Online Learning Flight Control for Intelligent Flight Control Systems (IFCS)

NASA Technical Reports Server (NTRS)

Niewoehner, Kevin R.; Carter, John (Technical Monitor)

2001-01-01

The research accomplishments for the cooperative agreement 'Online Learning Flight Control for Intelligent Flight Control Systems (IFCS)' include the following: (1) previous IFC program data collection and analysis; (2) IFC program support site (configured IFC systems support network, configured Tornado/VxWorks OS development system, made Configuration and Documentation Management Systems Internet accessible); (3) Airborne Research Test Systems (ARTS) II Hardware (developed hardware requirements specification, developing environmental testing requirements, hardware design, and hardware design development); (4) ARTS II software development laboratory unit (procurement of lab style hardware, configured lab style hardware, and designed interface module equivalent to ARTS II faceplate); (5) program support documentation (developed software development plan, configuration management plan, and software verification and validation plan); (6) LWR algorithm analysis (performed timing and profiling on algorithm); (7) pre-trained neural network analysis; (8) Dynamic Cell Structures (DCS) Neural Network Analysis (performing timing and profiling on algorithm); and (9) conducted technical interchange and quarterly meetings to define IFC research goals.

Chronometric Electrical Stimulation of Right Inferior Frontal Cortex Increases Motor Braking

PubMed Central

Conner, Christopher R.; Aron, Adam R.; Tandon, Nitin

2013-01-01

The right inferior frontal cortex (rIFC) is important for stopping responses. Recent research shows that it is also activated when response emission is slowed down when stopping is anticipated. This suggests that rIFC also functions as a goal-driven brake. Here, we investigated the causal role of rIFC in goal-driven braking by using computer-controlled, event-related (chronometric), direct electrical stimulation (DES). We compared the effects of rIFC stimulation on trials in which responses were made in the presence versus absence of a stopping-goal (“Maybe Stop” [MS] vs “No Stop” [NS]). We show that DES of rIFC slowed down responses (compared with control-site stimulation) and that rIFC stimulation induced more slowing when motor braking was required (MS) compared with when it was not (NS). Our results strongly support a causal role of a rIFC-based network in inhibitory motor control. Importantly, the results extend this causal role beyond externally driven stopping to goal-driven inhibitory control, which is a richer model of human self-control. These results also provide the first demonstration of double-blind chronometric DES of human prefrontal cortex, and suggest that—in the case of rIFC—this could lead to augmentation of motor braking. PMID:24336725

Best practices of Building Information Modelling (BIM) implementation in design phase for construction project

NASA Astrophysics Data System (ADS)

Kasim, N.; Zainal Abidin, N. A.; Zainal, R.; Sarpin, N.; Rahim, M. H. I. Abd; Saikah, M.

2017-11-01

Implementation of Building Information Modelling (BIM) was expected to bring improvement in current practices of Malaysian construction industry. In the design phase, there is a lack of a ready pool of skilled workers who are able to develop BIM strategic plan and effectively utilise it. These create boundaries for BIM nature in Malaysian construction industry specifically in the design phase to achieve its best practices. Therefore, the objectives of this research are to investigate the current practices of BIM implementation in the design phase as well as the best practices factors of BIM implementation in the design phase. The qualitative research approach is carried out through semi-structured interviews with the designers of different organisations which adopt BIM in the design phase. Data collection is analysed by executing content analysis method. From the findings, the best practices factors of BIM implementation in design phase such as the incentive for BIM training, formal approach to monitoring automated Level of Detailing (LOD), run a virtual meeting and improve Industry Foundation Class (IFC). Thus, best practices factors which lead to practices improvements in the design phase of project development which subsequently improves the implementation of BIM in the design phase of Malaysian construction industry.

Understanding 'what' others do: mirror mechanisms play a crucial role in action perception.

PubMed

Avenanti, Alessio; Urgesi, Cosimo

2011-06-01

Neurophysiological and imaging studies suggest that the inferior frontal cortex (IFC) implements a mechanism that matches perceived actions to one's motor representation of similar actions (mirror mechanism) and recent lesion studies have also established that IFC is critical for action perception. However, to date causative evidence that action perception requires activation within the same populations of IFC neurons involved in action execution is lacking. In this issue, Cattaneo and colleagues provide the first direct evidence that mirror mechanisms in IFC influence action perception. We discuss the implications of these findings for the understanding of the functional role of mirror mechanisms.

Understanding ‘what’ others do: mirror mechanisms play a crucial role in action perception

PubMed Central

Avenanti, Alessio; Urgesi, Cosimo

2011-01-01

Neurophysiological and imaging studies suggest that the inferior frontal cortex (IFC) implements a mechanism that matches perceived actions to one’s motor representation of similar actions (mirror mechanism) and recent lesion studies have also established that IFC is critical for action perception. However, to date causative evidence that action perception requires activation within the same populations of IFC neurons involved in action execution is lacking. In this issue, Cattaneo and colleagues provide the first direct evidence that mirror mechanisms in IFC influence action perception. We discuss the implications of these findings for the understanding of the functional role of mirror mechanisms. PMID:21653637

Object Extraction in Cluttered Environments via a P300-Based IFCE

PubMed Central

He, Huidong; Xian, Bin; Zeng, Ming; Zhou, Huihui; Niu, Linwei; Chen, Genshe

2017-01-01

One of the fundamental issues for robot navigation is to extract an object of interest from an image. The biggest challenges for extracting objects of interest are how to use a machine to model the objects in which a human is interested and extract them quickly and reliably under varying illumination conditions. This article develops a novel method for segmenting an object of interest in a cluttered environment by combining a P300-based brain computer interface (BCI) and an improved fuzzy color extractor (IFCE). The induced P300 potential identifies the corresponding region of interest and obtains the target of interest for the IFCE. The classification results not only represent the human mind but also deliver the associated seed pixel and fuzzy parameters to extract the specific objects in which the human is interested. Then, the IFCE is used to extract the corresponding objects. The results show that the IFCE delivers better performance than the BP network or the traditional FCE. The use of a P300-based IFCE provides a reliable solution for assisting a computer in identifying an object of interest within images taken under varying illumination intensities. PMID:28740505

Attention Drives Synchronization of Alpha and Beta Rhythms between Right Inferior Frontal and Primary Sensory Neocortex

PubMed Central

Sacchet, Matthew D.; LaPlante, Roan A.; Wan, Qian; Pritchett, Dominique L.; Lee, Adrian K.C.; Hämäläinen, Matti; Moore, Christopher I.; Kerr, Catherine E.

2015-01-01

The right inferior frontal cortex (rIFC) is specifically associated with attentional control via the inhibition of behaviorally irrelevant stimuli and motor responses. Similarly, recent evidence has shown that alpha (7–14 Hz) and beta (15–29 Hz) oscillations in primary sensory neocortical areas are enhanced in the representation of non-attended stimuli, leading to the hypothesis that allocation of these rhythms plays an active role in optimal inattention. Here, we tested the hypothesis that selective synchronization between rIFC and primary sensory neocortex occurs in these frequency bands during inattention. We used magnetoencephalography to investigate phase synchrony between primary somatosensory (SI) and rIFC regions during a cued-attention tactile detection task that required suppression of response to uncertain distractor stimuli. Attentional modulation of synchrony between SI and rIFC was found in both the alpha and beta frequency bands. This synchrony manifested as an increase in the alpha-band early after cue between non-attended SI representations and rIFC, and as a subsequent increase in beta-band synchrony closer to stimulus processing. Differences in phase synchrony were not found in several proximal control regions. These results are the first to reveal distinct interactions between primary sensory cortex and rIFC in humans and suggest that synchrony between rIFC and primary sensory representations plays a role in the inhibition of irrelevant sensory stimuli and motor responses. PMID:25653364

Sulcal Polymorphisms of the IFC and ACC Contribute to Inhibitory Control Variability in Children and Adults

PubMed Central

Linzarini, Adriano; Dollfus, Sonia; Etard, Olivier; Orliac, François; Houdé, Olivier

2018-01-01

Abstract Inhibitory control (IC) is a core executive function that enables humans to resist habits, temptations, or distractions. IC efficiency in childhood is a strong predictor of academic and professional success later in life. Based on analysis of the sulcal pattern, a qualitative feature of cortex anatomy determined during fetal life and stable during development, we searched for evidence that interindividual differences in IC partly trace back to prenatal processes. Using anatomical magnetic resonance imaging (MRI), we analyzed the sulcal pattern of two key regions of the IC neural network, the dorsal anterior cingulate cortex (ACC) and the inferior frontal cortex (IFC), which limits the inferior frontal gyrus. We found that the sulcal pattern asymmetry of both the ACC and IFC contributes to IC (Stroop score) in children and adults: participants with asymmetrical ACC or IFC sulcal patterns had better IC efficiency than participants with symmetrical ACC or IFC sulcal patterns. Such additive effects of IFC and ACC sulcal patterns on IC efficiency suggest that distinct early neurodevelopmental mechanisms targeting different brain regions likely contribute to IC efficiency. This view shares some analogies with the “common variant–small effect” model in genetics, which states that frequent genetic polymorphisms have small effects but collectively account for a large portion of the variance. Similarly, each sulcal polymorphism has a small but additive effect: IFC and ACC sulcal patterns, respectively, explained 3% and 14% of the variance of the Stroop interference scores. PMID:29527565

Sulcal Polymorphisms of the IFC and ACC Contribute to Inhibitory Control Variability in Children and Adults.

PubMed

Tissier, Cloélia; Linzarini, Adriano; Allaire-Duquette, Geneviève; Mevel, Katell; Poirel, Nicolas; Dollfus, Sonia; Etard, Olivier; Orliac, François; Peyrin, Carole; Charron, Sylvain; Raznahan, Armin; Houdé, Olivier; Borst, Grégoire; Cachia, Arnaud

2018-01-01

Inhibitory control (IC) is a core executive function that enables humans to resist habits, temptations, or distractions. IC efficiency in childhood is a strong predictor of academic and professional success later in life. Based on analysis of the sulcal pattern, a qualitative feature of cortex anatomy determined during fetal life and stable during development, we searched for evidence that interindividual differences in IC partly trace back to prenatal processes. Using anatomical magnetic resonance imaging (MRI), we analyzed the sulcal pattern of two key regions of the IC neural network, the dorsal anterior cingulate cortex (ACC) and the inferior frontal cortex (IFC), which limits the inferior frontal gyrus. We found that the sulcal pattern asymmetry of both the ACC and IFC contributes to IC (Stroop score) in children and adults: participants with asymmetrical ACC or IFC sulcal patterns had better IC efficiency than participants with symmetrical ACC or IFC sulcal patterns. Such additive effects of IFC and ACC sulcal patterns on IC efficiency suggest that distinct early neurodevelopmental mechanisms targeting different brain regions likely contribute to IC efficiency. This view shares some analogies with the "common variant-small effect" model in genetics, which states that frequent genetic polymorphisms have small effects but collectively account for a large portion of the variance. Similarly, each sulcal polymorphism has a small but additive effect: IFC and ACC sulcal patterns, respectively, explained 3% and 14% of the variance of the Stroop interference scores.

The Effectiveness and Safety of a Homeopathic Medicinal Product in Pediatric Upper Respiratory Tract Infections With Fever

PubMed Central

van Haselen, Robert; Thinesse-Mallwitz, Manuela; Maidannyk, Vitaliy; Buskin, Stephen L.; Weber, Stephan; Keller, Thomas; Burkart, Julia; Klement, Petra

2016-01-01

We investigated the clinical effectiveness of a homeopathic add-on therapy in a pediatric subpopulation with upper respiratory tract infections (URTI) in a randomized, controlled, multinational clinical trial. Patients received either on-demand symptomatic standard treatment (ST-group) or the same ST plus a homeopathic medication (Influcid; IFC-group) for 7 days. Outcome assessment was based on symptom and fever resolution and the Wisconsin Upper Respiratory Symptom Survey–21 (WURSS-21). A total of 261 pediatric (<12 years) patients (130 IFC-group; 131 ST-group) were recruited in Germany and the Ukraine. The IFC-group used less symptomatic medication, symptoms resolved significantly earlier (P = .0001), had higher proportions of fever-free children from day 3 onwards, and the WURSS-assessed global disease severity was significantly less (P < .0001) during the entire URTI episode. One adverse event (vomiting) was possibly related to IFC. IFC as add-on treatment in pediatric URTI reduced global disease severity, shortened symptom resolution, and was safe in use. PMID:27493984

Neural correlates of dual-task effect on belief-bias syllogistic reasoning: a near-infrared spectroscopy study.

PubMed

Tsujii, Takeo; Watanabe, Shigeru

2009-09-01

Recent dual-process reasoning theories have explained the belief-bias effect, the tendency for human reasoning to be erroneously biased when logical conclusions are incongruent with beliefs about the world, by proposing a belief-based automatic heuristic system and logic-based demanding analytic system. Although these claims are supported by the behavioral finding that high-load secondary tasks enhance the belief-bias effect, the neural correlates of dual-task reasoning remain unknown. The present study therefore examined the relationship between dual-task effect and activity in the inferior frontal cortex (IFC) during belief-bias reasoning by near-infrared spectroscopy (NIRS). Forty-eight subjects participated in this study (MA=23.46 years). They were required to perform congruent and incongruent reasoning trials while responding to high- and low-load secondary tasks. Behavioral analysis showed that the high-load secondary task impaired only incongruent reasoning performance. NIRS analysis found that the high-load secondary task decreased right IFC activity during incongruent trials. Correlation analysis showed that subjects with enhanced right IFC activity could perform better in the incongruent reasoning trials, though subjects for whom right IFC activity was impaired by the secondary task could not maintain better reasoning performance. These findings suggest that the right IFC may be responsible for the dual-task effect in conflicting reasoning processes. When secondary tasks impair right IFC activity, subjects may rely on the automatic heuristic system, which results in belief-bias responses. We therefore offer the first demonstration of neural correlates of dual-task effect on IFC activity in belief-bias reasoning.

Case report and literature review: transient Inab phenotype and an agglutinating anti-IFC in a patient with a gastrointestinal problem.

PubMed

Yazer, Mark H; Judd, W John; Davenport, Robertson D; Dake, Louann R; Lomas-Francis, Christine; Hue-Roye, Kim; Powell, Vivien; Reid, Marion

2006-09-01

The Inab phenotype is a rare deficiency of all Cromer antigens. These antigens are carried on the decay-accelerating factor (DAF, CD55) molecule that is attached to the red blood cell (RBC) membrane by a glycosylphosphatidylinositol (GPI) anchor. Although typically inherited, an acquired and transient form of the Inab phenotype also exists. A patient with the triad of transient Inab phenotype, a direct-agglutinating anti-IFC, and gastrointestinal (GI) abnormalities is reported. An 18-month-old boy with gastroesophageal reflux disease requiring a feeding tube, milk and soy intolerance, and severe growth retardation, as well as vision and hearing deficits from cytomegalovirus infection, was identified when pretransfusion testing revealed a potent panagglutinin (titer > 2000 at 4 degrees C). This antibody did not react with Dr(a-) and IFC RBCs, and the autocontrol was negative. The patient's RBCs lacked CD55 by flow cytometric techniques but had normal levels of CD59 and antigens such as Yt(a) and Emm, carried on GPI-linked proteins, thus excluding paroxysmal nocturnal hemoglobinuria. Several months after initial detection, the anti-IFC was virtually undetectable and his cells reacted weakly with anti-IFC, anti-Dr(a), and anti-CD55. RBCs from the propositus' parents and brother demonstrated normal CD55 and CD59 expression. This is the first example of a direct-agglutinating anti-IFC. The cause of the transient depression in CD55 protein (and thus Cromer system antigens) and appearance of anti-IFC remains unknown, as does the relationship between the patient's GI system abnormalities and these serologic findings.

Is Interferential Current Before Pilates Exercises More Effective Than Placebo in Patients With Chronic Nonspecific Low Back Pain?: A Randomized Controlled Trial.

PubMed

Franco, Katherinne Moura; Franco, Yuri Dos Santos; Oliveira, Naiane Bastos de; Miyamoto, Gisela Cristiane; Santos, Matheus Oliveira; Liebano, Richard Eloin; Cabral, Cristina Nunes

2017-02-01

To determine whether interferential current (IFC) before Pilates exercises is more effective than placebo in patients with chronic nonspecific low back pain. Two-arm randomized controlled trial, with a blinded assessor, and 6 months follow-up. Clinic of a school of physical therapy. The random sample consisted of patients (N=148) of both sexes, with age between 18 and 80 years and chronic nonspecific low back pain. In addition, participants were recruited by disclosure of the treatment in the media. Patients were allocated into 2 groups: active IFC + Pilates or placebo IFC + Pilates. In the first 2 weeks, patients were treated for 30 minutes with active or placebo IFC. In the following 4 weeks, 40 minutes of Pilates exercises were added after the application of the active or placebo IFC. A total of 18 sessions were offered during 6 weeks. The primary outcome measures were pain intensity, pressure pain threshold, and disability measured at 6 weeks after randomization. No significant differences were found between the groups for pain (0.1 points; 95% confidence interval, -0.9 to 1.0 points), pressure pain threshold (25.3kPa; 95% confidence interval, -4.4 to 55.0kPa), and disability (0.4 points; 95% confidence interval, -1.3 to 2.2). However, there was a significant difference between baseline and 6-week and 6-month follow-ups in the intragroup analysis for all outcomes (P<.05), except pressure pain threshold in the placebo IFC + Pilates group. These findings suggest that active IFC before Pilates exercise is not more effective than placebo IFC with respect to the outcomes assessed in patients with chronic nonspecific low back pain. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Neural correlates of belief-bias reasoning under time pressure: a near-infrared spectroscopy study.

PubMed

Tsujii, Takeo; Watanabe, Shigeru

2010-04-15

The dual-process theory of reasoning explained the belief-bias effect, the tendency for human reasoning to be erroneously biased when logical conclusions are incongruent with belief about the world, by proposing a belief-based fast heuristic system and a logic-based slow analytic system. Although the claims were supported by behavioral findings that the belief-bias effect was enhanced when subjects were not given sufficient time for reasoning, the neural correlates were still unknown. The present study therefore examined the relationship between the time-pressure effect and activity in the inferior frontal cortex (IFC) during belief-bias reasoning using near-infrared spectroscopy (NIRS). Forty-eight subjects performed congruent and incongruent reasoning tasks, involving long-span (20 s) and short-span trials (10 s). Behavioral analysis found that only incongruent reasoning performance was impaired by the time-pressure of short-span trials. NIRS analysis found that the time-pressure decreased right IFC activity during incongruent trials. Correlation analysis showed that subjects with enhanced right IFC activity could perform better in incongruent trials, while subjects for whom the right IFC activity was impaired by the time-pressure could not maintain better reasoning performance. These findings suggest that the right IFC may be responsible for the time-pressure effect in conflicting reasoning processes. When the right IFC activity was impaired in the short-span trials in which subjects were not given sufficient time for reasoning, the subjects may rely on the fast heuristic system, which result in belief-bias responses. We therefore offer the first demonstration of neural correlates of time-pressure effect on the IFC activity in belief-bias reasoning. Copyright 2009 Elsevier Inc. All rights reserved.

Establishing the functional connectivity of the frontotemporal network in pre-attentive change detection with Transcranial Magnetic Stimulation and event-related optical signal.

PubMed

Tse, Chun-Yu; Long-Yin, Yip; Lui, Troby Ka-Yan; Xiao, Xue-Zhen; Wang, Yang; Chu, Winnie Chiu Wing; Parks, Nathan Allen; Chan, Sandra Sau-Man; Neggers, Sebastiaan Franciscus Wijnandus

2018-06-18

Current theories of pre-attentive deviant detection postulate that before the Superior Temporal Cortex (STC) detects a change, the Inferior Frontal Cortex (IFC) engages in stimulus analysis, which is particularly critical for ambiguous deviations (e.g., deviant preceded by a short train of standards). These theories rest on the assumption that IFC and STC are functionally connected, which has only been supported by correlational brain imaging studies. We examined this functional connectivity assumption by applying Transcranial Magnetic Stimulation (TMS) to disrupt IFC function, while measuring the later STC mismatch response with the event-related optical signal (EROS). EROS can localize brain activity in both spatial and temporal dimensions via measurement of optical property changes associated with neuronal activity, and is inert to the electromagnetic interference produced by TMS. Specifically, the STC mismatch response at 120-180 ms elicited by a deviant preceded by a short standard train when IFC TMS was applied at 80 ms was compared with the STC mismatch responses in temporal control (TMS with 200 ms delay), spatial control (sham TMS at vertex), auditory control (TMS pulse noise only), and cognitive control (deviant preceded by a long standard train) conditions. The STC mismatch response to deviants preceded by the short train was abolished by TMS of the IFC at 80 ms, while the STC responses remained intact in all other control conditions. These results confirm the involvement of the IFC in the STC mismatch response and support a functional connection between IFC and STC. Copyright © 2018. Published by Elsevier Inc.

Validation of a New Placebo Interferential Current Method: A New Placebo Method of Electrostimulation.

PubMed

Mendonça Araújo, Fernanda; Alves Menezes, Mayara; Martins de Araújo, Ariane; Abner Dos Santos Sousa, Thiago; Vasconcelos Lima, Lucas; Ádan Nunes Carvalho, Elyson; Melo DeSantana, Josimari

2017-01-01

The present study aimed to investigate if a new placebo device for interferential current (IFC) that delivers current during only the first 40 seconds of stimulation is effective at promoting adequate subject blinding. Seventy-five subjects were recruited and enrolled into three groups: active IFC, inactive placebo, and new placebo. Pressure pain threshold (PPT), cutaneous sensory threshold (CST), and pain intensity were measured before and after the intervention. After the final assessment, the subjects and the investigator who applied the current were asked about the type of stimulation administered. None of the placebo forms studied resulted in significant changes to PPT, CST, or pain intensity. The subjects stimulated with active IFC at high intensities (> 17 mA) of stimulation showed higher PPT and CST and lower pain intensity than subjects stimulated at low intensities ( p < 0.03). The new placebo method blinded the investigator in 100% of cases of IFC and 60% of subjects stimulated, whereas for inactive placebo, the investigator was blinded at a rate of 0% and 34% of subjects. The new method of placebo IFC was effective for blinding of research investigators and most of the active IFC-treated subjects, promoting an appropriate placebo method. © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Ontology for Life-Cycle Modeling of Heating, Ventilating, and Air Conditioning (HVAC) Systems: Experimental Applications Using Revit

DTIC Science & Technology

2012-03-01

Revit object IFCExportType IFCExportAs Radiator Radiator IfcSpaceHeaterType Pump Circulator IfcPumpType Boiler Water IfcBoilerType Fan VaneAxial...modeling is assumed to be a traditional water-based system comprised of boilers and fan coil units (heating) and chillers and air handling units...the properties that a particular engineer would want to specify as part of the BIM model. For instance, the default pump families in Revit do not

Analysis of Cross-Sectional Univariate Measurements for Family Dyads Using Linear Mixed Modeling

PubMed Central

Knafl, George J.; Dixon, Jane K.; O'Malley, Jean P.; Grey, Margaret; Deatrick, Janet A.; Gallo, Agatha M.; Knafl, Kathleen A.

2010-01-01

Outcome measurements from members of the same family are likely correlated. Such intrafamilial correlation (IFC) is an important dimension of the family as a unit but is not always accounted for in analyses of family data. This article demonstrates the use of linear mixed modeling to account for IFC in the important special case of univariate measurements for family dyads collected at a single point in time. Example analyses of data from partnered parents having a child with a chronic condition on their child's adaptation to the condition and on the family's general functioning and management of the condition are provided. Analyses of this kind are reasonably straightforward to generate with popular statistical tools. Thus, it is recommended that IFC be reported as standard practice reflecting the fact that a family dyad is more than just the aggregate of two individuals. Moreover, not accounting for IFC can affect the conclusions. PMID:19307316

Biomechanical evaluation of an integrated fixation cage during fatigue loading: a human cadaver study.

PubMed

Palepu, Vivek; Peck, Jonathan H; Simon, David D; Helgeson, Melvin D; Nagaraja, Srinidhi

2017-04-01

OBJECTIVE Lumbar cages with integrated fixation screws offer a low-profile alternative to a standard cage with anterior supplemental fixation. However, the mechanical stability of integrated fixation cages (IFCs) compared with a cage with anterior plate fixation under fatigue loading has not been investigated. The purpose of this study was to compare the biomechanical stability of a screw-based IFC with a standard cage coupled with that of an anterior plate under fatigue loading. METHODS Eighteen functional spinal units were implanted with either a 4-screw IFC or an anterior plate and cage (AP+C) without integrated fixation. Flexibility testing was conducted in flexion-extension (FE), lateral bending (LB), and axial rotation (AR) on intact spines, immediately after device implantation, and post-fatigue up to 20,000 cycles of FE loading. Stability parameters such as range of motion (ROM) and lax zone (LZ) for each loading mode were compared between the 2 constructs at multiple stages of testing. In addition, construct loosening was quantified by subtracting post-instrumentation ROM from post-fatigue ROM. RESULTS IFC and AP+C configurations exhibited similar stability (ROM and LZ) at every stage of testing in FE (p ≥ 0.33) and LB (p ≥ 0.23) motions. In AR, however, IFCs had decreased ROM compared with AP+C constructs at pre-fatigue (p = 0.07) and at all post-fatigue time points (p ≤ 0.05). LZ followed a trend similar to that of ROM in AR. ROM increased toward intact motion during fatigue cycling for AP+C and IFC implants. IFC specimens remained significantly (p < 0.01) more rigid than specimens in the intact condition during fatigue for each loading mode, whereas AP+C construct motion did not differ significantly (p ≥ 0.37) in FE and LB and was significantly greater (p < 0.01) in AR motion compared with intact specimens after fatigue. Weak to moderate correlations (R 2 ≤ 56%) were observed between T-scores and construct loosening, with lower T-scores leading to decreased stability after fatigue testing. CONCLUSIONS These data indicate that a 4-screw IFC design provides fixation similar to that provided by an AP+C construct in FE and LB during fatigue testing and better stability in AR motion.

Fullerene-like Cs2O nanoparticles generated by concentrated sunlight

NASA Astrophysics Data System (ADS)

Albu-Yaron, Ana; Arad, Talmon; Levy, Moshe; Popovitz-Biro, Ronit; Tenne, Reshef; Gordon, Jeffrey M.; Feuermann, Daniel; Katz, Eugene A.; Jansen, Martin; Mühle, Claus

2006-09-01

We report the rapid high-yield generation of inorganic fullerene-like cesium oxide (IF-Cs2O) nanoparticles, activated by highly concentrated sunlight. The solar process represents an alternative to the only reported method for synthesizing IF-Cs2O nanostructures: laser ablation. IF-Cs2O formed at solar irradiation greater-than or equal to 6W, confirmed by high resolution transmission electron microscopy. These closed-cage Cs2O nanostructures are stable under electron microscope conditions, and also when exposed temporarily to air - of significance for their use in a variety of photonic devices.

BOREAS TGB-10 Oxidant Concentration Data over the SSA

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Westberg, Hal; Hall, Brad; Jackson, Andrea V.

2000-01-01

The BOREAS TGB-10 team collected several trace gas data sets in its efforts to determine the role of biogenic hydrocarbon emissions with respect to boreal forest carbon cycles. This data set contains measured peroxide (H2O2 and total organic peroxides (ROOH)) and ozone concentrations as well as H2O2 and ROOH deposition velocities. These data were obtained at the SSA-OJP site from May to September 1994. The data are stored in tabular ASCII files. Some important results were: (1) Ozone concentrations were consistently low, 20-30 ppb, during the summer of 1994. (2) Peroxide concentrations showed a seasonal variation with highest concentrations occurring in July (IFC-2). (3) Midday H2O2 levels averaged around 1.4 ppb during IFC-2 and 0.4 - 0.5 ppb during IFC's 1 and 3. (4) Midday organic peroxide concentrations were lower, averaging 0.8 ppb during IFC-2, and 0.4 - 0.5 ppb during IFC's 1 and 3. (5) The rough pine forest canopy serves as a significant sink for H2O2. (6) Midday H2O2 deposition velocities averaged 4 - 7 cm/s. (7) Organic peroxide deposition velocities (measured as total ROOH) were approximately 40% as large as those of H2O2.

A novel framework for command and control of networked sensor systems

NASA Astrophysics Data System (ADS)

Chen, Genshe; Tian, Zhi; Shen, Dan; Blasch, Erik; Pham, Khanh

2007-04-01

In this paper, we have proposed a highly innovative advanced command and control framework for sensor networks used for future Integrated Fire Control (IFC). The primary goal is to enable and enhance target detection, validation, and mitigation for future military operations by graphical game theory and advanced knowledge information fusion infrastructures. The problem is approached by representing distributed sensor and weapon systems as generic warfare resources which must be optimized in order to achieve the operational benefits afforded by enabling a system of systems. This paper addresses the importance of achieving a Network Centric Warfare (NCW) foundation of information superiority-shared, accurate, and timely situational awareness upon which advanced automated management aids for IFC can be built. The approach uses the Data Fusion Information Group (DFIG) Fusion hierarchy of Level 0 through Level 4 to fuse the input data into assessments for the enemy target system threats in a battlespace to which military force is being applied. Compact graph models are employed across all levels of the fusion hierarchy to accomplish integrative data fusion and information flow control, as well as cross-layer sensor management. The functional block at each fusion level will have a set of innovative algorithms that not only exploit the corresponding graph model in a computationally efficient manner, but also permit combined functional experiments across levels by virtue of the unifying graphical model approach.

Hyperconnectivity of the Right Posterior Temporo-parietal Junction Predicts Social Difficulties in Boys with Autism Spectrum Disorder.

PubMed

Chien, Hsiang-Yun; Lin, Hsiang-Yuan; Lai, Meng-Chuan; Gau, Susan Shur-Fen; Tseng, Wen-Yih Isaac

2015-08-01

The posterior right temporo-parietal junction (pRTPJ) is a key brain region representing other's mental status. Despite reports of atypical activation at pRTPJ during mentalizing in individuals with autism spectrum disorder (ASD), the intrinsic functional connectivity (iFC) of the pRTPJ remains under-investigated. We examined whether boys with ASD show altered resting-state iFC of the pRTPJ, and whether atypical iFC of the pRTPJ is associated with social deficits in ASD in a sample of 40 boys with high-functioning ASD (aged 9-17 years, mean age, 12.38 ± 2.17; mean IQ, 105.60 ± 16.06) and 42 typically developing (TD) boys (aged 9-17 years, mean age, 11.64 ± 2.71; mean IQ, 111.29 ± 13.45). Both groups received resting-state fMRI assessment after imaging data quality control for in-scanner head motion and spatial coverage. Seed-based approach was used to investigate iFC of the pRTPJ. TD and ASD boys demonstrated a resting-state pRTPJ iFC pattern comparable to the known spatial involvement of the default-mode network. Boys with ASD showed pRTPJ hyperconnectivity relative to TD boys in the right ventral occipito-temporal cortex. This atypically increased iFC in the ASD group was positively correlated with social deficits assessed by the Chinese version of the Autism Diagnostic Interview-Revised and the Social Responsive Scale. Our findings provide empirical support for functional "dysconnectivity," that is, atypical functional integration among brain regions, as an integral component of the atypical neurobiology of ASD. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

BOREAS TGB-10 Oxidant Flux Data over the SSA

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Westberg, Hal; Hall, Brad; Jackson, Andrea V.

2000-01-01

The BOREAS TGB-10 team collected several trace gas data sets in its efforts to determine the role of biogenic hydrocarbon emissions with respect to boreal forest carbon cycles. This oxidant data set contains measured peroxide (H2O2 and total organic peroxides (ROOH)) and ozone concentrations as well as H2O2 and ROOH deposition velocities. These data were obtained at the SSA-OJP site during the summer of 1994. Measurements were made from May to September 1994. The data are stored in tabular ASCII files. Some important results were: (1) Ozone concentrations were consistently low, 20-30 ppb, during the summer of 1994. (2) Peroxide concentrations showed a seasonal variation with highest concentrations occurring in July (IFC-2). (3) Midday H2O2 levels averaged around 1.4 ppb during IFC-2 and 0.4 - 0.5 ppb during IFC's 1 and 3. (4) Midday organic peroxide concentrations were lower, averaging 0.8 ppb during IFC-2, and 0.4 - 0.5 ppb during IFC's 1 and 3. (5) The rough pine forest canopy serves as a significant sink for H2O2. (6) Midday H2O2 deposition velocities averaged 4 - 7 cm/s. (7) Organic peroxide deposition velocities (measured as total ROOH) were approximately 40% as large as those of H2O2.

78 FR 30218 - Pre-Existing Condition Insurance Plan Program

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F-15 IFCS: Intelligent Flight Control System

NASA Technical Reports Server (NTRS)

Bosworth, John

2007-01-01

This viewgraph presentation describes the F-15 Intelligent Flight Control System (IFCS). The goals of this project include: 1) Demonstrate revolutionary control approaches that can efficiently optimize aircraft performance in both normal and failure conditions; and 2) Demonstrate advance neural network-based flight control technology for new aerospace systems designs.

Experiment for Integrating Dutch 3d Spatial Planning and Bim for Checking Building Permits

NASA Astrophysics Data System (ADS)

van Berlo, L.; Dijkmans, T.; Stoter, J.

2013-09-01

This paper presents a research project in The Netherlands in which several SMEs collaborated to create a 3D model of the National spatial planning information. This 2D information system described in the IMRO data standard holds implicit 3D information that can be used to generate an explicit 3D model. The project realized a proof of concept to generate a 3D spatial planning model. The team used the model to integrate it with several 3D Building Information Models (BIMs) described in the open data standard Industry Foundation Classes (IFC). Goal of the project was (1) to generate a 3D BIM model from spatial planning information to be used by the architect during the early design phase, and (2) allow 3D checking of building permits. The team used several technologies like CityGML, BIM clash detection and GeoBIM to explore the potential of this innovation. Within the project a showcase was created with a part of the spatial plan from the city of The Hague. Several BIM models were integrated in the 3D spatial plan of this area. A workflow has been described that demonstrates the benefits of collaboration between the spatial domain and the AEC industry in 3D. The research results in a showcase with conclusions and considerations for both national and international practice.

The loss of imprinted DNA methylation in mouse blastocysts is inflicted to a similar extent by in vitro follicle culture and ovulation induction.

PubMed

Saenz-de-Juano, M D; Billooye, K; Smitz, J; Anckaert, E

2016-06-01

Does in vitro follicle culture (IFC) have an effect on maintenance of imprinted DNA methylation in preimplantation mouse embryos? We report similar alterations in the methylation pattern of H19 imprinted maternally expressed transcript (H19), small nuclear ribonucleoprotein polypeptide N (Snrpn) and mesoderm specific transcript (Mest) imprinted genes in mouse blastocysts obtained after ovulation induction and IFC. Furthermore, we observed no differences in the gene expression of maternal effect proteins related with imprinting maintenance between superovulated in vivo grown or IFC oocytes. Assisted reproductive technology is associated with adverse post-natal outcomes such as increased risk of premature birth, altered birthweight, congenital anomalies and genomic imprinting syndromes in human and in animal models. Previous studies have shown that ovulation induction allowed normal imprinting establishment in mouse oocytes, but interfered with imprinting maintenance during preimplantation . Normal imprinting establishment was also observed in mouse oocytes derived from a standardized IFC from the early pre-antral follicle stage. The methylation profiles of differentially methylated regions (DMRs) of three key imprinted genes (H19, Snrpn and Mest) were compared at hatched blastocyst stage between embryos obtained from IFC or superovulated oocytes, each subjected to IVF and preimplantation in vitro culture (IVC); in non-manipulated in vivo produced late blastocyst (control) and in in vivo produced 2-cell embryos that were in vitro cultured until the hatched blastocyst stage (to assess the effect of IVC). Two different mice strains (Mus musculus C57BL/6J X CBA/Ca and Mus musculus B6 (CAST7)) were used to discriminate between maternal and paternal alleles of imprinted genes. Additionally, a limiting-dilution bisulfite-sequencing technique was carried out on individual embryos in order to avoid amplification bias. To assess whether IFC and ovulation induction differentially affect the mRNA expression of imprinting maintenance genes in the oocyte, a comparison of DNA methyltransferase 1 (Dnmt1o), methyl-CpG binding domain protein 3 (MBD3) and developmental pluripotency-associated 3 (Dppa3) was performed by qPCR between in vivo and in vitro grown oocytes at the germinal vesicle and metaphase II (MII) stage. Results showed a loss of global imprinted DNA methylation in all in vitro manipulated embryos, due to an increase in the amount of abnormal alleles (<50% methylated). Importantly, there were no differences in blastocysts obtained from IFC and ovulation induction. Moreover, similar mRNA expression levels for Dnmt1o, MBD3 and Dppa3 genes were observed in IFC and stimulated oocytes. The methylation analysis was restricted to a number of well-selected imprinted genes. Future studies need to determine whether ovulation induction and IFC affect maternal effect factors at the protein level. In vitro maturation of oocytes (IVM) is a patient-friendly alternative to conventional ovarian stimulation in PCOS patients. IFC is an emerging technology in human oncofertility. The results of this study show for the first time that in vitro oocyte culture induces no additional epigenetic alterations compared with conventional ovulation induction, at least for imprinted genes at the hatched blastocyst stage. The mouse IFC system can be used to test the sensitivity of the oocyte during its growth and maturation to several nutritional, metabolic and hormonal conditions possibly linked to epigenetic alterations. N/A. This study received funding by Strategic Research Programs-Groeiers (OZR/2014/97), IWT/TBM/110680 and by UZ Brussel Fonds Willy Gepts (WFWG 2013). There is no conflict of interest. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

78 FR 61191 - Medicare Program; FY 2014 Inpatient Prospective Payment Systems: Changes to Certain Cost...

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Altered striatal intrinsic functional connectivity in pediatric anxiety

PubMed Central

Dorfman, Julia; Benson, Brenda; Farber, Madeline; Pine, Daniel; Ernst, Monique

2016-01-01

Anxiety disorders are among the most common psychiatric disorders of adolescence. Behavioral and task-based imaging studies implicate altered reward system function, including striatal dysfunction, in adolescent anxiety. However, no study has yet examined alterations of the striatal intrinsic functional connectivity in adolescent anxiety disorders. The current study examines striatal intrinsic functional connectivity (iFC), using six bilateral striatal seeds, among 35 adolescents with anxiety disorders and 36 healthy comparisons. Anxiety is associated with abnormally low iFC within the striatum (e.g., between nucleus accumbens and caudate nucleus), and between the striatum and prefrontal regions, including subgenual anterior cingulate cortex, posterior insula and supplementary motor area. The current findings extend prior behavioral and task-based imaging research, and provide novel data implicating decreased striatal iFC in adolescent anxiety. Alterations of striatal neurocircuitry identified in this study may contribute to the perturbations in the processing of motivational, emotional, interoceptive, and motor information seen in pediatric anxiety disorders. This pattern of the striatal iFC perturbations can guide future research on specific mechanisms underlying anxiety. PMID:27004799

A FUNCTIONAL NEUROIMAGING INVESTIGATION OF THE ROLES OF STRUCTURAL COMPLEXITY AND TASK-DEMAND DURING AUDITORY SENTENCE PROCESSING

PubMed Central

Love, Tracy; Haist, Frank; Nicol, Janet; Swinney, David

2009-01-01

Using functional magnetic resonance imaging (fMRI), this study directly examined an issue that bridges the potential language processing and multi-modal views of the role of Broca’s area: the effects of task-demands in language comprehension studies. We presented syntactically simple and complex sentences for auditory comprehension under three different (differentially complex) task-demand conditions: passive listening, probe verification, and theme judgment. Contrary to many language imaging findings, we found that both simple and complex syntactic structures activated left inferior frontal cortex (L-IFC). Critically, we found activation in these frontal regions increased together with increased task-demands. Specifically, tasks that required greater manipulation and comparison of linguistic material recruited L-IFC more strongly; independent of syntactic structure complexity. We argue that much of the presumed syntactic effects previously found in sentence imaging studies of L-IFC may, among other things, reflect the tasks employed in these studies and that L-IFC is a region underlying mnemonic and other integrative functions, on which much language processing may rely. PMID:16881268

Dynamic reorganization of human resting-state networks during visuospatial attention.

PubMed

Spadone, Sara; Della Penna, Stefania; Sestieri, Carlo; Betti, Viviana; Tosoni, Annalisa; Perrucci, Mauro Gianni; Romani, Gian Luca; Corbetta, Maurizio

2015-06-30

Fundamental problems in neuroscience today are understanding how patterns of ongoing spontaneous activity are modified by task performance and whether/how these intrinsic patterns influence task-evoked activation and behavior. We examined these questions by comparing instantaneous functional connectivity (IFC) and directed functional connectivity (DFC) changes in two networks that are strongly correlated and segregated at rest: the visual (VIS) network and the dorsal attention network (DAN). We measured how IFC and DFC during a visuospatial attention task, which requires dynamic selective rerouting of visual information across hemispheres, changed with respect to rest. During the attention task, the two networks remained relatively segregated, and their general pattern of within-network correlation was maintained. However, attention induced a decrease of correlation in the VIS network and an increase of the DAN→VIS IFC and DFC, especially in a top-down direction. In contrast, within the DAN, IFC was not modified by attention, whereas DFC was enhanced. Importantly, IFC modulations were behaviorally relevant. We conclude that a stable backbone of within-network functional connectivity topography remains in place when transitioning between resting wakefulness and attention selection. However, relative decrease of correlation of ongoing "idling" activity in visual cortex and synchronization between frontoparietal and visual cortex were behaviorally relevant, indicating that modulations of resting activity patterns are important for task performance. Higher order resting connectivity in the DAN was relatively unaffected during attention, potentially indicating a role for simultaneous ongoing activity as a "prior" for attention selection.

Effects of the carrier frequency of interferential current on pain modulation in patients with chronic nonspecific low back pain: a protocol of a randomised controlled trial.

PubMed

Corrêa, Juliana Barbosa; Costa, Leonardo Oliveira Pena; de Oliveira, Naiane Teixeira Bastos; Sluka, Kathleen A; Liebano, Richard Eloin

2013-06-27

Low back pain is an important public health problem that is associated with poor quality of life and disability. Among the electrophysical treatments, interferential current (IFC) has not been studied in patients with low back pain in a high-quality randomised controlled trial examining not only pain, but pain mechanisms and function. A three-arm randomised controlled trial with patient and assessor blinded to the group allocation. One hundred fifty patients with chronic, nonspecific low back pain from outpatient physical therapy clinics in Brazil. The patients will be randomly allocated into 3 groups (IFC 1 kHz, IFC 4 kHz or Placebo IFC). The interferential current will be applied three days per week (30 minutes per session) over four weeks. Pain intensity. The pressure pain threshold, global impression of recovery, disability, function, conditioned pain modulation and temporal summation of pain, discomfort caused by the current. All outcomes will be measured at 4 weeks and 4 months after randomisation. The between-group differences will be calculated by using linear mixed models and Tukey's post-hoc tests. The use of a placebo group and double-blinding assessor and patients strengthen this study. The present study is the first to compare different IFC carrier frequencies in patients with chronic low back pain. Brazilian Registry of Clinical Trials: http://RBR-8n4hg2.

Regional specificity of aberrant thalamocortical connectivity in autism.

PubMed

Nair, Aarti; Carper, Ruth A; Abbott, Angela E; Chen, Colleen P; Solders, Seraphina; Nakutin, Sarah; Datko, Michael C; Fishman, Inna; Müller, Ralph-Axel

2015-11-01

Preliminary evidence suggests aberrant (mostly reduced) thalamocortical (TC) connectivity in autism spectrum disorder (ASD), but despite the crucial role of thalamus in sensorimotor functions and its extensive connectivity with cerebral cortex, relevant evidence remains limited. We performed a comprehensive investigation of region-specific TC connectivity in ASD. Resting-state functional MRI and diffusion tensor imaging (DTI) data were acquired for 60 children and adolescents with ASD (ages 7-17 years) and 45 age, sex, and IQ-matched typically developing (TD) participants. We examined intrinsic functional connectivity (iFC) and anatomical connectivity (probabilistic tractography) with thalamus, using 68 unilateral cerebral cortical regions of interest (ROIs). For frontal and parietal lobes, iFC was atypically reduced in the ASD group for supramodal association cortices, but was increased for cingulate gyri and motor cortex. Temporal iFC was characterized by overconnectivity for auditory cortices, but underconnectivity for amygdalae. Occipital iFC was broadly reduced in the ASD group. DTI indices (such as increased radial diffusion) for regions with group differences in iFC further indicated compromised anatomical connectivity, especially for frontal ROIs, in the ASD group. Our findings highlight the regional specificity of aberrant TC connectivity in ASD. Their overall pattern can be largely accounted for by functional overconnectivity with limbic and sensorimotor regions, but underconnectivity with supramodal association cortices. This could be related to comparatively early maturation of limbic and sensorimotor regions in the context of early overgrowth in ASD, at the expense of TC connectivity with later maturing cortical regions. © 2015 Wiley Periodicals, Inc.

Unlearning chronic pain: A randomized controlled trial to investigate changes in intrinsic brain connectivity following Cognitive Behavioral Therapy

PubMed Central

Shpaner, Marina; Kelly, Clare; Lieberman, Greg; Perelman, Hayley; Davis, Marcia; Keefe, Francis J.; Naylor, Magdalena R.

2014-01-01

Chronic pain is a complex physiological and psychological phenomenon. Implicit learning mechanisms contribute to the development of chronic pain and to persistent changes in the central nervous system. We hypothesized that these central abnormalities can be remedied with Cognitive Behavioral Therapy (CBT). Specifically, since regions of the anterior Default Mode Network (DMN) are centrally involved in emotional regulation via connections with limbic regions, such as the amygdala, remediation of maladaptive behavioral and cognitive patterns as a result of CBT for chronic pain would manifest itself as a change in the intrinsic functional connectivity (iFC) between these prefrontal and limbic regions. Resting-state functional neuroimaging was performed in patients with chronic pain before and after 11-week CBT (n = 19), as well as a matched (ages 19–59, both sexes) active control group of patients who received educational materials (n = 19). Participants were randomized prior to the intervention. To investigate the differential impact of treatment on intrinsic functional connectivity (iFC), we compared pre–post differences in iFC between groups. In addition, we performed exploratory whole brain analyses of changes in fractional amplitude of low frequency fluctuations (fALFF). The course of CBT led to significant improvements in clinical measures of pain and self-efficacy for coping with chronic pain. Significant group differences in pre–post changes in both iFC and fALFF were correlated with clinical outcomes. Compared to control patients, iFC between the anterior DMN and the amygdala/periaqueductal gray decreased following CBT, whereas iFC between the basal ganglia network and the right secondary somatosensory cortex increased following CBT. CBT patients also had increased post-therapy fALFF in the bilateral posterior cingulate and the cerebellum. By delineating neuroplasticity associated with CBT-related improvements, these results add to mounting evidence that CBT is a valuable treatment option for chronic pain. PMID:26958466

Cortical Signatures of Dyslexia and Remediation: An Intrinsic Functional Connectivity Approach

PubMed Central

Koyama, Maki S.; Di Martino, Adriana; Kelly, Clare; Jutagir, Devika R.; Sunshine, Jessica; Schwartz, Susan J.; Castellanos, Francisco X.; Milham, Michael P.

2013-01-01

This observational, cross-sectional study investigates cortical signatures of developmental dyslexia, particularly from the perspective of behavioral remediation. We employed resting-state fMRI, and compared intrinsic functional connectivity (iFC) patterns of known reading regions (seeds) among three dyslexia groups characterized by (a) no remediation (current reading and spelling deficits), (b) partial remediation (only reading deficit remediated), and (c) full remediation (both reading and spelling deficits remediated), and a group of age- and IQ-matched typically developing children (TDC) (total N = 44, age range = 7–15 years). We observed significant group differences in iFC of two seeds located in the left posterior reading network – left intraparietal sulcus (L.IPS) and left fusiform gyrus (L.FFG). Specifically, iFC between L.IPS and left middle frontal gyrus was significantly weaker in all dyslexia groups, irrespective of remediation status/literacy competence, suggesting that persistent dysfunction in the fronto-parietal attention network characterizes dyslexia. Additionally, relative to both TDC and the no remediation group, the remediation groups exhibited stronger iFC between L.FFG and right middle occipital gyrus (R.MOG). The full remediation group also exhibited stronger negative iFC between the same L.FFG seed and right medial prefrontal cortex (R.MPFC), a core region of the default network These results suggest that behavioral remediation may be associated with compensatory changes anchored in L.FFG, which reflect atypically stronger coupling between posterior visual regions (L.FFG-R.MOG) and greater functional segregation between task-positive and task-negative regions (L.FFG-R.MPFC). These findings were bolstered by significant relationships between the strength of the identified functional connections and literacy scores. We conclude that examining iFC can reveal cortical signatures of dyslexia with particular promise for monitoring neural changes associated with behavioral remediation. PMID:23408984

To rise and to fall: functional connectivity in cognitively normal and cognitively impaired patients with Parkinson's disease.

PubMed

Gorges, Martin; Müller, Hans-Peter; Lulé, Dorothée; Pinkhardt, Elmar H; Ludolph, Albert C; Kassubek, Jan

2015-04-01

Cognitive decline is a burdensome extra-motor symptom associated with Parkinson's disease (PD). This study aimed at investigating intrinsic functional connectivity (iFC) of the brain in cognitively unimpaired (PD-CU) and impaired PD patients (PD-CI) compared with age-matched healthy controls. "Resting-state" functional magnetic resonance imaging was acquired in 53 subjects, that is, 14 PD-CU patients, 17 PD-CI patients, and 22 control subjects. Cognition and cognitive status for patient classification were assessed using detailed neuropsychological testing. In PD-CU patients versus controls, we demonstrated significantly increased iFC (hyperconnectivity) presenting as network expansions in cortical, limbic, and basal ganglia-thalamic areas. Significantly, decreased iFC in PD-CI patients compared with control subjects was observed, predominantly between major nodes of the default mode network. In conclusion, the increased iFC might be the initial manifestation of altered brain function preceding cognitive deficits. Hyperconnectivity could be an adaptive (compensatory) mechanism by recruiting additional resources to maintain normal cognitive performance. As PD-related pathology progresses, functional disruptions within the default mode networks seem to be considerably associated with cognitive decline. Copyright © 2015 Elsevier Inc. All rights reserved.

Transcranial direct current stimulation (tDCS) of the inferior frontal cortex affects the "social scaling" of extrapersonal space depending on perspective-taking ability.

PubMed

Fini, Chiara; Bardi, Lara; Epifanio, Alessandra; Committeri, Giorgia; Moors, Agnes; Brass, Marcel

2017-03-01

When we have to judge the distance between another person and an object (social condition), we judge this distance as being smaller compared to judging the distance between two objects (nonsocial condition). It has been suggested that this compression is mediated by the attribution of a motor potential to the reference frame (other person vs. object). In order to explore the neural basis of this effect, we investigated whether the modulation of activity in the inferior frontal cortex (IFC) of the left hemisphere (recruited during visuospatial processes with a social component) changes the way we categorize space in a social compared with a nonsocial condition. We applied transcranial direct current stimulation to the left IFC, with different polarities (anodal, cathodal, and sham) while subjects performed an extrapersonal space categorization task. Interestingly, anodal stimulation of IFC induced an higher compression of space in the social compared to nonsocial condition. By contrast, cathodal stimulation induced the opposite effect. Furthermore, we found that this effect is modulated by interindividual differences in cognitive perspective taking. Our data support the idea that IFC is recruited during the social categorization of space.

Flight Test of an Intelligent Flight-Control System

NASA Technical Reports Server (NTRS)

Davidson, Ron; Bosworth, John T.; Jacobson, Steven R.; Thomson, Michael Pl; Jorgensen, Charles C.

2003-01-01

The F-15 Advanced Controls Technology for Integrated Vehicles (ACTIVE) airplane (see figure) was the test bed for a flight test of an intelligent flight control system (IFCS). This IFCS utilizes a neural network to determine critical stability and control derivatives for a control law, the real-time gains of which are computed by an algorithm that solves the Riccati equation. These derivatives are also used to identify the parameters of a dynamic model of the airplane. The model is used in a model-following portion of the control law, in order to provide specific vehicle handling characteristics. The flight test of the IFCS marks the initiation of the Intelligent Flight Control System Advanced Concept Program (IFCS ACP), which is a collaboration between NASA and Boeing Phantom Works. The goals of the IFCS ACP are to (1) develop the concept of a flight-control system that uses neural-network technology to identify aircraft characteristics to provide optimal aircraft performance, (2) develop a self-training neural network to update estimates of aircraft properties in flight, and (3) demonstrate the aforementioned concepts on the F-15 ACTIVE airplane in flight. The activities of the initial IFCS ACP were divided into three Phases, each devoted to the attainment of a different objective. The objective of Phase I was to develop a pre-trained neural network to store and recall the wind-tunnel-based stability and control derivatives of the vehicle. The objective of Phase II was to develop a neural network that can learn how to adjust the stability and control derivatives to account for failures or modeling deficiencies. The objective of Phase III was to develop a flight control system that uses the neural network outputs as a basis for controlling the aircraft. The flight test of the IFCS was performed in stages. In the first stage, the Phase I version of the pre-trained neural network was flown in a passive mode. The neural network software was running using flight data inputs with the outputs provided to instrumentation only. The IFCS was not used to control the airplane. In another stage of the flight test, the Phase I pre-trained neural network was integrated into a Phase III version of the flight control system. The Phase I pretrained neural network provided realtime stability and control derivatives to a Phase III controller that was based on a stochastic optimal feedforward and feedback technique (SOFFT). This combined Phase I/III system was operated together with the research flight-control system (RFCS) of the F-15 ACTIVE during the flight test. The RFCS enables the pilot to switch quickly from the experimental- research flight mode back to the safe conventional mode. These initial IFCS ACP flight tests were completed in April 1999. The Phase I/III flight test milestone was to demonstrate, across a range of subsonic and supersonic flight conditions, that the pre-trained neural network could be used to supply real-time aerodynamic stability and control derivatives to the closed-loop optimal SOFFT flight controller. Additional objectives attained in the flight test included (1) flight qualification of a neural-network-based control system; (2) the use of a combined neural-network/closed-loop optimal flight-control system to obtain level-one handling qualities; and (3) demonstration, through variation of control gains, that different handling qualities can be achieved by setting new target parameters. In addition, data for the Phase-II (on-line-learning) neural network were collected, during the use of stacked-frequency- sweep excitation, for post-flight analysis. Initial analysis of these data showed the potential for future flight tests that will incorporate the real-time identification and on-line learning aspects of the IFCS.

Role of different lymphocyte subpopulations in the formation of non-specific immunoglobulins induced by antigen injection.

PubMed

Chernyshova, I N; Borisova, T K; Emelyanzeva, J A; Sidorova, E V

1999-04-01

The formation of antibody and non-specific immunoglobulin under the influence of T-dependent (TD) and type 2 T-independent (TI-2) antigens in mice of two congenic strains CBA (Lyb5-, Lyb5+) and CBA/N (Lyb5-) was studied. TD antigens induced in mice of both strains not only the appearance of antibody-forming cells (AFC), but also a great increase in the number of cells producing non-specific immunoglobulins (nIFC). TI-2 antigens induced the AFC and antigen-dependent nIFC formation in CBA mice only. It is concluded that during immune response to TI-2 antigens not only the AFC appearance but the increase in nIFC formation (polyclonal activation) is due mainly to the mature Lyb5+ B cells.

The Intelligent Flight Control Program (IFCS)

NASA Technical Reports Server (NTRS)

2003-01-01

Institute for Scientific Research, Inc. (ISR) is pleased to submit this closeout report for the Research Cooperative Agreement NCC4-00128 of accomplishments for the Intelligent Flight Control System (IFCS) Project. It has been a pleasure working with NASA and NASA partners as we strive to meet the goals of this research initiative. ISR was engaged in this Research Cooperative Agreement beginning March 3, 2001 and ending March 31, 2003. During this time, a great deal has been accomplished and plans have been solidified for the continued success of this program. Our primary areas of involvement include the following: 1) ARTS II Master Test Plan; 2) ARTS II Hardware Design and Development; 3) ARTS II Software Design and Development; 4) IFCS PID/BLNN/OLNN Development; 5) Performed Preliminary and Formal Testing; 6) Documentation and Reporting.

Simulations of the WFIRST Supernova Survey and Forecasts of Cosmological Constraints

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hounsell, R.; Scolnic, D.; Foley, R. J.

The Wide Field InfraRed Survey Telescope (WFIRST) was the highest rankedlarge space-based mission of the 2010 New Worlds, New Horizons decadal survey.It is now a NASA mission in formulation with a planned launch in themid-2020's. A primary mission objective is to precisely constrain the nature ofdark energy through multiple probes, including Type Ia supernovae (SNe Ia).Here, we present the first realistic simulations of the WFIRST SN survey basedon current hardware specifications and using open-source tools. We simulate SNlight curves and spectra as viewed by the WFIRST wide-field channel (WFC)imager and integral field channel (IFC) spectrometer, respectively. We examine11 survey strategiesmore » with different time allocations between the WFC and IFC,two of which are based upon the strategy described by the WFIRST ScienceDefinition Team, which measures SN distances exclusively from IFC data. Wepropagate statistical and, crucially, systematic uncertainties to predict thedark energy task force figure of merit (DETF FoM) for each strategy. Theincrease in FoM values with SN search area is limited by the overhead times foreach exposure. For IFC-focused strategies the largest individual systematicuncertainty is the wavelength-dependent calibration uncertainty, whereas forWFC-focused strategies, it is the intrinsic scatter uncertainty. We find thatthe best IFC-focused and WFC-exclusive strategies have comparable FoM values.Even without improvements to other cosmological probes, the WFIRST SN surveyhas the potential to increase the FoM by more than an order of magnitude fromthe current values. Although the survey strategies presented here have not beenfully optimized, these initial investigations are an important step in thedevelopment of the final hardware design and implementation of the WFIRSTmission.« less

Anharmonic interatomic force constants and thermal conductivity from Grüneisen parameters: An application to graphene

NASA Astrophysics Data System (ADS)

Lee, Ching Hua; Gan, Chee Kwan

2017-07-01

Phonon-mediated thermal conductivity, which is of great technological relevance, arises due fundamentally to anharmonic scattering from interatomic potentials. Despite its prevalence, accurate first-principles calculations of thermal conductivity remain challenging, primarily due to the high computational cost of anharmonic interatomic force constant (IFC) calculations. Meanwhile, the related anharmonic phenomenon of thermal expansion is much more tractable, being computable from the Grüneisen parameters associated with phonon frequency shifts due to crystal deformations. In this work, we propose an approach for computing the largest cubic IFCs from the Grüneisen parameter data. This allows an approximate determination of the thermal conductivity via a much less expensive route. The key insight is that although the Grüneisen parameters cannot possibly contain all the information on the cubic IFCs, being derivable from spatially uniform deformations, they can still unambiguously and accurately determine the largest and most physically relevant ones. By fitting the anisotropic Grüneisen parameter data along judiciously designed deformations, we can deduce (i.e., reverse-engineer) the dominant cubic IFCs and estimate three-phonon scattering amplitudes. We illustrate our approach by explicitly computing the largest cubic IFCs and thermal conductivity of graphene, especially for its out-of-plane (flexural) modes that exhibit anomalously large anharmonic shifts and thermal conductivity contributions. Our calculations on graphene not only exhibit reasonable agreement with established density-functional theory results, but they also present a pedagogical opportunity for introducing an elegant analytic treatment of the Grüneisen parameters of generic two-band models. Our approach can be readily extended to more complicated crystalline materials with nontrivial anharmonic lattice effects.

Anatomically related gray and white matter alterations in the brains of functional dyspepsia patients.

PubMed

Nan, J; Liu, J; Mu, J; Zhang, Y; Zhang, M; Tian, J; Liang, F; Zeng, F

2015-06-01

Previous studies summarized altered brain functional patterns in functional dyspepsia (FD) patients, but how the brain structural patterns are related to FD remains largely unclear. The objective of this study was to determine the brain structural characteristics in FD patients. Optimized voxel-based morphometry and tract-based spatial statistics were employed to investigate the changes in gray matter (GM) and white matter (WM) respectively in 34 FD patients with postprandial distress syndrome and 33 healthy controls based on T1-weighted and diffusion-weighted imaging. The Pearson's correlation evaluated the link among GM alterations, WM abnormalities, and clinical variables in FD patients. The optimal brain structural parameters for identifying FD were explored using the receiver operating characteristic curve. Compared to controls, FD patients exhibited a decrease in GM density (GMD) in the right posterior insula/temporal superior cortex (marked as pINS), right inferior frontal cortex (IFC), and left middle cingulate cortex, and an increase in fractional anisotropy (FA) in the posterior limb of the internal capsule, posterior thalamic radiation, and external capsule (EC). Interestingly, the GMD in the pINS was significantly associated with GMD in the IFC and FA in the EC. Moreover, the EC adjacent to the pINS provided the best performance for distinguishing FD patients from controls. Our results showed pINS-related structural abnormalities in FD patients, indicating that GM and WM parameters were not affected independently. These findings would lay the foundation for probing an efficient target in the brain for treating FD. © 2015 John Wiley & Sons Ltd.

F-15 837 IFCS Intelligent Flight Control System Project

NASA Technical Reports Server (NTRS)

Bosworth, John T.

2007-01-01

This viewgraph presentation reviews the use of Intelligent Flight Control System (IFCS) for the F-15. The goals of the project are: (1) Demonstrate Revolutionary Control Approaches that can Efficiently Optimize Aircraft Performance in both Normal and Failure Conditions (2) Advance Neural Network-Based Flight Control Technology for New Aerospace Systems Designs. The motivation for the development are to reduce the chance and skill required for survival.

[Comparison of the analgesic effect of interferential current (IFC) and TENS in patients with low back pain].

PubMed

Grabiańska, Ewa; Leśniewicz, Joanna; Pieszyński, Ireneusz; Kostka, Joanna

2015-01-01

Electrotherapy, including theTENS and interferential current (IFC) is one of the most frequently used treatments in physical therapy in patients with low back pain. The aim of this study was to assess the influence of TENS and IFC on pain relief and to compare the analgesic efficacy of the two currents. Sixty patients aged 53.5 ± 12.5, with low back pain, were randomly divided into two groups: IFC (gr. I) and TENS (gr. II). Depending on the groups, patients were given series of ten 20-minute sessions using either IF orTENS currents. In all patients VAS and Laitinen modified scale were taken before and after treatment. After 2-weeks therapy there was improvement in the VAS and Laitinen scale (all components) in both groups, except for the part of the Laitinen scale on the reduction of activity in the group II (TENS). There was no statistically significant difference between the TENS and IF groups in reducing the intensity and other aspects of pain (frequency, pain medication and activity limitation) under the influence of therapy (p > 0.05). Interferential current and TENS therapy are effective for pain relief in patients with low back pain. The study showed equal analgesic efficacy of both treatments.

Task-dependent and distinct roles of the temporoparietal junction and inferior frontal cortex in the control of imitation

PubMed Central

Obhi, Sukhvinder S.; Banissy, Michael J.; Santiesteban, Idalmis; Press, Clare; Catmur, Caroline; Bird, Geoffrey

2015-01-01

The control of neurological networks supporting social cognition is crucially important for social interaction. In particular, the control of imitation is directly linked to interaction quality, with impairments associated with disorders characterized by social difficulties. Previous work suggests inferior frontal cortex (IFC) and the temporoparietal junction (TPJ) are involved in controlling imitation, but the functional roles of these areas remain unclear. Here, transcranial direct current stimulation (tDCS) was used to enhance cortical excitability at IFC and the TPJ prior to the completion of three tasks: (i) a naturalistic social interaction during which increased imitation is known to improve rapport, (ii) a choice reaction time task in which imitation needs to be inhibited for successful performance and (iii) a non-imitative control task. Relative to sham stimulation, stimulating IFC improved the context-dependent control of imitation—participants imitated more during the social interaction and less during the imitation inhibition task. In contrast, stimulating the TPJ reduced imitation in the inhibition task without affecting imitation during social interaction. Neither stimulation site affected the non-imitative control task. These data support a model in which IFC modulates imitation directly according to task demands, whereas TPJ controls task-appropriate shifts in attention toward representation of the self or the other, indirectly impacting upon imitation. PMID:25481003

BOREAS TE-8 Aspen Bark Spectral Reflectance Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Papagno, Andrea (Editor); Spencer, Shannon L.; Rock, Barrett N.

2000-01-01

The BOREAS TE-08 team collected in-lab spectral reflectance data for aspen bark and leaves from three sites within the BOREAS SSA from 24-May-1994 to 16-Jun-1994 (IFC 1), 19-Jul-1994 to 08-Aug-1994 (IFC 2), and 30-Aug-1994 to 19-Sep-1994 (IFC 3). One to nine trees from each site were sampled during the three IFCs. Each tree was sampled in five different locations for bark spectral properties: BS, US, BR, BT, and BO. Additionally, a limited number of LV were collected. Bark samples were removed from the stem of the tree and placed in ziplock bags for transport to UNH, where they were scanned with a spectroradiometer in a controlled environment. Each sample was scanned twice: the first set of measurements was made with the bark surface moistened, and the second set was made with the bark surface air-dried for a period of 30 minutes. These data represent continuous spectra of bark reflectance. Each sample was scanned three times, rotating the sample when possible. The reported values for each sample are an average over the three scans. The data are provided in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Lessons Learned and Flight Results from the F15 Intelligent Flight Control System Project

NASA Technical Reports Server (NTRS)

Bosworth, John

2006-01-01

A viewgraph presentation on the lessons learned and flight results from the F15 Intelligent Flight Control System (IFCS) project is shown. The topics include: 1) F-15 IFCS Project Goals; 2) Motivation; 3) IFCS Approach; 4) NASA F-15 #837 Aircraft Description; 5) Flight Envelope; 6) Limited Authority System; 7) NN Floating Limiter; 8) Flight Experiment; 9) Adaptation Goals; 10) Handling Qualities Performance Metric; 11) Project Phases; 12) Indirect Adaptive Control Architecture; 13) Indirect Adaptive Experience and Lessons Learned; 14) Gen II Direct Adaptive Control Architecture; 15) Current Status; 16) Effect of Canard Multiplier; 17) Simulated Canard Failure Stab Open Loop; 18) Canard Multiplier Effect Closed Loop Freq. Resp.; 19) Simulated Canard Failure Stab Open Loop with Adaptation; 20) Canard Multiplier Effect Closed Loop with Adaptation; 21) Gen 2 NN Wts from Simulation; 22) Direct Adaptive Experience and Lessons Learned; and 23) Conclusions

Mammalian Vestibular Macular Synaptic Plasticity: Results from SLS-2 Spaceflight

NASA Technical Reports Server (NTRS)

Ross, Muriel D.D.

1994-01-01

The effects of exposure to microgravity were studied in rat utricular maculas collected inflight (IF, day 13), post-flight on day of orbiter landing (day 14, R+O) and after 14 days (R+ML). Controls were collected at corresponding times. The objectives were 1) to learn whether hair cell ribbon synapses counts would be higher in tissues collected in space than in tissues collected postflight during or after readaptation to Earth's gravity; and 2) to compare results with those of SLS-1. Maculas were fixed by immersion, micro-dissected, dehydrated and prepared for ultrastructural study by usual methods. Synapses were counted in 100 serial sections 150 nm thick and were located to specific hair cells in montages of every 7th section. Counts were analyzed for statistical significance using analysis of variance. Results in maculas of IF dissected rats, one 13 day control (IFC), and one R + 0 rat have been analyzed. Study of an R+ML macula is nearly completed. For type I cells, IF mean is 2.3 +/-1.6; IFC mean is 1.6 +/-1.0; R+O mean is 2.3 +/- 1.6. For type II cells, IF mean is 11.4 +/- 17.1; IFC mean is 5.5 +/-3.5; R+O mean is 10.1 +/- 7.4. The difference between IF and IFC means for type I cells is statistically significant (p less than 0.0464). For type It cells, IF compared to IFC means, p less than 0.0003; and for IFC to R+O means, p less than 0.0139. Shifts toward spheres (p less than 0.0001) and pairs (p less than 0.0139) were significant in type II cells of IF rats. The results are largely replicating findings from SLS-1 and indicate that spaceflight affects synaptic number, form and distribution, particularly in type II hair cells. The increases in synaptic number and in sphere-like ribbons are interpreted to improve synaptic efficacy, to help return afferent discharges to a more normal state. Findings indicate that a great capacity for synaptic plasticity exists in mammalian gravity sensors, and that this plasticity is more dominant in the local circuitry. The local circuit includes type II cells and is interpreted to be responsible for shaping the final output of the system.

Task-dependent and distinct roles of the temporoparietal junction and inferior frontal cortex in the control of imitation.

PubMed

Hogeveen, Jeremy; Obhi, Sukhvinder S; Banissy, Michael J; Santiesteban, Idalmis; Press, Clare; Catmur, Caroline; Bird, Geoffrey

2015-07-01

The control of neurological networks supporting social cognition is crucially important for social interaction. In particular, the control of imitation is directly linked to interaction quality, with impairments associated with disorders characterized by social difficulties. Previous work suggests inferior frontal cortex (IFC) and the temporoparietal junction (TPJ) are involved in controlling imitation, but the functional roles of these areas remain unclear. Here, transcranial direct current stimulation (tDCS) was used to enhance cortical excitability at IFC and the TPJ prior to the completion of three tasks: (i) a naturalistic social interaction during which increased imitation is known to improve rapport, (ii) a choice reaction time task in which imitation needs to be inhibited for successful performance and (iii) a non-imitative control task. Relative to sham stimulation, stimulating IFC improved the context-dependent control of imitation-participants imitated more during the social interaction and less during the imitation inhibition task. In contrast, stimulating the TPJ reduced imitation in the inhibition task without affecting imitation during social interaction. Neither stimulation site affected the non-imitative control task. These data support a model in which IFC modulates imitation directly according to task demands, whereas TPJ controls task-appropriate shifts in attention toward representation of the self or the other, indirectly impacting upon imitation. © The Author (2014). Published by Oxford University Press.

Inter-hemispheric Intrinsic Connectivity as a Neuromarker for the Diagnosis of Boys with Tourette Syndrome.

PubMed

Liao, Wei; Yu, Yang; Miao, Huan-Huan; Feng, Yi-Xuan; Ji, Gong-Jun; Feng, Jian-Hua

2017-05-01

Tourette syndrome (TS) is associated with gross morphological changes in the corpus callosum, suggesting deficits in inter-hemispheric coordination. The present study sought to identify changes in inter-hemispheric functional and anatomical connectivity in boys with "pure" TS as well as their potential value for clinical diagnosis. TS boys without comorbidity (pure TS, n = 24) were selected from a large dataset and compared to age- and education-matched controls (n = 32). Intrinsic functional connectivity (iFC) between bilateral homotopic voxels was computed and compared between groups. Abnormal iFC was found in the bilateral prefronto-striatum-midbrain networks as well as bilateral sensorimotor and temporal cortices. The iFC between the bilateral anterior cingulate cortex (ACC) was negatively correlated with symptom severity. Anatomical connectivity strengths between functionally abnormal regions were estimated by diffusion probabilistic tractography, but no significant between-group difference was found. To test the clinical applicability of these neuroimaging findings, multivariate pattern analysis was used to develop a classification model in half of the total sample. The classification model exhibited excellent classification power for discriminating TS patients from controls in the other half samples. In summary, our findings emphasize the role of inter-hemispheric communication deficits in the pathophysiology of TS and suggest that iFC is a potential quantitative neuromarker for clinical diagnosis.

Effects of High-Definition and Conventional tDCS on Response Inhibition.

PubMed

Hogeveen, J; Grafman, J; Aboseria, M; David, A; Bikson, M; Hauner, K K

2016-01-01

Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task. Copyright © 2016 Elsevier Inc. All rights reserved.

Meta-analysis of transcutaneous electrical nerve stimulation for relief of spinal pain.

PubMed

Resende, L; Merriwether, E; Rampazo, É P; Dailey, D; Embree, J; Deberg, J; Liebano, R E; Sluka, K A

2018-04-01

We conducted a systematic review and meta-analysis analysing the existing data on transcutaneous electrical nerve stimulation (TENS) or interferential current (IFC) for chronic low back pain (CLBP) and/or neck pain (CNP) taking into account intensity and timing of stimulation, examining pain, function and disability. Seven electronic databases were searched for TENS or IFC treatment in non-specific CLBP or CNP. Four reviewers independently selected randomized controlled trials (RCTs) of TENS or IFC intervention in adult individuals with non-specific CLBP or CNP. Primary outcomes were for self-reported pain intensity and back-specific disability. Two reviewers performed quality assessment, and two reviewers extracted data using a standardized form. Nine RCTs were selected (eight CLBP; one CNP), and seven studies with complete data sets were included for meta-analysis (655 participants). For CLBP, meta-analysis shows TENS/IFC intervention, independent of time of assessment, was significantly different from placebo/control (p < 0.02). TENS/IFC intervention was better than placebo/control, during therapy (p = 0.02), but not immediately after therapy (p = 0.08), or 1-3 months after therapy (p = 0.99). Analysis for adequate stimulation parameters was not significantly different, and there was no effect on disability. This systematic review provides inconclusive evidence of TENS benefits in low back pain patients because the quality of the studies was low, and adequate parameters and timing of assessment were not uniformly used or reported. Without additional high-quality clinical trials using sufficient sample sizes and adequate parameters and outcome assessments, the outcomes of this review are likely to remain unchanged. These data highlight the need for additional high-quality RCTs to examine the effects of TENS in CLBP. Trials should consider intensity of stimulation, timing of outcome assessment and assessment of pain, disability and function. © 2017 European Pain Federation - EFIC®.

Comparative Modeling Studies of Boreal Water and Carbon Balance

NASA Technical Reports Server (NTRS)

Coughlan, J.; Peterson, David L. (Technical Monitor)

1997-01-01

The coordination of the modeling and field efforts for an Intensive Field Campaign (IFC) may resemble the chicken and egg dilemma. This session's theme advocates that early and proactive involvement by modeling teams can produce a scientific and operational benefit for the IFC and Experiment. This talk will provide some examples and suggestions originating from the NASA funded IFC's of the FIFE First ISLSCP (International Satellite Land Surface Climatology Project) Field Experiment, Oregon Transect Ecosystem Research (OTTER) and predominately Boreal Ecosystem-Atmosphere Study (BOREAS) Experiments. In February 1994 and prior to the final selection of the BOREAS study sites, a group of funded BOREAS investigators agreed to run their models with data for five community types representing the proposed tower flux sites. All participating models were given identical initial values and boundary conditions and driven with identical climate data. The objectives of the intercomparison exercise were: 1) compare simulation results of participating terrestrial, hydrological, and atmospheric models over selected time frames; 2) learn about model behavior and sensitivity to estimated boreal site and vegetation definitions; 3) prioritize BOREAS field data collection efforts supporting modeling studies; 4) identify individual model deficiencies as early as possible. Out of these objectives evolved some important coordination and science issues for the BOREAS Experiment that can be generalized to IFCs and long term archiving of the data. Some problems are acceptable because they are endemic to maintaining fair and open competition prior to the peer review process. Others are logistical and addressable through application of planning, management, and information sciences. This investigator has identified one source of measurement and model incompatibility that is manifest in the IFC scaling approach. Although intuitively obvious, scaling problems are already more formally defined in the Geography literature. An example of the scaling problem will be demonstrated with Vegetation/Ecosystem Mapping and Analysis Project (VEMAP) and OTTER data.

Addressing Control Research Issues Leading to Piloted Simulations in Support of the IFCS F-15

NASA Technical Reports Server (NTRS)

Napolitano, Marcello; Perhinschi, Mario; Campa, Giampiero; Seanor, Brad

2004-01-01

This report summarizes the research effort by a team of researchers at West Virginia University in support of the NASA Intelligent Flight Control System (IFCS) F-15 program. In particular, WVU researchers assisted NASA Dryden researchers in the following technical tasks leading to piloted simulation of the 'Gen_2' IFCS control laws. Task #1- Performance comparison of different neural network (NN) augmentation for the Dynamic Inversion (DI) -based VCAS 'Gen_2' control laws. Task #2- Development of safety monitor criteria for transition to research control laws with and without failure during flight test. Task #3- Fine-tuning of the 'Gen_2' control laws for cross-coupling reduction at post-failure conditions. Matlab/Simulink-based simulation codes were provided to the technical monitor on a regular basis throughout the duration of the project. Additional deliverables for the project were Power Point-based slides prepared for different project meetings. This document provides a description of the methodology and discusses the general conclusions from the simulation results.

BOREAS RSS-18 Level-1B AVIRIS Imagery: At-Sensor Radiance in BIL Format

NASA Technical Reports Server (NTRS)

Newcomer, Jeffrey A.; Hall, Forrest G. (Editor); Nickerson, Jaime (Editor); Green, Robert O.; Smith, David E. (Technical Monitor)

2000-01-01

These data were collected and processed by the BOREAS RSS-18 team at NASA JPL. Data were acquired for BOREAS with NASA's AVIRIS. This optical sensor measures images that consist of spectra from 400 to 2500 nm at 10-nm sampling. These spectra are acquired as images with 20-meter spatial resolution, 11-km swath width and up to 800-km length. The measurements are spectrally, radiometrically, and geometrically calibrated. Spatially, the data are focused on the BOREAS NSA and SSA near Thompson, Manitoba, and Candle Lake, Saskatchewan, Canada, respectively. AVIRIS data were collected in 1994 during the Thaw campaign at the NSA and SSA, at the SSA in IFC-1, and at the NSA and SSA in both IFC-2 and IFC-3. In 1996, AVIRIS was deployed in the winter and summer campaigns in the SSA only. The data files are available on a CD-ROM (see document number 20010000884) or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Development and Flight Testing of a Neural Network Based Flight Control System on the NF-15B Aircraft

NASA Technical Reports Server (NTRS)

Bomben, Craig R.; Smolka, James W.; Bosworth, John T.; Silliams-Hayes, Peggy S.; Burken, John J.; Larson, Richard R.; Buschbacher, Mark J.; Maliska, Heather A.

2006-01-01

The Intelligent Flight Control System (IFCS) project at the NASA Dryden Flight Research Center, Edwards AFB, CA, has been investigating the use of neural network based adaptive control on a unique NF-15B test aircraft. The IFCS neural network is a software processor that stores measured aircraft response information to dynamically alter flight control gains. In 2006, the neural network was engaged and allowed to learn in real time to dynamically alter the aircraft handling qualities characteristics in the presence of actual aerodynamic failure conditions injected into the aircraft through the flight control system. The use of neural network and similar adaptive technologies in the design of highly fault and damage tolerant flight control systems shows promise in making future aircraft far more survivable than current technology allows. This paper will present the results of the IFCS flight test program conducted at the NASA Dryden Flight Research Center in 2006, with emphasis on challenges encountered and lessons learned.

Dissociable Fronto-Operculum-Insula Control Signals for Anticipation and Detection of Inhibitory Sensory Cue.

PubMed

Cai, Weidong; Chen, Tianwen; Ide, Jaime S; Li, Chiang-Shan R; Menon, Vinod

2017-08-01

The ability to anticipate and detect behaviorally salient stimuli is important for virtually all adaptive behaviors, including inhibitory control that requires the withholding of prepotent responses when instructed by external cues. Although right fronto-operculum-insula (FOI), encompassing the anterior insular cortex (rAI) and inferior frontal cortex (rIFC), involvement in inhibitory control is well established, little is known about signaling mechanisms underlying their differential roles in detection and anticipation of salient inhibitory cues. Here we use 2 independent functional magnetic resonance imaging data sets to investigate dynamic causal interactions of the rAI and rIFC, with sensory cortex during detection and anticipation of inhibitory cues. Across 2 different experiments involving auditory and visual inhibitory cues, we demonstrate that primary sensory cortex has a stronger causal influence on rAI than on rIFC, suggesting a greater role for the rAI in detection of salient inhibitory cues. Crucially, a Bayesian prediction model of subjective trial-by-trial changes in inhibitory cue anticipation revealed that the strength of causal influences from rIFC to rAI increased significantly on trials in which participants had higher anticipation of inhibitory cues. Together, these results demonstrate the dissociable bottom-up and top-down roles of distinct FOI regions in detection and anticipation of behaviorally salient cues across multiple sensory modalities. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome:a randomized group sequential comparative trial

PubMed Central

2011-01-01

Background In Traditional Chinese Medicine (TCM) theory, functional dyspepsia (FD) can be divided into different syndromes according to different clinical symptoms and signs, and the most common one is spleen-deficiency and qi-stagnation syndrome that can be treated by Chinese traditional patent medicine ---- two kinds of Zhizhu pills, between which the primary difference in ingredients is that one contains immature orange fruit of Citrus aurantium L.(IFCA) and the other contains that of Citrus sinensis Osbeck (IFCS). The trial's objective was to compare the efficacy of two kinds of Zhizhu pills on symptom changes in patients with FD of spleen-deficiency and qi-stagnation syndrome. Methods A randomized, group sequential, double-blinded, multicenter trial was conducted in patients with FD of spleen-deficiency and qi-stagnation syndrome at 3 hospitals in Beijing between June 2003 and May 2005. Participants were randomly allocated into two groups (IFCA group and IFCS group) in a 1:1 ratio, and respectively took one of the two kinds of Zhizhu pills orally, 6 g each time, 3 times a day, for 4 weeks. Statistical analysis was performed with use of a group sequential method, the triangular test (TT). Results A total of 163 patients were randomized, and 3 patients were excluded from analysis because of early dropouts, leaving 160 patients (IFCA group: n = 82; IFCS group: n = 78) for statistical analysis. Three interim analyses were done after 62, 116, and 160 patients had completed their 4-week treatment, respectively. At the third interim analysis, the sample path crossed the upper boundary and the trial was stopped, the cure-markedly effective rates were 45% for IFCS group and 67% for IFCA group, respectively, the one-sided p-value was 0.0036, the median unbiased estimate of the odds ratio (OR) for the benefit of IFCA relative to IFCS was 2.91 with 95%CI: 1.40 to 6.06. No adverse events were observed in the two groups. Conclusions Zhizhu pills containing IFCA was superior to Zhizhu pills containing IFCS in the treatment of FD of spleen-deficiency and qi-stagnation syndrome. The application of group sequential analysis in clinical trials of TCM may offer some financial and ethical benefits. Trial Registration Chinese Clinical Trial Registry (ChiCTR): ChiCTR-TRC-00000485 PMID:21762493

Application of image flow cytometry for the characterization of red blood cell morphology

NASA Astrophysics Data System (ADS)

Pinto, Ruben N.; Sebastian, Joseph A.; Parsons, Michael; Chang, Tim C.; Acker, Jason P.; Kolios, Michael C.

2017-02-01

Red blood cells (RBCs) stored in hypothermic environments for the purpose of transfusion have been documented to undergo structural and functional changes over time. One sign of the so-called RBC storage lesion is irreversible damage to the cell membrane. Consequently, RBCs undergo a morphological transformation from regular, deformable biconcave discocytes to rigid spheroechinocytes. The spherically shaped RBCs lack the deformability to efficiently enter microvasculature, thereby reducing the capacity of RBCs to oxygenate tissue. Blood banks currently rely on microscope techniques that include fixing, staining and cell counting in order to morphologically characterize RBC samples; these methods are labor intensive and highly subjective. This study presents a novel, high-throughput RBC morphology characterization technique using image flow cytometry (IFC). An image segmentation template was developed to process 100,000 images acquired from the IFC system and output the relative spheroechinocyte percentage. The technique was applied on samples extracted from two blood bags to monitor the morphological changes of the RBCs during in vitro hypothermic storage. The study found that, for a given sample of RBCs, the IFC method was twice as fast in data acquisition, and analyzed 250-350 times more RBCs than the conventional method. Over the lifespan of the blood bags, the mean spheroechinocyte population increased by 37%. Future work will focus on expanding the template to segregate RBC images into more subpopulations for the validation of the IFC method against conventional techniques; the expanded template will aid in establishing quantitative links between spheroechinocyte increase and other RBC storage lesion characteristics.

Transcutaneous electrical nerve stimulation reduces exercise-induced perceived pain and improves endurance exercise performance.

PubMed

Astokorki, Ali H Y; Mauger, Alexis R

2017-03-01

Muscle pain is a natural consequence of intense and prolonged exercise and has been suggested to be a limiter of performance. Transcutaneous electrical nerve stimulation (TENS) and interferential current (IFC) have been shown to reduce both chronic and acute pain in a variety of conditions. This study sought to ascertain whether TENS and IFC could reduce exercise-induced pain (EIP) and whether this would affect exercise performance. It was hypothesised that TENS and IFC would reduce EIP and result in an improved exercise performance. In two parts, 18 (Part I) and 22 (Part II) healthy male and female participants completed an isometric contraction of the dominant bicep until exhaustion (Part I) and a 16.1 km cycling time trial as quickly as they could (Part II) whilst receiving TENS, IFC, and a SHAM placebo in a repeated measures, randomised cross-over, and placebo-controlled design. Perceived EIP was recorded in both tasks using a validated subjective scale. In Part I, TENS significantly reduced perceived EIP (mean reduction of 12%) during the isometric contraction (P = 0.006) and significantly improved participants' time to exhaustion by a mean of 38% (P = 0.02). In Part II, TENS significantly improved (P = 0.003) participants' time trial completion time (~2% improvement) through an increased mean power output. These findings demonstrate that TENS can attenuate perceived EIP in a healthy population and that doing so significantly improves endurance performance in both submaximal isometric single limb exercise and whole-body dynamic exercise.

(BOREAS) BOREAS TE-8 Aspen Bark Chemistry Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Papagno, Andrea (Editor); Spencer, Shannon L.; Rock, Barrett N.

2000-01-01

The BOREAS TE-8 team collected pigment density data from aspen bark and leaves from four sites within the BOREAS SSA from 24-May-1994 to 16-Jun-1994 (IFC-1), 19-Jul-1994 to 08-Aug- 1994 (IFC-2), and 30-Aug-1994 to 19-Sep-1994 (IFC-3). One to nine trees from each site were sampled during the three IFCs. Each tree was sampled in five different locations for bark pigment properties: basal stem section, which was any bark sample taken below one-half the tree height; upper stem section, which was any bark sample taken from the main stem above one-half the tree height; bark taken from branches up to 3 years old; a 2-year-old branch segment, and a 1-year-old branch segment. Additionally, a limited number of leaves were collected. Bark samples were removed from the stem of the tree, placed in ziplock bags, and transported to UNH, where they were processed and analyzed by a spectrophotometer. In each data file, samples are identified by Site, Date, Tree#, and Sample Location (see I st paragraph above. Pigment density values are normalized to mg/m2. Density values for the following pigments are provided: Chi a, Chi b, Total Chi (Chi a+b), Carotenoids, Chi a to b ratio, and the Total Chi to carotenoids ratio. The data are stored in ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distrobuted Activity Archive Center (DAAC).

The O2 reduction at the IFC modified O2 fuel cell electrode

NASA Technical Reports Server (NTRS)

Fielder, William L.; Singer, Joseph; Baldwin, Richard S.; Johnson, Richard E.

1992-01-01

The International Fuel Corporation (IFC) state of the art (SOA) O2 electrode (Au-10 percent Pt electrocatalyst by weight) is currently being used in the alkaline H2-O2 fuel cell in the NASA Space Shuttle. Recently, IFC modified O2 electrode, as a possible replacement for the SOA electrode. In the present study, O2 reduction data were obtained for the modified electrode at temperatures between 23.3 and 91.7 C. BET measurements gave an electrode BET surface area of about 2070 sq. cm/sq. cm of geometric surface area. The Tafel data could be fitted to two straight line regions. The slope for the lower region, designated as the 0.04 V/decade region, was temperature dependent, and the transfer coefficient was about 1.5. The 'apparent' energy of activation for this region was about 19 kcal/mol. An O2 reduction mechanism for this 0.04 region is presented. In the upper region, designated as the 0.08 V/decade region, diffusion may be the controlling process. Tafel data are presented to illustrate the increase in performance with increasing temperature.

BOREAS TE-6 Multiband Vegetation Imager Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Kucharik, Christopher J.

2000-01-01

The BOREAS TE-6 team collected data in support of its efforts to examine the influence of vegetation and climate on the major carbon fluxes in boreal tree species. A newly developed ground-based canopy imaging system called an MVI was tested and used by the BOREAS TE-06 team to collect measurements of the canopy crap fraction (sky fraction), canopy gap-size distribution (size and frequency of gaps between foliage in canopy), branch architecture, and leaf angle distribution (fraction of leaf area in specific leaf inclination classes assuming azimuthal symmetry). Measurements of the canopy gap-size distribution are used to derive canopy clumping indices that can be used to adjust indirect LAI measurements made in nonrandom forests. These clumping factors will also help to describe the radiation penetration in clumped canopies more accurately by allowing for simple adjustments to Beer's law. Measurements of the above quantities were obtained at BOREAS NSA-OJP site in IFC-2 in 1994, at the SSA-OA in July 1995, and at the SSA-OBS and SSA-OA sites in IFC-2 in 1996. Modeling studies were also performed to further validate MVI measurements and to gain a more complete understanding of boreal forest canopy architecture. By using MVI measurements and Monte Carlo simulations, clumping indices as a function of zenith angle were derived for the three main boreal species studied during BOREAS. The analyzed data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distrobuted Activity Archive Center (DAAC).

Global screening for Critical Habitat in the terrestrial realm.

PubMed

Brauneder, Kerstin M; Montes, Chloe; Blyth, Simon; Bennun, Leon; Butchart, Stuart H M; Hoffmann, Michael; Burgess, Neil D; Cuttelod, Annabelle; Jones, Matt I; Kapos, Val; Pilgrim, John; Tolley, Melissa J; Underwood, Emma C; Weatherdon, Lauren V; Brooks, Sharon E

2018-01-01

Critical Habitat has become an increasingly important concept used by the finance sector and businesses to identify areas of high biodiversity value. The International Finance Corporation (IFC) defines Critical Habitat in their highly influential Performance Standard 6 (PS6), requiring projects in Critical Habitat to achieve a net gain of biodiversity. Here we present a global screening layer of Critical Habitat in the terrestrial realm, derived from global spatial datasets covering the distributions of 12 biodiversity features aligned with guidance provided by the IFC. Each biodiversity feature is categorised as 'likely' or 'potential' Critical Habitat based on: 1. Alignment between the biodiversity feature and the IFC Critical Habitat definition; and 2. Suitability of the spatial resolution for indicating a feature's presence on the ground. Following the initial screening process, Critical Habitat must then be assessed in-situ by a qualified assessor. This analysis indicates that a total of 10% and 5% of the global terrestrial environment can be considered as likely and potential Critical Habitat, respectively, while the remaining 85% did not overlap with any of the biodiversity features assessed and was classified as 'unknown'. Likely Critical Habitat was determined principally by the occurrence of Key Biodiversity Areas and Protected Areas. Potential Critical Habitat was predominantly characterised by data representing highly threatened and unique ecosystems such as ever-wet tropical forests and tropical dry forests. The areas we identified as likely or potential Critical Habitat are based on the best available global-scale data for the terrestrial realm that is aligned with IFC's Critical Habitat definition. Our results can help businesses screen potential development sites at the early project stage based on a range of biodiversity features. However, the study also demonstrates several important data gaps and highlights the need to incorporate new and improved global spatial datasets as they become available.

Shifted intrinsic connectivity of central executive and salience network in borderline personality disorder

PubMed Central

Doll, Anselm; Sorg, Christian; Manoliu, Andrei; Wöller, Andreas; Meng, Chun; Förstl, Hans; Zimmer, Claus; Wohlschläger, Afra M.; Riedl, Valentin

2013-01-01

Borderline personality disorder (BPD) is characterized by “stable instability” of emotions and behavior and their regulation. This emotional and behavioral instability corresponds with a neurocognitive triple network model of psychopathology, which suggests that aberrant emotional saliency and cognitive control is associated with aberrant interaction across three intrinsic connectivity networks [i.e., the salience network (SN), default mode network (DMN), and central executive network (CEN)]. The objective of the current study was to investigate whether and how such triple network intrinsic functional connectivity (iFC) is changed in patients with BPD. We acquired resting-state functional magnetic resonance imaging (rs-fMRI) data from 14 patients with BPD and 16 healthy controls. High-model order independent component analysis was used to extract spatiotemporal patterns of ongoing, coherent blood-oxygen-level-dependent signal fluctuations from rs-fMRI data. Main outcome measures were iFC within networks (intra-iFC) and between networks (i.e., network time course correlation inter-iFC). Aberrant intra-iFC was found in patients’ DMN, SN, and CEN, consistent with previous findings. While patients’ inter-iFC of the CEN was decreased, inter-iFC of the SN was increased. In particular, a balance index reflecting the relationship of CEN- and SN-inter-iFC across networks was strongly shifted from CEN to SN connectivity in patients. Results provide first preliminary evidence for aberrant triple network iFC in BPD. Our data suggest a shift of inter-network iFC from networks involved in cognitive control to those of emotion-related activity in BPD, potentially reflecting the persistent instability of emotion regulation in patients. PMID:24198777

Impaired fear recognition and attentional set-shifting is associated with brain structural changes in alcoholic patients

PubMed Central

Trick, Leanne; Kempton, Matthew J; Williams, Steven C R; Duka, Theodora

2014-01-01

Alcoholic patients with multiple detoxifications/relapses show cognitive and emotional deficits. We performed structural magnetic resonance imaging and examined performance on a cognitive flexibility task (intra-extradimensional set shift and reversal; IED). We also presented subjects with fearful, disgust and anger facial emotional expressions. Participants were abstaining, multiply detoxified (MDTx; n = 12) or singly detoxified patients (SDTx; n = 17) and social drinker controls (n = 31). Alcoholic patients were less able than controls to change their behavior in accordance with the changing of the rules in the IED and they were less accurate in recognizing fearful expressions in particular. They also showed lower gray matter volume compared with controls in frontal brain areas, including inferior frontal cortex (IFC) and insula that mediate emotional processing, inferior parietal lobule and medial frontal cortex that mediate attentional and motor planning processes, respectively. Impairments in performance and some of the regional decreases in gray matter were greater in MDTx. Gray matter volume in IFC in patients was negatively correlated with the number of detoxifications, whereas inferior parietal lobule was negatively correlated with the control over drinking score (impaired control over drinking questionnaire). Performance in IED was also negatively correlated with gray matter volume in IFC/BA47, whereas recognition of fearful faces was positively correlated with the IFC gray matter. Repeated episodes of detoxification from alcohol, related to severity of dependency, are coupled with altered brain structure in areas of emotional regulation, attention and motor planning. Such changes may confer increased inability to switch behavior according to environmental demands and social incompetence, contributing to relapse. PMID:25123156

3D Surveying, Modeling and Geo-Information System of the New Campus of ITB-Indonesia

NASA Astrophysics Data System (ADS)

Suwardhi, D.; Trisyanti, S. W.; Ainiyah, N.; Fajri, M. N.; Hanan, H.; Virtriana, R.; Edmarani, A. A.

2016-10-01

The new campus of ITB-Indonesia, which is located at Jatinangor, requires good facilities and infrastructures to supporting all of campus activities. Those can not be separated from procurement and maintenance activities. Technology for procurement and maintenance of facilities and infrastructures -based computer (information system)- has been known as Building Information Modeling (BIM). Nowadays, that technology is more affordable with some of free software that easy to use and tailored to user needs. BIM has some disadvantages and it requires other technologies to complete it, namely Geographic Information System (GIS). BIM and GIS require surveying data to visualized landscape and buildings on Jatinangor ITB campus. This paper presents the on-going of an internal service program conducted by the researcher, academic staff and students for the university. The program including 3D surveying to support the data requirements for 3D modeling of buildings in CityGML and Industry Foundation Classes (IFC) data model. The entire 3D surveying will produce point clouds that can be used to make 3D model. The 3D modeling is divided into low and high levels of detail modeling. The low levels model is stored in 3D CityGML database, and the high levels model including interiors is stored in BIM Server. 3D model can be used to visualized the building and site of Jatinangor ITB campus. For facility management of campus, an geo-information system is developed that can be used for planning, constructing, and maintaining Jatinangor ITB's facilities and infrastructures. The system uses openMAINT, an open source solution for the Property & Facility Management.

Integration of GIS and Bim for Indoor Geovisual Analytics

NASA Astrophysics Data System (ADS)

Wu, B.; Zhang, S.

2016-06-01

This paper presents an endeavour of integration of GIS (Geographical Information System) and BIM (Building Information Modelling) for indoor geovisual analytics. The merits of two types of technologies, GIS and BIM are firstly analysed in the context of indoor environment. GIS has well-developed capabilities of spatial analysis such as network analysis, while BIM has the advantages for indoor 3D modelling and dynamic simulation. This paper firstly investigates the important aspects for integrating GIS and BIM. Different data standards and formats such as the IFC (Industry Foundation Classes) and GML (Geography Markup Language) are discussed. Their merits and limitations in data transformation between GIS and BIM are analysed in terms of semantic and geometric information. An optimized approach for data exchange between GIS and BIM datasets is then proposed. After that, a strategy of using BIM for 3D indoor modelling, GIS for spatial analysis, and BIM again for visualization and dynamic simulation of the analysis results is presented. Based on the developments, this paper selects a typical problem, optimized indoor emergency evacuation, to demonstrate the integration of GIS and BIM for indoor geovisual analytics. The block Z of the Hong Kong Polytechnic University is selected as a test site. Detailed indoor and outdoor 3D models of the block Z are created using a BIM software Revit. The 3D models are transferred to a GIS software ArcGIS to carry out spatial analysis. Optimized evacuation plans considering dynamic constraints are generated based on network analysis in ArcGIS assuming there is a fire accident inside the building. The analysis results are then transferred back to BIM software for visualization and dynamic simulation. The developed methods and results are of significance to facilitate future development of GIS and BIM integrated solutions in various applications.

Physically founded phonon dispersions of few-layer materials and the case of borophene

DOE PAGES

Carrete, Jesús; Li, Wu; Lindsay, Lucas; ...

2016-04-21

By building physically sound interatomic force constants,we offer evidence of the universal presence of a quadratic phonon branch in all unstrained 2D materials, thus contradicting much of the existing literature. Through a reformulation of the interatomic force constants (IFCs) in terms of internal coordinates, we find that a delicate balance between the IFCs is responsible for this quadraticity. We use this approach to predict the thermal conductivity of Pmmn borophene, which is comparable to that of MoS 2, and displays a remarkable in-plane anisotropy. Ultimately, these qualities may enable the efficient heat management of borophene devices in potential nanoelectronic applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, Hua; College of Physics and Optoelectronics, Taiyuan University of Technology, Taiyuan 030024; Kioussis, Nicholas, E-mail: nick.kioussis@csun.edu

Using ab initio based calculations, we have calculated the intrinsic lattice thermal conductivity of chiral tellurium. We show that the interplay between the strong covalent intrachain and weak van der Waals interchain interactions gives rise to the phonon band gap between the lower and higher optical phonon branches. The underlying mechanism of the large anisotropy of the thermal conductivity is the anisotropy of the phonon group velocities and of the anharmonic interatomic force constants (IFCs), where large interchain anharmonic IFCs are associated with the lone electron pairs. We predict that tellurium has a large three-phonon scattering phase space that resultsmore » in low thermal conductivity. The thermal conductivity anisotropy decreases under applied hydrostatic pressure.« less

The Intelligent Flight Control Program (IFCS)

NASA Technical Reports Server (NTRS)

2004-01-01

This is the closeout report for the Research Cooperative Agreement NCC4-00130 of accomplishments for the Intelligent Flight Control System (IFCS) Project. It has been a pleasure working with NASA and NASA partners as we strive to meet the goals of this research initiative. ISR was engaged in this Research Cooperative Agreement beginning 01 January 2003 and ending 31 January 2004. During this time ISR conducted efforts towards development of the ARTS II Computer Software Configuration Item (CSCI) version 4.0 by performing or developing the following: 1) Requirements Definition; 2) Software Design and Development; 3) Hardware In the Loop Simulation; 4) Unit Level testing; 5) Documentation.

Inferring the Functions of Proteins from the Interrelationships between Functional Categories.

PubMed

Taha, Kamal

2018-01-01

This study proposes a new method to determine the functions of an unannotated protein. The proteins and amino acid residues mentioned in biomedical texts associated with an unannotated protein can be considered as characteristics terms for , which are highly predictive of the potential functions of . Similarly, proteins and amino acid residues mentioned in biomedical texts associated with proteins annotated with a functional category can be considered as characteristics terms of . We introduce in this paper an information extraction system called IFP_IFC that predicts the functions of an unannotated protein by representing and each functional category by a vector of weights. Each weight reflects the degree of association between a characteristic term and (or a characteristic term and ). First, IFP_IFC constructs a network, whose nodes represent the different functional categories, and its edges the interrelationships between the nodes. Then, it determines the functions of by employing random walks with restarts on the mentioned network. The walker is the vector of . Finally, is assigned to the functional categories of the nodes in the network that are visited most by the walker. We evaluated the quality of IFP_IFC by comparing it experimentally with two other systems. Results showed marked improvement.

Investigating Integration Capabilities Between Ifc and Citygml LOD3 for 3d City Modelling

NASA Astrophysics Data System (ADS)

Floros, G.; Pispidikis, I.; Dimopoulou, E.

2017-10-01

Smart cities are applied to an increasing number of application fields. This evolution though urges data collection and integration, hence major issues arise that need to be tackled. One of the most important challenges is the heterogeneity of collected data, especially if those data derive from different standards and vary in terms of geometry, topology and semantics. Another key challenge is the efficient analysis and visualization of spatial data, which due to the complexity of the physical reality in modern world, 2D GIS struggles to cope with. So, in order to facilitate data analysis and enhance the role of smart cities, the 3rd dimension needs to be implemented. Standards such as CityGML and IFC fulfill that necessity but they present major differences in their schemas that render their integration a challenging task. This paper focuses on addressing those differences, examining the up to date research work and investigates an alternative methodology in order to bridge the gap between those Standards. Within this framework, a generic IFC model is generated and converted to a CityGML Model, which is validated and evaluated on its geometrical correctness and semantical coherence. General results as well as future research considerations are presented.

Basic dynamics from a pulse-coupled network of autonomous integrate-and-fire chaotic circuits.

PubMed

Nakano, H; Saito, T

2002-01-01

This paper studies basic dynamics from a novel pulse-coupled network (PCN). The unit element of the PCN is an integrate-and-fire circuit (IFC) that exhibits chaos. We an give an iff condition for the chaos generation. Using two IFC, we construct a master-slave PCN. It exhibits interesting chaos synchronous phenomena and their breakdown phenomena. We give basic classification of the phenomena and their existence regions can be elucidated in the parameter space. We then construct a ring-type PCN and elucidate that the PCN exhibits interesting grouping phenomena based on the chaos synchronization patterns. Using a simple test circuit, some of typical phenomena can be verified in the laboratory.

[SUPPORT, CO-OPERATIVE EDUCATION PROGRAMMES, PRAGMATIC CODE OF ETHICS: A CLINICAL APPROACH OF EXECUTIVE TRAINING].

PubMed

Cabaret, Véronique

2016-01-01

This article aims at introducing an educational sequence completed at l'Institut de Formation des Cadres de Santé (IFCS) at the CHRU in Lille in France, entitled "training project and educational project" present in the "training duties" module whose goal is to generate students'knowledge through co-operative education programmes. By creating this innovative sequence, the educational aim is to use the Institut ground as a ground of learning, associated with the various internship grounds, in order to get the most of co-operative education programmes. Besides, in a pragmatic code of ethics in training, the teaching staff draw their inspiration from a clinical approach of executive training: they regard students as true protagonists in a co-operative plan created for them, wishing to design it with them using their words. Thus, students are brought to criticize the IFCS educational project and debate it with the trainers who have built it. Each partner tries to understand the Other, being aware of their being different. By contributing every year to rewriting the educational project which directly concerns them, students build their professional positions as health executives. They play an active role in co-operative education programmes just like IFCS outside partners.

Anomalous random correlations of force constants on the lattice dynamical properties of disordered Au-Fe alloys

NASA Astrophysics Data System (ADS)

Kangsabanik, Jiban; Chouhan, Rajiv K.; Johnson, D. D.; Alam, Aftab

2017-09-01

Gold iron (Au-Fe) alloys are of immense interest due to their biocompatibility, anomalous Hall conductivity, and applications in various medical treatments. However, irrespective of the method of preparation, they often exhibit a high level of disorder with properties sensitive to the thermal or magnetic annealing temperatures. We calculate the lattice dynamical properties of Au1 -xFex alloys using density functional theory methods where, being multisite properties, reliable interatomic force constant (IFC) calculations in disordered alloys remain a challenge. We follow a twofold approach: (1) an accurate IFC calculation in an environment with nominally zero chemical pair correlations to mimic the homogeneously disordered alloy and (2) a configurational averaging for the desired phonon properties (e.g., dispersion, density of states, and entropy). We find an anomalous change in the IFC's and phonon dispersion (split bands) near x =0.19 , which is attributed to the local stiffening of the Au-Au bonds when Au is in the vicinity of Fe. Other results based on mechanical and thermophysical properties reflect a similar anomaly: Phonon entropy, e.g., becomes negative below x =0.19 , suggesting a tendency for chemical unmixing, reflecting the onset of a miscibility gap in the phase diagram. Our results match fairly well with reported data wherever available.

Flight Investigation of Prescribed Simultaneous Independent Surface Excitations for Real-Time Parameter Identification

NASA Technical Reports Server (NTRS)

Moes, Timothy R.; Smith, Mark S.; Morelli, Eugene A.

2003-01-01

Near real-time stability and control derivative extraction is required to support flight demonstration of Intelligent Flight Control System (IFCS) concepts being developed by NASA, academia, and industry. Traditionally, flight maneuvers would be designed and flown to obtain stability and control derivative estimates using a postflight analysis technique. The goal of the IFCS concept is to be able to modify the control laws in real time for an aircraft that has been damaged in flight. In some IFCS implementations, real-time parameter identification (PID) of the stability and control derivatives of the damaged aircraft is necessary for successfully reconfiguring the control system. This report investigates the usefulness of Prescribed Simultaneous Independent Surface Excitations (PreSISE) to provide data for rapidly obtaining estimates of the stability and control derivatives. Flight test data were analyzed using both equation-error and output-error PID techniques. The equation-error PID technique is known as Fourier Transform Regression (FTR) and is a frequency-domain real-time implementation. Selected results were compared with a time-domain output-error technique. The real-time equation-error technique combined with the PreSISE maneuvers provided excellent derivative estimation in the longitudinal axis. However, the PreSISE maneuvers as presently defined were not adequate for accurate estimation of the lateral-directional derivatives.

PreSMA stimulation changes task-free functional connectivity in the fronto-basal-ganglia that correlates with response inhibition efficiency

PubMed Central

Xu, Benjamin; Sandrini, Marco; Wang, Wen-tung; Smith, Jason F.; Sarlls, Joelle E.; Awosika, Oluwole; Butman, John A.; Horwitz, Barry; Cohen, Leonardo G.

2016-01-01

Previous work using transcranial magnetic stimulation (TMS) demonstrated that the right pre-supplementary motor area (preSMA), a node in the fronto-basal-ganglia network, is critical for response inhibition. However, TMS influences interconnected regions, raising the possibility of a link between the preSMA activity and the functional connectivity within the network. To understand this relationship, we applied single-pulse TMS to the right preSMA during functional magnetic resonance imaging when the subjects were at rest to examine changes in neural activity and functional connectivity within the network in relation to the efficiency of response inhibition evaluated with a stop-signal task. The results showed that preSMA-TMS increased activation in the right inferior-frontal cortex (rIFC) and basal ganglia and modulated their task-free functional connectivity. Both the TMS-induced changes in the basal-ganglia activation and the functional connectivity between rIFC and left striatum, and of the overall network correlated with the efficiency of response inhibition and with the white-matter microstructure along the preSMA – rIFC pathway. These results suggest that the task-free functional and structural connectivity between the rIFCop and basal ganglia are critical to the efficiency of response inhibition. PMID:27144466

Reorganization of brain function after a short-term behavioral intervention for stuttering.

PubMed

Lu, Chunming; Zheng, Lifen; Long, Yuhang; Yan, Qian; Ding, Guosheng; Liu, Li; Peng, Danling; Howell, Peter

2017-05-01

This study investigated changes in brain function that occurred over a 7-day behavioral intervention for adults who stutter (AWS). Thirteen AWS received the intervention (AWS+), and 13 AWS did not receive the intervention (AWS-). There were 13 fluent controls (FC-). All participants were scanned before and after the intervention. Whole-brain analysis pre-intervention showed significant differences in task-related brain activation between AWS and FC- in the right inferior frontal cortex (IFC) and left middle temporal cortex, but there were no differences between the two AWS groups. Across the 7-day period of the intervention, AWS+ alone showed a significant increase of brain activation in the left ventral IFC/insula. There were no changes in brain function for the other two groups. Further analysis revealed that the change did not correlate with resting-state functional connectivity (RSFC) that AWS showed in the cerebellum (Lu et al., 2012). However, both changes in task-related brain function and RSFC correlated with changes in speech fluency level. Together, these findings suggest that functional reorganization in a brain region close to the left IFC that shows anomalous function in AWS, occurs after a short-term behavioral intervention for stuttering. Copyright © 2017 Elsevier Inc. All rights reserved.

Anomalous random correlations of force constants on the lattice dynamical properties of disordered Au-Fe alloys

DOE PAGES

Kangsabanik, Jiban; Chouhan, Rajiv K.; Johnson, D. D.; ...

2017-09-20

Here, gold iron (Au-Fe) alloys are of immense interest due to their biocompatibility, anomalous Hall conductivity, and applications in various medical treatments. However, irrespective of the method of preparation, they often exhibit a high level of disorder with properties sensitive to the thermal or magnetic annealing temperatures. We calculate the lattice dynamical properties of Au 1–xFe x alloys using density functional theory methods where, being multisite properties, reliable interatomic force constant (IFC) calculations in disordered alloys remain a challenge. We follow a twofold approach: an accurate IFC calculation in an environment with nominally zero chemical pair correlations to mimic themore » homogeneously disordered alloy and a configurational averaging for the desired phonon properties (e.g., dispersion, density of states, and entropy). We find an anomalous change in the IFC's and phonon dispersion (split bands) near x=0.19, which is attributed to the local stiffening of the Au-Au bonds when Au is in the vicinity of Fe. Other results based on mechanical and thermophysical properties reflect a similar anomaly: Phonon entropy, e.g., becomes negative below x=0.19, suggesting a tendency for chemical unmixing, reflecting the onset of a miscibility gap in the phase diagram. Our results match fairly well with reported data wherever available.« less

Anomalous random correlations of force constants on the lattice dynamical properties of disordered Au-Fe alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kangsabanik, Jiban; Chouhan, Rajiv K.; Johnson, D. D.

Here, gold iron (Au-Fe) alloys are of immense interest due to their biocompatibility, anomalous Hall conductivity, and applications in various medical treatments. However, irrespective of the method of preparation, they often exhibit a high level of disorder with properties sensitive to the thermal or magnetic annealing temperatures. We calculate the lattice dynamical properties of Au 1–xFe x alloys using density functional theory methods where, being multisite properties, reliable interatomic force constant (IFC) calculations in disordered alloys remain a challenge. We follow a twofold approach: an accurate IFC calculation in an environment with nominally zero chemical pair correlations to mimic themore » homogeneously disordered alloy and a configurational averaging for the desired phonon properties (e.g., dispersion, density of states, and entropy). We find an anomalous change in the IFC's and phonon dispersion (split bands) near x=0.19, which is attributed to the local stiffening of the Au-Au bonds when Au is in the vicinity of Fe. Other results based on mechanical and thermophysical properties reflect a similar anomaly: Phonon entropy, e.g., becomes negative below x=0.19, suggesting a tendency for chemical unmixing, reflecting the onset of a miscibility gap in the phase diagram. Our results match fairly well with reported data wherever available.« less

Regional statistical assessment of WRF-Hydro and IFC Model stream Flow uncertainties over the State of Iowa

NASA Astrophysics Data System (ADS)

ElSaadani, M.; Quintero, F.; Goska, R.; Krajewski, W. F.; Lahmers, T.; Small, S.; Gochis, D. J.

2015-12-01

This study examines the performance of different Hydrologic models in estimating peak flows over the state of Iowa. In this study I will compare the output of the Iowa Flood Center (IFC) hydrologic model and WRF-Hydro (NFIE configuration) to the observed flows at the USGS stream gauges. During the National Flood Interoperability Experiment I explored the performance of WRF-Hydro over the state of Iowa using different rainfall products and the resulting hydrographs showed a "flashy" behavior of the model output due to lack of calibration and bad initial flows due to short model spin period. I would like to expand this study by including a second well established hydrologic model and include more rain gauge vs. radar rainfall direct comparisons. The IFC model is expected to outperform WRF-Hydro's out of the box results, however, I will test different calibration options for both the Noah-MP land surface model and RAPID, which is the routing component of the NFIE-Hydro configuration, to see if this will improve the model results. This study will explore the statistical structure of model output uncertainties across scales (as a function of drainage areas and/or stream orders). I will also evaluate the performance of different radar-based Quantitative Precipitation Estimation (QPE) products (e.g. Stage IV, MRMS and IFC's NEXRAD based radar rainfall product. Different basins will be evaluated in this study and they will be selected based on size, amount of rainfall received over the basin area and location. Basin location will be an important factor in this study due to our prior knowledge of the performance of different NEXRAD radars that cover the region, this will help observe the effect of rainfall biases on stream flows. Another possible addition to this study is to apply controlled spatial error fields to rainfall inputs and observer the propagation of these errors through the stream network.

Bayesian classification theory

NASA Technical Reports Server (NTRS)

Hanson, Robin; Stutz, John; Cheeseman, Peter

1991-01-01

The task of inferring a set of classes and class descriptions most likely to explain a given data set can be placed on a firm theoretical foundation using Bayesian statistics. Within this framework and using various mathematical and algorithmic approximations, the AutoClass system searches for the most probable classifications, automatically choosing the number of classes and complexity of class descriptions. A simpler version of AutoClass has been applied to many large real data sets, has discovered new independently-verified phenomena, and has been released as a robust software package. Recent extensions allow attributes to be selectively correlated within particular classes, and allow classes to inherit or share model parameters though a class hierarchy. We summarize the mathematical foundations of AutoClass.

High-Performance, Low Environmental Impact Refrigerants

NASA Technical Reports Server (NTRS)

McCullough, E. T.; Dhooge, P. M.; Glass, S. M.; Nimitz, J. S.

2001-01-01

Refrigerants used in process and facilities systems in the US include R-12, R-22, R-123, R-134a, R-404A, R-410A, R-500, and R-502. All but R-134a, R-404A, and R-410A contain ozone-depleting substances that will be phased out under the Montreal Protocol. Some of the substitutes do not perform as well as the refrigerants they are replacing, require new equipment, and have relatively high global warming potentials (GWPs). New refrigerants are needed that addresses environmental, safety, and performance issues simultaneously. In efforts sponsored by Ikon Corporation, NASA Kennedy Space Center (KSC), and the US Environmental Protection Agency (EPA), ETEC has developed and tested a new class of refrigerants, the Ikon (registered) refrigerants, based on iodofluorocarbons (IFCs). These refrigerants are nonflammable, have essentially zero ozone-depletion potential (ODP), low GWP, high performance (energy efficiency and capacity), and can be dropped into much existing equipment.

PreSMA stimulation changes task-free functional connectivity in the fronto-basal-ganglia that correlates with response inhibition efficiency.

PubMed

Xu, Benjamin; Sandrini, Marco; Wang, Wen-Tung; Smith, Jason F; Sarlls, Joelle E; Awosika, Oluwole; Butman, John A; Horwitz, Barry; Cohen, Leonardo G

2016-09-01

Previous work using transcranial magnetic stimulation (TMS) demonstrated that the right presupplementary motor area (preSMA), a node in the fronto-basal-ganglia network, is critical for response inhibition. However, TMS influences interconnected regions, raising the possibility of a link between the preSMA activity and the functional connectivity within the network. To understand this relationship, we applied single-pulse TMS to the right preSMA during functional magnetic resonance imaging when the subjects were at rest to examine changes in neural activity and functional connectivity within the network in relation to the efficiency of response inhibition evaluated with a stop-signal task. The results showed that preSMA-TMS increased activation in the right inferior-frontal cortex (rIFC) and basal ganglia and modulated their task-free functional connectivity. Both the TMS-induced changes in the basal-ganglia activation and the functional connectivity between rIFC and left striatum, and of the overall network correlated with the efficiency of response inhibition and with the white-matter microstructure along the preSMA-rIFC pathway. These results suggest that the task-free functional and structural connectivity between the rIFCop and basal ganglia are critical to the efficiency of response inhibition. Hum Brain Mapp 37:3236-3249, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability

PubMed Central

Xu, Ting; Opitz, Alexander; Craddock, R. Cameron; Wright, Margaret J.; Zuo, Xi-Nian; Milham, Michael P.

2016-01-01

Resting state fMRI (R-fMRI) is a powerful in-vivo tool for examining the functional architecture of the human brain. Recent studies have demonstrated the ability to characterize transitions between functionally distinct cortical areas through the mapping of gradients in intrinsic functional connectivity (iFC) profiles. To date, this novel approach has primarily been applied to iFC profiles averaged across groups of individuals, or in one case, a single individual scanned multiple times. Here, we used a publically available R-fMRI dataset, in which 30 healthy participants were scanned 10 times (10 min per session), to investigate differences in full-brain transition profiles (i.e., gradient maps, edge maps) across individuals, and their reliability. 10-min R-fMRI scans were sufficient to achieve high accuracies in efforts to “fingerprint” individuals based upon full-brain transition profiles. Regarding test–retest reliability, the image-wise intraclass correlation coefficient (ICC) was moderate, and vertex-level ICC varied depending on region; larger durations of data yielded higher reliability scores universally. Initial application of gradient-based methodologies to a recently published dataset obtained from twins suggested inter-individual variation in areal profiles might have genetic and familial origins. Overall, these results illustrate the utility of gradient-based iFC approaches for studying inter-individual variation in brain function. PMID:27600846

The association of children's mathematic abilities with both adults' cognitive abilities and intrinsic fronto-parietal networks is altered in preterm-born individuals.

PubMed

Bäuml, J G; Meng, C; Daamen, M; Baumann, N; Busch, B; Bartmann, P; Wolke, D; Boecker, H; Wohlschläger, A; Sorg, C; Jaekel, Julia

2017-03-01

Mathematic abilities in childhood are highly predictive for long-term neurocognitive outcomes. Preterm-born individuals have an increased risk for both persistent cognitive impairments and long-term changes in macroscopic brain organization. We hypothesized that the association of childhood mathematic abilities with both adulthood general cognitive abilities and associated fronto-parietal intrinsic networks is altered after preterm delivery. 72 preterm- and 71 term-born individuals underwent standardized mathematic and IQ testing at 8 years and resting-state fMRI and full-scale IQ testing at 26 years of age. Outcome measure for intrinsic networks was intrinsic functional connectivity (iFC). Controlling for IQ at age eight, mathematic abilities in childhood were significantly stronger positively associated with adults' IQ in preterm compared with term-born individuals. In preterm-born individuals, the association of children's mathematic abilities and adults' fronto-parietal iFC was altered. Likewise, fronto-parietal iFC was distinctively linked with preterm- and term-born adults' IQ. Results provide evidence that preterm birth alters the link of mathematic abilities in childhood and general cognitive abilities and fronto-parietal intrinsic networks in adulthood. Data suggest a distinct functional role of intrinsic fronto-parietal networks for preterm individuals with respect to mathematic abilities and that these networks together with associated children's mathematic abilities may represent potential neurocognitive targets for early intervention.

Accelerating evaluation of converged lattice thermal conductivity

NASA Astrophysics Data System (ADS)

Qin, Guangzhao; Hu, Ming

2018-01-01

High-throughput computational materials design is an emerging area in materials science, which is based on the fast evaluation of physical-related properties. The lattice thermal conductivity (κ) is a key property of materials for enormous implications. However, the high-throughput evaluation of κ remains a challenge due to the large resources costs and time-consuming procedures. In this paper, we propose a concise strategy to efficiently accelerate the evaluation process of obtaining accurate and converged κ. The strategy is in the framework of phonon Boltzmann transport equation (BTE) coupled with first-principles calculations. Based on the analysis of harmonic interatomic force constants (IFCs), the large enough cutoff radius (rcutoff), a critical parameter involved in calculating the anharmonic IFCs, can be directly determined to get satisfactory results. Moreover, we find a simple way to largely ( 10 times) accelerate the computations by fast reconstructing the anharmonic IFCs in the convergence test of κ with respect to the rcutof, which finally confirms the chosen rcutoff is appropriate. Two-dimensional graphene and phosphorene along with bulk SnSe are presented to validate our approach, and the long-debate divergence problem of thermal conductivity in low-dimensional systems is studied. The quantitative strategy proposed herein can be a good candidate for fast evaluating the reliable κ and thus provides useful tool for high-throughput materials screening and design with targeted thermal transport properties.

Effect of Adding Interferential Current in an Exercise and Manual Therapy Program for Patients With Unilateral Shoulder Impingement Syndrome: A Randomized Clinical Trial.

PubMed

Gomes, Cid André Fidelis de Paula; Dibai-Filho, Almir Vieira; Moreira, William Arruda; Rivas, Shirley Quispe; Silva, Emanuela Dos Santos; Garrido, Ana Claudia Bogik

The purpose of this study was to measure the additional effect of adding interferential current (IFC) to an exercise and manual therapy program for patients with unilateral shoulder impingement syndrome. Forty-five participants were randomly assigned to group 1 (exercise and manual therapy), group 2 (exercise and manual therapy + IFC), or group 3 (exercise and manual therapy + placebo ultrasound). Individuals participated in 16 treatment sessions, twice a week for 8 weeks. The primary outcome of the study was total score of the Shoulder Pain and Disability Index (SPADI). The secondary outcomes were the pain and disability subscales of SPADI, Numeric Rating Scale, and Pain-Related Self-Statement Scale. Adjusted between-group mean differences (MDs) and 95% confidence intervals (CIs) were calculated using linear mixed models. After 16 treatment sessions, statistically significant but not clinically important differences were identified in favor of the exercise and manual therapy program alone in the SPADI-total (group 1 vs group 2, MD 11.12 points, 95% CI 5.90-16.35; group 1 vs group 3, MD 13.43 points, 95% CI 8.21-18.65). Similar results were identified for secondary outcomes. The addition of IFC does not generate greater clinical effects in an exercise and manual therapy program for individuals with unilateral shoulder impingement syndrome. Copyright © 2018. Published by Elsevier Inc.

Autoclass: An automatic classification system

NASA Technical Reports Server (NTRS)

Stutz, John; Cheeseman, Peter; Hanson, Robin

1991-01-01

The task of inferring a set of classes and class descriptions most likely to explain a given data set can be placed on a firm theoretical foundation using Bayesian statistics. Within this framework, and using various mathematical and algorithmic approximations, the AutoClass System searches for the most probable classifications, automatically choosing the number of classes and complexity of class descriptions. A simpler version of AutoClass has been applied to many large real data sets, has discovered new independently-verified phenomena, and has been released as a robust software package. Recent extensions allow attributes to be selectively correlated within particular classes, and allow classes to inherit, or share, model parameters through a class hierarchy. The mathematical foundations of AutoClass are summarized.

F-15 IFCS Intelligent Flight Control System

NASA Technical Reports Server (NTRS)

Bosworth, John T.

2008-01-01

This viewgraph presentation gives a detailed description of the F-15 aircraft, flight tests, aircraft performance and overall advanced neural network based flight control technologies for aerospace systems designs.

A 'new' Cromer-related high frequency antigen probably antithetical to WES.

PubMed

Daniels, G L; Green, C A; Darr, F W; Anderson, H; Sistonen, P

1987-01-01

An antibody to a high frequency antigen, made in a WES+ Black antenatal patient (Wash.), failed to react with the red cells of a presumed WES+ homozygote and is, therefore, probably antithetical to anti-WES. Like anti-WES, it reacted with papain, ficin, trypsin or neuraminidase treated cells but not with alpha-chymotrypsin or pronase treated cells and was specifically inhibited by concentrated serum. It also reacted more strongly in titration with WES- cells than with WES+ cells. The antibody is Cromer-related as it failed to react with Inab phenotype (IFC-) cells and reacted only weakly with Dr(a-) cells. Wash. cells and those of the other possible WES+ homozygote are Cr(a+) Tc(a+b-c-) Dr(a+) IFC+ but reacted only very weakly with anti-Esa.

Dyslexic children lack word selectivity gradients in occipito-temporal and inferior frontal cortex.

PubMed

Olulade, O A; Flowers, D L; Napoliello, E M; Eden, G F

2015-01-01

fMRI studies using a region-of-interest approach have revealed that the ventral portion of the left occipito-temporal cortex, which is specialized for orthographic processing of visually presented words (and includes the so-called "visual word form area", VWFA), is characterized by a posterior-to-anterior gradient of increasing selectivity for words in typically reading adults, adolescents, and children (e.g. Brem et al., 2006, 2009). Similarly, the left inferior frontal cortex (IFC) has been shown to exhibit a medial-to-lateral gradient of print selectivity in typically reading adults (Vinckier et al., 2007). Functional brain imaging studies of dyslexia have reported relative underactivity in left hemisphere occipito-temporal and inferior frontal regions using whole-brain analyses during word processing tasks. Hence, the question arises whether gradient sensitivities in these regions are altered in dyslexia. Indeed, a region-of-interest analysis revealed the gradient-specific functional specialization in the occipito-temporal cortex to be disrupted in dyslexic children (van der Mark et al., 2009). Building on these studies, we here (1) investigate if a word-selective gradient exists in the inferior frontal cortex in addition to the occipito-temporal cortex in normally reading children, (2) compare typically reading with dyslexic children, and (3) examine functional connections between these regions in both groups. We replicated the previously reported anterior-to-posterior gradient of increasing selectivity for words in the left occipito-temporal cortex in typically reading children, and its absence in the dyslexic children. Our novel finding is the detection of a pattern of increasing selectivity for words along the medial-to-lateral axis of the left inferior frontal cortex in typically reading children and evidence of functional connectivity between the most lateral aspect of this area and the anterior aspects of the occipito-temporal cortex. We report absence of an IFC gradient and connectivity between the lateral aspect of the IFC and the anterior occipito-temporal cortex in the dyslexic children. Together, our results provide insights into the source of the anomalies reported in previous studies of dyslexia and add to the growing evidence of an orthographic role of IFC in reading.

Aerosol Optical Depth Determinations for BOREAS

NASA Technical Reports Server (NTRS)

Wrigley, R. C.; Livingston, J. M.; Russell, P. B.; Guzman, R. P.; Ried, D.; Lobitz, B.; Peterson, David L. (Technical Monitor)

1994-01-01

Automated tracking sun photometers were deployed by NASA/Ames Research Center aboard the NASA C-130 aircraft and at a ground site for all three Intensive Field Campaigns (IFCs) of the Boreal Ecosystem-Atmosphere Study (BOREAS) in central Saskatchewan, Canada during the summer of 1994. The sun photometer data were used to derive aerosol optical depths for the total atmospheric column above each instrument. The airborne tracking sun photometer obtained data in both the southern and northern study areas at the surface prior to takeoff, along low altitude runs near the ground tracking sun photometer, during ascents to 6-8 km msl, along remote sensing flightlines at altitude, during descents to the surface, and at the surface after landing. The ground sun photometer obtained data from the shore of Candle Lake in the southern area for all cloud-free times. During the first IFC in May-June ascents and descents of the airborne tracking sun photometer indicated the aerosol optical depths decreased steadily from the surface to 3.5 kni where they leveled out at approximately 0.05 (at 525 nm), well below levels caused by the eruption of Mt. Pinatubo. On a very clear day, May 31st, surface optical depths measured by either the airborne or ground sun photometers approached those levels (0.06-0.08 at 525 nm), but surface optical depths were often several times higher. On June 4th they increased from 0.12 in the morning to 0.20 in the afternoon with some evidence of brief episodes of pollen bursts. During the second IFC surface aerosol optical depths were variable in the extreme due to smoke from western forest fires. On July 20th the aerosol optical depth at 525 nm decreased from 0.5 in the morning to 0.2 in the afternoon; they decreased still further the next day to 0.05 and remained consistently low throughout the day to provide excellent conditions for several remote sensing missions flown that day. Smoke was heavy for the early morning of July 24th but cleared partially by 10:30 local time and cleared fully by 11:30. Heavy smoke characterized the rest of the IFC in both study areas.

Theoretical and computational foundations of management class simulation

Treesearch

Denie Gerold

1978-01-01

Investigations on complicated, complex, and not well-ordered systems are possible only with the aid of mathematical methods and electronic data processing. Simulation as a method of operations research is particularly suitable for this purpose. Theoretical and computational foundations of management class simulation must be integrated into the planning systems of...

Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study

PubMed Central

Singh, Krish D.; Verbruggen, Frederick

2018-01-01

This pre-registered experiment sought to uncover the temporal relationship between the inferior frontal cortex (IFC) and the pre-supplementary motor area (pre-SMA) during stopping of an ongoing action. Both regions have previously been highlighted as being central to cognitive control of actions, particularly response inhibition. Here we tested which area is activated first during the stopping process using magnetoencephalography, before assessing the relative chronometry of each region using functionally localized transcranial magnetic stimulation. Both lines of evidence pointed towards simultaneous activity across both regions, suggesting that parallel, mutually interdependent processing may form the cortical basis of stopping. Additional exploratory analysis, however, provided weak evidence in support of previous suggestions that the pre-SMA may provide an ongoing drive of activity to the IFC. PMID:29515852

Schizotypal Traits are Linked to Dopamine-Induced Striato-Cortical Decoupling: A Randomized Double-Blind Placebo-Controlled Study.

PubMed

Rössler, Julian; Unterassner, Lui; Wyss, Thomas; Haker, Helene; Brugger, Peter; Rössler, Wulf; Wotruba, Diana

2018-06-07

The dopamine hypothesis of schizophrenia implies that alterations in the dopamine system cause functional abnormalities in the brain that may converge to aberrant salience attribution and eventually lead to psychosis. Indeed, widespread brain disconnectivity across the psychotic spectrum has been revealed by resting-state functional magnetic resonance imaging (rs-fMRI). However, the dopaminergic involvement in intrinsic functional connectivity (iFC) and its putative relationship to the development of psychotic spectrum disorders remains partly unclear-in particular at the low-end of the psychosis continuum. Therefore, we investigated dopamine-induced changes in striatal iFC and their modulation by psychometrically assessed schizotypy. Our randomized, double-blind placebo-controlled study design included 54 healthy, right-handed male participants. Each participant was assessed with the Schizotypal Personality Questionnaire (SPQ) and underwent 10 minutes of rs-fMRI scanning. Participants then received either a placebo or 200 mg of L-DOPA, a dopamine precursor. We analyzed iFC of 6 striatal seeds that are known to evoke modulation of dopamine-related networks. The main effect of L-DOPA was a significant functional decoupling from the right ventral caudate to both occipital fusiform gyri. This dopamine-induced decoupling emerged primarily in participants with low SPQ scores, while participants with high positive SPQ scores showed decoupling indifferently of the L-DOPA challenge. Taken together, these findings demonstrate that schizotypal traits may be the result of dopamine-induced striato-occipital decoupling.

Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism

PubMed Central

Woolley, Daniel G.; Steyaert, Jean; Di Martino, Adriana; Swinnen, Stephan P.; Wenderoth, Nicole

2014-01-01

Neurodevelopmental disconnections have been assumed to cause behavioral alterations in autism spectrum disorders (ASDs). Here, we combined measurements of intrinsic functional connectivity (iFC) from resting-state functional magnetic resonance imaging (fMRI) with task-based fMRI to explore whether altered activity and/or iFC of the right posterior superior temporal sulcus (pSTS) mediates deficits in emotion recognition in ASD. Fifteen adults with ASD and 15 matched-controls underwent resting-state and task-based fMRI, during which participants discriminated emotional states from point light displays (PLDs). Intrinsic FC of the right pSTS was further examined using 584 (278 ASD/306 controls) resting-state data of the Autism Brain Imaging Data Exchange (ABIDE). Participants with ASD were less accurate than controls in recognizing emotional states from PLDs. Analyses revealed pronounced ASD-related reductions both in task-based activity and resting-state iFC of the right pSTS with fronto-parietal areas typically encompassing the action observation network (AON). Notably, pSTS-hypo-activity was related to pSTS-hypo-connectivity, and both measures were predictive of emotion recognition performance with each measure explaining a unique part of the variance. Analyses with the large independent ABIDE dataset replicated reductions in pSTS-iFC to fronto-parietal regions. These findings provide novel evidence that pSTS hypo-activity and hypo-connectivity with the fronto-parietal AON are linked to the social deficits characteristic of ASD. PMID:24078018

Relationship between Speech Production and Perception in People Who Stutter.

PubMed

Lu, Chunming; Long, Yuhang; Zheng, Lifen; Shi, Guang; Liu, Li; Ding, Guosheng; Howell, Peter

2016-01-01

Speech production difficulties are apparent in people who stutter (PWS). PWS also have difficulties in speech perception compared to controls. It is unclear whether the speech perception difficulties in PWS are independent of, or related to, their speech production difficulties. To investigate this issue, functional MRI data were collected on 13 PWS and 13 controls whilst the participants performed a speech production task and a speech perception task. PWS performed poorer than controls in the perception task and the poorer performance was associated with a functional activity difference in the left anterior insula (part of the speech motor area) compared to controls. PWS also showed a functional activity difference in this and the surrounding area [left inferior frontal cortex (IFC)/anterior insula] in the production task compared to controls. Conjunction analysis showed that the functional activity differences between PWS and controls in the left IFC/anterior insula coincided across the perception and production tasks. Furthermore, Granger Causality Analysis on the resting-state fMRI data of the participants showed that the causal connection from the left IFC/anterior insula to an area in the left primary auditory cortex (Heschl's gyrus) differed significantly between PWS and controls. The strength of this connection correlated significantly with performance in the perception task. These results suggest that speech perception difficulties in PWS are associated with anomalous functional activity in the speech motor area, and the altered functional connectivity from this area to the auditory area plays a role in the speech perception difficulties of PWS.

Distortion of time interval reproduction in an epileptic patient with a focal lesion in the right anterior insular/inferior frontal cortices.

PubMed

Monfort, Vincent; Pfeuty, Micha; Klein, Madelyne; Collé, Steffie; Brissart, Hélène; Jonas, Jacques; Maillard, Louis

2014-11-01

This case report on an epileptic patient suffering from a focal lesion at the junction of the right anterior insular cortex (AIC) and the adjacent inferior frontal cortex (IFC) provides the first evidence that damage to this brain region impairs temporal performance in a visual time reproduction task in which participants had to reproduce the presentation duration (3, 5 and 7s) of emotionally-neutral and -negative pictures. Strikingly, as compared to a group of healthy subjects, the AIC/IFC case considerably overestimated reproduction times despite normal variability. The effect was obtained in all duration and emotion conditions. Such a distortion in time reproduction was not observed in four other epileptic patients without insular or inferior frontal damage. Importantly, the absolute extent of temporal over-reproduction increased in proportion to the magnitude of the target durations, which concurs with the scalar property of interval timing, and points to an impairment of time-specific rather than of non temporal (such as motor) mechanisms. Our data suggest that the disability in temporal reproduction of the AIC/IFC case would result from a distorted memory representation of the encoded duration, occurring during the process of storage and/or of recovery from memory and leading to a deviation of the temporal judgment during the reproduction task. These findings support the recent proposal that the anterior insular/inferior frontal cortices would be involved in time interval representation. Copyright © 2014 Elsevier Ltd. All rights reserved.

Real-time Image Processing for Microscopy-based Label-free Imaging Flow Cytometry in a Microfluidic Chip.

PubMed

Heo, Young Jin; Lee, Donghyeon; Kang, Junsu; Lee, Keondo; Chung, Wan Kyun

2017-09-14

Imaging flow cytometry (IFC) is an emerging technology that acquires single-cell images at high-throughput for analysis of a cell population. Rich information that comes from high sensitivity and spatial resolution of a single-cell microscopic image is beneficial for single-cell analysis in various biological applications. In this paper, we present a fast image-processing pipeline (R-MOD: Real-time Moving Object Detector) based on deep learning for high-throughput microscopy-based label-free IFC in a microfluidic chip. The R-MOD pipeline acquires all single-cell images of cells in flow, and identifies the acquired images as a real-time process with minimum hardware that consists of a microscope and a high-speed camera. Experiments show that R-MOD has the fast and reliable accuracy (500 fps and 93.3% mAP), and is expected to be used as a powerful tool for biomedical and clinical applications.

Rethinking Role Play in the Reception Class

ERIC Educational Resources Information Center

Rogers, Sue; Evans, Julie

2007-01-01

Background: In 2000 the so-called "Reception" class was re-conceived (in curricular terms, at least) as the second and final year of the Foundation Stage, a distinctive educational phase for children aged 3 until entry to key stage 1 at 5 or 6 years old. The "Curriculum guidance for the Foundation Stage" endorses a play-based,…

Abnormal activation of the social brain during face perception in autism.

PubMed

Hadjikhani, Nouchine; Joseph, Robert M; Snyder, Josh; Tager-Flusberg, Helen

2007-05-01

ASD involves a fundamental impairment in processing social-communicative information from faces. Several recent studies have challenged earlier findings that individuals with autism spectrum disorder (ASD) have no activation of the fusiform gyrus (fusiform face area, FFA) when viewing faces. In this study, we examined activation to faces in the broader network of face-processing modules that comprise what is known as the social brain. Using 3T functional resonance imaging, we measured BOLD signal changes in 10 ASD subjects and 7 healthy controls passively viewing nonemotional faces. We replicated our original findings of significant activation of face identity-processing areas (FFA and inferior occipital gyrus, IOG) in ASD. However, in addition, we identified hypoactivation in a more widely distributed network of brain areas involved in face processing [including the right amygdala, inferior frontal cortex (IFC), superior temporal sulcus (STS), and face-related somatosensory and premotor cortex]. In ASD, we found functional correlations between a subgroup of areas in the social brain that belong to the mirror neuron system (IFC, STS) and other face-processing areas. The severity of the social symptoms measured by the Autism Diagnostic Observation Schedule was correlated with the right IFC cortical thickness and with functional activation in that area. When viewing faces, adults with ASD show atypical patterns of activation in regions forming the broader face-processing network and social brain, outside the core FFA and IOG regions. These patterns suggest that areas belonging to the mirror neuron system are involved in the face-processing disturbances in ASD.

Relationship between Speech Production and Perception in People Who Stutter

PubMed Central

Lu, Chunming; Long, Yuhang; Zheng, Lifen; Shi, Guang; Liu, Li; Ding, Guosheng; Howell, Peter

2016-01-01

Speech production difficulties are apparent in people who stutter (PWS). PWS also have difficulties in speech perception compared to controls. It is unclear whether the speech perception difficulties in PWS are independent of, or related to, their speech production difficulties. To investigate this issue, functional MRI data were collected on 13 PWS and 13 controls whilst the participants performed a speech production task and a speech perception task. PWS performed poorer than controls in the perception task and the poorer performance was associated with a functional activity difference in the left anterior insula (part of the speech motor area) compared to controls. PWS also showed a functional activity difference in this and the surrounding area [left inferior frontal cortex (IFC)/anterior insula] in the production task compared to controls. Conjunction analysis showed that the functional activity differences between PWS and controls in the left IFC/anterior insula coincided across the perception and production tasks. Furthermore, Granger Causality Analysis on the resting-state fMRI data of the participants showed that the causal connection from the left IFC/anterior insula to an area in the left primary auditory cortex (Heschl’s gyrus) differed significantly between PWS and controls. The strength of this connection correlated significantly with performance in the perception task. These results suggest that speech perception difficulties in PWS are associated with anomalous functional activity in the speech motor area, and the altered functional connectivity from this area to the auditory area plays a role in the speech perception difficulties of PWS. PMID:27242487

Exploring Possible Selves in a First-Year Physics Foundation Class: Engaging Students by Establishing Relevance

ERIC Educational Resources Information Center

Bennett, Dawn; Roberts, Lynne; Creagh, Christine

2016-01-01

Students often complain that they cannot see the relevance of what they are being taught in foundation physics classes. While revising and adjusting the curriculum and teaching are important, this study suggests it might also be useful to help students view their learning in relation to their future career aspirations. This paper reports on a…

Distinct Functional Connectivities Predict Clinical Response with Emotion Regulation Therapy

PubMed Central

Fresco, David M.; Roy, Amy K.; Adelsberg, Samantha; Seeley, Saren; García-Lesy, Emmanuel; Liston, Conor; Mennin, Douglas S.

2017-01-01

Despite the success of available medical and psychosocial treatments, a sizable subgroup of individuals with commonly co-occurring disorders, generalized anxiety disorder (GAD) and major depressive disorder (MDD), fail to make sufficient treatment gains thereby prolonging their deficits in life functioning and satisfaction. Clinically, these patients often display temperamental features reflecting heightened sensitivity to underlying motivational systems related to threat/safety and reward/loss (e.g., somatic anxiety) as well as inordinate negative self-referential processing (e.g., worry, rumination). This profile may reflect disruption in two important neural networks associated with emotional/motivational salience (e.g., salience network) and self-referentiality (e.g., default network, DN). Emotion Regulation Therapy (ERT) was developed to target this hypothesized profile and its neurobehavioral markers. In the present study, 22 GAD patients (with and without MDD) completed resting state MRI scans before receiving 16 sessions of ERT. To test study these hypotheses, we examined the associations between baseline patterns of intrinsic functional connectivity (iFC) of the insula and of hubs within the DN (anterior and dorsal medial prefrontal cortex [MPFC] and posterior cingulate cortex [PCC]) and treatment-related changes in worry, somatic anxiety symptoms and decentering. Results suggest that greater treatment linked reductions in worry were associated with iFC clusters in both the insular and parietal cortices. Greater treatment linked gains in decentering, a metacognitive process that involves the capacity to observe items that arise in the mind with healthy psychological distance that is targeted by ERT, was associated with iFC clusters in the anterior and posterior DN. The current study adds to the growing body of research implicating disruptions in the default and salience networks as promising targets of treatment for GAD with and without co-occurring MDD. PMID:28316567

Immunity-Based Aircraft Fault Detection System

NASA Technical Reports Server (NTRS)

Dasgupta, D.; KrishnaKumar, K.; Wong, D.; Berry, M.

2004-01-01

In the study reported in this paper, we have developed and applied an Artificial Immune System (AIS) algorithm for aircraft fault detection, as an extension to a previous work on intelligent flight control (IFC). Though the prior studies had established the benefits of IFC, one area of weakness that needed to be strengthened was the control dead band induced by commanding a failed surface. Since the IFC approach uses fault accommodation with no detection, the dead band, although it reduces over time due to learning, is present and causes degradation in handling qualities. If the failure can be identified, this dead band can be further A ed to ensure rapid fault accommodation and better handling qualities. The paper describes the application of an immunity-based approach that can detect a broad spectrum of known and unforeseen failures. The approach incorporates the knowledge of the normal operational behavior of the aircraft from sensory data, and probabilistically generates a set of pattern detectors that can detect any abnormalities (including faults) in the behavior pattern indicating unsafe in-flight operation. We developed a tool called MILD (Multi-level Immune Learning Detection) based on a real-valued negative selection algorithm that can generate a small number of specialized detectors (as signatures of known failure conditions) and a larger set of generalized detectors for unknown (or possible) fault conditions. Once the fault is detected and identified, an adaptive control system would use this detection information to stabilize the aircraft by utilizing available resources (control surfaces). We experimented with data sets collected under normal and various simulated failure conditions using a piloted motion-base simulation facility. The reported results are from a collection of test cases that reflect the performance of the proposed immunity-based fault detection algorithm.

A summary of microwave remote sensing investigations planned for BOREAS

NASA Technical Reports Server (NTRS)

Mcdonald, Kyle C.

1993-01-01

The Boreal Ecosystem - Atmosphere Study (BOREAS) is a multidisciplinary field and remote sensing study that will be implemented jointly by the United States and Canada. The goal of BOREAS is to obtain an improved understanding of the interactions between the boreal forest biome and the atmosphere in order to clarify their roles in global change. Specific objectives are to improve the understanding of the processes that govern the exchanges of water, energy, heat, carbon, and trace gases between boreal ecosystems and the atmosphere, and to develop and validate remote sensing algorithms for transferring the understanding of these processes from local to regional scales. Two principal field sites, both within Canada, were selected. The northern site is located near Thompson, Manitoba, and the southern site encompasses Prince Albert National Park in Saskatchewan. The growing season in the northern site tends to be limited by growing-degree days while the southern site is limited by soil moisture and fire frequency. Most of the field work will occur at these two sites during 1993 and 1994 as part of six field campaigns. The first of these campaigns is scheduled for August 1993 and will involve instrument installation and an operational shakedown. Three large scale Intensive Field Campaigns (IFC's) are scheduled for 1994, along with two smaller scale Focused Field Campaigns (FFC's). The first 1994 campaign will be an FFC designed to capture the biome under completely frozen conditions during the winter. The second FFC and the first IFC are scheduled to capture the spring thaw period. Another IFC will take place in the summer during a period of maximum water stress. Finally, the third FFC will be scheduled to capture the collapse into senescence during the fall.

Identification of the Transcriptional Targets of FOXP2, a Gene Linked to Speech and Language, in Developing Human Brain

PubMed Central

Spiteri, Elizabeth ; Konopka, Genevieve ; Coppola, Giovanni ; Bomar, Jamee ; Oldham, Michael ; Ou, Jing ; Vernes, Sonja C. ; Fisher, Simon E. ; Ren, Bing ; Geschwind, Daniel H. 

2007-01-01

Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the only known cause of developmental speech and language disorders in humans. To date, there are no known targets of human FOXP2 in the nervous system. The identification of FOXP2 targets in the developing human brain, therefore, provides a unique tool with which to explore the development of human language and speech. Here, we define FOXP2 targets in human basal ganglia (BG) and inferior frontal cortex (IFC) by use of chromatin immunoprecipitation followed by microarray analysis (ChIP-chip) and validate the functional regulation of targets in vitro. ChIP-chip identified 285 FOXP2 targets in fetal human brain; statistically significant overlap of targets in BG and IFC indicates a core set of 34 transcriptional targets of FOXP2. We identified targets specific to IFC or BG that were not observed in lung, suggesting important regional and tissue differences in FOXP2 activity. Many target genes are known to play critical roles in specific aspects of central nervous system patterning or development, such as neurite outgrowth, as well as plasticity. Subsets of the FOXP2 transcriptional targets are either under positive selection in humans or differentially expressed between human and chimpanzee brain. This is the first ChIP-chip study to use human brain tissue, making the FOXP2-target genes identified in these studies important to understanding the pathways regulating speech and language in the developing human brain. These data provide the first insight into the functional network of genes directly regulated by FOXP2 in human brain and by evolutionary comparisons, highlighting genes likely to be involved in the development of human higher-order cognitive processes. PMID:17999357

Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.

PubMed

Rubia, Katya; Alegria, Analucia A; Cubillo, Ana I; Smith, Anna B; Brammer, Michael J; Radua, Joaquim

2014-10-15

Psychostimulant medication, most commonly the catecholamine agonist methylphenidate, is the most effective treatment for attention-deficit/hyperactivity disorder (ADHD). However, relatively little is known on the mechanisms of action. Acute effects on brain function can elucidate underlying neurocognitive effects. We tested methylphenidate effects relative to placebo in functional magnetic resonance imaging (fMRI) during three disorder-relevant tasks in medication-naïve ADHD adolescents. In addition, we conducted a systematic review and meta-analysis of the fMRI findings of acute stimulant effects on ADHD brain function. The fMRI study compared 20 adolescents with ADHD under either placebo or methylphenidate in a randomized controlled trial while performing stop, working memory, and time discrimination tasks. The meta-analysis was conducted searching PubMed, ScienceDirect, Web of Knowledge, Google Scholar, and Scopus databases. Peak coordinates of clusters of significant effects of stimulant medication relative to placebo or off medication were extracted for each study. The fMRI analysis showed that methylphenidate significantly enhanced activation in bilateral inferior frontal cortex (IFC)/insula during inhibition and time discrimination but had no effect on working memory networks. The meta-analysis, including 14 fMRI datasets and 212 children with ADHD, showed that stimulants most consistently enhanced right IFC/insula activation, which also remained for a subgroup analysis of methylphenidate effects alone. A more lenient threshold also revealed increased putamen activation. Psychostimulants most consistently increase right IFC/insula activation, which are key areas of cognitive control and also the most replicated neurocognitive dysfunction in ADHD. These neurocognitive effects may underlie their positive clinical effects. © 2013 Society of Biological Psychiatry Published by Society of Biological Psychiatry All rights reserved.

Side-effects and technical problems in cytapheresis with cell separators. Results of a retrospective multicenter study.

PubMed

Kretschmer, V

1987-09-01

On the basis of a survey, the acute side-effects and technical problems in a total of 77,525 cytaphereses (IFC 36,530, CFC 40,995) in donors at 39 hemapheresis centers were retrospectively analysed statistically. In general, relevant donor side-effects (0.78%-1.05%) were more rare than the primary donor-independent disturbances (1.65%-2.63%). The donor side-effects predominated merely with the use of the cell separators Haemonetics M30/Belco (1.06% vs. 0.57%). These were mainly circulatory reactions (0.83%), which were generally much more frequent with IFC (0.54%) than with CFC (IBM/Cobe 0.11%, CS-3000 0.19%). Potentially fatal complications were not reported. The frequency of side-effects, disturbances and discontinuations correlated inversely with the separation rate of the individual centers per method. Centers in which two or three methods were applied simultaneously reported a higher frequency of side-effects and disturbances. Hemolysis was only observed with IFC (0.09%), but not with the use of the Haemonetics V50. The greater susceptibility to disturbances of technical/methodological/operational origin essentially results from the more elaborate, but not yet perfected technology, including computer control and monitoring, as well as defects in the production of the much more complicated disposable sets. Thus the highest rate of discontinuations was calculated for the system which is so far the most sophisticated technically (CS-3000, 1.85%). Although the primary donor-independent problems sometimes correlate directly with the manifestation of donor side-effects, the greater technological sophistication of automatically controlled and monitored systems cannot be dispensed with, since only in this way can potentially fatal risks for the donors be largely ruled out.(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of Stimulants on Brain Function in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis

PubMed Central

Rubia, Katya; Alegria, Analucia A.; Cubillo, Ana I.; Smith, Anna B.; Brammer, Michael J.; Radua, Joaquim

2014-01-01

Background Psychostimulant medication, most commonly the catecholamine agonist methylphenidate, is the most effective treatment for attention-deficit/hyperactivity disorder (ADHD). However, relatively little is known on the mechanisms of action. Acute effects on brain function can elucidate underlying neurocognitive effects. We tested methylphenidate effects relative to placebo in functional magnetic resonance imaging (fMRI) during three disorder-relevant tasks in medication-naïve ADHD adolescents. In addition, we conducted a systematic review and meta-analysis of the fMRI findings of acute stimulant effects on ADHD brain function. Methods The fMRI study compared 20 adolescents with ADHD under either placebo or methylphenidate in a randomized controlled trial while performing stop, working memory, and time discrimination tasks. The meta-analysis was conducted searching PubMed, ScienceDirect, Web of Knowledge, Google Scholar, and Scopus databases. Peak coordinates of clusters of significant effects of stimulant medication relative to placebo or off medication were extracted for each study. Results The fMRI analysis showed that methylphenidate significantly enhanced activation in bilateral inferior frontal cortex (IFC)/insula during inhibition and time discrimination but had no effect on working memory networks. The meta-analysis, including 14 fMRI datasets and 212 children with ADHD, showed that stimulants most consistently enhanced right IFC/insula activation, which also remained for a subgroup analysis of methylphenidate effects alone. A more lenient threshold also revealed increased putamen activation. Conclusions Psychostimulants most consistently increase right IFC/insula activation, which are key areas of cognitive control and also the most replicated neurocognitive dysfunction in ADHD. These neurocognitive effects may underlie their positive clinical effects. PMID:24314347

Fraternity at the Crossroads

ERIC Educational Resources Information Center

Dowiak, Shawn M.

2016-01-01

Are fraternities still relevant to the college student experience? By examining the moral, student, and leadership development of IFC fraternity men, while controlling for institutional and student characteristics, the current study analyzed the roots of the purported value-added nature of fraternities using data from the Multi-Institutional Study…

Deontological Dilemma Response Tendencies and Sensorimotor Representations of Harm to Others

PubMed Central

Christov-Moore, Leonardo; Conway, Paul; Iacoboni, Marco

2017-01-01

The dual process model of moral decision-making suggests that decisions to reject causing harm on moral dilemmas (where causing harm saves lives) reflect concern for others. Recently, some theorists have suggested such decisions actually reflect self-focused concern about causing harm, rather than witnessing others suffering. We examined brain activity while participants witnessed needles pierce another person’s hand, versus similar non-painful stimuli. More than a month later, participants completed moral dilemmas where causing harm either did or did not maximize outcomes. We employed process dissociation to independently assess harm-rejection (deontological) and outcome-maximization (utilitarian) response tendencies. Activity in the posterior inferior frontal cortex (pIFC) while participants witnessed others in pain predicted deontological, but not utilitarian, response tendencies. Previous brain stimulation studies have shown that the pIFC seems crucial for sensorimotor representations of observed harm. Hence, these findings suggest that deontological response tendencies reflect genuine other-oriented concern grounded in sensorimotor representations of harm. PMID:29311859

Low-level laser therapy and interferential current in patients with knee osteoarthritis: a randomized controlled trial protocol.

PubMed

Alqualo-Costa, Renata; Thomé, Gustavo R; Perracini, Mônica R; Liebano, Richard E

2018-05-03

The aim of this study is to investigate the effects of low-level laser therapy and interferential current (IFC) on pain intensity, central sensitization, muscle strength and functional capacity in patients with knee osteoarthritis. Participants will be patients aged between 50 and 80 years, with knee osteoarthritis, pain intensity ranging from 3 to 8 points (0-10 scale), Lequesne Algofunctional Index ranging from 5 to 15 points, and Kellgren & Lawrence grade ≥2. A total of 168 patients will be randomly allocated into four groups as follows: active IFC + laser sham (G1), IFC sham + active laser (G2), active IFC + laser (G3) and IFC + laser sham (G4). Evaluators will be blinded to group allocation. Primary outcomes will be pain at rest and during movement measured with the visual analog pain scale. Clinical Trials Registry (NCT02898025. Registered on 20 April 2016).

Extended Maptree: a Representation of Fine-Grained Topology and Spatial Hierarchy of Bim

NASA Astrophysics Data System (ADS)

Wu, Y.; Shang, J.; Hu, X.; Zhou, Z.

2017-09-01

Spatial queries play significant roles in exchanging Building Information Modeling (BIM) data and integrating BIM with indoor spatial information. However, topological operators implemented for BIM spatial queries are limited to qualitative relations (e.g. touching, intersecting). To overcome this limitation, we propose an extended maptree model to represent the fine-grained topology and spatial hierarchy of indoor spaces. The model is based on a maptree which consists of combinatorial maps and an adjacency tree. Topological relations (e.g., adjacency, incidence, and covering) derived from BIM are represented explicitly and formally by extended maptrees, which can facilitate the spatial queries of BIM. To construct an extended maptree, we first use a solid model represented by vertical extrusion and boundary representation to generate the isolated 3-cells of combinatorial maps. Then, the spatial relationships defined in IFC are used to sew them together. Furthermore, the incremental edges of extended maptrees are labeled as removed 2-cells. Based on this, we can merge adjacent 3-cells according to the spatial hierarchy of IFC.

The impact of blended learning on student performance in a cardiovascular pharmacotherapy course.

PubMed

McLaughlin, Jacqueline E; Gharkholonarehe, Nastaran; Khanova, Julia; Deyo, Zach M; Rodgers, Jo E

2015-03-25

To examine student engagement with, perception of, and performance resulting from blended learning for venous thromboembolism in a required cardiovascular pharmacotherapy course for second-year students. In 2013, key foundational content was packaged into an interactive online module for students to access prior to coming to class; class time was dedicated to active-learning exercises. Students who accessed all online module segments participated in more in class clicker questions (p=0.043) and performed better on the examination (p=0.023). There was no difference in clicker participation or examination performance based on time of module access (prior to or after class). The majority of participants agreed or strongly agreed that foundational content learned prior to class, applied activities during class, and content-related questions in the online module greatly enhanced learning. This study highlights the importance of integrating online modules with classroom learning and the role of blended learning in improving academic performance.

Foundational Aspects of Classroom Relations: Associations between Teachers' Immediacy Behaviours, Classroom Democracy, Class Identification and Learning

ERIC Educational Resources Information Center

Kwitonda, Jean Claude

2017-01-01

This study focused on foundational aspects of classroom relations. Specifically, relationships between teachers' immediacy (interpersonal) behaviours, classroom democracy, identification and learning were considered. Previous work suggests that these variables can be used as a foundation to shape classroom climate, culture and learning outcomes…

Detecting high-dimensional multipartite entanglement via some classes of measurements

NASA Astrophysics Data System (ADS)

Liu, Lu; Gao, Ting; Yan, Fengli

2018-02-01

Not Available Project supported by the National Natural Science Foundation of China (Grant Nos. 11371005 and 11475054) and the Natural Science Foundation of Hebei Province of China (Grant No. A2016205145).

75 FR 45013 - Pre-Existing Condition Insurance Plan Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-30

... provided (an important protection for a program designed to offer coverage to those with a pre-existing... Part II Department of Health and Human Services 45 CFR Part 152 Pre-Existing Condition Insurance... [OCIIO-9995-IFC] RIN 0991-AB71 Pre-Existing Condition Insurance Plan Program AGENCY: Office of Consumer...

Give Your Technology Program a Little "Class"!

ERIC Educational Resources Information Center

Vengersammy, Ormilla

2009-01-01

The Orange County Library System (OCLS) began to offer basic technology classes in July 2000. The computers were funded through a grant awarded by the Bill & Melinda Gates Foundation. Over time, the library staff noticed that the demand for the classes increased, so the offering of classes also increased. When the author arrived at OCLS, her…

Linking Classes: Learning Communities, "High" Culture, and the Working Class Student

ERIC Educational Resources Information Center

Rodriguez, Ginger G.; Buczinsky, Christopher

2013-01-01

How do you teach the humanities to working class students living in the shadow of a BP oil refinery? Calumet College uses freshman learning communities that link humanities, social justice, and English composition classes to provide a foundation for college success to predominantly first-generation students who are often underprepared for…

The impact of scienceware and foundations on students' attitudes towards science and science classes

NASA Astrophysics Data System (ADS)

Stratford, Steven J.; Finkel, Elizabeth A.

1996-03-01

In this paper, we describe changes in students' ideas about science classes, attitudes about science, and motivations for studying science, in a classroom designed to support projectbased science learing. Using a survey designed to provide a measure of students' attitudes towards science classes and science, we have compared students enrolled in a traditional high school biology course, with students enrolled in an integrated, project-based science course called Foundations I. Survey responses were analyzed to look at differences between and within two groups of students over the course of one school year. In general, the results of this study suggest that providing students with opportunities to collect and analyze their own data in science classes results in a change in students' ideas about science classrooms. Foundations I students' increased tendency to agree with statements about `using information,' `drawing conclusions,' and `thinking about problems,' implies a change in their understanding of what it means to do science in school. These students, in contrast to students in the traditional Biology course, no longer describe their science experience as one of memorization, textbook reading, and test taking. Instead they see science class as a place in which they can collect data, draw conclusions, and formulate and solve problems.

Home | The National Academies of Sciences, Engineering, and Medicine |

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Johnson Foundation Health Policy Fellows Logo Eight health professionals have been selected for the 2016 -2017 class of Robert Wood Johnson Foundation Health Policy Fellows at the National Academy of Medicine

On Non-Abelian Extensions of 3-Lie Algebras

NASA Astrophysics Data System (ADS)

Song, Li-Na; Makhlouf, Abdenacer; Tang, Rong

2018-04-01

In this paper, we study non-abelian extensions of 3-Lie algebras through Maurer-Cartan elements. We show that there is a one-to-one correspondence between isomorphism classes of non-abelian extensions of 3-Lie algebras and equivalence classes of Maurer-Cartan elements in a DGLA. The structure of the Leibniz algebra on the space of fundamental objects is also analyzed. Supported by National Natural Science Foundation of China under Grant No. 11471139 and National Natural Science Foundation of Jilin Province under Grant No. 20170101050JC

The Impact of Blended Learning on Student Performance in a Cardiovascular Pharmacotherapy Course

PubMed Central

McLaughlin, Jacqueline E.; Gharkholonarehe, Nastaran; Khanova, Julia; Deyo, Zach M.

2015-01-01

Objective. To examine student engagement with, perception of, and performance resulting from blended learning for venous thromboembolism in a required cardiovascular pharmacotherapy course for second-year students. Design. In 2013, key foundational content was packaged into an interactive online module for students to access prior to coming to class; class time was dedicated to active-learning exercises. Assessment. Students who accessed all online module segments participated in more in class clicker questions (p=0.043) and performed better on the examination (p=0.023). There was no difference in clicker participation or examination performance based on time of module access (prior to or after class). The majority of participants agreed or strongly agreed that foundational content learned prior to class, applied activities during class, and content-related questions in the online module greatly enhanced learning. Conclusion. This study highlights the importance of integrating online modules with classroom learning and the role of blended learning in improving academic performance. PMID:25861105

Congratulating the Pennsylvania State University IFC/Panhellenic Dance Marathon (THON) on its continued success in support of the Four Diamonds Fund at Penn State Hershey Children's Hospital.

THOMAS, 111th Congress

Rep. Thompson, Glenn [R-PA-5

2010-02-25

House - 03/22/2010 Referred to the Subcommittee on Higher Education, Lifelong Learning, and Competitiveness. (All Actions) Tracker: This bill has the status Agreed to in HouseHere are the steps for Status of Legislation:

Adaptive Control Law Development for Failure Compensation Using Neural Networks on a NASA F-15 Aircraft

NASA Technical Reports Server (NTRS)

Burken, John J.

2005-01-01

This viewgraph presentation covers the following topics: 1) Brief explanation of Generation II Flight Program; 2) Motivation for Neural Network Adaptive Systems; 3) Past/ Current/ Future IFCS programs; 4) Dynamic Inverse Controller with Explicit Model; 5) Types of Neural Networks Investigated; and 6) Brief example

Changing Medicaid and Intermediate Care Facilities for the Mentally Retarded (ICF/MR): Evaluation of Alternatives.

ERIC Educational Resources Information Center

Fernald, Charles Denton

1986-01-01

Some alternatives for changing IFC are evaluated, and a model that can be used for considering other alternatives is presented. Proposals include a system of treatment protocols for diagnosis-related groups and a revision of S.873, The Community and Family Living Amendments of 1985. (Author/CL)

Time-resolved fluorescence and FCS studies of dye-doped DNA

NASA Astrophysics Data System (ADS)

Nicolaou, N.; Marsh, R. J.; Blacker, T.; Armoogum, D. A.; Bain, A. J.

2009-08-01

Fluorescence lifetime, anisotropy and intensity dependent single molecule fluorescence correlation spectroscopy (I-FCS) are used to investigate the mechanism of fluorescence saturation in a free and nucleotide bound fluorophore (NR6104) in an antioxidising ascorbate buffer. Nucleotide attachment does not appreciably affect the fluorescence lifetime of the probe and there is a decrease in the rate of intersystem crossing relative to that of triplet state deactivation. The triplet state fraction is seen to plateau at 72% (G-attached) and 80% (free fluorophore) in agreement with these observations. Measurements of translational diffusion times show no intensity dependence for excitation intensities between 1 and 105kW cm-2 and photobleaching is therefore negligible. The dominant mechanism of fluorescence saturation is thus triplet state formation. I-FCS measurements for Rhodamine 6G in water were compared with those in the ascorbate buffer. In water the triplet fraction was saturated at considerably higher powers (45% at ca. 1.5 × 103kW cm-2) than in the ascorbate buffer (55%ca. 1 1kW cm-2)

Integrated Food Chain Surveillance System for Salmonella spp. in Mexico1

PubMed Central

Calva, Juan Jose; Estrada-Garcia, Maria Teresa; Leon, Veronica; Vazquez, Gabriela; Figueroa, Gloria; Lopez, Estela; Contreras, Jesus; Abbott, Jason; Zhao, Shaohua; McDermott, Patrick; Tollefson, Linda

2008-01-01

Few developing countries have foodborne pathogen surveillance systems, and none of these integrates data from humans, food, and animals. We describe the implementation of a 4-state, integrated food chain surveillance system (IFCS) for Salmonella spp. in Mexico. Significant findings were 1) high rates of meat contamination (21.3%–36.4%), 2) high rates of ceftriaxone-resistant S. Typhimurium in chicken, ill humans, and swine (77.3%, 66.3%, and 40.4% of S. Typhimurium T isolates, respectively), and 3) the emergence of ciprofloxacin resistance in S. Heidelberg (10.4%) and S. Typhimurium (1.7%) from swine. A strong association between Salmonella spp. contamination in beef and asymptomatic Salmonella spp. infection was only observed in the state with the lowest poverty level (Pearson r = 0.91, p<0.001). Pulsed-field gel electrophoresis analysis of 311 S. Typhimurium isolates showed 14 clusters with 102 human, retail meat, and food-animal isolates with indistinguishable patterns. An IFCS is technically and economically feasible in developing countries and can effectively identify major public health priorities. PMID:18325258

BOREAS AFM-2 King Air 1994 Aircraft Flux and Moving Window Data

NASA Technical Reports Server (NTRS)

Kelly, Robert D.; Hall, Forrest G. (Editor); Newcomer, Jeffrey A. (Editor); Smith, David E. (Technical Monitor)

2000-01-01

The BOREAS AFM-2 team collected pass-by-pass fluxes (and many other statistics) for a large number of level (constant altitude), straight-line passes used in a variety of flight patterns. The data were collected by the University of Wyoming King Air in 1994 BOREAS IFCs 1-3. Most of these data were collected at 60-70 m above ground level, but a significant number of passes were also flown at various levels in the planetary boundary layer, up to about the inversion height. This documentation concerns only the data from the straight and level passes that are presented as original (over the NSA and SSA) and moving window values (over the Transect). Another archive of King Air data is also available, containing data from all the soundings flown by the King Air 1994 IFCs 1-3. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884) or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Characteristics of Instructional Videos

ERIC Educational Resources Information Center

Beheshti, Mobina; Taspolat, Ata; Kaya, Omer Sami; Sapanca, Hamza Fatih

2018-01-01

Nowadays, video plays a significant role in education in terms of its integration into traditional classes, the principal delivery system of information in classes particularly in online courses as well as serving as a foundation of many blended classes. Hence, education is adopting a modern approach of instruction with the target of moving away…

Global screening for Critical Habitat in the terrestrial realm

PubMed Central

Blyth, Simon; Bennun, Leon; Butchart, Stuart H. M.; Hoffmann, Michael; Burgess, Neil D.; Cuttelod, Annabelle; Jones, Matt I.; Kapos, Val; Pilgrim, John; Tolley, Melissa J.; Underwood, Emma C.; Weatherdon, Lauren V.

2018-01-01

Critical Habitat has become an increasingly important concept used by the finance sector and businesses to identify areas of high biodiversity value. The International Finance Corporation (IFC) defines Critical Habitat in their highly influential Performance Standard 6 (PS6), requiring projects in Critical Habitat to achieve a net gain of biodiversity. Here we present a global screening layer of Critical Habitat in the terrestrial realm, derived from global spatial datasets covering the distributions of 12 biodiversity features aligned with guidance provided by the IFC. Each biodiversity feature is categorised as ‘likely’ or ‘potential’ Critical Habitat based on: 1. Alignment between the biodiversity feature and the IFC Critical Habitat definition; and 2. Suitability of the spatial resolution for indicating a feature’s presence on the ground. Following the initial screening process, Critical Habitat must then be assessed in-situ by a qualified assessor. This analysis indicates that a total of 10% and 5% of the global terrestrial environment can be considered as likely and potential Critical Habitat, respectively, while the remaining 85% did not overlap with any of the biodiversity features assessed and was classified as ‘unknown’. Likely Critical Habitat was determined principally by the occurrence of Key Biodiversity Areas and Protected Areas. Potential Critical Habitat was predominantly characterised by data representing highly threatened and unique ecosystems such as ever-wet tropical forests and tropical dry forests. The areas we identified as likely or potential Critical Habitat are based on the best available global-scale data for the terrestrial realm that is aligned with IFC’s Critical Habitat definition. Our results can help businesses screen potential development sites at the early project stage based on a range of biodiversity features. However, the study also demonstrates several important data gaps and highlights the need to incorporate new and improved global spatial datasets as they become available. PMID:29565977

Comparison of complementary feeding strategies to meet zinc requirements of older breastfed infants1234

PubMed Central

Krebs, Nancy F; Westcott, Jamie E; Culbertson, Diana L; Sian, Lei; Miller, Leland V; Hambidge, K Michael

2012-01-01

Background: The low zinc intake from human milk at ∼6 mo of age predicts the dependence on complementary foods (CF) to meet the zinc requirements of older breastfed-only infants. Objective: The objective of this study was to compare major variables of zinc homeostasis and zinc status in 9-mo-old breastfed infants who were randomly assigned to different complementary food regimens. Design: Forty-five exclusively breastfed 5-mo-old infants were randomly assigned to receive commercially available pureed meats, iron-and-zinc–fortified infant cereal (IZFC), or whole-grain, iron-only–fortified infant cereal (IFC) as the first and primary CF until completion of zinc metabolic studies between 9 and 10 mo of age. A zinc stable-isotope methodology was used to measure the fractional absorption of zinc (FAZ) in human milk and CF by dual-isotope ratios in urine. Calculated variables included the dietary intake from duplicate diets and 4-d test weighing, the total absorbed zinc (TAZ) from FAZ × diet zinc, and the exchangeable zinc pool size (EZP) from isotope enrichment in urine. Results: Mean daily zinc intakes were significantly greater for the meat and IZFC groups than for the IFC group (P < 0.001); only intakes in meat and IZFC groups met estimated average requirements. Mean (±SEM) TAZ amounts were 0.80 ± 0.08, 0.71 ± 0.09, and 0.52 ± 0.05 mg/d for the meat, IZFC, and IFC groups, respectively (P = 0.027). Zinc from human milk contributed <25% of TAZ for all groups. The EZP correlated with both zinc intake (r = 0.43, P < 0.01) and TAZ (r = 0.54, P < 0.001). Conclusion: Zinc requirements for older breastfed-only infants are unlikely to be met without the regular consumption of either meats or zinc-fortified foods. PMID:22648720

Differential coding of hyperalgesia in the human brain: a functional MRI study.

PubMed

Maihöfner, Christian; Handwerker, Hermann O

2005-12-01

Neuropathic pain can be both ongoing or stimulus-induced. Stimulus-induced pain, also known as hyperalgesia, can be differentiated into primary and secondary hyperalgesia. The former results from sensitization of peripheral nociceptive structures, the latter involves sensitization processes within the central nervous system (CNS). Hypersensitivity towards heat stimuli, i.e. thermal hyperalgesia, is a key feature of primary hyperalgesia, whereas secondary hyperalgesia is characterized by hypersensitivity towards mechanical (e.g. pin-prick) stimulation. Using functional magnetic resonance imaging (fMRI), we investigated if brain activation patterns associated with primary and secondary hyperalgesia might differ. Thermal and pin-prick hyperalgesia were induced on the left forearm in 12 healthy subjects by topical capsaicin (2.5%, 30 min) application. Equal pain intensities of both hyperalgesia types were applied during fMRI experiments, based on previous quantitative sensory testing. Simultaneously, subjects had to rate the unpleasantness of stimulus-related pain. Pin-prick hyperalgesia (i.e. subtraction of brain activations during pin-prick stimulation before and after capsaicin exposure) led to activations of primary and secondary somatosensory cortices (S1 and S2), associative-somatosensory cortices, insula and superior and inferior frontal cortices (SFC, IFC). Brain areas activated during thermal hyperalgesia (i.e. subtraction of brain activations during thermal stimulation before and after capsaicin exposure) were S1 and S2, insula, associative-somatosensory cortices, cingulate cortex (GC), SFC, middle frontal cortex (MFC) and IFC. When compared to pin-prick hyperalgesia, thermal hyperalgesia led to an increased activation of bilateral anterior insular cortices, MFC, GC (Brodmann area 24' and 32') and contralateral SFC and IFC, despite equal pain intensities. Interestingly, stronger activations of GC, contralateral MFC and anterior insula significantly correlated to higher ratings of the stimulus-related unpleasantness. We conclude that thermal and mechanical hyperalgesia produce substantially different brain activation patterns. This is linked to different psychophysical properties.

Analysis of SSN 688 Class Submarine Maintenance Delays

DTIC Science & Technology

2017-06-01

Simplified Notional Submarine FRP (Independent Deployer) ..................11  Figure 8.  Evolution of Los Angeles Class Submarine Notional...Number TFP Technical Foundation Paper URO Unrestricted Operations xv ACKNOWLEDGMENTS I would like to thank my lead advisor, Professor Nick Dew...only on Los Angeles (SSN 688)-class submarines. Being the higher quantity and older generation submarine hull type, the Los Angeles class submarine

A resolution congratulating the Pennsylvania State University IFC/Panhellenic Dance Marathon ("THON") on its continued success in support of the Four Diamonds Fund at Penn State Hershey Children's Hospital.

THOMAS, 112th Congress

Sen. Casey, Robert P., Jr. [D-PA

2011-03-29

Senate - 03/30/2011 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

77 FR 28788 - Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Under the Patient Protection and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES 45 CFR Part 158 [CMS-9998-IFC3] Health Insurance Issuers..., entitled ``Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient...) requirements for health insurance issuers under section 2718 of the Public Health Service Act, as added by the...

Internet FAQ Archives - Online Education - faqs.org

Science.gov Websites

faqs.org Internet FAQ Archives - Online Education faqs.org faqs.org - Internet FAQ Archives Internet FAQ Archives Online Education Internet RFC Index Usenet FAQ Index Other FAQs Documents Tools IFC Rated FAQs Internet RFC/STD/FYI/BCP Archives The Internet RFC series of documents is also available from

Translanguaging in a Reading Class

ERIC Educational Resources Information Center

Vaish, Viniti; Subhan, Aidil

2015-01-01

Using translanguaging as a theoretical foundation, this paper analyses findings from a Grade 2 reading class for low achieving students, where Malay was used as a scaffold to teach English. Data come from one class in one school in Singapore and its Learning Support Programme (LSP), which is part of a larger research project on biliteracy. The LSP…

Theoretical Foundations for Website Design Courses.

ERIC Educational Resources Information Center

Walker, Kristin

2002-01-01

Considers how theoretical foundations in website design courses can facilitate students learning the genres of Internet communication. Proposes ways that theories can be integrated into website design courses. Focuses on two students' website portfolios and ways they utilize genre theory and activity theory discussed in class to produce websites…

Teaching Students Who Stutter

ERIC Educational Resources Information Center

Education Digest: Essential Readings Condensed for Quick Review, 2011

2011-01-01

Stutterer's incident in class draws national attention; Stuttering Foundation responds with tips for educators. In response to the articles in the "New York Times," Jane Fraser, president of the nonprofit Stuttering Foundation, wrote in a press release eight tips for educators regarding working with students who stutter. This article presents…

Better Thinking and Clearer Communication Will Help Special Education

ERIC Educational Resources Information Center

Kauffman, James M.; Badar, Jeanmarie

2014-01-01

The authors argue that insufficient attention has been given to foundational concepts in special education. Two classes of foundational concepts are discussed: human constructions and logico-mathematical facts. Four human constructions are examined: (1) making teaching most important, (2) discriminating among ideas, (3) choosing conceptual models,…

World wide IFC phosphoric acid fuel cell implementation

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, J.M. Jr

1996-04-01

International Fuel Cells, a subsidary of United technologies Corporation, is engaged in research and development of all types of fuel cell technologies and currently manufactures alkaline fuel cell power plants for the U.S. manned space flight program and natural gas fueled stationary power plants using phosphoric acid fuel cells. This paper describes the phosphoric acid fuel cell power plants.

A resolution congratulating the Pennsylvania State University IFC/Panhellenic Dance Marathon ("THON") on its continued success in support of the Four Diamonds Fund at Penn State Hershey Children's Hospital.

THOMAS, 113th Congress

Sen. Casey, Robert P., Jr. [D-PA

2014-03-11

Senate - 03/11/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

IFC BIM-Based Methodology for Semi-Automated Building Energy Performance Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bazjanac, Vladimir

2008-07-01

Building energy performance (BEP) simulation is still rarely used in building design, commissioning and operations. The process is too costly and too labor intensive, and it takes too long to deliver results. Its quantitative results are not reproducible due to arbitrary decisions and assumptions made in simulation model definition, and can be trusted only under special circumstances. A methodology to semi-automate BEP simulation preparation and execution makes this process much more effective. It incorporates principles of information science and aims to eliminate inappropriate human intervention that results in subjective and arbitrary decisions. This is achieved by automating every part ofmore » the BEP modeling and simulation process that can be automated, by relying on data from original sources, and by making any necessary data transformation rule-based and automated. This paper describes the new methodology and its relationship to IFC-based BIM and software interoperability. It identifies five steps that are critical to its implementation, and shows what part of the methodology can be applied today. The paper concludes with a discussion of application to simulation with EnergyPlus, and describes data transformation rules embedded in the new Geometry Simplification Tool (GST).« less

BOREAS TE-5 CO2 Concentration and Stable Isotope Composition

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Ehleriinger, Jim; Brooks, J. Renee; Flanagan, Larry

2000-01-01

The BOREAS TE-5 team collected measurements in the NSA and SSA on gas exchange, gas composition, and tree growth. This data set contains measurements of the concentration and stable carbon (C-13/C-12 and oxygen (O-18/O-16) isotope ratios of atmospheric CO2 in air samples collected at different heights within forest canopies. The data were collected to determine the influence of photosynthesis and respiration by the forest ecosystems on the concentration and stable isotope ratio of atmospheric CO2 These measurements were collected at the SSA during each 1994 IFC at OJP, OBS, and OA sites. Measurements were also collected at the NSA during each 1994 IFC at the OJP, T6R5S TE UBS, and T2Q6A TE OA sites. The stable isotope ratios are expressed using standard delta notation and in units of per mil. The isotope ratios are expressed relative to the international standard, PDB, for both carbon and oxygen samples. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Activity Archive Center (DAAC).

BOREAS TE-9 NSA Leaf Chlorophyll Density

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Margolis, Hank; Sy, Mikailou

2000-01-01

The BOREAS TE-9 team collected several data sets related to chemical and photosynthetic properties of leaves in boreal forest tree species. These data were collected to help provide an explanation of potential seasonal and spatial changes of leaf pigment properties in boreal forest species at the NSA. At different dates (FFC-Winter, FFC-Thaw, IFC-1, IFC-2, and IMC-3), foliage samples were collected from the upper third of the canopy for five NSA sites (YJP, OJP, OBS, UBS, and OA) near Thompson, Manitoba. Subsamples of 100 needles for black spruce, 20 needles for jack pine, and single leaf for trembling aspen were cut into pieces and immersed in a 20-mL DMF aliquot in a Nalgene test tube. The extracted foliage materials were then oven-dried at 68 C for 48 hours and weighed. Extracted leaf dry weight was converted to a total leaf area basis to express the chlorophyll content in mg/sq cm of total leaf area. The data are provided in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Aerosol optical properties over the midcontinental United States

NASA Technical Reports Server (NTRS)

Halthore, Rangasayi N.; Markham, Brian L.; Ferrare, Richard A.; Aro, Theo. O.

1992-01-01

Solar and sky radiation measurements were analyzed to obtain aerosol properties such as the optical thickness and the size distribution. The measurements were conducted as part of the First International Satellite Land Surface Climatology Project Field Experiment during the second intensive field campaign (IFC) from June 25 to July 14, 1987, and the fifth IFC from July 25 to August 12, 1989, on the Konza Prairie near Manhattan, Kansas. Correlations with climatological and meteorological parameters show that during the period of observations in 1987, two types of air masses dominated the area: an air mass with low optical thickness and low temperature air associated with a northerly breeze, commonly referred to as the continental air, and an air mass with a higher optical thickness and higher temperature air associated with a southerly wind which we call 'Gulf air'. The size distributions show a predominance of the larger size particles in 'Gulf air'. Because of the presence of two contrasting air masses, correlations with parameters such as relative humidity, specific humidity, pressure, temperature, and North Star sky radiance reveal some interesting aspects. In 1989, clear distinctions between continental and Gulf air cannot be made; the reason for this will be discussed.

Direct observation of melted Mott state evidenced from Raman scattering in 1T-TaS2 single crystal

NASA Astrophysics Data System (ADS)

Hu, Qing; Yin, Cong; Zhang, Leilei; Lei, Li; Wang, Zhengshang; Chen, Zhiyu; Tang, Jun; Ang, Ran

2018-01-01

Not Available Project supported by the National Natural Science Foundation of China (Grant Nos. 51771126 and 11774247), the Youth Foundation of Science and Technology Department of Sichuan Province, China (Grant No. 2016JQ0051), and the World First-Class University Construction Funding.

Autobiography, Disclosure, and Engaged Pedagogy: Toward a Practical Discussion on Teaching Foundations in Teacher Education Programs

ERIC Educational Resources Information Center

Milam, Jennifer L.; Jupp, James C.; Hoyt, Mei Wu; Kaufman, Mitzi; Grumbein, Matthew; O'Malley, Michael P.; Carpenter, B. Stephen, II; Slattery, Patrick

2014-01-01

In this research reflection, we develop a portrait of our engaged pedagogy for teaching educational foundations classes in teacher education. Our engaged pedagogy--based on autobiography and self-disclosure traditions-- emphasizes instructors and students' self-disclosure of lived experiences as being central to practical curriculum in teaching…

Utilizing Video Conferencing to Introduce an International Perspective to Foundation Practice

ERIC Educational Resources Information Center

Forgey, Mary Ann; Loughran, Hilda; Hansen, Johna

2013-01-01

Video conferencing has much potential to enrich international social work education. In this educational initiative, video conferencing was used to deliver a joint foundation social work practice class to students attending an MSW degree program both in the United States and in Ireland. Student feedback indicated that they gained an appreciation…

Change and Sustain/Ability: A Program Director's Reflections on Institutional Learning

ERIC Educational Resources Information Center

Asera, Rose

2008-01-01

Strengthening Pre-collegiate Education in Community Colleges (SPECC) was organized by The Carnegie Foundation for the Advancement of Teaching in partnership with The William and Flora Hewlett Foundation to increase student learning in developmental--or basic skills--classes. However, their concern was not just the success of students in classes…

Action Foundations! a Comic (Book) Tale of Defending Educational Studies

ERIC Educational Resources Information Center

Nuñez, Isabel; Konkol, Pamela J.

2013-01-01

When defending educational foundations, Isabel Nunez and Pamela Konkol sometimes find themselves responding to the question of "why?"-often phrased, "But WHYYYYY do we have to take a class on this stuff??? (We want to take more methods!)." As distressing as this can be for teacher educators whose own work reveals rather a…

Why the American Public Supports Twenty-First Century Learning

ERIC Educational Resources Information Center

Sacconaghi, Michele

2006-01-01

American attitudes toward the need for teaching twenty-first century skills appear as strong as the socioeconomic research being done that shows how critical these skills are for students' future access to the middle class and the country's economic competitiveness. In 2003, the AOL Time Warner Foundation (now the Time Warner Foundation) set out…

76 FR 36938 - National Science Board; Sunshine Act Meetings; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-23

... NATIONAL SCIENCE FOUNDATION National Science Board; Sunshine Act Meetings; Notice The National Science Board's ad hoc Committee on Nominations for the NSB Class of 2012--2018, pursuant to NSF regulations (45 CFR part 614), the National Science Foundation Act, as amended (42 U.S.C. 1862n- 5), and the...

Flight and Operational Medicine Clinic (FOMC) Workflow Analysis

DTIC Science & Technology

2014-03-14

Flight Medicine, Optometry, and Dental ) Base 4 MSME schedules all appointments required in the IFC (i.e., Flight Medicine, Optometry, and Dental ...IT Note: Base 1 Examinee completes Optometry, Dental , and Immunizations on the day of the Flight Medicine appointment Base 2 Examinee...completes Optometry and Immunizations prior to being seen in Flight Medicine Base 4 Examinee completes Optometry, Dental , and Immunizations on the day of

Iowa Flood Information System: Towards Integrated Data Management, Analysis and Visualization

NASA Astrophysics Data System (ADS)

Demir, I.; Krajewski, W. F.; Goska, R.; Mantilla, R.; Weber, L. J.; Young, N.

2012-04-01

The Iowa Flood Information System (IFIS) is a web-based platform developed by the Iowa Flood Center (IFC) to provide access to flood inundation maps, real-time flood conditions, flood forecasts both short-term and seasonal, flood-related data, information and interactive visualizations for communities in Iowa. The key element of the system's architecture is the notion of community. Locations of the communities, those near streams and rivers, define basin boundaries. The IFIS provides community-centric watershed and river characteristics, weather (rainfall) conditions, and streamflow data and visualization tools. Interactive interfaces allow access to inundation maps for different stage and return period values, and flooding scenarios with contributions from multiple rivers. Real-time and historical data of water levels, gauge heights, and rainfall conditions are available in the IFIS by streaming data from automated IFC bridge sensors, USGS stream gauges, NEXRAD radars, and NWS forecasts. Simple 2D and 3D interactive visualizations in the IFIS make the data more understandable to general public. Users are able to filter data sources for their communities and selected rivers. The data and information on IFIS is also accessible through web services and mobile applications. The IFIS is optimized for various browsers and screen sizes to provide access through multiple platforms including tablets and mobile devices. The IFIS includes a rainfall-runoff forecast model to provide a five-day flood risk estimate for around 500 communities in Iowa. Multiple view modes in the IFIS accommodate different user types from general public to researchers and decision makers by providing different level of tools and details. River view mode allows users to visualize data from multiple IFC bridge sensors and USGS stream gauges to follow flooding condition along a river. The IFIS will help communities make better-informed decisions on the occurrence of floods, and will alert communities in advance to help minimize damage of floods. This presentation provides an overview and live demonstration of the tools and interfaces in the IFIS developed to date to provide a platform for one-stop access to flood related data, visualizations, flood conditions, and forecast.

Iowa Flood Information System

NASA Astrophysics Data System (ADS)

Demir, I.; Krajewski, W. F.; Goska, R.; Mantilla, R.; Weber, L. J.; Young, N.

2011-12-01

The Iowa Flood Information System (IFIS) is a web-based platform developed by the Iowa Flood Center (IFC) to provide access to flood inundation maps, real-time flood conditions, flood forecasts both short-term and seasonal, flood-related data, information and interactive visualizations for communities in Iowa. The key element of the system's architecture is the notion of community. Locations of the communities, those near streams and rivers, define basin boundaries. The IFIS provides community-centric watershed and river characteristics, weather (rainfall) conditions, and streamflow data and visualization tools. Interactive interfaces allow access to inundation maps for different stage and return period values, and flooding scenarios with contributions from multiple rivers. Real-time and historical data of water levels, gauge heights, and rainfall conditions are available in the IFIS by streaming data from automated IFC bridge sensors, USGS stream gauges, NEXRAD radars, and NWS forecasts. Simple 2D and 3D interactive visualizations in the IFIS make the data more understandable to general public. Users are able to filter data sources for their communities and selected rivers. The data and information on IFIS is also accessible through web services and mobile applications. The IFIS is optimized for various browsers and screen sizes to provide access through multiple platforms including tablets and mobile devices. The IFIS includes a rainfall-runoff forecast model to provide a five-day flood risk estimate for around 500 communities in Iowa. Multiple view modes in the IFIS accommodate different user types from general public to researchers and decision makers by providing different level of tools and details. River view mode allows users to visualize data from multiple IFC bridge sensors and USGS stream gauges to follow flooding condition along a river. The IFIS will help communities make better-informed decisions on the occurrence of floods, and will alert communities in advance to help minimize damage of floods. This presentation provides an overview of the tools and interfaces in the IFIS developed to date to provide a platform for one-stop access to flood related data, visualizations, flood conditions, and forecast.

Flood Risk Management in Iowa through an Integrated Flood Information System

NASA Astrophysics Data System (ADS)

Demir, Ibrahim; Krajewski, Witold

2013-04-01

The Iowa Flood Information System (IFIS) is a web-based platform developed by the Iowa Flood Center (IFC) to provide access to flood inundation maps, real-time flood conditions, flood forecasts both short-term and seasonal, flood-related data, information and interactive visualizations for communities in Iowa. The key element of the system's architecture is the notion of community. Locations of the communities, those near streams and rivers, define basin boundaries. The IFIS provides community-centric watershed and river characteristics, weather (rainfall) conditions, and streamflow data and visualization tools. Interactive interfaces allow access to inundation maps for different stage and return period values, and flooding scenarios with contributions from multiple rivers. Real-time and historical data of water levels, gauge heights, and rainfall conditions are available in the IFIS by streaming data from automated IFC bridge sensors, USGS stream gauges, NEXRAD radars, and NWS forecasts. Simple 2D and 3D interactive visualizations in the IFIS make the data more understandable to general public. Users are able to filter data sources for their communities and selected rivers. The data and information on IFIS is also accessible through web services and mobile applications. The IFIS is optimized for various browsers and screen sizes to provide access through multiple platforms including tablets and mobile devices. The IFIS includes a rainfall-runoff forecast model to provide a five-day flood risk estimate for around 1100 communities in Iowa. Multiple view modes in the IFIS accommodate different user types from general public to researchers and decision makers by providing different level of tools and details. River view mode allows users to visualize data from multiple IFC bridge sensors and USGS stream gauges to follow flooding condition along a river. The IFIS will help communities make better-informed decisions on the occurrence of floods, and will alert communities in advance to help minimize damage of floods. This presentation provides an overview and live demonstration of the tools and interfaces in the IFIS developed to date to provide a platform for one-stop access to flood related data, visualizations, flood conditions, and forecast.

Towards a class library for mission planning

NASA Technical Reports Server (NTRS)

Pujo, Oliver; Smith, Simon T.; Starkey, Paul; Wolff, Thilo

1994-01-01

The PASTEL Mission Planning System (MPS) has been developed in C++ using an object-oriented (OO) methodology. While the scope and complexity of this system cannot compare to that of an MPS for a complex mission one of the main considerations of the development was to ensure that we could reuse some of the classes in future MPS. We present here PASTEL MPS classes which could be used in the foundations of a class library for MPS.

Shrinking Your Class

ERIC Educational Resources Information Center

Herron-Thorpe, Farren L.; Olson, Jo Clay; Davis, Denny

2010-01-01

Toys in the classroom was the result of a National Science Foundation grant that brought two engineering graduate students to a middle school math class. The graduate students and teachers collaborated in an effort to enhance students' mathematical learning. An engineering context was theorized as a way to further develop students' understanding…

Teaching Gender and Sexuality Diversity in Foundations of Education Courses in the US

ERIC Educational Resources Information Center

O'Malley, Michael; Hoyt, Mei; Slattery, Patrick

2009-01-01

This article is a summary of comprehensive units on gender and sexuality diversity that the authors have used in teacher education courses in undergraduate and graduate social foundations of education classes over several years. The course lesson plan includes a five-part analysis of the following categories: biological sex; gender identity/sexual…

"Staying Alive": Intellectual and Spiritual Sustenance on the Journey for Critical Foundations Scholars-Teachers.

ERIC Educational Resources Information Center

Brosio, Richard

This paper is a description and discussion of the author, a critical Social Foundations scholar-teacher, and the craft/intellectual/emotional/moral/identity sources that sustain his work. Opening paragraphs describe his family background in the Piedmont province of northern Italy, the Turin (Italy) working class and their attitudes toward work.…

Nine Ways to Catch Kids up

ERIC Educational Resources Information Center

Burns, Marilyn

2007-01-01

Through her work as a consultant, Burns has found that a handful of students in all classes lack an adequate foundation in basic math concepts and lag far behind their peers in both understanding and skills. Students who lack a foundation on which to build new learning are generally not well served even by well-planned, differentiated instruction;…

Student Perceptions of a Flipped Pharmacotherapy Course

PubMed Central

Khanova, Julia; McLaughlin, Jacqueline E.; Rhoney, Denise H.; Roth, Mary T.

2015-01-01

Objective. To evaluate student perception of the flipped classroom redesign of a required pharmacotherapy course. Design. Key foundational content was packaged into interactive, text-based online modules for self-paced learning prior to class. Class time was used for active and applied—but primarily case-based—learning. Assessment. For students with a strong preference for traditional lecture learning, the perception of the learning experience was negatively affected by the flipped course design. Module length and time required to complete preclass preparation were the most frequently cited impediments to learning. Students desired instructor-directed reinforcement of independently acquired knowledge to connect foundational knowledge and its application. Conclusion. This study illustrates the challenges and highlights the importance of designing courses to effectively balance time requirements and connect preclass and in-class learning activities. It underscores the crucial role of the instructor in bridging the gap between material learned as independent study and its application. PMID:26839429

Complete genome sequence of Anaeromyxobacter sp. Fw109-5, an Anaerobic, Metal-Reducing Bacterium Isolated from a Contaminated Subsurface Environment

DOE PAGES

Hwang, C.; Copeland, A.; Lucas, Susan; ...

2015-01-22

We report the genome sequence of Anaeromyxobacter sp. Fw109-5, isolated from nitrate- and uranium-contaminated subsurface sediment of the Oak Ridge Integrated Field-Scale Subsurface Research Challenge (IFC) site, Oak Ridge Reservation, TN. The bacterium’s genome sequence will elucidate its physiological potential in subsurface sediments undergoing in situ uranium bioremediation and natural attenuation.

Conflict and inhibition differentially affect the N200/P300 complex in a combined go/nogo and stop-signal task.

PubMed

Enriquez-Geppert, Stefanie; Konrad, Carsten; Pantev, Christo; Huster, René J

2010-06-01

Conflict and inhibition are considered to exert strong influences on the neurophysiological N200 and P300 brain responses as evoked in go/nogo and stop-signal tasks. In order to separate their underlying neural and functional mechanisms, the current experiment manipulated both conflict and inhibition. To do so, the go/nogo and stop-signal tasks were merged into one paradigm. Conflict was manipulated by varying go-trial frequencies across blocks (75% vs. 25%). Motor inhibition was manipulated by using go, nogo and stop trials each representing a different load of inhibition. Event-related potentials (ERPs) as well as current density reconstructions (CDRs) of fifteen healthy participants were analyzed. Overall, infrequent trials evoked significantly more pronounced N200s than frequent trials. The P300 predominantly revealed significant variations between trial types (go, nogo, stop). Estimated source activations of the MCC and the IFC supported the ERP results; N200-related effects were revealed in both regions, whereas the condition-specific variations of the P300 were only observed in the IFC. The results indicate that the N200 primarily reflects conflict-related effects whereas the P300 predominantly represents motor inhibition. Copyright 2010 Elsevier Inc. All rights reserved.

The Aircraft Simulation Role in Improving Flight Safety Through Control Room Training

NASA Technical Reports Server (NTRS)

Shy, Karla S.; Hageman, Jacob J.; Le, Jeanette H.; Sitz, Joel (Technical Monitor)

2002-01-01

NASA Dryden Flight Research Center uses its six-degrees-of-freedom (6-DOF) fixed-base simulations for mission control room training to improve flight safety and operations. This concept is applied to numerous flight projects such as the F-18 High Alpha Research Vehicle (HARV), the F-15 Intelligent Flight Control System (IFCS), the X-38 Actuator Control Test (XACT), and X-43A (Hyper-X). The Dryden 6-DOF simulations are typically used through various stages of a project, from design to ground tests. The roles of these simulations have expanded to support control room training, reinforcing flight safety by building control room staff proficiency. Real-time telemetry, radar, and video data are generated from flight vehicle simulation models. These data are used to drive the control room displays. Nominal static values are used to complete information where appropriate. Audio communication is also an integral part of training sessions. This simulation capability is used to train control room personnel and flight crew for nominal missions and emergency situations. Such training sessions are also opportunities to refine flight cards and control room display pages, exercise emergency procedures, and practice control room setup for the day of flight. This paper describes this technology as it is used in the X-43A and F-15 IFCS and XACT projects.

Implementation of an Adaptive Controller System from Concept to Flight Test

NASA Technical Reports Server (NTRS)

Larson, Richard R.; Burken, John J.; Butler, Bradley S.

2009-01-01

The National Aeronautics and Space Administration Dryden Flight Research Center (Edwards, California) is conducting ongoing flight research using adaptive controller algorithms. A highly modified McDonnell-Douglas NF-15B airplane called the F-15 Intelligent Flight Control System (IFCS) was used for these algorithms. This airplane has been modified by the addition of canards and by changing the flight control systems to interface a single-string research controller processor for neural network algorithms. Research goals included demonstration of revolutionary control approaches that can efficiently optimize aircraft performance for both normal and failure conditions, and to advance neural-network-based flight control technology for new aerospace systems designs. Before the NF-15B IFCS airplane was certified for flight test, however, certain processes needed to be completed. This paper presents an overview of these processes, including a description of the initial adaptive controller concepts followed by a discussion of modeling formulation and performance testing. Upon design finalization, the next steps are: integration with the system interfaces, verification of the software, validation of the hardware to the requirements, design of failure detection, development of safety limiters to minimize the effect of erroneous neural network commands, and creation of flight test control room displays to maximize human situational awareness.

Application of response surface methodology (RSM) for optimisation of COD, NH3-N and 2,4-DCP removal from recycled paper wastewater in a pilot-scale granular activated carbon sequencing batch biofilm reactor (GAC-SBBR).

PubMed

Muhamad, Mohd Hafizuddin; Sheikh Abdullah, Siti Rozaimah; Mohamad, Abu Bakar; Abdul Rahman, Rakmi; Hasan Kadhum, Abdul Amir

2013-05-30

In this study, the potential of a pilot-scale granular activated carbon sequencing batch biofilm reactor (GAC-SBBR) for removing chemical oxygen demand (COD), ammoniacal nitrogen (NH3-N) and 2,4-dichlorophenol (2,4-DCP) from recycled paper wastewater was assessed. For this purpose, the response surface methodology (RSM) was employed, using a central composite face-centred design (CCFD), to optimise three of the most important operating variables, i.e., hydraulic retention time (HRT), aeration rate (AR) and influent feed concentration (IFC), in the pilot-scale GAC-SBBR process for recycled paper wastewater treatment. Quadratic models were developed for the response variables, i.e., COD, NH3-N and 2,4-DCP removal, based on the high value (>0.9) of the coefficient of determination (R(2)) obtained from the analysis of variance (ANOVA). The optimal conditions were established at 750 mg COD/L IFC, 3.2 m(3)/min AR and 1 day HRT, corresponding to predicted COD, NH3-N and 2,4-DCP removal percentages of 94.8, 100 and 80.9%, respectively. Copyright © 2013 Elsevier Ltd. All rights reserved.

Interfaith education: A new model for today's interfaith families

NASA Astrophysics Data System (ADS)

Gordon, Sheila C.; Arenstein, Benjamin

2017-04-01

With societal changes rapidly transforming cultures that had been largely homogenous, today's multi-cultural - and in particular interfaith - families need new educational strategies to help them understand their cultural roots and identify and clarify what aspects of their heritages they wish to nurture and transmit to their children. This paper focuses on a new model for religious education, namely non-doctrinaire "dual-faith" education, which the principal author has helped to develop in the United States (US) through the Interfaith Community (IFC), a small, independent non-profit organisation created and led by dual-faith Jewish/Christian families. The model is premised on the notion that families can have two different faiths in one household and that - with respect and education - families can be harmonious, religion can be transmitted, and tolerance broadly nurtured. While the model is particular to the US and to families with Jewish and Christian heritages, its premises and structure have significant potential to be adaptable to other religious combinations and other cultures and countries. After reviewing relevant literature and situating the IFC model in the global and US contexts, the paper sets out to clarify the importance of the concept, describe its elements, and discuss its implications for religious education in this time of changing ethos and demography.

Habitus and Social Class: A Case Study on Socialisation into Sports and Exercise

ERIC Educational Resources Information Center

Stuij, Mirjam

2015-01-01

According to Bourdieu, habitus is an important, and class-specific, foundation for behaviour. However, he hardly explained how the habitus is acquired. Based on Bernstein's elaboration on the various contexts in which group-specific behavioural principles are acquired, this article demonstrates how young children of two divergent social classes…

Emerging Scholars: The Class of 2008

ERIC Educational Resources Information Center

Forde, Dana; Lum, Lydia; Nealy, Michelle J.; Pluviose, David; Roach, Ronald; Rogers, Ibram; Rolo, Mark Anthony; Seymour, Add, Jr., Valdata, Patricia; Watson, Jamal

2008-01-01

This year's crop of "Emerging Scholars"--The Class of 2008--includes a math biologist who was only the second woman to receive the Alfred P. Sloan Fellowship in math; a geneticist who recently became one of 20 winners of the National Science Foundation's Presidential Early Career Awards for Scientists and Engineers; and an extensively published…

The Coagulation Method of Starting Lecture-Discussion Courses

ERIC Educational Resources Information Center

Nyberg, David

1976-01-01

Describes a method used in the first class periods of a foundations of education course of 20-35 students to introduce students to each other and develop the interpersonal climate necessary for an effective discussion course. Involves breaking up into groups of five strangers for personal introductions and later class presentations. (JT)

Tried and True: Springing into Linear Models

ERIC Educational Resources Information Center

Darling, Gerald

2012-01-01

In eighth grade, students usually learn about forces in science class and linear relationships in math class, crucial topics that form the foundation for further study in science and engineering. An activity that links these two fundamental concepts involves measuring the distance a spring stretches as a function of how much weight is suspended…

The Value of Childcare: Class, Gender and Caring Labour

ERIC Educational Resources Information Center

Andrew, Yarrow; Newman, Brian

2012-01-01

Despite increasing attention being paid to early childhood services as the foundation for lifelong learning, one issue seems to be consistently ignored--staff wages. The authors argue that this constitutes ongoing exploitation of childcare staff, and that this exploitation is a result of gendered and classed discourses around caring labour. As…

Theoretical foundations of apparent-damping phenomena and nearly irreversible energy exchange in linear conservative systems.

PubMed

Carcaterra, A; Akay, A

2007-04-01

This paper discusses a class of unexpected irreversible phenomena that can develop in linear conservative systems and provides a theoretical foundation that explains the underlying principles. Recent studies have shown that energy can be introduced to a linear system with near irreversibility, or energy within a system can migrate to a subsystem nearly irreversibly, even in the absence of dissipation, provided that the system has a particular natural frequency distribution. The present work introduces a general theory that provides a mathematical foundation and a physical explanation for the near irreversibility phenomena observed and reported in previous publications. Inspired by the properties of probability distribution functions, the general formulation developed here is based on particular properties of harmonic series, which form the common basis of linear dynamic system models. The results demonstrate the existence of a special class of linear nondissipative dynamic systems that exhibit nearly irreversible energy exchange and possess a decaying impulse response. In addition to uncovering a new class of dynamic system properties, the results have far-reaching implications in engineering applications where classical vibration damping or absorption techniques may not be effective. Furthermore, the results also support the notion of nearly irreversible energy transfer in conservative linear systems, which until now has been a concept associated exclusively with nonlinear systems.

Exploring possible selves in a first-year physics foundation class: Engaging students by establishing relevance

NASA Astrophysics Data System (ADS)

Bennett, Dawn; Roberts, Lynne; Creagh, Christine

2016-06-01

Students often complain that they cannot see the relevance of what they are being taught in foundation physics classes. While revising and adjusting the curriculum and teaching are important, this study suggests it might also be useful to help students view their learning in relation to their future career aspirations. This paper reports on a study conducted with first-year students enrolled in a compulsory foundation physics unit with a history of low pass rates. Working within a "possible selves" framework, activities were designed to help students position their learning in relation to possible future lives and careers. Two cohorts of students (N =93 ) engaged in an intensive workshop comprising multiple activities relating to self and career. Self-reflection worksheets were analyzed using content analysis. The results indicate that students experience immediate benefits from these activities through self-reflection on the current self, future possible professional selves, and the role of current studies in narrowing the gap between the two.

Indoor Modelling Benchmark for 3D Geometry Extraction

NASA Astrophysics Data System (ADS)

Thomson, C.; Boehm, J.

2014-06-01

A combination of faster, cheaper and more accurate hardware, more sophisticated software, and greater industry acceptance have all laid the foundations for an increased desire for accurate 3D parametric models of buildings. Pointclouds are the data source of choice currently with static terrestrial laser scanning the predominant tool for large, dense volume measurement. The current importance of pointclouds as the primary source of real world representation is endorsed by CAD software vendor acquisitions of pointcloud engines in 2011. Both the capture and modelling of indoor environments require great effort in time by the operator (and therefore cost). Automation is seen as a way to aid this by reducing the workload of the user and some commercial packages have appeared that provide automation to some degree. In the data capture phase, advances in indoor mobile mapping systems are speeding up the process, albeit currently with a reduction in accuracy. As a result this paper presents freely accessible pointcloud datasets of two typical areas of a building each captured with two different capture methods and each with an accurate wholly manually created model. These datasets are provided as a benchmark for the research community to gauge the performance and improvements of various techniques for indoor geometry extraction. With this in mind, non-proprietary, interoperable formats are provided such as E57 for the scans and IFC for the reference model. The datasets can be found at: http://indoor-bench.github.io/indoor-bench.

26 CFR 143.6 - Election to shorten the period during which certain excess business holdings of private...

Code of Federal Regulations, 2012 CFR

2012-04-01

... foundation with respect to which the election is being made and to the management of such business enterprise... enterprise exceed 75 percent of the voting stock or more than a 75 percent interest in the value of all outstanding shares of all classes of stock in such enterprise, and the foundation's holdings on such date do...

26 CFR 143.6 - Election to shorten the period during which certain excess business holdings of private...

Code of Federal Regulations, 2013 CFR

2013-04-01

... foundation with respect to which the election is being made and to the management of such business enterprise... enterprise exceed 75 percent of the voting stock or more than a 75 percent interest in the value of all outstanding shares of all classes of stock in such enterprise, and the foundation's holdings on such date do...

26 CFR 143.6 - Election to shorten the period during which certain excess business holdings of private...

Code of Federal Regulations, 2011 CFR

2011-04-01

... foundation with respect to which the election is being made and to the management of such business enterprise... enterprise exceed 75 percent of the voting stock or more than a 75 percent interest in the value of all outstanding shares of all classes of stock in such enterprise, and the foundation's holdings on such date do...

26 CFR 143.6 - Election to shorten the period during which certain excess business holdings of private...

Code of Federal Regulations, 2014 CFR

2014-04-01

... foundation with respect to which the election is being made and to the management of such business enterprise... enterprise exceed 75 percent of the voting stock or more than a 75 percent interest in the value of all outstanding shares of all classes of stock in such enterprise, and the foundation's holdings on such date do...

Diminishing Manufacturing Sources and Material Shortages (DMSMS) Guidebook

DTIC Science & Technology

2006-11-01

www.dau.mil/registrar/enroll.aspx DoD Acquisition, Technology, and Logistics (AT&L) Integrated Framework Chart (IFC) lifecycle activities and...ROI) and Break Even Point ( BEP ). Two analysts could look at the same data and generate different outcomes if they use different assumptions or...principal output of the BCA is the Break Even Point ( BEP ), which shows the payback period of an alternative. It is found from a plot of the

Method for simulating discontinuous physical systems

DOEpatents

Baty, Roy S.; Vaughn, Mark R.

2001-01-01

The mathematical foundations of conventional numerical simulation of physical systems provide no consistent description of the behavior of such systems when subjected to discontinuous physical influences. As a result, the numerical simulation of such problems requires ad hoc encoding of specific experimental results in order to address the behavior of such discontinuous physical systems. In the present invention, these foundations are replaced by a new combination of generalized function theory and nonstandard analysis. The result is a class of new approaches to the numerical simulation of physical systems which allows the accurate and well-behaved simulation of discontinuous and other difficult physical systems, as well as simpler physical systems. Applications of this new class of numerical simulation techniques to process control, robotics, and apparatus design are outlined.

Preparing TESOL Students for the ESOL Classroom: A Cross-Cultural Project in Intercultural Communication

ERIC Educational Resources Information Center

Medina-López-Portillo, Adriana

2014-01-01

Intercultural communication classes for TESOL students give them a solid foundation for their work with their own ESOL students. This article presents the cross-cultural project that TESOL students have to complete in a required intercultural communication class at the University of Maryland, Baltimore County and the case study that was used to…

Development of Children's Creativity and Manual Skills within Digital Game-Based Learning Environment

ERIC Educational Resources Information Center

Hsiao, H-S.; Chang, C-S.; Lin, C-Y.; Hu, P-M.

2014-01-01

In this study, we developed a digital game-based learning (DGBL) system, called the ToES, to foster students' creativity. Fifty-one fifth-grade students from two classes in a public school in Taipei, Taiwan, were recruited and consented to participate. Both classes consisted of students with mixed abilities studying a foundation unit entitled…

The Dynamics of Learning Science in Everyday Contexts: A Case Study of Everyday Science Class in Korea

ERIC Educational Resources Information Center

Kim, Mijung; Yoon, Heesook; Ji, Young Rae; Song, Jinwoong

2012-01-01

With recognition of the importance of scientific literacy for the nation and yet the increasing students' disinterest in science through school science curriculum, the Korea Science Foundation launched an innovative program called "Everyday Science Class (ESC)" in partnership with universities and local government offices in 2003. In…

We're in Math Class Playing Games, Not Playing Games in Math Class

ERIC Educational Resources Information Center

McFeetors, P. Janelle; Palfy, Kylie

2017-01-01

Early experiences of reasoning while playing games of strategy are foundational for future proofs that students will be expected to build using conventionally structured arguments. But how did game playing in school occur? How can educators be sure that mathematical reasoning is going on? The authors investigated these questions to understand how…

Future of Hydroinformatics: Towards Open, Integrated and Interactive Online Platforms

NASA Astrophysics Data System (ADS)

Demir, I.; Krajewski, W. F.

2012-12-01

Hydroinformatics is a domain of science and technology dealing with the management of information in the field of hydrology (IWA, 2011). There is the need for innovative solutions to the challenges towards open information, integration, and communication in the Internet. This presentation provides an overview of the trends and challenges in the future of hydroinformatics, and demonstrates an information system, Iowa Flood Information System (IFIS), developed within the light of these challenges. The IFIS is a web-based platform developed by the Iowa Flood Center (IFC) to provide access to flood inundation maps, real-time flood conditions, flood forecasts both short-term and seasonal, flood-related data, information and interactive visualizations for communities in Iowa. The key element of the system's architecture is the notion of community. Locations of the communities, those near streams and rivers, define basin boundaries. The IFIS provides community-centric watershed and river characteristics, weather (rainfall) conditions, and streamflow data and visualization tools. Interactive interfaces allow access to inundation maps for different stage and return period values, and flooding scenarios with contributions from multiple rivers. Real-time and historical data of water levels, gauge heights, and rainfall conditions are available in the IFIS by streaming data from automated IFC bridge sensors, USGS stream gauges, NEXRAD radars, and NWS forecasts. 2D and 3D interactive visualizations in the IFIS make the data more understandable to general public. Users are able to filter data sources for their communities and selected rivers. The data and information on IFIS is also accessible through web services and mobile applications. The IFIS is optimized for various browsers and screen sizes to provide access through multiple platforms including tablets and mobile devices. The IFIS includes a rainfall-runoff forecast model to provide a five-day flood risk estimate for more than 1000 communities in Iowa. Multiple view modes in the IFIS accommodate different user types from general public to researchers and decision makers by providing different level of tools and details. River view mode allows users to visualize data from multiple IFC bridge sensors and USGS stream gauges to follow flooding condition along a river. The IFIS will help communities make better-informed decisions on the occurrence of floods, and will alert communities in advance to help minimize damage of floods.

Morality and Intimate Partner Violence: Do Men in Court-Mandated Psychological Treatment Hold a Sacred Moral Vision of the World and Themselves?

PubMed

Vecina, María L; Chacón, José C

2016-01-01

This article examines the characterization of men in a court-mandated treatment for violence against their partners as holding a sacred vision of the 5 moral foundations and of their own morality. This characterization is compatible with the assumption that a sacred moral world is easily threatened by reality and that may be associated to violent defensive actions. The results from latent class analyses reveal (a) a 4-class distribution depending exclusively on the intensity with which all participants (violent and nonviolent) tend to sacralize the actions proposed in the Moral Foundations Sacredness Scale and (b) a greater prevalence of the violent participants among the classes that are more prone to sacralize. They also show that they hold an inflated moral vision of themselves: They think they are much more moral than intelligent than others who have never been charged with criminal behavior (Muhammad Ali effect).

Verification and Validation of Neural Networks for Aerospace Systems

NASA Technical Reports Server (NTRS)

Mackall, Dale; Nelson, Stacy; Schumman, Johann; Clancy, Daniel (Technical Monitor)

2002-01-01

The Dryden Flight Research Center V&V working group and NASA Ames Research Center Automated Software Engineering (ASE) group collaborated to prepare this report. The purpose is to describe V&V processes and methods for certification of neural networks for aerospace applications, particularly adaptive flight control systems like Intelligent Flight Control Systems (IFCS) that use neural networks. This report is divided into the following two sections: 1) Overview of Adaptive Systems; and 2) V&V Processes/Methods.

Verification and Validation of Neural Networks for Aerospace Systems

NASA Technical Reports Server (NTRS)

Mackall, Dale; Nelson, Stacy; Schumann, Johann

2002-01-01

The Dryden Flight Research Center V&V working group and NASA Ames Research Center Automated Software Engineering (ASE) group collaborated to prepare this report. The purpose is to describe V&V processes and methods for certification of neural networks for aerospace applications, particularly adaptive flight control systems like Intelligent Flight Control Systems (IFCS) that use neural networks. This report is divided into the following two sections: Overview of Adaptive Systems and V&V Processes/Methods.

Measurement Uncertainty Within the Uniform Engine Test Programme

DTIC Science & Technology

1989-05-01

Design to Cost and l.ifc (.cle Cost to Aircraft Engines AGARD LS 107 (May 1980) Microcomputer Applications in Power and Propulsion Systems AGARD LS...Flows in Propulsion Systems AGARD LS 140 (June 1985) Engine Airframe Integration for Rotorcraft AGARD LS 148 (June 1986) Design Methods Used in Solid...modest nero-thermodynamic design was of no consequence. Two engines were loaned to the proeram by the U.S. Air Force. Due to higher priority test workload

Repetitive behaviors in autism are linked to imbalance of corticostriatal connectivity: a functional connectivity MRI study.

PubMed

Abbott, Angela E; Linke, Annika C; Nair, Aarti; Jahedi, Afrooz; Alba, Laura A; Keown, Christopher L; Fishman, Inna; Müller, Ralph-Axel

2018-01-01

The neural underpinnings of repetitive behaviors (RBs) in autism spectrum disorders (ASDs), ranging from cognitive to motor characteristics, remain unknown. We assessed RB symptomatology in 50 ASD and 52 typically developing (TD) children and adolescents (ages 8-17 years), examining intrinsic functional connectivity (iFC) of corticostriatal circuitry, which is important for reward-based learning and integration of emotional, cognitive and motor processing, and considered impaired in ASDs. Connectivity analyses were performed for three functionally distinct striatal seeds (limbic, frontoparietal and motor). Functional connectivity with cortical regions of interest was assessed for corticostriatal circuit connectivity indices and ratios, testing the balance of connectivity between circuits. Results showed corticostriatal overconnectivity of limbic and frontoparietal seeds, but underconnectivity of motor seeds. Correlations with RBs were found for connectivity between the striatal motor seeds and cortical motor clusters from the whole-brain analysis, and for frontoparietal/limbic and motor/limbic connectivity ratios. Division of ASD participants into high (n = 17) and low RB subgroups (n = 19) showed reduced frontoparietal/limbic and motor/limbic circuit ratios for high RB compared to low RB and TD groups in the right hemisphere. Results suggest an association between RBs and an imbalance of corticostriatal iFC in ASD, being increased for limbic, but reduced for frontoparietal and motor circuits. © The Author (2017). Published by Oxford University Press.

Repetitive behaviors in autism are linked to imbalance of corticostriatal connectivity: a functional connectivity MRI study

PubMed Central

Abbott, Angela E; Linke, Annika C; Nair, Aarti; Jahedi, Afrooz; Alba, Laura A; Keown, Christopher L; Fishman, Inna

2018-01-01

Abstract The neural underpinnings of repetitive behaviors (RBs) in autism spectrum disorders (ASDs), ranging from cognitive to motor characteristics, remain unknown. We assessed RB symptomatology in 50 ASD and 52 typically developing (TD) children and adolescents (ages 8–17 years), examining intrinsic functional connectivity (iFC) of corticostriatal circuitry, which is important for reward-based learning and integration of emotional, cognitive and motor processing, and considered impaired in ASDs. Connectivity analyses were performed for three functionally distinct striatal seeds (limbic, frontoparietal and motor). Functional connectivity with cortical regions of interest was assessed for corticostriatal circuit connectivity indices and ratios, testing the balance of connectivity between circuits. Results showed corticostriatal overconnectivity of limbic and frontoparietal seeds, but underconnectivity of motor seeds. Correlations with RBs were found for connectivity between the striatal motor seeds and cortical motor clusters from the whole-brain analysis, and for frontoparietal/limbic and motor/limbic connectivity ratios. Division of ASD participants into high (n = 17) and low RB subgroups (n = 19) showed reduced frontoparietal/limbic and motor/limbic circuit ratios for high RB compared to low RB and TD groups in the right hemisphere. Results suggest an association between RBs and an imbalance of corticostriatal iFC in ASD, being increased for limbic, but reduced for frontoparietal and motor circuits. PMID:29177509

Recent advances in PC-Linux systems for electronic structure computations by optimized compilers and numerical libraries.

PubMed

Yu, Jen-Shiang K; Yu, Chin-Hui

2002-01-01

One of the most frequently used packages for electronic structure research, GAUSSIAN 98, is compiled on Linux systems with various hardware configurations, including AMD Athlon (with the "Thunderbird" core), AthlonMP, and AthlonXP (with the "Palomino" core) systems as well as the Intel Pentium 4 (with the "Willamette" core) machines. The default PGI FORTRAN compiler (pgf77) and the Intel FORTRAN compiler (ifc) are respectively employed with different architectural optimization options to compile GAUSSIAN 98 and test the performance improvement. In addition to the BLAS library included in revision A.11 of this package, the Automatically Tuned Linear Algebra Software (ATLAS) library is linked against the binary executables to improve the performance. Various Hartree-Fock, density-functional theories, and the MP2 calculations are done for benchmarking purposes. It is found that the combination of ifc with ATLAS library gives the best performance for GAUSSIAN 98 on all of these PC-Linux computers, including AMD and Intel CPUs. Even on AMD systems, the Intel FORTRAN compiler invariably produces binaries with better performance than pgf77. The enhancement provided by the ATLAS library is more significant for post-Hartree-Fock calculations. The performance on one single CPU is potentially as good as that on an Alpha 21264A workstation or an SGI supercomputer. The floating-point marks by SpecFP2000 have similar trends to the results of GAUSSIAN 98 package.

Liver disease - resources

MedlinePlus

Resources - liver disease ... The following organizations are good resources for information on liver disease : American Liver Foundation -- www.liverfoundation.org Children's Liver Association for Support Services (C.L.A.S.S.) -- www. ...

Laying a Foundation for Lifelong Learning: Case Studies of E-Assessment in Large 1st-Year Classes

ERIC Educational Resources Information Center

Nicol, David

2007-01-01

Concerns about noncompletion and the quality of the 1st-year student experience have been linked to recent changes in higher education such as modularisation, increased class sizes, greater diversity in the student intake and reduced resources. Improving formative assessment and feedback processes is seen as one way of addressing academic failure,…

Two Teacher Educators Go to the Source: Teaching an Interdisciplinary Class in an Urban Charter High School

ERIC Educational Resources Information Center

DiCamillo, Lorrei; Bailey, Nancy M.

2016-01-01

The authors of this article are two teacher educators who worked collaboratively to co-teach an interdisciplinary English and US history class to eleventh-grade students in an urban high school. They wanted to ensure the methods they were teaching preservice teachers were current and effective. The article discusses the foundational beliefs that…

Building a World-Class Front-Line Workforce: The Need for Occupational Skill Standards in State Workforce Preparation Programs. EQW Working Papers.

ERIC Educational Resources Information Center

Sheets, Robert G.

Establishment of a national-state system of world-class occupational skill standards is a first step in restructuring adult vocational-technical education and job training programs. Occupational skills standards provide the necessary foundation for addressing three major state policy issues: the state's proper role in private work-based training,…

Strategic Reinvention: The Rodel Foundation of Delaware's Journey to Catalyzing a System of World-Class Schools. Principles for Effective Education Grantmaking. Case Study No. 10

ERIC Educational Resources Information Center

Jenkins, Lynn; Wisdom, Michelle

2014-01-01

As the summer of 2014 began, Paul Herdman, President and CEO of the Rodel Charitable Foundation of Delaware, paused to reflect on what Delaware had accomplished over the past decade in the public education realm. Academic standards had been raised across the K-12 system, and a new assessment system aligned to those standards was being implemented.…

Se substitution and micro-nano-scale porosity enhancing thermoelectric Cu2Te

NASA Astrophysics Data System (ADS)

Shi, Xiaoman; Wang, Guoyu; Wang, Ruifeng; Zhou, Xiaoyuan; Xu, Jingtao; Tang, Jun; Ang, Ran

2018-04-01

Not Available Project supported by the National Natural Science Foundation of China (Grant Nos. 51771126 and 11774247), the Youth Foundation of Science and Technology Department of Sichuan Province, China (Grant No. 2016JQ0051), Sichuan University Outstanding Young Scholars Research Funding (Grant No. 2015SCU04A20), the World First-Class University Construction Funding, and the Fundamental and Frontier Research Project in Chongqing (Grant No. CSTC2015JCYJBX0026).

Performance Monitoring and Assessment of Neuro-Adaptive Controllers for Aerospace Applications Using a Bayesian Approach

NASA Technical Reports Server (NTRS)

Gupta, Pramod; Guenther, Kurt; Hodgkinson, John; Jacklin, Stephen; Richard, Michael; Schumann, Johann; Soares, Fola

2005-01-01

Modern exploration missions require modern control systems-control systems that can handle catastrophic changes in the system's behavior, compensate for slow deterioration in sustained operations, and support fast system ID. Adaptive controllers, based upon Neural Networks have these capabilities, but they can only be used safely if proper verification & validation (V&V) can be done. In this paper we present our V & V approach and simulation result within NASA's Intelligent Flight Control Systems (IFCS).

Directed Energy Beam Jitter Mitigation Using the Line-of-Sight Reference Frame

DTIC Science & Technology

2011-05-10

tg,’Connected’); C4 = ’Yes’ TF1 =strcmp(C1, C2);TF2=strcmp(C3, C4); if ~ TF1 ; unload(tg); load(tg,’FFD_9’); tg=xpctarget.xpc; end if...C1 = (get(tg,’Application’));C2=’FFD_9’C3 = get(tg,’Connected’); C4 = ’Yes’ TF1 =strcmp(C1, C2);TF2=strcmp(C3, C4); if ~ TF1 ; unload(tg

BOREAS TE-5 Surface Meteorological and Radiation Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Ehleriinger, Jim; Brooks, J. Renee; Flanagan, Larry

2000-01-01

The BOREAS TE-5 team collected measurements in the NSA and SSA on gas exchange, gas composition, and tree growth. Measurements of meteorological data, including air and soil temperature, RH, and PPFD, were 30-minute intervals during the 1994 IFCs at various sites in the BOREAS NSA and SSA. The data are provided in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

In vitro microleakage of luting cements and crown foundation material.

PubMed

Lindquist, T J; Connolly, J

2001-03-01

Microleakage is a concern for the long-term prognosis of a cemented crown and foundation. The aims of this investigation were, first, to evaluate microleakage of zinc phosphate cement and resin-reinforced glass ionomer cement under ideal (dry) versus contaminated (wet) conditions, and second, to compare 3 foundations under both ideal and contaminated conditions. One hundred forty extracted molar teeth were cleaned and mounted. Tooth preparations for complete veneer cast crowns were completed with a chamfer finish line. A mesial surface class II cavity preparation 4 mm wide buccolingually and 2 mm deep was made in each tooth. Seven restorative groups were formed: amalgam/cavity varnish, amalgam/dentinal bonding agent, and composite/dentinal bonding agent, each with dry and contaminated groups, and a seventh group of class II cavity preparations without foundations. Finish lines for crown margins were refined 1.5 mm gingival to the restoration. Artificial crowns were cast in type III gold. Treatment groups were divided into 4 cement groups: dry and contaminated zinc phosphate cement and dry and contaminated resin-reinforced glass ionomer cement. The specimens were thermocycled and immersed in erythrosine B solution for 24 hours. Subsequently, they were rinsed, and their coronal portions were embedded in clear resin. Teeth were sectioned mesiodistally, and standard photomicrographs were made. The microleakage of each restoration and crown was measured. The least foundation microleakage was recorded for amalgam/dentinal bonding agents (ideal group) and composite/dentinal bonding agents (ideal group). The most microleakage was observed within the group without a foundation. In cement groups, the control and experiment sides were evaluated separately but displayed the same order of finding. The least leakage was recorded with resin-reinforced glass ionomer cement (ideal group); the most microleakage was noted with zinc phosphate cement (ideal group). An interaction was demonstrated on the experimental side between cements and the foundations (P=.0001). Within the experimental conditions of this study, less microleakage was recorded with resin-reinforced glass ionomer cement (ideal or contaminated) than with zinc phosphate cement (ideal or contaminated). There also was less microleakage evident with a foundation of silver amalgam or composite when a dentinal bonding agent was used under ideal conditions.

77 FR 13479 - Read Across America Day, 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

... critical thinking skills that provide the foundation for a world-class education. By working together to give our sons and daughters the tools for achievement, we lay the groundwork for growth and prosperity...

Wetlands Management and risk for West Nile Virus Circulation in Camargue, Southern France

NASA Astrophysics Data System (ADS)

Leblond, Agnes; Pradier, Sophie; Paul, Mathilde; Lecollinet, Sylvie; Sandoz, Alain

2016-04-01

West Nile Virus (WNV) is a flavivirus transmitted between mosquitoes (mainly the genus Culex) and wild birds. Horses and humans are incidental hosts and can develop severe neurological disorders. During last decades, the number of WNV cases reported in Europe has increased dramatically. Large outbreaks of increased clinical severity have been reported in parts of Russia, Southern and Eastern Europe. In the Camargue area, WNV outbreaks have been reported in 2000, 2004 and more recently in 2015. We hypothesize that the management of Camargue wetlands could play a key role in the emergence of outbreaks in this area during recent years. WNV transmission requires competent vectors, receptive hosts, and environmental parameters which allow contact between the vectors and the different hosts. The Rhône Delta is known for its landscape of wetlands and its wealth of different bird species. It is also a region where mosquito populations are very abundant. Recent observations have shown that environmental changes, mainly resulting from anthropogenic practices, have had an impact on inter-annual variations in the wetlands and consequently on the abundance of mosquitoes. Water is provided either by rainfall or by a very tight canal network diverted from the river Rhone. Water management is under the control of individual field owners and dependent on its various uses (grazing, rice culture, hunting reserves). This specific management of water resources could play a role in the circulation of WNV in the area. Non-vaccinated horses (n = 1159 from 134 stables) were sampled in 2007 and 2008 in the Camargue area and a serological test was performed to identify a possible contact with the WNV. Environmental variables related to water resources and management were collected through fifteen Landsat images. Areas with open water and flooded vegetation and their variations within a year and between years (2007-08) were quantified for buffers of 2 km radius around the stables. Mean percentages of areas of open water and flooded vegetation, as well as variations in these percentages between 3 periods were calculated. The 3 periods were defined according to our knowledge on WNV circulation and epidemiology in the area, i.e. November to February (winter), not at risk period for WNV circulation; March to July (spring), mosquito-birds WNV cycle period; and August to October (autumn), WNV outbreak period. Results of logistic regression demonstrated that horses' serological status was significantly associated with the variations of open water areas between the not at risk and the mosquito-bird cycle periods, as well as between the mosquito-bird cycle and the outbreak periods. WNV spillover was found more intense in areas where water level decreased strongly from winter to spring and from spring to autumn. These results could help decision-makers to target risk-based surveillance on high-risk areas. Acknowledgments: We thank the "Institut Français du Cheval et de l'Equitation" (IFCE: http://www.ifce.fr/) and the foundation MAVA for their financial support.

Translations on Eastern Europe, Scientific Affairs, Number 537

DTIC Science & Technology

1977-03-07

Security Class (This Report) UNCLASSIFIED 20. Security Class (This Page UNCLASSIFIED 21. No. of Pages 22. Price KORM N riS-:i5 1R17.V...the new five-year plan too, the rapid.and secure development of industry is tied directly to the expansion of the mineral extracting and processing... cybernetic aspects supplied those foundations for generalizations and possibilities of abstraction, which the individual sciences needed. Not until

Working memory load modulation of parieto-frontal connections: evidence from dynamic causal modeling

PubMed Central

Ma, Liangsuo; Steinberg, Joel L.; Hasan, Khader M.; Narayana, Ponnada A.; Kramer, Larry A.; Moeller, F. Gerard

2011-01-01

Previous neuroimaging studies have shown that working memory load has marked effects on regional neural activation. However, the mechanism through which working memory load modulates brain connectivity is still unclear. In this study, this issue was addressed using dynamic causal modeling (DCM) based on functional magnetic resonance imaging (fMRI) data. Eighteen normal healthy subjects were scanned while they performed a working memory task with variable memory load, as parameterized by two levels of memory delay and three levels of digit load (number of digits presented in each visual stimulus). Eight regions of interest, i.e., bilateral middle frontal gyrus (MFG), anterior cingulate cortex (ACC), inferior frontal cortex (IFC), and posterior parietal cortex (PPC), were chosen for DCM analyses. Analysis of the behavioral data during the fMRI scan revealed that accuracy decreased as digit load increased. Bayesian inference on model structure indicated that a bilinear DCM in which memory delay was the driving input to bilateral PPC and in which digit load modulated several parieto-frontal connections was the optimal model. Analysis of model parameters showed that higher digit load enhanced connection from L PPC to L IFC, and lower digit load inhibited connection from R PPC to L ACC. These findings suggest that working memory load modulates brain connectivity in a parieto-frontal network, and may reflect altered neuronal processes, e.g., information processing or error monitoring, with the change in working memory load. PMID:21692148

Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample.

PubMed

Pan, Pedro Mario; Sato, João R; Salum, Giovanni A; Rohde, Luis A; Gadelha, Ary; Zugman, Andre; Mari, Jair; Jackowski, Andrea; Picon, Felipe; Miguel, Eurípedes C; Pine, Daniel S; Leibenluft, Ellen; Bressan, Rodrigo A; Stringaris, Argyris

2017-11-01

Previous studies have implicated aberrant reward processing in the pathogenesis of adolescent depression. However, no study has used functional connectivity within a distributed reward network, assessed using resting-state functional MRI (fMRI), to predict the onset of depression in adolescents. This study used reward network-based functional connectivity at baseline to predict depressive disorder at follow-up in a community sample of adolescents. A total of 637 children 6-12 years old underwent resting-state fMRI. Discovery and replication analyses tested intrinsic functional connectivity (iFC) among nodes of a putative reward network. Logistic regression tested whether striatal node strength, a measure of reward-related iFC, predicted onset of a depressive disorder at 3-year follow-up. Further analyses investigated the specificity of this prediction. Increased left ventral striatum node strength predicted increased risk for future depressive disorder (odds ratio=1.54, 95% CI=1.09-2.18), even after excluding participants who had depressive disorders at baseline (odds ratio=1.52, 95% CI=1.05-2.20). Among 11 reward-network nodes, only the left ventral striatum significantly predicted depression. Striatal node strength did not predict other common adolescent psychopathology, such as anxiety, attention deficit hyperactivity disorder, and substance use. Aberrant ventral striatum functional connectivity specifically predicts future risk for depressive disorder. This finding further emphasizes the need to understand how brain reward networks contribute to youth depression.

Voluntary inhibition of pain avoidance behavior: an fMRI study.

PubMed

Lynn, Margaret T; Demanet, Jelle; Krebs, Ruth M; Van Dessel, Pieter; Brass, Marcel

2016-04-01

Behavioral inhibition has classically been considered to rely upon a neural network centered at the right inferior frontal cortex [rIFC; Aron et al. (8:170-177, 2004; 18:177-185, 2014)]. However, the vast majority of inhibition studies have entailed exogenous stop signals instructing participants to withhold responding. More recent work has begun to examine the neural underpinnings of endogenous inhibition, revealing a distinct cortical basis in the dorsal fronto-median cortex [dFMC; Brass and Haggard (27:9141-9145, 2007); Kühn et al. (30:2834-3843, 2009)]. Yet, contrary to everyday experiences of voluntary behavioral suppression, the paradigms employed to investigate action inhibition have thus far been somewhat artificial, and involve little persuasive motivation to act. Accordingly, the present fMRI study seeks to compare and contrast intentional with instructed inhibition in a novel pain paradigm that recruits 'hot' incentive response systems. Participants received increasing thermal stimulation to their inner wrists, and were required to occasionally withhold their natural impulse to withdraw from the compelling pain sensation at peak temperature, in both instructed and free-choice conditions. Consistent with previous research, we observed inhibition-related activity in the dFMC and the rIFC. However, these regions displayed equivalent activation levels for both inhibition types. These data extend previous research by demonstrating that under ecologically valid conditions with a strong motivation to act, both stopping networks operate in concert to enable suppression of unwanted behavior.

Ifcwall Reconstruction from Unstructured Point Clouds

NASA Astrophysics Data System (ADS)

Bassier, M.; Klein, R.; Van Genechten, B.; Vergauwen, M.

2018-05-01

The automated reconstruction of Building Information Modeling (BIM) objects from point cloud data is still ongoing research. A key aspect is the creation of accurate wall geometry as it forms the basis for further reconstruction of objects in a BIM. After segmenting and classifying the initial point cloud, the labelled segments are processed and the wall topology is reconstructed. However, the preocedure is challenging due to noise, occlusions and the complexity of the input data.In this work, a method is presented to automatically reconstruct consistent wall geometry from point clouds. More specifically, the use of room information is proposed to aid the wall topology creation. First, a set of partial walls is constructed based on classified planar primitives. Next, the rooms are identified using the retrieved wall information along with the floors and ceilings. The wall topology is computed by the intersection of the partial walls conditioned on the room information. The final wall geometry is defined by creating IfcWallStandardCase objects conform the IFC4 standard. The result is a set of walls according to the as-built conditions of a building. The experiments prove that the used method is a reliable framework for wall reconstruction from unstructured point cloud data. Also, the implementation of room information reduces the rate of false positives for the wall topology. Given the walls, ceilings and floors, 94% of the rooms is correctly identified. A key advantage of the proposed method is that it deals with complex rooms and is not bound to single storeys.

A Hydrologic Routing Model Based on Geomorphological Characteristics of the River Network

NASA Astrophysics Data System (ADS)

Krajewski, W. F.; Quintero, F.; Ghimire, G.; Rojas, M.

2017-12-01

The Iowa Flood Center (IFC) provides streamflow forecasts for about 2000 locations in Iowa using a real-time distributed hydrologic model, forced with radar and raingage rainfall information. The model structure is based on ordinary differential equations that represent the flow of water from the hillslopes to the channels of the river network. The formulation of the routing of water across the rivers constitutes a fundamental aspect of the model, because this component is mostly responsible for providing estimates of the time-to-peak and peak magnitude. The routing model structure of the system is based on the scaling properties of river velocity with the discharge and drainage area of the channel, which can be written in terms of a power-law function. This study examines how this scaling relation is connected to the Horton-Strahler order of the channel network. This evaluation represents a step forward towards formulating model structures that are based on characteristics that are invariant across spatial scales. We proposed a routing model for every different Horton orders of the network, by adjusting a power-law function to available observations of velocity and discharge provided by USGS. The models were implemented into the Hillslope-Link Model (HLM) of the IFC for offline evaluation. Model simulations were compared to discharge observations to assess their performance, and compared to simulations obtained with other hydrologic routing schemes, to determine if the new formulation improves performance of the model.

Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis.

PubMed

Gorka, Adam X; Torrisi, Salvatore; Shackman, Alexander J; Grillon, Christian; Ernst, Monique

2018-03-01

The central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST), two nuclei within the central extended amygdala, function as critical relays within the distributed neural networks that coordinate sensory, emotional, and cognitive responses to threat. These structures have overlapping anatomical projections to downstream targets that initiate defensive responses. Despite these commonalities, researchers have also proposed a functional dissociation between the CeA and BNST, with the CeA promoting responses to discrete stimuli and the BNST promoting responses to diffuse threat. Intrinsic functional connectivity (iFC) provides a means to investigate the functional architecture of the brain, unbiased by task demands. Using ultra-high field neuroimaging (7-Tesla fMRI), which provides increased spatial resolution, this study compared the iFC networks of the CeA and BNST in 27 healthy individuals. Both structures were coupled with areas of the medial prefrontal cortex, hippocampus, thalamus, and periaqueductal gray matter. Compared to the BNST, the bilateral CeA was more strongly coupled with the insula and regions that support sensory processing, including thalamus and fusiform gyrus. In contrast, the bilateral BNST was more strongly coupled with regions involved in cognitive and motivational processes, including the dorsal paracingulate gyrus, posterior cingulate cortex, and striatum. Collectively, these findings suggest that responses to sensory stimulation are preferentially coordinated by the CeA and cognitive and motivational responses are preferentially coordinated by the BNST. Published by Elsevier Inc.

Ab initio computational study on the lattice thermal conductivity of Zintl clathrates [Si19P4] Cl4 and Na4[Al4Si19

NASA Astrophysics Data System (ADS)

Härkönen, Ville J.; Karttunen, Antti J.

2016-08-01

The lattice thermal conductivity of silicon clathrate framework Si23 and two Zintl clathrates, [Si19P4] Cl4 and Na4[Al4Si19] , is investigated by using an iterative solution of the linearized Boltzmann transport equation in conjunction with ab initio lattice dynamical techniques. At 300 K, the lattice thermal conductivities for Si23, [Si19P4] Cl4 , and Na4[Al4Si19] were found to be 43 W/(m K), 25 W/(m K), and 2 W/(m K), respectively. In the case of Na4[Al4Si19] , the order-of-magnitude reduction in the lattice thermal conductivity was found to be mostly due to relaxation times and group velocities differing from Si23 and [Si19P4] Cl4 . The difference in the relaxation times and group velocities arises primarily due to the phonon spectrum at low frequencies, resulting eventually from the differences in the second-order interatomic force constants (IFCs). The obtained third-order IFCs were rather similar for all materials considered here. The present findings are similar to those obtained earlier for some skutterudites. The predicted lattice thermal conductivity of Na4[Al4Si19] is in line with the experimentally measured thermal conductivity of recently synthesized type-I Zintl clathrate Na8[Al8Si38] (polycrystalline samples).

A convergent functional architecture of the insula emerges across imaging modalities.

PubMed

Kelly, Clare; Toro, Roberto; Di Martino, Adriana; Cox, Christine L; Bellec, Pierre; Castellanos, F Xavier; Milham, Michael P

2012-07-16

Empirical evidence increasingly supports the hypothesis that patterns of intrinsic functional connectivity (iFC) are sculpted by a history of evoked coactivation within distinct neuronal networks. This, together with evidence of strong correspondence among the networks defined by iFC and those delineated using a variety of other neuroimaging techniques, suggests a fundamental brain architecture detectable across multiple functional and structural imaging modalities. Here, we leverage this insight to examine the functional organization of the human insula. We parcellated the insula on the basis of three distinct neuroimaging modalities - task-evoked coactivation, intrinsic (i.e., task-independent) functional connectivity, and gray matter structural covariance. Clustering of these three different covariance-based measures revealed a convergent elemental organization of the insula that likely reflects a fundamental brain architecture governing both brain structure and function at multiple spatial scales. While not constrained to be hierarchical, our parcellation revealed a pseudo-hierarchical, multiscale organization that was consistent with previous clustering and meta-analytic studies of the insula. Finally, meta-analytic examination of the cognitive and behavioral domains associated with each of the insular clusters obtained elucidated the broad functional dissociations likely underlying the topography observed. To facilitate future investigations of insula function across healthy and pathological states, the insular parcels have been made freely available for download via http://fcon_1000.projects.nitrc.org, along with the analytic scripts used to perform the parcellations. Copyright © 2012 Elsevier Inc. All rights reserved.

Band engineering and precipitation enhance thermoelectric performance of SnTe with Zn-doping

NASA Astrophysics Data System (ADS)

Chen, Zhiyu; Wang, Ruifeng; Wang, Guoyu; Zhou, Xiaoyuan; Wang, Zhengshang; Yin, Cong; Hu, Qing; Zhou, Binqiang; Tang, Jun; Ang, Ran

2018-04-01

Not Available Project supported by the National Natural Science Foundation of China (Grant No. 51771126), the Youth Foundation of Science & Technology Department of Sichuan Province, China (Grant No. 2016JQ0051), the Sichuan University Talent Introduction Research Funding (Grand No. YJ201537), the Sichuan University Outstanding Young Scholars Research Funding (Grant No. 2015SCU04A20), the World First-Class University Construction Funding, and the Fundamental and Frontier Research in Chongqing (Grant No. CSTC2015JCYJBX0026).

78 FR 34608 - Proposed Establishment of Class D Airspace; Bryant AAF, Anchorage, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... Association (AOPA), Alaska Airmen's Association (AAA), and the Alaskan Aviation Safety Foundation (AASF). One... D airspace. The AAA requested additional time to review the proposal and that the entire composition...

Complex Networks/Foundations of Information Systems

DTIC Science & Technology

2013-03-06

the benefit of feedback or dynamic correlations in coding and protocol. Using Renyi correlation analysis and entropy to model this wider class of...dynamic heterogeneous conditions. Lizhong Zheng, MIT Renyi Channel Correlation Analysis (connected to geometric curvature) Network Channel

On a class of integrals of Legendre polynomials with complicated arguments--with applications in electrostatics and biomolecular modeling.

PubMed

Yu, Yi-Kuo

2003-08-15

The exact analytical result for a class of integrals involving (associated) Legendre polynomials of complicated argument is presented. The method employed can in principle be generalized to integrals involving other special functions. This class of integrals also proves useful in the electrostatic problems in which dielectric spheres are involved, which is of importance in modeling the dynamics of biological macromolecules. In fact, with this solution, a more robust foundation is laid for the Generalized Born method in modeling the dynamics of biomolecules. c2003 Elsevier B.V. All rights reserved.

Aircraft Avionics Suitable for Advanced Approach Applications. Volume 1. Aircraft Fleet Equipage.

DTIC Science & Technology

1986-07-01

have much greater display flexibility based on the menu selected by the crew and must be treated separately. Figures 2-1 through 2-10 present the...610, AD-611, ANS-31 Auto Pilot - 32* - AP-105 Flight Director - 30* - FD-108 IFC - 68 - SPZ 200, STARS/SPI 400/500, KFC -300, FCS-80 Radar 30 70 - RDR...SPZ 200A/STARS/SI, KFC -300, CENTURY IV Radar 24 76 - WXR-300, RDR-130, Primus, RDR-160, RDR-150, RDR-1300, AVQ-55, RDR-140, RDR-1200, AVQ-21, KWX-50

BIM-Based E-Procurement: An Innovative Approach to Construction E-Procurement

PubMed Central

2015-01-01

This paper presents an innovative approach to e-procurement in construction, which uses building information models (BIM) to support the construction procurement process. The result is an integrated and electronic instrument connected to a rich knowledge base capable of advanced operations and able to strengthen transaction relationships and collaboration throughout the supply chain. The BIM-based e-procurement prototype has been developed using distinct existing electronic solutions and an IFC server and was tested in a pilot case study, which supported further discussions of the results of the research. PMID:26090518

Juvenile Idiopathic Arthritis

MedlinePlus

... your doctor may prescribe other medications such as methotrexate. In addition, treatment options now include a newer class of medications ... About Us Contact Us Partners Editorial Policy Permissions ... For specific medical advice, diagnoses, and treatment, consult your doctor. © 1995- The Nemours Foundation. All ...

From Proposal Writing to Data Collection to Presentation: Physical Oceanography Laboratory Class Students Explore the Fundamentals of Science

NASA Astrophysics Data System (ADS)

Buijsman, M. C.; Church, I.; Haydel, J.; Martin, K. M.; Shiller, A. M.; Wallace, D. J.; Blancher, J.; Foltz, A.; Griffis, A. M.; Kosciuch, T. J.; Kincketootle, A.; Pierce, E.; Young, V. A.

2016-02-01

To better prepare first-year Department of Marine Science MSc students of the University of Southern Mississippi for their science careers, we plan to execute a semester-long Physical Oceanography laboratory class that exposes the enrolled students to all aspects of interdisciplinary research: writing a proposal, planning a cruise, collecting and analyzing data, and presenting their results. Although some of these aspects may be taught in any such class, the incorporation of all these aspects makes this class unique.The fieldwork will be conducted by boat in the Rigolets in Louisiana, a 13-km long tidal strait up to 1 km wide connecting the Mississippi Sound with Lake Pontchartrain. The students have the opportunity to collect ADCP, CTD, multibeam sonar, sediment and water samples.A second novel characteristic of this class is that the instructor partnered with the Lake Pontchartrain Basin Foundation, a not for profit environmental advocacy group. The foundation will give an hour-long seminar on the natural history of the study area and its environmental problems. This information provides context for the students' research proposals and allows them to formulate research questions and hypotheses that connect their research objectives to societally relevant issues, such as coastal erosion, salt water intrusion, and water quality. The proposal writing and cruise planning is done in the first month of the 3.5-month long semester. In the second month two surveys are conducted. The remainder of the semester is spent on analysis and reporting. Whenever possible we teach Matlab for the students to use in their data analysis. In this presentation, we will report on the successes and difficulties associated with teaching such a multi-faceted class.

KSC-2012-2719

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, Astronaut Scholarship Foundation Chairman and Hall of Fame astronaut Charlie Duke speaks during the U.S. Astronaut Hall of Fame induction ceremony. Space shuttle astronauts Franklin Chang Diaz, Kevin Chilton and Charlie Precourt were inducted into the Hall of Fame Class of 2012. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

KSC-2012-2726

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, Astronaut Scholarship Foundation Chairman and Hall of Fame astronaut Charlie Duke inducts shuttle astronaut Kevin Chilton into the U.S. Astronaut Hall of Fame Class of 2012 during the induction ceremony. Shuttle astronauts Franklin Chang Diaz and Charlie Precourt also were inducted into the Hall of Fame. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

KSC-2012-2731

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, Astronaut Scholarship Foundation Chairman and Hall of Fame astronaut Charlie Duke inducts shuttle astronaut Charlie Precourt into the U.S. Astronaut Hall of Fame Class of 2012 during the induction ceremony. Shuttle astronauts Franklin Chang Diaz and Kevin Chilton also were inducted into the Hall of Fame. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

Substance use predictors of victimization profiles among homeless youth: a latent class analysis.

PubMed

Bender, Kimberly; Thompson, Sanna; Ferguson, Kristin; Langenderfer, Lisa

2014-02-01

Although a substantial body of literature demonstrates high prevalence of street victimization among homeless youth, few studies have investigated the existence of victimization classes that differ on the type and frequency of victimization experienced. Nor do we know how substance use patterns relate to victimization classes. Using latent class analysis (LCA), we examined the existence of victimization classes of homeless youth and investigated substance use predictors of class membership utilizing a large purposive sample (N=601) recruited from homeless youth-serving host agencies in three disparate regions of the U.S. Results of the LCA suggest the presence of three distinct victimization profiles - youth fit into a low-victimization class, a witness class, or a high-victimization class. These three victimization classes demonstrated differences in their substance use, including rates of substance abuse/dependence on alcohol and/or drugs. The presence of distinct victimization profiles suggests the need for screening and referral for differential services. Copyright © 2013 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Network reconfiguration and working memory impairment in mesial temporal lobe epilepsy.

PubMed

Campo, Pablo; Garrido, Marta I; Moran, Rosalyn J; García-Morales, Irene; Poch, Claudia; Toledano, Rafael; Gil-Nagel, Antonio; Dolan, Raymond J; Friston, Karl J

2013-05-15

Mesial temporal lobe epilepsy (mTLE) is the most prevalent form of focal epilepsy, and hippocampal sclerosis (HS) is considered the most frequent associated pathological finding. Recent connectivity studies have shown that abnormalities, either structural or functional, are not confined to the affected hippocampus, but can be found in other connected structures within the same hemisphere, or even in the contralesional hemisphere. Despite the role of hippocampus in memory functions, most of these studies have explored network properties at resting state, and in some cases compared connectivity values with neuropsychological memory scores. Here, we measured magnetoencephalographic responses during verbal working memory (WM) encoding in left mTLE patients and controls, and compared their effective connectivity within a frontotemporal network using dynamic causal modelling. Bayesian model comparison indicated that the best model included bilateral, forward and backward connections, linking inferior temporal cortex (ITC), inferior frontal cortex (IFC), and the medial temporal lobe (MTL). Test for differences in effective connectivity revealed that patients exhibited decreased ipsilesional MTL-ITC backward connectivity, and increased bidirectional IFC-MTL connectivity in the contralesional hemisphere. Critically, a negative correlation was observed between these changes in patients, with decreases in ipsilesional coupling among temporal sources associated with increases contralesional frontotemporal interactions. Furthermore, contralesional frontotemporal interactions were inversely related to task performance and level of education. The results demonstrate that unilateral sclerosis induced local and remote changes in the dynamic organization of a distributed network supporting verbal WM. Crucially, pre-(peri) morbid factors (educational level) were reflected in both cognitive performance and (putative) compensatory changes in physiological coupling. Copyright © 2013 Elsevier Inc. All rights reserved.

Deep brain stimulation of the subthalamic nucleus alters the cortical profile of response inhibition in the beta frequency band: a scalp EEG study in Parkinson's disease

PubMed Central

Swann, Nicole; Poizner, Howard; Houser, Melissa; Gould, Sherrie; Greenhouse, Ian; Cai, Weidong; Strunk, Jon; George, Jobi; Aron, Adam R

2011-01-01

Stopping an initiated response could be implemented by a fronto-basal-ganglia circuit, including the right inferior frontal cortex (rIFC) and the subthalamic nucleus (STN). Intracranial recording studies in humans reveal an increase in beta-band power (~16-20 Hz) within the rIFC and STN when a response is stopped. This suggests that the beta-band could be important for communication in this network. If this is the case, then altering one region should affect the electrophysiological response at the other. We addressed this hypothesis by recording scalp EEG during a stop task while modulating STN activity with deep brain stimulation. We studied 15 human patients with Parkinson's Disease and 15 matched healthy control subjects. Behaviorally, patients OFF stimulation were slower than controls to stop their response. Moreover, stopping speed was improved for ON compared to OFF stimulation. For scalp EEG, there was greater beta power, around the time of stopping, for patients ON compared to OFF stimulation. This effect was stronger over the right compared to left frontal cortex, consistent with the putative right-lateralization of the stopping network. Thus, deep brain stimulation of the STN improved behavioral stopping performance and increased the beta-band response over the right frontal cortex. These results complement other evidence for a structurally-connected, functional, circuit between right frontal cortex and the basal ganglia. The results also suggest that deep brain stimulation of the STN may improve task performance by increasing the fidelity of information transfer within a fronto-basal ganglia circuit. PMID:21490213

Aging and inhibitory control of action: cortico-subthalamic connection strength predicts stopping performance.

PubMed

Coxon, James P; Van Impe, Annouchka; Wenderoth, Nicole; Swinnen, Stephan P

2012-06-13

Diffusion weighted imaging (DWI) studies in humans have shown that seniors exhibit reduced white matter integrity compared with young adults, with the most pronounced change occurring in frontal white matter. It is generally assumed that this structural deterioration underlies inhibitory control deficits in old age, but specific evidence from a structural neuroscience perspective is lacking. Cognitive action control is thought to rely on an interconnected network consisting of right inferior frontal cortex (r-IFC), pre-supplementary motor area (preSMA), and the subthalamic nucleus (STN). Here we performed probabilistic DWI tractography to delineate this cognitive control network and had the same individuals (20 young, 20 older adults) perform a task probing both response inhibition and action reprogramming. We hypothesized that structural integrity (fractional anisotropy) and connection strength within this network would be predictive of individual and age-related differences in task performance. We show that the integrity of r-IFC white matter is an age-independent predictor of stop-signal reaction time (SSRT). We further provide evidence that the integrity of white matter projecting to STN predicts both outright stopping (SSRT) and transient braking of response initiation to buy time for action reprogramming (stopping interference effects). These associations remain even after controlling for Go task performance, demonstrating specificity to the Stop component of this task. Finally, a multiple regression analysis reveals bilateral preSMA-STN tract strength as a significant predictor of SSRT in older adults. Our data link age-related decline in inhibitory control with structural decline of STN projections.

Exploitation of Semantic Building Model in Indoor Navigation Systems

NASA Astrophysics Data System (ADS)

Anjomshoaa, A.; Shayeganfar, F.; Tjoa, A. Min

2009-04-01

There are many types of indoor and outdoor navigation tools and methodologies available. A majority of these solutions are based on Global Positioning Systems (GPS) and instant video and image processing. These approaches are ideal for open world environments where very few information about the target location is available, but for large scale building environments such as hospitals, governmental offices, etc the end-user will need more detailed information about the surrounding context which is especially important in case of people with special needs. This paper presents a smart indoor navigation solution that is based on Semantic Web technologies and Building Information Model (BIM). The proposed solution is also aligned with Google Android's concepts to enlighten the realization of results. Keywords: IAI IFCXML, Building Information Model, Indoor Navigation, Semantic Web, Google Android, People with Special Needs 1 Introduction Built environment is a central factor in our daily life and a big portion of human life is spent inside buildings. Traditionally the buildings are documented using building maps and plans by utilization of IT tools such as computer-aided design (CAD) applications. Documenting the maps in an electronic way is already pervasive but CAD drawings do not suffice the requirements regarding effective building models that can be shared with other building-related applications such as indoor navigation systems. The navigation in built environment is not a new issue, however with the advances in emerging technologies like GPS, mobile and networked environments, and Semantic Web new solutions have been suggested to enrich the traditional building maps and convert them to smart information resources that can be reused in other applications and improve the interpretability with building inhabitants and building visitors. Other important issues that should be addressed in building navigation scenarios are location tagging and end-user communication. The available solutions for location tagging are mostly based on proximity sensors and the information are bound to sensor references. In the proposed solution of this paper, the sensors simply play a role similar to annotations in Semantic Web world. Hence the sensors data in ontology sense bridges the gap between sensed information and building model. Combining these two and applying the proper inference rules, the building visitors will be able to reach their destinations with instant support of their communication devices such as hand helds, wearable computers, mobiles, etc. In a typical scenario of this kind, user's profile will be delivered to the smart building (via building ad-hoc services) and the appropriate route for user will be calculated and delivered to user's end-device. The calculated route is calculated by considering all constraints and requirements of the end user. So for example if the user is using a wheelchair, the calculated route should not contain stairs or narrow corridors that the wheelchair does not pass through. Then user starts to navigate through building by following the instructions of the end-device which are in turn generated from the calculated route. During the navigation process, the end-device should also interact with the smart building to sense the locations by reading the surrounding tags. So for example when a visually impaired person arrives at an unknown space, the tags will be sensed and the relevant information will be delivered to user in the proper way of communication. For example the building model can be used to generate a voice message for a blind person about a space and tell him/her that "the space has 3 doors, and the door on the left should be chosen which needs to be pushed to open". In this paper we will mainly focus on automatic generation of semantic building information models (Semantic BIM) and delivery of results to the end user. Combining the building information model with the environment and user constraints using Semantic Web technologies will make many scenarios conceivable. The generated IFC ontology that is base on the commonly accepted IFC (Industry Foundation Classes) standard can be used as the basis of information sharing between buildings, people, and applications. The proposed solution is aiming to facilitate the building navigation in an intuitive and extendable way that is easy to use by end-users and at the same time easy to maintain and manage by building administrators.

Non-Abelian Bosonization and Fractional Quantum Hall Transitions

NASA Astrophysics Data System (ADS)

Hui, Aaron; Mulligan, Michael; Kim, Eun-Ah

A fully satisfying theoretical description for the quantum phase transition between fractional quantum Hall plateaus remains an outstanding problem. Experiments indicate scaling exponents that are not readily obtained in conventional theories. Using insights from duality, we describe a class of quantum critical effective theories that produce qualitatively realistic scaling exponents for the transition. We discuss the implications of our results for the physically-relevant interactions controlling this broad class of quantum critical behavior. Supported by National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1650441.

Embedding Engaged Learning in High Enrollment Lecture-Based Classes

ERIC Educational Resources Information Center

Lund Dean, Kathy; Wright, Sarah

2017-01-01

Engaged learning opportunities have become powerful foundations upon which students build lifelong skills and organizational capacities. Research has empirically validated the long-term positive learning impacts of active and experiential learning opportunities for students. As such, institutional administrators and external stakeholders have…

Conversing Cooperatively: Using "Mini-Conversations" to Develop Conversational Knowledge and Skill

ERIC Educational Resources Information Center

Jones, Elizabeth B.

2017-01-01

Courses: Interpersonal communication, relational communication, language and social interaction, professional communication, interviewing practices. Objectives: This single class activity enables students to understand the theoretical foundations of conversation and to develop their conversational skills by talking in dyads with classmates. Upon…

Continuation Methods for Qualitative Analysis of Aircraft Dynamics

NASA Technical Reports Server (NTRS)

Cummings, Peter A.

2004-01-01

A class of numerical methods for constructing bifurcation curves for systems of coupled, non-linear ordinary differential equations is presented. Foundations are discussed, and several variations are outlined along with their respective capabilities. Appropriate background material from dynamical systems theory is presented.

On-Campus Projects: Inventing a Microchip.

ERIC Educational Resources Information Center

Basta, Nicholas

1985-01-01

In response to growth of microelectronics and changes in microchip design/manufacturing technology, universities are supporting class projects for students. Approximately 50 schools now conduct such programs which have resulted from earlier National Science Foundation sponsorship. Major advantages for the students include designing experience,…

Value Added

ERIC Educational Resources Information Center

Welch, Matt

2004-01-01

This article profiles retiring values teacher Gene Doxey and describes his foundational contributions to the students of California's Ramona Unified School District. Every one of the Ramona Unified School District's 7,200 students is eventually funneled through Doxey's Contemporary Issues class, a required rite of passage between elementary school…

BOREAS RSS-3 Reflectance Measured from a Helicopter-Mounted Barnes MMR

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Walthall, Charles L.; Loechel, Sara; deColstoun, Eric Brown

2000-01-01

The BOREAS RSS-3 team acquired helicopter-based radiometric measurements of forested sites with a Barnes MMR. The data were collected in 1994 during the three BOREAS IFCs at numerous tower and auxiliary sites in both the NSA and SSA. The 15-degree FOV of the MMR yielded approximately 79-m ground resolution from an altitude of 300 m. The MMR has seven spectral bands that are similar to the Landsat TM bands, ranging from the blue region to the thermal. The data are stored in tabular ASCII files. The data are stored in tabular ASCII files.

BOREAS RSS-3 Reflectance Measured from a Helicopter-Mounted SE-590

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Walthall, Charles L.; Loechel, Sara

2000-01-01

The BOREAS RSS-3 team collected multiple remotely sensed data sets from the NASA UH-1 helicopter. This data set includes helicopter-based radiometric measurements of forested sites acquired during BOREAS made with an SE-590 processed to reflectance factors. The data used in this analysis were collected in 1994 during the three BOREAS IFCs at numerous tower and auxiliary sites in both the NSA and the SSA. The 15-degree FOV of the SE-590 yielded a ground resolution of approximately 79 m at the 300-m nominal altitude. The data are provided in tabular ASCII files.

BOREAS RSS-3 Atmospheric Measurements from a Helicopter-Mounted Sunphotometer

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Nickerson, Jaime (Editor); Walthall, Charles L.; Loechel, Sara; Halthore, Rangasayi

2000-01-01

The BOREAS RSS-3 team collected and processed helicopter-based measurements of atmospheric conditions to estimates of aerosol optical thickness and atmospheric water vapor. The automatic sun-tracking photometer for helicopters was deployed during all three 1994 IFCs at numerous tower and auxiliary sites in both the NSA and the SSA. Six spectral channels (440, 540, 613, 670, 870, and 1030 nm) were chosen to span the visible and NIR wavelengths and to avoid gaseous absorption. One additional channel, 940 nm, was selected to measure the water column abundance above the helicopter platform. The data are stored in tabular ASCII files.

Trajectories of Microbial Community Function in Response to Accelerated Remediation of Subsurface Metal Contaminants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Firestone, Mary

Objectives of proposed research were to; Determine if the trajectories of microbial community composition and function following organic carbon amendment can be related to, and predicted by, key environmental determinants; Assess the relative importance of the characteristics of the indigenous microbial community, sediment, groundwater, and concentration of organic carbon amendment as the major determinants of microbial community functional response and bioremediation capacity; and Provide a fundamental understanding of the microbial community ecology underlying subsurface metal remediation requisite to successful application of accelerated remediation and long-term stewardship of DOE-IFC sites.

Rich Imaginations

ERIC Educational Resources Information Center

Freedman, Jonathan

2009-01-01

The story of Bernard Madoff rivals outrageous fiction. It was astonishing that this seemingly kindly, respectable financier, a pioneer in electronic trading, a founding partner in the Nasdaq exchange, turned out to have been running a $65-billion Ponzi scheme that victimized country-club elites, middle-class retirees, foundations, universities,…

Weaving Social Foundations through Dance Pedagogy: A Pedagogy of Uncovering

ERIC Educational Resources Information Center

Barr, Sherrie; Risner, Doug

2014-01-01

Today's dance educators enter classrooms populated by increasingly diverse students in which teachers' pedagogical knowledge necessitates heightened understandings of race, ethnicity, social class, gender, and sexuality. Uncovering taken-for-granted assumptions, dominant stereotypes, and educational structures that reproduce social…

A Toolkit for Active Object-Oriented Databases with Application to Interoperability

NASA Technical Reports Server (NTRS)

King, Roger

1996-01-01

In our original proposal we stated that our research would 'develop a novel technology that provides a foundation for collaborative information processing.' The essential ingredient of this technology is the notion of 'deltas,' which are first-class values representing collections of proposed updates to a database. The Heraclitus framework provides a variety of algebraic operators for building up, combining, inspecting, and comparing deltas. Deltas can be directly applied to the database to yield a new state, or used 'hypothetically' in queries against the state that would arise if the delta were applied. The central point here is that the step of elevating deltas to 'first-class' citizens in database programming languages will yield tremendous leverage on the problem of supporting updates in collaborative information processing. In short, our original intention was to develop the theoretical and practical foundation for a technology based on deltas in an object-oriented database context, develop a toolkit for active object-oriented databases, and apply this toward collaborative information processing.

A Toolkit for Active Object-Oriented Databases with Application to Interoperability

NASA Technical Reports Server (NTRS)

King, Roger

1996-01-01

In our original proposal we stated that our research would 'develop a novel technology that provides a foundation for collaborative information processing.' The essential ingredient of this technology is the notion of 'deltas,' which are first-class values representing collections of proposed updates to a database. The Heraclitus framework provides a variety of algebraic operators for building up, combining, inspecting, and comparing deltas. Deltas can be directly applied to the database to yield a new state, or used 'hypothetically' in queries against the state that would arise if the delta were applied. The central point here is that the step of elevating deltas to 'first-class' citizens in database programming languages will yield tremendous leverage on the problem of supporting updates in collaborative information processing. In short, our original intention was to develop the theoretical and practical foundation for a technology based on deltas in an object- oriented database context, develop a toolkit for active object-oriented databases, and apply this toward collaborative information processing.

Transition-Independent Decentralized Markov Decision Processes

NASA Technical Reports Server (NTRS)

Becker, Raphen; Silberstein, Shlomo; Lesser, Victor; Goldman, Claudia V.; Morris, Robert (Technical Monitor)

2003-01-01

There has been substantial progress with formal models for sequential decision making by individual agents using the Markov decision process (MDP). However, similar treatment of multi-agent systems is lacking. A recent complexity result, showing that solving decentralized MDPs is NEXP-hard, provides a partial explanation. To overcome this complexity barrier, we identify a general class of transition-independent decentralized MDPs that is widely applicable. The class consists of independent collaborating agents that are tied up by a global reward function that depends on both of their histories. We present a novel algorithm for solving this class of problems and examine its properties. The result is the first effective technique to solve optimally a class of decentralized MDPs. This lays the foundation for further work in this area on both exact and approximate solutions.

KSC-2012-2721

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, Astronaut Scholarship Foundation Chairman and Hall of Fame astronaut Charlie Duke inducts shuttle astronaut Franklin Chang Diaz into the U.S. Astronaut Hall of Fame Class of 2012. At the podium to the left, is CNN correspondent and Master of Ceremonies John Zarrella. Also inducted into the Hall of Fame were shuttle astronauts Kevin Chilton and Charlie Precourt. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

KSC-2012-2720

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, Astronaut Scholarship Foundation Chairman and Hall of Fame astronaut Charlie Duke spoke during the U.S. Astronaut Hall of Fame induction ceremony and recognized former shuttle launch director Bob Sieck. Space shuttle astronauts Franklin Chang Diaz, Kevin Chilton and Charlie Precourt were inducted into the Hall of Fame Class of 2012. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

KSC-2012-2722

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, space shuttle astronaut and U.S. Astronaut Hall of Fame Class of 2012 inductee Franklin Chang Diaz at right shares a humorous moment with Astronaut Scholarship Foundation Chairman and Hall of Fame astronaut Charlie Duke during the induction ceremony. Shuttle astronauts Kevin Chilton and Charlie Precourt also were inducted into the Hall of Fame. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

Improving student learning in calculus through applications

NASA Astrophysics Data System (ADS)

Young, C. Y.; Georgiopoulos, M.; Hagen, S. C.; Geiger, C. L.; Dagley-Falls, M. A.; Islas, A. L.; Ramsey, P. J.; Lancey, P. M.; Straney, R. A.; Forde, D. S.; Bradbury, E. E.

2011-07-01

Nationally only 40% of the incoming freshmen Science, Technology, Engineering and Mathematics (STEM) majors are successful in earning a STEM degree. The University of Central Florida (UCF) EXCEL programme is a National Science Foundation funded STEM Talent Expansion Programme whose goal is to increase the number of UCF STEM graduates. One of the key requirements for STEM majors is a strong foundation in Calculus. To improve student learning in calculus, the EXCEL programme developed two special courses at the freshman level called Applications of Calculus I (Apps I) and Applications of Calculus II (Apps II). Apps I and II are one-credit classes that are co-requisites for Calculus I and II. These classes are teams taught by science and engineering professors whose goal is to demonstrate to students where the calculus topics they are learning appear in upper level science and engineering classes as well as how faculty use calculus in their STEM research programmes. This article outlines the process used in producing the educational materials for the Apps I and II courses, and it also discusses the assessment results pertaining to this specific EXCEL activity. Pre- and post-tests conducted with experimental and control groups indicate significant improvement in student learning in Calculus II as a direct result of the application courses.

Nuclear power and probabilistic safety assessment (PSA): past through future applications

NASA Astrophysics Data System (ADS)

Stamatelatos, M. G.; Moieni, P.; Everline, C. J.

1995-03-01

Nuclear power reactor safety in the United States is about to enter a new era -- an era of risk- based management and risk-based regulation. First, there was the age of `prescribed safety assessment,' during which a series of design-basis accidents in eight categories of severity, or classes, were postulated and analyzed. Toward the end of that era, it was recognized that `Class 9,' or `beyond design basis,' accidents would need special attention because of the potentially severe health and financial consequences of these accidents. The accident at Three Mile Island showed that sequences of low-consequence, high-frequency events and human errors can be much more risk dominant than the Class 9 accidents. A different form of safety assessment, PSA, emerged and began to gain ground against the deterministic safety establishment. Eventually, this led to the current regulatory requirements for individual plant examinations (IPEs). The IPEs can serve as a basis for risk-based regulation and management, a concept that may ultimately transform the U.S. regulatory process from its traditional deterministic foundations to a process predicated upon PSA. Beyond the possibility of a regulatory environment predicated upon PSA lies the possibility of using PSA as the foundation for managing daily nuclear power plant operations.

45 CFR 690.124 - Conditions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false Conditions. 690.124 Section 690.124 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.124 Conditions. With respect to any research project or any class of research projects the...

45 CFR 690.124 - Conditions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Conditions. 690.124 Section 690.124 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.124 Conditions. With respect to any research project or any class of research projects the...

45 CFR 690.124 - Conditions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Conditions. 690.124 Section 690.124 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.124 Conditions. With respect to any research project or any class of research projects the...

The Ram's Horn, Volume IV, 1986-1987.

ERIC Educational Resources Information Center

Rassias Foundation, Dartmouth, NH.

This annual publication of the Rassias Foundation at Dartmouth College (New Hampshire) includes these articles and commentaries: "Clio and Hermes: Languages in the Study of the Past" (Kent J. Rigsby); "The Micrologue in a Student-Directed Conversation Class" (Stephen A. Canfield); "Baby Pictures and the Spanish Preterit…

77 FR 25692 - Marine Mammals; File No. 16479

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

...], 300 Maalaea Road, Suite 211, Wailuku, HI 96793, has requested a change in Principal Investigator to..., environmental variables, vessel behavior, whale abundance, and individual sex and age classes. Up to 567... activities. Under the pending permit application, The Pacific Whale Foundation is requesting a change in...

Teaching Natural History in a Wilderness Setting.

ERIC Educational Resources Information Center

Vause, Mikel

A college honors course called "A Field Study in American Literature and Philosophy" helps students develop foundations for an environmental philosophy, by introducing them to the literature of natural history and exploration, and more importantly, through actual participation in outdoor activities. The class spends at least four days…

45 CFR 690.124 - Conditions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Conditions. 690.124 Section 690.124 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.124 Conditions. With respect to any research project or any class of research projects the...

45 CFR 690.124 - Conditions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Conditions. 690.124 Section 690.124 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.124 Conditions. With respect to any research project or any class of research projects the...

Fractions We Cannot Ignore: The Nonsymbolic Ratio Congruity Effect

ERIC Educational Resources Information Center

Matthews, Percival G.; Lewis, Mark R.

2017-01-01

Although many researchers theorize that primitive numerosity processing abilities may lay the foundation for whole number concepts, other classes of numbers, like fractions, are sometimes assumed to be inaccessible to primitive architectures. This research presents evidence that the automatic processing of nonsymbolic magnitudes affects processing…

Girls Disengage from High School Science

ERIC Educational Resources Information Center

Education Digest: Essential Readings Condensed for Quick Review, 2010

2010-01-01

High school girls are bored, disengaged, and stressed in science classes, according to preliminary results of a study led by Northern Illinois University researchers Jennifer Schmidt and M. Cecil Smith. The two professors in the College of Education's Department of Leadership, Educational Psychology, and Foundations studied 244 high school…

Technology for Science: Overview of the Project.

ERIC Educational Resources Information Center

Crismond, David; And Others

Technology for Science is a National Science Foundation funded program that is developing and testing curriculum units for teacher materials built around a series of design-oriented science problems called "challenges," mainly for ninth-grade general and physical science classes. Technology for science challenges have a clear connection…

Flipping to Teach the Conceptual Foundations of Successful Workplace Writing

ERIC Educational Resources Information Center

Campbell, Kim Sydow

2016-01-01

Flipping originated in science, technology, engineering, and mathematics fields, where didactic transmission of conceptual knowledge has been the standard pedagogy. Flipping has resulted in additional focus on procedural knowledge within class meetings. This article argues that business and professional writing pedagogy, which already focuses…

Star Students Make Connections

ERIC Educational Resources Information Center

Marshall, Anne Marie; Superfine, Alison Castro; Canty, Reality S.

2010-01-01

Ms. Beyer's first graders have been working for several weeks on solving problems that encourage the use of such multiple representations as ten frames and number lines. The class is using Math Trailblazers, a National Science Foundation-supported elementary school math curriculum developed to reflect recent reform efforts in mathematics…

The relationship between recollection, knowledge transfer, and student attitudes towards chemistry

NASA Astrophysics Data System (ADS)

Odeleye, Oluwatobi Omobonike

Certain foundational concepts, including acid-base theory, chemical bonding and intermolecular forces (IMFs), appear throughout the undergraduate chemistry curriculum. The level of understanding of these foundational concepts influences the ability of students to recognize the relationships between sub-disciplines in chemistry. The purpose of this study was to investigate the relationship between student attitudes towards chemistry and their abilities to recollect and transfer knowledge of IMFs, a foundational concept, to their daily lives as well as to other classes. Data were collected using surveys, interviews and classroom observations, and analyzed using qualitative methods. The data show that while most students were able to function at lower levels of thinking by providing a definition of IMFs, majority were unable to function at higher levels of thinking as evidenced by their inability to apply their knowledge of IMFs to their daily lives and other classes. The results of this study suggest a positive relationship between students' abilities to recollect knowledge and their abilities to transfer that knowledge. The results also suggest positive relationships between recollection abilities of students and their attitudes towards chemistry as well as their transfer abilities and attitudes towards chemistry. Recommendations from this study include modifications of pedagogical techniques in ways that facilitate higher-level thinking and emphasize how chemistry applies not only to daily life, but also to other courses.

Developmental changes of neuronal networks associated with strategic social decision-making.

PubMed

Steinmann, Elisabeth; Schmalor, Antonia; Prehn-Kristensen, Alexander; Wolff, Stephan; Galka, Andreas; Möhring, Jan; Gerber, Wolf-Dieter; Petermann, Franz; Stephani, Ulrich; Siniatchkin, Michael

2014-04-01

One of the important prerequisites for successful social interaction is the willingness of each individual to cooperate socially. Using the ultimatum game, several studies have demonstrated that the process of decision-making to cooperate or to defeat in interaction with a partner is associated with activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), anterior insula (AI), and inferior frontal cortex (IFC). This study investigates developmental changes in this neuronal network. 15 healthy children (8-12 years), 15 adolescents (13-18 years) and 15 young adults (19-28 years) were investigated using the ultimatum game. Neuronal networks representing decision-making based on strategic thinking were characterized using functional MRI. In all age groups, the process of decision-making in reaction to unfair offers was associated with hemodynamic changes in similar regions. Compared with children, however, healthy adults and adolescents revealed greater activation in the IFC and the fusiform gyrus, as well as the nucleus accumbens. In contrast, healthy children displayed more activation in the AI, the dorsal part of the ACC, and the DLPFC. There were no differences in brain activations between adults and adolescents. The neuronal mechanisms underlying strategic social decision making are already developed by the age of eight. Decision-making based on strategic thinking is associated with age-dependent involvement of different brain regions. Neuronal networks underlying theory of mind and reward anticipation are more activated in adults and adolescents with regard to the increasing perspective taking with age. In relation to emotional reactivity and respective compensatory coping in younger ages, children have higher activations in a neuronal network associated with emotional processing and executive control. Copyright © 2014 Elsevier Ltd. All rights reserved.

Genome-Scale, Constraint-Based Modeling of Nitrogen Oxide Fluxes during Coculture of Nitrosomonas europaea and Nitrobacter winogradskyi

PubMed Central

Giguere, Andrew T.; Murthy, Ganti S.; Bottomley, Peter J.; Sayavedra-Soto, Luis A.

2018-01-01

ABSTRACT Nitrification, the aerobic oxidation of ammonia to nitrate via nitrite, emits nitrogen (N) oxide gases (NO, NO2, and N2O), which are potentially hazardous compounds that contribute to global warming. To better understand the dynamics of nitrification-derived N oxide production, we conducted culturing experiments and used an integrative genome-scale, constraint-based approach to model N oxide gas sources and sinks during complete nitrification in an aerobic coculture of two model nitrifying bacteria, the ammonia-oxidizing bacterium Nitrosomonas europaea and the nitrite-oxidizing bacterium Nitrobacter winogradskyi. The model includes biotic genome-scale metabolic models (iFC578 and iFC579) for each nitrifier and abiotic N oxide reactions. Modeling suggested both biotic and abiotic reactions are important sources and sinks of N oxides, particularly under microaerobic conditions predicted to occur in coculture. In particular, integrative modeling suggested that previous models might have underestimated gross NO production during nitrification due to not taking into account its rapid oxidation in both aqueous and gas phases. The integrative model may be found at https://github.com/chaplenf/microBiome-v2.1. IMPORTANCE Modern agriculture is sustained by application of inorganic nitrogen (N) fertilizer in the form of ammonium (NH4+). Up to 60% of NH4+-based fertilizer can be lost through leaching of nitrifier-derived nitrate (NO3−), and through the emission of N oxide gases (i.e., nitric oxide [NO], N dioxide [NO2], and nitrous oxide [N2O] gases), the latter being a potent greenhouse gas. Our approach to modeling of nitrification suggests that both biotic and abiotic mechanisms function as important sources and sinks of N oxides during microaerobic conditions and that previous models might have underestimated gross NO production during nitrification. PMID:29577088

Dynamic oscillatory processes governing cued orienting and allocation of auditory attention

PubMed Central

Ahveninen, Jyrki; Huang, Samantha; Belliveau, John W.; Chang, Wei-Tang; Hämäläinen, Matti

2013-01-01

In everyday listening situations, we need to constantly switch between alternative sound sources and engage attention according to cues that match our goals and expectations. The exact neuronal bases of these processes are poorly understood. We investigated oscillatory brain networks controlling auditory attention using cortically constrained fMRI-weighted magnetoencephalography/ electroencephalography (MEG/EEG) source estimates. During consecutive trials, subjects were instructed to shift attention based on a cue, presented in the ear where a target was likely to follow. To promote audiospatial attention effects, the targets were embedded in streams of dichotically presented standard tones. Occasionally, an unexpected novel sound occurred opposite to the cued ear, to trigger involuntary orienting. According to our cortical power correlation analyses, increased frontoparietal/temporal 30–100 Hz gamma activity at 200–1400 ms after cued orienting predicted fast and accurate discrimination of subsequent targets. This sustained correlation effect, possibly reflecting voluntary engagement of attention after the initial cue-driven orienting, spread from the temporoparietal junction, anterior insula, and inferior frontal (IFC) cortices to the right frontal eye fields. Engagement of attention to one ear resulted in a significantly stronger increase of 7.5–15 Hz alpha in the ipsilateral than contralateral parieto-occipital cortices 200–600 ms after the cue onset, possibly reflecting crossmodal modulation of the dorsal visual pathway during audiospatial attention. Comparisons of cortical power patterns also revealed significant increases of sustained right medial frontal cortex theta power, right dorsolateral prefrontal cortex and anterior insula/IFC beta power, and medial parietal cortex and posterior cingulate cortex gamma activity after cued vs. novelty-triggered orienting (600–1400 ms). Our results reveal sustained oscillatory patterns associated with voluntary engagement of auditory spatial attention, with the frontoparietal and temporal gamma increases being best predictors of subsequent behavioral performance. PMID:23915050

Rhythmic and melodic deviations in musical sequences recruit different cortical areas for mismatch detection.

PubMed

Lappe, Claudia; Steinsträter, Olaf; Pantev, Christo

2013-01-01

The mismatch negativity (MMN), an event-related potential (ERP) representing the violation of an acoustic regularity, is considered as a pre-attentive change detection mechanism at the sensory level on the one hand and as a prediction error signal on the other hand, suggesting that bottom-up as well as top-down processes are involved in its generation. Rhythmic and melodic deviations within a musical sequence elicit a MMN in musically trained subjects, indicating that acquired musical expertise leads to better discrimination accuracy of musical material and better predictions about upcoming musical events. Expectation violations to musical material could therefore recruit neural generators that reflect top-down processes that are based on musical knowledge. We describe the neural generators of the musical MMN for rhythmic and melodic material after a short-term sensorimotor-auditory (SA) training. We compare the localization of musical MMN data from two previous MEG studies by applying beamformer analysis. One study focused on the melodic harmonic progression whereas the other study focused on rhythmic progression. The MMN to melodic deviations revealed significant right hemispheric neural activation in the superior temporal gyrus (STG), inferior frontal cortex (IFC), and the superior frontal (SFG) and orbitofrontal (OFG) gyri. IFC and SFG activation was also observed in the left hemisphere. In contrast, beamformer analysis of the data from the rhythm study revealed bilateral activation within the vicinity of auditory cortices and in the inferior parietal lobule (IPL), an area that has recently been implied in temporal processing. We conclude that different cortical networks are activated in the analysis of the temporal and the melodic content of musical material, and discuss these networks in the context of the dual-pathway model of auditory processing.

Complexes prepared from protein A and human serum, IgG, or Fc gamma fragments: characterization by immunochemical analysis of ultracentrifugation fractions and studies on their interconversion.

PubMed

Langone, J J; Das, C; Mainwaring, R; Shearer, W T

1985-01-01

Protein A of Staphylococcus aureus is an Fc receptor for IgG that has been used as a therapeutic reagent to treat cancer in humans and experimental animals. We used ultracentrifugation combined with analysis of isolated fractions by radioimmunoprecipitation and competitive radioimmunoassay with chicken antibodies that bind free protein A or protein A in complexes but do bind free immunoglobulin reagents to localize and characterize the types of complexes formed with different molar ratios of 125I-protein A and human 131I-IgG alone or in serum, and 131I-Fc gamma fragments. This approach offers a distinct advantage over direct counting of radioactivity in the fractions because resolution of complexes and free reagents is much improved. With excess 131I-IgG or 131I-Fc, all the 125I-protein A is present only in complexes that contained 4 molecules of immunoglobulin reagent and 2 molecules of protein A (4:2 complexes), whereas with excess 125I-protein A the stoichiometry of the complexes was 1:1. We have also shown the preformed 4:2 and 1:1 complexes will interconvert in the presence of added excess protein A or IgG, respectively, and that fresh IgG will exchange with IgG or Fc gamma in preformed complexes. Because protein A has been found to elute from an immobilized reagent used in serotherapy of human cancer and is present in a large excess of IgG, the 4:2 complexes may play an active role in the tumoricidal or toxic reactions observed.

Evaluating Multiple Levels of an Interaction Fidelity Continuum on Performance and Learning in Near-Field Training Simulations.

PubMed

Bhargava, Ayush; Bertrand, Jeffrey W; Gramopadhye, Anand K; Madathil, Kapil C; Babu, Sabarish V

2018-04-01

With costs of head-mounted displays (HMDs) and tracking technology decreasing rapidly, various virtual reality applications are being widely adopted for education and training. Hardware advancements have enabled replication of real-world interactions in virtual environments to a large extent, paving the way for commercial grade applications that provide a safe and risk-free training environment at a fraction of the cost. But this also mandates the need to develop more intrinsic interaction techniques and to empirically evaluate them in a more comprehensive manner. Although there exists a body of previous research that examines the benefits of selected levels of interaction fidelity on performance, few studies have investigated the constituent components of fidelity in a Interaction Fidelity Continuum (IFC) with several system instances and their respective effects on performance and learning in the context of a real-world skills training application. Our work describes a large between-subjects investigation conducted over several years that utilizes bimanual interaction metaphors at six discrete levels of interaction fidelity to teach basic precision metrology concepts in a near-field spatial interaction task in VR. A combined analysis performed on the data compares and contrasts the six different conditions and their overall effects on performance and learning outcomes, eliciting patterns in the results between the discrete application points on the IFC. With respect to some performance variables, results indicate that simpler restrictive interaction metaphors and highest fidelity metaphors perform better than medium fidelity interaction metaphors. In light of these results, a set of general guidelines are created for developers of spatial interaction metaphors in immersive virtual environments for precise fine-motor skills training simulations.

Genome-Scale, Constraint-Based Modeling of Nitrogen Oxide Fluxes during Coculture of Nitrosomonas europaea and Nitrobacter winogradskyi.

PubMed

Mellbye, Brett L; Giguere, Andrew T; Murthy, Ganti S; Bottomley, Peter J; Sayavedra-Soto, Luis A; Chaplen, Frank W R

2018-01-01

Nitrification, the aerobic oxidation of ammonia to nitrate via nitrite, emits nitrogen (N) oxide gases (NO, NO 2 , and N 2 O), which are potentially hazardous compounds that contribute to global warming. To better understand the dynamics of nitrification-derived N oxide production, we conducted culturing experiments and used an integrative genome-scale, constraint-based approach to model N oxide gas sources and sinks during complete nitrification in an aerobic coculture of two model nitrifying bacteria, the ammonia-oxidizing bacterium Nitrosomonas europaea and the nitrite-oxidizing bacterium Nitrobacter winogradskyi . The model includes biotic genome-scale metabolic models (iFC578 and iFC579) for each nitrifier and abiotic N oxide reactions. Modeling suggested both biotic and abiotic reactions are important sources and sinks of N oxides, particularly under microaerobic conditions predicted to occur in coculture. In particular, integrative modeling suggested that previous models might have underestimated gross NO production during nitrification due to not taking into account its rapid oxidation in both aqueous and gas phases. The integrative model may be found at https://github.com/chaplenf/microBiome-v2.1. IMPORTANCE Modern agriculture is sustained by application of inorganic nitrogen (N) fertilizer in the form of ammonium (NH 4 + ). Up to 60% of NH 4 + -based fertilizer can be lost through leaching of nitrifier-derived nitrate (NO 3 - ), and through the emission of N oxide gases (i.e., nitric oxide [NO], N dioxide [NO 2 ], and nitrous oxide [N 2 O] gases), the latter being a potent greenhouse gas. Our approach to modeling of nitrification suggests that both biotic and abiotic mechanisms function as important sources and sinks of N oxides during microaerobic conditions and that previous models might have underestimated gross NO production during nitrification.

Childhood maltreatment is associated with a sex-dependent functional reorganization of a brain inhibitory control network.

PubMed

Elton, Amanda; Tripathi, Shanti P; Mletzko, Tanja; Young, Jonathan; Cisler, Josh M; James, G Andrew; Kilts, Clinton D

2014-04-01

Childhood adversity represents a major risk factor for drug addiction and other mental disorders. However, the specific mechanisms by which childhood adversity impacts human brain organization to confer greater vulnerability for negative outcomes in adulthood is largely unknown. As an impaired process in drug addiction, inhibitory control of behavior was investigated as a target of childhood maltreatment (abuse and neglect). Forty adults without Axis-I psychiatric disorders (21 females) completed a Childhood Trauma Questionnaire (CTQ) and underwent functional MRI (fMRI) while performing a stop-signal task. A group independent component analysis identified a putative brain inhibitory control network. Graph theoretical analyses and structural equation modeling investigated the impact of childhood maltreatment on the functional organization of this neural processing network. Graph theory outcomes revealed sex differences in the relationship between network functional connectivity and inhibitory control which were dependent on the severity of childhood maltreatment exposure. A network effective connectivity analysis indicated that a maltreatment dose-related negative modulation of dorsal anterior cingulate (dACC) activity by the left inferior frontal cortex (IFC) predicted better response inhibition and lesser attention deficit hyperactivity disorder (ADHD) symptoms in females, but poorer response inhibition and greater ADHD symptoms in males. Less inhibition of the right IFC by dACC in males with higher CTQ scores improved inhibitory control ability. The childhood maltreatment-related reorganization of a brain inhibitory control network provides sex-dependent mechanisms by which childhood adversity may confer greater risk for drug use and related disorders and by which adaptive brain responses protect individuals from this risk factor. Copyright © 2013 Wiley Periodicals, Inc.

Numerical performance and throughput benchmark for electronic structure calculations in PC-Linux systems with new architectures, updated compilers, and libraries.

PubMed

Yu, Jen-Shiang K; Hwang, Jenn-Kang; Tang, Chuan Yi; Yu, Chin-Hui

2004-01-01

A number of recently released numerical libraries including Automatically Tuned Linear Algebra Subroutines (ATLAS) library, Intel Math Kernel Library (MKL), GOTO numerical library, and AMD Core Math Library (ACML) for AMD Opteron processors, are linked against the executables of the Gaussian 98 electronic structure calculation package, which is compiled by updated versions of Fortran compilers such as Intel Fortran compiler (ifc/efc) 7.1 and PGI Fortran compiler (pgf77/pgf90) 5.0. The ifc 7.1 delivers about 3% of improvement on 32-bit machines compared to the former version 6.0. Performance improved from pgf77 3.3 to 5.0 is also around 3% when utilizing the original unmodified optimization options of the compiler enclosed in the software. Nevertheless, if extensive compiler tuning options are used, the speed can be further accelerated to about 25%. The performances of these fully optimized numerical libraries are similar. The double-precision floating-point (FP) instruction sets (SSE2) are also functional on AMD Opteron processors operated in 32-bit compilation, and Intel Fortran compiler has performed better optimization. Hardware-level tuning is able to improve memory bandwidth by adjusting the DRAM timing, and the efficiency in the CL2 mode is further accelerated by 2.6% compared to that of the CL2.5 mode. The FP throughput is measured by simultaneous execution of two identical copies of each of the test jobs. Resultant performance impact suggests that IA64 and AMD64 architectures are able to fulfill significantly higher throughput than the IA32, which is consistent with the SpecFPrate2000 benchmarks.

Project Integration Architecture as a Foundation for Autonomous Solution Systems: The Postulation of a Meaningful "SolveYourself" Method

NASA Technical Reports Server (NTRS)

Jones, William Henry

2005-01-01

The Project Integration Architecture (PIA) uses object-oriented technology to implement self-revelation and semantic infusion through class derivation. That is, the kind of an object can be discovered through program inquiry and the well-known, well-defined meaning of that object can be utilized as a result of that discovery. This technology has already been demonstrated by the PIA effort in its parameter object classes. It is proposed that, by building on this technology, an autonomous, automatic, goal-seeking, solution system may be devised.

Introduction to a New Approach to Experiential Learning.

ERIC Educational Resources Information Center

Jackson, Lewis; MacIsaac, Doug

1994-01-01

A process model for experiential learning (EL) in adult education begins with the characteristics and needs of adult learners and conceptual foundations of EL. It includes methods and techniques for in-class and field-based experiences, building a folio (point-in-time performance assessment), and portfolio construction (assessing transitional…

Fuel Cell Car Design Project for Freshman Engineering Courses

ERIC Educational Resources Information Center

Duke, Steve R.; Davis, Virginia A.

2014-01-01

In the Samuel Ginn College of Engineering at Auburn University, we have integrated a semester long design project based on a toy fuel cell car into our freshman "Introduction to Chemical Engineering Class." The project provides the students a basic foundation in chemical reactions, energy, and dimensional analysis that facilitates…

Grounding the Flipped Classroom Approach in the Foundations of Educational Technology

ERIC Educational Resources Information Center

Lo, Chung Kwan

2018-01-01

The flipped classroom approach is becoming increasingly popular. This instructional approach allows more in-class time to be spent on interactive learning activities, as the direct lecturing component is shifted outside the classroom through instructional videos. However, despite growing interest in the flipped classroom approach, no robust…

Mexican-Americans of South Texas.

ERIC Educational Resources Information Center

Madsen, William

The Hogg Foundation for Mental Health sponsored and financed the Hidalgo Project on Differential Culture Change and Mental Health during the 4-year period from 1957 to 1961; this document is an abbreviated report of that study of Mexican-American culture in Hidalgo County, Texas. Acculturation levels of various classes of the Mexican-American…

Constructivism and Jewish Early Childhood Education

ERIC Educational Resources Information Center

Muller, Meir

2013-01-01

Having an educational theory as a school's foundation is a key component in successful educational endeavors. However, many Jewish early childhood programs do not commonly use educational theory to support methods of instruction. In this study 14 children from a constructivist-based Jewish kindergarten class are interviewed to determine how they…

A School of the Future...Today.

ERIC Educational Resources Information Center

Lincoln County School of Technology, Lincolnton, NC.

In an attempt to improve vocational education in Lincoln County, North Carolina, the Lincoln County School of Technology (LCST) was established by a partnership between a local foundation, the county Economic Development Commission, and the local community college, Gaston College. LCST is a magnet school, providing technical classes to local high…

Flipping the Foreign Language Classroom and Critical Pedagogies: A (New) Old Trend

ERIC Educational Resources Information Center

Correa, Maite

2015-01-01

Since the foundation of the Khan Academy (2006), a great deal of attention has been generated to the term "flipped classrooms" (also known as "reverse" or "backwards" classrooms), which is a (new) pedagogical movement that reverses the traditional paradigm of class lecture and homework. This approach subordinates…

The Instructional Guide for Abbott Skills Enhancement Classes. Revised Edition.

ERIC Educational Resources Information Center

Ballinger, Ronda; Gee, Mary Kay

This guide, which integrates adult basic education (ABE) curriculum, job skills for Abbott Laboratories, and work-related foundation skills, is designed for an instructional program in the skill areas of reading, writing, oral communications, mathematics, and problem solving. In addition to creating a uniform process and product to promote…

Reading and Talking about Books: A Critical Foundation for Intervention

ERIC Educational Resources Information Center

Wozniak, Cheryl L.

2011-01-01

Reluctant and struggling readers, many of whom are boys, are placed in reading intervention classes; however, often the environmental conditions of these intervention classrooms are not conducive for fostering a student's love for reading. This article describes Cambourne's optimal conditions for literacy learning and the results from implementing…

In the Valley of the Giants: Cultivating Intentionality and Integration

ERIC Educational Resources Information Center

Carey, Miriam

2012-01-01

This study examines the cultivation of intentionality and integration in a foundation level General Education class: Communities and Societies. Three research tasks were set within the context of a grounded theoretical approach: codification of indicators for both intentionality and integration, and an examination of student learning logs.…

Middle School and pH?

ERIC Educational Resources Information Center

Herricks, Susan

2007-01-01

A local middle school requested that the Water Center of Advanced Materials for Purification of Water With Systems (WaterCAMPWS), a National Science Foundation Science and Technology Center, provide an introduction to pH for their seventh-grade water-based service learning class. After sorting through a multitude of information about pH, a…

Survey of Graduating Seniors: Class of 1983.

ERIC Educational Resources Information Center

Gross, Susan

The Montgomery County Public Schools (MCPS) Department of Educational Accountability (DEA) administered a broad based survey to graduating seniors in MCPS high schools in May 1983. This first annual survey will be the foundation of a proposed longitudinal follow-up of graduates. The survey assessed students' perceptions of the educational program…

Using Literature Study Groups in Teacher Education Courses: Learning through Diversity.

ERIC Educational Resources Information Center

Roberts, Sherron Killingsworth; Jensen, Sharon J.; Hadjiyianni, Eleni

1997-01-01

Investigates the effectiveness of literature study groups with preservice teachers enrolled in a course on social foundations of American education. Describes introducing and using literature study groups in this class. Shows that 62% most liked "input from others"; 58% valued "gaining a variety of perspectives"; and 75%…

Using Your Strengths to Teach a Dance History Course

ERIC Educational Resources Information Center

Angier, D. Chase

2007-01-01

Letting the dance work itself educate the student and conducting related experiential classes is an important foundation on which to build readings, discussions, written assignments, and projects. Dance educators can design the educational investigations to be fueled directly from the art and support the investigation with contextual information.…

The Relationship between Voting Knowledge and Voting Attitudes of Selected Ninth and Tenth Grade Students.

ERIC Educational Resources Information Center

Golden, Kathleen

1985-01-01

A study showed that the acquisition of voting knowledge in a civics class positively influenced ninth- and tenth-grade students' attitudes toward voting. Teachers should give students a solid foundation concerning the electoral process and encourage students to participate in the political process. (RM)

Using Meditation in the Classroom.

ERIC Educational Resources Information Center

Moore, Michael C.

1992-01-01

One teacher's use of a form of meditation accompanied by music in a beginning Spanish class is reported. The approach taken was inspired by the theoretical foundation of Lozanov's Suggestopedia along with a simple exercise called "holding post" adapted from Tai Chi Chuan, an ancient Chinese martial art. (two references) (LB)

Engaging Students with Social Media

ERIC Educational Resources Information Center

Bal, Anjali S.; Grewal, Dhruv; Mills, Adam; Ottley, Gary

2015-01-01

The importance of social media for marketing professionals has grown immensely as consumers turn to it to connect with products, brands, and brand communities. Yet limited research investigates the uses of social media to teach core marketing concepts. This article analyzes coursework in foundational marketing classes, with a specific focus on the…

Electronic Journalism: More Fear?

ERIC Educational Resources Information Center

Terry, Carolyn

2002-01-01

Considers how the same First Amendment protections that govern print journalism apply to electronic practitioners. Discusses how the number of broadcast and online journalism classes at the nation's high schools demonstrate steady growth, according to a survey conducted in the fall of 2001 for the Radio and Television News Directors Foundation.…

Mendel's Modern Legacy

ERIC Educational Resources Information Center

Dixon, James; Kuldell, Natalie

2012-01-01

Genetic engineering is taught in biology--but as a scientific tool and not as a means to explore engineering design. Yet, given the clever behaviors and patterns that can be found when examining living systems, biology classes seem well positioned to teach foundational engineering design principles (Kuldell 2007). This article examines a new,…

An audit of cavity and crown preparations and two direct restorations carried out by foundation dentists in the Oxford and Wessex Deaneries.

PubMed

Burke, F J T; Mackenzie, L; Falcon, H; Priest, N; Palin, W M

2014-04-01

It is likely that many foundation dentists (FDs) will have completed only minimal amounts of restorative dentistry for a number of months immediately prior to commencing work as FDs. Thus this audit aimed to assess the performance of the FDs when they carried out a number of simulated clinical exercises: amalgam cavities and restoration; Class IV resin composite restorations; and full crown preparations for metal-ceramic restorations. A total of 67 FDs completed the assessments and some results did indicate a high level of concern and need for further evaluation of restorative practice.

Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).

PubMed

Lee, Kuo-Hsiung; Morris-Natschke, Susan; Qian, Keduo; Dong, Yizhou; Yang, Xiaoming; Zhou, Ting; Belding, Eileen; Wu, Shou-Fang; Wada, Koji; Akiyama, Toshiyuki

2012-01-01

This article will review selected herbal products from Chinese Materia Medica that are used in Traditional Chinese Medicine. The herbs come from the upper, middle, and lower class medicines as listed in The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng). The review will focus on the active constituents of the herbs and their bioactivities, with emphasis on the most recent progress in research for the period of 2003 to 2011.

Integration of centrifuge testing in undergraduate geotechnical engineering education at remote campuses

NASA Astrophysics Data System (ADS)

El Shamy, Usama; Abdoun, Tarek; McMartin, Flora; Pando, Miguel A.

2013-06-01

We report the results of a pilot study aimed at developing, implementing, and assessing an educational module that integrates remote major research instrumentation into undergraduate classes. Specifically, this study employs Internet Web-based technologies to allow for real-time video monitoring and execution of cutting-edge experiments. The students' activities within the module are centred on building a model of a shallow foundation on a sand deposit utilising a centrifuge facility and using this model for: (1) visual observation of the response of soil-foundation systems, (2) learning the use of instrumentation, (3) interpretation of acquired data, and (4) comparing experimental results to theoretical predictions. Testing a soil-foundation system helped the students identify the lab experiments needed to analyse and design the system. A survey was used to gauge students' perceptions of learning as a result of introducing the module, which were found to be positive.

Computer Graphic Representation of Remote Environment Using Position Tactile Sensors.

DTIC Science & Technology

1981-08-01

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Growing up and Growing out: Emerging Adults Learn Management through Service-Learning

ERIC Educational Resources Information Center

Fairfield, Kent D.

2010-01-01

This article describes a journey introducing service-learning based on large-scale projects in an undergraduate management curriculum, leading to supplementing this approach with more conventional small-group projects. It outlines some of the foundation for service-learning. Having students undertake a single class-wide project offers distinctive…

Storying Our Claims, Claiming Our Stories: Becoming through Narrative in the Social-Justice Focused Classroom

ERIC Educational Resources Information Center

Kantor, Julia Churchill

2013-01-01

The following project uses both narrative and feminist poststructural lenses to consider how narratives operated in one undergraduate social foundations of education class purposefully designed around issues of social justice. These theoretical frameworks were useful in exploring the ways students and myself, the course instructor, were variously…

Biodiesel and Integrated STEM: Vertical Alignment of High School Biology/Biochemistry and Chemistry

ERIC Educational Resources Information Center

Burrows, Andrea C.; Breiner, Jonathan M.; Keiner, Jennifer; Behm, Chris

2014-01-01

This article explores the vertical alignment of two high school classes, biology and chemistry, around the core concept of biodiesel fuel production. High school teachers and university faculty members investigated biodiesel as it relates to societal impact through a National Science Foundation Research Experience for Teachers. Using an action…

Spaced Retrieval Practice Increases College Students' Short- and Long-Term Retention of Mathematics Knowledge

ERIC Educational Resources Information Center

Hopkins, Robin F.; Lyle, Keith B.; Hieb, Jeff L.; Ralston, Patricia A. S.

2016-01-01

A major challenge college students face is retaining the knowledge they acquire in their classes, especially in cumulative disciplines such as engineering, where ultimate success depends on long-term retention of foundational content. Cognitive psychologists have recently recommended various techniques educators might use to increase retention.…

Best Practices for Learning Physiology: Combining Classroom and Online Methods

ERIC Educational Resources Information Center

Anderson, Lisa C.; Kirchbaum, Kathleen E.

2017-01-01

Physiology is a requisite course for many professional allied health programs and is a foundational science for learning pathophysiology, health assessment, and pharmacology. Given the demand for online learning in the health sciences, it is important to evaluate the efficacy of online and in-class teaching methods, especially as they are combined…

Meandering toward Graduation: Transcript Outcomes of High School Graduates

ERIC Educational Resources Information Center

Bromberg, Marni; Theokas, Christina

2016-01-01

Graduation rates have reached an all-time high and postsecondary enrollment rates are steadily rising in this country. However, thousands of those new college students are testing into remedial reading, writing, or math courses because they don't have the foundation to perform at the levels demanded in college classes. Employers, too, report that…

Orientation, Sketching, Mechanical Drawing, Drafting--Basic: 9253.01.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

The course introduces the student to the drafting trade, freehand sketching, and basic mechanical drawing. The course has no prerequisites and will guide the student into drafting concepts and serve as a foundation for further study in vocational drafting. Requiring a total of 45 class hours, eight hours are utilized in orientation, 15 hours are…

Visualizing Accounting Transaction Flows into Financial Statements

ERIC Educational Resources Information Center

Jones, Daniel J.

2012-01-01

Professors who teach the introductory accounting course should ask themselves: "What are the core concepts that I wish to have my non-majors remember if I meet them at their ten-year alumni class reunion?" There is a fundamental logic to financial accounting. This teaching note presents foundational accounting concepts in a manner that…

Multicultural Children's Literature and Teacher Candidates' Awareness and Attitudes toward Cultural Diversity

ERIC Educational Resources Information Center

Iwai, Yuko

2013-01-01

The purpose of this study was to look at elementary/middle school pre-service teachers' perceptions of multicultural and diversity issues through multicultural children's literature. Nineteen pre-service teachers in a foundation of literacy course explored multicultural children's literature and involved group/class discussions and a project over…

Using Tours Plus "Tutor Tapes" to Teach Humanities in Honolulu's Inner City.

ERIC Educational Resources Information Center

Cox, Clarice Robinson

English 41, an introductory humanities course taught at Honolulu Community College, presented a foundation in art, religion, architecture, and music. Many class members were employed adults, including policemen and firefighters, who often missed off-campus tours and lectures. Tutor tapes were used to offset the problem of absenteeism. A student…

"Intelligence Testing and Minority Students: Foundations, Performance Factors, and Assessment Issues" [book review].

ERIC Educational Resources Information Center

Jensen, Arthur R.

2002-01-01

This book focuses on topics germane to cognitive abilities viewed from a "minority psychology" perspective. The most contentious chapters concern test bias and heredity, with culture, socioeconomic status, and case viewed as the chief explanations for test score differences between social classes and racial and ethnic groups. The reviewer…

Why and How EFL Students Learn Vocabulary in Parliamentary Debate Class

ERIC Educational Resources Information Center

Aclan, Eunice M.; Aziz, Noor Hashima Abdul

2015-01-01

Vocabulary, the backbone of any language including English, is foundational for listening, speaking, reading and writing. These four macro-skills are necessary not only in gaining knowledge as English is the language to access major information sources particularly the World Wide Web but also in the demanding globalized workplace. Vocabulary is…

32 CFR 242.8 - Academic, intellectual, and personal requirements for admission to the first-year class.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the humanities and/or the social and behavioral sciences, for these disciplines complement the study... undertake successfully the study of medicine. (1) Academic requirements. Recognizing that Service medicine... gaining admission to the School, but a strong foundation in the sciences basic to the study of medicine is...

32 CFR 242.8 - Academic, intellectual, and personal requirements for admission to the first-year class.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the humanities and/or the social and behavioral sciences, for these disciplines complement the study... undertake successfully the study of medicine. (1) Academic requirements. Recognizing that Service medicine... gaining admission to the School, but a strong foundation in the sciences basic to the study of medicine is...

Using Business Analysis Software in a Business Intelligence Course

ERIC Educational Resources Information Center

Elizondo, Juan; Parzinger, Monica J.; Welch, Orion J.

2011-01-01

This paper presents an example of a project used in an undergraduate business intelligence class which integrates concepts from statistics, marketing, and information systems disciplines. SAS Enterprise Miner software is used as the foundation for predictive analysis and data mining. The course culminates with a competition and the project is used…

Suggestopedia to SALT and a New Awareness in Education.

ERIC Educational Resources Information Center

Herr, Kay U.

SALT, suggestive-accelerative learning and teaching, is the Americanized version of a pedagogy developed in Bulgaria. While most extensively applied to foreign language teaching, the methodology may be applied to any discipline, particularly one based upon a foundation of learned facts. This document applies the method to ESL classes. The teacher…

Finding a New Path to Learning

ERIC Educational Resources Information Center

Curriculum Review, 2006

2006-01-01

This article presents an interview with Paul Neff, a veteran teacher at Spokane, Washington's Lewis & Clark High. Paul Neff recently earned a $4,930 grant from the Toshiba America Foundation to purchase global-positioning systems and digital cameras for the Outdoor Living class he just took over two years ago. In an interview, Neff talks about…

Cutting Class

ERIC Educational Resources Information Center

Schechtman, Helaine

2011-01-01

During her thirty-five years of teaching, the author has found that starting an introductory course with lessons that almost always guarantee success creates a strong foundation on which the course can be structured. It builds confidence and repairs the damage that may have been done to students who are timid or afraid of failing in their creative…

Intimate Partnership: Foundation to the Successful Balance of Family and Work.

ERIC Educational Resources Information Center

Zimmerman, Toni Schindler; Haddock, Shelley A.; Current, Lisa R.; Ziemba, Scott

2003-01-01

Examines data from interviews with 47 middle-class, dual-earner couples with children, who perceive themselves as successful in balancing family and work. Details how these couples practiced marital partnership in ways that supported effective work-family balance. Data indicates that these successful couples equally share housework and emotion…

Special Education in Korea.

ERIC Educational Resources Information Center

Kim, Byung Ha, Ed.; Yeo, Kwang Eung

The text on special education in Korea is divided into four major sections--a brief history of special education in Korea, the present status of special education in Korea, the special education plan of the Young Kwang Educational Foundation, and directory of schools and classes for the exceptional in Korea. Topics covered include the following:…

Guided Inquiry Activities for Learning about the Macro- and Micronutrients in Introductory Nutrition Courses

ERIC Educational Resources Information Center

Smith, Andri L.; Purcell, Rebecca J.; Vaughan, Joel M.

2015-01-01

Most students enroll in general education introductory nutrition classes because they want to improve their diets in order to lose weight or enhance athletic performance. These nonscience majors are often less interested in learning about the fundamental biochemical principles underlying nutrition or are surprised that this foundational knowledge…

Beginning Inference in Fourth Grade: Exploring Variation in Measurement

ERIC Educational Resources Information Center

English, Lyn; Watson, Jane

2013-01-01

This paper addresses one of the foundational components of beginning interference, namely variation, with 5 classes of Year 4 students undertaking a measurement activity using scaled instruments in two contexts: all students measuring one person's arm span and recording the values obtained, and each student having his/her own arm span measured and…

Girls, Girls, Girls: Gender Composition and Female School Choice

ERIC Educational Resources Information Center

Schneeweis, Nicole; Zweimuller, Martina

2012-01-01

Gender segregation in employment may be explained by women's reluctance to choose technical occupations. However, the foundations for career choices are laid much earlier. Educational experts claim that female students are doing better in math and science and are more likely to choose these subjects if they are in single-sex classes. One possible…

A Teacher's Guide to African Narratives. Studies in African Literature.

ERIC Educational Resources Information Center

O'Brien, Sara Talis

This guide is designed to help secondary school teachers include African literature in their classes. It furnishes English and social studies teachers with a foundation for teaching African literature by offering critical commentary on the texts themselves. A synthesis of anthropological and historical material is presented to help both teachers…

A Reflective Journey through Theory and Research in Mathematical Learning and Development

ERIC Educational Resources Information Center

Belbase, Shashidhar

2010-01-01

This paper is an attempt to reflect on class sessions during the fall 2010 in a course "Theory and Research in Mathematical Learning and Development". This reflection as a learning journey portrays discussions based on foundational perspectives (FP), historical highlights (HH), and guiding questions (GQ) related to mathematics learning and…

Priorities in Vocational Education. Vocational Education Curriculum Specialist, Module 5.

ERIC Educational Resources Information Center

Wheeler, Jeanette D.

One of five modules in the foundation series of the 16-module series designed to train vocational education curriculum specialists, this module is intended for use in classes or individual study arrangements at the preservice or inservice level by students with varying amounts of experience in vocational education. (These modules are revised…

The Scope of Vocational Education. Vocational Education Curriculum Specialist, Module 2.

ERIC Educational Resources Information Center

Wheeler, Jeanette D.

One of five modules in the foundation series of the 16-module series designed to train vocational education curriculum specialists, this module is intended for use in classes or individual study arrangements at the preservice or inservice level by students with varying amounts of experience in vocational education. (These modules are revised…

Ten Traits of Highly Effective Instructors

ERIC Educational Resources Information Center

Lanouette, Mike

2012-01-01

The Bill Gates Foundation has spent as much as a third-world country's income on the following conclusion: one of the primary reasons why students struggle in class and often leave school altogether is instructor ineffectiveness. This may be a slightly painful thing to hear, but, as the saying goes, the truth sometimes hurts. Additionally, the…

A Courageous Look at the American High School

ERIC Educational Resources Information Center

Peterson, Paul E.

2010-01-01

Excellence was seldom to be found in 2006, when David Ferrero, an officer of the Bill and Melinda Gates Foundation, reviewed five firsthand, book-length accounts of teaching and learning at individual high schools. In one account, a rookie teacher, telling her own story, "struggles to establish authority in her classes and generally fails;...her…

2012 College Choice Report--Part 2: Enrollment Patterns

ERIC Educational Resources Information Center

ACT, Inc., 2013

2013-01-01

This report builds on a foundation of knowledge about the academic readiness of the ACT-tested high school graduating class of 2012 as presented in "The Condition of College & Career Readiness" (see ED534761). An important conclusion of the "Condition" report is that far too many high school graduates are not prepared for…

Intercultural Competence among Sports and PE Teachers. Theoretical Foundations and Empirical Verification

ERIC Educational Resources Information Center

Grimminger, Elke

2011-01-01

As intercultural competence among young people is one of the educational missions at European schools, teachers should themselves be able to deal constructively with cultural diversity, as well as encouraging and shaping intercultural learning processes in their classes. This article focuses on the intercultural competence of physical education…

A Qualitative Study: Integrating Art and Science in the Environment

ERIC Educational Resources Information Center

Mills, Deborah N.

2013-01-01

The study was used to develop an understanding of the nature of a creative learning experience that incorporated the foundational elements of Reggio Emilia, place-based education, and experience design. The study took place in an urban high school with eight students in an advanced placement art class. The qualitative research project revolved…

#Class Again? How Education Faculty Engage the Disengaged College Student

ERIC Educational Resources Information Center

Dassa, Lori; Vaughan, Michelle

2018-01-01

Technology should play a role in the classroom, however, the gaps that currently exist between student and teacher use of technology can impede successful technology integration. While teacher education programs and faculty build courses based on foundational pedagogies in the field of curriculum and instruction, current needs, such as technology…

From Theory to Practice: Facing Ethical Challenges as a Clinical Intern

ERIC Educational Resources Information Center

Hambrick, James P.; Pimentel, Sandra; Albano, Anne Marie

2009-01-01

Although formal ethics classes provide a basic foundation in managing ethical dilemmas, professionals often point to their experiences on internship as an important training ground for consolidation of their ethical development. Clinical interns face many personal and professional transitions that can lead to a number of ethical dilemmas.…

Astronaut Hall of Fame

NASA Image and Video Library

2018-04-21

Scott D. Altman, second from left, is inducted into the Astronaut Hall of Fame (AHOF) during a ceremony inside the Space Shuttle Atlantis attraction at NASA's Kennedy Space Center Visitor Complex in Florida. At far left, Hall of Famer Curt Brown, board chairman, Astronaut Scholarship Foundation (ASF), inducts Altman into the Hall of Fame Class of 2018. At right is Hall of Famer John Grunsfeld, who spoke on Altman's behalf during the ceremony. At far right is Thomas D. Jones, Ph.D., who also was inducted into the AHOF Class of 2018. Inductees into the Hall of Fame are selected by a committee of Hall of Fame astronauts, former NASA officials, flight directors, historians and journalists. The process is administered by the Astronaut Scholarship Foundation. To be eligible, an astronaut must have made his or her first flight at least 17 years before the induction. Candidates must be a U.S. citizen and a NASA-trained commander, pilot or mission specialist who has orbited the earth at least once. Including Altman and Jones, 97 astronauts have been inducted into the AHOF.

Theoretical foundations of spatially-variant mathematical morphology part ii: gray-level images.

PubMed

Bouaynaya, Nidhal; Schonfeld, Dan

2008-05-01

In this paper, we develop a spatially-variant (SV) mathematical morphology theory for gray-level signals and images in the Euclidean space. The proposed theory preserves the geometrical concept of the structuring function, which provides the foundation of classical morphology and is essential in signal and image processing applications. We define the basic SV gray-level morphological operators (i.e., SV gray-level erosion, dilation, opening, and closing) and investigate their properties. We demonstrate the ubiquity of SV gray-level morphological systems by deriving a kernel representation for a large class of systems, called V-systems, in terms of the basic SV graylevel morphological operators. A V-system is defined to be a gray-level operator, which is invariant under gray-level (vertical) translations. Particular attention is focused on the class of SV flat gray-level operators. The kernel representation for increasing V-systems is a generalization of Maragos' kernel representation for increasing and translation-invariant function-processing systems. A representation of V-systems in terms of their kernel elements is established for increasing and upper-semi-continuous V-systems. This representation unifies a large class of spatially-variant linear and non-linear systems under the same mathematical framework. Finally, simulation results show the potential power of the general theory of gray-level spatially-variant mathematical morphology in several image analysis and computer vision applications.

Adolescent stalking and risk of violence.

PubMed

Smith-Darden, Joanne P; Reidy, Dennis E; Kernsmith, Poco D

2016-10-01

Stalking perpetration and the associated risk for violence among adolescents has generally been neglected. In the present study, 1236 youth completed surveys assessing empirically established stalking indicators, threats and aggression toward stalking victims, dating violence, and violent delinquency. Latent Profile Analysis identified 3 latent classes of boys: non-perpetrators (NP), hyper-intimate pursuit (HIP), and comprehensive stalking perpetrators (CSP) and, and 2 classes for girls: NP and HIP. Boys in the CSP class were the most violent youth on nearly all indices with boys in the HIP class demonstrating an intermediate level of violence compared to NP boys. Girls in the HIP class were more violent than NP girls on all indices. These findings suggest stalking in adolescence merits attention by violence prevention experts. In particular, juvenile stalking may signify youth at risk for multiple forms of violence perpetrated against multiple types of victims, not just the object of their infatuation. Copyright © 2016 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Structural insights into ligand recognition and selectivity for class A, B, and C GPCRs

PubMed Central

Lee, Sang-Min; Booe, Jason M.; Pioszak, Augen A.

2015-01-01

The G protein-coupled receptor (GPCR) superfamily constitutes the largest collection of cell surface signaling proteins with approximately 800 members in the human genome. GPCRs regulate virtually all aspects of physiology and they are an important class of drug targets with ~30% of drugs on the market targeting a GPCR. Breakthroughs in GPCR structural biology in recent years have significantly expanded our understanding of GPCR structure and function and ushered in a new era of structure-based drug design for GPCRs. Crystal structures for nearly thirty distinct GPCRs are now available including receptors from each of the major classes, A, B, C, and F. These structures provide a foundation for understanding the molecular basis of GPCR pharmacology. Here, we review structural mechanisms of ligand recognition and selectivity of GPCRs with a focus on selected examples from classes A, B, and C, and we highlight major unresolved questions for future structural studies. PMID:25981303

Two new constructions of approximately SIC-POVMs from multiplicative characters

NASA Astrophysics Data System (ADS)

Luo, Gaojun; Cao, Xiwang

2017-12-01

In quantum information theory, symmetric informationally complete positive operator-valued measures (SIC-POVMs) are relevant to quantum state tomography [8], quantum cryptography [15], and foundational studies [16]. In general, it is hard to construct SIC-POVMs and only a few classes of them existed, as we know. Moreover, we do not know whether there exists an infinite class of them. Many researchers tried to construct approximately symmetric informationally complete positive operator-valued measures (ASIC-POVMs). In this paper, we propose two new constructions of ASIC-POVMs for prime power dimensions only by using multiplicative characters over finite fields.

Anxious? Depressed? You might be suffering from capitalism: contradictory class locations and the prevalence of depression and anxiety in the USA.

PubMed

Prins, Seth J; Bates, Lisa M; Keyes, Katherine M; Muntaner, Carles

2015-11-01

Despite a well-established social gradient for many mental disorders, there is evidence that individuals near the middle of the social hierarchy suffer higher rates of depression and anxiety than those at the top or bottom. Although prevailing indicators of socioeconomic status (SES) cannot detect or easily explain such patterns, relational theories of social class, which emphasise political-economic processes and dimensions of power, might. We test whether the relational construct of contradictory class location, which embodies aspects of both ownership and labour, can explain this nonlinear pattern. Data on full-time workers from the National Epidemiologic Survey on Alcohol and Related Conditions (n = 21859) show that occupants of contradictory class locations have higher prevalence and odds of depression and anxiety than occupants of non-contradictory class locations. These findings suggest that the effects of class relations on depression and anxiety extend beyond those of SES, pointing to under-studied mechanisms in social epidemiology, for example, domination and exploitation. © 2015 Foundation for the Sociology of Health & Illness.

Simple webs of natural environment theme as a result of sharing in science teacher training

NASA Astrophysics Data System (ADS)

Tapilouw, M. C.; Firman, H.; Redjeki, S.; Chandra, D. T.

2018-03-01

Thematic learning is one type of integrated science (Biology, Physics, Chemistry and Earth Science) in Science Education. This study is concerning about simple webs of natural environment theme in science learning, as one of training material in science teacher training program. Making simple web is a goal of first step in teacher training program. Every group explain their web illustration to other group. Twenty Junior High School science teacher above one education foundation participate in science teacher training program. In order to gather simple webs, sharing method was used in this first step of science teacher training. The result of this study is five different simple web of natural environment themes. These webs represent science learning in class VII/Semester I, class VII/Semester II, Class VIII, Class IX/Semester I, Class IX/Semester II based on basic competency in National Curriculum 2013. Each group discussed web of natural environment theme based on their learning experience in real class which basic competency and subject matters are linked with natural environment theme. As a conclusion, simple webs are potential to develop in the next step of science teacher training program and to be implemented in real class.

Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon (神農本草經 Shén Nóng Běn Cǎo Jīng)

PubMed Central

Lee, Kuo-Hsiung; Morris-Natschke, Susan; Qian, Keduo; Dong, Yizhou; Yang, Xiaoming; Zhou, Ting; Belding, Eileen; Wu, Shou-Fang; Wada, Koji; Akiyama, Toshiyuki

2012-01-01

This article will review selected herbal products from Chinese Materia Medica that are used in Traditional Chinese Medicine. The herbs come from the upper, middle, and lower class medicines as listed in The Divine Husbandman's Herbal Foundation Canon (神農本草經 Shén Nóng Běn Cǎo Jīng). The review will focus on the active constituents of the herbs and their bioactivities, with emphasis on the most recent progress in research for the period of 2003 to 2011. PMID:24716110

Expanding the Scope of Advanced Placement Classes

ERIC Educational Resources Information Center

Lim, Victoria

2008-01-01

Dr. Paul Dosal of the University of South Florida is not impressed with the way most high school students learn about Latin American history. Dosal believes an advanced placement course in the subject will change that. He's the executive director of ENLACE Florida, a statewide network funded by the W.K. Kellogg Foundation, designed to increase the…

Do Facilitated Online Dual Credit Classes Result in Deep Learning?

ERIC Educational Resources Information Center

Stark Education Partnership, 2015

2015-01-01

This study, with funding from the Jennings Foundation, sought to answer the following broad research question: Do facilitated online dual credit courses result in deep learning? The answer to this question is key to addressing barriers many students face in bridging from high school to college. This report includes a descriptive case study that…

Scaffolding for Mathematics Teaching in Inclusive Primary Classrooms: A Video Study

ERIC Educational Resources Information Center

Pfister, Mirjam; Moser Opitz, Elisabeth; Pauli, Christine

2015-01-01

Scaffolding is an important tool for meeting the challenging needs of heterogeneous groups of students in inclusive classrooms. It is especially useful when supporting low achievers. A video study (funded by the Swiss National Science Foundation, Project Nr. 134652) of 36 inclusive classes, (3rd grade, aged 9 years), was conducted to examine how…

NASA Instrument Cost Model for Explorer-Like Mission Instruments (NICM-E)

NASA Technical Reports Server (NTRS)

Habib-Agahi, Hamid; Fox, George; Mrozinski, Joe; Ball, Gary

2013-01-01

NICM-E is a cost estimating relationship that supplements the traditional NICM System Level CERs for instruments flown on NASA Explorer-like missions that have the following three characteristics: 1) fly on Class C missions, 2) major development led and performed by universities or research foundations, and 3) have significant level of inheritance.

Maximize Your Teaching

ERIC Educational Resources Information Center

Cleaver, Samantha

2011-01-01

Here's an awesome thought! Teaching means a teacher's impact on students will last a lifetime. And despite the negatives one hears in the news, a 2010 ING Foundation poll found that 98 percent of adults believe a good teacher can "change the course of a child's life." This year, a teacher will affect every child in his/her class. Over the course…

Voicing the E in WOVE: Improving Reflection in ISUComm Foundation Courses ePortfolios

ERIC Educational Resources Information Center

Blakely, Barbara J.

2016-01-01

Using the literatures of student personal epistemology and approaches to learning, this article describes one WPA's deliberate pursuit of a deep approach to her learning about reflection. Other WPAs and instructors who have encountered an unexpected gap in their programs' or classes' work with reflection can revise documents and re-tune pedagogy…

Lift Every Voice and Sing: Democratic Dialogue in a Teacher Education Classroom.

ERIC Educational Resources Information Center

Hufford, Don

This paper describes a model that builds on the assumption that educators teaching foundations of education courses have a unique opportunity to model the democratic process and a moral responsibility to infuse the art of human conversation and self-transcendence into education. Exposure to such classes may encourage preservice teachers to go…

Impact of scale on morphological spatial pattern of forest

Treesearch

Katarzyna Ostapowicz; Peter Vogt; Kurt H. Riitters; Jacek Kozak; Christine Estreguil

2008-01-01

Assessing and monitoring landscape pattern structure from multi-scale land-cover maps can utilize morphological spatial pattern analysis (MSPA), only if various influences of scale are known and taken into account. This paper lays part of the foundation for applying MSPA analysis in landscape monitoring by quantifying scale effects on six classes of spatial patterns...

Sorting: Groups and Graphs. Used Numbers. Grades 2-3.

ERIC Educational Resources Information Center

Russell, Susan Jo; Corwin, Rebecca B.

A unit of study that introduces sorting and classification as a way of organizing data is presented. Suitable for students in grades 2 and 3, it provides a foundation for further work in statistics and data analysis. The investigations may extend from one to five class sessions and are grouped into three parts: "Introduction to Sorting"; "Sorting…

Using Desktop Publishing in an Editing Class--The Lessons Learned and Students' Assessments.

ERIC Educational Resources Information Center

Tharp, Marty; Zimmerman, Don

1992-01-01

Reports students' perceptions of learning desktop publishing (DTP) systems. Finds that (1) students learned the foundations of DTP in under 60 hours of hands-on experience; (2) the incremental introduction of DTP functions and practice sessions before assignments were the most effective teaching strategy; and (3) use of DTP encouraged nonartistic…

Militarizing Class Warfare: The Historical Foundations of the Neoliberal/ Neoconservative Nexus

ERIC Educational Resources Information Center

Gabbard, David

2007-01-01

Given the vacuity of political metaphors in the USA, most Americans might assume neoliberalism and neoconservatism to be at odds with one another. This article argues to the contrary. Neoconservatism has provided a solution to a crisis in neoliberalism--the crisis of how to manufacture the public's support for an agenda that was so decidedly…

Maximize a Team-Based Learning Gallery Walk Experience: Herding Cats Is Easier than You Think

ERIC Educational Resources Information Center

Rodenbaugh, David W.

2015-01-01

Team-based learning (TBL) is an instructional strategy that promotes small group learning and peer instruction in a large class environment. TBL is structured to include the following steps: 1) student preparation, e.g., reading/reviewing course lectures, and 2) readiness assurance testing. Preparation and foundational knowledge is assessed on an…

Integrating True Short Stories into English Classes: The Case of Foundation Students in Oman

ERIC Educational Resources Information Center

Al Siyabi, Munira Said

2017-01-01

Searching for practical ways to improve students' English language skills is a real concern for all English teachers. There is a consensus among ELT practitioners regarding the significance of reading for learning new languages, since reading gives depth to language learning (Stern, 2001). Thus, teachers are obligated to provide their students…

Graphic Novels: An Alternative Approach to Teach English as a Foreign Language

ERIC Educational Resources Information Center

Öz, Hüseyin; Efecioglu, Emine

2015-01-01

This article reports the findings of a study that investigated the role of graphic novels in teaching English as a foreign language (EFL) to International Baccalaureate students (aged 15-16) in TED Ankara College Foundation Private High School. Two intact 10th grade classes were randomly assigned to the control and experimental groups who studied…

Looking Forward: Games, Rhymes and Exercises To Help Children Develop Their Learning Abilities.

ERIC Educational Resources Information Center

von Heider, Molly

The range of games, rhymes, songs, and exercises for children collected in this book are based on Rudolf Steiner's educational philosophy and are designed to lay the foundation for sound later learning. The book's chapters are: (1) "Learning Aids"; (2) "The Early Years"; (3) "Foot Exercises: Kindergarten or Class I, 5-7…

In a Class with Klein: Generating a Model of the Hyperbolic Plane

ERIC Educational Resources Information Center

Otten, Samuel; Zin, Christopher

2012-01-01

The emergence of non-Euclidean geometries in the 19th century rocked the foundations of mathematical knowledge and certainty. The tremors can still be felt in undergraduate mathematics today where encounters with non-Euclidean geometry are novel and often shocking to students. Because of its divergence from ordinary and comfortable notions of…

America's Pressing Challenge - Building a Stronger Foundation. A Companion to Science and Engineering Indicators - 2006. NSB-06-02

ERIC Educational Resources Information Center

National Science Foundation, 2006

2006-01-01

This document identifies priorities for ensuring a world-class education in science, technology, engineering, and mathematics (STEM) fields for all Americans. America's competitive edge in this "flat world," its strength and versatility, all depend on an educational system capable of producing young people and productive citizens who are well…

Theatrical Style: A Visual Approach to the Theatre.

ERIC Educational Resources Information Center

Russell, Douglas A.

This book provides students and teachers of scenic design and drama classes with a foundation for planning the style of a theater production. Each chapter in the book discusses the art and culture of a major period in the history of the theater, the developments in theater and in dramatic method that took place, and at least one play…

Gorilla Creativity: A Study Unit To Promote Critical and Creative Thinking.

ERIC Educational Resources Information Center

Allen, Cindi Nolen

This book provides student activities organized around a class science project with the Gorilla Foundation. The gorillas featured in the project have been taught American Sign Language. Many of the activities involve the use of the story "Koko's Kitten" by Francine Patterson (New York: Scholastic, Inc., 1985). Sections of the book include: (1) "To…

BOREAS RSS-20 POLDER Radiance Images From the NASA C-130

NASA Technical Reports Server (NTRS)

Leroy, M.; Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Smith, David E. (Technical Monitor)

2000-01-01

These Boreal Ecosystem-Atmosphere Study (BOREAS) Remote Sensing Science (RSS)-20 data are a subset of images collected by the Polarization and Directionality of Earth's Reflectance (POLDER) instrument over tower sites in the BOREAS study areas during the intensive field campaigns (IFCs) in 1994. The POLDER images presented here from the NASA ARC C-130 aircraft are made available for illustration purposes only. The data are stored in binary image-format files. The POLDER radiance images are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

Single-Cell mRNA-Seq Using the Fluidigm C1 System and Integrated Fluidics Circuits.

PubMed

Gong, Haibiao; Do, Devin; Ramakrishnan, Ramesh

2018-01-01

Single-cell mRNA-seq is a valuable tool to dissect expression profiles and to understand the regulatory network of genes. Microfluidics is well suited for single-cell analysis owing both to the small volume of the reaction chambers and easiness of automation. Here we describe the workflow of single-cell mRNA-seq using C1 IFC, which can isolate and process up to 96 cells. Both on-chip procedure (lysis, reverse transcription, and preamplification PCR) and off-chip sequencing library preparation protocols are described. The workflow generates full-length mRNA information, which is more valuable compared to 3' end counting method for many applications.

BOREAS RSS-7 Regional LAI and FPAR Images From 10-Day AVHRR-LAC Composites

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Chen, Jing; Cihlar, Josef

2000-01-01

The BOReal Ecosystem-Atmosphere Study Remote Sensing Science (BOREAS RSS-7) team collected various data sets to develop and validate an algorithm to allow the retrieval of the spatial distribution of Leaf Area Index (LAI) from remotely sensed images. Advanced Very High Resolution Radiometer (AVHRR) level-4c 10-day composite Normalized Difference Vegetation Index (NDVI) images produced at CCRS were used to produce images of LAI and the Fraction of Photosynthetically Active Radiation (FPAR) absorbed by plant canopies for the three summer IFCs in 1994 across the BOREAS region. The algorithms were developed based on ground measurements and Landsat Thematic Mapper (TM) images. The data are stored in binary image format files.

Department of the Navy Justification of Estimates for Fiscal Year 1985 Submitted to Congress February 1984. Operation & Maintenance, Navy. Book 1. Budget Activity 1. Strategic Forces Budget. Activity 2. General Purpose Forces. Budget Activity 4. Airlift and Sealift.

DTIC Science & Technology

1984-02-01

8217•;.•;-;•;.•-;.••-.-.• • >;.--;.-:.--V. ^yv\\.-.-;. ^^j^dE&S^&Sfl&ifc^^ •• ’,•. qiv.’ .VA" wie K*\\m WQ v?*-’.^v’:.w’’Ay-7«’?𔄁-’J> TV* •’•’• "-’ •I»l ••. " ’. • V 1 :"V...costs associated with leasing stores ships (TAFS) which provide dry cargo resupply for ships on station in operating areas, oilers ( TAOs ) which

Verification and Validation of Adaptive and Intelligent Systems with Flight Test Results

NASA Technical Reports Server (NTRS)

Burken, John J.; Larson, Richard R.

2009-01-01

F-15 IFCS project goals are: a) Demonstrate Control Approaches that can Efficiently Optimize Aircraft Performance in both Normal and Failure Conditions [A] & [B] failures. b) Advance Neural Network-Based Flight Control Technology for New Aerospace Systems Designs with a Pilot in the Loop. Gen II objectives include; a) Implement and Fly a Direct Adaptive Neural Network Based Flight Controller; b) Demonstrate the Ability of the System to Adapt to Simulated System Failures: 1) Suppress Transients Associated with Failure; 2) Re-Establish Sufficient Control and Handling of Vehicle for Safe Recovery. c) Provide Flight Experience for Development of Verification and Validation Processes for Flight Critical Neural Network Software.

Some factors associated with change in patient-centredness of student nurses during the Common Foundation Programme in Nursing.

PubMed

Rolfe, G

1994-10-01

This longitudinal study examines the changes in patient-centredness of a group of student nurses during their Common Foundation Programme in Nursing, and attempts to explore some of the social, psychological and educational factors which might be associated with such change. The Patient-centredness Multi-choice Questionnaire (PMQX) was administered to a sample of 267 student nurses on commencement and completion of their Common Foundation Programme in Nursing, and significant positive as well as negative changes in PMQX scores were found, although the mean scores for the sample were unchanged. A number of factors were found to be associated with high levels of patient-centredness on commencement of the course, including marital status, age, and radicalism. Positive change in patient-centredness during the CFP was associated with a variety of variables such as class size, a student-centred climate and a tenderminded attitude. Other factors, such as psychological stability and extroversion, were associated with both increase and decrease in patient-centredness during the CFP.

WNCC Observatory

NASA Astrophysics Data System (ADS)

Snyder, L. F.

2003-05-01

Western Nevada Community College (WNCC), located in Carson City, Nevada, is a small two year college with only 6,000 students. Associate degrees and Cer- tificates of Achievement are awarded. The college was built and started classes in 1971 and about 12 years ago the chair of the physics department along with a few in administration had dreams of building a small observatory for education. Around that time a local foundation, Nevada Gaming Foundation for Education Excellence, was looking for a beneficiary in the education field to receive a grant. They decided an observatory at the college met their criteria. Grants to the foundation instigated by Senators, businesses, and Casinos and donations from the local public now total $1.3 million. This paper will explain the different facets of building the observatory, the planning, construction, telescopes and equipment decisions and how we think it will operate for the public, education and research. The organization of local volunteers to operate and maintain the observatory and the planned re- search will be explained.

Developing an Undergraduate Public Health Introductory Core Course Series

PubMed Central

Nelson-Hurwitz, Denise C.; Tagorda, Michelle; Kehl, Lisa; Buchthal, Opal V.; Braun, Kathryn L.

2018-01-01

The number of undergraduate public health education programs is increasing, but few publications provide examples of introductory public health courses that provide foundational knowledge and meet 2016 Council on Education in Public Health (CEPH) accreditation standards. This article presents the development and testing of a three-course, introductory series in public health at the University of Hawai‘i at Mānoa (UHM). Development was informed by best pedagogical practices in education, web review of existing programs, literature review, key informant interviews, and accreditation standards. Student mastery of required concepts, domains, and competencies is assessed through testing and class assignments. Data from course evaluations, students' exit questionnaires at graduation, and faculty feedback were used to continuously evolve and adapt the curriculum. The three-course series—including Introduction to Public Health, Public Health Issues in Hawai‘i, and Introduction to Global Health—was designed to provide incoming undergraduate public health students with a foundation in local, national, and global public health concepts and domains, while improving their skills in public health communication and information literacy. Data from class assignments, examinations, and later coursework suggest students are mastering the course materials and gaining required competencies. Data from course evaluation and exit questionnaires suggest that the students appreciate the series' approach and the challenge to apply course concepts locally and globally in subsequent courses. This foundational public health series provides a model for an introductory course series that can be implemented with existing resources by most programs, meets the new CEPH requirements, is well-received by students, and prepares students well for upper-division public health courses. PMID:29892596

Better learning through instructional science: a health literacy case study in "how to teach so learners can learn".

PubMed

Freedman, Ariela M; Echt, Katharina V; Cooper, Hannah L F; Miner, Kathleen R; Parker, Ruth

2012-09-01

Health education and behavior change interventions typically pay little attention to the intervention's instructional foundation. Combining the fields of health literacy, cognitive psychology, and adult learning theory, this article provides an integrative scientific approach, called the BEAN (Better Education and iNnovation) model, to creating an instructional foundation based on how individuals acquire knowledge and skills. The article uses a case study example from an adult literacy center's health literacy class to explore how environmental factors and instructional strategies can be applied to health education and behavior change interventions. Data for this case study were derived through 20 hours of classroom observation and qualitative interviews with 21 adult education students and 3 instructors. Results provide practical examples of environmental factors and instructional strategies designed to facilitate learning, such as fostering autonomy, activating prior knowledge, and fostering perspective change. Results also describe the resulting health behavior changes of students attending the health literacy class, such as increased medication adherence and physical activity, improved nutritional habits, and increased question asking of health practitioners. This article serves as a first step to encouraging researchers and educators to consider the importance of drawing on cognitive psychology and theories of adult learning to create a scientifically based instructional foundation for health behavior change programs. Additionally, by drawing on the expertise of adult educators well versed in the science of instructional design, this article also demonstrates that the adult education classroom is an excellent setting for conducting health education and behavior change interventions.

Developing an Undergraduate Public Health Introductory Core Course Series.

PubMed

Nelson-Hurwitz, Denise C; Tagorda, Michelle; Kehl, Lisa; Buchthal, Opal V; Braun, Kathryn L

2018-01-01

The number of undergraduate public health education programs is increasing, but few publications provide examples of introductory public health courses that provide foundational knowledge and meet 2016 Council on Education in Public Health (CEPH) accreditation standards. This article presents the development and testing of a three-course, introductory series in public health at the University of Hawai'i at Mānoa (UHM). Development was informed by best pedagogical practices in education, web review of existing programs, literature review, key informant interviews, and accreditation standards. Student mastery of required concepts, domains, and competencies is assessed through testing and class assignments. Data from course evaluations, students' exit questionnaires at graduation, and faculty feedback were used to continuously evolve and adapt the curriculum. The three-course series-including Introduction to Public Health, Public Health Issues in Hawai'i, and Introduction to Global Health-was designed to provide incoming undergraduate public health students with a foundation in local, national, and global public health concepts and domains, while improving their skills in public health communication and information literacy. Data from class assignments, examinations, and later coursework suggest students are mastering the course materials and gaining required competencies. Data from course evaluation and exit questionnaires suggest that the students appreciate the series' approach and the challenge to apply course concepts locally and globally in subsequent courses. This foundational public health series provides a model for an introductory course series that can be implemented with existing resources by most programs, meets the new CEPH requirements, is well-received by students, and prepares students well for upper-division public health courses.

Unpacking the lunchbox: biopedagogies, mothering and social class.

PubMed

Cappellini, Benedetta; Harman, Vicki; Parsons, Elizabeth

2018-06-19

This study investigates how mothers respond to school surveillance of their children's packed lunches. In a context where increasing attention is focused on healthy eating, we adopt a biopedagogical approach to illustrate different positions and strategies which mothers occupy in relation to feeding their children in the school setting. We use photo-elicitation interviews and focus groups to trace both the discursive and practical significance of these biopedagogies. We find that the subjective experiences of feeding children at school are infused with classed notions of mothering in public. Our analysis highlights two broad positions. Firstly, there were those with strong distinctions between home-food and school-food, which was associated more clearly with middle class families. Secondly, there were those with more fluid boundaries between home-food and school-food. This was more commonly encapsulated by working class mothers who were seen to place more emphasis on their children as autonomous decision-makers. Overall the findings document localised and classed practices of resisting the school's normalising gaze. © 2018 Foundation for the Sociology of Health & Illness.

Grafting: Making Space for International and Comparative Education in a Pre-Service Teacher Social Foundations Class

ERIC Educational Resources Information Center

Shah, Payal; Brown, Kara D.

2016-01-01

This article contributes to a growing appreciation and understanding of both the ways to include exposure to Comparative and International Education (CIE) in undergraduate teacher education as well as to how students take up and respond creatively to opportunities for comparative exploration. In order to make space for comparative education in the…

The Shuttering of Educational Studies: Neoliberalism, the Political Spectacle, and Social Injustice at a "World Class" University

ERIC Educational Resources Information Center

Dunn, Alyssa Hadley; Faison, Morgan Zacheya-Jewel

2015-01-01

This article examines the September 2012 closure of the Division of Educational Studies (DES) at Emory University. The authors present this discussion as an example of the ways that the neoliberalization of higher education contributes to the extinction of educational foundations programs. What happened at Emory is symptomatic of the impact that…

Bridging Class and Field: Field Instructors' and Liaisons' Reactions to Information about Students' Baseline Performance Derived from Simulated Interviews

ERIC Educational Resources Information Center

Bogo, Marion; Lee, Barbara; McKee, Eileen; Ramjattan, Roxanne; Baird, Stephanie L.

2017-01-01

To strengthen students' preparation for engaging in field learning, an innovation was implemented to teach and assess foundation-year students' performance prior to entering field education. An Objective Structured Clinical Examination informed the final evaluation of students' performance in two companion courses on practice theory and skills.…

Teaching Students How to Study: A Workshop on Information Processing and Self-Testing Helps Students Learn

ERIC Educational Resources Information Center

Stanger-Hall, Kathrin F.; Shockley, Floyd W.; Wilson, Rachel E.

2011-01-01

We implemented a "how to study" workshop for small groups of students (6-12) for N = 93 consenting students, randomly assigned from a large introductory biology class. The goal of this workshop was to teach students self-regulating techniques with visualization-based exercises as a foundation for learning and critical thinking in two areas:…

Year-Long Peer Mentoring Activity to Enhance the Retention of Freshmen STEM Students in a NSF Scholarship Program

ERIC Educational Resources Information Center

Cutright, Teresa J.; Evans, Edward

2016-01-01

The last year of a National Science Foundation (NSF) funded scholarship program was used to provide pseudo-formal peer mentoring activities to engineering, mathematics, and science undergraduates. A one-credit class was used to afford time for peer mentors and mentees to interact. During the fall semester, seniors augmented each week's topics with…

A Conceptual Framework for Educational Design at Modular Level to Promote Transfer of Learning

ERIC Educational Resources Information Center

Botma, Yvonne; Van Rensburg, G. H.; Coetzee, I. M.; Heyns, T.

2015-01-01

Students bridge the theory-practice gap when they apply in practice what they have learned in class. A conceptual framework was developed that can serve as foundation to design for learning transfer at modular level. The framework is based on an adopted and adapted systemic model of transfer of learning, existing learning theories, constructive…

A Quantitative Assessment of an Application of Halpern's Teaching for Critical Thinking in a Business Class

ERIC Educational Resources Information Center

Reid, Joanne R.

2010-01-01

Can Critical Thinking be taught and learned? The author used a pre-experimental research method to answer this question. The foundation of this research study was Halpern's Teaching for Critical Thinking model. The instructional design paradigm was the 2003 Cognitive Training Model of Foshay, Silber, and Stelnicki. The author developed a course…

Leveraging Cognitive Load Theory, Scaffolding, and Distance Technologies to Enhance Computer Programming for Non-Majors

ERIC Educational Resources Information Center

Impelluso, Thomas J.

2009-01-01

Cognitive Load Theory (CLT) was used as a foundation to redesign a computer programming class for mechanical engineers, in which content was delivered with hybrid/distance technology. The effort confirmed the utility of CLT in course design. And it demonstrates that hybrid/distance learning is not merely a tool of convenience, but one, which, when…

Measuring: From Paces to Feet. Used Numbers: Real Data in the Classroom. Grades 3-4.

ERIC Educational Resources Information Center

Corwin, Rebecca B.; Russell, Susan Jo

A unit of study that introduces measuring as a way of collecting data is presented. Suitable for students in grades 3 and 4, it provides a foundation for further work in statistics and data analysis. The investigations may extend from one to four class sessions and are grouped into three parts: "Introduction to Measurement"; "Using Standard…

Statistics: The Shape of the Data. Used Numbers: Real Data in the Classroom. Grades 4-6.

ERIC Educational Resources Information Center

Russell, Susan Jo; Corwin, Rebecca B.

A unit of study that introduces collecting, representing, describing, and interpreting data is presented. Suitable for students in grades 4 through 6, it provides a foundation for further work in statistics and data analysis. The investigations may extend from one to four class sessions and are grouped into three parts: "Introduction to Data…

Evaluating the Impact of Remedial Education in Florida Community Colleges: A Quasi-Experimental Regression Discontinuity Design. NCPR Brief

ERIC Educational Resources Information Center

Calcagno, Juan Carlos; Long, Bridget Terry

2009-01-01

The conceptual foundation for remedial education is straightforward: students are tested to determine whether they meet a given level of academic proficiency for college-level classes. For those who do not meet this level, deficiencies in skills are addressed through some form of supplementary instruction, most often remedial courses. The study…

Following Through: Representing the Voice of Graduate Students

ERIC Educational Resources Information Center

Amankwatia, Tonya; Barbour, Michael; Inan, Fethi A.; Parker, Preston; Slagter van Tryon, Patricia J.

2007-01-01

The 2006 Class of AECT Interns has from the outset been uniquely involved and proactive in supporting the goals of the ect Foundation and of AECT. This article further illustrates the good work this group is doing to support their mutual mission and goals. In the March/April 2007 issue of "Tech Trends," the authors outlined their plans for the…

Teaching Feminist Theory via Philosophy: Political Implications of an Ontological Inquiry in Judith Butler's "Gender Trouble."

ERIC Educational Resources Information Center

Artese, Brian

Rather than begin an undergraduate class in feminist theory with the assertion that such theory is important because of its social implications--and then attempt to prove it--it is more effective to begin with a more neutral philosophical discussion that will act as a foundation for its premises. Judith Butler's essay "Gender Trouble"…

The Early College High School Initiative: An Overview of Five Evaluation Years

ERIC Educational Resources Information Center

Berger, Andrea; Adelman, Nancy; Cole, Susan

2010-01-01

In 2002, the Bill & Melinda Gates Foundation started the Early College High School Initiative (ECHSI). Through this initiative, more than 200 Early College Schools (ECSs) opened by fall 2009. All of the schools aim to provide underserved students access to college classes while in high school. This article will provide an overview of the first 6…

Introduction: Strengthening the foundation of wildland fire Effects prediction for research and management

Treesearch

Matthew B. Dickinson; Kevin C. Ryan

2010-01-01

As prescribed fire use increases and the options for responding to wildfires continue to expand beyond suppression, the need for improving fire effects prediction capabilities be¬comes increasingly apparent. The papers in this Fire Ecology special issue describe recent advances in fire effects prediction for key classes of direct (first-order) fire effects. Important...

Gender Differences in the Effects of a Utility-Value Intervention to Help Parents Motivate Adolescents in Mathematics and Science

ERIC Educational Resources Information Center

Rozek, Christopher S.; Hyde, Janet S.; Svoboda, Ryan C.; Hulleman, Chris S.; Harackiewicz, Judith M.

2015-01-01

A foundation in science, technology, engineering, and mathematics (STEM) education is critical for students' college and career advancement, but many U.S. students fail to take advanced mathematics and science classes in high school. Research has neglected the potential role of parents in enhancing students' motivation for pursuing STEM courses.…

An Innovative Teaching Strategy: Using Critical Thinking To Give Students a Guide to the Future.

ERIC Educational Resources Information Center

Oliver, Helen; Utermohlen, Robert

College students in a Foundations of Education class at Rust College (Mississippi), a small historically black liberal arts college, were required in 1993 and again in 1994 to develop a modified personal strategic plan using critical thinking skills. The plan had four components: a family history; a present situation; a strengths, weaknesses,…

London Challenge: Surveys of Pupils and Teachers, 2005. Research Report RR718

ERIC Educational Resources Information Center

Ridley, Kate; Knight, Sarah; Scott, Emma; Benton, Tom; Woodthorpe, Adrian

2006-01-01

The London Challenge is a Department for Education and Skills (DfES) initiative, which aims to raise levels of attainment in London secondary schools and to create a world class education system in the capital. In 2005, London Challenge commissioned the National Foundation for Educational Research (NFER) to carry out a survey of Year 7 pupils,…

Delivering Science to Large Audiences: Experiments in Active Learning and Public Lectures at the University of Michigan

NASA Astrophysics Data System (ADS)

McKay, T.

1999-12-01

The problem of disseminating scientific knowledge to the broader community in an effective and efficient way is always with us. At the University of Michigan we have been addressing this problem in several ways. Every year we teach introductory physics to about 3000 students. We believe that, in addition to a pedagogical responsibility, this is an important opportunity for outreach. We report on a variety of approaches to active learning in large lecture classes which are aimed at aiding student comprehension of conceptual material. These have the side affect of improving their general impression of science. In addition to the traditional classroom, we have also engaged in a broader outreach program through the Saturday Morning Physics lecture series, which through a combination of programming and advertising draws audiences of 250 a week to 15 weeks of lectures on topics of current research. We conclude with some general observations about the relation between the success of these public lectures and our large lecture classes. This work is supported by a CAREER award from the National Science Foundation, the University of Michigan, and the Ted Annis Foundation.

Describing three-class task performance: three-class linear discriminant analysis and three-class ROC analysis

NASA Astrophysics Data System (ADS)

He, Xin; Frey, Eric C.

2007-03-01

Binary ROC analysis has solid decision-theoretic foundations and a close relationship to linear discriminant analysis (LDA). In particular, for the case of Gaussian equal covariance input data, the area under the ROC curve (AUC) value has a direct relationship to the Hotelling trace. Many attempts have been made to extend binary classification methods to multi-class. For example, Fukunaga extended binary LDA to obtain multi-class LDA, which uses the multi-class Hotelling trace as a figure-of-merit, and we have previously developed a three-class ROC analysis method. This work explores the relationship between conventional multi-class LDA and three-class ROC analysis. First, we developed a linear observer, the three-class Hotelling observer (3-HO). For Gaussian equal covariance data, the 3- HO provides equivalent performance to the three-class ideal observer and, under less strict conditions, maximizes the signal to noise ratio for classification of all pairs of the three classes simultaneously. The 3-HO templates are not the eigenvectors obtained from multi-class LDA. Second, we show that the three-class Hotelling trace, which is the figureof- merit in the conventional three-class extension of LDA, has significant limitations. Third, we demonstrate that, under certain conditions, there is a linear relationship between the eigenvectors obtained from multi-class LDA and 3-HO templates. We conclude that the 3-HO based on decision theory has advantages both in its decision theoretic background and in the usefulness of its figure-of-merit. Additionally, there exists the possibility of interpreting the two linear features extracted by the conventional extension of LDA from a decision theoretic point of view.

[A cloud detection algorithm for MODIS images combining Kmeans clustering and multi-spectral threshold method].

PubMed

Wang, Wei; Song, Wei-Guo; Liu, Shi-Xing; Zhang, Yong-Ming; Zheng, Hong-Yang; Tian, Wei

2011-04-01

An improved method for detecting cloud combining Kmeans clustering and the multi-spectral threshold approach is described. On the basis of landmark spectrum analysis, MODIS data is categorized into two major types initially by Kmeans method. The first class includes clouds, smoke and snow, and the second class includes vegetation, water and land. Then a multi-spectral threshold detection is applied to eliminate interference such as smoke and snow for the first class. The method is tested with MODIS data at different time under different underlying surface conditions. By visual method to test the performance of the algorithm, it was found that the algorithm can effectively detect smaller area of cloud pixels and exclude the interference of underlying surface, which provides a good foundation for the next fire detection approach.

Distinct effects of childhood ADHD and cannabis use on brain functional architecture in young adults.

PubMed

Kelly, Clare; Castellanos, F Xavier; Tomaselli, Olivia; Lisdahl, Krista; Tamm, Leanne; Jernigan, Terry; Newman, Erik; Epstein, Jeffery N; Molina, Brooke S G; Greenhill, Laurence L; Potkin, Steven G; Hinshaw, Stephen; Swanson, James M

2017-01-01

One of the most salient long-term implications of a childhood diagnosis of ADHD is an increased risk for substance use, abuse, or dependence in adolescence and adulthood. The extent to which cannabis use affects ADHD-related alterations in brain functional organization is unknown, however. To address this research gap, we recruited a sample of 75 individuals aged 21-25 years with and without a childhood diagnosis of ADHD Combined Type, who were either frequent users or non-users of cannabis. These participants have been followed longitudinally since age 7-9.9 years as part of a large multi-site longitudinal study of ADHD, the Multimodal Treatment Study of Children with ADHD (MTA). We examined task-independent intrinsic functional connectivity (iFC) within 9 functional networks using a 2 × 2 design, which compared four groups of participants: (1) individuals with a childhood diagnosis of ADHD who currently use cannabis ( n  = 23); (2) individuals with ADHD who do not currently use cannabis ( n  = 22); (3) comparisons who currently use cannabis ( n  = 15); and (4) comparisons who do not currently use cannabis ( n  = 15). The main effects of childhood ADHD were primarily weakened iFC in networks supporting executive function and somatomotor control. Contrary to expectations, effects of cannabis use were distinct from those of diagnostic group and no interactions were observed. Exploratory brain-behavior analyses suggested that ADHD-related effects were primarily linked with poorer neurocognitive performance. Deficits in the integrity of functional networks supporting executive function and somatomotor control are consistent with the phenotypic and neurocognitive features of ADHD. Our data suggest that cannabis use does not exacerbate ADHD-related alterations, but this finding awaits replication in a larger sample. Longitudinal neuroimaging studies are urgently required to delineate the neurodevelopmental cascade that culminates in positive and negative outcomes for those diagnosed with ADHD in childhood.

Impaired insight into illness and cognitive insight in schizophrenia spectrum disorders: Resting state functional connectivity

PubMed Central

Gerretsen, Philip; Menon, Mahesh; Mamo, David C.; Fervaha, Gagan; Remington, Gary; Pollock, Bruce G.; Graff-Guerrero, Ariel

2015-01-01

Background Impaired insight into illness (clinical insight) in schizophrenia has negative effects on treatment adherence and clinical outcomes. Schizophrenia is described as a disorder of disrupted brain connectivity. In line with this concept, resting state networks (RSNs) appear differentially affected in persons with schizophrenia. Therefore, impaired clinical, or the related construct of cognitive insight (which posits that impaired clinical insight is a function of metacognitive deficits), may reflect alterations in RSN functional connectivity (fc). Based on our previous research, which showed that impaired insight into illness was associated with increased left hemisphere volume relative to right, we hypothesized that impaired clinical insight would be associated with increased connectivity in the DMN with specific left hemisphere brain regions. Methods Resting state MRI scans were acquired for participants with schizophrenia or schizoaffective disorder (n = 20). Seed-to-voxel and ROI-to-ROI fc analyses were performed using the CONN-fMRI fc toolbox v13 for established RSNs. Clinical and cognitive insight were measured with the Schedule for the Assessment of Insight—Expanded Version and Beck Cognitive Insight Scale, respectively, and included as the regressors in fc analyses. Results As hypothesized, impaired clinical insight was associated with increased connectivity in the default mode network (DMN) with the left angular gyrus, and also in the self-referential network (SRN) with the left insula. Cognitive insight was associated with increased connectivity in the dorsal attention network (DAN) with the right inferior frontal cortex (IFC) and left anterior cingulate cortex (ACC). Conclusion Increased connectivity in DMN and SRN with the left angular gyrus and insula, respectively, may represent neural correlates of impaired clinical insight in schizophrenia spectrum disorders, and is consistent with the literature attributing impaired insight to left hemisphere dominance. Increased connectivity in the DAN with the IFC and ACC in relation to cognitive insight may facilitate enhanced mental flexibility in this sample. PMID:25458571

Excitations for Rapidly Estimating Flight-Control Parameters

NASA Technical Reports Server (NTRS)

Moes, Tim; Smith, Mark; Morelli, Gene

2006-01-01

A flight test on an F-15 airplane was performed to evaluate the utility of prescribed simultaneous independent surface excitations (PreSISE) for real-time estimation of flight-control parameters, including stability and control derivatives. The ability to extract these derivatives in nearly real time is needed to support flight demonstration of intelligent flight-control system (IFCS) concepts under development at NASA, in academia, and in industry. Traditionally, flight maneuvers have been designed and executed to obtain estimates of stability and control derivatives by use of a post-flight analysis technique. For an IFCS, it is required to be able to modify control laws in real time for an aircraft that has been damaged in flight (because of combat, weather, or a system failure). The flight test included PreSISE maneuvers, during which all desired control surfaces are excited simultaneously, but at different frequencies, resulting in aircraft motions about all coordinate axes. The objectives of the test were to obtain data for post-flight analysis and to perform the analysis to determine: 1) The accuracy of derivatives estimated by use of PreSISE, 2) The required durations of PreSISE inputs, and 3) The minimum required magnitudes of PreSISE inputs. The PreSISE inputs in the flight test consisted of stacked sine-wave excitations at various frequencies, including symmetric and differential excitations of canard and stabilator control surfaces and excitations of aileron and rudder control surfaces of a highly modified F-15 airplane. Small, medium, and large excitations were tested in 15-second maneuvers at subsonic, transonic, and supersonic speeds. Typical excitations are shown in Figure 1. Flight-test data were analyzed by use of pEst, which is an industry-standard output-error technique developed by Dryden Flight Research Center. Data were also analyzed by use of Fourier-transform regression (FTR), which was developed for onboard, real-time estimation of the derivatives.

Social Impact Management Plans: Innovation in corporate and public policy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Franks, Daniel M., E-mail: d.franks@uq.edu.au; Vanclay, Frank, E-mail: frank.vanclay@rug.nl

Social Impact Assessment (SIA) has traditionally been practiced as a predictive study for the regulatory approval of major projects, however, in recent years the drivers and domain of focus for SIA have shifted. This paper details the emergence of Social Impact Management Plans (SIMPs) and undertakes an analysis of innovations in corporate and public policy that have put in place ongoing processes – assessment, management and monitoring – to better identify the nature and scope of the social impacts that might occur during implementation and to proactively respond to change across the lifecycle of developments. Four leading practice examples aremore » analyzed. The International Finance Corporation (IFC) Performance Standards require the preparation of Environmental and Social Management Plans for all projects financed by the IFC identified as having significant environmental and social risks. Anglo American, a major resources company, has introduced a Socio-Economic Assessment Toolbox, which requires mine sites to undertake regular assessments and link these assessments with their internal management systems, monitoring activities and a Social Management Plan. In South Africa, Social and Labour Plans are submitted with an application for a mining or production right. In Queensland, Australia, Social Impact Management Plans were developed as part of an Environmental Impact Statement, which included assessment of social impacts. Collectively these initiatives, and others, are a practical realization of theoretical conceptions of SIA that include management and monitoring as core components of SIA. The paper concludes with an analysis of the implications for the practice of impact assessment including a summary of key criteria for the design and implementation of effective SIMPs. -- Highlights: • Social impact management plans are effective strategies to manage social issues. • They are developed in partnership with regulatory agencies, investors and community. • SIMPs link assessment to ongoing management and address social and community issues. • SIMPs clarify responsibilities in the management of impacts, opportunities and risks. • SIMPs demonstrate a shift to include management as a core component of SIA practice.« less

An open-source solution for advanced imaging flow cytometry data analysis using machine learning.

PubMed

Hennig, Holger; Rees, Paul; Blasi, Thomas; Kamentsky, Lee; Hung, Jane; Dao, David; Carpenter, Anne E; Filby, Andrew

2017-01-01

Imaging flow cytometry (IFC) enables the high throughput collection of morphological and spatial information from hundreds of thousands of single cells. This high content, information rich image data can in theory resolve important biological differences among complex, often heterogeneous biological samples. However, data analysis is often performed in a highly manual and subjective manner using very limited image analysis techniques in combination with conventional flow cytometry gating strategies. This approach is not scalable to the hundreds of available image-based features per cell and thus makes use of only a fraction of the spatial and morphometric information. As a result, the quality, reproducibility and rigour of results are limited by the skill, experience and ingenuity of the data analyst. Here, we describe a pipeline using open-source software that leverages the rich information in digital imagery using machine learning algorithms. Compensated and corrected raw image files (.rif) data files from an imaging flow cytometer (the proprietary .cif file format) are imported into the open-source software CellProfiler, where an image processing pipeline identifies cells and subcellular compartments allowing hundreds of morphological features to be measured. This high-dimensional data can then be analysed using cutting-edge machine learning and clustering approaches using "user-friendly" platforms such as CellProfiler Analyst. Researchers can train an automated cell classifier to recognize different cell types, cell cycle phases, drug treatment/control conditions, etc., using supervised machine learning. This workflow should enable the scientific community to leverage the full analytical power of IFC-derived data sets. It will help to reveal otherwise unappreciated populations of cells based on features that may be hidden to the human eye that include subtle measured differences in label free detection channels such as bright-field and dark-field imagery. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

The Transient Receptor Potential Vanilloid 2 Cation Channel Is Abundant in Macrophages Accumulating at the Peri-Infarct Zone and May Enhance Their Migration Capacity towards Injured Cardiomyocytes following Myocardial Infarction

PubMed Central

Goryainov, Pavel; Landa, Natalie; Barshack, Iris; Avivi, Camila; Semo, Jonathan; Keren, Gad

2014-01-01

Purpose A novel family of transient receptor potential (TRP) channels, that may hold a role in calcium homeostasis, has recently been described. By employing a GeneChip array analysis we have demonstrated a clear and specific upregulation of the TRP vanilloid 2 (TRPV2) mRNA in the left ventricles (LV) 3–5 days post-acute myocardial infarction (MI) compared to sham-operated controls, both in rats and in mice. We sought to characterize the cardiac cellular subpopulations in which TRPV2 is overexpressed upon acute MI. Methods Lewis rats underwent an acute MI by ligation of the left anterior descending artery or chest opening only (sham). The animals were terminated at various time points and an immunohistochemical (IHC) and immunofloerescent (IFC) staining of the LV sections as well as a flow cytometry analysis of LV-derived cells were carried out, using anti-TRPV2 and anti-monocyte/macrophage antibodies. Rat alveolar macrophage cells, NR8383, transiently transfected with TRPV2 siRNA were allowed to migrate towards hypoxic conditioned media of the rat cardiac myoblast line H9C2 using a trans-well migration assay. The macrophage cells migrating to the bottom side of the inserts were counted. Results The IHC and IFC staining as well as the flow cytometry data demonstrated a substantial expression of TRPV2 in infiltrating macrophages in the peri-infarct region 3–5 days post-acute MI. The in vitro migration assay data demonstrated that following inhibition of the TRPV2 channel, the number of migrating macrophages towards conditioned medium of hypoxic cardiomyocytes was significantly reduced. Conclusions TRPV2 is highly expressed on the peri-infarct infiltrating macrophages and may play an important role in post-MI phagocytosis. Better characterization of this channel may pave the way for identifying a new target for modulating the dramatic post-MI immune reactions. PMID:25136832

Formative assessment in physiology teaching using a wireless classroom communication system.

PubMed

Paschal, Cynthia B

2002-12-01

Systems physiology, studied by biomedical engineers, is an analytical way to approach the homeostatic foundations of basic physiology. In many systems physiology courses, students attend lectures and are given homework and reading assignments to complete outside of class. The effectiveness of this traditional approach was compared with an approach in which a wireless classroom communication system was used to provide instant feedback on in-class learning activities and reading assignment quizzes. Homework was eliminated in this approach. The feedback system used stimulated 100% participation in class and facilitated rapid formative assessment. The results of this study indicate that learning of systems physiology concepts including physiology is at least, as if not more, effective when in-class quizzes and activities with instant feedback are used in place of traditional learning activities including homework. When results of this study are interpreted in light of possible effects of the September 11, 2001 terrorist attacks on student learning in the test group, it appears that the modified instruction may be more effective than the traditional instruction.

Estimation of Stability and Control Derivatives of an F-15

NASA Technical Reports Server (NTRS)

Smith, Mark; Moes, Tim

2006-01-01

A technique for real-time estimation of stability and control derivatives (derivatives of moment coefficients with respect to control-surface deflection angles) was used to support a flight demonstration of a concept of an indirect-adaptive intelligent flight control system (IFCS). Traditionally, parameter identification, including estimation of stability and control derivatives, is done post-flight. However, for the indirect-adaptive IFCS concept, parameter identification is required during flight so that the system can modify control laws for a damaged aircraft. The flight demonstration was carried out on a highly modified F-15 airplane (see Figure 1). The main objective was to estimate the stability and control derivatives of the airplane in nearly real time. A secondary goal was to develop a system to automatically assess the quality of the results, so as to be able to tell a learning neural network which data to use. Parameter estimation was performed by use of Fourier-transform regression (FTR) a technique developed at NASA Langley Research Center. FTR is an equation- error technique that operates in the frequency domain. Data are put into the frequency domain by use of a recursive Fourier transform for a discrete frequency set. This calculation simplifies many subsequent calculations, removes biases, and automatically filters out data beyond the chosen frequency range. FTR as applied here was tailored to work with pilot inputs, which produce correlated surface positions that prevent accurate parameter estimates, by replacing half the derivatives with predicted values. FTR was also set up to work only on a recent window of data, to accommodate changes in flight condition. A system of confidence measures was developed to identify quality-parameter estimates that a learning neural network could use. This system judged the estimates primarily on the basis of their estimated variances and of the level of aircraft response. The resulting FTR system was implemented in the Simulink software system and auto-coded in the C programming language for use on the Airborne Research Test System (ARTS II) computer installed in the F-15 airplane. The Simulink model was also used in a control room that utilizes the Ring Buffered Network Bus hardware and software, making it possible to evaluate test points during flights. In-flight parameter estimation was done for piloted and automated maneuvers, primarily at three test conditions. Figure 2 shows results for pitching moment due to symmetric stabilator actuations for a series of three pitch doublet maneuvers (in a doublet maneuver, a command to change attitude in a given direction by a given amount is followed immediately by a command to change attitude in the opposite direction by the same amount). A time window of 5 seconds was used. The portions of the curves shown in red are those that passed the confidence tests. The technique showed good convergence for most derivatives for both kinds of maneuvers - typically within a few seconds. The confidence tests were marginally successful, and it would be necessary to refine them for use in an IFCS.

pyGFC - A Python Extension to the C++ Geodesy Foundation Classes

DTIC Science & Technology

2008-09-01

imperative for a successful emulation of a dynamic MANET as intended. To achieve this objective, the same algorithm and its implementation for...solution has two options: (1) selecting, implementing, and integrating an appropriate algorithm into the tool and in the MANE system, or (2) using an...GFCCoord *estimate_southeast_coords(double, double); double lat; double lon; double alt; private: CEarth *earth; char * cstr

Training Master's-Level Graduate Students to Use Inquiry Instruction to Teach Middle-Level and High-School Science Concepts

ERIC Educational Resources Information Center

Gilman, Sharon Larimer; Hitt, Austin M.; Gilman, Craig

2015-01-01

Through the GK-12 program of the National Science Foundation, graduate student fellows in a coastal marine and wetland studies program were trained to present targeted science concepts to middle- and high-school classes through their own research-based lessons. Initially, they were taught to follow the 5-E learning cycle in lesson plan…

MBA Admissions Requirements as Predictors of Motivational Beliefs and Self-Regulatory Strategies in Self-Selected Online MBA Students

ERIC Educational Resources Information Center

Salik, Steven H.

2010-01-01

Driven by a variety of factors, online learning has continued to grow at an unprecedented rate. A Sloan Foundation report issued in January of 2010 indicated that in 2009, 4.6 million students took at least one online class, an increase in 17% over 2008. Graduate business education, and more specifically, Master of Business Administration (MBA)…

FUNCTION Follows FORM: Building the Foundations for Student Achievement Employing "School as a Teaching Tool" Protocol a Place-Based Learning Approach

ERIC Educational Resources Information Center

da Silva, Joseph; Alvarado, Manuel Cordero

2011-01-01

The experience of observing students actively engaged in the learning process is precious. There is no better way to celebrate "Children's Health and Energy Awareness Month" than assembling in a world class high performance green school with gifted and talented students learning how to take an integrated approach to sustainable school…

What the United States Can Learn From Singapore's World-Class Mathematics System (and What Singapore Can Learn from the United States): An Exploratory Study

ERIC Educational Resources Information Center

Ginsburg, Alan; Leinwand, Steven; Anstrom, Terry; Pollock, Elizabeth

2005-01-01

This exploratory study compares key features of the Singapore and U.S. mathematics systems in the primary grades, when students need to build a strong mathematics foundation. It identifies major differences between the mathematics frameworks, textbooks, assessments, and teachers in Singapore and the United States. It also presents initial results…

A Discrete Latent State Approach to Diagnostic Testing. Final Report on Contract Number N00014-81-K-0564.

ERIC Educational Resources Information Center

Paulson, James A.

This paper reports on a project which has developed the general latent class model as a framework for representation of item responses. This framework can be used to represent data in applications such as mastery tests and other kinds of achievement tests, where there is reason to believe that current foundations are deficient. Methods of…

The Effect of the United States Naval Academy Foundation Preparatory Program on the Performance of Naval Academy Midshipmen

DTIC Science & Technology

2004-12-01

final two sections cover the research methods to analyze the performance of USNA Midshipmen. The United States Naval Academy’s Class of 2007 includes... Research Methods for Organizational Studies. Mahwah, New Jersey: Lawrence Erlbaum Associates. SECNAV INSTRUCTION 1531.2A. (1996). U.S. Naval...METHODOLOGY ..............................3 1. Research Questions ............................3 2. Scope .........................................4 3

Examining the Theoretical Factors That Influence University Students to Adopt Web 2.0 Technologies: The Australian Perspective

ERIC Educational Resources Information Center

Al-Otaibi, Yasser D.; Houghton, Luke

2015-01-01

The purpose of this study is (1) to examine Australian university students' awareness of the benefits of Web 2.0 technologies and (2) to investigate the factors that influence students to adopt Web 2.0 technologies to supplement in-class learning, using the theoretical foundations of both Theory of Planned Behaviour (TPB) and Decomposed Theory of…

The Implementation and Effects of the Literacy Design Collaborative (LDC): Early Findings in Sixth-Grade Advanced Reading Courses. CRESST Report 846

ERIC Educational Resources Information Center

Herman, Joan L.; Epstein, Scott; Leon, Seth; Dai, Yunyun; La Torre Matrundola, Deborah; Reber, Sarah; Choi, Kilchan

2015-01-01

The Bill and Melinda Gates Foundation invested in the Literacy Design Collaborative (LDC) as one strategy to support teachers' and students' transition to the Common Core State Standards (CCSS) in English language arts. This report provides an early look at the implementation of LDC in sixth-grade Advanced Reading classes in a large Florida…

A Journey of Change with a Big Blue Whale: A Theatre-in-Education (TIE) Programme on Disability and Dilemmas in the Inclusive Classroom in Korea

ERIC Educational Resources Information Center

Kim, Byoung-Joo

2009-01-01

The article chronicles and discusses "A Big Blue Whale's Dream," one of the first major theatre-in-education (TIE) projects commissioned by local and governmental cultural foundations in South Korea. Designed specifically for the non-disabled fifth and sixth graders of Inclusive Classes to enhance their awareness and perception towards…

Using an International p53 Mutation Database as a Foundation for an Online Laboratory in an Upper Level Undergraduate Biology Class

ERIC Educational Resources Information Center

Melloy, Patricia G.

2015-01-01

A two-part laboratory exercise was developed to enhance classroom instruction on the significance of p53 mutations in cancer development. Students were asked to mine key information from an international database of p53 genetic changes related to cancer, the IARC TP53 database. Using this database, students designed several data mining activities…

Disruptive Fixation: School Reform and the Pitfalls of Techno-Idealism. Princeton Studies in Culture and Technology Series

ERIC Educational Resources Information Center

Sims, Christo

2017-01-01

In New York City in 2009, a new kind of public school opened its doors to its inaugural class of middle schoolers. Conceived by a team of game designers and progressive educational reformers and backed by prominent philanthropic foundations, it promised to reinvent the classroom for the digital age. Ethnographer Christo Sims documented the life of…

Theoretical study on electronic structure and thermoelectric properties of PbS x Te1-x (x = 0.25, 0.5, and 0.75) solid solution

NASA Astrophysics Data System (ADS)

Lu, Yong; Li, Kai-yue; Zhang, Xiao-lin; Huang, Yan; Shao, Xiao-hong

2018-02-01

Not Available Project supported by the National Natural Science Foundation of China (Grant Nos. 11647010 and 11704020), the Higher Education and High-quality and World-class Universities (Grant No. PY201611), and the Fund for Disciplines Construction from Beijing University of Chemical Technology (Grant No. XK1702).

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 11 (Hilton Systems Inc -International Industries Inc)

DTIC Science & Technology

1990-01-01

A11 10 m 4(1 CI (00 10 <D 0 1(0 (4 -1 -*It j-I -ti j 1 -114 -14 1N N r > KfC i i-I - of ’D I <( m it 4 44 LAO<< U)U IL- C LAO L𔃻 ~ I- Ai>> tor)> LNMMM...4 if Z InIn In in n toIn tr onIn In Z.10- 01 o( c > ) In In n InfLn InL In I n 20 C ZIn InfIn Z In 11. if-c I (0-4 11Ir nV no U1(1() on C )() 0 I a1

NASA #837 Tribute The Jet with a Thousand Faces

NASA Technical Reports Server (NTRS)

Rhoades, Carrie M.

2009-01-01

This slide presentation reviews the TF-1 (later designated as an F-15B) aircraft, which was delivered as an F-15 trainer. The aircraft was used as a test aircraft for various programs. The aircraft was later renamed to NASA 837 in 2001. Prior to its retirement it was used to test various features and concepts. Some of these tests were: (1) Canopy Off Testing, (2) STOL and Maneuvering Technology Demonstrator (S/MTD), (3) 2D Nozzles (4) Autonomous landing guidance, (5) Advanced Control Technology for Integrated Vehicles (ACTIVE), (6) Intelligent Flight Control System (IFCS), (7) Structural Loads Model Validation (SLMV), (8) Enhanced Communication and Navigation System (ECANS), (9) QuietSpike Probing, and (10) Lift and Nozzle Effects on Tail Shocks (LaNCETS)

BOREAS TE-5 Diurnal CO2 Canopy Profile Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Ehleriinger, Jim; Brooks, J. Renee; Flanagan, Larry

2000-01-01

The BOREAS TE-5 team collected several data sets to investigate the vegetation-atmosphere CO2 and H2O exchange processes. These data were collected to provide detailed information within the canopy during times when TE-05 sampled canopy CO2 for carbon and oxygen isotope analysis. These measurements were made in both the NSA and SSA at the OJP, OBS, UBS, and OA sites from 25-May1994 to 08-Sep1994. CO2 profile data were not collected at SSA-OA during the first IFC. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Activity Archive Center (DAAC).

Compressed Natural Gas Vehicle Maintenance Facility Modification Handbook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kelly, K.; Melendez, M.; Gonzales, J.

To ensure the safety of personnel and facilities, vehicle maintenance facilities are required by law and by guidelines of the National Fire Protection Association (NFPA) and the International Fire Code (IFC) to exhibit certain design features. They are also required to be fitted with certain fire protection equipment and devices because of the potential for fire or explosion in the event of fuel leakage or spills. All fuels have an explosion or fire potential if specific conditions are present. This handbook covers the primary elements that must be considered when developing a CNG vehicle maintenance facility design that will protectmore » against the ignition of natural gas releases. It also discusses specific protocols and training needed to ensure safety.« less

Thyra Abstract Interface Package

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartlett, Roscoe A.

2005-09-01

Thrya primarily defines a set of abstract C++ class interfaces needed for the development of abstract numerical atgorithms (ANAs) such as iterative linear solvers, transient solvers all the way up to optimization. At the foundation of these interfaces are abstract C++ classes for vectors, vector spaces, linear operators and multi-vectors. Also included in the Thyra package is C++ code for creating concrete vector, vector space, linear operator, and multi-vector subclasses as well as other utilities to aid in the development of ANAs. Currently, very general and efficient concrete subclass implementations exist for serial and SPMD in-core vectors and multi-vectors. Codemore » also currently exists for testing objects and providing composite objects such as product vectors.« less

Pain: Systematic Review of Pharmacy Compounding of Pain Medication.

PubMed

Shawaqfeh, Mohammad S; Harrington, Catherine

2018-01-01

There are limited resources available for pharmacists and doctors to reference proper compounded formulas for pain medications. The systematic review discussed within this article provides the foundation for a searchable database, allowing users to find various compounded formulations. It also provides data about the safety and efficacy of the preparations. Compounding information about several drug classes was reviewed. Those drug classes included, but were not limited to, opioids, non-steroidal anti-inflammatory drugs, central nervous system agents, and anesthetics, with evidence that of the various drugs that could be compounded for pain, anesthetics, non-steroidal anti-inflammatory drugs, and opioids ranked highest within the articles researched. Copyright© by International Journal of Pharmaceutical Compounding, Inc.

Working toward equitable opportunities for science students with disabilities: using professional development and technology.

PubMed

Bargerhuff, Mary Ellen; Cowan, Heidi; Kirch, Susan A

2010-01-01

As a result of federal legislation, adolescents with disabilities and other exceptionalities are increasingly included in science and math classes alongside their peers who are typically developing. The effectiveness of this placement option, however, is largely dependent on the skill level of the general educator and the support afforded to this teacher through various channels. Efforts arising from two National Science Foundation grants address both skill and support. Center's Lesson Adaptations for Student Success (CLASS) project used summer professional development opportunities to equip teachers with the knowledge and skills needed to provide students with physical, sensory and learning disabilities equitable access to laboratory and field experiences. Second, to support teachers back in their classrooms, the Ohio Resource Center's Lesson Adaptations for Student Success (OR-CLASS) uses web resources to share high quality, peer-reviewed lesson plans, complete with specific recommendations on adaptations for students with a variety of exceptional learning needs.

MRP (materiel requirements planning) II implementation: a case study.

PubMed

Sheldon, D

1994-05-01

Manufacturing resource planning (MRP II) is a powerful and effective business planning template on which to build a continuous improvement culture. MRP II, when successfully implemented, encourages a disciplined yet nonthreatening environment centered on measurement and accountability. From the education that accompanies an MRP II implementation, the employees can better understand the vision and mission of the organization. This common goal keeps everyone's energy directed toward the same final objective. The Raymond Corporation is a major materiels handling equipment manufacturer headquartered in Greene, New York, with class "A" MRP II manufacturing facilities in Greene and Brantford, Ontario and an aftermark distribution facility in East Syracuse, New York. Prior to the implementation of MRP II in its Greene plant (from 1988 through 1990) good intentions and hard work were proving to be less than necessary to compete in the global market. Certified class "A" in February 1990. The Raymond Corporation has built a world-class organization from these foundations.

Framing discourse for optimal learning in science and mathematics

NASA Astrophysics Data System (ADS)

Megowan, Mary Colleen

2007-12-01

This study explored the collaborative thinking and learning that occurred in physics and mathematics classes where teachers practiced Modeling Instruction. Four different classes were videotaped---a middle school mathematics resource class, a 9th grade physical science class, a high school honors physics class and a community college engineering physics course. Videotapes and transcripts were analyzed to discover connections between the conceptual structures and spatial representations that shaped students' conversations about space and time. Along the way, it became apparent that students' and teachers' cultural models of schooling were a significant influence, sometimes positive and sometimes negative, in students' engagement and metaphor selection. A growing number of researchers are exploring the importance of semiotics in physics and mathematics, but typically their unit of analysis is the individual student. To examine the distributed cognition that occurred in this unique learning setting, not just among students but also in connection with their tools, artifacts and representations, I extended the unit of analysis for my research to include small groups and their collaborative work with whiteboarded representations of contextual problems and laboratory exercises. My data revealed a number of interesting insights. Students who constructed spatial representations and used them to assist their reasoning, were more apt to demonstrate a coherent grasp of the elements, operations, relations and rules that govern the model under investigation than those who relied on propositional algebraic representations of the model. In classrooms where teachers permitted and encouraged students to take and hold the floor during whole-group discussions, students learned to probe one another more deeply and conceptually. Shared representations (whether spatial or propositional/algebraic), such as those that naturally occurred when students worked together in small groups to prepare collaborative displays of their thinking, were more apt to stimulate conceptually oriented conversations among students than individual work, i.e., what each student had written on his or her worksheet. This research was supported, in part, by grants from the National Science Foundation (#0337795 and #0312038). Any opinions, findings, conclusions or recommendations expressed herein are those of the author and do not necessarily reflect the views of the National Science Foundation.

Pitfalls in alignment of observation models resolved using PROV as an upper ontology

NASA Astrophysics Data System (ADS)

Cox, S. J. D.

2015-12-01

A number of models for observation metadata have been developed in the earth and environmental science communities, including OGC's Observations and Measurements (O&M), the ecosystems community's Extensible Observation Ontology (OBOE), the W3C's Semantic Sensor Network Ontology (SSNO), and the CUAHSI/NSF Observations Data Model v2 (ODM2). In order to combine data formalized in the various models, mappings between these must be developed. In some cases this is straightforward: since ODM2 took O&M as its starting point, their terminology is almost completely aligned. In the eco-informatics world observations are almost never made in isolation of other observations, so OBOE pays particular attention to groupings, with multiple atomic 'Measurements' in each oboe:Observation which does not have a result of its own and thus plays a different role to an om:Observation. And while SSN also adopted terminology from O&M, mapping is confounded by the fact that SSN uses DOLCE as its foundation and places ssn:Observations as 'Social Objects' which are explicitly disjoint from 'Events', while O&M is formalized as part of the ISO/TC 211 harmonised (UML) model and sees om:Observations as value assignment activities. Foundational ontologies (such as BFO, GFO, UFO or DOLCE) can provide a framework for alignment, but different upper ontologies can be based in profoundly different worldviews and use of incommensurate frameworks can confound rather than help. A potential resolution is provided by comparing recent studies that align SSN and O&M, respectively, with the PROV-O ontology. PROV-O provides just three base classes: Entity, Activity and Agent. om:Observation is sub-classed from prov:Activity, while ssn:Observation is sub-classed from prov:Entity. This confirms that, despite the same name, om:Observation and ssn:Observation denote different aspects of the observation process: the observation event, and the record of the observation event, respectively. Alignment with the simple PROV-O classes has clarified this issue in a way that had previously proved difficult to resolve. The simple 3-class base model from PROV appears to provide just enough logic to serve as a lightweight upper ontology, particularly for workflow or process-based information.

Characterization of swine leukocyte antigen alleles and haplotypes on a novel miniature pig line, Microminipig.

PubMed

Ando, A; Imaeda, N; Ohshima, S; Miyamoto, A; Kaneko, N; Takasu, M; Shiina, T; Kulski, J K; Inoko, H; Kitagawa, H

2014-12-01

Microminipigs are extremely small-sized, novel miniature pigs that were recently developed for medical research. The inbred Microminipigs with defined swine leukocyte antigen (SLA) haplotypes are expected to be useful for allo- and xenotransplantation studies and also for association analyses between SLA haplotypes and immunological traits. To establish SLA-defined Microminipig lines, we characterized the polymorphic SLA alleles for three class I (SLA-1, SLA-2 and SLA-3) and two class II (SLA-DRB1 and SLA-DQB1) genes of 14 parental Microminipigs using a high-resolution nucleotide sequence-based typing method. Eleven class I and II haplotypes, including three recombinant haplotypes, were found in the offspring of the parental Microminipigs. Two class I and class II haplotypes, Hp-31.0 (SLA-1*1502-SLA-3*070102-SLA-2*1601) and Hp-0.37 (SLA-DRB1*0701-SLA-DQB1*0502), are novel and have not so far been reported in other pig breeds. Crossover regions were defined by the analysis of 22 microsatellite markers within the SLA class III region of three recombinant haplotypes. The SLA allele and haplotype information of Microminipigs in this study will be useful to establish SLA homozygous lines including three recombinants for transplantation and immunological studies. © 2014 Stichting International Foundation for Animal Genetics.

Influence of the Soil Genesis on Physical and Mechanical Properties

PubMed Central

Marschalko, Marian; Yilmaz, Işık; Fojtová, Lucie; Kubečka, Karel; Bouchal, Tomáš; Bednárik, Martin

2013-01-01

The paper deals with the influence of soil genesis on the physical-mechanical properties. The presented case study was conducted in the region of the Ostrava Basin where there is a varied genetic composition of the Quaternary geological structure on the underlying Neogeneous sediments which are sediments of analogous granulometry but different genesis. In this study, 7827 soil samples of an eolian, fluvial, glacial, and deluvial origin and their laboratory analyses results were used. The study identified different values in certain cases, mostly in coarser-grained foundation soils, such as sandy loam S4 (MS) and clayey sand F4 (CS). The soils of the fluvial origin manifest different values than other genetic types. Next, based on regression analyses, dependence was proved neither on the deposition depth (depth of samples) nor from the point of view of the individual foundation soil classes or the genetic types. The contribution of the paper is to point at the influence of genesis on the foundation soil properties so that engineering geologists and geotechnicians pay more attention to the genesis during engineering-geological and geotechnical investigations. PMID:23844398

Health risks, social relations and class: an analysis of occupational health discourse in Finnish newspaper and women's magazine articles 1961-2008.

PubMed

Varje, Pekka; Väänänen, Ari

2016-03-01

In this article we examine the treatment of psychosocial risks in public occupational health discourse in Finnish newspaper and magazine articles between the 1960s and 2000s, using discourse analysis. Building on class theories, our aim is to investigate how class expectations have been linked with the redefinition of occupational health risks during this period. Our results suggest that as social relations at the workplace became problematised in the occupational health discussions after the 1970s, the image of the hierarchical and naturally conflictual organisation was replaced by idealised middle-class notions of smoothly functioning, harmonious organisations that offered rewarding work experiences. However, this same period since the late 1970s has also been characterised by increasing economic competition and neoliberal market ideology. We conclude that the concern about work-related psychosocial risks and health problems expressed in Finnish newspaper and magazine articles during the last three decades has been shaped in many respects by a collision between the dominant middle-class expectations of harmony and equality and the neoliberal production of competition and inequality. © 2015 Foundation for the Sociology of Health & Illness.

Economic Education Experiences of Enterprising Teachers, Volume 13. A Report Developed from the 1974-75 Entries in The International Paper Company Foundation Awards Program for the Teaching of Economics.

ERIC Educational Resources Information Center

Dawson, George G., Ed.

The publication outlines 19 award winning economic education projects for use on levels K through college. The projects have been judged original and interesting to students and have met contest criteria by describing class situation, scope and sequence, goals, motivational devices, teaching techniques, samples of student work, culmination…

Classification of Dark Modified KdV Equation

NASA Astrophysics Data System (ADS)

Xiong, Na; Lou, Sen-Yue; Li, Biao; Chen, Yong

2017-07-01

The dark Korteweg-de Vries (KdV) systems are defined and classified by Kupershmidt sixteen years ago. However, there is no other classifications for other kinds of nonlinear systems. In this paper, a complete scalar classification for dark modified KdV (MKdV) systems is obtained by requiring the existence of higher order differential polynomial symmetries. Different to the nine classes of the dark KdV case, there exist twelve independent classes of the dark MKdV equations. Furthermore, for the every class of dark MKdV system, there is a free parameter. Only for a fixed parameter, the dark MKdV can be related to dark KdV via suitable Miura transformation. The recursion operators of two classes of dark MKdV systems are also given. Supported by the Global Change Research Program of China under Grant No. 2015Cb953904, National Natural Science Foundation of China under Grant Nos. 11675054, 11435005, 11175092, and 11205092 and Shanghai Knowledge Service Platform for Trustworthy Internet of Things (No. ZF1213) and K. C. Wong Magna Fund in Ningbo University

The development of loneliness from mid- to late adolescence: trajectory classes, personality traits, and psychosocial functioning.

PubMed

Vanhalst, Janne; Goossens, Luc; Luyckx, Koen; Scholte, Ron H J; Engels, Rutger C M E

2013-12-01

Although loneliness is a common problem across late adolescence, its developmental course has not been investigated in depth in this period of life. The present study aims to fill this gap by means of a five-wave cohort-sequential longitudinal study spanning ages 15 to 20 (N = 389). Both variable-centered (i.e., latent growth curve modeling) and person-centered (i.e., latent class growth analysis) approaches were used. Variable-centered analyses showed that loneliness generally decreased over time. Person-centered analyses pointed to considerable inter-individual differences in the development of loneliness, and identified five trajectory classes (i.e., stable low, low increasing, moderate decreasing, high increasing, and chronically high). These five trajectory classes were differentially related to personality traits at age 15 (i.e., extraversion, agreeableness, and emotional stability) and psychosocial functioning at age 20 (i.e., depressive symptoms, self-esteem, anxiety, and perceived stress). These findings underscore the additional value of studying subgroups regarding the development of loneliness. Copyright © 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

The moderating effect of the need to belong and classroom composition on belongingness seeking of minority adolescents.

PubMed

Kuo, Fu Wen; Yang, Shu Ching

2017-12-01

This study aimed to elucidate whether the interaction of classroom composition and the need to belong influences belongingness seeking and, if so, to investigate how upward comparison mediates the effects. The analyses were conducted with a cross-sectional sample of 383 Taiwanese aboriginal adolescents (39.7% male) recruited from schools with mixed-sex/ethnicity (n = 113), single-sex (n = 122), and minority-only (n = 148) classrooms. After controlling for socioeconomic status, the moderation analyses indicated that participants with a chronic need to belong in classes with diversity (mixed sex/ethnicity) perceived higher social acceptance, while those with a chronic need to belong in homogeneous classes (single-sex and minority-only) reported greater feelings of rejection. Upward comparison for differentiation was found to influence the indirect effects of the need to belong on feelings of rejection and depression in single-sex and minority-only classes. In particular, the mediating effect of upward comparison was stronger in minority-only classes. Copyright © 2017 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

The Nature of Quantum Truth: Logic, Set Theory, & Mathematics in the Context of Quantum Theory

NASA Astrophysics Data System (ADS)

Frey, Kimberly

The purpose of this dissertation is to construct a radically new type of mathematics whose underlying logic differs from the ordinary classical logic used in standard mathematics, and which we feel may be more natural for applications in quantum mechanics. Specifically, we begin by constructing a first order quantum logic, the development of which closely parallels that of ordinary (classical) first order logic --- the essential differences are in the nature of the logical axioms, which, in our construction, are motivated by quantum theory. After showing that the axiomatic first order logic we develop is sound and complete (with respect to a particular class of models), this logic is then used as a foundation on which to build (axiomatic) mathematical systems --- and we refer to the resulting new mathematics as "quantum mathematics." As noted above, the hope is that this form of mathematics is more natural than classical mathematics for the description of quantum systems, and will enable us to address some foundational aspects of quantum theory which are still troublesome --- e.g. the measurement problem --- as well as possibly even inform our thinking about quantum gravity. After constructing the underlying logic, we investigate properties of several mathematical systems --- e.g. axiom systems for abstract algebras, group theory, linear algebra, etc. --- in the presence of this quantum logic. In the process, we demonstrate that the resulting quantum mathematical systems have some strange, but very interesting features, which indicates a richness in the structure of mathematics that is classically inaccessible. Moreover, some of these features do indeed suggest possible applications to foundational questions in quantum theory. We continue our investigation of quantum mathematics by constructing an axiomatic quantum set theory, which we show satisfies certain desirable criteria. Ultimately, we hope that such a set theory will lead to a foundation for quantum mathematics in a sense which parallels the foundational role of classical set theory in classical mathematics. One immediate application of the quantum set theory we develop is to provide a foundation on which to construct quantum natural numbers, which are the quantum analog of the classical counting numbers. It turns out that in a special class of models, there exists a 1-1 correspondence between the quantum natural numbers and bounded observables in quantum theory whose eigenvalues are (ordinary) natural numbers. This 1-1 correspondence is remarkably satisfying, and not only gives us great confidence in our quantum set theory, but indicates the naturalness of such models for quantum theory itself. We go on to develop a Peano-like arithmetic for these new "numbers," as well as consider some of its consequences. Finally, we conclude by summarizing our results, and discussing directions for future work.

The Design and Validation of the Colorado Learning Attitudes about Science Survey

NASA Astrophysics Data System (ADS)

Adams, W. K.; Perkins, K. K.; Dubson, M.; Finkelstein, N. D.; Wieman, C. E.

2005-09-01

The Colorado Learning Attitudes about Science Survey (CLASS) is a new instrument designed to measure various facets of student attitudes and beliefs about learning physics. This instrument extends previous work by probing additional facets of student attitudes and beliefs. It has been written to be suitably worded for students in a variety of different courses. This paper introduces the CLASS and its design and validation studies, which include analyzing results from over 2400 students, interviews and factor analyses. Methodology used to determine categories and how to analyze the robustness of categories for probing various facets of student learning are also described. This paper serves as the foundation for the results and conclusions from the analysis of our survey data.

Slope effects on shortwave radiation components and net radiation

NASA Technical Reports Server (NTRS)

Walter-Shea, Elizabeth A.; Blad, Blaine L.; Hays, Cynthia J.; Mesarch, Mark A.

1992-01-01

The main objective of the International Satellite Land Surface Climatology Project (ISLSCP) has been stated as 'the development of techniques that may be applied to satellite observations of the radiation reflected and emitted from the Earth to yield quantitative information concerning land surface climatological conditions.' The major field study, FIFE (the First ISLSCP Field Experiment), was conducted in 1978-89 to accomplish this objective. Four intensive field campaigns (IFC's) were carried out in 1987 and one in 1989. Factors contributing to observed reflected radiation from the FIFE site must be understood before the radiation observed by satellites can be used to quantify surface processes. Analysis since our last report has focused on slope effects on incoming and outgoing shortwave radiation and net radiation from data collected in 1989.

Fresenius AS.TEC204 blood cell separator.

PubMed

Sugai, Mikiya

2003-02-01

Fresenius AS.TEC204 is a third-generation blood cell separator that incorporates the continuous centrifugal separation method and automatic control of the cell separation process. Continuous centrifugation separates cell components according to their specific gravity, and different cell components are either harvested or eliminated as needed. The interface between the red blood cell and plasma is optically detected, and the Interface Control (IFC) cooperates with different pumps, monitors and detectors to harvest required components automatically. The system is composed of three major sections; the Front Panel Unit; the Pump Unit, and the Centrifuge Unit. This unit can be used for a wide variety of clinical applications including collection of platelets, peripheral blood stem cells, bone marrow stem cells, granulocytes, mononuclear cells, and exchange of plasma or red cells, and for plasma treatment.

Single-Cell RNA Sequencing of Glioblastoma Cells.

PubMed

Sen, Rajeev; Dolgalev, Igor; Bayin, N Sumru; Heguy, Adriana; Tsirigos, Aris; Placantonakis, Dimitris G

2018-01-01

Single-cell RNA sequencing (sc-RNASeq) is a recently developed technique used to evaluate the transcriptome of individual cells. As opposed to conventional RNASeq in which entire populations are sequenced in bulk, sc-RNASeq can be beneficial when trying to better understand gene expression patterns in markedly heterogeneous populations of cells or when trying to identify transcriptional signatures of rare cells that may be underrepresented when using conventional bulk RNASeq. In this method, we describe the generation and analysis of cDNA libraries from single patient-derived glioblastoma cells using the C1 Fluidigm system. The protocol details the use of the C1 integrated fluidics circuit (IFC) for capturing, imaging and lysing cells; performing reverse transcription; and generating cDNA libraries that are ready for sequencing and analysis.

On the Wing: A Business-Class Jet

NASA Technical Reports Server (NTRS)

1998-01-01

Cessna Aircraft Company was last featured in Spinoff 1991 for the Citation Jet, the industry's current best selling business jet. The newest addition to its fleet is the Citation X (ten), the largest, most complex aircraft ever produced by Cessna, which also has its basis in NASA technology. Aerodynamic design, wind tunneling testing, and airfoil performance, for example, have their foundation with NASA. The Citation X is the fastest, most efficient business jet ever built.

KSC-2012-2733

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, shuttle astronauts Franklin Chang Diaz, at left, Kevin Chilton and Charlie Precourt stand together after being inducted into the U.S. Astronaut Hall of Fame Class of 2012. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

The Historical Formation of Modern Education and the Junction of the "Educational Lower Class": Poor Education as the Denominator of Social Position and Status in the Nineteenth and Twentieth Centuries in Finland

ERIC Educational Resources Information Center

Rinne, Risto; Kivirauma, Joel

2005-01-01

Modern industrial society liberated the sources of livelihood, gave birth to salaried labour and began to cater for social mobility, i.e. broke the foundations of traditional estate society. Traditional trades and socialization mechanisms attached to families were replaced by mass production and education. Education played a crucial role in the…

The Use of Makaton for Supporting Talk, through Play, for Pupils Who have English as an Additional Language (EAL) in the Foundation Stage

ERIC Educational Resources Information Center

Mistry, Malini; Barnes, Danielle

2013-01-01

This study examines the use of Makaton® , a language programme based on the use of signing, symbols and speech, as a pedagogic tool to support the development of talk for pupils learning English as an Additional Language (EAL). The research setting was a Reception class with a high percentage of pupils who have EAL in the initial stages of…

Augmenting Latent Dirichlet Allocation and Rank Threshold Detection with Ontologies

DTIC Science & Technology

2010-03-01

Probabilistic Latent Semantic Indexing (PLSI) is an automated indexing information retrieval model [20]. It is based on a statistical latent class model which is...uses a statistical foundation that is more accurate in finding hidden semantic relationships [20]. The model uses factor analysis of count data, number...principle of statistical infer- ence which asserts that all of the information in a sample is contained in the likelihood function [20]. The statistical

What does it take to create an effective and interactive learning environment with 700 students in a college Gen. Ed. Astro Course?

NASA Astrophysics Data System (ADS)

Prather, Edward E.; Brissenden, G.; Cormier, S.; Eckenrode, J.; Collaboration of Astronomy Teaching Scholars CATS

2012-01-01

College-level general education (gen ed.) curricula in the US have many goals: exposing students to the breadth of human ideas; elevating their reading comprehension, writing abilities, critical reasoning skills; and providing an understanding of, and appreciation for, subjects outside of their chosen field of study. Unfortunately the majority of the teaching and learning for gen ed. courses takes place in large enrollment courses. In the wake of the recent US financial crisis, many institutions of higher learning face extreme budget cuts, leading many faculty to teach in substantially larger classes with increasingly fewer resources. At the University of Arizona this issue manifests itself in mega-classes with enrollments from 700-1400. We discuss key programmatic and pedagogical changes involved in successfully implementing proven collaborative learning strategies into an Astro 101 mega-class. From devising new ways to hand out and collect papers, to altering course seating, to outlawing cell phones and laptops, to implementing new ways of administering tests. We take a "what ever it takes” approach to engineering this mega-course environment so it can succeed as a learner-centered classroom. Paramount to the success of this course has been the creation of the new CAE Ambassadors program which advances the leadership role of prior non-science majors along the continuum from student, to teaching assistant, to science education researcher, to STEM minor. This material is based in part upon work supported by the National Science Foundation under Grant No. 0715517, a CCLI Phase III Grant for the Collaboration of Astronomy Teaching Scholars (CATS). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

Media communication strategies for climate-friendly lifestyles - Addressing middle and lower class consumers for social-cultural change via Entertainment-Education

NASA Astrophysics Data System (ADS)

Lubjuhn, S.; Pratt, N.

2009-11-01

This paper argues that Entertainment-Education (E-E) is a striking communication strategy for reaching middle and lower socio-economic classes with climate-friendly lifestyle messages. On the international level (e.g. in the US and the Netherlands) E-E approaches are being theoretically grounded, whereas in Germany they are not yet. Therefore further theoretical discussion and mapping of E-E approaches is central for future research. As a first step towards providing further theoretical foundations for E-E in the field of sustainability, the authors suggest a threefold mapping of E-E approaches. The threefold mapping of E-E approaches for communicating climate-friendly lifestyles to middle and lower class consumers is based on recent results from academic research and practical developments on the media market. The commonalities among the three is that they all promote pro-sustainability messages in an affective-orientated rather than cognitive-orientated, factual manner. Differences can be found in: the sender of the sustainability message, the targeted consumer groups and the media approach in use. Based on this, the paper draws the conclusion that two new paths for further research activities in the field of Entertainment-Education can be proposed: (1) Improving the existing approaches in practice by using theoretical foundation from the E-E field. This comprises at its core (A) to do formative, process and summative effect research on the messages and (B) to use E-E theory from the field of social psychology, sociology and communication science for further improvement and (2) Generating new E-E theories by analyzing the existing practical approaches in the media to communicate climate change.

A 0.02% THD and 80 dB PSRR filterless class D amplifier with direct lithium battery hookup in mobile application

NASA Astrophysics Data System (ADS)

Zheng, Hao; Zhu, Zhangming; Ma, Rui

2017-07-01

This paper presents a fully integrated CMOS filterless class D amplifier that can directly hook up lithium battery in mobile application The proposed amplifier embodies a 2-order feedback path architecture instead of direct feedback of output to input of the integrator to decrease the high frequency intermodulation distortion associated with direct feedback and eliminate the integrator input common mode disturbance from the output in ternary modulation. The prototype class D amplifier realized in 0.35 μm digital technology achieves a THD+N of 0.02% when delivering 400 mW to an 8 {{Ω }} load from {V}{DD}=3.6 {{V}}. The PSRR of the prototype class D amplifier is 80 dB at 217 Hz. Furthermore a filterless method that can eliminate the external LC filter is employed which offers great advantages of saving PCB space and lowering system cost. In addition the prototype class D amplifier can operate in large voltage range with V DD range from 2.5 to 4.2 V in mobile application. The total area of the amplifier is 1.7 mm2. Project supported by the National Natural Science Foundation of China (Nos. 61234002, 61322405, 61306044).

Implementation cost analysis of a community-based exercise program for seniors in South Florida.

PubMed

Page, Timothy F; Batra, Anamica; Ghouse, Muddasir M; Palmer, Richard C

2014-07-01

The objective of the study was to measure the costs of implementing the EnhanceFitness program to elderly residents of South Florida. The Health Foundation of South Florida's Healthy Aging Regional Collaborative implemented EnhanceFitness as part of their initiative to make evidence-based healthy aging programs available to South Florida seniors. Cost data were collected from agencies participating in the delivery of EnhanceFitness classes in South Florida. Cost questionnaires were e-mailed to program coordinators from agencies participating in the delivery of EnhanceFitness classes. Program coordinators worked with accounting staff to complete the questionnaires. Questionnaires were returned via e-mail. Costs were presented from the perspective of participating agencies. Total costs were divided by the number of classes being offered by each agency to determine cost per class per month. Average monthly costs per class were $1,713 during the first year of implementation and $873 during the second year of implementation. The cost measurements, combined with information from the literature on cost savings attributable to EnhanceFitness participation, suggest that EnhanceFitness has the potential to generate a net societal cost savings among program participants. The results are useful for community agencies considering implementing EnhanceFitness for their populations. © 2014 Society for Public Health Education.

Genome-wide identification and characterization of TCP transcription factor genes in upland cotton (Gossypium hirsutum).

PubMed

Li, Wen; Li, Deng-Di; Han, Li-Hong; Tao, Miao; Hu, Qian-Qian; Wu, Wen-Ying; Zhang, Jing-Bo; Li, Xue-Bao; Huang, Geng-Qing

2017-08-31

TCP proteins are plant-specific transcription factors (TFs), and perform a variety of physiological functions in plant growth and development. In this study, 74 non-redundant TCP genes were identified in upland cotton (Gossypium hirsutum L.) genome. Cotton TCP family can be classified into two classes (class I and class II) that can be further divided into 11 types (groups) based on their motif composition. Quantitative RT-PCR analysis indicated that GhTCPs display different expression patterns in cotton tissues. The majority of these genes are preferentially or specifically expressed in cotton leaves, while some GhTCP genes are highly expressed in initiating fibers and/or elongating fibers of cotton. Yeast two-hybrid results indicated that GhTCPs can interact with each other to form homodimers or heterodimers. In addition, GhTCP14a and GhTCP22 can interact with some transcription factors which are involved in fiber development. These results lay solid foundation for further study on the functions of TCP genes during cotton fiber development.

ASSOCIATIVE CONCEPT LEARNING IN ANIMALS

PubMed Central

Zentall, Thomas R.; Wasserman, Edward A.; Urcuioli, Peter J.

2014-01-01

Nonhuman animals show evidence for three types of concept learning: perceptual or similarity-based in which objects/stimuli are categorized based on physical similarity; relational in which one object/stimulus is categorized relative to another (e.g., same/different); and associative in which arbitrary stimuli become interchangeable with one another by virtue of a common association with another stimulus, outcome, or response. In this article, we focus on various methods for establishing associative concepts in nonhuman animals and evaluate data documenting the development of associative classes of stimuli. We also examine the nature of the common within-class representation of samples that have been associated with the same reinforced comparison response (i.e., many-to-one matching) by describing manipulations for distinguishing possible representations. Associative concepts provide one foundation for human language such that spoken and written words and the objects they represent become members of a class of interchangeable stimuli. The mechanisms of associative concept learning and the behavioral flexibility it allows, however, are also evident in the adaptive behaviors of animals lacking language. PMID:24170540

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs.

PubMed

Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E

2017-04-15

Class C G protein-coupled receptors (GPCRs) regulate important physiological functions and allosteric modulators binding to the transmembrane domain constitute an attractive and, due to a lack of structural insight, a virtually unexplored potential for therapeutics and the food industry. Combining pharmacological site-directed mutagenesis data with the recent class C GPCR experimental structures will provide a foundation for rational design of new therapeutics. We uncover one common site for both positive and negative modulators with different amino acid layouts that can be utilized to obtain selectivity. Additionally, we show a large potential for structure-based modulator design, especially for four orphan receptors with high similarity to the crystal structures. All collated mutagenesis data is available in the GPCRdb mutation browser at http://gpcrdb.org/mutations/ and can be analyzed online or downloaded in excel format. david.gloriam@sund.ku.dk. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Interoperability between biomedical ontologies through relation expansion, upper-level ontologies and automatic reasoning.

PubMed

Hoehndorf, Robert; Dumontier, Michel; Oellrich, Anika; Rebholz-Schuhmann, Dietrich; Schofield, Paul N; Gkoutos, Georgios V

2011-01-01

Researchers design ontologies as a means to accurately annotate and integrate experimental data across heterogeneous and disparate data- and knowledge bases. Formal ontologies make the semantics of terms and relations explicit such that automated reasoning can be used to verify the consistency of knowledge. However, many biomedical ontologies do not sufficiently formalize the semantics of their relations and are therefore limited with respect to automated reasoning for large scale data integration and knowledge discovery. We describe a method to improve automated reasoning over biomedical ontologies and identify several thousand contradictory class definitions. Our approach aligns terms in biomedical ontologies with foundational classes in a top-level ontology and formalizes composite relations as class expressions. We describe the semi-automated repair of contradictions and demonstrate expressive queries over interoperable ontologies. Our work forms an important cornerstone for data integration, automatic inference and knowledge discovery based on formal representations of knowledge. Our results and analysis software are available at http://bioonto.de/pmwiki.php/Main/ReasonableOntologies.

Xerostomia is associated with old age and poor appetite in patients on chronic hemodialysis.

PubMed

Bossola, Maurizio; Di Stasio, Enrico; Giungi, Stefania; Vulpio, Carlo; Papa, Valerio; Rosa, Fausto; Tortorelli, Antonio; Tazza, Luigi

2013-11-01

The objective of this study was to assess variables associated with xerostomia in patients on chronic hemodialysis (HD). This was a cross-sectional study of 75 HD patients at an outpatient HD service. Demographic, clinical (renal disease, HD regimen/duration, Charlson comorbidity index, activities of daily living, instrumental activities of daily living [IADL], body mass index), and laboratory (hemoglobin, albumin, interleukin-6 [IL-6], and parathyroid hormone) parameters were recorded. We assessed the appetite through the Hemodialysis Study Appetite questionnaire and xerostomia through the Xerostomia Inventory (XI). A single question ("How often does your mouth feel dry?"; never = Class 1, almost never = Class 2, occasionally = Class 3, often = Class 4, very often = Class 5) was also included in the study questionnaire. The main outcome measure was factors correlated with XI. The median XI score was 18 (min-max = 11-33). Forty patients had an XI score of 18 or less (Group 1) and between 18 and 35 (Group 2). In Group 2, age, Charlson comorbidity index score, and number of patients with poor/very poor appetite were significantly higher. At the univariate analysis, the score of the XI was significantly associated with age, appetite, IADL, Charlson comorbidity index, and serum IL-6 levels. Multiple linear regression analysis showed that the XI was independently associated with age and appetite. Thirty-one patients were in Class 1 to 2, 23 were in Class 3, and 21 were in Class 4 to 5. In Classes 4 to 5, age and the number of patients with poor/very poor appetite were higher (P = .012 and .09, respectively). Xerostomia is associated with old age and poor appetite in patients on chronic HD. Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Philosophical Foundations of Zwicky's Morphological Approach in Science

NASA Astrophysics Data System (ADS)

Rudnicki, Konrad

Fritz Zwicky as a conscious Goetheanist. Johann Wolfgang Goethe as a natural philosopher and methodologist. Goetheanist theory of knowledge — a theory essentially different from the theory of Kant, from which the contemporary concept of paradigms has originated. Pre-scientific character of theory of knowledge. The principal thought experiment. The role of thinking in Goetheanism. Fundamental phenomena. Morphological approach. The shape (µo ) of a problem. Morphological box. Individual hypothesis versus classes of hypotheses. Theory and reality.

Classical subjective expected utility.

PubMed

Cerreia-Vioglio, Simone; Maccheroni, Fabio; Marinacci, Massimo; Montrucchio, Luigi

2013-04-23

We consider decision makers who know that payoff-relevant observations are generated by a process that belongs to a given class M, as postulated in Wald [Wald A (1950) Statistical Decision Functions (Wiley, New York)]. We incorporate this Waldean piece of objective information within an otherwise subjective setting à la Savage [Savage LJ (1954) The Foundations of Statistics (Wiley, New York)] and show that this leads to a two-stage subjective expected utility model that accounts for both state and model uncertainty.

The MONET project and beyond

NASA Astrophysics Data System (ADS)

Hessma, F. V.

2004-10-01

The ``MOnitoring NEtwork of Telescopes'' (MONET) consists of two 1.2-m imaging telescopes funded by the Alfried Krupp von Bohlen und Halbach Foundation and the Georg-August-Universität Göttingen and will be operated by the McDonald Observatory in West Texas and the South African Astronomical Observatory at Sutherland. Scheduled to go into full operation in 2005, it will be used to perform a variety of monitoring and survey observations over the whole sky, to aid observations by satellites and 10m-class telescopes like the VLT, HET and SALT telescopes, and will be available to participating school classes all over the world. Through our development and use of Remote Telescope Markup Language (RTML), MONET should be one of the kernels of a growing international network of heterogeneous telescopes.

Bringing Real Solar Physics to the High School Classroom

NASA Astrophysics Data System (ADS)

Seaton, Daniel

2006-06-01

UNH's Partnership for Research Opportunities to Benefit Education (PROBE) project sends graduate students into high school classrooms across New Hampshire in order to help introduce students to authentic scientific inquiry. As one of ten graduate fellows, I worked with students in in ninth through twelfth grades in physical science, physics, earth science, and astronomy classes; helping students carry out individual and class projects on physics and solar physics. Projects related to solar physics included the production and analysis of plasma using a microwave oven, measurement of the solar constant, measurement of the solar rotation rate, solar spectroscopy, analysis of data from TRACE and SOHO, and the construction of various solar-powered devices. This work was generously supported by a grant from the National Science Foundation's GK-12 initiative (NSF#0338277).

Development of Residential SOFC Cogeneration System

NASA Astrophysics Data System (ADS)

Ono, Takashi; Miyachi, Itaru; Suzuki, Minoru; Higaki, Katsuki

2011-06-01

Since 2001 Kyocera has been developing 1kW class Solid Oxide Fuel Cell (SOFC) for power generation system. We have developed a cell, stack, module and system. Since 2004, Kyocera and Osaka Gas Co., Ltd. have been developed SOFC residential co-generation system. From 2007, we took part in the "Demonstrative Research on Solid Oxide Fuel Cells" Project conducted by New Energy Foundation (NEF). Total 57 units of 0.7kW class SOFC cogeneration systems had been installed at residential houses. In spite of residential small power demand, the actual electric efficiency was about 40%(netAC,LHV), and high CO2 reduction performance was achieved by these systems. Hereafter, new joint development, Osaka Gas, Toyota Motors, Kyocera and Aisin Seiki, aims early commercialization of residential SOFC CHP system.

Daredevils and early birds: Belgian pioneers in automobile racing and aerial sports during the belle époque.

PubMed

Ameye, Thomas; Gils, Bieke; Delheye, Pascal

2011-01-01

During the belle époque, Belgium was a trend-setting nation in many domains, including motorised sports. Belgian automobile racers and pilots shattered world records and became international stars. Striking was the shift in sports. Indeed, around 1896, sporting members of the leisure class stepped from the bicycle into the automobile and, around 1908, from the automobile into the airplane. Although these motorised sports were extremely expensive, this article shows that sportsmen and sportswomen from the working class could achieve upward social mobility through their performances. The achievements of these motorised pioneers had a major impact and wide-ranging significance. They laid the foundations for the expansion of the automobile industry and the emergence of civilian and military aviation.

Using the mixed media according to internet-based on the instructional multimedia for developing students' learning achievements in biology course on foundational cell issue of secondary students at the 10th grade level in Rangsit University demonstration school

NASA Astrophysics Data System (ADS)

Kangloan, Pichet; Chayaburakul, Kanokporn; Santiboon, Toansakul

2018-01-01

The aims of this research study were 1) to develop students' learning achievements in biology course on foundational cell issue, 2) to examine students' satisfactions of their learning activities through the mixed media according to internet-based multi-instruction in biology on foundational cell issue at the 10th grade level were used in the first semester in the academic year 2014, which a sample size of 17 students in Rangsit University Demonstration School with cluster random sampling was selected. Students' learning administrations were instructed with the 3-instructional lesson plans according to the 5-Step Ladder Learning Management Plan (LLMP) namely; the maintaining lesson plan on the equilibrium of cell issue, a lesson plan for learning how to communicate between cell and cell division. Students' learning achievements were assessed with the 30-item Assessment of Learning Biology Test (ALBT), students' perceptions of their satisfactions were satisfied with the 20-item Questionnaire on Students Satisfaction (QSS), and students' learning activities were assessed with the Mixed Media Internet-Based Instruction (MMIBI) on foundational cell issue was designed. The results of this research study have found that: statistically significant of students' post-learning achievements were higher than their pre-learning outcomes and indicated that the differences were significant at the .05 level. Students' performances of their satisfaction to their perceptions toward biology class with the mixed media according to internet-based multi instruction in biology on foundational cell issue were the highest level and evidence of average mean score as 4.59.

An innovative program to fund health-oriented student projects and research.

PubMed

Bybee, Ronald F; Thompson, Sharon E

2004-01-01

The price of a university education has increased over the years. As a result, students often graduate with thousands of dollars of debt. Conducting research or developing class projects that require personal expenditures can be overwhelming, if not impossible. Participation in research and in developing projects can enhance a student's educational experience. In an effort to address cost issues and provide an optimal learning experience for all students through participation in projects and research, the College of Health Sciences at the University of Texas at El Paso (UTEP) collaborated with a regional foundation to fund health-oriented students' projects and research. Approximately 100 projects have been funded in amounts from 200 dollars to 10,000 dollars at UTEP. Similar programs can be replicated at other US universities. Establishing a general fund and identifying contributors may be a viable option, although finding a foundation or agency to fund the project poses a challenge.

Socioeconomic variation, number competence, and mathematics learning difficulties in young children.

PubMed

Jordan, Nancy C; Levine, Susan C

2009-01-01

As a group, children from disadvantaged, low-income families perform substantially worse in mathematics than their counterparts from higher-income families. Minority children are disproportionately represented in low-income populations, resulting in significant racial and social-class disparities in mathematics learning linked to diminished learning opportunities. The consequences of poor mathematics achievement are serious for daily functioning and for career advancement. This article provides an overview of children's mathematics difficulties in relation to socioeconomic status (SES). We review foundations for early mathematics learning and key characteristics of mathematics learning difficulties. A particular focus is the delays or deficiencies in number competencies exhibited by low-income children entering school. Weaknesses in number competence can be reliably identified in early childhood, and there is good evidence that most children have the capacity to develop number competence that lays the foundation for later learning.

Life in the Universe: Foundation for exciting multidisciplinary science activities for middle and elementary school classes

NASA Technical Reports Server (NTRS)

Milne, D.; O'Sullivan, K.

1994-01-01

Young students find extra-terrestrial life one of the most intriguing of all topics. A project funded by the National Science Foundation and NASA, and administered by the SETI Institute, is underway to devise science lessons for grades 3-9 that draw upon this fascination. The lessons are designed by teachers and persons with long experience at curriculum design, tested in classrooms, revised and retested. Six guides, each containing some 6-10 science lessons, will be finished by summer, 1994.The theme Life in the Universe lends itself naturally to integrated treatment of facts and concepts from many scientific disciplines. The lessons for two completed guides span the origin of planet systems, evolution of complex life, chemical makeup of life, astronomy, spectroscopy, continental drift, mathematics and SETI (Search for Extra-Terrestrial Intelligence). All lessons are hands-on, interesting, and successful.

Life in the universe: foundation for exciting multidisciplinary science activities for middle and elementary school classes.

PubMed

Milne, D; O'Sullivan, K

1994-01-01

Young students find extra-terrestrial life one of the most intriguing of all topics. A project funded by the National Science Foundation and NASA, and administered by the SETI Institute, is underway to devise science lessons for grades 3-9 that draw upon this fascination. The lessons are designed by teachers and persons with long experience at curriculum design, tested in classrooms, revised and retested. Six guides, each containing some 6-10 science lessons, will be finished by summer, 1994. The theme Life in the Universe lends itself naturally to integrated treatment of facts and concepts from many scientific disciplines. The lessons for two completed guides span the origin of planet systems, evolution of complex life, chemical makeup of life, astronomy, spectroscopy, continental drift, mathematics and SETI (Search for Extra-Terrestrial Intelligence). All lessons are hands-on, interesting, and successful.

BOREAS TE-9 PAR and Leaf Nitrogen Data for NSA Species

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Dang, Qinglai; Margolis, Hank; Coyea, Marie

2000-01-01

The Boreal Ecosystem-Atmospheric Study (BOREAS) TE-9 (Terrestrial Ecology) team collected several data sets related to chemical and photosynthetic properties of leaves in boreal forest tree species. This data set describes the relationship between photosynthetically active radiation (PAR) levels and foliage nitrogen in samples from six sites in the BOREAS Northern Study Area (NSA) collected during the three 1994 intensive field campaigns (IFCs). This information is useful for modeling the vertical distribution of carbon fixation for these different forest types in the boreal forest. The data were collected to quantify the relationship between PAR and leaf nitrogen of black spruce, jack pine, and aspen. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Quality Control Test for Sequence-Phenotype Assignments

PubMed Central

Ortiz, Maria Teresa Lara; Rosario, Pablo Benjamín Leon; Luna-Nevarez, Pablo; Gamez, Alba Savin; Martínez-del Campo, Ana; Del Rio, Gabriel

2015-01-01

Relating a gene mutation to a phenotype is a common task in different disciplines such as protein biochemistry. In this endeavour, it is common to find false relationships arising from mutations introduced by cells that may be depurated using a phenotypic assay; yet, such phenotypic assays may introduce additional false relationships arising from experimental errors. Here we introduce the use of high-throughput DNA sequencers and statistical analysis aimed to identify incorrect DNA sequence-phenotype assignments and observed that 10–20% of these false assignments are expected in large screenings aimed to identify critical residues for protein function. We further show that this level of incorrect DNA sequence-phenotype assignments may significantly alter our understanding about the structure-function relationship of proteins. We have made available an implementation of our method at http://bis.ifc.unam.mx/en/software/chispas. PMID:25700273

Impedance Flow Cytometry as a Tool to Analyze Microspore and Pollen Quality.

PubMed

Heidmann, Iris; Di Berardino, Marco

2017-01-01

Analyzing pollen quality in an efficient and reliable manner is of great importance to the industries involved in seed and fruit production, plant breeding, and plant research. Pollen quality parameters, viability and germination capacity, are analyzed by various staining methods or by in vitro germination assays, respectively. These methods are time-consuming, species-dependent, and require a lab environment. Furthermore, the obtained viability data are often poorly related to in vivo pollen germination and seed set. Here, we describe a quick, label-free method to analyze pollen using microfluidic chips inserted into an impedance flow cytometer (IFC). Using this approach, pollen quality parameters are determined by a single measurement in a species-independent manner. The advantage of this protocol is that pollen viability and germination can be analyzed quickly by a reliable and standardized method.

BOREAS RSS-20 POLDER C-130 Measurements of Surface BRDF

NASA Technical Reports Server (NTRS)

Leroy, Marc; Hall, Forrest G. (Editor); Nickerson, Jaime (Editor); Smith, David E. (Technical Monitor)

2000-01-01

This Boreal Ecosystem-Atmosphere Study (BOREAS) Remote Sensing Science (RSS)-20 data set contains measurements of surface bidirectional reflectance distribution function (BRDF) made by the polarization and Directionality of Earth reflectances (POLDER) instrument over several surface types (pine, spruce, fen) of the BOREAS southern study area (SSA) during the 1994 intensive field campaigns (IFCs). Single-point BRDF values were acquired either from the NASA Ames Research Center (ARC) C-130 aircraft or from a NASA Wallops Flight Facility (WFF) helicopter. A related data set collected from the helicopter platform is available as is POLDER imagery acquired from the C-130. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884) or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Demonstration of a PC 25 Fuel Cell in Russia

DOE Office of Scientific and Technical Information (OSTI.GOV)

John C. Trocciola; Thomas N. Pompa; Linda S. Boyd

2004-09-01

This project involved the installation of a 200kW PC25C{trademark} phosphoric-acid fuel cell power plant at Orgenergogaz, a Gazprom industrial site in Russia. In April 1997, a PC25C{trademark} was sold by ONSI Corporation to Orgenergogaz, a subsidiary of the Russian company ''Gazprom''. Due to instabilities in the Russian financial markets, at that time, the unit was never installed and started by Orgenergogaz. In October of 2001 International Fuel Cells (IFC), now known as UTC Fuel Cells (UTCFC), received a financial assistance award from the United States Department of Energy (DOE) entitled ''Demonstration of PC 25 Fuel Cell in Russia''. Three majormore » tasks were part of this award: the inspection of the proposed site and system, start-up assistance, and installation and operation of the powerplant.« less

BOREAS TE-9 NSA Photosynthetic Response Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G.; Curd, Shelaine (Editor); Dang, Qinglai; Margolis, Hank; Coyea, Marie

2000-01-01

The Boreal Ecosystem-Atmospheric Study (BOREAS) TE-9 (Terrestrial Ecology) team collected several data sets related to chemical and photosynthetic properties of leaves. This data set describes: (1) the response of leaf and shoot-level photosynthesis to ambient and intercellular CO2 concentration, temperature, and incident photosynthetically active radiation (PAR) for black spruce, jack pine, and aspen during the three intensive field campaigns (IFCs) in 1994 in the Northern Study Area (NSA); (2) the response of stomatal conductance to vapor pressure difference throughout the growing season of 1994; and (3) a range of shoot water potentials (controlled in the laboratory) for black spruce and jack pine. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Findings from Five Years Investigating Science Literacy and Where Students Get their Information about Science

NASA Astrophysics Data System (ADS)

Buxner, Sanlyn; Impey, C. D.; Nieberding, M. N.; Romine, J. M.; Antonellis, J. C.; Llull, J.; Tijerino, K.; Collaborations of Astronomy Teaching Scholars (CATS)

2014-01-01

Supported by funding from NSF, we have been investigating the science literacy of undergraduate students using data collected from 1980 -2013. To date, we have collected over 12,000 surveys asking students about their foundational science knowledge as well as their attitudes towards science and technology topics. In 2012, we began investigating where students get their information about science and we have collected 30 interviews and almost 1000 survey responses. Our findings reveal that students’ science literacy, as measured by this instrument, has changed very little over the 23 years of data collection despite major educational innovations offered to students. A fraction of students continue to hold onto non-scientific beliefs, coupled with faith-based attitudes and beliefs, which are resistant to formal college instruction. Analysis of students’ open-ended responses show that although students use words often associated with science, they lack understandings of key aspects of science including the importance of evidence to support arguments and the need for replication of results. These results have important implications about how we teach science and how we assess students’ scientific understandings during class. Our recent work has shown that students use online sources to gain information about science for classes their own interests. Despite this, they rate professors and researchers as more reliable sources of scientific knowledge than online sources. This disconnect raises questions about how educators can work with students to provide knowledge in ways that are both accessible and reliable and how to help students sort knowledge in an age where everything can be found online. This material is based in part upon work supported by the National Science Foundation under Grant No. 0715517, a CCLI Phase III Grant for the Collaboration of Astronomy Teaching Scholars (CATS). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

Vegetation fire proneness in Europe

NASA Astrophysics Data System (ADS)

Pereira, Mário; Aranha, José; Amraoui, Malik

2015-04-01

Fire selectivity has been studied for vegetation classes in terms of fire frequency and fire size in a few European regions. This analysis is often performed along with other landscape variables such as topography, distance to roads and towns. These studies aims to assess the landscape sensitivity to forest fires in peri-urban areas and land cover changes, to define landscape management guidelines and policies based on the relationships between landscape and fires in the Mediterranean region. Therefore, the objectives of this study includes the: (i) analysis of the spatial and temporal variability statistics within Europe; and, (ii) the identification and characterization of the vegetated land cover classes affected by fires; and, (iii) to propose a fire proneness index. The datasets used in the present study comprises: Corine Land Cover (CLC) maps for 2000 and 2006 (CLC2000, CLC2006) and burned area (BA) perimeters, from 2000 to 2013 in Europe, provided by the European Forest Fire Information System (EFFIS). The CLC is a part of the European Commission programme to COoRdinate INformation on the Environment (Corine) and it provides consistent, reliable and comparable information on land cover across Europe. Both the CLC and EFFIS datasets were combined using geostatistics and Geographical Information System (GIS) techniques to access the spatial and temporal evolution of the types of shrubs and forest affected by fires. Obtained results confirms the usefulness and efficiency of the land cover classification scheme and fire proneness index which allows to quantify and to compare the propensity of vegetation classes and countries to fire. As expected, differences between northern and southern Europe are notorious in what concern to land cover distribution, fire incidence and fire proneness of vegetation cover classes. This work was supported by national funds by FCT - Portuguese Foundation for Science and Technology, under the project PEst-OE/AGR/UI4033/2014 and by the project SUSTAINSYS: Environmental Sustainable Agro-Forestry Systems (NORTE-07-0124-FEDER-000044), financed by the North Portugal Regional Operational Programme (ON.2 - O Novo Norte), under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), as well as by National Funds (PIDDAC) through the Portuguese Foundation for Science and Technology (FCT/MEC).

Some theoretical issues on computer simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barrett, C.L.; Reidys, C.M.

1998-02-01

The subject of this paper is the development of mathematical foundations for a theory of simulation. Sequentially updated cellular automata (sCA) over arbitrary graphs are employed as a paradigmatic framework. In the development of the theory, the authors focus on the properties of causal dependencies among local mappings in a simulation. The main object of and study is the mapping between a graph representing the dependencies among entities of a simulation and a representing the equivalence classes of systems obtained by all possible updates.

Sea King SHOL Support for Post-HCM/FELEX HALIFAX Class Ships

DTIC Science & Technology

2014-05-01

correct this, a Network Time Protocol (NTP) time server was installed on two Raspberry - Pi computers3 (one used as a backup). Time was set to GPS time...data is needed, a wave buoy would be deployed for direct measurement. However, the launch & recovery of a 3The Raspberry Pi is an inexpensive credit...card-sized single-board computer developed in the UK by the Raspberry Pi Foundation. DRDC-RDDC-2014-R18 15 wave buoy was not practical in conjunction

KSC-2012-2725

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, space shuttle astronaut and U.S. Astronaut Hall of Fame Class of 2012 inductee Franklin Chang Diaz, at the podium, speaks during the induction ceremony. Shuttle astronauts Kevin Chilton and Charlie Precourt also were inducted into the Hall of Fame. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

KSC-2012-2732

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, shuttle astronaut Charlie Precourt speaks after being inducted into the U.S. Astronaut Hall of Fame Class of 2012. Shuttle astronauts Franklin Chang Diaz and Kevin Chilton also were inducted into the Hall of Fame. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann

KSC-2012-2727

NASA Image and Video Library

2012-05-05

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, shuttle astronaut Kevin Chilton speaks after being inducted into the U.S. Astronaut Hall of Fame Class of 2012. Shuttle astronauts Franklin Chang Diaz and Charlie Precourt also were inducted into the Hall of Fame. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. Photo credit: NASA/Jim Grossmann