The modern brain tumor operating room: from standard essentials to current state-of-the-art.

PubMed

Barnett, Gene H; Nathoo, Narendra

2004-01-01

It is just over a century since successful brain tumor resection. Since then the diagnosis, imaging, and management of brain tumors have improved, in large part due to technological advances. Similarly, the operating room (OR) for brain tumor surgery has increased in complexity and specificity with multiple forms of equipment now considered necessary as technical adjuncts. It is evident that the theme of minimalism in combination with advanced image-guidance techniques and a cohort of sophisticated technologies (e.g., robotics and nanotechnology) will drive changes in the current OR environment for the foreseeable future. In this report we describe what may be regarded today as standard essentials in an operating room for the surgical management of brain tumors and what we believe to be the current 'state-of-the-art' brain tumor OR. Also, we speculate on the additional capabilities of the brain tumor OR of the near future.

Surveillance of dengue fever virus: a review of epidemiological models and early warning systems.

PubMed

Racloz, Vanessa; Ramsey, Rebecca; Tong, Shilu; Hu, Wenbiao

2012-01-01

Dengue fever affects over a 100 million people annually hence is one of the world's most important vector-borne diseases. The transmission area of this disease continues to expand due to many direct and indirect factors linked to urban sprawl, increased travel and global warming. Current preventative measures include mosquito control programs, yet due to the complex nature of the disease and the increased importation risk along with the lack of efficient prophylactic measures, successful disease control and elimination is not realistic in the foreseeable future. Epidemiological models attempt to predict future outbreaks using information on the risk factors of the disease. Through a systematic literature review, this paper aims at analyzing the different modeling methods and their outputs in terms of acting as an early warning system. We found that many previous studies have not sufficiently accounted for the spatio-temporal features of the disease in the modeling process. Yet with advances in technology, the ability to incorporate such information as well as the socio-environmental aspect allowed for its use as an early warning system, albeit limited geographically to a local scale.

A Hybrid Satellite-Terrestrial Approach to Aeronautical Communication Networks

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Chomos, Gerald J.; Griner, James H.; Mainger, Steven W.; Martzaklis, Konstantinos S.; Kachmar, Brian A.

2000-01-01

Rapid growth in air travel has been projected to continue for the foreseeable future. To maintain a safe and efficient national and global aviation system, significant advances in communications systems supporting aviation are required. Satellites will increasingly play a critical role in the aeronautical communications network. At the same time, current ground-based communications links, primarily very high frequency (VHF), will continue to be employed due to cost advantages and legacy issues. Hence a hybrid satellite-terrestrial network, or group of networks, will emerge. The increased complexity of future aeronautical communications networks dictates that system-level modeling be employed to obtain an optimal system fulfilling a majority of user needs. The NASA Glenn Research Center is investigating the current and potential future state of aeronautical communications, and is developing a simulation and modeling program to research future communications architectures for national and global aeronautical needs. This paper describes the primary requirements, the current infrastructure, and emerging trends of aeronautical communications, including a growing role for satellite communications. The need for a hybrid communications system architecture approach including both satellite and ground-based communications links is explained. Future aeronautical communication network topologies and key issues in simulation and modeling of future aeronautical communications systems are described.

ECOSYSTEM IMPACTS OF GEOENGINEERING: A Review for Developing a Science Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russell, Lynn M; Jackson, Robert B; Norby, Richard J

2012-01-01

Geoengineering methods are intended to reduce the magnitude of climate change, which is already having demonstrable effects on ecosystem structure and functioning. Two different types of activities have been proposed: solar radiation management (SRM), or sunlight reflection methods, which involves reflecting a small percentage of solar light back into space to offset the warming due to greenhouse gases, and carbon dioxide removal (CDR), which includes a range of engineered and biological processes to remove carbon dioxide (CO2) from the atmosphere. This report evaluates some of the possible impacts of CDR and SRM on the physical climate and their subsequent influencemore » on ecosystems, which include the risks and uncertainties associated with new kinds of purposeful perturbations to the Earth. Therefore, the question considered in this review is whether CDR and SRM methods would exacerbate or alleviate the deleterious impacts on ecosystems associated with climate changes that might occur in the foreseeable future.Geoengineering methods are intended to reduce the magnitude of climate change, which is already having demonstrable effects on ecosystem structure and functioning. Two different types of activities have been proposed: solar radiation management (SRM), or sunlight reflection methods, which involves reflecting a small percentage of solar light back into space to offset the warming due to greenhouse gases, and carbon dioxide removal (CDR), which includes a range of engineered and biological processes to remove carbon dioxide (CO2) from the atmosphere. This report evaluates some of the possible impacts of CDR and SRM on the physical climate and their subsequent influence on ecosystems, which include the risks and uncertainties associated with new kinds of purposeful perturbations to the Earth. Therefore, the question considered in this review is whether CDR and SRM methods would exacerbate or alleviate the deleterious impacts on ecosystems associated with climate changes that might occur in the foreseeable future.« less

Seismic retrofit benefit considering statewide transportation assessment.

DOT National Transportation Integrated Search

2015-06-01

The purpose of this study was to identify and demonstrate a methodology to prioritize bridges for : retrofit in the State of Oregon. Given the limited resources available, retrofitting all vulnerable bridges in the foreseeable : future would not be i...

50 CFR 424.11 - Factors for listing, delisting, or reclassifying species.

Code of Federal Regulations, 2012 CFR

2012-10-01

... more of the following reasons: (1) Extinction. Unless all individuals of the listed species had been... nation, or to be in danger of extinction or likely to become so within the foreseeable future by any...

50 CFR 424.11 - Factors for listing, delisting, or reclassifying species.

Code of Federal Regulations, 2014 CFR

2014-10-01

... more of the following reasons: (1) Extinction. Unless all individuals of the listed species had been... nation, or to be in danger of extinction or likely to become so within the foreseeable future by any...

50 CFR 424.11 - Factors for listing, delisting, or reclassifying species.

Code of Federal Regulations, 2010 CFR

2010-10-01

... more of the following reasons: (1) Extinction. Unless all individuals of the listed species had been... nation, or to be in danger of extinction or likely to become so within the foreseeable future by any...

50 CFR 424.11 - Factors for listing, delisting, or reclassifying species.

Code of Federal Regulations, 2011 CFR

2011-10-01

... more of the following reasons: (1) Extinction. Unless all individuals of the listed species had been... nation, or to be in danger of extinction or likely to become so within the foreseeable future by any...

77 FR 28316 - Filing a Renewed License Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... only those environmental impacts and alternatives that are reasonably foreseeable. This means that... action timeframe. With respect to assessing the potential future environmental impacts associated with... its consideration of impacts in the generic and supplemental environmental impact statements (SEISs...

A SWOT Analysis of Big Data

ERIC Educational Resources Information Center

Ahmadi, Mohammad; Dileepan, Parthasarati; Wheatley, Kathleen K.

2016-01-01

This is the decade of data analytics and big data, but not everyone agrees with the definition of big data. Some researchers see it as the future of data analysis, while others consider it as hype and foresee its demise in the near future. No matter how it is defined, big data for the time being is having its glory moment. The most important…

Blind Optimism: A Cross-Cultural Study of Students' Temporal Constructs and Their Schooling Engagements

ERIC Educational Resources Information Center

Rossatto, Cesar Augusto

2004-01-01

This article examines students' perceptions and usage of time, their sense of optimism or lack of it, especially related to schooling. Positionality, or perceptions about life and projections of the future, has great impact on students' success in school. How they interpret the past, live in the present and foresee the future is significantly…

Information, knowledge and the future of machines.

PubMed

MacFarlane, Alistair G J

2003-08-15

This wide-ranging survey considers the future of machines in terms of information, complexity and the growth of knowledge shared amongst agents. Mechanical and human agents are compared and contrasted, and it is argued that, for the foreseeable future, their roles will be complementary. The future development of machines is examined in terms of unions of human and machine agency evolving as part of economic activity. Limits to, and threats posed by, the continuing evolution of such a society of agency are considered.

Deep Learning in Medical Imaging: General Overview

PubMed Central

Lee, June-Goo; Jun, Sanghoon; Cho, Young-Won; Lee, Hyunna; Kim, Guk Bae

2017-01-01

The artificial neural network (ANN)–a machine learning technique inspired by the human neuronal synapse system–was introduced in the 1950s. However, the ANN was previously limited in its ability to solve actual problems, due to the vanishing gradient and overfitting problems with training of deep architecture, lack of computing power, and primarily the absence of sufficient data to train the computer system. Interest in this concept has lately resurfaced, due to the availability of big data, enhanced computing power with the current graphics processing units, and novel algorithms to train the deep neural network. Recent studies on this technology suggest its potentially to perform better than humans in some visual and auditory recognition tasks, which may portend its applications in medicine and healthcare, especially in medical imaging, in the foreseeable future. This review article offers perspectives on the history, development, and applications of deep learning technology, particularly regarding its applications in medical imaging. PMID:28670152

Deep Learning in Medical Imaging: General Overview.

PubMed

Lee, June-Goo; Jun, Sanghoon; Cho, Young-Won; Lee, Hyunna; Kim, Guk Bae; Seo, Joon Beom; Kim, Namkug

2017-01-01

The artificial neural network (ANN)-a machine learning technique inspired by the human neuronal synapse system-was introduced in the 1950s. However, the ANN was previously limited in its ability to solve actual problems, due to the vanishing gradient and overfitting problems with training of deep architecture, lack of computing power, and primarily the absence of sufficient data to train the computer system. Interest in this concept has lately resurfaced, due to the availability of big data, enhanced computing power with the current graphics processing units, and novel algorithms to train the deep neural network. Recent studies on this technology suggest its potentially to perform better than humans in some visual and auditory recognition tasks, which may portend its applications in medicine and healthcare, especially in medical imaging, in the foreseeable future. This review article offers perspectives on the history, development, and applications of deep learning technology, particularly regarding its applications in medical imaging.

Evaluating the economic viability of a material recovery system: the case of cathode ray tube glass.

PubMed

Gregory, Jeremy R; Nadeau, Marie-Claude; Kirchain, Randolph E

2009-12-15

This paper presents an analysis of the material recovery system for leaded glass from cathode ray tubes (CRTs) using a dynamic material flow analysis. In particular, the global mass flow of primary and secondary CRT glass and the theoretical capacities for using secondary CRT glass to make new CRT glass are analyzed. The global mass flow analysis indicates that the amount of new glass required is decreasing, but is much greater than the amount of secondary glass collected, which is increasing. The comparison of the ratio of secondary glass collected to the amount of new glass required from the mass flow analysis indicates that the material recovery system is sustainable for the foreseeable future. However, a prediction of the time at which the market for secondary glass will collapse due to excess capacity is not possible at the moment due to several sources of uncertainty.

Hybrid Laser/GMAW of High Strength Steel Gas Transmission Pipelines

DOT National Transportation Integrated Search

2008-07-01

Pipelines will be an integral part of our energy distribution systems for the foreseeable future. Operators are currently considering the installation of tens of billions of dollars of pipeline infrastructure. In a number of cases, the cost of export...

Illusions and Ignorance about the Family-Responsive Workplace.

ERIC Educational Resources Information Center

Kingston, Paul W.

1990-01-01

Contends American businesses have made modest headway in instituting family-responsive practices and that it is illusory to expect that market solutions will deliver good or equitable family policy in foreseeable future. Predicts uneven realization of the responsive workplace. (Author/ABL)

Best practices in guidance for workforce transition and succession planning.

DOT National Transportation Integrated Search

2011-04-01

Public sector transportation agencies and the contractors who help them do their work will have a major challenge in meeting their : workforce needs for the foreseeable future. By some estimates, the aging of the baby boom generation could allow up t...

Best practices in guidance for workforce transition and succession planning.

DOT National Transportation Integrated Search

2011-04-01

"Public sector transportation agencies and the contractors who help them do their work will have a major challenge in meeting their : workforce needs for the foreseeable future. By some estimates, the aging of the baby boom generation could allow up ...

Environmental impacts of biofuel production and use

EPA Science Inventory

The 2007 Energy Independence and Security Act (EISA) required a significant increase in the production and use of renewable fuels. Given the current state of technology and infrastructure, nearly all of the projected volume of biofuel consumption over the foreseeable future is ex...

Feasibility study for liquefied natural gas utilization for commercial vehicles on the Pennsylvania Turnpike.

DOT National Transportation Integrated Search

2012-10-01

Recent advances in horizontal drilling and fracturing technology in gas shale formations have increased natural gas supply : such that its price has decoupled from petroleum and is likely to remain significantly lower for the foreseeable future. In t...

The Fairness Debate in U.S.-Japan Economic Relations

DTIC Science & Technology

1991-01-01

economic growth for the foreseeable future; any developments that threaten to undermine it would have enormous consequences for the future of the...foreign businesses. The Japanese view U.S. macroeconomic policy failure as the principal cause of the fairness dispute. There is rep- utable economic...number of comparable political problems. Stereotyping of the other 2 The reason for the dramatic growth of fairness grievances in advanced industrial

Strategic planning features of subsurface management in Kemerovo Oblast

NASA Astrophysics Data System (ADS)

Romanyuk, V.; Grinkevich, A.; Akhmadeev, K.; Pozdeeva, G.

2016-09-01

The article discusses the strategic planning features of regional development based on the production and subsurface management in Kemerovo Oblast. The modern approach - SWOT analysis was applied to assess the regional development strategy. The estimation of regional development plan implementation was given for the foreseeable future.

40 CFR 1508.7 - Cumulative impact.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Cumulative impact. 1508.7 Section 1508... Cumulative impact. Cumulative impact is the impact on the environment which results from the incremental impact of the action when added to other past, present, and reasonably foreseeable future actions...

A Response to Mortimer Adler's "Paideia Proposal."

ERIC Educational Resources Information Center

Gregory, Marshall W.

1984-01-01

Offers a critique of Adler's position on common learning and the future of American education. Sympathizes with Adler's objectives, but sees three flaws inherent in his polemics. Foresees no realization of objectives through Adler's manifesto, but finds it useful for clarifying ideas and generating philosophical discussion. (DMM)

Incertitude in disaster sciences and scientists' responsibilities: A case study of the L'Aquila earthquake trial

NASA Astrophysics Data System (ADS)

Koketsu, Kazuki; Oki, Satoko

2015-04-01

What disaster sciences are expected by the society is to prevent or mitigate future natural disasters, and therefore it is necessary to foresee natural disasters. However, various constraints often make the foreseeing difficult so that there is a high incertitude in the social contribution of disaster sciences. If scientists overstep this limitation, they will be held even criminally responsible. The L'Aquila trial in Italy is such a recent example and so we have performed data collections, hearing investigations, analyses of the reasons for the initial court's judgment, etc., to explore the incertitude of disaster sciences and scientists' responsibilities. As a result, we concluded that the casualties during the L'Aquila earthquake were mainly due to a careless "safety declaration" by the vice-director of the Civil Protection Agency, where the incertitude of disaster sciences had never been considered. In addition, news media which reported only this "safety declaration" were also seriously responsible for the casualties. The accused other than the vice-director were only morally responsible, because their meeting remarks included poor risk communication in disaster sciences but those were not reported to the citizens in advance to the L'Aquila earthquake. In the presentation, we will also discuss the similarities and differences between our conclusions above and the reasons for the appeals court's judgement, which will be published in February.

Status of geothermal direct use in Poland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bujakowski, W.

1997-12-31

Geothermal Energy uses the natural heat of the Earth. It is a local energy source, competitive, renewable and acceptable from the ecological and social points of view, which is used either for the electricity production, or for direct application such as a district heating. A great number of operating geothermal installations are found in Europe. European Community energy programs foresee in the coming years a great reduction of conventional fuel consumption, due to the risks that dependency on imported fuels implies and to the future environmental problems, which a mass exploitation of these fuels can lead to. Thus, EC energymore » policy is aimed at a drastic reduction of oil consumption and at diversification of primary energy sources. This paper will present the results from the exploration and evaluation of geothermal water resources in Poland. Herewith, a short description of performed projects, examples of designed geothermal water utilization, some economical, sociological, ecological and political aspects of present out and future projects will be presented.« less

IMPLEMENTATION OF GASTRIC CANCER SCREENING – THE GLOBAL EXPERIENCE

PubMed Central

Leja, Mārcis; You, Weicheng; Camargo, M. Constanza; Saito, Hiroshi

2018-01-01

Gastric cancer (GC) is still an important global healthcare problem, and in absolute figures it is going to remain at the present level in foreseeable future. In general, survival of patients with GC is poor mainly due to advanced-stage diagnosis. Early-stage GC can be cured by endoscopic resection or less invasive surgical treatment. Unfortunately, there is no appropriate screening strategy available for global application. This article provides a description of established national and regional GC screening programs and the screening modalities used. This review also summarizes current approaches to develop cancer-screening biomarkers. Although candidates with initial promising results have been suggested, moving discovery into clinical practice is still a major challenge. Well-designed biomarker studies, with systematic validation steps, are needed to decrease the burden of this fatal disease. PMID:25439074

20 CFR 617.19 - Requirement for participation in training.

Code of Federal Regulations, 2010 CFR

2010-04-01

... available at a reasonable cost, (D) Funds are not available to pay the total costs of training, or (E... which the individual was separated plans to recall the individual within the reasonably foreseeable future (State agencies must verify planned recalls with the employer), (2) Planned recall. For the...

Space prospects. [european space programs

NASA Technical Reports Server (NTRS)

1980-01-01

A strategy for keeping the Common Market's space effort independent of and competitive with NASA and the space shuttle is discussed. Limited financing is the chief obstacle to this. Proposals include an outer space materials processing project and further development of the Ariane rocket. A manned space program is excluded for the foreseeable future.

Insure Thyself: A Look at Alternatives

ERIC Educational Resources Information Center

Weeks, Richard

2011-01-01

Annual double-digit increases in health insurance premiums may be the reality for school districts and private-sector employers for the foreseeable future. The author presents several factors that account for this unwelcome possibility. One cost-saving alternative for districts is to self-insure employees and assume the risks. Districts are…

Navigating Disruptive Innovation in Undergraduate Business Education

ERIC Educational Resources Information Center

Behara, Ravi S.; Davis, Mark M.

2015-01-01

The undergraduate business education landscape is dramatically changing and will continue to do so for the foreseeable future. Many of the changes are being driven by increasing costs, advances in technology, rapid globalization, and an increasingly diverse workforce and customer base, and are occurring simultaneously in both the business world…

FT-Raman Spectroscopy: A Catalyst for the Raman Explosion?

ERIC Educational Resources Information Center

Chase, Bruce

2007-01-01

The limitations of Fourier transform (FT) Raman spectroscopy, which is used to detect and analyze the scattered radiation, are discussed. FT-Raman has served to revitalize a field that was lagging and the presence of Raman instrumentation as a routine analytical tool is established for the foreseeable future.

A Changing Society: New Perspectives for Science Education.

ERIC Educational Resources Information Center

Hurd, Paul DeHart

Perspectives on the reconstruction of science education in terms of current economic and social conditions and the foreseeable future are presented in this publication. An acceptable science curriculum is described as one that has cultural as well as scientific and technological validity. Elements that have been identified as essential for the…

Building a "cyber forest" in complex terrain at the Andrews Experimental Forest

Treesearch

Donald L. Henshaw; Fred Bierlmaier; Barbara J. Bond; Kari B. O' Connell

2008-01-01

Our vision for a future "cyber forest" at the Andrews Experimental Forest foresees high performance wireless communications enhancing connectivity among remote field research locations, station headquarters, and beyond to the university and outside world. New sensor technologies and collaboration tools foretell exponential increases in data and information...

How Advertising History Helps Explain Current Practices.

ERIC Educational Resources Information Center

Lanfranco, Leonard W.

Students majoring in advertising can benefit from a study of that field in its historical context because such study helps them to understand current practices and to foresee future developments. One model of teaching advertising history within a required course about advertising and society begins with some basic definitions of the advertising…

Deploying the Win TR-20 computational engine as a web service

USDA-ARS?s Scientific Manuscript database

Despite its simplicity and limitations, the runoff curve number method remains a widely-used hydrologic modeling tool, and its use through the USDA Natural Resources Conservation Service (NRCS) computer application WinTR-20 is expected to continue for the foreseeable future. To facilitate timely up...

ORGANIC SULFUR AND HAP REMOVAL FROM COAL USING HYDROTHERMAL TREATMENT. (R827649C001)

EPA Science Inventory

Coal is still the major source of power for electrical generation worldwide and will continue to be in
the foreseeable future. However, the inorganic elements in coal that qualify as hazardous emissions
upon combustion of the coal become an increasingly important concern. P...

Monthly modulation in dark matter direct-detection experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Britto, Vivian; Meyers, Joel, E-mail: vivian.britto@mail.utoronto.ca, E-mail: jmeyers@cita.utoronto.ca

2015-11-01

The signals in dark matter direct-detection experiments should exhibit modulation signatures due to the Earth's motion with respect to the Galactic dark matter halo. The annual and daily modulations, due to the Earth's revolution about the Sun and rotation about its own axis, have been explored previously. Monthly modulation is another such feature present in direct detection signals, and provides a nearly model-independent method of distinguishing dark matter signal events from background. We study here monthly modulations in detail for both WIMP and WISP dark matter searches, examining both the effect of the motion of the Earth about the Earth-Moonmore » barycenter and the gravitational focusing due to the Moon. For WIMP searches, we calculate the monthly modulation of the count rate and show the effects are too small to be observed in the foreseeable future. For WISP dark matter experiments, we show that the photons generated by WISP to photon conversion have frequencies which undergo a monthly modulating shift which is detectable with current technology and which cannot in general be neglected in high resolution WISP searches.« less

Military’s Peacetime Role (Implications of the Civilian Conservation Corps Experience)

DTIC Science & Technology

1986-06-06

containing data and opinion pertinent to various study orientetions . Throughout the literature there are numaeroum but scattered references to the impact of...was indirect and evidenced only by extrapolation. President Roosevelt had predicted that CCC work would be "a means of creating future national wealth...foreseeable future . 2 5 There was virtually no chance of a situation that would require a military response. Furthermore, if the General Staff had 122 thought

Are We There Yet? Alternative Fuels for School Buses

ERIC Educational Resources Information Center

Lea, Dennis; Carter, Deborah

2009-01-01

America's annual oil consumption continues to increase and is projected to continue the upward spiral into the foreseeable future. Alternative-fuel options are available that are not only cheaper in some cases on an energy-equivalent basis but are also more environmentally friendly. Education leaders need to be concerned with both these facts.…

Reading for Learning: Literacy Supports for 21st-Century Work

ERIC Educational Resources Information Center

Gomez, Louis M.; Gomez, Kimberley

2007-01-01

The U.S. work force is changing. Professional and related occupations and service occupations will be the fastest-growing sectors for the foreseeable future. Both demand strong communication skills for sharing complex ideas across diverse communities. In addition, the 21st-century economy will require its members to think creatively and critically…

Mind Altering Drugs and the Future

ERIC Educational Resources Information Center

Evans, Wayne O.

1971-01-01

A researcher in psychopharmacology foresees a flood of new drugs that will make man feel happy, cause him to forget his past, and arouse his sexual desires. Man may actually have the possibility of attaining sustained happiness, or something like it, through drugs, and so must ask the question, Is happiness what I most want?" (Author)

18 CFR 2.23 - Use of reserved authority in hydropower licenses to ameliorate cumulative impacts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL... such articles will describe, to the maximum extent possible, reasonably foreseeable future resource... “reopener” articles (see § 2.9 of this part) which reserve authority to the Commission to require, among...

Verification of the Integrity and Legitimacy of Academic Credential Documents in an International Setting

ERIC Educational Resources Information Center

Gollin, George D.

2009-01-01

The global demand for higher education currently exceeds the world's existing university capacity. This shortfall is likely to persist for the foreseeable future, raising concerns that frustrated students might choose to purchase fraudulent credentials from counterfeiters or diploma mills. International efforts to encourage the development of…

Searching for the Grand Unifying Theory: Reflections on the Field of LD

ERIC Educational Resources Information Center

Rueda, Robert

2005-01-01

A recent overview of the field of learning disabilities (Torgesen, 2004) laid out several issues that will likely consume the field for the foreseeable future, including problems of definition and etiology, differentiation of learning disabilities from other disabilities, and issues in identification and service delivery. It has been approximately…

The Future of Pathology: A Delphi Study by Pathology Department Chairmen

ERIC Educational Resources Information Center

Goodale, Fairfield; Gander, George W.

1976-01-01

Over 100 department chairmen in American and Canadian medical schools participated in this questionnaire study. Most are deeply concerned about increasing federal regulation of medicine, expect more emphasis on the basic science aspects of pathology, and foresee a shift of residency training programs away from small hospitals to larger medical…

Hierarchical filters determine community assembly of urban species pools

Treesearch

Myla F.J. Aronson; Charles H. Nilon; Christopher A. Lepczyk; Tommy S. Parker; Paige S. Warren; Sarel S. Cilliers; Mark A. Goddard; Amy K. Hahs; Cecilia Herzog; Madhusudan Katti; Frank A. La Sorte; Nicholas S.G. Williams; Wayne  Zipperer

2016-01-01

The majority of humanity now lives in cities or towns, with this proportion expected to continue increasing for the foreseeable future. As novel ecosystems, urban areas offer an ideal opportunity to examine multi-scalar processes involved in community assembly as well as the role of human activities in modulating environmental drivers of biodiversity. Although...

78 FR 47582 - Endangered and Threatened Wildlife and Plants; Endangered Species Status for the Sharpnose Shiner...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... analysis of the best available science and application of that science and to provide any additional... in these areas of science are limited, some uncertainties are associated with this assessment. Where... in the foreseeable future (threatened species). Because of the fact-specific nature of listing...

New Developments on the Turkish School Library Scene

ERIC Educational Resources Information Center

Onal, H. Inci

2005-01-01

The overall purpose of this article is to describe the history, growth and development of school libraries in Turkey from 1923 to 2004. For now and the foreseeable future, school librarians will be simultaneously working in the library of yesterday and deeply affected by the library of tomorrow. Changing information needs make it necessary to…

Problems and Alternatives in Housing Students: What a School Business Administrator Should Know.

ERIC Educational Resources Information Center

Earthman, Glen I.

1984-01-01

Reviews factors that could influence planning for the provision of educational facilities in the foreseeable future: new enrollment projections, the need to address deferred maintenance problems, recent educational reform efforts, the needs of new programs, recent tax limitation measures, court action, and new approaches to raising funds. (PGD)

Promoting Undergraduate Student Self-Regulation in Online Learning Environments

ERIC Educational Resources Information Center

Wandler, J. Brad; Imbriale, William J.

2017-01-01

Undergraduate student enrollment in online courses has steadily increased over the years and is expected to continue for the foreseeable future. The need for instructors to utilize best practices in online instruction and course design is crucial. This article presents strategies for online instructors to promote student use of self-regulated…

International Education and IB Programmes: Worldwide Expansion and Potential Cultural Dissonance

ERIC Educational Resources Information Center

Drake, Barry

2004-01-01

It has been suggested that the International Baccalaureate Organization could be expected to "influence" as many as 100 million people in the foreseeable future. This article focuses on some of the cultural dissonances that may be produced from attempts to "clone" on to non-Eurocentric models, educational systems and methodologies designed to…

College Fundraising: Is There a "New Normal"?

ERIC Educational Resources Information Center

Bass, David

2009-01-01

The fall of 2008 was a bleak time for college and university leaders. While there was little doubt that state funding would be down for the foreseeable future and general agreement that endowments would take a long while to recover, no consensus existed about the potential impact of the financial crisis on college and university development…

A Hunger Strike on Campus

ERIC Educational Resources Information Center

Dawson, John B.

1970-01-01

This article describes a recent student fast" that occurred on the Stony Brook campus as a peaceful means of protest against Department of Defense research. The purpose of this report is to generate discussion and to stimulate preparation for dealing with similar fasts", since they are likely to occur on other campuses in the foreseeable future.…

Immigration and the New Racial Diversity in Rural America

ERIC Educational Resources Information Center

Lichter, Daniel T.

2012-01-01

This article highlights the new racial and ethnic diversity in rural America, which may be the most important but least anticipated population shift in recent demographic history. Ethnoracial change is central to virtually every aspect of rural America over the foreseeable future: agro-food systems, community life, labor force change, economic…

Wood Formation in Trees

Treesearch

Melanie Mauriat; Gregoire Le Provost; Phillippe Rozenberg; Sylvain Delzon; Nathalie Breda; Bruno Clair; Catherine Coutand; Jean-Christoph Domec; Thierry Fourcaud; Jacqueline Grima-Pettenati; Raul Herrera; Jean-Charles Leple; Nicolas Richet; Jean-Francois Trontin; Christophe Plomion

2014-01-01

Among the ecosystem services provided by forests, wood provisioning takes a central position. Wood and derived products have played a critical role in the evolution of human kind and demand for raw material is increasing in a foreseeable future. Wood is used for energy production, construction and a wide variety of products for which different properties are required....

25. Cumulative effects assessment impact thresholds: myths and realities

Treesearch

Robert R. Ziemer

1994-01-01

A cumulative impact has been commonly defined as: ""...the impact on the environment which results from the incremental impact of the action when added to other past, present, and reasonably foreseeable future actions regardless of what agency or person undertakes such other actions. Cumulative impacts can result from individually minor but collectively...

A Compelling Interest: Activating the Benefits of Classroom-Level Diversity

ERIC Educational Resources Information Center

Haslerig, Siduri; Bernhard, Laura M.; Fuentes, Marcia V.; Panter, A. T.; Daye, Charles E.; Allen, Walter R.

2013-01-01

The use of affirmative action admissions practices in U.S. colleges and universities has been a source of contentious public debate and legal battles since the policy's inception in the 1960s. The legal challenges to race-conscious admissions will continue for the foreseeable future, including renewed court scrutiny on specific universities'…

Reflections on the Future Development of Education.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

Designed to explore the prospects for the development of education throughout the 1980s and 1990s, this study looked at general trends in education in the course of the 1970s, socio-economic evolution in the world, and foreseeable advances in science and technology, in order to outline the priorities for international cooperation. Within the…

Impact of emerging technologies on future combat aircraft agility

NASA Technical Reports Server (NTRS)

Nguyen, Luat T.; Gilert, William P.

1990-01-01

The foreseeable character of future within-visual-range air combat entails a degree of agility which calls for the integration of high-alpha aerodynamics, thrust vectoring, intimate pilot/vehicle interfaces, and advanced weapons/avionics suites, in prospective configurations. The primary technology-development programs currently contributing to these goals are presently discussed; they encompass the F-15 Short Takeoff and Landing/Maneuver Technology Demonstrator Program, the Enhanced Fighter Maneuverability Program, the High Angle-of-Attack Technology Program, and the X-29 Technology Demonstrator Program.

Computer graphics and cultural heritage, part 2: continuing inspiration for future tools.

PubMed

Arnold, David

2014-01-01

The availability of large quantities of cultural-heritage data will enable new, previously inconceivable, types of analysis and new applications. Currently, most emerging analysis methods are experimental research. It's likely to take many years before the research matures and provides cultural-heritage professionals with novel research methods that they use routinely. Indeed, we can expect further disruptive technologies to emerge in the foreseeable future and a "steady state" of continuing rapid change. Part 1 can be found at 10.1109/MCG.2014.47.

Charting the future of hospital nursing.

PubMed

Aiken, L H

1990-01-01

Nursing roles are expanding in all health care settings; however, the majority of nurses will continue to practice in hospitals for the foreseeable future. Yet hospital nursing is experiencing great ferment and turmoil. Nurses are dissatisfied increasingly with hospital practice, and vacancy and turnover rates are high enough to raise major concerns about adverse consequences for patients. This paper focuses on the nature and causes of the current problems in hospital nursing and advances recommendations for charting a new course for hospital nursing.

Preserving the American Dream: A Teacher-Turned-Congressman Starts a National Dialogue on Equity

ERIC Educational Resources Information Center

Honda, Michael

2011-01-01

While the worst of the Great Recession has passed, it has become clear that persistently high unemployment, coupled with budget woes that stretch from federal to local government, will be a reality for the foreseeable future. Knowing this, Congress, the Obama administration, and constituents across the country are having a serious discussion about…

Environmental Assessment for Construction of the Distributed Common Ground Station (DCGS) at Langley Air Force Base, Virginia

DTIC Science & Technology

2007-03-01

located in the north-central part of the base and includes the areas occupied by the golf course clubhouse , maintenance building, and the driving range...foreseeable future actions regardless of what agency or person undertakes such other actions” (40 CFR 1508.7). Recent CEQ guidance in Considering

Why Mechanics Should Be Integral to Secondary School Mathematics

ERIC Educational Resources Information Center

Rowlands, Stuart

2008-01-01

Mechanics has never been the most popular subject in A-level mathematics, the UK's public examination for 16-18-year olds, either with students, teachers or educators. The attempts to popularize mechanics have failed and it is conceivable that the subject will be dropped from the A-level syllabus in the foreseeable future. This article argues the…

Problem-Based Conversations: Using Preservice Teachers' Problems as a Mechanism for Their Professional Development

ERIC Educational Resources Information Center

Miller, Matthew

2008-01-01

Which Learning to teach is a challenge. When people make the decision to become teachers, they enter their undergraduate, postbaccalaureate, graduate, or alternative teacher education programs with a goal of learning how to teach so their future students learn. Many teacher candidates, understandably, do not foresee the complexity of the journey…

The Future of Management as Design: A Thought Experiment

ERIC Educational Resources Information Center

Bouchard, Veronique; del Forno, Leon

2012-01-01

Purpose: Management practices and education are presently in a stage of reappraisal and a growing number of scholars and experts are suggesting that managers should be taught and adopt the approach and methodologies of designers. The purpose of this paper is to imagine the impact of this move and to try and foresee whether "management as design"…

Addressing the Biggest (Baddest) and Best Ideas Ever: Through the Lens of Humility

ERIC Educational Resources Information Center

Sowcik, Matthew J.; Andenoro, Anthony C.; Council, Austin

2017-01-01

Now and into the foreseeable future, both effective leadership and creativity are going to be important when addressing complex problems. The connection between effective leadership and creativity will be critical as leaders look to turn big ideas into innovative solutions. However, it seems that there is often a disconnect between the two…

Albuquerque Public Schools Student Enrollment: History & Forecast 1954-1994. 1975 APS Planning Document 1.

ERIC Educational Resources Information Center

Albuquerque Public Schools, NM.

The material in this report was developed primarily as a basis for better planning and allocation of limited resources in a district experiencing a declining enrollment for the foreseeable future. The charts were developed on the basis of historical enrollment information by grade level, and forecasts were based on a standard regression formula…

Building the Business Case for Sustainable Design

ERIC Educational Resources Information Center

Harris, Bill

2011-01-01

While it is too early to measure changes in fall 2011 enrollments, overcrowding on campuses is likely to remain a problem, at least for the foreseeable future. For community colleges, many of which face steep budget cuts in the coming year, the challenge will be how to draw back spending without negatively affecting the student experience.…

A Season of Change: How Science Librarians Can Remain Relevant with Open Access and Scholarly Communications Initiatives

ERIC Educational Resources Information Center

Brown, Elizabeth

2009-01-01

The current rate of change suggests scholarly communications issues such as new publication models and technology to connect library and research tools is expected to continue into the foreseeable future. As models evolve, standards develop, and scientists evolve in their communication patterns, librarians will need to embrace transitional…

Incorporating understanding of informal economic activity in natural resource and economic development policy.

Treesearch

Rebecca J. McLain; Susan J. Alexander; Eric T. Jones

2008-01-01

This report synthesizes the literature on the role of informal economic activity in the United States postindustrial economy. Informal economic activity is expanding in the United States and is likely to continue in the foreseeable future. The formal and informal economic sectors are inextricably intertwined, with individuals and households combining elements of both...

Analysis of the timber situation in Florida, 1995- 2025

Treesearch

Roger C. Conner; Raymond M. Sheffield

2005-01-01

The demand for wood fiber nationwide is expected to increase in the foreseeable future. Harvesting restrictions on forest lands in the West have increased pressure on the South's forest resources to provide more wood. The ability of Florida and other Southern States to respond is uncertain. The authors describe the current extent, condition, and availability of...

Model Program: West Springfield High School, Virginia

ERIC Educational Resources Information Center

Alukonis, J. T.; Settar, Scott

2008-01-01

West Springfield High School sits on the outskirts of Washington, D.C., in Fairfax County, Virginia. WSHS is home to a thriving and growing technology education program. In recent years, the program has exploded from less than 175 students to well over 425. These numbers are expected to continue to grow in the foreseeable future. In 2002, the…

Laser and gas centrifuge enrichment

NASA Astrophysics Data System (ADS)

Heinonen, Olli

2014-05-01

Principles of uranium isotope enrichment using various laser and gas centrifuge techniques are briefly discussed. Examples on production of high enriched uranium are given. Concerns regarding the possibility of using low end technologies to produce weapons grade uranium are explained. Based on current assessments commercial enrichment services are able to cover the global needs of enriched uranium in the foreseeable future.

A Detailed Rubric for Assessing the Quality of Teacher Resource Apps

ERIC Educational Resources Information Center

Cherner, Todd; Lee, Cheng-Yuan; Fegely, Alex; Santaniello, Lauren

2016-01-01

Since the advent of the iPhone and rise of mobile technologies, educational apps represent one of the fastest growing markets, and both the mobile technology and educational app markets are predicted to continue experiencing growth into the foreseeable future. The irony, however, is that even with a booming market for educational apps, very little…

The Future of Work: Insights, Views, Prospects. Basis-Info: Social Policy. IN Press.

ERIC Educational Resources Information Center

Bechtel, Michael

Young people must prepare themselves for lifelong learning and frequent job changes. Optimists predict a new world of work with many creative, interesting, satisfying jobs; pessimists believe society will finally run out of work and foresee unemployment and social downgrading for a majority of people. There are indications at present of both…

Reversal Reversed? The New Consensus on Education and Training

ERIC Educational Resources Information Center

Ainley, Patrick

2015-01-01

England for the foreseeable future is stuck with a one-track government that knows only the crisis measures with which Margaret Thatcher responded to the 1970s crisis of capital accumulation. Deregulation of all public services with privatization of provision on the contracting-out state model is seen as the solution to every problem and is a part…

Creating Examinations for a Linguistically and Culturally Diverse Student Cohort

ERIC Educational Resources Information Center

Hoadley, Susan; Mather, Glyn; Wood, Leigh N.

2012-01-01

Assessments have a significant influence on what and how students learn. While there has been debate as to the merits of examinations as an assessment tool, they will form a major component of assessment in many disciplines for the foreseeable future. To ensure examinations fulfil the dual roles of an assessment tool and motivation for student…

Proceedings of the symposium on fire and watershed management

Treesearch

Neil H. Berg

1989-01-01

Wildfires have affected the landscape since the dawn of time and will continue to do so for the foreseeable future. Policies and practices in response to fire have varied, however, contingent upon a complex mix of values and attitudes overlaid by the technical acumen available to both "fight" the fire and reclaim the land afterwards.

Self-Regulation and Moral Orientation among Finnish and Chinese Adolescents.

ERIC Educational Resources Information Center

Niemi, Hannele; He, Jin

A comparative study of value orientations among Finnish and Chinese adolescents was conducted focusing on how secondary school students in these two cultures understand the purpose and meaningfulness of their lives and the value purposes they foresee in the future. The survey took place in the comprehensive schools of suburban towns in Finland and…

Language and the Department of Defense: Challenges for the 21st Century.

ERIC Educational Resources Information Center

NFLC Policy Issues, 1999

1999-01-01

This interview with Glenn H. Nordin, Assistant Director of Intelligence Policy (Language and Training), Office of the Assistant Secretary of Defense, explores in depth the officially perceived language needs of the U.S. military in the foreseeable future. Questions and answers include the following: How has the end of the Cold War affected…

Developing Employee Assistance Programs: New Roles for School Psychologists.

ERIC Educational Resources Information Center

Allie, Stephen M.

In the spring of 1988 an independent school district in Texas formed a 30-member strategic planning team which gathered data on factors impacting the school district at that time and into the foreseeable future. Planning was facilitated by the appointment of 15 action teams formed to write specific plans to fulfill various targets and strategies.…

FORESEE: Fully Outsourced secuRe gEnome Study basEd on homomorphic Encryption

PubMed Central

2015-01-01

Background The increasing availability of genome data motivates massive research studies in personalized treatment and precision medicine. Public cloud services provide a flexible way to mitigate the storage and computation burden in conducting genome-wide association studies (GWAS). However, data privacy has been widely concerned when sharing the sensitive information in a cloud environment. Methods We presented a novel framework (FORESEE: Fully Outsourced secuRe gEnome Study basEd on homomorphic Encryption) to fully outsource GWAS (i.e., chi-square statistic computation) using homomorphic encryption. The proposed framework enables secure divisions over encrypted data. We introduced two division protocols (i.e., secure errorless division and secure approximation division) with a trade-off between complexity and accuracy in computing chi-square statistics. Results The proposed framework was evaluated for the task of chi-square statistic computation with two case-control datasets from the 2015 iDASH genome privacy protection challenge. Experimental results show that the performance of FORESEE can be significantly improved through algorithmic optimization and parallel computation. Remarkably, the secure approximation division provides significant performance gain, but without missing any significance SNPs in the chi-square association test using the aforementioned datasets. Conclusions Unlike many existing HME based studies, in which final results need to be computed by the data owner due to the lack of the secure division operation, the proposed FORESEE framework support complete outsourcing to the cloud and output the final encrypted chi-square statistics. PMID:26733391

FORESEE: Fully Outsourced secuRe gEnome Study basEd on homomorphic Encryption.

PubMed

Zhang, Yuchen; Dai, Wenrui; Jiang, Xiaoqian; Xiong, Hongkai; Wang, Shuang

2015-01-01

The increasing availability of genome data motivates massive research studies in personalized treatment and precision medicine. Public cloud services provide a flexible way to mitigate the storage and computation burden in conducting genome-wide association studies (GWAS). However, data privacy has been widely concerned when sharing the sensitive information in a cloud environment. We presented a novel framework (FORESEE: Fully Outsourced secuRe gEnome Study basEd on homomorphic Encryption) to fully outsource GWAS (i.e., chi-square statistic computation) using homomorphic encryption. The proposed framework enables secure divisions over encrypted data. We introduced two division protocols (i.e., secure errorless division and secure approximation division) with a trade-off between complexity and accuracy in computing chi-square statistics. The proposed framework was evaluated for the task of chi-square statistic computation with two case-control datasets from the 2015 iDASH genome privacy protection challenge. Experimental results show that the performance of FORESEE can be significantly improved through algorithmic optimization and parallel computation. Remarkably, the secure approximation division provides significant performance gain, but without missing any significance SNPs in the chi-square association test using the aforementioned datasets. Unlike many existing HME based studies, in which final results need to be computed by the data owner due to the lack of the secure division operation, the proposed FORESEE framework support complete outsourcing to the cloud and output the final encrypted chi-square statistics.

Characterization of pituitary cells targeted by antipituitary antibodies in patients with isolated autoimmune diseases without pituitary insufficiency may help to foresee the kind of future hypopituitarism.

PubMed

De Bellis, A; Dello Iacovo, A; Bellastella, G; Savoia, A; Cozzolino, D; Sinisi, A A; Bizzarro, A; Bellastella, A; Giugliano, D

2014-10-01

Detection of antipituitary antibodies (APA) at high levels and with a particular immunofluorescence pattern in patients with autoimmune polyendocrine syndromes may indicate a possible future autoimmune pituitary involvement. This longitudinal study was aimed at characterizing in patients with a single organ-specific autoimmune disease the pituitary cells targeted by APA at start, verifying whether this characterization allows to foresee the kind of possible subsequent hypopituitarism. Thirty-six APA positive and 40 APA negative patients with isolated autoimmune diseases participated in the study. None of them had pituitary dysfunction at entry. Characterization by four-layer immunofluorescence of pituitary cells targeted by APA in APA positive patients at entry and study of pituitary function in all patients were performed every 6 months during a 5 year follow-up. Antipituitary antibodies immunostained selectively one type of pituitary-secreting cells in 21 patients (58.3 %, group 1), and several types of pituitary cells in the remaining 15 (41.7 %, group 2). All patients in group 1 showed subsequently a pituitary insufficiency, corresponding to the type of cells targeted by APA in 18 of them (85.7 %). Only 8 out of 15 patients in group 2 (53.3 %) showed a hypopituitarism, isolated in 7 and combined in the other one. None of APA negative patients showed hypopituitarism. The characterization of pituitary cells targeted by APA in patients with isolated autoimmune diseases, when the pituitary function is still normal, may help to foresee the kind of subsequent hypopituitarism, especially when APA immunostained selectively only one type of pituitary cells. A careful follow-up of pituitary function in these patients is advisable to allow an early diagnosis of hypopituitarism, even in subclinical phase and a consequent timely replacement therapy.

Student Suicide: Could You Be Held Liable?

ERIC Educational Resources Information Center

Taylor, Kelley R.

2001-01-01

Two legal theories inspire suicide-related lawsuits: tort claims of negligence and constitutional claims based on due process. A well-known case illustrates a middle-schooler's suicide and a district's negligence. Liability factors include duty, foreseeability, special relationship, danger creation, and immunity/contributory negligence. (MLH)

Segregating Schools: The Foreseeable Consequences of Tuition Tax Credits.

ERIC Educational Resources Information Center

Yale Law Journal, 1979

1979-01-01

Argues that the effect of a proposed tuition tax credit is school segregation, creating serious constitutional objections under the due process clause. A voucher system would avoid these constitutional objections. Available from the Yale Law Journal, 401A Yale Station, New Haven, CT 06520. (Author/IRT)

Landsat still contributing to environmental research

USGS Publications Warehouse

Loveland, Thomas R.; Cochrane, Mark A.; Henebry, Geoffrey M.

2008-01-01

Landsat data have enabled continuous global monitoring of both human-caused and other land cover disturbances since 1972. Recently degraded performance and intermittent service of the Landsat 7 and Landsat 5 sensors, respectively, have raised concerns about the condition of global Earth observation programs. However, Landsat imagery is still useful for landscape change detection and this capability should continue into the foreseeable future.

Appropriate experimental ecosystem warming methods by ecosystem, objective, and practicality

Treesearch

E.L. Aronson; S.G. McNulty

2009-01-01

The temperature of the Earth is rising, and is highly likely to continue to do so for the foreseeable future. The study of the effects of sustained heating on the ecosystems of the world is necessary so that wemight predict and respond to coming changes on both large and small spatial scales. To this end, ecosystem warming studies have...

Commentary: Study of Gene-Environment Interplay--A Lesson in How to Keep Oneself Busy for the Foreseeable Future

ERIC Educational Resources Information Center

Viding, Essi

2013-01-01

Psychologists and psychiatrists have long been aware that individuals differ in their response to environmental stressors. It is equally apparent that whilst positive or corrective environmental factors help some individuals, others seem to benefit little, if at all. To make the matters even more interesting (at least for a researcher who is…

Intersecting Realities: A Novice's Attempts to Use Critical Literacy to Access Her Students' Figured Worlds

ERIC Educational Resources Information Center

Saunders, Jane M.

2012-01-01

Research suggests that while students in public schools in the U.S. are becoming increasingly diverse in terms of race, ethnicity, class, and culture, the pool of prospective teachers is made up largely of White, middle-class women. The demographic imperative indicates that this trend will remain stable for the foreseeable future, reinforcing the…

Report of the Department of Highways and Transportation on the feasibility and desirability of locally sponsored bus service in northern Virginia to the governor and the General Assembly of Virginia.

DOT National Transportation Integrated Search

1984-01-01

The construction and operation of an integrated mass transportation : system in the Washington Metropolitan Area has proven to be a : difficult task and will continue to be for the foreseeable future. The : administrative and financing structure of W...

Investigating the Linkage between Intrinsic Motivation and Project Team Satisfaction in Undergraduate Agricultural Leadership Students

ERIC Educational Resources Information Center

Lamm, Kevan W.; Carter, Hannah S.; Melendez, Marcus W.

2014-01-01

Organizations have increased the amount of work that is completed by project teams over the past several decades. This trend is projected to continue into the foreseeable future. In response to this trend, the academic community has increased the number of project team based learning experiences for students in classes. The challenge has been that…

Agricultural Change: Consequences for Southern Farms and Rural Communities. Westview Special Studies in Agricultural Science and Policy.

ERIC Educational Resources Information Center

Molnar, Joseph J., Ed.

The 17 articles in this volume are designed to shed light on what farmers are experiencing during the current farm crisis and why. They also examine what current agricultural change means for rural life and rural communities, and what southern farming may be like in the foreseeable future. The articles represent contemporary research and…

Emergency post-fire rehabilitation treatment effects on burned area ecology and long-term restoration

Treesearch

Peter R. Robichaud; Sarah A. Lewis; Robert E. Brown; Louise E. Ashmun

2009-01-01

The predicted continuation of strong drying and warming trends in the southwestern United States underlies the associated prediction of increased frequency, area, and severity of wildfires in the coming years. As a result, the management of wildfires and fire effects on public lands will continue to be a major land management priority for the foreseeable future....

Voices - Like nurses, education must adapt to changes in care, says Janet Finch.

PubMed

Finch, Dame Janet

2015-03-18

Nurses and midwives will play a vital role in meeting the health challenges of the future. While it is impossible to foresee all the ways in which practice will change over the next decade, we do know that nurses and midwives will be working with an ageing population, with more community-based services and growing public expectations.

Simulated climate effects of land degradation near Urumqi, China

NASA Astrophysics Data System (ADS)

Moore, N. J.; Qi, J.

2009-12-01

Western China's drylands, particularly around Urumqi city in Xinjiang Autonomous Region are changing due to increased grazing pressures, urban growth, and increasing population. These changes, driven by national policies of openness and economic development, are expected to continue for the foreseeable future. The continued degradation of rangelands surrounding Urumqi can impact not only socioeconomic characteristics but also regional climate patterns. Here we show results from high-resolution regional climate simulations of the Urumqi area using the RAMS regional climate model. Under differing levels of rangeland degradation, from no degradation in vegetative cover and leaf area index (LAI) to 75% reduction a variety of impacts are found in the region. We examined the impacts of these changes in land cover properties via current rangeland management practices, including influences on summertime rainfall (important for grassland production) and year-round wind patterns, which are two major natural factors related to the air pollution and water scarcity of the city.

Excreta Sampling as an Alternative to In Vivo Measurements at the Hanford Site.

PubMed

Carbaugh, Eugene H; Antonio, Cheryl L; Lynch, Timothy P

2015-08-01

The capabilities of indirect radiobioassay by urine and fecal sample analysis were compared with the direct radiobioassay methods of whole body counting and lung counting for the most common radionuclides and inhalation exposure scenarios encountered by Hanford workers. Radionuclides addressed by in vivo measurement included 137Cs, 60Co, 154Eu, and 241Am as an indicator for plutonium mixtures. The same radionuclides were addressed using gamma energy analysis of urine samples, augmented by radiochemistry and alpha spectrometry methods for plutonium in urine and fecal samples. It was concluded that in vivo whole body counting and lung counting capability should be maintained at the Hanford Site for the foreseeable future, however, urine and fecal sample analysis could provide adequate, though degraded, monitoring capability for workers as a short-term alternative, should in vivo capability be lost due to planned or unplanned circumstances.

Assessing driver's mental representation of Adaptive Cruise Control (ACC) and its possible effects on behavioural adaptations.

PubMed

Piccinini, Giulio Francesco; Simões, Anabela; Rodrigues, Carlos Manuel; Leitão, Miguel

2012-01-01

The introduction of Adaptive Cruise Control (ACC) could be very helpful for making the longitudinal driving task more comfortable for the drivers and, as a consequence, it could have a global beneficial effect on road safety. However, before or during the usage of the device, due to several reasons, drivers might generate in their mind incomplete or flawed mental representations about the fundamental operation principles of ACC; hence, the resulting usage of the device might be improper, negatively affecting the human-machine interaction and cooperation and, in some cases, leading to negative behavioural adaptations to the system that might neutralise the desirable positive effects on road safety. Within this context, this paper will introduce the methodology which has been developed in order to analyse in detail the topic and foresee, in the future, adequate actions for the recovery of inaccurate mental representations of the system.

EMF Monitoring—Concepts, Activities, Gaps and Options

PubMed Central

Dürrenberger, Gregor; Fröhlich, Jürg; Röösli, Martin; Mattsson, Mats-Olof

2014-01-01

Exposure to electromagnetic fields (EMF) is a cause of concern for many people. The topic will likely remain for the foreseeable future on the scientific and political agenda, since emissions continue to change in characteristics and levels due to new infrastructure deployments, smart environments and novel wireless devices. Until now, systematic and coordinated efforts to monitor EMF exposure are rare. Furthermore, virtually nothing is known about personal exposure levels. This lack of knowledge is detrimental for any evidence-based risk, exposure and health policy, management and communication. The main objective of the paper is to review the current state of EMF exposure monitoring activities in Europe, to comment on the scientific challenges and deficiencies, and to describe appropriate strategies and tools for EMF exposure assessment and monitoring to be used to support epidemiological health research and to help policy makers, administrators, industry and consumer representatives to base their decisions and communication activities on facts and data. PMID:25216256

Experimental gravitation in space - Is there a future?

NASA Astrophysics Data System (ADS)

Wharton, R. A.; McKay, C. P.; Mancinelli, R. L.; Simmons, G. M.

Experimental gravitation enters the 1990s with a past full of successes, but with a future full of uncertainties. Intellectually, the field is as vigorous as ever, with major thrusts in three main areas: the search for gravitational radiation, the study of post and post-post Newtonian effects, and the detection of hypothetical feeble new interactions. It is the only branch of space research involved in fundamental physics. But politically and financially, the future is uncertain. Competition for funding and for flight opportunities will be stiff for the foreseeable future, both with other disciplines such as astrophysics, planetary science and the military, and within experimental gravitation itself. Difficult choices lie ahead. This paper reviews the current state of the field and attempts to peer into the future.

Understanding Tort Liability and Its Relationship to Extension Professionals.

ERIC Educational Resources Information Center

Long, Norman D.; And Others

This study focuses on tort liability and its relationship to extension professionals working with 4-H programs. Tort liability as related to extension professionals consists of ten components: due care, physical defects (inspection of premises), instruction and supervision, first aid and medical treatment, foreseeability, causation, defamation,…

Technological challenges for boosting coal production with environmental sustainability.

PubMed

Ghose, Mrinal K

2009-07-01

The global energy requirement has grown at a phenomenon rate and the consumption of primary energy sources has been a very high positive growth. This paper focuses on the consumption of different primary energy sources and it identifies that coal will continue to remain as the prime energy source in foreseeable future. It examines the energy requirement perspective for India and demand of coal as the prime energy source. Economic development and poverty alleviation depend on securing affordable energy sources and Indian coal mining industry offers a bright future for the country's energy security, provided the industry is allowed to develop by supportive government policies and adopts latest technologies for mining. It is an irony that in-spite of having a plentiful reserves, India is not able to jack up coal production to meet its current and future demand. It discusses the strategies to be adopted for growth and meeting the coal demand. But such energy are very much concerned with environmental degradation and must be driven by contemporary managerial acumen addressing environmental and social challenges effectively The paper highlights the emissions of greenhouse gases due to burning of fossil fuels and environmental consequences of global warming and sea-level rise. Technological solutions for environment friendly coal mining and environmental laws for the abatement of environmental degradation are discussed in this paper.

Perspectives on Russian Foreign Policy

DTIC Science & Technology

2012-09-01

defense spending and in- creasingly military cast of the rivalry with America is a warning sign in this regard. For if the end result of Putinism... for building a missile defense system, which is seen as a means to render the whole system of nuclear checks and balances irrelevant. The main...comparative advantages, at least for the foreseeable future , are oil and gas and its nuclear weapons,

Disruption of the ‘disease triangle’ by chemical and physical environmental change

Treesearch

A. H. Chappelka; N. E. Grulke; L. De Kok

2015-01-01

The physical and chemical environment of the Earth has changed rapidly over the last 100 years and is predicted to continue to change into the foreseeable future. One of the main concerns with potential alterations in climate is the propensity for increases in the magnitude and frequency of extremes to occur. Even though precipitation is predicted to increase in some...

Al Qaeda and the Global War on Terror

DTIC Science & Technology

2010-01-01

publishers throughout the foreseeable future, as will titillating inside stories of headline-making personalities such as Clinton, Bush, Rumsfeld...the top of Islam’s bottle of fat -free milk.98 Since his early twenties, bin Laden has exemplified the pious warrior, first pitted against the...1 Bruce Hoffman, Inside Terrorism (New York: Columbia University Press, 2006), 2-3, 16. According to Bruce Hoffman, a

Strained Schools Face Bleak Future: Districts Foresee Budget Cuts, Teacher Layoffs, and a Slowing of Education Reform Efforts

ERIC Educational Resources Information Center

Kober, Nancy; Rentner, Diane Stark

2011-01-01

Many school districts had to cope with shrinking budgets this past school year, but the effects of these cuts were cushioned to some extent by the availability of federal economic stimulus money. In 2009 and 2010, school districts received about $80 billion from the American Recovery and Reinvestment Act of 2009 (ARRA). These funds were intended…

"Your Pronunciation and Your Accent is Very Excellent": Orientations of Identity during Compliment Sequences in English as a Lingua Franca Encounters

ERIC Educational Resources Information Center

Jenks, Christopher

2013-01-01

The widespread use of English has--for better or worse--shaped the social and communicative norms and practices of many people the world over, and the likelihood of this continuing for the foreseeable future raises questions concerning English ownership, linguistic imperialism, language attrition, and mutual intelligibility, to name a few. These…

Capital Promises: Why NYC Children Don't Have the School Buildings They Need

ERIC Educational Resources Information Center

Connell, Noreen

2007-01-01

The objective of this report is to answer the big questions about whether in the foreseeable future most school overcrowding in New York City will be eliminated and all city children will have class sizes and access to school libraries, science labs, art/music rooms, and physical fitness activities that are the norm for students in the rest of the…

Moving Forward by Looking in the Rearview Mirror

DTIC Science & Technology

2016-06-01

the foreseeable future.1 As senior civilian and military leaders acknowledge that conventional military superiority does not guarantee victory in...charismatic, or rational legal. Traditional legitimacy refers to the respect afforded to traditional authorities, including tribal leaders such as those...found in southwest Asia and the Middle East.10 Charismatic legitimacy is linked to a specific person or ideology, often a religious leader . Rational

Electronic Warfare: Rethinking the Importance of Its Role In Military Operations

DTIC Science & Technology

2016-06-10

characterized by misperception, misunderstanding, and mismanagement, resulting in EW being devalued and its resources misused. This thesis will argue how...structure, advocacy, and strategy. Devalued and lacking advocacy, EW fails to earn resource investment today and into the foreseeable future. The...of Defense. This thesis is entirely my own work except as documented in footnotes. (or appropriate statement per the Academic Integrity Policy

Environmental Assessment Construction of New Child Development Center at Tinker Air Force Base, Oklahoma

DTIC Science & Technology

2010-03-22

formaldehyde, acetaldehyde, methanol and other HAP from lean bum engines (Included in Addendum F). TABLE 2 Cogeneration Emission Factors ...material which includes recycling of material where feasible. Local landfills have the capacity to accept the amount of waste generated. The contractor...past, present, and reasonably foreseeable future actions. Cumulative impacts can result from individually minor but collectively significant factors

Methods used for analyzing the cumulative watershed effects of fuel management on sediment in the Eastern United States

Treesearch

Daniel A. Marion; J. Alan Clingenpeel

2012-01-01

Previous chapters have described how various resource systems within a watershed can experience cumulative effects from fuel management activities like prescribed burning. As noted before, a cumulative effect is “the impact on the environment which results from the incremental impact of the action when added to other past, present, and reasonably foreseeable future...

Robots, multi-user virtual environments and healthcare: synergies for future directions.

PubMed

Moon, Ajung; Grajales, Francisco J; Van der Loos, H F Machiel

2011-01-01

The adoption of technology in healthcare over the last twenty years has steadily increased, particularly as it relates to medical robotics and Multi-User Virtual Environments (MUVEs) such as Second Life. Both disciplines have been shown to improve the quality of care and have evolved, for the most part, in isolation from each other. In this paper, we present four synergies between medical robotics and MUVEs that have the potential to decrease resource utilization and improve the quality of healthcare delivery. We conclude with some foreseeable barriers and future research directions for researchers in these fields.

Translocation as a Conservation Tool for Restoring Insular Avifauna

DTIC Science & Technology

2011-11-01

5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of Missouri, Fisheries and Wildlife, Suite...within the foreseeable future. One approach to conservation includes establishing new communities of threatened species on islands where they did not...4A C-86 TRANSLOCATION AS A CONSERVATION TOOL FOR INSULAR AVIFAUNA DR. DYLAN KESLER University of Missouri Fisheries and Wildlife, Suite

Glycosylated haemoglobin: measurement and clinical use.

PubMed

Peacock, I

1984-08-01

The discovery, biochemistry, laboratory determination, and clinical application of glycosylated haemoglobins are reviewed. Sources of error are discussed in detail. No single assay method is suitable for all purposes, and in the foreseeable future generally acceptable standards and reference ranges are unlikely to be agreed. Each laboratory must establish its own. Nevertheless, the development of glycosylated haemoglobin assays is an important advance. They offer the best available means of assessing diabetic control.

The Jasmine Revolution: Applied Lessons for U.S. Grand Strategy

DTIC Science & Technology

2017-04-06

AIR WAR COLLEGE AIR UNIVERSITY THE JASMINE REVOLUTION APPLIED LESSONS FOR U.S. GRAND STRATEGY by Brandon K. Beightol...period that has come to be known as the Arab Spring. It all began with the Jasmine revolution, named for the Tunisian official flower, in which...can be used to understand and possibly foresee future occurrences. Factors leading up to the Jasmine Revolution In 1956, Habib Bourguiba took

National Waterways Study: Findings and Conclusions (from Contractor Study Effort).

DTIC Science & Technology

1982-05-01

basic process by which decisions are made by the Congress on the allocation of investments in the navigation system and the levels of funding for...waterways structures anticipates no significant change in the basic navigation technology in the foreseeable future* However, better management of the...other products discussed in this section. " As a result, water transportation handles only about one quarter of all basic and intermediate industrial

The Changing Nature of the Academic Deanship. ASHE-ERIC Higher Education Report, Volume 28, Number 1. Jossey-Bass Higher and Adult Education Series.

ERIC Educational Resources Information Center

Wolverton, Mimi; Gmelch, Walter H.; Montez, Joni; Nies, Charles T.

This monograph provides a compilation of scholarly literature written about academic deans. The premise on which it rests suggests that changes external to the academy have affected the nature of the academic deanship and will continue to affect it for the foreseeable future. The book considers four questions about the academic deanship. The first…

Civilization’s Drying Cradle: Water Politics in the Tigris-Euphrates River Basin

DTIC Science & Technology

2012-03-22

pollution will ensure that water disputes increasingly shape Middle East politics for the foreseeable future. Exacerbating the water supply problem is...tolls in water withdrawals, damaged land, and polluted watersheds. One hectare of irrigated land requires an average of 12,000 m3 water annually.21...communities are forced to use polluted runoff from upstream irrigation projects, already highly saline and contaminated with herbicides. Soil salinization

Now Hunt's back in the job, here's the top issues he needs to address.

PubMed

2016-07-20

Jeremy Hunt is back in his office at Richmond House, home of the Department of Health in London, for the foreseeable future - and against expectations. Even he must have thought that his time was up. Attention will now focus on what he should do next given his new lease of life, so here's what Nursing Standard would like him to tackle first.

Chang'e 3 lunar mission and upper limit on stochastic background of gravitational wave around the 0.01 Hz band

NASA Astrophysics Data System (ADS)

Tang, Wenlin; Xu, Peng; Hu, Songjie; Cao, Jianfeng; Dong, Peng; Bu, Yanlong; Chen, Lue; Han, Songtao; Gong, Xuefei; Li, Wenxiao; Ping, Jinsong; Lau, Yun-Kau; Tang, Geshi

2017-09-01

The Doppler tracking data of the Chang'e 3 lunar mission is used to constrain the stochastic background of gravitational wave in cosmology within the 1 mHz to 0.05 Hz frequency band. Our result improves on the upper bound on the energy density of the stochastic background of gravitational wave in the 0.02-0.05 Hz band obtained by the Apollo missions, with the improvement reaching almost one order of magnitude at around 0.05 Hz. Detailed noise analysis of the Doppler tracking data is also presented, with the prospect that these noise sources will be mitigated in future Chinese deep space missions. A feasibility study is also undertaken to understand the scientific capability of the Chang'e 4 mission, due to be launched in 2018, in relation to the stochastic gravitational wave background around 0.01 Hz. The study indicates that the upper bound on the energy density may be further improved by another order of magnitude from the Chang'e 3 mission, which will fill the gap in the frequency band from 0.02 Hz to 0.1 Hz in the foreseeable future.

29 CFR 825.304 - Employee failure to provide notice.

Code of Federal Regulations, 2014 CFR

2014-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act... onset of an employee's FMLA leave to be delayed due to lack of required notice, it must be clear that... distribution, as required by § 825.300. (b) Foreseeable leave—30 days. When the need for FMLA leave is...

29 CFR 825.304 - Employee failure to provide notice.

Code of Federal Regulations, 2013 CFR

2013-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act... onset of an employee's FMLA leave to be delayed due to lack of required notice, it must be clear that... distribution, as required by § 825.300. (b) Foreseeable leave—30 days. When the need for FMLA leave is...

29 CFR 825.304 - Employee failure to provide notice.

Code of Federal Regulations, 2011 CFR

2011-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act... onset of an employee's FMLA leave to be delayed due to lack of required notice, it must be clear that... distribution, as required by § 825.300. (b) Foreseeable leave—30 days. When the need for FMLA leave is...

29 CFR 825.304 - Employee failure to provide notice.

Code of Federal Regulations, 2012 CFR

2012-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act... onset of an employee's FMLA leave to be delayed due to lack of required notice, it must be clear that... distribution, as required by § 825.300. (b) Foreseeable leave—30 days. When the need for FMLA leave is...

When microchip implants do more than drug delivery: blending, blurring, and bundling of protected health information and patient monitoring.

PubMed

Bramstedt, Katrina A

2005-01-01

Although currently in the research stage, scientists argue that drug-releasing microchip implants are on the horizon for future patients. This paper presents ethical reflection on these implants and identifies specific areas of concern; namely, patient monitoring and tracking, and patient privacy and confidentiality. It is foreseeable that drug delivery chips could be multifunctional with the overt or covert addition of sensors that monitor more than just the bloodstream concentrations of prescribed drugs (e.g., cotinine and alcohol in non-compliant patients, patient location via radio frequency or global positioning satellite). Similarly, it is foreseeable that these chips could be embedded with a patient's protected health information that could potentially be accessed and used by unauthorized persons. While drug delivery microchips are theoretically convenient and accurate for dosing, and might offer faster drug delivery with fewer side effects, ethical issues loom and should be contemplated now, while the technology is still under development.

Editorial overview: Molecular and genetic bases of disease: the double life of DNA.

PubMed

McMurray, Cynthia T; Vijg, Jan

2014-06-01

This issue of Current Opinions focuses on the dual role of DNA in life and death. In ancient Roman religion and myth, Janus is the god who looks both to the past and to the future. He guides the beginnings of life, its progression from one condition to another, and he foresees distant events. The analogy to DNA could not be stronger. Closely interacting with the environment, our basic genetics provides the origin of life, guides the quality of health with age, predicts disease, and ultimately foresees our end. A shared and deep interest with the origin of life has long prompted our desire to define aging, and, ultimately, to understand whether it can be reversed. In this special issue, the authors collectively review concepts of normative aging, DNA instability, DNA repair, the genetic contribution of age and diet to disease, and how the basic molecular transactions of DNA guide both the transitions to life as well as the transitions to death. Published by Elsevier Ltd.

The double life of DNA

PubMed Central

McMurray, Cynthia T.; Vijg, Jan

2015-01-01

This issue of Current Opinions focuses on the dual role of DNA in life and death. In ancient Roman religion and myth, Janus is the god who looks both to the past and to the future. He guides the beginnings of life, its progression from one condition to another, and he foresees distant events. The analogy to DNA could not be stronger. Closely interacting with the environment, our basic genetics provides the origin of life, guides the quality of health with age, predicts disease, and ultimately foresees our end. A shared and deep interest in the origin of life has long prompted our desire to define aging, and, ultimately, to understand whether it can be reversed. In this special issue, the authors collectively review concepts of normative aging, DNA instability, DNA repair, the genetic contribution of age and diet to disease, and how the basic molecular transactions of DNA give it a double life that guides health and survival, as well as the transitions to death. PMID:25282314

Report on Progress Toward Security and Stability in Afghanistan: United States Plan for Sustaining the Afghanistan National Security Forces

DTIC Science & Technology

2012-04-01

and Section 1230 of the National Defense Authorization Act for Fiscal...has personally taken ownership of anti-corruption reforms within the Ministry of Defense and is fighting to make the MoD an example for the rest of...progress, the ANA is expected to lack combat enablers and logistics support for the foreseeable future . AFGHAN AIR FORCE The Afghan Air Force’s

Airpower in Hybrid War: Ethical Implications for the Joint Force Commander

DTIC Science & Technology

2014-05-15

waging war) aspect of just war theory . 13 In light of the issue, the spirit of US acquisition is one that historically and presently puts...by the NWC or the Department of the Navy. 14. ABSTRACT In the foreseeable future, the United States ( US ) will likely find itself engaged in hybrid...behaviors. Moreover, political risk aversion, coupled with the perceived “sanitary” use of technologically advanced weapons systems, makes US airpower

Lockheed Martin Missiles and Fire Control’s (MFC) Ascent to Greatness: Perspectives of a SECDEF Fellow

DTIC Science & Technology

2008-04-01

and has approximately 2,000 courses available. This collaborative and exceedingly effective learning environment is supported by ancillary tools and...responsive subject-matter-experts to help leaders and employees grow and become more effective . MFC has six leadership development programs commensurate...concept; hence, keeping the company viable and strong for the foreseeable future, by sticking to its core and not chasing fads or jumping on

A critical review of financial measures as reported in the Ontario hospital balanced scorecard.

PubMed

Parkinson, John; Tsasis, Peter; Porporato, Marcela

2007-01-01

For Ontario hospitals in Canada, the Financial Performance and Condition measures in the Ontario hospital balanced scorecard are especially of interest since in the foreseeable future, they may be linked to provincial government funding decisions. However, we find that these measures lack valuable information on key attributes that affect organizational performance. We suggest changes that focus on key drivers of performance and reflect the operational realities of Ontario hospitals.

In Harmony with the Population: Ethnomusicology as a Framework for Countering Violent Extremism in the Sahel

DTIC Science & Technology

2016-12-01

digital media , art, multiculturalism, communication flow theory 15. NUMBER OF PAGES 143 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT...and Chad as a Case Study,” 59. 41 methods), and mass communication ( communication to a large audience via mass media ).91 According to a 2007...proliferation of digital technology for at least the foreseeable future. Early communication theorists considered mass- media communication flow to be a

Vinculos Entre la Capacitacion de Docentes y el Desarrollo de Materiales Educativos Impresos--Anotaciones para Una Discusion (Links between In-service Teacher Training and the Development of Printed Educational Aids).

ERIC Educational Resources Information Center

Valle, Victor M.

Textbooks and other printed materials will be ever present, in the foreseeable future, as major aids for teaching and learning processes. New textbooks imply new guidelines for teachers, and the ways to handle such guidelines demand teacher training. This paper explains some links between inservice teacher training programs and the development of…

Ergonomics Contribution in Maintainability

NASA Astrophysics Data System (ADS)

Teymourian, Kiumars; Seneviratne, Dammika; Galar, Diego

2017-09-01

The objective of this paper is to describe an ergonomics contribution in maintainability. The economical designs, inputs and training helps to increase the maintainability indicators for industrial devices. This analysis can be helpful, among other cases, to compare systems, to achieve a better design regarding maintainability requirements, to improve this maintainability under specific industrial environment and to foresee maintainability problems due to eventual changes in a device operation conditions. With this purpose, this work first introduces the notion of ergonomics and human factors, maintainability and the implementation of assessment of human postures, including some important postures to perform maintenance activities. A simulation approach is used to identify the critical posture of the maintenance personnel and implements the defined postures with minimal loads on the personnel who use the equipment in a practical scenario. The simulation inputs are given to the designers to improve the workplace/equipment in order to high level of maintainability. Finally, the work concludes summarizing the more significant aspects and suggesting future research.

A Fast Solution to NGS Library Prep with Low Nanogram DNA Input

PubMed Central

Liu, Pingfang; Lohman, Gregory J.S.; Cantor, Eric; Langhorst, Bradley W.; Yigit, Erbay; Apone, Lynne M.; Munafo, Daniela B.; Stewart, Fiona J.; Evans, Thomas C.; Nichols, Nicole; Dimalanta, Eileen T.; Davis, Theodore B.; Sumner, Christine

2013-01-01

Next Generation Sequencing (NGS) has significantly impacted human genetics, enabling a comprehensive characterization of the human genome as well as a better understanding of many genomic abnormalities. By delivering massive DNA sequences at unprecedented speed and cost, NGS promises to make personalized medicine a reality in the foreseeable future. To date, library construction with clinical samples has been a challenge, primarily due to the limited quantities of sample DNA available. Our objective here was to overcome this challenge by developing NEBNext® Ultra DNA Library Prep Kit, a fast library preparation method. Specifically, we streamlined the workflow utilizing novel NEBNext reagents and adaptors, including a new DNA polymerase that has been optimized to minimize GC bias. As a result of this work, we have developed a simple method for library construction from an amount of DNA as low as 5 ng, which can be used for both intact and fragmented DNA. Moreover, the workflow is compatible with multiple NGS platforms.

Stratospheric ozone depletion due to nitrous oxide: influences of other gases

PubMed Central

Portmann, R. W.; Daniel, J. S.; Ravishankara, A. R.

2012-01-01

The effects of anthropogenic emissions of nitrous oxide (N2O), carbon dioxide (CO2), methane (CH4) and the halocarbons on stratospheric ozone (O3) over the twentieth and twenty-first centuries are isolated using a chemical model of the stratosphere. The future evolution of ozone will depend on each of these gases, with N2O and CO2 probably playing the dominant roles as halocarbons return towards pre-industrial levels. There are nonlinear interactions between these gases that preclude unambiguously separating their effect on ozone. For example, the CH4 increase during the twentieth century reduced the ozone losses owing to halocarbon increases, and the N2O chemical destruction of O3 is buffered by CO2 thermal effects in the middle stratosphere (by approx. 20% for the IPCC A1B/WMO A1 scenario over the time period 1900–2100). Nonetheless, N2O is expected to continue to be the largest anthropogenic emission of an O3-destroying compound in the foreseeable future. Reductions in anthropogenic N2O emissions provide a larger opportunity for reduction in future O3 depletion than any of the remaining uncontrolled halocarbon emissions. It is also shown that 1980 levels of O3 were affected by halocarbons, N2O, CO2 and CH4, and thus may not be a good choice of a benchmark of O3 recovery. PMID:22451111

The future of anticoagulation clinics.

PubMed

Macik, B Gail

2003-01-01

Anticoagulation therapy is the foundation of treatment for thromboembolic disorders; and coumarin derivatives (warfarin in the United States) are the only orally administered anticoagulant medications currently available. Due to the expense and relative difficulties associated with this route of administration, parenteral drugs are not used routinely for long-term therapy, leaving warfarin as the anticoagulant of choice in the outpatient setting. The management of warfarin is problematic, however, due the nuances of its pharmacodynamic and pharmacokinetic profile and the requirement for frequent monitoring of blood levels. Although management by anticoagulation clinics is considered the gold standard for warfarin therapy, management by an anticoagulation clinic may not be the optimal option from a clinician's view and, in many cases, may not be an option at all. Anticoagulation clinics may impinge on the doctor-patient relationship. Difficulties of communication and reimbursement are not ameliorated by a specialty clinic. Innovations in warfarin management, including patient self-management and computerized dosing programs, are alternatives for improved care that are available with or without input by an anticoagulation service. New oral drugs on the horizon do not require the same intensity of monitoring and do not present the same pharmacodynamic problems associated with warfarin. Warfarin will become obsolete in the foreseeable future. If anticoagulation clinics continue, they must re-define their role as the major part of the workload, warfarin management, disappears. To adapt, clinics must strengthen and enhance their role as coordinators and educators, and less so, managers of anticoagulation therapy.

A Closed Form Solution for an Unorthodox Trigonometric Integral

ERIC Educational Resources Information Center

Wu, Yan

2009-01-01

A closed form solution for the trigonometric integral [integral]sec[superscript 2k+1]xdx, k=0,1,2,..., is presented in this article. The result will fill the gap in another trigonometric integral [integral]sec[superscript 2m+1] x tan[superscript 2n]xdx, which is neglected by most of the calculus textbooks due to its foreseeable unorthodox solution…

The Matter Simulation (R)evolution

PubMed Central

2018-01-01

To date, the program for the development of methods and models for atomistic and continuum simulation directed toward chemicals and materials has reached an incredible degree of sophistication and maturity. Currently, one can witness an increasingly rapid emergence of advances in computing, artificial intelligence, and robotics. This drives us to consider the future of computer simulation of matter from the molecular to the human length and time scales in a radical way that deliberately dares to go beyond the foreseeable next steps in any given discipline. This perspective article presents a view on this future development that we believe is likely to become a reality during our lifetime. PMID:29532014

Some Future Software Engineering Opportunities and Challenges

NASA Astrophysics Data System (ADS)

Boehm, Barry

This paper provides an update and extension of a 2006 paper, “Some Future Trends and Implications for Systems and Software Engineering Processes,” Systems Engineering, Spring 2006. Some of its challenges and opportunities are similar, such as the need to simultaneously achieve high levels of both agility and assurance. Others have emerged as increasingly important, such as the challenges of dealing with ultralarge volumes of data, with multicore chips, and with software as a service. The paper is organized around eight relatively surprise-free trends and two “wild cards” whose trends and implications are harder to foresee. The eight surprise-free trends are:

Impact of the resistive wall impedance on beam dynamics in the Future Circular e+e- Collider

NASA Astrophysics Data System (ADS)

Migliorati, M.; Belli, E.; Zobov, M.

2018-04-01

The Future Circular Collider study, which aims at designing post-LHC particle accelerator options, is entering in the final stage, which foresees a conceptual design report containing the basic requirements for a hadron and a lepton collider, as well as options for an electron-proton machine. Due to the high beam intensities of these accelerators, collective effects have to be carefully analyzed. Among them, the finite conductivity of the beam vacuum chamber represents a major source of impedance for the electron-positron collider. By using numerical and analytical tools, a parametric study of longitudinal and transverse instabilities caused by the resistive wall is performed in this paper for the case of the Future Circular Collider lepton machine, by taking into account also the effects of coating, used to fight the electron cloud build up. It will be proved that under certain assumptions the coupling impedance of a two layer system does not depend on the conductivity of the coating and this property represents an important characteristic for the choice of the material itself. The results and findings of this study have an impact on the machine design in several aspects. In particular the quite low threshold of single bunch instabilities with respect to the nominal beam current and the not negligible power losses due to the resistive wall are shown, together with the necessity of a new feedback system to counteract the fast transverse coupled bunch instability. The importance of a round vacuum chamber to avoid the quadrupolar tune shift is also discussed. Finally the crucial importance of the beam pipe material coating and thickness choice for the above results is underlined.

Evaluating the Combined UUV Efforts in a Large-Scale Mine Warfare Environment

DTIC Science & Technology

2015-03-01

buddy, COL Fred Lough and Mary Mullin, for being loving and support parents-in-law, and Linda and Harry Thompson, for being the most devoted and...completed in 2015. Until the RMMV and AQS-20B issues are resolved, the RMS operational test cannot be completed onboard LCS ( Seligman , 2015). These poor...available in the foreseeable future. Therefore, the Avenger-Class ships will remain the main MCM platform ( Seligman , 2014). The Avenger-Class ships are

Snakes in the wrong places: Gordon Rodda’s career in invasive species research

USGS Publications Warehouse

Wilson, Jim

2012-01-01

When USGS research zoologist Gordon G. Rodda was a graduate student at Cornell University studying behavioral biology of alligators —or later, completing a post-doc at the Smithsonian Institute studying the social behavior of green iguanas in Venezuela or following that, as a statistics and sociobiology instructor at the University of Tennessee—he did not foresee that his professional future was in snakes. Lots of snakes, and in places they don’t belong.

Orbital Spacecraft Consumables Resupply System (OSCRS). Volume 2: Study results

NASA Technical Reports Server (NTRS)

1987-01-01

The objective was to establish an earth storable fluids tanker concept which satisfies the initial resupply requirements for the Gamma Ray Observatory (GRO) for reasonable front end (design, development, verification) cost while providing growth potential for foreseeable future earth storable resupply mission requirements. The achievement of these objectives becomes possible with the development of a modularized tanker concept which is a hybrid of a dedicated GRO tanker and a generic earth storable propellant tanker.

Environmental Assessment: Construct Fire Station at Grand Forks Air Force Base

DTIC Science & Technology

2006-03-01

foreseeable future actions regardless of what agency or person undertakes such other actions” (40 CFR §1508.7). Cumulative effects are likely to arise when...dining, relaxing, and physical fitness . 4 .2 Need for the Action ( why this action is desired or required- why here, why now) : The 1957-vintage main...Army permit would not be required . If you disagree with this jurisdictional determination, you have the right to appeal the decision . If you would like

Is the Current US Navy Pacific Basing Structure Adequate for the Twenty-First Century?

DTIC Science & Technology

2006-12-15

events. The Threat (To Deter, To Defeat, To Maintain the Peace) Chinese Grand Strategy and Maritime Power by Thomas M. Kane ; “China’s Quest for...Congress” by Ronald O’Rourke provide the initial basis for assessment of the potential threat posed by China’s naval buildup. Kane discussed that...cooperation among the ANZUS allies will continue for the foreseeable future. Conclusion There is a significant body of literature covering the history of

On the Retirement of E.P. Goldfinch, Founder of Radiation Protection Dosimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, Joseph C.; Horowitz, Yigal S.

This special issue of Radiation Protection Dosimetry commemorates the many years of service Eddie has dedicated to the international radiation protection community. Beginning with its first issue in 1981, Eddie led RPD to its current prominence with a guiding hand and Solomon-like wisdom, coupled with keen common sense which will be sorely missed. But, there is no doubt that the journal he created will continue to flourish in the foreseeable future.

QIPP: cutting budgets or working smarter?

PubMed

Brocklehurst, P; Jones, C; Tickle, M

2011-04-23

The Department of Health's response to the national budget deficit is to ensure that the provision of NHS services is guided by four fundamental 'QIPP' principles: Quality, Innovation, Prevention, and Productivity. This agenda will govern all aspects of the National Health Service's (NHS') health care provision for the foreseeable future. NHS dental services will, like all other NHS services, need to make a contribution to the QIPP agenda. The purpose of this paper is to outline the implications for NHS dentistry.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ghose, M.K.; Paul, B.

The global energy requirement has grown at a phenomenal rate and the consumption of primary energy sources has been a very high positive growth. This article focuses on the consumption of different primary energy sources and it identifies that coal will continue to remain as the prime energy in the foreseeable future. It examines energy requirement perspectives for India and demands of petroleum, natural gas, and coal bed methane in the foreseeable future. It discusses the state of present day petroleum and petrochemical industries in the country and the latest advances in them to take over in the next fewmore » years. The regional pattern of consumption of primary energy sources shows that oil remains as the largest single source of primary energy in most parts of the world. However, gas dominates as the prime source in some parts of the world. Economic development and poverty alleviation depend on securing affordable energy sources and for the country's energy security; it is necessary to adopt the latest technological advances in petroleum and petrochemical industries by supportive government policies. But such energy is very much concerned with environmental degradation and must be driven by contemporary managerial acumen addressing environmental and social challenges effectively. Environmental laws for the abatement of environmental degradation are discussed in this paper. The paper concludes that energy security leading to energy independence is certainly possible and can be achieved through a planned manner.« less

FORESEE™ User-Centric Energy Automation

DOE Office of Scientific and Technical Information (OSTI.GOV)

FORESEE™ is a home energy management system (HEMS) that provides a user centric energy automation solution for residential building occupants. Built upon advanced control and machine learning algorithms, FORESEE intelligently manages the home appliances and distributed energy resources (DERs) such as photovoltaics and battery storage in a home. Unlike existing HEMS in the market, FORESEE provides a tailored home automation solution for individual occupants by learning and adapting to their preferences on cost, comfort, convenience and carbon. FORESEE improves not only the energy efficiency of the home but also its capability to provide grid services such as demand response. Highlymore » reliable demand response services are likely to be incentivized by utility companies, making FORESEE economically viable for most homes.« less

Future hadron colliders: From physics perspectives to technology R&D

NASA Astrophysics Data System (ADS)

Barletta, William; Battaglia, Marco; Klute, Markus; Mangano, Michelangelo; Prestemon, Soren; Rossi, Lucio; Skands, Peter

2014-11-01

High energy hadron colliders have been instrumental to discoveries in particle physics at the energy frontier and their role as discovery machines will remain unchallenged for the foreseeable future. The full exploitation of the LHC is now the highest priority of the energy frontier collider program. This includes the high luminosity LHC project which is made possible by a successful technology-readiness program for Nb3Sn superconductor and magnet engineering based on long-term high-field magnet R&D programs. These programs open the path towards collisions with luminosity of 5×1034 cm-2 s-1 and represents the foundation to consider future proton colliders of higher energies. This paper discusses physics requirements, experimental conditions, technological aspects and design challenges for the development towards proton colliders of increasing energy and luminosity.

Conversion of Propellant Grade Picrite to Spherical Nitroguanidine, an Insensitive Filler for Melt-Cast TNT Formulations

DTIC Science & Technology

1991-09-01

problem with the solvent/non-solvent process reported by ICT is the inability to recycle the mother liquors. Apparently "strawberries" or " sea urchins ...inevitable for the foreseeable future. Exceptions could include lower production rate items such as sea mines or missile warheads, or speLfic nunitions where...Leitz Orthomat 35 mm automatic camera on polaroid film type 667, Magnification ranged up to X42. 14K 1* Scanning Electron Microscopy ( SEM ) SEM was

The value of dentures.

PubMed

Levin, Roger P

2003-05-01

Dentures may be boring, but they are a major part of dentistry, and will be for the foreseeable future. While implants are growing in popularity, there will always be patients who opt for dentures. It is your duty to inform patients of the need to have their dentures remade periodically, to ensure excellent oral care. Be sure to manage patient expectation and to create an effective system for prompt payment. This will enable you to help patients achieve good oral health, while maximizing your profit.

Orbital Spacecraft Consumables Resupply System (OSCRS). Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1987-01-01

The objective was to establish an earth storable fluid tanker concept which satisfies the initial resupply requirements for the Gamma Ray Observatory (GRO) at a reasonable front end cost while providing growth potential for foreseeable future earth storable fluid resupply mission requirements. The estimated costs required to design, develop, qualify, fabricate, and deliver a flight tanker and its associated control avionics, ground support equipment (GSE), and processing facilities, and the contractors costs to support the first operations mission are reviewed.

Where does the Occluded Artery Trial leave the late open artery hypothesis?

PubMed Central

Lamas, Gervasio A; Hochman, Judith S

2007-01-01

As of April 2007 the early open artery hypothesis is alive and well, but the late open artery hypothesis is adrift. For the foreseeable future, stable patients with persistent occlusion of the infarct artery late after myocardial infarction, and without severe ischaemia or uncontrollable angina, should be managed initially with optimal medical treatment alone, and not with percutaneous coronary intervention. Efforts should focus on establishing reperfusion earlier, including reducing the time to patient presentation. PMID:17933981

Translations on Western Europe. Number 1153, The Danish Economy: A Projection for the Eighties

DTIC Science & Technology

1977-11-02

Source: Trades Council 3^ The leading economist of the Trades Council, Bjarne Hastrup , said that in the past we have believed too blindly in the...be expected in the repair field. Under director Blame Hastrup , Trades Coun- cil, said: "I expect legislation by the 1960’s [as written] at the...especially because of our tax system and the anticipated increase of leisure time in the future. But Bjarne Hastrup foresees on the basis of the current

Computational chemistry in pharmaceutical research: at the crossroads.

PubMed

Bajorath, Jürgen

2012-01-01

Computational approaches are an integral part of pharmaceutical research. However, there are many of unsolved key questions that limit the scientific progress in the still evolving computational field and its impact on drug discovery. Importantly, a number of these questions are not new but date back many years. Hence, it might be difficult to conclusively answer them in the foreseeable future. Moreover, the computational field as a whole is characterized by a high degree of heterogeneity and so is, unfortunately, the quality of its scientific output. In light of this situation, it is proposed that changes in scientific standards and culture should be seriously considered now in order to lay a foundation for future progress in computational research.

Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

NASA Technical Reports Server (NTRS)

Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

2011-01-01

Unmanned aerial systems, advanced cockpits, and air traffic management are all seeing dramatic increases in automation. However, while automation may take on some tasks previously performed by humans, humans will still be required to remain in the system for the foreseeable future. The collaboration between humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

New Metamaterials with Combined Subnano - and Mesoscale Topology for High-efficiency Catalytic Combustion Chambers of Innovative Gas Turbine Engines

NASA Astrophysics Data System (ADS)

Knysh, Yu A.; Xanthopoulou, G. G.

2018-01-01

The object of the study is a catalytic combustion chamber that provides a highly efficient combustion process through the use of effects: heat recovery from combustion, microvortex heat transfer, catalytic reaction and acoustic resonance. High efficiency is provided by a complex of related technologies: technologies for combustion products heat transfer (recuperation) to initial mixture, catalytic processes technology, technology for calculating effective combustion processes based on microvortex matrices, technology for designing metamaterials structures and technology for obtaining the required topology product by laser fusion of metal powder compositions. The mesoscale level structure provides combustion process with the use of a microvortex effect with a high intensity of heat and mass transfer. High surface area (extremely high area-to-volume ratio) created due to nanoscale periodic structure and ensures catalytic reactions efficiency. Produced metamaterial is the first multiscale product of new concept which due to combination of different scale level periodic topologies provides qualitatively new set of product properties. This research is aimed at solving simultaneously two global problems of the present: ensure environmental safety of transport systems and power industry, as well as the economy and rational use of energy resources, providing humanity with energy now and in the foreseeable future.

A Comparison of Simple Methods to Incorporate Material Temperature Dependency in the Green's Function Method for Estimating Transient Thermal Stresses in Thick-Walled Power Plant Components.

PubMed

Rouse, James; Hyde, Christopher

2016-01-06

The threat of thermal fatigue is an increasing concern for thermal power plant operators due to the increasing tendency to adopt "two-shifting" operating procedures. Thermal plants are likely to remain part of the energy portfolio for the foreseeable future and are under societal pressures to generate in a highly flexible and efficient manner. The Green's function method offers a flexible approach to determine reference elastic solutions for transient thermal stress problems. In order to simplify integration, it is often assumed that Green's functions (derived from finite element unit temperature step solutions) are temperature independent (this is not the case due to the temperature dependency of material parameters). The present work offers a simple method to approximate a material's temperature dependency using multiple reference unit solutions and an interpolation procedure. Thermal stress histories are predicted and compared for realistic temperature cycles using distinct techniques. The proposed interpolation method generally performs as well as (if not better) than the optimum single Green's function or the previously-suggested weighting function technique (particularly for large temperature increments). Coefficients of determination are typically above 0 . 96 , and peak stress differences between true and predicted datasets are always less than 10 MPa.

[Applied ecology: retrospect and prospect].

PubMed

He, Xingyuan; Zeng, Dehui

2004-10-01

Applied ecology is evolved into a principal part of modern ecology that rapidly develops. The major stimulus for the development of applied ecology roots in seeking the solutions for the problems of human populations, resources and environments. Through four decades, the science of applied ecology has been becoming a huge group of disciplines. The future for the applied ecology should concern more with human-influenced and managed ecosystems, and acknowledge humans as the components of ecosystems. Nowadays and in future, the top-priorities in applied ecology should include following fields: sustainable ecosystems and biosphere, ecosystem services and ecological design, ecological assessment of genetically modified organisms, ecology of biological invasions, epidemical ecology, ecological forecasting, ecological process and its control. The authors believe that the comprehensive and active research hotspots coupled some new traits would occur around these fields in foreseeable future.

Geographic variations in anthropogenic drivers that influence the vulnerability and resilience of social-ecological systems.

PubMed

Forbes, Bruce C; Fresco, Nancy; Shvidenko, Anatoly; Danell, Kjell; Chapin, F Stuart

2004-08-01

Across the circumpolar North large disparities in the distribution of renewable and nonrenewable resources, human population density, capital investments, and basic residential and transportation infrastructure combine to create recognizable hotspots of recent and foreseeable change. Northern Fennoscandia exemplifies a relatively benign situation due to its current economic and political stability. Northern Russia is experiencing rapid, mostly negative changes reflecting the general state of crisis since the collapse of the Soviet Union. North America enjoys a relatively stable regulatory structure to mitigate environmental degradation associated with industry, but is on the verge of approving massive new development schemes that would significantly expand the spatial extent of potentially affected social-ecological systems. Institutional or regulatory context influences the extent to which ecosystem services are buffered against environmental change. With or without a warming climate, certain geographic areas appear especially vulnerable to damages that may threaten their ability to supply goods and services in the near future. Climate change may exacerbate this situation in some places but may offer opportunities to enhance resilience in the long term.

Gravitational Self-Force: Orbital Mechanics Beyond Geodesic Motion

NASA Astrophysics Data System (ADS)

Barack, Leor

The question of motion in a gravitationally bound two-body system is a longstanding open problem of General Relativity. When the mass ratio eta; is small, the problem lends itself to a perturbative treatment, wherein corrections to the geodesic motion of the smaller object (due to radiation reaction, internal structure, etc.) are accounted for order by order in η, using the language of an effective gravitational self-force. The prospect for observing gravitational waves from compact objects inspiralling into massive black holes in the foreseeable future has in the past 15 years motivated a program to obtain a rigorous formulation of the self-force and compute it for astrophysically interesting systems. I will give a brief survey of this activity and its achievements so far, and will identify the challenges that lie ahead. As concrete examples, I will discuss recent calculations of certain conservative post-geodesic effects of the self-force, including the O(η ) correction to the precession rate of the periastron. I will highlight the way in which such calculations allow us to make a fruitful contact with other approaches to the two-body problem.

Wound healing applications of biogenic colloidal silver and gold nanoparticles: recent trends and future prospects.

PubMed

Ovais, Muhammad; Ahmad, Irshad; Khalil, Ali Talha; Mukherjee, Sudip; Javed, Rabia; Ayaz, Muhammad; Raza, Abida; Shinwari, Zabta Khan

2018-05-01

Nanotechnology has emerged as a prominent scientific discipline in the technological revolution of this millennium. The scientific community has focused on the green synthesis of metal nanoparticles as compared to physical and chemical methods due to its eco-friendly nature and high efficacy. Medicinal plants have been proven as the paramount source of various phytochemicals that can be used for the biogenic synthesis of colloidal silver and gold nanoparticles as compared to other living organisms, e.g., microbes and fungi. According to various scientific reports, the biogenic nanoparticles have shown promising potential as wound healing agents. However, not a single broad review article was present that demonstrates the wound healing application of biogenic silver and gold nanoparticles. Foreseeing the overall literature published, we for the first time intended to discuss the current trends in wound healing via biogenic silver and gold nanoparticles. Furthermore, light has been shed on the mechanistic aspects of wound healing along with futuristic discussion on the faith of biogenic silver and gold nanoparticles as potential wound healing agents.

Volume weighting the measure of the universe from classical slow-roll expansion

NASA Astrophysics Data System (ADS)

Sloan, David; Silk, Joseph

2016-05-01

One of the most frustrating issues in early universe cosmology centers on how to reconcile the vast choice of universes in string theory and in its most plausible high energy sibling, eternal inflation, which jointly generate the string landscape with the fine-tuned and hence relatively small number of universes that have undergone a large expansion and can accommodate observers and, in particular, galaxies. We show that such observations are highly favored for any system whereby physical parameters are distributed at a high energy scale, due to the conservation of the Liouville measure and the gauge nature of volume, asymptotically approaching a period of large isotropic expansion characterized by w =-1 . Our interpretation predicts that all observational probes for deviations from w =-1 in the foreseeable future are doomed to failure. The purpose of this paper is not to introduce a new measure for the multiverse, but rather to show how what is perhaps the most natural and well-known measure, volume weighting, arises as a consequence of the conservation of the Liouville measure on phase space during the classical slow-roll expansion.

Flood risk analysis and adaptive strategy in context of uncertainties: a case study of Nhieu Loc Thi Nghe Basin, Ho Chi Minh City

NASA Astrophysics Data System (ADS)

Ho, Long-Phi; Chau, Nguyen-Xuan-Quang; Nguyen, Hong-Quan

2013-04-01

The Nhieu Loc - Thi Nghe basin is the most important administrative and business area of Ho Chi Minh City. Due to system complexity of the basin such as the increasing trend of rainfall intensity, (tidal) water level and land subsidence, the simulation of hydrological, hydraulic variables for flooding prediction seems rather not adequate in practical projects. The basin is still highly vulnerable despite of multi-million USD investment for urban drainage improvement projects since the last decade. In this paper, an integrated system analysis in both spatial and temporal aspects based on statistical, GIS and modelling approaches has been conducted in order to: (1) Analyse risks before and after projects, (2) Foresee water-related risk under uncertainties of unfavourable driving factors and (3) Develop a sustainable flood risk management strategy for the basin. The results show that given the framework of risk analysis and adaptive strategy, certain urban developing plans in the basin must be carefully revised and/or checked in order to reduce the highly unexpected loss in the future

Patterning of conjugated polymers for organic optoelectronic devices.

PubMed

Xu, Youyong; Zhang, Fan; Feng, Xinliang

2011-05-23

Conjugated polymers have been attracting more and more attention because they possess various novel electrical, magnetical, and optical properties, which render them useful in modern organic optoelectronic devices. Due to their organic nature, conjugated polymers are light-weight and can be fabricated into flexible appliances. Significant research efforts have been devoted to developing new organic materials to make them competitive with their conventional inorganic counterparts. It is foreseeable that when large-scale industrial manufacture of the devices made from organic conjugated polymers is feasible, they would be much cheaper and have more functions. On one hand, in order to improve the performance of organic optoelectronic devices, it is essential to tune their surface morphologies by techniques such as patterning. On the other hand, patterning is the routine requirement for device processing. In this review, the recent progress in the patterning of conjugated polymers for high-performance optoelectronic devices is summarized. Patterning based on the bottom-up and top-down methods are introduced. Emerging new patterning strategies and future trends for conventional patterning techniques are discussed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Effect of lensing non-Gaussianity on the CMB power spectra

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Antony; Pratten, Geraint, E-mail: antony@cosmologist.info, E-mail: geraint.pratten@gmail.com

2016-12-01

Observed CMB anisotropies are lensed, and the lensed power spectra can be calculated accurately assuming the lensing deflections are Gaussian. However, the lensing deflections are actually slightly non-Gaussian due to both non-linear large-scale structure growth and post-Born corrections. We calculate the leading correction to the lensed CMB power spectra from the non-Gaussianity, which is determined by the lensing bispectrum. Assuming no primordial non-Gaussianity, the lowest-order result gives ∼ 0.3% corrections to the BB and EE polarization spectra on small-scales. However we show that the effect on EE is reduced by about a factor of two by higher-order Gaussian lensing smoothing,more » rendering the total effect safely negligible for the foreseeable future. We give a simple analytic model for the signal expected from skewness of the large-scale lensing field; the effect is similar to a net demagnification and hence a small change in acoustic scale (and therefore out of phase with the dominant lensing smoothing that predominantly affects the peaks and troughs of the power spectrum).« less

Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

NASA Technical Reports Server (NTRS)

Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

2016-01-01

Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

Tracking zebrafish larvae in group – Status and perspectives☆

PubMed Central

Martineau, Pierre R.; Mourrain, Philippe

2013-01-01

Video processing is increasingly becoming a standard procedure in zebrafish behavior investigations as it enables higher research throughput and new or better measures. This trend, fostered by the ever increasing performance-to-price ratio of the required recording and processing equipment, should be expected to continue in the foreseeable future, with video-processing based methods permeating more and more experiments and, as a result, expanding the very role of behavioral studies in zebrafish research. To assess whether the routine video tracking of zebrafish larvae directly in the Petri dish is a capability that can be expected in the near future, the key processing concepts are discussed and illustrated on published zebrafish studies when available or other animals when not. PMID:23707495

Storage system software solutions for high-end user needs

NASA Technical Reports Server (NTRS)

Hogan, Carole B.

1992-01-01

Today's high-end storage user is one that requires rapid access to a reliable terabyte-capacity storage system running in a distributed environment. This paper discusses conventional storage system software and concludes that this software, designed for other purposes, cannot meet high-end storage requirements. The paper also reviews the philosophy and design of evolving storage system software. It concludes that this new software, designed with high-end requirements in mind, provides the potential for solving not only the storage needs of today but those of the foreseeable future as well.

Near-Earth water sources: Ethics and fairness

NASA Astrophysics Data System (ADS)

Schwartz, James S. J.

2016-08-01

There is a small finite upper bound on the amount of easily accessible water in near-Earth space, including water from C-type NEAs and permanently shadowed lunar craters. Recent estimates put this total at about 3.7 ×1012kg . Given the non-renewable nature of this resource, we should begin thinking carefully about the regulation of near-Earth water sources (NEWS). This paper discusses this issue from an ethical vantage point, and argues that for the foreseeable future, the scientific use of NEWS should be prioritized over other potential uses of NEWS.

Western Europe: Battery forecast report - status 1995 and outlook. Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kellinghusen, G.

1996-09-01

This presentation will cover the following main topics: (1) The market situation and the market players; (2) The Western European starter battery market in 1995 and outlook and 3. New European starter battery coding system: European Type Number (ETN). The current situation in the Western Europe lead battery market has the following features: (a) Market globalization; (b) a dramatic erosion of prices; (c) the acceleration of technological change; (d) {open_quotes}time to market{close_quotes} as a new competitive dimension and, (e) a strong German currency in the foreseeable future.

Sudden Cardiac Risk Stratification with Electrocardiographic Indices - A Review on Computational Processing, Technology Transfer, and Scientific Evidence

PubMed Central

Gimeno-Blanes, Francisco J.; Blanco-Velasco, Manuel; Barquero-Pérez, Óscar; García-Alberola, Arcadi; Rojo-Álvarez, José L.

2016-01-01

Great effort has been devoted in recent years to the development of sudden cardiac risk predictors as a function of electric cardiac signals, mainly obtained from the electrocardiogram (ECG) analysis. But these prediction techniques are still seldom used in clinical practice, partly due to its limited diagnostic accuracy and to the lack of consensus about the appropriate computational signal processing implementation. This paper addresses a three-fold approach, based on ECG indices, to structure this review on sudden cardiac risk stratification. First, throughout the computational techniques that had been widely proposed for obtaining these indices in technical literature. Second, over the scientific evidence, that although is supported by observational clinical studies, they are not always representative enough. And third, via the limited technology transfer of academy-accepted algorithms, requiring further meditation for future systems. We focus on three families of ECG derived indices which are tackled from the aforementioned viewpoints, namely, heart rate turbulence (HRT), heart rate variability (HRV), and T-wave alternans. In terms of computational algorithms, we still need clearer scientific evidence, standardizing, and benchmarking, siting on advanced algorithms applied over large and representative datasets. New scenarios like electronic health recordings, big data, long-term monitoring, and cloud databases, will eventually open new frameworks to foresee suitable new paradigms in the near future. PMID:27014083

A possibility of avoiding surface roughness due to insects

NASA Technical Reports Server (NTRS)

Wortmann, F. X.

1984-01-01

Discussion of a method for eliminating turbulence caused by the formation of insect roughness upon the leading edges and fuselage, particularly in aircraft using BLC. The proposed technique foresees the use of elastic surfaces on which insect roughness cannot form. The operational characteristics of highly elastic rubber surface fastened to the wing leading edges and fuselage edges are examined. Some preliminary test results are presented. The technique is seen to be advantageous primarily for short-haul operations.

How do episodic and semantic memory contribute to episodic foresight in young children?

PubMed

Martin-Ordas, Gema; Atance, Cristina M; Caza, Julian S

2014-01-01

Humans are able to transcend the present and mentally travel to another time, place, or perspective. Mentally projecting ourselves backwards (i.e., episodic memory) or forwards (i.e., episodic foresight) in time are crucial characteristics of the human memory system. Indeed, over the past few years, episodic memory has been argued to be involved both in our capacity to retrieve our personal past experiences and in our ability to imagine and foresee future scenarios. However, recent theory and findings suggest that semantic memory also plays a significant role in imagining future scenarios. We draw on Tulving's definition of episodic and semantic memory to provide a critical analysis of their role in episodic foresight tasks described in the developmental literature. We conclude by suggesting future directions of research that could further our understanding of how both episodic memory and semantic memory are intimately connected to episodic foresight.

How do episodic and semantic memory contribute to episodic foresight in young children?

PubMed Central

Martin-Ordas, Gema; Atance, Cristina M.; Caza, Julian S.

2014-01-01

Humans are able to transcend the present and mentally travel to another time, place, or perspective. Mentally projecting ourselves backwards (i.e., episodic memory) or forwards (i.e., episodic foresight) in time are crucial characteristics of the human memory system. Indeed, over the past few years, episodic memory has been argued to be involved both in our capacity to retrieve our personal past experiences and in our ability to imagine and foresee future scenarios. However, recent theory and findings suggest that semantic memory also plays a significant role in imagining future scenarios. We draw on Tulving’s definition of episodic and semantic memory to provide a critical analysis of their role in episodic foresight tasks described in the developmental literature. We conclude by suggesting future directions of research that could further our understanding of how both episodic memory and semantic memory are intimately connected to episodic foresight. PMID:25071690

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neufeld, W.P.

Recently, the Trend Analysis Program (TAP) of the American Council of Life Insurance commissioned the Futures Group of Glastonbury, Connecticut, to examine the potential for large-scale catastrophic events in the near future. TAP was specifically concerned with five potential crises: the warming of the earth's atmosphere, the water shortage, the collapse of the physical infrastructure, the global financial crisis, and the threat of nuclear war. We are often unprepared to take action; in these cases, we lose an advantage we might have otherwise had. This is the whole idea behind forecasting: to foresee possibilities and to project how we canmore » respond. If we are able to create forecasts against which we can test policy options and choices, we may have the luxury of adopting policies ahead of events. Rather than simply fighting fires, we have the option of creating a future more to our choosing. Short descriptions of these five potential crises and, in some cases, possible solutions are presented.« less

Reflections on the present and future of upper limb prostheses.

PubMed

Farina, Dario; Amsüss, Sebastian

2016-01-01

Despite progress in research and media attention on active upper limb prostheses, presently the most common commercial upper limb prosthetic devices are not fundamentally different from solutions offered almost one century ago. Limited information transfer for both control and sensory-motor integration and challenges in socket technology have been major obstacles. By analysing the present state-of-the-art and academic achievements, we provide our opinion on the future of upper limb prostheses. We believe that surgical procedures for muscle reinnervation and osseointegration will become increasingly clinically relevant; muscle electrical signals will remain the main clinical means for prosthetic control; and chronic electrode implants, first in muscles (control), then in nerves (sensory feedback), will become viable clinical solutions. After decades of suspended clinically relevant progress, it is foreseeable that a new generation of upper limb prostheses will enter the market in the near future based on such advances, thereby offering substantial clinical benefit for patients.

Large-area, lightweight and thick biomimetic composites with superior material properties via fast, economic, and green pathways.

PubMed

Walther, Andreas; Bjurhager, Ingela; Malho, Jani-Markus; Pere, Jaakko; Ruokolainen, Janne; Berglund, Lars A; Ikkala, Olli

2010-08-11

Although remarkable success has been achieved to mimic the mechanically excellent structure of nacre in laboratory-scale models, it remains difficult to foresee mainstream applications due to time-consuming sequential depositions or energy-intensive processes. Here, we introduce a surprisingly simple and rapid methodology for large-area, lightweight, and thick nacre-mimetic films and laminates with superior material properties. Nanoclay sheets with soft polymer coatings are used as ideal building blocks with intrinsic hard/soft character. They are forced to rapidly self-assemble into aligned nacre-mimetic films via paper-making, doctor-blading or simple painting, giving rise to strong and thick films with tensile modulus of 45 GPa and strength of 250 MPa, that is, partly exceeding nacre. The concepts are environmentally friendly, energy-efficient, and economic and are ready for scale-up via continuous roll-to-roll processes. Excellent gas barrier properties, optical translucency, and extraordinary shape-persistent fire-resistance are demonstrated. We foresee advanced large-scale biomimetic materials, relevant for lightweight sustainable construction and energy-efficient transportation.

48 CFR 1371.105 - Foreseeable cost factors pertaining to different shipyard locations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... pertaining to different shipyard locations. 1371.105 Section 1371.105 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP... locations. Insert provision 1352.271-74, Foreseeable Cost Factors Pertaining to Different Shipyard Locations...

48 CFR 1371.105 - Foreseeable cost factors pertaining to different shipyard locations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... pertaining to different shipyard locations. 1371.105 Section 1371.105 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP... locations. Insert provision 1352.271-74, Foreseeable Cost Factors Pertaining to Different Shipyard Locations...

48 CFR 1371.105 - Foreseeable cost factors pertaining to different shipyard locations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... pertaining to different shipyard locations. 1371.105 Section 1371.105 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP... locations. Insert provision 1352.271-74, Foreseeable Cost Factors Pertaining to Different Shipyard Locations...

48 CFR 1371.105 - Foreseeable cost factors pertaining to different shipyard locations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... pertaining to different shipyard locations. 1371.105 Section 1371.105 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP... locations. Insert provision 1352.271-74, Foreseeable Cost Factors Pertaining to Different Shipyard Locations...

48 CFR 1371.105 - Foreseeable cost factors pertaining to different shipyard locations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... pertaining to different shipyard locations. 1371.105 Section 1371.105 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP... locations. Insert provision 1352.271-74, Foreseeable Cost Factors Pertaining to Different Shipyard Locations...

16 CFR 1500.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... similar wording descriptive of the hazard; (F) Precautionary measures describing the action to be followed... subjected to reasonably foreseeable damage or abuse, its design or manufacture may cause personal injury or... hazard if, in normal use or when subjected to reasonably foreseeable damage or abuse, its design or...

16 CFR 1500.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... similar wording descriptive of the hazard; (F) Precautionary measures describing the action to be followed... subjected to reasonably foreseeable damage or abuse, its design or manufacture may cause personal injury or... hazard if, in normal use or when subjected to reasonably foreseeable damage or abuse, its design or...

16 CFR 1500.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... similar wording descriptive of the hazard; (F) Precautionary measures describing the action to be followed... subjected to reasonably foreseeable damage or abuse, its design or manufacture may cause personal injury or... hazard if, in normal use or when subjected to reasonably foreseeable damage or abuse, its design or...

16 CFR 1500.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... similar wording descriptive of the hazard; (F) Precautionary measures describing the action to be followed... subjected to reasonably foreseeable damage or abuse, its design or manufacture may cause personal injury or... hazard if, in normal use or when subjected to reasonably foreseeable damage or abuse, its design or...

The fractal feature and price trend in the gold future market at the Shanghai Futures Exchange (SFE)

NASA Astrophysics Data System (ADS)

Wu, Binghui; Duan, Tingting

2017-05-01

The price of gold future is affected by many factors, which include the fluctuation of gold price and the change of trading environment. Fractal analysis can help investors gain better understandings of the price fluctuation and make reasonable investment decisions in the gold future market. After analyzing gold future price from January 2th, 2014 to April 12th, 2016 at the Shanghai Futures Exchange (SFE) in China, the conclusion is drawn that the gold future market has sustainability in each trading day, with all Hurst indexes greater than 0.5. The changing features of Hurst index indicate the sustainability of gold future market is strengthened first and weakened then. As a complicatedly nonlinear system, the gold future market can be well reflected by Elman neural network, which is capable of memorizing previous prices and particularly suited for forecasting time series in comparison with other types of neural networks. After analyzing the price trend in the gold future market, the results show that the relative error between the actual value of gold future and the predictive value of Elman neural network is smaller. This model that has a better performance in data fitting and predication, can help investors analyze and foresee the price tendency in the gold future market.

16 CFR § 1500.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... similar wording descriptive of the hazard; (F) Precautionary measures describing the action to be followed... subjected to reasonably foreseeable damage or abuse, its design or manufacture may cause personal injury or... hazard if, in normal use or when subjected to reasonably foreseeable damage or abuse, its design or...

Deposition of strontium-90 through October 1958; the global deposition of strontium-90 is discussed in relation to the absorption of the isotope by man.

PubMed

EISENBUD, M

1959-07-10

It is estimated that the global deposition of strontium-90 increased from 1.9 to 2.6 megacuries during the period from June 1957 to October 1958. During this time the stratospheric reservoir of strontium-90 increased from 1.4 to 4.3 megacuries. Approximately 90 percent of the deposition of debris now stored in the stratosphere will have occurred by 1970. In 1958, the strontium-90 content of powdered milk in the New York area averaged 5.9 micromicrocuries per gram of calcium in comparison with 3.9 micromicrocuries per gram of calcium for the previous year. For this region of the country, the strontium-90 content of milk appears to be increasing in proportion to the strontium-90 content of the soils from which the cows derive their forage. The upper limit of foreseeable contamination in milk can be estimated by assuming that this proportionality will continue until all of the strontium-90 has been deposited from the upper atmosphere. This procedure should yield estimates which tend to err on the side of safety. In this manner, it is estimated that the maximum foreseeable sustained level of milk contamination in the New York area is 11 micromicrocuries per gram of calcium. A child deriving its calcium from dairy sources may be expected to develop a skeleton having 5.5 micromicrocuries per gram of calcium. This estimate is double that made in June 1957 and reflects the increased stratospheric inventory due to U.S.S.R. detonations in 1958. The radiological dose to the skeleton from natural sources such as cosmic rays, radium, potassium, and so forth, is approximately 125 millirems per year. A skeletal burden of 5.5 micromicrocuries of strontium-90 per gram of calcium will deliver a dose of approximately 5.5 millirems per year to the bone marrow. The maximum foreseeable dose from strontium-90 in the New York area is thereby estimated to be about 5 percent of the dose due to natural radioactivity.

Paraffin-based hybrid rocket engines applications: A review and a market perspective

NASA Astrophysics Data System (ADS)

Mazzetti, Alessandro; Merotto, Laura; Pinarello, Giordano

2016-09-01

Hybrid propulsion technology for aerospace applications has received growing attention in recent years due to its important advantages over competitive solutions. Hybrid rocket engines have a great potential for several aeronautics and aerospace applications because of their safety, reliability, low cost and high performance. As a consequence, this propulsion technology is feasible for a number of innovative missions, including space tourism. On the other hand, hybrid rocket propulsion's main drawback, i.e. the difficulty in reaching high regression rate values using standard fuels, has so far limited the maturity level of this technology. The complex physico-chemical processes involved in hybrid rocket engines combustion are of major importance for engine performance prediction and control. Therefore, further investigation is ongoing in order to achieve a more complete understanding of such phenomena. It is well known that one of the most promising solutions for overcoming hybrid rocket engines performance limits is the use of liquefying fuels. Such fuels can lead to notably increased solid fuel regression rate due to the so-called "entrainment phenomenon". Among liquefying fuels, paraffin-based formulations have great potentials as solid fuels due to their low cost, availability (as they can be derived from industrial waste), low environmental impact and high performance. Despite the vast amount of literature available on this subject, a precise focus on market potential of paraffins for hybrid propulsion aerospace applications is lacking. In this work a review of hybrid rocket engines state of the art was performed, together with a detailed analysis of the possible applications of such a technology. A market study was carried out in order to define the near-future foreseeable development needs for hybrid technology application to the aforementioned missions. Paraffin-based fuels are taken into account as the most promising segment for market development.The present study is useful for driving future investigation and testing of paraffin-based fuels as solid fuels for hybrid propulsion technology, taking into account the needs of industrial applications of this technology.

Chiropractic Identity in the United States: Wisdom, Courage, and Strength.

PubMed

Good, Christopher J

2016-12-01

The objective of this paper was to discuss the chiropractic profession's identity and 3 contentious issues related to identity. The various clinical specialties and independent groups in the chiropractic profession are so different in their beliefs, practice styles, and political agendas that a common identity is unlikely to be created. Areas of disagreement, including advanced practice, vertebral subluxation, and the philosophy of chiropractic, continue to separate those in the profession. Doctors of chiropractic should accept that differences within the profession will remain for the foreseeable future and that the profession should allow each group to live peacefully and supportively alongside each other. If the profession embraces the ideals of truth, respect, and tolerance, it can continue to grow and provide diverse health care services well into the future.

Cost-effectiveness of the stream-gaging program in the Hawaii District

USGS Publications Warehouse

Matsuoka, I.; Lee, R.; Thomas, W.O.

1985-01-01

This project documents the results of a study of the cost-effectiveness of the stream-gaging program in the Hawaii District. The stream gages in the District were divided into two groups, the State of Hawaii and the Other Pacific Areas. Data uses and funding sources were identified for the 124 continuous stream gages currently being operated in the Hawaii District with a budget of $570,620. All the stream-gages were identified as having sufficient reason to continue their operation and they should be maintained in the program for the foreseeable future. (USGS)

History of Nuclear Weapons Design and Production

NASA Astrophysics Data System (ADS)

Oelrich, Ivan

2007-04-01

The nuclear build-up of the United States and the Soviet Union during the Cold War is often portrayed as an arms race. Some part was indeed a bilateral competition, but much was the result of automatic application of technical advances as they became available, without careful consideration of strategic implications. Thus, the history of nuclear weapon design is partly designers responding to stated military needs and partly the world responding to constant innovations in nuclear capability. Today, plans for a new nuclear warhead are motivated primarily by the desire to maintain a nuclear design and production capability for the foreseeable future.

Reusable Launch Vehicle (RLV) Market Analysis Model

NASA Technical Reports Server (NTRS)

Prince, Frank A.

1999-01-01

The RLV Market Analysis model is at best a rough order approximation of actual market behavior. However, it does give a quick indication if the flights exists to enable an economically viable RLV, and the assumptions necessary for the vehicle to capture those flights. Additional analysis, market research, and updating with the latest information on payloads and launches would improve the model. Plans are to update the model as new information becomes available and new requirements are levied. This tool will continue to be a vital part of NASA's RLV business analysis capability for the foreseeable future.

The global war on terror: four years on.

PubMed

Rogers, Paul

2006-01-01

The progress of the global war on terror in the four years since the 9 September 2001 attack on New York and Washington is surveyed, with particular reference to its objective of curtailing the activities of al-Qaida, the situation in Afghanistan and Iraq, and the threat to the United States from the 'axis of evil'. It is suggested that the US is unlikely to withdraw from Iraq in particular because of its dependency upon access to Middle East oil in the foreseeable future, and accordingly that the global war on terror is likely to continue for several years at least.

Artificial Intelligence in Autonomous Telescopes

NASA Astrophysics Data System (ADS)

Mahoney, William; Thanjavur, Karun

2011-03-01

Artificial Intelligence (AI) is key to the natural evolution of today's automated telescopes to fully autonomous systems. Based on its rapid development over the past five decades, AI offers numerous, well-tested techniques for knowledge based decision making essential for real-time telescope monitoring and control, with minimal - and eventually no - human intervention. We present three applications of AI developed at CFHT for monitoring instantaneous sky conditions, assessing quality of imaging data, and a prototype for scheduling observations in real-time. Closely complementing the current remote operations at CFHT, we foresee further development of these methods and full integration in the near future.

Geriatric restorative care - the need, the demand and the challenges

PubMed Central

Nadig, Roopa R; Usha, G; Kumar, Vinod; Rao, Raghoothama; Bugalia, Anupriya

2011-01-01

Increased life expectancy is causing an explosion of the aging population that will continue now and in the foreseeable future. Improved quality of life at old age will demand tooth retention and consequently the need for restorative care. Retaining teeth disease free and maintaining them amidst multitude of risk factors associated with old age, is a multi- faceted challenge. This review article discusses the etiology of various dental diseases seen in older dentate population and their management keeping in mind the special needs of these matured people, so as to render a professional service that is sensitive and caring. PMID:22025819

Self-control program in the treatment of obesity.

PubMed

Rosen, L W

1981-06-01

In a pilot study utilizing self-control techniques for the purpose of modifying the cue-reactive eating habits of obese patients, three subjects maintained a continuous weight loss throughout the first year of treatment. Techniques included goal setting, self-monitoring, brief delay and self-confrontation prior to eating unauthorized food and direct observation of oneself in a mirror when eating unauthorized food. All patients are expected to remain in treatment for the foreseeable future with no termination of the program despite apparent success with regard to control of their feeding disturbance. The rationale for this approach is discussed.

29 CFR 825.302 - Employee notice requirements for foreseeable FMLA leave.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.302 Employee notice requirements for foreseeable FMLA leave. (a) Timing of... foster care, planned medical treatment for a serious health condition of the employee or of a family...

29 CFR 825.313 - Failure to provide certification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.313 Failure to provide certification. (a) Foreseeable leave. In the case of foreseeable leave, if... expiration of the 15-day time period, if the employee takes leave during such period. (b) Unforeseeable leave...

29 CFR 825.313 - Failure to provide certification.

Code of Federal Regulations, 2013 CFR

2013-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.313 Failure to provide certification. (a) Foreseeable leave. In the case of foreseeable leave, if... expiration of the 15-day time period, if the employee takes leave during such period. (b) Unforeseeable leave...

29 CFR 825.313 - Failure to provide certification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.313 Failure to provide certification. (a) Foreseeable leave. In the case of foreseeable leave, if... expiration of the 15-day time period, if the employee takes leave during such period. (b) Unforeseeable leave...

29 CFR 825.302 - Employee notice requirements for foreseeable FMLA leave.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.302 Employee notice requirements for foreseeable FMLA leave. (a) Timing of... foster care, planned medical treatment for a serious health condition of the employee or of a family...

29 CFR 825.302 - Employee notice requirements for foreseeable FMLA leave.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.302 Employee notice requirements for foreseeable FMLA leave. (a) Timing of... foster care, planned medical treatment for a serious health condition of the employee or of a family...

29 CFR 825.302 - Employee notice requirements for foreseeable FMLA leave.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.302 Employee notice requirements for foreseeable FMLA leave. (a) Timing of... foster care, planned medical treatment for a serious health condition of the employee or of a family...

29 CFR 825.313 - Failure to provide certification.

Code of Federal Regulations, 2012 CFR

2012-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.313 Failure to provide certification. (a) Foreseeable leave. In the case of foreseeable leave, if... expiration of the 15-day time period, if the employee takes leave during such period. (b) Unforeseeable leave...

29 CFR 825.313 - Failure to provide certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.313 Failure to provide certification. (a) Foreseeable leave. In the case of foreseeable leave, if... expiration of the 15-day time period, if the employee takes leave during such period. (b) Unforeseeable leave...

Negligent Liability and the Foreseeability Factor: A Critical Issue for School Counselors.

ERIC Educational Resources Information Center

Henderson, Donald H.

1987-01-01

Notes that negligent liability suits involving school counselors seem to be increasing. Cites cases, most of which involved defendant's alleged negligence emanating from failure to provide reasonable care to individuals who were later injured or killed. Emphasizes role of foreseeability in determining outcome of negligence cases. Indicates areas…

Judgments of cause and blame: the effects of intentionality and foreseeability.

PubMed

Lagnado, David A; Channon, Shelley

2008-09-01

What are the factors that influence everyday attributions of cause and blame? The current studies focus on sequences of events that lead to adverse outcomes, and examine people's cause and blame ratings for key events in these sequences. Experiment 1 manipulated the intentional status of candidate causes and their location in a causal chain. Participants rated intentional actions as more causal, and more blameworthy, than unintentional actions or physical events. There was also an overall effect of location, with later events assigned higher ratings than earlier events. Experiment 2 manipulated both intentionality and foreseeability. The preference for intentional actions was replicated, and there was a strong influence of foreseeability: actions were rated as more causal and more blameworthy when they were highly foreseeable. These findings are interpreted within two prominent theories of blame, [Shaver, K. G. (1985). The attribution of blame: Causality, responsibility, and blameworthiness. New York: Springer-Verlag] and [Alicke, M. D. (2000). Culpable control and the psychology of blame. Psychological Bulletin, 126, 556-574]. Overall, it is argued that the data are more consistent with Alicke's model of culpable control.

Analyzing critical material demand: A revised approach.

PubMed

Nguyen, Ruby Thuy; Fishman, Tomer; Zhao, Fu; Imholte, D D; Graedel, T E

2018-07-15

Apparent consumption has been widely used as a metric to estimate material demand. However, with technology advancement and complexity of material use, this metric has become less useful in tracking material flows, estimating recycling feedstocks, and conducting life cycle assessment of critical materials. We call for future research efforts to focus on building a multi-tiered consumption database for the global trade network of critical materials. This approach will help track how raw materials are processed into major components (e.g., motor assemblies) and eventually incorporated into complete pieces of equipment (e.g., wind turbines). Foreseeable challenges would involve: 1) difficulty in obtaining a comprehensive picture of trade partners due to business sensitive information, 2) complexity of materials going into components of a machine, and 3) difficulty maintaining such a database. We propose ways to address these challenges such as making use of digital design, learning from the experience of building similar databases, and developing a strategy for financial sustainability. We recommend that, with the advancement of information technology, small steps toward building such a database will contribute significantly to our understanding of material flows in society and the associated human impacts on the environment. Copyright © 2018 Elsevier B.V. All rights reserved.

Higher Order Time Integration Schemes for the Unsteady Navier-Stokes Equations on Unstructured Meshes

NASA Technical Reports Server (NTRS)

Jothiprasad, Giridhar; Mavriplis, Dimitri J.; Caughey, David A.

2002-01-01

The rapid increase in available computational power over the last decade has enabled higher resolution flow simulations and more widespread use of unstructured grid methods for complex geometries. While much of this effort has been focused on steady-state calculations in the aerodynamics community, the need to accurately predict off-design conditions, which may involve substantial amounts of flow separation, points to the need to efficiently simulate unsteady flow fields. Accurate unsteady flow simulations can easily require several orders of magnitude more computational effort than a corresponding steady-state simulation. For this reason, techniques for improving the efficiency of unsteady flow simulations are required in order to make such calculations feasible in the foreseeable future. The purpose of this work is to investigate possible reductions in computer time due to the choice of an efficient time-integration scheme from a series of schemes differing in the order of time-accuracy, and by the use of more efficient techniques to solve the nonlinear equations which arise while using implicit time-integration schemes. This investigation is carried out in the context of a two-dimensional unstructured mesh laminar Navier-Stokes solver.

Biosensors and bioelectronics on smartphone for portable biochemical detection.

PubMed

Zhang, Diming; Liu, Qingjun

2016-01-15

Smartphone has been widely integrated with sensors, such as test strips, sensor chips, and hand-held detectors, for biochemical detections due to its portability and ubiquitous availability. Utilizing built-in function modules, smartphone is often employed as controller, analyzer, and displayer for rapid, real-time, and point-of-care monitoring, which can significantly simplify design and reduce cost of the detecting systems. This paper presents a review of biosensors and bioelectronics on smartphone for portable biochemical detections. The biosensors and bioelectronics based on smartphone can mainly be classified into biosensors using optics, surface plasmon resonance, electrochemistry, and near-field communication. The developments of these biosensors and bioelectronics on smartphone are reviewed along with typical biochemical detecting cases. Sensor strategies, detector attachments, and coupling methods are highlighted to show designs of the compact, lightweight, and low-cost sensor systems. The performances and advantages of these designs are introduced with their applications in healthcare diagnosis, environment monitoring, and food evaluation. With advances in micro-manufacture, sensor technology, and miniaturized electronics, biosensor and bioelectronic devices on smartphone can be used to perform biochemical detections as common and convenient as electronic tag readout in foreseeable future. Copyright © 2015 Elsevier B.V. All rights reserved.

VVER Reactor Safety in Eastern Europe and Former Soviet Union

NASA Astrophysics Data System (ADS)

Papadopoulou, Demetra

2012-02-01

VVER Soviet-designed reactors that operate in Eastern Europe and former Soviet republics have heightened international concern for years due to major safety deficiencies. The governments of countries with VVER reactors have invested millions of dollars toward improving the safety of their nuclear power plants. Most of these reactors will continue to operate for the foreseeable future since they provide urgently-needed electrical power. Given this situation, this paper assesses the radiological consequences of a major nuclear accident in Eastern Europe. The paper also chronicles the efforts launched by the international nuclear community to improve the safety of the reactors and notes the progress made so far through extensive collaborative efforts in Armenia, Bulgaria, the Czech Republic, Hungary, Kazakhstan, Lithuania, Russia, Slovakia, and Ukraine to reduce the risks of nuclear accidents. Western scientific and technical staff collaborated with these countries to improve the safety of their reactor operations by strengthening the ability of the regulator to perform its oversight function, installing safety equipment and technologies, investing time in safety training, and working diligently to establish an enduring safety culture. Still, continued safety improvement efforts are necessary to ensure safe operating practices and achieve timely phase-out of older plants.

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications.

PubMed

Eliaz, Noam; Metoki, Noah

2017-03-24

Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials. CaP coating technologies are summarized, with a focus on electrochemical processes. Theories on the formation of transient precursor phases in biomineralization, the dissolution and reprecipitation as bone of CaPs are discussed. A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs. We conclude by foreseeing the future of CaPs.

The Myth of Community Differences as the Cause of Variations Among IRBs

PubMed Central

Klitzman, Robert

2013-01-01

Background Although variations among institutional review boards (IRBs) have been documented for 30 years, they continue, raising crucial questions as to why they persist as well as how IRBs view and respond to these variations. Methods In-depth, 2-hour interviews were conducted with 46 IRB chairs, administrators, and members. The leadership of 60 U.S. IRBs were contacted (every fourth one in the list of the top 240 institutions by NIH funding). IRB leaders from 34 of these institutions were interviewed (response rate = 55%). Results The interviewees suggest that differences often persist because IRBs think these are legitimate, and regulations permit variations due to differing “community values.” Yet, these variations frequently appear to stem more from differences in institutional and subjective personality factors, and from “more eyes” examining protocols, trying to foresee all potential future logistical problems, than from the values of the communities from which research participants are drawn. However, IRBs generally appear to defend these variations as reflecting underlying differences in community norms. Conclusions These data pose critical questions for policy and practice. Attitudinal changes and education among IRBs, principal investigators (PIs), policymakers, and others and research concerning these issues are needed. PMID:25285236

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

PubMed Central

Eliaz, Noam; Metoki, Noah

2017-01-01

Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials. CaP coating technologies are summarized, with a focus on electrochemical processes. Theories on the formation of transient precursor phases in biomineralization, the dissolution and reprecipitation as bone of CaPs are discussed. A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs. We conclude by foreseeing the future of CaPs. PMID:28772697

Time and length scales within a fire and implications for numerical simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

TIESZEN,SHELDON R.

2000-02-02

A partial non-dimensionalization of the Navier-Stokes equations is used to obtain order of magnitude estimates of the rate-controlling transport processes in the reacting portion of a fire plume as a function of length scale. Over continuum length scales, buoyant times scales vary as the square root of the length scale; advection time scales vary as the length scale, and diffusion time scales vary as the square of the length scale. Due to the variation with length scale, each process is dominant over a given range. The relationship of buoyancy and baroclinc vorticity generation is highlighted. For numerical simulation, first principlesmore » solution for fire problems is not possible with foreseeable computational hardware in the near future. Filtered transport equations with subgrid modeling will be required as two to three decades of length scale are captured by solution of discretized conservation equations. By whatever filtering process one employs, one must have humble expectations for the accuracy obtainable by numerical simulation for practical fire problems that contain important multi-physics/multi-length-scale coupling with up to 10 orders of magnitude in length scale.« less

Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?

PubMed

Dulloo, A G; Jacquet, J; Montani, J-P; Schutz, Y

2012-12-01

According to Lavoisier, 'Life is combustion'. But to what extent humans adapt to changes in food intake through adaptive thermogenesis--by turning down the rate of heat production during energy deficit (so as to conserve energy) or turning it up during overnutrition (so as to dissipate excess calories)--has been one of the most controversial issues in nutritional sciences over the past 100 years. The debate nowadays is not whether adaptive thermogenesis exists or not, but rather about its quantitative importance in weight homoeostasis and its clinical relevance to the pathogenesis and management of obesity. Such uncertainties are likely to persist in the foreseeable future primarily because of limitations to unobtrusively measure changes in energy expenditure and body composition with high enough accuracy and precision, particularly when even small inter-individual variations in thermogenesis can, in dynamic systems and over the long term, be important in the determining weight maintenance in some and obesity and weight regain in others. This paper reviews the considerable body of evidence, albeit fragmentary, suggesting the existence of quantitatively important adaptive thermogenesis in several compartments of energy expenditure in response to altered food intake. It then discusses the various limitations that lead to over- or underestimations in its assessment, including definitional and semantics, technical and methodological, analytical and statistical. While the role of adaptive thermogenesis in human weight regulation is likely to remain more a concept than a strictly 'quantifiable' entity in the foreseeable future, the evolution of this concept continues to fuel exciting hypothesis-driven mechanistic research which contributes to advance knowledge in human metabolism and which is bound to result in improved strategies for the management of a healthy body weight. © 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity.

Application of Human-Autonomy Teaming (HAT) Patterns to Reduced Crew Operations (RCO)

NASA Technical Reports Server (NTRS)

Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

2016-01-01

As part of the Air Force - NASA Bi-Annual Research Council Meeting, slides will be presented on recent Reduced Crew Operations (RCO) work. Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. A methodology for identifying HAT patterns to an advanced cockpit project is discussed.

SNOMED CT's RF2: Is the future bright?

PubMed

Ceusters, Werner

2011-01-01

SNOMED CT's new RF2 format is said to come with features for better configuration management of the SNOMED vocabulary, thereby accommodating evolving requirements without the need for further fundamental change in the foreseeable future. Although the available documentation is not yet convincing enough to support this claim, the newly introduced Model Component hierarchy and associated reference set mechanism seem to hold real promise of being able to deal successfully with a number of ontological issues that have been discussed in the recent literature. Backed up by a study of the old and new format and of the relevant literature and documentation, three recommendations are presented that would free SNOMED CT from use-mention confusions, unclear referencing of real-world entities and uninformative reasons for change in a way that does not force SNOMED CT to take a specific philosophical or ontological position.

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future

PubMed Central

Chan, Bryan A.

2015-01-01

In recent years, there has been a major paradigm shift in the management of non-small cell lung cancer (NSCLC). NSCLC should now be further sub-classified by histology and driver mutation if one is known or present. Translational research advances now allow such mutations to be inhibited by either receptor monoclonal antibodies (mAb) or small molecule tyrosine kinase inhibitors (TKI). Whilst empirical chemotherapy with a platinum-doublet remains the gold standard for advanced NSCLC without a known driver mutation, targeted therapy is pushing the boundary to significantly improve patient outcomes and quality of life. In this review, we will examine the major subtypes of oncogenic drivers behind NSCLC as well as the development of targeted agents available to treat them both now and in the foreseeable future. PMID:25806345

Modelling and evaluating municipal solid waste management strategies in a mega-city: the case of Ho Chi Minh City.

PubMed

ThiKimOanh, Le; Bloemhof-Ruwaard, Jacqueline M; van Buuren, Joost Cl; van der Vorst, Jack Gaj; Rulkens, Wim H

2015-04-01

Ho Chi Minh City is a large city that will become a mega-city in the near future. The city struggles with a rapidly increasing flow of municipal solid waste and a foreseeable scarcity of land to continue landfilling, the main treatment of municipal solid waste up to now. Therefore, additional municipal solid waste treatment technologies are needed. The objective of this article is to support decision-making towards more sustainable and cost-effective municipal solid waste strategies in developing countries, in particular Vietnam. A quantitative decision support model is developed to optimise the distribution of municipal solid waste from population areas to treatment plants, the treatment technologies and their capacities for the near future given available infrastructure and cost factors. © The Author(s) 2015.

Value of Seasonal Fuzzy-based Inflow Prediction in the Jucar River Basin

NASA Astrophysics Data System (ADS)

Pulido-Velazquez, M.; Macian-Sorribes, H.

2016-12-01

The development and application of climate services in Integrated Water Resources Management (IWRM) is said to add important benefits in terms of water use efficiency due to an increase ability to foresee future water availability. A method to evaluate the economic impact of these services is presented, based on the use of hydroeconomic modelling techniques (hydroeconomic simulation) to compare the net benefits from water use in the system with and without the inflow forecasting. The Jucar River Basin (Spain) has been used as case study. Operating rules currently applied in the basin were assessed using fuzzy rule-based (FRB) systems via a co-development process involving the system operators. These operating rules use as input variable the hydrological inflows in several sub-basins, which need to be foreseen by the system operators. The inflow forecasting mechanism to preview water availability in the irrigation season (May-September) relied on fuzzy regression in which future inflows were foreseen based on past inflows and rainfall in the basin. This approach was compared with the current use of the two past year inflows for projecting the future inflow. For each irrigation season, the previewed inflows were determined using both methods and their impact on the system operation assessed through a hydroeconomic DSS. Results show that the implementation of the fuzzy inflow forecasting system offers higher economic returns. Another advantage of the fuzzy approach regards to the uncertainty treatment using fuzzy numbers, which allow us to estimate the uncertainty range of the expected benefits. Consequently, we can use the fuzzy approach to estimate the uncertainty associated with both the prediction and the associated benefits.

Reflections on the Last 25 Years of the American Otological Society and Thoughts on its Future.

PubMed

Welling, D Bradley; Jackler, Robert K

2018-04-01

To review contributions of the American Otological Society (AOS) over the most recent quarter century (1993-2018) and to comment on possible future evolution of the field during the quarter century to come. Retrospective review of selected topics from the AOS transactions, distinguished lectureships over the past 25 years, and selective reflection by the authors. Speculation on potential advances of the next quarter century derived from emerging topics in the current literature and foreseeable trends in science and technology are also proffered for consideration (and possible future ridicule). Integration of multiple disciplines including bioengineering, medical imaging, genetics, molecular biology, physics, and evidence based medicine have substantially benefitted the practice of otology over the past quarter century. The impact of the contributions of members of the AOS in these developments cannot be over estimated. Further scientific advancement will certainly accelerate change in the practice of otologic surgery and medicine over the coming decade in ways that will be marvelous to behold.

The Future of the U.S. Nuclear Weapons Program

NASA Astrophysics Data System (ADS)

Brooks, Linton F.

2007-03-01

This paper will examine our plans for the future of the U.S. nuclear weapons program including efforts to ``transform'' the stockpile and supporting infrastructure. We proceed from the premise that the United States will need a safe, secure, and reliable nuclear deterrent for the foreseeable future. Moreover, the Stockpile Stewardship Program is working. Today's stockpile---comprised of legacy warheads left over from the Cold War---is safe and reliable. That said, we see increased risk, absent nuclear testing, in assuring the long-term safety and reliability of our current stockpile. Nor is today's nuclear weapons complex sufficiently ``responsive'' to fixing technical problems in the stockpile, or to potential adverse geopolitical change. Our task is to work to ensure that the U.S. nuclear weapons enterprise, including the stockpile and supporting infrastructure, meets long-term national security needs. Our approach is to develop and field replacement warheads for the legacy stockpile---so-called Reliable Replacement Warheads (RRW)---as a means to transform both the nuclear stockpile and supporting infrastructure.

Health and urban living.

PubMed

Dye, Christopher

2008-02-08

The majority of people now live in urban areas and will do so for the foreseeable future. As a force in the demographic and health transition, urbanization is associated with falling birth and death rates and with the shift in burden of illness from acute childhood infections to chronic, noncommunicable diseases of adults. Urban inhabitants enjoy better health on average than their rural counterparts, but the benefits are usually greater for the rich than for the poor, thus magnifying the differences between them. Subject to better evidence, I suggest that the main obstacles to improving urban health are not technical or even financial, but rather are related to governance and the organization of civil society.

Stretching the managed care dollar in the new millennium: the practice of detailing primary care physicians.

PubMed

Hill, Cynthia D; Bunn, Douglas N; Hawkins, Jenny Rae

2002-01-01

Pharmaceutical expenditures in this country are on the rise and the increase is expected to continue at double-digit rates in the foreseeable future. This study focuses on the ways in which the managed care industry can impact pharmaceutical costs through peer-to-peer data sharing or academic detailing. Making use of analysis in conjunction with a major Midwestern Health Maintenance Organization, we evaluate the immediate impacts of academic detailing efforts, and find it to have a substantial mitigating impact on pharmaceutical trends. Moreover, we find academic detailing to be cost-effective means of altering physician-prescribing behavior.

Global change and carrying capacity: Implications for life on Earth

NASA Technical Reports Server (NTRS)

Ehrlich, Paul R.; Daily, Gretchen C.; Ehrlich, Anne H.; Matson, Pamela; Vitousek, Peter

1989-01-01

Determining the long-term number of people that the planet can support without irreversibly reducing its ability to support people in the future, i.e., the carrying capacity of the Earth, is an exceedingly complex problem. About all that is known for certain is that, with present and foreseeable technologies, the human population has already exceeded the capacity. The reduction in carrying capacity that can be expected to result from direct human impacts on resources and the environment and from our indirect impacts of the climate system is discussed. Global warming and modeling global change and food security are also discussed with respect to carrying capacity.

Prioritization of remedial actions for radioactive waste burials in the Chernobyl exclusion zone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crossland, Ian

2013-07-01

Large volumes of radioactive waste were urgently buried in the Chernobyl Exclusion Zone (ChEZ) in the aftermath of the 1986 accident. Twenty-six years later, decisions must be taken about whether and how to remediate these sites. An attempt to resolve two key issues is described here: 1. How to assess the hazards posed by these facilities, recognizing that, for the foreseeable future, the Chernobyl Exclusion Zone will remain under institutional control? and 2. What standards to apply in deciding the extent of remediation? This paper presents an examination of the issues and proposes a simple decision-making process. (authors)

Environmental stratification framework and water-quality monitoring design strategy for the Islamic Republic of Mauritania, Africa

USGS Publications Warehouse

Friedel, Michael J.

2008-01-01

Mauritania anticipates an increase in mining activities throughout the country and into the foreseeable future. Because mining-induced changes in the landscape are likely to affect their limited ground-water resources and sensitive aquatic ecosystems, a water-quality assessment program was designed for Mauritania that is based on a nationally consistent environmental stratification framework. The primary objectives of this program are to ensure that the environmental monitoring systems can quantify near real-time changes in surface-water chemistry at a local scale, and quantify intermediate- to long-term changes in groundwater and aquatic ecosystems over multiple scales.

Virulence determinants of pandemic influenza viruses

PubMed Central

Tscherne, Donna M.; García-Sastre, Adolfo

2011-01-01

Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality. The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential. Currently, the combination of factors that drives the emergence of pandemic influenza is unclear, making it impossible to foresee the details of a future outbreak. Identification and characterization of influenza A virus virulence determinants may provide insight into genotypic signatures of pathogenicity as well as a more thorough understanding of the factors that give rise to pandemics. PMID:21206092

How Can the Science Community Support Reality Based Policies to Reducing the Escalating Toll of Natural Hazards?

NASA Astrophysics Data System (ADS)

Thomas, E. A.

2012-12-01

Worldwide, the toll of disaster damage caused by foreseeable natural hazards is growing, despite the fact that science is increasingly able to quantify the risk and foresee the likely location of natural events (NCDC 2012; NHC 2010). Those events can cause disastrous consequences if human built infrastructure is not properly designed for both the current state and future events (IBHS, 2012). Our existing approaches are not working at reducing the mounting toll of disasters which follow foreseeable natural events. Rather, even if the climate were not changing, current land use decisions coupled with development, engineering, design, and construction practices are significantly contributing to further increasing an unsustainable toll from disasters (Pielke, Gratz et al. 2007). Safe and proper construction practices developed to reduce flood losses (e.g. Design for Flooding, Watson, Adams et al., 2010) are all too often thought of as a zero sum situation where the community wins and the developer loses. In reality, the United States and the rest of the world often can find win-win solutions based on sound economics, law, ethics, and environmental sustainability that will benefit communities, developers, and natural hazard risk mitigation practitioners. While such solutions are being implemented in a fragmentary manner throughout the United States, communities implementing these solutions are increasingly working together in peer networks, such as the Natural Hazard Mitigation Association (NHMA)'s Resilient Neighbors Network. Examples include the Urban Drainage and Flood Control District that covers the metropolitan Denver area and recent work in Tulsa, Oklahoma. This presentation will set forth the scientific, ethical, and legal basis of higher development standards which, when combined with good negotiations techniques, can significantly decrease the terrible misery from wildfires, tornadoes, floods, and other natural disasters. Communities clearly have the legal right to implement safe design standards (Thomas, Riley Medlock 2008); yet all too often do not (NOAA, 2010). The required negotiations techniques must include outreach even to those who believe the topics of climate change and sustainability are some sort of plot against property rights and the free enterprise system. The presentation will also challenge the scientific community to support reasoned efforts to better prepare society for the even greater challenges posed by climate variability, uncertainty, and change: to work with practitioners who seek to build a safe and sustainable future to identify gaps in scientific knowledge and help develop workable solutions at the local level. Edward A. Thomas Esq. President Natural Hazard Mitigation Association

Energy [R]Evolution: Opportunities for Decarbonizing Canada

NASA Astrophysics Data System (ADS)

Byrne, J. M.

2016-12-01

The future of conventional energy in Canada is uncertain. World oil prices have suffered steep declines recently and there are no strong arguments for recovery in the foreseeable future. The country is now engaged in serious debates and discussions over the value of GHG emissions, pipelines, oil and gas operations, and renewable energy. Oilsands deposits in northern Alberta require long-term investment and decades of consistent sales to repay those investments. The election of more progressive governments in Alberta and Canada may provide the national and global credibility and opportunity to address the environmental problems caused by Oilsands and other fossil fuel developments. The discussion will focus on the possible ways forward for Canada to diversify the regional and national economy with renewable energy networks, thereby meeting our Paris GHG emission reduction commitments. The end goal of this work is to see the Canadian economy decarbonized within two decades.

Lightweight telescopes for lunar observatories

NASA Astrophysics Data System (ADS)

Rozelot, J. P.; Bingham, R.; Walker, D.

1994-06-01

Future optical observatories in space will require telescopes of very high resolution. To satisfy this demand, technology must be developed for large mirrors capable of diffraction-limited imaging. Conventional monolithic glass substrates (light-weight or not) have serious limitations for future development. In particular, glass is susceptible to fracture during ground-handling, transport and launch. An alternative solution is aluminium. It has lower cost, increased strength, easier and safer methods of fixing, amongst other advantages. It is readily lightweighted and can be produced with good polishing quality with nickel coating. We foresee applications for satellite telescope for astronomy, remote sensing, surveys of asteroids and debris in space. Furthermore, this technology is ideally suitable for lunar mounted interferometric experiments - as mirrors can be easily replicate, saving cost - and for telescopes deployed on planetary surfaces. Some results from the European Eureka Large Active Mirrors in Aluminium (LAMA) are here presented, which show the feasibility of such systems.

Will our children be healthy adults? Applying science to public health policy.

PubMed

Law, Catherine

2010-12-01

Cardiovascular disease is predicted to be a leading cause of death and disability worldwide for the foreseeable future. Observational studies link a variety of prevalent early life experiences (for example, smoking in pregnancy, child poverty) to increased risk of adult cardiovascular disease. Experimental animal studies suggest plausible causal relationships. However, there has been little consideration of how to use this wealth of information to benefit children's futures. Policy documents have drawn on research evidence to recognise that early experience influences life chances, the development of human capital, and long-term health. This has led to a general policy emphasis on prevention and early intervention. To date, there are few examples of the evidence base being useful in shaping specific policies, despite potential to do so, and some examples of policy misunderstanding of science. Minor changes to the perspectives of epidemiological research in this area might greatly increase the potential for evidence-based policy.

Using the mass media to inform and educate the public about planetary protection and exploration risks

NASA Astrophysics Data System (ADS)

Race, M.

For the foreseeable future, the public will continue to learn piecemeal about the latest advances in Astrobiology through headlines and mass media coverage of missions, discoveries or controversies. Journalists and reporters are themselves unschooled in this emerging interdisciplinary field, yet play a critical role in explaining details to the public. While it is important to develop curricular materials for future use in formal educational settings, it is equally important to find novel ways for educating and updating journalists in this fast paced field. Risk communication plans for Mars exploration and other solar system missions should include special efforts aimed at assisting mass media professionals in both their informational and educational roles. If journalists and reporters have a deeper and more comprehensive understanding of the science and societal issues associated with missions, the result may well be more accurate explanations, improved public understanding, and continued support for exploration.

Bioinformatics: perspectives for the future.

PubMed

Costa, Luciano da Fontoura

2004-12-30

I give here a very personal perspective of Bioinformatics and its future, starting by discussing the origin of the term (and area) of bioinformatics and proceeding by trying to foresee the development of related issues, including pattern recognition/data mining, the need to reintegrate biology, the potential of complex networks as a powerful and flexible framework for bioinformatics and the interplay between bio- and neuroinformatics. Human resource formation and market perspective are also addressed. Given the complexity and vastness of these issues and concepts, as well as the limited size of a scientific article and finite patience of the reader, these perspectives are surely incomplete and biased. However, it is expected that some of the questions and trends that are identified will motivate discussions during the IcoBiCoBi round table (with the same name as this article) and perhaps provide a more ample perspective among the participants of that conference and the readers of this text.

Fast Breeder Reactors in Sweden: Vision and Reality.

PubMed

Fjaestad, Maja

2015-01-01

The fast breeder is a type of nuclear reactor that aroused much attention in the 1950s and '60s. Its ability to produce more nuclear fuel than it consumes offered promises of cheap and reliable energy. Sweden had advanced plans for a nuclear breeder program, but canceled them in the middle of the 1970s with the rise of nuclear skepticism. The article investigates the nuclear breeder as a technological vision. The nuclear breeder reactor is an example of a technological future that did not meet its industrial expectations. But that does not change the fact that the breeder was an influential technology. Decisions about the contemporary reactors were taken with the idea that in a foreseeable future they would be replaced with the efficient breeder. The article argues that general themes in the history of the breeder reactor can deepen our understanding of the mechanisms behind technological change.

Minimally invasive abdominal surgery: lux et veritas past, present, and future.

PubMed

Harrell, Andrew G; Heniford, B Todd

2005-08-01

Laparoscopic surgery has developed out of multiple technology innovations and the desire to see beyond the confines of the human body. As the instrumentation became more advanced, the application of this technique followed. By revisiting the historical developments that now define laparoscopic surgery, we can possibly foresee its future. A Medline search was performed of all the English-language literature. Further references were obtained through cross-referencing the bibliography cited in each work and using books from the authors' collection. Minimally invasive surgery is becoming important in almost every facet of abdominal surgery. Optical improvements, miniaturization, and robotic technology continue to define the frontier of minimally invasive surgery. Endoluminal resection surgery, image-guided surgical navigation, and remotely controlled robotics are not far from becoming reality. These and advances yet to be described will change laparoscopic surgery just as the electric light bulb did over 100 years ago.

Variations in the susceptibility to landslides, as a consequence of land cover changes: A look to the past, and another towards the future.

PubMed

Pisano, L; Zumpano, V; Malek, Ž; Rosskopf, C M; Parise, M

2017-12-01

Land cover is one of the most important conditioning factors in landslide susceptibility analysis. Usually it is considered as a static factor, but it has proven to be dynamic, with changes occurring even in few decades. In this work the influence of land cover changes on landslide susceptibility are analyzed for the past and for future scenarios. For the application, an area representative of the hilly-low mountain sectors of the Italian Southern Apennines was chosen (Rivo basin, in Molise Region). With this purpose landslide inventories and land cover maps were produced for the years 1954, 1981 and 2007. Two alternative future scenarios were created for 2050, one which follows the past trend (2050-trend), and another one more extreme, foreseeing a decrease of forested and cultivated areas (2050-alternative). The landslide susceptibility analysis was performed using the Spatial Multi-Criteria Evaluation method for different time steps, investigating changes to susceptibility over time. The results show that environmental dynamics, such as land cover change, affect slope stability in time. In fact there is a decrease of susceptibility in the past and in the future 2050-trend scenario. This is due to the increase of forest or cultivated areas, that is probably determined by a better land management, water and soil control respect to other land cover types such as shrubland, pasture or bareland. Conversely the results revealed by the alternative scenario (2050-alternative), show how the decrease in forest and cultivated areas leads to an increase in landslide susceptibility. This can be related to the assumed worst climatic condition leading to a minor agricultural activity and lower extension of forested areas, possibly associated also to the effects of forest fires. The results suggest that conscious landscape management might contribute to determine a significant reduction in landslide susceptibility. Copyright © 2017 Elsevier B.V. All rights reserved.

Structural Constraints On The Spatial Distribution of Aftershocks

NASA Astrophysics Data System (ADS)

McCloskey, J.; Nalbant, S. S.; Steacy, S.; Nostro, C.; Scotti, O.; Baumont, D.

Real-time, forward modelling of spatial distributions of potentially damaging after- shocks by calculating stress perturbations due to large earthquakes may produce so- cially useful, time- dependent hazard estimates in the foreseeable future. Such calcula- tions, however, rely on the resolution of a stress perturbation tensor (SPT) onto planes whose geometry is unknown and decisions as to the orientations of these planes have a first order effect on the geometry of the resulting hazard distributions. Commonly, these decisions are based on the assumption that structures optimally oriented for fail- ure in the regional stress field, exist everywhere and stress maps are produced by resolving onto these orientations. Here we investigate this proposition using a 3D cal- culation for the optimally oriented planes (OOPs) for the 1992 Landers earthquake (M = 7.3). We examine the encouraged mechanisms as a function of location and show that enhancement for failure exists over a much wider area than in the equivalent, and more usual, 2.5D calculations. Mechanisms predicted in these areas are not consistent with the local structural geology, however, and corresponding aftershocks are gener- ally not observed. We argue that best hazard estimates will result from geometrically restricted versions of the OOP concept in which observed structure constrains possible orientations for failure.

Research on the drying kinetics of household food waste for the development and optimization of domestic waste drying technique.

PubMed

Sotiropoulos, A; Malamis, D; Michailidis, P; Krokida, M; Loizidou, M

2016-01-01

Domestic food waste drying foresees the significant reduction of household food waste mass through the hygienic removal of its moisture content at source. In this manuscript, a new approach for the development and optimization of an innovative household waste dryer for the effective dehydration of food waste at source is presented. Food waste samples were dehydrated with the use of the heated air-drying technique under different air-drying conditions, namely air temperature and air velocity, in order to investigate their drying kinetics. Different thin-layer drying models have been applied, in which the drying constant is a function of the process variables. The Midilli model demonstrated the best performance in fitting the experimental data in all tested samples, whereas it was found that food waste drying is greatly affected by temperature and to a smaller scale by air velocity. Due to the increased moisture content of food waste, an appropriate configuration of the drying process variables can lead to a total reduction of its mass by 87% w/w, thus achieving a sustainable residence time and energy consumption level. Thus, the development of a domestic waste dryer can be proved to be economically and environmentally viable in the future.

Antibiotic alternatives: the substitution of antibiotics in animal husbandry?

PubMed Central

Cheng, Guyue; Hao, Haihong; Xie, Shuyu; Wang, Xu; Dai, Menghong; Huang, Lingli; Yuan, Zonghui

2014-01-01

It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-animal feeds to prevent animals from diseases and to improve production performance in modern animal husbandry. In the meantime, concerns over the increasing emergence of antibiotic-resistant bacteria due to the unreasonable use of antibiotics and an appearance of less novelty antibiotics have prompted efforts to develop so-called alternatives to antibiotics. Whether or not the alternatives could really replace antibiotics remains a controversial issue. This review summarizes recent development and perspectives of alternatives to antibiotics. The mechanism of actions, applications, and prospectives of the alternatives such as immunity modulating agents, bacteriophages and their lysins, antimicrobial peptides, pro-, pre-, and synbiotics, plant extracts, inhibitors targeting pathogenicity (bacterial quorum sensing, biofilm, and virulence), and feeding enzymes are thoroughly discussed. Lastly, the feasibility of alternatives to antibiotics is deeply analyzed. It is hard to conclude that the alternatives might substitute antibiotics in veterinary medicine in the foreseeable future. At the present time, prudent use of antibiotics and the establishment of scientific monitoring systems are the best and fastest way to limit the adverse effects of the abuse of antibiotics and to ensure the safety of animal-derived food and environment. PMID:24860564

Making connections for life: an in vivo map of the yeast interactome.

PubMed

Kast, Juergen

2008-10-01

Proteins are the true workhorses of any cell. To carry out specific tasks, they frequently bind other molecules in their surroundings. Due to their structural complexity and flexibility, the most diverse array of interactions is seen with other proteins. The different geometries and affinities available for such interactions typically bestow specific functions on proteins. Having available a map of protein-protein interactions is therefore of enormous importance for any researcher interested in gaining insight into biological systems at the level of cells and organisms. In a recent report, a novel approach has been employed that relies on the spontaneous folding of complementary enzyme fragments fused to two different proteins to test whether these interact in their actual cellular context [Tarassov et al., Science 320, 1465-1470 (2008)]. Genome-wide application of this protein-fragment complementation assay has resulted in the first map of the in vivo interactome of Saccharomyces cerevisiae. The current data show striking similarities but also significant differences to those obtained using other large-scale approaches for the same task. This warrants a general discussion of the current state of affairs of protein-protein interaction studies and foreseeable future trends, highlighting their significance for a variety of applications and their potential to revolutionize our understanding of the architecture and dynamics of biological systems.

Making connections for life: an in vivo map of the yeast interactome

PubMed Central

Kast, Juergen

2008-01-01

Proteins are the true workhorses of any cell. To carry out specific tasks, they frequently bind other molecules in their surroundings. Due to their structural complexity and flexibility, the most diverse array of interactions is seen with other proteins. The different geometries and affinities available for such interactions typically bestow specific functions on proteins. Having available a map of protein–protein interactions is therefore of enormous importance for any researcher interested in gaining insight into biological systems at the level of cells and organisms. In a recent report, a novel approach has been employed that relies on the spontaneous folding of complementary enzyme fragments fused to two different proteins to test whether these interact in their actual cellular context [Tarassov et al., Science 320, 1465–1470 (2008)]. Genome-wide application of this protein-fragment complementation assay has resulted in the first map of the in vivo interactome of Saccharomyces cerevisiae. The current data show striking similarities but also significant differences to those obtained using other large-scale approaches for the same task. This warrants a general discussion of the current state of affairs of protein–protein interaction studies and foreseeable future trends, highlighting their significance for a variety of applications and their potential to revolutionize our understanding of the architecture and dynamics of biological systems. PMID:19404434

Silicon photonic Mach Zehnder modulators for next-generation short-reach optical communication networks

NASA Astrophysics Data System (ADS)

Lacava, C.; Liu, Z.; Thomson, D.; Ke, Li; Fedeli, J. M.; Richardson, D. J.; Reed, G. T.; Petropoulos, P.

2016-02-01

Communication traffic grows relentlessly in today's networks, and with ever more machines connected to the network, this trend is set to continue for the foreseeable future. It is widely accepted that increasingly faster communications are required at the point of the end users, and consequently optical transmission plays a progressively greater role even in short- and medium-reach networks. Silicon photonic technologies are becoming increasingly attractive for such networks, due to their potential for low cost, energetically efficient, high-speed optical components. A representative example is the silicon-based optical modulator, which has been actively studied. Researchers have demonstrated silicon modulators in different types of structures, such as ring resonators or slow light based devices. These approaches have shown remarkably good performance in terms of modulation efficiency, however their operation could be severely affected by temperature drifts or fabrication errors. Mach-Zehnder modulators (MZM), on the other hand, show good performance and resilience to different environmental conditions. In this paper we present a CMOS-compatible compact silicon MZM. We study the application of the modulator to short-reach interconnects by realizing data modulation using some relevant advanced modulation formats, such as 4-level Pulse Amplitude Modulation (PAM-4) and Discrete Multi-Tone (DMT) modulation and compare the performance of the different systems in transmission.

[The role of neurotrophic factors in regeneration of the nervous system].

PubMed

Machaliński, Bogusław; Lażewski-Banaszak, Piotr; Dąbkowska, Elżbieta; Paczkowska, Edyta; Gołąb-Janowska, Monika; Nowacki, Przemysław

2012-01-01

Neurotrophic factors regulate survival, development, and function of nervous tissue. They act via two different classes of receptors and activation of various signaling pathways in the target cells. Illumination of their physiological role in the maintenance of central nervous system homeostasis as well as regeneration of damaged tissue have ignited expectations to heal neurodegenerative diseases, including amyotrophic late-ral sclerosis and Parkinson disease. Advances in pharmaco-therapy, gene therapy, and stem cell biology have enabled development of novel therapies with application of regenerating cell transplantation. In the foreseeable future, it may lead to the establishment of safe and effective ways of treatment of these severe and currently incurable diseases.

Space and the Third Offset Symposium - Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bahney, B.

The Third Offset Workshop explored the nature of the challenges and opportunities facing the United States as it is increasingly forced to integrate space into defense strategy as well as deterrence and strategic stability frameworks. Participants broadly agreed that Washington’s deep ties to allies and partners, as well as its history of leveraging an innovative U.S private sector, will be enduring competitive advantages against potential rivals into the foreseeable future. Yet panelists also highlighted key challenges from Russia and China’s rapid integration of space capabilities into conventional and nuclear warfighting, the pronounced growth in Chinese and Russian counterspace capabilities, andmore » tensions in the U.S.-Russia relationship.« less

The role of the deep space network's frequency and timing system in the detection of gravitational waves

NASA Technical Reports Server (NTRS)

Mankins, J. C.

1982-01-01

A review of the Deep Space Network's (DSN) use of precision Doppler-tracking of deep space vehicles is presented. The review emphasizes operational and configurational aspects and considers: the projected configuration of the DSN's frequency and timing system; the environment within the DSN provided by the precision atomic standards within the frequency and timing system--both current and projected; and the general requirements placed on the DSN and the frequency and timing system for both the baseline and the nominal gravitational wave experiments. A comment is made concerning the current probability that such an experiment will be carried out in the foreseeable future.

Iron and steel recycling in the United States in 1998

USGS Publications Warehouse

Fenton, Michael D.

2001-01-01

Consumption of iron and steel scrap and the health of the scrap industry depend directly on the health of the steelmaking industry. The United States, as well as most of the world, is expected to consume increasing amounts of scrap as a steadily increasing population demands more steel products. World resources of scrap should be sufficient for the foreseeable future. An estimated 75 million metric tons (Mt) of scrap was generated during 1998 in the United States, and 35 Mt of old scrap and 18 Mt of new scrap was consumed. The recycling efficiency was calculated to be 52%, and the recycling rate was found to be 41%. (See appendix for definitions.)

Mineral supply for sustainable development requires resource governance.

PubMed

Ali, Saleem H; Giurco, Damien; Arndt, Nicholas; Nickless, Edmund; Brown, Graham; Demetriades, Alecos; Durrheim, Ray; Enriquez, Maria Amélia; Kinnaird, Judith; Littleboy, Anna; Meinert, Lawrence D; Oberhänsli, Roland; Salem, Janet; Schodde, Richard; Schneider, Gabi; Vidal, Olivier; Yakovleva, Natalia

2017-03-15

Successful delivery of the United Nations sustainable development goals and implementation of the Paris Agreement requires technologies that utilize a wide range of minerals in vast quantities. Metal recycling and technological change will contribute to sustaining supply, but mining must continue and grow for the foreseeable future to ensure that such minerals remain available to industry. New links are needed between existing institutional frameworks to oversee responsible sourcing of minerals, trajectories for mineral exploration, environmental practices, and consumer awareness of the effects of consumption. Here we present, through analysis of a comprehensive set of data and demand forecasts, an interdisciplinary perspective on how best to ensure ecologically viable continuity of global mineral supply over the coming decades.

Modelling of corruption repression by Komisi Pemberantasan Korupsi in Indonesia

NASA Astrophysics Data System (ADS)

Nugraha, Muhammad Ridwan Reza; Nuraini, Nuning

2017-03-01

Based on data from transparency.org, in 2015 Indonesia was ranked 88 out of 168 most corrupt countries in the world, with a score of 36 (high corruption levels 0 - 100 free of corruption). Scores of corruption in Indonesia increased from 32 to 36 since 2012 until 2015. Since 2002, the eradication of corruption in Indonesia conducted by Komisi Pemberantasan Korupsi. The number of legal actions undertaken by the Commission since 2002 to 2015 increased. In the mathematical model, we want to know the tendency of many legal actions carried out by the Commission for the foreseeable future. By knowing these trends, we can take a variety of strategies that can make Indonesia free from corruption.

Ultra high-definition video: convergence toward 100Gbps and beyond for digital A/V connectivity with fiber optics

NASA Astrophysics Data System (ADS)

Parekh, Devang; Nguyen, Nguyen X.

2018-02-01

The recent advent of Ultra-high-definition television (also known as Ultra HD television, Ultra HD, UHDTV, UHD and Super Hi-Vision) has accelerated a demand for a Fiber-in-the-Premises video communication (VCOM) solution that converges toward 100Gbps and Beyond. Hybrid Active-Optical-Cables (AOC) is a holistic connectivity platform well suited for this "The Last Yard" connectivity; as it combines both copper and fiber optics to deliver a high data-rate and power transmission needed. While technically feasible yet challenging to manufacture, hybrid-AOC could be a holygrail fiber-optics solution that dwarfs the volume of both telecom and datacom connection in the foreseeable future.

Managing in turbulent times: issues and challenges in health care mergers and acquisitions.

PubMed

Jones, S A

1999-09-01

The environment of the health care system in the present and foreseeable future has been described as a revolution whose impetus comes from Wall Street. The new system of health care is characterized by mergers, acquisitions, and joint ventures. For-profit conversions and mergers of religious and secular organizations were almost unheard of before the last decade. The challenges facing nursing leadership in these turbulent times are (1) dealing with the human dynamics associated with creating new organizational cultures, (2) shifting focus away from event-driven cost avoidance and protecting institutional assets, and (3) shifting focus toward stewardship of community resources and nursing practice beyond institutional boundaries.

[The need for experiments using primates from a scientific point of view].

PubMed

Kaup, F J

2007-03-01

Concerning the public discussion on animal experiments using primates, various research fields are demonstrated where non-human primates are necessary for certain scientific reasons at this time. Non-human Primates are used in Germany mainly in regulatory toxicology and pharmaceutical safety studies.A small amount is disposed in different fields of biological or biomedical basic research. This includes in particular neurosciences and infection research. 2006 New and Old World monkeys were needed in Germany in 2005. No chimpanzees are used anymore as laboratory animals in Germany since many years. Several examples are presented to demonstrate that certain research fields need non-human primates as laboratory animals in the foreseeable future.

Mineral supply for sustainable development requires resource governance

USGS Publications Warehouse

Ali, Saleem H.; Giurco, Damien; Arndt, Nicholas; Nickless, Edmund; Brown, Graham; Demetriades, Alecos; Durrheim, Ray; Enriquez, Maria Amélia; Kinnaird, Judith; Littleboy, Anna; Meinert, Lawrence D.; Oberhänsli, Roland; Salem, Janet; Schodde, Richard; Schneider, Gabi; Vidal, Olivier; Yakovleva, Natalia

2017-01-01

Successful delivery of the United Nations sustainable development goals and implementation of the Paris Agreement requires technologies that utilize a wide range of minerals in vast quantities. Metal recycling and technological change will contribute to sustaining supply, but mining must continue and grow for the foreseeable future to ensure that such minerals remain available to industry. New links are needed between existing institutional frameworks to oversee responsible sourcing of minerals, trajectories for mineral exploration, environmental practices, and consumer awareness of the effects of consumption. Here we present, through analysis of a comprehensive set of data and demand forecasts, an interdisciplinary perspective on how best to ensure ecologically viable continuity of global mineral supply over the coming decades.

Mineral supply for sustainable development requires resource governance

NASA Astrophysics Data System (ADS)

Ali, Saleem H.; Giurco, Damien; Arndt, Nicholas; Nickless, Edmund; Brown, Graham; Demetriades, Alecos; Durrheim, Ray; Enriquez, Maria Amélia; Kinnaird, Judith; Littleboy, Anna; Meinert, Lawrence D.; Oberhänsli, Roland; Salem, Janet; Schodde, Richard; Schneider, Gabi; Vidal, Olivier; Yakovleva, Natalia

2017-03-01

Successful delivery of the United Nations sustainable development goals and implementation of the Paris Agreement requires technologies that utilize a wide range of minerals in vast quantities. Metal recycling and technological change will contribute to sustaining supply, but mining must continue and grow for the foreseeable future to ensure that such minerals remain available to industry. New links are needed between existing institutional frameworks to oversee responsible sourcing of minerals, trajectories for mineral exploration, environmental practices, and consumer awareness of the effects of consumption. Here we present, through analysis of a comprehensive set of data and demand forecasts, an interdisciplinary perspective on how best to ensure ecologically viable continuity of global mineral supply over the coming decades.

Infrastructure for large space telescopes

NASA Astrophysics Data System (ADS)

MacEwen, Howard A.; Lillie, Charles F.

2016-10-01

It is generally recognized (e.g., in the National Aeronautics and Space Administration response to recent congressional appropriations) that future space observatories must be serviceable, even if they are orbiting in deep space (e.g., around the Sun-Earth libration point, SEL2). On the basis of this legislation, we believe that budgetary considerations throughout the foreseeable future will require that large, long-lived astrophysics missions must be designed as evolvable semipermanent observatories that will be serviced using an operational, in-space infrastructure. We believe that the development of this infrastructure will include the design and development of a small to mid-sized servicing vehicle (MiniServ) as a key element of an affordable infrastructure for in-space assembly and servicing of future space vehicles. This can be accomplished by the adaptation of technology developed over the past half-century into a vehicle approximately the size of the ascent stage of the Apollo Lunar Module to provide some of the servicing capabilities that will be needed by very large telescopes located in deep space in the near future (2020s and 2030s). We specifically address the need for a detailed study of these servicing requirements and the current proposals for using presently available technologies to provide the appropriate infrastructure.

Biological challenges of true space settlement

NASA Astrophysics Data System (ADS)

Mankins, John C.; Mankins, Willa M.; Walter, Helen

2018-05-01

"Space Settlements" - i.e., permanent human communities beyond Earth's biosphere - have been discussed within the space advocacy community since the 1970s. Now, with the end of the International Space Station (ISS) program fast approaching (planned for 2024-2025) and the advent of low cost Earth-to-orbit (ETO) transportation in the near future, the concept is coming once more into mainstream. Considerable attention has been focused on various issues associated with the engineering and human health considerations of space settlement such as artificial gravity and radiation shielding. However, relatively little attention has been given to the biological implications of a self-sufficient space settlement. Three fundamental questions are explored in this paper: (1) what are the biological "foundations" of truly self-sufficient space settlements in the foreseeable future, (2) what is the minimum scale for such self-sustaining human settlements, and (3) what are the integrated biologically-driven system requirements for such settlements? The paper examines briefly the implications of the answers to these questions in relevant potential settings (including free space, the Moon and Mars). Finally, this paper suggests relevant directions for future research and development in order for such space settlements to become viable in the future.

Activated Carbon Fibers For Gas Storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burchell, Timothy D; Contescu, Cristian I; Gallego, Nidia C

The advantages of Activated Carbon Fibers (ACF) over Granular Activated Carbon (GAC) are reviewed and their relationship to ACF structure and texture are discussed. These advantages make ACF very attractive for gas storage applications. Both adsorbed natural gas (ANG) and hydrogen gas adsorption performance are discussed. The predicted and actual structure and performance of lignin-derived ACF is reviewed. The manufacture and performance of ACF derived monolith for potential automotive natural gas (NG) storage applications is reported Future trends for ACF for gas storage are considered to be positive. The recent improvements in NG extraction coupled with the widespread availability ofmore » NG wells means a relatively inexpensive and abundant NG supply in the foreseeable future. This has rekindled interest in NG powered vehicles. The advantages and benefit of ANG compared to compressed NG offer the promise of accelerated use of ANG as a commuter vehicle fuel. It is to be hoped the current cost hurdle of ACF can be overcome opening ANG applications that take advantage of the favorable properties of ACF versus GAC. Lastly, suggestions are made regarding the direction of future work.« less

3D printing for clinical application in otorhinolaryngology.

PubMed

Zhong, Nongping; Zhao, Xia

2017-12-01

Three-dimensional (3D) printing is a promising technology that can use a patient's image data to create complex and personalized constructs precisely. It has made great progress over the past few decades and has been widely used in medicine including medical modeling, surgical planning, medical education and training, prosthesis and implants. Three-dimensional (3D) bioprinting is a powerful tool that has the potential to fabricate bioengineered constructs of the desired shape layer-by-layer using computer-aided deposition of living cells and biomaterials. Advances in 3D printed implants and future tissue-engineered constructs will bring great progress to the field of otolaryngology. By integrating 3D printing into tissue engineering and materials, it may be possible for otolaryngologists to implant 3D printed functional grafts into patients for reconstruction of a variety of tissue defects in the foreseeable future. In this review, we will introduce the current state of 3D printing technology and highlight the applications of 3D printed prosthesis and implants, 3D printing technology combined with tissue engineering and future directions of bioprinting in the field of otolaryngology.

Animal health aspects of adaptation to climate change: beating the heat and parasites in a warming Europe.

PubMed

Skuce, P J; Morgan, E R; van Dijk, J; Mitchell, M

2013-06-01

Weather patterns in northern European regions have changed noticeably over the past several decades, featuring warmer, wetter weather with more extreme events. The climate is projected to continue on this trajectory for the foreseeable future, even under the most modest warming scenarios. Such changes will have a significant impact on livestock farming, both directly through effects on the animals themselves, and indirectly through changing exposure to pests and pathogens. Adaptation options aimed at taking advantage of new opportunities and/or minimising the risks of negative impacts will, in themselves, have implications for animal health and welfare. In this review, we consider the potential consequences of future intensification of animal production, challenges associated with indoor and outdoor rearing of animals and aspects of animal transportation as key examples. We investigate the direct and indirect effects of climate change on the epidemiology of important livestock pathogens, with a particular focus on parasitic infections, and the likely animal health consequences associated with selected adaptation options. Finally, we attempt to identify key gaps in our knowledge and suggest future research priorities.

Work satisfaction and future career intentions of experienced nurses transitioning to primary health care employment.

PubMed

Ashley, Christine; Peters, Kath; Brown, Angela; Halcomb, Elizabeth

2018-02-12

To explore registered nurses' reflections on transitioning from acute to primary health care employment, and future career intentions. Reforms in primary health care have resulted in increasing demands for a skilled primary health care nursing workforce. To meet shortfalls, acute care nurses are being recruited to primary health care employment, yet little is known about levels of satisfaction and future career intentions. A sequential mixed methods study consisting of a survey and semi-structured interviews with nurses who transition to primary health care. Most reported positive experiences, valuing work/life balance, role diversity and patient/family interactions. Limited orientation and support, loss of acute skills and inequitable remuneration were reported negatively. Many respondents indicated an intention to stay in primary health care (87.3%) and nursing (92.6%) for the foreseeable future, whilst others indicated they may leave primary health care as soon as convenient (29.6%). Our findings provide guidance to managers in seeking strategies to recruit and retain nurses in primary health care employment. To maximize recruitment and retention, managers must consider factors influencing job satisfaction amongst transitioning nurses, and the impact that nurses' past experiences may have on future career intentions in primary health care. © 2018 John Wiley & Sons Ltd.

Oil and gas development footprint in the Piceance Basin, western Colorado

USGS Publications Warehouse

Martinez, Cericia D.; Preston, Todd M.

2018-01-01

Understanding long-term implications of energy development on ecosystem functionrequires establishing regional datasets to quantify past development and determine relationships to predict future development. The Piceance Basin in western Colorado has a history of energy production and development is expected to continue into the foreseeable future due to abundant natural gas resources. To facilitate analyses of regional energy development we digitized all well pads in the Colorado portion of the basin, determined the previous land cover of areas converted to well pads over three time periods (2002–2006, 2007–2011, and 2012–2016), and explored the relationship between number of wells per pad and pad area to model future development. We also calculated the area of pads constructed prior to 2002. Over 21 million m2 has been converted to well pads with approximately 13 million m2 converted since 2002. The largest land conversion since 2002 occurred in shrub/scrub (7.9 million m2), evergreen (2.1 million m2), and deciduous (1.3 million m2) forest environments based on National Land Cover Database classifications. Operational practices have transitioned from single well pads to multi-well pads, increasing the average number of wells per pad from 2.5 prior to 2002, to 9.1 between 2012 and 2016. During the same time period the pad area per well has increased from 2030 m2 to 3504 m2. Kernel density estimation was used to model the relationship between the number of wells per pad and pad area, with these curves exhibiting a lognormal distribution. Therefore, either kernel density estimation or lognormal probability distributions may potentially be used to model land use requirements for future development. Digitized well pad locations in the Piceance Basin contribute to a growing body of spatial data on energy infrastructure and, coupled with study results, will facilitate future regional and national studies assessing the spatial and temporal effects of energy development on ecosystem function.

Threatened and endangered species evaluation for 75 licensed commercial nuclear power generating plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sackschewsky, M.R.

The Endangered Species Act (ESA) of 1973, as amended, and related implementing regulations of the jurisdictional federal agencies, the U.S. Departments of Commerce and Interior, at 50 CFR Part 17. 1, et seq., require that federal agencies ensure that any action authorized, funded, or carried out under their jurisdiction is not likely to jeopardize the continued existence of any threatened or endangered species or result in the destruction or adverse modification of critical habitats for such species. The issuance and maintenance of a federal license, such as a construction permit or operating license issued by the U.S. Nuclear Regulatory Commissionmore » (NRC) for a commercial nuclear power generating facility is a federal action under the jurisdiction of a federal agency, and is therefore subject to the provisions of the ESA. The U.S. Department of the Interior (through the Fish and Wildlife Service), and the U.S. Department of Commerce, share responsibility for administration of the ESA. The National Marine Fisheries Service (NMFS) deals with species that inhabit marine environments and anadromous fish, while the U.S. Fish and Wildlife Service (USFWS) is responsible for terrestrial and freshwater species and migratory birds. A species (or other distinct taxonomic unit such as subspecies, variety, and for vertebrates, distinct population units) may be classified for protection as `endangered` when it is in danger of extinction within the foreseeable future throughout all or a significant portion of its range. A `threatened` classification is provided to those animals and plants likely to become endangered within the foreseeable future throughout all or a significant portion of their ranges. As of February 1997, there were about 1067 species listed under the ESA in the United States. Additionally there were approximately 125 species currently proposed for listing as threatened or endangered, and another 183 species considered to be candidates for formal listing proposals.« less

Povidone iodine in wound healing: A review of current concepts and practices.

PubMed

Bigliardi, Paul Lorenz; Alsagoff, Syed Abdul Latiff; El-Kafrawi, Hossam Yehia; Pyon, Jai-Kyong; Wa, Chad Tse Cheuk; Villa, Martin Anthony

2017-08-01

Of the many antimicrobial agents available, iodophore-based formulations such as povidone iodine have remained popular after decades of use for antisepsis and wound healing applications due to their favorable efficacy and tolerability. Povidone iodine's broad spectrum of activity, ability to penetrate biofilms, lack of associated resistance, anti-inflammatory properties, low cytotoxicity and good tolerability have been cited as important factors, and no negative effect on wound healing has been observed in clinical practice. Over the past few decades, numerous reports on the use of povidone iodine have been published, however, many of these studies are of differing design, endpoints, and quality. More recent data clearly supports its use in wound healing. Based on data collected through PubMed using specified search criteria based on above topics and clinical experience of the authors, this article will review preclinical and clinical safety and efficacy data on the use of povidone iodine in wound healing and its implications for the control of infection and inflammation, together with the authors' advice for the successful treatment of acute and chronic wounds. Povidone iodine has many characteristics that position it extraordinarily well for wound healing, including its broad antimicrobial spectrum, lack of resistance, efficacy against biofilms, good tolerability and its effect on excessive inflammation. Due to its rapid, potent, broad-spectrum antimicrobial properties, and favorable risk/benefit profile, povidone iodine is expected to remain a highly effective treatment for acute and chronic wounds in the foreseeable future. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Response of the turbidity maximum zone in the Yangtze River Estuary due to human activities during the dry season.

PubMed

Chen, Xiaofeng; Shen, Zhenyao; Yang, Ye

2016-09-01

The interaction between a river and the sea results in a turbidity maximum zone (TMZ) within the estuary, which has a great impact on the local ecosystem. In the Yangtze River Estuary, the magnitude and extent of the TMZ vary with water discharge. In this study, the cumulative human activity altered the water discharge regime from the river to the estuary. In the post-Three Gorges Dam (TGD) period, water discharge increased by 35.10 % at Datong in February compared with that in the pre-TGD period. The effects of water discharge variation on the characteristics of the TMZ were analyzed during spring and neap tidal periods using the three-dimensional environmental fluid dynamic code (EFDC) model. The area of the TMZ decreased by 3.11 and 17.39 % during neap and spring tides, respectively. In addition, the upper limit of the TMZ moved 11.68 km seaward during neap tide, whereas the upper limit of the TMZ in the upstream and downstream areas moved seaward 9.65 and 2.34 km, respectively, during spring tide. These findings suggest that the area and location of the TMZ are more sensitive to upstream runoff during spring tide than during neap tide. These changes in the TMZ will impact the biochemical processes in the Yangtze River Estuary. In the foreseeable future, the distribution characteristic of TMZ will inevitably change due to variations in the Yangtze River discharge resulting from new human activities (i.e., new dams), which are being constructed upstream in the Yangtze River system.

Resources and economic growth: the American future--a dialogue. [Debate of geologist, physicist, and systems analyst

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meadows, D.L.; Weinberg, A.M.; Boyd, J.

Geologist James Boyd, physicist Alvin Weinberg, and systems analyst Dennis Meadows participated in a debate at which they forecast the cost and availability of world resources. Highlights of the debate and questions and comments from their audience are presented here. A range of optimism is evident in the predictions. Boyd foresees that energy and resource problems will be solved by technology, while Meadows contends that no solutions are possible until institutional and political constraints are lifted to allow resource development. Weinberg takes a middle view and proposes substitution of new resources for those, like fossil fuels, that are nearing depletion.more » The role of the market system is debated with disagreement over whether energy development should or can respond to a free market--and whether per capita energy consumption will increase or decline with limited economic growth. Policies governing access to fossil fuels and metals in the future are felt to be central to the issue. (DCK)« less

Present and foreseeable future of metabolomics in forensic analysis.

PubMed

Castillo-Peinado, L S; Luque de Castro, M D

2016-06-21

The revulsive publications during the last years on the precariousness of forensic sciences worldwide have promoted the move of major steps towards improvement of this science. One of the steps (viz. a higher involvement of metabolomics in the new era of forensic analysis) deserves to be discussed under different angles. Thus, the characteristics of metabolomics that make it a useful tool in forensic analysis, the aspects in which this omics is so far implicit, but not mentioned in forensic analyses, and how typical forensic parameters such as the post-mortem interval or fingerprints take benefits from metabolomics are critically discussed in this review. The way in which the metabolomics-forensic binomial succeeds when either conventional or less frequent samples are used is highlighted here. Finally, the pillars that should support future developments involving metabolomics and forensic analysis, and the research required for a fruitful in-depth involvement of metabolomics in forensic analysis are critically discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

Educating and Inspiring Young People for the Next Generation of Exploration

NASA Technical Reports Server (NTRS)

Armstrong, Robert C., Jr.

2007-01-01

With the graying of the nation's scientific workforce and the decline in students pursuing science, technological, engineering, and math related-studies, real challenges lie ahead if America is to continue to sustain the Vision for Space Exploration in the foreseeable future. Likewise, challenges exist in the economic arena as the United States seeks to maintain its preeminence among the technological leaders of the world. Currently, less than 6 percent of high school seniors are pursuing engineering degrees, down from 36 percent a decade ago. Today, China produces six times as many engineers as does the United States and Japan, at half our population, develops twice as many engineers. Despite spending more per capita on public education than any other nation, except Switzerland, U.S. students of high school age are failing to compete with many foreign countries. These trends do not bode well for America's future competitiveness in space and other technically driven areas, such as defense.

Industrialization of mAb production technology The bioprocessing industry at a crossroads

PubMed Central

2009-01-01

Manufacturing processes for therapeutic monoclonal antibodies (mAbs) have evolved tremendously since the first licensed mAb product in 1986. The rapid growth in product demand for mAbs triggered parallel efforts to increase production capacity through construction of large bulk manufacturing plants as well as improvements in cell culture processes to raise product titers. This combination has led to an excess of manufacturing capacity, and together with improvements in conventional purification technologies, promises nearly unlimited production capacity in the foreseeable future. The increase in titers has also led to a marked reduction in production costs, which could then become a relatively small fraction of sales price for future products which are sold at prices at or near current levels. The reduction of capacity and cost pressures for current state-of-the-art bulk production processes may shift the focus of process development efforts and have important implications for both plant design and product development strategies for both biopharmaceutical and contract manufacturing companies. PMID:20065641

Urologists on a tightrope--do we have a net?

PubMed

Loughlin, Kevin R

2003-12-01

The purpose of this review is to analyze the current health care environment and its impact on urological practice. The medical and lay literature as it pertains to the socioeconomics of health care was reviewed. Analysis of the political and economic factors that influence the delivery of health care today reveals alarming realities. More than 40 million Americans remain uninsured, and with a retrenched economy that number is likely to increase. Neither government nor the private sector has been either willing or able to address the health care problem in a coherent or comprehensive way. As the population ages, the Medicare and Medicaid programs will become further stressed. Employers are increasingly unwilling to finance the health care expenses of their employees. Academic medical centers are facing unique exigencies that, if left uncorrected, will jeopardize the future training of physicians. In the current environment of a depressed economy, further proposed tax cuts and increased military spending it appears inevitable that the economic restraints on medical care will increase substantially in the foreseeable future.

Human factors/ergonomics as a systems discipline? "The human use of human beings" revisited.

PubMed

Hollnagel, Erik

2014-01-01

Discussions of the possible future of Human factors/ergonomics (HFE) usually take the past for granted in the sense that the future of HFE is assumed to be more of the same. This paper argues that the nature of work in the early 2010s is so different from the nature of work when HFE was formulated 60-70 years ago that a critical reassessment of the basis for HFE is needed. If HFE should be a systems discipline, it should be a soft systems rather than a hard systems discipline. It is not enough for HFE to seek to improve performance and well-being through systems design, since any change to the work environment in principle alters the very basis for the change. Instead HFE should try to anticipate how the nature of work will change so that it can both foresee what work will be and propose what work should be. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Wind tunnel technology for the development of future commercial aircraft

NASA Technical Reports Server (NTRS)

Szodruch, J.

1986-01-01

Requirements for new technologies in the area of civil aircraft design are mainly related to the high cost involved in the purchase of modern, fuel saving aircraft. A second important factor is the long term rise in the price of fuel. The demonstration of the benefits of new technologies, as far as these are related to aerodynamics, will,for the foreseeable future, still be based on wind tunnel measurements. Theoretical computation methods are very successfully used in design work, wing optimization, and an estimation of the Reynolds number effect. However, wind tunnel tests are still needed to verify the feasibility of the considered concepts. Along with other costs, the cost for the wind tunnel tests needed for the development of an aircraft is steadily increasing. The present investigation is concerned with the effect of numerical aerodynamics and civil aircraft technology on the development of wind tunnels. Attention is given to the requirements for the wind tunnel, investigative methods, measurement technology, models, and the relation between wind tunnel experiments and theoretical methods.

Grave's disease 1835-2002.

PubMed

Weetman, A P

2003-01-01

This brief review describes the history of Graves' disease, starting with the original descriptions by Parry, Graves and von Basedow. The true aetiology of the disorder was uncovered in the 1950s and 1960s, based on the search for a novel thyroid stimulator which turned out to be an immunoglobulin G autoantibody. Assays for these thyroid stimulatory antibodies have been continually refined and their epitopes on the thyroid stimulating hormone receptor are increasingly well characterized. We also understand far more about the genetic and environmental susceptibility factors that predispose to disease, and even thyroid-associated ophthalmopathy has now been better defined as primarily a T-cell-mediated disease resulting from cytokine stimulation of orbital fibroblasts. These advances should improve treatment options for Graves' disease in the foreseeable future.

Synchrotron Radiation from Outer Space and the Chandra X-Ray Observatory

NASA Technical Reports Server (NTRS)

Weisskopf, M. C.

2006-01-01

The universe provides numerous extremely interesting astrophysical sources of synchrotron X radiation. The Chandra X-ray Observatory and other X-ray missions provide powerful probes of these and other cosmic X-ray sources. Chandra is the X-ray component of NASA's Great Observatory Program which also includes the Hubble Space telescope, the Spitzer Infrared Telescope Facility, and the now defunct Compton Gamma-Ray Observatory. The Chandra X-Ray Observatory provides the best angular resolution (sub-arcsecond) of any previous, current, or planned (for the foreseeable near future) space-based X-ray instrumentation. We present here a brief overview of the technical capability of this X-Ray observatory and some of the remarkable discoveries involving cosmic synchrotron sources.

Object classification and outliers analysis in the forthcoming Gaia mission

NASA Astrophysics Data System (ADS)

Ordóñez-Blanco, D.; Arcay, B.; Dafonte, C.; Manteiga, M.; Ulla, A.

2010-12-01

Astrophysics is evolving towards the rational optimization of costly observational material by the intelligent exploitation of large astronomical databases from both terrestrial telescopes and spatial mission archives. However, there has been relatively little advance in the development of highly scalable data exploitation and analysis tools needed to generate the scientific returns from these large and expensively obtained datasets. Among the upcoming projects of astronomical instrumentation, Gaia is the next cornerstone ESA mission. The Gaia survey foresees the creation of a data archive and its future exploitation with automated or semi-automated analysis tools. This work reviews some of the work that is being developed by the Gaia Data Processing and Analysis Consortium for the object classification and analysis of outliers in the forthcoming mission.

Guns, Mental Illness, and the Law: Introduction to This Issue.

PubMed

Swanson, Jeffrey W; Felthous, Alan R

2015-06-01

Firearm violence is a top-tier public health problem in the U.S., killing 33,563 and injuring an additional 81,396 people in 2012 (Centers for Disease Control and Prevention, CDC, ). Given constitutional protection and the cultural entrenchment of private gun ownership in the U.S., it is likely that guns will remain widely accessible--and largely unrestricted--for the foreseeable future. Therefore, most policies and laws intended to reduce firearm violence focus selectively on preventing "dangerous people" from having access to guns. That is a formidable challenge. How do we think productively about guns and mental illness in this context, and about the role of law in lessening the toll of gun violence? Copyright © 2015 John Wiley & Sons, Ltd.

Man-made Boards Technology Trends based on TRIZ Evolution Theory

NASA Astrophysics Data System (ADS)

Yu, Huiling; Fan, Delin

China is one of the world's largest manufacturers and consumers of man-made board applications. A systematic and efficient method of foreseeing future technology trends and their evolutionary potentials is a key task that can help companies guide their planning and allocate their resources. Application of the law of evolution with a S-shaped curve could contribute essentially to the accuracy of the long-term forecast. This research seeks to determine the current stage and the position on the S-curve of man-made board technology in China on the TRIZ evolution theo ryand introduce a methodology which combines patent analysis and technology life cycle forecasting to find a niche space of man-made technology development in China.

Coping with changing controlled vocabularies.

PubMed Central

Cimino, J. J.; Clayton, P. D.

1994-01-01

For the foreseeable future, controlled medical vocabularies will be in a constant state of development, expansion and refinement. Changes in controlled vocabularies must be reconciled with historical patient information which is coded using those vocabularies and stored in clinical databases. This paper explores the kinds of changes that can occur in controlled vocabularies, including adding terms (simple additions, refinements, redundancy and disambiguation), deleting terms, changing terms (major and minor name changes), and other special situations (obsolescence, discovering redundancy, and precoordination). Examples are drawn from actual changes appearing in the 1993 update to the International Classification of Diseases (ICD9-CM). The methods being used at Columbia-Presbyterian Medical Center to reconcile its Medical Entities Dictionary and its clinical database are discussed. PMID:7949906

Bio-recognition and detection using liquid crystals.

PubMed

Hussain, A; Pina, A S; Roque, A C A

2009-09-15

Liquid crystals (LCs) are used extensively by the electronics industry as display devices. Advances in the understanding of the liquid crystalline phase and the chemistry therein lead to the development of LC exhibiting faster switching speed with greater twist angle. This in turn lead to the emergence of liquid crystal displays, rendering dial-and-needle based displays (such as those used in various meters) and cathode ray tubes obsolete. In this article, we review the history of LC and their emergence as an invaluable material for display devices and the more recent discovery of their use as sensing elements in biosensors. This new application of LC as tools in the development of fast and simple biosensors is envisaged to gain more importance in the foreseeable future.

Treatment of phosphate retention: The earlier the better?

PubMed Central

Biggar, Patrick; Fung, Samuel K.S.; Ketteler, Markus

2014-01-01

Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20th century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack indisputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4. PMID:26877944

Next generation DRM: cryptography or forensics?

NASA Astrophysics Data System (ADS)

Robert, Arnaud

2009-02-01

Current content protection systems rely primarily on applied cryptographic techniques but there is an increased use of forensic solutions in images, music and video distribution alike. The two approaches differ significantly, both in terms of technology and in terms of strategy, and thus it begs the question: will one approach take over in the long run, and if so which one? Discussing the evolution of both cryptographic and forensic solutions, we conclude that neither approach is ideal for all constituents, and that in the video space at least they will continue to co-exist for the foreseeable future - even if this may not be the case for other media types. We also analyze shortcomings of these approaches, and suggest that new solutions are necessary in this still emerging marketplace.

The existential cost of economic insecurity: Threatened financial security undercuts meaning.

PubMed

Abeyta, Andrew A; Routledge, Clay; Kersten, Michael; Cox, Cathy R

2017-01-01

Financial security (i.e., a person's sense that they can afford the things they need now and in the foreseeable future) contributes to psychological health and well-being. In the present research, we explored the implications of financial security for perceptions of meaning in life. In Study 1, we found that perceptions of financial insecurity predicted perceptions of meaning in life above and beyond income. Further, income only predicted perceptions of meaning to the extent that it was associated with reduced financial insecurity. In Studies 2 and 3, we found that financial security threats undermined perceptions of meaning in life. Taken together, these studies suggest that maintaining financial security is important for a sense of meaning in life.

Positrons from quantum evaporation of primordial black-holes

NASA Technical Reports Server (NTRS)

Durouchoux, P.; Wallyn, P.; Dubus, G.

1997-01-01

The unconfirmed prediction of quantum evaporation of primordial black holes (PBHs) is considered together with the related unanswered questions of whether PBHs ever existed and whether any could still exist. The behavior of the positrons from PHBs is modeled in relation to three facts. Firstly, the integrated emitted number spectrum of positrons is six to eight times larger than that of photons. Secondly, positrons emitted from PBHs lose energy and annihilate, producing a prominent line at 511 keV which is redshifted by the expansion of the universe. Thirdly, these photons may be detectable in the X-ray and low gamma ray energy ranges. The model predicts a flux which is significantly inferior to the instrument sensitivities of the foreseeable future.

Realtime multi-plot graphics system

NASA Technical Reports Server (NTRS)

Shipkowski, Michael S.

1990-01-01

The increased complexity of test operations and customer requirements at Langley Research Center's National Transonic Facility (NTF) surpassed the capabilities of the initial realtime graphics system. The analysis of existing hardware and software and the enhancements made to develop a new realtime graphics system are described. The result of this effort is a cost effective system, based on hardware already in place, that support high speed, high resolution, generation and display of multiple realtime plots. The enhanced graphics system (EGS) meets the current and foreseeable future realtime graphics requirements of the NTF. While this system was developed to support wind tunnel operations, the overall design and capability of the system is applicable to other realtime data acquisition systems that have realtime plot requirements.

Opportunities for development of advanced large cargo aircraft

NASA Technical Reports Server (NTRS)

Whitehead, A. H., Jr.

1976-01-01

A critical review of the history, current state of the art, and future prospects for cargo aircraft systems indicates that three of the major advantages of air cargo are rapid delivery, ability to bridge geographical boundaries, and capability to provide a flexible market response. Foreseeable advances in large aircraft development offer even greater profit potential by increasing the payload ton-miles per pound of fuel. Intermodal containers and handling systems and computerized control and billing may be key ingredients. Details of a NASA program for large aircraft systems technology are outlined, which includes systems studies, research and technology investigations, and determination of the need for critical flight experiments. Innovative advanced technologies and configuration concepts are discussed. Numerous illustrations supplement the text.

Long-range consequences of interplanetary collisions

NASA Technical Reports Server (NTRS)

Sagan, Carl; Ostro, Steven J.

1994-01-01

As Comet Shoemaker-Levy 9 races toward its mid-July collision with the planet Jupiter, considerable public attention is focused on catastrophic impacts with the Earth -- in the past and in the future. In recent years calls have been made to develop technologies that could deflect any asteroid or comet on a collision course. Careful consideration must be given to the nature and time scale of the risk and to the cost-effectiveness and possible problems in the suggested solutions. Risk assessment, threat removal, and resources misuse are examined. The greatest concern is to have a poorly informed public -- exerting pressure for means to mitigate even non-existent threats. The only foreseeable solution is a combination of accurate orbit estimation, realistic threat assessment, and effective public education.

Availability of quality vaccines: policies of a non-government organization.

PubMed

Poore, P

1992-01-01

The availability of vaccines, or any other health service, depends upon, first, the existence of a reliable system of delivery, and the effective management of this system to reach the target population and, second, the acceptance by parents or guardians of the value of the vaccine in preventing death and disability in young children and their mothers. This system must be fully funded and resourced for the foreseeable future if the service is to be sustainable. Today the major obstacles to effective immunization of young children in developing countries is the inadequate, insecure and unpredictable availability of funds and their management. Unless these problems are addressed and solved, the immunization targets set by the World Health Assembly (WHA) will not be met.

Capsule endoscopy of the future: What’s on the horizon?

PubMed Central

Slawinski, Piotr R; Obstein, Keith L; Valdastri, Pietro

2015-01-01

Capsule endoscopes have evolved from passively moving diagnostic devices to actively moving systems with potential therapeutic capability. In this review, we will discuss the state of the art, define the current shortcomings of capsule endoscopy, and address research areas that aim to overcome said shortcomings. Developments in capsule mobility schemes are emphasized in this text, with magnetic actuation being the most promising endeavor. Research groups are working to integrate sensor data and fuse it with robotic control to outperform today’s standard invasive procedures, but in a less intrusive manner. With recent advances in areas such as mobility, drug delivery, and therapeutics, we foresee a translation of interventional capsule technology from the bench-top to the clinical setting within the next 10 years. PMID:26457013

It is hard to learn how gravity and electromagnetism couple

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu Yizen; Jacobs, David M.; Ng Yifung

2010-09-15

We construct the most general effective Lagrangian coupling gravity and electromagnetism up to mass dimension 6 by enumerating all possible nonminimal coupling terms respecting both diffeomorphism and gauge invariance. In all, there are only two unique terms after field redefinitions: one is known to arise from loop effects in QED, while the other is a parity-violating term which may be generated by weak interactions within the standard model of particle physics. We show that neither the cosmological propagation of light nor, contrary to earlier claims, solar system tests of general relativity are useful probes of these terms. These nonminimal couplingsmore » of gravity and electromagnetism may remain a mystery for the foreseeable future.« less

Constructing Model of Relationship among Behaviors and Injuries to Products Based on Large Scale Text Data on Injuries

NASA Astrophysics Data System (ADS)

Nomori, Koji; Kitamura, Koji; Motomura, Yoichi; Nishida, Yoshifumi; Yamanaka, Tatsuhiro; Komatsubara, Akinori

In Japan, childhood injury prevention is urgent issue. Safety measures through creating knowledge of injury data are essential for preventing childhood injuries. Especially the injury prevention approach by product modification is very important. The risk assessment is one of the most fundamental methods to design safety products. The conventional risk assessment has been carried out subjectively because product makers have poor data on injuries. This paper deals with evidence-based risk assessment, in which artificial intelligence technologies are strongly needed. This paper describes a new method of foreseeing usage of products, which is the first step of the evidence-based risk assessment, and presents a retrieval system of injury data. The system enables a product designer to foresee how children use a product and which types of injuries occur due to the product in daily environment. The developed system consists of large scale injury data, text mining technology and probabilistic modeling technology. Large scale text data on childhood injuries was collected from medical institutions by an injury surveillance system. Types of behaviors to a product were derived from the injury text data using text mining technology. The relationship among products, types of behaviors, types of injuries and characteristics of children was modeled by Bayesian Network. The fundamental functions of the developed system and examples of new findings obtained by the system are reported in this paper.

Species and gamete-specific fertilization success of two sea urchins under near future levels of pCO2

NASA Astrophysics Data System (ADS)

Sung, Chan-Gyung; Kim, Tae Won; Park, Young-Gyu; Kang, Seong-Gil; Inaba, Kazuo; Shiba, Kogiku; Choi, Tae Seob; Moon, Seong-Dae; Litvin, Steve; Lee, Kyu-Tae; Lee, Jung-Suk

2014-09-01

Since the Industrial Revolution, rising atmospheric CO2 concentration has driven an increase in the partial pressure of CO2 in seawater (pCO2), thus lowering ocean pH. We examined the separate effects of exposure of gametes to elevated pCO2 and low pH on fertilization success of the sea urchin Strongylocentrotus nudus. Sperm and eggs were independently exposed to seawater with pCO2 levels ranging from 380 (pH 7.96-8.3) to 6000 ppmv (pH 7.15-7.20). When sperm were exposed, fertilization rate decreased drastically with increased pCO2, even at a concentration of 450 ppmv (pH range: 7.94 to 7.96). Conversely, fertilization of Hemicentrotus pulcherrimus was not significantly changed even when sperm was exposed to pCO2 concentrations as high as 750 ppmv. Exposure of S. nudus eggs to seawater with high pCO2 did not affect fertilization success, suggesting that the effect of increased pCO2 on sperm is responsible for reduced fertilization success. Surprisingly, this result was not related to sperm motility, which was insensitive to pCO2. When seawater was acidified using HCl, leaving pCO2 constant, fertilization success in S. nudus remained high (> 80%) until pH decreased to 7.3. While further studies are required to elucidate the physiological mechanism by which elevated pCO2 impairs sperm and reduces S. nudus fertilization, this study suggests that in the foreseeable future, sea urchin survival may be threatened due to lower fertilization success driven by elevated pCO2 rather than by decreased pH in seawater.

The burden of lung cancer in Latin-America and challenges in the access to genomic profiling, immunotherapy and targeted treatments.

PubMed

Raez, Luis E; Cardona, Andrés F; Santos, Edgardo S; Catoe, Heath; Rolfo, Christian; Lopes, Gilberto; Barrios, Carlos; Mas, Luis A; Vallejos, Carlos; Zatarain-Barrón, Zyanya Lucia; Caglevic, Christian; Arrieta, Oscar

2018-05-01

Lung cancer is a public health problem worldwide and Latin America (LATAM) cannot escape this reality. This malignant disease has not only a high prevalence in the region, but is also the main cause of cancer related deaths, and in other emerging countries, the incidence rates are still on the rise. Interestingly in most LATAM countries, lung cancer mortality has been decreasing in men but not in women, reflecting smoking patterns in countries such as Chile, Bolivia, and Brazil. Despite the fact that these issues are well known to government agencies, physicians and patients in the region, current efforts still fall behind those needed in order to face this problem of epidemic proportions. Tobacco control and smoking cessation are the most important interventions against lung cancer, but even with their optimal implementation (which is far from reality at this time) the number of cases in the foreseeable future would still be significant. Beyond tobacco control, advances in our understanding of the molecular component of lung cancer have resulted in new targeted therapies and immune check point inhibitors, which have improved clinical outcomes but at a considerably higher financial cost. LATAM has not widely and speedily adopted these strategies, including new technology and approved novel drugs, due to a number of facts, and therefore only a dismal proportion of LATAḾs patient population have benefited from these new advances. A keen focus on a heterogeneous education system for caregivers in lung cancer treatment would likely help standardize care and improve future potential gains from domestic research. In this review we discuss the challenges of treatment implementation, focusing on new technologies. Copyright © 2018 Elsevier B.V. All rights reserved.

Water management: Current and future challenges and research directions

NASA Astrophysics Data System (ADS)

Cosgrove, William J.; Loucks, Daniel P.

2015-06-01

Water distinguishes our planet compared to all the others we know about. While the global supply of available freshwater is more than adequate to meet all current and foreseeable water demands, its spatial and temporal distributions are not. There are many regions where our freshwater resources are inadequate to meet domestic, economic development and environmental needs. In such regions, the lack of adequate clean water to meet human drinking water and sanitation needs is indeed a constraint on human health and productivity and hence on economic development as well as on the maintenance of a clean environment and healthy ecosystems. All of us involved in research must find ways to remove these constraints. We face multiple challenges in doing that, especially given a changing and uncertain future climate, and a rapidly growing population that is driving increased social and economic development, globalization, and urbanization. How best to meet these challenges requires research in all aspects of water management. Since 1965, the journal Water Resources Research has played an important role in reporting and disseminating current research related to managing the quantity and quality and cost of this resource. This paper identifies the issues facing water managers today and future research needed to better inform those who strive to create a more sustainable and desirable future.

Challenges and Advances for Genetic Engineering of Non-model Bacteria and Uses in Consolidated Bioprocessing

PubMed Central

Yan, Qiang; Fong, Stephen S.

2017-01-01

Metabolic diversity in microorganisms can provide the basis for creating novel biochemical products. However, most metabolic engineering projects utilize a handful of established model organisms and thus, a challenge for harnessing the potential of novel microbial functions is the ability to either heterologously express novel genes or directly utilize non-model organisms. Genetic manipulation of non-model microorganisms is still challenging due to organism-specific nuances that hinder universal molecular genetic tools and translatable knowledge of intracellular biochemical pathways and regulatory mechanisms. However, in the past several years, unprecedented progress has been made in synthetic biology, molecular genetics tools development, applications of omics data techniques, and computational tools that can aid in developing non-model hosts in a systematic manner. In this review, we focus on concerns and approaches related to working with non-model microorganisms including developing molecular genetics tools such as shuttle vectors, selectable markers, and expression systems. In addition, we will discuss: (1) current techniques in controlling gene expression (transcriptional/translational level), (2) advances in site-specific genome engineering tools [homologous recombination (HR) and clustered regularly interspaced short palindromic repeats (CRISPR)], and (3) advances in genome-scale metabolic models (GSMMs) in guiding design of non-model species. Application of these principles to metabolic engineering strategies for consolidated bioprocessing (CBP) will be discussed along with some brief comments on foreseeable future prospects. PMID:29123506

[Evaluation of therapies in oncology by positron emission tomography: towards therapeutical personalization].

PubMed

Bonardel, G; Vedrine, L; Aupee, O; Gontier, E; Le Garlantezec, P; Soret, M; Foehrenbach, H

2009-02-01

Recently introduced into clinical practice, positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) has proven its utility for diagnosis and staging of malignant diseases on account of its ability for tissue identification. Its utilization is now moving toward the evaluation of anti-tumoral effects of anticancer therapy, because of the correlation between the uptake of a metabolic tracer and malignant cells viability. Metabolic effects of chemotherapy are first observed in cells and this is the explanation for the precocity of scintigraphic visualisation of therapeutic activity. However, monitoring response with FDG-PET requires rigorous method and needs to take into account the limitations of SUV. Moreover, in order to go beyond the limitations of FDG, new tracers are developed and their main indication could be precisely the monitoring of therapy response. The properties of positron emitters allow us to foresee the labelling of the therapeutic molecules themselves in order to try them in vivo before their utilization for a given patient. These prospects are the ground for real treatment personalization in oncology. They open up a wide field of clinical research but the means for image acquisition and radioactive tracers production will be mandatory for anyone who wants to contribute to this work. Due to the current performances of the imaging systems, the critical point will be availability of equipment allowing the designing and synthesis of the radiopharmaceuticals of the future.

Code Blue on Orbit: Treating Cardiac Arrest on the ISS

NASA Technical Reports Server (NTRS)

Bacal, Kira; Redmond, Melissa

2004-01-01

As a result of the Columbia tragedy on February 1,2003, the International Space Station (ISS) crew size has been temporarily reduced from three to two. This change forces adaptations in many operational procedures used by the crew, including medical protocols which were designed for scenarios involving one casualty and two caregivers. The Office of Space Medicine directed that the procedure for the resuscitation of a crewmember in cardiac arrest be rewritten for use by a single care provider. Methods: Adaptation of this procedure made use of current American Heart Association Advanced Cardiac Life Support (ACLS) procedures and reflects necessary compromises between the realities of the operational environment and prompt provision of medical care. Results: Numerous changes were incorporated due to the diminution in available personnel, including substitution of endotracheal rather than intravenous delivery of drugs, more rapid defibrillation, addition of a precordial thump, removal of transcutaneous pacing, streamlining of procedural steps, and clarification of termination criteria. Discussion: The on-orbit care available to the ISS crewmembers is constrained by numerous factors, including crew medical training, minimal medical assets, limited air/ground communication , and a single caregiver for the foreseeable future. All of these combine to make a successful resuscitation unlikely, however, this procedure must ultimately deal with not only the patient's welfare, but also that of the caregiver, the mission, and the program.

[Smallpox is a dormant volcano].

PubMed

L'vov, D K; Zverev, V V; Gintsburg, A L; Marennikova, S S; Pal'tsev, M A

2008-01-01

The presence of rodent-associated natural foci containing at least 6 of the known 11 viruses belonging to the genus Orthopoxvirus (Poxviridae, Chordopoxvirinae) within the equatorial, tropical, subtropical, temperate, and subarctic climatic zones; the increasing aggravation of the monkey pox epidemic situation in equatorial Africa with an increase in human mortality by an average of 9.8% with a possibility of 2 to 8 passages in 30-70% of patients; the possible persistence of a virus in the human cadavers buried in the permafrost of Eurasia and America; bioterrorism threat due to the unaccounted viral reserves persisting somewhere or somebody; no postvaccinal human immunity since vaccination and vaccine manufacture stopped 30 years ago as recommended by the WHO, make the risk of the deteriorating epidemic situation with disastrous effects greater now and in the foreseeable future than it was 20-30 years ago. Health care academic circles and bodies do not know methods for rapid diagnosis in the field conditions of species-specific identification smallpox virus or preventive (low-reactogenic, effective vaccines, and those accessible for mass production) and therapeutic (nontoxic drugs, those satisfactory for mass production, inexpedient, effective ones when orally used) agents. Basic studies of biodiversity, functional properties of viral DNA and proteins, pathogenesis, and evolution are required. Live smallpox virus should be used at certain and particularly final stages for these studies that are of scientific and applied significance.

A compact, portable, re-configurable, and automated system for on-demand pharmaceutical tablet manufacturing.

PubMed

Azad, Mohammad A; Osorio, Juan G; Brancazio, David; Hammersmith, Gregory; Klee, David M; Rapp, Kersten; Myerson, Allan

2018-03-25

Due to the complex nature of the pharmaceutical supply chain, the industry faces several major challenges when it comes to ensuring an adequate supply of quality drug products. These challenges are not only the causes of supply chain disruptions and financial loss, but can also prevent underserved and remote areas from receiving life-saving drugs. As a preliminary demonstration to mitigate all these challenges, at MIT we have developed active pharmaceutical ingredients manufacturing in a miniature platform. However, manufacturing of final oral solid dosage as tablets from drug substances had not been demonstrated. In this study, a compact, portable, re-configurable, and automated tablet manufacturing system, roughly the size of a North American household oven, [72.4 cm (length) × 53.3 cm (width) × 134.6 cm (height)] was designed, built and demonstrated. This miniature system is able to manufacture on-demand tablets from drug crystals on a scale of hundreds to thousands per day. Ibuprofen and Diazepam, each having different drug loading, were manufactured using this miniature system and meet U.S. Pharmacopeia standards. We foresee this flexible, miniature, plug-and-play pharmaceutical solids dosage manufacturing system advancing on-demand ready-to-use pharmaceuticals enabling future treatment of human diseases at the point-of-care. Copyright © 2018 Elsevier B.V. All rights reserved.

Hexadecenoic fatty acid isomers: a chemical biology approach for human plasma biomarker development.

PubMed

Sansone, Anna; Melchiorre, Michele; Chatgilialoglu, Chryssostomos; Ferreri, Carla

2013-11-18

Hexadecenoic fatty acids are monounsaturated lipid components, which are interesting targets of plasma lipidomic studies and biomarker development. The main positional isomers, palmitoleic (9-cis-16:1) and sapienic acids (6-cis-16:1), have an endogenous origin from palmitic acid, the former being recognized as a component of adipose tissue with signaling activity, whereas the latter is mainly reported as a component of sebum. The trans 16:1 isomers are attributed so far to dietary sources of industrial and dairy fats, whereas the endogenous formation due to the free radical-mediated isomerization can represent an emerging, yet unexplored, pathway connected to cellular stress. Herein, we report a chemical biology approach for the development of hexadecenoic fatty acids as plasma biomarkers, with the first synthesis of 6-trans-16:1 and the efficient analytical setup with unambiguous assignment of 16:1 double bond position and geometry, which was applied to human commercial LDL and plasma cholesteryl esters. Sapienic acid was identified together with its geometrical trans isomer for the first time. The quantitation of hexadecenoic fatty acid isomers evidenced their different levels in the two lipid classes and LDL fractions, making us foresee interesting applications to the metabolic evaluation of fatty acid pathways. These findings open new perspectives for plasma lipidomics involving monounsaturated fatty acids, highlighting future developments for their evaluation in different health conditions including free radical stress.

VTE Risk assessment - a prognostic Model: BATER Cohort Study of young women.

PubMed

Heinemann, Lothar Aj; Dominh, Thai; Assmann, Anita; Schramm, Wolfgang; Schürmann, Rolf; Hilpert, Jan; Spannagl, Michael

2005-04-18

BACKGROUND: Community-based cohort studies are not available that evaluated the predictive power of both clinical and genetic risk factors for venous thromboembolism (VTE). There is, however, clinical need to forecast the likelihood of future occurrence of VTE, at least qualitatively, to support decisions about intensity of diagnostic or preventive measures. MATERIALS AND METHODS: A 10-year observation period of the Bavarian Thromboembolic Risk (BATER) study, a cohort study of 4337 women (18-55 years), was used to develop a predictive model of VTE based on clinical and genetic variables at baseline (1993). The objective was to prepare a probabilistic scheme that discriminates women with virtually no VTE risk from those at higher levels of absolute VTE risk in the foreseeable future. A multivariate analysis determined which variables at baseline were the best predictors of a future VTE event, provided a ranking according to the predictive power, and permitted to design a simple graphic scheme to assess the individual VTE risk using five predictor variables. RESULTS: Thirty-four new confirmed VTEs occurred during the observation period of over 32,000 women-years (WYs). A model was developed mainly based on clinical information (personal history of previous VTE and family history of VTE, age, BMI) and one composite genetic risk markers (combining Factor V Leiden and Prothrombin G20210A Mutation). Four levels of increasing VTE risk were arbitrarily defined to map the prevalence in the study population: No/low risk of VTE (61.3%), moderate risk (21.1%), high risk (6.0%), very high risk of future VTE (0.9%). In 10.6% of the population the risk assessment was not possible due to lacking VTE cases. The average incidence rates for VTE in these four levels were: 4.1, 12.3, 47.2, and 170.5 per 104 WYs for no, moderate, high, and very high risk, respectively. CONCLUSION: Our prognostic tool - containing clinical information (and if available also genetic data) - seems to be worthwhile testing in medical practice in order to confirm or refute the positive findings of this study. Our cohort study will be continued to include more VTE cases and to increase predictive value of the model.

Transformational Autonomy and Personal Transportation: Synergies and Differences Between Cars and Planes

NASA Technical Reports Server (NTRS)

Goodrich, Kenneth H.; Nickolaou, Jim; Moore, Mark D.

2016-01-01

Highly automated cars have undergone tremendous investment and progress over the past ten years with speculation about fully-driverless cars within the foreseeable, or even near future, becoming common. If a driverless future is realized, what might be the impact on personal aviation? Would self-piloting airplanes be a relatively simple spin-off, possibly making travel by personal aircraft also commonplace? What if the technology for completely removing human drivers turns out to be further in the future rather than sooner; would such a delay suggest that transformational personal aviation is also somewhere over the horizon or can transformation be achieved with less than full automation? This paper presents a preliminary exploration of these questions by comparing the operational, functional, and implementation requirements and constraints of cars and small aircraft for on-demand mobility. In general, we predict that the mission management and perception requirements of self-piloting aircraft differ significantly from self-driving cars and requires the development of aviation specific technologies. We also predict that the highly-reliable control and system automation technology developed for conditionally and highly automated cars can have a significant beneficial effect on personal aviation, even if full automation is not immediately feasible.

Chromatic dispersion concentrator applied to photovoltaic systems

NASA Astrophysics Data System (ADS)

Sassi, G.

1980-01-01

The aim of this paper is to show how it is possible to realize a chromatic dispersion concentrator which collects the different monochromatic components of the solar spectrum separately in subsequently concentric rings in the focal zone. This comes about without an increase in the energetic losses compared to any other type of concentrator. If different photovoltaic elements with energy gaps equal to the photon energy falling on the focal zone are put in the latter, energy losses due to incomplete utilization of the solar spectrum and to incomplete utilization of the energy of a single photon can be drastically reduced. How the losses due to the voltage factor and the fill-factor of the photovoltaic elements of the system can be reduced compared to the normal silicon cells is also demonstrated. The other contributions to losses in the conversion process have only been mentioned, foreseeing their possible variation.

Revisiting Impulsivity in Suicide

PubMed Central

Smith, April R.; Witte, Tracy K.; Teale, Nadia E.; King, Sarah L.; Bender, Ted W.; Joiner, Thomas E.

2008-01-01

Previous research and popular conceptualizations of suicide have posited that many suicides are the result of impulsive, “on a whim” decisions. However, recent research demonstrates that most suicides are not attempted impulsively, and in fact involve a plan. Legally, suicide has historically been considered to be a superseding intervening cause of death that exonerates other parties from liability, but currently there are two general exceptions to this view. Specifically, another party may be found responsible for a suicide if that party either caused the suicide or failed in its duty to prevent the suicide from occurring. Both of these exceptions assume that the resulting suicide was foreseeable. Given that recent research has indicated that most suicides are planned, and thereby foreseeable to a certain extent under many circumstances, this article discusses issues of foreseeability as they pertain to litigation involving third party liability for the suicide of university students, prison inmates, and mental health patients. The authors contend that the surest way for universities, prison staff, and mental health practitioners to avoid being held liable for a suicide is to appropriately assess for suicidal intent. PMID:19039790

ICARUS: An Innovative Large LAR Detector for Neutrino Physics

NASA Astrophysics Data System (ADS)

Vignoli, C.; Barni, D.; Disdier, J. M.; Rampoldi, D.; Icarus Collaboration

2006-04-01

ICARUS is an international project that foresees the installation of very large LAr detectors inside the Gran Sasso underground laboratory in order to be sensitive to rare phenomena of particle physics. The detection technique is based on the collection of electrons produced by particle interactions in LAr by a matrix of thousands of thin wires. At the moment the project foresees the installation of a 600,000-kg vessel (T600). The total amount of LAr can be expanded in a modular way to masses of the order of 106 kg. The T600 houses two identical 300,000-kg Ar sub-cryostats that are aluminum boxes about 20-m long, 4-m high and 4-m wide. Safety requirements for the underground installation have led to a unique design for the vessels to prevent LAr spillages even in the case of inner cryostat failure. Electrons must drift over meters requiring the development of special gas and liquid Ar purification units to provide an extremely high LAr purity (better then 0.1 ppb). The cooling system has been designed to assure a high thermal uniformity in the detector volume (less than 1-K differential). The cryogenic system associated with the final ICARUS configuration is based on three N2 refrigerators, three 30-m3 tanks and pump driven two-phase N2 forced-flow cooling of the various sub-systems. The T600 was successfully tested in Pavia in 2001 and it is now under installation in Gran Sasso for final operation. The future mass expansion strategy is under investigation.

Rheumatology in the community of Madrid: current availability of rheumatologists and future needs using a predictive model.

PubMed

Lázaro y De Mercado, Pablo; Blasco Bravo, Antonio Javier; Lázaro y De Mercado, Ignacio; Castañeda, Santos; López Robledillo, Juan Carlos

2013-01-01

To: 1) describe the distribution of the public sector rheumatologists; 2) identify variables on which the workload in Rheumatology depends; and 3) build a predictive model on the need of rheumatologists for the next 10 years, in the Community of Madrid (CM). The information was obtained through structured questionnaires sent to all services/units of Rheumatology of public hospitals in the CM. The population figures, current and forecasted, were obtained from the National Statistics Institute. A predictive model was built based on information about the current and foreseeable supply, current and foreseeable demand, and the assumptions and criteria used to match supply with demand. The underlying uncertainty in the model was assessed by sensitivity analysis. In the CM in 2011 there were 150 staff rheumatologists and 49 residents in 27 centers, which is equivalent to one rheumatologist for every 33,280 inhabitants in the general population, and one for every 4,996 inhabitants over 65 years. To keep the level of assistance of 2011 in 2021 in the general population, it would be necessary to train more residents or hire more rheumatologists in scenarios of demand higher than 15%. However, to keep the level of assistance in the population over 65 years of age it would be necessary to train more residents or hire more specialists even without increased demand. The model developed may be very useful for planning, with the CM policy makers, the needs of human resources in Rheumatology in the coming years. Copyright © 2012 Elsevier España, S.L. All rights reserved.

Inventory Data Package for Hanford Assessments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kincaid, Charles T.; Eslinger, Paul W.; Aaberg, Rosanne L.

2006-06-01

This document presents the basis for a compilation of inventory for radioactive contaminants of interest by year for all potentially impactive waste sites on the Hanford Site for which inventory data exist in records or could be reasonably estimated. This document also includes discussions of the historical, current, and reasonably foreseeable (1944 to 2070) future radioactive waste and waste sites; the inventories of radionuclides that may have a potential for environmental impacts; a description of the method(s) for estimating inventories where records are inadequate; a description of the screening method(s) used to select those sites and contaminants that might makemore » a substantial contribution to impacts; a listing of the remedial actions and their completion dates for waste sites; and tables showing the best estimate inventories available for Hanford assessments.« less

Keeping Pace With Water and Wastewater Rates

DOE PAGES

Stratton, Hannah; Fuchs, Heidi; Chen, Yuting; ...

2017-10-01

We present that water and wastewater treatment and delivery are the most capital-intensive of all utility services. The literature indicates that historically underpriced water and wastewater rates have exhibited steadily high growth in the past 15 years, while the consumer price index (CPI) of water and sewage maintenance has outpaced the general CPI by an increasingly wide margin. This article employs a chained analysis method to examine water and wastewater rates for a group of utilities across US Census regions between 2000 and 2014. Results demonstrate that water and wastewater prices for this sample group have consistently increased and havemore » surpassed CPI growth since 2006. Finally, current and upcoming challenges facing water and wastewater utilities suggest that rate increases are likely to continue in the foreseeable future.« less

Fabrication of a wettability-gradient surface on copper by screen-printing techniques

NASA Astrophysics Data System (ADS)

Huang, Ding-Jun; Leu, Tzong-Shyng

2015-08-01

In this study, a screen-printing technique is utilized to fabricate a wettability-gradient surface on a copper substrate. The pattern definitions on the copper surface were freely fabricated to define the regions with different wettabilities, for which the printing definition technique was developed as an alternative to the existing costly photolithography techniques. This fabrication process using screen printing in tandem with chemical modification methods can easily realize an excellent wettability-gradient surface with superhydrophobicity and superhydrophilicity. Surface analyses were performed to characterize conditions in some fabrication steps. A water droplet movement sequence is provided to clearly demonstrate the droplet-driving effectiveness of the fabricated gradient surface. The droplet-driving efficiency offers a promising solution for condensation heat transfer applications in the foreseeable future.

[The implementation gap in asthma prevention and control?].

PubMed

Demoly, Pascal; Just, Jocelyne; Annesi-Maesano, Isabella; Bousquet, Jean; Michel, François-Bernard

2014-01-01

Asthma and allergic diseases generally start early in life and persist throughout life but, for reasons we do not yet understand, they sometimes appear later Prevention, early diagnosis and treatment of these major chronic respiratory diseases is a recognized priority for EU public health policy and for the United Nations. As factors favoring allergy (rapid urbanization, pollution, climate change and infections) are not expected to change in the foreseeable future, it is crucial to develop, strengthen and optimize prevention and treatment. We have developed tools to control asthma but are still unable to prevent children from developing asthma and allergic diseases. This article examines what works and what does not, and analyzes the "missing links" between the creation and effective implementation of a prevention program, otherwise known as the implementation gap.

The path to next generation biofuels: successes and challenges in the era of synthetic biology

PubMed Central

2010-01-01

Volatility of oil prices along with major concerns about climate change, oil supply security and depleting reserves have sparked renewed interest in the production of fuels from renewable resources. Recent advances in synthetic biology provide new tools for metabolic engineers to direct their strategies and construct optimal biocatalysts for the sustainable production of biofuels. Metabolic engineering and synthetic biology efforts entailing the engineering of native and de novo pathways for conversion of biomass constituents to short-chain alcohols and advanced biofuels are herewith reviewed. In the foreseeable future, formal integration of functional genomics and systems biology with synthetic biology and metabolic engineering will undoubtedly support the discovery, characterization, and engineering of new metabolic routes and more efficient microbial systems for the production of biofuels. PMID:20089184

Water quality in the Yukon River Basin, Alaska, water years 2006-2008

USGS Publications Warehouse

Schuster, Paul F.; Maracle, Karonhiakta'tie Bryan; Herman-Mercer, Nicole

2010-01-01

The Yukon River Inter-Tribal Watershed Council and the U.S. Geological Survey developed a water-quality monitoring program to address a shared interest in the water quality of the Yukon River and its relation to climate. This report contains water-quality data from samples collected in the Yukon River Basin during water years 2006 through 2008. A broad range of chemical analyses from 44 stations throughout the YRB are presented. On August 8, 2009 the USGS signed a Memorandum of Understanding with the Yukon River Inter-Tribal Watershed Council representing the culmination of 5 years of dedicated efforts to forge a working collaboration and partnership with expectations of continuing into the foreseeable future. The Memorandum of Understanding may be viewed at http://www.usgs.gov/mou/docs/yritwc_mou.pdf.

Keeping Pace With Water and Wastewater Rates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stratton, Hannah; Fuchs, Heidi; Chen, Yuting

We present that water and wastewater treatment and delivery are the most capital-intensive of all utility services. The literature indicates that historically underpriced water and wastewater rates have exhibited steadily high growth in the past 15 years, while the consumer price index (CPI) of water and sewage maintenance has outpaced the general CPI by an increasingly wide margin. This article employs a chained analysis method to examine water and wastewater rates for a group of utilities across US Census regions between 2000 and 2014. Results demonstrate that water and wastewater prices for this sample group have consistently increased and havemore » surpassed CPI growth since 2006. Finally, current and upcoming challenges facing water and wastewater utilities suggest that rate increases are likely to continue in the foreseeable future.« less

Commercialisation of Biomarker Tests for Mental Illnesses: Advances and Obstacles.

PubMed

Chan, Man K; Cooper, Jason D; Bahn, Sabine

2015-12-01

Substantial strides have been made in the field of biomarker research for mental illnesses over the past few decades. However, no US FDA-cleared blood-based biomarker tests have been translated into routine clinical practice. Here, we review the challenges associated with commercialisation of research findings and discuss how these challenges can impede scientific impact and progress. Overall evidence indicates that a lack of research funding and poor reproducibility of findings were the most important obstacles to commercialization of biomarker tests. Fraud, pre-analytical and analytical limitations, and inappropriate statistical analysis are major contributors to poor reproducibility. Increasingly, these issues are acknowledged and actions are being taken to improve data validity, raising the hope that robust biomarker tests will become available in the foreseeable future. Copyright © 2015 Elsevier Ltd. All rights reserved.

Thinking and doing, a long way to the top in commercialisation

NASA Astrophysics Data System (ADS)

Boswell, Rod

2013-09-01

A university's primary role is to educate and produce research results, mostly funded by the common weal. A business's primary role is to survive. Generally business wants ideas that help with their immediate problems into a 3 month foreseeable future. Universities are used to timescales at least an order of magnitude longer. The speaker's experience as lead guitar in a rock and roll band, building cars, running an offset printing firm, the helicon source and interacting with a Large American Manufacturer will be presented. His university research and development of a plasma source focussed ion beam, the creation of a start-up ``Oregon Physics,'' the subsequent industrial development and commercialisation, the distasteful legal wrangles about IP and the eventual emergence of OP into the sunshine of a successful operation will be described.

In defense of genuine ignorance: supporting vitality and relevance in graduate curricula.

PubMed

Goren, S; Peter, L; Fischer, S

1992-01-01

Genuine ignorance, defined by John Dewey as curiosity and openmindedness in opposition to repetition of catch phrases and familiar propositions, is nurtured in graduate nursing curricula in which the educational process is congruent with course content. Preparation for advanced practice in the mental health environment of the foreseeable future required abandonment of the familiar medical model in favor of conceptual models consistent with current thinking in psychiatric nursing and exposure to current problems (homelessness, family violence, AIDS) and current problem solving strategies (brief treatment, family preservation). Involvement in practice-based research and operationalizing new perspectives on familiar clinical problems, are suggested as strategies for developing the advanced practitioner. Two of the authors, former graduate students, describe the impact of changed perspectives and research activity on their own practice.

The place of human psychophysics in modern neuroscience.

PubMed

Read, J C A

2015-06-18

Human psychophysics is the quantitative measurement of our own perceptions. In essence, it is simply a more sophisticated version of what humans have done since time immemorial: noticed and reflected upon what we can see, hear, and feel. In the 21st century, when hugely powerful techniques are available that enable us to probe the innermost structure and function of nervous systems, is human psychophysics still relevant? I argue that it is, and that in combination with other techniques, it will continue to be a key part of neuroscience for the foreseeable future. I discuss these points in detail using the example of binocular stereopsis, where human psychophysics in combination with physiology and computational vision, has made a substantial contribution. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.

Nonlethal weapons as force options for the Army

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexander, J.B.

This paper suggests that future challenges to US national security will be very different from those previously experienced. In a number of foreseeable circumstances, conventional military force will be inappropriate. The National Command Authority, and other appropriate levels of command, need expanded options available to meet threats for which the application of massive lethal force is counterproductive or inadvisable. It is proposed that nonlethal concepts be developed that provide additional options for military leaders and politicians. Included in this initiative should be exploration of policy, strategy, doctrine, and training issues as well as the development of selected technologies and weapons.more » In addition, civilian law enforcement agencies have similar requirements for less-than-lethal systems. This may be an excellent example for a joint technology development venture.« less

Needs and Requirements for Future Research Reactors (ORNL Perspectives)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ilas, Germina; Bryan, Chris; Gehin, Jess C.

2016-02-10

The High Flux Isotope Reactor (HFIR) is a vital national and international resource for neutron science research, production of radioisotopes, and materials irradiation. While HFIR is expected to continue operation for the foreseeable future, interest is growing in understanding future research reactors features, needs, and requirements. To clarify, discuss, and compile these needs from the perspective of Oak Ridge National Laboratory (ORNL) research and development (R&D) missions, a workshop, titled “Needs and Requirements for Future Research Reactors”, was held at ORNL on May 12, 2015. The workshop engaged ORNL staff that is directly involved in research using HFIR to collectmore » valuable input on the reactor’s current and future missions. The workshop provided an interactive forum for a fruitful exchange of opinions, and included a mix of short presentations and open discussions. ORNL staff members made 15 technical presentations based on their experience and areas of expertise, and discussed those capabilities of the HFIR and future research reactors that are essential for their current and future R&D needs. The workshop was attended by approximately 60 participants from three ORNL directorates. The agenda is included in Appendix A. This document summarizes the feedback provided by workshop contributors and participants. It also includes information and insights addressing key points that originated from the dialogue started at the workshop. A general overview is provided on the design features and capabilities of high performance research reactors currently in use or under construction worldwide. Recent and ongoing design efforts in the US and internationally are briefly summarized, followed by conclusions and recommendations.« less

Working group on future trends

USGS Publications Warehouse

,; O'Shea, Thomas J.; Reeves, Randall R.; Long, Alison Kirk

1999-01-01

This working group did not divide into subgroups, and its report consists of a unified document in a format somewhat different than those of the other working groups. The group considered four major topics: (1) projected "new" contaminants of future concern; (2) future trends with contaminants currently known to be issues for marine mammals; (3) future needs to improve and insure consistency of sample collection and analyses; and (4) future management needs.The problems of persistent organic pollutants will remain well into the foreseeable future. A general decline in levels of persistent organic pollutants in the marine environment is not anticipated. there is every likelihood that the environmental trends of halogenated organic compounds, such as polybromated diphenyl ethers and chlorinated paraffins, will parallel production trends, as demonstrated with well known chemical contaminants such as PCBs (polychlorinated biphenyls) and DDT (dichlorodiphenyltrichloroethane). While the environmental levels of some compounds may be slowly declining, many are still within the ranges where subtle toxic effects are to be anticipated. Trends in contaminants must be placed in a regional context, and rates and directions of change are often region-specific. For example, in the Southern Hemisphere the concentrations of PCBs appear to be increasing. The rates of change of many contaminants in the Southern hemisphere are poorly known, and this region may be at future risk.Much of the research on contaminants and marine mammals has focused on the problem of persistent organochloride chemicals such as PCBs and DDT, which are a continuing and global problem. Potential problems caused by other persistent, toxic, and bioaccumulative substances (PTBSs) cannot currently be addressed due to the lack of basic information on their production, use, exposure, and effects (Environmental Protection Agency 1998). It is currently estimated that there are roughly 2400 lipophilic and persistent chemicals, of which 390 are PTBSs. In order to prevent long-term pollution from these largely unknown chemicals, chemical industries should disclose basic information on such compounds, and this information should be made widely available. This will require enhanced international cooperation, preferably within the existing framework of chemical contaminant programs, such as the Existing Chemicals Program of the Organization for Economic Cooperation and Development (1991) and the Program on persistent Organic Pollutants of the United National Environmental Programme (1998).Monitoring studies are essential to the description and understanding of pollutants. It is necessary to exploit existing analytical techniques to identify as many anthropogenic compounds as possible in marine mammal tissues in order to expand the identification of existing and new chemicals that accumulate in, and pose threats to, these species.

Is groundwater discharge the dominant source of nutrients to Alabama estuaries and will it keep impacting these waters for the foreseeable future?

NASA Astrophysics Data System (ADS)

Mortazavi, B.; Domangue, R.; Kleinhuizen, A.; Tatariw, C.

2017-12-01

Land use change and population growth are dominant factors impacting coastal waters. Populations in Alabama coastal counties have increased by several folds since the 1950s and a large fraction of the farmed land are now being used for growing sod requiring large amounts of fertilizers. Concurrent with these changes, marshes bordering Mobile Bay have been disappearing such that they now only cover 50% of their areal extent compared to the 1780s. These changes in land use and coastal geomorphology, as well as the population growth ultimately result in larger delivery of nutrients either through runoff or groundwater discharge to the coastal waters. The Mobile Bay estuary in Alabama is bordered with several subestuaries and a coastal lagoon. Our investigations suggest that the large inputs of nutrients through river discharge in Weeks Bay (140 g N m-2 yr-1) and groundwater discharge in Little Lagoon (300 g N m-2 yr-1) by far dominate inputs of N to the water column and exceed N input, for example, from benthic regeneration, by an order of magnitude. Furthermore, the capacity for N removal through denitrification in these systems is low and instead nitrogen is retained through dissimilatory nitrate reduction to ammonium at a rate that exceed denitrification by an order of magnitude. Our measurements also suggest that once marshes are transformed to subtidal unvegetated sediments rates of nitrogen removal by denitrification decline four folds. Excessive inputs of nitrogen and the high efficiency with which nitrogen is retained in these systems is impacting the foodweb and harmful algal blooms and fish kills are reoccurring events. While changes in agricultural practices and reconstruction of marshes can potentially reduce the delivery of N or enhance N removal by denitrification, nutrient inputs through groundwater discharge are going to impact these estuaries for the foreseeable future. Our capacity to construct nutrient budgets and to predict the trajectory of ecosystem changes will therefore depend greatly on accurate knowledge of groundwater discharge to these systems. Quantifying the magnitudes of groundwater derived nutrients and the fate of these nutrients in nearshore systems requires concerted efforts amongst hydrologists, biogeochemists, and ecologists.

Factors influencing the retention of registered nurses in the Gauteng Province of South Africa.

PubMed

Mokoka, Kgaogelo E; Ehlers, Valerie J; Oosthuizen, Martha J

2011-12-14

South Africa is a source country for many destination countries that recruit registered nurses who emigrate for personal and/or professional reasons. A large number of South African nurses belong to the baby boomer generation (born between 1943 and 1964) who will retire within the foreseeable future. Statistics from the South African Nursing Council show a decline of 42.0% in the number of nurses who completed their training in South Africa from 1996 to 2005. These aspects combine to predict a potential dire shortage of nurses in South Africa within the foreseeable future. Retention of registered nurses should be the focus of health-care planners to avoid crises in South Africa's health-care services. This study attempted to identify factors that would influence registered nurses' decisions to stay with their current employers in the Gauteng Province of South Africa. An exploratory descriptive quantitative design was adopted and questionnaires were sent to a sample of nurses, registered with the South African Nursing Council (SANC), with addresses in the Gauteng Province. A total of 108 nurses completed and returned questionnaires, of whom 77 (73.1%) had considered leaving their current employers. The most important factors that would influence more than 90.0% of these nurses' decisions to stay with their current employers related to finances, safety and security, equipment and/or supplies, management, staff and patients. In terms of Maslow's Hierarchy of Needs Theory, deficiency needs (physiological, safety and social needs) should be met by improved salaries revised on an annual basis, paying long-service and outstanding-service bonuses, and improving the safety and security, as well the available equipment and supplies, at institutions. Sufficient numbers of nurses should be employed and vacancies should be filled rapidly. However, not all changes required to enhance nurses' retention rates involve increased costs. Managers should lead by example and respect nurses, and encourage doctors as well as patients to do so, to meet nurses' self-esteem needs. Recognising and rewarding outstanding service would meet nurses' self-actualisation needs, as well as opportunities to further their education.

Automation, Autonomy & Megacities 2025: A Dark Preview

DOE Office of Scientific and Technical Information (OSTI.GOV)

Assante, Michael; Bochman, Andrew

This paper extrapolates from present trends to describe very plausible – and actually quite likely – future crises playing out in multiple global cities. While predicting the future is fraught with uncertainty, much of what occurs in the scenarios that follow is fully possible today and absent a significant course change, probable in the timeframe discussed. The authors want to caveat that we are not commenting on a specific organization or technology deployment. It is not hard to find tech evangelists touting that ubiquitous and highly interconnected digital technology will bring great advances in productivity and efficiency, as well asmore » new capabilities we cannot foresee. This paper attempts to reveal what is possible when these technologies are applied to critical infrastructure applications en masse without adequate security in densely populated cities that by their nature are less resilient than other environments. Megacities need and will deploy these new technologies to keep up with insatiable demand for energy, communications, transportation and other services, but it is important to recognize that they are also made more vulnerable by following this path .« less

Biological treatment strategies for disc degeneration: potentials and shortcomings

PubMed Central

Nerlich, Andreas G.; Boos, Norbert

2006-01-01

Recent advances in molecular biology, cell biology and material sciences have opened a new emerging field of techniques for the treatment of musculoskeletal disorders. These new treatment modalities aim for biological repair of the affected tissues by introducing cell-based tissue replacements, genetic modifications of resident cells or a combination thereof. So far, these techniques have been successfully applied to various tissues such as bone and cartilage. However, application of these treatment modalities to cure intervertebral disc degeneration is in its very early stages and mostly limited to experimental studies in vitro or in animal studies. We will discuss the potential and possible shortcomings of current approaches to biologically cure disc degeneration by gene therapy or tissue engineering. Despite the increasing number of studies examining the therapeutic potential of biological treatment strategies, a practicable solution to routinely cure disc degeneration might not be available in the near future. However, knowledge gained from these attempts might be applied in a foreseeable future to cure the low back pain that often accompanies disc degeneration and therefore be beneficial for the patient. PMID:16983559

Willingness to pay for hypothetical malaria vaccines in rural Burkina Faso.

PubMed

Sauerborn, Rainer; Gbangou, Adjima; Dong, Hengjin; Przyborski, Jude M; Lanzer, Michael

2005-01-01

This study aims to set priorities for anti-disease malaria vaccines by determining community preference in a hyperendemic area. A bidding game technique was used to elucidate willingness to pay in rural Burkina Faso and 2,326 adults were interviewed. It is shown that there are significant differences between community preference for an anti-disease vaccine aimed at reducing pathology in pregnant women, and for a vaccine directed against childhood malaria. While the target population was willing to pay CFAfr 2101 for a vaccine against maternal malaria, its members were prepared to pay only CFAfr 1433 for a vaccine against childhood malaria. Whilst it is increasingly likely that anti-disease malaria vaccines will become available in the foreseeable future, lessons from the past suggest that a lack of acceptance and support from the intended recipients may lead to less than optimal compliance, and hence efficacy. For the planning of vaccine development and application strategies, it is therefore highly important to take community views into account. Here it is argued that such information could help researchers and funding agencies to set priorities for future vaccine research.

Stockpile stewardship past, present, and future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Marvin L., E-mail: mladams@tamu.edu

2014-05-09

The U.S. National Academies released a report in 2012 on technical issues related to the Comprehensive Test Ban Treaty. One important question addressed therein is whether the U.S. could maintain a safe, secure, and reliable nuclear-weapons stockpile in the absence of nuclear-explosion testing. Here we discuss two main conclusions from the 2012 Academies report, which we paraphrase as follows: 1) Provided that sufficient resources and a national commitment to stockpile stewardship are in place, the U.S. has the technical capabilities to maintain a safe, secure, and reliable stockpile of nuclear weapons into the foreseeable future without nuclear-explosion testing. 2) Doingmore » this would require: a) a strong weapons science and engineering program that addresses gaps in understanding; b) an outstanding workforce that applies deep and broad weapons expertise to deliver solutions to stockpile problems; c) a vigorous, stable surveillance program that delivers the requisite data; d) production facilities that meet stewardship needs. We emphasize that these conclusions are independent of CTBT ratification-they apply provided only that the U.S. continues its nuclear-explosion moratorium.« less

The Energy Future.

PubMed

Newman, John; Bonino, Christopher A; Trainham, James A

2018-06-07

The foreseeable energy future will be driven by economics of known technologies and the desire to reduce CO 2 emissions to the atmosphere. Renewable energy options are compared with each other and with the use of fossil fuels with carbon capture and sequestration (CCS). Economic analysis is used to determine the best of several alternatives. One can disagree on the detailed costs, including externalities such as climate change and air and water pollution. But the differences in capital and operating costs between known technologies are so significant that one can draw clear conclusions. Results show that renewable energy cannot compete with fossil fuels on a cost basis alone because energy is intrinsic to the molecule, except for hydroelectricity. However, fossil fuels are implicated in climate change. Using renewable energy exclusively, including transportation and electricity needs, could reduce the standard of living in the United States by 43% to 62%, which would correspond to the level in about 1970. If capture and sequester of CO 2 are implemented, the cost of using fossil fuels will increase, but they beat renewable energy handily as an economic way to produce clean energy.

[Clinical neuropsychology in perspective: future challenges based on current developments].

PubMed

Verdejo-García, Antonio; Tirapu-Ustárroz, Javier

2012-02-01

New lines of translational, interdisciplinary research are emerging among different fields of the neurosciences, which often point at clinical neuropsychology as the hinge discipline capable of linking the basic findings with their clinical implications and thereby endow them with some meaning for phenomenological experience. To establish the great lines of progress made in the fields of neuroscience and neuropsychology in recent years, so as to be able to foresee the strategic lines and priorities of neuroscience in the near future. To achieve this aim, the first step will be to identify the changes of paradigm that have taken place in the areas of neuroscience and psychology in the last two decades. The next step will be to propose new topics and fields of application that these changes in paradigm offer and demand from neuroscience. The false dichotomies of genes versus environment, mind versus brain, and reason versus emotion are considered, as are the new applications of neuropsychology to the understanding of psychopathological disorders, from the neurodegenerative to neurodevelopment, from 'dirty' drugs to cognitive and affective enhancers.

Using geologic structures to constrain constitutive laws not accessible in the laboratory

USGS Publications Warehouse

Nevitt, Johanna; Warren, Jessica M.; Kumamoto, Kathryn M.; Pollard, David D.

2018-01-01

In this essay, we explore a central problem of structural geology today, and in the foreseeable future, which is the determination of constitutive laws governing rock deformation to produce geologic structures. Although laboratory experiments provide much needed data and insights about constitutive laws, these experiments cannot cover the range of conditions and compositions relevant to the formation of geologic structures. We advocate that structural geologists address this limitation by interpreting natural experiments, documented with field and microstructural data, using continuum mechanical models that enable the deduction of constitutive laws. To put this procedure into a historical context, we review the founding of structural geology by James Hutton in the late 18th century, and the seminal contributions to continuum mechanics from Newton to Cauchy that provide the tools to model geologic structures. The procedure is illustrated with two examples drawn from recent and on-going field investigations of crustal and mantle lithologies. We conclude by pointing to future research opportunities that will engage structural geologists in the pursuit of constitutive laws during the 21st century.

Phosphorene: Fabrication, properties, and applications

DOE PAGES

Kou, Liangzhi; Chen, Changfeng; Smith, Sean C.

2015-06-24

Phosphorene, the single- or few-layer form of black phosphorus, was recently rediscovered as a two-dimensional layered material holding great promise for applications in electronics and optoelectronics. Research into its fundamental properties and device applications has since seen exponential growth. In this Perspective, we review recent progress in phosphorene research, touching upon topics on fabrication, properties, and applications; we also discuss challenges and future research directions. We highlight the intrinsically anisotropic electronic, transport, optoelectronic, thermoelectric, and mechanical properties of phosphorene resulting from its puckered structure in contrast to those of graphene and transition-metal dichalcogenides. The facile fabrication and novel properties ofmore » phosphorene have inspired design and demonstration of new nanodevices; however, further progress hinges on resolutions to technical obstructions like surface degradation effects and nonscalable fabrication techniques. We also briefly describe the latest developments of more sophisticated design concepts and implementation schemes that address some of the challenges in phosphorene research. As a result, it is expected that this fascinating material will continue to offer tremendous opportunities for research and development for the foreseeable future.« less

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges.

PubMed

Alayed, Mrwan; Deen, M Jamal

2017-09-14

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system.

Understanding and Optimizing Asynchronous Low-Precision Stochastic Gradient Descent

PubMed Central

De Sa, Christopher; Feldman, Matthew; Ré, Christopher; Olukotun, Kunle

2018-01-01

Stochastic gradient descent (SGD) is one of the most popular numerical algorithms used in machine learning and other domains. Since this is likely to continue for the foreseeable future, it is important to study techniques that can make it run fast on parallel hardware. In this paper, we provide the first analysis of a technique called Buckwild! that uses both asynchronous execution and low-precision computation. We introduce the DMGC model, the first conceptualization of the parameter space that exists when implementing low-precision SGD, and show that it provides a way to both classify these algorithms and model their performance. We leverage this insight to propose and analyze techniques to improve the speed of low-precision SGD. First, we propose software optimizations that can increase throughput on existing CPUs by up to 11×. Second, we propose architectural changes, including a new cache technique we call an obstinate cache, that increase throughput beyond the limits of current-generation hardware. We also implement and analyze low-precision SGD on the FPGA, which is a promising alternative to the CPU for future SGD systems. PMID:29391770

Solar Photochemical Synthesis: From the Beginnings of Organic Photochemistry to the Solar Manufacturing of Commodity Chemicals.

PubMed

Oelgemöller, Michael

2016-09-14

Natural sunlight offers a cost-efficient and sustainable energy source for photochemical reactions. In contrast to the lengthy and small-scale "flask in the sun" procedures of the past, modern solar concentrator systems nowadays significantly shorten reaction times and enable technical-scale operations. After a brief historical introduction, this review presents the most important solar reactor types and their successful application in preparative solar syntheses. The examples demonstrate that solar manufacturing of fine chemicals is technically feasible and environmentally sustainable. After over 100 years, Ciamician's prophetic vision of "the photochemistry of the future" as a clean and green manufacturing methodology has yet to be realized. At the same time, his warning "for nature is not in a hurry but mankind is" is still valid today. It is hoped that this review will lead to a renewed interest in this truly enlightening technology, that it will stimulate photochemists and photochemical engineers to "go back to the roots onto the roofs" and that it will ultimately result in industrial applications in the foreseeable future.

High-order computational fluid dynamics tools for aircraft design

PubMed Central

Wang, Z. J.

2014-01-01

Most forecasts predict an annual airline traffic growth rate between 4.5 and 5% in the foreseeable future. To sustain that growth, the environmental impact of aircraft cannot be ignored. Future aircraft must have much better fuel economy, dramatically less greenhouse gas emissions and noise, in addition to better performance. Many technical breakthroughs must take place to achieve the aggressive environmental goals set up by governments in North America and Europe. One of these breakthroughs will be physics-based, highly accurate and efficient computational fluid dynamics and aeroacoustics tools capable of predicting complex flows over the entire flight envelope and through an aircraft engine, and computing aircraft noise. Some of these flows are dominated by unsteady vortices of disparate scales, often highly turbulent, and they call for higher-order methods. As these tools will be integral components of a multi-disciplinary optimization environment, they must be efficient to impact design. Ultimately, the accuracy, efficiency, robustness, scalability and geometric flexibility will determine which methods will be adopted in the design process. This article explores these aspects and identifies pacing items. PMID:25024419

Surface acoustic wave devices for sensor applications

NASA Astrophysics Data System (ADS)

Bo, Liu; Xiao, Chen; Hualin, Cai; Mohammad, Mohammad Ali; Xiangguang, Tian; Luqi, Tao; Yi, Yang; Tianling, Ren

2016-02-01

Surface acoustic wave (SAW) devices have been widely used in different fields and will continue to be of great importance in the foreseeable future. These devices are compact, cost efficient, easy to fabricate, and have a high performance, among other advantages. SAW devices can work as filters, signal processing units, sensors and actuators. They can even work without batteries and operate under harsh environments. In this review, the operating principles of SAW sensors, including temperature sensors, pressure sensors, humidity sensors and biosensors, will be discussed. Several examples and related issues will be presented. Technological trends and future developments will also be discussed. Project supported by the National Natural Science Foundation of China (Nos. 60936002, 61025021, 61434001, 61574083), the State Key Development Program for Basic Research of China (No. 2015CB352100), the National Key Project of Science and Technology (No. 2011ZX02403-002) and the Special Fund for Agroscientific Research in the Public Interest of China (No. 201303107). M.A.M is additionally supported by the Postdoctoral Fellowship (PDF) program of the Natural Sciences and Engineering Research Council (NSERC) of Canada and the China Postdoctoral Science Foundation (CPSF).

Lifelong education for older adults in Malta: Current trends and future visions

NASA Astrophysics Data System (ADS)

Formosa, Marvin

2012-04-01

With European demographic developments causing a decline of the available workforce in the foreseeable future and the unsustainability of dominant pay-as-you-go pension systems (where contributions from the current workforce sustain pensioners), governments need to come up with strategies to deal with this upcoming challenge and to adjust their policies. Based on a study carried out between September 2009 and May 2010, this article evaluates the policies guiding late-life education in Malta, as well as the local plethora of learning opportunities for older adult education, and participation rates. The Maltese government is committed to supporting the inclusion of older persons (aged 60+) in lifelong education policies and programmes, to the extent that local studies have uncovered a recent rise in the overall participation of older adults in formal, non-formal and informal areas of learning. While the present and future prospects for late-life education in Malta seem promising, a critical scrutiny of present ideologies and trends finds the field to be no more than seductive rhetoric. Though the coordination of late-life education in Malta does result in various social benefits to older learners and Maltese society in general, it also occurs within five intersecting lines of inequality - namely an economic rationale, elitism, gender bias, the urban-rural divide and third ageism. This article ends by proposing policy recommendations for the future of late-life education.

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

PubMed Central

Unemo, Magnus

2014-01-01

SUMMARY Neisseria gonorrhoeae is evolving into a superbug with resistance to previously and currently recommended antimicrobials for treatment of gonorrhea, which is a major public health concern globally. Given the global nature of gonorrhea, the high rate of usage of antimicrobials, suboptimal control and monitoring of antimicrobial resistance (AMR) and treatment failures, slow update of treatment guidelines in most geographical settings, and the extraordinary capacity of the gonococci to develop and retain AMR, it is likely that the global problem of gonococcal AMR will worsen in the foreseeable future and that the severe complications of gonorrhea will emerge as a silent epidemic. By understanding the evolution, emergence, and spread of AMR in N. gonorrhoeae, including its molecular and phenotypic mechanisms, resistance to antimicrobials used clinically can be anticipated, future methods for genetic testing for AMR might permit region-specific and tailor-made antimicrobial therapy, and the design of novel antimicrobials to circumvent the resistance problems can be undertaken more rationally. This review focuses on the history and evolution of gonorrhea treatment regimens and emerging resistance to them, on genetic and phenotypic determinants of gonococcal resistance to previously and currently recommended antimicrobials, including biological costs or benefits; and on crucial actions and future advances necessary to detect and treat resistant gonococcal strains and, ultimately, retain gonorrhea as a treatable infection. PMID:24982323

Role of modern chemistry in sustainable arable crop protection.

PubMed

Smith, Keith; Evans, David A; El-Hiti, Gamal A

2008-02-12

Organic chemistry has been, and for the foreseeable future will remain, vitally important for crop protection. Control of fungal pathogens, insect pests and weeds is crucial to enhanced food provision. As world population continues to grow, it is timely to assess the current situation, anticipate future challenges and consider how new chemistry may help meet those challenges. In future, agriculture will increasingly be expected to provide not only food and feed, but also crops for conversion into renewable fuels and chemical feedstocks. This will further increase the demand for higher crop yields per unit area, requiring chemicals used in crop production to be even more sophisticated. In order to contribute to programmes of integrated crop management, there is a requirement for chemicals to display high specificity, demonstrate benign environmental and toxicological profiles, and be biodegradable. It will also be necessary to improve production of those chemicals, because waste generated by the production process mitigates the overall benefit. Three aspects are considered in this review: advances in the discovery process for new molecules for sustainable crop protection, including tests for environmental and toxicological properties as well as biological activity; advances in synthetic chemistry that may offer efficient and environmentally benign manufacturing processes for modern crop protection chemicals; and issues related to energy use and production through agriculture.

Future time perspective: A systematic review and meta-analysis.

PubMed

Kooij, Dorien T A M; Kanfer, Ruth; Betts, Matt; Rudolph, Cort W

2018-04-23

The ability to foresee, anticipate, and plan for future desired outcomes is crucial for well-being, motivation, and behavior. However, theories in organizational psychology do not incorporate time-related constructs such as Future Time Perspective (FTP), and research on FTP remains disjointed and scattered, with different domains focusing on different aspects of the construct, using different measures, and assessing different antecedents and consequences. In this review and meta-analysis, we aim to clarify the FTP construct, advance its theoretical development, and demonstrate its importance by (a) integrating theory and empirical findings across different domains of research to identify major outcomes and antecedents of FTP, and (b) empirically examining whether and how these variables are moderated by FTP measures and dimensions. Results of a meta-analysis of k = 212 studies reveal significant relationships between FTP and major classes of consequences (i.e., those related to achievement, well-being, health behavior, risk behavior, and retirement planning), and between antecedents and FTP, as well as moderating effects of different FTP measures and dimensions. Highlighting the importance of FTP for organizational psychology theories, our findings demonstrate that FTP predicts these outcomes over and above the big five personality traits and mediates the associations between these personality traits and outcomes. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Novelty and Foreseeing Research Trends: The Case of Astrophysics and Astronomy

NASA Astrophysics Data System (ADS)

Varga, Attila

2018-05-01

Metrics based on reference lists of research articles or on keywords have been used to predict citation impact. The concept behind such metrics is that original ideas stem from the reconfiguration of the structure of past knowledge, and therefore atypical combinations in the reference lists, keywords, or classification codes indicate future high-impact research. The current paper serves as an introduction to this line of research for astronomers and also addresses some of the methodological questions in this field of innovation studies. It is still not clear if the choice of particular indexes, such as references to journals, articles, or specific bibliometric classification codes affects the relationship between atypical combinations and citation impact. To understand more aspects of the innovation process, a new metric has been devised to measure to what extent researchers are able to anticipate the changing combinatorial trends of the future. Results show that the variant of the latter anticipation scores that is based on paper combinations is a good predictor of the future citation impact of scholarly works. The study also shows that the effects of tested indexes vary with the aggregation levels that were used to construct them. A detailed analysis of combinatorial novelty in the field reveals that certain sub-fields of astronomy and astrophysics have different roles in the reconfiguration of past knowledge.

The validity of contracts to dispose of frozen embryos

PubMed Central

Pennings, G

2002-01-01

The widespread abandonment of frozen embryos by the gamete providers or intentional parents urgently demands a solution. Most centres react by requiring patients to enter a prior agreement governing the future disposition of their embryos in all foreseeable circumstances. These dispositional directives are inappropriate and self defeating in the event of contingencies in which the patients remain competent to execute an updated directive. Internal and external changes may invalidate the prior directive by altering the situation as represented by the couple at the initiation of treatment to such an extent that it no longer corresponds with the actual situation at the time of the execution of the disposition. The prior agreement should only be considered binding if the agreement among the partners on a specific option was a material condition for one of the partners to start treatment. PMID:12356956

Climatology of Urban-regional Systems

NASA Technical Reports Server (NTRS)

Pease, R. W.

1971-01-01

Urbanized areas have come to be significant if not dominant components of many regional land surfaces. They represent perhaps the most dramatic recent change man has made in his environment - a change that may well burgeon in the foreseeable future as greater percentages of world populations crowd into metropolitan areas. The climate of urban-regional systems is involved because temperature, air, and pollutants added to the air are significant aspects of this change. During the past two years, substantial progress has been made in the application of remote sensing techniques to the study of urban climatology by programs jointly sponsored by NASA and the United States Geological Survey. The initial effort has endeavored with considerable success to map terrestrial radiation emission or the general thermal state of the land surface with the aid of imaging radiometers (mechanical-optical scanners).

Climate Prediction Sees Future Despite Chaos: Researchers Outside NASA use NCCS Resources for Studies

NASA Technical Reports Server (NTRS)

2002-01-01

The air on this mostly sunny January day is crisp and the wind is blustery. The morning's National Weather Service 6-hour forecast had accurately predicted these conditions for the Baltimore-Washington area and the 2-3 day extended outlook was almost perfect. The previous week, the National Center for Environmental Prediction's (NCEP) 6-10 day temperature and precipitation outlook for the general trends for the' region was correct as well. However, no forecast could have predicted specific details about this day. It is 28.5 F in the sunshine bright enough for dark sunglasses, and windy enough to blow off a hat. Such details are impossible to foresee with any accuracy and are outside the scope of routine weather prediction. Equally difficult is accurately forecasting weather beyond about 2 weeks.

Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

PubMed Central

Toyoshima, Koh-ei; Asakawa, Kyosuke; Ishibashi, Naoko; Toki, Hiroshi; Ogawa, Miho; Hasegawa, Tomoko; Irié, Tarou; Tachikawa, Tetsuhiko; Sato, Akio; Takeda, Akira; Tsuji, Takashi

2012-01-01

Organ replacement regenerative therapy is purported to enable the replacement of organs damaged by disease, injury or aging in the foreseeable future. Here we demonstrate fully functional hair organ regeneration via the intracutaneous transplantation of a bioengineered pelage and vibrissa follicle germ. The pelage and vibrissae are reconstituted with embryonic skin-derived cells and adult vibrissa stem cell region-derived cells, respectively. The bioengineered hair follicle develops the correct structures and forms proper connections with surrounding host tissues such as the epidermis, arrector pili muscle and nerve fibres. The bioengineered follicles also show restored hair cycles and piloerection through the rearrangement of follicular stem cells and their niches. This study thus reveals the potential applications of adult tissue-derived follicular stem cells as a bioengineered organ replacement therapy. PMID:22510689

Micro-UAV tracking framework for EO exploitation

NASA Astrophysics Data System (ADS)

Browning, David; Wilhelm, Joe; Van Hook, Richard; Gallagher, John

2012-06-01

Historically, the Air Force's research into aerial platforms for sensing systems has focused on low-, mid-, and highaltitude platforms. Though these systems are likely to comprise the majority of the Air Force's assets for the foreseeable future, they have limitations. Specifically, these platforms, their sensor packages, and their data exploitation software are unsuited for close-quarter surveillance, such as in alleys and inside of buildings. Micro-UAVs have been gaining in popularity, especially non-fixed-wing platforms such as quad-rotors. These platforms are much more appropriate for confined spaces. However, the types of video exploitation techniques that can effectively be used are different from the typical nadir-looking aerial platform. This paper discusses the creation of a framework for testing existing and new video exploitation algorithms, as well as describes a sample micro-UAV-based tracker.

"What Are You Viewing?" Exploring the Pervasive Social TV Experience

NASA Astrophysics Data System (ADS)

Schatz, Raimund; Baillie, Lynne; Fröhlich, Peter; Egger, Sebastian; Grechenig, Thomas

The vision of pervasive TV foresees users engaging with interactive video services across a variety of contexts and user interfaces. Following this idea, this chapter extends traditional Social TV toward the notion of pervasive Social TV (PSTV) by including mobile viewing scenarios. We discuss social interaction enablers that integrate TV content consumption and communication in the context of two case studies that evaluate Social TV on mobile smartphones as well as the traditional set-top-box-based setup. We report on the impact of social features such as text-chat, audio-chat, and synchronized channel-choice on the end-user's media experience. By analyzing the commonalities and the differences between mobile and living-room Social TV that we found, we provide guidance on the design of pervasive Social TV systems as well as on future research issues.

Improving the current system for supplying organs for transplantation.

PubMed

Horton, R L; Horton, P J

1993-01-01

The United States currently relies on a voluntary, altruistic system for supplying organs for transplantation. It is now generally recognized that this system, as currently operated, produces a seriously inadequate supply of organs. A number of scholars have argued that some type of (generally unspecified) market system is necessary. Two articles appearing in the Journal of Health Politics, Policy and Law have proposed relatively specific market systems for increasing the supply of organs. In this paper we argue that market systems are at best premature. In particular, there is little to suggest that any type of market system for organs will be permitted in the United States in the foreseeable future. We present data that strongly suggest that the current voluntary, altruistic system has not been developed to its full potential and offer a number of specific suggestions for improving the system.

Recovery Act: Waste Energy Project at AK Steel Corporation Middletown

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joyce, Jeffrey

2012-06-30

In 2008, Air Products and Chemicals, Inc. (“Air Products”) began development of a project to beneficially utilize waste blast furnace “topgas” generated in the course of the iron-making process at AK Steel Corporation’s Middletown, Ohio works. In early 2010, Air Products was awarded DOE Assistance Agreement DE-EE002736 to further develop and build the combined-cycle power generation facility. In June 2012, Air Products and AK Steel Corporation terminated work when it was determined that the project would not be economically viable at that time nor in the foreseeable future. The project would have achieved the FOA-0000044 Statement of Project Objectives bymore » demonstrating, at a commercial scale, the technology to capture, treat, and convert blast furnace topgas into electric power and thermal energy.« less

Chemical cross-linking and native mass spectrometry: A fruitful combination for structural biology

PubMed Central

Sinz, Andrea; Arlt, Christian; Chorev, Dror; Sharon, Michal

2015-01-01

Mass spectrometry (MS) is becoming increasingly popular in the field of structural biology for analyzing protein three-dimensional-structures and for mapping protein–protein interactions. In this review, the specific contributions of chemical crosslinking and native MS are outlined to reveal the structural features of proteins and protein assemblies. Both strategies are illustrated based on the examples of the tetrameric tumor suppressor protein p53 and multisubunit vinculin-Arp2/3 hybrid complexes. We describe the distinct advantages and limitations of each technique and highlight synergistic effects when both techniques are combined. Integrating both methods is especially useful for characterizing large protein assemblies and for capturing transient interactions. We also point out the future directions we foresee for a combination of in vivo crosslinking and native MS for structural investigation of intact protein assemblies. PMID:25970732

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laitner, S.

In the current economic climate and for the foreseeable future, resource policy (especially with respect to energy consumption) has the potential to make a profound impact upon the economic life of our communities. Energy and economic policies should be viewed as catalysts that can help a community - and ultimately a state, or even a nation - achieve larger societal goals such as enhanced employment opportunities. To achieve this potential, we must divorce ourselves from unproductive past concepts and understand the inherent constraints associated with resource utilization to better work them to the advantage of the community. The key elementmore » here is to ensure that community economic goals shape the policymaking process. Without such considerations neither communities nor their respective nations will be able to offset fully the growing economic burden imposed by restrictions arising from a ''business-as-usual'' approach to resource utilization.« less

Huddleston v. Infertility Center of America.

PubMed

1997-08-20

The Pennsylvania Superior Court held that a surrogate mother could sue a surrogacy clinic for the sperm-donor father's murder of the child she bore. One month after delivery, the child died from severe brain and head injuries caused by his biological father. The court held that a "special relationhsip" exists between a surrogacy business, its client-participants, and the child which is born. In this "special relationship" the surrogacy business has an affirmative duty to protect the surrogate mother and child from foreseeable harm. The court held that child abuse was a legally foreseeable harm in the surrogacy business, but whether child abuse leading to death is forseeable under a particular set of acts is a jury question.

Probing Models of Dark Matter and the Early Universe

NASA Astrophysics Data System (ADS)

Orlofsky, Nicholas David

This thesis discusses models for dark matter (DM) and their behavior in the early universe. An important question is how phenomenological probes can directly search for signals of DM today. Another topic of investigation is how the DM and other processes in the early universe must evolve. Then, astrophysical bounds on early universe dynamics can constrain DM. We will consider these questions in the context of three classes of DM models--weakly interacting massive particles (WIMPs), axions, and primordial black holes (PBHs). Starting with WIMPs, we consider models where the DM is charged under the electroweak gauge group of the Standard Model. Such WIMPs, if generated by a thermal cosmological history, are constrained by direct detection experiments. To avoid present or near-future bounds, the WIMP model or cosmological history must be altered in some way. This may be accomplished by the inclusion of new states that coannihilate with the WIMP or a period of non-thermal evolution in the early universe. Future experiments are likely to probe some of these altered scenarios, and a non-observation would require a high degree of tuning in some of the model parameters in these scenarios. Next, axions, as light pseudo-Nambu-Goldstone bosons, are susceptible to quantum fluctuations in the early universe that lead to isocurvature perturbations, which are constrained by observations of the cosmic microwave background (CMB). We ask what it would take to allow axion models in the face of these strong CMB bounds. We revisit models where inflationary dynamics modify the axion potential and discuss how isocurvature bounds can be relaxed, elucidating the difficulties in these constructions. Avoiding disruption of inflationary dynamics provides important limits on the parameter space. Finally, PBHs have received interest in part due to observations by LIGO of merging black hole binaries. We ask how these PBHs could arise through inflationary models and investigate the opportunity for corroboration through experimental probes of gravitational waves at pulsar timing arrays. We provide examples of theories that are already ruled out, theories that will soon be probed, and theories that will not be tested in the foreseeable future. The models that are most strongly constrained are those with relatively broad primordial power spectra.

Climate change impacts on tree ranges: model intercomparison facilitates understanding and quantification of uncertainty.

PubMed

Cheaib, Alissar; Badeau, Vincent; Boe, Julien; Chuine, Isabelle; Delire, Christine; Dufrêne, Eric; François, Christophe; Gritti, Emmanuel S; Legay, Myriam; Pagé, Christian; Thuiller, Wilfried; Viovy, Nicolas; Leadley, Paul

2012-06-01

Model-based projections of shifts in tree species range due to climate change are becoming an important decision support tool for forest management. However, poorly evaluated sources of uncertainty require more scrutiny before relying heavily on models for decision-making. We evaluated uncertainty arising from differences in model formulations of tree response to climate change based on a rigorous intercomparison of projections of tree distributions in France. We compared eight models ranging from niche-based to process-based models. On average, models project large range contractions of temperate tree species in lowlands due to climate change. There was substantial disagreement between models for temperate broadleaf deciduous tree species, but differences in the capacity of models to account for rising CO(2) impacts explained much of the disagreement. There was good quantitative agreement among models concerning the range contractions for Scots pine. For the dominant Mediterranean tree species, Holm oak, all models foresee substantial range expansion. © 2012 Blackwell Publishing Ltd/CNRS.

Quantifying changes in flooding and habitats in the Tonle Sap Lake (Cambodia) caused by water infrastructure development and climate change in the Mekong Basin.

PubMed

Arias, Mauricio E; Cochrane, Thomas A; Piman, Thanapon; Kummu, Matti; Caruso, Brian S; Killeen, Timothy J

2012-12-15

The economic value of the Tonle Sap Lake Floodplain to Cambodia is arguably among the highest provided to a nation by a single ecosystem around the world. Nonetheless, the Mekong River Basin is changing rapidly due to accelerating water infrastructure development (hydropower, irrigation, flood control, and water supply) and climate change, bringing considerable modifications to the flood pulse of the Tonle Sap Lake in the foreseeable future. This paper presents research conducted to determine how the historical flooding regime, together with human action, influenced landscape patterns of habitats in the Tonle Sap Lake, and how these habitats might shift as a result of hydrological changes. Maps of water depth, annual flood duration, and flood frequency were created for recent historical hydrological conditions and for simulated future scenarios of water infrastructure development and climate change. Relationships were then established between the historical flood maps and land cover, and these were subsequently applied to assess potential changes to habitat cover in future decades. Five habitat groups were clearly distinguishable based on flood regime, physiognomic patterns, and human activity: (1) Open water, flooded for 12 months in an average hydrological year; (2) Gallery forest, with flood duration of 9 months annually; (3) Seasonally flooded habitats, flooded 5-8 months and dominated by shrublands and grasslands; (4) transitional habitats, flooded 1-5 months and dominated by abandoned agricultural fields, receding rice/floating rice, and lowland grasslands; and (5) Rainfed habitats, flooded up to 1 month and consisting mainly of wet season rice fields and village crops. It was found that water infrastructure development could increase the area of open water (+18 to +21%) and the area of rainfed habitats (+10 to +14%), while reducing the area covered with seasonally flooded habitats (-13 to -22%) and gallery forest (-75 to -83%). Habitat cover shifts as a result of climate change include a net increase of open water (2-21%), as well as a reduction of rainfed habitats by 2-5% and seasonally flooded habitats by 5-11%. Findings from this study will help guide on-going and future conservation and restoration efforts throughout this unique and critical ecosystem. Copyright © 2012 Elsevier Ltd. All rights reserved.

The Ethics of Big Data: Current and Foreseeable Issues in Biomedical Contexts.

PubMed

Mittelstadt, Brent Daniel; Floridi, Luciano

2016-04-01

The capacity to collect and analyse data is growing exponentially. Referred to as 'Big Data', this scientific, social and technological trend has helped create destabilising amounts of information, which can challenge accepted social and ethical norms. Big Data remains a fuzzy idea, emerging across social, scientific, and business contexts sometimes seemingly related only by the gigantic size of the datasets being considered. As is often the case with the cutting edge of scientific and technological progress, understanding of the ethical implications of Big Data lags behind. In order to bridge such a gap, this article systematically and comprehensively analyses academic literature concerning the ethical implications of Big Data, providing a watershed for future ethical investigations and regulations. Particular attention is paid to biomedical Big Data due to the inherent sensitivity of medical information. By means of a meta-analysis of the literature, a thematic narrative is provided to guide ethicists, data scientists, regulators and other stakeholders through what is already known or hypothesised about the ethical risks of this emerging and innovative phenomenon. Five key areas of concern are identified: (1) informed consent, (2) privacy (including anonymisation and data protection), (3) ownership, (4) epistemology and objectivity, and (5) 'Big Data Divides' created between those who have or lack the necessary resources to analyse increasingly large datasets. Critical gaps in the treatment of these themes are identified with suggestions for future research. Six additional areas of concern are then suggested which, although related have not yet attracted extensive debate in the existing literature. It is argued that they will require much closer scrutiny in the immediate future: (6) the dangers of ignoring group-level ethical harms; (7) the importance of epistemology in assessing the ethics of Big Data; (8) the changing nature of fiduciary relationships that become increasingly data saturated; (9) the need to distinguish between 'academic' and 'commercial' Big Data practices in terms of potential harm to data subjects; (10) future problems with ownership of intellectual property generated from analysis of aggregated datasets; and (11) the difficulty of providing meaningful access rights to individual data subjects that lack necessary resources. Considered together, these eleven themes provide a thorough critical framework to guide ethical assessment and governance of emerging Big Data practices.

Storm surges - a globally distributed risk, and the case of Hamburg (Invited)

NASA Astrophysics Data System (ADS)

von Storch, H.

2010-12-01

For most coasts, storm surges represent the major geo risk. A map of these risks shows that the phenomenon is really a global phenomenon. However, when discussing dynamics, risks, adaptation, future perspectives as well as aggravating local factors, the situation is mostly perceived as a regional or even local phenomenon. In the talk first the different manifestations of storm surges, mainly at mid latitudes and in the tropics are discussed; the historical perceptions of such events are touched upon, projection for the future presented and issues of management and adaptation discussed. In a second part, a specific situation is discussed, namely the case of Hamburg since 1750. This case is particularly interesting, because specific analysis has been done for past variability, possible future developments; local perceptions of risk and un-conventional mitigation measures. For the time prior to 1850, coastal defence failure was a regular phenomenon; from about 1850-1960 coastal defence was hardly challenged, and after the 1962 storm surge heights rose to levels never recorded before. The most likely causes for this change are modifications of the Elbe estuary, related to coastal defence and improving the shipping channel. Anthropogenic climate change may lead in the future to even higher storm surges (mainly because of increased sea level). While for the foreseeable future, conventional measures will be sufficient for ensuring coastal defence, a mitigation option of local mitigation of high water levels seems to be available. This may be achieved though the "tidal Elbe project", which was designed to reduce upstream river sediment transport.

Life sciences today and tomorrow: emerging biotechnologies.

PubMed

Williamson, E Diane

2017-08-01

The purpose of this review is to survey current, emerging and predicted future biotechnologies which are impacting, or are likely to impact in the future on the life sciences, with a projection for the coming 20 years. This review is intended to discuss current and future technical strategies, and to explore areas of potential growth during the foreseeable future. Information technology approaches have been employed to gather and collate data. Twelve broad categories of biotechnology have been identified which are currently impacting the life sciences and will continue to do so. In some cases, technology areas are being pushed forward by the requirement to deal with contemporary questions such as the need to address the emergence of anti-microbial resistance. In other cases, the biotechnology application is made feasible by advances in allied fields in biophysics (e.g. biosensing) and biochemistry (e.g. bio-imaging). In all cases, the biotechnologies are underpinned by the rapidly advancing fields of information systems, electronic communications and the World Wide Web together with developments in computing power and the capacity to handle extensive biological data. A rationale and narrative is given for the identification of each technology as a growth area. These technologies have been categorized by major applications, and are discussed further. This review highlights: Biotechnology has far-reaching applications which impinge on every aspect of human existence. The applications of biotechnology are currently wide ranging and will become even more diverse in the future. Access to supercomputing facilities and the ability to manipulate large, complex biological datasets, will significantly enhance knowledge and biotechnological development.

The present and the future of breast cancer burden in the Kingdom of Saudi Arabia.

PubMed

Ibrahim, Ezzeldin M; Zeeneldin, Ahmed A; Sadiq, Bakr Bin; Ezzat, Adnan A

2008-01-01

Despite the low cancer incidence in the Kingdom of Saudi Arabia (KSA), the country must be ready to face the challenge of foreseeable increase in cancer burden attributed to growth and aging of population. This work was designed to study female breast cancer as a model to assess future cancer burden and the impact on healthcare resources. Cancer statistics for the KSA were compared with that for the USA. The Joinpoint regression program was used to identify changes in secular trends, while the GLOBOCAN 2002 software projected future incidence and mortality. In the KSA, the age-standardized cancer rate (ASR) is 61 per 100,000 population, while the median age at diagnosis is 54 and 49 years for men and women, respectively. Fitting the ASR for breast cancer did not show any significant trend over a 10-year calendar period (16.2-18.2 per 100,000), a pattern that was similar to that for the USA in the prescreening mammography era. Considering the growth and aging of population and using conservative estimates for the annual percent change in incidence (increase) and mortality (decrease) by 2025, incidence and mortality cases are expected to increase by about 350% and 160%, respectively. In developing countries, future cancer rates could demonstrate a considerable increase and enormous demands on healthcare resources. The present work may provide an impetus to study other prevalent cancer types particularly in developing countries.

Agricultural Water Use under Global Change

NASA Astrophysics Data System (ADS)

Zhu, T.; Ringler, C.; Rosegrant, M. W.

2008-12-01

Irrigation is by far the single largest user of water in the world and is projected to remain so in the foreseeable future. Globally, irrigated agricultural land comprises less than twenty percent of total cropland but produces about forty percent of the world's food. Increasing world population will require more food and this will lead to more irrigation in many areas. As demands increase and water becomes an increasingly scarce resource, agriculture's competition for water with other economic sectors will be intensified. This water picture is expected to become even more complex as climate change will impose substantial impacts on water availability and demand, in particular for agriculture. To better understand future water demand and supply under global change, including changes in demographic, economic and technological dimensions, the water simulation module of IMPACT, a global water and food projection model developed at the International Food Policy Research Institute, is used to analyze future water demand and supply in agricultural and several non-agricultural sectors using downscaled GCM scenarios, based on water availability simulation done with a recently developed semi-distributed global hydrological model. Risk analysis is conducted to identify countries and regions where future water supply reliability for irrigation is low, and food security may be threatened in the presence of climate change. Gridded shadow values of irrigation water are derived for global cropland based on an optimization framework, and they are used to illustrate potential irrigation development by incorporating gridded water availability and existing global map of irrigation areas.

Effect of Inorganic and Organic Carbon Enrichments (DIC and DOC) on the Photosynthesis and Calcification Rates of Two Calcifying Green Algae from a Caribbean Reef Lagoon.

PubMed

Meyer, Friedrich W; Schubert, Nadine; Diele, Karen; Teichberg, Mirta; Wild, Christian; Enríquez, Susana

2016-01-01

Coral reefs worldwide are affected by increasing dissolved inorganic carbon (DIC) and organic carbon (DOC) concentrations due to ocean acidification (OA) and coastal eutrophication. These two stressors can occur simultaneously, particularly in near-shore reef environments with increasing anthropogenic pressure. However, experimental studies on how elevated DIC and DOC interact are scarce and fundamental to understanding potential synergistic effects and foreseeing future changes in coral reef function. Using an open mesocosm experiment, the present study investigated the impact of elevated DIC (pHNBS: 8.2 and 7.8; pCO2: 377 and 1076 μatm) and DOC (added as 833 μmol L-1 of glucose) on calcification and photosynthesis rates of two common calcifying green algae, Halimeda incrassata and Udotea flabellum, in a shallow reef environment. Our results revealed that under elevated DIC, algal photosynthesis decreased similarly for both species, but calcification was more affected in H. incrassata, which also showed carbonate dissolution rates. Elevated DOC reduced photosynthesis and calcification rates in H. incrassata, while in U. flabellum photosynthesis was unaffected and thalus calcification was severely impaired. The combined treatment showed an antagonistic effect of elevated DIC and DOC on the photosynthesis and calcification rates of H. incrassata, and an additive effect in U. flabellum. We conclude that the dominant sand dweller H. incrassata is more negatively affected by both DIC and DOC enrichments, but that their impact could be mitigated when they occur simultaneously. In contrast, U. flabellum can be less affected in coastal eutrophic waters by elevated DIC, but its contribution to reef carbonate sediment production could be further reduced. Accordingly, while the capacity of environmental eutrophication to exacerbate the impact of OA on algal-derived carbonate sand production seems to be species-specific, significant reductions can be expected under future OA scenarios, with important consequences for beach erosion and coastal sediment dynamics.

Assessing environmental risks for high intensity agriculture using the material flow analysis method--a case study of the Dongting Lake basin in South Central China.

PubMed

Yin, Guanyi; Liu, Liming; Yuan, Chengcheng

2015-07-01

This study primarily examined the assessment of environmental risk in high intensity agricultural areas. Dongting Lake basin was taken as a case study, which is one of the major grain producing areas in China. Using data obtained from 1989 to 2012, we applied Material Flow Analysis (MFA) to show the material consumption, pollutant output and production storage in the agricultural-environmental system and assessed the environmental risk index on the basis of the MFA results. The results predicted that the status of the environmental quality of the Dongting Lake area is unsatisfactory for the foreseeable future. The direct material input (DMI) declined by 13.9%, the domestic processed output (DPO) increased by 28.21%, the intensity of material consumption (IMC) decreased by 36.7%, the intensity of material discharge (IMD) increased by 10%, the material productivity (MP) increased by 27 times, the environmental efficiency (EE) increased by 15.31 times, and the material storage (PAS) increased by 0.23%. The DMI and DPO was higher at rural places on the edge of cities, whereas the risk of urban agriculture has arisen due to the higher increasing rate of DMI and DPO in cities compared with the counties. The composite environmental risk index increased from 0.33 to 0.96, indicating that the total environmental risk changed gradually but seriously during the 24 years assessed. The driving factors that affect environmental risk in high intensity agriculture can be divided into five classes: social, economic, human, natural and disruptive incidents. This study discussed a number of effective measures for protecting the environment while ensuring food production yields. Additional research in other areas and certain improvements of this method in future studies may be necessary to develop a more effective method of managing and controlling agricultural-environmental interactions.

Current Analogues of Future Climate Indicate the Likely Response of a Sensitive Montane Tropical Avifauna to a Warming World

PubMed Central

Anderson, Alexander S.; Storlie, Collin J.; Shoo, Luke P.; Pearson, Richard G.; Williams, Stephen E.

2013-01-01

Among birds, tropical montane species are likely to be among the most vulnerable to climate change, yet little is known about how climate drives their distributions, nor how to predict their likely responses to temperature increases. Correlative models of species’ environmental niches have been widely used to predict changes in distribution, but direct tests of the relationship between key variables, such as temperature, and species’ actual distributions are few. In the absence of historical data with which to compare observations and detect shifts, space-for-time substitutions, where warmer locations are used as analogues of future conditions, offer an opportunity to test for species’ responses to climate. We collected density data for rainforest birds across elevational gradients in northern and southern subregions within the Australian Wet Tropics (AWT). Using environmental optima calculated from elevational density profiles, we detected a significant elevational difference between the two regions in ten of 26 species. More species showed a positive (19 spp.) than negative (7 spp.) displacement, with a median difference of ∼80.6 m across the species analysed that is concordant with that expected due to latitudinal temperature differences (∼75.5 m). Models of temperature gradients derived from broad-scale climate surfaces showed comparable performance to those based on in-situ measurements, suggesting the former is sufficient for modeling impacts. These findings not only confirm temperature as an important factor driving elevational distributions of these species, but also suggest species will shift upslope to track their preferred environmental conditions. Our approach uses optima calculated from elevational density profiles, offering a data-efficient alternative to distribution limits for gauging climate constraints, and is sensitive enough to detect distribution shifts in this avifauna in response to temperature changes of as little as 0.4 degrees. We foresee important applications in the urgent task of detecting and monitoring impacts of climate change on montane tropical biodiversity. PMID:23936005

Numerical Simulation of Non-Rotating and Rotating Coolant Channel Flow Fields. Part 1

NASA Technical Reports Server (NTRS)

Rigby, David L.

2000-01-01

Future generations of ultra high bypass-ratio jet engines will require far higher pressure ratios and operating temperatures than those of current engines. For the foreseeable future, engine materials will not be able to withstand the high temperatures without some form of cooling. In particular the turbine blades, which are under high thermal as well as mechanical loads, must be cooled. Cooling of turbine blades is achieved by bleeding air from the compressor stage of the engine through complicated internal passages in the turbine blades (internal cooling, including jet-impingement cooling) and by bleeding small amounts of air into the boundary layer of the external flow through small discrete holes on the surface of the blade (film cooling and transpiration cooling). The cooling must be done using a minimum amount of air or any increases in efficiency gained through higher operating temperature will be lost due to added load on the compressor stage. Turbine cooling schemes have traditionally been based on extensive empirical data bases, quasi-one-dimensional computational fluid dynamics (CFD) analysis, and trial and error. With improved capabilities of CFD, these traditional methods can be augmented by full three-dimensional simulations of the coolant flow to predict in detail the heat transfer and metal temperatures. Several aspects of turbine coolant flows make such application of CFD difficult, thus a highly effective CFD methodology must be used. First, high resolution of the flow field is required to attain the needed accuracy for heat transfer predictions, making highly efficient flow solvers essential for such computations. Second, the geometries of the flow passages are complicated but must be modeled accurately in order to capture all important details of the flow. This makes grid generation and grid quality important issues. Finally, since coolant flows are turbulent and separated the effects of turbulence must be modeled with a low Reynolds number turbulence model to accurately predict details of heat transfer.

Effect of Inorganic and Organic Carbon Enrichments (DIC and DOC) on the Photosynthesis and Calcification Rates of Two Calcifying Green Algae from a Caribbean Reef Lagoon

PubMed Central

Diele, Karen; Teichberg, Mirta; Wild, Christian

2016-01-01

Coral reefs worldwide are affected by increasing dissolved inorganic carbon (DIC) and organic carbon (DOC) concentrations due to ocean acidification (OA) and coastal eutrophication. These two stressors can occur simultaneously, particularly in near-shore reef environments with increasing anthropogenic pressure. However, experimental studies on how elevated DIC and DOC interact are scarce and fundamental to understanding potential synergistic effects and foreseeing future changes in coral reef function. Using an open mesocosm experiment, the present study investigated the impact of elevated DIC (pHNBS: 8.2 and 7.8; pCO2: 377 and 1076 μatm) and DOC (added as 833 μmol L-1 of glucose) on calcification and photosynthesis rates of two common calcifying green algae, Halimeda incrassata and Udotea flabellum, in a shallow reef environment. Our results revealed that under elevated DIC, algal photosynthesis decreased similarly for both species, but calcification was more affected in H. incrassata, which also showed carbonate dissolution rates. Elevated DOC reduced photosynthesis and calcification rates in H. incrassata, while in U. flabellum photosynthesis was unaffected and thalus calcification was severely impaired. The combined treatment showed an antagonistic effect of elevated DIC and DOC on the photosynthesis and calcification rates of H. incrassata, and an additive effect in U. flabellum. We conclude that the dominant sand dweller H. incrassata is more negatively affected by both DIC and DOC enrichments, but that their impact could be mitigated when they occur simultaneously. In contrast, U. flabellum can be less affected in coastal eutrophic waters by elevated DIC, but its contribution to reef carbonate sediment production could be further reduced. Accordingly, while the capacity of environmental eutrophication to exacerbate the impact of OA on algal-derived carbonate sand production seems to be species-specific, significant reductions can be expected under future OA scenarios, with important consequences for beach erosion and coastal sediment dynamics. PMID:27487195

Current analogues of future climate indicate the likely response of a sensitive montane tropical avifauna to a warming world.

PubMed

Anderson, Alexander S; Storlie, Collin J; Shoo, Luke P; Pearson, Richard G; Williams, Stephen E

2013-01-01

Among birds, tropical montane species are likely to be among the most vulnerable to climate change, yet little is known about how climate drives their distributions, nor how to predict their likely responses to temperature increases. Correlative models of species' environmental niches have been widely used to predict changes in distribution, but direct tests of the relationship between key variables, such as temperature, and species' actual distributions are few. In the absence of historical data with which to compare observations and detect shifts, space-for-time substitutions, where warmer locations are used as analogues of future conditions, offer an opportunity to test for species' responses to climate. We collected density data for rainforest birds across elevational gradients in northern and southern subregions within the Australian Wet Tropics (AWT). Using environmental optima calculated from elevational density profiles, we detected a significant elevational difference between the two regions in ten of 26 species. More species showed a positive (19 spp.) than negative (7 spp.) displacement, with a median difference of ∼80.6 m across the species analysed that is concordant with that expected due to latitudinal temperature differences (∼75.5 m). Models of temperature gradients derived from broad-scale climate surfaces showed comparable performance to those based on in-situ measurements, suggesting the former is sufficient for modeling impacts. These findings not only confirm temperature as an important factor driving elevational distributions of these species, but also suggest species will shift upslope to track their preferred environmental conditions. Our approach uses optima calculated from elevational density profiles, offering a data-efficient alternative to distribution limits for gauging climate constraints, and is sensitive enough to detect distribution shifts in this avifauna in response to temperature changes of as little as 0.4 degrees. We foresee important applications in the urgent task of detecting and monitoring impacts of climate change on montane tropical biodiversity.

REDUCTIONS WITHOUT REGRET: DEFINING THE NEEDED CAPABILITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swegle, J.; Tincher, D.

This is the second of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as somemore » closing thoughts for the future. This paper begins with a discussion of the current nuclear force and the plans and procurement programs for the modernization of that force. Current weapon systems and warheads were conceived and built decades ago, and procurement programs have begun for the modernization or replacement of major elements of the nuclear force: the heavy bomber, the air-launched cruise missile, the ICBMs, and the ballistic-missile submarines. In addition, the Nuclear Weapons Council has approved a new framework for nuclear-warhead life extension not fully fleshed out yet that aims to reduce the current number of nuclear explosives from seven to five, the so-called 3+2 vision. This vision includes three interoperable warheads for both ICBMs and SLBMs (thus eliminating one backup weapon) and two warheads for aircraft delivery (one gravity bomb and one cruise-missile, eliminating a second backup gravity bomb). This paper also includes a discussion of the current and near-term nuclear-deterrence mission, both global and regional, and offers some observations on future of the strategic deterrence mission and the challenges of regional and extended nuclear deterrence.« less

Prospective Optimization with Limited Resources

PubMed Central

Snider, Joseph; Lee, Dongpyo; Poizner, Howard; Gepshtein, Sergei

2015-01-01

The future is uncertain because some forthcoming events are unpredictable and also because our ability to foresee the myriad consequences of our own actions is limited. Here we studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of an exponentially expanding number of prospects on a branching multivalued visual stimulus. A triangular grid of disks of different sizes scrolled down a touchscreen at a variable speed. The larger disks represented larger rewards. The task was to maximize the cumulative reward by touching one disk at a time in a rapid sequence, forming an upward path across the grid, while every step along the path constrained the part of the grid accessible in the future. This task captured some of the complexity of natural behavior in the risky and dynamic world, where ongoing decisions alter the landscape of future rewards. By comparing human behavior with behavior of ideal actors, we identified the strategies used by humans in terms of how far into the future they looked (their “depth of computation”) and how often they attempted to incorporate new information about the future rewards (their “recalculation period”). We found that, for a given task difficulty, humans traded off their depth of computation for the recalculation period. The form of this tradeoff was consistent with a complete, brute-force exploration of all possible paths up to a resource-limited finite depth. A step-by-step analysis of the human behavior revealed that participants took into account very fine distinctions between the future rewards and that they abstained from some simple heuristics in assessment of the alternative paths, such as seeking only the largest disks or avoiding the smaller disks. The participants preferred to reduce their depth of computation or increase the recalculation period rather than sacrifice the precision of computation. PMID:26367309

Prospective Optimization with Limited Resources.

PubMed

Snider, Joseph; Lee, Dongpyo; Poizner, Howard; Gepshtein, Sergei

2015-09-01

The future is uncertain because some forthcoming events are unpredictable and also because our ability to foresee the myriad consequences of our own actions is limited. Here we studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of an exponentially expanding number of prospects on a branching multivalued visual stimulus. A triangular grid of disks of different sizes scrolled down a touchscreen at a variable speed. The larger disks represented larger rewards. The task was to maximize the cumulative reward by touching one disk at a time in a rapid sequence, forming an upward path across the grid, while every step along the path constrained the part of the grid accessible in the future. This task captured some of the complexity of natural behavior in the risky and dynamic world, where ongoing decisions alter the landscape of future rewards. By comparing human behavior with behavior of ideal actors, we identified the strategies used by humans in terms of how far into the future they looked (their "depth of computation") and how often they attempted to incorporate new information about the future rewards (their "recalculation period"). We found that, for a given task difficulty, humans traded off their depth of computation for the recalculation period. The form of this tradeoff was consistent with a complete, brute-force exploration of all possible paths up to a resource-limited finite depth. A step-by-step analysis of the human behavior revealed that participants took into account very fine distinctions between the future rewards and that they abstained from some simple heuristics in assessment of the alternative paths, such as seeking only the largest disks or avoiding the smaller disks. The participants preferred to reduce their depth of computation or increase the recalculation period rather than sacrifice the precision of computation.

Implantable brain computer interface: challenges to neurotechnology translation.

PubMed

Konrad, Peter; Shanks, Todd

2010-06-01

This article reviews three concepts related to implantable brain computer interface (BCI) devices being designed for human use: neural signal extraction primarily for motor commands, signal insertion to restore sensation, and technological challenges that remain. A significant body of literature has occurred over the past four decades regarding motor cortex signal extraction for upper extremity movement or computer interface. However, little is discussed regarding postural or ambulation command signaling. Auditory prosthesis research continues to represent the majority of literature on BCI signal insertion. Significant hurdles continue in the technological translation of BCI implants. These include developing a stable neural interface, significantly increasing signal processing capabilities, and methods of data transfer throughout the human body. The past few years, however, have provided extraordinary human examples of BCI implant potential. Despite technological hurdles, proof-of-concept animal and human studies provide significant encouragement that BCI implants may well find their way into mainstream medical practice in the foreseeable future.

The Aral Sea Disaster

NASA Astrophysics Data System (ADS)

Micklin, Philip

2007-05-01

The Aral Sea is a huge terminal lake located among the deserts of Central Asia. Over the past 10 millennia, it has repeatedly filled and dried, owing both to natural and human forces. The most recent desiccation started in the early 1960s and owes overwhelmingly to the expansion of irrigation that has drained its two tributary rivers. Lake level has fallen 23 m, area shrunk 74%, volume decreased 90%, and salinity grew from 10 to more than 100g/l, causing negative ecological changes, including decimation of native fish species, initiation of dust/salt storms, degradation of deltaic biotic communities, and climate change around the former shoreline. The population residing around the lake has also been negatively impacted. There is little hope in the foreseeable future to fully restore the Aral Sea, but measures to preserve/rehabilitate parts of the water body and the deltas are feasible.

[Poliomyelitis--Challenges for the Last Mile of the Eradication Programme].

PubMed

Müller, O; Jahn, A; Razum, O

2016-04-01

The World Health Organisation initiated the Global Polio Eradication Initiative in the year 1988. With the large-scale application of routine and mass vaccinations in children under the age of 5 years, polio disease has become restricted to only 3 endemic countries (Afghanistan, Pakistan and Nigeria) by today. However, since the beginning of the 21st century, increasing numbers of secondary polio epidemics have been observed which were triggered through migration, political turmoil and weak health systems. In addition, there emerged serious technical (e. g., back-mutations of oral vaccine virus to wild virus) and socio-political (refusal of vaccinations in Muslim populations of Nigeria and Pakistan) problems with the vaccination in the remaining endemic countries. It thus appears questionable if the current eradiation initiative will reach its goal in the foreseeable future. © Georg Thieme Verlag KG Stuttgart · New York.

Simplified DFT methods for consistent structures and energies of large systems

NASA Astrophysics Data System (ADS)

Caldeweyher, Eike; Gerit Brandenburg, Jan

2018-05-01

Kohn–Sham density functional theory (DFT) is routinely used for the fast electronic structure computation of large systems and will most likely continue to be the method of choice for the generation of reliable geometries in the foreseeable future. Here, we present a hierarchy of simplified DFT methods designed for consistent structures and non-covalent interactions of large systems with particular focus on molecular crystals. The covered methods are a minimal basis set Hartree–Fock (HF-3c), a small basis set screened exchange hybrid functional (HSE-3c), and a generalized gradient approximated functional evaluated in a medium-sized basis set (B97-3c), all augmented with semi-classical correction potentials. We give an overview on the methods design, a comprehensive evaluation on established benchmark sets for geometries and lattice energies of molecular crystals, and highlight some realistic applications on large organic crystals with several hundreds of atoms in the primitive unit cell.

Cost-Effective Fabrication of Wettability Gradient Copper Surface by Screen Printing and its Application to Condensation Heat Transfer

NASA Astrophysics Data System (ADS)

Leu, Tzong-Shyng; Huang, Hung-Ming; Huang, Ding-Jun

2016-06-01

In this paper, wettability gradient pattern is applied to condensation heat transfer on a copper tube surface. For this application, the vital issue is how to fabricate gradient patterns on a curve tube surface to accelerate the droplet collection efficiently. For this purpose, novel fabrication processes are developed to form wettability gradient patterns on a curve copper tube surface by using roller screen printing surface modification techniques. The roller screen printing surface modification techniques can easily realize wettability gradient surfaces with superhydrophobicity and superhydrophilicity on a copper tube surface. Experimental results show the droplet nucleation sites, movement and coalescence toward the collection areas can be effectively controlled which can assist in removing the condensation water from the surface. The effectiveness of droplet collection is appropriate for being applied to condensation heat transfer in the foreseeable future.

Characteristics of peri-urbanization of a secondary city: a challenge in recent urban development

NASA Astrophysics Data System (ADS)

Rahayu, P.; Mardiansjah, F. H.

2018-03-01

Urbanization process creates a tremendous spatial phenomenon since the last century. Especially for the country of the South, the phenomenon is still relevant to the situation today and the processes will still going until the foreseeable future. The metropolitan-based of urbanization process involves the development of peri-urban areas, which could be defined as transitional zones between city and rural areas characterized by integrated mixed-structures of agricultural and non-agricultural activities. This article reveals the characteristics of periurbanization process of an emerging secondary city in Java, which uses Surakarta, the second largest city in Central Java Province based on the population size, as the case. During the last ten years, there have been significant changes in peri-urban areas regarding urban population, land use, and urban activities that strengthening the contribution of the urban component into peri-urban system.

The future of human DNA vaccines

PubMed Central

Li, Lei; Saade, Fadi; Petrovsky, Nikolai

2012-01-01

DNA vaccines have evolved greatly over the last 20 years since their invention, but have yet to become a competitive alternative to conventional protein or carbohydrate based human vaccines. Whilst safety concerns were an initial barrier, the Achilles heel of DNA vaccines remains their poor immunogenicity when compared to protein vaccines. A wide variety of strategies have been developed to optimize DNA vaccine immunogenicity, including codon optimization, genetic adjuvants, electroporation and sophisticated prime-boost regimens, with each of these methods having its advantages and limitations. Whilst each of these methods has contributed to incremental improvements in DNA vaccine efficacy, more is still needed if human DNA vaccines are to succeed commercially. This review foresees a final breakthrough in human DNA vaccines will come from application of the latest cutting-edge technologies, including “epigenetics” and “omics” approaches, alongside traditional techniques to improve immunogenicity such as adjuvants and electroporation, thereby overcoming the current limitations of DNA vaccines in humans PMID:22981627

Allostery: An Overview of Its History, Concepts, Methods, and Applications.

PubMed

Liu, Jin; Nussinov, Ruth

2016-06-01

The concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904) to the birth of allostery by Monod and Jacob (1961). We describe the evolution of the allostery concept, from a conformational change in a two-state model (1965, 1966) to dynamic allostery in the ensemble model (1999); from multi-subunit (1965) proteins to all proteins (2004). We highlight the current available methods to study allostery and their applications in studies of conformational mechanisms, disease, and allosteric drug discovery. We outline the challenges and future directions that we foresee. Altogether, this Editorial narrates the history of this fundamental concept in the life sciences, its significance, methodologies to detect and predict it, and its application in a broad range of living systems.

Best practicable means (BPM) and as low as reasonably practicable (ALARP) in action at Sellafield.

PubMed

Morley, Bob

2004-03-01

Operators within the UK nuclear industry are required to employ 'best practicable means' (BPM) to control and minimise radioactive discharges. The requirement for the use of BPM is in order to ensure that doses from discharges are as low as reasonably practicable (ALARP). This facet is increasingly becoming the principal feature of discharge authorisations issued by the Environment Agencies under the Radioactive Substances Act, 1993 (RSA 93), which are enforceable by law. It is important to state at the outset, however, that scientific assessments to date indicate that there are no expectations of environmental harm from authorised discharges, even where those discharges have historically been up to two orders of magnitude higher than current levels. There is also no evidence to indicate that foreseeable future discharges from the Sellafield site will make any contribution to environmental harm.

The global tobacco disease pandemic: nature, causes, and cures.

PubMed

Warner, K E; Mackay, J

2006-01-01

Tobacco use kills 5 million citizens globally every year. The World Health Organization (WHO) projects that the number of deaths will double just 15 years from now. Tobacco will then constitute the leading cause of death in the developing world, as it already is in developed countries today. This paper describes the nature and extent of the tobacco pandemic, characteristics of the global tobacco industry, and national and international efforts to diminish the toll of tobacco. The review includes examination of the economic and political strategies employed by the multinational tobacco industry to increase cigarette consumption, as well as the policies that governments have adopted to combat smoking. The most promising development is the new Framework Convention on Tobacco Control, WHO's first-ever international health treaty. While aggressive tobacco control policies can and will diminish the toll of tobacco, the prospects for the foreseeable future appear grim.

Geochemical survey of the western coal regions; first annual progress report, July 1974

USGS Publications Warehouse

Connor, Jon J.; Tidball, Ronald R.; Erdman, James A.; Ebens, Richard J.; Keith, John R.; Anderson, Barbara M.

1974-01-01

National energy needs have precipitated an increased interest in the development of a large coal-based electric power industry in the western United States. This anticipated development has, in turn, spawned a great deal of interest in the environmental impact consequent upon the mining and utilization of these coal supplies. Numerous studies directed to assessing this impact are underway or are in the planning stages by agencies of government at all levels as well as by educational institutions and private firms. It is expected that such studies will continue to increase in number in the foreseeable future. Some idea of the diversity of this work is given by Boulding (1974), who surveyed a broad spectrum of people and organizations concerned about the environmental impact of coal development in the Northern Great Plains. This survey included over 50 governmental organizations and over 50 nongovernmental organizations.

The Global International Waters Assessment for the Pacific Islands: aspects of transboundary, water shortage, and coastal fisheries issues.

PubMed

South, G Robin; Skelton, Posa A; Veitayaki, Joeli; Resture, Alan; Carpenter, Clive; Pratt, Craig; Lawedrau, Alena

2004-02-01

Aspects of transboundary, water shortage, and fisheries issues are discussed in the context of the recently completed Global International Waters Assessment (GIWA) for the Pacific Islands. The region encompasses some 30 million km2 and approximately 12% of the world's ocean space, and features great geographic, demographic and developmental diversity. Global change, especially sea level rise and sea surface temperature increases, is the dominant transboundary concern as it impacts all aspects of life. Water shortage and unsustainable fishing issues are selected for discussion, as they will dominate the region into the foreseeable future, and they are illustrated with examples from Fiji, Kiribati, and Tonga. The environmental impacts are exacerbated by socioeconomic issues such as high population growth rates, urban drift, the breakdown of traditional life styles and the rapid adoption of the cash economy. Policy options that may assist in addressing these issues are proposed.

Advanced protein formulations

PubMed Central

Wang, Wei

2015-01-01

It is well recognized that protein product development is far more challenging than that for small-molecule drugs. The major challenges include inherent sensitivity to different types of stresses during the drug product manufacturing process, high rate of physical and chemical degradation during long-term storage, and enhanced aggregation and/or viscosity at high protein concentrations. In the past decade, many novel formulation concepts and technologies have been or are being developed to address these product development challenges for proteins. These concepts and technologies include use of uncommon/combination of formulation stabilizers, conjugation or fusion with potential stabilizers, site-specific mutagenesis, and preparation of nontraditional types of dosage forms—semiaqueous solutions, nonfreeze-dried solid formulations, suspensions, and other emerging concepts. No one technology appears to be mature, ideal, and/or adequate to address all the challenges. These gaps will likely remain in the foreseeable future and need significant efforts for ultimate resolution. PMID:25858529

Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential

PubMed Central

Watanabe, Tokiko; Zhong, Gongxun; Russell, Colin A.; Nakajima, Noriko; Hatta, Masato; Hanson, Anthony; McBride, Ryan; Burke, David F.; Takahashi, Kenta; Fukuyama, Satoshi; Tomita, Yuriko; Maher, Eileen A.; Watanabe, Shinji; Imai, Masaki; Neumann, Gabriele; Hasegawa, Hideki; Paulson, James C.; Smith, Derek J.; Kawaoka, Yoshihiro

2014-01-01

Summary Wild birds harbor a large gene pool of influenza A viruses that have the potential to cause influenza pandemics. Foreseeing and understanding this potential is important for effective surveillance. Our phylogenetic and geographic analyses revealed the global prevalence of avian influenza virus genes whose proteins differ only a few amino acids from the 1918 pandemic influenza virus, suggesting that 1918-like pandemic viruses may emerge in the future. To assess this risk, we generated and characterized a virus composed of avian influenza viral segments with high homology to the 1918 virus. This virus exhibited higher pathogenicity in mice and ferrets than an authentic avian influenza virus. Further, acquisition of seven amino acid substitutions in the viral polymerases and the hemagglutinin surface glycoprotein conferred respiratory droplet transmission to the 1918-like avian virus in ferrets, demonstrating that contemporary avian influenza viruses with 1918 virus-like proteins may have pandemic potential. PMID:24922572

Coordinated Management of Academic Health Centers.

PubMed

Balser, Jeffrey R; Stead, William W

2017-01-01

Academic health centers (AHCs) are the nation's primary resource for healthcare discovery, innovation, and training. US healthcare revenue growth has declined sharply since 2009, and is forecast to remain well below historic levels for the foreseeable future. As the cost of education and research at nearly all AHCs is heavily subsidized through large transfers from clinical care margins, our institutions face a mounting crisis. Choices centering on how to increase the cost-effectiveness of the AHC enterprise require unprecedented levels of alignment to preserve an environment that nurtures creativity. Management processes require governance models that clarify decision rights while harnessing the talents and the intellectual capital of a large, diverse enterprise to nimbly address unfamiliar organizational challenges. This paper describes key leadership tactics aimed at propelling AHCs along this journey - one that requires from all leaders a commitment to resilience, optimism, and willingness to embrace change.

The utilisation of engineered invert traps in the management of near bed solids in sewer networks.

PubMed

Ashley, R M; Tait, S J; Stovin, V R; Burrows, R; Framer, A; Buxton, A P; Blackwood, D J; Saul, A J; Blanksby, J R

2003-01-01

Large existing sewers are considerable assets which wastewater utilities will require to operate for the foreseeable future to maintain health and the quality of life in cities. Despite their existence for more than a century there is surprisingly little guidance available to manage these systems to minimise problems associated with in-sewer solids. A joint study has been undertaken in the UK, to refine and utilise new knowledge gained from field data, laboratory results and Computational Fluid Dynamics (CFD) simulations to devise cost beneficial engineering tools for the application of small invert traps to localise the deposition of sediments in sewers at accessible points for collection. New guidance has been produced for trap siting and this has been linked to a risk-cost-effectiveness assessment procedure to enable system operators to approach in-sewer sediment management pro-actively rather than reactively as currently happens.

[Embryo donation: why is there a delay in the implementation in France? A discussion on the practical, ethical and psychological dilemmas].

PubMed

Temstet, R; Devaux, A; Lourdel, E; Cabry, R; Brzakowski, M; Copin, H; Merviel, P

2011-01-01

Since 1999, French legislation has stipulated that embryo donation is one of the possibilities afforded to couples who have a surplus of cryopreserved embryos. Donation of embryos with no foreseeable future use by the genetic couple can therefore be given to infertile couples. In practice however, since the authorization of this novel Medically Assisted Reproduction technique, embryo donation is not widely performed in France even though it is not technically difficult. Why then is there reluctance towards the implementation of embryo donation in France? The aim of this article is to analyze the grounds for the delay in the realization of embryo donation in France. Our findings propose that a myriad of factors including organizational, ethical and psychological determinants have deterred the implementation of embryo donation in France. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

"Bare Branches" and the Marriage Market in Rural China: Preliminary Evidence from a village-level survey.

PubMed

Jin, Xiaoyi; Liu, Lige; Li, Yan; Feldman, Marcus W; Li, Shuzhuo

Using data from a village survey in rural China, this study explores the relationships between current prevalence of involuntary bachelorhood and its causes and social consequences at the village level. We find that bachelors, inter-county marriage and marriage fraud exist in all regions, and are expected to become more frequent with the increasing surplus of males born after 1980 entering the marriage market. The marriage squeeze and social problems related to the bachelors are more serious in less-developed western villages, and heterogeneity within central villages is significant. Economic and socio-demographic factors are shown to be the major causes of the prevalence of bachelors at the village level in contemporary rural China. Our findings confirm the negative consequences of the marriage squeeze, and effective policies are urgently needed to respond to and prevent more negative consequences of gender imbalance in the foreseeable future.

The power of collaboration: using internet-based tools to facilitate networking and benchmarking within a consortium of academic health centers.

PubMed

Korner, Eli J; Oinonen, Michael J; Browne, Robert C

2003-02-01

The University HealthSystem Consortium (UHC) represents a strategic alliance of 169 academic health centers and associated institutions engaged in knowledge sharing and idea-generation. The use of the Internet as a tool in the delivery of UHC's products and services has increased dramatically over the past year and will continue to increase during the foreseeable future. This paper examines the current state of UHC-member institution driven tools and services that utilize the Web as a fundamental component in their delivery. The evolution of knowledge management at UHC, its management information and reporting tools, and expansion of e-commerce provide real world examples of Internet use in health care delivery and management. Health care workers are using these Web-based tools to help manage rising costs and optimize patient outcomes. Policy, technical, and organizational issues must be resolved to facilitate rapid adoption of Internet applications.

Applications of piezoelectric materials in oilfield services.

PubMed

Goujon, Nicolas; Hori, Hiroshi; Liang, Kenneth K; Sinha, Bikash K

2012-09-01

Piezoelectric materials are used in many applications in the oilfield services industry. Four illustrative examples are given in this paper: marine seismic survey, precision pressure measurement, sonic logging-while-drilling, and ultrasonic bore-hole imaging. In marine seismics, piezoelectric hydrophones are deployed on a massive scale in a relatively benign environment. Hence, unit cost and device reliability are major considerations. The remaining three applications take place downhole in a characteristically harsh environment with high temperature and high pressure among other factors. The number of piezoelectric devices involved is generally small but otherwise highly valued. The selection of piezoelectric materials is limited, and the devices have to be engineered to withstand the operating conditions. With the global demand for energy increasing in the foreseeable future, the search for hydrocarbon resources is reaching into deeper and hotter wells. There is, therefore, a continuing and pressing need for high-temperature and high-coupling piezoelectric materials.

Radio frequency identification (RFID) in health care: privacy and security concerns limiting adoption.

PubMed

Rosenbaum, Benjamin P

2014-03-01

Radio frequency identification (RFID) technology has been implemented in a wide variety of industries. Health care is no exception. This article explores implementations and limitations of RFID in several health care domains: authentication, medication safety, patient tracking, and blood transfusion medicine. Each domain has seen increasing utilization of unique applications of RFID technology. Given the importance of protecting patient and data privacy, potential privacy and security concerns in each domain are discussed. Such concerns, some of which are inherent to existing RFID hardware and software technology, may limit ubiquitous adoption. In addition, an apparent lack of security standards within the RFID domain and specifically health care may also hinder the growth and utility of RFID within health care for the foreseeable future. Safeguarding the privacy of patient data may be the most important obstacle to overcome to allow the health care industry to take advantage of the numerous benefits RFID technology affords.

Data issues in the life sciences.

PubMed

Thessen, Anne E; Patterson, David J

2011-01-01

We review technical and sociological issues facing the Life Sciences as they transform into more data-centric disciplines - the "Big New Biology". Three major challenges are: 1) lack of comprehensive standards; 2) lack of incentives for individual scientists to share data; 3) lack of appropriate infrastructure and support. Technological advances with standards, bandwidth, distributed computing, exemplar successes, and a strong presence in the emerging world of Linked Open Data are sufficient to conclude that technical issues will be overcome in the foreseeable future. While motivated to have a shared open infrastructure and data pool, and pressured by funding agencies in move in this direction, the sociological issues determine progress. Major sociological issues include our lack of understanding of the heterogeneous data cultures within Life Sciences, and the impediments to progress include a lack of incentives to build appropriate infrastructures into projects and institutions or to encourage scientists to make data openly available.

Latin American algorithm for treatment of relapsing-remitting multiple sclerosis using disease-modifying agents.

PubMed

Finkelsztejn, Alessandro; Gabbai, Alberto Alain; Fragoso, Yara Dadalti; Carrá, Adriana; Macías-Islas, Miguel Angel; Arcega-Revilla, Raul; García-Bonitto, Juan; Oehninger-Gatti, Carlos Luis; Orozco-Escobar, Geraldine; Tarulla, Adriana; Vergara, Fernando; Vizcarra, Darwin

2012-10-01

It is estimated that circa 50,000 individuals have relapsing-remitting multiple sclerosis in Latin America. European and North-American algorithms for the treatment of multiple sclerosis do not foresee our regional difficulties and the access of patients to treatment. The Latin American Multiple Sclerosis Forum is an independent and supra-institutional group of experts that has assessed the latest scientific evidence regarding efficacy and safety of disease-modifying treatments. Accesses to treatment and pharmacovigilance programs for each of the eight countries represented at the Forum were also analyzed. A specific set of guidelines based upon evidence-based recommendations was designed for Latin America. Future perspectives of multiple sclerosis treatment were also discussed. The present paper translated an effort from representatives of eight countries discussing a matter that cannot be adapted to our region directly from purely European and North-American guidelines for treatment.

Novel bamboo structured TiO2 nanotubes for energy storage/production applications

NASA Astrophysics Data System (ADS)

Samuel, J. J.; Beh, K. P.; Cheong, Y. L.; Yusuf, W. A. A.; Yam, F. K.

2018-04-01

Nanostructured TiO2 received much attention owing to its high surface-to-volume ratio, which can be advantageous in energy storage and production applications. However, the increase in energy consumption at present and possibly the foreseeable future has demanded energy storage and production devices of even higher performance. A direct approach would be manipulating the physical aspects of TiO2 nanostructures, particularly, nanotubes. In this work, dual voltage anodization system has been implemented to fabricate bamboo shaped TiO2 nanotubes, which offers even greater surface area. This unique nanostructure would be used in Dye Sensitized Solar Cell (DSSC) fabrication and its performance will be evaluated and compared along other forms of TiO2 nanotubes. The results showed that bamboo shaped nanotubes indeed are superior morphologically, with an increase of efficiency of 107% at 1.130% efficiency when compared to smooth walled nanotubes at 0.546% efficiency.

Publication of the Korea-WHO Cooperation History - 70 Years of Working Together for Heath: World Health Organization and the Republic of Korea.

PubMed

Cho, Heeyeon; Lee, Dong Woo; Choe, Young June; Choe, Seung Ah; Park, No Yai

2017-03-01

The World Health Organization (WHO) have been in collaborative efforts with the Republic of Korea in keeping of and for better health for all for the past decades. From the control of parasites to building of community health system in rural places, the works has now resulted in healthier Korea than ever, and has transformed the role of engaging as the world leader in contribution of health and development. Seventy years of independence, war, and poverty, transforming from a recipient country of official development assistance to a significant donor to the global society, we have emphasized the importance of international cooperation and the role of WHO in the past years in Korea and neighboring countries. Looking back of the past is meaningful to diagnose the present problems, and to foresee the future of our world.

BiFeO3 Thin Films: A Playground for Exploring Electric-Field Control of Multifunctionalities

NASA Astrophysics Data System (ADS)

Yang, Jan-Chi; He, Qing; Yu, Pu; Chu, Ying-Hao

2015-07-01

A promising approach to the next generation of low-power, functional, and green nanoelectronics relies on advances in the electric-field control of lattice, charge, orbital, and spin degrees of freedom in novel materials. The possibility of electric-field control of these multiple materials functionalities offers interesting options across a range of modern technologies, including information communication, computing processes, data storage, active components, and functional electronics. This article reviews electric-field control and modulation of various degrees of freedom through the medium of multiferroic BiFeO3. Coexisting order parameters and inherent couplings in this materials system form a potent playground, enabling direct and indirect manipulation to obtain intriguing properties and functionalities with an electric stimulus. An in-depth understanding of those electrically controlled phenomena and breakthroughs is highlighted, paving a new route toward multifunctional nanoelectronics. This article concludes with a brief discussion on foreseeable challenges as well as future directions.

Water and Wastewater Rate Hikes Outpace CPI

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stratton, Hannah; Fuchs, Heidi; Chen, Yuting

Water and wastewater treatment and delivery is the most capital-intensive of all utility services. Historically underpriced, water and wastewater rates have exhibited unprecedented growth in the past fifteen years. Steep annual increases in water and wastewater rates that outpace the Consumer Price Index (CPI) have increasingly become the norm across the United States. In this paper, we analyze water and wastewater rates across U.S. census regions between 2000 and 2014. We also examine some of the driving factors behind these rate increases, including drought, water source, required infrastructure investment, population patterns, and conservation effects. Our results demonstrate that water andmore » wastewater prices have consistently increased and have outstripped CPI throughout the study period nationwide, as well as within each census region. Further, evaluation of the current and upcoming challenges facing water and wastewater utilities suggests that sharp rate increases are likely to continue in the foreseeable future.« less

Asteroid Impact Mission (aim) & Deflection Assessment: AN Opportunity to Understand Impact Dynamics and Modelling

NASA Astrophysics Data System (ADS)

Galvez, A.; Carnelli, I.; Fontaine, M.; Corral Van Damme, C.

2012-09-01

ESA's Future Preparation and Strategic Studies Office has carried out the Asteroid Impact Mission (AIM) study with the objective of defining an affordable and fully independent mission element that ESA could contribute to an Asteroid Impact Deflection Assessment campaign (AIDA), a joint effort of ESA, JHU/APL, NASA, OCA and DLR. The mission design foresees two independent spacecraft, one impactor (DART) and one rendezvous probe (AIM). The target of this mission is the binary asteroid system (65803) Didymos (1996 GT): one spacecraft, DART, would impact the secondary of the Didymos binary system while AIM would observe and measure any the change in the relative orbit. For this joint project, the timing of the experiment is set (maximum proximity of the target to Earth allowing for ground-based characterisation of the experiment) but the spacecraft are still able to pursue their missions fully independently. This paper describes in particular the AIM rendezvous mission concept.

Fine-Root Ecology Database (FRED): A Global Collection of Root Trait Data with Coincident Site, Vegetation, Edaphic, and Climatic Data, Version 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iversen, C. M.; Powell, A. S.; McCormack, M. L.

To address the need for a centralized root trait database, we are compiling the Fine-Root Ecology Database (FRED) from published literature and unpublished data. FRED Version 1 (FRED 1.0) currently houses more than 70,000 observations of root traits and their associated site, vegetation, edaphic, and climatic conditions from across the globe (see image below, which shows the more than 1000 distinct locations associated with observations in FRED 1.0). Data collection is ongoing and will continue for the foreseeable future. The more than 300 root traits currently housed in FRED 1.0 are described in detail here. FRED is focused on finemore » roots (less than 2 mm), as coarse roots are studied using different methodology, often at very different scales, and have different traits and trait interpretations.« less

Reduced Order Modeling of Combustion Instability in a Gas Turbine Model Combustor

NASA Astrophysics Data System (ADS)

Arnold-Medabalimi, Nicholas; Huang, Cheng; Duraisamy, Karthik

2017-11-01

Hydrocarbon fuel based propulsion systems are expected to remain relevant in aerospace vehicles for the foreseeable future. Design of these devices is complicated by combustion instabilities. The capability to model and predict these effects at reduced computational cost is a requirement for both design and control of these devices. This work focuses on computational studies on a dual swirl model gas turbine combustor in the context of reduced order model development. Full fidelity simulations are performed utilizing URANS and Hybrid RANS-LES with finite rate chemistry. Following this, data decomposition techniques are used to extract a reduced basis representation of the unsteady flow field. These bases are first used to identify sensor locations to guide experimental interrogations and controller feedback. Following this, initial results on developing a control-oriented reduced order model (ROM) will be presented. The capability of the ROM will be further assessed based on different operating conditions and geometric configurations.

Ethical reasons for narrowing the scope of biotech patents.

PubMed

Andreassen, Tom

2015-11-01

Patents on biotech products have a scope that goes well beyond what is covered by the most widely applied ethical justifications of intellectual property. Neither natural rights theory from Locke, nor public interest theory of IP rights justifies the wide scope of legal protection. The article takes human genes as an example, focusing on the component that is not invented but persists as unaltered gene information even in the synthetically produced complementary DNA, the cDNA. It is argued that patent on cDNA holds this information captive, or illegitimately appropriates it in limiting other researchers and inventors' opportunity to explore new functions and uses based on this non-invented information. A tighter connection between legal IP protection and the use description stated in the patent claim is suggested. By binding protection to the product's foreseeable functions and use, instead of the product itself and all future uses of it, legitimacy of biotech product patents is restored.

Leptospirosis in horses.

PubMed

Verma, Ashutosh; Stevenson, Brian; Adler, Ben

2013-11-29

Leptospirosis in horses has been considered a relatively uncommon infection. However, recent data suggest that the infection is widespread, with the incidence and infecting serovars varying considerably in different geographical regions. The majority of infections remain asymptomatic. Clinical signs in equine leptospirosis resemble those seen in other animal species. However, leptospirosis as a cause of acute respiratory distress is becoming more frequently recognised. A particular feature of equine leptospirosis is post infection recurrent uveitis (moon blindness or periodic ophthalmia), which appears to be mediated by autoimmune mechanisms involving cross reactivity between ocular tissues and leptospiral membrane proteins. There are no leptospiral vaccines licensed for use in horses, with no prospect for any becoming available in the foreseeable future. Accordingly, prevention of equine leptospirosis must rely on good hygiene practices, minimisation of rodent contact, and vaccination of other species of production and companion animals. Copyright © 2013 Elsevier B.V. All rights reserved.

The implications of Istanbul Declaration on organ trafficking and transplant tourism.

PubMed

Delmonico, Francis L

2009-04-01

Organ trafficking, transplant tourism and transplant commercialism are now defined by the Declaration of Istanbul; the Declaration provides principles of practice based on those definitions. Organ trafficking and transplant tourism should be prohibited because they violate the principles of equity, justice and respect for human dignity. This report provides a country-by-country description of current events that may effect the practice of transplantation internationally for the foreseeable future. The implications of the Istanbul Declaration are profound. It calls for a legal and professional framework in each country to govern organ donation and transplantation activities. It calls for a transparent regulatory oversight system that ensures donor and recipient safety and enforces the prohibitions of unethical practices. Governments should ensure the provision of care and follow-up of living donors be no less than the care and attention provided for transplants recipients.

Advances in thermoelectric materials research: Looking back and moving forward.

PubMed

He, Jian; Tritt, Terry M

2017-09-29

High-performance thermoelectric materials lie at the heart of thermoelectrics, the simplest technology applicable to direct thermal-to-electrical energy conversion. In its recent 60-year history, the field of thermoelectric materials research has stalled several times, but each time it was rejuvenated by new paradigms. This article reviews several potentially paradigm-changing mechanisms enabled by defects, size effects, critical phenomena, anharmonicity, and the spin degree of freedom. These mechanisms decouple the otherwise adversely interdependent physical quantities toward higher material performance. We also briefly discuss a number of promising materials, advanced material synthesis and preparation techniques, and new opportunities. The renewable energy landscape will be reshaped if the current trend in thermoelectric materials research is sustained into the foreseeable future. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Cerebrospinal Fluid Shunting Complications in Children

PubMed Central

Hanak, Brian W.; Bonow, Robert H.; Harris, Carolyn A.; Browd, Samuel R.

2018-01-01

Although cerebrospinal fluid (CSF) shunt placement is the most common procedure performed by pediatric neurosurgeons, shunts remain among the most failure-prone life-sustaining medical devices implanted in modern medical practice. This article provides an overview of the mechanisms of CSF shunt failure for the 3 most commonly employed definitive CSF shunts in the practice of pediatric neurosurgery: ventriculoperitoneal, ventriculopleural, and ventriculoatrial. The text has been partitioned into the broad modes of shunt failure: obstruction, infection, mechanical shunt failure, overdrainage, and distal catheter site-specific failures. Clinical management strategies for the various modes of shunt failure are discussed as are research efforts directed towards reducing shunt complication rates. As it is unlikely that CSF shunting will become an obsolete procedure in the foreseeable future, it is incumbent on the pediatric neurosurgery community to maintain focused efforts to improve our understanding of and management strategies for shunt failure and shunt-related morbidity. PMID:28249297

Necessary conditions for the globalization of traditional Chinese medicine.

PubMed

Yu, Bei-Bei; Gong, Xiu-Lin

2011-03-01

With the current trend of globalization, unprecedented opportunities and enormous changes have emerged for the global development of traditional Chinese medicine (TCM). However, many old and new challenges and problems still remain, including partial or limited comprehension of acupuncture, oriental medicine and TCM, the existence of non-standardized institutes of TCM and acupuncture training schools, unqualified TCM practitioners, and problems concerning Chinese herbal medicine and inexperience in conducting TCM business. These problems will doubtlessly impede the further development of TCM worldwide in the foreseeable future. It is also clear that the globalization of TCM will require a large scale systematic project and constitute an arduous historical task. This paper aims to consolidate 6 strategic development modes to reinforce and facilitate the process of TCM globalization through a detailed analysis of both the present status and existing problems concerning the development of TCM in the United States.

Ultra-cool dwarfs viewed equator-on: surveying the best host stars for biosignature detection in transiting exoplanets

NASA Astrophysics Data System (ADS)

Miles-Paez, Paulo; Metchev, Stanimir; Burgasser, Adam; Apai, Daniel; Palle, Enric; Zapatero Osorio, Maria Rosa; Artigau, Etienne; Mace, Greg; Tannock, Megan; Triaud, Amaury

2018-05-01

There are about 150 known planets around M dwarfs, but only one system around an ultra-cool (>M7) dwarf: Trappist-1. Ultra-cool dwarfs are arguably the most promising hosts for atmospheric and biosignature detection in transiting planets because of the enhanced feature contrast in transit and eclipse spectroscopy. We propose a Spitzer survey to continuously monitor 15 of the brightest ultra-cool dwarfs over 3 days. To maximize the probability of detecting transiting planets, we have selected only targets seen close to equator-on. Spin-orbit alignment expectations dictate that the planetary systems around these ultra-cool dwarfs should also be oriented nearly edge-on. Any planet detections from this survey will immediately become top priority targets for JWST transit spectroscopy. No other telescope, present or within the foreseeable future, will be able to conduct a similarly sensitive and dedicated survey for characterizeable Earth analogs.

Improving GOCE cross-track gravity gradients

NASA Astrophysics Data System (ADS)

Siemes, Christian

2018-01-01

The GOCE gravity gradiometer measured highly accurate gravity gradients along the orbit during GOCE's mission lifetime from March 17, 2009, to November 11, 2013. These measurements contain unique information on the gravity field at a spatial resolution of 80 km half wavelength, which is not provided to the same accuracy level by any other satellite mission now and in the foreseeable future. Unfortunately, the gravity gradient in cross-track direction is heavily perturbed in the regions around the geomagnetic poles. We show in this paper that the perturbing effect can be modeled accurately as a quadratic function of the non-gravitational acceleration of the satellite in cross-track direction. Most importantly, we can remove the perturbation from the cross-track gravity gradient to a great extent, which significantly improves the accuracy of the latter and offers opportunities for better scientific exploitation of the GOCE gravity gradient data set.

Data issues in the life sciences

PubMed Central

Thessen, Anne E.; Patterson, David J.

2011-01-01

Abstract We review technical and sociological issues facing the Life Sciences as they transform into more data-centric disciplines - the “Big New Biology”. Three major challenges are: 1) lack of comprehensive standards; 2) lack of incentives for individual scientists to share data; 3) lack of appropriate infrastructure and support. Technological advances with standards, bandwidth, distributed computing, exemplar successes, and a strong presence in the emerging world of Linked Open Data are sufficient to conclude that technical issues will be overcome in the foreseeable future. While motivated to have a shared open infrastructure and data pool, and pressured by funding agencies in move in this direction, the sociological issues determine progress. Major sociological issues include our lack of understanding of the heterogeneous data cultures within Life Sciences, and the impediments to progress include a lack of incentives to build appropriate infrastructures into projects and institutions or to encourage scientists to make data openly available. PMID:22207805

“Bare Branches” and the Marriage Market in Rural China: Preliminary Evidence from a village-level survey1

PubMed Central

Jin, Xiaoyi; Liu, Lige; Li, Yan; Feldman, Marcus W.; Li, Shuzhuo

2015-01-01

Using data from a village survey in rural China, this study explores the relationships between current prevalence of involuntary bachelorhood and its causes and social consequences at the village level. We find that bachelors, inter-county marriage and marriage fraud exist in all regions, and are expected to become more frequent with the increasing surplus of males born after 1980 entering the marriage market. The marriage squeeze and social problems related to the bachelors are more serious in less-developed western villages, and heterogeneity within central villages is significant. Economic and socio-demographic factors are shown to be the major causes of the prevalence of bachelors at the village level in contemporary rural China. Our findings confirm the negative consequences of the marriage squeeze, and effective policies are urgently needed to respond to and prevent more negative consequences of gender imbalance in the foreseeable future. PMID:26213641

Solar Neutrinos

DOE R&D Accomplishments Database

Davis, R. Jr.; Harmer, D. S.

1964-12-01

The prospect of studying the solar energy generation process directly by observing the solar neutrino radiation has been discussed for many years. The main difficulty with this approach is that the sun emits predominantly low energy neutrinos, and detectors for observing low fluxes of low energy neutrinos have not been developed. However, experimental techniques have been developed for observing neutrinos, and one can foresee that in the near future these techniques will be improved sufficiently in sensitivity to observe solar neutrinos. At the present several experiments are being designed and hopefully will be operating in the next year or so. We will discuss an experiment based upon a neutrino capture reaction that is the inverse of the electron-capture radioactive decay of argon-37. The method depends upon exposing a large volume of a chlorine compound, removing the radioactive argon-37 and observing the characteristic decay in a small low-level counter.

Food security and cardioprotection: the polar lipid link.

PubMed

Zabetakis, Ioannis

2013-08-01

The projected increase in world population and therefore demand for food in the foreseeable future pose some risks on how secure is the food production system today. Millions of people are threatened by malnutrition, cardiovascular diseases (CVDs), diabetes, and obesity. This is a multidimensional challenge: the production of food needs to be increased but also the quality of food needs to be improved so less people suffer from undernourishment and CVDs. This hypothesis paper addresses this problem by critically evaluating recent developments on the role of food components against CVDs, presenting recent insights for assessing the nutritional value of food and suggesting novel approaches toward the sustainable production of food that would, in turn, lead to increased food security. The issue of the sustainability of lipid sources and genetically modified crops is also discussed from a food security point of view. © 2013 Institute of Food Technologists®

Optometry in Portugal: a historical perspective

NASA Astrophysics Data System (ADS)

Teixeira, Eduardo; Baptista, António M. G.; Sousa, Raul A. R. C.

2011-05-01

The establishment and development of optometry in Portugal resulted from the committed work of many individuals and institutions. These efforts have had good results in terms of raising the public's awareness of the major role played by optometrists in primary eye care. Back in the late 80's higher education in optometry was started. Ten years ago the results of scientific research on the topic first became available and are now also contributing to the success of optometry in Portugal. In regard to the optometry profession, specific regulations are to be discussed in the national parliament. The Associação de Profissionais Licenciados de Optometria (APLO), as the professional organization representing optometrists in Portugal, has been critically important in this process. This article will present an overview of the history of optometry in Portugal, of change in the foreseeable future and of the APLO's experience and activities.

Drop-casted self-assembling graphene oxide membranes for scanning electron microscopy on wet and dense gaseous samples.

PubMed

Krueger, Mark; Berg, Shannon; Stone, D'Arcy; Strelcov, Evgheni; Dikin, Dmitriy A; Kim, Jaemyung; Cote, Laura J; Huang, Jiaxing; Kolmakov, Andrei

2011-12-27

Graphene oxide sheets dispersed in water and many other solvents can spontaneously assemble into a surface film covering an evaporating droplet due to their amphiphilicity. Thus, graphene oxide membranes with controllable thickness suspended over an orifice have been directly fabricated using a simple drop-cast approach. Mechanical properties and electron transparency tests of these membranes show their use as electron transparent, but molecularly impenetrable, windows for environmental electron microscopy in liquids and dense gaseous media. The foreseeable, broader application of this drop-cast window methodology is the creation of access spots for electron probes to study isolated microsamples in their natural, undisrupted state within the interior of prefabricated devices (such as microfluidic chips or sealed containers of biological, chemically reactive, toxic, or forensic materials).

Arco foresees productivity increases with AI technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smutz, J.

1989-01-09

Efforts are under way in exploration, production, and drilling to exploit the powerful technology known as artificial intelligence (AI). Arco Oil and Gas Co. (AOGC) foresees AI increasing productivity in nearly every aspect of its business. The industry trend toward applying state-of-the-art technology to exploration and production applications is creating a definite realignment of resources within AOGC information services. AI technologies such as expert systems represent a powerful, yet complex opportunity. The learning curve with which AI technologies challenge us can be effectively addressed through progressive hands-on experience. By beginning where cost effectiveness can be easily demonstrated and evolving tomore » more ambitious projects, this new way of thinking about applications can be effectively assimilated.« less

Trauma and the state with Sigmund Freud as witness.

PubMed

Danto, Elizabeth Ann

Just before and after the end of World War I, Sigmund Freud took on an activist role and in his writings and speeches, redirected the concept of war trauma from individual failure to a larger issue of community responsibility. Testifying in Vienna as an expert witness for the state, Freud said that the military psychiatrists-not the soldiers-had "acted like machine guns behind the front" and were the "immediate cause of all war neurosis." Freud was called on by the legal community when Julius Wagner-Jauregg, a future Nobel Prize winner (and also future Nazi Party adherent), head of the municipal Clinic for Psychiatry and Nervous Diseases, was accused of the lethal use of electrotherapy on shell-shocked soldiers. As sociological as psychoanalytic in his responses, Freud's withering critique came just 2years after he avowed that "it is possible to foresee that the conscience of society will awake." That speech on the human right to mental health care affirmed Freud's alliance to the social democratic position and inspired the second generation of psychoanalysts to develop community-based clinics throughout Europe where treatment was free of cost, for war neurosis and beyond. Copyright © 2016 Elsevier Ltd. All rights reserved.

Plant genetics, sustainable agriculture and global food security.

PubMed

Ronald, Pamela

2011-05-01

The United States and the world face serious societal challenges in the areas of food, environment, energy, and health. Historically, advances in plant genetics have provided new knowledge and technologies needed to address these challenges. Plant genetics remains a key component of global food security, peace, and prosperity for the foreseeable future. Millions of lives depend upon the extent to which crop genetic improvement can keep pace with the growing global population, changing climate, and shrinking environmental resources. While there is still much to be learned about the biology of plant-environment interactions, the fundamental technologies of plant genetic improvement, including crop genetic engineering, are in place, and are expected to play crucial roles in meeting the chronic demands of global food security. However, genetically improved seed is only part of the solution. Such seed must be integrated into ecologically based farming systems and evaluated in light of their environmental, economic, and social impacts-the three pillars of sustainable agriculture. In this review, I describe some lessons learned, over the last decade, of how genetically engineered crops have been integrated into agricultural practices around the world and discuss their current and future contribution to sustainable agricultural systems.

Environmental regulation of sex determination in oil palm: current knowledge and insights from other species.

PubMed

Adam, Hélène; Collin, Myriam; Richaud, Frédérique; Beulé, Thierry; Cros, David; Omoré, Alphonse; Nodichao, Leifi; Nouy, Bruno; Tregear, James W

2011-12-01

The African oil palm (Elaeis guineensis) is a monoecious species of the palm subfamily Arecoideae. It may be qualified as 'temporally dioecious' in that it produces functionally unisexual male and female inflorescences in an alternating cycle on the same plant, resulting in an allogamous mode of reproduction. The 'sex ratio' of an oil palm stand is influenced by both genetic and environmental factors. In particular, the enhancement of male inflorescence production in response to water stress has been well documented. This paper presents a review of our current understanding of the sex determination process in oil palm and discusses possible insights that can be gained from other species. Although some informative phenological studies have been carried out, nothing is as yet known about the genetic basis of sex determination in oil palm, nor the mechanisms by which this process is regulated. Nevertheless new genomics-based techniques, when combined with field studies and biochemical and molecular cytological-based approaches, should provide a new understanding of the complex processes governing oil palm sex determination in the foreseeable future. Current hypotheses and strategies for future research are discussed.

Commentary: expectations for global health program prioritization from a selection of international students studying at a European university.

PubMed

Quinn, John; Lidinský, Vít; Rajaratnam, Venu; Kruszcynski, Marta; Zeleny, Tomas; Bencko, Vladimir

2016-09-22

Some university curricula struggle to present evidence-based promotion of global health principles and global health diplomacy within an undergraduate setting. The de facto global health paradigm has experienced significant stress and pressure from epidemics, war and violence, climate change and resource challenges. These stressors may lead to increased morbidity and mortality, in turn requiring medical professionals to play a larger role in global health action across borders. In the academic year 2014-2015, an English-speaking international medical school promoted a global health forum with pre-course readings and a pre-attendance quiz. All students from the university were invited to attend and the event was not mandatory. The one-day-event culminated in expert speakers, discussions and a post-event questionnaire to gauge students' reactions and expectations as future physicians regarding the most pressing global health topics. Emphasis was also placed on what future doctors foresee as pressing issues in forthcoming global health policy and programming. This paper is a brief commentary of the Global Health Forum in Prague 2014, and presents novel results from a post-event student questionnaire, with conclusions provided by students on innovative global health policy.

Geriatric Cardiology: An Emerging Discipline.

PubMed

Dodson, John A; Matlock, Daniel D; Forman, Daniel E

2016-09-01

Given changing demographics, patients with cardiovascular (CV) disease in developed countries are now older and more complex than even a decade ago. This trend is expected to continue into the foreseeable future; accordingly, cardiologists are encountering patients with a greater number of comorbid illnesses as well as "geriatric conditions," such as cognitive impairment and frailty, which complicate management and influence outcomes. Simultaneously, technological advances have widened the therapeutic options available for patients, including those with the most advanced CV disease. In the setting of these changes, geriatric cardiology has recently emerged as a discipline that aims to adapt principles from geriatric medicine to everyday cardiology practice. Accordingly, the tasks of a "geriatric cardiologist" may include both traditional evidence-based CV management plus comprehensive geriatric assessment, medication reduction, team-based coordination of care, and explicit incorporation of patient goals into management. Given that the field is still in its relative infancy, the training pathways and structure of clinical programs in geriatric cardiology are still being delineated. In this review, we highlight the rationale behind geriatric cardiology as a discipline, several current approaches by geriatric cardiology programs, and future directions for the field. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

Kidney transplantation in emerging countries: do we know all issues?

PubMed

Spasovski, G; Vanholder, R

2012-09-01

Although it seems that end stage renal disease (ESRD) therapies gradually become more accessible in the developing world, yet, the vast majority of people living in those areas do not have access to dialysis and especially transplantation because of the economic and technological inequality as compared with the developed world. Despite the great advantage in survival and considerable socioeconomic advantages of transplantation vs. dialysis, there is a widespread recognition that the growing gap between organ supply and demand will continue into the foreseeable future. Several reasons might be considered in this regard as: insufficient data on the topic in the public domain, inadequate governmental financial resources, lack of public awareness, education and motivation for organ donation as well as the low number of organized teams of transplant surgeons and nephrologists, and lack of organizational infrastructure, i.e. coordinators. The defined priorities for the future in terms of improving living donor transplantation, composition of the official waiting lists and registries of transplant recipients and living donors and the role of transplant professionals have been discussed. In conclusion, whatever the governmental support is, as professionals, we should just reinforce our efforts to help our patients as best as we can in the current situation.

Nuclear power grows in China`s energy mix

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Xavier

1996-07-01

China`s rapid economic growth in the past two decades has caused the nations`s demand for electricity to exceed its capacity. AS of 1992, with power shortages as high as 25 percent, {open_quotes}power plant operators were often forced to resort to rolling brownouts to avoid complete system breakdowns,{close_quotes} says Xavier Chen, an assistant professor with the Asian Institute of Technology`s Energy Program in Bangkok, Thailand. To keep pace with China`s economic development, Chen estimates that {open_quotes}China must increase its electricity capacity 6 to 8 percent a year each year into the foreseeable future.{close_quotes} For now, coal is transported to power plantsmore » in the rapidly developing eastern coastal provinces at great expense. Chen also notes that the environmental disadvantages of coal make it a less desirable source of energy than nuclear. Development of nuclear energy is likely to go forward for another reason: In China, there is much less opposition to nuclear power plants than in other developing nations. {open_quotes}Nuclear energy likely will plan an important role in China`s future energy mix and help close the gap between electricity production and demand,{close_quotes} Chen says.« less

Green and sustainable City will become the development objective of China’s Low Carbon City in future

PubMed Central

2014-01-01

Environmental pollution and greenhouse gas emissions are becoming significant environmental issues in China, thus the sustainable development and revival of the country is impossible using the conventional path of encouraging economic growth at the expense of the environment. In response to the global warming, the prices of the traditional energy rise considerably, and a series of environmental problems, China must improve its own mode of economic development. Hundreds of Chinese cities have billions of square meters of buildings and most industry and the annual energy demand is an astronomical figure. China’s government is facing increasing pressure in the low carbon international backdrop, and the low carbon city becomes the inevitable developmental direction of Chinese city in the foreseeable future. The description is first centered on energy structure/energy consumption per unit/urbanized status, and urban energy consumption status, and then concerned with the efforts and measures of Chinese government, to realize the energy saving. Finally, we present the developmental prospect and barriers and the promotion measures related to the low carbon city under the government policy, financial incentives and funding supports, etc. PMID:24423063

Geriatric Cardiology: An Emerging Discipline

PubMed Central

Dodson, John A.; Matlock, Daniel D.; Forman, Daniel E.

2017-01-01

Given changing demographics, patients with cardiovascular (CV) disease in developed countries are now older and more complex than even a decade ago. This trend is expected to continue into the foreseeable future; accordingly, cardiologists in practice are encountering patients with a greater number of comorbid illnesses as well as “geriatric conditions” such as cognitive impairment and frailty which complicate management and influence outcomes. Simultaneously, technological advances have widened the therapeutic options available for patients, including those with the most advanced CV disease. In the setting of these changes, geriatric cardiology has recently emerged as a discipline that aims to adapt principles from geriatric medicine into everyday cardiology practice. Accordingly, the tasks of a “geriatric cardiologist” may include both traditional evidence-based CV management plus comprehensive geriatric assessment, medication reduction, team-based coordination of care, and explicit incorporation of patient goals into management. Given that the field is still in its relative infancy, the training pathways and structure of clinical programs in geriatric cardiology are still being delineated. In this review we highlight the rationale behind geriatric cardiology as a discipline, several current approaches by geriatric cardiology programs, and future directions for the field. PMID:27476988

History of Romanian Medical Informatics: Learning from the Past to Reshape the Future.

PubMed

Mihalas, George I; Stoicu-Tivadar, Lacramioara

2018-04-22

 The paper presents a review of the history of medical informatics in Romania, starting from the pioneering works, relating the present, and foreseeing the future.  Major milestones of the development of this field have not been simply enumerated, but described within the specific socio-political frame, grasping the entire context over the last four decades in Romania. Two main perspectives have been traced: education and training in medical informatics and implementations in healthcare.  Four distinctive historical periods are identified and the major events of each period are described in a critical manner. The history of the Romanian Society of Medical Informatics is presented in a separate chapter. The last section is dedicated to the present state of the field in Romania.  The history of Romanian Medical Informatics spans many years and is rich in content. The Romanian Society of Medical Informatics is mainly the result of the efforts undertaken by an enthusiastic and sound professional community, trying to continue the tradition, to achieve new goals, and to work as an active member of the international biomedical/health informatics community. Georg Thieme Verlag KG Stuttgart.

An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".

PubMed

Hartung, Thomas; Blaauboer, Bas J; Bosgra, Sieto; Carney, Edward; Coenen, Joachim; Conolly, Rory B; Corsini, Emanuela; Green, Sidney; Faustman, Elaine M; Gaspari, Anthony; Hayashi, Makoto; Wallace Hayes, A; Hengstler, Jan G; Knudsen, Lisbeth E; Knudsen, Thomas B; McKim, James M; Pfaller, Walter; Roggen, Erwin L

2011-01-01

The European cosmetics legislation foresees a review in 2011 and possible postponement of the 2013 marketing ban to enforce the testing ban for systemic and repeated-dose animal tests. For this purpose, a 119-page report commissioned by the European Commission was published recently. Here, a group of 17 independent experts from the US, Europe, and Japan was brought together to evaluate the report. The expert panel strongly endorsed the report and its conclusions. A number of important options not considered were identified; these do not, however, affect the overall conclusions regarding the current lack of availability of a full replacement, especially for the areas of repeated dose toxicity, carcinogenicity testing, and reproductive toxicity, though a roadmap for change is emerging. However, some of these options may provide adequate data for replacement of some animal studies in the near future pending validation. Various recommendations expand the original report. The reviewers agree with the report that there is greater promise in the short term for the areas of sensitization and toxicokinetics. Additional opportunities lie in more global collaborations and the inclusion of other industry sectors.

Retrospective and prospective analysis of water use and point source pollution from an economic perspective-a case study of Urumqi, China.

PubMed

Wang, Bing; Liu, Lei; Huang, Guohe

2017-11-01

Using the Environmental Kuznets Curve (EKC) hypothesis, this study explored the dynamic trends of water use and point source pollution in Urumqi (2000-2014) from an economic perspective. Retrospective analysis results indicated that total GDP and GDP per capita increased around tenfold and a fivefold since 2000. Total, municipal and industrial water use had average annual growth rates of 3.96, 7.01, and 3.69%, respectively. However, agricultural water use, emissions of COD and NH 3 -N showed average annual decreases of 3.06, 12.40, and 4.74%. Regression models reveal that total water demand in Urumqi would keep monotonically increasing relationships with GDP and GDP per capita in the foreseeable years. However, the relations of specific water usage and economic growth showed diverse trends. In the future, the discharge of COD and NH 3 -N would further reduce with economic growth. It could be concluded that Urumqi has almost passed the stage where economic growth had caused serious environment deterioration, but the increasing water demand in Urumqi is still an urgent problem. The obtained results would be helpful for water resources management and pollution control in the future.

Map showing the potential for mineral deposits associated with Precambrian mafic and ultramafic rocks in the Blacktail and Henrys Lake mountains and the Greenhorn and Ruby ranges of southwestern Montana

USGS Publications Warehouse

Hammarstrom, Jane M.; Van Gosen, Bradley S.; Carlson, Robert R.; Kulik, Dolores M.

1998-01-01

In response to requests from the Bureau of Land Management (BLM) and the U.S. Forest Service (USFS), the U.S. Geological Survey (USGS) conducted a mineral resource assessment in the Dillon BLM Resource Area in Beaverhead and Madison Counties, southwestern Montana. These agencies use mineral resource data in creating and updating land-use management plans for federal lands for the reasonably foreseeable future. Mineral resources that have not been developed in the past may be developed in the future, based on changing commodity demands and market conditions. Therefore, federal land managers need geologic information on known mineral occurrences as well as on areas that are permissive for the occurrence of undiscovered mineral resources. This map was prepared to provide this type of geologic information for mineral deposits that can be associated with ultramafic rocks. Areas of exposed Precambrian ultramafic rocks are labeled with uppercase letters (A-F). Sources of geologic maps used to compile this map are shown on the smaller index map ("Index to Geologic Mapping"); lowercase letters (a-m) on the index map are keyed to the reference list.

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges

PubMed Central

Alayed, Mrwan

2017-01-01

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system. PMID:28906462

Nuclear energy and health: and the benefits of low-dose radiation hormesis.

PubMed

Cuttler, Jerry M; Pollycove, Myron

2009-01-01

Energy needs worldwide are expected to increase for the foreseeable future, but fuel supplies are limited. Nuclear reactors could supply much of the energy demand in a safe, sustainable manner were it not for fear of potential releases of radioactivity. Such releases would likely deliver a low dose or dose rate of radiation, within the range of naturally occurring radiation, to which life is already accustomed. The key areas of concern are discussed. Studies of actual health effects, especially thyroid cancers, following exposures are assessed. Radiation hormesis is explained, pointing out that beneficial effects are expected following a low dose or dose rate because protective responses against stresses are stimulated. The notions that no amount of radiation is small enough to be harmless and that a nuclear accident could kill hundreds of thousands are challenged in light of experience: more than a century with radiation and six decades with reactors. If nuclear energy is to play a significant role in meeting future needs, regulatory authorities must examine the scientific evidence and communicate the real health effects of nuclear radiation. Negative images and implications of health risks derived by unscientific extrapolations of harmful effects of high doses must be dispelled.

Nuclear Energy and Health: And the Benefits of Low-Dose Radiation Hormesis

PubMed Central

Cuttler, Jerry M.; Pollycove, Myron

2009-01-01

Energy needs worldwide are expected to increase for the foreseeable future, but fuel supplies are limited. Nuclear reactors could supply much of the energy demand in a safe, sustainable manner were it not for fear of potential releases of radioactivity. Such releases would likely deliver a low dose or dose rate of radiation, within the range of naturally occurring radiation, to which life is already accustomed. The key areas of concern are discussed. Studies of actual health effects, especially thyroid cancers, following exposures are assessed. Radiation hormesis is explained, pointing out that beneficial effects are expected following a low dose or dose rate because protective responses against stresses are stimulated. The notions that no amount of radiation is small enough to be harmless and that a nuclear accident could kill hundreds of thousands are challenged in light of experience: more than a century with radiation and six decades with reactors. If nuclear energy is to play a significant role in meeting future needs, regulatory authorities must examine the scientific evidence and communicate the real health effects of nuclear radiation. Negative images and implications of health risks derived by unscientific extrapolations of harmful effects of high doses must be dispelled. PMID:19343116

A review on digital ECG formats and the relationships between them.

PubMed

Trigo, Jesús Daniel; Alesanco, Alvaro; Martínez, Ignacio; García, José

2012-05-01

A plethora of digital ECG formats have been proposed and implemented. This heterogeneity hinders the design and development of interoperable systems and entails critical integration issues for the healthcare information systems. This paper aims at performing a comprehensive overview on the current state of affairs of the interoperable exchange of digital ECG signals. This includes 1) a review on existing digital ECG formats, 2) a collection of applications and cardiology settings using such formats, 3) a compilation of the relationships between such formats, and 4) a reflection on the current situation and foreseeable future of the interoperable exchange of digital ECG signals. The objectives have been approached by completing and updating previous reviews on the topic through appropriate database mining. 39 digital ECG formats, 56 applications, tools or implantation experiences, 47 mappings/converters, and 6 relationships between such formats have been found in the literature. The creation and generalization of a single standardized ECG format is a desirable goal. However, this unification requires political commitment and international cooperation among different standardization bodies. Ongoing ontology-based approaches covering ECG domain have recently emerged as a promising alternative for reaching fully fledged ECG interoperability in the near future.

The Tissue-Engineered Vascular Graft—Past, Present, and Future

PubMed Central

Pashneh-Tala, Samand; MacNeil, Sheila

2016-01-01

Cardiovascular disease is the leading cause of death worldwide, with this trend predicted to continue for the foreseeable future. Common disorders are associated with the stenosis or occlusion of blood vessels. The preferred treatment for the long-term revascularization of occluded vessels is surgery utilizing vascular grafts, such as coronary artery bypass grafting and peripheral artery bypass grafting. Currently, autologous vessels such as the saphenous vein and internal thoracic artery represent the gold standard grafts for small-diameter vessels (<6 mm), outperforming synthetic alternatives. However, these vessels are of limited availability, require invasive harvest, and are often unsuitable for use. To address this, the development of a tissue-engineered vascular graft (TEVG) has been rigorously pursued. This article reviews the current state of the art of TEVGs. The various approaches being explored to generate TEVGs are described, including scaffold-based methods (using synthetic and natural polymers), the use of decellularized natural matrices, and tissue self-assembly processes, with the results of various in vivo studies, including clinical trials, highlighted. A discussion of the key areas for further investigation, including graft cell source, mechanical properties, hemodynamics, integration, and assessment in animal models, is then presented. PMID:26447530

Winter electricity supply and seasonal storage deficit in the Swiss Alps

NASA Astrophysics Data System (ADS)

Manso, Pedro; Monay, Blaise; Dujardin, Jérôme; Schaefli, Bettina; Schleiss, Anton

2017-04-01

Switzerland electricity production depends at 60% on hydropower, most of the remainder coming from nuclear power plants. The ongoing energy transition foresees an increase in renewable electricity production of solar photovoltaic, wind and geothermal origin to replace part of nuclear production; hydropower, in its several forms, will continue to provide the backbone and the guarantee of the instantaneous and permanent stability of the electric system. One of the key elements of any future portfolio of electricity mix with higher shares of intermittent energy sources like wind and solar are fast energy storage and energy deployment solutions. Hydropower schemes with pumping capabilities are eligible for storage at different time scales, whereas high-head storage hydropower schemes have already a cornerstone role in today's grid operation. These hydropower storage schemes have also been doing what can be labelled as "seasonal energy storage" in different extents, storing abundant flows in the wet season (summer) to produce electricity in the dry (winter) alpine season. Some of the existing reservoirs are however under sized with regards to the available water inflows and either spill over or operate as "run-of-the-river" which is economically suboptimal. Their role in seasonal energy transfer could increase through storage capacity increase (by dam heightening, by new storage dams in the same catchment). Inversely, other reservoirs that already store most of the wet season inflow might not fill up in the future in case inflows decrease due to climate changes; these reservoirs might then have extra storage capacity available to store energy from sources like solar and wind, if water pumping capacity is added or increased. The present work presents a comprehensive methodology for the identification of the seasonal storage deficit per catchment considering todays and future hydrological conditions with climate change, applied to several landmark case studies in Switzerland. In some cases additional storage would allow mitigating negative impacts of climate change. In one of the tested cases the decrease in inflows is such that the reservoir will not fill up in the future; this reservoir will become a priority location for pumping capacity increase, for short-term or seasonal storage of excess solar/wind energy. Considering that the present average rate of glacier mass loss at the country scale is equivalent to the Grande Dixence reservoir per year (the largest Swiss reservoir, approx. 380 hm3), increasing artificial water storage might become mandatory to maintain the same level of security electricity supply in the future.

Overview of past, present and future marine power plants

NASA Astrophysics Data System (ADS)

Morsy El-Gohary, M.

2013-06-01

In efforts to overcome an foreseeable energy crisis predicated on limited oil and gas supplies, reserves; economic variations facing the world, and of course the environmental side effects of fossil fuels, an urgent need for energy sources that provide sustainable, safe and economic supplies for the world is imperative. The current fossil fuel energy system must be improved to ensure a better and cleaner transportation future for the world. Despite the fact that the marine transportation sector consumes only 5% of global petroleum production; it is responsible for 15% of the world NO x and SO x emissions. These figures must be the engine that powers the scientific research worldwide to develop new solutions for a very old energy problem. In this paper, the most effective types of marine power plants were discussed. The history of the development of each type was presented first and the technical aspects were discussed second. Also, the fuel cells as a new type of power plants used in marine sector were briefed to give a complete overview of the past, present and future of the marine power plants development. Based on the increased worldwide concerns regarding harmful emissions, many researchers have introduced solutions to this problem, including the adoption of new cleaner fuels. This paper was guided using the same trend and by implementing the hydrogen as fuel for marine internal combustion engine, gas turbines, and fuel cells.

18 CFR 806.23 - Standards for water withdrawals.

Code of Federal Regulations, 2013 CFR

2013-04-01

... of groundwater or stream flow levels; rendering competing supplies unreliable; affecting other water... reasonably foreseeable water needs from available groundwater or surface water without limitation: (i...

18 CFR 806.23 - Standards for water withdrawals.

Code of Federal Regulations, 2014 CFR

2014-04-01

... of groundwater or stream flow levels; rendering competing supplies unreliable; affecting other water... reasonably foreseeable water needs from available groundwater or surface water without limitation: (i...

18 CFR 806.23 - Standards for water withdrawals.

Code of Federal Regulations, 2012 CFR

2012-04-01

... of groundwater or stream flow levels; rendering competing supplies unreliable; affecting other water... reasonably foreseeable water needs from available groundwater or surface water without limitation: (i...

16 CFR 1305.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... foreseeable use. (d) Emberizing materials means an asbestos-containing material generally packed in an... by flames are not included in this definition. Electric artificial logs and artificial ash beds used...

A quantitative assessment of the contributions of climatic indicators to changes in nutrients and oxygen levels in a shallow reservoir in China

NASA Astrophysics Data System (ADS)

Zhang, Chen; Zhang, Wenna; Liu, Hanan; Gao, Xueping; Huang, Yixuan

2017-06-01

Climate change has an indirect effect on water quality in freshwater ecosystems, but it is difficult to assess the contribution of climate change to the complex system. This study explored to what extent climatic indicators (air temperature, wind speed, and rainfall) influence nutrients and oxygen levels in a shallow reservoir, Yuqiao Reservoir, China. The study comprises three parts—describing the temporal trends of climatic indicators and water quality parameters during the period 1992-2011, analyzing the potential impacts of climate on water quality, and finally developing a quantitative assessment to evaluate how climatic factors govern nutrient levels in the reservoir. Our analyses showed that the reservoir experienced substantial cold periods (1992-2001) followed by a warm period (2002-2011). The results showed that increasing air temperature in spring, autumn, and winter and increasing annual wind speed decrease total phosphorus (TP) concentration in the reservoir in spring, summer, and winter. According to the quantitative assessment, the increase in air temperature in spring and winter had a larger contribution to the decrease in TP concentration (47.2 and 64.1%), compared with the influence from decreased wind speed and rainfall. The field data suggest that nutrients decline due to enhanced uptake by macrophytes in years when spring was warmer and the macrophytes started to grow earlier in the season. The increasing wind speed and air temperature in spring also significantly contribute to the increase in dissolved oxygen concentration. This study helps managers to foresee how potential future climate change might influence water quality in similar lake ecosystems.

Sustainable fuel for the transportation sector

PubMed Central

Agrawal, Rakesh; Singh, Navneet R.; Ribeiro, Fabio H.; Delgass, W. Nicholas

2007-01-01

A hybrid hydrogen-carbon (H2CAR) process for the production of liquid hydrocarbon fuels is proposed wherein biomass is the carbon source and hydrogen is supplied from carbon-free energy. To implement this concept, a process has been designed to co-feed a biomass gasifier with H2 and CO2 recycled from the H2-CO to liquid conversion reactor. Modeling of this biomass to liquids process has identified several major advantages of the H2CAR process. (i) The land area needed to grow the biomass is <40% of that needed by other routes that solely use biomass to support the entire transportation sector. (ii) Whereas the literature estimates known processes to be able to produce ≈30% of the United States transportation fuel from the annual biomass of 1.366 billion tons, the H2CAR process shows the potential to supply the entire United States transportation sector from that quantity of biomass. (iii) The synthesized liquid provides H2 storage in an open loop system. (iv) Reduction to practice of the H2CAR route has the potential to provide the transportation sector for the foreseeable future, using the existing infrastructure. The rationale of using H2 in the H2CAR process is explained by the significantly higher annualized average solar energy conversion efficiency for hydrogen generation versus that for biomass growth. For coal to liquids, the advantage of H2CAR is that there is no additional CO2 release to the atmosphere due to the replacement of petroleum with coal, thus eliminating the need to sequester CO2. PMID:17360377

Practical comparison of distributed ledger technologies for IoT

NASA Astrophysics Data System (ADS)

Red, Val A.

2017-05-01

Existing distributed ledger implementations - specifically, several blockchain implementations - embody a cacophony of divergent capabilities augmenting innovations of cryptographic hashes, consensus mechanisms, and asymmetric cryptography in a wide variety of applications. Whether specifically designed for cryptocurrency or otherwise, several distributed ledgers rely upon modular mechanisms such as consensus or smart contracts. These components, however, can vary substantially among implementations; differences involving proof-of-work, practical byzantine fault tolerance, and other consensus approaches exemplify distinct distributed ledger variations. Such divergence results in unique combinations of modules, performance, latency, and fault tolerance. As implementations continue to develop rapidly due to the emerging nature of blockchain technologies, this paper encapsulates a snapshot of sensor and internet of things (IoT) specific implementations of blockchain as of the end of 2016. Several technical risks and divergent approaches preclude standardization of a blockchain for sensors and IoT in the foreseeable future; such issues will be assessed alongside the practicality of IoT applications among Hyperledger, Iota, and Ethereum distributed ledger implementations suggested for IoT. This paper contributes a comparison of existing distributed ledger implementations intended for practical sensor and IoT utilization. A baseline for characterizing distributed ledger implementations in the context of IoT and sensors is proposed. Technical approaches and performance are compared considering IoT size, weight, and power limitations. Consensus and smart contracts, if applied, are also analyzed for the respective implementations' practicality and security. Overall, the maturity of distributed ledgers with respect to sensor and IoT applicability will be analyzed for enterprise interoperability.

Unimolecular Micelles of Amphiphilic Cyclodextrin-Core Star-Like Copolymers with Covalent pH-Responsive Linkage of Anticancer Prodrugs.

PubMed

Jia, Tao; Huang, Shuo; Yang, Cangjie; Wang, Mingfeng

2017-08-07

Multifunctional stable and stimuli-responsive drug delivery systems are important for efficient cancer treatment due to their advantages such as enhanced cancer-targeting efficiency, improved pharmacokinetics, minimized drug leaching, and reduced undesirable side effects. Here we report a robust and pH-responsive anticancer drug delivery system based on unimolecular micelles of star-like amphiphilic copolymers. The polymers (denoted as CPOFs) were facilely synthesized via one-step atom transfer radical polymerization of functionalizable benzoaldehyde and hydrophilic poly[(oligo ethylene glycol) methyl ether methacrylate] as comonomers from the core of heptakis [2,3,6-tri-o-(2-bromo-2-methyl propionyl]-β-cyclodextrin as the initiator. Doxorubicin (DOX) as an anticancer drug was covalently linked to the benzoaldehyde groups of CPOFs through pH-sensitive Schiff-base bonds. The DOX-conjugated polymers, denoted as CPOF-DOX, formed robust unimolecular micelles with an average diameter of 18 nm in aqueous media. More importantly, these unimolecular micelles showed higher drug loading capacity and more controllable drug release characteristics, compared to our previous unimolecular micelles of β-cyclodextrin-poly(lactic acid)-b-poly[(oligo ethylene glycol) methyl ether methacrylates] that physically encapsulated DOX via hydrophobic interaction. Moreover, the CPOF-DOX unimolecular micelles could be internalized by human cervical cancer HeLa cells in a stepwise way and showed less cytotoxicity compared to carrier-free DOX. We foresee that CPOF-DOX would provide a promising robust and controllable anticancer drug delivery system for future animal study and clinical trials for cancer treatment.

Sustainable fuel for the transportation sector.

PubMed

Agrawal, Rakesh; Singh, Navneet R; Ribeiro, Fabio H; Delgass, W Nicholas

2007-03-20

A hybrid hydrogen-carbon (H(2)CAR) process for the production of liquid hydrocarbon fuels is proposed wherein biomass is the carbon source and hydrogen is supplied from carbon-free energy. To implement this concept, a process has been designed to co-feed a biomass gasifier with H(2) and CO(2) recycled from the H(2)-CO to liquid conversion reactor. Modeling of this biomass to liquids process has identified several major advantages of the H(2)CAR process. (i) The land area needed to grow the biomass is <40% of that needed by other routes that solely use biomass to support the entire transportation sector. (ii) Whereas the literature estimates known processes to be able to produce approximately 30% of the United States transportation fuel from the annual biomass of 1.366 billion tons, the H(2)CAR process shows the potential to supply the entire United States transportation sector from that quantity of biomass. (iii) The synthesized liquid provides H(2) storage in an open loop system. (iv) Reduction to practice of the H(2)CAR route has the potential to provide the transportation sector for the foreseeable future, using the existing infrastructure. The rationale of using H(2) in the H(2)CAR process is explained by the significantly higher annualized average solar energy conversion efficiency for hydrogen generation versus that for biomass growth. For coal to liquids, the advantage of H(2)CAR is that there is no additional CO(2) release to the atmosphere due to the replacement of petroleum with coal, thus eliminating the need to sequester CO(2).

Glucose-Stimulated Calcium Dynamics in Islets of Langerhans in Acute Mouse Pancreas Tissue Slices

PubMed Central

Stožer, Andraž; Dolenšek, Jurij; Rupnik, Marjan Slak

2013-01-01

In endocrine cells within islets of Langerhans calcium ions couple cell stimulation to hormone secretion. Since the advent of modern fluorimetry, numerous in vitro studies employing primarily isolated mouse islets have investigated the effects of various secretagogues on cytoplasmic calcium, predominantly in insulin-secreting beta cells. Due to technical limitations, insights of these studies are inherently limited to a rather small subpopulation of outermost cells. The results also seem to depend on various factors, like culture conditions and duration, and are not always easily reconcilable with findings in vivo. The main controversies regard the types of calcium oscillations, presence of calcium waves, and the level of synchronized activity. Here, we set out to combine the in situ acute mouse pancreas tissue slice preparation with noninvasive fluorescent calcium labeling and subsequent confocal laser scanning microscopy to shed new light on the existing controversies utilizing an innovative approach enabling the characterization of responses in many cells from all layers of islets. Our experiments reproducibly showed stable fast calcium oscillations on a sustained plateau rather than slow oscillations as the predominant type of response in acute tissue slices, and that calcium waves are the mechanistic substrate for synchronization of oscillations. We also found indirect evidence that even a large amplitude calcium signal was not sufficient and that metabolic activation was necessary to ensure cell synchronization upon stimulation with glucose. Our novel method helped resolve existing controversies and showed the potential to help answer important physiological questions, making it one of the methods of choice for the foreseeable future. PMID:23358454

Uncertainties in the Forecasted Performance of Sediment Diversions Associated with Differences Between "Optimized" Diversion Design Criteria and the Natural Crevasse-Splay Sub-Delta Life-Cycle

NASA Astrophysics Data System (ADS)

Brown, G.

2017-12-01

Sediment diversions have been proposed as a crucial component of the restoration of Coastal Louisiana. They are generally characterized as a means of creating land by mimicking natural crevasse-splay sub-delta processes. However, the criteria that are often promoted to optimize the performance of these diversions (i.e. large, sand-rich diversions into existing, degraded wetlands) are at odds with the natural processes that govern the development of crevasse-splay sub-deltas (typically sand-lean or sand-neutral diversions into open water). This is due in large part to the fact that these optimization criteria have been developed in the absence of consideration for the natural constraints associated with fundamental hydraulics: specifically, the conservation of mechanical energy. Although the implementation of the aforementioned optimization criteria have the potential to greatly increase the land-building capacity of a given diversion, the concomitant widespread inundation of the existing wetlands (an unavoidable consequence of diverting into a shallow, vegetated embayment), and the resultant stresses on existing wetland vegetation, have the potential to dramatically accelerate the loss of these existing wetlands. Hence, there are inherent uncertainties in the forecasted performance of sediment diversions that are designed according to the criteria mentioned above. This talk details the reasons for these uncertainties, using analytic and numerical model results, together with evidence from field observations and experiments. The likelihood that, in the foreseeable future, these uncertainties can be reduced, or even rationally bounded, is discussed.

Multi-Spectral Image Analysis for Improved Space Object Characterization

NASA Astrophysics Data System (ADS)

Duggin, M.; Riker, J.; Glass, W.; Bush, K.; Briscoe, D.; Klein, M.; Pugh, M.; Engberg, B.

The Air Force Research Laboratory (AFRL) is studying the application and utility of various ground based and space-based optical sensors for improving surveillance of space objects in both Low Earth Orbit (LEO) and Geosynchronous Earth Orbit (GEO). At present, ground-based optical and radar sensors provide the bulk of remotely sensed information on satellites and space debris, and will continue to do so into the foreseeable future. However, in recent years, the Space Based Visible (SBV) sensor was used to demonstrate that a synthesis of space-based visible data with ground-based sensor data could provide enhancements to information obtained from any one source in isolation. The incentives for space-based sensing include improved spatial resolution due to the absence of atmospheric effects and cloud cover and increased flexibility for observations. Though ground-based optical sensors can use adaptive optics to somewhat compensate for atmospheric turbulence, cloud cover and absorption are unavoidable. With recent advances in technology, we are in a far better position to consider what might constitute an ideal system to monitor our surroundings in space. This work has begun at the AFRL using detailed optical sensor simulations and analysis techniques to explore the trade space involved in acquiring and processing data from a variety of hypothetical space-based and ground-based sensor systems. In this paper, we briefly review the phenomenology and trade space aspects of what might be required in order to use multiple band-passes, sensor characteristics, and observation and illumination geometries to increase our awareness of objects in space.

Reproductive history and breast cancer risk.

PubMed

Kobayashi, Shunzo; Sugiura, Hiroshi; Ando, Yoshiaki; Shiraki, Norio; Yanagi, Takeshi; Yamashita, Hiroko; Toyama, Tatsuya

2012-10-01

The fact that reproductive factors have significant influence on the risk of breast cancer is well known. Early age of first full-term birth is highly protective against late-onset breast cancers, but each pregnancy, including the first one, increases the risk of early-onset breast cancer. Estradiol and progesterone induce receptor activator of NF-kappa B ligand (RANKL) in estrogen receptor (ER)- and progesterone receptor (PgR)-positive luminal cells. RANKL then acts in a paracrine fashion on the membranous RANK of ER/PgR-negative epithelial stem cells of the breast. This reaction cascade is triggered by chorionic gonadotropin during the first trimester of pregnancy and results in the morphological and functional development of breast tissue. On the other hand, the administration of non-steroidal anti-inflammatory drugs in the early steps of weaning protects against tumor growth through reduction of the acute inflammatory reaction of post lactation remodeling of breast tissue. This is experimental evidence that may explain the short-term tumor-promoting effect of pregnancy. The protective effect of prolonged breast feeding may also be explained, at least in a part, by a reduced inflammatory reaction due to gradual weaning. Delay of first birth together with low parity and short duration of breast feeding are increasing social trends in developed countries. Therefore, breast cancer risk as a result of reproductive factors will not decrease in these countries in the foreseeable future. In this review, the significance of reproductive history with regard to the risk of breast cancers will be discussed, focusing on the age of first full-term birth and post lactation involution of the breast.

Comparative assessment for future prediction of urban water environment using WEAP model: A case study of Kathmandu, Manila and Jakarta

NASA Astrophysics Data System (ADS)

Kumar, Pankaj; Yoshifumi, Masago; Ammar, Rafieiemam; Mishra, Binaya; Fukushi, Ken

2017-04-01

Uncontrolled release of pollutants, increasing extreme weather condition, rapid urbanization and poor governance posing a serious threat to sustainable water resource management in developing urban spaces. Considering half of the world's mega-cities are in the Asia and the Pacific with 1.7 billion people do not access to improved water and sanitation, water security through its proper management is both an increasing concern and an imperative critical need. This research work strives to give a brief glimpse about predicted future water environment in Bagmati, Pasig and Ciliwung rivers from three different cities viz. Manila, Kathmandu and Jakarta respectively. Hydrological model used here to foresee the collective impacts of rapid population growth because of urbanization as well as climate change on unmet demand and water quality in near future time by 2030. All three rivers are major source of water for different usage viz. domestic, industrial, agriculture and recreation but uncontrolled withdrawal and sewerage disposal causing deterioration of water environment in recent past. Water Evaluation and Planning (WEAP) model was used to model river water quality pollution future scenarios using four indicator species i.e. Dissolved Oxygen (DO), Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD) and Nitrate (NO3). Result for simulated water quality as well as unmet demand for year 2030 when compared with that of reference year clearly indicates that not only water quality deteriorates but also unmet demands is increasing in future course of time. This also suggests that current initiatives and policies for water resource management are not sufficient enough and hence immediate and inclusive action through transdisciplinary research.

Economics in the future: towards a new paradigm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dopfer, K.

1976-01-01

The main ideas of economics in the future are set out by the editor, Kurt Dopfer, in the introduction: Towards a New Paradigm. The four postulates are: the need for an holistic approach; the need for a long-run view in economics; the need to view economics as an empirical science; and the need to view economics as political economy. In the second part, ''Selected Topics'', the authors present a detailed account of the future development of the major areas of economics. Jan Tinbergen suggests that economics needs a firm empirical basis if there is to be further development of theoriesmore » for new or neglected areas such as environmental conservation, income distribution or socio-economic development of less-developed countries. Harvey Leibenstein stresses that economic theory will be robbed of its empirical relevance unless it revises some of its basic assumptions, and he suggests a new ''micro-micro-economics''. Sir Roy Harrod draws attention to the fact that contemporary economic theory is still overwhelmingly static and that further development in the area of ''economic dynamics'' is crucial if economics is ever to serve as a basis for economic policy. Gunnar Myrdal delineates a political economy which is based upon an understanding of institutions, relies on empirically well-founded assumptions and pushes itself further within a framework of interdisciplinary research. K. William Kapp shows some of the future possibilities that an interdisciplinary systems approach may offer to future economics and combines them with the concept of ''normative planning''. Shigeto Tsuru foresees the necessity of a new political economy whose basic features reflect the Chinese rather than the Japanese model of capitalism. 122 notes and references.« less

Aquaculture: global status and trends

PubMed Central

Bostock, John; McAndrew, Brendan; Richards, Randolph; Jauncey, Kim; Telfer, Trevor; Lorenzen, Kai; Little, David; Ross, Lindsay; Handisyde, Neil; Gatward, Iain; Corner, Richard

2010-01-01

Aquaculture contributed 43 per cent of aquatic animal food for human consumption in 2007 (e.g. fish, crustaceans and molluscs, but excluding mammals, reptiles and aquatic plants) and is expected to grow further to meet the future demand. It is very diverse and, contrary to many perceptions, dominated by shellfish and herbivorous and omnivorous pond fish either entirely or partly utilizing natural productivity. The rapid growth in the production of carnivorous species such as salmon, shrimp and catfish has been driven by globalizing trade and favourable economics of larger scale intensive farming. Most aquaculture systems rely on low/uncosted environmental goods and services, so a critical issue for the future is whether these are brought into company accounts and the consequent effects this would have on production economics. Failing that, increased competition for natural resources will force governments to allocate strategically or leave the market to determine their use depending on activities that can extract the highest value. Further uncertainties include the impact of climate change, future fisheries supplies (for competition and feed supply), practical limits in terms of scale and in the economics of integration and the development and acceptability of new bio-engineering technologies. In the medium term, increased output is likely to require expansion in new environments, further intensification and efficiency gains for more sustainable and cost-effective production. The trend towards enhanced intensive systems with key monocultures remains strong and, at least for the foreseeable future, will be a significant contributor to future supplies. Dependence on external feeds (including fish), water and energy are key issues. Some new species will enter production and policies that support the reduction of resource footprints and improve integration could lead to new developments as well as reversing decline in some more traditional systems. PMID:20713392

Family members and health professionals' perspectives on future life planning of ageing people with Down syndrome: a qualitative study.

PubMed

Covelli, Venusia; Raggi, Alberto; Paganelli, Chiara; Leonardi, Matilde

2017-08-08

To address the way in which primary caregivers of people over 45 with Down syndrome describe daily life activities and context and foresee their future. Thirteen family members and 15 health professionals participated to four focus groups. Meaningful concepts were identified and linked to the International Classification of Functioning, Disability and Health using established linking rules. A total of 258 relevant concepts were identified and linked to 75 categories of the classification: 38 were from activity and participation and 17 from environmental factors domains. The most commonly reported issues were mental functions (b117-intellectual functions and b152-emotional functions), community life activities (d910-community life and d920-recreation and leisure) and environmental factors (e310-support of immediate family, e355-support from health professionals and e555-associations and organizational services). Information on the daily life and health of ageing people with Down syndrome is important to plan social and health care interventions tailored to deal with problems that they may encounter in older age. Considering the interaction between health and environment and maintaining a continuity of daily routines were reported as the most relevant topics for managing daily lives of persons with Down syndrome in older ages. Implications for rehabilitation Pay more attention to the interaction between environmental factors and health condition in ageing people with Down syndrome. Information about the life contest are important in order to plan present and future social-health care interventions. Future planning for people with Down syndrome is a great concern for family members.

16 CFR 1508.6 - Hardware.

Code of Federal Regulations, 2011 CFR

2011-01-01

... eliminates from any hardware accessible to a child within the crib the possibility of the hardware's... foreseeable damage or abuse. (b) Locking or latching devices used to secure dropside rails shall require a...

16 CFR 1508.6 - Hardware.

Code of Federal Regulations, 2010 CFR

2010-01-01

... eliminates from any hardware accessible to a child within the crib the possibility of the hardware's... foreseeable damage or abuse. (b) Locking or latching devices used to secure dropside rails shall require a...

Major Accidents (Gray Swans) Likelihood Modeling Using Accident Precursors and Approximate Reasoning.

PubMed

Khakzad, Nima; Khan, Faisal; Amyotte, Paul

2015-07-01

Compared to the remarkable progress in risk analysis of normal accidents, the risk analysis of major accidents has not been so well-established, partly due to the complexity of such accidents and partly due to low probabilities involved. The issue of low probabilities normally arises from the scarcity of major accidents' relevant data since such accidents are few and far between. In this work, knowing that major accidents are frequently preceded by accident precursors, a novel precursor-based methodology has been developed for likelihood modeling of major accidents in critical infrastructures based on a unique combination of accident precursor data, information theory, and approximate reasoning. For this purpose, we have introduced an innovative application of information analysis to identify the most informative near accident of a major accident. The observed data of the near accident were then used to establish predictive scenarios to foresee the occurrence of the major accident. We verified the methodology using offshore blowouts in the Gulf of Mexico, and then demonstrated its application to dam breaches in the United Sates. © 2015 Society for Risk Analysis.

CFD model simulation of LPG dispersion in urban areas

NASA Astrophysics Data System (ADS)

Pontiggia, Marco; Landucci, Gabriele; Busini, Valentina; Derudi, Marco; Alba, Mario; Scaioni, Marco; Bonvicini, Sarah; Cozzani, Valerio; Rota, Renato

2011-08-01

There is an increasing concern related to the releases of industrial hazardous materials (either toxic or flammable) due to terrorist attacks or accidental events in congested industrial or urban areas. In particular, a reliable estimation of the hazardous cloud footprint as a function of time is required to assist emergency response decision and planning as a primary element of any Decision Support System. Among the various hazardous materials, the hazard due to the road and rail transportation of liquefied petroleum gas (LPG) is well known since large quantities of LPG are commercialized and the rail or road transportation patterns are often close to downtown areas. Since it is well known that the widely-used dispersion models do not account for the effects of any obstacle like buildings, tanks, railcars, or trees, in this paper a CFD model has been applied to simulate the reported consequences of a recent major accident involving an LPG railcar rupture in a congested urban area (Viareggio town, in Italy), showing both the large influence of the obstacles on LPG dispersion as well as the potentials of CFD models to foresee such an influence.

Reductions without Regret: Avoiding Wrong Turns, Roach Motels, and Box Canyons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swegle, John A.; Tincher, Douglas J.

This is the third of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as somemore » closing thoughts for the future. In this paper, we provide one example each of our judgments on what constitutes a box canyon, a roach motel, and a wrong turn: Wrong Turn: The Reliable Replacement Warhead: Roach Motel: SRAM T vs the B61: and A Possible Box Canyon: A Low-Yield Version of the W76 SLBM Warhead. Recognizing that new nuclear missions or weapons are not demanded by current circumstances ₋ a development path that yields future capabilities similar to those of today, which are adequate if not always ideal, and a broader national-security strategy that supports nonproliferation and arms control by reducing the role for, and numbers, of nuclear weapons ₋ we briefly consider alternate, less desirable futures, and their possible effect on the complex problem of regional deterrence. In this regard, we discuss the issues posed by, and possible responses to, three example regional deterrence challenges: in-country defensive use of nuclear weapons by an adversary; reassurance of U.S. allies with limited strategic depth threatened by an emergent nuclear power; and extraterritorial, non-strategic offensive use of nuclear weapons by an adversary in support of limited military objectives against a U.S. ally.« less

Theory of reflectivity blurring in seismic depth imaging

NASA Astrophysics Data System (ADS)

Thomson, C. J.; Kitchenside, P. W.; Fletcher, R. P.

2016-05-01

A subsurface extended image gather obtained during controlled-source depth imaging yields a blurred kernel of an interface reflection operator. This reflectivity kernel or reflection function is comprised of the interface plane-wave reflection coefficients and so, in principle, the gather contains amplitude versus offset or angle information. We present a modelling theory for extended image gathers that accounts for variable illumination and blurring, under the assumption of a good migration-velocity model. The method involves forward modelling as well as migration or back propagation so as to define a receiver-side blurring function, which contains the effects of the detector array for a given shot. Composition with the modelled incident wave and summation over shots then yields an overall blurring function that relates the reflectivity to the extended image gather obtained from field data. The spatial evolution or instability of blurring functions is a key concept and there is generally not just spatial blurring in the apparent reflectivity, but also slowness or angle blurring. Gridded blurring functions can be estimated with, for example, a reverse-time migration modelling engine. A calibration step is required to account for ad hoc band limitedness in the modelling and the method also exploits blurring-function reciprocity. To demonstrate the concepts, we show numerical examples of various quantities using the well-known SIGSBEE test model and a simple salt-body overburden model, both for 2-D. The moderately strong slowness/angle blurring in the latter model suggests that the effect on amplitude versus offset or angle analysis should be considered in more realistic structures. Although the description and examples are for 2-D, the extension to 3-D is conceptually straightforward. The computational cost of overall blurring functions implies their targeted use for the foreseeable future, for example, in reservoir characterization. The description is for scalar waves, but the extension to elasticity is foreseeable and we emphasize the separation of the overburden and survey-geometry blurring effects from the nature of the target scatterer.

76 FR 23337 - Warner Valley Comprehensive Site Plan/Environmental Impact Statement, Lassen Volcanic National...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

..., including incrementional lowering and removal of Dream Lake Dam, rehabilitation of drainage ditches in... foreseeable environmental consequences were assessed, and appropriate mitigation measures are incorporated in...

22 CFR 503.9 - Electronic records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... foreseeable harm to any interest protected by an FOIA exemption. (3) Electronic reading room. The room... for faster processing, you may limit the scope of your request so that we may respond more quickly. (2...

22 CFR 503.9 - Electronic records.

Code of Federal Regulations, 2011 CFR

2011-04-01

... foreseeable harm to any interest protected by an FOIA exemption. (3) Electronic reading room. The room... for faster processing, you may limit the scope of your request so that we may respond more quickly. (2...

Experts Foresee a Major Shift From Inpatient to Ambulatory Care.

PubMed

Beans, Bruce E

2016-04-01

An American Society of Health-System Pharmacists Research and Education Foundation report predicts trends in health care delivery and financing, drug development and therapeutics, pharmaceutical marketplace, pharmacy workforce, and more.

16 CFR 1207.4 - Recommended standards for materials of manufacture.

Code of Federal Regulations, 2011 CFR

2011-01-01

... exposure to rain, snow, ice, sunlight, local, normal temperature extremes, local normal wind variations... be toxic to man or harmful to the environment under intended use and reasonably foreseeable abuse or...

16 CFR 1207.4 - Recommended standards for materials of manufacture.

Code of Federal Regulations, 2012 CFR

2012-01-01

... exposure to rain, snow, ice, sunlight, local, normal temperature extremes, local normal wind variations... be toxic to man or harmful to the environment under intended use and reasonably foreseeable abuse or...

16 CFR 1207.4 - Recommended standards for materials of manufacture.

Code of Federal Regulations, 2014 CFR

2014-01-01

... exposure to rain, snow, ice, sunlight, local, normal temperature extremes, local normal wind variations... be toxic to man or harmful to the environment under intended use and reasonably foreseeable abuse or...

16 CFR 1207.4 - Recommended standards for materials of manufacture.

Code of Federal Regulations, 2010 CFR

2010-01-01

... exposure to rain, snow, ice, sunlight, local, normal temperature extremes, local normal wind variations... be toxic to man or harmful to the environment under intended use and reasonably foreseeable abuse or...

Picking up the shield: Incorporating defense into strategic nuclear doctrine. Research report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruotsala, M.G.

Picking up the Shield is an interesting and enlightening account of the evolution of strategic nuclear doctrine. It puts the offense-defense relationship into a historical perspective that lends important insight into the ongoing debate over strategic defenses. Although this debate centers on the active defenses contemplated by the strategic defense initiative, Lt Col Michael G. Ruotsala makes the point that passive defenses are also an important component of strategic defense. He sees the inherent passive defenses of the Triad as being a key to maintaining offense-oriented deterrence, and he makes a good case for survivable Peacekeeper basing and a smallmore » mobile intercontinental ballistic missile (ICBM) to enhance deterrence and pave the way for active defense. Although the future may hold a strategic defense with new, even revolutionary, weapons, any future program will embody old concepts of offense and defense. For the foreseeable future, offensive strategic forces will continue to play a dominant role in US defense policy. However, strategic defenses are consistent with US strategic doctrine. More important for deterrence, defenses are consistent with Soviet doctrine. Clearly, complementing roles for both the offense and defense are critical for developing a doctrine that enhances deterrence of a nuclear exchange between the United States and the Soviet Union. It is also clear that Picking up the Shield makes a significant contribution to understanding the challenge we face as we incorporate defense into strategic nuclear doctrine.« less

Sustainable medicines and global health care.

PubMed

Cordell, Geoffrey A

2011-07-01

The global population has now exceeded 7 billion, and forests and other resources around the world are being irreversibly depleted for energy, food, shelter, material goods, and drugs to accommodate population needs. For most of the world's population, plants, based on many well-established systems of medicine, in either crude or extract form, represent the foundation of primary health care for the foreseeable future. Contemporary harvesting methods for medicinal plants are severely depleting these critical indigenous resources. However, maintaining and enhancing the availability of quality medicinal agents on a sustainable basis is an unappreciated public health care concept. To accomplish these goals for future health care, and restore the health of the Earth, a profound paradigm shift is necessary: ALL medicinal agents should be regarded as a sustainable commodity, irrespective of their source. Several approaches to enhancing the availability of safe and efficacious plant-based medicinal agents will be presented including integrated strategies to manifest the four pillars (information, botany, chemistry, and biology) for medicinal plant quality control. These integrated initiatives involve information systems, DNA barcoding, metabolomics, biotechnology, nanotechnology, in-field analysis of medicinal plants, and the application of new detection techniques for the development of medicinal plants with enhanced levels of safe and reproducible biological agents. © Georg Thieme Verlag KG Stuttgart · New York.

Tropical forests: present status and future outlook.

PubMed

Myers, N

1991-09-01

Tropical forests still cover almost 8 million km squared of the humid tropics but they are being destroyed at ever-more rapid rates. In 1989, the area deforested amounted to 142,200 km squared, or nearly 90% more than in 1979. Thus, whereas the 1989 amounted total to 1.8% of the remaining biome, the proportion could well continue to rise for the foreseeable future, until there is little forest in just a few decades. Deforestati on patterns are far from even throughout the biome. In much of the Southeast and Southern Asia, East and West Africa, and Central America, there is likely to be little forest left by the year 2000 or shortly thereafter. But in the Zaire basin, western Brazilian Amazonia, and the Guyana highlands, sizeable expanses of forest could persist a good while longer. The main agent of deforestation in the 'shifted cultivator' or displaced peasant, who, responding to land hunger and general lack of rural development in traditional farming areas of countries concerned, feels there is no alternative but to adopt a slash-and-burn lifestyle in forestlands. This person is now accounting for at least 60% of deforestation, a rapidly expanding proportion. However, he receives far less policy attention than the commercial logger, the cattle rancher, and other agents of deforestation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, Feroz Hassan; Vannoni, Michael Geoffrey; Rajen, Gaurav

India and Pakistan have created sizeable ballistic missile forces and are continuing to develop and enlarge them. These forces can be both stabilizing (e.g., providing a survivable force for deterrence) and destabilizing (e.g., creating strategic asymmetries). Missile forces will be a factor in bilateral relations for the foreseeable future, so restraint is necessary to curtail their destabilizing effects. Such restraint, however, must develop within an atmosphere of low trust. This report presents a set of political and operational options, both unilateral and bilateral, that decreases tensions, helps rebuild the bilateral relationship, and prepares the ground for future steps in structuralmore » arms control. Significant steps, which build on precedents and do not require extensive cooperation, are possible despite strained relations. The approach is made up of three distinct phases: (1) tension reduction measures, (2) confidence building measures, and (3) arms control agreements. The goal of the first phase is to initiate unilateral steps that are substantive and decrease tensions, establish missiles as a security topic for bilateral discussion, and set precedents for limited bilateral cooperation. The second phase would build confidence by expanding current bilateral security agreements, formalizing bilateral understandings, and beginning discussion of monitoring procedures. The third phase could include bilateral agreements limiting some characteristics of national missile forces including the cooperative incorporation of monitoring and verification.« less

Laying the foundation for a digital Nova Scotia

NASA Astrophysics Data System (ADS)

Bond, J.

2016-04-01

In 2013, the Province of Nova Scotia began an effort to modernize its coordinate referencing infrastructure known as the Nova Scotia Coordinate Referencing System (NSCRS). At that time, 8, active GPS stations were installed in southwest Nova Scotia to evaluate the technology's ability to address the Province's coordinate referencing needs. The success of the test phase helped build a business case to implement the technology across the entire Province. It is anticipated that by the end of 2015, 40 active GPS stations will be in place across Nova Scotia. This infrastructure, known as the Nova Scotia Active Control Stations (NSACS) network, will allow for instantaneous, centimetre level positioning across the Province. Originally designed to address the needs of the surveying community, the technology has also proven to have applications in mapping, machine automation, agriculture, navigation, emergency response, earthquake detection and other areas. In the foreseeable future, all spatial data sets captured in Nova Scotia will be either directly or indirectly derived from the NSACS network. The technology will promote high accuracy and homogenous spatial data sets across the Province. The technology behind the NSACS and the development of the system are described. Examples of how the technology is contributing to a digital Nova Scotia are presented. Future applications of the technology are also considered.

Thermonuclear peace, the tightrope of deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uscher, A.R.

This policy analysis focuses on the actions and approaches that will best reduce the chances of nuclear war in a MAD world, where mutual terror and mutual dependence will define our bipolar environment for the foreseeable future. The general approach to this broad and complex issue can be summarized as follows: since plans for conducting and preventing nuclear war are likely to be self-fulfilling prophecies, the US should strive for rational declaratory and deployment policies that reduce the chance of nuclear conflict while maintaining our national-security interests. Stability, probably the single most-important and unifying theme in nuclear deterrence, is visualizedmore » as a set of incentive structures that create no perceived advantages in escalating at any point along a hypothetical-force continuum. The key element in establishing and maintaining superpower stability is the inability to achieve adequate damage limitation through a preemptive first strike. The power and number of nuclear weapons compared to the fragility and limited number of priority targets seriously challenge the utility of most defensive measures. Successfully walking the tightrope of deterrence will require careful balancing of legitimate and competing values. This is a difficult task, but with a clear and realistic vision of the future, it is a feasible one.« less

Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF.

PubMed

Weyer, Karin; Mirzayev, Fuad; Migliori, Giovanni Battista; Van Gemert, Wayne; D'Ambrosio, Lia; Zignol, Matteo; Floyd, Katherine; Centis, Rosella; Cirillo, Daniela M; Tortoli, Enrico; Gilpin, Chris; de Dieu Iragena, Jean; Falzon, Dennis; Raviglione, Mario

2013-07-01

If tuberculosis (TB) is to be eliminated as a global health problem in the foreseeable future, improved detection of patients, earlier diagnosis and timely identification of rifampicin resistance will be critical. New diagnostics released in recent years have improved this perspective but they require investments in laboratory infrastructure, biosafety and staff specialisation beyond the means of many resource-constrained settings where most patients live. Xpert MTB/RIF, a new assay employing automated nucleic acid amplification to detect Mycobacterium tuberculosis, as well as mutations that confer rifampicin resistance, holds the promise to largely overcome these operational challenges. In this article we position Xpert MTB/RIF in today's TB diagnostic landscape and describe its additional potential as an adjunct to surveillance and surveys, taking into account considerations of pricing and ethics. In what could serve as a model for the future formulation of new policy on diagnostics, we trace the unique process by which the World Health Organization consulted international expertise and systematically assessed published evidence and freshly emerging experience from the field ahead of its endorsement of the Xpert MTB/RIF technology in 2010, summarise subsequent research findings and guidance on who to test and how, and provide perspectives on scaling up the new technology.