Review of Systemic Treatment Options for Adult Atopic Dermatitis.

PubMed

Gooderham, Melinda; Lynde, Charles W; Papp, Kim; Bourcier, Marc; Guenther, Lyn; Gulliver, Wayne; Hong, Chih-Ho; Poulin, Yves; Sussman, Gordon; Vender, Ronald

Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease resulting from defects in skin barrier and aberrant immune responses. AD significantly affects the quality of life. Not all patients respond to topical therapies, and often systemic therapy is required to control the disease. To review the treatment options for adult AD patients including those options for patients who do not respond adequately or have contraindications to oral systemic therapy. A working group of clinicians with experience managing AD was convened to review the current literature on treatment options for adult AD patients. This review is based on the best available evidence from a published systematic review and an additional literature search. Current treatments for AD are reviewed, including options for adult AD patients who do not respond or have contraindications to current systemic therapies. A new approach with targeted therapies is reviewed based on best available evidence. Many AD patients respond satisfactorily to topical or systemic treatments, but for those patients who do not respond or have contraindications, new biologic agents appear to be promising therapies.

Oral ivermectin for the treatment of head lice infestation.

PubMed

Sanchezruiz, Wendy L; Nuzum, Donald S; Kouzi, Samir A

2018-05-22

Published literature describing the use of oral ivermectin for the treatment of head lice infestation is reviewed. In the United States and globally, head lice infestation, or pediculosis capitis, remains a public health issue with both social and medical implications. Treatment with oral or topical medications is typically required for head lice eradication. Resistance to traditional topical therapies for head lice infestation is increasing, creating a need for consideration of additional treatment options. A growing body of data describing the potential role of oral ivermectin for the treatment or prevention of head lice infestation is available. A literature search identified 5 clinical trials that evaluated safety and/or effectiveness outcomes of oral ivermectin use as an alternative to malathion, other topical prescription medications, and traditional, nonprescription remedies; those studies were conducted in various parts of the world (e.g., Australia, Brazil, Mexico, Egypt) and likely involved varying types and degrees of lice resistance. Clinical research findings to date, while not consistently robust, suggest that oral ivermectin is comparable or superior in effectiveness to other topical treatment options for head lice infestation while being well tolerated and favorably perceived by patients and caretakers. Oral ivermectin is an option for the treatment of head lice infestation, especially in individuals who have experienced a treatment failure. Published evidence from clinical trials indicates that oral ivermectin is as effective as currently available topical treatments. Copyright © 2018 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Safety and Efficacy of Topical Lime Sulfur in Mice Infested with Myocoptes musculinus

PubMed Central

Wood, Jennifer S; Courtney, Cynthia L; Lieber, Karen A; Lee, Vanessa K

2013-01-01

Current treatment options for murine fur mites have limitations in safety and efficacy. This study evaluated whether topical lime sulfur (LS) is an adjunct or alternative to traditional treatment options for Myocoptes musculinus. To evaluate the safety of topical LS, mice were dipped in a 3% LS solution at 34 and 41 d of age. Mice were observed daily for side effects and mortality, with blood work and necropsy at 42 d of age to evaluate for pathologic changes. To determine the efficacy of topical LS, postweanling mice infested with M. musculinus were treated with LS once weekly for 2 wk and then housed with uninfested sentinel mice for 4 wk. Weekly tape tests and postmortem tape tests and skin scrapings were performed on all mice. Treated postweanling mice had significantly lower Hgb levels and higher BUN levels than did control animals. In mite-infested mice, the number of positive cages at euthanasia was the same between treated and control animals. Although topical LS did not cause gross or microscopic changes to organ systems, it may cause clinicopathologic changes, and topical LS is not effective as a sole treatment for M. musculinus infestation of postweanling mice. PMID:23849408

Writing-Intensive Astronomy Classes in a Liberal Arts Setting

NASA Astrophysics Data System (ADS)

Schmidtke, P. C.

2013-04-01

The Integrative Studies Program at Arizona State University is a modern adaptation of a traditional liberal arts degree. An important component of the curriculum is the requirement for a course in the area of “math and science perspectives.” Among the options are two classes on Life in the Universe and Black Holes and Beyond. These classes present contemporary astronomy topics in a format designed for humanities-oriented students. Course material is developed via class discussion of readings, augmented by a wide range of hands-on activities, and organized within the BlackBoard course management system. Almost all assignments are writing intensive: daily journals, formal papers, and an essay-type exam. The design of these courses makes them highly interactive between the instructor and students.

CFB repowering options

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gittinger, J.

1996-12-31

Circulating fluidized bed CFB repowering options are summarized. The following topics are discussed: why repower with CFB technology; advantages of repowering; two forms of of repowering; B and N`s internal recirculation CFB; space-saving design features; cost-saving design features; Ukrainian repowering project; and candidates for repowering.

Emerging Therapies for Scar Prevention

PubMed Central

Block, Lisa; Gosain, Ankush; King, Timothy W.

2015-01-01

Significance: There are ∼12 million traumatic lacerations treated in the United States emergency rooms each year, 250 million surgical incisions created worldwide every year, and 11 million burns severe enough to warrant medical treatment worldwide. In the United States, over $20 billion dollars per year are spent on the treatment and management of scars. Recent Advances: Investigations into the management of scar therapies over the last decade have advanced our understanding related to the care of cutaneous scars. Scar treatment methods are presented including topical, intralesional, and mechanical therapies in addition to cryotherapy, radiotherapy, and laser therapy. Critical Issues: Current treatment options for scars have significant limitations. This review presents the current and emerging therapies available for scar management and the scientific evidence for scar management is discussed. Future Directions: Based upon our new understanding of scar formation, innovative scar therapies are being developed. Additional research on the basic science of scar formation will lead to additional advances and novel therapies for the treatment of cutaneous scars. PMID:26487979

From Earth to orbit. [assessment of transportation options

NASA Technical Reports Server (NTRS)

Gavin, Joseph G., Jr.; Blond, Edmund; Brill, Yvonne C.; Budiansky, Bernard; Cooper, Robert S.; Demisch, Wolfgang H.; Hawk, Clark W.; Kerrebrock, Jack L.; Lichtenberg, Byron K.; Mager, Arthur

1992-01-01

Within this document, the National Research Council (NRC) assesses the requirements, benefits, technological feasibility, and roles of Earth-to-orbit transportation options that could be developed in support of the national space program. Among the topics covered are launch vehicles and infrastructure, propulsion, and technology.

Experiment definition phase shuttle laboratory (LDRL-10.6 experiment): Shuttle sortie to elliptical orbit satellite

NASA Technical Reports Server (NTRS)

Goodwin, F. E.; Nussmeier, T. A.; Stokes, L. S.; Vourgourakis, E. J.

1976-01-01

The following topics were reviewed: (1) design options for shuttle terminal, (2) elliptical orbit satellite design options, (3) shuttle terminal details, (4) technology status and development requirements, (5) transmitter technology, and (6) carbon dioxide laser life studies.

Oily Skin: A review of Treatment Options

PubMed Central

Miller, Richard A.

2017-01-01

One of the most common dermatologic concerns is oily skin, and the demand for effective treatment options is ever apparent. This review article addresses numerous topical treatment options such as retinoids, olumacostat glasaretil, and various cosmeceutical agents. several systemic and procedural techniques that incorporate isotretinoin, spironolactone, oral contraceptives, botulinum toxin, photodynamic therapy, and lasers are reviewed as well. Each treatment option is analyzed in terms of the proposed mechanism of action, efficacy reported in the literature, and potential adverse effects. PMID:28979664

DOE Office of Scientific and Technical Information (OSTI.GOV)

Funk, David John

The topic is presented in a series of slides arranged according to the following outline: LANL nitrate salt incident as thermal runaway (thermally sensitive surrogates, full-scale tests), temperature control for processing, treatment options and down selection, assessment of engineering options, anticipated control set for treatment, and summary of the overall steps for RNS.

Distributing the Wealth: Sliding CD-ROM into the Consumer Channel.

ERIC Educational Resources Information Center

Bowers, Richard A.

1994-01-01

Examines retail sales of CD-ROMs. Topics addressed include the current situation in CD-ROM retailing; channel distribution options; myths and realities of CD-ROM distribution; the distributor; affiliate labels; sales representatives; copublishers; distribution options; distributing resources; and recommendations for new CD-ROM publishers. (LRW)

Sexuality education in fifth and sixth grades in U.S. public schools, 1999.

PubMed

Landry, D J; Singh, S; Darroch, J E

2000-01-01

While policymakers, educators and parents recognize the need for family life and sexuality education during children's formative years and before adolescence, there is little nationally representative information on the timing and content of such instruction in elementary schools. In 1999, data were gathered from 1, 789 fifth- and sixth-grade teachers as part of a nationally representative survey of 5,543 public school teachers in grades 5-12. Based on the responses of 617 fifth- and sixth-grade teachers who said they teach sexuality education, analyses were carried out on the topics and skills sexuality education teachers taught, the grades in which they taught them, their teaching approaches, the pressures they experienced, whether they received support from parents, the community and school administrators, and their needs. Seventy-two percent of fifth- and sixth-grade teachers report that sexuality education is taught in their schools at one or both grades. Fifty-six percent of teachers say that the subject is taught in grade five and 64% in grade six. More than 75% of teachers who teach sexuality education in these grades cover puberty, HIV and AIDS transmission and issues such as how alcohol and drugs affect behavior and how to stick with a decision. However, when schools that do not provide sexuality education are taken into account, even most of these topics are taught in only a little more than half of fifth- and sixth-grade classrooms. All other topics are much less likely to be covered. Teaching of all topics is less prevalent at these grades than teachers think it should be. Gaps between what teachers say they are teaching and teachers' recommendations for what should be taught and by what grade are especially large for such topics as sexual abuse, sexual orientation, abortion, birth control and condom use for STD prevention. A substantial proportion of teachers recommend that these topics be taught at grade six or earlier. More than half (57%) of fifth- and sixth-grade sexuality education teachers cover the topic of abstinence from intercourse--17% as the only option for protection against pregnancy and STDs and 40% as the best alternative or one option for such protection. Forty-six percent of teachers report that one of their top three problems in teaching sexuality education is pressure, whether from the community, parents or school administrators. More than 40% of teachers report a need for some type of assistance with materials, factual information or teaching strategies. A large proportion of schools are doing little to prepare students in grades five and six for puberty, much less for dealing with pressures and decisions regarding sexual activity Sexuality education teachers often feel unsupported by the community, parents or school administrators.

What’s Important to the Patient?: Informational Needs of Patients Making Decisions about Hepatitis C Treatment

PubMed Central

Evon, Donna M.; Golin, Carol E.; Stoica, Teodora; Jones, Rachel; Willis, Sarah; Galanko, Joseph; Fried, Michael W.

2017-01-01

Background & Objectives Multiple treatment options with direct-acting antivirals (DAAs) are now available for hepatitis C virus (HCV). Study aims were to understand (1) The informational topics patients want to have to make informed treatment decisions; (2) The importance patients place on each topic; and (3) The topics patients prioritize as most important. Methods Mixed methods study utilizing two samples recruited from an academic liver center. Participants were not currently on treatment. Sample I (n=45) free-listed all informational topics deemed important to decision-making. Raw responses were coded into several broad and subcategories. Sample II (n=38) rated the importance of the subcategories from Sample I and ranked their highest priorities on two surveys, one containing topics for which sufficient research existed to inform patients (“static”), and the other containing topics that would require additional research. Results The topics listed by Sample I fell into 6 broad categories with 17 total subcategories. The most oft-cited informational topics were harms of treatment (100%), treatment benefits (62%) and treatment regimen details (84%). Sample II rated 16 of 17 subcategories as “pretty important’ or “extremely important.” Sample II prioritized (1) viral cure, (2) long-term survival, and (3) side effects on the survey of topics requiring additional research, and (1) liver disease, (2) lifestyle changes, and (3) medication details on the second survey of the most important static topics patients needed. Conclusions Patients weighed several informational topics to make an informed decision about HCV treatment. These findings lay the groundwork for future patient-centered outcomes research in HCV and patient-provider communication to enhance patients’ informed decision-making regarding DAA treatment options. PMID:27882509

Effluent treatment for nuclear thermal propulsion ground testing

NASA Technical Reports Server (NTRS)

Shipers, Larry R.

1993-01-01

The objectives are to define treatment functions, review concept options, discuss PIPET effluent treatment system (ETS), and outline future activities. The topics covered include the following: reactor exhaust; effluent treatment functions; effluent treatment categories; effluent treatment options; concept evaluation; PIPETS ETS envelope; PIPET effluent treatment concept; and future activities.

Multi-band gap and new solar cell options workshop

NASA Technical Reports Server (NTRS)

Hutchby, J.; Timmons, M.; Olson, J. M.

1993-01-01

Discussions of the multi-band gap (MBG) and new solar cell options workshop are presented. Topics discussed include: greater than 2 terminal cells; radiation damage preventing development of MBG cells for space; lattice matching; measurement of true performance; future of II-VI materials in MBG devices; and quaternaries.

Nail Psoriasis: A Review of Treatment Options.

PubMed

Pasch, Marcel C

2016-04-01

Nail involvement affects 80-90 % of patients with plaque psoriasis, and is even more prevalent in patients with psoriatic arthritis. This review is the result of a systemic approach to the literature and covers topical, intralesional, conventional systemic, and biologic systemic treatments, as well as non-pharmacological treatment options for nail psoriasis. The available evidence suggests that all anti-tumor necrosis factor-α, anti-interleukin (IL)-17, and anti-IL-12/23 antibodies which are available for plaque psoriasis and psoriatic arthritis are highly effective treatments for nail psoriasis. Conventional systemic treatments, including methotrexate, cyclosporine, acitretin, and apremilast, as well as intralesional corticosteroids, can also be effective treatments for nail psoriasis. Topical treatments, including corticosteroids, calcipotriol, tacrolimus, and tazarotene, have also been shown to have a position in the treatment of nail psoriasis, particularly in mild cases. Finally, non-pharmacological treatment options, including phototherapy, photodynamic therapy, laser therapy, and several radiotherapeutic options, are also reviewed but cannot be advised as first-line treatment options. Another conclusion of this review is that the lack of a reliable core set of outcomes measures for trials in nail psoriasis hinders the interpretation of results, and is urgently needed.

Public meeting: Western New York Nuclear Service Center options study. [Problem of West Valley plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This document is a transcript of the meeting, with additional written comments. The main topic is the West Valley Processing Plant and how to dispose of it and its high-level wastes. Objective is to get public input on this topic. (DLC)

Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys.

PubMed

Rannou, François; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne

2016-02-01

Topical non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in international and national guidelines as an early treatment option for the symptomatic management of knee and hand osteoarthritis (OA), and may be used ahead of oral NSAIDs due to their superior safety profile. The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends topical NSAIDs for knee OA in addition to the pharmacological background of symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) and rescue analgesia with paracetamol and non-pharmacological treatment, if the patient is still symptomatic. Topical NSAIDs have a moderate effect on pain relief, with efficacy similar to that of oral NSAIDs, with the advantage of a better risk:benefit ratio. In real-life studies, topical and oral NSAIDs demonstrate an equivalent effect on knee pain over 1 year of treatment, with fewer adverse events due to lower systemic absorption of topical NSAIDs compared with oral NSAIDs. As a result, topical NSAIDs may be the preferred treatment option, especially in OA patients aged ≥75 years, and those with co-morbidities or at an increased risk of cardiovascular, gastrointestinal, or renal side effects. Furthermore, using topical NSAIDs in inflammatory rheumatic diseases leads to a 40% reduction in the need for concomitant oral NSAIDs. When selecting a topical NSAID, absorption and bioavailability are important because of heterogeneity among topical drug formulations. Molecules like etofenamate have a bioavailability of >20% and evidence for accumulation in synovial tissues, with efficacy demonstrated as improvement in pain and function in real-life studies of OA patients. Diclofenac also shows good efficacy alongside evidence that diclofenac accumulates in the synovium. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Curbing International Piracy of Intellectual Property. Policy Options for a Major Exporting Country.

ERIC Educational Resources Information Center

Hoffman, Gary M.; Marcou, George T.

This report of the International Piracy Project addresses three major topics: (1) The Costs and Complications of Piracy; (2) Rights Enforcement Today; and (3) Policy Options for Curbing Piracy. The first section discusses piracy of copyrights, patents, and other intellectual property, including economic losses and damage to the finances and…

Document Image Processing: Going beyond the Black-and-White Barrier. Progress, Issues and Options with Greyscale and Colour Image Processing.

ERIC Educational Resources Information Center

Hendley, Tom

1995-01-01

Discussion of digital document image processing focuses on issues and options associated with greyscale and color image processing. Topics include speed; size of original document; scanning resolution; markets for different categories of scanners, including photographic libraries, publishing, and office applications; hybrid systems; data…

The 25 kW power module evolution study. Part 3: Conceptual designs for power module evolution. Volume 4: Design analyses

NASA Technical Reports Server (NTRS)

1979-01-01

Topics covered include growth options evaluation, mass properties, attitude control and structural dynamics, contamination evaluation, berthing concepts, orbit reboost options and growth kit concepts. Systems support elements and space support equipment are reviewed with emphasis on power module operations and technology planning.

Advanced Mathematics 305--Optional Half Credit. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education, Winnipeg.

This manual outlines an advanced mathematics course for secondary school students in Manitoba (Canada). Included are eight different topics for a total of ten modules, with each module accounting for 18 40-minute periods. Teachers, or teachers and students cooperatively, should select the equivalent of five modules from the eight topics covered.…

Macroscopic and microscopic effects of GaAIAs diode laser and dexamethasone therapies on oral mucositis induced by fluorouracil in rats.

PubMed

Lara, Renata Nemetala; da Guerra, Eliete Neves Silva; de Melo, Nilce Santos

2007-01-01

To present an animal model for mucositis induced by fluorouracil in rats, and test two therapeutic options, the GaAIAs laser and topical dexamethasone, analysing them with regard to the quality and quantity of tissue alterations and comparing them with the phases of mucositis. Forty-five Wistar rats (250 g) were treated with fluorouracil (60 mg/kg) and, in order to mimic the clinical effect of chronic irritation, the palatal mucosa was irritated by superficial scratching with an 18-gauge needle. When all of the rats presented oral ulcers of mucositis, they were randomly allocated to one of three groups: group I was treated with laser (GaAIAs), group II was treated with topical dexamethasone, and group III was not treated. Excisional biopsies of the palatal mucosa were then performed, and the rats were killed. Tissue sections were stained with haematoxylin and eosin for morphological analyses, and with toluidine blue for mast-cell counts. Group I specimens showed higher prevalence of ulcers, bacterial biofilm, necrosis and vascularisation, while group II specimens showed higher prevalance of granulation tissue formation. There were no significant statistical differences in the numbers of mast cells and epithelial thickness between groups. For the present model of mucositis, rats with palatal mucositis treated with laser (GaAIAs) showed characteristics compatible with the ulcerative phase of oral mucositis, and rats treated with topical dexamethasone showed characteristics compatible with the healing phase of mucositis. Topical dexamethasone was more efficient in the treatment of rats' oral mucositis than the laser.

A bibliography of stockwork molybdenite deposits and related topics (with an emphasis on the North American literature)

USGS Publications Warehouse

Steigerwald, Celia H.; Mutschler, Felix E.; Ludington, Steve

1983-01-01

This bibliography of 1117 citations brings together references on stockwork molybdenite deposits and related topics in a format that can be sorted by topic and(or) geographic area. Each reference is preceded by a key, or keys, which may be read and sorted visually or by computer, The bibliography is available in two formats: (1) paper- or microfiche-hardcopy, and (2) fixed format computer reasonable magnetic tape, A FORTRAN program is provided for sorting the magnetic tape version,

Solutions and Hope for Severe Behaviors: The Development of Functional Behavioral Assessment

ERIC Educational Resources Information Center

DeLeon, Iser; Silverman, Wayne

2008-01-01

Severe behavior disorders are among the most perplexing conditions encountered by clinicians, and as a front page article in the past Christmas Day's "New York Times" illustrates ("Parents defend school's use of shock therapy"), treatment options remain a topic of contentious debate. Not all that long ago physical restraint was the only option,…

Constraining Second Language Word Order Optionality: Scrambling in Advanced English?German and Japanese?German Interlanguage

ERIC Educational Resources Information Center

Hopp, Holger

2005-01-01

This study documents knowledge of UG-mediated aspects of optionality in word order in the second language (L2) German of advanced English and Japanese speakers (n = 39). A bimodal grammaticality judgement task, which controlled for context and intonation, was administered to probe judgements on a set of scrambling, topicalization and remnant…

A study of space station needs, attributes and architectural options. Final briefing: Cost working group discussion session

NASA Technical Reports Server (NTRS)

1983-01-01

The economic factors involved in the design and utilization of the space station are investigated. Topics include the economic benefits associated with research and production, the orbit transfer vehicle, and satellite servicing. Program costs and design options are examined. The possibilities of financing from the private sector are discussed.

Developing New Pedagogy to Teach Planet Formation to Undergraduate Non-Science Majors

NASA Astrophysics Data System (ADS)

Simon, Molly; Impey, Chris David; Buxner, Sanlyn

2016-06-01

A first order understanding of planet formation and the scientific concepts therein is critical in order for undergraduate students to understand our place in the Universe. Furthermore, planet formation integrates the topics of gravity, angular momentum, migration, and condensation in a “story-book” fashion where students can apply these concepts to a specific event. We collected syllabi and course topics from over 30 undergraduate general-education astrobiology courses from around the globe in order to determine the extent to which professors address planet formation. Additionally, we were looking to see if faculty had developed specific or original pedagogy to teach this topic. We find on average, instructors spend ½ of a lecture discussing planet formation or they leave it out all together. In the classes where planet formation is taught more extensively, instructors use PowerPoint slides or occasional videos to teach the topic. We aim to develop new pedagogy that will allow us to better determine learning gains and student understanding of this critical topic. If students in an astrobiology class are unable to understand how our own Solar System forms, it is significantly more challenging to make parallels (or find differences) between our home in the Universe and extrasolar planetary systems.

Satellite services system analysis study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1981-01-01

Service requirements are considered. Topics include development of on-orbit operations scenarios, service equipment summary, crew interaction, and satellite features facilitating servicing. Service equipment concepts are considered. Topics include payload deployment, close proximity retrieval, on-orbit servicing, backup/contingency, delivery/retrieval of high energy payloads, Earth return, optional service, and advanced capabilities. Program requirements are assessed.

A Review of Topical Diclofenac Use in Musculoskeletal Disease

PubMed Central

Nair, Bindu; Taylor-Gjevre, Regina

2010-01-01

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications for the treatment of musculoskeletal disorders. Osteoarthritis is the most common form of arthritis in humans and its prevalence rises with age. Oral NSAIDs have potential associated toxicities that must be monitored for and can limit the use of these drugs in certain populations including people of older age. Topical NSAIDs are now being recognized as an option for the treatment strategy of osteoarthritis. We review the efficacy and safety of one of the most common topical NSAIDS, topical diclofenac, for the treatment of osteoarthritis. PMID:27713334

Recent developments in membrane-based separations in biotechnology processes: review.

PubMed

Rathore, A S; Shirke, A

2011-01-01

Membrane-based separations are the most ubiquitous unit operations in biotech processes. There are several key reasons for this. First, they can be used with a large variety of applications including clarification, concentration, buffer exchange, purification, and sterilization. Second, they are available in a variety of formats, such as depth filtration, ultrafiltration, diafiltration, nanofiltration, reverse osmosis, and microfiltration. Third, they are simple to operate and are generally robust toward normal variations in feed material and operating parameters. Fourth, membrane-based separations typically require lower capital cost when compared to other processing options. As a result of these advantages, a typical biotech process has anywhere from 10 to 20 membrane-based separation steps. In this article we review the major developments that have occurred on this topic with a focus on developments in the last 5 years.

Engaging a Rural Community with Science through a Science Café

NASA Astrophysics Data System (ADS)

Adams, P. E.

2012-12-01

Public awareness about science and science issues is often lacking in the general community; in a rural community there are even fewer options for an interested person to engage with others on science topics. One approach to address this issue is through the use of the Science Café model of citizen science at the local level. The Science Café concept, for the United States, originated in Boston (http://www.sciencecafes.org/). Science Café events are held in informal settings, such as restaurants, pubs, or coffee houses with presentations being provided by experts on the subject. The format is designed to promote discussion and questions. Fort Hays State University Science and Mathematics Institute (SMEI), located in Hays, KS, is now in its fifth year of hosting a science café in a community of 20,000 people. The program in Hays started as a grassroots effort from an area high school teacher asking SMEI to organize and support the program. Attendance at the Science Café has range from 14 to 75 people (fire code capacity!), with an average attendance of 30 people. The audience for our Science Café has been citizens, college students, high school students, and university faculty. The presenters at the Hays Science Café have ranged from scientists to engineers, high school students to hobbyists. Our topics have ranged from searching for life in the universe, wind energy, paleo-life in Kansas, climate change, honey bees, and planetary science. The program has developed a strong following in the community and has led to the formation of additional Science Café programs in Kansas. Selection of topics is based on community interest and timeliness. Publicity occurs through posters, e-mail, and social media outlets. Participants have found the sessions to be of interest and a place to learn more about the world and become informed about issues in the news. The Science Café in Hays has had a positive impact on the community.

Hyperhidrosis: review of recent advances and new therapeutic options for primary hyperhidrosis.

PubMed

Brown, Ashley L; Gordon, Jennifer; Hill, Samantha

2014-08-01

Primary focal hyperhidrosis is a common condition that negatively impacts quality of life for many pediatric patients and can be challenging to treat. Standard treatments for hyperhidrosis can be used with success in many patients, and newer therapies and techniques offer options that have demonstrated efficacy and safety. This review highlights standard therapies for primary focal hyperhidrosis as well as the most recent technique advancements and alternative treatment options. The standard approach to treating primary focal hyperhidrosis remains initiation of topical preparations, followed by advancement to systemic medications, local administration of medication and/or surgical procedures. Recent studies focus on enhancing tolerability of topical preparations as well as evaluating the efficacy of neuromodulator injections, oral anticholinergic medications and laser therapy. Microwave technology has also been introduced for the treatment of focal hyperhidrosis with promising results. Many therapies exist for hyperhidrosis, and each treatment plan must be evaluated on a patient-by-patient basis. Advances in standard therapies and emergence of new treatment techniques are the main emphases of current published literature on hyperhidrosis. This article presents recent therapeutic options as well as updates on more established strategies to help practitioners treat this challenging condition.

Innovative options for the doctoral dissertation in nursing.

PubMed

Robinson, Susan; Dracup, Kathleen

2008-01-01

The doctoral dissertation is the capstone event of doctoral study. While developing their dissertations, graduate students discover the cutting edge of the discipline, learn the intricacies of the research process, and engage in scientific dialogue with experts in the field. Traditional dissertation formats are confined to the Dissertation Abstracts International and are not easily accessed by clinicians, administrators, and researchers who are most in need of the information. Consequently, the number of universities offering options to the traditional dissertation format is growing. This article describes and compares 2 formats: the traditional dissertation and the publication option. The benefits and challenges of each format to doctoral students and faculty are discussed. The discussion reflects changing trends in the nursing profession as an academic discipline.

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

PubMed Central

Akhmetova, Alma; Allan, Iain U.; Illsley, Matthew J.; Nurgozhin, Talgat; Mikhalovsky, Sergey

2016-01-01

The process of wound healing is often accompanied by bacterial infection or critical colonization, resulting in protracted inflammation, delayed reepithelization, and production of pungent odors. The malodor produced by these wounds may lower health-related quality of life and produce psychological discomfort and social isolation. Current management focuses on reducing bacterial activity within the wound site and absorbing malodorous gases. For example, charcoal-based materials have been incorporated into dressing for direct adsorption of the responsible gases. In addition, multiple topical agents, including silver, iodine, honey, sugar, and essential oils, have been suggested for incorporation into dressings in an attempt to control the underlying bacterial infection. This review describes options for controlling malodor in chronic wounds, the benefits and drawbacks of each topical agent, and their mode of action. We also discuss the use of subjective odor evaluation techniques to assess the efficacy of odor-controlling therapies. The perspectives of employing novel biomaterials and technologies for wound odor management are also presented. PMID:27684356

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds.

PubMed

Akhmetova, Alma; Saliev, Timur; Allan, Iain U; Illsley, Matthew J; Nurgozhin, Talgat; Mikhalovsky, Sergey

The process of wound healing is often accompanied by bacterial infection or critical colonization, resulting in protracted inflammation, delayed reepithelization, and production of pungent odors. The malodor produced by these wounds may lower health-related quality of life and produce psychological discomfort and social isolation. Current management focuses on reducing bacterial activity within the wound site and absorbing malodorous gases. For example, charcoal-based materials have been incorporated into dressing for direct adsorption of the responsible gases. In addition, multiple topical agents, including silver, iodine, honey, sugar, and essential oils, have been suggested for incorporation into dressings in an attempt to control the underlying bacterial infection. This review describes options for controlling malodor in chronic wounds, the benefits and drawbacks of each topical agent, and their mode of action. We also discuss the use of subjective odor evaluation techniques to assess the efficacy of odor-controlling therapies. The perspectives of employing novel biomaterials and technologies for wound odor management are also presented.

Effect of response format on cognitive reflection: Validating a two- and four-option multiple choice question version of the Cognitive Reflection Test.

PubMed

Sirota, Miroslav; Juanchich, Marie

2018-03-27

The Cognitive Reflection Test, measuring intuition inhibition and cognitive reflection, has become extremely popular because it reliably predicts reasoning performance, decision-making, and beliefs. Across studies, the response format of CRT items sometimes differs, based on the assumed construct equivalence of tests with open-ended versus multiple-choice items (the equivalence hypothesis). Evidence and theoretical reasons, however, suggest that the cognitive processes measured by these response formats and their associated performances might differ (the nonequivalence hypothesis). We tested the two hypotheses experimentally by assessing the performance in tests with different response formats and by comparing their predictive and construct validity. In a between-subjects experiment (n = 452), participants answered stem-equivalent CRT items in an open-ended, a two-option, or a four-option response format and then completed tasks on belief bias, denominator neglect, and paranormal beliefs (benchmark indicators of predictive validity), as well as on actively open-minded thinking and numeracy (benchmark indicators of construct validity). We found no significant differences between the three response formats in the numbers of correct responses, the numbers of intuitive responses (with the exception of the two-option version, which had a higher number than the other tests), and the correlational patterns of the indicators of predictive and construct validity. All three test versions were similarly reliable, but the multiple-choice formats were completed more quickly. We speculate that the specific nature of the CRT items helps build construct equivalence among the different response formats. We recommend using the validated multiple-choice version of the CRT presented here, particularly the four-option CRT, for practical and methodological reasons. Supplementary materials and data are available at https://osf.io/mzhyc/ .

A Curriculum Guide to Applications of Science to Technology for Able Learners.

ERIC Educational Resources Information Center

VanTassel-Baska, Joyce, Ed.; And Others

This curriculum guide was developed with the intention of providing an enrichment option for gifted and talented learners who are interested in pursuing current issues and topics in the fields of mathematics and science. The scope of the guide is meant to encompass a year's study of a set of topics which apply mathematics to science and…

The Usefulness of 0.2% Topical Nitroglycerin for Chondrodermatitis Nodularis Helicis.

PubMed

Sanz-Motilva, V; Martorell-Calatayud, A; Gutiérrez García-Rodrigo, C; Hueso-Gabriel, L; García-Melgares, M L; Pelufo-Enguix, C; Alfaro-Rubio, A; Vanaclocha-Sebastián, F

2015-09-01

Chondrodermatitis nodularis helicis (CNH) is a painful idiopathic degenerative condition involving the skin and cartilage of the helix or antihelix of the ear. Topical nitroglycerin 2% is a relatively recent treatment option for CNH that has produced good results, although with adverse effects (17% of cases). The use of a lower concentration would probably achieve similar results with fewer adverse effects. The aim of this study was to evaluate the effectiveness and safety of topical nitroglycerin 0.2% in the treatment of CNH. We performed a retrospective observational study of patients treated in 2 Spanish hospitals between 2012 and 2014. The effectiveness of treatment was determined by clinical photography and assessment of symptoms using a verbal numerical rating scale. Of the 29 patients treated, 93% showed clinical improvement. In the group of responders, mean treatment duration was 1.8 months and mean follow-up was 5.9 months. Overall tolerance was good in all cases. Topical nitroglycerin 0.2% is an effective and well-tolerated conservative treatment option that improves the appearance of lesions and provides symptomatic relief in the majority of patients with CNH. Copyright © 2015 Elsevier España, S.L.U. and AEDV. All rights reserved.

Treatment options for actinic keratoses.

PubMed

McIntyre, William J; Downs, Michael R; Bedwell, Sondra A

2007-09-01

Actinic keratoses are rough, scaly lesions that commonly occur on sun-exposed areas of the skin. The prevalence of the condition increases with age. Actinic keratoses are thought to be carcinomas in situ, which can progress to squamous cell carcinomas. The decision to treat can be based on cosmetic reasons; symptom relief; or, most importantly, the prevention of malignancy and metastasis. Treatment options include ablative (destructive) therapies such as cryosurgery, curettage with electrosurgery, and photodynamic therapy. Topical therapies are used in patients with multiple lesions. Fluorouracil has been the traditional topical treatment for actinic keratoses, although imiquimod 5% cream and diclofenac 3% gel are effective alternative therapies. There are too few controlled trials comparing treatment modalities for physicians to make sound, evidence-based treatment decisions.

A discontinuous Galerkin method for numerical pricing of European options under Heston stochastic volatility

NASA Astrophysics Data System (ADS)

Hozman, J.; Tichý, T.

2016-12-01

The paper is based on the results from our recent research on multidimensional option pricing problems. We focus on European option valuation when the price movement of the underlying asset is driven by a stochastic volatility following a square root process proposed by Heston. The stochastic approach incorporates a new additional spatial variable into this model and makes it very robust, i.e. it provides a framework to price a variety of options that is closer to reality. The main topic is to present the numerical scheme arising from the concept of discontinuous Galerkin methods and applicable to the Heston option pricing model. The numerical results are presented on artificial benchmarks as well as on reference market data.

Topical Rosiglitazone Is an Effective Anti-Scarring Agent in the Cornea

PubMed Central

Huxlin, Krystel R.; Hindman, Holly B.; Jeon, Kye-Im; Bühren, Jens; MacRae, Scott; DeMagistris, Margaret; Ciufo, David; Sime, Patricia J.; Phipps, Richard P.

2013-01-01

Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome proliferator activated receptor gamma (PPARγ), can effectively block scar formation in a cat model of corneal damage. Adult cats underwent bilateral epithelial debridement followed by excimer laser ablation of the central corneal stroma to a depth of ∼160 µm as a means of experimentally inducing a reproducible wound. Eyes were then left untreated, or received 50 µl of either 10 µM Rosiglitazone in DMSO/Celluvisc, DMSO/Celluvisc vehicle or Celluvisc vehicle twice daily for 2 weeks. Cellular aspects of corneal wound healing were evaluated with in vivo confocal imaging and post-mortem immunohistochemistry for alpha smooth muscle actin (αSMA). Impacts of the wound and treatments on optical quality were assessed using wavefront sensing and optical coherence tomography at 2, 4, 8 and 12 weeks post-operatively. In parallel, cat corneal fibroblasts were cultured to assess the effects of Rosiglitazone on TGFβ-induced αSMA expression. Topical application of Rosiglitazone to cat eyes after injury decreased αSMA expression and haze, as well as the induction of lower-order and residual, higher-order wavefront aberrations compared to vehicle-treated eyes. Rosiglitazone also inhibited TGFβ-induced αSMA expression in cultured corneal fibroblasts. In conclusion, Rosiglitazone effectively controlled corneal fibrosis in vivo and in vitro, while restoring corneal thickness and optics. Its topical application may represent an effective, new avenue for the prevention of corneal scarring with distinct advantages for pathologically thin corneas. PMID:23940641

Media depictions of health topics: challenge and stigma formats.

PubMed

Smith, Rachel

2007-01-01

This article explored the notion that media depictions of health concerns come in one of two formats: challenge and stigma. After explicating the five features that should appear in challenge format and the seven features of stigma formats, we analyzed the content of health messages in magazines, brochures, and posters (n = 75) in a metropolitan area. The results of a two-factor confirmatory factor model showed that the five suggested features for challenge formats did, indeed, appear together (alpha = .76), and the seven features for stigma formats, also, appeared together (alpha = .90), and showed no residual relationship. In other words, the results suggest that media depictions of health topics appear in either challenge or stigma formats (r = - .87). Health issues appearing in magazine advertisements and articles presented messages in challenge formats, while brochures and posters from largely nonprofit and government groups depicted health issues in stigma formats. Some health topics appeared most often in challenge formats (including cancer, heart disease, and scoliosis), while others appeared in stigma formats (including tuberculosis, hepatitis, smoking, and sexually transmitted diseases [STDs]). Findings suggest that media depictions of health differ, and the implications of stigma and challenge formats are discussed.

45 CFR Appendix A to Part 650 - Optional Format for Confirmatory License

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Optional Format for Confirmatory License A Appendix A to Part 650 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... National Science Foundation, an irrevocable, nonexclusive, nontransferable, royalty-free license to...

Difficult to control atopic dermatitis

PubMed Central

2013-01-01

Difficult to control atopic dermatitis (AD) presents a therapeutic challenge and often requires combinations of topical and systemic treatment. Anti-inflammatory treatment of severe AD most commonly includes topical glucocorticosteroids and topical calcineurin antagonists used for exacerbation management and more recently for proactive therapy in selected cases. Topical corticosteroids remain the mainstay of therapy, the topical calcineurin inhibitors tacrolimus and pimecrolimus are preferred in certain locations. Systemic anti-inflammatory treatment is an option for severe refractory cases. Microbial colonization and superinfection contribute to disease exacerbation and thus justify additional antimicrobial / antiseptic treatment. Systemic antihistamines (H1) may relieve pruritus but do not have sufficient effect on eczema. Adjuvant therapy includes UV irradiation preferably of UVA1 wavelength. “Eczema school” educational programs have been proven to be helpful. PMID:23663504

Establishing Teacher Competencies in Early Care and Education: A Review of Current Models and Options for California. Building California's Preschool for All Workforce. A Series of Policy Briefs

ERIC Educational Resources Information Center

Bellm, Dan

2005-01-01

This policy brief provides guidelines grouped into five areas: personal and professional behavior; classroom environment; health, safety and nutrition; working with families and communities; and administration and management. The document discusses the topics that teacher competencies generally cover, options for how they might be developed and…

Having Many Choice Options Seems Like a Great Idea, but...: Student Perceptions about the Level of Choice for a Project Topic in a Marketing Course

ERIC Educational Resources Information Center

Ackerman, David S.; Gross, Barbara L.; Sawhney Celly, Kirti

2014-01-01

Many educators today emphasize student engagement and self-regulated learning, including giving students choices. However, research suggests that too much choice can have negative consequences such as feelings of stress and regret. An experimental design wherein students were offered different numbers of choice options when previewing, as in a…

Responsibility, guilt, and decision under risk.

PubMed

Mancini, Francesco; Gangemi, Amelia

2003-12-01

We hypothesize that individuals' choices (risk-seeking/risk-aversion) depend on moral values and, in particular, on how subjects evaluate themselves as guilty or as victims of a wrong rather than on the descriptions of the outcomes as given in the options and evaluated accordingly as gains or losses (framing effect). People who evaluate themselves as victims are expected to show a risk-seeking preference (context of innocence). People who evaluate themselves as guilty are expected to show a risk-averse preference (context of guilt). Responses of 232 participants to a decision problem were compared in four different conditions involving two-story formats (innocence/guilt) and two-question-options formats (gain/loss). Regardless of the format of the question options, the story format appears to be an important determinant of individuals' preferences.

Computer program documentation: CYBER to Univac binary conversion user's guide

NASA Technical Reports Server (NTRS)

Martin, E. W.

1980-01-01

A user's guide for a computer program which will convert SINDA temperature history data from CDC (Cyber) binary format to UNIVAC 1100 binary format is presented. The various options available, the required input, the optional output, file assignments, and the restrictions of the program are discussed.

Test-Enhanced Learning in an Immunology and Infectious Disease Medicinal Chemistry/Pharmacology Course.

PubMed

Hernick, Marcy

2015-09-25

Objective. To develop a series of active-learning modules that would improve pharmacy students' performance on summative assessments. Design. A series of optional online active-learning modules containing questions with multiple formats for topics in a first-year (P1) course was created using a test-enhanced learning approach. A subset of module questions was modified and included on summative assessments. Assessment. Student performance on module questions improved with repeated attempts and was predictive of student performance on summative assessments. Performance on examination questions was higher for students with access to modules than for those without access to modules. Module use appeared to have the most impact on low performing students. Conclusion. Test-enhanced learning modules with immediate feedback provide pharmacy students with a learning tool that improves student performance on summative assessments and also may improve metacognitive and test-taking skills.

Test-Enhanced Learning in an Immunology and Infectious Disease Medicinal Chemistry/Pharmacology Course

PubMed Central

2015-01-01

Objective. To develop a series of active-learning modules that would improve pharmacy students’ performance on summative assessments. Design. A series of optional online active-learning modules containing questions with multiple formats for topics in a first-year (P1) course was created using a test-enhanced learning approach. A subset of module questions was modified and included on summative assessments. Assessment. Student performance on module questions improved with repeated attempts and was predictive of student performance on summative assessments. Performance on examination questions was higher for students with access to modules than for those without access to modules. Module use appeared to have the most impact on low performing students. Conclusion. Test-enhanced learning modules with immediate feedback provide pharmacy students with a learning tool that improves student performance on summative assessments and also may improve metacognitive and test-taking skills. PMID:27168610

Successful treatment of bullous lichen planus with acitretin monotherapy. Review of treatment options for bullous lichen planus and case report.

PubMed

Rallis, Efstathios; Liakopoulou, Angeliki; Christodoulopoulos, Constantinos; Katoulis, Alexandros

2016-12-31

Bullous lichen planus (BLP) is a rare variant of lichen planus, characterized by the development of vesicular and bullous lesions, of skin, nails, hair and/or mucosa. We present a case of 63-year-old woman with BLP, unresponsive to previous therapies with topical corticosteroids, topical calcipotriol, antihistamines and oral cyclosporine (4 mg/kg/day for 4 months). She was already receiving treatment for arterial hypertension, hyperlipidemia, atrial fibrillation and uncontrolled diabetes mellitus. Acitretin was administered for 5 months with complete remission of BLP lesions and no major side effects. This is probably the first reported case of BLP treated with acitretin monotherapy. In this case acitretin was an efficacious and well-tolerated therapeutic option for BLP.

Strategic Model for Future Geospatial Education.

DTIC Science & Technology

1998-05-18

There appears to be only one benefit to doing nothing as option one dictates-there are no up front costs to the government for doing nothing. The costs...the government can ensure that US industry and academia benefit from decades of geospatial information expertise. Industry and academia will be...or militarily unique topics. In summary, option two provides more benefits for both the government and the geospatial information community as a

Comparison between three option, four option and five option multiple choice question tests for quality parameters: A randomized study.

PubMed

Vegada, Bhavisha; Shukla, Apexa; Khilnani, Ajeetkumar; Charan, Jaykaran; Desai, Chetna

2016-01-01

Most of the academic teachers use four or five options per item of multiple choice question (MCQ) test as formative and summative assessment. Optimal number of options in MCQ item is a matter of considerable debate among academic teachers of various educational fields. There is a scarcity of the published literature regarding the optimum number of option in each item of MCQ in the field of medical education. To compare three options, four options, and five options MCQs test for the quality parameters - reliability, validity, item analysis, distracter analysis, and time analysis. Participants were 3 rd semester M.B.B.S. students. Students were divided randomly into three groups. Each group was given one set of MCQ test out of three options, four options, and five option randomly. Following the marking of the multiple choice tests, the participants' option selections were analyzed and comparisons were conducted of the mean marks, mean time, validity, reliability and facility value, discrimination index, point biserial value, distracter analysis of three different option formats. Students score more ( P = 0.000) and took less time ( P = 0.009) for the completion of three options as compared to four options and five options groups. Facility value was more ( P = 0.004) in three options group as compared to four and five options groups. There was no significant difference between three groups for the validity, reliability, and item discrimination. Nonfunctioning distracters were more in the four and five options group as compared to three option group. Assessment based on three option MCQs is can be preferred over four option and five option MCQs.

Consensus recommendations for managing osteoarthritic pain with topical NSAIDs in Asia-Pacific.

PubMed

Rafanan, Bonifacio S; Valdecañas, Benedict F; Lim, Boon Ping; Malairungsakul, Anan; Tassanawipas, Warat; Shiyi, Chen; Tse, Lung Fung; Luong, Tuan Khanh

2018-03-01

Osteoarthritis prevalence is expected to increase markedly in the Asia-Pacific region due to rapid population aging. Identifying effective and safe therapeutic options to manage osteoarthritic pain is viewed as a priority. The Asia-Pacific Experts on Topical Analgesics Advisory Board developed consensus statements for use of topical NSAIDs in musculoskeletal pain. Evidence supporting these statements in osteoarthritic pain was reviewed. Best available evidence indicates that topical NSAIDs have a moderate effect on relief of osteoarthritic pain, comparable to that of oral NSAIDs but with a better risk-to-benefit ratio. International clinical practice guidelines recommend topical NSAIDs on par with or ahead of oral NSAIDs for pain management in patients with knee and hand osteoarthritis, and as the first-line choice in persons aged ≥75 years.

Medical student web-based formative assessment tool for renal pathology.

PubMed

Bijol, Vanesa; Byrne-Dugan, Cathryn J; Hoenig, Melanie P

2015-01-01

Background Web-based formative assessment tools have become widely recognized in medical education as valuable resources for self-directed learning. Objectives To explore the educational value of formative assessment using online quizzes for kidney pathology learning in our renal pathophysiology course. Methods Students were given unrestricted and optional access to quizzes. Performance on quizzed and non-quizzed materials of those who used ('quizzers') and did not use the tool ('non-quizzers') was compared. Frequency of tool usage was analyzed and satisfaction surveys were utilized at the end of the course. Results In total, 82.6% of the students used quizzes. The greatest usage was observed on the day before the final exam. Students repeated interactive and more challenging quizzes more often. Average means between final exam scores for quizzed and unrelated materials were almost equal for 'quizzers' and 'non-quizzers', but 'quizzers' performed statistically better than 'non-quizzers' on both, quizzed (p=0.001) and non-quizzed (p=0.024) topics. In total, 89% of surveyed students thought quizzes improved their learning experience in this course. Conclusions Our new computer-assisted learning tool is popular, and although its use can predict the final exam outcome, it does not provide strong evidence for direct improvement in academic performance. Students who chose to use quizzes did well on all aspects of the final exam and most commonly used quizzes to practice for final exam. Our efforts to revitalize the course material and promote learning by adding interactive online formative assessments improved students' learning experience overall.

Star Formation and Exoplanetary Systems in the National Science Olympiad Astronomy Event for High School Students

NASA Astrophysics Data System (ADS)

Komacek, Thaddeus D.; Young, Donna; Schroeder, Dustin M.; Van Hecke, Mark A.

2014-11-01

Science Olympiad is one of the nation’s largest secondary school science competitions, reaching over 240,000 students on more than 6,000 teams. The competition covers various aspects of science and technology, exposing students to a variety of career options in STEM. 9 of Science Olympiad’s 46 events (with 23 for both middle and high school) have a focus on Earth and Space Science, including process skills and knowledge of a variety of subjects, including: Astrophysics, Planetary Sciences, Oceanography, Meteorology, Remote Sensing, and Geologic Mapping, among others. The Astronomy event is held for students from 9th - 12th grade, and covers topics based upon stellar evolution and/or galactic astronomy. For the 2014-2015 competition season, Astronomy will focus on star formation and exoplanets in concert with stellar evolution, bringing recent and groundbreaking research to light for young potential astronomers and planetary scientists. The event tests students on their “understanding of the basic concepts of mathematics and physics relating to stellar evolution and star and planet formation,” including qualitative responses, DS9 image analysis, and quantitative problem solving. We invite any members of the exoplanet and star formation communities that are interested in developing event materials to contact the National event supervisors, Donna Young (donna@aavso.org) and Tad Komacek (tkomacek@lpl.arizona.edu). We also encourage you to contact your local regional or state Science Olympiad tournament directors to help supervise events and run competitions in your area.

Astrophysical Magnetic Fields and Topics in Galaxy Formation

NASA Technical Reports Server (NTRS)

Field, George B.

1997-01-01

The grant was used to support theoretical research on a variety of astro-physical topics falling broadly into those described by the proposal: galaxy formation, astrophysical magnetic fields, magnetized accretion disks in AGN, new physics, and other astrophysical problems. Work accomplished; references are to work authored by project personel.

Gluten-Free Labeling of Foods

MedlinePlus

... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Food Home Food Guidance & Regulation Guidance Documents & Regulatory Information by Topic Allergens Gluten-Free Labeling of Foods Share Tweet Linkedin Pin it More sharing options ...

How to Lower Cholesterol: MedlinePlus Health Topic

MedlinePlus

... a non-statin cholesterol-lowering treatment option. ... Medicines Heart Diseases High Cholesterol in Children and Teens How to Lower Cholesterol with Diet Quitting Smoking Statins Weight Control National Institutes of ...

An overview of pharmacotherapy in premature ejaculation.

PubMed

Porst, Hartmut

2011-10-01

With increasing interest and clinical research in male sexual disorders, it has become clear that not only psychological but also organic, neurobiological, and genetic factors may play an important role in premature ejaculation (PE). This article provides an overview of the different treatment options both for lifelong (primary, "congenital") and acquired (secondary) PE. Review of the literature. Currently used treatment options for PE. Treatments reviewed include psychological/behavioral/sexual counseling therapy, topical anesthetics, dapoxetine, and other selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and phosphodiesterase-5 (PDE-5) inhibitors. Before starting any therapy for PE, correct diagnosis has to be made considering the patient's reported intravaginal ejaculatory latency time (IELT) and the duration and type of PE. Concomitant erectile dysfunction (ED) should be either ruled out or proven by appropriate means. In uncomplicated cases of PE with stable partnerships, medical treatment represents the first-choice option with a high likelihood of success. Dapoxetine, where available, or other SSRIs provide suitable therapeutic options with a good risk/benefit profile for patients. In complicated ("difficult-to-treat") PE patients, a combination of medication and sexual counseling should be considered the first treatment option. Combination therapies of PDE-5 inhibitors and PE-related medications should be offered to patients suffering from comorbid PE and ED, with ED treatment starting first. In those patients with severe PE-IELTs of <30-60 seconds or anteportal ejaculation-combination therapy of topical and oral medications can be offered and may considerably increase IELT, compared with either monotherapy. 2011 International Society for Sexual Medicine.

[Keloid scars of the external ear: a non solved problem].

PubMed

Bejarano Serrano, M; Parri Ferrandis, F J; García Smith, N I; Martínez-Herrada, S; Manzanares Quintela, A; Albert Cazalla, A

2014-01-01

The external ear is a location with high risk of keloid scar formation. Its incidence is growing since general use of piercings and performance of plastic surgery of the external ear. The external ear keloid can be a devasting process for adolescent population which is worried about their appearance. Our aim is to attract attention about the risk of keloid scars of the external ear, reviewing our experience. After dismissing radiotherapy, corticoid infiltration and surgical removal are the most used options, with a high recurrence risk. We have reviewed traumatic, surgical and piercing wounds of the external ear, with a subsequent keloid formation treated in our outpatient clinic, collecting data about wound etiology, treatment and results. During the last 10 years we have found 11 keloid scars, 2 of them improved with topical corticosteroid. Treatment has been surgical in 9 cases, 4 of them with skin graft: 5 recovered and 4 recurred; 2 of them were reoperated. 2 of them were treated with intralesional corticosteroid solely, one recovered and the other one had improved. Treatment management of keloid scars is complex and there isn't a procedure with superior results than the others. Risk of complication must be explained within adolescent population.

The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 2 Core.

PubMed

Hucka, Michael; Bergmann, Frank T; Dräger, Andreas; Hoops, Stefan; Keating, Sarah M; Le Novère, Nicolas; Myers, Chris J; Olivier, Brett G; Sahle, Sven; Schaff, James C; Smith, Lucian P; Waltemath, Dagmar; Wilkinson, Darren J

2018-03-09

Computational models can help researchers to interpret data, understand biological functions, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that different software systems can exchange. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 2 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML, their encoding in XML (the eXtensible Markup Language), validation rules that determine the validity of an SBML document, and examples of models in SBML form. The design of Version 2 differs from Version 1 principally in allowing new MathML constructs, making more child elements optional, and adding identifiers to all SBML elements instead of only selected elements. Other materials and software are available from the SBML project website at http://sbml.org/.

Systemic and topical drugs for aging skin.

PubMed

Kockaert, Michael; Neumann, Martino

2003-08-01

The rejuvenation of aging skin is a common desire for our patients, and several options are available. Although there are some systemic methods, the most commonly used treatments for rejuvenation of the skin are applied topically. The most frequently used topical drugs include retinoids, alpha hydroxy acids (AHAs), vitamin C, beta hydroxy acids, anti-oxidants, and tocopherol. Combination therapy is frequently used; particularly common is the combination of retinoids and AHAs. Systemic therapies available include oral retinoids and vitamin C. Other available therapies such as chemical peels, face-lifts, collagen, and botulinum toxin injections are not discussed in this article.

Successful treatment of plasma cell cheilitis with topical tacrolimus: report of two cases.

PubMed

Hanami, Yuka; Motoki, Yoshikazu; Yamamoto, Toshiyuki

2011-02-15

Plasma cell cheilitis is an uncommon chronic inflammatory dermatitis that presents with flat to slightly elevated erosive erythematous plaques. It is histologically characterized by plasma cell infiltrates into the mucosa. Other than the lip, genital areas are often involved, which is called plasma cell balanitis or vulvitis. Plasma cell cheilitis is sometimes resistant to conventional topical corticosteroid therapy. Other choices include oral griseofulvin, topical cyclosporine, and intralesional corticosteroid injection, all of which occasionally fail to produce satisfactory results. Recent reports show that topical calcineurin inhibitors are effective for plasma cell cheilitis, balanitis, and vulvitis. However, there are so far only 2 reports of plasma cell cheilitis successfully treated with topical pimecrolimus and tacrolimus. We present herein two cases of plasma cell cheilitis, in which topical tacrolimus showed beneficial effects, suggesting that this immunomodulatory agent is a promising option for plasma cell cheilitis.

Protective effect of Fucoxanthin against UVB-induced skin photoaging in hairless mice.

PubMed

Urikura, Itaru; Sugawara, Tatsuya; Hirata, Takashi

2011-01-01

Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects.

NASA Exploration Team (NExT) In-Space Transportation Overview

NASA Technical Reports Server (NTRS)

Drake, Bret G.; Cooke, Douglas R.; Kos, Larry D.; Brady, Hugh J. (Technical Monitor)

2002-01-01

This presentation provides an overview of NASA Exploration Team's (NEXT) vision of in-space transportation in the future. Hurdles facing in-space transportation include affordable power sources, crew health and safety, optimized robotic and human operations and space systems performance. Topics covered include: exploration of Earth's neighborhood, Earth's neighborhood architecture and elements, Mars mission trajectory options, delta-v variations, Mars mission duration options, Mars mission architecture, nuclear electric propulsion advantages and miscellaneous technology needs.

The Evolving Role of Regional Radiation Oncology Societies in Resident Education.

PubMed

Mattes, Malcolm D

2015-09-01

The goal of this study is to develop insight into how a regional radiation oncology organization like the New York Roentgen Society (NYRS) can best assist in the education and development of residents. From April to June 2012, an electronic survey was sent to all 41 post-graduate year 2-4 radiation oncology residents in the New York metropolitan area. Questions were formatted using Likert scales (ranging from 1 to 5), and the Friedman and Wilcoxon signed-rank tests were used to compare the mean ratings of each answer option. Surveys were completed by 34 residents (response rate 83 %). The three highest rated features that residents hope to get out of their membership in the NYRS included "networking" (mean 4.21), "career mentoring" (mean 4.18), and "education" (mean 4.15), all of which were rated significantly higher (p < 0.002) than the lowest rated "physics boards review" (mean 3.36) and "radiation biology boards review" (mean 3.15). The three highest rated types of subject matter for meetings included "boards review" (mean 4.03), "debate on a controversial clinical topic" (mean 3.97), and a "career mentoring workshop" (mean 3.93), all of which were rated significantly higher (p < 0.001) than the lowest rated "lecture on a research topic" (mean 2.40) and "lecture on a radiation biology/physics topic" (mean 2.07). Residents favor networking, career mentoring, and clinical educational content (particularly as it relates to boards review) from their regional radiation oncology society. These findings may be applicable to similar organizations in other cities, as a guide for future programming.

Rhinophyma Treated with Options Today

MedlinePlus

... Measures Help Reduce Flare-Ups, Survey Shows › Rosacea Review Current Issue Past Issues Index by Topic Glossary ... Works for Me: Patient Tips Physician Finder Rosacea Review Newsletter Seborrhea Rosacea Awareness Month Understanding Rosacea Brochure ...

Proceedings: Wildland Shrub and Arid Land Restoration Symposium

Treesearch

Bruce A. Roundy; E. Durant McArthur; Jennifer S. Haley; David K. Mann

1995-01-01

Includes 62 papers dealing with wildland shrubs and restoration of arid lands. The key topics include: overview, restoration and revegetation, ecology, genetic integrity, management options, and field trip.Individual papers from this publication

Vulvar Cancer Treatment (PDQ®)—Health Professional Version

Cancer.gov

Vulvar cancer treatment options include a variety of surgical procedures, topical imiquimod, radiation therapy, chemotherapy, and chemoradiation. Get detailed treatment information for newly diagnosed and recurrent vulvar cancer in this summary for clinicians.

Communicating asset risk: how name recognition and the format of historic volatility information affect risk perception and investment decisions.

PubMed

Weber, Elke U; Siebenmorgen, Niklas; Weber, Martin

2005-06-01

An experiment examined how the type and presentation format of information about investment options affected investors' expectations about asset risk, returns, and volatility and how these expectations related to asset choice. Respondents were provided with the names of 16 domestic and foreign investment options, with 10-year historical return information for these options, or with both. Historical returns were presented either as a bar graph of returns per year or as a continuous density distribution. Provision of asset names allowed for the investigation of the mechanisms underlying the home bias in investment choice and other asset familiarity effects. Respondents provided their expectations of future returns, volatility, and expected risk, and indicated the options they would choose to invest in. Expected returns closely resembled historical expected values. Risk and volatility perceptions both varied significantly as a function of the type and format of information, but in different ways. Expected returns and perceived risk, not predicted volatility, predicted portfolio decisions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This guidebook addresses the primary requirements of the Alternative Fuel Transportation Program to help state and alternative fuel provider fleets comply with the Energy Policy Act via the Standard Compliance option. It also addresses the topics that covered fleets ask about most frequently.

Educating Information Brokers.

ERIC Educational Resources Information Center

Kehoe, Cynthia A.

1997-01-01

Discusses the education and training needed for information brokers. Topics include information broker as a career option; how library and information science programs can prepare students; research skills versus reference skills; small business management; and alternative and continuing education. (LRW)

Vaginal Cancer Treatment (PDQ®)—Health Professional Version

Cancer.gov

Vaginal cancer treatment options include a variety of surgical procedures, topical chemotherapy, radiation therapy, and combination radiation therapy. Get detailed treatment information for newly diagnosed and recurrent vaginal cancer in this summary for clinicians.

A guide to transportation funding options : phase 2, final report, October 2009.

DOT National Transportation Integrated Search

2009-10-01

This project is a continuation of a project that provided a one-stop shop website, A Guide to Transportation Funding : Options (http://utcm.tamu.edu/tfo), detailing transportation funding options and their applicability in an easy-to-use : format. Th...

Noninvasive Drug Delivery Using Ultrasound: Targeting Melanoma Using siRNA Against Mutant (V600E) B-Raf

NASA Astrophysics Data System (ADS)

Tran, Melissa A.; Gowda, Raghavendra; Park, Eun-Joo; Adair, James; Smith, Nadine; Kester, Mark; Robertson, Gavin P.

2009-04-01

Melanoma is the most deadly form of skin cancer. Currently early surgical removal is the best treatment option for melanoma patients with little hope of successful treatment of late stage melanoma. Clearly new treatment options must be explored. Topical administration of drugs provides the advantage of being able to apply large quantities of drug in close proximity to the tumor without the issue of systemic side effects. However, the natural barrier formed by the skin must first be overcome for topical treatment to become a viable option. With this in mind we have sought to use low-frequency ultrasound to transiently permeabilize the stratum corneum and successfully deliver liposomal siRNA to melanoma cells residing at the basement membrane. B-Raf is one of the most frequently activated genes in melanoma, making it an ideal candidate for targeting via siRNA. The novel liposomes used in this study load siRNA, protect if from the outside environment and lead to knockdown of target message. Combining ultrasound with liposomal siRNA we show that siRNA can be delivered into melanoma cells. Additionally, we show that siRNA to mutant B-Raf can effectively inhibit melanoma growth in reconstructs and in mice by 60% and 30% respectively. Therefore, ultrasound with liposomal siRNA is a potentially valuable treatment option for melanoma patients.

Spacecraft formation keeping near the libration points of the Sun-Earth/Moon system

NASA Astrophysics Data System (ADS)

Marchand, Belinda G.

Multi-spacecraft formations, evolving near the vicinity of the libration points of the Sun-Earth/Moon system, have drawn increased interest for a variety of applications. This is particularly true for space based interferometry missions such as Terrestrial Planet Finder (TPF) and the Micro Arcsecond X-Ray Imaging Mission (MAXIM). Recent studies in formation flight have focused, primarily, on the control of formations that evolve in the immediate vicinity of the Earth. However, the unique dynamical structure near the libration points requires that the effectiveness and feasibility of these methods be re-examined. The present study is divided into two main topics. First, a dynamical systems approach is employed to develop a better understanding of the natural uncontrolled formation dynamics in this region of space. The focus is formations that evolve near halo orbits and Lissajous trajectories, near the L1 and L2 libration points of the Sun-Earth/Moon system. This leads to the development of a Floquet controller designed to simplify the process of identifying naturally existing formations as well as the associated stable manifolds for deployment. The initial analysis is presented in the Circular Restricted Three-Body Problem, but the results are later transitioned into the more complete Ephemeris model. The next subject of interest in this investigation is non-natural formations. That is, formations that are not consistent with the natural dynamical flow near the libration points. Mathematically, precise formation keeping of a given nominal configuration requires continuous control. Hence, a detailed analysis is presented to contrast the effectiveness and issues associated with linear optimal control and feedback linearization methods. Of course, continuous operation of the thrusters, may not represent a feasible option for a particular mission. If discrete formation keeping is implemented, however, the formation keeping goal will be subject to increased tracking errors relative to the nominal path. With this in mind, the final phase of the analysis presented here is centered on discrete formation keeping. The initial analysis is devoted to both linear state and radial targeters. The results from these two methodologies are later employed as a starting solution for an optimal impulsive control algorithm.

Dental unit water lines decontamination with the aid of nanotechnology.

PubMed

Paramashivaiah, Rashmi; Prabhuji, M L V; Narayanan, Roopalakshmi

2016-01-01

This article reviews the issue of dental unit waterline (DUWL) contamination which affects all the clinical and hospital settings. The contaminating microorganisms commonly isolated from these settings and the most pathogenic among them have serious consequences. Over the years several measures are inculcated for decontamination of water, their advantages and shortcomings have been addressed. Options using nanotechnology which are available in the market are described briefly. A manual and electronic search was conducted. Google and PubMed were searched for relevant material from studies up to 2013. Medical Subject Headings words looked for were "Nanotechnology," "Water purification," and "Biofilms." Reviewed findings were summarized by topic, using the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement for reporting. Seventy articles were shortlisted for articles pertaining to our topic of discussion. A systematic approach was followed by two independent reviewers and included eligibility criteria for study inclusion, data extraction, data synthesis, and drawing of conclusion. Dental waterline contamination is widespread in any type of dental setting having serious implications on clinicians and patients alike, especially elderly and immune-compromised. Hence, international bodies like center for disease and control and American Dental Association have come up with stringent measures for maintenance of water quality. A gamut of procedures has been tried to overcome this problem ranging from chlorinated products, water filters to the usage of distilled water. The use of nanoemulsions, nanofilters, nanomembranes, etc., and their applicability for routine usage is discussed. Biofilm formation in DUWLs is inevitable with the subsequent release of part of microbiota into the otherwise sterile dental settings. These consequences can be quite serious on clinicians and dental patients. Though conventional measures in water decontamination have been partly successful, the quest for more foolproof methods has led to the use of latest technology, i.e., nanotechnology. The most practical option has to be chosen based on the ease of their usage.

Systemic and Topical Use of Tranexamic Acid in Spinal Surgery: A Systematic Review

PubMed Central

Winter, Sebastian F.; Santaguida, Carlo; Wong, Jean; Fehlings, Michael G.

2015-01-01

Study Design Combination of narrative and systematic literature reviews. Objectives Massive perioperative blood loss in complex spinal surgery often requires blood transfusions and can negatively affect patient outcome. Systemic use of the antifibrinolytic agent tranexamic acid (TXA) has become widely used in the management of surgical bleeding. We review the clinical evidence for the use of intravenous TXA as a hemostatic agent in spinal surgery and discuss the emerging role for its complementary use as a topical agent to reduce perioperative blood loss from the surgical site. Through a systematic review of published and ongoing investigations on topical TXA for spinal surgery, we wish to make spine practitioners aware of this option and to suggest opportunities for further investigation in the field. Methods A narrative review of systemic TXA in spinal surgery and topical TXA in surgery was conducted. Furthermore, a systematic search (using PRISMA guidelines) of PubMed (MEDLINE), EMBASE, and Cochrane CENTRAL databases as well as World Health Organization International Clinical Trials Registry Platform, ClinicalTrials.gov (National Institutes of Health), and International Standard Randomized Controlled Trial Number registries was conducted to identify both published literature and ongoing clinical trials on topical TXA in spinal surgery. Results Of 1,631 preliminary search results, 2 published studies were included in the systematic review. Out of 285 ongoing clinical trials matching the search criteria, a total of 4 relevant studies were included and reviewed. Conclusion Intravenous TXA is established as an efficacious hemostatic agent in spinal surgery. Use of topical TXA in surgery suggests similar hemostatic efficacy and potentially improved safety as compared with intravenous TXA. For spinal surgery, the literature on topical TXA is sparse but promising, warranting further clinical investigation and consideration as a clinical option in cases with significant anticipated surgical site blood loss. PMID:27099820

Senioritis: Some Paths to Sanity

ERIC Educational Resources Information Center

O'Neal, Roland

1978-01-01

A social studies course for high school seniors combines a problems of democracy content with options emphasizing long-term accountability. Each student has a faculty adviser who encourages the student to pursue a specialized social studies topic. (Author/DB)

Statistical Policy Working Paper 24. Electronic Dissemination of Statistical Data

DOT National Transportation Integrated Search

1995-11-01

The report, Statistical Policy Working Paper 24, Electronic Dissemination of Statistical Data, includes several topics, such as Options and Best Uses for Different Media Operation of Electronic Dissemination Service, Customer Service Programs, Cost a...

'GRC1.5': Uptower Gearbox Testing to Investigate Bearing Axial Cracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Jonathan; Vaes, David; McNiff, Brian

2016-02-16

This presentation focuses on the investigation of bearing axial cracking using the GRC1.5 uptower gearbox. Topics covered include the testing options considered, the project goal, and current and near-term activities.

Combining Chemistry and Music to Engage Student Interest: Using Songs to Accompany Selected Chemical Topics

ERIC Educational Resources Information Center

Last, Arthur M.

2009-01-01

The use of recorded music to add interest to a variety of lecture topics is described. Topics include the periodic table, the formation of ionic compounds, thermodynamics, carbohydrates, nuclear chemistry, and qualitative analysis. (Contains 1 note.)

Intravenous Foscarnet With Topical Cidofovir for Chronic Refractory Genital Herpes in a Patient With AIDS.

PubMed

Usoro, Agnes; Batts, Alfreda; Sarria, Juan C

2015-01-01

Few case reports have documented the use of topical cidofovir for refractory genital herpes simplex virus (HSV) ulcers in human immunodeficiency virus (HIV) infected patients. This drug formulation lacks a standardized concentration or even a procedural outline as to how it should be compounded. We aim to discuss the utilization of topical cidofovir in addition to presenting a procedural means of compounding it for treatment of refractory genital HSV ulcers. Our patient completed 21 days of intravenous foscarnet and 13 days of topical cidofovir with clinical improvement in the penile and scrotal ulcers. Genital herpes is a concern in patients with HIV because it generally manifests as a persistent infection. Physicians should be aware that when patients fail to respond to the conventional treatment regimens for genital HSV in a timely manner, other options are available, such as topical cidofovir as an adjuvant to systemic antivirals.

[CANNABIS AND GLAUCOMA: AN ANCIENT LEGEND OR A NOVEL THERAPEUTIC HORIZON?].

PubMed

Mathalone, Nurit; Wolf, Alvit; Geyer, Orna

2015-06-01

Glaucoma causes damage to the optic nerve and compromises the visual field. The main risk factor of the disease is the level of the intra-ocular pressure. Therapeutic options include medical and surgical treatment, aimed to lower the intra-ocular pressure. Consumption of the cannabis plant (Cannabis Satival has been known since ancient times. It can be consumed orally, topically, intra-venous or by inhalation. The main active ingredient of cannabis is THC (Tetra-Hydro-Cannabinol). One of THC's reported effects is the reduction of intra-ocular pressure. Several studies have demonstrated temporary intra-ocular pressure decrease in both healthy subjects and glaucoma patients following topical application or systemic consumption. The effect was a short term one. It was followed by the development of resistance to the drug after prolonged intake and it was also accompanied by topical and systemic side effects. Cannabis may be considered as a therapeutic option in glaucoma. Its limited effect, development of resistance, acquired side effects and the accompanying psycho-active influence limit its advantage and cause its efficacy to be dubious. Therefore, cannabis treatment for glaucoma currently seems impractical and is not recommended by either the Israeli or the American glaucoma societies.

Ultraviolet B Phototherapy for Psoriasis: Review of Practical Guidelines.

PubMed

Mehta, Dhwani; Lim, Henry W

2016-04-01

Psoriasis is an inflammatory skin condition that affects approximately 2 % of people worldwide. Topical treatments, systemic treatments, biologic agents, and phototherapy are all treatment options for psoriasis. Ultraviolet (UV) B phototherapy is most appropriate for patients with >10 % affected body surface area who have not responded to topical treatments. This review outlines the use, dosage, safety, and efficacy of narrowband UVB (NB-UVB) and targeted phototherapy. NB-UVB and excimer laser are effective treatment options for psoriasis; they are administered two to three times weekly until clearance followed by maintenance treatment before discontinuation. Long-term data on NB-UVB indicate that it has a good safety profile. NB-UVB is commonly used with adjunctive topical treatments such as emollients, calcipotriene, cortico-steroids, retinoids, and tar. NB-UVB can be used in selected patients with traditional systemic agents such as methotrexate, mycophenolate mofetil, and cyclosporine, although the duration of the combined treatment should be kept to a minimum and patients need to be closely monitored. Acitretin can be safely used with phototherapy, but robust data on the combination use of biologic agents or phosphodiesterase inhibitors with phototherapy are lacking.

Treatment of Annular Elastolytic Giant Cell Granuloma With Topical Tretinoin.

PubMed

Wagenseller, Aubrey; Larocca, Cecilia; Vashi, Neelam A

2017-07-01

Annular elastolytic giant cell granuloma, also known as actinic granuloma, is a rare skin condition with a chronic course that is often resistant to treatment. Literature is sparse, and only a handful of case reports are available to guide treatment decisions. Typical first line treatment options include topical and intralesional steroids, topical pimecrolimus, and cryotherapy. Resistant cases have been treated with cyclosporine, systemic steroids, antimalarials, and oral retinoids. In particular, acitretin and isotretinoin have shown success in three cases. However, these medications can have side effects and require frequent lab monitoring. We present a case of a 47-year-old woman with bilateral forearm lesions consistent with annular elastolytic giant cell granuloma who was successfully treated with topical tretinoin.

J Drugs Dermatol. 2017;16(7):699-700.

The Differences among Three-, Four-, and Five-Option-Item Formats in the Context of a High-Stakes English-Language Listening Test

ERIC Educational Resources Information Center

Lee, HyeSun; Winke, Paula

2013-01-01

We adapted three practice College Scholastic Ability Tests (CSAT) of English listening, each with five-option items, to create four- and three-option versions by asking 73 Korean speakers or learners of English to eliminate the least plausible options in two rounds. Two hundred and sixty-four Korean high school English-language learners formed…

Biobrane versus topical agents in the treatment of adult scald burns.

PubMed

Krezdorn, Nicco; Könneker, Sören; Paprottka, Felix Julian; Tapking, Christian; Mett, Tobias R; Brölsch, G Felix; Boyce, Maria; Ipaktchi, Ramin; Vogt, Peter M

2017-02-01

Limited data is available for treatment of scald lesions in adults. The use of the biosynthetic matrix Biobrane ® has been suggested as treatment option with more benefits over topical dressings. Application of Biobrane ® in scalds in our center led to a perceived increase of infection, secondary deepening, surgery and length of stay. We therefore assessed the effect of different treatment options in adult scalds in our center. We performed a retrospective cohort study of adult patients that have been admitted with scalds in our center between 2011 and 2014. We assessed two groups, group 1 with Biobrane ® as initial treatment and group 2 with topical treatment using polyhexanid hydrogel and fatty gauze. Primary outcome variables were rate of secondary deepening, surgery, infection (defined as positive microbiological swabs and antibiotic treatment) and length of stay. Total body surface area (TBSA) as well as diabetes mellitus (DM), hypertension, smoking and alcohol consumption as potential confounders were included. A total of 52 patients were included in this study. 36 patients received treatment with Biobrane ® and 16 with ointment and fatty gauze. No significant differences were found for age and TBSA whereas gender ratio was different (25/11 male/female in group 1 vs 4/12 in group 2, p=0.003). Rate of secondary deepening, surgery, infection as well as days of hospital stay (DOHS) were comparable. Logistic and multilinear regression showed TBSA to be a predictive factor for infection (p=0.041), and TBSA and age for length of stay (age p=0.036; TBSA p=0.042) in group 1. The use of Biobrane ® in adult scald lesions is safe and non-inferior to topical treatment options. In elder patients and larger TBSA Biobrane ® may increase the risk of infection or a prolonged stay in hospital. Level 3 - retrospective cohort study. Copyright © 2016 Elsevier Ltd and ISBI. All rights reserved.

Energy Options for the Future

NASA Astrophysics Data System (ADS)

Sheffield, John; Obenschain, Stephen; Conover, David; Bajura, Rita; Greene, David; Brown, Marilyn; Boes, Eldon; McCarthy, Kathyrn; Christian, David; Dean, Stephen; Kulcinski, Gerald; Denholm, P. L.

2004-06-01

This paper summarizes the presentations and discussion at the Energy Options for the Future meeting held at the Naval Research Laboratory in March of 2004. The presentations covered the present status and future potential for coal, oil, natural gas, nuclear, wind, solar, geothermal, and biomass energy sources and the effect of measures for energy conservation. The longevity of current major energy sources, means for resolving or mitigating environmental issues, and the role to be played by yet to be deployed sources, like fusion, were major topics of presentation and discussion.

Technical Options for Energy Conservation in Buildings. National Conference of States on Building Codes and Standards and National Bureau of Standards Joint Emergency Workshop on Energy Conservation in Buildings. (Washington, D.C., June 19, 1973) NBS Technical Note 789.

ERIC Educational Resources Information Center

National Bureau of Standards (DOC), Washington, DC. Inst. for Applied Technology.

The purpose of this report is to provide reference material on the technical options for energy conservation in buildings. Actions pertinent to existing buildings and new buildings are considered separately. Regarding existing buildings, principal topics include summer cooling, winter heating, and other energy-related features such as insulation,…

Topical Microbicides and HIV Prevention in the Female Genital Tract

PubMed Central

Cottrell, Mackenzie L; Kashuba, Angela D. M.

2014-01-01

Worldwide, HIV disproportionately affects women who are often unable to negotiate traditional HIV preventive strategies such as condoms. In the absence of an effective vaccine or cure, chemoprophylaxis may be a valuable self-initiated alternative. Topical microbicides have been investigated as one such option. The first generation topical microbicides were non-specific, broad-spectrum antimicrobial agents, including surfactants, polyanions, and acid buffering gels, that generally exhibited contraceptive properties. After extensive clinical study, none prevented HIV infection, and their development was abandoned. Second generation topical microbicides include agents with selective mechanisms of antiviral activity. Most are currently being used for, or have previously been explored as, drugs for treatment of HIV. The most advanced of these is tenofovir 1% gel: the first topical agent shown to significantly reduce HIV infection by 39% compared to placebo. This review summarizes the evolution of topical microbicides for HIV chemoprophylaxis, highlights important concepts learned, and offers current and future considerations for this area of research. PMID:24664786

To Show or Not to Show: The Effects of Item Stems and Answer Options on Performance on a Multiple-Choice Listening Comprehension Test

ERIC Educational Resources Information Center

Yanagawa, Kozo; Green, Anthony

2008-01-01

The purpose of this study is to examine whether the choice between three multiple-choice listening comprehension test formats results in any difference in listening comprehension test performance. The three formats entail (a) allowing test takers to preview both the question stem and answer options prior to listening; (b) allowing test takers to…

Topical treatment of melasma.

PubMed

Bandyopadhyay, Debabrata

2009-01-01

Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.

Teaching reproductive options through the use of fiction: the Cider House Rules project.

PubMed

Engstrom, Janet L; Hunter, Ramona G

2007-01-01

Alternative teaching strategies such as storytelling and the critical reading of literature are thought to help students develop their critical thinking, emotional intelligence, and cultural sensitivity and thereby better understand the context in which their patients live and make decisions. Such teaching methods are ideally suited for examining morally complex issues such as reproductive options. This article describes an alternative approach to teaching the complex personal, social, and moral issues surrounding the topic of reproductive options. The critical reading of the book, The Cider House Rules, provides a unique opportunity for students to obtain insight and understanding of the complex circumstances under which women and their families make reproductive decisions.

A Volcano Rekindled: The Renewed Eruption of Mount St. Helens, 2004-2006

USGS Publications Warehouse

Sherrod, David R.; Scott, William E.; Stauffer, Peter H.

2008-01-01

Mount St. Helens began a dome-building eruption in September 2004 after nearly two decades of quiescence. Dome growth was initially robust, became more sluggish with time, and ceased completely in late January 2008. The volcano has been quiet again since January 2008. Professional Paper 1750 describes the first 1 1/2 years of this eruptive activity, chiefly from September 2004 until December 2005. Its 37 chapters contain contributions of 87 authors from 23 institutions, including the U.S. Geological Survey, Forest Service, many universities, and local and State emergency management agencies. Chapter topics range widely - from seismology, geology, geodesy, gas geochemistry, and petrology to the human endeavor required for managing the public volcanic lands and distributing information during the hectic early days of a renewed eruption. In PDF format, the book may be downloaded in its entirety or by its topical sections, each section including a few prefatory paragraphs that describe the general findings, recurrent themes, and, in some cases, the unanswered questions that arise repeatedly. Those readers who prefer downloading the smaller files of only a chapter or two have this option available as well. Readers are directed to chapter 1 for a general overview of the eruption and the manner in which different chapters build our knowledge of events. More detailed summaries for specific topics can be found in chapter 2 (seismology), chapter 9 (geology), chapter 14 (deformation), chapter 26 (gas geochemistry), and chapter 30 (petrology). The printed version of the book may be purchased as a hardback weighty tome (856 printed pages) that includes a DVD replete with the complete online version, including all chapters and several additional appendixes not in the printed book.

Urban adolescent high-risk sexual behavior: corroboration of focus group discussions through pile-sorting. The AIDS Youth Research Team.

PubMed

Stanton, B F; Aronson, R; Borgatti, S; Galbraith, J; Feigelman, S

1993-01-01

Risk activities for acquisition of the human immunodeficiency virus (HIV) remain prevalent among urban adolescents. While interdisciplinary approaches to examine the variables contributing to risk/protective behaviors have been promoted, strategies for such explorations require further formulation. Recently we employed focus group discussions to explore factors placing urban adolescents at risk for engaging in HIV risk behaviors. The focus group format enables substantial interaction on a topic in a limited time period, but does not always provide expression of the full range of behavioral options. In this study we investigated the use of pile-sorts for confirmation of impressions from focus group discussions among 57 urban youths aged 10-14. The pile-sorts revealed some support for most of the views expressed in the group discussions. However, the sorts revealed more variability in views than was expressed in the group discussions. Substantial gender and age-based differences in perceptions were revealed with potentially important intervention implications.

Therapeutic options to treat sulfur mustard poisoning--the road ahead.

PubMed

Smith, William J

2009-09-01

For the past 15 years the international research community has conducted a basic and applied research program aimed at identifying a medical countermeasure against chemical threat vesicant, or blistering, agents. The primary emphasis of this program has been the development of therapeutic protection against sulfur mustard and its cutaneous pathology-blister formation. In addition to the work on a medical countermeasures, significant research has been conducted on the development of topical skin protectants and medical strategies for wound healing. This review will focus on the pharmacological strategies investigated, novel therapeutic targets currently under investigation and therapeutic approaches being considered for transition to advanced development. Additionally, we will review the expansion of our understanding of the pathophysiological mechanisms of mustard injury that has come from this research. While great strides have been made through these investigations, the complexity of the mustard insult demands that further studies extend the inroads made and point the way toward better understanding of cellular and tissue disruptions caused by sulfur mustard.

How to improve your PubMed/MEDLINE searches: 2. display settings, complex search queries and topic searching.

PubMed

Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

2014-01-01

The way that PubMed results are displayed can be changed using the Display Settings drop-down menu in the result screen. There are three groups of options: Format, Items per page and Sort by, which allow a good deal of control. The results from several searches can be temporarily stored on the Clipboard. Records of interest can be selected on the results page using check boxes and can then be combined, for example to form a reference list. The Related Citations is a valuable feature of PubMed that can provide a set of similar articles when you have identified a record of interest among the results. You can easily search for RCTs or reviews using the appropriate filters or field tags. If you are interested in clinical articles, rather than basic science or health service research, then the Clinical Queries tool on the PubMed home page can be used to retrieve them.

IT Research Services: Powerful Tools to Track a Fast Moving Industry

NASA Technical Reports Server (NTRS)

Hunter, Paul

2010-01-01

Research services change and evolve over time, sometimes suddenly, in their focus, topics, formats, service model, etc. You have to check in often. Some offer products that you can customize to your environment, others not so much. You will find a variation in customer management practices (e.g., when and how they share information) ...can sometimes be annoying. Assess your needs carefully. Each research service has a very different service model. Explore ways to share or lower the cost. Someone out there may share the expense when that is an option. Make sure you read the small print. It can work for you as well as against you. When in doubt, ask your Vendor's POC. Set up Research Service "gurus or SME's." Not to violate the copyright agreement of course, just have someone who knows what's there. After you subscribe, reassess.Get the most out of your investment. Some early enthusiasts will fade, and there will be others who don't know it's there and can use it.

Teaching Electrostatics in University Courses

ERIC Educational Resources Information Center

Hughes, J. F.

1974-01-01

Describes an optional course on applied electrostatics that was offered to electrical engineers in their final year. Topics included the determination of electric fields, nature of the charging process, static electricity in liquids, solid state processes, charged particle applications, and electrostatic ignition. (GS)

Downsizing: Fat Reduction or Fool's Gold?

ERIC Educational Resources Information Center

Teece, Phil

1999-01-01

Discussion of downsizing in organizations focuses on Australian libraries. Topics include rationales behind downsizing; negative results in terms of equity and efficiency; guidelines and other options for responsible restructuring, including skills training, continuous learning programs, information sharing, and employee participation; jobs for…

Micros for the 1990's: An Update.

ERIC Educational Resources Information Center

Grosch, Audrey N.

1991-01-01

Discusses new hardware and software developments for microcomputers and considers strategies for future library microcomputing. Topics discussed include developments with Macintosh computers; the importance of local area networks (LANs); upgrading options for hardware; operating system upgrades; dynamic data exchange (DDE); microcomputer…

Milia en plaque of the nose: report of a case and successful treatment with topical tretinoin.

PubMed

Nambudiri, Vinod E; Habib, Nancy; Arndt, Kenneth A; Kane, Kay S

2014-05-01

Milia are benign, superficial keratinaceous cysts that present as fine, small white papules. Milia en plaque is a rare, challenging-to-treat variant most often seen in the posterior auricular region. A total of 9 cases of milia en plaque have been reported in the pediatric literature to date. We report a case of milia en plaque of the nose in a 7-year-old boy, a novel site of involvement in the pediatric population, and successful treatment with the use of topical tretinoin. Topical retinoids offer an effective treatment option for the management of milia en plaque in the pediatric population. Copyright © 2014 by the American Academy of Pediatrics.

Inter-Korean military confidence building after 2003.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tae-woo, Kim; Littlefield, Adriane C.; Vannoni, Michael Geoffrey

2003-08-01

Tensions on the Korean Peninsula remain high despite a long-term strategy by South Korea to increase inter-Korean exchanges in economics, culture, sports, and other topics. This is because the process of reconciliation has rarely extended to military and security topics and those initiatives that were negotiated have been ineffective. Bilateral interactions must include actions to reduce threats and improve confidence associated with conventional military forces (land, sea, and air) as well as nuclear, chemical, and biological activities that are applicable to developing and producing weapons of mass destruction (WMD). The purpose of this project is to develop concepts for inter-Koreanmore » confidence building measures (CBMs) for military and WMD topics that South Korea could propose to the North when conditions are right. This report describes the historical and policy context for developing security-related CBMs and presents an array of bilateral options for conventional military and WMD topics within a consistent framework. The conceptual CBMs address two scenarios: (1) improved relations where construction of a peace regime becomes a full agenda item in inter-Korean dialogue, and (2) continued tense inter-Korean relations. Some measures could be proposed in the short term under current conditions, others might be implemented in a series of steps, while some require a higher level of cooperation than currently exists. To support decision making by political leaders, this research focuses on strategies and policy options and does not include technical details.« less

Guideline for the diagnosis and treatment of scabies in Japan (third edition): Executive Committee of Guideline for the Diagnosis and Treatment of Scabies.

PubMed

2017-09-01

In the current work, we present our new guideline for the diagnosis and treatment of scabies which we, the Executive Committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 led to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. In this guideline, we introduce criteria for a proper diagnosis of scabies, treatment algorithm for common and crusted (hyperkeratotic) scabies, and prevention. The major change from our second edition is the treatment algorithm. As phenothrin is now available, the first-line therapy for common scabies is either topical phenothrin lotion or oral ivermectin. The second-line option for topical treatment is sulfur-containing ointments, crotamiton cream or benzyl benzoate lotion. γ-Benzene hexachloride ointment is no longer provided for clinical use. In an immunosuppressed patient, the treatment option is still the same, but with close follow up. If the symptoms persist, diagnosis and treatment must be reassessed. For hyperkeratotic scabies and nail scabies, removal of thick crust, cutting of nails and occlusive dressing are additionally required. The safety and effectiveness of combined treatment with topical and oral medications are not yet confirmed. Further assessment is needed. In addition to appropriate treatment, it is essential to educate patients and health-care workers and to conduct epidemiological studies to prevent further spread of the disease through effectively utilizing available resources including manpower, finance, logistics and time. © 2017 Japanese Dermatological Association.

Star Formation in Galaxies

NASA Technical Reports Server (NTRS)

1987-01-01

Topics addressed include: star formation; galactic infrared emission; molecular clouds; OB star luminosity; dust grains; IRAS observations; galactic disks; stellar formation in Magellanic clouds; irregular galaxies; spiral galaxies; starbursts; morphology of galactic centers; and far-infrared observations.

Entrepreneurship as a Career Choice.

ERIC Educational Resources Information Center

Ashmore, M. Catherine; And Others

This curriculum guide is designed to provide some basic materials to assist in developing an introductory approach to entrepreneurship as a career option. Chapter 1 presents an overview of entrepreneurship education and possible teaching strategies, including a topical outline, resource suggestions, detailed descriptions of available curriculum…

Information Technology for Economic and Social Benefit--Options for Bangladesh.

ERIC Educational Resources Information Center

Bhuiyan, Farhad Ali

2002-01-01

Considers how information technology (IT) can help socioeconomic growth of developing countries based on experiences in Bangladesh. Topics include Bangladesh's development plans; future economic growth trends triggered by IT; emerging technologies; intellectual and societal development; industrial revolutions; telematics; regional and world…

Alternate-Fuel Vehicles and Their Application in Schools.

ERIC Educational Resources Information Center

Taggart, Chip

1991-01-01

Alternative fuels are becoming increasingly attractive from environmental, energy independence, and economic perspectives. Addresses the following topics: (1) federal and state legislation; (2) alternative fuels and their attributes; (3) practical experience with alternative-fuel vehicles in pupil transportation; and (4) options for school…

Aerospace engineering educational program

NASA Technical Reports Server (NTRS)

Craft, William; Klett, David; Lai, Steven

1992-01-01

The principle goal of the educational component of NASA CORE is the creation of aerospace engineering options in the mechanical engineering program at both the undergraduate and graduate levels. To accomplish this goal, a concerted effort during the past year has resulted in detailed plans for the initiation of aerospace options in both the BSME and MSME programs in the fall of 1993. All proposed new courses and the BSME aerospace option curriculum must undergo a lengthy approval process involving two cirriculum oversight committees (School of Engineering and University level) and three levels of general faculty approval. Assuming approval is obtained from all levels, the options will officially take effect in Fall '93. In anticipation of this, certain courses in the proposed curriculum are being offered during the current academic year under special topics headings so that current junior level students may graduate in May '94 under the BSME aerospace option. The proposed undergraduate aerospace option curriculum (along with the regular mechanical engineering curriculum for reference) is attached at the end of this report, and course outlines for the new courses are included in the appendix.

MedlinePlus Connect: Frequently Asked Questions (FAQs)

MedlinePlus

... topic data in XML format. Using the Web service, software developers can build applications that utilize MedlinePlus health topic information. The service accepts keyword searches as requests and returns relevant ...

Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations.

PubMed

Rudmik, Luke; Hoy, Monica; Schlosser, Rodney J; Harvey, Richard J; Welch, Kevin C; Lund, Valerie; Smith, Timothy L

2013-04-01

Topical therapies have become an integral component in the management plan for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based approach for the utilization of topical therapies in the management of CRS. A systematic review of the literature was performed and the guidelines for development of an evidence-based review with recommendations were followed. Study inclusion criteria were: adult population >18 years old; chronic rhinosinusitis (CRS) based on published diagnostic criteria; and clearly defined primary clinical end-point. We focused on reporting higher-quality studies (level 2b or higher), but reported on lower-level studies if the topic contained insufficient evidence. We excluded drug-eluting spacer and stent therapy from this review. This review identified and evaluated the literature on 5 topical therapy strategies for CRS: saline irrigation, topical steroid, topical antibiotic, topical antifungal, and topical alternatives (surfactant, manuka honey, and xylitol irrigations). Based on the available evidence, sinonasal saline irrigation and standard topical nasal steroid therapy are recommended in the topical treatment of CRS. Nonstandard (off-label) topical sinonasal steroid therapies can be an option for managing CRS. The evidence recommends against the use of topical antifungal therapy and topical antibiotic therapy delivered using nebulized and spray techniques in routine cases of CRS. There is insufficient clinical research to provide recommendations for alternative therapies or topical antibiotic therapy delivered using other delivery methods (eg, irrigations). © 2013 ARS-AAOA, LLC.

Norwegian crusted scabies: an unusual case presentation.

PubMed

Maghrabi, Michael M; Lum, Shireen; Joba, Ameha T; Meier, Molly J; Holmbeck, Ryan J; Kennedy, Kate

2014-01-01

Scabies is a contagious condition that is transmitted through direct contact with an infected person and has been frequently associated with institutional and healthcare-facility outbreaks. The subtype Norwegian crusted scabies can masquerade as other dermatologic diseases owing to the heavy plaque formation. Successful treatment has been documented in published reports, including oral ivermectin and topical permethrin. Few case studies documenting the treatment of Norwegian crusted scabies have reported the use of surgical debridement as an aid to topical and/or oral treatment when severe plaque formation has been noted. A nursing home patient was admitted to the hospital for severe plaque formation of both feet. A superficial biopsy was negative for both fungus and scabies because of the severity of the plaque formation on both feet. The patient underwent a surgical, diagnostic biopsy of both feet, leading to the diagnosis of Norwegian crusted scabies. A second surgical debridement was then performed to remove the extensive plaque formation and aid the oral ivermectin and topical permethrin treatment. The patient subsequently made a full recovery and was discharged back to the nursing home. At 2 and 6 months after treatment, the patient remained free of scabies infestation, and the surgical wound had healed uneventfully. The present case presentation has demonstrated that surgical debridement can be complementary to the standard topical and oral medications in the treatment of those with Norwegian crusted scabies infestation. Copyright © 2014 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

3-D Imagery Cockpit Display Development

DTIC Science & Technology

1990-08-01

and ownship appeared in the lower right corner of the CLF, in the form XXX NM. The third data line showed individual aircraft altitude in the form XX K...data line showed aircraft heading in the form XXX ° . 4.2.5.3 Close-Look Format Options The Close-Look Format option switches are shown in Figure 4.2...vector, it is Need for declutter levels, redundant. Need range readout. Needs basic altitude reference. Low altitude warning system with sexy female

Onychomycosis Diagnosis and Management: Perspectives from a Joint Dermatology-Podiatry Roundtable.

PubMed

Scher, Richard K; Tosti, Antonella; Joseph, Warren S; Vlahovic, Tracey C; Plasencia, Jesse; Markinson, Bryan C; Pariser, David M

2015-09-01

Onychomycosis prevalence is expected to rise as the population ages and the prevalence of diabetes, peripheral vascular disease, and other significant risk factors rise. Until recently, treatment options were limited due to safety concerns with oral antifungals and low efficacy with available topical agents. Efinaconzole and tavaborole were approved by the FDA in 2014 for onychomycosis treatment and provide additional effective topical treatment options for patients with mild-to-moderate disease. Dermatologists and podiatrists both regularly treat onychomycosis, yet there are striking differences between specialties in approach to diagnosis and treatment. In order to explore these differences a joint dermatology-podiatry roundtable of onychomycosis experts was convened. Although it has little effect on mycologic cure, debridement may be a valuable adjunct to oral or topical antifungal therapy, especially in patients with greater symptom burden. However, few dermatologists incorporate debridement into their treatment plans and referral to podiatry may be appropriate for some of these patients. Furthermore, podiatrists may be better equipped to manage patients with concurrent diabetes or peripheral vascular disease and elderly patients who are unable to maintain proper foot hygiene. Once cure is achieved, lifestyle and hygiene practices, maintenance/prophylactic onychomycosis treatment, and proactive tinea pedis treatment in patients and family members may help to maintain patients' cured status.

Verbal Final Exam in Introductory Biology Yields Gains in Student Content Knowledge and Longitudinal Performance

PubMed Central

Luckie, Douglas B.; Rivkin, Aaron M.; Aubry, Jacob R.; Marengo, Benjamin J.; Creech, Leah R.; Sweeder, Ryan D.

2013-01-01

We studied gains in student learning over eight semesters in which an introductory biology course curriculum was changed to include optional verbal final exams (VFs). Students could opt to demonstrate their mastery of course material via structured oral exams with the professor. In a quantitative assessment of cell biology content knowledge, students who passed the VF outscored their peers on the medical assessment test (MAT), an exam built with 40 Medical College Admissions Test (MCAT) questions (66.4% [n = 160] and 62% [n = 285], respectively; p < 0.001);. The higher-achieving students performed better on MCAT questions in all topic categories tested; the greatest gain occurred on the topic of cellular respiration. Because the VF focused on a conceptually parallel topic, photosynthesis, there may have been authentic knowledge transfer. In longitudinal tracking studies, passing the VF also correlated with higher performance in a range of upper-level science courses, with greatest significance in physiology, biochemistry, and organic chemistry. Participation had a wide range but not equal representation in academic standing, gender, and ethnicity. Yet students nearly unanimously (92%) valued the option. Our findings suggest oral exams at the introductory level may allow instructors to assess and aid students striving to achieve higher-level learning. PMID:24006399

Verbal final exam in introductory biology yields gains in student content knowledge and longitudinal performance.

PubMed

Luckie, Douglas B; Rivkin, Aaron M; Aubry, Jacob R; Marengo, Benjamin J; Creech, Leah R; Sweeder, Ryan D

2013-01-01

We studied gains in student learning over eight semesters in which an introductory biology course curriculum was changed to include optional verbal final exams (VFs). Students could opt to demonstrate their mastery of course material via structured oral exams with the professor. In a quantitative assessment of cell biology content knowledge, students who passed the VF outscored their peers on the medical assessment test (MAT), an exam built with 40 Medical College Admissions Test (MCAT) questions (66.4% [n = 160] and 62% [n = 285], respectively; p < 0.001);. The higher-achieving students performed better on MCAT questions in all topic categories tested; the greatest gain occurred on the topic of cellular respiration. Because the VF focused on a conceptually parallel topic, photosynthesis, there may have been authentic knowledge transfer. In longitudinal tracking studies, passing the VF also correlated with higher performance in a range of upper-level science courses, with greatest significance in physiology, biochemistry, and organic chemistry. Participation had a wide range but not equal representation in academic standing, gender, and ethnicity. Yet students nearly unanimously (92%) valued the option. Our findings suggest oral exams at the introductory level may allow instructors to assess and aid students striving to achieve higher-level learning.

Space station systems analysis study. Part 2, volume 3: Appendixes, Book 2: Supporting data (7 through 18)

NASA Technical Reports Server (NTRS)

1977-01-01

Topics discussed include: (1) design considerations for a MARS sample return laboratory module for space station investigations; (2) crew productivity as a function of work shift arrangement; (3) preliminary analysis of the local logistics problem on the space construction base; (4) mission hardware construction operational flows and timelines; (5) orbit transfer vehicle concept definition; (6) summary of results and findings of space processing working review; (7) crew and habitability subsystem (option L); (8) habitability subsystem considerations for shuttle tended option L; (9) orbiter utilization in manned sortie missions; (10) considerations in definition of space construction base standard module configuration (option L); (11) guidance, control, and navigation subsystems; and (12) system and design tradeoffs.

Topical Treatments for Localized Neuropathic Pain.

PubMed

Casale, Roberto; Symeonidou, Z; Bartolo, M

2017-03-01

Topical therapeutic approaches in localized neuropathic pain (LNP) syndromes are increasingly used by both specialists and general practitioners, with a potentially promising effect on pain reduction. In this narrative review, we describe the available compounds for topical use in LNP syndromes and address their potential efficacy according to the literature. Local anaesthetics (e.g., lidocaine, bupivacaine and mepivacaine), as well as general anaesthetic agents (e.g., ketamine), muscle relaxants (e.g., baclofen), capsaicin, anti-inflammatory drugs (e.g., diclofenac), salicylates, antidepressants (e.g., amitriptyline and doxepin), α2 adrenergic agents (e.g., clonidine), or even a combination of them have been tested in various applications for the treatment of LNP. Few of them have reached a sufficient level of evidence to support systematic use as treatment options. Relatively few systemic side effects or drug-drug interactions and satisfactory efficacy seem to be the benefits of topical treatments. More well-organized and tailored studies are necessary for the further conceptualization of topical treatments for LNP.

Topical amitriptyline and ketamine for the treatment of neuropathic pain.

PubMed

Mercadante, Sebastiano

2015-01-01

A neuropathy is a disturbance of function or pathological change in nerves. In some cases, peripheral neuropathic pain may occur due to a lesion or disease of the peripheral somatosensory nervous system. Efficacy of different agents for peripheral neuropathic pain conditions is less than optimal. The administration of topical analgesics might be an option, due to the potential of reduced adverse effects and increased patient compliance. There is major interest in compounding topical analgesics for peripheral neuropathic pain, but several challenges remain for this approach. Topical analgesics have the potential to be a valuable additional approach for the management of peripheral neuropathic pain. Topical amitriptyline-ketamine combination (AK) is a promising agent for peripheral neuropathic pain conditions. Some studies have shown its efficacy in neuropathic pain conditions. However, this data was not uniformely obtained and its role remains still controversial. Efficacy may depend on many factors, including the choice of the vehicle, the concentration, the pain site, and specific diseases. More studies are necessary to support the use of AK in clinical practice.

Some unconventional approaches to the exploration of Mars

NASA Astrophysics Data System (ADS)

French, J. R.

1991-02-01

The topics of space transport to Mars, and surface transport and surface operations on Mars are discussed in detail and new options for accomplishing these activities are presented. The question of maximizing the return on the investment in a Mars mission is addressed. One way to accomplish this is through reduction of propellant requirements by increasing the performance of the rocket engine, while another option is to make use of nuclear fuel. A technique discussed in detail would provide a means to manufacture fuel from Martian resources for both the return trip and for Mars surface exploration. Options for Mars surface transport include battery and nuclear powered rovers, solar powered automobiles, and either battery, nuclear or Mars-generated-propellant-powered aircraft specially designed to explore the Martian surface. The advantages and disadvantages of each of these options are considered, and the usefulness of a manned aircraft for both exploration and surface operational functions is discussed.

The Tricky Tear Trough

PubMed Central

Belden, Sarah; Miller, Richard A.

2015-01-01

There is a growing demand for noninvasive anti-aging products for which the periorbital region serves as a critical aspect of facial rejuvenation. This article reviews a multitude of cosmeceutical ingredients that have good scientific data, specifically for the periorbital region. Topical treatment options have exponentially grown from extensively studied retinoids, to recently developed technology, such as growth factors and peptides. With a focus on the periorbital anatomy, the authors review the mechanisms of action of topical cosmeceutical ingredients, effectiveness of ingredient penetration through the stratum corneum, and validity of clinical trials. PMID:26430490

Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Moderate-to-Severe Plaque Psoriasis: Results of two Phase 3 randomized controlled trials.

PubMed

Gold, Linda Stein; Lebwohl, Mark G; Sugarman, Jeffrey L; Pariser, David M; Lin, Tina; Martin, Gina; Pillai, Radhakrishnan; Israel, Robert; Ramakrishna, Tage

2018-03-31

Topical corticosteroids are the mainstay of psoriasis treatment; long-term safety concerns limit use. Combination with tazarotene may optimize efficacy, minimizing safety/tolerability concerns, In patients with moderate-to-severe plaque psoriasis treated with HP/TAZ lotion, improvement is noted within 2 weeks with few adverse effects observed after 8 weeks., HP/TAZ lotion may provide a realistic topical option for psoriasis management. Copyright © 2018. Published by Elsevier Inc.

The therapeutic effects of a topical tretinoin and corticosteroid combination for vitiligo: a placebo-controlled, paired-comparison, left-right study.

PubMed

Kwon, Hyok Bu; Choi, Yunseok; Kim, Hwa Jung; Lee, Ai-Young

2013-04-01

Topical all-trans-retinoic acid (tretinoin) prevents skin atrophy induced by long-term use of topical corticosteroids, without abrogating their anti-inflammatory effects. The goal of this study was to determine the efficacy of tretinoin plus topical corticosteroids (tretinoin plus) for repigmentation in patients with vitiligo. A placebo-controlled, paired-comparison, left-right study was conducted for a period of 6 months on tretinoin plus and the vehicle plus the same topical corticosteroid (vehicle plus) treatment in 50 patients diagnosed with generalized vitiligo. Clinical responses were assessed using the computerized analysis, and the results were compared with the visual analysis. The percentage agreement between the 2 analyses was 91.8%. Among 49 participants who successfully completed this study, 27 (55%) showed a better response to tretinoin plus than to vehicle plus. The improved response was noted at an early stage of treatment, during the first 3 months in 60% of patients. Combined therapy with tretinoin plus topical corticosteroids is safe and effective and provides another option for treatment of patients with vitiligo.

Emerging topical onychomycosis therapies - quo vadis?

PubMed

Elkeeb, Rania; Hui, Xiaoying; Murthy, Narasimha; Maibach, Howard I

2014-12-01

Onychomycosis, a common chronic fungal infection affecting fingernails and toenails, globally may affect 10 - 30% of the population. This chronic disease is difficult to eradicate. The goal of developing a highly effective and safe topical treatment has not yet been reached as it depends on the type of onychomycosis and the variety of invaders. Topical drug delivery to the nail is highly desirable in treating nail disorders. However, efficacy of topical therapies is low due to their limited permeability across the nail plate. Advances have especially been made by the development of new therapeutic options including new drug entities, new formulations and reformulations. This overview updates emerging topical treatments for onychomycosis, research progress and future perspectives. Development of novel effective noninvasive topical therapy for treating onychomycosis and other nail diseases such as psoriasis is long overdue. Previously there was a lack of basic knowledge about nail and its barrier properties, but with the recent increased interest in this field both from industry and academia, we hope extensive research will continue in this field to bring about successful and safe treatments for such chronic diseases.

Options and limitations for bromate control during ozonation of wastewater.

PubMed

Soltermann, Fabian; Abegglen, Christian; Tschui, Manfred; Stahel, Sandro; von Gunten, Urs

2017-06-01

Wastewater treatment plants (WWTPs) are important point sources for micropollutants, which are harmful to freshwater organisms. Ozonation of wastewater is a powerful option to abate micropollutants, but may result in the formation of the potentially toxic oxidation by-product bromate in bromide-containing wastewaters. This study investigates options to reduce bromate formation during wastewater ozonation by (i) reducing the bromide concentration of the wastewater, (ii) lowering the ozone dose during wastewater treatment and (iii) adding hydrogen peroxide to limit the lifetime of ozone and quench the intermediates of the bromate formation pathway. Two examples demonstrate that a high share of bromide in wastewater can originate from single point sources (e.g., municipal waste incinerators or landfills). The identification of major point sources requires laborious sampling campaigns, but may facilitate the reduction of the bromide load significantly. To reduce the bromate formation by lowering the ozone dose interferes with the aim to abate micropollutants. Therefore, an additional treatment is necessary to ensure the elimination of micropollutants. Experiments at a pilot-plant illustrate that a combined treatment (ozone/powdered activated carbon) allows to eliminate micropollutants with low bromate yields. Furthermore, the addition of hydrogen peroxide was investigated at bench-scale. The bromate yields could be reduced by ∼50% and 65% for a hydrogen peroxide dose of 5 and 10 mg L -1 , respectively. In conclusion, there are options to reduce the bromate formation during wastewater ozonation, however, they are not simple with sometimes limited efficiency. Copyright © 2017 Elsevier Ltd. All rights reserved.

Copyright Management for Scholarship

ERIC Educational Resources Information Center

Petersen, Rodney J.

2004-01-01

This article describes the author's experience working with copyright and teachers' level of awareness or unawareness of the basics about copyright. The article is divided into sections on the following topics: Rewards for Authors; Hypothetical Scenarios; Options for Managing Authors' Rights; and Emerging Principles for Scholarly Communications.…

The GUI OPAC: Approach with Caution.

ERIC Educational Resources Information Center

Hildreth, Charles R.

1995-01-01

Discusses the graphical user interface (GUI) online public access catalog (OPAC), a user interface that uses images to represent options. Topics include user interface design for information retrieval; designing effective bibliographic displays, including subject headings; two design principles; and what GUIs can bring to OPACs. (LRW)

Evaluation of School Library Media Centers: Demonstrating Quality.

ERIC Educational Resources Information Center

Everhart, Nancy

2003-01-01

Discusses ways to evaluate school library media programs and how to demonstrate quality. Topics include how principals evaluate programs; sources of evaluative data; national, state, and local instruments; surveys and interviews; Colorado benchmarks; evaluating the use of electronic resources; and computer reporting options. (LRW)

Virtual Events: A Cyberspace Resource for Educators.

ERIC Educational Resources Information Center

McLellan, Hilary

1998-01-01

Discusses how virtual events can be used to enhance education. Topics include balancing virtual and real encounters; finding the best mix of communication options; and finding patterns of interaction that support reflective cognition, knowledge amplification, community-building, learning, and global understanding. GLOBENET 1997, an international…

School Energy Costs: A Matter of Leadership.

ERIC Educational Resources Information Center

Newton, Larry; Woodbury, Darwin; Glenn, Michael L.

This booklet offers energy savings concepts for Utah's public school districts. Topics cover energy efficient design for new buildings and additions, cost-effective energy upgrades during retrofits, maintenance and operating procedures for increasing energy efficiency, and funding options for school districts making energy upgrades. Appendices…

Pricing Models and Payment Schemes for Library Collections.

ERIC Educational Resources Information Center

Stern, David

2002-01-01

Discusses new pricing and payment options for libraries in light of online products. Topics include alternative cost models rather than traditional subscriptions; use-based pricing; changes in scholarly communication due to information technology; methods to determine appropriate charges for different organizations; consortial plans; funding; and…

Kodak Optical Disk and Microfilm Technologies Carve Niches in Specific Applications.

ERIC Educational Resources Information Center

Gallenberger, John; Batterton, John

1989-01-01

Describes the Eastman Kodak Company's microfilm and optical disk technologies and their applications. Topics discussed include WORM technology; retrieval needs and cost effective archival storage needs; engineering applications; jukeboxes; optical storage options; systems for use with mainframes and microcomputers; and possible future…

Science for Society. A Bibliography.

ERIC Educational Resources Information Center

Moore, John A.

This bibliography, intended primarily for secondary school teachers and students, has been published "to help many become better educated and wiser in respect to the present predicaments and present options facing mankind." It contains 1,500 citations subsumed under the following topics: general references; population problems, agriculture, food…

Chemical pharmacotherapy options for managing adult acne.

PubMed

Vera, Nora; Patel, Nupur; Cardwell, Leah A; Saleem, Mohammed; Feldman, Steven R

2017-02-01

The incidence of adult acne is increasing worldwide. Despite clinical overlap with conventional acne, it has distinct features. Areas covered: A literature search of English-language review articles, randomized control studies and retrospective studies conducted over the past 30 years was performed using PubMed and Google Scholar. Search terms included acne, adult, topical medication, oral medication and skin of color. We highlight important clinical features and treatment modalities pertinent to the evaluation and management of adult acne. Given the relative dearth of literature detailing treatment options specific to adult acne, we offer expert opinion regarding management of the condition especially in special populations such as skin of color and pregnancy. Expert Opinion: It is unclear whether adult acne represents a distinct entity or a continuum of adolescent disease. Providers may opt to use topical medication as first-line, but should have a low threshold for switching to systemic therapy given the magnitude of psychosocial and emotional burden associated with the condition.

Using Facebook as an informal learning environment.

PubMed

Cain, Jeff; Policastri, Anne

2011-12-15

To create, implement, and assess the effectiveness of an optional Facebook activity intended to expose students to contemporary business issues not covered in the core content of a pharmacy management and leadership course and to perspectives of experts and thought leaders external to their university. An informal learning strategy was used to create a Facebook group page and guest experts were identified and invited to submit posts pertaining to business-related topics. Students were given instructions for joining the Facebook group but informed that participation was optional. A mixed-methods approach using a student questionnaire, results on examination questions, and a student focus group was used to assess this activity. The informal design with no posting guidelines and no participation requirement was well received by students, who appreciated the unique learning environment and exposure to external experts. Facebook provides an informal learning environment for presenting contemporary topics and the thoughts of guest experts not affiliated with a college or school, thereby exposing students to relevant "real world" issues.

Using Facebook as an Informal Learning Environment

PubMed Central

Policastri, Anne

2011-01-01

Objective. To create, implement, and assess the effectiveness of an optional Facebook activity intended to expose students to contemporary business issues not covered in the core content of a pharmacy management and leadership course and to perspectives of experts and thought leaders external to their university. Design. An informal learning strategy was used to create a Facebook group page and guest experts were identified and invited to submit posts pertaining to business-related topics. Students were given instructions for joining the Facebook group but informed that participation was optional. Assessment. A mixed-methods approach using a student questionnaire, results on examination questions, and a student focus group was used to assess this activity. The informal design with no posting guidelines and no participation requirement was well received by students, who appreciated the unique learning environment and exposure to external experts. Conclusions. Facebook provides an informal learning environment for presenting contemporary topics and the thoughts of guest experts not affiliated with a college or school, thereby exposing students to relevant “real world” issues. PMID:22345726

Topical retinoids in acne vulgaris: update on efficacy and safety.

PubMed

Thielitz, Anja; Gollnick, Harald

2008-01-01

Topical retinoids represent a mainstay of acne treatment because they expel mature comedones, reduce microcomedone formation, and exert anti-inflammatory effects. The first-generation retinoid tretinoin (all-trans retinoic acid) and the synthetic third-generation polyaromatics adapalene and tazarotene are approved for acne treatment by the US FDA, whereas topical tretinoin, isotretinoin (13-cis retinoic acid), and adapalene are accredited in Canada and Europe. Topical retinoids have a favorable safety profile distinct from the toxicity of their systemic counterparts. Local adverse effects, including erythema, dryness, itching, and stinging, occur frequently during the early treatment phase. Their impact varies with the vehicle formation, skin type, frequency and mode of application, use of moisturizers, and environmental factors such as sun exposure or temperature. The broad anti-acne activity and safety profile of topical retinoids justifies their use as first-line treatment in most types of non-inflammatory and inflammatory acne. They are also suitable as long-term medications, with no risk of inducing bacterial resistance, for maintenance of remission after cessation of initial combination therapy.

Do Sequentially-Presented Answer Options Prevent the Use of Testwiseness Cues on Continuing Medical Education Tests?

ERIC Educational Resources Information Center

Willing, Sonja; Ostapczuk, Martin; Musch, Jochen

2015-01-01

Testwiseness--that is, the ability to find subtle cues towards the solution by the simultaneous comparison of the available answer options--threatens the validity of multiple-choice (MC) tests. Discrete-option multiple-choice (DOMC) has recently been proposed as a computerized alternative testing format for MC tests, and presumably allows for a…

Space station data system analysis/architecture study. Task 3: Trade studies, DR-5, volume 1

NASA Technical Reports Server (NTRS)

1985-01-01

The primary objective of Task 3 is to provide additional analysis and insight necessary to support key design/programmatic decision for options quantification and selection for system definition. This includes: (1) the identification of key trade study topics; (2) the definition of a trade study procedure for each topic (issues to be resolved, key inputs, criteria/weighting, methodology); (3) conduct tradeoff and sensitivity analysis; and (4) the review/verification of results within the context of evolving system design and definition. The trade study topics addressed in this volume include space autonomy and function automation, software transportability, system network topology, communications standardization, onboard local area networking, distributed operating system, software configuration management, and the software development environment facility.

TOPICAL TREATMENT OF MELASMA

PubMed Central

Bandyopadhyay, Debabrata

2009-01-01

Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma. PMID:20101327

Topical Prophylaxis for HIV Prevention in Women: Becoming a Reality

PubMed Central

Verma, Natasha A.; Lee, Anna C.; Herold, Betsy C.

2011-01-01

Strategies to protect against sexual transmission of HIV include the development of products formulated for topical application, which limit the toxicities associated with systemic oral pre-exposure prophylaxis. Following several clinical trial failures, attention is now focused on antiretroviral (ARV) agents. Highly potent ARV topical formulations provide a female-controlled, targeted, and feasible option for HIV prevention. A recently completed tenofovir gel trial was the first to demonstrate significant protection against HIV acquisition. Topical ARVs have the advantage of delivering high concentration of drug at the site of transmission of HIV, with low systemic absorption. Sustained-release formulations, such as intravaginal rings, will likely improve adherence and can be designed to provide controlled and continuous delivery of ARV combinations. Further studies to test alternative dosing strategies and pharmacokinetic/pharmacodynamic relationships in the genital tract will provide valuable information as the field strives to improve upon the promising tenofovir gel trial results. PMID:21424725

Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts.

PubMed

Khattar, Joe A; Musharrafieh, Umayya M; Tamim, Hala; Hamadeh, Ghassan N

2007-04-01

Warts are a common dermatologic problem. Treatment is painful, prolonged, and can cause scarring. To evaluate topical zinc oxide for the treatment of warts. This was a randomized, double-blind controlled trial of 44 patients. Twenty-two patients were given topical zinc oxide 20% ointment, and the other 22 received salicylic acid 15% + lactic acid 15% ointment twice daily. All patients were followed up for 3 months or until cure, whichever occurred first. All patients were observed for side-effects. Sixteen patients in the zinc group and 19 in the salicylic acid-lactic acid group completed the study. In the zinc oxide-treated group, 50% of the patients showed complete cure and 18.7% failed to respond, compared with 42% and 26%, respectively, in the salicylic acid-lactic acid-treated group. No patients developed serious side-effects. Topical zinc oxide is an efficacious, painless, and safe therapeutic option for wart treatment.

Multiple superficial basal cell carcinomata--topical imiquimod versus curette and cryotherapy.

PubMed

Dixon, Anthony J

2005-01-01

Superficial basal cell carcinoma can be successfully managed by means other than surgical excision. Nonexcisional approaches include topical imiquimod, and curette and cryotherapy (C&C). This article discusses the management of an insulin dependent diabetic man aged 52 years presenting with 17 torso basal cell carcinomas (BCCs); mostly superficial BCCs (SBCCs). Half were treated with topical imiquimod. The remaining lesions were treated with curette and cryotherapy. All lesions resolved with proven histologic clearance. The patient considered C&C caused him less discomfort and disruption. He developed a late secondary infection in some sites treated with imiquimod. At 12 months there was no evidence of recurrence though new nodular BCCs and SBCCs had developed elsewhere on his upper torso. He has elected to have future SBCCs managed with C&C. While excisional surgery remains the benchmark management for nonmelanoma skin cancer, topical imiquimod and C&C are important options for treating SBCCs.

Strategies of persuasion in offers to participate in cancer clinical trials I: Topic placement and topic framing.

PubMed

Barton, Ellen; Eggly, Susan; Winckles, Andrew; Albrecht, Terrance L

2014-01-01

Clinical trials are the gold standard in medical research evaluating new treatments in cancer care; however, in the United States, too few patients enroll in trials, especially patients from minority groups. Offering patients the option of a clinical trial is an ethically-charged communicative event for oncologists. One particularly vexed ethical issue is the use of persuasion in trial offers. Based on a corpus of 22 oncology encounters with Caucasian-American (n = 11) and African-American (n = 11) patients, this discourse analysis describes oncologists' use of two persuasive strategies related to the linguistic structure of trial offers: topic placement and topic framing. Findings are presented in total and by patient race, and discussed in terms of whether these strategies may constitute ethical or unethical persuasion, particularly with respect to the ethical issue of undue influence and the social issue of underrepresentation of minorities in cancer clinical trials.

Numerical simulation of a rare winter hailstorm event over Delhi, India on 17 January 2013

NASA Astrophysics Data System (ADS)

Chevuturi, A.; Dimri, A. P.; Gunturu, U. B.

2014-12-01

This study analyzes the cause of the rare occurrence of a winter hailstorm over New Delhi/NCR (National Capital Region), India. The absence of increased surface temperature or low level of moisture incursion during winter cannot generate the deep convection required for sustaining a hailstorm. Consequently, NCR shows very few cases of hailstorms in the months of December-January-February, making the winter hail formation a question of interest. For this study, a recent winter hailstorm event on 17 January 2013 (16:00-18:00 UTC) occurring over NCR is investigated. The storm is simulated using the Weather Research and Forecasting (WRF) model with the Goddard Cumulus Ensemble (GCE) microphysics scheme with two different options: hail and graupel. The aim of the study is to understand and describe the cause of hailstorm event during over NCR with a comparative analysis of the two options of GCE microphysics. Upon evaluating the model simulations, it is observed that the hail option shows a more similar precipitation intensity with the Tropical Rainfall Measuring Mission (TRMM) observation than the graupel option does, and it is able to simulate hail precipitation. Using the model-simulated output with the hail option; detailed investigation on understanding the dynamics of hailstorm is performed. The analysis based on a numerical simulation suggests that the deep instability in the atmospheric column led to the formation of hailstones as the cloud formation reached up to the glaciated zone promoting ice nucleation. In winters, such instability conditions rarely form due to low level available potential energy and moisture incursion along with upper level baroclinic instability due to the presence of a western disturbance (WD). Such rare positioning is found to be lowering the tropopause with increased temperature gradient, leading to winter hailstorm formation.

Numerical simulation of a winter hailstorm event over Delhi, India on 17 January 2013

NASA Astrophysics Data System (ADS)

Chevuturi, A.; Dimri, A. P.; Gunturu, U. B.

2014-09-01

This study analyzes the cause of rare occurrence of winter hailstorm over New Delhi/NCR (National Capital Region), India. The absence of increased surface temperature or low level of moisture incursion during winter cannot generate the deep convection required for sustaining a hailstorm. Consequently, NCR shows very few cases of hailstorms in the months of December-January-February, making the winter hail formation a question of interest. For this study, recent winter hailstorm event on 17 January 2013 (16:00-18:00 UTC) occurring over NCR is investigated. The storm is simulated using Weather Research and Forecasting (WRF) model with Goddard Cumulus Ensemble (GCE) microphysics scheme with two different options, hail or graupel. The aim of the study is to understand and describe the cause of hailstorm event during over NCR with comparative analysis of the two options of GCE microphysics. On evaluating the model simulations, it is observed that hail option shows similar precipitation intensity with TRMM observation than the graupel option and is able to simulate hail precipitation. Using the model simulated output with hail option; detailed investigation on understanding the dynamics of hailstorm is performed. The analysis based on numerical simulation suggests that the deep instability in the atmospheric column led to the formation of hailstones as the cloud formation reached upto the glaciated zone promoting ice nucleation. In winters, such instability conditions rarely form due to low level available potential energy and moisture incursion along with upper level baroclinic instability due to the presence of WD. Such rare positioning is found to be lowering the tropopause with increased temperature gradient, leading to winter hailstorm formation.

Seeing is believing: the direct and contingent influence of pictures in health promotion advertising.

PubMed

Chang, Chingching

2013-01-01

Because pictures, compared with words, are more effective in triggering vivid imagery, their effects should increase in situations in which they play a crucial role in facilitating imagery. This study accordingly explored the relative effects of information presented in pictorial formats and verbal formats in health promotion advertising. Symptoms presented in pictorial formats increased perceptions of the severity of a disease, whereas prevention options presented in pictorial formats enhanced efficacy in preventing the disease. This study also examined two contingent situations: when people were oriented toward visual processing, and when imagery could not be easily triggered without the help of pictures, such as when symptoms or prevention options were difficult or unpleasant to imagine. The findings of three studies supported the offered predictions.

Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

PubMed Central

Choe, Sung Jay; Lee, Solam; Choi, Jaewoong

2017-01-01

Background A variety of agents have been used to treat female pattern hair loss (FPHL), including topical minoxidil, topical 17α-estradiol, oral anti-androgen agents, and mineral supplements. Compared with these single agent regimens, combination therapies could be a better therapeutic option in expectation of superior treatment outcome. Objective This study was designed to determine the efficacy of a combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil in Korean patients with FPHL. Methods Therapeutic efficacy was evaluated in 34 women who applied topical 0.025% 17α-estradiol and 3% minoxidil once daily for more than 6 months. Phototrichogram analysis was performed before and after therapy. The efficacy was evaluated with respect to total hair count, hair caliber (as assessed by phototrichogram analysis), and photographic assessment. Results Total hair count and hair caliber both increased from baseline to 6 months in patients treated with the combination therapy of topical 0.025% 17α-estradiol and 3% minoxidil (p<0.001). Photographic assessment also revealed significant disease improvement, thus supporting the therapeutic efficacy. Conclusion A combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil can be tried as an effective treatment for FPHL. PMID:28566902

Intelligent topical sentiment analysis for the classification of e-learners and their topics of interest.

PubMed

Ravichandran, M; Kulanthaivel, G; Chellatamilan, T

2015-01-01

Every day, huge numbers of instant tweets (messages) are published on Twitter as it is one of the massive social media for e-learners interactions. The options regarding various interesting topics to be studied are discussed among the learners and teachers through the capture of ideal sources in Twitter. The common sentiment behavior towards these topics is received through the massive number of instant messages about them. In this paper, rather than using the opinion polarity of each message relevant to the topic, authors focus on sentence level opinion classification upon using the unsupervised algorithm named bigram item response theory (BIRT). It differs from the traditional classification and document level classification algorithm. The investigation illustrated in this paper is of threefold which are listed as follows: (1) lexicon based sentiment polarity of tweet messages; (2) the bigram cooccurrence relationship using naïve Bayesian; (3) the bigram item response theory (BIRT) on various topics. It has been proposed that a model using item response theory is constructed for topical classification inference. The performance has been improved remarkably using this bigram item response theory when compared with other supervised algorithms. The experiment has been conducted on a real life dataset containing different set of tweets and topics.

Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation.

PubMed

Choe, Sung Jay; Lee, Solam; Choi, Jaewoong; Lee, Won-Soo

2017-06-01

A variety of agents have been used to treat female pattern hair loss (FPHL), including topical minoxidil, topical 17α-estradiol, oral anti-androgen agents, and mineral supplements. Compared with these single agent regimens, combination therapies could be a better therapeutic option in expectation of superior treatment outcome. This study was designed to determine the efficacy of a combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil in Korean patients with FPHL. Therapeutic efficacy was evaluated in 34 women who applied topical 0.025% 17α-estradiol and 3% minoxidil once daily for more than 6 months. Phototrichogram analysis was performed before and after therapy. The efficacy was evaluated with respect to total hair count, hair caliber (as assessed by phototrichogram analysis), and photographic assessment. Total hair count and hair caliber both increased from baseline to 6 months in patients treated with the combination therapy of topical 0.025% 17α-estradiol and 3% minoxidil ( p <0.001). Photographic assessment also revealed significant disease improvement, thus supporting the therapeutic efficacy. A combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil can be tried as an effective treatment for FPHL.

Scaling up IT: Weighing the Options, Maintaining the Balance.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie

1999-01-01

Discusses the integration of information technology into an institution of higher education, based on experiences at the University of Tennessee at Knoxville and the University of Michigan. Topics include changes in user populations; leadership; infrastructure; teamwork; organizational priorities; attitudes and expectations; and the constancy of…

Distance Education. [SITE 2001 Section].

ERIC Educational Resources Information Center

Fuller, Frank, Ed.; McBride, Ron, Ed.

This document contains the papers on distance education from the SITE (Society for Information Technology & Teacher Education) 2001 conference. Topics covered include: the distance education degree program for the Master of Mathematics with a teaching option at Texas A&M University; the evolution of online learning; Internet-based distance…

Issues and Developments in English and Applied Linguistics (IDEAL), 1994.

ERIC Educational Resources Information Center

Dickerson, Wayne B., Ed.; Kachru, Yamuna, Ed.

1994-01-01

Seven papers on topics of English-as-a-Second-Language (ESL) instruction, language research, and applied linguistics are presented: "ESL Students and Common L2 Conversation-Making Expressions" (Eli Hinkel); "Thematic Options in Reporting Previous Research" (Sarah Thomas, Thomas Hawes); "Connected Speech Modifications in…

High School Environmental Science Course Guide.

ERIC Educational Resources Information Center

Donovan, Edward P.; Korman, Barbara

A course in environmental science was developed to increase course options for students of all abilities and interest levels. Major topic areas of the course include: introduction to ecological principles and ecosystems; extinction of species; human population dynamics; agricultural systems and pest control; air quality; water quality; solid…

Laptop Lessons: Exploring the Promise of One-to-One Computing.

ERIC Educational Resources Information Center

Carter, Kim

2001-01-01

Describes benefits of programs where schools provide laptop computers for each student. Topics include results of studies that show positive learning outcomes; funding options; implementation; protecting the equipment; resources for learning about laptop programs; staff training and support; and future possibilities, including the implications of…

The YouTube Makeup Class

NASA Astrophysics Data System (ADS)

Haase, David G.

2009-05-01

When a college instructor goes out of town and must miss a lecture, the standard options are to cancel the class meeting or to enlist a colleague to fill in. In the former case a teaching opportunity is lost; in the latter the substitute may not lead the class in the same way as the instructor. Some students routinely skip lectures by a guest instructor, in the belief that the material in the substitute lecture will not be covered on the exam. There are other makeup options such as a directed study assignment. For instance, a missed class is sometimes a good opportunity to require students to investigate web-based simulations such as Physlets® that illustrate the class topics. These are most effective if the students are given a clear structure and if there are questions that the students must answer from their investigations with the Physlets. But many students are more comfortable with the audio and visual communication that occurs in the classroom. Web 2.0 technology, e.g., YouTube (http://www.youtube.com), makes it convenient for faculty to upload videos of lectures and demonstrations that can be used for makeup classes. College students already use YouTube for entertainment, and the YouTube format is simple to view on any web-connected computer. Although some universities have highly developed media delivery systems, YouTube is extremely convenient and accessible by anyone. This paper discusses how a YouTube makeup class can be efficiently produced and structured to be an effective learning experience.

Current focus of stem cell application in retinal repair

PubMed Central

Alonso-Alonso, María L; Srivastava, Girish K

2015-01-01

The relevance of retinal diseases, both in society’s economy and in the quality of people’s life who suffer with them, has made stem cell therapy an interesting topic for research. Embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adipose derived mesenchymal stem cells (ADMSCs) are the focus in current endeavors as a source of different retinal cells, such as photoreceptors and retinal pigment epithelial cells. The aim is to apply them for cell replacement as an option for treating retinal diseases which so far are untreatable in their advanced stage. ESCs, despite the great potential for differentiation, have the dangerous risk of teratoma formation as well as ethical issues, which must be resolved before starting a clinical trial. iPSCs, like ESCs, are able to differentiate in to several types of retinal cells. However, the process to get them for personalized cell therapy has a high cost in terms of time and money. Researchers are working to resolve this since iPSCs seem to be a realistic option for treating retinal diseases. ADMSCs have the advantage that the procedures to obtain them are easier. Despite advancements in stem cell application, there are still several challenges that need to be overcome before transferring the research results to clinical application. This paper reviews recent research achievements of the applications of these three types of stem cells as well as clinical trials currently based on them. PMID:25914770

Efficacy of combination of glycolic acid peeling with topical regimen in treatment of melasma.

PubMed

Chaudhary, Savita; Dayal, Surabhi

2013-10-01

Various treatment modalities are available for management of melasma, ranging from topical and oral to chemical peeling, but none is promising alone. Very few studies are available regarding efficacy of combination of topical treatment with chemical peeling. Combination of chemical peeling and topical regimen can be a good treatment modality in the management of this recalcitrant disorder. To assess the efficacy of combination of topical regimen (2% hydroquinone, 1% hydrocortisone and 0.05% tretinoin) with serial glycolic acid peeling in the treatment of melasma in Indian patients. Forty Indian patients of moderate to severe epidermal variety melasma were divided into two groups of 20 each. One Group i.e. peel group received topical regimen (2% hydroquinone, 1% hydrocortisone and 0.05% tretinoin) with serial glycolic acid peeling and other group i.e. control group received topical regimen (2% hydroquinone, 1% hydrocortisone, 0.05% tretinoin). There was an overall decrease in MASI from baseline in 24 weeks of therapy in both the groups (P value < 0.05). The group receiving the glycolic acid peel with topical regimen showed early and greater improvement than the group which was receiving topical regimen only. This study concluded that combining topical regimen (2% hydroquinone, 1% hydrocortisone and 0.05% tretinoin) with serial glycolic acid peeling significantly enhances the therapeutic efficacy of glycolic acid peeling. The combination of glycolic acid peeling with the topical regimen is a highly effective, safe and promising therapeutic option in treatment of melasma.

Formative assessment in the development of an obesity prevention component for the expanded food and nutrition education program in Texas.

PubMed

Thompson, Debbe; Cullen, Karen Weber; Reed, Debra B; Konzelmann, Karen; Smalling, Aggie Lara

2011-01-01

This study conducted formative research (surveys, focus groups) to assess the nutrition education needs of clients in the Texas Expanded Food and Nutrition Education Program prior to curriculum revision. Participants were current Expanded Food and Nutrition Education Program participants in 3 Texas cities (Austin, Houston, San Antonio). Data were used to tailor the curriculum to the target population. This research provides evidence that members of the target audience can provide valuable insights into a particular topic. Formative work prior to intervention development should be conducted to identify key issues regarding a particular topic and to evaluate potential educational approaches.

Option generation in decision making: ideation beyond memory retrieval

PubMed Central

Del Missier, Fabio; Visentini, Mimì; Mäntylä, Timo

2015-01-01

According to prescriptive decision theories, the generation of options for choice is a central aspect of decision making. A too narrow representation of the problem may indeed limit the opportunity to evaluate promising options. However, despite the theoretical and applied significance of this topic, the cognitive processes underlying option generation are still unclear. In particular, while a cued recall account of option generation emphasizes the role of memory and executive control, other theoretical proposals stress the importance of ideation processes based on various search and thinking processes. Unfortunately, relevant behavioral evidence on the cognitive processes underlying option generation is scattered and inconclusive. In order to reach a better understanding, we carried out an individual-differences study employing a wide array of cognitive predictors, including measures of episodic memory, semantic memory, cognitive control, and ideation fluency. The criterion tasks consisted of three different poorly-structured decision-making scenarios, and the participants were asked to generate options to solve these problems. The main criterion variable of the study was the number of valid options generated, but also the diversity and the quality of generated options were examined. The results showed that option generation fluency and diversity in the context of ill-structured decision making are supported by ideation ability even after taking into account the effects of individual differences in several other aspects of cognitive functioning. Thus, ideation processes, possibly supported by search and thinking processes, seem to contribute to option generation beyond basic associative memory retrieval. The findings of the study also indicate that generating more options may have multifaceted consequences for choice, increasing the quality of the best option generated but decreasing the mean quality of the options in the generated set. PMID:25657628

Option generation in decision making: ideation beyond memory retrieval.

PubMed

Del Missier, Fabio; Visentini, Mimì; Mäntylä, Timo

2014-01-01

According to prescriptive decision theories, the generation of options for choice is a central aspect of decision making. A too narrow representation of the problem may indeed limit the opportunity to evaluate promising options. However, despite the theoretical and applied significance of this topic, the cognitive processes underlying option generation are still unclear. In particular, while a cued recall account of option generation emphasizes the role of memory and executive control, other theoretical proposals stress the importance of ideation processes based on various search and thinking processes. Unfortunately, relevant behavioral evidence on the cognitive processes underlying option generation is scattered and inconclusive. In order to reach a better understanding, we carried out an individual-differences study employing a wide array of cognitive predictors, including measures of episodic memory, semantic memory, cognitive control, and ideation fluency. The criterion tasks consisted of three different poorly-structured decision-making scenarios, and the participants were asked to generate options to solve these problems. The main criterion variable of the study was the number of valid options generated, but also the diversity and the quality of generated options were examined. The results showed that option generation fluency and diversity in the context of ill-structured decision making are supported by ideation ability even after taking into account the effects of individual differences in several other aspects of cognitive functioning. Thus, ideation processes, possibly supported by search and thinking processes, seem to contribute to option generation beyond basic associative memory retrieval. The findings of the study also indicate that generating more options may have multifaceted consequences for choice, increasing the quality of the best option generated but decreasing the mean quality of the options in the generated set.

Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 mice.

PubMed

Lu, Yao-Ping; Lou, You-Rong; Xie, Jian-Guo; Peng, Qing-Yun; Zhou, Sherry; Lin, Yong; Shih, Weichung Joe; Conney, Allan H

2007-01-01

Topical application of caffeine sodium benzoate (caffeine-SB) immediately after UVB irradiation of SKH-1 mice enhanced UVB-induced apoptosis by a 2- to 3-fold greater extent than occurred after the topical application of an equimolar amount of caffeine. Although topical application of caffeine-SB or caffeine enhanced UVB-induced apoptosis, both substances were inactive on non-UVB-treated normal skin. Topical application of caffeine-SB or caffeine (each has UVB absorption properties) 0.5 h before irradiation with a high dose of UVB decreased UVB-induced thymine dimer formation and sunburn lesions (sunscreen effect). Caffeine-SB was more active than an equimolar amount of caffeine in exerting a sunscreen effect. In additional studies, caffeine-SB strongly inhibited the formation of tumors in UVB-pretreated 'high-risk mice' and in tumor-bearing mice, and the growth of UVB-induced tumors was also inhibited. Caffeine-SB and caffeine are the first examples of compounds that have both a sunscreen effect and enhance UVB-induced apoptosis. Our studies suggest that caffeine-SB and caffeine may be good agents for inhibiting the formation of sunlight-induced skin cancer.

Mechanical valve obstruction: Review of diagnostic and treatment strategies

PubMed Central

Salamon, Jason; Munoz-Mendoza, Jerson; Liebelt, Jared J; Taub, Cynthia C

2015-01-01

Prosthetic valve obstruction (PVO) is a rare but feared complication of mechanical valve replacement. Diagnostic evaluation should focus on differentiating prosthetic valve thrombosis (PVT) from pannus formation, as their treatment options differ. History of sub-optimal anti-coagulation and post-op time course to development of PVO are useful clinical characteristics in differentiating thrombus from pannus formation. Treatment of PVT is influenced by the patient’s symptoms, valve location, degree of obstruction and thrombus size and may include thrombolysis or surgical intervention. Alternatively, pannus formation requires surgical intervention. The purpose of this article is to review the pathophysiology, epidemiology, diagnostic approach and treatment options for aortic and mitral valve PVO. PMID:26730292

Americans in Middle Years: Career Options and Educational Opportunities.

ERIC Educational Resources Information Center

Entine, Alan D., Ed.

Twelve papers address three topics: the middle years--dimensions and dilemmas; the middle years--suggestions and solutions; and the changing university--new audiences for learning. Bruce Dearing examines personal, human questions posed by maturing individuals and indicates how they present challenges for a lifetime learning process. Bentley Glass…

Educational Equity Options. A Resource Bibliography.

ERIC Educational Resources Information Center

Martino, Susan; Watson, Jennifer

This selected list of educational resources includes 44 video items, 23 books, 9 posters, and 24 educational equity organizations and resource centers. Video materials and books are classified according to appropriate age groups and student abilities. All items are annotated. Topics of the videos and books include career choices, special needs…

Managed Care: A Primer on Issues and Legislation.

ERIC Educational Resources Information Center

American Counseling Association, Office of Public Policy and Information, Alexandria, VA.

This report is designed to familiarize American Counseling Association members with the concepts and terminology of managed care, and the various options for regulating managed care to safeguard the interests and rights of professional counselors and their clients. Topics covered in this report include controlling costs, private sector oversight,…

Space station needs, attributes and architectural options study. Volume 7-1: Data book. Science and applications missions

NASA Technical Reports Server (NTRS)

1983-01-01

User requirements for space station use are presented for the following areas: space environments, astrophysics, Earth observations, and life science. Also included are a summary of study tasks and final reports, a topical cross reference, key team members, and acronyms and abbreviations.

75 FR 6202 - Notice of Open Meeting of the Environmental Financial Advisory Board (EFAB)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... funding environmental programs, projects, and activities. The purpose of the meeting is to hear from... progress with work projects under EFAB's current Strategic Action Agenda. Environmental Finance topics... Reduction; Innovative Financing Tools, and State Revolving Fund Investment Options. The meeting is open to...

Net carbon uptake by establishing biofuel crops in Central Illinois

USDA-ARS?s Scientific Manuscript database

Clean and renewable sources of energy as wind, solar or biofuels comprise a valuable set of options available to deal with the pressing topics of energy security and mitigation of climate change effects. However, the efficiency in energy conversion and the environmental impacts of each new source of...

How To Manage the Emerging Generational Divide in the Contemporary Knowledge-Rich Workplace.

ERIC Educational Resources Information Center

Novicevic, Milorad M.; Buckley, M. Ronald

2001-01-01

Addresses the manager's dilemmas and options in resolving emerging latent intergenerational conflict in the contemporary knowledge-rich workplace. Topics include a theoretical framework for generational divide management; the polarization in task requirements; social and environmental factors; differences in employee needs and expectations; and…

Schools of Choice: Their Political Role in Gifted Education

ERIC Educational Resources Information Center

Kaplan, Sandra N.

2013-01-01

The concept of school choices has been historically referenced as options in educational philosophies, learning theories, curriculum designs, and program structures. Throughout time, "schools of choice" were defined by areas such as the Three Rs, the progressive movement of student-centered self-selected interest topics of study, classical…

Silvicultural options for neotropical migratory birds

Treesearch

Frank R. Thompson; John R. Probst; Martin G. Raphael

1993-01-01

We review: factors that affect forest bird populations; basic concepts of silvicultural systems; potential impacts of these systems on neotropical migratory birds (NTMBs); and conclude with management recommendations for integrating NTMB conservation with forest management. We approach this topic from a regional-landscape scale to a forest stand-habitat scale, rather...

Phase-change composites TES for nickel-hydrogen batteries

NASA Technical Reports Server (NTRS)

Knowles, Timothy R.; Meyer, Richard A.

1993-01-01

Viewgraphs of a discussion on phase-change composites thermal energy storage (TES) for nickel-hydrogen batteries are presented. Topics covered include Ni-H2 thermal control problems; passive thermal control with TES; phase-change composites (PCC); candidate materials; design options; fabrication and freeze-melt cycling; thermal modeling; system benefits; and applications.

Comment on "Life cycle comparison of environmental emissions from three disposal options for unused pharmaceuticals"

EPA Science Inventory

The disposal of unwanted, leftover medications is a topic of national concern. This product is a commentary on a paper in Environmental Science & Technology (doi:10.1021/es203987b) that makes an imprudent, hazardous recommendation regarding the disposal of unwanted drugs to dome...

ESL Writing Assessment Prompts: How Students Choose.

ERIC Educational Resources Information Center

Polio, Charlene; Glew, Margo

1996-01-01

Examines how English-as-a-Second-Language (ESL) students choose a prompt from several options on a timed-writing exam. Researchers interviewed 26 students after observing them taking a writing exam. Findings indicate that students' background knowledge, question type, and topic specificity influence their decision and that time is not an…

CTIC Cablebooks. Volume 2: A Guide for Local Policy.

ERIC Educational Resources Information Center

Jesuale, Nancy, Ed.; And Others

The second in a two-part series, this volume presents 13 chapters discussing many of the most pressing cable policy issues facing local government, describing alternative policy options, and suggesting regulatory procedures successfully used by decision makers in the United States. Topics covered are (1) "The Rationale for Regulation,"…

An Abnormal Psychology Community Based Interview Assignment

ERIC Educational Resources Information Center

White, Geoffry D.

1977-01-01

A course option in abnormal psychology involves students in interviewing and observing the activities of individuals in the off-campus community who are concerned with some aspect of abnormal psychology. The technique generates student interest in the field when they interview people about topics such as drug abuse, transsexualism, and abuse of…

Eco-efficiency assessment of options for metal recovery from incineration residues: a conceptual framework.

PubMed

Meylan, Grégoire; Spoerri, Andy

2014-01-01

Residues from municipal solid waste (MSW) incineration in Switzerland have been a hot topic in recent years, both in the research and practice communities. Regarded by many as an economically and environmentally sound solution to this issue, technological retrofitting of existing grate incinerators has the dual purpose of enhancing the metal recovery of bottom and fly ashes and improving the inertization of residues to be landfilled. How does context influence the economic and environmental performance of this particular technological option? Under which conditions would this technological option be implemented nationwide in the future? What are stakeholders' views on sustainable transitions of MSW incineration? We propose a three-stage methodological procedure to address these questions. Copyright © 2013 Elsevier Ltd. All rights reserved.

Portable power supply options for positive airway pressure devices.

PubMed

Riaz, Muhammad; Certal, Victor; Camacho, Macario

2015-01-01

Patients with obstructive sleep apnea (OSA) often face the challenge of how to power their positive airway pressure (PAP) devices when alternating current power supplies are not available in remote areas with lack of electricity or frequent power outages. This article elucidates portable power supply options for PAP devices with the aim to increase alternative power source awareness among medical providers. A search of scientific databases (Medline, Scopus, Web of Science, Google Scholar, and the Cochrane Library) was carried out on the topic of alternative portable power supply options for treatment of OSA. Scientific databases listed above yielded only limited results. Most articles were found via Google search. These articles were reviewed for alternative power supply options for OSA patients when alternating current is not available. The power supply options in this article include lead-acid batteries (starter, marine and deep-cycle batteries), lithium ion batteries, solar kits, battery packs, backup power systems, portable generators, and travel-size PAP devices. There are several options to power PAP devices with direct current when alternating current is not available. Knowledgeable primary care physicians especially in rural and remote areas can help OSA patients improve PAP compliance in order to mitigate morbidity and long-term complications of OSA.

Response threshold variance as a basis of collective rationality

PubMed Central

Yamamoto, Tatsuhiro

2017-01-01

Determining the optimal choice among multiple options is necessary in various situations, and the collective rationality of groups has recently become a major topic of interest. Social insects are thought to make such optimal choices by collecting individuals' responses relating to an option's value (=a quality-graded response). However, this behaviour cannot explain the collective rationality of brains because neurons can make only ‘yes/no’ responses on the basis of the response threshold. Here, we elucidate the basic mechanism underlying the collective rationality of such simple units and show that an ant species uses this mechanism. A larger number of units respond ‘yes’ to the best option available to a collective decision-maker using only the yes/no mechanism; thus, the best option is always selected by majority decision. Colonies of the ant Myrmica kotokui preferred the better option in a binary choice experiment. The preference of a colony was demonstrated by the workers, which exhibited variable thresholds between two options' qualities. Our results demonstrate how a collective decision-maker comprising simple yes/no judgement units achieves collective rationality without using quality-graded responses. This mechanism has broad applicability to collective decision-making in brain neurons, swarm robotics and human societies. PMID:28484636

Response threshold variance as a basis of collective rationality.

PubMed

Yamamoto, Tatsuhiro; Hasegawa, Eisuke

2017-04-01

Determining the optimal choice among multiple options is necessary in various situations, and the collective rationality of groups has recently become a major topic of interest. Social insects are thought to make such optimal choices by collecting individuals' responses relating to an option's value (=a quality-graded response). However, this behaviour cannot explain the collective rationality of brains because neurons can make only 'yes/no' responses on the basis of the response threshold. Here, we elucidate the basic mechanism underlying the collective rationality of such simple units and show that an ant species uses this mechanism. A larger number of units respond 'yes' to the best option available to a collective decision-maker using only the yes/no mechanism; thus, the best option is always selected by majority decision. Colonies of the ant Myrmica kotokui preferred the better option in a binary choice experiment. The preference of a colony was demonstrated by the workers, which exhibited variable thresholds between two options' qualities. Our results demonstrate how a collective decision-maker comprising simple yes/no judgement units achieves collective rationality without using quality-graded responses. This mechanism has broad applicability to collective decision-making in brain neurons, swarm robotics and human societies.

Current topics in shock waves; Proceedings of the International Symposium on Shock Waves and Shock Tubes, 17th, Lehigh University, Bethlehem, PA, July 17-21, 1989

NASA Astrophysics Data System (ADS)

Kim, Yong W.

Various papers on shock waves are presented. The general topics addressed include: shock formation, focusing, and implosion; shock reflection and diffraction; turbulence; laser-produced plasmas and waves; ionization and shock-plasma interaction; chemical kinetics, pyrolysis, and soot formation; experimental facilities, techniques, and applications; ignition of detonation and combustion; particle entrainment and shock propagation through particle suspension; boundary layers and blast simulation; computational methods and numerical simulation.

Cognitive and Affective Aspects of Creative Option Generation in Everyday Life Situations

PubMed Central

Schweizer, T. Sophie; Schmalenberger, Katja M.; Eisenlohr-Moul, Tory A.; Mojzisch, Andreas; Kaiser, Stefan; Funke, Joachim

2016-01-01

Which factors influence a human being’s ability to develop new perspectives and be creative? This ability is pivotal for any context in which new cognitions are required, such as innovative endeavors in science and art, or psychotherapeutic settings. In this article, we seek to bring together two research programs investigating the generation of creative options: On the one hand, research on option generation in the decision-making literature and, on the other hand, cognitive and clinical creativity research. Previous decision-making research has largely neglected the topic of generating creative options. Experiments typically provided participants with a clear set of options to choose from, but everyday life situations are less structured and allow countless ways to react. Before choosing an option, agents have to self-generate a set of options to choose from. Such option generation processes have only recently moved to the center of attention. The present study examines the creative quality of self-generated options in daily life situations. A student sample (N = 48) generated options for action in 70 briefly described everyday life scenarios. We rated the quality of the options on three dimensions of creativity- originality, feasibility, and divergence -and linked these qualities to option generation fluency (speed and number of generated options), situational features like the familiarity and the affective valence of the situation in which the options were generated, and trait measures of cognitive performance. We found that when situations were familiar to the participant, greater negative affective valence of the situation was associated with more originality and divergence of generated options. We also found that a higher option generation fluency was associated with a greater maximal originality of options. We complete our article with a joint research agenda for researchers in the decision-making field focusing on option generation and, on the other hand, researchers working on the cognitive and clinical aspects of creativity. PMID:27536258

Cognitive and Affective Aspects of Creative Option Generation in Everyday Life Situations.

PubMed

Schweizer, T Sophie; Schmalenberger, Katja M; Eisenlohr-Moul, Tory A; Mojzisch, Andreas; Kaiser, Stefan; Funke, Joachim

2016-01-01

Which factors influence a human being's ability to develop new perspectives and be creative? This ability is pivotal for any context in which new cognitions are required, such as innovative endeavors in science and art, or psychotherapeutic settings. In this article, we seek to bring together two research programs investigating the generation of creative options: On the one hand, research on option generation in the decision-making literature and, on the other hand, cognitive and clinical creativity research. Previous decision-making research has largely neglected the topic of generating creative options. Experiments typically provided participants with a clear set of options to choose from, but everyday life situations are less structured and allow countless ways to react. Before choosing an option, agents have to self-generate a set of options to choose from. Such option generation processes have only recently moved to the center of attention. The present study examines the creative quality of self-generated options in daily life situations. A student sample (N = 48) generated options for action in 70 briefly described everyday life scenarios. We rated the quality of the options on three dimensions of creativity- originality, feasibility, and divergence -and linked these qualities to option generation fluency (speed and number of generated options), situational features like the familiarity and the affective valence of the situation in which the options were generated, and trait measures of cognitive performance. We found that when situations were familiar to the participant, greater negative affective valence of the situation was associated with more originality and divergence of generated options. We also found that a higher option generation fluency was associated with a greater maximal originality of options. We complete our article with a joint research agenda for researchers in the decision-making field focusing on option generation and, on the other hand, researchers working on the cognitive and clinical aspects of creativity.

Crisaborole and its potential role in treating atopic dermatitis: overview of early clinical studies.

PubMed

Zane, L T; Chanda, S; Jarnagin, K; Nelson, D B; Spelman, L; Gold, Lf Stein

2016-07-01

Atopic dermatitis (AD), a chronic, relapsing, inflammatory skin disease that is characterized by intense pruritus and eczematous lesions with up to 90% of patients presenting with mild to moderate disease. Current topical treatments for AD have not changed in over 15 years and are associated with safety concerns. In AD, overactivity of phosphodiesterase 4 (PDE4), leads to inflammation and disease exacerbation. Crisaborole Topical Ointment, 2%, is a novel, nonsteroidal, topical anti-inflammatory PDE4 inhibitor currently being investigated for the treatment of mild to moderate AD. Preliminary studies in children and adults demonstrated favorable efficacy and safety profiles. Crisaborole may represent an anti-inflammatory option that safely minimizes the symptoms and severity of AD and that can be used for both acute and long-term management.

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo.

PubMed

Jacobino, Shamir R; Nederend, Maaike; Reijneveld, J Frederiek; Augustijn, Daan; Jansen, J H Marco; Meeldijk, Jan; Reiding, Karli R; Wuhrer, Manfred; Coenjaerts, Frank E J; Hack, C Erik; Bont, Louis J; Leusen, Jeanette H W

2018-04-01

Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization and mortality in young children. Protective therapy options are limited. Currently, palivizumab, a monoclonal IgG1 antibody, is the only licensed drug for RSV prophylaxis, although other IgG antibody candidates are being evaluated. However, at the respiratory mucosa, IgA antibodies are most abundant and act as the first line of defense against invading pathogens. Therefore, it would be logical to explore the potential of recombinant human IgA antibodies to protect against viral respiratory infection, but very little research on the topic has been published. Moreover, it is unknown whether human antibodies of the IgA isotype are better suited than those of the IgG isotype as antiviral drugs to combat respiratory infections. To address this, we generated various human IgA antibody formats of palivizumab and motavizumab, two well-characterized human IgG1 anti-RSV antibodies. We evaluated their efficacy to prevent RSV infection in vitro and in vivo and found similar, but somewhat decreased efficacy for different IgA subclasses and formats. Thus, reformatting palivizumab or motavizumab into IgA reduces the antiviral potency of either antibody. Moreover, our results indicate that the efficacy of intranasal IgA prophylaxis against RSV infection in human FcαRI transgenic mice is independent of Fc receptor expression.

"Straitjacket" or "Springboard for Sustainable Learning"? The Implications of Formative Assessment Practices in Vocational Learning Cultures

ERIC Educational Resources Information Center

Davies, Jenifer; Ecclestone, Kathryn

2008-01-01

In contrast to theoretical and empirical insights from research into formative assessment in compulsory schooling, understanding the relationship between formative assessment, motivation and learning in vocational education has been a topic neglected by researchers. The Improving Formative Assessment project (IFA) addresses this gap, using a…

Workshop I: Systems/Standards/Arrays

NASA Technical Reports Server (NTRS)

Piszczor, Mike; Reed, Brad

2007-01-01

Workshop Format: 1) 1:00 - 3:00 to cover various topics as appropriate; 2) At last SPRAT, conducted Workshop topic on solar cell and array qualification standards. Brad Reed will present update on status of that effort; 3) Second workshop topic: The Future of PV Research within NASA. 4) Any time remaining, specific topics from participants. 5) Reminder for IAPG Members! RECWG today 3:00-5:00 in Federal Room, 2nd Floor OAI. a chart is presented showing: Evaluation of Solar Array Technology Readiness Levels.

High time for a change: psychometric analysis of multiple-choice questions in nursing.

PubMed

Redmond, Sandra P; Hartigan-Rogers, Jackie A; Cobbett, Shelley

2012-11-26

Nurse educators teach students to develop an informed nursing practice but can educators claim the same grounding in the available evidence when formulating multiple-choice assessment tools to evaluate student learning? Multiple-choice questions are a popular assessment format within nursing education. While widely accepted as a credible format to assess student knowledge across disciplines, debate exists among educators regarding the number of options necessary to adequately test cognitive reasoning and optimal discrimination between student abilities. The purpose of this quasi-experimental between groups study was to examine the psychometric properties of three option multiple-choice questions when compared to the more traditional four option questions. Data analysis revealed that there were no statistically significant differences in the item discrimination, difficulty or the mean examination scores when multiple-choice test questions were administered with three versus four option answer choices. This study provides additional guidance for nurse educators to assist in improving multiple-choice question writing and test design.

Nuclear Engine System Simulation (NESS). Version 2.0: Program user's guide

NASA Technical Reports Server (NTRS)

Pelaccio, Dennis G.; Scheil, Christine M.; Petrosky, Lyman

1993-01-01

This Program User's Guide discusses the Nuclear Thermal Propulsion (NTP) engine system design features and capabilities modeled in the Nuclear Engine System Simulation (NESS): Version 2.0 program (referred to as NESS throughout the remainder of this document), as well as its operation. NESS was upgraded to include many new modeling capabilities not available in the original version delivered to NASA LeRC in Dec. 1991, NESS's new features include the following: (1) an improved input format; (2) an advanced solid-core NERVA-type reactor system model (ENABLER 2); (3) a bleed-cycle engine system option; (4) an axial-turbopump design option; (5) an automated pump-out turbopump assembly sizing option; (6) an off-design gas generator engine cycle design option; (7) updated hydrogen properties; (8) an improved output format; and (9) personal computer operation capability. Sample design cases are presented in the user's guide that demonstrate many of the new features associated with this upgraded version of NESS, as well as design modeling features associated with the original version of NESS.

Lookback Option Pricing with Fixed Proportional Transaction Costs under Fractional Brownian Motion.

PubMed

Sun, Jiao-Jiao; Zhou, Shengwu; Zhang, Yan; Han, Miao; Wang, Fei

2014-01-01

The pricing problem of lookback option with a fixed proportion of transaction costs is investigated when the underlying asset price follows a fractional Brownian motion process. Firstly, using Leland's hedging method a partial differential equation satisfied by the value of the lookback option is derived. Then we obtain its numerical solution by constructing a Crank-Nicolson format. Finally, the effectiveness of the proposed form is verified through a numerical example. Meanwhile, the impact of transaction cost rate and volatility on lookback option value is discussed.

Lookback Option Pricing with Fixed Proportional Transaction Costs under Fractional Brownian Motion

PubMed Central

Sun, Jiao-Jiao; Zhou, Shengwu; Zhang, Yan; Han, Miao; Wang, Fei

2014-01-01

The pricing problem of lookback option with a fixed proportion of transaction costs is investigated when the underlying asset price follows a fractional Brownian motion process. Firstly, using Leland's hedging method a partial differential equation satisfied by the value of the lookback option is derived. Then we obtain its numerical solution by constructing a Crank-Nicolson format. Finally, the effectiveness of the proposed form is verified through a numerical example. Meanwhile, the impact of transaction cost rate and volatility on lookback option value is discussed. PMID:27433525

Genital Bowen's Disease in a Bulgarian Patient: Complete Remission after Surgical Approach.

PubMed

Tchernev, Georgi; Lotti, Torello; Wollina, Uwe; Gianfaldoni, Serena; Lozev, Ilia; Lotti, Jacopo; França, Katlein; Batashki, Atanas; Chokoeva, Anastasiya

2017-07-25

A 60-year-old male patient presented with complaints of persistent red to a brown-colored plaque on his scrotum, with duration of approximately three years. The patient had been treated with oral and topical antifungals for inguinal tinea for several months and after that with topical corticosteroids for eczema for several more months. None of the regimens achieved any therapeutic effect. The histopathological evaluation revealed the presence of atypical keratinocytes in all layers of the epidermis with the altered epidermal pattern, spread parabasal mitotic activity, without secondary satellites, multiple dyskeratotic cells and multinucleated cells. The diagnosis of an intraepithelial non-invasive squamous cell carcinoma, associated with koilocytic dysplasia and hyperplasia was made, meeting the criteria for Bowen disease. An elliptic surgical excision of the lesion was made, while the defect was closed with single stitches, with excellent therapeutic and aesthetic result. First described by John T. Bowen in 1912, Bowen disease (BD) represents a squamous cell carcinoma (SCC) in situ with the potential for significant lateral spread. Treatment options include the application of topical 5-flurorouracil cream - useful in non-hairy areas, imiquimod cream or destructive methods such as radiation, curettage, cryotherapy, laser ablation and photodynamic therapy, especially useful in nail bed involvement. Despite the early lesions, surgical excision is the preferred treatment option, regarding the potential malignant transformation risk.

Topical Drug Delivery for Chronic Rhinosinusitis

PubMed Central

Liang, Jonathan; Lane, Andrew P.

2013-01-01

Chronic rhinosinusitis is a multifactorial disorder that may be heterogeneous in presentation and clinical course. While the introduction of endoscopic sinus surgery revolutionized surgical management and has led to significantly improved patient outcomes, medical therapy remains the foundation of long-term care of chronic rhinosinusitis, particularly in surgically recalcitrant cases. A variety of devices and pharmaceutical agents have been developed to apply topical medical therapy to the sinuses, taking advantage of the access provided by endoscopic surgery. The goal of topical therapy is to address the inflammation, infection, and mucociliary dysfunction that underlies the disease. Major factors that impact success include the patient’s sinus anatomy and the dynamics of the delivery device. Despite a growing number of topical treatment options, the evidence-based literature to support their use is limited. In this article, we comprehensively review current delivery methods and the available topical agents. We also discuss biotechnological advances that promise enhanced delivery in the future, and evolving pharmacotherapeutical compounds that may be added to rhinologist’s armamentarium. A complete understand of topical drug delivery is increasingly essential to the management of chronic rhinosinusitis when traditional forms of medical therapy and surgery have failed. PMID:23525506

Combination treatment of oral terbinafine with topical terbinafine and 10% urea ointment in hyperkeratotic type tinea pedis.

PubMed

Shi, Tian-Wei; Zhang, Jiang-An; Zhang, Xian-Wei; Yu, Hong-Xing; Tang, Yong-Bo; Yu, Jian-Bin

2014-09-01

Hyperkeratotic-type tinea pedis is chronic and recalcitrant to topical antifungal agents. Some topical antifungal agents are effective; however, long duration of therapy is required, which often reduce the treatment compliance of patients. To seek for short period therapy of hyperkeratotic type tinea pedis, in this study, we observed the efficacy and safety of treatment of topical terbinafine and 10% urea ointment combined oral terbinafine. Participants with hyperkeratotic type tinea pedis were randomly assigned to two groups. Patients in group I were treated with oral terbinafine for 2 weeks and topical terbinafine and 10% urea ointment for 4 weeks, whereas in group II, only the above topical agents were applied for 12 weeks. Clinical improvement rates and fungal eradication rates were compared between the two groups at 24 weeks after the initiation of treatment. The group I had stopped the topical therapy 8 weeks earlier than group II. There were no significant differences in mycological eradication rates and clinical improvement rates between the two groups, besides, no major side effects were noted in both groups. The short combination therapy with oral terbinafine was effective and safe; it should be a valuable option for patients with hyperkeratotic type tinea pedis. © 2014 Blackwell Verlag GmbH.

Prospective pilot study on combined use of pulsed dye laser and 1% topical rapamycin for treatment of nonfacial cutaneous capillary malformation.

PubMed

Doh, Eun Jin; Ohn, Jungyoon; Kim, Min Ji; Kim, Young Gull; Cho, Soyun

2017-11-01

The regeneration or revascularization of blood vessels after pulsed dye laser (PDL) treatment is one of the causes of treatment failures of cutaneous capillary malformations (CM). Recently, topical administration of rapamycin was introduced as a possible adjunctive therapeutic option to minimize postlaser revascularization in facial CM. We evaluated the effect of combined use of 1% topical rapamycin with PDL compared to PDL alone in cutaneous CM of trunk or extremities and tried to identify the optimal duration of topical rapamycin application. Three adjacent areas of cutaneous CM that had never been treated before were selected in each patient and underwent the following regimens: (A) PDL + vehicle for 8 weeks post-PDL; (B) PDL + topical rapamycin for 1-week post-PDL and (C) PDL + topical rapamycin for 8 weeks post-PDL. Each test site was treated by PDL for two sessions with 8 weeks interval. Only one of six patients showed clinical improvement with combined rapamycin treatment. Overall, there was no statistically significant difference in erythema and blanching rate among PDL alone and combined rapamycin regimens. One percent topical rapamycin does not seem to be effective as a treatment modality for cutaneous CM of trunk or extremities.

PICTURE PERFECT: IN DEPTH LOOK AT THE PICTURE FORMAT

EPA Science Inventory

SAS PICTURE format is a very powerful tool. The different options allow the display of data in a more picturesque manner adding symbols, qualifiers, and comments to the data points without modifying the data. With a PICTURE format one can create a series of templates for displa...

PICTURE PERFECT: IN DEPTH LOOK AT THE PICTURE FORMAT

EPA Science Inventory

SAS picture format is a very powerful tool. The different options allow the display of data in a more picturesque manner adding symbols, qualifiers, and comments to the data points without modifying the data. With a picture format one can create a series of templates for displ...

Optimizing topical therapies for treating psoriasis: a consensus conference.

PubMed

Zeichner, Joshua A; Lebwohl, Mark G; Menter, Alan; Bagel, Jerry; Del Rosso, James Q; Elewski, Boni E; Feldman, Steven R; Kircik, Leon H; Koo, John; Gold, Linda Stein; Tanghetti, Emil

2010-09-01

In 2010, an expert committee of physicians and researchers in the field of dermatology working together as the Psoriasis Process of Care Consensus Panel developed consensus guidelines for the treatment of psoriasis. As much as possible, the guidelines were evidence based but also included the extensive clinical experience of the dermatologists. Psoriasis is a lifelong disease that requires long-term treatment and 80% of psoriasis patients have mild to moderate disease. Topical therapies play an important role in the treatment of psoriasis, especially in patients with mild to moderate disease. Patients usually start with monotherapy; however, in more severe cases (> 10% body surface area [BSA], severely impaired quality of life [QOL], or recalcitrant psoriatic lesions), multiple treatment modalities may be used as part of combination, sequential, or rotational therapeutic regimens. Main treatment options include topical steroids, systemic therapies, topical vitamin D treatments such as vitamin D3 ointment, retinoids, phototherapy, and biologic therapies. Other topical therapies include the following steroid-sparing agents: coal tar, anthralin, calcineurin inhibitors, keratolytics, and emollients. Therapeutic considerations also should focus on adherence, improving QOL, and promoting a good patient-physician relationship.

Topical treatment of glaucoma: established and emerging pharmacology.

PubMed

Dikopf, Mark S; Vajaranant, Thasarat S; Edward, Deepak P

2017-06-01

Glaucoma is a collection of optic neuropathies consisting of retinal ganglion cell death and corresponding visual field loss. Glaucoma is the leading cause of irreversible vision loss worldwide and is forecasted to precipitously increase in prevalence in the coming decades. Current treatment options aim to lower intraocular pressure (IOP) via topical or oral therapy, laser treatment to the trabecular meshwork or ciliary body, and incisional surgery. Despite increasing use of trabecular laser therapy, topical therapy remains first-line in the treatment of most forms of glaucoma. Areas covered: Novel glaucoma therapies are a long-standing focus of investigational study. More than two decades have passed since the last United States Food and Drug Administration (FDA) approval of a topical glaucoma drug. Here, the authors review established topical glaucoma drops as well as those currently in FDA phase 2 and 3 clinical trial, nearing clinical use. Expert opinion: Current investigational glaucoma drugs lower IOP, mainly through enhanced trabecular meshwork outflow. Although few emerging therapies show evidence of retinal ganglion cell and optic nerve neuroprotection in animal models, emerging drugs are focused on lowering IOP, similar to established medicines.

Future perspectives on space psychology: Recommendations on psychosocial and neurobehavioural aspects of human spaceflight

NASA Astrophysics Data System (ADS)

De La Torre, Gabriel G.; van Baarsen, Berna; Ferlazzo, Fabio; Kanas, Nick; Weiss, Karine; Schneider, Stefan; Whiteley, Iya

2012-12-01

Recently the psychological effects of space flight have gained in attention. In uncovering the psychological challenges that individuals and teams can face, we need research options that integrate psychosocial aspects with behavioral, performance, technical and environmental issues. Future perspectives in Space Psychology and Human Spaceflight are reviewed in this paper. The topics covered include psychosocial and neurobehavioural aspects, neurocognitive testing tools, decision making, autonomy and delayed communications, well being, mental health, situational awareness, and methodology. Authors were members of a European Space Agency (ESA) Research Topical Team on Psychosocial and Behavioral Aspects of Human Spaceflight. They discuss the different topics under a common perspective of a theoretical and practical framework, showing interactions, relationships and possible solutions for the different aspects and variables in play. Recommendations for every topic are offered and summarized for future research in the field. The different proposed research ideas can be accomplished using analogs and simulation experiments, short- and long-duration bed rest, and in-flight microgravity studies. These topics are especially important for future Moon and Mars mission design and training.

Treatment adherence and real-life effectiveness of topical therapy in patients with mild or moderate psoriasis: uptake of scientific evidence in clinical practice and dermatologists' preferences for alternative treatment options.

PubMed

Neri, L; Miracapillo, A

2015-02-01

Topical corticosteroids and the vitamin D analogue calcipotriol are the cornerstone of therapy for patients with mild-to-moderate plaque psoriasis. Lack of patients' adherence leads to suboptimal effectiveness of topical therapy in real-life practice. The fixed combination betamethasone/calcipotriol gel is more effective and safe than the administration of single components and may enhance patients' adherence. We aimed at evaluating the pattern of care and dermatologists' expert opinion toward the available topical treatments for the management of mild-to-moderate psoriasis in Italy. We enrolled 242 Italian dermatologists and collected information related to their practice pattern and opinion toward available topical treatments with a face-to-face structured interview. We evaluated dermatologists' ratings of therapy with 16 items tapping their opinion toward the relevance and satisfaction toward 8 therapy attributes in clinical practices which tapped aspects of real-life effectiveness, adherence promotion, toxicity, convenience of use. Ratings occurred along a 10-point scale. We compared single-attribute and weighted overall therapy ratings across alternative treatment options with random-intercept linear models to account for ratings clustering within dermatologists. There was a wide variation in practice patterns: 1/3 of dermatologist had seen more than 30 patients with psoriasis while around 1/4 had seen less than 10 patients. The fixed combination betamethasone/calcipotriol gel was considered superior to monotherapies in all the eight attributes considered which tapped aspects of real-life effectiveness, adherence promotion, toxicity, convenience of use. Participant dermatologists' strongly preferred the fixed betamethasone/calcipotriol combination gel over both the fixed combination ointment formulation and corticosteroid or vitamin D analogues monotherapies. Such findings are in line with evidence from randomized controlled trials and few observational studies demonstrating superior clinical outcomes, quality of life, tolerability and lower risk of side effect in patients treated with the fixed combination of betamethasone/calcipotriol gel.

Premature ejaculation: do we have effective therapy?

PubMed

Serefoglu, Ege Can; Saitz, Theodore R; Trost, Landon; Hellstrom, Wayne J G

2013-03-01

Premature ejaculation (PE) is the most common sexual dysfunction, with the majority of PE patients remaining undiagnosed and undertreated. Despite its prevalence, there is a current paucity of data regarding available treatment options and mechanisms. The objective of the current investigation is to review and summarize pertinent literature on therapeutic options for the treatment of PE, including behavioral/psychologic, oral pharmacotherapy, and surgery. A pubmed search was conducted on articles reporting data on available treatment options for PE. Articles describing potential mechanisms of action were additionally included for review. Preference was given towards randomized, controlled trials, when available. PE remains an underdiagnosed and undertreated disease process, with limited data available regarding potential underlying mechanisms and long-term outcomes of treatment options. Psychological/behavioral therapies, including the stop-start, squeeze, and pelvic floor rehabilitation techniques have demonstrated improvements in short-term series, with decreased efficacy with additional follow-up. Topical therapies, which are commonly utilized result in prolonged intravaginal ejaculatory latency time (IELT) at the expense of potential penile/vaginal Hypothesia. Oral therapies similarly demonstrate improved IELTs with variable side effect profiles and include selective serotonin reuptake inhibitors (daily or on demand), phosphodiesterase-5 inhibitors, alpha-1 adrenergic antagonists, and tramadol. Alternative therapies such as acupuncture have shown benefits in limited studies. Surgery is not commonly performed and is not recommended by available guidelines. PE is a common condition, with limited data available regarding its underlying pathophysiology and treatment. Available therapies include topical, oral, behavioral/psychologic modification, or a combination thereof. Additional research is required to assess the optimal treatment strategies and algorithms as well as to better define the mechanisms for PE and its management.

Premature ejaculation: do we have effective therapy?

PubMed Central

Serefoglu, Ege Can; Saitz, Theodore R.; Trost, Landon

2013-01-01

Introduction Premature ejaculation (PE) is the most common sexual dysfunction, with the majority of PE patients remaining undiagnosed and undertreated. Despite its prevalence, there is a current paucity of data regarding available treatment options and mechanisms. The objective of the current investigation is to review and summarize pertinent literature on therapeutic options for the treatment of PE, including behavioral/psychologic, oral pharmacotherapy, and surgery. Methods A pubmed search was conducted on articles reporting data on available treatment options for PE. Articles describing potential mechanisms of action were additionally included for review. Preference was given towards randomized, controlled trials, when available. Results PE remains an underdiagnosed and undertreated disease process, with limited data available regarding potential underlying mechanisms and long-term outcomes of treatment options. Psychological/behavioral therapies, including the stop-start, squeeze, and pelvic floor rehabilitation techniques have demonstrated improvements in short-term series, with decreased efficacy with additional follow-up. Topical therapies, which are commonly utilized result in prolonged intravaginal ejaculatory latency time (IELT) at the expense of potential penile/vaginal Hypothesia. Oral therapies similarly demonstrate improved IELTs with variable side effect profiles and include selective serotonin reuptake inhibitors (daily or on demand), phosphodiesterase-5 inhibitors, alpha-1 adrenergic antagonists, and tramadol. Alternative therapies such as acupuncture have shown benefits in limited studies. Surgery is not commonly performed and is not recommended by available guidelines. Conclusions PE is a common condition, with limited data available regarding its underlying pathophysiology and treatment. Available therapies include topical, oral, behavioral/psychologic modification, or a combination thereof. Additional research is required to assess the optimal treatment strategies and algorithms as well as to better define the mechanisms for PE and its management. PMID:26816723

[DNAStat, version 1.2 -- a software package for processing genetic profile databases and biostatistical calculations].

PubMed

Berent, Jarosław

2007-01-01

This paper presents the new DNAStat version 1.2 for processing genetic profile databases and biostatistical calculations. This new version contains, besides all the options of its predecessor 1.0, a calculation-results file export option in .xls format for Microsoft Office Excel, as well as the option of importing/exporting the population base of systems as .txt files for processing in Microsoft Notepad or EditPad

46 CFR 67.218 - Optional filing of instruments in portable document format as attachments to electronic mail.

Code of Federal Regulations, 2010 CFR

2010-10-01

... recording under § 67.200 may be submitted in portable document format (.pdf) as an attachment to electronic... submitted for filing in .pdf format pertains to a vessel that is not a currently documented vessel, a... with the National Vessel Documentation Center or must be submitted in .pdf format with the instrument...

Space station needs, attributes, and architectural options: Technology development

NASA Technical Reports Server (NTRS)

Robert, A. C.

1983-01-01

The technology development of the space station is examined as it relates to space station growth and equipment requirements for future missions. Future mission topics are refined and used to establish a systems data base. Technology for human factors engineering, space maintenance, satellite design, and laser communications and tracking is discussed.

Business Education Course Descriptions. Course Descriptions for the Improvement of Business Education.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Education, Oklahoma City.

Course descriptions are provided for 22 courses in the area of business education. Each description contains the following information: purpose, course objectives, outline of course content, list of optional topics, recommended types of evaluation, prerequisites, areas of interest, and curriculum sequence (grade level at which it should be…

Visualizing Molecular Chirality in the Organic Chemistry Laboratory Using Cholesteric Liquid Crystals

ERIC Educational Resources Information Center

Popova, Maia; Bretz, Stacey Lowery; Hartley, C. Scott

2016-01-01

Although stereochemistry is an important topic in second-year undergraduate organic chemistry, there are limited options for laboratory activities that allow direct visualization of macroscopic chiral phenomena. A novel, guided-inquiry experiment was developed that allows students to explore chirality in the context of cholesteric liquid crystals.…

Structuring an Undergraduate Mathematics Seminar Dealing with Options and Hedging

ERIC Educational Resources Information Center

Prevot, K. J.

2006-01-01

Offering mathematics majors the opportunity to engage in current, real-world applications can be an important enhancement to their undergraduate course curriculum. Instead of focusing on the traditional topic areas in pure and/or applied mathematics, one may structure a seminar course for senior mathematics majors by concentrating on a specific…

Measuring the Benefits of Examinee-Selected Questions

ERIC Educational Resources Information Center

Allen, Nancy L.; Holland, Paul W.; Thayer, Dorothy T.

2005-01-01

Allowing students to choose the question(s) that they will answer from among several possible alternatives is often viewed as a mechanism for increasing fairness in certain types of assessments. The fairness of optional topic choice is not a universally accepted fact, however, and various studies have been done to assess this question. We examine…

Physical Education, Part I. Options in Education, Program No. 99.

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC. Inst. for Educational Leadership.

This transcript of a National Public Radio broadcast discusses the impact of Title IX on elementary and secondary physical education. Topics covered include competition, difficulties involved in the sex integration of sports, statements on Title IX by five chief state school officers, the experience of Massachusetts in implementing Title IX, and…

The NTF as a national facility. [project planning

NASA Technical Reports Server (NTRS)

Nicks, O. W.

1977-01-01

Activities which led to the definition of the National Transonic Facility and the general agreements reached regarding its use and operations are reviewed. Topics discussed include: redefinition of test requirements, development of low cost options, consideration of a single transonic facility using existing hardware if feasible, facility concept recommendations, and acquisition schedule proposals.

Human Biology, High School Science Course Guide.

ERIC Educational Resources Information Center

Donovan, Edward P.; Prickitt, Ralph

A course in human biology was developed to increase course options for students of all abilities and interest levels who successfully completed 1 year of high school science. Major topic areas of the course include: general plan of the human body; causes, cures, and prevention of diseases; human body chemistry; structure and function of cells,…

Window Insulation: How to Sort Through the Options.

ERIC Educational Resources Information Center

Miller, Barbara

This two-part report explores the efforts of businesses and individuals to improve the thermal performance of windows. Part I discusses the basics of what makes a window product insulate or save energy. Topic areas addressed include saving energy lost through windows, key components of window insulation, three basic types of window insulation,…

Wilderness Education Association Affiliates and Service-Learning: Where Do They Stand?

ERIC Educational Resources Information Center

Poff, Raymond; Harris, Matthew; Spencer, Steve

2005-01-01

The purpose of this article is to report the findings of a study, conducted among Wilderness Education Association Affiliates, aimed at understanding the service-learning options provided. Several definitions and viewpoints regarding service-learning can be found throughout the literature; only a few are presented to introduce the topic. E-mails…

The Debate on Maturational Constraints in Bilingual Development: A Perspective from First-Language Attrition

ERIC Educational Resources Information Center

Schmid, Monika S.

2014-01-01

A controversial topic in research on second-language acquisition is whether residual variability and optionality in high-proficiency late second-language (L2) learners is merely the outcome of cross-linguistic transfer, competition, and processing limitations, or whether late learners have an underlying representational deficit due to maturational…

An Integrative Approach to Foreign Language Teaching: Choosing Among the Options. ACTFL Foreign Language Education Series, Vol. 8.

ERIC Educational Resources Information Center

Jarvis, Gilbert A., Ed.

This volume on foreign language teaching and learning concerns the following topics: lifelong learning, small-group learning, the minicourse, student attitudes toward foreign languages, problems in secondary schools, humanistic education, curricula in uncommonly taught languages, foreign languages in elementary and adolescent-centered education,…

Solar lunar power

NASA Technical Reports Server (NTRS)

Bailey, Sheila G.; Landis, Geoffrey A.

1994-01-01

Current and projected technology is assessed for photovoltaic power for a lunar base. The following topics are discussed: requirements for power during the lunar day and night; solar cell efficiencies, specific power, temperature sensitivity, and availability; storage options for the lunar night; array and system integration; the potential for in situ production of photovoltaic arrays and storage medium.

Industrial Arts Education Guide for Curriculum and Program Planning, Secondary Level.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of Occupational Education Curriculum Development.

Guidelines for the development of courses and programs of industrial arts for local school districts in New York State are provided in this guide designed for administrators, curriculum personnel, supervisors, and teachers. Following a discussion of student program options, a basic series of suggested courses (titles and course topics) are…

The Relationships between Logical Thinking, Gender, and Kinematics Graph Interpretation Skills

ERIC Educational Resources Information Center

Bektasli, Behzat; White, Arthur L.

2012-01-01

Problem Statement: Kinematics is one of the topics in physics where graphs are used broadly. Kinematics includes many abstract formulas, and students usually try to solve problems with those formulas. However, using a kinematics graph instead of formulas might be a better option for problem solving in kinematics. Graphs are abstract…

Space Station needs, attributes and architectural options study. Volume 7-4A: Data book, architecture, technology and programmatics, part A

NASA Technical Reports Server (NTRS)

1983-01-01

Various parameters of the orbital space station are discussed. The space station environment, data management system, communication and tracking, environmental control, and life support system are considered. Specific topics reviewed include crew work stations, restraint systems, stowage, computer hardware, and expert systems.

Stuttering in Preschool Children: Direct versus Indirect Treatment

ERIC Educational Resources Information Center

Nippold, Marilyn A.

2018-01-01

Purpose: The purpose of this article is to discuss the controversial topic of stuttering in preschool children and how to evaluate the options for treatment, emphasizing the role of external research evidence. Method: A hypothetical but realistic case study of a 3-year-old boy who stutters is described. Two contrasting approaches to treatment are…

Noninvasive extramammary Paget's disease treated with photodynamic therapy: case series from the Roswell Park Cancer Institute.

PubMed

Housel, Joseph P; Izikson, Leonid; Zeitouni, Nathalie C

2010-11-01

Extramammary Paget's disease (EMPD) is a rare low-grade cutaneous malignancy that affects apocrine gland-bearing areas and most commonly occurs on the perineal skin. Photodynamic therapy (PDT) may represent a useful treatment option for extensive, noninvasive EMPD, alone or as part of multimodal therapy. To analyze the clinical outcomes of PDT for noninvasive EMPD with topical aminolevulinic acid (ALA) or intravenous porfimer sodium as photosensitizing agents and argon laser as the photoactivator. Retrospective case series of patients with noninvasive EMPD treated at Roswell Park Cancer Institute with PDT from April 20, 1995, to December 4, 2008. Identified patients included five men and three women aged 50 to 80 (mean age 67) with a total of 24 distinct lesions of noninvasive EMPD without distant metastases. Four patients received topical ALA only as a photosensitizer, three received intravenous porfimer sodium only, and one received both. All patients were treated using a 632.8-nm argon-pumped dye laser, and some were also treated using a red lamp (590-729 nm). Seven of nine lesions (78%) treated with PDT using intravenous porfimer sodium showed a complete response (CR) and were disease free at 12 to 96 months. Eight of 16 lesions (50%) treated with PDT using topical ALA showed a CR, and 38% were disease free at 9 to 88 months. None of the treated patients developed any serious cosmetic or functional impairments, such as loss of sphincter control or dysesthesias. PDT with intravenous porfimer sodium or topical ALA and argon laser may represent a useful, surgery-sparing therapeutic option for management of noninvasive EMPD in selected patients. Prospective, randomized clinical trials are necessary to compare the effectiveness of PDT with that of surgery for noninvasive EMPD. © 2010 by the American Society for Dermatologic Surgery, Inc.

A Preliminary Analysis of College Students’ Preinstructional Ideas About Planet Formation

NASA Astrophysics Data System (ADS)

Simon, Molly; Impey, Chris David; Buxner, Sanlyn

2017-01-01

From as early as nursery school, children are taught about planet Earth and “our place in space.” Learning about the Solar System transcends K-12 education, and is considered one of the top-ten most frequently discussed topics in undergraduate introductory astronomy courses for non-majors. All too frequently, however, the discussion stops after a brief overview of each planet, and students are left to ponder how the Solar System came to be in the first place. The topic of planet formation has grown in importance in any astronomy class in light of the discovery of nearly 5,000 exoplanet candidates, where the properties of exoplanetary systems have cast light on the general process of planet formation. This highly active research field has been slow to be properly represented in the astronomy classroom for non-majors. For this work, we presented students in six undergraduate 100 and 200-level astronomy courses at the University of Arizona with one of three short answer questions on the topic of planet formation. The questions were administered on the first day of the Fall 2016 semester before any related material was taught. We will present an analysis of these responses, and discuss any common trends, themes, and misconceptions that appear from the dataset. These responses will lend to the development of the Planet Formation Concept Inventory (PFCI) that will be used by ASTR 101 instructors to evaluate students’ understanding of planet formation before and after instruction.

Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs.

PubMed

Murakami, S; Takayama, S; Kitamura, M; Shimabukuro, Y; Yanagi, K; Ikezawa, K; Saho, T; Nozaki, T; Okada, H

2003-02-01

Several growth factors (or cytokines) have been recently investigated for their use as potential therapeutics for periodontal tissue regeneration. The objective of this study was to evaluate periodontal tissue regeneration, including new bone and cementum formation, following topical application of recombinant basic fibroblast growth factor (bFGF, FGF-2) to furcation class II defects. Twelve furcation class II bone defects were surgically created in six beagle dogs, then recombinant bFGF (30 micro g/site) + gelatinous carrier was topically applied to the bony defects. Six weeks after application, periodontal regeneration was analyzed. In all sites where bFGF was applied, periodontal ligament formation with new cementum deposits and new bone formation was observed histomorphometrically, in amounts greater than in the control sites. Basic FGF-applied sites exhibited significant regeneration as represented by the new bone formation rate (NBR) (83.6 +/- 14.3%), new trabecular bone formation rate (NTBR) (44.1 +/- 9.5%), and new cementum formation rate (NCR) (97.0 +/- 7.5%). In contrast, in the carrier-only sites, the NBR, NTBR, and NCR were 35.4 +/- 8.9%, 16.6 +/- 6.2%, and 37.2 +/- 15.1%, respectively. Moreover, no instances of epithelial down growth, ankylosis, or root resorption were observed in the bFGF-applied sites examined. The present results indicate that topical application of bFGF can enhance considerable periodontal regeneration in artificially created furcation class II bone defects of beagle dogs.

Complex formation of sericoside with hydrophilic cyclodextrins: improvement of solubility and skin penetration in topical emulsion based formulations.

PubMed

Rode, T; Frauen, M; Müller, B W; Düsing, H J; Schönrock, U; Mundt, C; Wenck, H

2003-03-01

The main objective of this study was to devise novel methods for improving the solubility of the anti-inflammatory triterpenoid sericoside, the main component of Terminalia sericea extract, thus enabling its incorporation into topical formulations. Sericoside was stabilized by complex formation with hydrophilic derivatives of beta- and gamma-cyclodextrins in a molar ratio of 1.0:1.1. The complex of extract and cyclodextrin was equilibrated in water at 25 degrees C for approximately 24 h. The dehydrated complexes of T. sericea extract and cyclodextrin were characterized by differential scanning calorimetry, thermogravimetry analysis and X-ray diffraction. Complex formation with beta-cyclodextrin as well as gamma-cyclodextrin derivatives was detectable using these three analytical tools; however, only complexes with gamma-cyclodextrin derivatives showed stability upon storage after incorporation into topical o/w or w/o formulations. Furthermore, a T. sericea extract/gamma-cyclodextrin complex incorporated in an o/w formulation resulted in a 2.6-fold higher percutaneous penetration of sericoside in in vitro excised pig skin as compared to pure T. sericea extract. For the first time, the virtually insoluble anti-inflammatory active sericoside was incorporated into a topical emulsion based formulation in a stable manner, resulting in efficient skin penetration. Copyright 2003 Elsevier Science B.V.

Coordinating Demand-Side Efficiency Evaluation, Measurement and Verification Among Western States: Options for Documenting Energy and Non-Energy Impacts for the Power Sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schiller, Steven R.; Schwartz, Lisa C.

Demand-side energy efficiency (efficiency) represents a low-cost opportunity to reduce electricity consumption and demand and provide a wide range of non-energy benefits, including avoiding air pollution. Efficiency-related energy and non-energy impacts are determined and documented by implementing evaluation, measurement and verification (EM&V) systems. This technical brief describes efficiency EM&V coordination strategies that Western states can consider taking on together, outlines EM&V-related products that might be appropriate for multistate coordination, and identifies some implications of coordination. Coordinating efficiency EM&V activities can save both time and costs for state agencies and stakeholders engaged in efficiency activities and can be particularly beneficial formore » multiple states served by the same utility. First, the brief summarizes basic information on efficiency, its myriad potential benefits and EM&V for assessing those benefits. Second, the brief introduces the concept of multistate EM&V coordination in the context of assessing such benefits, including achievement of state and federal goals to reduce air pollutants.1 Next, the brief presents three coordination strategy options for efficiency EM&V: information clearinghouse/exchange, EM&V product development, and a regional energy efficiency tracking system platform. The brief then describes five regional EM&V products that could be developed on a multistate basis: EM&V reporting formats, database of consistent deemed electricity savings values, glossary of definitions and concepts, efficiency EM&V methodologies, and EM&V professional standards or accreditation processes. Finally, the brief discusses options for next steps that Western states can take to consider multistate coordination on efficiency EM&V. Appendices provide background information on efficiency and EM&V, as well as definitions and suggested resources on the covered topics. This brief is intended to inform state public utility commissions, boards for public and consumer-owned utilities, state energy offices and air agencies, and other organizations involved in discussions about the use of efficiency EM&V.« less

41 CFR 102-194.25 - What is an automated Standard or Optional format?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION ADMINISTRATIVE PROGRAMS 194-STANDARD AND OPTIONAL FORMS MANAGEMENT PROGRAM § 102-194.25 What is an automated Standard or... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is an automated...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, Andrew T.; Robinson, David Gerald

Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms suchmore » as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.« less

Proceedings of Small Power Systems Solar Electric Workshop. Volume 2: Invited papers

NASA Technical Reports Server (NTRS)

Ferber, R. (Editor)

1978-01-01

The focus of this work shop was to present the committment to the development of solar thermal power plants for a variety of applications including utility applications. Workshop activities included panel discussions, formal presentations, small group interactive discussions, question and answer periods, and informal gatherings. Discussion on topics include: (1) solar power technology options; (2) solar thermal power programs currently underway at the DOE, JPL, Electric Power Research Institute (EPRI), and Solar Energy Research Institute (SERI); (3) power options competing with solar; (4) institutional issues; (5) environmental and siting issues; (6) financial issues; (7) energy storage; (8) site requirements for experimental solar installations, and (9) utility planning.

The history and progression of treatments for allergic rhinitis.

PubMed

Ostrom, Nancy K

2014-01-01

This article intends to place new treatments in the context of allergic rhinitis (AR) treatment history. The medical literature was searched for significant advances and changes in AR treatment. Historical data on AR treatment options and management were selected. Reviews of AR management published throughout the 20th century were included to provide context for treatment advances. Modern AR treatment began in the early 20th century with immunotherapy and was soon followed by the emergence of antihistamine therapy in the 1930s. Numerous treatments for AR have been used over the ensuing decades, including decongestants, mast cell stabilizers, and leukotriene receptor antagonists. Topical corticosteroid options were developed the 1950s, and, added to baseline antihistamine therapy, became the foundation of AR treatment. Treatment options were significantly impacted after the 1987 Montreal Protocol, which phased out the use of chlorofluorocarbon propellant aerosols because of environmental concerns. From the mid-1990s until recently, this left only aqueous solution options for intranasal corticosteroids (INSs). The approval of the first hydrofluoroalkane propellant aerosol INSs for AR in 2012 restored a "dry" aerosol treatment option. The first combination intranasal antihistamine/INSs was also approved in 2012, providing a novel treatment option for AR. Treatment of AR has progressed with new therapeutic options now available. This should continue to move forward with agents to alter the allergic mechanism itself and impact the disease burden that has a significant impact on patient outcomes.

Objective structured clinical examination "Death Certificate" station - Computer-based versus conventional exam format.

PubMed

Biolik, A; Heide, S; Lessig, R; Hachmann, V; Stoevesandt, D; Kellner, J; Jäschke, C; Watzke, S

2018-04-01

One option for improving the quality of medical post mortem examinations is through intensified training of medical students, especially in countries where such a requirement exists regardless of the area of specialisation. For this reason, new teaching and learning methods on this topic have recently been introduced. These new approaches include e-learning modules or SkillsLab stations; one way to objectify the resultant learning outcomes is by means of the OSCE process. However, despite offering several advantages, this examination format also requires considerable resources, in particular in regards to medical examiners. For this reason, many clinical disciplines have already implemented computer-based OSCE examination formats. This study investigates whether the conventional exam format for the OSCE forensic "Death Certificate" station could be replaced with a computer-based approach in future. For this study, 123 students completed the OSCE "Death Certificate" station, using both a computer-based and conventional format, half starting with the Computer the other starting with the conventional approach in their OSCE rotation. Assignment of examination cases was random. The examination results for the two stations were compared and both overall results and the individual items of the exam checklist were analysed by means of inferential statistics. Following statistical analysis of examination cases of varying difficulty levels and correction of the repeated measures effect, the results of both examination formats appear to be comparable. Thus, in the descriptive item analysis, while there were some significant differences between the computer-based and conventional OSCE stations, these differences were not reflected in the overall results after a correction factor was applied (e.g. point deductions for assistance from the medical examiner was possible only at the conventional station). Thus, we demonstrate that the computer-based OSCE "Death Certificate" station is a cost-efficient and standardised format for examination that yields results comparable to those from a conventional format exam. Moreover, the examination results also indicate the need to optimize both the test itself (adjusting the degree of difficulty of the case vignettes) and the corresponding instructional and learning methods (including, for example, the use of computer programmes to complete the death certificate in small group formats in the SkillsLab). Copyright © 2018 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Microorganisms and methods for producing pyruvate, ethanol, and other compounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reed, Jennifer L.; Zhang, Xiaolin

Microorganisms comprising modifications for producing pyruvate, ethanol, and other compounds. The microorganisms comprise modifications that reduce or ablate activity of one or more of pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase, phosphate acetyltransferase, acetate kinase, pyruvate oxidase, lactate dehydrogenase, cytochrome terminal oxidase, succinate dehydrogenase, 6-phosphogluconate dehydrogenase, glutamate dehydrogenase, pyruvate formate lyase, pyruvate formate lyase activating enzyme, and isocitrate lyase. The microorganisms optionally comprise modifications that enhance expression or activity of pyruvate decarboxylase and alcohol dehydrogenase. The microorganisms are optionally evolved in defined media to enhance specific production of one or more compounds. Methods of producing compounds with the microorganisms are provided.

Treatment options for demodex blepharitis: patient choice and efficacy.

PubMed

Hirsch-Hoffmann, S; Kaufmann, C; Bänninger, P B; Thiel, M A

2015-04-01

Demodex mites are microscopic parasites that live around hair follicles or sebaceous glands and may cause chronic blepharitis. The aim of this outcome analysis was to assess the efficacy and patient preferences with regard to the currently recommended treatment options. All patients with microscopic evidence for Demodex blepharitis were informed about the currently published treatments and instructed about daily lid hygiene. Additional topical treatment options included tea tree oil (TTO) 5%, a cleansing foam containing 0.02% TTO (Naviblef®), and metronidazole 2% ointment. Systemic treatment options included oral ivermectin 6 mg on day 1 and 14 and metronidazole 500 mg twice daily for 10 days. All patients were reviewed after 2 months for symptoms and for a mite count on 10 epilated lashes. Ninety-four of 96 patients with Demodex blepharitis opted for an additional treatment. The mean mite count after 2 months of treatment were 13.3 with 5% TTO (n=6), 12.0 with 0.02% TTO (n=38), 9.4 with metronidazole ointment (n=5), 12.8 with ivermectin (n=27) and 22.0 with oral metronidazole (n=5). While there are several published treatment options available, none of these options seem to be clearly effective in Demodex blepharitis. Georg Thieme Verlag KG Stuttgart · New York.

Topical Conference on the Origin of the Earth

NASA Technical Reports Server (NTRS)

1988-01-01

The abstracts are presented on the topic of the origin of the Earth. The subject of planetary evolution from inner solar system plantesimals through the formation and composition of the Earth's atmosphere and the physical structure of the Earth and the Moon is explored in great variety.

OpenMPI and ExxonMobil Topics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hjelm, Nathan Thomas; Pritchard, Howard Porter

These are a series of slides for a presentation for ExxonMobil's visit to Los Alamos National Laboratory. Topics covered are: Open MPI - The Release Story, MPI-3 RMA in Open MPI, MPI dynamic process management and Open MPI, and new options with CLE 6. Open MPI RMA features are: since v2.0.0 full support for the MPI-3.1 specification, support for non-contiguous datatypes, support for direct use of the RDMA capabilities of high performance networks (Cray Gemini/Aries, Infiniband), starting in v2.1.0 will have support for using network atomic operations for MPI_Fetch_and_op and MPI_Compare_and_swap, tested with MPI_THREAD_MULTIPLE.

Comfrey: A Clinical Overview

PubMed Central

Staiger, Christiane

2012-01-01

Comfrey has a centuries-old tradition as a medicinal plant. Today, multiple randomized controlled trials have demonstrated the efficacy and safety of comfrey preparations for the topical treatment of pain, inflammation and swelling of muscles and joints in degenerative arthritis, acute myalgia in the back, sprains, contusions and strains after sports injuries and accidents, also in children aged 3 or 4 and over. This paper provides information on clinical trials and non-interventional studies published on comfrey to date and further literature, substantiating the fact that topical comfrey preparations are a valuable therapy option for the treatment of painful muscle and joint complaints. Copyright © 2012 John Wiley & Sons, Ltd. PMID:22359388

Ethical issues in the translation of social neuroscience: a policy analysis of current guidelines for public dialogue in human research.

PubMed

Zimmerman, Emma; Racine, Eric

2012-01-01

Social neuroscience and its potential implications create an interesting case study for examining human research ethics policies on the topic of public communication of research. We reviewed mainstream national and international human research ethics guidelines and policies on issues of public communication of research. Our analysis relied on five thematic nets to capture the interactions between research and the public: public understanding, knowledge translation, public participation, social outcomes, and dual use. Coverage of these topics is sparse and inconsistent in mainstream policies and guidelines. We identify three options to address these gaps and analyze their strengths and weaknesses.

Exotic Effects at the Charm Threshold and Other Novel Physics Topics at JLab-12 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brodsky, Stanley J.; /SLAC

I briefly survey a number of novel hadron physics topics which can be investigated with the 12 GeV upgrade at J-Lab. The topics include new the formation of exotic heavy quark resonances accessible above the charm threshold, intrinsic charm and strangeness phenomena, the exclusive Sivers effect, hidden-color Fock states of nuclei, local two-photon interactions in deeply virtual Compton scattering, and non-universal antishadowing.

Multi-attribute criteria applied to electric generation energy system analysis LDRD.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuswa, Glenn W.; Tsao, Jeffrey Yeenien; Drennen, Thomas E.

2005-10-01

This report began with a Laboratory-Directed Research and Development (LDRD) project to improve Sandia National Laboratories multidisciplinary capabilities in energy systems analysis. The aim is to understand how various electricity generating options can best serve needs in the United States. The initial product is documented in a series of white papers that span a broad range of topics, including the successes and failures of past modeling studies, sustainability, oil dependence, energy security, and nuclear power. Summaries of these projects are included here. These projects have provided a background and discussion framework for the Energy Systems Analysis LDRD team to carrymore » out an inter-comparison of many of the commonly available electric power sources in present use, comparisons of those options, and efforts needed to realize progress towards those options. A computer aid has been developed to compare various options based on cost and other attributes such as technological, social, and policy constraints. The Energy Systems Analysis team has developed a multi-criteria framework that will allow comparison of energy options with a set of metrics that can be used across all technologies. This report discusses several evaluation techniques and introduces the set of criteria developed for this LDRD.« less

Is case-specificity content-specificity? An analysis of data from extended-matching questions.

PubMed

Dory, Valerie; Gagnon, Robert; Charlin, Bernard

2010-03-01

Case-specificity, i.e., variability of a subject's performance across cases, has been a consistent finding in medical education. It has important implications for assessment validity and reliability. Its root causes remain a matter of discussion. One hypothesis, content-specificity, links variability of performance to variable levels of relevant knowledge. Extended-matching items (EMIs) are an ideal format to test this hypothesis as items are grouped by topic. If differences pertaining to content knowledge are the main cause of case-specificity, variability across topics should be high and variability across items within the same topic low. We used generalisability analysis on results of a written test composed of 159 EMIs sat by two cohorts of general practice trainees at one university. Two hundred and twenty-seven trainees took part. The variance component attributed to subjects was small. Variance attributed to topics was smaller than variance attributed to items. The main source of error was interaction between subjects and items, accounting for two-thirds of error. The generalisability D study revealed that for the same total number of items, increasing the number of topics results in a higher G coefficient than increasing the number of items per topic. Topical knowledge does not seem to explain case-specificity observed in our data. Structure of knowledge and reasoning strategy may be more important, in particular pattern-recognition which EMIs were designed to elicit. The causal explanations of case-specificity may be dependent on test format. Increasing the number of topics with fewer items each would increase reliability but also testing time.

You Say "dientito," I Say "dentito": Navigating Complex Word Formation in Second Language Spanish

ERIC Educational Resources Information Center

Carlson, Matthew T.; Gerfen, Chip

2017-01-01

Native speakers seamlessly marshal morphological resources to create new words, displaying striking consistency even where multiple options are available, as when a stem contains a phonological alternation. This is true even when these options appear to be idiosyncratically applied in existing words. For example, in derived words, the alternation…

An Investigation into the Optimal Number of Distractors in Single-Best Answer Exams

ERIC Educational Resources Information Center

Kilgour, James M.; Tayyaba, Saadia

2016-01-01

In UK medical schools, five-option single-best answer (SBA) questions are the most widely accepted format of summative knowledge assessment. However, writing SBA questions with four effective incorrect options is difficult and time consuming, and consequently, many SBAs contain a high frequency of implausible distractors. Previous research has…

Travel and Tourism Module. An Advanced-Level Option For Distribution and Marketing.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of Occupational Education Curriculum Development.

Intended as an advanced option for distributive education students in the twelfth grade, this travel and tourism module is designed to cover a minimum of ten weeks or a maximum of twenty weeks. Introductory material includes information on employment demands, administrative considerations, course format, teaching suggestions, expected outcomes,…

[Internet search for counseling offers for older adults suffering from visual impairment].

PubMed

Himmelsbach, I; Lipinski, J; Putzke, M

2016-11-01

Visual impairment is a relevant problem of aging. In many cases promising therapeutic options exist but patients are often left with visual deficits, which require a high degree of individualized counseling. This article analyzed which counseling offers can be found by patients and relatives using simple and routine searching via the internet. Analyses were performed using colloquial search terms in the search engine Google in order to find counseling options for elderly people with visual impairments available via the internet. With this strategy 189 offers for counseling were found, which showed very heterogeneous regional differences in distribution. The counseling options found in the internet commonly address topics such as therapeutic interventions or topics on visual aids corresponding to the professions offering rehabilitation most present in the internet, such as ophthalmologists and opticians. Regarding contents addressing psychosocial and help in daily tasks, self-help and support groups offer the most differentiated and broadest spectrum. Support offers for daily living tasks and psychosocial counseling from social providers were more difficult to find with these search terms despite a high presence in the internet. There are a large number of providers of counseling and consulting for older persons with visual impairment. In order to be found more easily by patients and to be recommended more often by ophthalmologists and general practitioners, the presence of providers in the internet must be improved, especially providers of daily living and psychosocial support offers.

Fighting Off Wound Pathogens in Horses with Honeybee Lactic Acid Bacteria.

PubMed

Olofsson, Tobias C; Butler, Éile; Lindholm, Christina; Nilson, Bo; Michanek, Per; Vásquez, Alejandra

2016-10-01

In the global perspective of antibiotic resistance, it is urgent to find potent topical antibiotics for the use in human and animal infection. Healing of equine wounds, particularly in the limbs, is difficult due to hydrostatic factors and exposure to environmental contaminants, which can lead to heavy bio-burden/biofilm formation and sometimes to infection. Therefore, antibiotics are often prescribed. Recent studies have shown that honeybee-specific lactic acid bacteria (LAB), involved in honey production, and inhibit human wound pathogens. The aim of this pilot study was to investigate the effects on the healing of hard-to-heal equine wounds after treatment with these LAB symbionts viable in a heather honey formulation. For this, we included ten horses with wound duration of >1 year, investigated the wound microbiota, and treated wounds with the novel honeybee LAB formulation. We identified the microbiota using MALDI-TOF mass spectrometry and DNA sequencing. In addition, the antimicrobial properties of the honeybee LAB formulation were tested against all wound isolates in vitro. Our results indicate a diverse wound microbiota including fifty-three bacterial species that showed 90 % colonization by at least one species of Staphylococcus. Treatment with the formulation promoted wound healing in all cases already after the first application and the wounds were either completely healed (n = 3) in less than 20 days or healing was in progress. Furthermore, the honeybee LAB formulation inhibited all pathogens when tested in vitro. Consequently, this new treatment option presents as a powerful candidate for the topical treatment of hard-to-heal wounds in horses.

Framework for enhancing clinical practice guidelines through continuous patient engagement.

PubMed

Armstrong, Melissa J; Rueda, Juan-David; Gronseth, Gary S; Mullins, C Daniel

2017-02-01

Patient engagement in clinical practice guideline (CPG) development is recommended by multiple institutions and instruments measuring guideline quality. Approaches to engaging patients, however, vary between oversight organizations, quality tools and guideline developers. We propose a ten-step framework outlining steps and options for patient engagement in guideline development with the goal of highlighting steps for patient engagement and methods by which this can be achieved. This framework provides a model for continuous patient engagement in CPGs by outlining ten steps of guideline development occurring at the levels of the developer/committee and the individual guideline project. At the developer level, patients can assist in topic nomination (step 1), topic prioritization (step 2) and guideline development group selection (step 3). Within specific guideline projects, patients' opinions may be incorporated when framing the question (step 4), creating an analytic framework and research plan (step 5), conducting the systematic review and conclusion formation (step 6), development of recommendations (step 7) and dissemination and implementation (step 8). At the end of process, patients can again be engaged at the developer level by helping determine when guidelines need updating (step 9) and evaluating the developer's approach to patient engagement (step 10). Patient engagement at each CPG development step has different purposes, mechanisms, advantages and disadvantages, and implications for resource utilization. This framework can serve as a resource for guideline developers desiring to increase patient engagement and reference for researchers investigating engagement methodology at different steps of the CPG lifecycle. © 2016 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

KAM (Knowledge Acquisition Module): A tool to simplify the knowledge acquisition process

NASA Technical Reports Server (NTRS)

Gettig, Gary A.

1988-01-01

Analysts, knowledge engineers and information specialists are faced with increasing volumes of time-sensitive data in text form, either as free text or highly structured text records. Rapid access to the relevant data in these sources is essential. However, due to the volume and organization of the contents, and limitations of human memory and association, frequently: (1) important information is not located in time; (2) reams of irrelevant data are searched; and (3) interesting or critical associations are missed due to physical or temporal gaps involved in working with large files. The Knowledge Acquisition Module (KAM) is a microcomputer-based expert system designed to assist knowledge engineers, analysts, and other specialists in extracting useful knowledge from large volumes of digitized text and text-based files. KAM formulates non-explicit, ambiguous, or vague relations, rules, and facts into a manageable and consistent formal code. A library of system rules or heuristics is maintained to control the extraction of rules, relations, assertions, and other patterns from the text. These heuristics can be added, deleted or customized by the user. The user can further control the extraction process with optional topic specifications. This allows the user to cluster extracts based on specific topics. Because KAM formalizes diverse knowledge, it can be used by a variety of expert systems and automated reasoning applications. KAM can also perform important roles in computer-assisted training and skill development. Current research efforts include the applicability of neural networks to aid in the extraction process and the conversion of these extracts into standard formats.

Constellation Overview: Ares V Solar System Science Workshop

NASA Technical Reports Server (NTRS)

Horack, John M.

2008-01-01

Presentation topics include: what is NASA's mission, why the Moon next, options for Moon landings, NASA's exploration roadmap, building on a foundation of proven technologies - launch vehicle comparisons, Ares nationwide team, Ares I elements, vehicle integration accomplishments, Aires I-X test flight, Ares I-X accomplishments, Orion crew exploration vehicle, Altair lunar lander, and Ares V elements.

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT VII, AUTOMATIC TRANSMISSIONS--ALLISON, TORQUMATIC SERIES 5960 AND 6060 (PART I).

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF SPECIFIC MODELS OF AUTOMATIC TRANSMISSIONS USED ON DIESEL POWERED VEHICLES. TOPICS ARE (1) GENERAL SPECIFICATION DATA, (2) OPTIONS FOR VARIOUS APPLICATIONS, (3) ROAD TEST INSTRUCTIONS, (4) IDENTIFICATION AND SPECIFICATION DATA, (5) ALLISON…

Design Your Future: College & Career Preparation Guide, 2014-2015

ERIC Educational Resources Information Center

North Dakota University System, 2014

2014-01-01

This publication was created to help eighth-grade students make a successful transition to high school and begin looking at college and career options. Topics covered in the booklet include: (1) Making the transition to high school; (2) Meeting state academic standards; (3) Taking the courses needed to complete high school and to meet college…

45 CFR Appendix B to Part 1356 - NYTD Youth Outcome Survey

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false NYTD Youth Outcome Survey B Appendix B to Part... APPLICABLE TO TITLE IV-E Pt. 1356, App. B Appendix B to Part 1356—NYTD Youth Outcome Survey Topic/element # Question to youth and response options Definition INFORMATION TO COLLECT FROM ALL YOUTH SURVEYED FOR...

45 CFR Appendix B to Part 1356 - NYTD Youth Outcome Survey

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false NYTD Youth Outcome Survey B Appendix B to Part... APPLICABLE TO TITLE IV-E Pt. 1356, App. B Appendix B to Part 1356—NYTD Youth Outcome Survey Topic/element # Question to youth and response options Definition INFORMATION TO COLLECT FROM ALL YOUTH SURVEYED FOR...

Commentary to "Multiple Grammars and Second Language Representation," by Luiz Amaral and Tom Roeper

ERIC Educational Resources Information Center

Pérez-Leroux, Ana T.

2014-01-01

In this commentary, the author defends the Multiple Grammars (MG) theory proposed by Luiz Amaral and Tom Roepe (A&R) in the present issue. Topics discussed include second language acquisition, the concept of developmental optionality, and the idea that structural decisions involve the lexical dimension. The author states that A&R's…

Graduation Policies for Students with Disabilities Who Participate in States' General Assessments. Synthesis Report 98

ERIC Educational Resources Information Center

Thurlow, Martha L.; Albus, Debra A.; Lazarus, Sheryl S.

2015-01-01

Graduation requirements and diploma options for students with disabilities who participate in the general assessment has been a topic of interest for many years. The recent push for all students, including those with disabilities, to leave school ready for college and career has heightened the importance of understanding what states are requiring…

Issues in Evaluating Importance Weighting in Quality of Life Measures

ERIC Educational Resources Information Center

Hsieh, Chang-ming

2013-01-01

For most empirical research investigating the topic of importance weighting in quality of life (QoL) measures, the prevailing approach has been to use (1) a limited choice of global QoL measures as criterion variables (often a single one) to determine the performance of importance weighting, (2) a limited option of weighting methods to develop…

Creating Regional Futures: A Scenario-Based Inter- and Transdisciplinary Case Study as a Model for Applied Student-Centred Learning in Geography

ERIC Educational Resources Information Center

Fromhold-Eisebith, Martina; Freyer, Bernhard; Mose, Ingo; Muhar, Andreas; Vilsmaier, Ulli

2009-01-01

Human geography students face changing qualification requirements due to a shift towards new topics, educational tasks and professional options regarding issues of spatial development. This "practical turn" raises the importance of inter- and transdisciplinary work, management and capability building skills, with case study projects and…

Probing the Natural World, Level III, Student Guide: Investigating Variation. Intermediate Science Curriculum Study.

ERIC Educational Resources Information Center

Bonar, John R., Ed.; Hathway, James A., Ed.

This is the student's text of one unit of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on diversity in human populations, measurement, and data collection. Numerous activities are given and optional excursions encourage students to pursue a topic in greater depth. Data tables within the…

Omnivorous Representation Might Lead to Indigestion: Commentary on Amaral and Roeper

ERIC Educational Resources Information Center

Slabakova, Roumyana

2014-01-01

This article offers commentary that the Multiple Grammar (MG) language acquisition theory proposed by Luiz Amaral and Tom Roeper (A&R) in the present issue lacks elaboration of the psychological mechanisms at work in second language acquisition. Topics discussed include optionality in a speaker's grammar and the rules of verb position in…

Research-Informed Policy Options for Infant and Toddler Early Care and Education: Research-to-Policy Resources

ERIC Educational Resources Information Center

Stephens, Samuel A.

2016-01-01

This Research-to-Policy Resource List compiles research-based policy documents published in 2010 and later on the following topics: Early learning guidelines for infants and toddlers; Program standards for settings serving infants and toddlers; Core competencies and credentials for caregivers of infants and toddlers; Use of infant/toddler…

Assessing Advanced High School and Undergraduate Students' Thinking Skills: The Chemistry--From the Nanoscale to Microelectronics Module

ERIC Educational Resources Information Center

Dori, Yehudit Judy; Dangur, Vered; Avargil, Shirly; Peskin, Uri

2014-01-01

Chemistry students in Israel have two options for studying chemistry: basic or honors (advanced placement). For instruction in high school honors chemistry courses, we developed a module focusing on abstract topics in quantum mechanics: Chemistry--From the Nanoscale to Microelectronics. The module adopts a visual-conceptual approach, which…

School Consolidation: Is Bigger Better? Part II. Options in Education, Program #90.

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC. Inst. for Educational Leadership.

This publication is the complete transcript of a weekly radio program devoted to contemporary issues in American education. This particular program is the second of two that focus on the topic of school consolidation. In separate segments of the program, Wendy Blair and John Merrow of National Public Radio discuss declining school enrollment and…

Options in Education Transcript: Program No. 138: "Beyond Bakke."

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC. Inst. for Educational Leadership.

In this transcript of a radio program about the Bakke case, a news team covers the following topics: (1) Vernon Jordan's admonitions to use restraint in assessing the implications of Bakke; (2) blacks' suspicions about affirmative action; (3) Robert McKay's thoughts on the meaning of Bakke; (4) McGeorge Bundy's thoughts on the Harvard Admissions…

Space station needs, attributes and architectural options. Volume 3, attachment 1, task 1: Mission requirements

NASA Technical Reports Server (NTRS)

1983-01-01

The development and systems architectural requirements of the space station program are described. The system design is determined by user requirements. Investigated topics include physical and life science experiments, commercial utilization, U.S. national security, and remote space operations. The economic impact of the space station program is analyzed.

Climatizing the Home Minicourse, Career Oriented Pre-Technical Physics. Preliminary Edition.

ERIC Educational Resources Information Center

Bullock, Bob; And Others

This minicourse was prepared for use with secondary physics students in the Dallas Independent School District and is one option in a physics program which provides for the selection of topics on the basis of student career needs and interests. This minicourse was aimed at providing students with a knowledge of the physics factors that determine…

Polarized e-bunch acceleration at Cornell RCS: Tentative tracking simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meot, F.; Ptitsyn, V.; Ranjbar, V.

2017-10-19

An option as an injector into eRHIC electron storage ring is a rapid-cyclic synchrotron (RCS). Rapid acceleration of polarized electron bunches has never been done, Cornell synchrotron might lend itself to dedicated tests, which is to be first explored based on numerical investigations. This paper is a very preliminary introduction to the topic.

General Military Training: Standardization and Reduction Options

DTIC Science & Technology

2012-01-01

pregnancy prevention (navy) n Y n Y n Y III SGLI (Marine Corps) n n n Y n Y III Table A.1—Continued Our Assessment of Topics That Meet the Approved...sensitive issues promotes trust and unit esprit de corps. The Army chooses to uti - lize time for CMT as an opportunity for a unit leader to mentor

Automobile Ignition System Minicourse, Career Oriented Pre-Technical Physics. Preliminary Edition.

ERIC Educational Resources Information Center

Bullock, Bob; And Others

This minicourse was prepared for use with secondary physics students in the Dallas Independent School District and is one option in a physics program which provides for the selection of topics on the basis of student career needs and interests. This minicourse was aimed at providing the student with a basic understanding of the construction and…

Topical 5% 5-fluorouracil in the treatment of multifocal basal cell carcinoma of the face: A novel chemotherapeutic approach.

PubMed

Naik, Mayuresh P; Mehta, Anuj; Abrol, Sangeeta; Kumar, Sandeep; Gupta, Vishnu S

2016-12-01

To determine the safety and efficacy of topical 5-fluorouracil (5-FU) 5% ointment in treatment of non-syndromic multifocal basal cell carcinoma. A 55-year-old male patient, with 8 hours of daily sun exposure, having histologically proven and radiologically non-syndromic, multifocal basal cell carcinoma with involvement of 6 sites on the face, was treated with topical 5-FU 5% ointment twice daily over all sites except the site involving lid margin to prevent corneal toxicity. Left lid lesion underwent wide surgical excision with 5-mm clear margins and reconstruction with nasal septal mucoperichondrium and local skin mobilization. Pharmacologic effects first appeared at 4 weeks and by 8 weeks, the lesions had scabbed and had fallen off with no induration but residual mild perilesional erythema. Patient had post-op histopathological clear margins and recovered uneventfully. No recurrence in 6 months. A topical 5-FU 5% ointment represents a paradigm shift in the treatment of BCC from invasive and disfiguring options (surgery and chemoradiotherapy) to cheap, convenient, effective, non-invasive, non-disfiguring topical chemotherapy. Topical 5% 5-FU is a safe and effective modality of treatment of superficial spreading multifocal basal carcinoma, especially lesions larger than 10 mm, where margins cannot be identified clearly and recurrent lesions.

Eczema therapeutics in children: what do the clinical trials say?

PubMed

Leung, Theresa N H; Hon, K L

2015-06-01

Eczema or atopic dermatitis is a common childhood atopic disease associated with chronicity and impaired quality of life. As there is no cure for the disease, treatment relies on topical and systemic anti-allergic or immunomodulating therapies. Topical corticosteroid, macrolide immunosuppressants, and oral immunomodulating drugs for recalcitrant disease have been the mainstay of therapy. Management of atopic dermatitis must consider the individual symptomatic variability of the disease. Basic therapy is focused on patient/family education, hydrating topical treatment, and avoidance of specific and non-specific provocative factors. Anti-inflammatory treatment based on topical glucocorticosteroids and topical calcineurin inhibitors is used for exacerbation management and more recently in selective cases for proactive therapy. Systemic immunosuppressive treatment is an option for severe refractory cases. Microbial colonisation and superinfection may induce disease exacerbation and justify additional antimicrobial treatment. Adjuvant therapy includes ultraviolet (UV) irradiation preferably with UVA1 or narrowband UVB. Dietary recommendations should be specific and given only when food allergy is confirmed. Allergen-specific immunotherapy against aeroallergens may be useful in selected cases. Parallel use of traditional and proprietary topical and herbal medicine has also been popular in China and many cities in Asia. Complementary and alternative medicine may have a place but evidence-based data are lacking.

Topics in Hawaii's History: Resources and Lesson Plans for Secondary School Teachers.

ERIC Educational Resources Information Center

Odo, Franklin, Ed.; Kawamoto, Kevin, Ed.; McGregor, Davianna, Ed.

Twenty-nine teachers participated in a 4-week National Endowment for the Humanities institute which covered topics from pre-contact Hawaiian population estimates to formation of plantation workforces to contemporary sovereignty issues. The lessons the participants developed are divided into nine sections. Section 1, "Geography," contains…

Coal Activities for Secondary Students.

ERIC Educational Resources Information Center

American Coal Foundation, Washington, DC.

This collection of lesson plans designed for teachers of 4th- through 12th-grade students utilizes an assortment of teaching strategies for topics related to coal and the coal industry. Activities cover the following topics: coal formation; coal identification; "the geologist's dilemma" (a supply and demand activity); geologic time and…

Interactive Multimedia Module with Pedagogical Agents: Formative Evaluation

ERIC Educational Resources Information Center

Lee, Tien Tien; Osman, Kamisah

2012-01-01

Electrochemistry is found to be a difficult topic to learn due to its abstract concepts that involve three representation levels. Research showed that animation and simulation using Information and Communication Technology can help students to visualize and thus enhance students' understanding in learning abstract chemistry topics. As a result, an…

Secondary Social Studies: Alaska Curriculum Guide. Second Edition.

ERIC Educational Resources Information Center

Alaska State Dept. of Education, Juneau. Office of Curriculum Services.

A secondary social studies model curriculum guide for Alaska is presented. The body of the guide lists topics/concepts, learning outcomes/objectives, and sample learning activities in a 3 column format. The first column, topics/concepts, describes the content area, defining the subject broadly and listing subconcepts or associated vocabulary. The…

Energy Management Lesson Plans for Vocational Agriculture Instructors.

ERIC Educational Resources Information Center

Hedges, Lowell E., Ed.; Miller, Larry E., Ed.

This notebook provides vocational agricultural teachers with 10 detailed lesson plans on the major topic of energy management in agriculture. The lesson plans present information about energy and the need to manage it wisely, using a problem-solving approach. Each lesson plan follows this format: lesson topic, lesson performance objectives,…

Assessment of Cognitive Requirements of Instructional Materials

ERIC Educational Resources Information Center

Hartford, Fred; Good, Ron

1976-01-01

Evaluates the CHEM study topics of kinetic theory of gases, phase changes, chemical bonds, and equilibrium as to the level of cognitive development required for an understanding of each subject. Advocates an assignment of topics within the range of a student's cognitive ability in an individual study format of instruction. (CP)

Soil Formation and Distribution in Missouri. Instructional Unit. Conservation Education Series.

ERIC Educational Resources Information Center

Castillon, David A.

This unit is designed to help vocational agriculture teachers incorporate information on soil formation and the soils geography of Missouri into their curriculum. The unit consists of: (1) a topic outline; (2) general unit objectives; (3) discussions of processes and factors of soil formation, the soils geography of Missouri, and some soil…

Diagnosis and Management of Onychomycosis: Perspectives from a Joint Podiatry-Dermatology Roundtable.

PubMed

Markinson, Bryan C; Vlahovic, Tracey C; Joseph, Warren S; Scher, Richard K; Tosti, Antonella; Plasencia, Jesse; Pariser, David M

2015-09-25

Onychomycosis is a fungal infection, and, as such, one of the goals of treatment should be eradication of the infective agent. Despite this, in contrast to dermatologists, many podiatric physicians do not include antifungals in their onychomycosis treatment plans. Before initiating treatment, confirmation of mycologic status via laboratory testing (eg, microscopy with potassium hydroxide preparation, histopathology with periodic acid-Schiff staining, fungal culture, and polymerase chain reaction) is important; however, more podiatric physicians rely solely on clinical signs than do dermatologists. These dissimilarities may be due, in part, to differences between specialties in training, reimbursement patterns, or practice orientation, and to explore these differences further, a joint podiatric medicine-dermatology roundtable was convened. In addition, treatment options have been limited owing to safety concerns with available oral antifungals and relatively low efficacy with previously available topical treatments. Recently approved topical treatments-efinaconzole and tavaborole-offer additional options for patients with mild-to-moderate disease. Debridement alone has no effect on mycologic status, and it is recommended that it be used in combination with an oral or topical antifungal. There is little to no clinical evidence to support the use of lasers or over-the-counter treatments for onychomycosis. After a patient has achieved cure (absence of clinical signs or absence of fungus with minimal clinical signs), lifestyle and hygiene measures, prophylactic/maintenance treatment, and proactive treatment for tinea pedis, including in family members, may help maintain this status.

Diagnosis and Management of Onychomycosis Perspectives from a Joint Podiatric Medicine-Dermatology Roundtable.

PubMed

Vlahovic, Tracey C; Joseph, Warren S; Scher, Richard K; Tosti, Antonella; Plasencia, Jesse; Pariser, David M; Markinson, Bryan C

2016-03-01

Onychomycosis is a fungal infection, and, as such, one of the goals of treatment should be eradication of the infective agent. Despite this, in contrast to dermatologists, many podiatric physicians do not include antifungals in their onychomycosis treatment plans. Before initiating treatment, confirmation of mycologic status via laboratory testing (eg, microscopy with potassium hydroxide preparation, histopathology with periodic acid-Schiff staining, fungal culture, and polymerase chain reaction) is important; however, more podiatric physicians rely solely on clinical signs than do dermatologists. These dissimilarities may be due, in part, to differences between specialties in training, reimbursement patterns, or practice orientation, and to explore these differences further, a joint podiatric medicine-dermatology roundtable was convened. In addition, treatment options have been limited owing to safety concerns with available oral antifungals and relatively low efficacy with previously available topical treatments. Recently approved topical treatments-efinaconzole and tavaborole-offer additional options for patients with mild-to-moderate disease. Debridement alone has no effect on mycologic status, and it is recommended that it be used in combination with an oral or topical antifungal. There is little to no clinical evidence to support the use of lasers or over-the-counter treatments for onychomycosis. After a patient has achieved cure (absence of clinical signs or absence of fungus with minimal clinical signs), lifestyle and hygiene measures, prophylactic/maintenance treatment, and proactive treatment for tinea pedis, including in family members, may help maintain this status.

Topical clobetasol in conjunction with topical tretinoin is effective in preventing scar formation after superficial partial-thickness burn ulcers of the skin: A retrospective study.

PubMed

Taheri, Arash; Moradi Tuchayi, Sara; Alinia, Hossein; Orscheln, Courtney S; Mansoori, Parisa; Feldman, Steven R

2015-01-01

Deep erythema and inflammation after re-epithelialization of superficial wounds is a sign of scar formation. Corticosteroids may prevent scarring by suppression of inflammation and fibroblast activity. Tretinoin may increase the efficacy of corticosteroids in this setting. To evaluate the efficacy of corticosteroids plus tretinoin for prevention of scars after superficial wounds. In a retrospective study of patients with superficial partial thickness thermal skin burn, we compared the patients who received clobetasol plus tretinoin after re-epithelialization with patients who did not receive any medication. Clobetasol propionate 0.05% ointment was used twice daily with overnight occlusive dressing in conjunction with twice weekly topical tretinoin 0.05% cream. Among 43 patients who had light pink or no erythema after re-epithelialization and consequently did not receive clobetasol + tretinoin, no scar was developed. Among patients who had deep erythema after re-epithelialization, rate of scar formation was significantly higher in 14 patients who did not receive clobetasol + tretinoin than in 21 patients who received clobetasol + tretinoin (64% and 19%, respectively; p = 0.01). Clobetasol + tretinoin can significantly decrease the incidence of scar formation in patients with inflammation after re-epithelialization of superficial wounds.

The Development of the Planet Formation Concept Inventory: A Preliminary Analysis of Version 1

NASA Astrophysics Data System (ADS)

Simon, Molly; Impey, Chris David; Buxner, Sanlyn

2018-01-01

The topic of planet formation is poorly represented in the educational literature, especially at the college level. As recently as 2014, when developing the Test of Astronomy Standards (TOAST), Slater (2014) noted that for two topics (formation of the Solar System and cosmology), “high quality test items that reflect our current understanding of students’ conceptions were not available [in the literature]” (Slater,2014, p. 8). Furthermore, nearly half of ASTR 101 enrollments are at 2 year/community colleges where both instructors and students have little access to current research and models of planet formation. In response, we administered six student replied response (SSR) short answer questions on the topic of planet formation to n = 1,050 students enrolled in introductory astronomy and planetary science courses at The University of Arizona in the Fall 2016 and Spring 2017 semesters. After analyzing and coding the data from the SSR questions, we developed a preliminary version of the Planet Formation Concept Inventory (PFCI). The PFCI is a multiple-choice instrument with 20 planet formation-related questions, and 4 demographic-related questions. We administered version 1 of the PFCI to six introductory astronomy and planetary science courses (n ~ 700 students) during the Fall 2017 semester. We provided students with 7-8 multiple-choice with explanation of reasoning (MCER) questions from the PFCI. Students selected an answer (similar to a traditional multiple-choice test), and then briefly explained why they chose the answer they did. We also conducted interviews with ~15 students to receive feedback on the quality of the questions and clarity of the instrument. We will present an analysis of the MCER responses and student interviews, and discuss any modifications that will be made to the instrument as a result.

Topical anti-infective sinonasal irrigations: update and literature review.

PubMed

Lee, Jivianne T; Chiu, Alexander G

2014-01-01

Sinonasal anti-infective irrigations have emerged as a promising therapeutic modality in the comprehensive management of chronic rhinosinusitis (CRS), particularly in the context of recalcitrant disease. The purpose of this article was to delineate the current spectrum of topical anti-infective therapies available and evaluate their role in the treatment of CRS. A systematic literature review was performed on all studies investigating the use of topical antimicrobial solutions in the medical therapy of CRS. Anti-infective irrigations were stratified into topical antibacterial, antifungal, and additive preparations according to their composition and respective microbicidal properties. The use of topical antibiotic irrigations has been supported by low-level studies in the treatment of refractory CRS, with optimal results achieved in patients who have undergone prior functional endoscopic sinus surgery and received culture-directed therapy. Multiple evidence-based reviews have not established any clinical benefit with the administration of topical antifungals, and their use is not currently recommended in the management of routine CRS. Topical additives including surfactants may be beneficial as adjunctive treatment for recalcitrant CRS, but additional research is needed to investigate their efficacy in comparison with other agents and establish safety profiles. Topical anti-infective solutions are not recommended as first-line therapy for routine CRS but may be considered as a potential option for patients with refractory CRS who have failed traditional medical and surgical intervention. Additional research is necessary to determine which patient populations would derive the most benefit from each respective irrigation regimen and identify potential toxicities associated with prolonged use.

Rasch analyses of the Activities-specific Balance Confidence Scale with individuals 50 years and older with lower limb amputations

PubMed Central

Sakakibara, Brodie M.; Miller, William C.; Backman, Catherine L.

2012-01-01

Objective To explore shortened response formats for use with the Activities-specific Balance Confidence scale and then: 1) evaluate the unidimensionality of the scale; 2) evaluate the item difficulty; 3) evaluate the scale for redundancy and content gaps; and 4) evaluate the item standard error of measurement (SEM) and internal consistency reliability among aging individuals (≥50 years) with a lower-limb amputation living in the community. Design Secondary analysis of cross-sectional survey and chart review data. Setting Out-patient amputee clinics, Ontario, Canada. Participants Four hundred forty eight community living adults, at least 50 years old (mean = 68 years), who have used a prosthesis for at least 6 months for a major unilateral lower limb amputation. Three hundred twenty five (72.5%) were men. Intervention N/a Main Outcome Measure(s) Activities-specific Balance Confidence Scale. Results A 5-option response format outperformed 4- and 6-option formats. Factor analyses confirmed a unidimensional scale. The distance between response options is not the same for all items on the scale, evident by the Partial Credit Model (PCM) having a better fit to the data than the Rating Scale Model. Two items, however, did not fit the PCM within statistical reason. Revising the wording of the two items may resolve the misfit, and improve the construct validity and lower the SEM. Overall, the difficulty of the scale’s items is appropriate for use with aging individuals with lower-limb amputation, and is most reliable (Cronbach ∝ = 0.94) for use with individuals with moderately low balance confidence levels. Conclusions The ABC-scale with a simplified 5-option response format is a valid and reliable measure of balance confidence for use with individuals aging with a lower limb amputation. PMID:21704978

Ground Operations Aerospace Language (GOAL). Volume 4: Interpretive code translator

NASA Technical Reports Server (NTRS)

1973-01-01

This specification identifies and describes the principal functions and elements of the Interpretive Code Translator which has been developed for use with the GOAL Compiler. This translator enables the user to convert a compliled GOAL program to a highly general binary format which is designed to enable interpretive execution. The translator program provides user controls which are designed to enable the selection of various output types and formats. These controls provide a means for accommodating many of the implementation options which are discussed in the Interpretive Code Guideline document. The technical design approach is given. The relationship between the translator and the GOAL compiler is explained and the principal functions performed by the Translator are described. Specific constraints regarding the use of the Translator are discussed. The control options are described. These options enable the user to select outputs to be generated by the translator and to control vrious aspects of the translation processing.

[Transplant cross-over, an attractive option].

PubMed

Maddalena, Emanuela

2013-01-01

Kidney transplant from living donors is an excellent option for patients with end- stage renal disease: around the world approximately 10-20% of patients on waiting lists have intended living donors incompatible by blood type or for the presence of donor-specific antibodies. Current strategies to overcome these barriers are desensitization protocols and the recent option of the kidney exchange programs. In this work we describe the types of donor exchange programs, from the two-way Kidney Paired Donation, where two incompatible donor-recipient couples exchange donors, to complex chains of transplants where the altruistic donation of a kidney (Living Non-direct Donor, or non-specific donation) is associated to a Kidney Paired Exchange Program (Domino Kidney Paired Donation, NEAD chains). The thesis also discusses some related ethical topics that have become international matters of debate, as well as some important cultural and social arguments for and against the application of kidney exchanges in Italy.

Update on the management of rosacea

PubMed Central

Weinkle, Allison P; Doktor, Vladyslava; Emer, Jason

2015-01-01

Refining diagnostic criteria has identified key characteristics differentiating rosacea, a chronic skin disorder, from other common cutaneous inflammatory conditions. The current classification system developed by the National Rosacea Society Expert Committee consists of erythematotelangiectatic, papulopustular, phymatous, and ocular subtypes. Each subtype stands as a unique entity among a spectrum, with characteristic symptoms and physical findings, along with an intricate pathophysiology. The main treatment modalities for rosacea include topical, systemic, laser, and light therapies. Topical brimonidine tartrate gel and calcineurin inhibitors are at the forefront of topical therapies, alone or in combination with traditional therapies such as topical metronidazole or azelaic acid and oral tetracyclines or isotretinoin. Vascular laser and intense pulsed light therapies are beneficial for the erythema and telangiectasia, as well as the symptoms (itching, burning, pain, stinging, swelling) of rosacea. Injectable botulinum toxin, topical ivermectin, and microsecond long-pulsed neodymium-yttrium aluminum garnet laser are emerging therapies that may prove to be extremely beneficial in the future. Once a debilitating disorder, rosacea has become a well known and manageable entity in the setting of numerous emerging therapeutic options. Herein, we describe the treatments currently available and give our opinions regarding emerging and combination therapies. PMID:25897253

Phosphodiesterase 4 inhibitors.

PubMed

Zebda, Rema; Paller, Amy S

2018-03-01

Historically, drugs available for treating atopic dermatitis (AD) have been limited to topical corticosteroids and topical calcineurin inhibitors, with systemic immunosuppressants and phototherapy reserved for severe AD. Despite their efficacy and infrequent adverse events, phobia about the use of topical steroids and calcineurin inhibitors has limited their use. More targeted options with fewer systemic and cutaneous side effects are needed for treating AD. Phosphodiesterase 4 (PDE4) is involved in the regulation of proinflammatory cytokines via the degradation of cyclic adenosine monophosphate. PDE4 activity is increased in the inflammatory cells of patients with AD, leading to increased production of proinflammatory cytokines and chemokines. Targeting PDE4 reduces the production of these proinflammatory mediators in AD. Both topical and oral PDE4 inhibitors have a favorable safety profile. Crisaborole 2% ointment, a topical PDE4, is now US Food and Drug Administration-approved for children older than 2 years and adults in the treatment of AD. Crisaborole 2% ointment shows early and sustained improvement in disease severity and pruritus and other AD symptoms, with burning and/or stinging upon application as the only related adverse event. Other PDE4 inhibitors are currently in trials with promising efficacy and safety. Copyright © 2017. Published by Elsevier Inc.

Dapsone for topical use in extemporaneous preparations.

PubMed

Wohlrab, Johannes; Michael, Julia

2018-01-01

The sulfone dapsone has an established role in systemic therapy. Its pharmacological and toxicological properties are well known. Topically, dapsone is used in a gel formulation for the treatment of acne vulgaris. In addition, there have been individual case reports on the efficacy of topical dapsone preparations in the treatment of various neutrophilic dermatoses. To date, no finished medicinal product for topical use has been available in Germany. Against this background, we set out to develop extemporaneous preparations containing dapsone (5 %) that meet the quality requirements of the European Pharmacopoeia as well as the manufacturing requirements of the German Ordinance on the Operation of Pharmacies (ApBetrO). These formulations included the incorporation of dapsone in a hydrophobic cream base ("hydrophobe Basiscreme DAC") as well as in methylprednisolone aceponate 0.1 % ointment (alternatively, in the latter's cream base without active ingredient). Tests aimed at investigating the physical, chemical, and microbiological stability of these formulations showed them to meet the aforementioned quality requirements. The extemporaneous formulations presented herein broaden the therapeutic options for topical treatment, in particular for patients with chronic inflammatory dermatoses associated with a neutrophilic pathogenesis. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Topical Ginger Treatment With a Compress or Patch for Osteoarthritis Symptoms.

PubMed

Therkleson, Tessa

2014-09-01

This article is a report of a study evaluating changes in health status before and after topical ginger treatment for adults with moderate to severe osteoarthritis. In 2011, 20 adults with chronic osteoarthritis were randomly assigned to one of two groups for 7 consecutive days of topical ginger treatment by trained nurses: Group 1 received a manually prepared ginger compress and Group 2 a standardized ginger patch. Participants had the option to continue self-treatment using the ginger patch for a further 24 weeks. A brief arthritis health questionnaire was completed weekly for 3 weeks and 4 weekly for 24 weeks. The mean scores for Group 1 and Group 2 show a notable decline following 1-week topical ginger treatment; scores in pain, fatigue, global effect, and functional status reduced by 48%, 49%, 40%, and 31%, respectively, whereas health satisfaction improved from 80% dissatisfied to 70% satisfied. Scores for all participants in all five domains progressively reduced over the following 24 weeks of self-treatment. Topical ginger treatment has the potential to relieve symptoms, improve the overall health, and increase independence of people with chronic osteoarthritis. © The Author(s) 2013.

Tarjetas v.1.2015.7.23

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burchard, Ross L.; Pierson, Kathleen P.; Trumbo, Derek

Tarjetas is used to generate requirements from source documents. These source documents are in a hierarchical XML format that have been produced from PDF documents processed through the “Reframe” software package. The software includes the ability to create Topics and associate text Snippets with those topics. Requirements are then generated and text Snippets with their associated Topics are referenced to the requirement. The software maintains traceability from the requirement ultimately to the source document that produced the snippet

Effects of topical anesthetics on Pullalaria pullulans and Debaryomyces hansenii.

PubMed

Merdinger, E; Guthmann, W S; Mangine, F W

1969-09-01

The inhibitory effects of three topical anesthetics of various concentrations on the growth of Pullularia pullulans, Debaryomyces hansenii, and on pigment production by P. pullulans were investigated. The topical anesthetics were benoxinate hydrochloride, proparacaine hydrochloride, and tetracaine hydrochloride. In decreasing order, the inhibiting effects of the drugs on growth were benoxinate, tetracaine, and proparacaine for P. pullulans, and tetracaine, benoxinate, and proparacaine for D. hansenii. The pigment formation in P. pullulans was inhibited by the three drugs.

Clinical trial data in support of changing guidelines in osteoarthritis treatment

PubMed Central

Balmaceda, Casilda M

2014-01-01

Goals for the management of osteoarthritis (OA) emphasize pain relief, reduction of inflammation, and improvement in functioning. Among pharmacological pain management interventions, nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently recommended as the most effective treatment option for OA. However, the use of traditional oral NSAIDs is associated with risk of serious adverse events involving the gastrointestinal, cardiovascular, and renal systems. Topical NSAIDs are an alternative with well-established tolerability and efficacy in the treatment of OA of the knee or hand. While the management of OA pain is evolving toward the more widespread use of topical NSAIDs, some OA management guidelines have yet to incorporate these agents in their recommendations. This review examines the efficacy and tolerability of topical NSAIDs, their current placement in OA management guidelines, and their potential role in enabling pain specialists to provide individualized care for their patients with OA. PMID:24748817

Continuing education needs assessment of pharmacists in the United Arab Emirates.

PubMed

Hasan, Sanah

2009-12-01

The main objective of this study was to offer an insight on the issue of continuing education (CE) in the UAE and to determine the type and format of CE pharmacists in this country prefer to attend and consider most effective. A multi-theme survey was developed to find the reasons pharmacists choose to attend different CE programs, the survey assessed continuing education needs and preferences of pharmacists. Survey items included the types of formats and topics pharmacists prefer to attend and think are most useful to enhance their knowledge and skill. Finally the survey explored some barriers pharmacists conceive as such to attending effective CE. One hundred thirty-two surveys were included in this study, the vast majority of the participants were bachelor's degree holders who were 40 years and younger. The participant's main types of employment were marketing and hospital practice. Pharmacists' preferences as for the format and topic type for programs they would like to attend were identified and compared to other practice settings. Barriers to attending effective CE programs were also elicited. Interactive workshops were recognized as the most favorable format for CE in this study, computer and internet-based formats were also ranked highly by participants followed by live-in person and printed material-based programs. Topics covering innovations in pharmacy practice and disease management were at the top of priorities for pharmacists who would also like to see more certificate programs be offered to them.

Taiwan Ascii and Idl_save Data Archives (AIDA) for THEMIS

NASA Astrophysics Data System (ADS)

Lee, B.; Hsieh, W.; Shue, J.; Angelopoulos, V.; Glassmeier, K. H.; McFadden, J. P.; Larson, D.

2008-12-01

THEMIS (Time History of Events and their Macroscopic Interactions during Substorms) is a satellite mission that aims to determine where and how substorms are triggered. The space research team in Taiwan has been involved in data promotion and scientific research. Taiwan Ascii and Idl_save Data Archives (AIDA) for THEMIS is the main work of the data promotion. Taiwan AIDA is developed for those who are not familiar with the Interactive Data Language (IDL) data analysis and visualization software, and those who have some basic IDL concepts and techniques and want more flexibilities in reading and plotting the THEMIS data. Two kinds of data format are stored in Taiwan AIDA: one is ASCII format for most users and the other is IDL SAVE format for IDL users. The public can download THEMIS data in either format through the Taiwan AIDA web site, http://themis.ss.ncu.edu.tw/e_data_download.php. Taiwan AIDA provides (1) plasma data including number density, average temperature, and velocity of ions and electrons, (2) magnetic field data, and (3) state information including the position and velocity of five THEMIS probes. On the Taiwan AIDA web site there are two data-downloading options. The public can download a large amount of data for a particular instrument in the FTP equivalent option; the public can also download all the data for a particular date in the Data Search option.

The impact of two multiple-choice question formats on the problem-solving strategies used by novices and experts.

PubMed

Coderre, Sylvain P; Harasym, Peter; Mandin, Henry; Fick, Gordon

2004-11-05

Pencil-and-paper examination formats, and specifically the standard, five-option multiple-choice question, have often been questioned as a means for assessing higher-order clinical reasoning or problem solving. This study firstly investigated whether two paper formats with differing number of alternatives (standard five-option and extended-matching questions) can test problem-solving abilities. Secondly, the impact of the alternatives number on psychometrics and problem-solving strategies was examined. Think-aloud protocols were collected to determine the problem-solving strategy used by experts and non-experts in answering Gastroenterology questions, across the two pencil-and-paper formats. The two formats demonstrated equal ability in testing problem-solving abilities, while the number of alternatives did not significantly impact psychometrics or problem-solving strategies utilized. These results support the notion that well-constructed multiple-choice questions can in fact test higher order clinical reasoning. Furthermore, it can be concluded that in testing clinical reasoning, the question stem, or content, remains more important than the number of alternatives.

Format of Options in Multiple Choice Test vis-a-vis Test Performance

ERIC Educational Resources Information Center

Bendulo, Hermabeth O.; Tibus, Erlinda D.; Bande, Rhodora A.; Oyzon, Voltaire Q.; Milla, Norberto E.; Macalinao, Myrna L.

2017-01-01

Testing or evaluation in an educational context is primarily used to measure or evaluate and authenticate the academic readiness, learning advancement, acquisition of skills, or instructional needs of learners. This study tried to determine whether the varied combinations of arrangements of options and letter cases in a Multiple-Choice Test (MCT)…

76 FR 76788 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-08

... price (e.g., the series might be quoted no bid).\\7\\ \\5\\ See Securities Exchange Act Release Nos. 59188... Options Audit Trail (``COATS'') requirements of Exchange Rule 6.24, Required Order Information. However... format as the COATS data is maintained. In this regard, all transactions for less than $1 must be...

76 FR 27110 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... even at the $1 cabinet price (e.g., the series might be quoted no bid).\\7\\ \\5\\ See Securities Exchange..., the transactions are exempt from the Consolidated Options Audit Trail (``COATS'') requirements of... transaction information for the transactions in the same format as the COATS data is maintained. In this...

Hispanic Cultural Theme Studies for Elementary Schools.

ERIC Educational Resources Information Center

Arata, Luis O.

These materials provide narratives about selected topics of cultural importance in the Hispanic world from the pre-Columbian past until after the Spanish conquest. The materials are designed for enrichment of current programs, and can be used in a variety of areas by elementary school teachers. The topics are treated in a story format so that…

Information retrieval system utilizing wavelet transform

DOEpatents

Brewster, Mary E.; Miller, Nancy E.

2000-01-01

A method for automatically partitioning an unstructured electronically formatted natural language document into its sub-topic structure. Specifically, the document is converted to an electronic signal and a wavelet transform is then performed on the signal. The resultant signal may then be used to graphically display and interact with the sub-topic structure of the document.

Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review

PubMed Central

Lozano-Carrascal, Naroa; Hernández-Alfaro, Federico; Gehrke, Sergio-Alexandre; Gargallo-Albiol, Jordi; Calvo-Guirado, José-Luis

2017-01-01

Background The aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology. Material and Methods An electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles dated from January 2000 to December 2016. Two reviewers assessed the quality of the studies independently. Results A total of 154 abstracts were identified, of which 18 potentially relevant articles were selected; a final total of nine papers were included for analysis. Comparison of the findings of the selected studies was made difficult by the heterogeneity of the articles, all of them animal research papers that showed heterogeneity in the methodologies used and a high or moderate risk of bias. Conclusions The topical application of bisphosphonate solution would appear to favor new bone formation in alveolar defects, and boosts the regenerative capacities of biomaterials resulting in increased bone density. Key words:Alveolar bone, bone regeneration, topical application, biomaterial, bisphosphonates. PMID:28624840

A pilot evaluation of text display formats for weather information in the cockpit

DOT National Transportation Integrated Search

1995-10-01

This study focuses on the weather (WX) services portion of Data Link. A : two-phase evaluation was conducted with 16 air transport (ATP) and general : aviation (GA) pilots. The pilots evaluated four data formatting options and : four data entry metho...

[Surgery for age-related macular degeneration. Still an option in the age of pharmacotherapy?].

PubMed

Joussen, A M; Kirchhof, B

2014-09-01

This review assesses the relevance of surgical approaches for age-related macular degeneration (AMD) with respect to the pathophysiology of AMD and the current pharmacological possibilities. We discuss the different surgical approaches such as subretinal membrane excision, cell transplantation (IPE and RPE) and transplantation of retina and choroid (PATCH), as well as translocation surgery. Peeling of epiretinal membranes in patients with drusen as well as vitrectomy before epiretinal brachytherapy (VIDEON system) are the final topics. While overall pharmacotherapy has displaced surgical approaches, surgery is worthy of consideration in selected cases. For these patients surgical options need to be maintained in the armamentarium of retinal surgeons. Georg Thieme Verlag KG Stuttgart · New York.

Patient Protection and Affordable Care Act; HHS Notice of Benefit and Payment Parameters for 2018; Amendments to Special Enrollment Periods and the Consumer Operated and Oriented Plan Program. Final rule.

PubMed

2016-12-22

This final rule sets forth payment parameters and provisions related to the risk adjustment program; cost-sharing parameters and cost-sharing reductions; and user fees for Federally-facilitated Exchanges and State-based Exchanges on the Federal platform. It also provides additional guidance relating to standardized options; qualified health plans; consumer assistance tools; network adequacy; the Small Business Health Options Programs; stand-alone dental plans; fair health insurance premiums; guaranteed availability and guaranteed renewability; the medical loss ratio program; eligibility and enrollment; appeals; consumer-operated and oriented plans; special enrollment periods; and other related topics.

[Extemporaneous magistral formulas for the topical treatment of pruritus : Proven and new options].

PubMed

Staubach, P; Weisshaar, E

2016-08-01

The treatment of pruritus, primarily chronic pruritus, is often difficult and must be treated simultaneously with the cause of pruritus and the individual demands of the skin. Due to the chronicity, a combination of systemic therapies, different active ingredients and basic formulas must be used in local therapies and adjusted during the course of the treatment. There are still therapeutic gaps, which can be closed by the use of extemporaneous preparations. Magistral formulas, which are already checked for plausibility, should be preferred over individual prescriptions. In the following, different therapeutic options in daily practice by using extemporaneous formulas from the NRF (New German Pharmacopoeia for compounded medications) are presented.

Health facility challenges to the provision of Option B+ in western Kenya: a qualitative study

PubMed Central

Akama, Eliud; Bukusi, Elizabeth A; Musoke, Pamela; Nalwa, Wafula Z; Odeny, Thomas A; Onono, Maricianah; Spangler, Sydney A; Turan, Janet M; Wanga, Iris; Abuogi, Lisa L

2017-01-01

Current WHO guidelines recommend lifelong antiretroviral therapy (ART) for all HIV-positive individuals, including pregnant and breastfeeding women (Option B+) in settings with generalized HIV epidemics. While Option B+ is scaled-up in Kenya, insufficient adherence and retention to care could undermine the expected positive impact of Option B+. To explore challenges to the provision of Option B+ at the health facility level, we conducted forty individual gender-matched in-depth interviews with HIV-positive pregnant/postpartum women and their male partners, and four focus groups with thirty health care providers at four health facilities in western Kenya between September-November 2014. Transcripts were coded with the Dedoose software using a coding framework based on the literature, topics from interview guides, and emerging themes from transcripts. Excerpts from broad codes were then fine-coded using an inductive approach. Three major themes emerged: 1) Option B+ specific challenges (same-day initiation into treatment, health care providers unconvinced of the benefits of Option B+, insufficient training); 2) facility resource constraints (staff and drug shortages, long queues, space limitations); and 3) lack of client-friendly services (scolding of patients, inconvenient operating hours, lack of integration of services, administrative requirements). This study highlights important challenges at the health facility level related to Option B+ rollout in western Kenya. Addressing these specific challenges may increase linkage, retention and adherence to life-long ART treatment for pregnant HIV-positive women in Kenya, contribute towards elimination of mother-to-child HIV transmission, and improve maternal and child outcomes. PMID:28207061

Health facility challenges to the provision of Option B+ in western Kenya: a qualitative study.

PubMed

Helova, Anna; Akama, Eliud; Bukusi, Elizabeth A; Musoke, Pamela; Nalwa, Wafula Z; Odeny, Thomas A; Onono, Maricianah; Spangler, Sydney A; Turan, Janet M; Wanga, Iris; Abuogi, Lisa L

2017-03-01

Current WHO guidelines recommend lifelong antiretroviral therapy (ART) for all HIV-positive individuals, including pregnant and breastfeeding women (Option B+) in settings with generalized HIV epidemics. While Option B+ is scaled-up in Kenya, insufficient adherence and retention to care could undermine the expected positive impact of Option B+. To explore challenges to the provision of Option B+ at the health facility level, we conducted forty individual gender-matched in-depth interviews with HIV-positive pregnant/postpartum women and their male partners, and four focus groups with thirty health care providers at four health facilities in western Kenya between September-November 2014. Transcripts were coded with the Dedoose software using a coding framework based on the literature, topics from interview guides, and emerging themes from transcripts. Excerpts from broad codes were then fine-coded using an inductive approach. Three major themes emerged: 1) Option B+ specific challenges (same-day initiation into treatment, health care providers unconvinced of the benefits of Option B+, insufficient training); 2) facility resource constraints (staff and drug shortages, long queues, space limitations); and 3) lack of client-friendly services (scolding of patients, inconvenient operating hours, lack of integration of services, administrative requirements). This study highlights important challenges at the health facility level related to Option B+ rollout in western Kenya. Addressing these specific challenges may increase linkage, retention and adherence to life-long ART treatment for pregnant HIV-positive women in Kenya, contribute towards elimination of mother-to-child HIV transmission, and improve maternal and child outcomes.

Analysing Costs/Benefits for Distance Education Programmes. Knowledge Series: A Topical, Start-Up Guide to Distance Education Practice and Delivery.

ERIC Educational Resources Information Center

Rumble, Greville

Cost analysis makes it possible to establish how much things costs, set budgets, determine prices, and compare the costs of different options. In distance education (DE), the main areas of cost analysis are as follows: print-based correspondence systems; educational/institutional television and radio systems; multimedia systems, and e-education…

45 CFR Appendix B to Part 1356 - NYTD Youth Outcome Survey

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false NYTD Youth Outcome Survey B Appendix B to Part... APPLICABLE TO TITLE IV-E Pt. 1356, App. B Appendix B to Part 1356—NYTD Youth Outcome Survey Topic/element No. Question to youth and response options Definition INFORMATION TO COLLECT FROM ALL YOUTH SURVEYED FOR...

45 CFR Appendix B to Part 1356 - NYTD Youth Outcome Survey

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false NYTD Youth Outcome Survey B Appendix B to Part... APPLICABLE TO TITLE IV-E Pt. 1356, App. B Appendix B to Part 1356—NYTD Youth Outcome Survey Topic/element No. Question to youth and response options Definition INFORMATION TO COLLECT FROM ALL YOUTH SURVEYED FOR...

45 CFR Appendix B to Part 1356 - NYTD Youth Outcome Survey

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false NYTD Youth Outcome Survey B Appendix B to Part... APPLICABLE TO TITLE IV-E Pt. 1356, App. B Appendix B to Part 1356—NYTD Youth Outcome Survey Topic/element No. Question to youth and response options Definition INFORMATION TO COLLECT FROM ALL YOUTH SURVEYED FOR...

Physics of Communication Minicourse, Career Oriented Pre-Technical Physics. Preliminary Edition.

ERIC Educational Resources Information Center

Bullock, Bob; And Others

This minicourse was prepared for use with secondary physics students in the Dallas Independent School District and is one option in a physics program which provides for the selection of topics on the basis of student career needs and interests. This minicourse was aimed at providing students with a knowledge of the ways in which light, sound, and…

Ballistics, Bullets and Blood Minicourse, Career Oriented Pre-Technical Physics. Preliminary Edition.

ERIC Educational Resources Information Center

Bullock, Bob; And Others

This minicourse was prepared for use with secondary physics students in the Dallas Independent School District and is one option in a physics program which provides for the selection of topics on the basis of student career needs and interests. This minicourse was aimed at providing the student with an understanding of the physics of falling…

Analyzing Early At-Risk Factors in Higher Education E-Learning Courses

ERIC Educational Resources Information Center

Baker, Ryan S.; Lindrum, David; Lindrum, Mary Jane; Perkowski, David

2015-01-01

College students enrolled in online courses lack many of the supports available to students in traditional face-to-face classes on a campus such as meeting the instructor, having a set class time, discussing topics in-person during class, meeting peers and having the option to speak with them outside of class, being able to visit faculty during…

Changing Your Domain Name in 25 Nail-Biting Steps

ERIC Educational Resources Information Center

Hassler, Carol

2012-01-01

When staff at the Wisconsin State Law Library began compiling a wish list for a new website, the topic of a new domain name came up almost immediately. Their old website was located at http://wsll.state.wi.us. Spelling that relatively complex domain over the phone day after day provided the impetus to explore other options. Whatever domain name…

Transition for Persons with Deaf-Blindness and Other Profound Handicaps: State of the Art. Section I. Community Based Residential Options.

ERIC Educational Resources Information Center

Romer, Lyle T.; And Others

This compilation brings together various conference papers and a working group report on the topic of residential services for people with deaf-blindness and other profound disabilities. The title paper by Lyle T. Romer describes three measures for evaluating residential programs: capacity, progress, and lifestyle. Valued outcomes of a residential…

School Consolidation: Is Bigger Better? Part I. Options in Education, Program #89.

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC. Inst. for Educational Leadership.

This publication is the complete transcript of a weekly radio program devoted to contemporary issues in American education. This particular program is the first of two that focus on the topic of school consolidation. In separate segments of the program, a teacher and students drill in a one-room school in Indiana; a long-time rural school teacher…

Probing the Natural World, Level III, Teacher's Edition: Investigating Variation. Intermediate Science Curriculum Study.

ERIC Educational Resources Information Center

Bonar, John R., Ed.; Hathway, James A., Ed.

This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on diversity in human populations, measurement, and data collection. Optional excursions are described for students who wish to study a topic in greater depth. An introduction describes…

Physics of Musical Instruments Minicourse, Career Oriented Pre-Technical Physics. Preliminary Edition.

ERIC Educational Resources Information Center

Bullock, Bob; And Others

This minicourse was prepared for use with secondary physics students in the Dallas Independent School District and is one option in a physics program which provides for the selection of topics on the basis of student career needs and interests. This minicourse was aimed at providing students with a knowledge of the technical descriptions of music,…

The Beneficial Effects of Non-Received Choice: A Study on Intrinsic Motivation in Biology Education

ERIC Educational Resources Information Center

Meyer, Annika; Meyer-Ahrens, Inga; Wilde, Matthias

2013-01-01

Previous research has found conflicting evidence in studies where students participate in the selection of their course topics in educational settings. Katz and Assor (2007), for example, have argued that the increase in student motivation is probably not due to the mere act of choosing, but to the value of the options with respect to personal…

Dendritic Macromer Replaces Sutures in Cataract Surgery; Promising Polymer Therapy for Paralyzed Dogs; Compound in Smoke Provides the Spark for Germination

NASA Astrophysics Data System (ADS)

King, Angela G.

2005-03-01

This Report surveys articles of interest to chemists that have been recently published in other science journals. Topics surveyed include reports that hydrogel offers an option to suturing the eye; polyethylene glycol aids recovery from spinal injury; and a compound in smoke increases germination rates. See Featured Molecules .

Therapeutic hypothermia as a bridge to transplantation in patients with fulminant hepatic failure

PubMed Central

Castillo, Luis; Bugedo, Guillermo; Rovegno, Max

2015-01-01

The most important topics in fulminant hepatic failure are cerebral edema and intracranial hypertension. Among all therapeutic options, systemic induced hypothermia to 33 - 34ºC has been reported to reduce the high pressure and increase the time during which patients can tolerate a graft. This review discusses the indications and adverse effects of hypothermia. PMID:25909316

Experiential Learning of History through Youth Journeys to Poland: Israeli Jewish Youth and the Holocaust

ERIC Educational Resources Information Center

Romi, Shlomo; Lev, Michal

2007-01-01

National history and collective memory and their impact on adolescents' knowledge and attitudes are the topic of this article. A follow-up study, it examines the long-term impact of a journey to historical monuments. Israeli Jewish high-school students have the option of experiential study, visiting cities and death camps in Poland. The first…

Topic Areas to Consider when Planning Transition from High School to Postsecondary Education for Students with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Roberts, Kelly D.

2010-01-01

For many individuals with an autism spectrum disorder (ASD), attending and completing postsecondary education is a viable option. However, success in postsecondary education for these individuals may require more planning and ongoing support than students without an ASD. This article provides educators and transition support personnel with a range…

The Use of Nuclear Propulsion, Power and 'In-Situ' Resources for Routine Lunar Space Transportation and Commercial Base Development

NASA Technical Reports Server (NTRS)

Borowski, Stanley K.

2003-01-01

This viewgraph presentation illustrates possible future strategies for solar system exploration supported by Nuclear Thermal Rocket (NTR) Propulsion. Topics addressed in the presentation include: lunar mining, Liquid Oxygen (LOX) augmented NTR (LANTR), 'Shuttle-Derived' Heavy Lift Vehicle (SDHLV) options for future human Lunar missions, and lunar-produced oxygen (LUNOX).

Biology: A Secondary School Syllabus with Major Emphasis on Fundamental Concepts. 1976 Reprint.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of General Education Curriculum Development.

This syllabus, which has evolved from the New York State Experimental Biology program, includes a basic core and six optional extended areas designed to be interesting and meaningful to the types of students currently taking the Regents Examination in Biology. The seven core unit topics are: (1) The Study of Life; (2) Maintenance in Animals; (3)…

College Today, Part III: College Closings. Options in Education Transcript: Program No. 121.

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC. Inst. for Educational Leadership.

The closing of a college is the topic of the third in a series of four transcripts of radio programs on college today. The dialogue includes: a press conference at Lone Mountain College, with a discussion of financial problems by the president and comments by Lone Mountain's student body president, college vice president, art department chairman,…

To Stream or Not to Stream in a Quantitative Business Course

ERIC Educational Resources Information Center

Buhagiar, Tarek; Potter, Robert

2010-01-01

This paper investigates whether there is a difference in student learning in a quantitative business course taught through video streaming with the option of going to a face-to-face lecture, compared to the same course taught only through face-to-face lecture. This topic has been the subject of research in recent years because of the importance of…

Proceedings of the 1999 Oil and Gas Conference: Technology Options for Producer Survival

DOE Office of Scientific and Technical Information (OSTI.GOV)

None available

2000-04-12

The 1999 Oil & Gas Conference was cosponsored by the U.S. Department of Energy (DOE), Office of Fossil Energy, Federal Energy Technology Center (FETC) and National Petroleum Technology Office (NPTO) on June 28 to 30 in Dallas, Texas. The Oil & Gas Conference theme, Technology Options for Producer Survival, reflects the need for development and implementation of new technologies to ensure an affordable, reliable energy future. The conference was attended by nearly 250 representatives from industry, academia, national laboratories, DOE, and other Government agencies. Three preconference workshops (Downhole Separation Technologies: Is it Applicable for Your Operations, Exploring and developing Naturallymore » Fractured Low-Permeability Gas Reservoirs from the Rocky Mountains to the Austin Chalk, and Software Program Applications) were held. The conference agenda included an opening plenary session, three platform sessions (Sessions 2 and 3 were split into 2 concurrent topics), and a poster presentation reception. The platform session topics were Converting Your Resources Into Reserves (Sessions 1 and 2A), Clarifying Your Subsurface Vision (Session 2B), and High Performance, Cost Effective Drilling, Completion, Stimulation Technologies (Session 3B). In total, there were 5 opening speakers, 30 presenters, and 16 poster presentations.« less

The influence of an elective introductory clinical research course on pharmacy student interest in pursuing research-based careers.

PubMed

Overholser, Brian R; Foster, David R; Henry, Joshua R; Plake, Kimberly S; Sowinski, Kevin M

2010-11-10

To assess the impact of an elective clinical research course on second- and third-year pharmacy students' knowledge of clinical research methods, training programs, career options, and interest in pursuing postgraduate training. A 2-credit hour elective course in clinical research was designed that included lectures, discussions, workshops, and in-class presentations related to study design and implementation, protocol synthesis, research evaluation, ethical and legal considerations, data analysis, and professional opportunities involving clinical research. Learner knowledge of these topics was assessed using several methods, including 3 assignments related to research protocol, ethical documentation, and presentation. A survey instrument designed to evaluate the effect the course had on pharmacy students' knowledge of clinical research methods and interest in pursuing postgraduate training in clinical research was administered. Students who completed the elective had a greater level of familiarity with research-related topics, training options, and career opportunities (p < 0.05) and a greater interest in pursuing a career in clinical research (p < 0.05) than did students in a matched control group. Taking a 2-credit hour elective course in clinical research increased pharmacy students' interest in pursuing a career in clinical research.

A new Model for the Preparing for an Academic Career in the Geosciences Workshop

NASA Astrophysics Data System (ADS)

Gilbert, L. A.; Marin-Spiotta, E.; LeMay, L.; Reed, D. E.; Desai, A. R.; Macdonald, H.

2016-12-01

The NAGT/On the Cutting Edge program has offered annual workshops on Preparing for an Academic Career in the Geosciences since 2003, providing professional development for more than 800 graduate students and post-docs. In July 2016, the multi-day workshop was modified to be integrated into a larger conference, the Earth Educators' Rendezvous. This new format brought both challenges and opportunities. Like prior workshops, participants engaged with peers and workshop leaders from a range of educational settings to improve their application and interview skills for academic jobs, become more effective at goal-setting and time management, and broaden their network of colleagues and resources to jump-start teaching and research as a faculty member. They learned about academic careers in different educational settings (two-year colleges, primarily undergraduate institutions, and research-focused universities), and developed plans and goals for their next career stage. The biggest challenge of the new workshop format was paring down material from 2.5 full days. Thus, in addition to the 3 morning sessions allocated for the workshop, leaders added a 3-hour teaching statement review dinner, an optional evening session to discuss finances and work-life balance, and optional small group lunch discussions on all 3 days, which were all well attended. Participants were then able to take advantage of afternoon sessions at the Rendezvous, including demonstrations of exemplary teaching, plenary talks, poster sessions, and mini-workshops on topics from curriculum design to proposal writing. Participant reviews were positive and nearly all aspects were ranked as most valuable, with an overall satisfaction mean of 9.1 on a scale from 1-10, with 10 being "Very satisfied." Participants particularly valued the sessions related to careers and the job search process. Some wished the workshop had been longer to cover more material. Participants enjoyed the opportunity to gain more skills at the Rendezvous afternoon sessions and several participants mentioned the Rendezvous afforded them the possibility of attending the Career Prep workshop. Our experiment showed that a career preparation workshop can survive when embedded into a larger conference.

Effects of Topical Anesthetics on Pullularia pullulans and Debaryomyces hansenii

PubMed Central

Merdinger, Emanuel; Guthmann, Walter S.; Mangine, Francis W.

1969-01-01

The inhibitory effects of three topical anesthetics of various concentrations on the growth of Pullularia pullulans, Debaryomyces hansenii, and on pigment production by P. pullulans were investigated. The topical anesthetics were benoxinate hydrochloride, proparacaine hydrochloride, and tetracaine hydrochloride. In decreasing order, the inhibiting effects of the drugs on growth were benoxinate, tetracaine, and proparacaine for P. pullulans, and tetracaine, benoxinate, and proparacaine for D. hansenii. The pigment formation in P. pullulans was inhibited by the three drugs. PMID:5392897

Treatment of rosacea.

PubMed

Parodi, A; Drago, F; Paolino, S; Cozzani, E; Gallo, R

2011-11-01

A range of treatment options are available in rosacea, which include several topical (mainly metronidazole, azelaic acid, other antibiotics, sulfur, retinoids) and oral drugs (mainly tetracyclines, metronidazole, macrolides). In some cases, the first choice is a systemic therapy because patients may have sensitive skin and topical medications can be irritant. Isotretinoin can be used in resistant cases of rosacea. Unfortunately, the majority of studies on rosacea treatments are at high or unclear risk of bias. A recent Cochrane review found that only topical metronidazole, azelaic acid, and oral doxycycline (40 mg) had some evidence to support their effectiveness in moderate to severe rosacea and concluded that further well-designed, adequately-powered randomised controlled trials are required. In our practice, we evaluate our patients for the presence of two possible triggers, Helicobacter pylori infection and small intestinal bacterial overgrowth. When they are present we use adapted antibiotic protocols. If not, we use oral metronidazole or oral tetracycline to treat papulopustolar rosacea. We also look for Demodex folliculorum infestation. When Demodex concentration is higher than 5/cm(2) we use topical crotamiton 10% or metronidazole. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

[Treatment of rosacea].

PubMed

Parodi, A; Drago, F; Paolino, S; Cozzani, E; Gallo, R

2011-09-01

A range of treatment options are available in rosacea, which include several topical (mainly metronidazole, azelaic acid, other antibiotics, sulfur, retinoids) and oral drugs (mainly tetracyclines, metronidazole, macrolides). In some cases, the first choice is a systemic therapy because patients may have sensitive skin and topical medications can be irritant. Isotretinoin can be used in resistant cases of rosacea. Unfortunately, the majority of studies on rosacea treatments are at high or unclear risk of bias. A recent Cochrane review found that only topical metronidazole, azelaic acid, and oral doxycycline (40 mg) had some evidence to support their effectiveness in moderate to severe rosacea and concluded that further well-designed, adequately-powered randomised controlled trials are required. In our practice, we evaluate our patients for the presence of two possible triggers, Helicobacter pylori infection and small intestinal bacterial overgrowth. When they are present we use adapted antibiotic protocols. If not, we use oral metronidazole or oral tetracycline to treat papulopustolar rosacea. We also look for Demodex folliculorum infestation. When Demodex concentration is higher than 5/cm(2) we use topical crotamiton 10% or metronidazole. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Formation and antimicrobial activity of complexes of beta-cyclodextrin and some antimycotic imidazole derivatives.

PubMed

Van Doorne, H; Bosch, E H; Lerk, C F

1988-04-22

Complex formation between beta-cyclodextrin and six antimycotic imidazole derivatives has been studied. The solubility of all drugs was increased in the presence of beta-cyclodextrin. The smallest increase (approx. 5-fold) was observed for miconazol, and the largest increase (approx. 160-fold) was observed for bifonazol. Apparent 1:1-complex constants were measured and found to decrease in the order: bifonazol greater than ketoconazol greater than tioconazol greater than miconazol greater than itraconazol greater than clotrimazol. The complexes appeared to possess a low, if any, antimicrobial activity. Measurement of inhibition zone sizes, with four test organisms was used to study the release of the antimycotic drugs from topical preparations. The antimycotic drugs were more readily released from topical preparations containing beta-cyclodextrin than from the same vehicles without beta-cyclodextrin. The rationale of beta-cyclodextrin addition to antimycotic topical preparations is discussed.

Active-learning Strategies for Legal Topics and Substance Abuse in a Pharmacy Curriculum.

PubMed

Steinhardt, Sarah J; Clark, John E; Kelly, William N; Hill, Angela M

2017-02-25

Objective. To implement active-learning strategies to engage students in learning, applying, and teaching legal and substance abuse topics. Design. Medication Safety course student groups created films on a National Patient Safety Goal (NPSG) using a movie genre and presented them in film festival format. Pharmacogenomics course student groups taught ethical, legal, and social implications (ELSI) topics through presentation of short stories about comic book characters with genetic mutations. Students in the Drugs of Abuse course composed and performed dances depicting the mechanism of action of a drug in an in-class rave dance format. Assessment. Course evaluations revealed student engagement with subject material and enjoyment of the creative applications, critical thinking, and collaborative aspects of the activities. Students performed well on examination questions and graded assignments. Conclusion. These active-learning strategies facilitated students' abilities to learn, apply, and teach material in medication safety, pharmacogenomics, and substance abuse courses.

Active-learning Strategies for Legal Topics and Substance Abuse in a Pharmacy Curriculum

PubMed Central

Clark, John E.; Kelly, William N.; Hill, Angela M.

2017-01-01

Objective. To implement active-learning strategies to engage students in learning, applying, and teaching legal and substance abuse topics. Design. Medication Safety course student groups created films on a National Patient Safety Goal (NPSG) using a movie genre and presented them in film festival format. Pharmacogenomics course student groups taught ethical, legal, and social implications (ELSI) topics through presentation of short stories about comic book characters with genetic mutations. Students in the Drugs of Abuse course composed and performed dances depicting the mechanism of action of a drug in an in-class rave dance format. Assessment. Course evaluations revealed student engagement with subject material and enjoyment of the creative applications, critical thinking, and collaborative aspects of the activities. Students performed well on examination questions and graded assignments. Conclusion. These active-learning strategies facilitated students’ abilities to learn, apply, and teach material in medication safety, pharmacogenomics, and substance abuse courses. PMID:28289294

Hair loss and regeneration performed on animal models

PubMed Central

ORASAN, MEDA SANDRA; ROMAN, IULIA IOANA; CONEAC, ANDREI; MURESAN, ADRIANA; ORASAN, REMUS IOAN

2016-01-01

Research in the field of reversal hair loss remains a challenging subject. As Minoxidil 2% or 5% and Finasteride are so far the only FDA approved topical treatments for inducing hair regrowth, research is necessary in order to improve therapeutical approach in alopecia. In vitro studies have focused on cultures of a cell type - dermal papilla or organ culture of isolated cell follicles. In vivo research on this topic was performed on mice, rats, hamsters, rabbits, sheep and monkeys, taking into consideration the advantages and disadvantages of each animal model and the depilation options. Further studies are required not only to compare the efficiency of different therapies but more importantly to establish their long term safety. PMID:27547051

Evaluation of topical application and systemic administration of rosuvastatin in preventing epidural fibrosis in rats.

PubMed

Gürer, Bora; Kahveci, Ramazan; Gökçe, Emre Cemal; Ozevren, Huseyin; Turkoglu, Erhan; Gökçe, Aysun

2015-03-01

Epidural fibrosis is a major challenge in spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. One of the most important factors initiating the epidural fibrosis is assumed to be the transforming growth factor-1β (TGF-1β). Rosuvastatin (ROS) has shown to demonstrate preventive effects over fibrosis via inhibiting the TGF-1β. We hypothesized that ROS might have preventive effects over epidural fibrosis through the inhibition of TGF-1β pathways. Experimental animal study. Forty-eight adult male Wistar Albino rats were equally and randomly divided into four groups (laminectomy, spongostan, topical ROS, and systemic ROS). Laminectomy was performed at the L3 level in all rats. Four weeks later, the extent of epidural fibrosis was assessed both macroscopically and histopathologically. Our data revealed that topical application and systemic administration of ROS both were effective in reducing epidural fibrosis formation. Furthermore, the systemic administration of ROS yielded better results than topical application. Both topical application and systemic administration of ROS show meaningful preventive effects over epidural fibrosis through multiple mechanisms. The results of our study provide the first experimental evidence of the preventive effects of ROS over epidural fibrosis. Copyright © 2015 Elsevier Inc. All rights reserved.

Representational task formats and problem solving strategies in kinematics and work

NASA Astrophysics Data System (ADS)

Ibrahim, Bashirah; Rebello, N. Sanjay

2012-06-01

Previous studies have reported that students employed different problem solving approaches when presented with the same task structured with different representations. In this study, we explored and compared students’ strategies as they attempted tasks from two topical areas, kinematics and work. Our participants were 19 engineering students taking a calculus-based physics course. The tasks were presented in linguistic, graphical, and symbolic forms and requested either a qualitative solution or a value. The analysis was both qualitative and quantitative in nature focusing principally on the characteristics of the strategies employed as well as the underlying reasoning for their applications. A comparison was also made for the same student’s approach with the same kind of representation across the two topics. Additionally, the participants’ overall strategies across the different tasks, in each topic, were considered. On the whole, we found that the students prefer manipulating equations irrespective of the representational format of the task. They rarely recognized the applicability of a “qualitative” approach to solve the problem although they were aware of the concepts involved. Even when the students included visual representations in their solutions, they seldom used these representations in conjunction with the mathematical part of the problem. Additionally, the students were not consistent in their approach for interpreting and solving problems with the same kind of representation across the two topical areas. The representational format, level of prior knowledge, and familiarity with a topic appeared to influence their strategies, their written responses, and their ability to recognize qualitative ways to attempt a problem. The nature of the solution does not seem to impact the strategies employed to handle the problem.

Formation and Origin of Metabreccia from the Parkin Offset Dyke at the Sudbury Impact Structure

NASA Astrophysics Data System (ADS)

Anders, D.; Osinski, G. R.; Grieve, R. A. F.; Péntek, A.

2015-09-01

Metabreccia is an important litholgy of the Offset Dykes of the Sudbury impact structure, however, its formation and origin is still topic of discussion. Here we present evidence that Metabreccia is a metamorphosed Footwall Breccia.

A Simple Explanation of Complexation

ERIC Educational Resources Information Center

Elliott, J. Richard

2010-01-01

The topics of solution thermodynamics, activity coefficients, and complex formation are introduced through computational exercises and sample applications. The presentation is designed to be accessible to freshmen in a chemical engineering computations course. The MOSCED model is simplified to explain complex formation in terms of hydrogen…

77 FR 35095 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

... price (e.g., the series might be quoted no bid).\\7\\ \\5\\ See Securities Exchange Act Release Nos. 59188... exempt from the Consolidated Options Audit Trail (``COATS'') requirements of Exchange Rule 6.24, Required... transactions in the same format as the COATS data is maintained. In this regard, all transactions for less than...

Functional assessment and treatment of perseverative speech about restricted topics in an adolescent with Asperger syndrome.

PubMed

Fisher, Wayne W; Rodriguez, Nicole M; Owen, Todd M

2013-01-01

A functional analysis showed that a 14-year-old boy with Asperger syndrome displayed perseverative speech (or "restricted interests") reinforced by attention. To promote appropriate speech in a turn-taking format, we implemented differential reinforcement (DR) of nonperseverative speech and DR of on-topic speech within a multiple schedule with stimuli that signaled the contingencies in effect and who was to select the topic. Both treatments reduced perseverative speech, but only DR of on-topic speech increased appropriate turn taking during conversation. Treatment effects were maintained when implemented by family members and novel therapists. © Society for the Experimental Analysis of Behavior.

Children’s recalls from five dietary-reporting validation studies: Intrusions in correctly reported and misreported options in school breakfast reports

PubMed Central

Baxter, Suzanne Domel; Hardin, James W.; Royer, Julie A.; Guinn, Caroline H.; Smith, Albert F.

2008-01-01

For school breakfast each day, many elementary schools offer a choice between a cold option that includes ready-to-eat (RTE) cereal and a hot option that includes a non-RTE-cereal entrée such as waffles. For breakfast reports, intrusions (reports of uneaten items) in correctly reported and misreported breakfast options were examined using data from five dietary-reporting validation studies. In each study, fourth-grade children were observed eating school breakfast and school lunch and then interviewed to obtain a dietary recall. A breakfast option was correctly reported in 240 breakfast reports for 203 intrusions total, and misreported in 97 breakfast reports for 189 intrusions total. Asymmetry was evident in misreported options; specifically, children observed eating a cold option almost never misreported a hot option, but children observed eating a hot option often misreported a cold option. Proportionately more breakfast reports were intrusion-free when a breakfast option was correctly reported than misreported. Linking of intrusions (i.e., multiple intrusions from the same option in a breakfast report) was especially evident with misreported breakfast options. Methodological aspects of dietary recalls such as target period (prior 24 hours; previous day), interview time (morning; afternoon; evening), and interview format (meal; open) had implications for intrusions and misreported breakfast options. PMID:18501992

Beryllium Metal Supply Options

DTIC Science & Technology

1989-01-01

vacuum evaporator treatment to form ABF crystals, which are separated in a horizontal bowl centrifuge and dried. Formation of Beryllium Fluoride The...addition, the high viscosity of the slag may cause poor pebble formation and yield. Thus, the following programs to improve efficiency have been suggested...and avoiding the formation of beryllium fines, which are difficult to recover. The production of a readily manageable beryllium sponge is desired, which

Improvement in likelihood to donate blood after being offered a topical anesthetic.

PubMed

Watanabe, Kyle M; Jay, Jeffrey; Alicto, Christopher; Yamamoto, Loren G

2011-02-01

While there are many reasons people choose not to donate blood, pain sustained during the venipuncture portion of the blood donation process is likely one deterrent to volunteer donation. The purpose of this study was to survey the improvement in likelihood of donation if participants were given the option of a topical anesthetic cream prior to venipuncture. Over a three month period 316 adults (convenience sample) completed a one page survey consisting of twelve questions pertaining to blood donation. Participants were asked about their likelihood of donating blood in the near future (No Possibility, Possible, Likely, Certain). They were then informed of the possibility of using a topical anesthetic cream prior to donation. Subsequently, their likelihood of donating blood was reassessed. Fifty (16%) subjects reported an increased likelihood of donating blood if offered a topical anesthetic (p〈0.0001). Of these respondents reporting an increase in donation likelihood, eleven improved by 2 or more likelihood categories. Amongst the 169 participants who never donated blood, 34 (20%) reported an increased likelihood of donation after being told about the topical anesthetic cream, compared to 16 (10%) of the 147 subjects who had previously donated blood (p=0.02). The findings of this study suggest that providing a topical anesthetic had a positive effect on the study participants' likelihood of donating blood. This improvement was greater amongst those who have never donated blood. Hawaii Medical Journal Copyright 2011.

Topical anesthesia for penetrating trabeculectomy.

PubMed

Sauder, Gangolf; Jonas, Jost B

2002-09-01

To evaluate the efficacy and clinical practicability of topical anesthesia in comparison with retrobulbar anesthesia for penetrating trabeculectomy. The prospective single-surgeon clinical interventional trial included 20 consecutive patients, who were randomly distributed into a topical anesthesia group ( n=10) and a retrobulbar anesthesia group ( n=10). In the topical anesthesia group, patients received preoperatively oxybuprocaine 0.4% eye drops and cocaine hydrochloride eye drops 10%. The patients of the retrobulbar group received 5 ml mepivacaine 2% injected into the retrobulbar space. To assess intraoperative pain, each patient was asked immediately after surgery to quantitate his/her pain using a 10-point pain rating scale. The topical anesthesia group and the retrobulbar anesthesia study group did not vary significantly in duration of surgery (21.5+/-3.37 min vs 20.2+/-4.46 min, P=0.31), preoperative intraocular pressure (32.2+/-14.62 mmHg vs 30.6+/-12.33 mmHg, P=0.22), postoperative intraocular pressure (8.0+/-4.47 mmHg vs 9.12+/-3.13 mmHg, P=0.64), subjective pain score by the patient (2.25+/-1.23 relative units vs 2.33+/-1.08 relative units ( P= 0.71), and practicability score by the surgeon (2.24+/-1.76 vs 2.56+/-1.58, P=0.82). In view of its clinical feasibility and its minimally invasive character, topical anesthesia may be an option for penetrating trabeculectomy.

A Prospective, Randomized, Double-blind, Split-face Clinical Trial Comparing the Efficacy of Two Topical Human Growth Factors for the Rejuvenation of the Aging Face

PubMed Central

Goldman, Mitchel P.

2017-01-01

Background: Cosmeceutical products represent an increasingly important therapeutic option for anti-aging and rejuvenation, either used alone or in combination with dermatologic surgical procedures. Among this group of products, topical growth factors have demonstrated efficacy in randomized, controlled clinical trials. However, comparisons between different products remain uncommon. Objective: The objective of this randomized, double-blind, split-face clinical trial was to compare two different topical growth factor formulations derived from either human fibroblasts or human adipose tissue derived mesenchymal stem cells. Methods: This was an institutional review board-approved, randomized, double-blind, split-face clinical trial involving 20 healthy subjects with moderate-to-severe facial wrinkling secondary to photodamage. One half of the face was randomized to receive topical human fibroblast growth factors and the other topical human mesenchymal stem cell growth factors. Treatment was continued for three months, and evaluations were performed in a double-blind fashion. Results: Both growth factor formulations achieved significant improvement in facial wrinkling. Blinded investigator and subject evaluations did not detect any significant differences between the two formulations in terms of efficacy, safety, or tolerability. Conclusion: Both human fibroblast growth factors and human mesenchymal stem cell growth factors are effective at facial rejuvenation. Topical growth factors represent a useful therapeutic modality. PMID:28670356

A Prospective, Randomized, Double-blind, Split-face Clinical Trial Comparing the Efficacy of Two Topical Human Growth Factors for the Rejuvenation of the Aging Face.

PubMed

Wu, Douglas C; Goldman, Mitchel P

2017-05-01

Background: Cosmeceutical products represent an increasingly important therapeutic option for anti-aging and rejuvenation, either used alone or in combination with dermatologic surgical procedures. Among this group of products, topical growth factors have demonstrated efficacy in randomized, controlled clinical trials. However, comparisons between different products remain uncommon. Objective: The objective of this randomized, double-blind, split-face clinical trial was to compare two different topical growth factor formulations derived from either human fibroblasts or human adipose tissue derived mesenchymal stem cells. Methods: This was an institutional review board-approved, randomized, double-blind, split-face clinical trial involving 20 healthy subjects with moderate-to-severe facial wrinkling secondary to photodamage. One half of the face was randomized to receive topical human fibroblast growth factors and the other topical human mesenchymal stem cell growth factors. Treatment was continued for three months, and evaluations were performed in a double-blind fashion. Results: Both growth factor formulations achieved significant improvement in facial wrinkling. Blinded investigator and subject evaluations did not detect any significant differences between the two formulations in terms of efficacy, safety, or tolerability. Conclusion: Both human fibroblast growth factors and human mesenchymal stem cell growth factors are effective at facial rejuvenation. Topical growth factors represent a useful therapeutic modality.

Clinically localized prostate cancer in 2017: A review of comparative effectiveness.

PubMed

Lavery, Hugh J; Cooperberg, Matthew R

2017-02-01

Introducing the topic of comparative effectiveness for prostate cancer treatments with a reminder of the disease's heterogeneity risks tautology. However, the profound variation both in this cancer's biology and its clinical course is increasingly widely recognized, while management alternatives for clinically localized prostate cancer have exploded. Available options now include active surveillance, multiple surgical approaches to prostatectomy, various forms of external-beam and interstitial radiation, and a growing list of energy ablative technologies. Each treatment option has its own efficacy rate as well as its own set of complications, side effects and financial costs. Difficulties comparing these options, together with the high prevalence of the disease, led the Institute of Medicine to include localized prostate cancer among the top 25 priority conditions for future comparative effectiveness research. The sheer volume of possible treatment options, with their individual risks and benefits, can be confusing for patients and clinicians to research, understand and explain. To help clinicians navigate these treatment options, we have assembled this Urologic Oncology Seminar on the comparative effectiveness of treatments for clinically localized prostate cancer. The articles focus on high quality evidence-based medicine and most have included useful tables summarizing seminal trials and available resources. Copyright © 2017 Elsevier Inc. All rights reserved.

Schockmed Valve: A Novel Surgical Option for Uncontrolled Glaucoma in Eyes with Poor Conjunctiva and Encircling Bands.

PubMed

Fleischman, David; Kim, Bryan

2017-01-01

Surgical management of elevated intraocular pressure (IOP) in an eye with scarred conjunctiva, an encircling band, and silicone oil has limited options. By combining the flow restrictor of the Ahmed Glaucoma Valve (New World Medical, Rancho Cucamonga, California) and the capsule of the encircling band as a conduit for aqueous flow, immediate pressure reduction could theoretically be achieved in eyes with limited conjunctival mobilization. This is a description of a surgical technique in a case of a patient with multiple ocular surgeries with uncontrolled multimechanism glaucoma despite using all available topical and oral glaucoma medications. A combination of the Ahmed valve with a modification of the Schocket shunt technique was used in this case of an encircling band and poor conjunctiva. At 10-month follow-up, the patient maintains controlled pressures on dorzolamide-timolol drops. The combined Ahmed-Schocket (or Schockmed) technique may be another surgical option for management of uncontrolled IOP in cases of scarred conjunctiva and encircling bands needing immediate pressure reduction. A novel surgical option for uncontrolled glaucoma in eyes with poor conjunctiva and encircling bands. How to cite this article: Fleischman D, Kim B. Schockmed Valve: A Novel Surgical Option for Uncontrolled Glaucoma in Eyes with Poor Conjunctiva and Encircling Bands. J Curr Glaucoma Pract 2017;11(3):120-124.

Symptoms, Diagnosis, and Treatment of Cow's Milk Allergy.

PubMed

Vandenplas, Yvan; Marchand, Johan; Meyns, Lien

2015-01-01

The diagnosis and management of cow's milk allergy (CMA) is a topic of debate because there are no specific symptoms and reliable diagnostic tests. Literature was searched using databases to find original papers and reviews on this topic. A "challenge test" is still recommended as the most specific and sensitive diagnostic test, although a positive challenge test does not proof the involvement of the immune system. Only in the rare case of anaphylaxis, the challenge tests is not recommended. The Cow's Milk Symptom Score (CoMiSS) is an awareness tool for health care professionals to better recognize symptoms caused by the ingestion of cow's milk, but still needs validation. Today, the recommended diagnostic approach consists of an elimination diet with an extensive cow's milk based hydrolysate, followed by a challenge test. Amino acid based formula is reserved for the severe cases. Rice hydrolysates are gaining popularity, because they have been shown to be effective, have a better acceptability, and to be cheaper than the extensive cow's milk based hydrolysates. Soy infant formula may offer an additional alternative option as reviews concluded that about 10-15% of infants allergic to cow's milk will also react to soy. Gastro-intestinal microbiota manipulation may be of additional benefit in the treatment of CMA. The development of rice hydrolysates challenge the use of Today, extensive cow's milk based extensive hydrolysates remain the first option for the majority of patients and amino acid formula for the most severe cases. Rice hydrolysates and soy infant formula are considered as second choice options.

Heterogeneous Catalysis: On Bathroom Mirrors and Boiling Stones

ERIC Educational Resources Information Center

Philipse, Albert P.

2011-01-01

Though heterogeneous nucleation of liquid droplets on a smooth surface (such as a bathroom mirror) is a classical topic in nucleation theory, it is not well-known that this topic is actually a pedagogical example of heterogeneous catalysis: the one and only effect of the surface is to lower the activation Gibbs energy of droplet formation. In…

A Topic Analysis of ISECON Conference Proceedings from 1982 through 2014

ERIC Educational Resources Information Center

Clark, Jon; Athey, Susan; Plotnicki, Jon; Barnes, Jay

2016-01-01

The authors note a distinct shift in topics covered in curricula as well as in conference presentations. This research was undertaken to get a better understanding of what these shifts have been, and determine their magnitude over time. Since ISECON has published its conference proceedings in digital format since 1982, this was a logical source of…

Information retrieval system utilizing wavelet transform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brewster, M.E.; Miller, N.E.

A method is disclosed for automatically partitioning an unstructured electronically formatted natural language document into its sub-topic structure. Specifically, the document is converted to an electronic signal and a wavelet transform is then performed on the signal. The resultant signal may then be used to graphically display and interact with the sub-topic structure of the document.

Topical calcineurin inhibitors for atopic dermatitis: review and treatment recommendations.

PubMed

Carr, Warner W

2013-08-01

Atopic dermatitis (AD) is an inflammatory skin disease commonly affecting children and managed by pediatricians, primary care physicians, allergists, and dermatologists alike. For many years, the only available topical pharmacological treatment was topical corticosteroids. This changed in 2000-2001, when topical formulations of two calcineurin inhibitors (tacrolimus and pimecrolimus) were approved for short-term or chronic intermittent treatment of AD in patients ≥ 2 years of age, in whom other treatments have been ineffective or contraindicated. These topical calcineurin inhibitors (TCIs) quickly became a popular treatment option due at least in part to concerns over adverse events associated with prolonged topical corticosteroid use, especially in children. However, based on theoretical concerns about a possible risk of lymphoma associated with TCI use, a Boxed Warning was placed on both products in 2006. Since then, despite an extensive body of evidence, no causal relationship has been demonstrated between TCI use and an increased risk of lymphoma; however, the US FDA has concluded that a link cannot be ruled out. In fact, based on post-marketing surveillance of spontaneous, literature, and solicited reports, we report here that the lymphoma incidence in the topical pimecrolimus-exposed population is up to approximately 54-fold less than that seen in the general US population. This review summarizes the mechanism of action of TCIs, the factors that prompted the Boxed Warning, and recent TCI safety and efficacy data. Based on these data, both topical corticosteroids and TCIs should have defined roles in AD management, with TCIs favored for sensitive skin areas (e.g., face) and instances where topical corticosteroids have proven ineffective, thereby minimizing the risk of adverse effects with both drug classes.

Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch

PubMed Central

Lionberger, David R; Brennan, Michael J

2010-01-01

The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP) in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac, and DETP in patients with acute soft tissue injuries was included. Relevant literature was identified on MEDLINE using the search terms topical NSAIDs, diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, strain, sprain, and contusion, and from citations in retrieved articles covering the years 1978–2008. Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5–1.9). In a limited number of comparisons, topical and oral NSAIDs provided comparable pain relief, but the use of topical agents produced lower plasma drug concentrations and fewer systemic adverse events (AEs). The physical–chemical properties of diclofenac epolamine make it well suited for topical use. In patients with acute soft tissue injuries treated with DETP, clinical data report an analgesic benefit within hours of the first application, and significant pain relief relative to placebo within 3 days. Moreover, DETP displayed tolerability comparable with placebo; the most common AEs were pruritus and other application site reactions. Review of published literature suggests that DETP is generally safe and well tolerated, clinically efficacious, and a rational treatment option for patients experiencing acute pain associated with strains, sprains, and contusions, and other localized painful conditions. PMID:21197326

Formative Evaluation of a Neuroanatomy Course

ERIC Educational Resources Information Center

Sterret, Patrick R.; Littlefield, John H.

1976-01-01

Student cognitive performance data and affective reactions provided the basis for a formative evaluation of this neuroanatomy curriculum for freshmen medical students. The cerebral hempispheres topic area was marked by poor cognitive performance and low ratings in lecture quality. Videotapes designed to augment neurophysiology also received low…

Evaluation of Carbon Dioxide Laser in the Treatment of Epidermal Nevi.

PubMed

Bhat, Yasmeen Jabeen; Hassan, Iffat; Sajad, Peerzada; Yaseen, Atiya; Mubashir, Syed; Akhter, Saniya; Wani, Roohi

2016-01-01

Epidermal naevi are benign hamartomatous growths of the skin which are generally asymptomatic with a benign course but are cosmetically disagreeable. Topical treatments such as steroids, calcipotriol, 5 fluorouracil, podophyllin, retinoids and cryotherapy are ineffective and surgical excision results in scar formation. Therapy is often challenging. To study the response of carbon dioxide (CO 2 ) laser in the management of epidermal naevi. We conducted a study of CO 2 laser treatment on 15 patients of epidermal naevi, eight with verrucous epidermal naevi and seven with sebaceous naevi. A thorough history and examination was done to rule out any epidermal naevus syndrome. The diagnosis was confirmed by histopathology. The number of treatment sessions varied from 1 to 8. Response was excellent (>90% reduction in lesion size) in three patients, very good (>75% reduction) in five, good (>50% reduction in lesion size) in five and poor (<50% reduction in lesion size) in two patients. The side effects were hyperpigmentation and scarring. Long-term follow-up over a period of 10 months showed a recurrence rate of 20%. We conclude that CO 2 laser treatment might be an effective option with long-term safety, minimal discomfort and rapid recovery.

Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens

PubMed Central

Cieplik, Fabian; Tabenski, Laura; Buchalla, Wolfgang; Maisch, Tim

2014-01-01

With increasing numbers of antibiotic-resistant pathogens all over the world there is a pressing need for strategies that are capable of inactivating biofilm-state pathogens with less potential of developing resistances in pathogens. Antimicrobial strategies of that kind are especially needed in dentistry in order to avoid the usage of antibiotics for treatment of periodontal, endodontic or mucosal topical infections caused by bacterial or yeast biofilms. One possible option could be the antimicrobial photodynamic therapy (aPDT), whereby the lethal effect of aPDT is based on the principle that visible light activates a photosensitizer (PS), leading to the formation of reactive oxygen species, e.g., singlet oxygen, which induce phototoxicity immediately during illumination. Many compounds have been described as potential PS for aPDT against bacterial and yeast biofilms so far, but conflicting results have been reported. Therefore, the aim of the present review is to outline the actual state of the art regarding the potential of aPDT for inactivation of biofilms formed in vitro with a main focus on those formed by oral key pathogens and structured regarding the distinct types of PS. PMID:25161649

Automated Feedback as a Convergence Tool

ERIC Educational Resources Information Center

Chenoweth, Tim; Corral, Karen; Scott, Kit

2016-01-01

This study evaluates two content delivery options for teaching a programming language to determine whether an asynchronous format can achieve the same learning efficacy as a traditional lecture (face-to-face) format. We use media synchronicity theory as a guide to choose media capabilities to incorporate into an asynchronous tutorial used…

Offering Reflection to an Organization

ERIC Educational Resources Information Center

Faulkner, Ann; Gooding, Guy

2010-01-01

From 1998 to 2008, the Dallas County Community College District (DCCCD) offered its employees a variety of options for formation, a type of reflective practice. The district encompasses 10 locations, seven of them independently accredited colleges. Formation is based primarily on Parker Palmer's model for Circles of Trust as described in "A…

Dependency Tree Annotation Software

DTIC Science & Technology

2015-11-01

formats, and it provides numerous options for customizing how dependency trees are displayed. Built entirely in Java , it can run on a wide range of...tree can be saved as an image, .mxe (a mxGraph editing file), a .conll file, and several other file formats. DTE uses the open source Java version

NCBI GEO: mining tens of millions of expression profiles--database and tools update.

PubMed

Barrett, Tanya; Troup, Dennis B; Wilhite, Stephen E; Ledoux, Pierre; Rudnev, Dmitry; Evangelista, Carlos; Kim, Irene F; Soboleva, Alexandra; Tomashevsky, Maxim; Edgar, Ron

2007-01-01

The Gene Expression Omnibus (GEO) repository at the National Center for Biotechnology Information (NCBI) archives and freely disseminates microarray and other forms of high-throughput data generated by the scientific community. The database has a minimum information about a microarray experiment (MIAME)-compliant infrastructure that captures fully annotated raw and processed data. Several data deposit options and formats are supported, including web forms, spreadsheets, XML and Simple Omnibus Format in Text (SOFT). In addition to data storage, a collection of user-friendly web-based interfaces and applications are available to help users effectively explore, visualize and download the thousands of experiments and tens of millions of gene expression patterns stored in GEO. This paper provides a summary of the GEO database structure and user facilities, and describes recent enhancements to database design, performance, submission format options, data query and retrieval utilities. GEO is accessible at http://www.ncbi.nlm.nih.gov/geo/

An investigation into the optimal number of distractors in single-best answer exams.

PubMed

Kilgour, James M; Tayyaba, Saadia

2016-08-01

In UK medical schools, five-option single-best answer (SBA) questions are the most widely accepted format of summative knowledge assessment. However, writing SBA questions with four effective incorrect options is difficult and time consuming, and consequently, many SBAs contain a high frequency of implausible distractors. Previous research has suggested that fewer than five-options could hence be used for assessment, without deterioration in quality. Despite an existing body of empirical research in this area however, evidence from undergraduate medical education is sparse. The study investigated the frequency of non-functioning distractors in a sample of 480 summative SBA questions at Cardiff University. Distractor functionality was analysed, and then various question models were tested to investigate the impact of reducing the number of distractors per question on examination difficulty, reliability, discrimination and pass rates. A survey questionnaire was additionally administered to 108 students (33 % response rate) to gain insight into their perceptions of these models. The simulation of various exam models revealed that, for four and three-option SBA models, pass rates, reliability, and mean item discrimination remained relatively constant. The average percentage mark however consistently increased by 1-3 % with the four and three-option models, respectively. The questionnaire survey revealed that the student body had mixed views towards the proposed format change. This study is one of the first to comprehensively investigate distractor performance in SBA examinations in undergraduate medical education. It provides evidence to suggest that using three-option SBA questions would maximise efficiency whilst maintaining, or possibly improving, psychometric quality, through allowing a greater number of questions per exam paper.

Genes2WordCloud: a quick way to identify biological themes from gene lists and free text.

PubMed

Baroukh, Caroline; Jenkins, Sherry L; Dannenfelser, Ruth; Ma'ayan, Avi

2011-10-13

Word-clouds recently emerged on the web as a solution for quickly summarizing text by maximizing the display of most relevant terms about a specific topic in the minimum amount of space. As biologists are faced with the daunting amount of new research data commonly presented in textual formats, word-clouds can be used to summarize and represent biological and/or biomedical content for various applications. Genes2WordCloud is a web application that enables users to quickly identify biological themes from gene lists and research relevant text by constructing and displaying word-clouds. It provides users with several different options and ideas for the sources that can be used to generate a word-cloud. Different options for rendering and coloring the word-clouds give users the flexibility to quickly generate customized word-clouds of their choice. Genes2WordCloud is a word-cloud generator and a word-cloud viewer that is based on WordCram implemented using Java, Processing, AJAX, mySQL, and PHP. Text is fetched from several sources and then processed to extract the most relevant terms with their computed weights based on word frequencies. Genes2WordCloud is freely available for use online; it is open source software and is available for installation on any web-site along with supporting documentation at http://www.maayanlab.net/G2W. Genes2WordCloud provides a useful way to summarize and visualize large amounts of textual biological data or to find biological themes from several different sources. The open source availability of the software enables users to implement customized word-clouds on their own web-sites and desktop applications.

Genes2WordCloud: a quick way to identify biological themes from gene lists and free text

PubMed Central

2011-01-01

Background Word-clouds recently emerged on the web as a solution for quickly summarizing text by maximizing the display of most relevant terms about a specific topic in the minimum amount of space. As biologists are faced with the daunting amount of new research data commonly presented in textual formats, word-clouds can be used to summarize and represent biological and/or biomedical content for various applications. Results Genes2WordCloud is a web application that enables users to quickly identify biological themes from gene lists and research relevant text by constructing and displaying word-clouds. It provides users with several different options and ideas for the sources that can be used to generate a word-cloud. Different options for rendering and coloring the word-clouds give users the flexibility to quickly generate customized word-clouds of their choice. Methods Genes2WordCloud is a word-cloud generator and a word-cloud viewer that is based on WordCram implemented using Java, Processing, AJAX, mySQL, and PHP. Text is fetched from several sources and then processed to extract the most relevant terms with their computed weights based on word frequencies. Genes2WordCloud is freely available for use online; it is open source software and is available for installation on any web-site along with supporting documentation at http://www.maayanlab.net/G2W. Conclusions Genes2WordCloud provides a useful way to summarize and visualize large amounts of textual biological data or to find biological themes from several different sources. The open source availability of the software enables users to implement customized word-clouds on their own web-sites and desktop applications. PMID:21995939

Human Mars Mission: SEP Architecture Crew Taxi Propulsion Stage Study and Design and Technology for Reaction and Control System. Part 1

NASA Technical Reports Server (NTRS)

Young, Archie

1999-01-01

The Mars exploration is a candidate pathway to expand human presence and useful activities in the solar system. There are several propulsion system options being considered to place the Mars payload on its inter-planetary transfer trajectory. One propulsion option is the use of Solar Electric Propulsion (SEP) to spiral out with the Mars payload from an initial Low Earth Orbit (LEO) to an elliptical High Earth Orbit (HEO). This report, presented in annotated facing page format, describes the work completed on the design of a crew taxi propulsion stage used in conjunction with the SEP. Transportation system/mission analysis topics covered in this report include sub-system analysis, trajectory profile description, mass performance and crew taxi stage sizing, stage configuration, stage cost, and Trans-Mars Injection (TMI) launch window. The high efficiency of SEP is used to provide the major part of the TMI propulsion maneuver. Orbital energy is continuously added over a period of approximately twelve months. The SEP and Mars payload follow a spiral trajectory from an initial LEO to a final elliptical HEO. A small chemical stage is then used to provide the final part of the TMI. The now unloaded SEP returns to LEO to repeat another spiral trajectory with payload to HEO. The spiral phase of the SEP's trajectory takes several months to reach HEO, thus significantly increasing the exposure time of the crew to zero-gravity. In order to minimize the long zero-gravity effects, a high thrust chemical stage delivers the crew to the SEP's HEO. The crew rendezvous with the Mars payload in HEO. After a checkout period the Mars payload with the crew is injected onto a Trans-Mars Trajectory by a small chemical stage.

Human Mars Mission: SEP Architecture, Crew Taxi Propulsion Stage Study and Design and Technology for Reaction and Control System. Pt. 1

NASA Technical Reports Server (NTRS)

Young, Archie

1999-01-01

The Mars exploration is a candidate pathway to expand human presence and useful activities in the solar system. There are several propulsion system options being considered to place the Mars payload on its interplanetary transfer trajectory. One propulsion option is the use of Solar Electric Propulsion (SEP) to spiral out with the Mars payload from an initial Low Earth Orbit (LEO) to an elliptical High Earth Orbit (HEO). This report, presented in annotated facing page format, describes the work completed on the design of a crew taxi propulsion stage used in conjunction with the SEP. Transportation system/mission analysis topics covered in this report include sub-system analysis, trajectory profile description, mass performance and crew taxi stage sizing, stage configuration, stage cost, and Trans-Mars Injection (TMI) launch window. The high efficiency of SEP is used to provide the major part of the TMI propulsion maneuver. Orbital energy is continuously added over a period of approximately twelve months. The SEP and Mars payload follow a spiral trajectory from an initial LEO to a final elliptical HEO. A small chemical stage is then used to provide the final part of the TMI. The now unloaded SEP returns to LEO to repeat another spiral trajectory with payload to HEO. The spiral phase of the SEP's trajectory takes several months to reach HEO, thus significantly increasing the exposure time of the crew to zero-gravity. In order to minimize the long zero-gravity effects, a high thrust chemical stage delivers the crew to the SEP's HEO. The crew rendezvous with the Mars payload in HEO. After a checkout period the Mars payload with the crew is injected onto a Trans-Mars Trajectory by a small chemical stage.

Why Parents Choose: Examining Factors Influencing Urban-Suburban Parents to Participate in Schools-within-Schools Programs of Choice

ERIC Educational Resources Information Center

Berry, Pamela N.

2017-01-01

During an era of a strong movement toward national school choice and the much-debated topic of school vouchers, it is critical for today's public school leaders to understand why families make the decision to leave their neighborhood schools and enroll in other school choice options. This study situated school choice within the context of an…

Probing the Natural World, Level III, Teacher's Edition: Well-Being. Intermediate Science Curriculum Study.

ERIC Educational Resources Information Center

Bonar, John R., Ed.; Hathway, James A., Ed.

This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on hazards to the body from drug use. Activities are given that relate to the topic. Optional excursions are suggested for students who wish to study an area in greater depth. An…

Basic Machines - The "Nuts and Bolts" of Technical Physics Minicourse, Career Oriented Pre-Technical Physics. Preliminary Edition.

ERIC Educational Resources Information Center

Bullock, Bob; And Others

This minicourse was prepared for use with secondary physics students in the Dallas Independent School District and is one option in a physics program which provides for the selection of topics on the basis of student career needs and interests. This minicourse was aimed at two levels in the study of basic machines. The "light" level…

Cancer in the Family: Review of the Psychosocial Perspectives of Patients and Family Members

ERIC Educational Resources Information Center

Mitschke, Diane B.

2008-01-01

As advances in cancer care have led to more treatment options and longer survival for cancer patients, a focus on quality of life for patients and their families has gained importance. This review provides a discussion of stress and coping theory, documents the relevance of this topic area for social work practice, and illuminates the results of a…

Depigmentation therapy in vitiligo universalis with cryotherapy and 4-hydroxyanisole.

PubMed

Di Nuzzo, S; Masotti, A

2010-03-01

Vitiligo is a disease characterized by the loss of melanocytes, resulting in progressive depigmentation of skin, and areas of normally pigmented skin can be of cosmetic concern. Several options have been tried to remove the pigment and make the skin a more even colour. We present an easy and effective therapeutic procedure based on single-session cryotherapy followed by topical 4-hydroxyanisole (4-HA).

Economic modeling of effects of climate change on the forest sector and mitigation options: a compendium of briefing papers

Treesearch

Ralph J. Alig

2010-01-01

This report is a compilation of six briefing papers based on literature reviews and syntheses, prepared for U.S. Department of Agriculture, Forest Service policy analysts and decisionmakers about specific questions pertaining to climate change. The main topics addressed here are economic effects on the forest sector at the national and global scales, costs of forest...

Optimizing Crisis Action Planning in the Noncombatant Evacuation Operation Setting

DTIC Science & Technology

2010-06-01

Federal Regulations, the DoS has a firm rule to not enter into preemptive contracts for any logistical resources (e.g., transportation, food, water...bottlenecks, flow limiters, and options to quicken queues ; and identifying resources and transportation mediums that display the most sensitivity to...policy changes. These objectives were addressed by exploring topics in NEOs, evacuation planning, queueing systems, and modeling techniques and

Liposomal lidocaine gel for topical use at the oral mucosa: characterization, in vitro assays and in vivo anesthetic efficacy in humans.

PubMed

Franz-Montan, Michelle; Baroni, Daniela; Brunetto, Giovana; Sobral, Viviane Roberta Vieira; da Silva, Camila Morais Gonçalves; Venâncio, Paulo; Zago, Patricia Wiziack; Cereda, Cintia Maria Saia; Volpato, Maria Cristina; de Araújo, Daniele Ribeiro; de Paula, Eneida; Groppo, Francisco Carlos

2015-03-01

To characterize liposomal-lidocaine formulations for topical use on oral mucosa and to compare their in vitro permeation and in vivo anesthetic efficacy with commercially available lidocaine formulations. Large unilamellar liposomes (400 nm) containing lidocaine were prepared using phosphatidylcholine, cholesterol, and α-tocoferol (4:3:0.07, w:w:w) and were characterized in terms of membrane/water partition coefficient, encapsulation efficiency, size, polydispersity, zeta potential, and in vitro release. In vitro permeation across pig palatal mucosa and in vivo topical anesthetic efficacy on the palatal mucosa in healthy volunteers (double-blinded cross-over, placebo controlled study) were performed. The following formulations were tested: liposome-encapsulated 5% lidocaine (Liposome-Lido5); liposome-encapsulated 2.5% lidocaine (Liposome-Lido2.5); 5% lidocaine ointment (Xylocaina®), and eutectic mixture of lidocaine and prilocaine 2.5% (EMLA®). The Liposome-Lido5 and EMLA showed the best in vitro permeation parameters (flux and permeability coefficient) in comparison with Xylocaina and placebo groups, as well as the best in vivo topical anesthetic efficacy. We successfully developed and characterized a liposome encapsulated 5% lidocaine gel. It could be considered an option to other topical anesthetic agents for oral mucosa.

Rainy Weather Science.

ERIC Educational Resources Information Center

Reynolds, Karen

1996-01-01

Presents ideas on the use of rainy weather for activities in the earth, life, and physical sciences. Topics include formation and collision of raindrops, amount and distribution of rain, shedding of water by plants, mapping puddles and potholes, rainbow formation, stalking storms online, lightning, and comparing particles in the air before and…

Preparatory studies of zero-g cloud drop coalescence experiment

NASA Technical Reports Server (NTRS)

Telford, J. W.; Keck, T. S.

1979-01-01

Experiments to be performed in a weightless environment in order to study collision and coalescence processes of cloud droplets are described. Rain formation in warm clouds, formation of larger cloud drops, ice and water collision processes, and precipitation in supercooled clouds are among the topics covered.

Mapping regulatory models for medicinal cannabis: a matrix of options.

PubMed

Belackova, Vendula; Shanahan, Marian; Ritter, Alison

2017-05-30

Objective The aim of the present study was to develop a framework for assessing regulatory options for medicinal cannabis in Australia. Methods International regulatory regimes for medicinal cannabis were reviewed with a qualitative policy analysis approach and key policy features were synthesised, leading to a conceptual framework that facilitates decision making across multiple dimensions. Results Two central organising dimensions of medicinal cannabis regulation were identified: cannabis supply and patient authorisation (including patient access). A number of the different supply options can be matched with a number of different patient authorisation options, leading to a matrix of possible regulatory regimes. Conclusions The regulatory options, as used internationally, involve different forms of cannabis (synthetic and plant-based pharmaceutical preparations or herbal cannabis) and the varying extent to which patient authorisation policies and procedures are stringently or more loosely defined. The optimal combination of supply and patient authorisation options in any jurisdiction that chooses to make medicinal cannabis accessible will depend on policy goals. What is known about the topic? Internationally, regulation of medicinal cannabis has developed idiosyncratically, depending on formulations that were made available and local context. There has been no attempt to date in the scientific literature to systematically document the variety of regulatory possibilities for medicinal cannabis. What does this paper add? This paper presents a new conceptual schema for considering options for the regulation of medicinal cannabis, across both supply and patient authorisation aspects. What are the implications for practitioners? The design of regulatory systems in Australia, whether for pharmaceutical or herbal products, is a vital issue for policy makers right now as federal and state and territory governments grapple with the complexities of medicinal cannabis regulation. The conceptual schema presented herein provides a tool for more systematic thinking about the options.

Interprofessional peer-assisted learning as a low-threshold course for joint learning: Evaluation results of the interTUT Project.

PubMed

Reichel, Kathrin; Dietsche, Stefan; Hölzer, Henrike; Ewers, Michael

2016-01-01

The delivery of needs-based health care services requires a team-based and collaborative approach of different health professionals, which is not yet sufficienctliy implemented on a day to day basis. Interprofessional learning activities aim to respond to this in future. The cross-university pilot project interTUT used peer-assisted learning approaches and extracurricular tutorials in order address this issue. During the pilot phase, eight students and trainees have been acquired. Together, they prepared and led four extracurricular tutorials on core topics of interprofessional cooperation and documented them in procedure manuals. The course was evaluated using a standardized participant survey (n=72) and two focus groups (n=3, n=5) in which participants were asked to reflect on their individual learning experiences. Descriptive statistics were used to analyze the survey data and the focus group material was interpreted using qualitative content analysis. The results indicated a high level of satisfaction, acceptance of and further demand for peer-supported learning activities. The students and trainees reported changed attitudes and subjective knowledge growth regarding the other professional groups. The constructive learning atmosphere as well as having access to a forum for interprofessional exchange were equally valued. Extracurricular tutorials offer a low-threshold and very promising point of contact for the facilitation of interprofessional teaching and learning. However, this should be viewed against the background that, as part of the pilot project, only a small number of students and trainees who were already interested in the topic could be reached by this optional course. A comprehensive, long-term trial of this teaching and learning format, its linkage to curricular courses, and further research on its education-specific and practice-related effects are, therefore, necessary.

Interprofessional peer-assisted learning as a low-threshold course for joint learning: Evaluation results of the interTUT Project

PubMed Central

Reichel, Kathrin; Dietsche, Stefan; Hölzer, Henrike; Ewers, Michael

2016-01-01

Background and objective: The delivery of needs-based health care services requires a team-based and collaborative approach of different health professionals, which is not yet sufficienctliy implemented on a day to day basis. Interprofessional learning activities aim to respond to this in future. The cross-university pilot project interTUT used peer-assisted learning approaches and extracurricular tutorials in order address this issue. Methodology: During the pilot phase, eight students and trainees have been acquired. Together, they prepared and led four extracurricular tutorials on core topics of interprofessional cooperation and documented them in procedure manuals. The course was evaluated using a standardized participant survey (n=72) and two focus groups (n=3, n=5) in which participants were asked to reflect on their individual learning experiences. Descriptive statistics were used to analyze the survey data and the focus group material was interpreted using qualitative content analysis. Results: The results indicated a high level of satisfaction, acceptance of and further demand for peer-supported learning activities. The students and trainees reported changed attitudes and subjective knowledge growth regarding the other professional groups. The constructive learning atmosphere as well as having access to a forum for interprofessional exchange were equally valued. Conclusions: Extracurricular tutorials offer a low-threshold and very promising point of contact for the facilitation of interprofessional teaching and learning. However, this should be viewed against the background that, as part of the pilot project, only a small number of students and trainees who were already interested in the topic could be reached by this optional course. A comprehensive, long-term trial of this teaching and learning format, its linkage to curricular courses, and further research on its education-specific and practice-related effects are, therefore, necessary. PMID:27280141

Military Space Doctrine: the Great Frontier.

DTIC Science & Technology

1981-04-03

Hall 0745 Conference Registration Fairchild Hall H-1 (Continental breakfast served in conference area included in registration fee 0810 Movie : (optional...roundtable sign-ups 1200 Cadet Lunch Formation Review Eagle and Fledglings 1220 Lunch with Cadet Wing Mitchell Hall (cost collected at registration...Continental breakfast at conference area (included in the registration fee) 0755 Movie : (optional) Space - The New Ocean Fairchild Hall H-i 0800 Opening

Earth land landing alternatives: Lunar transportation system

NASA Technical Reports Server (NTRS)

Meyerson, Robert

1992-01-01

The objectives of this study are as follows: (1) develop a landing option such that it is a viable trade option for future NASA missions; (2) provide NASA programs with solid technical support in the landing systems area; (3) develop the technical staff; and (4) advance the state of landing systems technology to apply to future NASA missions. All results are presented in viewgraph format.

The two sides of the coin: Similarities and differences in the pathomechanisms of fistulas and stricture formations in irritable bowel disease.

PubMed

Scharl, Michael; Bruckner, Ramona S; Rogler, Gerhard

2016-08-01

Fistulas and fibrosis or strictures represent frequent complications in irritable bowel disease (IBD) patients. To date, treatment options for fistulas are limited and surgery is often required. Similarly, no preventive treatment for fibrosis and stricture formation has been established. Frequently, stricture formation and fibrosis precede fistula formation, indicating that both processes may be connected or interrelated. Knowledge about the pathology of both processes is limited. A crucial role for the epithelial-to-mesenchymal transition (EMT) in fistula development has been demonstrated. Of note, EMT also plays a major role in the pathogenesis of fibrosis in many organs, and most likely also plays that role in the intestine. In addition, aberrant matrix remodeling, as well as soluble factors such as tumor necrosis factor (TNF), interleukin 13 (IL-13) and tumor growth factor beta (TGFβ) were involved, both in the onset of the fistula and fibrosis formation. Both fistulas and fibrosis may occur due to deregulated wound healing mechanisms from chronic and severe intestinal inflammation; however, further research is required to obtain a better understanding of the complex pathophysiology of fistula and intestinal fibrosis formation, to allow the development of new and more effective preventive treatment options for those important disease complications.

The Flipped Classroom: A Modality for Mixed Asynchronous and Synchronous Learning in a Residency Program

PubMed Central

Young, Timothy P.; Bailey, Caleb J.; Guptill, Mindi; Thorp, Andrea W.; Thomas, Tamara L.

2014-01-01

Introduction A “flipped classroom” educational model exchanges the traditional format of a classroom lecture and homework problem set. We piloted two flipped classroom sessions in our emergency medicine (EM) residency didactic schedule. We aimed to learn about resident and faculty impressions of the sessions, in order to develop them as a regular component of our residency curriculum. Methods We evaluated residents’ impression of the asynchronous video component and synchronous classroom component using four Likert items. We used open-ended questions to inquire about resident and faculty impressions of the advantages and disadvantages of the format. Results For the Likert items evaluating the video lectures, 33/35 residents (94%, 95% CI 80%–99%) responded that the video lecture added to their knowledge about the topic, and 33/35 residents felt that watching the video was a valuable use of their time. For items evaluating the flipped classroom format, 36/38 residents (95%, 95% CI 82%–99%) preferred the format to a traditional lecture on the topic, and 38/38 residents (100%, 95% CI 89%–100%) felt that the small group session was effective in helping them learn about the topic. Most residents preferred to see the format monthly in our curriculum and chose an ideal group size of 5.5 (first session) and 7 (second session). Residents cited the interactivity of the sessions and access to experts as advantages of the format. Faculty felt the ability to assess residents’ understanding of concepts and provide feedback were advantages. Conclusion Our flipped classroom model was positively received by EM residents. Residents preferred a small group size and favored frequent use of the format in our curriculum. The flipped classroom represents one modality that programs may use to incorporate a mixture of asynchronous and interactive synchronous learning and provide additional opportunities to evaluate residents. PMID:25493157

Striae and Their Relation to Topical Steroid Therapy

PubMed Central

Adam, J. E.; Craig, Gibson

1965-01-01

Atrophic striae have been reported to occur normally in 35% of adolescents and abnormally in a variety of medical conditions. Recently, the occurrence of striae has been observed in adults after the use of potent topical steroids with occlusion. Pre-existing striae have been found to enlarge after topical steroid therapy, even without occlusion. The mechanism of striae formation appears to be due to the action of the steroids on the dermal connective tissue and/or dermal matrix rather than to mechanical tension. ImagesFig. 1Fig. 2 PMID:14270214

Granulomatous Inflammation of the Penis and Scrotum Following Application of Topical Cream.

PubMed

Khan, Amir Ishaq; Mehta, Akanksha; Sekhar, Aarti; Ellis, Carla L

2017-05-01

Granulomas are collections of histiocytes that develop as an inflammatory response to bacterial and fungal infections, as well as foreign substances. We discuss here the case of a 49-year-old male who presented with a penile and scrotal mass with granulomatous inflammation, after application of a topical cream for enhancement of erectile function. While granuloma formation can often be seen with penile injections, this case presents the rare development of a foreign body granuloma after topical cream application on the penis and scrotum.

Connective Tissue Nevi: A Review of the Literature.

PubMed

Arora, Harleen; Falto-Aizpurua, Leyre; Cortés-Fernandez, Andrea; Choudhary, Sonal; Romanelli, Paolo

2017-05-01

Connective tissue nevi (CTN) are hamartomas of the dermis, with the 3 main components being collagen, elastin, and proteoglycans. Each subtype can present as a solitary lesion or multiple lesions. They could present as part of systemic diseases or inherited disorders. This article provides a comprehensive literature review of the different types of CTN, their clinical presentations, associations, and treatment options. Treatment options for 56 lesions were reviewed. Fifty-two percent of lesions were present in males, and the age range at the time of presentation was wide (1.6-80 years). Management varied according to CTN subtypes. Most lesions (14) received topical or intralesional treatment with corticosteroids, followed by surgical removal of lesions (12), whereas the remaining lesions were clinically monitored.

Systems engineering aspects of a preliminary conceptual design of the space station environmental control and life support system

NASA Technical Reports Server (NTRS)

Lin, C. H.; Meyer, M. S.

1983-01-01

The systems engineering aspects of developing a conceptual design of the Space Station Environmental Control and Life Support System (ECLSS) are discussed. Topics covered include defining system requirements and groundrules for approach, formulating possible cycle closure options, and establishing a system-level mass balance on the essential materials processed in oxygen and water cycles. Consideration is also given to the performance of a system trade-off study to determine the best degree of cycle closure for the ECLSS, and the construction of a conceptual design of the ECLSS with subsystem performance specifications and candidate concepts. For the optimum balance between development costs, technological risks, and resupply penalties, a partially closed cycle ECLSS option is suggested.

Students' Conceptions of Glaciers and Ice Ages: Applying the Model of Educational Reconstruction to Improve Learning

ERIC Educational Resources Information Center

Felzmann, Dirk

2017-01-01

Glaciers and ice ages are important topics in teaching geomorphology, earth history, and climate change. As with many geoscience topics, glacier formation, glacier movement, glacial morphology, and ice ages consist of a wide variety of processes and phenomena. Accordingly, it must be decided which of those processes and phenomena should be part of…

A Survey of Beginning Crop Science Courses at 49 U.S. Universities. I. Lecture Format, Teaching Methods, and Topical Content.

ERIC Educational Resources Information Center

Karnok, Keith J.; Connors, Krista L.

1986-01-01

This paper is the first of a two-part series which discusses the findings related to lecture information in beginning crop science courses offered in Land Grant institutions. Survey results revealed considerable differences regarding course organization and teaching methods, but similarities in overall goals and topic areas. (ML)

Second Language Reading Topic Familiarity and Test Score: Test-Taking Strategies for Multiple-Choice Comprehension Questions

ERIC Educational Resources Information Center

Lee, Jia-Ying

2011-01-01

The main purpose of this study was to compare the strategies used by Chinese-speaking students when confronted with familiar versus unfamiliar topics in a multiple-choice format reading comprehension test. The focus was on describing what students do when they are taking reading comprehension tests by asking students to verbalize their thoughts.…

Incorporating environmental concerns into power sector decision-making: A case study of Sri Lanka. World Bank Environment Paper 6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meier, P.; Munasinghe, M.; Team, S.L.S.

1994-04-01

Weighs Sri Lanka`s options for addressing environmental concerns during the planning stages of energy policymaking. Here is a holistic approach to analyzing the environmental impact of various power systems. Unlike standard impact studies that begin at the project level, this method calls for environmental assessments that start at the planning stage of a national framework for energy policymaking. The framework would take into account the energy needs of Sri Lanka`s total economy. It also would make it easier to incorporate environmental goals into power sector decisionmaking at the critical investment stage. Sri Lanka`s development options for the power sector aremore » reviewed in detail. Topics include alternative ways to assess the economic value of a power plant`s impact on biodiversity, human health, and air and water pollution. The study also assesses which energy planning options work best and recommends ways in which the Ceylon Electricity Board can improve its environmental policies.« less

The Concept of a Single-sex Optional Discussion Session in Introductory Astronomy at a Publicly Funded University

NASA Astrophysics Data System (ADS)

Shawl, S.

1996-12-01

The concept of single-sex education for science and mathematics has recently received renewed discussion in both the popular and professional literature. So important is the topic within higher education that the Duke Journal of Gender Law and Policy sponsored a symposium called "Gender & The Higher Education Classroom: Maximizing the Learning Environment" in February 1996 (http://www.duke.edu/ jrd4/djgcnf96.htm). The concept is especially controversial in publicly supported educational institutions. The idea of offering an optional discussion session limited to a single sex in a university-level introductory astronomy course at a State-supported school was considered through discussions with a number of faculty and administrators, and through a questionnaire aimed at determining student attitudes toward the concept. The results of the student questionnaire will be presented. (While the questionnaire results will be seen to be in favor of such an optional discussion session, such sessions have not been offered.)

libvaxdata: VAX data format conversion routines

USGS Publications Warehouse

Baker, Lawrence M.

2005-01-01

libvaxdata provides a collection of routines for converting numeric data-integer and floating-point-to and from the formats used on a Digital Equipment Corporation1 (DEC) VAX 32-bit minicomputer (Brunner, 1991). Since the VAX numeric data formats are inherited from those used on a DEC PDP-11 16-bit minicomputer, these routines can be used to convert PDP-11 data as well. VAX numeric data formats are also the default data formats used on DEC Alpha 64-bit minicomputers running OpenVMS The libvaxdata routines are callable from Fortran or C. They require that the caller use two's-complement format for integer data and IEEE 754 format (ANSI/IEEE, 1985) for floating-point data. They also require that the 'natural' size of a C int type (integer) is 32 bits. That is the case for most modern 32-bit and 64-bit computer systems. Nevertheless, you may wish to consult the Fortran or C compiler documentation on your system to be sure. Some Fortran compilers support conversion of VAX numeric data on-the-fly when reading or writing unformatted files, either as a compiler option or a run-time I/O option. This feature may be easier to use than the libvaxdata routines. Consult the Fortran compiler documentation on your system to determine if this alternative is available to you. 1Later Compaq Computer Corporation, now Hewlett-Packard Company

Special Section: The USMARC Community Information Format.

ERIC Educational Resources Information Center

Lutz, Marilyn; And Others

1992-01-01

Five papers discuss topics related to the USMARC Community Information Format (CIF), including using CIF to create a public service resource network; development of a CIF-based database of materials relating to multicultural and differently-abled populations; background on CIF; development of an information and referral database; and CIF and…

Learning, Family Formation and Dissolution. Wider Benefits of Learning Research Report.

ERIC Educational Resources Information Center

Blackwell, Louisa; Bynner, John

The relationship between learning and family formation and dissolution was examined through a review of the literature that focused on education and family life in Great Britain and elsewhere. The following topics were examined: learning, marriage, and cohabitation; learning, dissolution, and divorce; changing patterns of childbearing in…

Genetic Engineering--A Lesson on Bioethics for the Classroom.

ERIC Educational Resources Information Center

Armstrong, Kerri; Weber, Kurt

1991-01-01

A unit designed to cover the topic of genetic engineering and its ethical considerations is presented. Students are expected to learn the material while using a debate format. A list of objectives for the unit, the debate format, and the results from an opinion questionnaire are described. (KR)

Glycosidation of Methanol with Ribose: An Interdisciplinary Undergraduate Laboratory Experiment

ERIC Educational Resources Information Center

Simon, Erin; Cook, Katie; Pritchard, Meredith R.; Stripe, Wayne; Bruch, Martha; Bendinskas, Kestutis

2010-01-01

This exercise provides students hands-on experience with the topics of glycosidation, hemiacetal and acetal formation, proton nuclear magnetic resonance ([superscript 1]H NMR) spectroscopy, and kinetic and thermodynamic product formation. In this laboratory experiment, the methyl acetal of ribose is synthesized, and the kinetic and thermodynamic…

Formative Assessment in Primary Science

ERIC Educational Resources Information Center

Loughland, Tony; Kilpatrick, Laetitia

2015-01-01

This action learning study in a year three classroom explored the implementation of five formative assessment principles to assist students' understandings of the scientific topic of liquids and solids. These principles were employed to give students a greater opportunity to express their understanding of the concepts. The study found that the…

Des Machines pour ecrire (Writing Machines).

ERIC Educational Resources Information Center

Mirande, Corinne

1996-01-01

A variety of formats for writing news articles and announcements on a variety of common topics (current events, cultural events, sports, surveys, interviews, travelogs, and classified advertising) is presented in fill-in-the-blank form. Suggestions are offered for using these formats to teach French usage at all levels. (MSE)

Formation in the Classroom

ERIC Educational Resources Information Center

Glennon, Fred; Jacobsen, Douglas; Jacobsen, Rhonda Hustedt; Thatamanil, John J.; Porterfield, Amanda; Moore, Mary Elizabeth

2011-01-01

What is the relationship between the academic knowledge of the guild and the formation of students in the classroom? This Forum gathers four essays originally presented at a Special Topics Session at the 2009 conference of the American Academy of Religion (Atlanta, Georgia), with a brief introductory essay by Fred Glennon explaining the genesis of…

Therapeutic Options in Idiopathic Burning Mouth Syndrome: Literature Review

PubMed Central

Miziara, Ivan; Chagury, Azis; Vargas, Camila; Freitas, Ludmila; Mahmoud, Ali

2014-01-01

Introduction Burning mouth syndrome (BMS) is characterized by a burning sensation in the tongue, palate, lips, or gums of no well-defined etiology. The diagnosis and treatment for primary BMS are controversial. No specific laboratory tests or diagnostic criteria are well established, and the diagnosis is made by excluding all other possible disorders. Objective To review the literature on the main treatment options in idiopathic BMS and compare the best results of the main studies in 15 years. Data Synthesis We conducted a literature review on PubMed/MEDLINE, SciELO, and Cochrane-BIREME of work in the past 15 years, and only selected studies comparing different therapeutic options in idiopathic BMS, with preference for randomized and double-blind controlled studies. Final Comments Topical clonazepam showed good short-term results for the relief of pain, although this was not presented as a definitive cure. Similarly, α-lipoic acid showed good results, but there are few randomized controlled studies that showed the long-term results and complete remission of symptoms. On the other hand, cognitive therapy is reported as a good and lasting therapeutic option with the advantage of not having side effects, and it can be combined with pharmacologic therapy. PMID:25992157

LOGSIM user's manual. [Logic Simulation Program for computer aided design of logic circuits

NASA Technical Reports Server (NTRS)

Mitchell, C. L.; Taylor, J. F.

1972-01-01

The user's manual for the LOGSIM Program is presented. All program options are explained and a detailed definition of the format of each input card is given. LOGSIM Program operations, and the preparation of LOGSIM input data are discused along with data card formats, postprocessor data cards, and output interpretation.

Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy: A Randomized, Controlled Trial

PubMed Central

Salale, Nesrin; Treldal, Charlotte; Mogensen, Stine; Rasmussen, Mette; Petersen, Janne; Andersen, Ove; Jacobsen, Jette

2014-01-01

Unsedated upper gastrointestinal endoscopy (UGE) can induce patient discomfort, mainly due to a strong gag reflex. The aim was to assess the effect of a bupivacaine lozenge as topical pharyngeal anesthetic compared with standard treatment with a lidocaine spray before UGE. Ninety-nine adult outpatients undergoing unsedated diagnostic UGE were randomized to receive either a bupivacaine lozenge (L-group, n = 51) or lidocaine spray (S-group, n = 42). Primary objective was assessment of patient discomfort including acceptance of the gag reflex during UGE. The L-group assessed the discomfort significantly lower on a visual analog scale compared with the S-group (P = 0.02). There was also a significant difference in the four-point scale assessment of the gag reflex (P = 0.03). It was evaluated as acceptable by 49% in the L-group compared with 31% in the S-group. A bupivacaine lozenge compared with a lidocaine spray proved to be a superior option as topical pharyngeal anesthetic before an UGE. PMID:25374463

[Atopic dermatitis and urticaria: for the prevention and cure via disease control and management].

PubMed

Furukawa, Fukumi

2009-11-01

Standard ways of management are introduced through guidelines. The present standard therapies for atopic dermatitis consist of the use of topical steroids and tacrolimus ointment for inflammation as well as emollients for dry and barrier-disrupted skin as the first-line topical application, systemic anti-histamines and anti-allergic drugs for pruritus, avoidance of apparent exacerbating factors and so on. The importance of correct selection of topical steroids according to the severity of the lesion is also emphasized. As for urticaria, the use of oral histamine H1-receptor antagonists is the first line treatment, regardless of the groups, provided that sufficient efforts to eliminate the cause and/or aggravating factors are taken. Several options for the treatment are suggested as the second and/or the third line treatments, but the aim of examinations and treatments should be determined according to the type and severity of the diseases. Standard therapies and elimination of the cause and/or aggravating factors are the best way for the cure and prevention.

Topical Nitroglycerine for Neonatal Arterial Associated Peripheral Ischemia following Cannulation: A Case Report and Comprehensive Literature Review

PubMed Central

Mosalli, Rafat; Elbaz, Mohamed; Paes, Bosco

2013-01-01

Arterial cannulation in neonates is usually performed for frequent blood pressure monitoring and blood sampling. The procedure, while easily executed by skilled neonatal staff, can be associated with serious complications such as vasospasm, thrombosis, embolism, hematoma, infection, peripheral nerve damage, ischemia, and tissue necrosis. Several treatment options are available to reverse vascular induced ischemia and tissue damage. Applied interventions depend on the extent of tissue involvement and whether the condition is progressive and deemed life threatening. Standard, noninvasive measures include immediate catheter removal, limb elevation, and warming the contralateral extremity. Topical vasodilators, anticoagulation, thrombolysis, and surgery are considered secondary therapeutic strategies. A comprehensive literature search indicates that topical nitroglycerin has been utilized for the treatment of tissue ischemia in three preterms with umbilical arterial catheters and four with peripheral arterial lines. We report the first successful use of nitroglycerine ointment in a critically ill preterm infant with ischemic hand changes after brachial artery cannulation. PMID:24251058

Management of a severe thoracoabdominal injury from motorized sawing machine in a temporary semi-urban university teaching hospital: a case report.

PubMed

Fente, B G; Nwagwu, C C; Ogulu, B N; Orukari, G I B; Okere, E O; Miss Ouserigha, O E

2012-01-01

Report of our experience and outcome of a case of severe thoracoabdominal injuries by motorized sawing machine (a rare cause) in a Semi-Urban temporary University Teaching Hospital. Literature review on the topic was done using Pubmed. Relevant journals and topics were also reviewed. Textbooks on relevant topics were also searched. A 25 year old male timber-cutter was traumatized by motorized sawing machine injuring the left half of the chest, upper abdomen, the left shoulder and left hand. It is an unusual presentation of penetrating thoracoabdominal injury. There was open pneumotharax, 3th-8th ribs fractures, diaphragmatic laceration, and eviscerations of abdominal contents without affecting other thoraco-abdominal organs. Urgent surgical intervention done was the only option. The challenges posed by severe motorized sawing machine thoraco-abdominal injuries in a Semi-Urban temporary University Teaching Hospital were successfully managed due to rapid pre-hospital transfer and co-ordinated team effort.

Effects of topical oxygen therapy on ischemic wound healing.

PubMed

Rao, Congqiang; Xiao, Liling; Liu, Hongwei; Li, Shenghong; Lu, Jinqiang; Li, Jiangxuan; Gu, Shixing

2016-01-01

[Purpose] This study evaluated the effects of topical oxygen therapy on the hind limb wounds of rats under ischemic conditions. [Subjects and Methods] Twelve injured rats were treated with topical oxygen on skin wounds located on the hind limb and compared with twelve injured control rats. Indexes including gross morphology of the wound, wound healing time, wound healing rate, and histological and immunohistochemical staining of sections of wound tissue were examined at different time points after intervention. [Results] The wound healing time was shorter in the topical oxygen therapy group than the control group. The wound healing rate and granulation tissue formation in the topical oxygen therapy group showed significant improvement on days 3, 7, and 14. Through van Gieson staining, the accumulation of collagen fiber in the topical oxygen therapy group was found to have improved when compared with the control group on day 7. Through semiquantitative immunohistochemical staining, many more new vessels were found in the topical oxygen therapy group compared with the model control group on day 7. [Conclusion] The results of the experiment showed that topical oxygen therapy improved ischemic wound healing.

The effects of topical agent (kelo-cote or contractubex) massage on the thickness of post-burn scar tissue formed in rats.

PubMed

Ko, Won Jin; Na, Young Cheon; Suh, Bum Sin; Kim, Hyeon A; Heo, Woo Hoe; Choi, Gum Ha; Lee, Seo Ul

2013-11-01

We conducted an experimental study to compare the effect of massage using topical agents (Kelo-cote or Contractubex) on scar formation by massaging the healed burn wound on the dorsal area of Sprague-Dawley (SD) rats. Four areas of second degree contact burn were made on the dorsal area of each of 15 SD rats, using a soldering iron 15 mm in diameter. After gross epithelialization in the defect, 15 SD rats were randomly divided into four groups: the Kelo-cote group, Contractubex group, Vaseline group, and control group. Rats in three of the groups (all but the Control group) were massaged twice per day for 5 minutes each day, while those in the Control group were left unattended. For histologic analysis, we performed a biopsy and evaluated the thickness of scar tissue. In the Kelo-cote and Contractubex groups, scar tissue thicknesses showed a significant decrease, compared with the Vaseline and control groups. However, no significant differences were observed between the Kelo-cote and Contractubex groups. In the Vaseline group, scar tissue thicknesses showed a significant decrease, compared with the control groups. The findings of this study suggest that massage using a topical agent is helpful in the prevention of scar formation and that massage only with lubricant (no use of a topical agent) also has a considerable effect, although not as much as the use of a topical agent. Thus, we recommend massage with a topical agent on the post-burn scar as an effective method for decreasing the scar thickness.

Use of abnormal and health psychology as topics in a classroom format to reduce alcohol and other drug abuse among college students at risk.

PubMed

Miley, W M

2001-12-01

This study was done to assess whether classes containing topics derived from two college courses, Abnormal Psychology and Health Psychology, could be used in a class room format to reduce alcohol and other drug abuse among at-risk college students. Topics covered included stress and stress management, alcohol and other drug use and abuse, chronic illnesses and psychological disorders that develop from an unhealthy lifestyle, and factors that play a role in good health and well-being. Students were enrolled in a semester-long course for college credit as an alternative to punitive sanctions for on-campus alcohol violations and other drug violations. The Midwest Institute on Drug Use Survey and the CORE Alcohol and Drug Survey were administered on the first and last days of class. Analysis indicated a significant self-reported reduction in drug use and associated negative symptoms and behavioral effects. Women were more likely to report reductions in drug use than men.

Safety of available and emerging drug therapies for hyperhidrosis.

PubMed

Hosp, Christine; Hamm, Henning

2017-09-01

Hyperhidrosis affects 4.8% of the U.S. population and has been underestimated by physicians for long time despite considerable interference with quality of life. Many patients suffer from primary (idiopathic) hyperhidrosis which results from over-activity of sympathetic nerves and is restricted to specific body areas, mostly the axillae, palms, soles, or head. Secondary hyperhidrosis is caused by an underlying disease or the intake of medications and often involves large parts of the body. Numerous effective therapies with topical or systemic drugs and surgical options are available. Areas covered: Efficacy and safety data on aluminum salts, anticholinergic drugs for topical or systemic application, and on intradermal botulinum toxin injections used to treat hyperhidrosis are critically evaluated, including data from clinical trials with focus on possible side effects and long-term complications in dispute. Expert opinion: Hyperhidrosis often responds well to available therapies. Depending on the type of hyperhidrosis treatment should be topical/local or systemic. Most of the side effects are mild, transient and easily manageable. In case of systemic treatment with anticholinergics low dosing and up-titration of medication is necessary to avoid severe adverse effects. Concerns about the promotion of breast cancer and Alzheimer disease by topical aluminum salts are unsolved.

Hot asphalt burns: a review of injuries and management options.

PubMed

Bosse, George M; Wadia, Shernaz A; Padmanabhan, Pradeep

2014-07-01

Hot asphalt burns to human tissue can increase the likelihood of infection and potential conversion of partial thickness to full-thickness injuries. Successful intervention for hot asphalt burns requires immediate and effective cooling of the asphalt on the tissue followed by subsequent gradual removal of the cooled asphalt. A review of the literature reveals that multiple substances have been used to remove asphalt, including topical antibiotics, petroleum jelly, a commercial product known as De-Solv-It (ORANGE-SOL, Chandler, AZ), sunflower oil, baby oil, liquid paraffin, butter, mayonnaise, and moist-exposed burn ointment (MEBO). Although many of these products may be effective in the removal of asphalt, they may not be readily available in an emergency department setting. Topical antibiotics are readily available, are more commonly described in the medical literature, and would be expected to be effective in the removal of asphalt. We developed guidelines for on scene (first-aid) management and the initial care of such patients upon presentation to a health care facility. These guidelines emphasize the principles of early cooling, gradual removal of adherent asphalt using topical antibiotics, and avoidance of the use of topical agents, which are likely to result in tissue toxicity.

Mobile phone waste management and recycling: Views and trends.

PubMed

Sarath, P; Bonda, Sateesh; Mohanty, Smita; Nayak, Sanjay K

2015-12-01

There is an enormous growth in mobile phone consumption worldwide which leads to generation of a large volume of mobile phone waste every year. The aim of this review is to give an insight on the articles on mobile phone waste management and recycling, published in scientific journals, major proceedings and books from 1999 to 2015. The major areas of research have been identified and discussed based on available literature in each research topic. It was observed that most of these articles were published during the recent years, with the number of articles increasing yearly. Material recovery and review on management options of waste are found to be the leading topics in this area. Researchers have proved that economically viable refurbishing or recycling of such waste is possible in an environmentally friendly manner. However, the literatures indicate that without proper consumer awareness, a recycling system cannot perform to its maximum efficiency. The methodologies followed and analytical techniques employed by the researchers to attain their objectives have been discussed. The graphical representations of available literature on current topic with respect to year of publication, topics and location have also been explored. Copyright © 2015 Elsevier Ltd. All rights reserved.

Annual Surveillance Summary: Klebsiella Species Infections in the Military Health System (MHS), 2016

DTIC Science & Technology

2017-06-01

sources were linked to assess descriptive and clinical factors related to Klebsiella. Health Level 7 (HL7)-formatted Composite Health Care System (CHCS...and DOD AD populations are increasing. In 2016, the annual Klebsiella species IR increased by 10.8% compared to the weighted historic IR; this...fluoroquinolones present better treatment options compared to nitrofurans based on susceptibility. Nitrofurantoin as a viable treatment option for

Rural Schools Prototype Analysis. Volume II: Methodology. An Example Process of Identifying Determinants, Selecting Options, & Developing Schematic Designs.

ERIC Educational Resources Information Center

Construction Systems Management, Inc., Anchorage, AK.

Volume II of a 3-volume report demonstrates the use of Design Determinants and Options (presented in Volume I) in the planning and design of small rural Alaskan secondary schools. Section I, a checklist for gathering site-specific information to be used as a data base for facility design, is organized in the same format as Volume I, which can be…

Productivity, job satisfaction, and health and safety in the coal industry: the participatory alternative

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1982-01-01

This is a conference which presents results and ideas on workplace participation in the coal industry. It discusses the theory of the quality circle groups for developing their own production rates and design goals. It presents the results of different coal company participation in this idea and how to implement this option. Individual topics are entered into the Data Base as separate items.

The Decline of the Breast: An Examination of Its Impact on Fertility and Health, and Its Relation to Socioeconomic Status. Cornell International Nutrition Monograph Series, Number 10 (1982).

ERIC Educational Resources Information Center

Latham, Michael C., Ed.

The three papers in this collection discuss, respectively, the relationship of breastfeeding to human fertility, strategies to improve feeding of infants and young children, and infant feeding options for Thai professional women residing in Bangkok. Specific topics addressed in the first paper include the physiological role of lactation on…

Changing Dimensions: Managing Library and Information Services for the 1990s: A Global Perspective. Proceedings of the Asian/Pacific American Librarians Association [Conference] (Atlanta, Georgia, July 1, 1991).

ERIC Educational Resources Information Center

Sharma, Ravindra Nath, Ed.

The theme of the 1991 Asian/Pacific American Librarians Association (APALA) was "Changing Dimensions: Managing Library Information Services for the 1990s and Beyond." Members and speakers were invited to discuss this topic from all dimensions of library and information related fields. Presenters had the options either to write on actual…

Homelessness and the Public's Health: Legal Responses.

PubMed

Hodge, James G; DiPietro, Barbara; Horton-Newell, Amy E

2017-03-01

This commentary addresses public health issues underlying homelessness and related law, policy, and advocacy options. After framing public health issues for affected individuals and the community, legal and policy approaches and related barriers are assessed. Major topics include deficits in housing availability, the role of state-based Medicaid programs, criminalization of homelessness, and the use of emergency declarations seeking to address particular issues related to homelessness in select states and localities.

Liquid Rocket Booster (LRB) for the Space Transportation System (STS) Systems Study. Amendment 13: Orientation meeting

NASA Technical Reports Server (NTRS)

1990-01-01

The topics are presented in viewgraph form and include the following: LRB study results summary -- Feb. 1989; LRB study results -- Jan. 1990; Shuttle configuration with booster options; LRB study results -- Sept. 1990; LRB statement of work tasks; ground rules and assumptions; study flow of design, manufacturing/production, and test program/certification; study products; study schedule; and candidate 1.5 stage engine arrangements.

Alternative Education: An Introduction, a Special Report on Pasadena, California, and a Bibliography. Oregon School Study Council Bulletin, Vol. 17, No. 10.

ERIC Educational Resources Information Center

Oregon School Study Council, Eugene.

The rapid increase in the number of alternative schools in the past two years suggests that today's educator should closely examine the topic--whether with a view toward promoting such options or simply in the interest of keeping abreast of major developments that affect American education. This bulletin gives an introductory overview of the…

Diabetes Topics Associated With Engagement on Twitter

PubMed Central

Mart, Adelina; Moreland-Russell, Sarah; Caburnay, Charlene A.

2015-01-01

Introduction Social media are widely used by the general public and by public health and health care professionals. Emerging evidence suggests engagement with public health information on social media may influence health behavior. However, the volume of data accumulating daily on Twitter and other social media is a challenge for researchers with limited resources to further examine how social media influence health. To address this challenge, we used crowdsourcing to facilitate the examination of topics associated with engagement with diabetes information on Twitter. Methods We took a random sample of 100 tweets that included the hashtag “#diabetes” from each day during a constructed week in May and June 2014. Crowdsourcing through Amazon’s Mechanical Turk platform was used to classify tweets into 9 topic categories and their senders into 3 Twitter user categories. Descriptive statistics and Tweedie regression were used to identify tweet and Twitter user characteristics associated with 2 measures of engagement, “favoriting” and “retweeting.” Results Classification was reliable for tweet topics and Twitter user type. The most common tweet topics were medical and nonmedical resources for diabetes. Tweets that included information about diabetes-related health problems were positively and significantly associated with engagement. Tweets about diabetes prevalence, nonmedical resources for diabetes, and jokes or sarcasm about diabetes were significantly negatively associated with engagement. Conclusion Crowdsourcing is a reliable, quick, and economical option for classifying tweets. Public health practitioners aiming to engage constituents around diabetes may want to focus on topics positively associated with engagement. PMID:25950569

Diabetes topics associated with engagement on Twitter.

PubMed

Harris, Jenine K; Mart, Adelina; Moreland-Russell, Sarah; Caburnay, Charlene A

2015-05-07

Social media are widely used by the general public and by public health and health care professionals. Emerging evidence suggests engagement with public health information on social media may influence health behavior. However, the volume of data accumulating daily on Twitter and other social media is a challenge for researchers with limited resources to further examine how social media influence health. To address this challenge, we used crowdsourcing to facilitate the examination of topics associated with engagement with diabetes information on Twitter. We took a random sample of 100 tweets that included the hashtag "#diabetes" from each day during a constructed week in May and June 2014. Crowdsourcing through Amazon's Mechanical Turk platform was used to classify tweets into 9 topic categories and their senders into 3 Twitter user categories. Descriptive statistics and Tweedie regression were used to identify tweet and Twitter user characteristics associated with 2 measures of engagement, "favoriting" and "retweeting." Classification was reliable for tweet topics and Twitter user type. The most common tweet topics were medical and nonmedical resources for diabetes. Tweets that included information about diabetes-related health problems were positively and significantly associated with engagement. Tweets about diabetes prevalence, nonmedical resources for diabetes, and jokes or sarcasm about diabetes were significantly negatively associated with engagement. Crowdsourcing is a reliable, quick, and economical option for classifying tweets. Public health practitioners aiming to engage constituents around diabetes may want to focus on topics positively associated with engagement.

A topical aqueous oxygen emulsion stimulates granulation tissue formation in a porcine second-degree burn wound.

PubMed

Li, Jie; Zhang, Yan-Ping; Zarei, Mina; Zhu, Linjian; Sierra, Jose Ollague; Mertz, Patricia M; Davis, Stephen C

2015-08-01

Oxygen is an essential substance for wound healing. Limited studies have shown that topical oxygen can influence healing. This study evaluated the effects of a Topical Oxygen Emulsion (TOE) on burn wound healing. A porcine second-degree burn wound model was used in the study. Burn wounds were randomly assigned to TOE, vehicle control, and no-treatment (air) groups. Effects of TOE on the granulation tissue formation and angiogenesis were studied using hematoxylin and eosin histological analysis. Protein production and gene expression of types I and III collagen and vascular endothelial growth factor (VEGF) were determined using immunofluorescent staining and Reverse Transcription and Polymerase Chain Reaction (RT-PCR), respectively. The TOE treated wounds exhibited better angiogenesis and granulation tissue formation by histology examination. The immunofluorescence staining and RT-PCR analysis demonstrated that protein production and mRNA expression of VEGF and collagen III were significantly higher in TOE treatment group than vehicle alone and air control groups, while there was no significant difference in the level of collagen I. Our data demonstrate that TOE enhances burn wound healing via stimulating the expression of VEGF and type III collagen and strongly indicates the potential use of TOE in wounds. Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.

Nontraditional approach to algebra-based general physics

NASA Astrophysics Data System (ADS)

Meltzer, David E.

1997-03-01

In order to improve the degree of conceptual learning in our algebra-based general physics course, the second semester (of a two-semester sequence) has been taught in a nontraditional format during the past year. The key characteristics of this course were: 1) Intense and continuous use of interactive-engagement methods and cooperative learning; 2) coverage of less than half of the conventional number of topics, 3) heavy emphasis on qualitative questions as opposed to quantitative problems, 4) adjustment of the pacing of the course based on continuous (twice per week) formative assessment. The students enrolled in the course were relatively poorly prepared, with weak mathematical skills. Open-book quizzes stressing qualitative concepts in electricity and magnetism were given twice per week; most were given in "group quiz" format, allowing collaboration. Exams (also open-book) were all done individually. Most of the class time was taken up by quizzes, and by interactive discussion and group work related to quiz questions. New topics were not introduced until a majority of the class demonstrated competence in the topic under discussion. Despite lengthy and intensive focus on qualitative, conceptual questions and simple quantitative problems, only a small minority of the class ultimately demonstrated mastery of the targeted concepts. Frequent testing and re-testing of the students on basic concepts disclosed tenacious persistence of misconceptions.

Framing Options as Choice or Opportunity: Does the Frame Influence Decisions?

PubMed

Abhyankar, Purva; Summers, Barbara A; Velikova, Galina; Bekker, Hilary L

2014-07-01

Health professionals must enable patients to make informed decisions about health care choices through unbiased presentation of all options. This study examined whether presenting the decision as "opportunity" rather than "choice" biased individuals' preferences in the context of trial participation for cancer treatment. Self-selecting healthy women (N = 124) were randomly assigned to the following decision frames: opportunity to take part in the trial (opt-in), opportunity to be removed from the trial (opt-out), and choice to have standard treatment or take part in the trial (choice). The computer-based task required women to make a hypothetical choice about a real-world cancer treatment trial. The software presented the framed scenario, recorded initial preference, presented comprehensive and balanced information, traced participants' use of information during decision making, and recorded final decision. A posttask paper questionnaire assessed perceived risk, attitudes, subjective norm, perceived behavioral control, and satisfaction with decision. Framing influenced women's immediate preferences. Opportunity frames, whether opt-in or opt-out, introduced a bias as they discouraged women from choosing standard treatment. Using the choice frame avoided this bias. The opt-out opportunity frame also affected women's perceived social norm; women felt that others endorsed the trial option. The framing bias was not present once participants had had the opportunity to view detailed information on the options within a patient decision aid format. There were no group differences in information acquisition and final decisions. Sixteen percent changed their initial preference after receiving full information. A "choice" frame, where all treatment options are explicit, is less likely to bias preferences. Presentation of full information in parallel, option-by-attribute format is likely to "de-bias" the decision frame. Tailoring of information to initial preferences would be ill-advised as preferences may change following detailed information. © The Author(s) 2014.

Some remarks on extragalactic globular clusters

NASA Astrophysics Data System (ADS)

Richtler, Tom

2006-03-01

I comment (in a review fashion) on a few selected topics in the field of extragalactic globular clusters with strong emphasis on recent work. The topics are: bimodality in the colour distribution of cluster systems, young massive clusters, and the brightest old clusters. Globular cluster research, per- haps more than ever, has lead to important (at least to astronomers) progress and problems in galaxy structure and formation.

A novel, volumizing cosmetic formulation significantly improves the appearance of target Glabellar lines, nasolabial folds, and crow's feet in a double-blind, vehicle-controlled clinical trial.

PubMed

Farris, Patricia K; Edison, Brenda L; Weinkauf, Ronni L; Green, Barbara A

2014-01-01

Facial lines and wrinkles are caused by many factors including constant exposure to external elements, such as UV rays, as well as the dynamic nature of facial expression. Many cosmetic products and procedures provide global improvement to aging skin, whereas injectable therapies are frequently utilized to diminish specific, target wrinkles. Despite their broad availability, some patients are unwilling to undergo injectables and would benefit from an effective topical option. A noninvasive option to volumize target wrinkle areas could also extend benefits of commonly used cosmetic anti-aging products. To this end, a two-step formulation containing the novel, cosmetic anti-aging ingredient, N-acetyl tyrosinamide, was developed for use on targeted wrinkle areas. The tolerability and efficacy of the serum plus cream were tested for 16 weeks in women with moderate facial photodamage on predetermined wrinkle areas (glabellar lines, nasolabial folds, under eye lines, and lateral canthal (crow's feet) wrinkles) in a single-center, randomized, double-blind, vehicle-controlled, clinical trial. Seventy women (47 Active group, 23 Vehicle group) completed the study. Digital photography, clinical grading, ultrasound and self-assessment scores confirmed improvement to wrinkle areas. The topical cosmetic formulation was statistically superior (P<0.05) to its vehicle in visually improving nasolabial folds, glabellar lines, crow's feet, and under eye wrinkles and in reducing pinch recoil time. Both the test formulation and its vehicle were tolerated well. The novel, two-step cosmetic formulation reduced the appearance of wrinkles and increased skin elasticity thus providing an effective anti-aging option for target wrinkle areas. This study suggests that in addition to its use as monotherapy for reducing targeted lines and wrinkles this cosmetic formulation may be also serve as an adjuvant to injectable therapies.

Patient Perceptions About Prediabetes and Preferences for Diabetes Prevention.

PubMed

O'Brien, Matthew J; Moran, Margaret R; Tang, Joyce W; Vargas, Maria C; Talen, Mary; Zimmermann, Laura J; Ackermann, Ronald T; Kandula, Namratha R

2016-12-01

The purpose of this study was to explore how adults with prediabetes perceive their risk of developing diabetes and examine their preferences for evidence-based treatment options to prevent diabetes. A qualitative study was conducted in 2 large Midwest primary care practices, involving in-depth semistructured interviews with 35 adult patients with prediabetes. This ethnically diverse (77% nonwhite) sample of middle-aged primary care patients exhibited multiple diabetes risk factors. Knowledge gaps about prediabetes and its medical management were pervasive. Most patients overestimated the risk of developing diabetes and were not familiar with evidence-based treatment options for prediabetes. They suggested that receiving brief, yet specific information about these topics during the study interview motivated them to act. The majority of participants considered both intensive lifestyle intervention and metformin acceptable treatment options. Many preferred initial treatment with intensive lifestyle intervention but would take metformin if their efforts at lifestyle change failed and their primary care physician recommended it. Some participants expressed wanting to combine both treatments. This qualitative study highlights potential opportunities to promote patient-centered dialogue about prediabetes in primary care settings. Providing patients specific information about the risk of developing diabetes and evidence-based treatment options to prevent or delay its onset may encourage action. Physicians' prediabetes counseling efforts should be informed by the finding that most patients consider both intensive lifestyle intervention and metformin acceptable treatment options. © 2016 The Author(s).

Current options for the treatment of pathological scarring.

PubMed

Poetschke, Julian; Gauglitz, Gerd G

2016-05-01

Scarring is the consequence of surgery, trauma or different skin diseases. Apart from fresh, immature scars,that transform into mature scars over the course of would healing and that do not require further treatment,linear hypertrophic scars, widespread hypertrophic scars, keloids and atrophic scars exist. Symptoms like pruritusand pain, stigmatization as well as functional and aesthetic impairments that are very disturbing for the affected patients can bethe basis for the desire for treatment. Today, a multitude of options for the treatment and prevention of scars exists. Topical agents based on silicone or onion extract, intralesional injections of cristalline glucocorticoids (oftentimes in combinationwith cryotherapy) or 5-Fluorouracil as well as ablative and nonablative laser treatment are used. Current guidelines summarize the multitude of available treatment options and the currently available datafor the treating physicians, allowing them to make clear therapy recommendations for every single scar type. Relieving patients of their discomfort and doing their aesthetic demands justice is thus possible. Apart from scar prevention becoming more and more important, the increased use of modernlaser treatment options constitutes a key point in clinical scar treatment. At the same time the attention is turned to evaluating current therapeutic options with the help of contemporary study designs so as to graduallyimprove the level of evidence in scar treatment. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

An experimental double-blind irradiation study of a novel topical product (TPF 50) compared to other topical products with DNA repair enzymes, antioxidants, and growth factors with sunscreens: implications for preventing skin aging and cancer.

PubMed

Emanuele, Enzo; Spencer, James M; Braun, Martin

2014-03-01

The exposure to ultraviolet radiation (UVR) is a major risk factor for skin aging and the development of non-melanoma skin cancer (NMSC). Although traditional sunscreens remain the mainstay for the prevention of UVR-induced skin damage, they cannot ensure a complete protection against the whole spectrum of molecular lesions associated with UVR exposure. The formation of helix-distorting photoproducts such as cyclobutane pyrimidine dimers (CPD), as well as oxidative damage to DNA bases, including the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8OHdG) are among the key DNA lesions associated with photoaging and tumorigenesis. Besides DNA lesions, UVR-induced formation of free radicals can result in protein carbonylation (PC), a major form of irreversible protein damage that inactivates their biological function. This study compares a complex novel topical product (TPF50) consisting of three actives, ie, 1) traditional physical sunscreens (SPF 50), 2) a liposome-encapsulated DNA repair enzymes complex (photolyase, endonuclease, and 8-oxoguanine glycosylase [OGG1]), and 3) a potent antioxidant complex (carnosine, arazine, ergothionine) to existing products. Specifically, we assessed the ability of TFP50 vs those of DNA repair and antioxidant and growth factor topical products used with SPF 50 sunscreens in preventing CPD, 8OHdG, and PC formation in human skin biopsies after experimental irradiations. In head-to-head comparison studies, TPF50 showed the best efficacy in reducing all of the three molecular markers. The results indicated that the three TPF50 components had a synergistic effect in reducing CPD and PC, but not 8OHdG. Taken together, our results indicate that TPF50 improves the genomic and proteomic integrity of skin cells after repeated exposure to UVR, ultimately reducing the risk of skin aging and NMSC.

Reformers or Roadblocks: Educational Interest Groups and State Policy Formation

ERIC Educational Resources Information Center

Emerson, Joseph; Lemasters, Linda; Howerton, Everett

2008-01-01

Given the overt political nature of this topic, an additional theoretical postulate, the Triadic Theory of Power was also presented as another framework to conceptualize the external and internal forces which shape the formation of contemporary education policy. Predicated upon the scholarship of Nobel laureate James Q. Wilson, Andrew McFarland…

The Evolution of Galaxies and Their Environment

NASA Technical Reports Server (NTRS)

Hollenbach, David (Editor); Thronson, Harley A. (Editor); Shull, J. Michael (Editor)

1993-01-01

The Third Teton Summer School on Astrophysics discussed the formation of galaxies, star formation in galaxies, galaxies and quasars at high red shift, and the intergalactic and intercluster medium and cooling flows. Observation and theoretical research on these topics was presented at the meeting and summaries of the contributed papers are included in this volume.

76 FR 13003 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... PULSe workstation. The Exchange is also proposing to make a non-substantive formatting change to its Fee... related to the PULSe workstation. The Exchange is also proposing to make a non-substantive formatting change to its Fee Schedule. By way of background, the PULSe workstation is a front-end order entry system...

Online and Hybrid Water Industry Courses for Community College Students

ERIC Educational Resources Information Center

Campbell, Chelsea

2017-01-01

The Water Quality Management Technology department at Red Rocks Community College in Denver, CO received a National Science Foundation grant and converted 24 courses from a face-to-face format to online and hybrid formats. The courses were converted to meet a growing employment need within the water industry. The online and hybrid options gave…

The Effect of Position and Format on the Difficulty of Assessment Exercises.

ERIC Educational Resources Information Center

Burton, Nancy W.; And Others

Assessment exercises (items) in three different formats--multiple-choice with an "I don't know" (IDK) option, multiple-choice without the IDK, and open-ended--were placed at the beginning, middle and end of 45-minute assessment packages (instruments). A balanced incomplete blocks analysis of variance was computed to determine the biasing…

A study of topics for distance education-A survey of U.S. Fish and Wildlife Service employees

USGS Publications Warehouse

Ratz, Joan M.; Schuster, Rudy M.; Marcy, Ann H.

2011-01-01

The purpose of this study was to identify training topics and distance education technologies preferred by U.S. Fish and Wildlife Service employees. This study was conducted on behalf of the National Conservation Training Center to support their distance education strategy planning and implementation. When selecting survey recipients, we focused on employees in positions involving conservation and environmental education and outreach programming. We conducted the study in two phases. First, we surveyed 72 employees to identify useful training topics. The response rate was 61 percent; respondents were from all regions and included supervisors and nonsupervisors. Five topics for training were identified: creating and maintaining partnerships (partnerships), technology, program planning and development (program planning), outreach methods to engage the community (outreach methods), and evaluation methods. In the second phase, we surveyed 1,488 employees to assess preferences for training among the five topics identified in the first survey and preferences among six distance education technologies: satellite television, video conferencing, audio conferencing, computer mediated training, written resources, and audio resources. Two types of instructor-led training were included on the survey to compare to the technology options. Respondents were asked what types of information, such as basic facts or problem solving skills, were needed for each of the five topics. The adjusted response rate was 64 percent; respondents were from all regions and included supervisors and nonsupervisors. The results indicated clear preferences among respondents for certain training topics and technologies. All five training topics were valued, but the topics of partnerships and technology were given equal value and were valued more than the other three topics. Respondents indicated a desire for training on the topics of partnerships, technology, program planning, and outreach methods. For the six distance education technologies, respondents indicated different levels of usability and access. Audio conferencing and written resources were reported to be most usable and accessible. The ratings of technology usability/access differed according to region; respondents in region 9 rated most technologies higher on usability/access. Respondents indicated they would take courses through either onsite or distance education approaches, but they prefer onsite training for most topics and most types of information.

Is cognitive science usefully cast as complexity science?

PubMed

Van Orden, Guy; Stephen, Damian G

2012-01-01

Readers of TopiCS are invited to join a debate about the utility of ideas and methods of complexity science. The topics of debate include empirical instances of qualitative change in cognitive activity and whether this empirical work demonstrates sufficiently the empirical flags of complexity. In addition, new phenomena discovered by complexity scientists, and motivated by complexity theory, call into question some basic assumptions of conventional cognitive science such as stable equilibria and homogeneous variance. The articles and commentaries that appear in this issue also illustrate a new debate style format for topiCS. Copyright © 2011 Cognitive Science Society, Inc.

A nationwide survey of healthcare personnel's attitude, knowledge, and interest toward renal supportive care in Taiwan.

PubMed

Tsai, Hung-Bin; Chao, Chia-Ter; Huang, Jenq-Wen; Chang, Ray-E; Hung, Kuan-Yu

2017-01-01

Renal supportive care (RSC) is an important option for elderly individuals reaching end-stage renal disease; however, the frequency of RSC practice is very low among Asian countries. We evaluated the attitude, the knowledge, and the preference for specific topics concerning RSC among participants who worked in different medical professions in Taiwan. A cross-sectional questionnaire-based survey was employed. Healthcare personnel ( N  = 598) who were involved in caring for end-stage renal disease patients at more than 40 facilities in Taiwan participated in this study. Participants were asked about their motivation for learning about RSC, the topics of RSC they were most and least interested in, their willingness to provide RSC, and to rate their knowledge and perceived importance of different topics. The vast majority of respondents (81.9%) were self-motivated about RSC, among whom nephrologists (96.8%) and care facilitators (administrators/volunteers) (45%) exhibited the highest and the least motivation, respectively ( p  < 0.01). Overall, respondents indicated that they had adequate knowledge about the five pre-specified RSC topics between medical professions ( p  = 0.04). Medical professions and institutional size exerted significant influence on the willingness to provide RSC. Our results facilitate the understanding of the knowledge and attitude toward different RSC topics among varied medical professions, and can guide the design of RSC education content for healthcare personnel.

Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis.

PubMed

Hoy, Sheridan M

2017-12-01

Crisaborole ointment 2% (Eucrisa™) is a novel, anti-inflammatory inhibitor of phosphodiesterase 4 (PDE4) that is available in the USA for the topical treatment of mild to moderate atopic dermatitis in patients aged ≥ 2 years. In two short-term (28 days), identically designed, multicentre, phase III studies in this patient population, topical therapy with crisaborole ointment 2% reduced disease severity and pruritus severity compared with vehicle, with the effect established early and sustained over the course of treatment. Improvements in the other signs of atopic dermatitis (erythema, exudation, excoriation, induration/papulation, and lichenification) were also seen. Crisaborole ointment 2% was generally well tolerated in the short-term studies, with its favorable safety profile maintained over the longer term (up to 52 weeks) in a multicentre, extension study. Most treatment-emergent adverse events (TEAEs) were of mild to moderate severity and considered unrelated to the study medication. Moreover, the incidence of application-site pain following short- and longer-term topical therapy with crisaborole ointment 2% was low. In conclusion, crisaborole ointment 2% is an effective and generally well tolerated new topical option for the management of mild to moderate atopic dermatitis in patients aged ≥ 2 years, with the potential to effectively treat this patient population over the longer term without the safety concerns associated with other current topical anti-inflammatory agents.

NDMA formation from amine-based pharmaceuticals--impact from prechlorination and water matrix.

PubMed

Shen, Ruqiao; Andrews, Susan A

2013-05-01

The presence of N-nitrosodimethylamine (NDMA) in drinking water is most commonly associated with the chloramination of amine-based precursors. One option to control the NDMA formation is to remove the precursors via pre-oxidation, and prechlorination is among the most effective options in reducing NDMA formation. However, most of the findings to-date are based on single-precursor scenarios using the model precursor dimethylamine (DMA) and natural organic matter (NOM), while few studies have considered the potential interactions between water matrix components and the target precursors when investigating the prechlorination impact. Specifically, little is known for the behaviour of amine-based pharmaceuticals which have recently been reported to contribute to NDMA formation upon chloramination. This work demonstrates that prechlorination can affect both the ultimate NDMA conversion and the reaction kinetics from selected pharmaceuticals, and the nature and extent of the impact was compound-specific and matrix-specific. In the absence of NOM, the NDMA formation from most pharmaceuticals was reduced upon prechlorination, except for sumatriptan which showed a consistent increase in NDMA formation with increasing free chlorine contact time. In the presence of NOM, prechlorination was shown to enhance initial reactions by reducing the binding between NOM and pharmaceuticals, but prolonged prechlorination broke down NOM into smaller products which could then form new bonds with pharmaceuticals and thus inhibit their further conversion into NDMA. Copyright © 2013 Elsevier Ltd. All rights reserved.

The emerging role of the client in the delivery of primary care to older Americans.

PubMed Central

Counte, M A

1998-01-01

OBJECTIVE: To address the likely influences, on options faced by older clients, of specific changes in the delivery system and several possible responses to these changes and the changed options, by older persons in the aggregate. STUDY DESIGN: Four specific topics are discussed at length: (1) the probable altered role for the older healthcare client brought on by organizational changes; (2) findings from research on elderly health maintenance behavior and reasons for the increased importance of this issue; (3) the effectiveness of the conventional approach to explaining health services utilization in population studies; and (4) recommendations for future research into the direct or indirect influence of organizational changes in the primary healthcare system on the health-related decisions and behaviors of older persons. PMID:9618677

Information presentation format moderates the unconscious-thought effect: The role of recollection.

PubMed

Abadie, Marlène; Waroquier, Laurent; Terrier, Patrice

2016-09-01

The unconscious-thought effect occurs when distraction improves complex decision-making. In two experiments using the unconscious-thought paradigm, we investigated the effect of presentation format of decision information (i) on memory for decision-relevant information and (ii) on the quality of decisions made after distraction, conscious deliberation or immediately. We used the process-dissociation procedure to measure recollection and familiarity. The two studies showed that presenting information blocked per criterion led participants to recollect more decision-relevant details compared to a presentation by option. Moreover, a Bayesian meta-analysis of the two studies provided strong evidence that conscious deliberation resulted in better decisions when the information was presented blocked per criterion and substantial evidence that distraction improved decision quality when the information was presented blocked per option. Finally, Study 2 revealed that the recollection of decision-relevant details mediated the effect of presentation format on decision quality in the deliberation condition. This suggests that recollection contributes to conscious deliberation efficacy.

Comparison of Modes of Administration and Response Options in the Assessment of Subjective Health Using the First Question of SF-36

ERIC Educational Resources Information Center

Mendes, Salome; Severo, Milton; Lopes, Carla

2012-01-01

To compare two modes of administration (self-administered; by interviewer) and two response options format (using words; images of "facial-expressions") of the first question of SF-36 (Q1SF-36), and to test its validity. We included 825 participants (20-90 years). Q1SF-36, using words or images, was included in a global questionnaire interview and…

REVIEWS OF TOPICAL PROBLEMS: Large-scale star formation in galaxies

NASA Astrophysics Data System (ADS)

Efremov, Yurii N.; Chernin, Artur D.

2003-01-01

A brief review is given of the history of modern ideas on the ongoing star formation process in the gaseous disks of galaxies. Recent studies demonstrate the key role of the interplay between the gas self-gravitation and its turbulent motions. The large scale supersonic gas flows create structures of enhanced density which then give rise to the gravitational condensation of gas into stars and star clusters. Formation of star clusters, associations and complexes is considered, as well as the possibility of isolated star formation. Special emphasis is placed on star formation under the action of ram pressure.

Particle rings and astrophysical accretion discs

NASA Astrophysics Data System (ADS)

Lovelace, R. V. E.; Romanova, M. M.

2016-03-01

Norman Rostoker had a wide range of interests and significant impact on the plasma physics research at Cornell during the time he was a Cornell professor. His interests ranged from the theory of energetic electron and ion beams and strong particle rings to the related topics of astrophysical accretion discs. We outline some of the topics related to rings and discs including the Rossby wave instability which leads to formation of anticyclonic vortices in astrophysical discs. These vorticies are regions of high pressure and act to trap dust particles which in turn may facilitate planetesimals growth in proto-planetary disks and could be important for planet formation. Analytical methods and global 3D magneto-hydrodynamic simulations have led to rapid advances in our understanding of discs in recent years.

An incurable itch

PubMed Central

Smith, Christine H.; Goldman, Ran D.

2012-01-01

Abstract Question Head lice infestations continue to be seen frequently in many communities. Some of these children require multiple treatments before eradication. What are the current treatment recommendations for head lice? Answer Head lice (Pediculus humanus capitis) infestations are common, particularly among school-aged children. In order to minimize louse resistance, insecticide usage, and social stigmatization, diagnosis and treatment should be limited to those with live lice on the scalp. Options for management are predominantly topical therapies or physical removal. Large studies comparing the efficacy of these treatments are lacking. Treatment should be repeated in approximately 7 days if topical insecticides are used or every 2 to 3 days for 2 weeks if wet combing is used. Lice resistance patterns vary widely geographically, and resistance is now the most common cause of treatment failure. PMID:22893334

[S2k-Guideline on Meniscal Disease: Non-operative and Surgical Management].

PubMed

Siebert, Christian H; Becker, Roland; Buchner, Matthias; Förster, Jürgen; Frosch, Karl-Heinz; Losch, Andreas; Niemeyer, Philipp; Scheffler, Sven

2018-03-12

A meniscal injury should not automatically lead to surgery. Even in light of all the developments in arthroscopic surgery, non-operative management still has a place in the treatment algorithms for lesions around the knee. In this second publication of the German guidelines for meniscal surgery, the authors describe the various treatment possibilities, their indications and offer critical insight into the various therapeutic options. This will allow the patient and physician alike to make the proper individual decisions. Various German speaking associations addressing topics surrounding the knee have joined forces to develop these guidelines for meniscal lesions. The hope is that these two publications on the topic will shed light on the ongoing debate and offer some guidance. Georg Thieme Verlag KG Stuttgart · New York.

Glaucoma management: relative value and place in therapy of available drug treatments

PubMed Central

Sambhara, Deepak

2014-01-01

Lowering intraocular pressure (IOP) is the only proven therapeutic intervention for glaucomatous optic neuropathy. Despite advances in laser and microsurgical techniques, medical IOP reduction remains the first-line treatment option for the majority of patients with open-angle glaucoma. Prostaglandin analogs are the most efficacious topical agents and carry a remarkable safety profile. Topical beta-blockers, alpha-agonists, and carbonic anhydrase inhibitors are often employed as adjunctive agents for further IOP control. Newer preserved and nonpreserved formulations are available and appear to be less toxic to the ocular surface. Oral carbonic anhydrase inhibitors, miotic agents, and hyperosmotics are infrequently used due to a host of potentially serious adverse events. Medical therapies on the horizon include rho-kinase inhibitors, neuroprotective interventions, and gene therapies. PMID:24381726

An incurable itch: head lice.

PubMed

Smith, Christine H; Goldman, Ran D

2012-08-01

Head lice infestations continue to be seen frequently in many communities. Some of these children require multiple treatments before eradication. What are the current treatment recommendations for head lice? Head lice (Pediculus humanus capitis) infestations are common, particularly among school-aged children. In order to minimize louse resistance, insecticide usage, and social stigmatization, diagnosis and treatment should be limited to those with live lice on the scalp. Options for management are predominantly topical therapies or physical removal. Large studies comparing the efficacy of these treatments are lacking. Treatment should be repeated in approximately 7 days if topical insecticides are used or every 2 to 3 days for 2 weeks if wet combing is used. Lice resistance patterns vary widely geographically, and resistance is now the most common cause of treatment failure.

Theory and laboratory astrophysics

NASA Technical Reports Server (NTRS)

Schramm, David N.; Mckee, Christopher F.; Alcock, Charles; Allamandola, Lou; Chevalier, Roger A.; Cline, David B.; Dalgarno, Alexander; Elmegreen, Bruce G.; Fall, S. Michael; Ferland, Gary J.

1991-01-01

Science opportunities in the 1990's are discussed. Topics covered include the large scale structure of the universe, galaxies, stars, star formation and the interstellar medium, high energy astrophysics, and the solar system. Laboratory astrophysics in the 1990's is briefly surveyed, covering such topics as molecular, atomic, optical, nuclear and optical physics. Funding recommendations are given for the National Science Foundation, NASA, and the Department of Energy. Recommendations for laboratory astrophysics research are given.

A water-based topical Chinese traditional medicine (Zicao) for wound healing developed using 2-hydroxypropyl-β-cyclodextrin.

PubMed

Chen Chen, Ta; Yu, Song-Cu; Hsu, Chin-Mu; Tsai, Fuu-Jen; Tsai, Yuhsin

2018-05-01

Zicao is a traditional Chinese herbal medicine that has been used for the topical treatment of wounds in the form of oil-based ointment for several hundred years. To overcome the disadvantages of oil-based ointment such as irritation, discomfort, and difficulty in cleaning, this study developed a water-based topical formulation of Zicao. An ethanol extract of Zicao was included in 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) to form a water-soluble Zicao-HP-β-CD complex. The formation of the Zicao-HP-β-CD complex was determined using LC-MS, 1 H NMR, ROSEY, and solubility analysis. The bioactivity of Zicao-HP-β-CD complex in aqueous solution was evaluated using cellular uptake in vitro and experimental excision wounds in vivo. The LC-MS, 1 H NMR, ROESY, and solubility analyses results show that Zicao extract was successfully included by the HP-β-CD. The results of the cellular uptake in vitro and wound healing in vivo suggest that the effect of Zicao was enhanced following the formation of the Zicao-HP-β-CD complex. Therefore, we concluded that complexation with HP-β-CD might provide a potential method for developing an effective water-based topical solution of Zicao. Copyright © 2018 Elsevier B.V. All rights reserved.

Automation: triumph or trap?

PubMed

Smythe, M H

1997-01-01

Automation, a hot topic in the laboratory world today, can be a very expensive option. Those who are considering implementing automation can save time and money by examining the issues from the standpoint of an industrial/manufacturing engineer. The engineer not only asks what problems will be solved by automation, but what problems will be created. This article discusses questions that must be asked and answered to ensure that automation efforts will yield real and substantial payoffs.

Interview with Audrey Jung, President of the International Society for Mental Health Online (ISMHO), Presented at the Online Counselling and Therapy in Action Conference, 25 April 2009

ERIC Educational Resources Information Center

Anthony, Kate; Jung, Audrey; Rosenauer, Dominik; Nagel, Deeanna Merz; Goss, Stephen

2010-01-01

Counselling services provided online have become an increasingly important topic over the last decade. It is now incumbent on all practitioners at least to be aware of the impact of online living for their clients and of the options available for online counselling provision. In this article, Kate Anthony of the Online Therapy Institute interviews…

Treatment options in painful diabetic neuropathy.

PubMed

Nash, T P

1999-01-01

Diabetic neuropathy is common in patients with diabetes mellitus, and 7.5% of diabetics experience pain from diabetic neuropathy. Complications of diabetes mellitus are more common where control of the disease is not optimal. By improving the control of the disease, both the neuropathy and the pain it can produce may be improved. The pain of diabetic neuropathy can frequently be controlled using analgesics, antidepressants, anticonvulsants, topical capsaicin, and neuromodulation, either alone or in any combination.

Management of familial benign chronic pemphigus

PubMed Central

Arora, Harleen; Bray, Fleta N; Cervantes, Jessica; Falto Aizpurua, Leyre A

2016-01-01

Benign familial chronic pemphigus or Hailey–Hailey disease is caused by an autosomal dominant mutation in the ATP2C1 gene leading to suprabasilar acantholysis. The disease most commonly affects intertriginous areas symmetrically. The chronic nature of the disease and multiple recurrences make the disease bothersome for patients and a treatment challenge for physicians. Treatments include topical and/or systemic agents and surgery including laser. This review summarizes the available treatment options. PMID:27695354

The Forbidden World of Off the Record Negotiating for Successful Air Force Media Engagements

DTIC Science & Technology

2012-02-15

reporters choose OTR as a first option. Since all parties perform a mental calculus of risks versus rewards before agreeing to OTR, the author...experience, calling OTR “the most often misunderstood” attribution category.15 One widely used journalism textbook says only that OTR is information... textbook , used at Columbia Journalism School, pays scant discussion to such a fundamental topic. In the 596-page textbook , discussion about attribution

Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis.

PubMed

Tieppo Francio, Vinicius; Davani, Saeid; Towery, Chris; Brown, Tony L

2017-06-01

Osteoarthritis (OA) is one of the most common causes of joint pain in the United States and non-steroidal anti-inflammatories (NSAIDs), such as Diclofenac sodium, which is currently available in two main routes of administration; oral and topical distribution have been established as one of the standard treatments for OA. Generally, oral NSAIDs are well tolerated; however our narrative review suggests that the topical solution had a better tolerability property than oral Diclofenac sodium, especially due to side effects of gastrointestinal bleeding with the utilization of the oral format. In addition, the topical route may be considered a reasonable selection by clinicians for management of musculoskeletal pain in those patients with a history of potential risk and adverse side effects. Most studies reviewed comparing oral versus topical solution of Diclofenac sodium revealed comparable efficacy, with minimal side effects utilizing the topical route. The key point of this narrative review is to help clinicians that currently must decide between very inexpensive diclofenac oral presentations and expensive topical presentations especially in the elderly population and the pros and cons of such decision-making process.

Nasal mucosa healing after endoscopic sinus surgery in chronic rhinosinusitis of elderly patients: role of topic alpha-tocopherol acetate.

PubMed

Testa, Domenico; Marcuccio, Giuseppina; Panin, Giorgio; Bianco, Andrea; Tafuri, Domenico; Thyrion, Francesco Zappoli; Nunziata, Michele; Piombino, Pasquale; Guerra, Germano; Motta, Gaetano

2017-02-01

Chronic rhinosinusitis (CRS) in European country ranges in elderly patients from 4.5 to 12% of population and has a significant effect on quality of life. In these patients, rhinosinusitis is linked to immune functions changes with age and to mucosal paraphysiological alterations such as crusting formations with atrophic epithelium, variations of nasal airflow and modifications of the mucociliary clearance. Failure of medical treatments leads to surgery in patients with persistent symptoms and radiographic signs of CRS. The choice of appropriate post-surgical topic treatments is important for healing time and for preventing mucosal complications such as synechiae, crusting formation and atrophy with secondary bacterial and fungal infections. Defining the effects of topic alpha-tocopherol acetate administration on nasal mucosa healing after endoscopic sinus surgery in CRS of elderly patients. In this study were included 32 patients, mean age 68.6, who underwent FESS because affected by CRS not responsive to medical treatments. After surgical treatment, we distinguish two groups basing on local nasal therapy. We investigated, in the postoperative time, the role of alpha-tocopherol acetate compared to gomenol oil. Follow-up was performed at 7-15 days and 1-3 months after surgery. We evaluated mucosal restoration using Rhinoscopy Sum Score and quality of life using Nasal Six Items Symptom Questionnaire. We observed a faster healing time and less recurrence of complications in patients who underwent topic treatment with alpha-tocopherol acetate. In our research, we observed that alpha-tocopherol acetate has no contraindications and side effects. Our study showed the effectiveness of alpha-tocopherol acetate topic treatment in elderly patients affected by CRS after FESS, in improving and speeding up the process of restoring the sinonasal mucosa, compared to another topic medication.

The Effects of Topical Agent (Kelo-Cote or Contractubex) Massage on the Thickness of Post-Burn Scar Tissue Formed in Rats

PubMed Central

Ko, Won Jin; Suh, Bum Sin; Kim, Hyeon A; Heo, Woo Hoe; Choi, Gum Ha; Lee, Seo Ul

2013-01-01

Background We conducted an experimental study to compare the effect of massage using topical agents (Kelo-cote or Contractubex) on scar formation by massaging the healed burn wound on the dorsal area of Sprague-Dawley (SD) rats. Methods Four areas of second degree contact burn were made on the dorsal area of each of 15 SD rats, using a soldering iron 15 mm in diameter. After gross epithelialization in the defect, 15 SD rats were randomly divided into four groups: the Kelo-cote group, Contractubex group, Vaseline group, and control group. Rats in three of the groups (all but the Control group) were massaged twice per day for 5 minutes each day, while those in the Control group were left unattended. For histologic analysis, we performed a biopsy and evaluated the thickness of scar tissue. Results In the Kelo-cote and Contractubex groups, scar tissue thicknesses showed a significant decrease, compared with the Vaseline and control groups. However, no significant differences were observed between the Kelo-cote and Contractubex groups. In the Vaseline group, scar tissue thicknesses showed a significant decrease, compared with the control groups. Conclusions The findings of this study suggest that massage using a topical agent is helpful in the prevention of scar formation and that massage only with lubricant (no use of a topical agent) also has a considerable effect, although not as much as the use of a topical agent. Thus, we recommend massage with a topical agent on the post-burn scar as an effective method for decreasing the scar thickness. PMID:24286041

Evaluation of eLearning for the teaching of undergraduate ophthalmology at medical school: a randomised controlled crossover study.

PubMed

Petrarca, Caroline A; Warner, Julia; Simpson, Andrew; Petrarca, Robert; Douiri, Abdel; Byrne, David; Jackson, Timothy L

2018-05-25

To compare ophthalmology teaching delivered by eLearning with traditional lectures, in terms of undergraduate performance and satisfaction. Randomised controlled crossover study at King's College London Medical School with 245 third year medical students. The ophthalmology syllabus was divided into ten topics. Five topics were randomised to be taught by traditional lectures and five by electronic learning (eLearning). For the second rotation of students the topics were crossed over, so that those topics taught by traditional lectures were taught by eLearning and vice versa. At the end of each rotation the students sat an optional online mock examination containing 100 questions (ten on each topic). Students' examination performance was compared between the two teaching methods. Student satisfaction was assessed using an online satisfaction survey. Outcome measures were the mean percentage of correct answers across all ten topics, student satisfaction and self-assessed knowledge. The mean examination score for questions taught by eLearning was 58% (95% CI, 55.7-59.6), versus 55% (95% CI 53.1-56.8) for traditional lectures (P = 0.047). Across all topics students were more satisfied with eLearning than traditional lectures, with 87% (95% CI 84.5-88.4) rating eLearning as 'excellent' or 'good' versus 65% (95% CI 62.0-67.4) for lectures (p < 0.0001). Overall 180 (75.6%) preferred eLearning compared to traditional lectures, with 166 (69.7%) rating eLearning 'much better' or 'better,' 61 (25.6%) 'neutral' and 11 (4.6%) 'worse' or 'much worse.' Student satisfaction and examination performance are both enhanced by ophthalmology eLearning. Similar eLearning modules may be suitable for other specialties and postgraduate learning.

The effectiveness of the bone bridge transtibial amputation technique: A systematic review of high-quality evidence.

PubMed

Kahle, Jason T; Highsmith, M Jason; Kenney, John; Ruth, Tim; Lunseth, Paul A; Ertl, Janos

2017-06-01

This literature review was undertaken to determine if commonly held views about the benefits of a bone bridge technique are supported by the literature. Four databases were searched for articles pertaining to surgical strategies specific to a bone bridge technique of the transtibial amputee. A total of 35 articles were identified as potential articles. Authors included methodology that was applied to separate topics. Following identification, articles were excluded if they were determined to be low quality evidence or not pertinent. Nine articles were identified to be pertinent to one of the topics: Perioperative Care, Acute Care, Subjective Analysis and Function. Two articles sorted into multiple topics. Two articles were sorted into the Perioperative Care topic, 4 articles sorted into the Acute Care topic, 2 articles into the Subjective Analysis topic and 5 articles into the Function topic. There are no high quality (level one or two) clinical trials reporting comparisons of the bone bridge technique to traditional methods. There is limited evidence supporting the clinical outcomes of the bone bridge technique. There is no agreement supporting or discouraging the perioperative and acute care aspects of the bone bridge technique. There is no evidence defining an interventional comparison of the bone bridge technique. Current level III evidence supports a bone bridge technique as an equivalent option to the non-bone bridge transtibial amputation technique. Formal level I and II clinical trials will need to be considered in the future to guide clinical practice. Clinical relevance Clinical Practice Guidelines are evidence based. This systematic literature review identifies the highest quality evidence to date which reports a consensus of outcomes agreeing bone bridge is as safe and effective as alternatives. The clinical relevance is understanding bone bridge could additionally provide a mechanistic advantage for the transtibial amputee.

Formative Assessment Pre-Test to Identify College Students' Prior Knowledge, Misconceptions and Learning Difficulties in Biology

ERIC Educational Resources Information Center

Lazarowitz, Reuven; Lieb, Carl

2006-01-01

A formative assessment pretest was administered to undergraduate students at the beginning of a science course in order to find out their prior knowledge, misconceptions and learning difficulties on the topic of the human respiratory system and energy issues. Those findings could provide their instructors with the valuable information required in…

Comparing Two Cooperative Small Group Formats Used with Physical Therapy and Medical Students

ERIC Educational Resources Information Center

D'Eon, Marcel; Proctor, Peggy; Reeder, Bruce

2007-01-01

This study compared "Structured Controversy" (a semi-formal debate like small group activity) with a traditional open discussion format for medical and physical therapy students. We found that those students who had participated in Structured Controversy changed their personal opinion on the topic more than those who were in the Open Discussion…

Formative Assessment and Increased Student Involvement Increase Grades in an Upper Secondary School Biology Course

ERIC Educational Resources Information Center

Granbom, Martin

2016-01-01

This study shows that formative methods and increased student participation has a positive influence on learning measured as grades. The study was conducted during the course Biology A in a Swedish Upper Secondary School. The students constructed grade criteria and defined working methods and type of examination within a given topic, Gene…

Evaluation of Automatic Item Generation Utilities in Formative Assessment Application for Korean High School Students

ERIC Educational Resources Information Center

Choi, Jaehwa; Kim, HeeKyoung; Pak, Seohong

2018-01-01

The recent interests in research in the assessment field have been rapidly shifting from decision-maker-centered assessments to learner-centered assessments (i.e., diagnostic and/or formative assessments). In particular, it is a very important research topic in this field to analyze how these learner-centered assessments are developed more…

Cosmochemical Studies: Meteorites and their Parent Asteroids

NASA Technical Reports Server (NTRS)

Wasson, John T.

2003-01-01

This a final technical report that focuses on cosmochemical studies of meteorites and their parent asteroids. The topics include: 1) Formation of iron meteorites and other metal rich meteorites; 2) New perspectives on the formation of chondrules; and 3) Consequences of large aerial bursts. Also a list of seven papers that received significant support from this research are included.

Historians or History Teachers? A Qualitative Study in Pedagogical Formation Program in Turkey

ERIC Educational Resources Information Center

Ünisen, Ali

2016-01-01

This study aims to determine how the history teaching career is perceived by prospective history teachers who attended the pedagogical formation program in Adiyaman University in 2014-2015 academic year. The study was conducted through content analysis of 5 sets of essays dealing with various aspects of history teaching. The essays topics were…

Using Percentages to Describe and Calculate Change

ERIC Educational Resources Information Center

Price, Beth; Steinle, Vicki; Stacey, Kaye; Gvozdenko, Eugene

2014-01-01

This study reports on the use of formative, diagnostic online assessments for the topic percentages. Two new item formats (drag-drop and slider) are described. About one-third of the school students (Years 7 to 9) could, using a slider, estimate "80% more than" a given length, in contrast with over two-thirds who could estimate "90%…

Technical Documentation Challenges in Aviation Maintenance: A Proceedings Report

DTIC Science & Technology

2012-11-01

ATP Keith Frable - -- - -- - -- - - ASO-27 Colin Drury - -- - -- - -- - - Applied Ergonomics Lynn Pierce - -- - -- - -- - - AEG-15 Dave...threaten safety and cost the industry millions of dollars. The workshop format combined key presentation topics, followed by structured discussion and...critical and can produce very different results for the end user, depending on the authoring tools and formatting selected. Cost influences document

The Use of Gaming in a Dental Hygiene Review Course.

ERIC Educational Resources Information Center

Peterson, Charlotte A.; Mauriello, Sally M.; Caplan, Daniel J.

2000-01-01

Evaluated the effectiveness of gaming to create an interactive, stimulating learning environment as a review format for the Dental Hygiene National Board examination. Students (n=28) participated in either the gaming or a lecture review format. The gaming group scored higher on the exam on eight of 12 topics as well as on the case-based learning…

Analysis and application of opinion model with multiple topic interactions.

PubMed

Xiong, Fei; Liu, Yun; Wang, Liang; Wang, Ximeng

2017-08-01

To reveal heterogeneous behaviors of opinion evolution in different scenarios, we propose an opinion model with topic interactions. Individual opinions and topic features are represented by a multidimensional vector. We measure an agent's action towards a specific topic by the product of opinion and topic feature. When pairs of agents interact for a topic, their actions are introduced to opinion updates with bounded confidence. Simulation results show that a transition from a disordered state to a consensus state occurs at a critical point of the tolerance threshold, which depends on the opinion dimension. The critical point increases as the dimension of opinions increases. Multiple topics promote opinion interactions and lead to the formation of macroscopic opinion clusters. In addition, more topics accelerate the evolutionary process and weaken the effect of network topology. We use two sets of large-scale real data to evaluate the model, and the results prove its effectiveness in characterizing a real evolutionary process. Our model achieves high performance in individual action prediction and even outperforms state-of-the-art methods. Meanwhile, our model has much smaller computational complexity. This paper provides a demonstration for possible practical applications of theoretical opinion dynamics.

The Effect of Data Format on Integration of Performance Data into Angoff Judgments

ERIC Educational Resources Information Center

Clauser, Brian E.; Mee, Janet; Margolis, Melissa J.

2013-01-01

This study investigated the extent to which the performance data format impacted data use in Angoff standard setting exercises. Judges from two standard settings (a total of five panels) were randomly assigned to one of two groups. The full-data group received two types of data: (1) the proportion of examinees selecting each option and (2) plots…