montelukast, a CysLT 1 receptor antagonist, but not by BayCysLT 2 RA, a CysLT 2 receptor antagonist. The inhibitory effect of montelukast was diminished by treatment with S-hexyl GSH, whereas the effect of BayCysLT 2 RA was enhanced with increasing dose of S-hexyl GSH. Macroscopic and histological examination of lung tissue isolated from LTC 4 -/S-hexyl-GSH-treated guinea pigs revealed air-trapping expansion, particularly at the alveolar site. Inhaled LTC 4 in conscious guinea pigs treated with S-hexyl GSH increased both airway resistance and airway hyperinflation. On the other hand, LTC 4 -induced air-trapping was only partially suppressed by treatment with the bronchodilator salmeterol. Although montelukast inhibition of LTC 4 -induced air-trapping was weak, treatment with BayCysLT 2 RA resulted in complete suppression of this air-trapping. Furthermore, BayCysLT 2 RA completely suppressed LTC 4 -induced airway vascular hyperpermeability. In conclusion, we found in this study that CysLT 2 receptors mediate LTC 4 -induced bronchoconstriction and air-trapping in S-hexyl GSH-treated guinea pigs. It is therefore believed that CysLT 2 receptors contribute to asthmatic response involving air-trapping. Copyright © 2016 Elsevier B.V. All rights reserved.

Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer.

PubMed

Liang, Shuang; Hosur, Kavita B; Lu, Shanyun; Nawar, Hesham F; Weber, Benjamin R; Tapping, Richard I; Connell, Terry D; Hajishengallis, George

2009-03-01

The pentameric B subunit of type IIb Escherichia coli enterotoxin (LT-IIb-B(5)), a doughnut-shaped oligomeric protein from enterotoxigenic E. coli, activates the TLR2/TLR1 heterodimer (TLR2/1). We investigated the molecular basis of the LT-IIb-B(5) interaction with TLR2/1 to define the structure-function relationship of LT-IIb-B(5) and, moreover, to gain an insight into how TLR2/1 recognizes large, nonacylated protein ligands that cannot fit within its lipid-binding pockets, as previously shown for the Pam(3)CysSerLys(4) (Pam(3)CSK(4)) lipopeptide. We first identified four critical residues in the upper region of the LT-IIb-B(5) pore. Corresponding point mutants (M69E, A70D, L73E, S74D) were defective in binding TLR2 or TLR1 and could not activate APCs, despite retaining full ganglioside-binding capacity. Point mutations in the TLR2/1 dimer interface, as determined in the crystallographic structure of the TLR2/1-Pam(3)CSK(4) complex, resulted in diminished activation by both Pam(3)CSK(4) and LT-IIb-B(5). Docking analysis of the LT-IIb-B(5) interaction with this apparently predominant activation conformation of TLR2/1 revealed that LT-IIb-B(5) might primarily contact the convex surface of the TLR2 central domain. Although the TLR1/LT-IIb-B(5) interface is relatively smaller, the leucine-rich repeat motifs 9-12 in the central domain of TLR1 were found to be critical for cooperative TLR2-induced cell activation by LT-IIb-B(5). Moreover, the putative LT-IIb-B(5) binding site overlaps partially with that of Pam(3)CSK(4); consistent with this, Pam(3)CSK(4) suppressed TLR2 binding of LT-IIb-B(5), albeit not as potently as self-competitive inhibition. We identified the upper pore region of LT-IIb-B(5) as a TLR2/1 interactive domain, which contacts the heterodimeric receptor at a site that is distinct from, although it overlaps with, that of Pam(3)CSK(4).

Mapping of a Microbial Protein Domain Involved in Binding and Activation of the TLR2/TLR1 Heterodimer 1

PubMed Central

Liang, Shuang; Hosur, Kavita B.; Lu, Shanyun; Nawar, Hesham F.; Weber, Benjamin R.; Tapping, Richard I.; Connell, Terry D.; Hajishengallis, George

2009-01-01

LT-IIb-B5, a doughnut-shaped oligomeric protein from enterotoxigenic Escherichia coli, is known to activate the TLR2/TLR1 heterodimer (TLR2/1). We investigated the molecular basis of the LT-IIb-B5 interaction with TLR2/1 in order to define the structure-function relationship of LT-IIb-B5 and, moreover, to gain an insight into how TLR2/1 recognizes large, non-acylated protein ligands that cannot fit within its lipid-binding pockets, as previously shown for the Pam3CSK4 lipopeptide. We first identified four critical residues in the upper region of the LT-IIb-B5 pore: Corresponding point mutants (M69E, A70D, L73E, S74D) were defective in binding TLR2 or TLR1 and could not activate antigen-presenting cells, despite retaining full ganglioside-binding capacity. Point mutations in the TLR2/1 dimer interface, as determined in the crystallographic structure of the TLR2/1-Pam3CSK4 complex, resulted in diminished activation by both Pam3CSK4 and LT-IIb-B5. Docking analysis of the LT-IIb-B5 interaction with this apparently “predominant” activation conformation of TLR2/1 revealed that LT-IIb-B5 may primarily contact the convex surface of the TLR2 central domain. Although the TLR1/LT-IIb-B5 interface is relatively smaller, the leucine-rich repeat motifs 9–12 in the central domain of TLR1 were found to be critical for cooperative TLR2-induced cell activation by LT-IIb-B5. Moreover, the putative LT-IIb-B5 binding site overlaps partially with that of Pam3CSK4; consistent with this, Pam3CSK4 suppressed TLR2 binding of LT-IIb-B5, albeit not as potently as self-competitive inhibition. In conclusion, we identified the upper pore region of LT-IIb-B5 as a TLR2/1 interactive domain, which contacts the heterodimeric receptor at a site that is distinct from, though overlaps with, that of Pam3CSK4. PMID:19234193

A Study of the Air Force’s Current Method of Training Individuals to Use Contractor Developed Software in Information Management and the Perceived Effectiveness of Training

DTIC Science & Technology

1990-12-01

and only one Navy study was located. Lt. Cynthia S. Lassnoff (USN) conducted a case analysis of the training requirements of Navy microcomputer users...effectiveness of the training. The study found that greater emphasis must be placed on developing and supporting the use of a standardized training...recommends areas of further research based on the findings of this research. 1-8 II. Background No previous studies were located that evaluated how the Air

Approaches to Post-Conflict Peacebuilding: The UK Post-Conflict Reconstruction Unit (PCRU) and US Office for the Coordinator of Reconstruction and Stabilization (S/CRS)

DTIC Science & Technology

2006-09-01

POST-CONFLICT PEACEBUILDING: THE UK POST-CONFLICT RECONSTRUCTION UNIT (PCRU) AND US OFFICE FOR THE COORDINATOR OF RECONSTRUCTION AND STABILIZATION ( S ...CRS) 6. AUTHOR( S ) 2D LT KRIEGER MIRIAM A 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION KINGS COLLEGE REPORT NUMBER CI04...1874 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSORING/MONITORING THE DEPARTMENT OF THE AIR FORCE AGENCY REPORT NUMBER AFIT/CIA