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Sample records for four-fermion interaction models

  1. Conformal window of gauge theories with four-fermion interactions and ideal walking technicolor

    NASA Astrophysics Data System (ADS)

    Fukano, Hidenori S.; Sannino, Francesco

    2010-08-01

    We investigate the effects of four-fermion interactions on the phase diagram of strongly interacting theories for any representation as function of the number of colors and flavors. We show that the conformal window, for any representation, shrinks with respect to the case in which the four-fermion interactions are neglected. The anomalous dimension of the mass increases beyond the unity value at the lower boundary of the new conformal window. We plot the new phase diagram which can be used, together with the information about the anomalous dimension, to propose ideal models of walking technicolor. We discover that when the extended technicolor sector, responsible for giving masses to the standard model fermions, is sufficiently strongly coupled the technicolor theory, in isolation, must have an infrared fixed point for the full model to be phenomenologically viable. Using the new phase diagram we show that the simplest one family and minimal walking technicolor models are the archetypes of models of dynamical electroweak symmetry breaking. Our predictions can be verified via first principle lattice simulations.

  2. Gravity-Induced Four-Fermion Contact Interaction Implies Gravitational Intermediate W and Z Type Gauge Bosons

    NASA Astrophysics Data System (ADS)

    Boos, Jens; Hehl, Friedrich W.

    2017-03-01

    Coupling fermions to gravity necessarily leads to a non-renormalizable, gravitational four-fermion contact interaction. In this essay, we argue that augmenting the Einstein-Cartan Lagrangian with suitable kinetic terms quadratic in the gravitational gauge field strengths (torsion and curvature) gives rise to new, massive propagating gravitational degrees of freedom. This is to be seen in close analogy to Fermi's effective four-fermion interaction and its emergent W and Z bosons.

  3. Non-perturbative scale evolution of four-fermion operators in two-flavour QCD

    NASA Astrophysics Data System (ADS)

    Herdoiza, Gregorio

    2006-12-01

    We apply finite-size recursion techniques based on the Schrödinger functional formalism to de- termine the renormalization group running of four-fermion operators which appear in the S = 2 effective weak Hamiltonian of the Standard Model. Our calculations are done using O(a) im- proved Wilson fermions with Nf = 2 dynamical flavours. Preliminary results are presented for the four-fermion operator which determines the BK -parameter in tmQCD.

  4. One-loop corrections to h → boverline{b} and h → τ overline{τ} decays in the Standard Model dimension-6 EFT: four-fermion operators and the large- m t limit

    NASA Astrophysics Data System (ADS)

    Gauld, Rhorry; Pecjak, Benjamin D.; Scott, Darren J.

    2016-05-01

    We calculate a set of one-loop corrections to h → boverline{b} and h → τ overline{τ} decays in the dimension-6 Standard Model effective field theory (SMEFT). In particular, working in the limit of vanishing gauge couplings, we calculate directly in the broken phase of the theory all large logarithmic corrections and in addition the finite corrections in the large- m t limit. Moreover, we give exact results for one-loop contributions from four-fermion operators. We obtain these corrections within an extension of the widely used on-shell renormalisation scheme appropriate for SMEFT calculations, and show explicitly how UV divergent bare amplitudes from a total of 21 different SMEFT operators are rendered finite within this scheme. As a by-product of the calculation, we also compute to one-loop order the logarithmically enhanced and finite large- m t corrections to muon decay in the limit of vanishing gauge couplings, which is necessary to implement the G F input parameter scheme within the SMEFT.

  5. Impact of a Higgs boson at a mass of 126 GeV on the standard model with three and four fermion generations.

    PubMed

    Eberhardt, Otto; Herbert, Geoffrey; Lacker, Heiko; Lenz, Alexander; Menzel, Andreas; Nierste, Ulrich; Wiebusch, Martin

    2012-12-14

    We perform a comprehensive statistical analysis of the standard model (SM) with three and four generations using the latest Higgs search results from LHC and Tevatron, the electroweak precision observables measured at LEP and SLD, and the latest determinations of M(W), m(t), and α(s). For the three-generation case we analyze the tensions in the electroweak fit by removing individual observables from the fit and comparing their predicted values with the measured ones. In particular, we discuss the impact of the Higgs search results on the deviations of the electroweak precision observables from their best-fit values. Our indirect prediction of the top mass is m(t) =175.7(-2.2)(+3.0) GeV at 68.3% C.L., which is in good agreement with the direct measurement. We also plot the preferred area in the M(W)-m(t) plane. The best-fit Higgs boson mass is 126.0 GeV. For the case of the SM with a perturbative sequential fourth fermion generation (SM4) we discuss the deviations of the Higgs signal strengths from their best-fit values. The H → γγ signal strength now disagrees with its best-fit SM4 value at more than 4σ. We perform a likelihood-ratio test to compare the SM and SM4 and show that the SM4 is excluded at 5.3σ. Without the Tevatron data on H → bb the significance drops to 4.8σ.

  6. Perturbative matching of the staggered four-fermion operators for {epsilon}'/{epsilon}

    SciTech Connect

    Lee, Weonjong

    2001-09-01

    Using staggered fermions, we calculate the perturbative corrections to the bilinear and four-fermion operators that are used in the numerical study of weak matrix elements for {epsilon}'/{epsilon}. We present results for one-loop matching coefficients between continuum operators, calculated in the naive dimensional regularization (NDR) scheme, and gauge invariant staggered fermion operators. In particular, we concentrate on Feynman diagrams of the current-current insertion type. We also present results for the tadpole improved operators. These results, combined with existing results for penguin diagrams, provide a complete one-loop renormalization of the staggered four-fermion operators. Therefore, using our results, it is possible to match a lattice calculation of K{sup 0}-{bar K}{sup 0} mixing and K{yields}{pi}{pi} decays to the continuum NDR results with all corrections of O(g{sup 2}) included.

  7. Four-fermion production at γ γ colliders: 1. Lowest-order predictions and anomalous couplings

    NASA Astrophysics Data System (ADS)

    Bredenstein, A.; Dittmaier, S.; Roth, M.

    2004-08-01

    We have constructed a Monte Carlo generator (the corresponding FORTRAN code can be obtained from the authors upon request) for lowest-order predictions for the processes γγto 4f and γγto 4fγ in the standard model and extensions thereof by an effective γγ H coupling as well as anomalous triple and quartic gauge-boson couplings. Polarization is fully supported, and a realistic photon beam spectrum can be taken into account. For the processes γγto 4f all helicity amplitudes are explicitly given in a compact form. The presented numerical results contain, in particular, a survey of cross sections for representative final states and their comparison to results obtained with the program package Whizard/Madgraph. The impact of a realistic beam spectrum on cross sections and distributions is illustrated. Moreover, the size of various contributions to cross sections, such as from weak charged- or neutral-current, or from strong interactions, is analyzed. Particular attention is paid to W-pair production channels γγto W Wto 4f(γ) where we investigate the impact of background diagrams, possible definitions of the W-pair signal, and the issue of gauge-invariance violation caused by finite gauge-boson widths. Finally, the effects of triple and quartic anomalous gauge-boson couplings on cross sections as well as the possibility to constrain these anomalous couplings at future γγ colliders are discussed.

  8. Perturbative renormalization factors and O(a{sup 2}) corrections for lattice four-fermion operators with improved fermion/gluon actions

    SciTech Connect

    Constantinou, Martha; Panagopoulos, Haralambos; Skouroupathis, Apostolos; Stylianou, Fotos; Dimopoulos, Petros; Frezzotti, Roberto

    2011-04-01

    In this work we calculate the corrections to the amputated Green's functions of four-fermion operators, in 1-loop lattice perturbation theory. One of the novel aspects of our calculations is that they are carried out to second order in the lattice spacing, O(a{sup 2}). We employ the Wilson/clover action for massless fermions (also applicable for the twisted mass action in the chiral limit) and a family of Symanzik improved actions for gluons. Our calculations have been carried out in a general covariant gauge. Results have been obtained for several popular choices of values for the Symanzik coefficients (Plaquette, Tree-level Symanzik, Iwasaki, TILW and DBW2 action). While our Green's function calculations regard any pointlike four-fermion operators which do not mix with lower dimension ones, we pay particular attention to {Delta}F=2 operators, both parity conserving and parity violating (F stands for flavor: S, C, B). By appropriately projecting those bare Green's functions we compute the perturbative renormalization constants for a complete basis of four-fermion operators and we study their mixing pattern. For some of the actions considered here, even O(a{sup 0}) results did not exist in the literature to date. The correction terms which we calculate (along with our previous O(a{sup 2}) calculation of Z{sub {Psi}}[M. Constantinou, V. Lubicz, H. Panagopoulos, and F. Stylianou, J. High Energy Phys. 10 (2009) 064.][M. Constantinou, P. Dimopoulos, R. Frezzotti, G. Herdoiza, K. Jansen, V. Lubicz, H. Panagopoulos, G. C. Rossi, S. Simula, F. Stylianou, and A. Vladikas, J. High Energy Phys. 08 (2010) 068.][C. Alexandrou, M. Constantinou, T. Korzec, H. Panagopoulos, and F. Stylianou (unpublished).]) are essential ingredients for minimizing the lattice artifacts which are present in nonperturbative evaluations of renormalization constants with the RI{sup '}-MOM method. Our perturbative results, for the matrix elements of {Delta}F=2 operators and for the corresponding

  9. Latent Variable Interaction Modeling.

    ERIC Educational Resources Information Center

    Schumacker, Randall E.

    2002-01-01

    Used simulation to study two different approaches to latent variable interaction modeling with continuous observed variables: (1) a LISREL 8.30 program and (2) data analysis through PRELIS2 and SIMPLIS programs. Results show that parameter estimation was similar but standard errors were different. Discusses differences in ease of implementation.…

  10. JSPAM: Interacting galaxies modeller

    NASA Astrophysics Data System (ADS)

    Wallin, John F.; Holincheck, Anthony; Harvey, Allen

    2015-11-01

    JSPAM models galaxy collisions using a restricted n-body approach to speed up computation. Instead of using a softened point-mass potential, the software supports a modified version of the three component potential created by Hernquist (1994, ApJS 86, 389). Although spherically symmetric gravitationally potentials and a Gaussian model for the bulge are used to increase computational efficiency, the potential mimics that of a fully consistent n-body model of a galaxy. Dynamical friction has been implemented in the code to improve the accuracy of close approaches between galaxies. Simulations using this code using thousands of particles over the typical interaction times of a galaxy interaction take a few seconds on modern desktop workstations, making it ideal for rapidly prototyping the dynamics of colliding galaxies. Extensive testing of the code has shown that it produces nearly identical tidal features to those from hierarchical tree codes such as Gadget but using a fraction of the computational resources. This code was used in the Galaxy Zoo: Mergers project and is very well suited for automated fitting of galaxy mergers with automated pattern fitting approaches such as genetic algorithms. Java and Fortran versions of the code are available.

  11. Digital quantum simulation of fermionic models with a superconducting circuit

    PubMed Central

    Barends, R.; Lamata, L.; Kelly, J.; García-Álvarez, L.; Fowler, A. G.; Megrant, A; Jeffrey, E; White, T. C.; Sank, D.; Mutus, J. Y.; Campbell, B.; Chen, Yu; Chen, Z.; Chiaro, B.; Dunsworth, A.; Hoi, I.-C.; Neill, C.; O'Malley, P. J. J.; Quintana, C.; Roushan, P.; Vainsencher, A.; Wenner, J.; Solano, E.; Martinis, John M.

    2015-01-01

    One of the key applications of quantum information is simulating nature. Fermions are ubiquitous in nature, appearing in condensed matter systems, chemistry and high energy physics. However, universally simulating their interactions is arguably one of the largest challenges, because of the difficulties arising from anticommutativity. Here we use digital methods to construct the required arbitrary interactions, and perform quantum simulation of up to four fermionic modes with a superconducting quantum circuit. We employ in excess of 300 quantum logic gates, and reach fidelities that are consistent with a simple model of uncorrelated errors. The presented approach is in principle scalable to a larger number of modes, and arbitrary spatial dimensions. PMID:26153660

  12. Digital quantum simulation of fermionic models with a superconducting circuit

    NASA Astrophysics Data System (ADS)

    Barends, R.; Lamata, L.; Kelly, J.; García-Álvarez, L.; Fowler, A. G.; Megrant, A.; Jeffrey, E.; White, T. C.; Sank, D.; Mutus, J. Y.; Campbell, B.; Chen, Yu; Chen, Z.; Chiaro, B.; Dunsworth, A.; Hoi, I.-C.; Neill, C.; O'Malley, P. J. J.; Quintana, C.; Roushan, P.; Vainsencher, A.; Wenner, J.; Solano, E.; Martinis, John M.

    2015-07-01

    One of the key applications of quantum information is simulating nature. Fermions are ubiquitous in nature, appearing in condensed matter systems, chemistry and high energy physics. However, universally simulating their interactions is arguably one of the largest challenges, because of the difficulties arising from anticommutativity. Here we use digital methods to construct the required arbitrary interactions, and perform quantum simulation of up to four fermionic modes with a superconducting quantum circuit. We employ in excess of 300 quantum logic gates, and reach fidelities that are consistent with a simple model of uncorrelated errors. The presented approach is in principle scalable to a larger number of modes, and arbitrary spatial dimensions.

  13. Mental Models in Social Interaction

    ERIC Educational Resources Information Center

    Fernandez-Berrocal, Pablo; Santamaria, Carlos

    2006-01-01

    In this study, the authors introduce a new way to analyze cognitive change during social interactions, based on the mental model theory of reasoning. From this approach, cognitive performance can be improved for solving problems that require multiple models when participants in a social interaction group maintain qualitatively different models of…

  14. Interaction Models for Functional Regression

    PubMed Central

    USSET, JOSEPH; STAICU, ANA-MARIA; MAITY, ARNAB

    2015-01-01

    A functional regression model with a scalar response and multiple functional predictors is proposed that accommodates two-way interactions in addition to their main effects. The proposed estimation procedure models the main effects using penalized regression splines, and the interaction effect by a tensor product basis. Extensions to generalized linear models and data observed on sparse grids or with measurement error are presented. A hypothesis testing procedure for the functional interaction effect is described. The proposed method can be easily implemented through existing software. Numerical studies show that fitting an additive model in the presence of interaction leads to both poor estimation performance and lost prediction power, while fitting an interaction model where there is in fact no interaction leads to negligible losses. The methodology is illustrated on the AneuRisk65 study data. PMID:26744549

  15. Modeling Interactive Intelligences

    DTIC Science & Technology

    2002-08-01

    New York: Basic Books, 1999. P. 207-10. [5] Piaget , Jean . Play, Dreams, and Imitation in Childhood. New York: Norton, 1962. [6] Dillard, Annie. Living...concepts of reentry and binding. Next, I rely on Jean Piaget’s model of adaptation in order to examine the function of imitation and play in an...rather than metrics should be used. 2. ADAPTATION, SELECTION, IMITATION, AND PLAY Piaget presented adaptive behavior as a combination of accommodation and

  16. The joy of interactive modeling

    NASA Astrophysics Data System (ADS)

    Donchyts, Gennadii; Baart, Fedor; van Dam, Arthur; Jagers, Bert

    2013-04-01

    The conventional way of working with hydrodynamical models usually consists of the following steps: 1) define a schematization (e.g., in a graphical user interface, or by editing input files) 2) run model from start to end 3) visualize results 4) repeat any of the previous steps. This cycle commonly takes up from hours to several days. What if we can make this happen instantly? As most of the research done using numerical models is in fact qualitative and exploratory (Oreskes et al., 1994), why not use these models as such? How can we adapt models so that we can edit model input, run and visualize results at the same time? More and more, interactive models become available as online apps, mainly for demonstration and educational purposes. These models often simplify the physics behind flows and run on simplified model geometries, particularly when compared with state-of-the-art scientific simulation packages. Here we show how the aforementioned conventional standalone models ("static, run once") can be transformed into interactive models. The basic concepts behind turning existing (conventional) model engines into interactive engines are the following. The engine does not run the model from start to end, but is always available in memory, and can be fed by new boundary conditions, or state changes at any time. The model can be run continuously, per step, or up to a specified time. The Hollywood principle dictates how the model engine is instructed from 'outside', instead of the model engine taking all necessary actions on its own initiative. The underlying techniques that facilitate these concepts are introspection of the computation engine, which exposes its state variables, and control functions, e.g. for time stepping, via a standardized interface, such as BMI (Peckam et. al., 2012). In this work we have used a shallow water flow model engine D-Flow Flexible Mesh. The model was converted from executable to a library, and coupled to the graphical modelling

  17. Interactive modeling of storm impact

    NASA Astrophysics Data System (ADS)

    van Rooijen, A.; Baart, F.; Roelvink, J. A.; Donchyts, G.; Scheel, F.; de Boer, W.

    2014-12-01

    In the past decades the impact of storms on the coastal zone has increasingly drawn the attention of policy makers and coastal planners, engineers and researchers. The mean reason for this interest is the high density of the world's population living near the ocean, in combination with climate change. Due to sea level rise and extremer weather conditions, many of the world's coastlines are becoming more vulnerable to the potential of flooding. Currently it is common practice to predict storm impact using physics-based numerical models. The numerical model utilizes several inputs (e.g. bathymetry, waves, surge) to calculate the impact on the coastline. Traditionally, the numerical modeller takes the following three steps: schematization/model setup, running and post-processing. This process generally has a total feedback time in the order of hours to days, and is suitable for so-called confirmatory modelling.However, often models are applied as an exploratory tool, in which the effect of e.g. different hydraulic conditions, or measures is investigated. The above described traditional work flow is not the most efficient method for exploratory modelling. Interactive modelling lets users adjust a simulation while running. For models typically used for storm impact studies (e.g. XBeach, Delft3D, D-Flow FM), the user can for instance change the storm surge level, wave conditions, or add a measure such as a nourishment or a seawall. The model will take the adjustments into account immediately, and will directly compute the effect. Using this method, tools can be developed in which stakeholders (e.g. coastal planners, policy makers) are in control and together evaluate ideas by interacting with the model. Here we will show initial results for interactive modelling with a storm impact model.

  18. Modeling Interactions in Small Groups

    ERIC Educational Resources Information Center

    Heise, David R.

    2013-01-01

    A new theory of interaction within small groups posits that group members initiate actions when tension mounts between the affective meanings of their situational identities and impressions produced by recent events. Actors choose partners and behaviors so as to reduce the tensions. A computer model based on this theory, incorporating reciprocal…

  19. Models of dyadic social interaction.

    PubMed Central

    Griffin, Dale; Gonzalez, Richard

    2003-01-01

    We discuss the logic of research designs for dyadic interaction and present statistical models with parameters that are tied to psychologically relevant constructs. Building on Karl Pearson's classic nineteenth-century statistical analysis of within-organism similarity, we describe several approaches to indexing dyadic interdependence and provide graphical methods for visualizing dyadic data. We also describe several statistical and conceptual solutions to the 'levels of analytic' problem in analysing dyadic data. These analytic strategies allow the researcher to examine and measure psychological questions of interdependence and social influence. We provide illustrative data from casually interacting and romantic dyads. PMID:12689382

  20. Fermion pair production in e+e- collisions at 189 209 GeV and constraints on physics beyond the standard model

    NASA Astrophysics Data System (ADS)

    Schael, S.; Barate, R.; Brunelière, R.; de Bonis, I.; Decamp, D.; Goy, C.; Jézéquel, S.; Lees, J.-P.; Martin, F.; Merle, E.; Minard, M.-N.; Pietrzyk, B.; Trocmé, B.; Bravo, S.; Casado, M. P.; Chmeissani, M.; Crespo, J. M.; Fernandez, E.; Fernandez-Bosman, M.; Garrido, L.; Martinez, M.; Pacheco, A.; Ruiz, H.; Colaleo, A.; Creanza, D.; de Filippis, N.; de Palma, M.; Iaselli, G.; Maggi, G.; Maggi, M.; Nuzzo, S.; Ranieri, A.; Raso, G.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Tricomi, A.; Zito, G.; Huang, X.; Lin, J.; Ouyang, Q.; Wang, T.; Xie, Y.; Xu, R.; Xue, S.; Zhang, J.; Zhang, L.; Zhao, W.; Abbaneo, D.; Barklow, T.; Buchmüller, O.; Cattaneo, M.; Clerbaux, B.; Drevermann, H.; Forty, R. W.; Frank, M.; Gianotti, F.; Hansen, J. B.; Harvey, J.; Hutchcroft, D. E.; Janot, P.; Jost, B.; Kado, M.; Mato, P.; Moutoussi, A.; Ranjard, F.; Rolandi, L.; Schlatter, D.; Teubert, F.; Valassi, A.; Videau, I.; Badaud, F.; Dessagne, S.; Falvard, A.; Fayolle, D.; Gay, P.; Jousset, J.; Michel, B.; Monteil, S.; Pallin, D.; Pascolo, J. M.; Perret, P.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Kraan, A. C.; Nilsson, B. S.; Kyriakis, A.; Markou, C.; Simopoulou, E.; Vayaki, A.; Zachariadou, K.; Blondel, A.; Brient, J.-C.; Machefert, F.; Rougé, A.; Videau, H.; Ciulli, V.; Focardi, E.; Parrini, G.; Antonelli, A.; Antonelli, M.; Bencivenni, G.; Bossi, F.; Capon, G.; Cerutti, F.; Chiarella, V.; Laurelli, P.; Mannocchi, G.; Murtas, G. P.; Passalacqua, L.; Kennedy, J.; Lynch, J. G.; Negus, P.; O'Shea, V.; Thompson, A. S.; Wasserbaech, S.; Cavanaugh, R.; Dhamotharan, S.; Geweniger, C.; Hanke, P.; Hepp, V.; Kluge, E. E.; Putzer, A.; Stenzel, H.; Tittel, K.; Wunsch, M.; Beuselinck, R.; Cameron, W.; Davies, G.; Dornan, P. J.; Girone, M.; Hill, R. D.; Marinelli, N.; Nowell, J.; Rutherford, S. A.; Sedgbeer, J. K.; Thompson, J. C.; White, R.; Ghete, V. M.; Girtler, P.; Kneringer, E.; Kuhn, D.; Rudolph, G.; Bouhova-Thacker, E.; Bowdery, C. K.; Clarke, D. P.; Ellis, G.; Finch, A. J.; Foster, F.; Hughes, G.; Jones, R. W. L.; Pearson, M. R.; Robertson, N. A.; Smizanska, M.; van der Aa, O.; Delaere, C.; Leibenguth, G.; Lemaitre, V.; Blumenschein, U.; Hölldorfer, F.; Jakobs, K.; Kayser, F.; Müller, A.-S.; Quast, G.; Renk, B.; Sander, H.-G.; Schmeling, S.; Wachsmuth, H.; Zeitnitz, C.; Ziegler, T.; Bonissent, A.; Coyle, P.; Curtil, C.; Ealet, A.; Fouchez, D.; Payre, P.; Tilquin, A.; Ragusa, F.; David, A.; Dietl, H.; Ganis, G.; Hüttmann, K.; Lütjens, G.; Männer, W.; Moser, H.-G.; Settles, R.; Villegas, M.; Wolf, G.; Boucrot, J.; Callot, O.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, P.; Jacholkowska, A.; Serin, L.; Veillet, J.-J.; Azzurri, P.; Bagliesi, G.; Boccali, T.; Foà, L.; Giammanco, A.; Giassi, A.; Ligabue, F.; Messineo, A.; Palla, F.; Sanguinetti, G.; Sciabà, A.; Sguazzoni, G.; Spagnolo, P.; Tenchini, R.; Venturi, A.; Verdini, P. G.; Awunor, O.; Blair, G. A.; Cowan, G.; Garcia-Bellido, A.; Green, M. G.; Medcalf, T.; Misiejuk, A.; Strong, J. A.; Teixeira-Dias, P.; Clifft, R. W.; Edgecock, T. R.; Norton, P. R.; Tomalin, I. R.; Ward, J. J.; Bloch-Devaux, B.; Boumediene, D.; Colas, P.; Fabbro, B.; Lançon, E.; Lemaire, M.-C.; Locci, E.; Perez, P.; Rander, J.; Tuchming, B.; Vallage, B.; Litke, A. M.; Taylor, G.; Booth, C. N.; Cartwright, S.; Combley, F.; Hodgson, P. N.; Lehto, M.; Thompson, L. F.; Böhrer, A.; Brandt, S.; Grupen, C.; Hess, J.; Ngac, A.; Prange, G.; Borean, C.; Giannini, G.; He, H.; Putz, J.; Rothberg, J.; Armstrong, S. R.; Berkelman, K.; Cranmer, K.; Ferguson, D. P. S.; Gao, Y.; González, S.; Hayes, O. J.; Hu, H.; Jin, S.; Kile, J.; McNamara, P. A., III; Nielsen, J.; Pan, Y. B.; von Wimmersperg-Toeller, J. H.; Wiedenmann, W.; Wu, J.; Wu, Sau Lan; Wu, X.; Zobernig, G.; Dissertori, G.

    2007-01-01

    Cross sections, angular distributions and forward-backward asymmetries are presented, of two-fermion events produced in e+e- collisions at centre-of-mass energies from 189 to 209 GeV at LEP, measured with the ALEPH detector. Results for e+e-, μ+μ-, τ+τ-, qq¯, bb¯ and cc¯ production are in agreement with the standard model predictions. Constraints are set on scenarios of new physics such as four-fermion contact interactions, leptoquarks, Z‧ bosons, TeV-scale quantum gravity and R-parity violating squarks and sneutrinos.

  1. Anisotropic exchange-interaction model: From the Potts model to the exchange-interaction model

    NASA Astrophysics Data System (ADS)

    King, T. C.; Chen, H. H.

    1995-04-01

    A spin model called the anisotropic exchange-interaction model is proposed. The Potts model, the exchange-interaction model, and the spin-1/2 anisotropic Heisenberg model are special cases of the proposed model. Thermodynamic properties of the model on the bcc and the fcc lattices are determined by the constant-coupling approximation.

  2. Stochastic hyperfine interactions modeling library

    NASA Astrophysics Data System (ADS)

    Zacate, Matthew O.; Evenson, William E.

    2011-04-01

    The stochastic hyperfine interactions modeling library (SHIML) provides a set of routines to assist in the development and application of stochastic models of hyperfine interactions. The library provides routines written in the C programming language that (1) read a text description of a model for fluctuating hyperfine fields, (2) set up the Blume matrix, upon which the evolution operator of the system depends, and (3) find the eigenvalues and eigenvectors of the Blume matrix so that theoretical spectra of experimental techniques that measure hyperfine interactions can be calculated. The optimized vector and matrix operations of the BLAS and LAPACK libraries are utilized; however, there was a need to develop supplementary code to find an orthonormal set of (left and right) eigenvectors of complex, non-Hermitian matrices. In addition, example code is provided to illustrate the use of SHIML to generate perturbed angular correlation spectra for the special case of polycrystalline samples when anisotropy terms of higher order than A can be neglected. Program summaryProgram title: SHIML Catalogue identifier: AEIF_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEIF_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU GPL 3 No. of lines in distributed program, including test data, etc.: 8224 No. of bytes in distributed program, including test data, etc.: 312 348 Distribution format: tar.gz Programming language: C Computer: Any Operating system: LINUX, OS X RAM: Varies Classification: 7.4 External routines: TAPP [1], BLAS [2], a C-interface to BLAS [3], and LAPACK [4] Nature of problem: In condensed matter systems, hyperfine methods such as nuclear magnetic resonance (NMR), Mössbauer effect (ME), muon spin rotation (μSR), and perturbed angular correlation spectroscopy (PAC) measure electronic and magnetic structure within Angstroms of nuclear probes through the hyperfine interaction. When

  3. Hierarchical modeling of protein interactions.

    PubMed

    Kurcinski, Mateusz; Kolinski, Andrzej

    2007-07-01

    A novel approach to hierarchical peptide-protein and protein-protein docking is described and evaluated. Modeling procedure starts from a reduced space representation of proteins and peptides. Polypeptide chains are represented by strings of alpha-carbon beads restricted to a fine-mesh cubic lattice. Side chains are represented by up to two centers of interactions, corresponding to beta-carbons and the centers of mass of the remaining portions of the side groups, respectively. Additional pseudoatoms are located in the centers of the virtual bonds connecting consecutive alpha carbons. These pseudoatoms support a model of main-chain hydrogen bonds. Docking starts from a collection of random configurations of modeled molecules. Interacting molecules are flexible; however, higher accuracy models are obtained when the conformational freedom of one (the larger one) of the assembling molecules is limited by a set of weak distance restraints extracted from the experimental (or theoretically predicted) structures. Sampling is done by means of Replica Exchange Monte Carlo method. Afterwards, the set of obtained structures is subject to a hierarchical clustering. Then, the centroids of the resulting clusters are used as scaffolds for the reconstruction of the atomic details. Finally, the all-atom models are energy minimized and scored using classical tools of molecular mechanics. The method is tested on a set of macromolecular assemblies consisting of proteins and peptides. It is demonstrated that the proposed approach to the flexible docking could be successfully applied to prediction of protein-peptide and protein-protein interactions. The obtained models are almost always qualitatively correct, although usually of relatively low (or moderate) resolution. In spite of this limitation, the proposed method opens new possibilities of computational studies of macromolecular recognition and mechanisms of assembly of macromolecular complexes.

  4. Wave/current interaction model

    NASA Technical Reports Server (NTRS)

    Liu, A. K.

    1988-01-01

    The wave-current interaction for the application to remote sensing data via numerical simulations and data comparison is modelled. Using the field data of surface current shear, wind condition and ambient wave spectrum, the numerical simulations of directional wave spectrum evolution were used to interpret and to compare with the aircraft data from Radar Ocean Wave Spectrometer (ROWS) and Surface Contour Radar (SCR) across the front during Frontal Air Sea Interaction Experiment (FASINEX). The wave-ice interaction was inspired by the observation of large amplitude waves hundreds of kms inside the ice pack in the Weddell Sea, resulting in breakup of the ice pack. The developed analysis of processes includes the refraction of waves at the pack edge, the effects of pack compression on wave propagation, wave train stability and buckling stability in the ice pack. Sources of pack compression and interaction between wave momentum and pack compression are investigated. Viscous camping of propagating waves in the marginal ice zone are also studied. The analysis suggests an explanation for the change in wave dispersion observed from the ship and the sequence of processes that cause ice pack breakup, pressure ridge formation and the formation of open bands of water.

  5. Interacting Boson Model and nucleons

    NASA Astrophysics Data System (ADS)

    Otsuka, Takaharu

    2012-10-01

    An overview on the recent development of the microscopic derivation of the Interacting Boson Model is presented with some remarks not found elsewhere. The OAI mapping is reviewed very briefly, including the basic correspondence from nucleon-pair to boson. The new fermionboson mapping method is introduced, where intrinsic states of nucleons and bosons for a wide variation of shapes play an important role. Nucleon intrinsic states are obtained from mean field models, which is Skyrme model in examples to be shown. This method generates IBM-2 Hamiltonian which can describe and predict various situations of quadrupole collective states, including U(5), SU(3), O(6) and E(5) limits. The method is extended so that rotational response (cranking) can be handled, which enables us to describe rotational bands of strongly deformed nuclei. Thus, we have obtained a unified framework for the microscopic derivation of the IBM covering all known situations of quadrupole collectivity at low energy.

  6. Modelling Positron Interactions with Matter

    NASA Astrophysics Data System (ADS)

    Garcia, G.; Petrovic, Z.; White, R.; Buckman, S.

    2011-05-01

    In this work we link fundamental measurements of positron interactions with biomolecules, with the development of computer codes for positron transport and track structure calculations. We model positron transport in a medium from a knowledge of the fundamental scattering cross section for the atoms and molecules comprising the medium, combined with a transport analysis based on statistical mechanics and Monte-Carlo techniques. The accurate knowledge of the scattering is most important at low energies, a few tens of electron volts or less. The ultimate goal of this work is to do this in soft condensed matter, with a view to ultimately developing a dosimetry model for Positron Emission Tomography (PET). The high-energy positrons first emitted by a radionuclide in PET may well be described by standard formulas for energy loss of charged particles in matter, but it is incorrect to extrapolate these formulas to low energies. Likewise, using electron cross-sections to model positron transport at these low energies has been shown to be in serious error due to the effects of positronium formation. Work was supported by the Australian Research Council, the Serbian Government, and the Ministerio de Ciencia e Innovación, Spain.

  7. Anselm's Discovery of the Gross-Neveu Model in 1958

    NASA Astrophysics Data System (ADS)

    Shifman, M.

    2013-06-01

    The Gross-Neveu model comprises quantum field theory of N Dirac fermions interacting via four-fermion interaction in one spatial and one time dimension. It was introduced in 1974 (shortly after quantum chromodynamics was discovered) by David Gross and André Neveu [1] as a toy model which mimics two crucial features of quantum chromodynamics: asymptotic freedom and spontaneous breaking of a chiral symmetry. The model is based on N Dirac (i.e. complex two-component) fermions, ψ1, ψ2, ..., ψN. The Lagrangian of the Gross-Neveau model is [ {L} = bar{psi}ipartial_{mu}gamma^{mu}psi + frac{g^{2}}{2}(sumlimits_{k = 1}^{N}bar{psi}_{k}psi^{k})^{2}.

  8. ISS Plasma Interaction: Measurements and Modeling

    NASA Technical Reports Server (NTRS)

    Barsamian, H.; Mikatarian, R.; Alred, J.; Minow, J.; Koontz, S.

    2004-01-01

    Ionospheric plasma interaction effects on the International Space Station are discussed in the following paper. The large structure and high voltage arrays of the ISS represent a complex system interacting with LEO plasma. Discharge current measurements made by the Plasma Contactor Units and potential measurements made by the Floating Potential Probe delineate charging and magnetic induction effects on the ISS. Based on theoretical and physical understanding of the interaction phenomena, a model of ISS plasma interaction has been developed. The model includes magnetic induction effects, interaction of the high voltage solar arrays with ionospheric plasma, and accounts for other conductive areas on the ISS. Based on these phenomena, the Plasma Interaction Model has been developed. Limited verification of the model has been performed by comparison of Floating Potential Probe measurement data to simulations. The ISS plasma interaction model will be further tested and verified as measurements from the Floating Potential Measurement Unit become available, and construction of the ISS continues.

  9. Method and apparatus for modeling interactions

    DOEpatents

    Xavier, Patrick G.

    2002-01-01

    The present invention provides a method and apparatus for modeling interactions that overcomes drawbacks. The method of the present invention comprises representing two bodies undergoing translations by two swept volume representations. Interactions such as nearest approach and collision can be modeled based on the swept body representations. The present invention is more robust and allows faster modeling than previous methods.

  10. An Interaction-Centric Learning Model.

    ERIC Educational Resources Information Center

    Ohl, Todd Michael

    2001-01-01

    Considers whether current definitions of interactivity in educational software are optimal and suggests a new model of interaction based on how learners interact mentally with new schema and on educational psychology. Discusses knowledge acquisition; production, or the creation of new knowledge; collaboration; and applying the learning interaction…

  11. Child Characteristics by Model Interactions.

    ERIC Educational Resources Information Center

    Featherstone, Helen J.

    Data from the 1969-70 and 1970-71 Head Start Planned Variation (HSPV)Study were used to examine program-child interactions. An effort was made to determine whether different preschool programs have different cognitive effects on different types of children. Seven hypotheses for the analysis of the data were generated from the results of the HSPV…

  12. The Monash University Interactive Simple Climate Model

    NASA Astrophysics Data System (ADS)

    Dommenget, D.

    2013-12-01

    The Monash university interactive simple climate model is a web-based interface that allows students and the general public to explore the physical simulation of the climate system with a real global climate model. It is based on the Globally Resolved Energy Balance (GREB) model, which is a climate model published by Dommenget and Floeter [2011] in the international peer review science journal Climate Dynamics. The model simulates most of the main physical processes in the climate system in a very simplistic way and therefore allows very fast and simple climate model simulations on a normal PC computer. Despite its simplicity the model simulates the climate response to external forcings, such as doubling of the CO2 concentrations very realistically (similar to state of the art climate models). The Monash simple climate model web-interface allows you to study the results of more than a 2000 different model experiments in an interactive way and it allows you to study a number of tutorials on the interactions of physical processes in the climate system and solve some puzzles. By switching OFF/ON physical processes you can deconstruct the climate and learn how all the different processes interact to generate the observed climate and how the processes interact to generate the IPCC predicted climate change for anthropogenic CO2 increase. The presentation will illustrate how this web-base tool works and what are the possibilities in teaching students with this tool are.

  13. The Monash University Interactive Simple Climate Model

    NASA Astrophysics Data System (ADS)

    Dommenget, Dietmar

    2013-04-01

    The Monash university interactive simple climate model is a web-based interface that allows students and the general public to explore the physical simulation of the climate system with a real global climate model. It is based on the Globally Resolved Energy Balance (GREB) model, which is a climate model published by Dommenget and Floeter [2011] in the international peer review science journal Climate Dynamics. The model simulates most of the main physical processes in the climate system in a very simplistic way and therefore allows very fast and simple climate model simulations on a normal PC computer. Despite its simplicity the model simulates the climate response to external forcings, such as doubling of the CO2 concentrations very realistically (similar to state of the art climate models). The Monash simple climate model web-interface allows you to study the results of more than a 1000 different model experiments in an interactive way and it allows you to study a number of tutorials on the interactions of physical processes in the climate system. By switching OFF/ON physical processes you can deconstruct the climate and learn how all the different processes interact to generate the observed climate and how the processes interact to generate the IPCC predicted climate change for anthropogenic CO2 increase. The presentation will illustrate how this web-base tool works and what are the possibilities in teaching students with this tool are.

  14. SABRINA - an interactive geometry modeler for MCNP

    SciTech Connect

    West, J.T.; Murphy, J. )

    1988-01-01

    One of the most difficult tasks when analyzing a complex three-dimensional system with Monte Carlo is geometry model development. SABRINA attempts to make the modeling process more user-friendly and less of an obstacle. It accepts both combinatorial solid bodies and MCNP surfaces and produces MCNP cells. The model development process in SABRINA is highly interactive and gives the user immediate feedback on errors. Users can view their geometry from arbitrary perspectives while the model is under development and interactively find and correct modeling errors. An example of a SABRINA display is shown. It represents a complex three-dimensional shape.

  15. Modeling of laser interactions with composite materials

    DOE PAGES

    Rubenchik, Alexander M.; Boley, Charles D.

    2013-05-07

    In this study, we develop models of laser interactions with composite materials consisting of fibers embedded within a matrix. A ray-trace model is shown to determine the absorptivity, absorption depth, and optical power enhancement within the material, as well as the angular distribution of the reflected light. We also develop a macroscopic model, which provides physical insight and overall results. We show that the parameters in this model can be determined from the ray trace model.

  16. Modeling interaction for image-guided procedures

    NASA Astrophysics Data System (ADS)

    Trevisan, Daniela G.; Vanderdonckt, Jean; Macq, Benoit M. M.; Raftopoulos, Christian

    2003-05-01

    Compared to conventional interfaces, image guided surgery (IGS) interfaces contain a richer variety and more complex objects and interaction types. The main interactive characteristics emering from systems like this is the interaction focus shared between physical space, where the surgeon interacts with the patient using surgical tools, and with the digital world, where the surgeon interacts with the system. This limitation results in two different interfaces likely inconsistent, thereby the interaction discontinuities do break the natuarl workflow forcing the user to switch between the operation modes. Our work addresses these features by focusing on the model, interaction and ergonomic integrity analysis considering the Augmented Reality paradigm applied to IGS procedures and more specifically applied to the Neurosurgery study case. We followed a methodology according to the model-based approach, including new extensions in order to support interaction technologies and to sensure continuity interaction according to the IGS system requirements. As a result, designers may as soon as possible discover errors in the development process and may perform an efficient interface design coherently integrating constraints favoring continuity instead of discrete interaction with possible inconsistencies.

  17. Lattice gas models with long range interactions

    NASA Astrophysics Data System (ADS)

    Aristoff, David; Zhu, Lingjiong

    2017-02-01

    We study microcanonical lattice gas models with long range interactions, including power law interactions. We rigorously obtain a variational principle for the entropy. In a one dimensional example, we find a first order phase transition by proving the entropy is non-differentiable along a certain curve.

  18. Key Results of Interaction Models with Centering

    ERIC Educational Resources Information Center

    Afshartous, David; Preston, Richard A.

    2011-01-01

    We consider the effect on estimation of simultaneous variable centering and interaction effects in linear regression. We technically define, review, and amplify many of the statistical issues for interaction models with centering in order to create a useful and compact reference for teachers, students, and applied researchers. In addition, we…

  19. Modeling Interaction Effects in Latent Growth Curve Models.

    ERIC Educational Resources Information Center

    Li, Fuzhong; Duncan, Terry E.; Acock, Alan

    2000-01-01

    Presents an extension of the method of estimating interaction effects among latent variables to latent growth curve models developed by K. Joreskog and F. Yang (1996). Illustrates the procedure and discusses results in terms of practical and statistical problems associated with interaction analyses in latent curve models and structural equation…

  20. Evaluating Interactive Instructional Technologies: A Cognitive Model.

    ERIC Educational Resources Information Center

    Tucker, Susan A.

    Strengths and weaknesses of prevailing evaluation models are analyzed, with attention to the role of feedback in each paradigm. A framework is then presented for analyzing issues faced by evaluators of interactive instructional technologies. The current practice of evaluation relies heavily on 3 models developed over 20 years ago: (1) the…

  1. Method and apparatus for modeling interactions

    DOEpatents

    Xavier, Patrick G.

    2000-08-08

    A method and apparatus for modeling interactions between bodies. The method comprises representing two bodies undergoing translations and rotations by two hierarchical swept volume representations. Interactions such as nearest approach and collision can be modeled based on the swept body representations. The present invention can serve as a practical tool in motion planning, CAD systems, simulation systems, safety analysis, and applications that require modeling time-based interactions. A body can be represented in the present invention by a union of convex polygons and convex polyhedra. As used generally herein, polyhedron includes polygon, and polyhedra includes polygons. The body undergoing translation can be represented by a swept body representation, where the swept body representation comprises a hierarchical bounding volume representation whose leaves each contain a representation of the region swept by a section of the body during the translation, and where the union of the regions is a superset of the region swept by the surface of the body during translation. Interactions between two bodies thus represented can be modeled by modeling interactions between the convex hulls of the finite sets of discrete points in the swept body representations.

  2. Interactive simulation of needle insertion models.

    PubMed

    DiMaio, Simon P; Salcudean, Septimiu E

    2005-07-01

    A novel interactive virtual needle insertion simulation is presented. The simulation models are based on measured planar tissue deformations and needle insertion forces. Since the force-displacement relationship is only of interest along the needle shaft, a condensation technique is shown to reduce the computational complexity of linear simulation models significantly. As the needle penetrates or is withdrawn from the tissue model, the boundary conditions that determine the tissue and needle motion change. Boundary condition and local material coordinate changes are facilitated by fast low-rank matrix updates. A large-strain elastic needle model is coupled to the tissue models to account for needle deflection and bending during simulated insertion. A haptic environment, based on these novel interactive simulation techniques, allows users to manipulate a three-degree-of-freedom virtual needle as it penetrates virtual tissue models, while experiencing steering torques and lateral needle forces through a planar haptic interface.

  3. Multisite Interactions in Lattice-Gas Models

    NASA Astrophysics Data System (ADS)

    Einstein, T. L.; Sathiyanarayanan, R.

    For detailed applications of lattice-gas models to surface systems, multisite interactions often play at least as significant a role as interactions between pairs of adatoms that are separated by a few lattice spacings. We recall that trio (3-adatom, non-pairwise) interactions do not inevitably create phase boundary asymmetries about half coverage. We discuss a sophisticated application to an experimental system and describe refinements in extracting lattice-gas energies from calculations of total energies of several different ordered overlayers. We describe how lateral relaxations complicate matters when there is direct interaction between the adatoms, an issue that is important when examining the angular dependence of step line tensions. We discuss the connector model as an alternative viewpoint and close with a brief account of recent work on organic molecule overlayers.

  4. An experiment with interactive planning models

    NASA Technical Reports Server (NTRS)

    Beville, J.; Wagner, J. H.; Zannetos, Z. S.

    1970-01-01

    Experiments on decision making in planning problems are described. Executives were tested in dealing with capital investments and competitive pricing decisions under conditions of uncertainty. A software package, the interactive risk analysis model system, was developed, and two controlled experiments were conducted. It is concluded that planning models can aid management, and predicted uses of the models are as a central tool, as an educational tool, to improve consistency in decision making, to improve communications, and as a tool for consensus decision making.

  5. Gauged Nambu-Jona-Lasinio model with extra dimensions: Phase structure and renormalizability

    SciTech Connect

    Gusynin, Valery P.; Hashimoto, Michio; Tanabashi, Masaharu; Yamawaki, Koichi

    2004-11-01

    We investigate phase structure of the D(>4)-dimensional gauged Nambu-Jona-Lasinio (NJL) model with {delta}(=D-4) extra dimensions compactified on TeV scale, based on the improved ladder Schwinger-Dyson (SD) equation in the bulk. We assume that the bulk (dimensionless) running gauge coupling in the SD equation for the SU(N{sub c}) gauge theory with N{sub f} massless flavors is given by the truncated Kaluza-Klein effective theory and hence has a nontrivial ultraviolet fixed point (UVFP), resulting in the walking coupling. We find the critical line in the parameter space of two couplings, the gauge coupling (value fixed at the UVFP) and the (dimensionless) four-fermion coupling, which is similar to that of the gauged NJL model with fixed (walking) gauge coupling in four dimensions. It is shown that in the presence of such walking gauge interactions the four-fermion interactions become nontrivial and renormalizable even in higher dimensions, similar to the four dimensional gauged NJL model. Such a renormalizability/nontriviality holds only in the restricted region of the critical line ('nontrivial window') with the gauge coupling larger than a nonvanishing value ('marginal triviality' point), in contrast to the four dimensional case where such a renormalizability holds for all regions of the critical line except for the pure NJL point (without gauge coupling). In the nontrivial window the renormalized effective potential yields a nontrivial interaction which is conformal invariant. The existence of the nontrivial window implies 'cutoff insensitivity' of the physics prediction in spite of the ultraviolet dominance of the dynamics. In the formal limit D{yields}4, the nontrivial window shrinks to the pure NJL point but with a nontrivial condition which coincides with the known condition of the renormalizability/nontriviality of the four dimensional gauged NJL model (9/2)(1/N{sub c})

  6. Quark interchange model of baryon interactions

    SciTech Connect

    Maslow, J.N.

    1983-01-01

    The strong interactions at low energy are traditionally described by meson field theories treating hadrons as point-like particles. Here a mesonic quark interchange model (QIM) is presented which takes into account the finite size of the baryons and the internal quark structure of hadrons. The model incorporates the basic quark-gluon coupling of quantum chromodynamics (QCD) and the MIT bag model for color confinement. Because the quark-gluon coupling constant is large and it is assumed that confinement excludes overlap of hadronic quark bags except at high momenta, a non-perturbative method of nuclear interactions is presented. The QIM allows for exchange of quark quantum numbers at the bag boundary between colliding hadrons mediated at short distances by a gluon exchange between two quarks within the hadronic interior. This generates, via a Fierz transformation, an effective space-like t channel exchange of color singlet (q anti-q) states that can be identified with the low lying meson multiplets. Thus, a one boson exchange (OBE) model is obtained that allows for comparison with traditional phenomenological models of nuclear scattering. Inclusion of strange quarks enables calculation of YN scattering. The NN and YN coupling constants and the nucleon form factors show good agreement with experimental values as do the deuteron low energy data and the NN low energy phase shifts. Thus, the QIM provides a simple model of strong interactions that is chirally invariant, includes confinement and allows for an OBE form of hadronic interaction at low energies and momentum transfers.

  7. Interactive Visual Analysis within Dynamic Ocean Models

    NASA Astrophysics Data System (ADS)

    Butkiewicz, T.

    2012-12-01

    The many observation and simulation based ocean models available today can provide crucial insights for all fields of marine research and can serve as valuable references when planning data collection missions. However, the increasing size and complexity of these models makes leveraging their contents difficult for end users. Through a combination of data visualization techniques, interactive analysis tools, and new hardware technologies, the data within these models can be made more accessible to domain scientists. We present an interactive system that supports exploratory visual analysis within large-scale ocean flow models. The currents and eddies within the models are illustrated using effective, particle-based flow visualization techniques. Stereoscopic displays and rendering methods are employed to ensure that the user can correctly perceive the complex 3D structures of depth-dependent flow patterns. Interactive analysis tools are provided which allow the user to experiment through the introduction of their customizable virtual dye particles into the models to explore regions of interest. A multi-touch interface provides natural, efficient interaction, with custom multi-touch gestures simplifying the otherwise challenging tasks of navigating and positioning tools within a 3D environment. We demonstrate the potential applications of our visual analysis environment with two examples of real-world significance: Firstly, an example of using customized particles with physics-based behaviors to simulate pollutant release scenarios, including predicting the oil plume path for the 2010 Deepwater Horizon oil spill disaster. Secondly, an interactive tool for plotting and revising proposed autonomous underwater vehicle mission pathlines with respect to the surrounding flow patterns predicted by the model; as these survey vessels have extremely limited energy budgets, designing more efficient paths allows for greater survey areas.

  8. Interaction Effects in Growth Modeling: A Full Model.

    ERIC Educational Resources Information Center

    Wen, Zhonglin; Marsh, Herbert W.; Hau, Kit-Tai

    2002-01-01

    Points out two concerns with recent research by F. Li and others (2000) and T. Duncan and others (1999) that extended the structural equation model of latent interactions developed by K. Joreskog and F. Yang (1996) to latent growth modeling. Used mathematical derivation and a comparison of alternative models fitted to simulated data to develop a…

  9. Interactive Activation Model of Speech Perception.

    DTIC Science & Technology

    1984-11-01

    contract. 0 Elar, .l... & .McC’lelland .1.1. Speech perception a, a cognitive proces,: The interactive act ia- %e., tion model of speech perception. In...attempts to provide a machine solution to the problem of speech perception. A second kind of model, growing out of Cognitive Psychology, attempts to...architectures to cognitive and perceptual problems. We also owe a debt to what we might call the computational connectionists -- those who have applied highly

  10. Statistical pairwise interaction model of stock market

    NASA Astrophysics Data System (ADS)

    Bury, Thomas

    2013-03-01

    Financial markets are a classical example of complex systems as they are compound by many interacting stocks. As such, we can obtain a surprisingly good description of their structure by making the rough simplification of binary daily returns. Spin glass models have been applied and gave some valuable results but at the price of restrictive assumptions on the market dynamics or they are agent-based models with rules designed in order to recover some empirical behaviors. Here we show that the pairwise model is actually a statistically consistent model with the observed first and second moments of the stocks orientation without making such restrictive assumptions. This is done with an approach only based on empirical data of price returns. Our data analysis of six major indices suggests that the actual interaction structure may be thought as an Ising model on a complex network with interaction strengths scaling as the inverse of the system size. This has potentially important implications since many properties of such a model are already known and some techniques of the spin glass theory can be straightforwardly applied. Typical behaviors, as multiple equilibria or metastable states, different characteristic time scales, spatial patterns, order-disorder, could find an explanation in this picture.

  11. Multi-scale modeling of chemotactic interactions

    NASA Astrophysics Data System (ADS)

    Grima, Ramon

    Biological complexity emerges from the synthesis of biochemical, chemical and physical phenomena. In recent years there has been an intense effort in modeling various cellular systems of interest to understand how the observed complexity emerges from the underlying mechanisms. Most modeling approaches are based on a population description of the cells: these methods, though usually amenable to calculation, are only valid in the limit of large numbers of interacting cells. Many systems of interest involve the interaction of a relatively small number of cells; even biological systems composed of thousands of cells have spatially extended regions over which the number density of cells is small. For the latter cases, population descriptions are not valid and individual based models become a necessity. Such models, usually cellular automaton models, have been numerically studied in recent years; however, these models are not usually amenable to analytic calculation. The work presented in this thesis seeks to fulfill a gap in modeling approaches to the understanding of biocomplexity by constructing an individual based model on which analysis is possible, through the methods of statistical physics and the theory of stochastic processes. This model will be used to study the differences between individual based and population based models and the range of applicability of the latter. For the sake of comparison of the two, new efficient computational algorithms are devised for the simulation of both types of models. We finally complete our multiscale study of modeling by investigating the robustness of individual based models; this meaning a comparison of the results of different microscopic descriptions modeling the same underlying phenomena.

  12. Algebraic Turbulence-Chemistry Interaction Model

    NASA Technical Reports Server (NTRS)

    Norris, Andrew T.

    2012-01-01

    The results of a series of Perfectly Stirred Reactor (PSR) and Partially Stirred Reactor (PaSR) simulations are compared to each other over a wide range of operating conditions. It is found that the PaSR results can be simulated by a PSR solution with just an adjusted chemical reaction rate. A simple expression has been developed that gives the required change in reaction rate for a PSR solution to simulate the PaSR results. This expression is the basis of a simple turbulence-chemistry interaction model. The interaction model that has been developed is intended for use with simple one-step global reaction mechanisms and for steady-state flow simulations. Due to the simplicity of the model there is very little additional computational cost in adding it to existing CFD codes.

  13. Peppytides: Interactive Models of Polypeptide Chains

    SciTech Connect

    Zuckermann, Ron; Chakraborty, Promita; Derisi, Joe

    2014-01-21

    Peppytides are scaled, 3D-printed models of polypeptide chains that can be folded into accurate protein structures. Designed and created by Berkeley Lab Researcher, Promita Chakraborty, and Berkeley Lab Senior Scientist, Dr. Ron Zuckermann, Peppytides are accurate physical models of polypeptide chains that anyone can interact with and fold intro various protein structures - proving to be a great educational tool, resulting in a deeper understanding of these fascinating structures and how they function. Build your own Peppytide model and learn about how nature's machines fold into their intricate architectures!

  14. Peppytides: Interactive Models of Polypeptide Chains

    ScienceCinema

    Zuckermann, Ron; Chakraborty, Promita; Derisi, Joe

    2016-07-12

    Peppytides are scaled, 3D-printed models of polypeptide chains that can be folded into accurate protein structures. Designed and created by Berkeley Lab Researcher, Promita Chakraborty, and Berkeley Lab Senior Scientist, Dr. Ron Zuckermann, Peppytides are accurate physical models of polypeptide chains that anyone can interact with and fold intro various protein structures - proving to be a great educational tool, resulting in a deeper understanding of these fascinating structures and how they function. Build your own Peppytide model and learn about how nature's machines fold into their intricate architectures!

  15. Interactive mapping on 3-D terrain models

    NASA Astrophysics Data System (ADS)

    Bernardin, T.; Cowgill, E.; Gold, R.; Hamann, B.; Kreylos, O.; Schmitt, A.

    2006-10-01

    We present an interactive, real-time mapping system for use with digital elevation models and remotely sensed multispectral imagery that aids geoscientists in the creation and interpretation of geologic/neotectonic maps at length scales of 10 m to 1000 km. Our system provides a terrain visualization of the surface of the Earth or other terrestrial planets by displaying a virtual terrain model generated from a digital elevation model overlain by a color texture generated from orthophotos or satellite imagery. We use a quadtree-based, multiresolution display method to render in real time high-resolution virtual terrain models that span large spatial regions. The system allows users to measure the orientations of geologic surfaces and record their observations by drawing lines directly on the virtual terrain model. In addition, interpretive surfaces can be generated from these drawings and displayed to facilitate understanding of the three-dimensional geometry of geologic surfaces. The main strength of our system is the combination of real-time rendering and interactive mapping performed directly on the virtual terrain model with the ability to navigate the scene while changing viewpoints arbitrarily during mapping. User studies and comparisons with commercially available mapping software show that our system improves mapping accuracy and efficiency and also yields observations that cannot be made with existing systems.

  16. Characterizing nanoparticle interactions: Linking models to experiments

    SciTech Connect

    Ramakrishnan, S.; Zukoski, C. F.

    2000-07-15

    Self-assembly of nanoparticles involves manipulating particle interactions such that attractions are on the order of the average thermal energy in the system. If the self-assembly is to result in an ordered packing, an understanding of their phase behavior is necessary. Here we test the ability of simple pair potentials to characterize the interactions and phase behavior of silico tungstic acid (STA), a 1.2 nm particle. The strength of interaction is controlled by dispersing STA in different background salt concentrations. The experimental variables used in characterizing the interactions are the osmotic compressibility (d{pi}/d{rho}), the second virial coefficient (B{sub 2}), relative solution viscosity ({eta}/{eta}{sub c}), and the solubility ({rho}{sigma}{sup 3}){sub sat}. Various techniques are then developed to extract the parameters of square well, the adhesive hard sphere (AHS), and the Yukawa pair potentials that best describe the experimental data. The AHS model describes the solution thermodynamic behavior only where the system is weakly attractive but, as would be expected, fails when long range repulsions or nonmonotonic pair potentials become important. Model free representations are presented which offer the opportunity to extract pair potential parameters. (c) 2000 American Institute of Physics.

  17. Interacting Dark Energy Models and Observations

    NASA Astrophysics Data System (ADS)

    Shojaei, Hamed; Urioste, Jazmin

    2017-01-01

    Dark energy is one of the mysteries of the twenty first century. Although there are candidates resembling some features of dark energy, there is no single model describing all the properties of dark energy. Dark energy is believed to be the most dominant component of the cosmic inventory, but a lot of models do not consider any interaction between dark energy and other constituents of the cosmic inventory. Introducing an interaction will change the equation governing the behavior of dark energy and matter and creates new ways to explain cosmic coincidence problem. In this work we studied how the Hubble parameter and density parameters evolve with time in the presence of certain types of interaction. The interaction serves as a way to convert dark energy into matter to avoid a dark energy-dominated universe by creating new equilibrium points for the differential equations. Then we will use numerical analysis to predict the values of distance moduli at different redshifts and compare them to the values for the distance moduli obtained by WMAP (Wilkinson Microwave Anisotropy Probe). Undergraduate Student

  18. PRIMO: An Interactive Homology Modeling Pipeline

    PubMed Central

    Glenister, Michael

    2016-01-01

    The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These servers make calculations simpler, but largely exclude users from the process. In this study, we present the PRotein Interactive MOdeling (PRIMO) pipeline for homology modeling of protein monomers. The pipeline eases the multi-step modeling process, and reduces the workload required by the user, while still allowing engagement from the user during every step. Default parameters are given for each step, which can either be modified or supplemented with additional external input. PRIMO has been designed for users of varying levels of experience with homology modeling. The pipeline incorporates a user-friendly interface that makes it easy to alter parameters used during modeling. During each stage of the modeling process, the site provides suggestions for novice users to improve the quality of their models. PRIMO provides functionality that allows users to also model ligands and ions in complex with their protein targets. Herein, we assess the accuracy of the fully automated capabilities of the server, including a comparative analysis of the available alignment programs, as well as of the refinement levels used during modeling. The tests presented here demonstrate the reliability of the PRIMO server when producing a large number of protein models. While PRIMO does focus on user involvement in the homology modeling process, the results indicate that in the presence of suitable templates, good quality models can be produced even without user intervention. This gives an idea of the base level accuracy of PRIMO, which users can improve upon by adjusting parameters in their modeling runs. The accuracy of PRIMO’s automated scripts is being continuously evaluated by the CAMEO (Continuous Automated Model EvaluatiOn) project. The PRIMO site is free for non-commercial use and can be accessed at https://primo.rubi.ru.ac.za/. PMID:27855192

  19. Method of and apparatus for modeling interactions

    DOEpatents

    Budge, Kent G.

    2004-01-13

    A method and apparatus for modeling interactions can accurately model tribological and other properties and accommodate topological disruptions. Two portions of a problem space are represented, a first with a Lagrangian mesh and a second with an ALE mesh. The ALE and Lagrangian meshes are constructed so that each node on the surface of the Lagrangian mesh is in a known correspondence with adjacent nodes in the ALE mesh. The interaction can be predicted for a time interval. Material flow within the ALE mesh can accurately model complex interactions such as bifurcation. After prediction, nodes in the ALE mesh in correspondence with nodes on the surface of the Lagrangian mesh can be mapped so that they are once again adjacent to their corresponding Lagrangian mesh nodes. The ALE mesh can then be smoothed to reduce mesh distortion that might reduce the accuracy or efficiency of subsequent prediction steps. The process, from prediction through mapping and smoothing, can be repeated until a terminal condition is reached.

  20. Nagaoka's atomic model and hyperfine interactions.

    PubMed

    Inamura, Takashi T

    2016-01-01

    The prevailing view of Nagaoka's "Saturnian" atom is so misleading that today many people have an erroneous picture of Nagaoka's vision. They believe it to be a system involving a 'giant core' with electrons circulating just outside. Actually, though, in view of the Coulomb potential related to the atomic nucleus, Nagaoka's model is exactly the same as Rutherford's. This is true of the Bohr atom, too. To give proper credit, Nagaoka should be remembered together with Rutherford and Bohr in the history of the atomic model. It is also pointed out that Nagaoka was a pioneer of understanding hyperfine interactions in order to study nuclear structure.

  1. Comments on interactions in the SUSY models

    NASA Astrophysics Data System (ADS)

    Upadhyay, Sudhaker; Reshetnyak, Alexander; Mandal, Bhabani Prasad

    2016-07-01

    We consider special supersymmetry (SUSY) transformations with m generators overleftarrow{s}_α , for some class of models and study the physical consequences when making the Grassmann-odd transformations to form an Abelian supergroup with finite parameters and a set of group-like elements with finite parameters being functionals of the field variables. The SUSY-invariant path integral measure within conventional quantization scheme leads to the appearance of the Jacobian under a change of variables generated by such SUSY transformations, which is explicitly calculated. The Jacobian implies, first of all, the appearance of trivial interactions in the transformed action, and, second, the presence of a modified Ward identity which reduces to the standard Ward identities in the case of constant parameters. We examine the case of the {N}=1 and N=2 supersymmetric harmonic oscillators to illustrate the general concept by a simple free model with (1, 1) physical degrees of freedom. It is shown that the interaction terms U_{tr} have a corresponding SUSY-exact form: U_{tr}= big (V_{(1)}overleftarrow{s}; V_{(2)}overleftarrow{bar{s}} overleftarrow{s}big ) generated naturally under such generalized formulation. We argue that the case of a non-trivial interaction cannot be obtained in such a way.

  2. Interacting damage models mapped onto ising and percolation models

    SciTech Connect

    Toussaint, Renaud; Pride, Steven R.

    2004-03-23

    The authors introduce a class of damage models on regular lattices with isotropic interactions between the broken cells of the lattice. Quasistatic fiber bundles are an example. The interactions are assumed to be weak, in the sense that the stress perturbation from a broken cell is much smaller than the mean stress in the system. The system starts intact with a surface-energy threshold required to break any cell sampled from an uncorrelated quenched-disorder distribution. The evolution of this heterogeneous system is ruled by Griffith's principle which states that a cell breaks when the release in potential (elastic) energy in the system exceeds the surface-energy barrier necessary to break the cell. By direct integration over all possible realizations of the quenched disorder, they obtain the probability distribution of each damage configuration at any level of the imposed external deformation. They demonstrate an isomorphism between the distributions so obtained and standard generalized Ising models, in which the coupling constants and effective temperature in the Ising model are functions of the nature of the quenched-disorder distribution and the extent of accumulated damage. In particular, they show that damage models with global load sharing are isomorphic to standard percolation theory, that damage models with local load sharing rule are isomorphic to the standard ising model, and draw consequences thereof for the universality class and behavior of the autocorrelation length of the breakdown transitions corresponding to these models. they also treat damage models having more general power-law interactions, and classify the breakdown process as a function of the power-law interaction exponent. Last, they also show that the probability distribution over configurations is a maximum of Shannon's entropy under some specific constraints related to the energetic balance of the fracture process, which firmly relates this type of quenched-disorder based damage model

  3. PDF modeling of turbulence-radiation interactions

    SciTech Connect

    Mazumder, S.; Modest, M.F.

    1997-07-01

    The interactions between turbulence and radiation, although acknowledged and qualitatively understood over the last several decades, are extremely difficult to model. Traditional Eulerian turbulence models are incapable of addressing the closure problem for any realistic reactive flow situation, because of the large number of unknown turbulent moments that need to be modeled. A novel approach, based on the velocity-composition joint probability density function (PDF) method, is presented. This approach is Lagrangian in nature and provides an elegant and feasible alternative to turbulence closure. A mixed Monte Carlo/finite-volume technique is used to simulate a bluff-body-stabilized methane-air diffusion flame in a two-dimensional planar recirculating combustor, and enables treatment of turbulence in recirculating flows, finite-rate chemistry, and multiple-band radiation calculations within the CPU limitations of a standard single-processor workstation. Results demonstrate the role of radiation and turbulence-radiation interactions in altering the overall flame structure, the wall heat loads, and the overall heat emission by the flame at various Reynolds numbers and equivalence ratios.

  4. Optimal Scaling of Interaction Effects in Generalized Linear Models

    ERIC Educational Resources Information Center

    van Rosmalen, Joost; Koning, Alex J.; Groenen, Patrick J. F.

    2009-01-01

    Multiplicative interaction models, such as Goodman's (1981) RC(M) association models, can be a useful tool for analyzing the content of interaction effects. However, most models for interaction effects are suitable only for data sets with two or three predictor variables. Here, we discuss an optimal scaling model for analyzing the content of…

  5. Interaction of Mastoparan with Model Membranes

    NASA Astrophysics Data System (ADS)

    Haloot, Justin

    2010-10-01

    The use of antimicrobial agents began during the 20th century to reduce the effects of infectious diseases. Since the 1990s, antimicrobial resistance has become an ever-increasing global problem. Our laboratory recently found that small antimicrobial peptides (AMPs) have potent antimicrobial activity against a wide range of Gram-negative and Gram-positive organisms including antibiotic resistant organisms. These AMPs are potential therapeutic agents against the growing problem of antimicrobial resistance. AMPs are small peptides produced by plants, insects and animals. Several hypotheses concede that these peptides cause some type of structural perturbations and increased membrane permeability in bacteria however, how AMPs kill bacteria remains unclear. The goal of this study was to design an assay that would allow us to evaluate and monitor the pore forming ability of an AMP, Mastoparan, on model membrane structures called liposomes. Development of this model will facilitate the study of how mastoparan and related AMPs interact with the bacterial membrane.

  6. Convex Modeling of Interactions with Strong Heredity

    PubMed Central

    Haris, Asad; Witten, Daniela; Simon, Noah

    2015-01-01

    We consider the task of fitting a regression model involving interactions among a potentially large set of covariates, in which we wish to enforce strong heredity. We propose FAMILY, a very general framework for this task. Our proposal is a generalization of several existing methods, such as VANISH [Radchenko and James, 2010], hierNet [Bien et al., 2013], the all-pairs lasso, and the lasso using only main effects. It can be formulated as the solution to a convex optimization problem, which we solve using an efficient alternating directions method of multipliers (ADMM) algorithm. This algorithm has guaranteed convergence to the global optimum, can be easily specialized to any convex penalty function of interest, and allows for a straightforward extension to the setting of generalized linear models. We derive an unbiased estimator of the degrees of freedom of FAMILY, and explore its performance in a simulation study and on an HIV sequence data set.

  7. A simple model for studying interacting networks

    NASA Astrophysics Data System (ADS)

    Liu, Wenjia; Jolad, Shivakumar; Schmittmann, Beate; Zia, R. K. P.

    2011-03-01

    Many specific physical networks (e.g., internet, power grid, interstates), have been characterized in considerable detail, but in isolation from each other. Yet, each of these networks supports the functions of the others, and so far, little is known about how their interactions affect their structure and functionality. To address this issue, we consider two coupled model networks. Each network is relatively simple, with a fixed set of nodes, but dynamically generated set of links which has a preferred degree, κ . In the stationary state, the degree distribution has exponential tails (far from κ), an attribute which we can explain. Next, we consider two such networks with different κ 's, reminiscent of two social groups, e.g., extroverts and introverts. Finally, we let these networks interact by establishing a controllable fraction of cross links. The resulting distribution of links, both within and across the two model networks, is investigated and discussed, along with some potential consequences for real networks. Supported in part by NSF-DMR-0705152 and 1005417.

  8. Search for single top quark production via contact interactions at LEP2

    NASA Astrophysics Data System (ADS)

    Abdallah, J.; Abreu, P.; Adam, W.; Adzic, P.; Albrecht, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P. P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.-D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J. E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G. J.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.-H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P. S. L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T. J. V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J. M.; Buschbeck, B.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, N.; Cavallo, F.; Chapkin, M.; Charpentier, Ph.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S. U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M. J.; Crennell, D.; Cuevas, J.; D'Hondt, J.; da Silva, T.; da Silva, W.; Della Ricca, G.; de Angelis, A.; de Boer, W.; de Clercq, C.; de Lotto, B.; de Maria, N.; de Min, A.; de Paula, L.; di Ciaccio, L.; di Simone, A.; Doroba, K.; Drees, J.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Espirito Santo, M. C.; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, Ph.; Gazis, E.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Hoffman, J.; Holmgren, S.-O.; Holt, P. J.; Houlden, M. A.; Jackson, J. N.; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, E. K.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, F.; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B. P.; Kerzel, U.; King, B. T.; Kjaer, N. J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, F.; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J. H.; Lopez, J. M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.-C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; Mc Nulty, R.; Meroni, C.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Moenig, K.; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nemecek, S.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Oliveira, O.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J. P.; Palka, H.; Papadopoulou, Th. D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M. E.; Polok, G.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Radojicic, D.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Sander, C.; Savoy-Navarro, A.; Schwickerath, U.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Tegenfeldt, F.; Timmermans, J.; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.-L.; Tyapkin, I. A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; van Dam, P.; van Eldik, J.; van Remortel, N.; van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A. J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimin, N. I.; Zintchenko, A.; Zupan, M.

    2011-02-01

    Single top quark production via four-fermion contact interactions associated to flavour-changing neutral currents was searched for in data taken by the DELPHI detector at LEP2. The data were accumulated at centre-of-mass energies ranging from 189 to 209 GeV, with an integrated luminosity of 598.1 pb-1. No evidence for a signal was found. Limits on the energy scale Λ, were set for scalar-, vector- and tensor-like coupling scenarios.

  9. Retention modelling in hydrophilic interaction chromatography.

    PubMed

    Euerby, Melvin R; Hulse, Jennifer; Petersson, Patrik; Vazhentsev, Andrey; Kassam, Karim

    2015-12-01

    The retention behaviour of acidic, basic and quaternary ammonium salts and polar neutral analytes has been evaluated on acidic, basic and neutral hydrophilic interaction chromatography (HILIC) stationary phases as a function of HILIC operating parameters such as MeCN content, buffer concentration, pH and temperature. Numerous empirical HILIC retention models (existing and newly developed ones) have been assessed for their ability to describe retention as a function of the HILIC operating parameters investigated. Retention models have been incorporated into a commercially available retention modelling programme (i.e. ACD/LC simulator) and their accuracy of retention prediction assessed. The applicability of HILIC modelling using these equations has been demonstrated in the two-dimensional isocratic (i.e. buffer concentration versus MeCN content modelling) and one-dimensional gradient separations for a range of analytes of differing physico-chemical properties on the three stationary phases. The accuracy of retention and peak width prediction was observed to be comparable to that reported in reversed-phase chromatography (RPC) retention modelling. Intriguingly, our results have confirmed that the use of gradient modelling to predict HILIC isocratic conditions and vice versa is not reliable. A relative ranking of the importance of the retention and selectivity of HILIC operating parameters has been determined using statistical approaches. For retention, the order of importance was observed to be organic content > stationary phase > temperature ≈ mobile phase pH (i.e. pH 3-6 which mainly effects the ionization of the analyte) ≈ buffer concentration. For selectivity, the nature of the stationary phase > mobile phase pH > buffer concentration > temperature > organic content.

  10. Calculating the Annihilation Rate of Weakly Interacting Massive Particles

    NASA Astrophysics Data System (ADS)

    Baumgart, Matthew; Rothstein, Ira Z.; Vaidya, Varun

    2015-05-01

    We develop a formalism that allows one to systematically calculate the weakly interacting massive particle (WIMP) annihilation rate into gamma rays whose energy far exceeds the weak scale. A factorization theorem is presented which separates the radiative corrections stemming from initial-state potential interactions from loops involving the final state. This separation allows us to go beyond the fixed order calculation, which is polluted by large infrared logarithms. For the case of Majorana WIMPs transforming in the adjoint representation of SU(2), we present the result for the resummed rate at leading double-log accuracy in terms of two initial-state partial-wave matrix elements and one hard matching coefficient. For a given model, one may calculate the cross section by finding the tree level matching coefficient and determining the value of a local four-fermion operator. The effects of resummation can be as large as 100% for a 20 TeV WIMP. However, for lighter WIMP masses relevant for the thermal relic scenario, leading-log resummation modifies the Sudakov factors only at the 10% level. Furthermore, given comparably sized Sommerfeld factors, the total effect of radiative corrections on the semi-inclusive photon annihilation rate is found to be percent level. The generalization of the formalism to other types of WIMPs is discussed.

  11. Classical interaction model for the water molecule.

    PubMed

    Baranyai, András; Bartók, Albert

    2007-05-14

    The authors propose a new classical model for the water molecule. The geometry of the molecule is built on the rigid TIP5P model and has the experimental gas phase dipole moment of water created by four equal point charges. The model preserves its rigidity but the size of the charges increases or decreases following the electric field created by the rest of the molecules. The polarization is expressed by an electric field dependent nonlinear polarization function. The increasing dipole of the molecule slightly increases the size of the water molecule expressed by the oxygen-centered sigma parameter of the Lennard-Jones interaction. After refining the adjustable parameters, the authors performed Monte Carlo simulations to check the ability of the new model in the ice, liquid, and gas phases. They determined the density and internal energy of several ice polymorphs, liquid water, and gaseous water and calculated the heat capacity, the isothermal compressibility, the isobar heat expansion coefficients, and the dielectric constant of ambient water. They also determined the pair-correlation functions of ambient water and calculated the energy of the water dimer. The accuracy of theirs results was satisfactory.

  12. Modeling mechanical interactions between cancerous mammary acini

    NASA Astrophysics Data System (ADS)

    Wang, Jeffrey; Liphardt, Jan; Rycroft, Chris

    2015-03-01

    The rules and mechanical forces governing cell motility and interactions with the extracellular matrix of a tissue are often critical for understanding the mechanisms by which breast cancer is able to spread through the breast tissue and eventually metastasize. Ex vivo experimentation has demonstrated the the formation of long collagen fibers through collagen gels between the cancerous mammary acini responsible for milk production, providing a fiber scaffolding along which cancer cells can disorganize. We present a minimal mechanical model that serves as a potential explanation for the formation of these collagen fibers and the resultant motion. Our working hypothesis is that cancerous cells induce this fiber formation by pulling on the gel and taking advantage of the specific mechanical properties of collagen. To model this system, we employ a new Eulerian, fixed grid simulation method to model the collagen as a nonlinear viscoelastic material subject to various forces coupled with a multi-agent model to describe individual cancer cells. We find that these phenomena can be explained two simple ideas: cells pull collagen radially inwards and move towards the tension gradient of the collagen gel, while being exposed to standard adhesive and collision forces.

  13. Integrating interactive computational modeling in biology curricula.

    PubMed

    Helikar, Tomáš; Cutucache, Christine E; Dahlquist, Lauren M; Herek, Tyler A; Larson, Joshua J; Rogers, Jim A

    2015-03-01

    While the use of computer tools to simulate complex processes such as computer circuits is normal practice in fields like engineering, the majority of life sciences/biological sciences courses continue to rely on the traditional textbook and memorization approach. To address this issue, we explored the use of the Cell Collective platform as a novel, interactive, and evolving pedagogical tool to foster student engagement, creativity, and higher-level thinking. Cell Collective is a Web-based platform used to create and simulate dynamical models of various biological processes. Students can create models of cells, diseases, or pathways themselves or explore existing models. This technology was implemented in both undergraduate and graduate courses as a pilot study to determine the feasibility of such software at the university level. First, a new (In Silico Biology) class was developed to enable students to learn biology by "building and breaking it" via computer models and their simulations. This class and technology also provide a non-intimidating way to incorporate mathematical and computational concepts into a class with students who have a limited mathematical background. Second, we used the technology to mediate the use of simulations and modeling modules as a learning tool for traditional biological concepts, such as T cell differentiation or cell cycle regulation, in existing biology courses. Results of this pilot application suggest that there is promise in the use of computational modeling and software tools such as Cell Collective to provide new teaching methods in biology and contribute to the implementation of the "Vision and Change" call to action in undergraduate biology education by providing a hands-on approach to biology.

  14. SABRINA: an interactive solid geometry modeling program for Monte Carlo

    SciTech Connect

    West, J.T.

    1985-01-01

    SABRINA is a fully interactive three-dimensional geometry modeling program for MCNP. In SABRINA, a user interactively constructs either body geometry, or surface geometry models, and interactively debugs spatial descriptions for the resulting objects. This enhanced capability significantly reduces the effort in constructing and debugging complicated three-dimensional geometry models for Monte Carlo Analysis.

  15. Geodynamo Modeling of Core-Mantle Interactions

    NASA Technical Reports Server (NTRS)

    Kuang, Wei-Jia; Chao, Benjamin F.; Smith, David E. (Technical Monitor)

    2001-01-01

    Angular momentum exchange between the Earth's mantle and core influences the Earth's rotation on time scales of decades and longer, in particular in the length of day (LOD) which have been measured with progressively increasing accuracy for the last two centuries. There are four possible coupling mechanisms for transferring the axial angular momentum across the core-mantle boundary (CMB): viscous, magnetic, topography, and gravitational torques. Here we use our scalable, modularized, fully dynamic geodynamo model for the core to assess the importance of these torques. This numerical model, as an extension of the Kuang-Bloxham model that has successfully simulated the generation of the Earth's magnetic field, is used to obtain numerical results in various physical conditions in terms of specific parameterization consistent with the dynamical processes in the fluid outer core. The results show that depending on the electrical conductivity of the lower mantle and the amplitude of the boundary topography at CMB, both magnetic and topographic couplings can contribute significantly to the angular momentum exchange. This implies that the core-mantle interactions are far more complex than has been assumed and that there is unlikely a single dominant coupling mechanism for the observed decadal LOD variation.

  16. Detecting abandoned objects using interacting multiple models

    NASA Astrophysics Data System (ADS)

    Becker, Stefan; Münch, David; Kieritz, Hilke; Hübner, Wolfgang; Arens, Michael

    2015-10-01

    In recent years, the wide use of video surveillance systems has caused an enormous increase in the amount of data that has to be stored, monitored, and processed. As a consequence, it is crucial to support human operators with automated surveillance applications. Towards this end an intelligent video analysis module for real-time alerting in case of abandoned objects in public spaces is proposed. The overall processing pipeline consists of two major parts. First, person motion is modeled using an Interacting Multiple Model (IMM) filter. The IMM filter estimates the state of a person according to a finite-state, discrete-time Markov chain. Second, the location of persons that stay at a fixed position defines a region of interest, in which a nonparametric background model with dynamic per-pixel state variables identifies abandoned objects. In case of a detected abandoned object, an alarm event is triggered. The effectiveness of the proposed system is evaluated on the PETS 2006 dataset and the i-Lids dataset, both reflecting prototypical surveillance scenarios.

  17. Interaction of elaiophylin with model bilayer membrane

    NASA Astrophysics Data System (ADS)

    Genova, J.; Dencheva-Zarkova, M.

    2017-01-01

    Elaiophylin is a new macrodiolide antibiotic, which is produced by the Streptomyces strains [1]. It displays biological activities against Gram-positive bacteria and fungi. The mode of action of this antibiotic has been attributed to an alteration of the membrane permeability. When this antibiotic is inserted into the bilayer membranes destabilization of the membrane and formation of ion-penetrable channels is observed. The macrodiolide antibiotic forms stable cation selective ion channels in synthetic lipid bilayer membranes. The aim of this work was to study the interactions of Elaiophylin with model bilayer membranes and to get information on the mechanical properties of lipid bilayers in presence of this antibiotic. Patch-clamp technique [2] were used in the study

  18. Interaction of arginine oligomer with model membrane

    SciTech Connect

    Yi, Dandan . E-mail: yi_dandan@yahoo.com.cn; Guoming, Li; Gao, Li; Wei, Liang

    2007-08-10

    Short oligomers of arginine (R8) have been shown to cross readily a variety of biological barriers. A hypothesis was put forward that inverted micelles form in biological membranes in the presence of arginine oligomer peptides, facilitating their transfer through the membranes. In order to define the role of peptide-lipid interaction in this mechanism, we prepared liposomes as the model membrane to study the ability of R8 inducing calcein release from liposomes, the fusion of liposomes, R8 binding to liposomes and membrane disturbing activity of the bound R8. The results show that R8 binding to liposome membrane depends on lipid compositions, negative surface charge density and interior water phase pH values of liposomes. R8 has no activity to induce the leakage of calcein from liposomes or improve liposome fusion. R8 does not permeabilize through the membrane spontaneously. These peptides delivering drugs through membranes may depend on receptors and energy.

  19. Magnetic Clouds Modeled As Interacting Toroidal Configurations

    NASA Astrophysics Data System (ADS)

    Fainberg, J.; Osherovich, V. A.

    Multiple loops can be seen in the solar corona before the onset of a coronal mass ejection (CME), during the event and after the CME. We apply multi-toroidal con- figurations to model CMEs and their interplanetary counterparts U magnetic clouds. Such solutions found as MHD bounded states describe a single toroid (ground state) and multiple toroids (excited states), (Osherovich 1975; Osherovich and Lawrence 1982). We analyze noncircular cross section of such toroids and compare the compo- nents of the magnetic field vector with in situ observations in interplanetary magnetic clouds. The interaction of CMEs with the global coronal field will also be discussed. References Osherovich, V.A., Sooln Dann No 8, 1975. Osherovich, V.A. and J.K. Lawrence, Sol. Phys. 88, 117, 1983.

  20. Institute for Multiscale Modeling of Biological Interactions

    SciTech Connect

    Paulaitis, Michael E; Garcia-Moreno, Bertrand; Lenhoff, Abraham

    2009-12-26

    The Institute for Multiscale Modeling of Biological Interactions (IMMBI) has two primary goals: Foster interdisciplinary collaborations among faculty and their research laboratories that will lead to novel applications of multiscale simulation and modeling methods in the biological sciences and engineering; and Building on the unique biophysical/biology-based engineering foundations of the participating faculty, train scientists and engineers to apply computational methods that collectively span multiple time and length scales of biological organization. The success of IMMBI will be defined by the following: Size and quality of the applicant pool for pre-doctoral and post-doctoral fellows; Academic performance; Quality of the pre-doctoral and post-doctoral research; Impact of the research broadly and to the DOE (ASCR program) mission; Distinction of the next career step for pre-doctoral and post-doctoral fellows; and Faculty collaborations that result from IMMBI activities. Specific details about accomplishments during the three years of DOE support for IMMBI have been documented in Annual Progress Reports (April 2005, June 2006, and March 2007) and a Report for a National Academy of Sciences Review (October 2005) that were submitted to DOE on the dates indicated. An overview of these accomplishments is provided.

  1. Interactive Model Visualization for NET-VISA

    NASA Astrophysics Data System (ADS)

    Kuzma, H. A.; Arora, N. S.

    2013-12-01

    NET-VISA is a probabilistic system developed for seismic network processing of data measured on the International Monitoring System (IMS) of the Comprehensive nuclear Test Ban Treaty Organization (CTBTO). NET-VISA is composed of a Generative Model (GM) and an Inference Algorithm (IA). The GM is an explicit mathematical description of the relationships between various factors in seismic network analysis. Some of the relationships inside the GM are deterministic and some are statistical. Statistical relationships are described by probability distributions, the exact parameters of which (such as mean and standard deviation) are found by training NET-VISA using recent data. The IA uses the GM to evaluate the probability of various events and associations, searching for the seismic bulletin which has the highest overall probability and is consistent with a given set of measured arrivals. An Interactive Model Visualization tool (IMV) has been developed which makes 'peeking into' the GM simple and intuitive through a web-based interfaced. For example, it is now possible to access the probability distributions for attributes of events and arrivals such as the detection rate for each station for each of 14 phases. It also clarifies the assumptions and prior knowledge that are incorporated into NET-VISA's event determination. When NET-VISA is retrained, the IMV will be a visual tool for quality control both as a means of testing that the training has been accomplished correctly and that the IMS network has not changed unexpectedly. A preview of the IMV will be shown at this poster presentation. Homepage for the IMV IMV shows current model file and reference image.

  2. Supervisor's Interactive Model of Organizational Relationships

    ERIC Educational Resources Information Center

    O'Reilly, Frances L.; Matt, John; McCaw, William P.

    2014-01-01

    The Supervisor's Interactive Model of Organizational Relationships (SIMOR) integrates two models addressed in the leadership literature and then highlights the importance of relationships. The Supervisor's Interactive Model of Organizational Relationships combines the modified Hersey and Blanchard model of situational leadership, the…

  3. Approaches to Testing Interaction Effects Using Structural Equation Modeling Methodology.

    ERIC Educational Resources Information Center

    Li, Fuzhong; Harmer, Peter; Duncan, Terry E.; Duncan, Susan C.; Acock, Alan; Boles, Shawn

    1998-01-01

    Reviews a single indicator approach and multiple indicator approaches that simplify testing interaction effects using structural equation modeling. An illustrative application examines the interactive effect of perceptions of competence and perceptions of autonomy on exercise-intrinsic motivation. (SLD)

  4. Model ecosystems with random nonlinear interspecies interactions

    NASA Astrophysics Data System (ADS)

    Santos, Danielle O. C.; Fontanari, José F.

    2004-12-01

    The principle of competitive exclusion in ecology establishes that two species living together cannot occupy the same ecological niche. Here we present a model ecosystem in which the species are described by a series of phenotypic characters and the strength of the competition between two species is given by a nondecreasing (modulating) function of the number of common characters. Using analytical tools of statistical mechanics we find that the ecosystem diversity, defined as the fraction of species that coexist at equilibrium, decreases as the complexity (i.e., number of characters) of the species increases, regardless of the modulating function. By considering both selective and random elimination of the links in the community web, we show that ecosystems composed of simple species are more robust than those composed of complex species. In addition, we show that the puzzling result that there exists either rich or poor ecosystems for a linear modulating function is not typical of communities in which the interspecies interactions are determined by a complementarity rule.

  5. Nanoparticle interaction with model lung surfactant monolayers

    PubMed Central

    Harishchandra, Rakesh Kumar; Saleem, Mohammed; Galla, Hans-Joachim

    2010-01-01

    One of the most important functions of the lung surfactant monolayer is to form the first line of defence against inhaled aerosols such as nanoparticles (NPs), which remains largely unexplored. We report here, for the first time, the interaction of polyorganosiloxane NPs (AmorSil20: 22 nm in diameter) with lipid monolayers characteristic of alveolar surfactant. To enable a better understanding, the current knowledge about an established model surface film that mimics the surface properties of the lung is reviewed and major results originating from our group are summarized. The pure lipid components dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol have been used to study the biophysical behaviour of their monolayer films spread at the air–water interface in the presence of NPs. Film balance measurements combined with video-enhanced fluorescence microscopy have been used to investigate the formation of domain structures and the changes in the surface pattern induced by NPs. We are able to show that NPs are incorporated into lipid monolayers with a clear preference for defect structures at the fluid–crystalline interface leading to a considerable monolayer expansion and fluidization. NPs remain at the air–water interface probably by coating themselves with lipids in a self-assembly process, thereby exhibiting hydrophobic surface properties. We also show that the domain structure in lipid layers containing surfactant protein C, which is potentially responsible for the proper functioning of surfactant material, is considerably affected by NPs. PMID:19846443

  6. Functionalized Anatomical Models for EM-Neuron Interaction Modeling

    PubMed Central

    Neufeld, Esra; Cassará, Antonino Mario; Montanaro, Hazael; Kuster, Niels; Kainz, Wolfgang

    2017-01-01

    The understanding of interactions between electromagnetic (EM) fields and nerves are crucial in contexts ranging from therapeutic neurostimulation to low frequency EM exposure safety. To properly consider the impact of in-vivo induced field inhomogeneity on non-linear neuronal dynamics, coupled EM-neuronal dynamics modeling is required. For that purpose, novel functionalized computable human phantoms have been developed. Their implementation and the systematic verification of the integrated anisotropic quasi-static EM solver and neuronal dynamics modeling functionality, based on the method of manufactured solutions and numerical reference data, is described. Electric and magnetic stimulation of the ulnar and sciatic nerve were modeled to help understanding a range of controversial issues related to the magnitude and optimal determination of strength-duration (SD) time constants. The results indicate the importance of considering the stimulation-specific inhomogeneous field distributions (especially at tissue interfaces), realistic models of non-linear neuronal dynamics, very short pulses, and suitable SD extrapolation models. These results and the functionalized computable phantom will influence and support the development of safe and effective neuroprosthetic devices and novel electroceuticals. Furthermore they will assist the evaluation of existing low frequency exposure standards for the entire population under all exposure conditions. PMID:27224508

  7. Functionalized anatomical models for EM-neuron Interaction modeling

    NASA Astrophysics Data System (ADS)

    Neufeld, Esra; Cassará, Antonino Mario; Montanaro, Hazael; Kuster, Niels; Kainz, Wolfgang

    2016-06-01

    The understanding of interactions between electromagnetic (EM) fields and nerves are crucial in contexts ranging from therapeutic neurostimulation to low frequency EM exposure safety. To properly consider the impact of in vivo induced field inhomogeneity on non-linear neuronal dynamics, coupled EM-neuronal dynamics modeling is required. For that purpose, novel functionalized computable human phantoms have been developed. Their implementation and the systematic verification of the integrated anisotropic quasi-static EM solver and neuronal dynamics modeling functionality, based on the method of manufactured solutions and numerical reference data, is described. Electric and magnetic stimulation of the ulnar and sciatic nerve were modeled to help understanding a range of controversial issues related to the magnitude and optimal determination of strength-duration (SD) time constants. The results indicate the importance of considering the stimulation-specific inhomogeneous field distributions (especially at tissue interfaces), realistic models of non-linear neuronal dynamics, very short pulses, and suitable SD extrapolation models. These results and the functionalized computable phantom will influence and support the development of safe and effective neuroprosthetic devices and novel electroceuticals. Furthermore they will assist the evaluation of existing low frequency exposure standards for the entire population under all exposure conditions.

  8. Search for contact interactions in the dielectron channel in p-p collisions at √s=8

    SciTech Connect

    Lamichhane, Pramod

    2013-01-01

    A possible explanation of mass hierarchy, which is not explained by the Standard Model, is that quarks and leptons are composite objects made of more fundamental particles known as preons. The existence of preons will be manifest as a four fermion contact interaction in the annihilation of a quark and anti-quark, in a p-p collision, producing positron-electron pairs. At high mass, such pairs are also produced from off-shell Z and γ bosons. This thesis provides a detailed discussion of the analysis strategy to study these processes using the Compact Muon Solenoid Experiment at the Large Hadron Collider. The study utilizes data recorded in 2012 at √s = 8 TeV, corresponding to an integrated luminosity of 19.6 fb-1. The dielectron mass spectrum above 300 GeV shows no significant deviation from the prediction of the Standard Model. In the framework of the left-left iso-scalar model of eeqq contact interactions, 95\\% CL lower limits on the energy scale parameter are found for destructive (13.1 TeV) and constructive (18.3 TeV) interference between the contact and standard model amplitudes. These limits are the most stringent to date.

  9. String coupling and interactions in type IIB matrix model

    SciTech Connect

    Kitazawa, Yoshihisa; Nagaoka, Satoshi

    2009-05-15

    We investigate the interactions of closed strings in a IIB matrix model. The basic interaction of the closed superstring is realized by the recombination of two intersecting strings. Such interaction is investigated in a IIB matrix model via two-dimensional noncommutative gauge theory in the IR limit. By estimating the probability of the recombination, we identify the string coupling g{sub s} in the IIB matrix model. We confirm that our identification is consistent with matrix string theory.

  10. Search for Contact Interactions in the Dimuon Channel in $pp$ Collisions at $\\sqrt{s} = 7$ TeV at CMS

    SciTech Connect

    Gollapinni, Sowjanya

    2012-01-01

    The standard model fails to explain the variety of observed quark and lepton avors and their masses suggesting that there might exist a more fundamental basis. If quarks and leptons are composite particles made up of more basic constituents, a new physics interaction in the form of a four-fermion contact interaction arises between them. Experimentally the signal is manifest as a deviation from the standard model prediction in the high-mass tail for the invariant mass distribution of the opposite-sign dimuon pairs. The Large Hadron Collider accelerator at the Center for European Nuclear Research is built to explore new physics possibilities from proton-proton collisions occurring at the world's highest center-of-mass energy. This thesis discusses in detail a search strategy for a new physics possibility based on a left-handed current model of contact interactions. Based on 5.3 fb-1 of 2011 data as collected by the Compact Muon Solenoid detector, exclusion lower limits at 95% con dence level are set on the compositeness energy scale , for both destructive and constructive interferences of the new physics with the standard model Drell-Yan process. These limits form the most stringent limits to date and exceed the current published limits signi cantly.

  11. Graphical models of protein-protein interaction specificity from correlated mutations and interaction data.

    PubMed

    Thomas, John; Ramakrishnan, Naren; Bailey-Kellogg, Chris

    2009-09-01

    Protein-protein interactions are mediated by complementary amino acids defining complementary surfaces. Typically not all members of a family of related proteins interact equally well with all members of a partner family; thus analysis of the sequence record can reveal the complementary amino acid partners that confer interaction specificity. This article develops methods for learning and using probabilistic graphical models of such residue "cross-coupling" constraints between interacting protein families, based on multiple sequence alignments and information about which pairs of proteins are known to interact. Our models generalize traditional consensus sequence binding motifs, and provide a probabilistic semantics enabling sound evaluation of the plausibility of new possible interactions. Furthermore, predictions made by the models can be explained in terms of the underlying residue interactions. Our approach supports different levels of prior knowledge regarding interactions, including both one-to-one (e.g., pairs of proteins from the same organism) and many-to-many (e.g., experimentally identified interactions), and we present a technique to account for possible bias in the represented interactions. We apply our approach in studies of PDZ domains and their ligands, fundamental building blocks in a number of protein assemblies. Our algorithms are able to identify biologically interesting cross-coupling constraints, to successfully identify known interactions, and to make explainable predictions about novel interactions.

  12. Interactive Multimedia and Model-based Learning in Biology.

    ERIC Educational Resources Information Center

    Buckley, Barbara C.

    2000-01-01

    Documents a case of model-building in biology through microanalysis of one student's interaction with "Science for Living: The Circulatory System (SFL)", an interactive multimedia resource prototype for research. Describes the student's learning goals, gains, and activities with particular attention to interactions with representations,…

  13. Mathematical Modeling of Circadian and Homeostatic Interaction

    DTIC Science & Technology

    2011-11-16

    REM ) sleep , and non- REM ( NREM ) sleep states. Using this mathematical modeling framework, the Pis conducted modeling studies on several...The model network exhibits realistic polyphasic sleep -wake behavior consisting of wake, rapid eye movement ( REM ) sleep , and non- REM ( NREM ) sleep ...states. In addition, the model captures stereotypical sleep patterning including cycling between NREM and REM sleep . Using this

  14. Biological models and statistical interactions: an example from multistage carcinogenesis.

    PubMed

    Siemiatycki, J; Thomas, D C

    1981-12-01

    From the assessment of statistical interaction between risk factors it is tempting to infer the nature of the biologic interaction between the factors. However, the use of statistical analyses of epidemiologic data to infer biologic processes can be misleading. as an example, we consider the multistage model of carcinogenesis. Under this biologic model, it is shown, by means of simple hypothetical examples, that even if carcinogenic factors act independently, some pairs may fit an additive statistical model, some a multiplicative statistical model, and some neither. The elucidation of biological interactions by means of statistical models requires the imaginative and prudent use of inductive and deductive reasoning; it cannot be done mechanically.

  15. Cyberdemocracy and Online Politics: A New Model of Interactivity

    ERIC Educational Resources Information Center

    Ferber, Paul; Foltz, Franz; Pugliese, Rudy

    2007-01-01

    Building on McMillan's two-way model of interactivity, this study presents a three-way model of interactive communication, which is used to assess political Web sites' progress toward the ideals of cyberdemocracy and the fostering of public deliberation. Results of a 3-year study of state legislature Web sites, an analysis of the community…

  16. Dynamical symmetry breaking in models with the Yukawa interaction

    SciTech Connect

    Ksenzov, V. G.; Romanov, A. I.

    2013-04-15

    The models with a massless fermion and a self-interacting massive scalar field with the Yukawa interaction are discussed. The chiral condensate and the fermion mass are calculated analytically through a one-loop approximation in (1 + 1)-dimensions. It is shown that the models have a phase transition as a function of the squared mass of the scalar field.

  17. Cyberpsychology: a human-interaction perspective based on cognitive modeling.

    PubMed

    Emond, Bruno; West, Robert L

    2003-10-01

    This paper argues for the relevance of cognitive modeling and cognitive architectures to cyberpsychology. From a human-computer interaction point of view, cognitive modeling can have benefits both for theory and model building, and for the design and evaluation of sociotechnical systems usability. Cognitive modeling research applied to human-computer interaction has two complimentary objectives: (1) to develop theories and computational models of human interactive behavior with information and collaborative technologies, and (2) to use the computational models as building blocks for the design, implementation, and evaluation of interactive technologies. From the perspective of building theories and models, cognitive modeling offers the possibility to anchor cyberpsychology theories and models into cognitive architectures. From the perspective of the design and evaluation of socio-technical systems, cognitive models can provide the basis for simulated users, which can play an important role in usability testing. As an example of application of cognitive modeling to technology design, the paper presents a simulation of interactive behavior with five different adaptive menu algorithms: random, fixed, stacked, frequency based, and activation based. Results of the simulation indicate that fixed menu positions seem to offer the best support for classification like tasks such as filing e-mails. This research is part of the Human-Computer Interaction, and the Broadband Visual Communication research programs at the National Research Council of Canada, in collaboration with the Carleton Cognitive Modeling Lab at Carleton University.

  18. Conversation as a Model of Instructional Interaction

    ERIC Educational Resources Information Center

    Van Bramer, Joan

    2003-01-01

    The role of social context and the nature of human interaction provide rich resources for the study of learning and human cognition. In order to understand these elements more fully, it is important to consider the language in use within these contexts. The early intervention Reading Recovery is grounded in the belief that the conversation between…

  19. Polymer Interaction in a Model Bioblend

    Technology Transfer Automated Retrieval System (TEKTRAN)

    EBU/PS blends of varying compositions were investigated using TGA, MDSC, and FTIR-PAS methods. The goal of the investigation was that of probing for the presence or lack of intermolecular interactions between the two polymers. The TGA investigation showed at least one blend composition with better...

  20. Developing Interactive Instructional Materials: A Model.

    ERIC Educational Resources Information Center

    Henderson, Craig; And Others

    Many colleges and departments at Tennessee Technological University, as well as most other major universities, are progressing toward more interactive instructional materials. The benefits of implementing instructional technology are numerous and diverse. However, because of increasingly austere budgets, a focused and cost-effective approach to…

  1. Turbulent Chemical Interaction Models in NCC: Comparison

    NASA Technical Reports Server (NTRS)

    Norris, Andrew T.; Liu, Nan-Suey

    2006-01-01

    The performance of a scalar PDF hydrogen-air combustion model in predicting a complex reacting flow is evaluated. In addition the results are compared to those obtained by running the same case with the so-called laminar chemistry model and also a new model based on the concept of mapping partially stirred reactor data onto perfectly stirred reactor data. The results show that the scalar PDF model produces significantly different results from the other two models, and at a significantly higher computational cost.

  2. Model for High-Speed Interaction Heating.

    DTIC Science & Technology

    1982-12-01

    confined reverse flow region. The classical Howarth boundary-layer separation calculation involves an ex- ternal flow with a linearly decreasing edge...flows separate and never re- attach. In order to circumvent this behavior, the classical Howarth example was modified by maintaining the edge velocity...113-127. 3. Golstein , S., Quart. J. Mech Appl. Math. 1, 1948, 43. 4. Wigton, L. B. and Holt, M., "Viscous-Inviscid Interaction in Transonic Flow

  3. Modeling Microbiological Interactions with Hydrothermal Flow

    NASA Technical Reports Server (NTRS)

    Hoehler, Tori

    2006-01-01

    All organisms require energy. Characterizing and quantifying the biological demand for energy places constraints on the possible interactions of organisms with each other and with the environment. This talk will consider energetic and mass transfer constraints on the ecology of hydrothermal vent microbes. Following a general introduction to the biological energy requirements and their link to environmental conditions, energy constraints will be applied to several vent-relevant case studies.

  4. Geoacoustic Physical Modeling: Volume-Roughness Interactions

    DTIC Science & Technology

    2008-09-30

    important break by showing its relationship to the angle of repose , a fundamental feature of granular sediments (such as sands)[Ivakin, 2005...significant considering the fact that the slope of roughness at sub-cm scales at SAX99 site is large and can be close to both angle of repose and...roughness interactions and should be very pronounced at near- and sub-critical grazing angles . For example, the very first theoretical considerations

  5. Interactive communication systems simulation model - ICSSM

    NASA Astrophysics Data System (ADS)

    Wade, W. D.; Mortara, M. E.; Leong, P. K.; Frost, V. S.

    1984-01-01

    The design of ICSSM, a nonreal time computer-aided simulation and analysis tool for communications systems, is presented, ICSSM is capable of supporting modeling, simulation, and analysis of any system representable in terms of a network of multiport functional blocks. Its applicability is limited only by the modeler's ingenuity to decompose the system to functional blocks and to represent these functional blocks algorithmically. ICSSM has been constructed modularly, consisting of five subsytems to facilitate the tasks of formulating the model, exercising the model, evaluating and showing the simulation results, and storing and maintaining a library of modeling elements, analysis, and utility subroutines. It is written exclusively in ANSI Standard Fortran IV language, and is now operational in a Honeywell DPS 7/80 M computer under the MULTICS Operating System. Description of a recent simulation using ICSSM and some generic modules of general interest developed as a result of the modeling work are also presented.

  6. Modeling land use interaction using linguistic variables

    NASA Astrophysics Data System (ADS)

    Karimi, Mohammad; Sharifi, Mohammad Ali; Mesgari, Mohammad Saadi

    2012-06-01

    One of the main factors of land use change (LUC) modeling is the land use intersection (LUI) or neighborhood effect, which is normally modeled using cellular automata (CA) concept. The effects of LUI over distance are represented in terms of CA transition rules. In this paper, a new model for LUI process is developed that makes use of expert knowledge to define the transition rules. In this model, the region of influence is defined using a new radial structure; the transition rules are described by expert knowledge and spatial metrics in the form of linguistic variables; and finally, the neighborhood effect is classified into three groups of compactness, dependency and incompatibility. The model is implemented and evaluated using the data of Borkhar and Meymeh township, in Esfahan, Iran, for the two periods of 1986-1998 and 1998-2005. The results show that the model and its related concept are performing rather well.

  7. The GOURD model of human-computer interaction

    SciTech Connect

    Goldbogen, G.

    1996-12-31

    This paper presents a model, the GOURD model, that can be used to measure the goodness of {open_quotes}interactivity{close_quotes} of an interface design and qualifies how to improve the design. The GOURD model describes what happens to the computer and to the human during a human-computer interaction. Since the interaction is generally repeated, the traversal of the model repeatedly is similar to a loop programming structure. Because the model measures interaction over part or all of the application, it can also be used as a classifier of the part or the whole application. But primarily, the model is used as a design guide and a predictor of effectiveness.

  8. Mathematical Modelling of Laser/Material Interactions.

    DTIC Science & Technology

    1983-11-25

    translated to the model input. Even an experimental mode print can also be digitalised for the model. In trying to describe high order modes matliematically...4. Mazumder J. Steen W.M. "Welding of Ti 6al - 4V by continuous wave CO2 laser". Metal construction Sept. 1980 pp423 - 427. 5. Kogelnik H, Li.T Proc

  9. MODELING DISPERSANT INTERACTIONS WITH OIL SPILLS

    EPA Science Inventory

    EPA is developing a model called the EPA Research Object-Oriented Oil Spill Model (ERO3S) and associated databases to simulate the impacts of dispersants on oil slicks. Because there are features of oil slicks that align naturally with major concepts of object-oriented programmi...

  10. Effective Interactions from No Core Shell Model

    SciTech Connect

    Dikmen, E.; Lisetskiy, A. F.; Barrett, B. R.; Navratil, P.; Vary, J. P.

    2008-11-11

    We construct the many-body effective Hamiltonian for pf-shell by carrying out 2({Dirac_h}/2{pi}){omega}. NCSM calculations at the 2-body cluster level. We demonstrate how the effective Hamiltonian derived from realistic nucleon-nucleon (NN) potentials for the 2({Dirac_h}/2{pi}){omega} NCSM space should be modified to properly account for the many-body correlations produced by truncating to the major pf-shell. We obtain two-body effective interactions for the pf-shell by using direct projection and use them to reproduce the results of large scale NCSM for other light Ca isotopes.

  11. Interactive model building for Q-learning.

    PubMed

    Laber, Eric B; Linn, Kristin A; Stefanski, Leonard A

    2014-10-20

    Evidence-based rules for optimal treatment allocation are key components in the quest for efficient, effective health care delivery. Q-learning, an approximate dynamic programming algorithm, is a popular method for estimating optimal sequential decision rules from data. Q-learning requires the modeling of nonsmooth, nonmonotone transformations of the data, complicating the search for adequately expressive, yet parsimonious, statistical models. The default Q-learning working model is multiple linear regression, which is not only provably misspecified under most data-generating models, but also results in nonregular regression estimators, complicating inference. We propose an alternative strategy for estimating optimal sequential decision rules for which the requisite statistical modeling does not depend on nonsmooth, nonmonotone transformed data, does not result in nonregular regression estimators, is consistent under a broader array of data-generation models than Q-learning, results in estimated sequential decision rules that have better sampling properties, and is amenable to established statistical approaches for exploratory data analysis, model building, and validation. We derive the new method, IQ-learning, via an interchange in the order of certain steps in Q-learning. In simulated experiments IQ-learning improves on Q-learning in terms of integrated mean squared error and power. The method is illustrated using data from a study of major depressive disorder.

  12. INFUSION: Modeling Robot and Crew Interaction

    NASA Technical Reports Server (NTRS)

    Laufenberg, Lawrence

    2003-01-01

    Brahms is a multi-agent modeling and simulation language and distributed runtime system developed at NASA. It can be used to model and run a simualtion of the distributed work activities of multiple agents, such as humans,robots, and software agents, to coordinate a mission on one or more locations.Brahms is being used to model activities at the Flashline Man Arctic Research Station for possible use in planning Mars missions. The station is located at Haughton Crater, Devon Island, Nutiavut, Arctic Canada.

  13. Modelling refractive index changes due to molecular interactions

    NASA Astrophysics Data System (ADS)

    Varma, Manoj

    2016-03-01

    There are a large number of sensing techniques which use optical changes to monitor interactions between molecules. In the absence of fluorophores or other labels, the basic signal transduction mechanism relies on refractive index changes arising from the interactions of the molecules involved. A quantitative model incorporating molecular transport, reaction kinetics and optical mixing is presented which reveals important insights concerning the optimal detection of molecular interactions optically. Although conceptually simple, a comprehensive model such as this has not been reported anywhere. Specifically, we investigate the pros and cons of detecting molecular interactions in free solution relative to detecting molecular interactions on surfaces using surface bound receptor molecules such as antibodies. The model reveals that the refractive index change produced in surface based sensors is 2-3 orders of magnitude higher than that from interactions in free solution. On the other hand, the model also reveals that it is indeed possible to distinguish specific molecular interactions from non-specific ones based on free-solution bulk refractometry without any washing step necessary in surface based sensors. However, the refractive index change for free solution interactions predicted by the model is smaller than 10-7 RIU, even for large proteins such as IgG in sufficiently high concentrations. This value is smaller than the typical 10-6 RIU detection limit of most state of the art optical sensing techniques therefore requiring techniques with substantially higher index sensitivity such as Back Scattering Interferometry.

  14. Ferromagnetic interaction model of activity level in workplace communication

    NASA Astrophysics Data System (ADS)

    Akitomi, Tomoaki; Ara, Koji; Watanabe, Jun-ichiro; Yano, Kazuo

    2013-03-01

    The nature of human-human interaction, specifically, how people synchronize with each other in multiple-participant conversations, is described by a ferromagnetic interaction model of people’s activity levels. We found two microscopic human interaction characteristics from a real-environment face-to-face conversation. The first characteristic is that people quite regularly synchronize their activity level with that of the other participants in a conversation. The second characteristic is that the degree of synchronization increases as the number of participants increases. Based on these microscopic ferromagnetic characteristics, a “conversation activity level” was modeled according to the Ising model. The results of a simulation of activity level based on this model well reproduce macroscopic experimental measurements of activity level. This model will give a new insight into how people interact with each other in a conversation.

  15. Modeling Type-IIn Interacting Supernovae

    NASA Astrophysics Data System (ADS)

    McDowell, Austin; Duffell, Paul; Kasen, Daniel

    2017-01-01

    Spectra of Type-IIn Supernovae (SNe) have shown evidence of interaction between SN ejecta and a surrounding circumstellar medium (CSM). Namely, narrow Hydrogen lines indicate that the fast moving ejecta slows after it collides with the slow moving CSM. However, observations of eta-Carinae and spectropolarimetry of SN2009ip during its 2012 explosion have shown that the CSM may often be asymmetric. In this study, we investigate the ability of an asymmetric CSM to disguise the characteristic narrow H lines expected from Type-IIn SNe. We perform two-dimensional hydrodynamic simulations of the interaction between supernova ejecta and CSM. The simulations are run using the moving-mesh hydrodynamics code JET. Previous studies have ignored possible asymmetries by limiting their calculations to one-dimension or assuming a spherically symmetric CSM. We calculate shock propagation within the disk and CSM heating rate to produce mock-bolometric light curves. We also track unshocked CSM mass and speculate on its effects on the observation of H lines.

  16. Model Compound Interactions Characterizing Aquatic Humic Substances

    DTIC Science & Technology

    1990-01-01

    Isolation...............48 3.3.2 Titration Apparatus..............49 3.3.3 Potentiometric Titrations ..........52 3.3.4 Complexometric Titrations ...Potentiometric Titrations ..........57 4.2.2 Complexometric Titrations ..........61 4.3 Natural Sources and Model Compound Mixtures . .. 69 4.3.1...groundwater ........ .................... 50 3.4 Milli-Q complexometric titrations ... ......... .54 4.1a Potentiometric titration of model compounds

  17. Supersonic jet and crossflow interaction: Computational modeling

    NASA Astrophysics Data System (ADS)

    Hassan, Ez; Boles, John; Aono, Hikaru; Davis, Douglas; Shyy, Wei

    2013-02-01

    The supersonic jet-in-crossflow problem which involves shocks, turbulent mixing, and large-scale vortical structures, requires special treatment for turbulence to obtain accurate solutions. Different turbulence modeling techniques are reviewed and compared in terms of their performance in predicting results consistent with the experimental data. Reynolds-averaged Navier-Stokes (RANS) models are limited in prediction of fuel structure due to their inability to accurately capture unsteadiness in the flow. Large eddy simulation (LES) is not yet practical due to prohibitively large grid requirement near the wall. Hybrid RANS/LES can offer reasonable compromise between accuracy and efficiency. The hybrid models are based on various approaches such as explicit blending of RANS and LES, detached eddy simulation (DES), and filter-based multi-scale models. In particular, they can be used to evaluate the turbulent Schmidt number modeling techniques used in jet-in-crossflow simulations. Specifically, an adaptive approach can be devised by utilizing the information obtained from the resolved field to help assign the value of turbulent Schmidt number in the sub-filter field. The adaptive approach combined with the multi-scale model improves the results especially when highly refined grids are needed to resolve small structures involved in the mixing process.

  18. Approaches to modelling hydrology and ecosystem interactions

    NASA Astrophysics Data System (ADS)

    Silberstein, Richard P.

    2014-05-01

    As the pressures of industry, agriculture and mining on groundwater resources increase there is a burgeoning un-met need to be able to capture these multiple, direct and indirect stresses in a formal framework that will enable better assessment of impact scenarios. While there are many catchment hydrological models and there are some models that represent ecological states and change (e.g. FLAMES, Liedloff and Cook, 2007), these have not been linked in any deterministic or substantive way. Without such coupled eco-hydrological models quantitative assessments of impacts from water use intensification on water dependent ecosystems under changing climate are difficult, if not impossible. The concept would include facility for direct and indirect water related stresses that may develop around mining and well operations, climate stresses, such as rainfall and temperature, biological stresses, such as diseases and invasive species, and competition such as encroachment from other competing land uses. Indirect water impacts could be, for example, a change in groundwater conditions has an impact on stream flow regime, and hence aquatic ecosystems. This paper reviews previous work examining models combining ecology and hydrology with a view to developing a conceptual framework linking a biophysically defensable model that combines ecosystem function with hydrology. The objective is to develop a model capable of representing the cumulative impact of multiple stresses on water resources and associated ecosystem function.

  19. Modeling of particle interactions in magnetorheological elastomers

    SciTech Connect

    Biller, A. M. Stolbov, O. V. Raikher, Yu. L.

    2014-09-21

    The interaction between two particles made of an isotropic linearly polarizable magnetic material and embedded in an elastomer matrix is studied. In this case, when an external field is imposed, the magnetic attraction of the particles, contrary to point dipoles, is almost wraparound. The exact solution of the magnetic problem in the linear polarization case, although existing, is not practical; to circumvent its use, an interpolation formula is proposed. One more interpolation expression is developed for the resistance of the elastic matrix to the field-induced particle displacements. Minimization of the total energy of the pair reveals its configurational bistability in a certain field range. One of the possible equilibrium states corresponds to the particles dwelling at a distance, the other—to their collapse in a tight dimer. This mesoscopic bistability causes magnetomechanical hysteresis which has important implications for the macroscopic behavior of magnetorheological elastomers.

  20. One-Dimensional Ising Model with "k"-Spin Interactions

    ERIC Educational Resources Information Center

    Fan, Yale

    2011-01-01

    We examine a generalization of the one-dimensional Ising model involving interactions among neighbourhoods of "k" adjacent spins. The model is solved by exploiting a connection to an interesting computational problem that we call ""k"-SAT on a ring", and is shown to be equivalent to the nearest-neighbour Ising model in the absence of an external…

  1. Self-consistent Models of Strong Interaction with Chiral Symmetry

    DOE R&D Accomplishments Database

    Nambu, Y.; Pascual, P.

    1963-04-01

    Some simple models of (renormalizable) meson-nucleon interaction are examined in which the nucleon mass is entirely due to interaction and the chiral ( gamma {sub 5}) symmetry is "broken'' to become a hidden symmetry. It is found that such a scheme is possible provided that a vector meson is introduced as an elementary field. (auth)

  2. Bilingual Lexical Interactions in an Unsupervised Neural Network Model

    ERIC Educational Resources Information Center

    Zhao, Xiaowei; Li, Ping

    2010-01-01

    In this paper we present an unsupervised neural network model of bilingual lexical development and interaction. We focus on how the representational structures of the bilingual lexicons can emerge, develop, and interact with each other as a function of the learning history. The results show that: (1) distinct representations for the two lexicons…

  3. Modeling Group Interactions via Open Data Sources

    DTIC Science & Technology

    2011-08-30

    data. The state-of-art search engines are designed to help general query-specific search and not suitable for finding disconnected online groups. The...groups, (2) developing innovative mathematical and statistical models and efficient algorithms that leverage existing search engines and employ

  4. Models: Electric and Magnetic Interactions, Teacher's Guide.

    ERIC Educational Resources Information Center

    Karplus, Robert

    The unit presented in this teacher's guide is one of two developed for the sixth and final year in the Science Curriculum Improvement Study (SCIS) curriculum. The concept of a scientific model is introduced in this unit with activities directed toward increasing student understanding of electric and magnetic phenomena through concrete experience…

  5. An Integrative-Interactive Conceptual Model for Curriculum Development.

    ERIC Educational Resources Information Center

    Al-Ibrahim, Abdul Rahman H.

    1982-01-01

    The Integrative-Interactive Conceptual Model for Curriculum Development calls for curriculum reform and innovation to be cybernetic so that all aspects of curriculum planning get adequate attention. (CJ)

  6. Application of large eddy interaction model to a mixing layer

    NASA Technical Reports Server (NTRS)

    Murthy, S. N. B.

    1989-01-01

    The large eddy interaction model (LEIM) is a statistical model of turbulence based on the interaction of selected eddies with the mean flow and all of the eddies in a turbulent shear flow. It can be utilized as the starting point for obtaining physical structures in the flow. The possible application of the LEIM to a mixing layer formed between two parallel, incompressible flows with a small temperature difference is developed by invoking a detailed similarity between the spectra of velocity and temperature.

  7. Membrane–drug interactions studied using model membrane systems

    PubMed Central

    Knobloch, Jacqueline; Suhendro, Daniel K.; Zieleniecki, Julius L.; Shapter, Joseph G.; Köper, Ingo

    2015-01-01

    The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins. PMID:26586998

  8. Phase space analysis of some interacting Chaplygin gas models

    NASA Astrophysics Data System (ADS)

    Khurshudyan, M.; Myrzakulov, R.

    2017-02-01

    In this paper we discuss a phase space analysis of various interacting Chaplygin gas models in general relativity. Linear and nonlinear sign changeable interactions are considered. For each case appropriate late time attractors of field equations are found. The Chaplygin gas is one of the dark fluids actively considered in modern cosmology due to the fact that it is a joint model of dark energy and dark matter.

  9. Pluto: Modeling of 3-D Atmosphere-Surface Interactions

    NASA Astrophysics Data System (ADS)

    Michaels, Timothy I.

    2015-11-01

    Atmosphere-surface interactions on Pluto are of great importance to creating and maintaining the atmospheric variations and heterogeneous surface that have been observed by New Horizons and two decades' prior work. Publicly released images/data from New Horizons contain numerous fascinating surface features and constrasts. Insights into their origin, maintenance, and/or evolution may be gleaned through multidisciplinary climate modeling. Some results from such modeling will be presented, with an emphasis on shorter-timescale interactions.

  10. Building Interdisciplinary Research Models through Interactive Education

    PubMed Central

    Hessels, Amanda; Robinson, Brian; O’Rourke, Michael; Begg, Melissa D.; Larson, Elaine

    2015-01-01

    Background Critical interdisciplinary research skills include effective communication with diverse disciplines and cultivating collaborative relationships. Acquiring these skills during graduate education may foster future interdisciplinary research quality and productivity. Objective The project aim was to develop and evaluate an interactive Toolbox workshop approach within an inter-professional graduate level course to enhance student learning and skill in interdisciplinary research. We sought to examine the student experience of integrating the Toolbox workshop in modular format over the duration of a 14 week course. Methods The Toolbox Health Sciences Instrument includes six modules that were introduced in a 110-minute dialogue session during the first class and then integrated into the course in a series of six individual workshops in three phases over the course of the semester. Results Seventeen students participated; the majority were nursing students. Three measures were used to assess project outcomes: pre-post intervention Toolbox survey, competency self-assessment and a post-course survey. All measures indicated the objectives were met by a change in survey responses, improved competencies and favorable experience of the Toolbox modular intervention. Conclusion Our experience indicates that incorporating this Toolbox modular approach into research curricula can enhance individual level scientific capacity, future interdisciplinary research project success, and ultimately impact on practice and policy. PMID:26636555

  11. Turbulence modeling in shock wave/turbulent boundary layer interactions

    NASA Technical Reports Server (NTRS)

    Smits, A. J.

    1992-01-01

    The research performed was an experimental program to help develop turbulence models for shock wave boundary layer interactions. The measurements were taken in a Mach 3, 16 deg compression corner interaction, at a unit Reynolds number of 63 x 10(exp 6)/m. The data consisted of heat transfer data taken upstream and downstream of the interaction, hot wire measurements of the instantaneous temperature and velocity fluctuations to verify the Strong Reynolds Analogy, and single- and double-pulsed Rayleigh scattering images to study the development of the instantaneous shock/turbulence interaction.

  12. Improved simulation of groundwater - surface water interaction in catchment models

    NASA Astrophysics Data System (ADS)

    teklesadik, aklilu; van Griensven, Ann; Anibas, Christian; Huysmans, Marijke

    2016-04-01

    Groundwater storage can have a significant contribution to stream flow, therefore a thorough understanding of the groundwater surface water interaction is of prime important when doing catchment modeling. The aim of this study is to improve the simulation of groundwater - surface water interaction in a catchment model of the upper Zenne River basin located in Belgium. To achieve this objective we used the "Groundwater-Surface water Flow" (GSFLOW) modeling software, which is an integration of the surface water modeling tool "Precipitation and Runoff Modeling system" (PRMS) and the groundwater modeling tool MODFLOW. For this case study, the PRMS model and MODFLOW model were built and calibrated independently. The PRMS upper Zenne River basin model is divided into 84 hydrological response units (HRUs) and is calibrated with flow data at the Tubize gauging station. The spatial discretization of the MODFLOW upper Zenne groundwater flow model consists of 100m grids. Natural groundwater divides and the Brussels-Charleroi canal are used as boundary conditions for the MODFLOW model. The model is calibrated using piezometric data. The GSFLOW results were evaluated against a SWAT model application and field observations of groundwater-surface water interactions along a cross section of the Zenne River and riparian zone. The field observations confirm that there is no exchange of groundwater beyond the Brussel-Charleroi canal and that the interaction at the river bed is relatively low. The results show that there is a significant difference in the groundwater simulations when using GSFLOW versus SWAT. This indicates that the groundwater component representation in the SWAT model could be improved and that a more realistic implementation of the interactions between groundwater and surface water is advisable. This could be achieved by integrating SWAT and MODFLOW.

  13. Modeling of high power laser interaction with metals

    NASA Astrophysics Data System (ADS)

    Mustafa, Kurt; Zahide, Demircioǧlu

    2017-02-01

    Laser matter interaction has been very popular subject from the first recognition of lasers. Laser application in industry or laboratory applications are based on definite interactions of the laser beam with the workpiece. In this paper, an effective model related with high power radiation interaction with metals is presented. In metals, Lorentz-Drude model is used calculate permeability theoretically. The plasma frequency was calculated at various temperatures and using the obtained results the refractive index of the metal (Ag) was investigated. The calculation result revealed that the effect of the temperature need to be considered at reflection and transmission of the laser beam.

  14. Modeling the interaction of ultrasound with pores

    NASA Technical Reports Server (NTRS)

    Lu, Yichi; Wadley, Haydn N. G.; Parthasarathi, Sanjai

    1991-01-01

    Factors that affect ultrasonic velocity sensing of density during consolidation of metal powders are examined. A comparison is made between experimental results obtained during the final stage of densification and the predictions of models that assume either a spherical or a spheroidal pore shape. It is found that for measurements made at low frequencies during the final stage of densification, relative density (pore fraction) and pore shape are the two most important factors determining the ultrasonic velocity, the effect of pore size is negligible.

  15. Modeling of Interactions of Ablated Plumes

    DTIC Science & Technology

    2008-02-01

    C). B. The governing equations and the numerical method The developed model is based on the compressible two-species Euler and Navier - Stokes equations ...heat transfer at 20 km are obtained by solving the inviscid Euler and viscous Navier - Stokes equations (see Fig. 2). Note that in this and subsequent...altitude 20kmn: a-b) plume concentration -t 45l) and c-d) heat transfer coefficient, where a,c) Euler equations and b,d) Navier - Stokes equations . III

  16. Element-specific density profiles in interacting biomembrane models

    NASA Astrophysics Data System (ADS)

    Schneck, Emanuel; Rodriguez-Loureiro, Ignacio; Bertinetti, Luca; Marin, Egor; Novikov, Dmitri; Konovalov, Oleg; Gochev, Georgi

    2017-03-01

    Surface interactions involving biomembranes, such as cell–cell interactions or membrane contacts inside cells play important roles in numerous biological processes. Structural insight into the interacting surfaces is a prerequisite to understand the interaction characteristics as well as the underlying physical mechanisms. Here, we work with simplified planar experimental models of membrane surfaces, composed of lipids and lipopolymers. Their interaction is quantified in terms of pressure–distance curves using ellipsometry at controlled dehydrating (interaction) pressures. For selected pressures, their internal structure is investigated by standing-wave x-ray fluorescence (SWXF). This technique yields specific density profiles of the chemical elements P and S belonging to lipid headgroups and polymer chains, as well as counter-ion profiles for charged surfaces.

  17. Interaction field modeling of mini-UAV swarm

    NASA Astrophysics Data System (ADS)

    Liou, William W.; Ro, Kapseong; Szu, Harold

    2006-05-01

    A behavior-based, simple interaction model inspired by molecular interaction field depicted by the Lennard-Jones function is examined for the averaged interaction in swarming. The modeled kinematic equation of motion contains only one variable, instead of a multiple state variable dependence a more complete dynamics entails. The model assumes a spatial distribution of the potential associate with the swarm. The model has been applied to examine the formation of swarm and the results are reported. The modeling can be reflected in an equilibrium theory for the operation of a swarm of mini-UAVs pioneered by Szu, where every member serves the mission while exploiting other's loss, resulting in a zero-sum game among the team members.

  18. New generation of exploration tools: interactive modeling software and microcomputers

    SciTech Connect

    Krajewski, S.A.

    1986-08-01

    Software packages offering interactive modeling techniques are now available for use on microcomputer hardware systems. These packages are reasonably priced for both company and independent explorationists; they do not require users to have high levels of computer literacy; they are capable of rapidly completing complex ranges of sophisticated geologic and geophysical modeling tasks; and they can produce presentation-quality output for comparison with real-world data. For example, interactive packages are available for mapping, log analysis, seismic modeling, reservoir studies, and financial projects as well as for applying a variety of statistical and geostatistical techniques to analysis of exploration data. More importantly, these packages enable explorationists to directly apply their geologic expertise when developing and fine-tuning models for identifying new prospects and for extending producing fields. As a result of these features, microcomputers and interactive modeling software are becoming common tools in many exploration offices. Gravity and magnetics software programs illustrate some of the capabilities of such exploration tools.

  19. Predicting genetic interactions from Boolean models of biological networks.

    PubMed

    Calzone, Laurence; Barillot, Emmanuel; Zinovyev, Andrei

    2015-08-01

    Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. We describe a computational methodology allowing us to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. We use the probabilistic framework defined in MaBoSS software, based on continuous time Markov chains and stochastic simulations. In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. We classify the obtained interactions according to their class of epistasis, dependence on the chosen initial conditions and the phenotype. The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed.

  20. Two-dimensional XXZ-Ising model with quartic interactions.

    PubMed

    Valverde, J S

    2012-05-01

    In this work we study a two-dimensional XXZ-Ising spin-1/2 model with quartic interactions. The model is composed of a two-dimensional lattice of edge-sharing unitary cells, where each cell consists of two triangular prisms, converging in a basal plane with four Ising spin-1/2 (open circles); the apical positions are also occupied by four Heisenberg spin-1/2 (solid circles). Interaction of the base plane containing the multispin Ising interaction has the parameter J_{4}, and the other pairwise interactions have parameter J. For the proposed model we construct the phase diagram at zero temperature and give all possible spin configurations. In addition, we investigate two regions where the model can be solved exactly, the free fermion condition (FFC) and the symmetrical eight-vertex condition (SEVC). For this purpose we perform a straightforward mapping for a zero-field eight-vertex model. The necessary conditions for the equivalence are analyzed for all ranges of the interaction parameters. Unfortunately, the present model does not satisfy the FFC unless the trivial case; however, it was possible to give a region where the model can be solved approximately. We study the SEVC and verify that this condition is always satisfied. We also explore and discuss the critical conditions giving the region where these critical points are relevant.

  1. Towards a Revised Monte Carlo Neutral Particle Surface Interaction Model

    SciTech Connect

    D.P. Stotler

    2005-06-09

    The components of the neutral- and plasma-surface interaction model used in the Monte Carlo neutral transport code DEGAS 2 are reviewed. The idealized surfaces and processes handled by that model are inadequate for accurately simulating neutral transport behavior in present day and future fusion devices. We identify some of the physical processes missing from the model, such as mixed materials and implanted hydrogen, and make some suggestions for improving the model.

  2. Modeling Human Dynamics of Face-to-Face Interaction Networks

    NASA Astrophysics Data System (ADS)

    Starnini, Michele; Baronchelli, Andrea; Pastor-Satorras, Romualdo

    2013-04-01

    Face-to-face interaction networks describe social interactions in human gatherings, and are the substrate for processes such as epidemic spreading and gossip propagation. The bursty nature of human behavior characterizes many aspects of empirical data, such as the distribution of conversation lengths, of conversations per person, or of interconversation times. Despite several recent attempts, a general theoretical understanding of the global picture emerging from data is still lacking. Here we present a simple model that reproduces quantitatively most of the relevant features of empirical face-to-face interaction networks. The model describes agents that perform a random walk in a two-dimensional space and are characterized by an attractiveness whose effect is to slow down the motion of people around them. The proposed framework sheds light on the dynamics of human interactions and can improve the modeling of dynamical processes taking place on the ensuing dynamical social networks.

  3. Shock Particle Interaction - Fully Resolved Simulations and Modeling

    NASA Astrophysics Data System (ADS)

    Mehta, Yash; Neal, Chris; Jackson, Thomas L.; Balachandar, S. "Bala"; Thakur, Siddharth

    2016-11-01

    Currently there is a substantial lack of fully resolved data for shock interacting with multiple particles. In this talk we will fill this gap by presenting results of shock interaction with 1-D array and 3-D structured arrays of particles. Objectives of performing fully resolved simulations of shock propagation through packs of multiple particles are twofold, 1) To understand the complicated physical phenomena occurring during shock particle interaction, and 2) To translate the knowledge from microscale simulations in building next generation point-particle models for macroscale simulations that can better predict the motion (forces) and heat transfer for particles. We compare results from multiple particle simulations against the single particle simulations and make relevant observations. The drag history and flow field for multiple particle simulations are markedly different from those of single particle simluations, highlighting the effect of neighboring particles. We propose new models which capture this effect of neighboring particles. These models are called Pair-wise Interaction Extended Point Particle models (PIEP). Effect of multiple neighboring particles is broken down into pair-wise interactions, and these pair-wise interactions are superimposed to get the final model U.S. Department of Energy, National Nuclear Security Administration, Advanced Simulation and Computing Program, as a Cooperative Agreement under the Predictive Science Academic Alliance Program, under Contract No. DE-NA0002378.

  4. Galaxy Zoo: Mergers - Dynamical models of interacting galaxies

    NASA Astrophysics Data System (ADS)

    Holincheck, Anthony J.; Wallin, John F.; Borne, Kirk; Fortson, Lucy; Lintott, Chris; Smith, Arfon M.; Bamford, Steven; Keel, William C.; Parrish, Michael

    2016-06-01

    The dynamical history of most merging galaxies is not well understood. Correlations between galaxy interaction and star formation have been found in previous studies, but require the context of the physical history of merging systems for full insight into the processes that lead to enhanced star formation. We present the results of simulations that reconstruct the orbit trajectories and disturbed morphologies of pairs of interacting galaxies. With the use of a restricted three-body simulation code and the help of citizen scientists, we sample 105 points in parameter space for each system. We demonstrate a successful recreation of the morphologies of 62 pairs of interacting galaxies through the review of more than 3 million simulations. We examine the level of convergence and uniqueness of the dynamical properties of each system. These simulations represent the largest collection of models of interacting galaxies to date, providing a valuable resource for the investigation of mergers. This paper presents the simulation parameters generated by the project. They are now publicly available in electronic format at http://data.galaxyzoo.org/mergers.html. Though our best-fitting model parameters are not an exact match to previously published models, our method for determining uncertainty measurements will aid future comparisons between models. The dynamical clocks from our models agree with previous results of the time since the onset of star formation from starburst models in interacting systems and suggest that tidally induced star formation is triggered very soon after closest approach.

  5. A random interacting network model for complex networks

    PubMed Central

    Goswami, Bedartha; Shekatkar, Snehal M.; Rheinwalt, Aljoscha; Ambika, G.; Kurths, Jürgen

    2015-01-01

    We propose a RAndom Interacting Network (RAIN) model to study the interactions between a pair of complex networks. The model involves two major steps: (i) the selection of a pair of nodes, one from each network, based on intra-network node-based characteristics, and (ii) the placement of a link between selected nodes based on the similarity of their relative importance in their respective networks. Node selection is based on a selection fitness function and node linkage is based on a linkage probability defined on the linkage scores of nodes. The model allows us to relate within-network characteristics to between-network structure. We apply the model to the interaction between the USA and Schengen airline transportation networks (ATNs). Our results indicate that two mechanisms: degree-based preferential node selection and degree-assortative link placement are necessary to replicate the observed inter-network degree distributions as well as the observed inter-network assortativity. The RAIN model offers the possibility to test multiple hypotheses regarding the mechanisms underlying network interactions. It can also incorporate complex interaction topologies. Furthermore, the framework of the RAIN model is general and can be potentially adapted to various real-world complex systems. PMID:26657032

  6. Coexistence of interacting opinions in a generalized Sznajd model

    NASA Astrophysics Data System (ADS)

    Timpanaro, André M.; Prado, Carmen P. C.

    2011-08-01

    The Sznajd model is a sociophysics model that mimics the propagation of opinions in a closed society, where the interactions favor groups of agreeing people. It is based in the Ising and Potts ferromagnetic models and, although the original model used only linear chains, it has since been adapted to general networks. This model has a very rich transient, which has been used to model several aspects of elections, but its stationary states are always consensus states. In order to model more complex behaviors, we have, in a recent work, introduced the idea of biases and prejudices to the Sznajd model by generalizing the bounded confidence rule, which is common to many continuous opinion models, to what we called confidence rules. In that work we have found that the mean field version of this model (corresponding to a complete network) allows for stationary states where noninteracting opinions survive, but never for the coexistence of interacting opinions. In the present work, we provide networks that allow for the coexistence of interacting opinions for certain confidence rules. Moreover, we show that the model does not become inactive; that is, the opinions keep changing, even in the stationary regime. This is an important result in the context of understanding how a rule that breeds local conformity is still able to sustain global diversity while avoiding a frozen stationary state. We also provide results that give some insights on how this behavior approaches the mean field behavior as the networks are changed.

  7. Reduced-order models for vertical human-structure interaction

    NASA Astrophysics Data System (ADS)

    Van Nimmen, Katrien; Lombaert, Geert; De Roeck, Guido; Van den Broeck, Peter

    2016-09-01

    For slender and lightweight structures, the vibration serviceability under crowd- induced loading is often critical in design. Currently, designers rely on equivalent load models, upscaled from single-person force measurements. Furthermore, it is important to consider the mechanical interaction with the human body as this can significantly reduce the structural response. To account for these interaction effects, the contact force between the pedestrian and the structure can be modelled as the superposition of the force induced by the pedestrian on a rigid floor and the force resulting from the mechanical interaction between the structure and the human body. For the case of large crowds, however, this approach leads to models with a very high system order. In the present contribution, two equivalent reduced-order models are proposed to approximate the dynamic behaviour of the full-order coupled crowd-structure system. A numerical study is performed to evaluate the impact of the modelling assumptions on the structural response to pedestrian excitation. The results show that the full-order moving crowd model can be well approximated by a reduced-order model whereby the interaction with the pedestrians in the crowd is modelled using a single (equivalent) SDOF system.

  8. Cluster variation studies of the anisotropic exchange interaction model

    NASA Astrophysics Data System (ADS)

    King, T. C.; Chen, H. H.

    The cluster variation method is applied to study critical properties of the Potts-like ferromagnetic anisotropic exchange interaction model. Phase transition temperatures, order parameter discontinuities and latent heats of the model on the triangular and the fcc lattices are determined by the triangle approximation; and those on the square and the sc lattices are determined by the square approximation.

  9. Evaluating Differential Effects Using Regression Interactions and Regression Mixture Models

    ERIC Educational Resources Information Center

    Van Horn, M. Lee; Jaki, Thomas; Masyn, Katherine; Howe, George; Feaster, Daniel J.; Lamont, Andrea E.; George, Melissa R. W.; Kim, Minjung

    2015-01-01

    Research increasingly emphasizes understanding differential effects. This article focuses on understanding regression mixture models, which are relatively new statistical methods for assessing differential effects by comparing results to using an interactive term in linear regression. The research questions which each model answers, their…

  10. Systematic Uncertainties in High-Energy Hadronic Interaction Models

    NASA Astrophysics Data System (ADS)

    Zha, M.; Knapp, J.; Ostapchenko, S.

    2003-07-01

    Hadronic interaction models for cosmic ray energies are uncertain since our knowledge of hadronic interactions is extrap olated from accelerator experiments at much lower energies. At present most high-energy models are based on Grib ov-Regge theory of multi-Pomeron exchange, which provides a theoretical framework to evaluate cross-sections and particle production. While experimental data constrain some of the model parameters, others are not well determined and are therefore a source of systematic uncertainties. In this paper we evaluate the variation of results obtained with the QGSJET model, when modifying parameters relating to three ma jor sources of uncertainty: the form of the parton structure function, the role of diffractive interactions, and the string hadronisation. Results on inelastic cross sections, on secondary particle production and on the air shower development are discussed.

  11. Interactive Documentary: A Production Model for Nonfiction Multimedia Narratives

    NASA Astrophysics Data System (ADS)

    Choi, Insook

    This paper presents an interactive production model for nonfiction multimedia, referred to as interactive documentary. We discuss the design of ontologies for authoring interactive documentary. A working prototype supports the use of reasoning for retrieving, composing, and displaying media resources in real-time. A GUI is designed to facilitate concept-based navigation which enables queries across media resources of diverse types. A dual-root-node data design links ontological reasoning with metadata, which provides a method for defining hybrid semantic-quantitative relationships. Our application focuses on archiving and retrieving non-text based media resources. The system architecture supports sensory-rich display feedback with real time interactivity for navigating documents’ space. We argue an experience of narratives evolves through the performitivity in the interactive narrative structure when the constituents are mediated by common ontology. The consequential experience identifies a renewed practice of oral tradition where the accumulative sensorial propositions inform narratives, such as in performance practice.

  12. Dense gaps in the interacting Aubry-André model

    NASA Astrophysics Data System (ADS)

    Mastropietro, Vieri

    2016-06-01

    We consider the interacting Aubry-André model describing fermions on a one-dimensional lattice with an incommensurate potential and a short-range many-body interaction. The single-particle spectrum has infinitely many gaps in the extended phase and at zero temperature is an insulator for almost all the chemical potentials. The many-body interaction has the effect that the gaps are strongly decreased or increased depending on the attractive or repulsive nature of the interaction, but even the smallest gaps remain open. The system is a band insulator for generic chemical potentials even in the presence of interaction, and a quantum phase transition is excluded at weak coupling.

  13. A Pairwise Preferential Interaction Model for Understanding Peptide Aggregation

    PubMed Central

    Kang, Myungshim

    2010-01-01

    A pairwise preferential interaction model (PPIM), based on Kirkwood–Buff integrals, is developed to quantify and characterize the interactions between some of the functional groups commonly observed in peptides. The existing experimental data are analyzed to determine the preferential interaction (PI) parameters for different amino acid and small peptide systems in aqueous solutions. The PIs between the different functional groups present in the peptides are then isolated and quantified by assuming simple pairwise additivity. The PPIM approach provides consistent estimates for the pair interactions between the same functional groups obtained from different solute molecules. Furthermore, these interactions appear to be chemically intuitive. It is argued that this type of approach can provide valuable information concerning specific functional group correlations which could give rise to peptide aggregation. PMID:20694045

  14. An interaction model for visualizations beyond the desktop.

    PubMed

    Jansen, Yvonne; Dragicevic, Pierre

    2013-12-01

    We present an interaction model for beyond-desktop visualizations that combines the visualization reference model with the instrumental interaction paradigm. Beyond-desktop visualizations involve a wide range of emerging technologies such as wall-sized displays, 3D and shape-changing displays, touch and tangible input, and physical information visualizations. While these technologies allow for new forms of interaction, they are often studied in isolation. New conceptual models are needed to build a coherent picture of what has been done and what is possible. We describe a modified pipeline model where raw data is processed into a visualization and then rendered into the physical world. Users can explore or change data by directly manipulating visualizations or through the use of instruments. Interactions can also take place in the physical world outside the visualization system, such as when using locomotion to inspect a large scale visualization. Through case studies we illustrate how this model can be used to describe both conventional and unconventional interactive visualization systems, and compare different design alternatives.

  15. Modeling of Needle-Tissue Interaction Forces During Surgical Suturing

    PubMed Central

    Jackson, Russell C.; Çavuşoğlu, M. Cenk

    2013-01-01

    This paper presents a model of needle tissue interaction forces that a rigid suture needle experiences during surgical suturing. The needle-tissue interaction forces are modeled as the sum of lumped parameters. The model has three main components; friction, tissue compression, and cutting forces. The tissue compression force uses the area that the needle sweeps out during a suture to estimate both the force magnitude and force direction. The area that the needle sweeps out is a direct result of driving the needle in a way that does not follow the natural curve of the needle. The friction force is approximated as a static friction force along the shaft of the needle. The cutting force acts only on the needle tip. The resulting force and torque model is experimentally validated using a tissue phantom. These results indicate that the proposed lumped parameter model is capable of accurately modeling the forces experienced during a suture. PMID:24683499

  16. Towards an integrated molecular model of plant-virus interactions.

    PubMed

    Elena, Santiago F; Rodrigo, Guillermo

    2012-12-01

    The application in recent years of network theory methods to the study of host-virus interactions is providing a new perspective to the way viruses manipulate the host to promote their own replication. An integrated molecular model of such pathosystems require three detailed maps describing, firstly, the interactions between viral elements, secondly, the interactions between host elements, and thirdly, the cross-interactions between viral and host elements. Here, we compile available information for Potyvirus infecting Arabidopsis thaliana. With an integrated model, it is possible to analyze the mode of virus action and how the perturbation of the virus targets propagates along the network. These studies suggest that viral pathogenicity results not only from the alteration of individual elements but it is a systemic property.

  17. Meson exchange current (MEC) models in neutrino interaction generators

    SciTech Connect

    Katori, Teppei

    2015-05-15

    Understanding of the so-called 2 particle-2 hole (2p-2h) effect is an urgent program in neutrino interaction physics for current and future oscillation experiments. Such processes are believed to be responsible for the event excesses observed by recent neutrino experiments. The 2p-2h effect is dominated by the meson exchange current (MEC), and is accompanied by a 2-nucleon emission from the primary vertex, instead of a single nucleon emission from the charged-current quasi-elastic (CCQE) interaction. Current and future high resolution experiments can potentially nail down this effect. For this reason, there are world wide efforts to model and implement this process in neutrino interaction simulations. In these proceedings, I would like to describe how this channel is modeled in neutrino interaction generators.

  18. General form of the boson-fermion interaction in the interacting boson-fermion model-2

    NASA Astrophysics Data System (ADS)

    Matus, F. A.; Barea, J.

    2017-03-01

    The boson-fermion interaction in the interacting boson-fermion model-2 (IBFM-2) is derived in a systematic and general form from a quadrupole-quadrupole force using several nondegenerate levels. The boson-fermion quadrupole operator employed is obtained from the boson-fermion image of the one nucleon transfer operator which in turn can be calculated following two alternative schemes: the Otsuka-Arima-Iachello and generalized Holstein-Primakoff schemes. Four different terms (two quadrupole and two exchange) were obtained. Application of the new expressions to a single-j model is studied and analyzed.

  19. Effects of Latent Variable Nonnormality and Model Misspecification on Testing Structural Equation Modeling Interactions

    ERIC Educational Resources Information Center

    Sun, Shaojing; Konold, Timothy R.; Fan, Xitao

    2011-01-01

    Interest in testing interaction terms within the latent variable modeling framework has been on the rise in recent years. However, little is known about the influence of nonnormality and model misspecification on such models that involve latent variable interactions. The authors used Mattson's data generation method to control for latent variable…

  20. A Computational Dual-Process Model of Social Interaction

    DTIC Science & Technology

    2014-01-30

    to facilitate the building of the computational models of agents, visualized as avatars , which pursue goals that drive their behaviors in social...employed for over 20 years. OMAR was used to facilitate the building of the computational models in which the agents, visualized as avatars , pursue the...overview of the visualization of the scenarios’ human performance models as avatars that portray the social interactions of the individuals involved. 3

  1. Continuum electromechanical modeling of protein-membrane interactions.

    PubMed

    Zhou, Y C; Lu, Benzhuo; Gorfe, Alemayehu A

    2010-10-01

    A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system. The model couples the macroscopic strain energy of membrane and the electrostatic solvation energy of the system, and equilibrium membrane deformation is obtained by minimizing the electroelastic energy functional with respect to the dielectric interface. The model is illustrated with the systems with increasing geometry complexity and captures the sensitivity of membrane curvature to the permanent and mobile charge distributions.

  2. Multinucleon Ejection Model for Two Body Current Neutrino Interactions

    SciTech Connect

    Sobczyk, Jan T.; /Fermilab

    2012-06-01

    A model is proposed to describe nucleons ejected from a nucleus as a result of two-body-current neutrino interactions. The model can be easily implemented in Monte Carlo neutrino event generators. Various possibilities to measure the two-body-current contribution are discussed. The model can help identify genuine charge current quasielastic events and allow for a better determination of the systematic error on neutrino energy reconstruction in neutrino oscillation experiments.

  3. NON-LINEAR MODELING OF THE RHIC INTERACTION REGIONS.

    SciTech Connect

    TOMAS,R.FISCHER,W.JAIN,A.LUO,Y.PILAT,F.

    2004-07-05

    For RHIC's collision lattices the dominant sources of transverse non-linearities are located in the interaction regions. The field quality is available for most of the magnets in the interaction regions from the magnetic measurements, or from extrapolations of these measurements. We discuss the implementation of these measurements in the MADX models of the Blue and the Yellow rings and their impact on beam stability.

  4. Speech Perception as a Cognitive Process: The Interactive Activation Model.

    DTIC Science & Technology

    1983-04-01

    one another in COHORT, the nodes for sell, your, light, and cellulite , wil all bc in active competition with one another. The system will have no way...7 AD-AI28 787 SPEECH PERCEPTION AS A COGNITIVE PROCESS: THE INTERACTIVE ACTIVATION MODE..(U) CALIFORNIA UNIV SAN D IEGO LA dOLLA INST FOR COGNITIVE...TYPE OF REPORT & PERIOD COVERED Speech Perception as a Cognitive Process: Technical Report The Interactive Activation Model S. PERFORMING ORG. REPORT

  5. Cosmological future singularities in interacting dark energy models

    NASA Astrophysics Data System (ADS)

    Jiménez, Jose Beltrán; Rubiera-Garcia, Diego; Sáez-Gómez, Diego; Salzano, Vincenzo

    2016-12-01

    The existence of interactions between dark matter and dark energy has been widely studied, since they can fit well the observational data and may provide new physics through such an interaction. In this work, we analyze these models and investigate their potential relation with future cosmological singularities. We find that every future singularity found in the literature can be mapped into a singularity of the interaction term, that we call the Q singularity, where the energy flow between the dark components diverges. Furthermore, this framework allows us to identify a new type of future singularity induced by the divergence of the first derivative of the dark energy equation of state parameter.

  6. Towards an interactive electromechanical model of the heart

    PubMed Central

    Talbot, Hugo; Marchesseau, Stéphanie; Duriez, Christian; Sermesant, Maxime; Cotin, Stéphane; Delingette, Hervé

    2013-01-01

    In this work, we develop an interactive framework for rehearsal of and training in cardiac catheter ablation, and for planning cardiac resynchronization therapy. To this end, an interactive and real-time electrophysiology model of the heart is developed to fit patient-specific data. The proposed interactive framework relies on two main contributions. First, an efficient implementation of cardiac electrophysiology is proposed, using the latest graphics processing unit computing techniques. Second, a mechanical simulation is then coupled to the electrophysiological signals to produce realistic motion of the heart. We demonstrate that pathological mechanical and electrophysiological behaviour can be simulated. PMID:24427533

  7. The growth of structure in interacting dark energy models

    SciTech Connect

    Caldera-Cabral, Gabriela; Maartens, Roy; Schaefer, Bjoern Malte E-mail: roy.maartens@port.ac.uk

    2009-07-01

    If dark energy interacts with dark matter, there is a change in the background evolution of the universe, since the dark matter density no longer evolves as a{sup −3}. In addition, the non-gravitational interaction affects the growth of structure. In principle, these changes allow us to detect and constrain an interaction in the dark sector. Here we investigate the growth factor and the weak lensing signal for a new class of interacting dark energy models. In these models, the interaction generalises the simple cases where one dark fluid decays into the other. In order to calculate the effect on structure formation, we perform a careful analysis of the perturbed interaction and its effect on peculiar velocities. Assuming a normalization to today's values of dark matter density and overdensity, the signal of the interaction is an enhancement (suppression) of both the growth factor and the lensing power, when the energy transfer in the background is from dark matter to dark energy (dark energy to dark matter)

  8. Analyzing models for interactions of aptamers to proteins

    NASA Astrophysics Data System (ADS)

    Silva, Dilson; Missailidis, Sotiris

    2014-10-01

    We have devised an experimental and theoretical model, based on fluorescent spectroscopy and molecular modelling, to describe the interaction of aptamer (selected against various protein targets) with proteins and albumins in particular. This model, described in this work, has allowed us to decipher the nature of the interactions between aptamers and albumins, the binding site of the aptamers to albumins, the potential role of primer binding to the albumin and expand to the ability of albumin to carry aptamers in the bloodstream, providing data to better understand the level of free aptamer for target binding. We are presenting the study of a variety of aptamers, including those against the MUC1 tumour marker, heparanase and human kallikrein 6 with bovine and human serum albumins and the effect these interactions may have on the bioavailability of the aptamer for target-specific binding and therapeutic activity.

  9. Interactive computational models of particle dynamics using virtual reality

    SciTech Connect

    Canfield, T.; Diachin, D.; Freitag, L.; Heath, D.; Herzog, J.; Michels, W.

    1996-12-31

    An increasing number of industrial applications rely on computational models to reduce costs in product design, development, and testing cycles. Here, the authors discuss an interactive environment for the visualization, analysis, and modification of computational models used in industrial settings. In particular, they focus on interactively placing massless, massed, and evaporating particulate matter in computational fluid dynamics applications.they discuss the numerical model used to compute the particle pathlines in the fluid flow for display and analysis. They briefly describe the toolkits developed for vector and scalar field visualization, interactive particulate source placement, and a three-dimensional GUI interface. This system is currently used in two industrial applications, and they present the tools in the context of these applications. They summarize the current state of the project and offer directions for future research.

  10. Combining microsimulation and spatial interaction models for retail location analysis

    NASA Astrophysics Data System (ADS)

    Nakaya, Tomoki; Fotheringham, A. Stewart; Hanaoka, Kazumasa; Clarke, Graham; Ballas, Dimitris; Yano, Keiji

    2007-12-01

    Although the disaggregation of consumers is crucial in understanding the fragmented markets that are dominant in many developed countries, it is not always straightforward to carry out such disaggregation within conventional retail modelling frameworks due to the limitations of data. In particular, consumer grouping based on sampled data is not assured to link with the other statistics that are vital in estimating sampling biases and missing variables in the sampling survey. To overcome this difficulty, we propose a useful combination of spatial interaction modelling and microsimulation approaches for the reliable estimation of retail interactions based on a sample survey of consumer behaviour being linked with other areal statistics. We demonstrate this approach by building an operational retail interaction model to estimate expenditure flows from households to retail stores in a local city in Japan, Kusatsu City.

  11. Modeling of MOX Fuel Pellet-Clad Interaction Using ABAQUS

    SciTech Connect

    Ambrosek, Richard G.; Pedersen, Robert C.; Maple, Amanda

    2002-07-01

    Post-irradiation examination (PIE) has indicated an increase in the outer diameter of fuel pins being irradiated in the Advanced Test Reactor (ATR) for the MOX irradiation program. The diameter increase is the largest in the region between fuel pellets. The fuel pellet was modeled using PATRAN and the model was evaluated using ABAQUS, version 6.2. The results from the analysis indicate the non-uniform clad diameter is caused by interaction between the fuel pellet and the clad. The results also demonstrate that the interaction is not uniform over the pellet axial length, with the largest interaction occurring in the region of the pellet-pellet interface. Results were obtained for an axisymmetric model and for a 1/8 pie shaped segment, using the coupled temperature-displacement solution technique. (authors)

  12. Developing an Empirical Model for Jet-Surface Interaction Noise

    NASA Technical Reports Server (NTRS)

    Brown, Clif

    2014-01-01

    The process of developing an empirical model for jet-surface interaction noise is described and the resulting model evaluated. Jet-surface interaction noise is generated when the high-speed engine exhaust from modern tightly integrated or conventional high-bypass ratio engine aircraft strikes or flows over the airframe surfaces. An empirical model based on an existing experimental database is developed for use in preliminary design system level studies where computation speed and range of configurations is valued over absolute accuracy to select the most promising (or eliminate the worst) possible designs. The model developed assumes that the jet-surface interaction noise spectra can be separated from the jet mixing noise and described as a parabolic function with three coefficients: peak amplitude, spectral width, and peak frequency. These coefficients are t to functions of surface length and distance from the jet lipline to form a characteristic spectra which is then adjusted for changes in jet velocity and/or observer angle using scaling laws from published theoretical and experimental work. The resulting model is then evaluated for its ability to reproduce the characteristic spectra and then for reproducing spectra measured at other jet velocities and observer angles; successes and limitations are discussed considering the complexity of the jet-surface interaction noise versus the desire for a model that is simple to implement and quick to execute.

  13. Developing an Empirical Model for Jet-Surface Interaction Noise

    NASA Technical Reports Server (NTRS)

    Brown, Clifford A.

    2014-01-01

    The process of developing an empirical model for jet-surface interaction noise is described and the resulting model evaluated. Jet-surface interaction noise is generated when the high-speed engine exhaust from modern tightly integrated or conventional high-bypass ratio engine aircraft strikes or flows over the airframe surfaces. An empirical model based on an existing experimental database is developed for use in preliminary design system level studies where computation speed and range of configurations is valued over absolute accuracy to select the most promising (or eliminate the worst) possible designs. The model developed assumes that the jet-surface interaction noise spectra can be separated from the jet mixing noise and described as a parabolic function with three coefficients: peak amplitude, spectral width, and peak frequency. These coefficients are fit to functions of surface length and distance from the jet lipline to form a characteristic spectra which is then adjusted for changes in jet velocity and/or observer angle using scaling laws from published theoretical and experimental work. The resulting model is then evaluated for its ability to reproduce the characteristic spectra and then for reproducing spectra measured at other jet velocities and observer angles; successes and limitations are discussed considering the complexity of the jet-surface interaction noise versus the desire for a model that is simple to implement and quick to execute.

  14. Momentum distribution and non-Fermi-liquid behavior in low-doped two-orbital model: Finite-size cluster quantum Monte Carlo approach

    NASA Astrophysics Data System (ADS)

    Kashurnikov, Vladimir A.; Krasavin, Andrey V.; Zhumagulov, Yaroslav V.

    2016-12-01

    The two-dimensional two-orbital Hubbard model is studied with the use of a finite-size cluster world-line quantum Monte Carlo algorithm. This model is widely used for simulation of the band structure of FeAs clusters, which are structure elements of Fe-based high-temperature superconductors. The choice of a special basis set of hypersites allowed us to take into account four-fermion operator terms and to overcome partly the sign problem. Spectral functions and the density of states for various parameters of the model are obtained in the undoped and low-doped regimes. The correlated distortion of the spectral density with the change of doping is observed, and the applicability of the "hard-band" approximation in the doped regime is demonstrated. Profiles of the momentum distribution are obtained for the first Brillouin zone; they have pronounced jump near the Fermi level, which decreases with the growth of the strength of the interaction. The invariance of the Fermi surface with respect to the strength of the interaction is testified. Nesting is found in the case of electron and hole doping. Fermi-liquid parameters of the model are derived. The Z factor grows sharply with the increasing of the level of doping and monotonously decreases with the growth of the strength of the interaction. Moreover, electron-hole doping asymmetry of the Z factor is revealed. The non-Fermi-liquid behavior and the deviation from Luttinger theorem are observed.

  15. A pairwise interaction model for multivariate functional and longitudinal data.

    PubMed

    Chiou, Jeng-Min; Müller, Hans-Georg

    2016-06-01

    Functional data vectors consisting of samples of multivariate data where each component is a random function are encountered increasingly often but have not yet been comprehensively investigated. We introduce a simple pairwise interaction model that leads to an interpretable and straightforward decomposition of multivariate functional data and of their variation into component-specific processes and pairwise interaction processes. The latter quantify the degree of pairwise interactions between the components of the functional data vectors, while the component-specific processes reflect the functional variation of a particular functional vector component that cannot be explained by the other components. Thus the proposed model provides an extension of the usual notion of a covariance or correlation matrix for multivariate vector data to functional data vectors and generates an interpretable functional interaction map. The decomposition provided by the model can also serve as a basis for subsequent analysis, such as study of the network structure of functional data vectors. The decomposition of the total variance into componentwise and interaction contributions can be quantified by an [Formula: see text]-like decomposition. We provide consistency results for the proposed methods and illustrate the model by applying it to sparsely sampled longitudinal data from the Baltimore Longitudinal Study of Aging, examining the relationships between body mass index and blood fats.

  16. Integrated Sachs-Wolfe effect in interacting dark energy models

    SciTech Connect

    Olivares, German; Pavon, Diego; Atrio-Barandela, Fernando

    2008-05-15

    Models with dark energy decaying into dark matter have been proposed in cosmology to solve the coincidence problem. We study the effect of such coupling on the cosmic microwave background temperature anisotropies. The interaction changes the rate of evolution of the metric potentials and the growth rate of matter density perturbations and modifies the integrated Sachs-Wolfe component of cosmic microwave background temperature anisotropies, enhancing the effect. Cross correlation of galaxy catalogs with cosmic microwave background maps provides a model-independent test to constrain the interaction. We particularize our analysis for a specific interacting model and show that galaxy catalogs with median redshifts z{sub m}=0.1-0.9 can rule out models with an interaction parameter strength of c{sup 2}{approx_equal}0.1 better than 99.95% confidence level. Values of c{sup 2}{<=}0.01 are compatible with the data and may account for the possible discrepancy between the fraction of dark energy derived from Wilkinson microwave anisotropy probe 3 yr data and the fraction obtained from the integrated Sachs-Wolfe effect. Measuring the fraction of dark energy by these two methods could provide evidence of an interaction.

  17. Modeling the dynamic interaction of Hebbian and homeostatic plasticity

    PubMed Central

    Toyoizumi, Taro; Kaneko, Megumi; Stryker, Michael P.; Miller, Kenneth D.

    2014-01-01

    Summary Hebbian and homeostatic plasticity together refine neural circuitry, but their interactions are unclear. In most existing models, each form of plasticity directly modifies synaptic strength. Equilibrium is reached when the two are inducing equal and opposite changes. We show that such models cannot reproduce ocular dominance plasticity (ODP) because negative feedback from the slow homeostatic plasticity observed in ODP cannot stabilize the positive feedback of fast Hebbian plasticity. We propose a new model in which synaptic strength is the product of a synapse-specific Hebbian factor and a postsynaptic-cell-specific homeostatic factor, with each factor separately arriving at a stable inactive state. This model captures ODP dynamics and has plausible biophysical substrates. We experimentally confirm model predictions that plasticity is inactive at stable states and that synaptic strength overshoots during recovery from visual deprivation. These results highlight the importance of multiple regulatory pathways for interactions of plasticity mechanisms operating over separate timescales. PMID:25374364

  18. Interacting boson models for N˜Z nuclei

    NASA Astrophysics Data System (ADS)

    Van Isacker, P.

    2011-05-01

    This contribution discusses the use of boson models in the description of N˜Z nuclei. A brief review is given of earlier attempts, initiated by Elliott and co-workers, to extend the interacting boson model of Arima and Iachello by the inclusion of neutron-proton s and d bosons with T = 1 (IBM-3) as well as T = 0 (IBM-4). It is argued that for the N˜Z nuclei that are currently studied experimentally, a different approach is needed which invokes aligned neutron-proton pairs with angular momentum J = 2j and isospin T = 0. This claim is supported by an analysis of shell-model wave functions in terms of pair states. Results of this alternative version of the interacting boson model are compared with shell-model calculations in the 1g9/2 shell.

  19. Modelling of molten fuel/concrete interactions. [PWR; BWR

    SciTech Connect

    Muir, J. F.; Benjamin, A. S.

    1980-01-01

    A computer program modelling the interaction between molten core materials and structural concrete (CORCON) is being developed to provide quantitative estimates of fuel-melt accident consequences suitable for risk assessment of light water reactors. The principal features of CORCON are reviewed. Models developed for the principal interaction phenomena, inter-component heat transfer, concrete erosion, and melt/gas chemical reactions, are described. Alternative models for the controlling phenomenon, heat transfer from the molten pool to the surrounding concrete, are presented. These models, formulated in conjunction with the development of CORCON, are characterized by the presence or absence of either a gas film or viscous layer of molten concrete at the melt/concrete interface. Predictions of heat transfer based on these models compare favorably with available experimental data.

  20. Interacting boson models for N{approx}Z nuclei

    SciTech Connect

    Van Isacker, P.

    2011-05-06

    This contribution discusses the use of boson models in the description of N{approx}Z nuclei. A brief review is given of earlier attempts, initiated by Elliott and co-workers, to extend the interacting boson model of Arima and Iachello by the inclusion of neutron-proton s and d bosons with T = 1 (IBM-3) as well as T = 0 (IBM-4). It is argued that for the N{approx}Z nuclei that are currently studied experimentally, a different approach is needed which invokes aligned neutron-proton pairs with angular momentum J = 2j and isospin T = 0. This claim is supported by an analysis of shell-model wave functions in terms of pair states. Results of this alternative version of the interacting boson model are compared with shell-model calculations in the 1g{sub 9/2} shell.

  1. Modelling the interaction between flooding events and economic growth

    NASA Astrophysics Data System (ADS)

    Grames, J.; Prskawetz, A.; Grass, D.; Blöschl, G.

    2015-06-01

    Socio-hydrology describes the interaction between the socio-economy and water. Recent models analyze the interplay of community risk-coping culture, flooding damage and economic growth (Di Baldassarre et al., 2013; Viglione et al., 2014). These models descriptively explain the feedbacks between socio-economic development and natural disasters like floods. Contrary to these descriptive models, our approach develops an optimization model, where the intertemporal decision of an economic agent interacts with the hydrological system. In order to build this first economic growth model describing the interaction between the consumption and investment decisions of an economic agent and the occurrence of flooding events, we transform an existing descriptive stochastic model into an optimal deterministic model. The intermediate step is to formulate and simulate a descriptive deterministic model. We develop a periodic water function to approximate the former discrete stochastic time series of rainfall events. Due to the non-autonomous exogenous periodic rainfall function the long-term path of consumption and investment will be periodic.

  2. A six-dimensional Jordan model for electroweak interactions

    NASA Astrophysics Data System (ADS)

    Martínez Merino, Aldo; Obregon, Octavio

    2014-03-01

    We present a model for the electroweak interactions based on the commutative but non-associative exceptional Jordan algebra of Hermitian matrices valued on the octonions. By this means, we propose a construction of a gauge theory which take values in this algebra. Following closely the six-dimensional model proposed by D. Fairlie years ago and using a supergroup, we found a natural structure that provides the weak interaction action with some additional terms; we will briefly comment on their possible meaning. Postdoctoral Fellow at Universidad de Guanajuato.

  3. Development of a Comprehensive Magnetohydrodynamic Model of Solar- Terrestrial Interaction

    DTIC Science & Technology

    1988-12-01

    these new submodels as well as those of the core interaction model are discussed in detail in the following section. 6 4 . SUMMARY OF INTERACTION MODEL...Fluid Dynamics, Plasma Dynamics and Lasers Conference. Honolulu, HI. June 8-10, 1987. 4 . Stahara. S. S., G. M. Molvik and J. R. Spreiter. A New ...Belotserkovskii et al.1 4 and assume that (a) km/sec, sonic Mach number Ms.. = 6.0, and ratio of the only important source of new ions is the photoioniza

  4. Modelling low energy electron interactions for biomedical uses of radiation

    NASA Astrophysics Data System (ADS)

    Fuss, M.; Muñoz, A.; Oller, J. C.; Blanco, F.; Limão-Vieira, P.; Huerga, C.; Téllez, M.; Hubin-Fraskin, M. J.; Nixon, K.; Brunger, M.; García, G.

    2009-11-01

    Current radiation based medical applications in the field of radiotherapy, radio-diagnostic and radiation protection require modelling single particle interactions at the molecular level. Due to their relevance in radiation damage to biological systems, special attention should be paid to include the effect of low energy secondary electrons. In this study we present a single track simulation procedure for photons and electrons which is based on reliable experimental and theoretical cross section data and the energy loss distribution functions derived from our experiments. The effect of including secondary electron interactions in this model will be discussed.

  5. A Generalized Multiple Discrete Interaction Approximation for resonant four-wave interactions in wind wave models

    NASA Astrophysics Data System (ADS)

    Tolman, Hendrik L.

    2013-10-01

    For several decades, the Discrete Interaction Approximation (DIA) for nonlinear resonant four-wave interactions has been the engine of third-generation wind-wave models. The present study presents a Generalized Multiple DIA (GMD) which expands upon the DIA by (i) expanding the definition of the representative quadruplet, (ii) formulating the DIA for arbitrary water depths, (iii) providing complimentary deep and shallow water scaling terms and (iv) allowing for multiple representative quadruplets. The GMD is rigorously derived to be an extension of the DIA, and is backward compatible with it. The free parameters of the GMD are optimized holistically, by optimizing full model behavior in the WAVEWATCH III® wave model as reported in a companion paper. Here, a cascade of GMD configurations with increasing complexity, accuracy and cost is presented. First, the performance of these configurations is discussed using idealized test cases used to optimize the GMD. It is shown that in deep water, GMD configurations can be found which remove most of the errors of the DIA. The GMD is also capable of representing four-wave interactions in extremely shallow water, although some remaining spurious behavior makes applications of this part of the GMD less suitable for operational wave models. Finally, several GMD configurations are applied to an idealized hurricane case, showing that results from idealized test cases indeed are representative for real-world applications, and confirming that such GMD configurations are economically feasible in operational wind wave models. Finally, the DIA results in surprisingly large model errors in hurricane conditions.

  6. Critical properties of an aperiodic model for interacting polymers

    NASA Astrophysics Data System (ADS)

    Haddad, T. A. S.; Andrade, R. F. S.; Salinas, S. R.

    2004-02-01

    We investigate the effects of aperiodic interactions on the critical behaviour of an interacting two-polymer model on hierarchical lattices (equivalent to the Migadal-Kadanoff approximation for the model on Bravais lattices), via renormalization-group and transfer-matrix calculations. The exact renormalization-group recursion relations always present a symmetric fixed point, associated with the critical behaviour of the underlying uniform model. If the aperiodic interactions, defined by substitution rules, lead to relevant geometric fluctuations, this fixed point becomes fully unstable, giving rise to novel attractors of different nature. We present an explicit example in which this new attractor is a two-cycle attractor, with critical indices different from the uniform model. In the case of the four-letter Rudin-Shapiro substitution rule, we find a surprising closed curve whose points are attractors of period two, associated with a marginal operator. Nevertheless, a scaling analysis indicates that this attractor may lead to a new critical universality class. In order to provide an independent confirmation of the scaling results, we turn to a direct thermodynamic calculation of the specific-heat exponent. The thermodynamic free energy is obtained from a transfer-matrix formalism, which had been previously introduced for spin systems, and is now extended to the two-polymer model with aperiodic interactions.

  7. Interactive Reliability Model for Whisker-toughened Ceramics

    NASA Technical Reports Server (NTRS)

    Palko, Joseph L.

    1993-01-01

    Wider use of ceramic matrix composites (CMC) will require the development of advanced structural analysis technologies. The use of an interactive model to predict the time-independent reliability of a component subjected to multiaxial loads is discussed. The deterministic, three-parameter Willam-Warnke failure criterion serves as the theoretical basis for the reliability model. The strength parameters defining the model are assumed to be random variables, thereby transforming the deterministic failure criterion into a probabilistic criterion. The ability of the model to account for multiaxial stress states with the same unified theory is an improvement over existing models. The new model was coupled with a public-domain finite element program through an integrated design program. This allows a design engineer to predict the probability of failure of a component. A simple structural problem is analyzed using the new model, and the results are compared to existing models.

  8. Interactive models for semantic labeling of satellite images

    NASA Astrophysics Data System (ADS)

    Koperski, Krzysztof; Marchisio, Giovanni B.; Tusk, Carsten; Aksoy, Selim

    2002-09-01

    We describe a system for interactive training of models for semantic labeling of land cover. The models are build based on three levels of features: 1) pixel level, 2) region level, and 3) scene level features. We developed a Bayesian algorithm and a decision tree algorithm for interactive training. The Bayesian algorithm enables training based on pixel features. The scene level summaries of pixel features are used for fast retrieval of scenes with high/low content of features and scenes with low confidence of classification. The decision tree algorithm is based on region level features that are extracted based on 1) spectral and textural characteristics of the image, 2) shape descriptors of regions that are created through segmentation process, and 3) auxiliary information such as elevation data. The initial model can be created based on a database of ground truth and than be refined based on the feedback supplied by a data analyst who interactively trains the model using the system output and/or additional scenes. The combination of supervised and unsupervised methods provides a more complete exploration of model space. A user may detect the inadequacy of the model space and add additional features to the model. The graphical tools for the exploration of decision trees allow insight into the interaction of features used in the construction of models. The preliminary experiments show that accurate models can be build in a short time for a variety of land covers. The scalable classification techniques allow for fast searches for a specific label over a large area.

  9. Spoken language interaction with model uncertainty: an adaptive human-robot interaction system

    NASA Astrophysics Data System (ADS)

    Doshi, Finale; Roy, Nicholas

    2008-12-01

    Spoken language is one of the most intuitive forms of interaction between humans and agents. Unfortunately, agents that interact with people using natural language often experience communication errors and do not correctly understand the user's intentions. Recent systems have successfully used probabilistic models of speech, language and user behaviour to generate robust dialogue performance in the presence of noisy speech recognition and ambiguous language choices, but decisions made using these probabilistic models are still prone to errors owing to the complexity of acquiring and maintaining a complete model of human language and behaviour. In this paper, a decision-theoretic model for human-robot interaction using natural language is described. The algorithm is based on the Partially Observable Markov Decision Process (POMDP), which allows agents to choose actions that are robust not only to uncertainty from noisy or ambiguous speech recognition but also unknown user models. Like most dialogue systems, a POMDP is defined by a large number of parameters that may be difficult to specify a priori from domain knowledge, and learning these parameters from the user may require an unacceptably long training period. An extension to the POMDP model is described that allows the agent to acquire a linguistic model of the user online, including new vocabulary and word choice preferences. The approach not only avoids a training period of constant questioning as the agent learns, but also allows the agent actively to query for additional information when its uncertainty suggests a high risk of mistakes. The approach is demonstrated both in simulation and on a natural language interaction system for a robotic wheelchair application.

  10. Stochastic hyperfine interactions modeling library-Version 2

    NASA Astrophysics Data System (ADS)

    Zacate, Matthew O.; Evenson, William E.

    2016-02-01

    The stochastic hyperfine interactions modeling library (SHIML) provides a set of routines to assist in the development and application of stochastic models of hyperfine interactions. The library provides routines written in the C programming language that (1) read a text description of a model for fluctuating hyperfine fields, (2) set up the Blume matrix, upon which the evolution operator of the system depends, and (3) find the eigenvalues and eigenvectors of the Blume matrix so that theoretical spectra of experimental techniques that measure hyperfine interactions can be calculated. The optimized vector and matrix operations of the BLAS and LAPACK libraries are utilized. The original version of SHIML constructed and solved Blume matrices for methods that measure hyperfine interactions of nuclear probes in a single spin state. Version 2 provides additional support for methods that measure interactions on two different spin states such as Mössbauer spectroscopy and nuclear resonant scattering of synchrotron radiation. Example codes are provided to illustrate the use of SHIML to (1) generate perturbed angular correlation spectra for the special case of polycrystalline samples when anisotropy terms of higher order than A22 can be neglected and (2) generate Mössbauer spectra for polycrystalline samples for pure dipole or pure quadrupole transitions.

  11. 19 Gene × Environment Interaction Models in Psychiatric Genetics

    PubMed Central

    Karg, Katja; Sen, Srijan

    2013-01-01

    Gene-environment (G×E) interaction research is an emerging area in psychiatry, with the number of G×E studies growing rapidly in the past two decades. This article aims to give a comprehensive introduction to the field, with an emphasis on central theoretical and practical problems that are worth considering before conducting a G×E interaction study. On the theoretical side, we discuss two fundamental, but controversial questions about (1) the validity of statistical models for biological interaction and (2) the utility of G×E research for psychiatric genetics. On the practical side, we focus on study characteristics that potentially influence the outcome of G×E interaction studies and discuss strengths and pitfalls of different study designs, including recent approaches like Genome-Environment Wide Interaction Studies (GEWIS). Finally, we discuss recent developments in G×E interaction research on the most heavily investigated example in psychiatric genetics, the interaction between a serotonin transporter gene promoter variant (5-HTTLPR) and stress on depression. PMID:22241248

  12. Sensitivity analysis of random shell-model interactions

    NASA Astrophysics Data System (ADS)

    Krastev, Plamen; Johnson, Calvin

    2010-02-01

    The input to the configuration-interaction shell model includes many dozens or even hundreds of independent two-body matrix elements. Previous studies have shown that when fitting to experimental low-lying spectra, the greatest sensitivity is to only a few linear combinations of matrix elements. Following Brown and Richter [1], here we consider general two-body interactions in the 1s-0d shell and find that the low-lying spectra are also only sensitive to a few linear combinations of two-body matrix elements. We find out in particular the ground state energies for both the random and non-random (here given by the USDB) interaction are dominated by similar matrix elements, which we try to interpret in terms of monopole and contact interactions, while the excitation energies have completely different character. [4pt] [1] B. Alex Brown and W. A. Richter, Phys. Rev. C 74, 034315 (2006) )

  13. Interactive Rapid Dose Assessment Model (IRDAM): user's guide

    SciTech Connect

    Poeton, R.W.; Moeller, M.P.; Laughlin, G.J.; Desrosiers, A.E.

    1983-05-01

    As part of the continuing emphasis on emergency preparedness the US Nuclear Regulatory Commission (NRC) sponsored the development of a rapid dose assessment system by Pacific Northwest Laboratory (PNL). This system, the Interactive Rapid Dose Assessment Model (IRDAM) is a micro-computer based program for rapidly assessing the radiological impact of accidents at nuclear power plants. This User's Guide provides instruction in the setup and operation of the equipment necessary to run IRDAM. Instructions are also given on how to load the magnetic disks and access the interactive part of the program. Two other companion volumes to this one provide additional information on IRDAM. Reactor Accident Assessment Methods (NUREG/CR-3012, Volume 2) describes the technical bases for IRDAM including methods, models and assumptions used in calculations. Scenarios for Comparing Dose Assessment Models (NUREG/CR-3012, Volume 3) provides the results of calculations made by IRDAM and other models for specific accident scenarios.

  14. Information on biotic interactions improves transferability of distribution models.

    PubMed

    Godsoe, William; Murray, Rua; Plank, Michael J

    2015-02-01

    Predicting changes in species' distributions is a crucial problem in ecology, with leading methods relying on information about species' putative climatic requirements. Empirical support for this approach relies on our ability to use observations of a species' distribution in one region to predict its range in other regions (model transferability). On the basis of this observation, ecologists have hypothesized that climate is the strongest determinant of species' distributions at large spatial scales. However, it is difficult to reconcile this claim with the pervasive effects of biotic interactions. Here, we resolve this apparent paradox by demonstrating how biotic interactions can affect species' range margins yet still be compatible with model transferability. We also identify situations where small changes in species' interactions dramatically shift range margins.

  15. Enhanced compressibility due to repulsive interaction in the Harper model

    NASA Astrophysics Data System (ADS)

    Kraus, Yaacov E.; Zilberberg, Oded; Berkovits, Richard

    2014-04-01

    We study the interplay between a repulsive interaction and an almost staggered on-site potential in one dimension. Specifically, we address the Harper model for spinless fermions with nearest-neighbor repulsion, close to half filling. Using the density matrix renormalization group, we find that, in contrast to standard behavior, the system becomes more compressible as the repulsive interaction is increased. By deriving a low-energy effective model, we unveil the effect of interactions using mean-field analysis: The density of a narrow band around half filling is anticorrelated with the on-site potential, whereas the density of lower occupied bands follows the potential and strengthens it. As a result, the states around half filling are squeezed by the background density, their band becomes flatter, and the compressibility increases.

  16. Tools and Equipment Modeling for Automobile Interactive Assembling Operating Simulation

    SciTech Connect

    Wu Dianliang; Zhu Hongmin

    2010-05-21

    Tools and equipment play an important role in the simulation of virtual assembly, especially in the assembly process simulation and plan. Because of variety in function and complexity in structure and manipulation, the simulation of tools and equipments remains to be a challenge for interactive assembly operation. Based on analysis of details and characteristics of interactive operations for automobile assembly, the functional requirement for tools and equipments of automobile assembly is given. Then, a unified modeling method for information expression and function realization of general tools and equipments is represented, and the handling methods of manual, semi-automatic, automatic tools and equipments are discussed. Finally, the application in assembly simulation of rear suspension and front suspension of Roewe 750 automobile is given. The result shows that the modeling and handling methods are applicable in the interactive simulation of various tools and equipments, and can also be used for supporting assembly process planning in virtual environment.

  17. Making Transporter Models for Drug-Drug Interaction Prediction Mobile.

    PubMed

    Ekins, Sean; Clark, Alex M; Wright, Stephen H

    2015-10-01

    The past decade has seen increased numbers of studies publishing ligand-based computational models for drug transporters. Although they generally use small experimental data sets, these models can provide insights into structure-activity relationships for the transporter. In addition, such models have helped to identify new compounds as substrates or inhibitors of transporters of interest. We recently proposed that many transporters are promiscuous and may require profiling of new chemical entities against multiple substrates for a specific transporter. Furthermore, it should be noted that virtually all of the published ligand-based transporter models are only accessible to those involved in creating them and, consequently, are rarely shared effectively. One way to surmount this is to make models shareable or more accessible. The development of mobile apps that can access such models is highlighted here. These apps can be used to predict ligand interactions with transporters using Bayesian algorithms. We used recently published transporter data sets (MATE1, MATE2K, OCT2, OCTN2, ASBT, and NTCP) to build preliminary models in a commercial tool and in open software that can deliver the model in a mobile app. In addition, several transporter data sets extracted from the ChEMBL database were used to illustrate how such public data and models can be shared. Predicting drug-drug interactions for various transporters using computational models is potentially within reach of anyone with an iPhone or iPad. Such tools could help prioritize which substrates should be used for in vivo drug-drug interaction testing and enable open sharing of models.

  18. Finite Element Modeling of Tire-Terrain Interaction

    DTIC Science & Technology

    2001-11-01

    cent advancements in the contact formulations of general-purpose finite element codes (e.g. ABAQUS , HKS 1998) and increases in computer processing...are based on the models as implemented in ABAQUS (HKS 1998). Additional information on soil plasticity and critical state soil mechanics is given...snow interaction, however, the model must simulate snow deformation in a three-dimensional stress field. Initial simulations using the ABAQUS

  19. Modeling of nonlinear interactions between guided waves and fatigue cracks using local interaction simulation approach.

    PubMed

    Shen, Yanfeng; Cesnik, Carlos E S

    2017-02-01

    This article presents a parallel algorithm to model the nonlinear dynamic interactions between ultrasonic guided waves and fatigue cracks. The Local Interaction Simulation Approach (LISA) is further developed to capture the contact-impact clapping phenomena during the wave crack interactions based on the penalty method. Initial opening and closure distributions are considered to approximate the 3-D rough crack microscopic features. A Coulomb friction model is integrated to capture the stick-slip contact motions between the crack surfaces. The LISA procedure is parallelized via the Compute Unified Device Architecture (CUDA), which enables parallel computing on powerful graphic cards. The explicit contact formulation, the parallel algorithm, as well as the GPU-based implementation facilitate LISA's high computational efficiency over the conventional finite element method (FEM). This article starts with the theoretical formulation and numerical implementation of the proposed algorithm, followed by the solution behavior study and numerical verification against a commercial finite element code. Numerical case studies are conducted on Lamb wave interactions with fatigue cracks. Several nonlinear ultrasonic phenomena are addressed. The classical nonlinear higher harmonic and DC response are successfully captured. The nonlinear mode conversion at a through-thickness and a half-thickness fatigue crack is investigated. Threshold behaviors, induced by initial openings and closures of rough crack surfaces, are depicted by the proposed contact LISA model.

  20. Modeling seasonal interactions in the population dynamics of migratory birds

    USGS Publications Warehouse

    Runge, M.C.; Marra, P.P.; Greenberg, Russell; Marra, Peter P.

    2005-01-01

    Understanding the population dynamics of migratory birds requires understanding the relevant biological events that occur during breeding, migratory, and overwintering periods. The few available population models for passerine birds focus on breeding-season events, disregard or oversimplify events during nonbreeding periods, and ignore interactions that occur between periods of the annual cycle. Identifying and explicitly incorporating seasonal interactions into population models for migratory birds could provide important insights about when population limitation actually occurs in the annual cycle. We present a population model for the annual cycle of a migratory bird, based on the American Redstart (Setophaga ruticilla) but more generally applicable, that examines the importance of seasonal interactions by incorporating: (1) density dependence during the breeding and winter seasons, (2) a carry-over effect of winter habitat on breeding-season productivity, and (3) the effects of behavioral dominance on seasonal and habitat specific demographic rates. First, we show that habitat availability on both the wintering and breeding grounds can strongly affect equilibrium population size and sex ratio. Second, sex ratio dynamics, as mediated by behavioral dominance, can affect all other aspects of population dynamics. Third, carry-over effects can be strong, especially when winter events are limiting. These results suggest that understanding the population dynamics of migratory birds may require more consideration of the seasonal interactions induced by carry-over effects and density dependence in multiple seasons. This model provides a framework in which to explore more fully these seasonal dynamics and a context for estimation of life history parameters.

  1. Bilingual Parents' Modeling of Pragmatic Language Use in Multiparty Interactions

    ERIC Educational Resources Information Center

    Tare, Medha; Gelman, Susan A.

    2011-01-01

    Parental input represents an important source of language socialization. Particularly in bilingual contexts, parents may model pragmatic language use and metalinguistic strategies to highlight language differences. The present study examines multiparty interactions involving 28 bilingual English- and Marathi-speaking parent-child pairs in the…

  2. Geometry of coexistence in the interacting boson model

    SciTech Connect

    Van Isacker, P.; Frank, A.; Vargas, C.E.

    2004-09-13

    The Interacting Boson Model (IBM) with configuration mixing is applied to describe the phenomenon of coexistence in nuclei. The analysis suggests that the IBM with configuration mixing, used in conjunction with a (matrix) coherent-state method, may be a reliable tool for the study of geometric aspects of shape coexistence in nuclei.

  3. Multi-particle interaction in a model of the hydrophobic interaction

    NASA Astrophysics Data System (ADS)

    Bedeaux, D.; Koper, G. J. M.; Ispolatov, S.; Widom, B.

    2001-03-01

    The multi-particle potential of mean force between interstitial solute molecules in Ben-Naim's one-dimensional, many-state lattice model is calculated. The solution is a direct extension of an earlier calculation of the two-particle interaction by Kolomeisky and Widom (Faraday Dis. 112 (1999) 81). It is found that the many-particle interaction potential is a sum of pair potentials between neighboring particles only. An exact equation of state, expressing the activity in the temperature and the pressure, is derived. The resulting solubility of a gaseous hydrophobe, which is defined osmotically, is calculated and found to increase considerably with the gas density.

  4. A coarse grain model for protein-surface interactions.

    PubMed

    Wei, Shuai; Knotts, Thomas A

    2013-09-07

    The interaction of proteins with surfaces is important in numerous applications in many fields-such as biotechnology, proteomics, sensors, and medicine--but fundamental understanding of how protein stability and structure are affected by surfaces remains incomplete. Over the last several years, molecular simulation using coarse grain models has yielded significant insights, but the formalisms used to represent the surface interactions have been rudimentary. We present a new model for protein surface interactions that incorporates the chemical specificity of both the surface and the residues comprising the protein in the context of a one-bead-per-residue, coarse grain approach that maintains computational efficiency. The model is parameterized against experimental adsorption energies for multiple model peptides on different types of surfaces. The validity of the model is established by its ability to quantitatively and qualitatively predict the free energy of adsorption and structural changes for multiple biologically-relevant proteins on different surfaces. The validation, done with proteins not used in parameterization, shows that the model produces remarkable agreement between simulation and experiment.

  5. Modeling attacker-defender interactions in information networks.

    SciTech Connect

    Collins, Michael Joseph

    2010-09-01

    The simplest conceptual model of cybersecurity implicitly views attackers and defenders as acting in isolation from one another: an attacker seeks to penetrate or disrupt a system that has been protected to a given level, while a defender attempts to thwart particular attacks. Such a model also views all non-malicious parties as having the same goal of preventing all attacks. But in fact, attackers and defenders are interacting parts of the same system, and different defenders have their own individual interests: defenders may be willing to accept some risk of successful attack if the cost of defense is too high. We have used game theory to develop models of how non-cooperative but non-malicious players in a network interact when there is a substantial cost associated with effective defensive measures. Although game theory has been applied in this area before, we have introduced some novel aspects of player behavior in our work, including: (1) A model of how players attempt to avoid the costs of defense and force others to assume these costs; (2) A model of how players interact when the cost of defending one node can be shared by other nodes; and (3) A model of the incentives for a defender to choose less expensive, but less effective, defensive actions.

  6. A coarse grain model for protein-surface interactions

    NASA Astrophysics Data System (ADS)

    Wei, Shuai; Knotts, Thomas A.

    2013-09-01

    The interaction of proteins with surfaces is important in numerous applications in many fields—such as biotechnology, proteomics, sensors, and medicine—but fundamental understanding of how protein stability and structure are affected by surfaces remains incomplete. Over the last several years, molecular simulation using coarse grain models has yielded significant insights, but the formalisms used to represent the surface interactions have been rudimentary. We present a new model for protein surface interactions that incorporates the chemical specificity of both the surface and the residues comprising the protein in the context of a one-bead-per-residue, coarse grain approach that maintains computational efficiency. The model is parameterized against experimental adsorption energies for multiple model peptides on different types of surfaces. The validity of the model is established by its ability to quantitatively and qualitatively predict the free energy of adsorption and structural changes for multiple biologically-relevant proteins on different surfaces. The validation, done with proteins not used in parameterization, shows that the model produces remarkable agreement between simulation and experiment.

  7. Interactive graphical model building using telepresence and virtual reality

    SciTech Connect

    Cooke, C.; Stansfield, S.

    1993-10-01

    This paper presents a prototype system developed at Sandia National Laboratories to create and verify computer-generated graphical models of remote physical environments. The goal of the system is to create an interface between an operator and a computer vision system so that graphical models can be created interactively. Virtual reality and telepresence are used to allow interaction between the operator, computer, and remote environment. A stereo view of the remote environment is produced by two CCD cameras. The cameras are mounted on a three degree-of-freedom platform which is slaved to a mechanically-tracked, stereoscopic viewing device. This gives the operator a sense of immersion in the physical environment. The stereo video is enhanced by overlaying the graphical model onto it. Overlay of the graphical model onto the stereo video allows visual verification of graphical models. Creation of a graphical model is accomplished by allowing the operator to assist the computer in modeling. The operator controls a 3-D cursor to mark objects to be modeled. The computer then automatically extracts positional and geometric information about the object and creates the graphical model.

  8. The effect of model uncertainty on cooperation in sensorimotor interactions

    PubMed Central

    Grau-Moya, J.; Hez, E.; Pezzulo, G.; Braun, D. A.

    2013-01-01

    Decision-makers have been shown to rely on probabilistic models for perception and action. However, these models can be incorrect or partially wrong in which case the decision-maker has to cope with model uncertainty. Model uncertainty has recently also been shown to be an important determinant of sensorimotor behaviour in humans that can lead to risk-sensitive deviations from Bayes optimal behaviour towards worst-case or best-case outcomes. Here, we investigate the effect of model uncertainty on cooperation in sensorimotor interactions similar to the stag-hunt game, where players develop models about the other player and decide between a pay-off-dominant cooperative solution and a risk-dominant, non-cooperative solution. In simulations, we show that players who allow for optimistic deviations from their opponent model are much more likely to converge to cooperative outcomes. We also implemented this agent model in a virtual reality environment, and let human subjects play against a virtual player. In this game, subjects' pay-offs were experienced as forces opposing their movements. During the experiment, we manipulated the risk sensitivity of the computer player and observed human responses. We found not only that humans adaptively changed their level of cooperation depending on the risk sensitivity of the computer player but also that their initial play exhibited characteristic risk-sensitive biases. Our results suggest that model uncertainty is an important determinant of cooperation in two-player sensorimotor interactions. PMID:23945266

  9. Dark Matter in the Heavens and at Colliders: Models and Constraints

    SciTech Connect

    Primulando, Reinard

    2012-08-01

    In this dissertation, we investigate various aspects of dark matter detection and model building. Motivated by the cosmic ray positron excess observed by PAMELA, we construct models of decaying dark matter to explain the excess. Specifically we present an explicit, TeV-scale model of decaying dark matter in which the approximate stability of the dark matter candidate is a consequence of a global symmetry that is broken only by instanton-induced operators generated by a non-Abelian dark gauge group. Alternatively, the decaying operator can arise as a Planck suppressed correction in a model with an Abelian discrete symmetry and vector-like states at an intermediate scale that are responsible for generating lepton Yukawa couplings. A flavor-nonconserving dark matter decay is also considered in the case of fermionic dark matter. Assuming a general Dirac structure for the four-fermion contact interactions of interest, the cosmic-ray electron and positron spectra were studied. We show that good fits to the current data can be obtained for both charged-leptonflavor- conserving and flavor-violating decay channels. Motivated by a possible excess of gamma rays in the galactic center, we constructed a supersymmetric leptophilic higgs model to explain the excess. Finally, we consider an improvement on dark matter collider searches using the Razor analysis, which was originally utilized for supersymmetry searches by the CMS collaboration.

  10. Factor selection and structural identification in the interaction ANOVA model.

    PubMed

    Post, Justin B; Bondell, Howard D

    2013-03-01

    When faced with categorical predictors and a continuous response, the objective of an analysis often consists of two tasks: finding which factors are important and determining which levels of the factors differ significantly from one another. Often times, these tasks are done separately using Analysis of Variance (ANOVA) followed by a post hoc hypothesis testing procedure such as Tukey's Honestly Significant Difference test. When interactions between factors are included in the model the collapsing of levels of a factor becomes a more difficult problem. When testing for differences between two levels of a factor, claiming no difference would refer not only to equality of main effects, but also to equality of each interaction involving those levels. This structure between the main effects and interactions in a model is similar to the idea of heredity used in regression models. This article introduces a new method for accomplishing both of the common analysis tasks simultaneously in an interaction model while also adhering to the heredity-type constraint on the model. An appropriate penalization is constructed that encourages levels of factors to collapse and entire factors to be set to zero. It is shown that the procedure has the oracle property implying that asymptotically it performs as well as if the exact structure were known beforehand. We also discuss the application to estimating interactions in the unreplicated case. Simulation studies show the procedure outperforms post hoc hypothesis testing procedures as well as similar methods that do not include a structural constraint. The method is also illustrated using a real data example.

  11. The Soliton-Soliton Interaction in the Chiral Dilaton Model

    NASA Astrophysics Data System (ADS)

    Mantovani-Sarti, Valentina; Park, Byung-Yoon; Vento, Vicente

    2013-10-01

    We study the interaction between two B = 1 states in the Chiral Dilaton Model where baryons are described as nontopological solitons arising from the interaction of chiral mesons and quarks. By using the hedgehog solution for B = 1 states we construct, via a product ansatz, three possible B = 2 configurations to analyse the role of the relative orientation of the hedgehog quills in the dynamics of the soliton-soliton interaction and investigate the behavior of these solutions in the range of long/intermediate distance. One of the solutions is quite binding due to the dynamics of the π and σ fields at intermediate distance and should be used for nuclear matter studies. Since the product ansatz break down as the two solitons get close, we explore the short range distance regime with a model that describes the interaction via a six-quark bag ansatz. We calculate the interaction energy as a function of the inter-soliton distance and show that for small separations the six quarks bag, assuming a hedgehog structure, provides a stable bound state that at large separations connects with a special configuration coming from the product ansatz.

  12. Compressibility enhancement in an almost staggered interacting Harper model

    NASA Astrophysics Data System (ADS)

    Friedman, Bat-el; Berkovits, Richard

    2015-03-01

    We discuss the compressibility in the almost staggered fermionic Harper model with repulsive interactions in the vicinity of half-filling. It has been shown by Kraus et al. [Phys. Rev. B 89, 161106(R) (2014)], 10.1103/PhysRevB.89.161106 that for spinless electrons and nearest neighbors electron-electron interactions the compressibility in the central band is enhanced by repulsive interactions. Here we would like to investigate the sensitivity of this conclusion to the spin degree of freedom and longer range interactions. We use the Hartree-Fock (HF) approximation, as well as the density matrix renormalization group (DMRG) calculation to evaluate the compressibility. In the almost staggered Harper model, the central energy band is essentially flat and separated from the other bands by a large gap and therefore, the HF approximation is rather accurate. In both cases the compressibility of the system is enhanced compared to the noninteracting case, although the enhancement is weaker due to the inclusion of Hubbard and longer ranged interactions. We also show that the entanglement entropy is suppressed when the compressibility of the system is enhanced.

  13. Incorporating groundwater-surface water interaction into river management models.

    PubMed

    Valerio, Allison; Rajaram, Harihar; Zagona, Edith

    2010-01-01

    Accurate representation of groundwater-surface water interactions is critical to modeling low river flows in the semi-arid southwestern United States. Although a number of groundwater-surface water models exist, they are seldom integrated with river operation/management models. A link between the object-oriented river and reservoir operations model, RiverWare, and the groundwater model, MODFLOW, was developed to incorporate groundwater-surface water interaction processes, such as river seepage/gains, riparian evapotranspiration, and irrigation return flows, into a rule-based water allocations model. An explicit approach is used in which the two models run in tandem, exchanging data once in each computational time step. Because the MODFLOW grid is typically at a finer resolution than RiverWare objects, the linked model employs spatial interpolation and summation for compatible communication of exchanged variables. The performance of the linked model is illustrated through two applications in the Middle Rio Grande Basin in New Mexico where overappropriation impacts endangered species habitats. In one application, the linked model results are compared with historical data; the other illustrates use of the linked model for determining management strategies needed to attain an in-stream flow target. The flows predicted by the linked model at gauge locations are reasonably accurate except during a few very low flow periods when discrepancies may be attributable to stream gaging uncertainties or inaccurate documentation of diversions. The linked model accounted for complex diversions, releases, groundwater pumpage, irrigation return flows, and seepage between the groundwater system and canals/drains to achieve a schedule of releases that satisfied the in-stream target flow.

  14. Development of a coupled wave-flow-vegetation interaction model

    USGS Publications Warehouse

    Beudin, Alexis; Kalra, Tarandeep; Ganju, Neil Kamal; Warner, John C.

    2017-01-01

    Emergent and submerged vegetation can significantly affect coastal hydrodynamics. However, most deterministic numerical models do not take into account their influence on currents, waves, and turbulence. In this paper, we describe the implementation of a wave-flow-vegetation module into a Coupled-Ocean-Atmosphere-Wave-Sediment Transport (COAWST) modeling system that includes a flow model (ROMS) and a wave model (SWAN), and illustrate various interacting processes using an idealized shallow basin application. The flow model has been modified to include plant posture-dependent three-dimensional drag, in-canopy wave-induced streaming, and production of turbulent kinetic energy and enstrophy to parameterize vertical mixing. The coupling framework has been updated to exchange vegetation-related variables between the flow model and the wave model to account for wave energy dissipation due to vegetation. This study i) demonstrates the validity of the plant posture-dependent drag parameterization against field measurements, ii) shows that the model is capable of reproducing the mean and turbulent flow field in the presence of vegetation as compared to various laboratory experiments, iii) provides insight into the flow-vegetation interaction through an analysis of the terms in the momentum balance, iv) describes the influence of a submerged vegetation patch on tidal currents and waves separately and combined, and v) proposes future directions for research and development.

  15. Development of a coupled wave-flow-vegetation interaction model

    NASA Astrophysics Data System (ADS)

    Beudin, Alexis; Kalra, Tarandeep S.; Ganju, Neil K.; Warner, John C.

    2017-03-01

    Emergent and submerged vegetation can significantly affect coastal hydrodynamics. However, most deterministic numerical models do not take into account their influence on currents, waves, and turbulence. In this paper, we describe the implementation of a wave-flow-vegetation module into a Coupled-Ocean-Atmosphere-Wave-Sediment Transport (COAWST) modeling system that includes a flow model (ROMS) and a wave model (SWAN), and illustrate various interacting processes using an idealized shallow basin application. The flow model has been modified to include plant posture-dependent three-dimensional drag, in-canopy wave-induced streaming, and production of turbulent kinetic energy and enstrophy to parameterize vertical mixing. The coupling framework has been updated to exchange vegetation-related variables between the flow model and the wave model to account for wave energy dissipation due to vegetation. This study i) demonstrates the validity of the plant posture-dependent drag parameterization against field measurements, ii) shows that the model is capable of reproducing the mean and turbulent flow field in the presence of vegetation as compared to various laboratory experiments, iii) provides insight into the flow-vegetation interaction through an analysis of the terms in the momentum balance, iv) describes the influence of a submerged vegetation patch on tidal currents and waves separately and combined, and v) proposes future directions for research and development.

  16. Monotonic single-index models to assess drug interactions.

    PubMed

    Wan, Yubing; Datta, Susmita; Lee, J Jack; Kong, Maiying

    2017-02-20

    Although single-index models have been extensively studied, the monotonicity of the link function f in the single-index model is rarely studied. In many situations, it is desirable that f is monotonic, which results in a monotonic single-index model that can be very useful in economics and biometrics. In this article, we propose a monotonic single-index model in which the link function is constructed using penalized I-splines along with constraints on coefficients to achieve monotonicity of the link function f. An algorithm to estimate the single-index parameters and the link function is developed, and the sandwich estimate of the variance of the index parameters is provided. We propose to apply this monotonic single-index model to estimate the dose-response surface and assess drug interactions while considering the variability of the observed data. An extensive simulation study was carried out to evaluate the performance of the proposed monotonic single-index model. A case study is provided to illustrate the application of the proposed model to estimate the dose-response surface and assess drug interactions. Both the simulation and case study show that the proposed monotonic single-index model works very well. Copyright © 2016 John Wiley & Sons, Ltd.

  17. Vector Interaction Enhanced Bag Model for Astrophysical Applications

    NASA Astrophysics Data System (ADS)

    Klähn, Thomas; Fischer, Tobias

    2015-09-01

    For quark matter studies in astrophysics the thermodynamic bag model (tdBAG) has been widely used. Despite its success it fails to account for various phenomena expected from QCD. We suggest a straightforward extension of tdBAG in order to take the dynamical breaking of chiral symmetry and the influence of vector interactions explicitly into account. As for tdBAG the model mimics confinement in a phenomenological approach. It is based on an analysis of the Nambu-Jona-Lasinio (NJL) model at finite density. Furthermore, we demonstrate how NJL and bag models in this regime follow from the more general and QCD-based framework of the Dyson-Schwinger equations in a medium by assuming simple gluon contact interaction. Based on our simple and novel model, we construct quark hadron hybrid equations of state and systematically study chiral and deconfinement phase transitions, the appearance of s-quarks, and the role of vector interaction. We further study these aspects for matter in β-equilibrium at zero temperature, with particular focus on the current ˜2 {M}⊙ maximum mass constraint for neutron stars. Our approach indicates that the currently only theoretical evidence for the hypothesis of stable strange matter is an artifact of tdBAG and results from neglecting the dynamical breaking of chiral symmetry.

  18. Head Motion Modeling for Human Behavior Analysis in Dyadic Interaction

    PubMed Central

    Xiao, Bo; Georgiou, Panayiotis; Baucom, Brian; Narayanan, Shrikanth S.

    2015-01-01

    This paper presents a computational study of head motion in human interaction, notably of its role in conveying interlocutors’ behavioral characteristics. Head motion is physically complex and carries rich information; current modeling approaches based on visual signals, however, are still limited in their ability to adequately capture these important properties. Guided by the methodology of kinesics, we propose a data driven approach to identify typical head motion patterns. The approach follows the steps of first segmenting motion events, then parametrically representing the motion by linear predictive features, and finally generalizing the motion types using Gaussian mixture models. The proposed approach is experimentally validated using video recordings of communication sessions from real couples involved in a couples therapy study. In particular we use the head motion model to classify binarized expert judgments of the interactants’ specific behavioral characteristics where entrainment in head motion is hypothesized to play a role: Acceptance, Blame, Positive, and Negative behavior. We achieve accuracies in the range of 60% to 70% for the various experimental settings and conditions. In addition, we describe a measure of motion similarity between the interaction partners based on the proposed model. We show that the relative change of head motion similarity during the interaction significantly correlates with the expert judgments of the interactants’ behavioral characteristics. These findings demonstrate the effectiveness of the proposed head motion model, and underscore the promise of analyzing human behavioral characteristics through signal processing methods. PMID:26557047

  19. Evaluating differential effects using regression interactions and regression mixture models

    PubMed Central

    Van Horn, M. Lee; Jaki, Thomas; Masyn, Katherine; Howe, George; Feaster, Daniel J.; Lamont, Andrea E.; George, Melissa R. W.; Kim, Minjung

    2015-01-01

    Research increasingly emphasizes understanding differential effects. This paper focuses on understanding regression mixture models, a relatively new statistical methods for assessing differential effects by comparing results to using an interactive term in linear regression. The research questions which each model answers, their formulation, and their assumptions are compared using Monte Carlo simulations and real data analysis. The capabilities of regression mixture models are described and specific issues to be addressed when conducting regression mixtures are proposed. The paper aims to clarify the role that regression mixtures can take in the estimation of differential effects and increase awareness of the benefits and potential pitfalls of this approach. Regression mixture models are shown to be a potentially effective exploratory method for finding differential effects when these effects can be defined by a small number of classes of respondents who share a typical relationship between a predictor and an outcome. It is also shown that the comparison between regression mixture models and interactions becomes substantially more complex as the number of classes increases. It is argued that regression interactions are well suited for direct tests of specific hypotheses about differential effects and regression mixtures provide a useful approach for exploring effect heterogeneity given adequate samples and study design. PMID:26556903

  20. Model Checking for Verification of Interactive Health IT Systems

    PubMed Central

    Butler, Keith A.; Mercer, Eric; Bahrami, Ali; Tao, Cui

    2015-01-01

    Rigorous methods for design and verification of health IT systems have lagged far behind their proliferation. The inherent technical complexity of healthcare, combined with the added complexity of health information technology makes their resulting behavior unpredictable and introduces serious risk. We propose to mitigate this risk by formalizing the relationship between HIT and the conceptual work that increasingly typifies modern care. We introduce new techniques for modeling clinical workflows and the conceptual products within them that allow established, powerful modeling checking technology to be applied to interactive health IT systems. The new capability can evaluate the workflows of a new HIT system performed by clinicians and computers to improve safety and reliability. We demonstrate the method on a patient contact system to demonstrate model checking is effective for interactive systems and that much of it can be automated. PMID:26958166

  1. Using Agent Based Modeling (ABM) to Develop Cultural Interaction Simulations

    NASA Technical Reports Server (NTRS)

    Drucker, Nick; Jones, Phillip N.

    2012-01-01

    Today, most cultural training is based on or built around "cultural engagements" or discrete interactions between the individual learner and one or more cultural "others". Often, success in the engagement is the end or the objective. In reality, these interactions usually involve secondary and tertiary effects with potentially wide ranging consequences. The concern is that learning culture within a strict engagement context might lead to "checklist" cultural thinking that will not empower learners to understand the full consequence of their actions. We propose the use of agent based modeling (ABM) to collect, store, and, simulating the effects of social networks, promulgate engagement effects over time, distance, and consequence. The ABM development allows for rapid modification to re-create any number of population types, extending the applicability of the model to any requirement for social modeling.

  2. Interaction of sulpiride and serum albumin: Modeling from spectrofluorimetric data

    NASA Astrophysics Data System (ADS)

    Fragoso, Viviane Muniz da Silva; Silva, Dilson

    2015-12-01

    We have applied the fluorescence quenching modeling to study the process of interaction of sulpiride with human serum albumin (HSA) and bovine (BSA). Albumin is more abundant protein in blood and it emits fluorescence when excited by 260-295 nm. Sulpiride is an atypical antipsychotic used in the treatment of many psychiatric disorders. As sulpiride is fluorescent, we developed a mathematical model to analyzing the interaction of two fluorescent substances. This model was able to separate the albumin fluorescence from the quencher fluorescence. Results have shown that sulpiride quenches the fluorescence of both albumins by a static process, due to the complex formation drugalbumin. The association constants calculated for sulpiride-HSA was 2.20 (± 0.08) × 104 M-1 at 37° C, and 5.46 (± 0.20) × 104 M-1, 25 ° C, and the primary binding site to sulpiride in the albumin is located closer to the subdomain IB.

  3. MESOI: an interactive Lagrangian trajectory puff diffusion model

    SciTech Connect

    Ramsdell, J.V.; Athey, G.F.

    1981-12-01

    MESOI is an interactive Lagrangian trajectory puff diffusion model based on an earlier model by Start and Wendell at the Air Resources Laboratory Field Office at Idaho Falls, Idaho. Puff trajectories are determined using spatially and temporally varying wind fields. Diffusion in the puffs is computed as a function of distance traveled and atmospheric stability. Exposures are computed at nodes of a 31 by 31 grid. There is also provision for interpolation of short term exposures at off-grid locations. This report discusses: the theoretical bases of the model, the numerical approach used in the model, and the sensitivity and accuracy of the model. It contains a description of the computer program and a listing of the code. MESOI is written in FORTRAN. A companion report (Athey, Allwine and Ramsdell, 1981) contains a user's guide to MESOI and documents utility programs that maintain the data files needed by the model.

  4. A model of interaction between anticorruption authority and corruption groups

    SciTech Connect

    Neverova, Elena G.; Malafeyef, Oleg A.

    2015-03-10

    The paper provides a model of interaction between anticorruption unit and corruption groups. The main policy functions of the anticorruption unit involve reducing corrupt practices in some entities through an optimal approach to resource allocation and effective anticorruption policy. We develop a model based on Markov decision-making process and use Howard’s policy-improvement algorithm for solving an optimal decision strategy. We examine the assumption that corruption groups retaliate against the anticorruption authority to protect themselves. This model was implemented through stochastic game.

  5. Analysis of Geophysical Data Bases and Models for Spacecraft Interactions.

    DTIC Science & Technology

    1986-10-31

    electrons, protons, ions (major species), and measured dose. - Evaluation of magnetic field models (Delta B Model). - Quasi- static Data Bases, Analysis ...AIB4 889 ANALYSIS OF GEOPHYSICRL DATA BASES AND MODELS FOR 1/3 SPACECRAFT INTERACTIONS(U) RADEX INC CARLISLE MA J N BAS ET AL 31 OCT 86 AFGL-TR-86...1114 11116 MICROCOPY RESOLUTION TEST CHART NATI()NAL BUREAU flE SIANDARD % 43 A oJ P=I -- % AFGL-TR-86-0221 0 00 ANALYSIS OF GEOPHYSICAL DATA BASES

  6. Mathematical Modeling of Tumor Cell Growth and Immune System Interactions

    NASA Astrophysics Data System (ADS)

    Rihan, Fathalla A.; Safan, Muntaser; Abdeen, Mohamed A.; Abdel-Rahman, Duaa H.

    In this paper, we provide a family of ordinary and delay differential equations to describe the dynamics of tumor-growth and immunotherapy interactions. We explore the effects of adoptive cellular immunotherapy on the model and describe under what circumstances the tumor can be eliminated. The possibility of clearing the tumor, with a strategy, is based on two parameters in the model: the rate of influx of the effector cells, and the rate of influx of IL2. The critical tumor-growth rate, below which endemic tumor does not exist, has been found. One can use the model to make predictions about tumor-dormancy.

  7. Stochastic waves in a Brusselator model with nonlocal interaction.

    PubMed

    Biancalani, Tommaso; Galla, Tobias; McKane, Alan J

    2011-08-01

    We show that intrinsic noise can induce spatiotemporal phenomena such as Turing patterns and traveling waves in a Brusselator model with nonlocal interaction terms. In order to predict and to characterize these stochastic waves we analyze the nonlocal model using a system-size expansion. The resulting theory is used to calculate the power spectra of the stochastic waves analytically and the outcome is tested successfully against simulations. We discuss the possibility that nonlocal models in other areas, such as epidemic spread or social dynamics, may contain similar stochastically induced patterns.

  8. A nonlinear Bloch model for Coulomb interaction in quantum dots

    SciTech Connect

    Bidegaray-Fesquet, Brigitte Keita, Kole

    2014-02-15

    In this paper, we first derive a Coulomb Hamiltonian for electron–electron interaction in quantum dots in the Heisenberg picture. Then we use this Hamiltonian to enhance a Bloch model, which happens to be nonlinear in the density matrix. The coupling with Maxwell equations in case of interaction with an electromagnetic field is also considered from the Cauchy problem point of view. The study is completed by numerical results and a discussion about the advisability of neglecting intra-band coherences, as is done in part of the literature.

  9. Modeling variation in interaction strength between barnacles and fucoids.

    PubMed

    Kordas, Rebecca L; Dudgeon, Steve

    2009-01-01

    The strength by which species interact can vary throughout their ontogeny, as environments vary in space and time, and with the density of their populations. Characterizing strengths of interaction in situ for even a small number of species is logistically difficult and may apply only to those conditions under which the estimates were derived. We sought to combine data from field experiments estimating interaction strength of life stages of the barnacle, Semibalanus balanoides, on germlings of Ascophyllum nodosum, with a model that explored the consequences of variability at per capita and per population levels to the abundance of year-old algal recruits. We further simulated how this interaction affected fucoid germling abundance as the timing of their respective settlements varied relative to one another, as occurs regionally across the Gulf of Maine, USA. Juvenile S. balanoides have a weak estimated per capita effect on germlings. Germling populations are sensitive to variation in per capita effects of juvenile barnacles because of the typically large population sizes of the latter. However, high mortality of juvenile barnacles weakens the population interaction strength over time. Adult barnacles probably weakly facilitate fucoid germlings, but greater survival of adults sustains the strength of that interaction at the population level. Germling abundance is positively associated with densities of adult barnacles and negatively associated with that of juvenile barnacles. Metamorphosing cyprid larvae have the strongest per capita effect on germling abundance, but the interaction between the two stages is so short-lived that germling abundance is altered little. Variation in the timing of barnacle and A. nodosum settlement relative to one another had very little influence on the abundance of yearling germlings. Interactions between barnacles and germlings may influence the demographic structure of A. nodosum populations and the persistence of fucoid

  10. Web-based Interactive Landform Simulation Model - Grand Canyon

    NASA Astrophysics Data System (ADS)

    Luo, W.; Pelletier, J. D.; Duffin, K.; Ormand, C. J.; Hung, W.; Iverson, E. A.; Shernoff, D.; Zhai, X.; Chowdary, A.

    2013-12-01

    Earth science educators need interactive tools to engage and enable students to better understand how Earth systems work over geologic time scales. The evolution of landforms is ripe for interactive, inquiry-based learning exercises because landforms exist all around us. The Web-based Interactive Landform Simulation Model - Grand Canyon (WILSIM-GC, http://serc.carleton.edu/landform/) is a continuation and upgrade of the simple cellular automata (CA) rule-based model (WILSIM-CA, http://www.niu.edu/landform/) that can be accessed from anywhere with an Internet connection. Major improvements in WILSIM-GC include adopting a physically based model and the latest Java technology. The physically based model is incorporated to illustrate the fluvial processes involved in land-sculpting pertaining to the development and evolution of one of the most famous landforms on Earth: the Grand Canyon. It is hoped that this focus on a famous and specific landscape will attract greater student interest and provide opportunities for students to learn not only how different processes interact to form the landform we observe today, but also how models and data are used together to enhance our understanding of the processes involved. The latest development in Java technology (such as Java OpenGL for access to ubiquitous fast graphics hardware, Trusted Applet for file input and output, and multithreaded ability to take advantage of modern multi-core CPUs) are incorporated into building WILSIM-GC and active, standards-aligned curricula materials guided by educational psychology theory on science learning will be developed to accompany the model. This project is funded NSF-TUES program.

  11. Forecast improvement by interactive ensemble of atmospheric models

    NASA Astrophysics Data System (ADS)

    Basnarkov, L.; Duane, G. S.; Kocarev, L.

    2013-12-01

    The advances in weather forecast traditionally have been based on two lines of improvement: 1 - deepening the understanding of physical phenomena that underlies the atmospheric dynamics; and 2 - steady increase in computer power that enables use of finer grid resolution. The meteorological centers model dynamics of the atmosphere with the same basic physical laws, but sometimes take different approaches in capturing small-scale phenomena and generally use different grid sizes. As a result there are dozens operational models around the globe with various parameterizations of the unresolved processes. Newest attempts in forecast improvements are based on using ensemble prediction. Multiple outputs are taken from runs with perturbed initial conditions, or perturbed parameter values. A novel paradigm is exploiting dynamical exchange of variables between simultaneously running models. There are already simulations of models exchanging fluxes between ocean and atmospheric models, but examples with direct coupling of different atmospheric models are rather new. Within this approach the coupling schemes can be different, but as simplest appear those that combine corresponding dynamical variables or tendency components. In this work we present results with an artificial toy model-Lorenz 96 model. To make more faithful example as reality (the atmosphere) is considered one Lorenz 96 class III system, while as its imperfect models are taken three class II systems that have different forcing terms. These resemble the models used in three different meteorological centers. The interactive ensemble has tendency that is weighted combination of the individual models' tendencies. The weights are obtained with statistical techniques based on past observations that target to minimize the mismatch between the truth's and interactive ensemble's tendencies. By means of anomaly correlation it is numerically verified that this ensemble has longer range of forecast than the individual models.

  12. Deciphering Supramolecular Structures with Protein-Protein Interaction Network Modeling

    PubMed Central

    Tsuji, Toshiyuki; Yoda, Takao; Shirai, Tsuyoshi

    2015-01-01

    Many biological molecules are assembled into supramolecules that are essential to perform complicated functions in the cell. However, experimental information about the structures of supramolecules is not sufficient at this point. We developed a method of predicting and modeling the structures of supramolecules in a biological network by combining structural data of the Protein Data Bank (PDB) and interaction data in IntAct databases. Templates for binary complexes in IntAct were extracted from PDB. Modeling was attempted by assembling binary complexes with superposed shared subunits. A total of 3,197 models were constructed, and 1,306 (41% of the total) contained at least one subunit absent from experimental structures. The models also suggested 970 (25% of the total) experimentally undetected subunit interfaces, and 41 human disease-related amino acid variants were mapped onto these model-suggested interfaces. The models demonstrated that protein-protein interaction network modeling is useful to fill the information gap between biological networks and structures. PMID:26549015

  13. Modeling the interaction between flow and highly flexible aquatic vegetation

    NASA Astrophysics Data System (ADS)

    Dijkstra, J. T.; Uittenbogaard, R. E.

    2010-12-01

    Aquatic vegetation has an important role in estuaries and rivers by acting as bed stabilizer, filter, food source, and nursing area. However, macrophyte populations worldwide are under high anthropogenic pressure. Protection and restoration efforts will benefit from more insight into the interaction between vegetation, currents, waves, and sediment transport. Most aquatic plants are very flexible, implying that their shape and hence their drag and turbulence production depend on the flow conditions. We have developed a numerical simulation model that describes this dynamic interaction between very flexible vegetation and a time-varying flow, using the sea grass Zostera marina as an example. The model consists of two parts: an existing 1DV k-ɛ turbulence model simulating the flow combined with a new model simulating the bending of the plants, based on a force balance that takes account of both vegetation position and buoyancy. We validated this model using observations of positions of flexible plastic strips and of the forces they are subjected to, as well as hydrodynamic measurements. The model predicts important properties like the forces on plants, flow velocity profiles, and turbulence characteristics well. Although the validation data are limited, the results are sufficiently encouraging to consider our model to be of generic value in studying flow processes in fields of flexible vegetation.

  14. Bayesian Genomic Prediction with Genotype × Environment Interaction Kernel Models

    PubMed Central

    Cuevas, Jaime; Crossa, José; Montesinos-López, Osval A.; Burgueño, Juan; Pérez-Rodríguez, Paulino; de los Campos, Gustavo

    2016-01-01

    The phenomenon of genotype × environment (G × E) interaction in plant breeding decreases selection accuracy, thereby negatively affecting genetic gains. Several genomic prediction models incorporating G × E have been recently developed and used in genomic selection of plant breeding programs. Genomic prediction models for assessing multi-environment G × E interaction are extensions of a single-environment model, and have advantages and limitations. In this study, we propose two multi-environment Bayesian genomic models: the first model considers genetic effects (u) that can be assessed by the Kronecker product of variance–covariance matrices of genetic correlations between environments and genomic kernels through markers under two linear kernel methods, linear (genomic best linear unbiased predictors, GBLUP) and Gaussian (Gaussian kernel, GK). The other model has the same genetic component as the first model (u) plus an extra component, f, that captures random effects between environments that were not captured by the random effects u. We used five CIMMYT data sets (one maize and four wheat) that were previously used in different studies. Results show that models with G × E always have superior prediction ability than single-environment models, and the higher prediction ability of multi-environment models with u and f over the multi-environment model with only u occurred 85% of the time with GBLUP and 45% of the time with GK across the five data sets. The latter result indicated that including the random effect f is still beneficial for increasing prediction ability after adjusting by the random effect u. PMID:27793970

  15. Universal stochastic series expansion algorithm for Heisenberg model and Bose-Hubbard model with interaction.

    PubMed

    Zyubin, M V; Kashurnikov, V A

    2004-03-01

    We propose a universal stochastic series expansion (SSE) method for the simulation of the Heisenberg model with arbitrary spin and the Bose-Hubbard model with interaction. We report the calculations involving soft-core bosons with interaction by the SSE method. Moreover, we develop a simple procedure for increased efficiency of the algorithm. From calculation of integrated autocorrelation times we conclude that the method is efficient for both models and essentially eliminates the critical slowing down problem.

  16. Shell-model phenomenology of low-momentum interactions

    NASA Astrophysics Data System (ADS)

    Schwenk, Achim; Zuker, Andrés P.

    2006-12-01

    The first detailed comparison of the low-momentum interaction Vlowk with G matrices is presented. We use overlaps to measure quantitatively the similarity of shell-model matrix elements for different cutoffs and oscillator frequencies. Over a wide range, all sets of Vlowk matrix elements can be approximately obtained from a universal set by a simple scaling. In an oscillator mean-field approach, Vlowk reproduces satisfactorily many features of the single-particle and single-hole spectra on closed-shell nuclei, in particular through remarkably good splittings between spin-orbit partners on top of harmonic oscillator closures. The main deficiencies of pure two-nucleon interactions are associated with binding energies and with the failure to ensure magicity for the extruder-intruder closures. Here, calculations including three-nucleon interactions are most needed. Vlowk makes it possible to define directly a meaningful unperturbed monopole Hamiltonian, for which the inclusion of three-nucleon forces is tractable.

  17. Rational solitons of wave resonant-interaction models

    NASA Astrophysics Data System (ADS)

    Degasperis, Antonio; Lombardo, Sara

    2013-11-01

    Integrable models of resonant interaction of two or more waves in 1+1 dimensions are known to be of applicative interest in several areas. Here we consider a system of three coupled wave equations which includes as special cases the vector nonlinear Schrödinger equations and the equations describing the resonant interaction of three waves. The Darboux-Dressing construction of soliton solutions is applied under the condition that the solutions have rational, or mixed rational-exponential, dependence on coordinates. Our algebraic construction relies on the use of nilpotent matrices and their Jordan form. We systematically search for all bounded rational (mixed rational-exponential) solutions and find a broad family of such solutions of the three wave resonant interaction equations.

  18. Adapting GOMS to Model Human-Robot Interaction

    SciTech Connect

    Drury, Jill; Scholtz, Jean; Kieras, David

    2007-03-09

    Human-robot interaction (HRI) has been maturing in tandem with robots’ commercial success. In the last few years HRI researchers have been adopting—and sometimes adapting—human-computer interaction (HCI) evaluation techniques to assess the efficiency and intuitiveness of HRI designs. For example, Adams (2005) used Goal Directed Task Analysis to determine the interaction needs of officers from the Nashville Metro Police Bomb Squad. Scholtz et al. (2004) used Endsley’s (1988) Situation Awareness Global Assessment Technique to determine robotic vehicle supervisors’ awareness of when vehicles were in trouble and thus required closer monitoring or intervention. Yanco and Drury (2004) employed usability testing to determine (among other things) how well a search-andrescue interface supported use by first responders. One set of HCI tools that has so far seen little exploration in the HRI domain, however, is the class of modeling and evaluation techniques known as formal methods.

  19. Computational Modeling of Arc-Slag Interaction in DC Furnaces

    NASA Astrophysics Data System (ADS)

    Reynolds, Quinn G.

    2017-02-01

    The plasma arc is central to the operation of the direct-current arc furnace, a unit operation commonly used in high-temperature processing of both primary ores and recycled metals. The arc is a high-velocity, high-temperature jet of ionized gas created and sustained by interactions among the thermal, momentum, and electromagnetic fields resulting from the passage of electric current. In addition to being the primary source of thermal energy, the arc jet also couples mechanically with the bath of molten process material within the furnace, causing substantial splashing and stirring in the region in which it impinges. The arc's interaction with the molten bath inside the furnace is studied through use of a multiphase, multiphysics computational magnetohydrodynamic model developed in the OpenFOAM® framework. Results from the computational solver are compared with empirical correlations that account for arc-slag interaction effects.

  20. Computational Modeling of Arc-Slag Interaction in DC Furnaces

    NASA Astrophysics Data System (ADS)

    Reynolds, Quinn G.

    2016-11-01

    The plasma arc is central to the operation of the direct-current arc furnace, a unit operation commonly used in high-temperature processing of both primary ores and recycled metals. The arc is a high-velocity, high-temperature jet of ionized gas created and sustained by interactions among the thermal, momentum, and electromagnetic fields resulting from the passage of electric current. In addition to being the primary source of thermal energy, the arc jet also couples mechanically with the bath of molten process material within the furnace, causing substantial splashing and stirring in the region in which it impinges. The arc's interaction with the molten bath inside the furnace is studied through use of a multiphase, multiphysics computational magnetohydrodynamic model developed in the OpenFOAM® framework. Results from the computational solver are compared with empirical correlations that account for arc-slag interaction effects.

  1. Model-independent analyses of dark-matter particle interactions

    SciTech Connect

    Anand, Nikhil; Fitzpatrick, A. Liam; Haxton, W. C.

    2015-03-24

    A model-independent treatment of dark-matter particle elastic scattering has been developed, yielding the most general interaction for WIMP-nucleon low-energy scattering, and the resulting amplitude has been embedded into the nucleus, taking into account the selection rules imposed by parity and time-reversal. One finds that, in contrast to the usual spin-independent/spin-dependent (SI/SD) formulation, the resulting cross section contains six independent nuclear response functions, three of which are associated with possible velocity-dependent interactions. We find that current experiments are four orders of magnitude more sensitive to derivative couplings than is apparent in the standard SI/SD treatment, which necessarily associated such interactions with cross sections proportional to v2T ~ 10⁻⁶, where vT is the WIMP velocity relative to the center of mass of the nuclear target.

  2. Model-independent analyses of dark-matter particle interactions

    DOE PAGES

    Anand, Nikhil; Fitzpatrick, A. Liam; Haxton, W. C.

    2015-03-24

    A model-independent treatment of dark-matter particle elastic scattering has been developed, yielding the most general interaction for WIMP-nucleon low-energy scattering, and the resulting amplitude has been embedded into the nucleus, taking into account the selection rules imposed by parity and time-reversal. One finds that, in contrast to the usual spin-independent/spin-dependent (SI/SD) formulation, the resulting cross section contains six independent nuclear response functions, three of which are associated with possible velocity-dependent interactions. We find that current experiments are four orders of magnitude more sensitive to derivative couplings than is apparent in the standard SI/SD treatment, which necessarily associated such interactions withmore » cross sections proportional to v2T ~ 10⁻⁶, where vT is the WIMP velocity relative to the center of mass of the nuclear target.« less

  3. A responsive finite element method to aid interactive geometric modeling.

    PubMed

    Umetani, N; Takayama, K; Mitani, J; Igarashi, T

    2011-01-01

    Current computer-aided engineering systems use numerical-simulation methods mainly as offline verification tools to reject designs that don't satisfy the required constraints, rather than as tools to guide users toward better designs. However, integrating real-time finite element method (FEM) into interactive geometric modeling can provide user guidance. During interactive editing, real-time feedback from numerical simulation guides users toward an improved design without tedious trial-and-error iterations. Careful reuse of previous computation results, such as meshes and matrices, on the basis of speed and accuracy trade-offs, have helped produce fast FEM analysis during interactive editing. Several 2D example applications and informal user studies show this approach's effectiveness. Such tools could help nonexpert users design objects that satisfy physical constraints and help those users understand the underlying physical properties.

  4. Models of atmosphere-ecosystem-hydrology interactions: Approaches and testing

    NASA Technical Reports Server (NTRS)

    Schimel, David S.

    1992-01-01

    Interactions among the atmosphere, terrestrial ecosystems, and the hydrological cycle have been the subject of investigation for many years, although most of the research has had a regional focus. The topic is broad, including the effects of climate and hydrology on vegetation, the effects of vegetation on hydrology, the effects of the hydrological cycle on the atmosphere, and interactions of the cycles via material flux such as solutes and trace gases. The intent of this paper is to identify areas of critical uncertainty, discuss modeling approaches to resolving those problems, and then propose techniques for testing. I consider several interactions specifically to illustrate the range of problems. These areas are as follows: (1) cloud parameterizations and the land surface, (2) soil moisture, and (3) the terrestrial carbon cycle.

  5. Modeling decision support rule interactions in a clinical setting.

    PubMed

    Sordo, Margarita; Rocha, Beatriz H; Morales, Alfredo A; Maviglia, Saverio M; Oglio, Elisa Dell'Oglio; Fairbanks, Amanda; Aroy, Teal; Dubois, David; Bouyer-Ferullo, Sharon; Rocha, Roberto A

    2013-01-01

    Traditionally, rule interactions are handled at implementation time through rule task properties that control the order in which rules are executed. By doing so, knowledge about the behavior and interactions of decision rules is not captured at modeling time. We argue that this is important knowledge that should be integrated in the modeling phase. In this project, we build upon current work on a conceptual schema to represent clinical knowledge for decision support in the form of if then rules. This schema currently captures provenance of the clinical content, context where such content is actionable (i.e. constraints) and the logic of the rule itself. For this project, we borrowed concepts from both the Semantic Web (i.e., Ontologies) and Complex Adaptive Systems (CAS), to explore a conceptual approach for modeling rule interactions in an enterprise-wide clinical setting. We expect that a more comprehensive modeling will facilitate knowledge authoring, editing and update; foster consistency in rules implementation and maintenance; and develop authoritative knowledge repositories to promote quality, safety and efficacy of healthcare.

  6. Genomic Prediction of Genotype × Environment Interaction Kernel Regression Models.

    PubMed

    Cuevas, Jaime; Crossa, José; Soberanis, Víctor; Pérez-Elizalde, Sergio; Pérez-Rodríguez, Paulino; Campos, Gustavo de Los; Montesinos-López, O A; Burgueño, Juan

    2016-11-01

    In genomic selection (GS), genotype × environment interaction (G × E) can be modeled by a marker × environment interaction (M × E). The G × E may be modeled through a linear kernel or a nonlinear (Gaussian) kernel. In this study, we propose using two nonlinear Gaussian kernels: the reproducing kernel Hilbert space with kernel averaging (RKHS KA) and the Gaussian kernel with the bandwidth estimated through an empirical Bayesian method (RKHS EB). We performed single-environment analyses and extended to account for G × E interaction (GBLUP-G × E, RKHS KA-G × E and RKHS EB-G × E) in wheat ( L.) and maize ( L.) data sets. For single-environment analyses of wheat and maize data sets, RKHS EB and RKHS KA had higher prediction accuracy than GBLUP for all environments. For the wheat data, the RKHS KA-G × E and RKHS EB-G × E models did show up to 60 to 68% superiority over the corresponding single environment for pairs of environments with positive correlations. For the wheat data set, the models with Gaussian kernels had accuracies up to 17% higher than that of GBLUP-G × E. For the maize data set, the prediction accuracy of RKHS EB-G × E and RKHS KA-G × E was, on average, 5 to 6% higher than that of GBLUP-G × E. The superiority of the Gaussian kernel models over the linear kernel is due to more flexible kernels that accounts for small, more complex marker main effects and marker-specific interaction effects.

  7. A Conceptual Model for Extratropical Atmosphere-ocean Interaction

    NASA Astrophysics Data System (ADS)

    Zhao, B.; Reichler, T.

    2015-12-01

    Equipped with the current understanding for atmosphere-ocean interaction, we build a simple physically-based system of coupled equations to portray the relationships among major atmospheric and oceanic modes, including the NAO, AMO, AMOC, ENSO and stratospheric NAM. The simple model reproduces the strongly timescale-dependent character of the relationships, which changes in strength and direction on scales ranging from days to centuries. Another emphasis is placed on explicitly resolving the air-sea heat fluxes as a function of timescale to provide insight into the coupling between ocean and atmosphere. In constructing and testing the simple model we make use of a multi-millennium-long control integration with a fully coupled climate model. Cross-correlation, spectral analysis and inverse methods are employed to characterize important aspects of the interactions in the full and simple models. It is found that, a) Bjerknes' conjecture on ocean-atmosphere coupling, that is the atmosphere drives climate on high frequencies (days to months) while the ocean acts as the main source of climate variability on interannual and longer timescales, is confirmed; b) the AMOC can be readily understood as a harmonic oscillator driven by the NAO; c) the two-way interaction between NAO and AMO, and also the influence of ENSO on both NAO and AMO are essential for reproducing important correlation features; and d) the consideration of heat fluxes provides additional explanatory power to our model. Our approach not only helps to clarify our understanding for the nature of the atmosphere-ocean interaction problem but also raises new and intriguing questions for future research.

  8. Modelling social interaction as perceptual crossing: an investigation into the dynamics of the interaction process

    NASA Astrophysics Data System (ADS)

    Froese, Tom; Di Paolo, Ezequiel A.

    2010-03-01

    This paper continues efforts to establish a mutually informative dialogue between psychology and evolutionary robotics in order to investigate the dynamics of social interaction. We replicate a recent simulation model of a minimalist experiment in perceptual crossing and confirm the results with significantly simpler artificial agents. A series of psycho-physical tests of their behaviour informs a hypothetical circuit model of their internal operation. However, a detailed study of the actual internal dynamics reveals this circuit model to be unfounded, thereby offering a tale of caution for those hypothesising about sub-personal processes in terms of behavioural observations. In particular, it is shown that the behaviour of the agents largely emerges out of the interaction process itself rather than being an individual achievement alone. We also extend the original simulation model in two novel directions in order to test further the extent to which perceptual crossing between agents can self-organise in a robust manner. These modelling results suggest new hypotheses that can become the basis for further psychological experiments.

  9. Modeling the Interactions Between Multiple Crack Closure Mechanisms at Threshold

    NASA Technical Reports Server (NTRS)

    Newman, John A.; Riddell, William T.; Piascik, Robert S.

    2003-01-01

    A fatigue crack closure model is developed that includes interactions between the three closure mechanisms most likely to occur at threshold; plasticity, roughness, and oxide. This model, herein referred to as the CROP model (for Closure, Roughness, Oxide, and Plasticity), also includes the effects of out-of plane cracking and multi-axial loading. These features make the CROP closure model uniquely suited for, but not limited to, threshold applications. Rough cracks are idealized here as two-dimensional sawtooths, whose geometry induces mixed-mode crack- tip stresses. Continuum mechanics and crack-tip dislocation concepts are combined to relate crack face displacements to crack-tip loads. Geometric criteria are used to determine closure loads from crack-face displacements. Finite element results, used to verify model predictions, provide critical information about the locations where crack closure occurs.

  10. Stochastic models for large interacting systems and related correlation inequalities

    PubMed Central

    Liggett, Thomas M.

    2010-01-01

    A very large and active part of probability theory is concerned with the formulation and analysis of models for the evolution of large systems arising in the sciences, including physics and biology. These models have in their description randomness in the evolution rules, and interactions among various parts of the system. This article describes some of the main models in this area, as well as some of the major results about their behavior that have been obtained during the past 40 years. An important technique in this area, as well as in related parts of physics, is the use of correlation inequalities. These express positive or negative dependence between random quantities related to the model. In some types of models, the underlying dependence is positive, whereas in others it is negative. We give particular attention to these issues, and to applications of these inequalities. Among the applications are central limit theorems that give convergence to a Gaussian distribution. PMID:20826441

  11. Modeling relaxor characteristics in systems of interacting dipoles

    NASA Astrophysics Data System (ADS)

    Kliem, Herbert; Leschhorn, Andreas

    2016-12-01

    We present a model which derives typical relaxor characteristics from simple and plausible microscopic assumptions. The model is based on charges which fluctuate thermally activated in double well potentials. The double well potentials are asymmetric due to disorder in the system. The electrostatic interaction between the charges is considered via a mean field approach. This model yields the typical relaxor features: we find high susceptibilities in a broad temperature range with dynamics following the Vogel-Fulcher law. In the framework of the model no spontaneous polarization arises at cooling without strong external field in accordance to experimental findings for relaxors. Furthermore the model yields hysteresis loops which depend on the amplitude of the external field and which become more and more thin and deformed above the maximum temperature of the susceptibility.

  12. Brachypodium as an emerging model for cereal–pathogen interactions

    PubMed Central

    Fitzgerald, Timothy L.; Powell, Jonathan J.; Schneebeli, Katharina; Hsia, M. Mandy; Gardiner, Donald M.; Bragg, Jennifer N.; McIntyre, C. Lynne; Manners, John M.; Ayliffe, Mick; Watt, Michelle; Vogel, John P.; Henry, Robert J.; Kazan, Kemal

    2015-01-01

    Background Cereal diseases cause tens of billions of dollars of losses annually and have devastating humanitarian consequences in the developing world. Increased understanding of the molecular basis of cereal host–pathogen interactions should facilitate development of novel resistance strategies. However, achieving this in most cereals can be challenging due to large and complex genomes, long generation times and large plant size, as well as quarantine and intellectual property issues that may constrain the development and use of community resources. Brachypodium distachyon (brachypodium) with its small, diploid and sequenced genome, short generation time, high transformability and rapidly expanding community resources is emerging as a tractable cereal model. Scope Recent research reviewed here has demonstrated that brachypodium is either susceptible or partially susceptible to many of the major cereal pathogens. Thus, the study of brachypodium–pathogen interactions appears to hold great potential to improve understanding of cereal disease resistance, and to guide approaches to enhance this resistance. This paper reviews brachypodium experimental pathosystems for the study of fungal, bacterial and viral cereal pathogens; the current status of the use of brachypodium for functional analysis of cereal disease resistance; and comparative genomic approaches undertaken using brachypodium to assist characterization of cereal resistance genes. Additionally, it explores future prospects for brachypodium as a model to study cereal–pathogen interactions. Conclusions The study of brachypodium–pathogen interactions appears to be a productive strategy for understanding mechanisms of disease resistance in cereal species. Knowledge obtained from this model interaction has strong potential to be exploited for crop improvement. PMID:25808446

  13. Modeling interactions of Hg(II) and bauxitic soils.

    PubMed

    Weerasooriya, Rohan; Tobschall, Heinz J; Bandara, Atula

    2007-11-01

    The adsorptive interactions of Hg(II) with gibbsite-rich soils (hereafter SOIL-g) were modeled by 1-pK surface complexation theory using charge distribution multi-site ion competition model (CD MUSIC) incorporating basic Stern layer model (BSM) to account for electrostatic effects. The model calibrations were performed for the experimental data of synthetic gibbsite-Hg(II) adsorption. When [NaNO(3)] > or = 0.01M, the Hg(II) adsorption density values, of gibbsite, Gamma(Hg(II)), showed a negligible variation with ionic strength. However, Gamma(Hg(II)) values show a marked variation with the [Cl(-)]. When [Cl(-)] > or = 0.01M, the Gamma(Hg(II)) values showed a significant reduction with the pH. The Hg(II) adsorption behavior in NaNO(3) was modeled assuming homogeneous solid surface. The introduction of high affinity sites, i.e., >Al(s)OH at a low concentration (typically about 0.045 sites nm(-2)) is required to model Hg(II) adsorption in NaCl. According to IR spectroscopic data, the bauxitic soil (SOIL-g) is characterized by gibbsite and bayerite. These mineral phases were not treated discretely in modeling of Hg(II) and soil interactions. The CD MUSIC/BSM model combination can be used to model Hg(II) adsorption on bauxitic soil. The role of organic matter seems to play a role on Hg(II) binding when pH>8. The Hg(II) adsorption in the presence of excess Cl(-) ions required the selection of high affinity sites in modeling.

  14. Modeling the intracellular pathogen-immune interaction with cure rate

    NASA Astrophysics Data System (ADS)

    Dubey, Balram; Dubey, Preeti; Dubey, Uma S.

    2016-09-01

    Many common and emergent infectious diseases like Influenza, SARS, Hepatitis, Ebola etc. are caused by viral pathogens. These infections can be controlled or prevented by understanding the dynamics of pathogen-immune interaction in vivo. In this paper, interaction of pathogens with uninfected and infected cells in presence or absence of immune response are considered in four different cases. In the first case, the model considers the saturated nonlinear infection rate and linear cure rate without absorption of pathogens into uninfected cells and without immune response. The next model considers the effect of absorption of pathogens into uninfected cells while all other terms are same as in the first case. The third model incorporates innate immune response, humoral immune response and Cytotoxic T lymphocytes (CTL) mediated immune response with cure rate and without absorption of pathogens into uninfected cells. The last model is an extension of the third model in which the effect of absorption of pathogens into uninfected cells has been considered. Positivity and boundedness of solutions are established to ensure the well-posedness of the problem. It has been found that all the four models have two equilibria, namely, pathogen-free equilibrium point and pathogen-present equilibrium point. In each case, stability analysis of each equilibrium point is investigated. Pathogen-free equilibrium is globally asymptotically stable when basic reproduction number is less or equal to unity. This implies that control or prevention of infection is independent of initial concentration of uninfected cells, infected cells, pathogens and immune responses in the body. The proposed models show that introduction of immune response and cure rate strongly affects the stability behavior of the system. Further, on computing basic reproduction number, it has been found to be minimum for the fourth model vis-a-vis other models. The analytical findings of each model have been exemplified by

  15. Hydrodynamic interaction of two swimming model micro-organisms

    NASA Astrophysics Data System (ADS)

    Ishikawa, Takuji; Simmonds, M. P.; Pedley, T. J.

    2006-12-01

    In order to understand the rheological and transport properties of a suspension of swimming micro-organisms, it is necessary to analyse the fluid-dynamical interaction of pairs of such swimming cells. In this paper, a swimming micro-organism is modelled as a squirming sphere with prescribed tangential surface velocity, referred to as a squirmer. The centre of mass of the sphere may be displaced from the geometric centre (bottom-heaviness). The effects of inertia and Brownian motion are neglected, because real micro-organisms swim at very low Reynolds numbers but are too large for Brownian effects to be important. The interaction of two squirmers is calculated analytically for the limits of small and large separations and is also calculated numerically using a boundary-element method. The analytical and the numerical results for the translational rotational velocities and for the stresslet of two squirmers correspond very well. We sought to generate a database for an interacting pair of squirmers from which one can easily predict the motion of a collection of squirmers. The behaviour of two interacting squirmers is discussed phenomenologically, too. The results for the trajectories of two squirmers show that first the squirmers attract each other, then they change their orientation dramatically when they are in near contact and finally they separate from each other. The effect of bottom-heaviness is considerable. Restricting the trajectories to two dimensions is shown to give misleading results. Some movies of interacting squirmers are available with the online version of the paper.

  16. Interaction of tea tree oil with model and cellular membranes.

    PubMed

    Giordani, Cristiano; Molinari, Agnese; Toccacieli, Laura; Calcabrini, Annarica; Stringaro, Annarita; Chistolini, Pietro; Arancia, Giuseppe; Diociaiuti, Marco

    2006-07-27

    Tea tree oil (TTO) is the essential oil steam-distilled from Melaleuca alternifolia, a species of northern New South Wales, Australia. It exhibits a broad-spectrum antimicrobial activity and an antifungal activity. Only recently has TTO been shown to inhibit the in vitro growth of multidrug resistant (MDR) human melanoma cells. It has been suggested that the effect of TTO on tumor cells could be mediated by its interaction with the plasma membrane, most likely by inducing a reorganization of lipid architecture. In this paper we report biophysical and structural results obtained using simplified planar model membranes (Langmuir films) mimicking lipid "rafts". We also used flow cytometry analysis (FCA) and freeze-fracturing transmission electron microscopy to investigate the effects of TTO on actual MDR melanoma cell membranes. Thermodynamic (compression isotherms and adsorption kinetics) and structural (Brewster angle microscopy) investigation of the lipid monolayers clearly indicates that TTO interacts preferentially with the less ordered DPPC "sea" and that it does not alter the more ordered lipid "rafts". Structural observations, performed by freeze fracturing, confirm that TTO interacts with the MDR melanoma cell plasma membrane. Moreover, experiments performed by FCA demonstrate that TTO does not interfere with the function of the MDR drug transporter P-gp. We therefore propose that the effect exerted on MDR melanoma cells is mediated by the interaction with the fluid DPPC phase, rather than with the more organized "rafts" and that this interaction preferentially influences the ATP-independent antiapoptotic activity of P-gp likely localized outside "rafts".

  17. Exacerbating the Cosmological Constant Problem with Interacting Dark Energy Models.

    PubMed

    Marsh, M C David

    2017-01-06

    Future cosmological surveys will probe the expansion history of the Universe and constrain phenomenological models of dark energy. Such models do not address the fine-tuning problem of the vacuum energy, i.e., the cosmological constant problem (CCP), but can make it spectacularly worse. We show that this is the case for "interacting dark energy" models in which the masses of the dark matter states depend on the dark energy sector. If realized in nature, these models have far-reaching implications for proposed solutions to the CCP that require the number of vacua to exceed the fine-tuning of the vacuum energy density. We show that current estimates of the number of flux vacua in string theory, N_{vac}∼O(10^{272 000}), are far too small to realize certain simple models of interacting dark energy and solve the cosmological constant problem anthropically. These models admit distinctive observational signatures that can be targeted by future gamma-ray observatories, hence making it possible to observationally rule out the anthropic solution to the cosmological constant problem in theories with a finite number of vacua.

  18. Exacerbating the Cosmological Constant Problem with Interacting Dark Energy Models

    NASA Astrophysics Data System (ADS)

    Marsh, M. C. David

    2017-01-01

    Future cosmological surveys will probe the expansion history of the Universe and constrain phenomenological models of dark energy. Such models do not address the fine-tuning problem of the vacuum energy, i.e., the cosmological constant problem (CCP), but can make it spectacularly worse. We show that this is the case for "interacting dark energy" models in which the masses of the dark matter states depend on the dark energy sector. If realized in nature, these models have far-reaching implications for proposed solutions to the CCP that require the number of vacua to exceed the fine-tuning of the vacuum energy density. We show that current estimates of the number of flux vacua in string theory, Nvac˜O (1 0272 000) , are far too small to realize certain simple models of interacting dark energy and solve the cosmological constant problem anthropically. These models admit distinctive observational signatures that can be targeted by future gamma-ray observatories, hence making it possible to observationally rule out the anthropic solution to the cosmological constant problem in theories with a finite number of vacua.

  19. Characterization and modeling of protein protein interaction networks

    NASA Astrophysics Data System (ADS)

    Colizza, Vittoria; Flammini, Alessandro; Maritan, Amos; Vespignani, Alessandro

    2005-07-01

    The recent availability of high-throughput gene expression and proteomics techniques has created an unprecedented opportunity for a comprehensive study of the structure and dynamics of many biological networks. Global proteomic interaction data, in particular, are synthetically represented as undirected networks exhibiting features far from the random paradigm which has dominated past effort in network theory. This evidence, along with the advances in the theory of complex networks, has triggered an intense research activity aimed at exploiting the evolutionary and biological significance of the resulting network's topology. Here we present a review of the results obtained in the characterization and modeling of the yeast Saccharomyces Cerevisiae protein interaction networks obtained with different experimental techniques. We provide a comparative assessment of the topological properties and discuss possible biases in interaction networks obtained with different techniques. We report on dynamical models based on duplication mechanisms that cast the protein interaction networks in the family of dynamically growing complex networks. Finally, we discuss various results and analysis correlating the networks’ topology with the biological function of proteins.

  20. Trilevel interaction design model for pilot part-task training

    SciTech Connect

    Roman, J.H.; Pistone, R.A.; Stoddard, M.L.

    1986-01-01

    Development of effective, scenario-driven training exercises requires both an instructional design and a delivery system that match the subject domain and needs of the students. The Training Research Team at Los Alamos National Laboratory conducts research and development of prototype training systems. One of the Team's efforts is a joint research project, supported with funding and behavioral science guidance from the Army Research Institute, to develop a prototype part-task trainer for student helicopter pilots. The Team designed a ''trilevel interaction'' model and a Level III interactive videodisc delivery system for this project. The model, founded on instructional and psychological theory, should be transferable to other domains where part-task training is appropriate.

  1. Interactive model of urban development in residential areas in Skopje

    NASA Astrophysics Data System (ADS)

    Marina, O.; Masala, E.; Pensa, S.; Stavric, M.

    2012-10-01

    Development of residential areas in Skopje in a period after the 1963 earthquake led to an emergence of continuous pressure to the physical structure of the city. It's essential to analyse, explore and understand the processes that are shaping our city. The study explores interactive tool that exercise the complex analysis of architectural and urban structure within the Skopje's residential areas and proposes a 3D model to investigate local dynamics and best fitting urban indicators for development. Through series of analysis of diverse typologies, programs, spatial and functional configurations of the dwelling within the city, the study presents an effort by use of Interactive Visualization Tool (InViTo) for modeling of urban development to explicate spatial distribution, the process of transformation and acknowledge the regularities and suitability of development of urban form in Skopje's residential area and, in particular, the relationship between functions and its localizations.

  2. Stochastic Local Interaction (SLI) model: Bridging machine learning and geostatistics

    NASA Astrophysics Data System (ADS)

    Hristopulos, Dionissios T.

    2015-12-01

    Machine learning and geostatistics are powerful mathematical frameworks for modeling spatial data. Both approaches, however, suffer from poor scaling of the required computational resources for large data applications. We present the Stochastic Local Interaction (SLI) model, which employs a local representation to improve computational efficiency. SLI combines geostatistics and machine learning with ideas from statistical physics and computational geometry. It is based on a joint probability density function defined by an energy functional which involves local interactions implemented by means of kernel functions with adaptive local kernel bandwidths. SLI is expressed in terms of an explicit, typically sparse, precision (inverse covariance) matrix. This representation leads to a semi-analytical expression for interpolation (prediction), which is valid in any number of dimensions and avoids the computationally costly covariance matrix inversion.

  3. Exploring host–microbiota interactions in animal models and humans

    PubMed Central

    Kostic, Aleksandar D.; Howitt, Michael R.; Garrett, Wendy S.

    2013-01-01

    The animal and bacterial kingdoms have coevolved and coadapted in response to environmental selective pressures over hundreds of millions of years. The meta'omics revolution in both sequencing and its analytic pipelines is fostering an explosion of interest in how the gut microbiome impacts physiology and propensity to disease. Gut microbiome studies are inherently interdisciplinary, drawing on approaches and technical skill sets from the biomedical sciences, ecology, and computational biology. Central to unraveling the complex biology of environment, genetics, and microbiome interaction in human health and disease is a deeper understanding of the symbiosis between animals and bacteria. Experimental model systems, including mice, fish, insects, and the Hawaiian bobtail squid, continue to provide critical insight into how host–microbiota homeostasis is constructed and maintained. Here we consider how model systems are influencing current understanding of host–microbiota interactions and explore recent human microbiome studies. PMID:23592793

  4. Interacting agegraphic dark energy models in phase space

    SciTech Connect

    Lemets, O.A.; Yerokhin, D.A.; Zazunov, L.G. E-mail: denyerokhin@gmail.com

    2011-01-01

    Agegraphic dark energy, has been recently proposed, based on the so-called Karolyhazy uncertainty relation, which arises from quantum mechanics together with general relativity. In the first part of the article we study the original agegraphic dark energy model by including the interaction between agegraphic dark energy and pressureless (dark) matter. The phase space analysis was made and the critical points were found, one of which is the attractor corresponding to an accelerated expanding Universe. Recent observations of near supernova show that the acceleration of Universe decreases. This phenomenon is called the transient acceleration. In the second part of Article we consider the 3-component Universe composed of a scalar field, interacting with the dark matter on the agegraphic dark energy background. We show that the transient acceleration appears in frame of such a model. The obtained results agree with the observations.

  5. Understanding polycaroboxylate interactions with counterions: A molecular modeling approach

    SciTech Connect

    Fitzwater, S.; Freeman, M.B.

    1993-12-31

    Low molecular weight polycarboyxlates, such as poly(acrylic acid), have utility as dispersants in a variety of commercial applications including home laundry detergents, mineral processing and water treatment. In general, counterions (Ca, Mg, Fe, etc.) are unavoidable in these applications and often dictate the polymer composition and molecular weight necessary for successful performance. The authors have been investigating the interaction of polycarboxylates with counterions in order to better understand how that interaction impacts on the dispersant properties of a polymer. Using computer modeling, it can be seen how molecular geometry, molecular dynamics, and the shape/polarity of the molecular surface are affected by counterion binding and polymer composition. The authors can then combine information from the modeling with experimental information and literature concepts to provide a direction toward the synthesis of improved low molecular weight polycarboxylate dispersants.

  6. Turbulence radiation interaction modeling in hydrocarbon pool fire simulations

    SciTech Connect

    BURNS,SHAWN P.

    1999-12-01

    The importance of turbulent fluctuations in temperature and species concentration in thermal radiation transport modeling for combustion applications is well accepted by the radiation transport and combustion communities. A number of experimental and theoretical studies over the last twenty years have shown that fluctuations in the temperature and species concentrations may increase the effective emittance of a turbulent flame by as much as 50% to 300% over the value that would be expected from the mean temperatures and concentrations. With the possibility of such a large effect on the principal mode of heat transfer from a fire, it is extremely important for fire modeling efforts that turbulence radiation interaction be well characterized and possible modeling approaches understood. Toward this end, this report seeks to accomplish three goals. First, the principal turbulence radiation interaction closure terms are defined. Second, an order of magnitude analysis is performed to understand the relative importance of the various closure terms. Finally, the state of the art in turbulence radiation interaction closure modeling is reviewed. Hydrocarbon pool fire applications are of particular interest in this report and this is the perspective from which this review proceeds. Experimental and theoretical analysis suggests that, for this type of heavily sooting flame, the turbulent radiation interaction effect is dominated by the nonlinear dependence of the Planck function on the temperature. Additional effects due to the correlation between turbulent fluctuations in the absorptivity and temperature may be small relative to the Planck function effect for heavily sooting flames. This observation is drawn from a number of experimental and theoretical discussions. Nevertheless, additional analysis and data is needed to validate this observation for heavily sooting buoyancy dominated plumes.

  7. Celiac disease: a model disease for gene-environment interaction.

    PubMed

    Uibo, Raivo; Tian, Zhigang; Gershwin, M Eric

    2011-03-01

    Celiac sprue remains a model autoimmune disease for dissection of genetic and environmental influences on disease progression. The 2010 Congress of Autoimmunity included several key sessions devoted to genetics and environment. Several papers from these symposia were selected for in-depth discussion and publication. This issue is devoted to this theme. The goal is not to discuss genetic and environmental interactions, but rather to focus on key elements of diagnosis, the inflammatory response and the mechanisms of autoimmunity.

  8. Celiac disease: a model disease for gene–environment interaction

    PubMed Central

    Uibo, Raivo; Tian, Zhigang; Gershwin, M Eric

    2011-01-01

    Celiac sprue remains a model autoimmune disease for dissection of genetic and environmental influences on disease progression. The 2010 Congress of Autoimmunity included several key sessions devoted to genetics and environment. Several papers from these symposia were selected for in-depth discussion and publication. This issue is devoted to this theme. The goal is not to discuss genetic and environmental interactions, but rather to focus on key elements of diagnosis, the inflammatory response and the mechanisms of autoimmunity. PMID:21317918

  9. Modeling gas-dust interactions in debris disks

    NASA Astrophysics Data System (ADS)

    Richert, Alex J. W.; Kuchner, Marc J.; Lyra, Wladimir

    2017-01-01

    The discovery of gas in debris disks has raised the question of whether gas-dust interactions can observably affect global disk structure. This has important implications for identifying planets in debris disks, as well as probing dust grain composition, which is key to understanding the habitability of planetary systems. In this dissertation talk, I present two-dimensional global hydrodynamical models of debris disks with gas and discuss the effects of the gas on the global distribution of the dust.

  10. A validation study of a stochastic model of human interaction

    NASA Astrophysics Data System (ADS)

    Burchfield, Mitchel Talmadge

    The purpose of this dissertation is to validate a stochastic model of human interactions which is part of a developmentalism paradigm. Incorporating elements of ancient and contemporary philosophy and science, developmentalism defines human development as a progression of increasing competence and utilizes compatible theories of developmental psychology, cognitive psychology, educational psychology, social psychology, curriculum development, neurology, psychophysics, and physics. To validate a stochastic model of human interactions, the study addressed four research questions: (a) Does attitude vary over time? (b) What are the distributional assumptions underlying attitudes? (c) Does the stochastic model, {-}N{intlimitssbsp{-infty}{infty}}varphi(chi,tau)\\ Psi(tau)dtau, have utility for the study of attitudinal distributions and dynamics? (d) Are the Maxwell-Boltzmann, Fermi-Dirac, and Bose-Einstein theories applicable to human groups? Approximately 25,000 attitude observations were made using the Semantic Differential Scale. Positions of individuals varied over time and the logistic model predicted observed distributions with correlations between 0.98 and 1.0, with estimated standard errors significantly less than the magnitudes of the parameters. The results bring into question the applicability of Fisherian research designs (Fisher, 1922, 1928, 1938) for behavioral research based on the apparent failure of two fundamental assumptions-the noninteractive nature of the objects being studied and normal distribution of attributes. The findings indicate that individual belief structures are representable in terms of a psychological space which has the same or similar properties as physical space. The psychological space not only has dimension, but individuals interact by force equations similar to those described in theoretical physics models. Nonlinear regression techniques were used to estimate Fermi-Dirac parameters from the data. The model explained a high degree

  11. Model-based description of environment interaction for mobile robots

    NASA Astrophysics Data System (ADS)

    Borghi, Giuseppe; Ferrari, Carlo; Pagello, Enrico; Vianello, Marco

    1999-01-01

    We consider a mobile robot that attempts to accomplish a task by reaching a given goal, and interacts with its environment through a finite set of actions and observations. The interaction between robot and environment is modeled by Partially Observable Markov Decision Processes (POMDP). The robot takes its decisions in presence of uncertainty about the current state, by maximizing its reward gained during interactions with the environment. It is able to self-locate into the environment by collecting actions and perception histories during the navigation. To make the state estimation more reliable, we introduce an additional information in the model without adding new states and without discretizing the considered measures. Thus, we associate to the state transition probabilities also a continuous metric given through the mean and the variance of some significant sensor measurements suitable to be kept under continuous form, such as odometric measurements, showing that also such unreliable data can supply a great deal of information to the robot. The overall control system of the robot is structured as a two-levels layered architecture, where the low level implements several collision avoidance algorithms, while the upper level takes care of the navigation problem. In this paper, we concentrate on how to use POMDP models at the upper level.

  12. Stochastic model of agent interaction with opinion leaders

    NASA Astrophysics Data System (ADS)

    Ellero, Andrea; Fasano, Giovanni; Sorato, Annamaria

    2013-04-01

    We analyze the problem of agents' interactions in a given population. The purpose of this paper is twofold. Starting from a scheme proposed by Galam [Physica A0378-437110.1016/S0378-4371(02)01582-0 320, 571 (2003)], which is based on a majority rule to treat the individuals’ interactions, we first study some of its relevant properties. Then, we introduce special individuals, called opinion leaders, who play a key role in information spreading in several practical applications. Opinion leaders have the special feature of strongly interfering with the process based on the majority rule, speeding up the diffusion. We consider a model describing agents’ interactions, which encompasses Galam's proposal, where opinion leaders are included as special agents. Then we study its specific properties which significantly recast and extend some conclusions drawn for the models given by Galam and Ellero, Fasano, and Sorato [Physica A0378-437110.1016/j.physa.2009.06.002 388, 3901 (2009)]. Finally, we provide theoretical and numerical results concerning the dynamics of our model, showing that a small percentage of opinion leaders may both accelerate and/or even reverse the overall consensus among all the agents.

  13. A simple model of directional interactions for proteins.

    PubMed

    Li, Xiaofei; Gunton, J D; Chakrabarti, A

    2009-09-21

    We study a simple two patch model of globular protein solutions. The model consists of a hard sphere interaction, together with a weak isotropic attraction, decorated with stronger attractive patch-patch interactions. The isotropic and anisotropic attractions are modeled with square well potentials with an interaction range of 1.2sigma, where sigma is the hard sphere diameter. We have calculated its phase diagram and found a metastable fluid-fluid phase separation curve. We have also obtained the different stable crystal structures at various temperatures. The orientationally ordered, body-centered crystal (bcc-o) lattice is the crystal structure that has the lowest energy; it is stable at lower temperatures and moderate pressures. The orientationally ordered face-centered crystal (fcc) lattice has a higher energy and becomes stable with respect to bcc-o at high pressures and lower temperatures. Finally, at high temperatures when the entropy effect becomes important, the orientational order is lost and an orientationally disordered fcc lattice becomes stable.

  14. Space station crew safety: Human factors interaction model

    NASA Technical Reports Server (NTRS)

    Cohen, M. M.; Junge, M. K.

    1985-01-01

    A model of the various human factors issues and interactions that might affect crew safety is developed. The first step addressed systematically the central question: How is this space station different from all other spacecraft? A wide range of possible issue was identified and researched. Five major topics of human factors issues that interacted with crew safety resulted: Protocols, Critical Habitability, Work Related Issues, Crew Incapacitation and Personal Choice. Second, an interaction model was developed that would show some degree of cause and effect between objective environmental or operational conditions and the creation of potential safety hazards. The intermediary steps between these two extremes of causality were the effects on human performance and the results of degraded performance. The model contains three milestones: stressor, human performance (degraded) and safety hazard threshold. Between these milestones are two countermeasure intervention points. The first opportunity for intervention is the countermeasure against stress. If this countermeasure fails, performance degrades. The second opportunity for intervention is the countermeasure against error. If this second countermeasure fails, the threshold of a potential safety hazard may be crossed.

  15. Interactive data exploration and particle tracking for general circulation models

    NASA Technical Reports Server (NTRS)

    Rosenbaum, R. I.; Peskin, R. L.; Walther, S. S.; Zinn, H. P.

    1995-01-01

    The SCENE environment for interactive visualization of complex data sets is discussed. This environment is used to create tools for graphical exploration of atmospheric flow models. These tools may be extended by the user in a seamless manner, so that no programming is required. A module for accurately tracing field lines and particle trajectories in SCENE is presented. This is used to examine the flowfield qualitatively with streamlines and pathlines and to identify critical points in the velocity field. The paper also describes a visualization tool for general circulation models on which the primary features of the environment are demonstrated.

  16. Computational modeling of RNA 3D structures and interactions.

    PubMed

    Dawson, Wayne K; Bujnicki, Janusz M

    2016-04-01

    RNA molecules have key functions in cellular processes beyond being carriers of protein-coding information. These functions are often dependent on the ability to form complex three-dimensional (3D) structures. However, experimental determination of RNA 3D structures is difficult, which has prompted the development of computational methods for structure prediction from sequence. Recent progress in 3D structure modeling of RNA and emerging approaches for predicting RNA interactions with ions, ligands and proteins have been stimulated by successes in protein 3D structure modeling.

  17. Modeling of High-Energy Pulsed Laser Interactions with Coupons

    SciTech Connect

    Boley, C D; Rubenchik, A M

    2003-02-06

    We describe a computational model of laser-materials interactions in the regime accessed by the solid state heat capacity lasers (SSHCLs) built at LLNL. We show that its predictions compare quite favorably with coupon experiments by the 10 kW SSHCL at LLNL. The body of this paper describes the following topics, listed by section number: (2) model in quiescent air, (3) comparison with experiments in quiescent air, (4) effects of air flow, (5) comparison with experiments involving air flow, (6) importance of material properties, (7) advantage of pulsed lasers over CW lasers, and (8) conclusions and recommendations.

  18. An investigation of ab initio shell-model interactions derived by no-core shell model

    NASA Astrophysics Data System (ADS)

    Wang, XiaoBao; Dong, GuoXiang; Li, QingFeng; Shen, CaiWan; Yu, ShaoYing

    2016-09-01

    The microscopic shell-model effective interactions are mainly based on the many-body perturbation theory (MBPT), the first work of which can be traced to Brown and Kuo's first attempt in 1966, derived from the Hamada-Johnston nucleon-nucleon potential. However, the convergence of the MBPT is still unclear. On the other hand, ab initio theories, such as Green's function Monte Carlo (GFMC), no-core shell model (NCSM), and coupled-cluster theory with single and double excitations (CCSD), have made many progress in recent years. However, due to the increasing demanding of computing resources, these ab initio applications are usually limited to nuclei with mass up to A = 16. Recently, people have realized the ab initio construction of valence-space effective interactions, which is obtained through a second-time renormalization, or to be more exactly, projecting the full-manybody Hamiltonian into core, one-body, and two-body cluster parts. In this paper, we present the investigation of such ab initio shell-model interactions, by the recent derived sd-shell effective interactions based on effective J-matrix Inverse Scattering Potential (JISP) and chiral effective-field theory (EFT) through NCSM. In this work, we have seen the similarity between the ab initio shellmodel interactions and the interactions obtained by MBPT or by empirical fitting. Without the inclusion of three-body (3-bd) force, the ab initio shell-model interactions still share similar defects with the microscopic interactions by MBPT, i.e., T = 1 channel is more attractive while T = 0 channel is more repulsive than empirical interactions. The progress to include more many-body correlations and 3-bd force is still badly needed, to see whether such efforts of ab initio shell-model interactions can reach similar precision as the interactions fitted to experimental data.

  19. Molecular modelling of protein-protein/protein-solvent interactions

    NASA Astrophysics Data System (ADS)

    Luchko, Tyler

    The inner workings of individual cells are based on intricate networks of protein-protein interactions. However, each of these individual protein interactions requires a complex physical interaction between proteins and their aqueous environment at the atomic scale. In this thesis, molecular dynamics simulations are used in three theoretical studies to gain insight at the atomic scale about protein hydration, protein structure and tubulin-tubulin (protein-protein) interactions, as found in microtubules. Also presented, in a fourth project, is a molecular model of solvation coupled with the Amber molecular modelling package, to facilitate further studies without the need of explicitly modelled water. Basic properties of a minimally solvated protein were calculated through an extended study of myoglobin hydration with explicit solvent, directly investigating water and protein polarization. Results indicate a close correlation between polarization of both water and protein and the onset of protein function. The methodology of explicit solvent molecular dynamics was further used to study tubulin and microtubules. Extensive conformational sampling of the carboxy-terminal tails of 8-tubulin was performed via replica exchange molecular dynamics, allowing the characterisation of the flexibility, secondary structure and binding domains of the C-terminal tails through statistical analysis methods. Mechanical properties of tubulin and microtubules were calculated with adaptive biasing force molecular dynamics. The function of the M-loop in microtubule stability was demonstrated in these simulations. The flexibility of this loop allowed constant contacts between the protofilaments to be maintained during simulations while the smooth deformation provided a spring-like restoring force. Additionally, calculating the free energy profile between the straight and bent tubulin configurations was used to test the proposed conformational change in tubulin, thought to cause microtubule

  20. Modeling insurer-homeowner interactions in managing natural disaster risk.

    PubMed

    Kesete, Yohannes; Peng, Jiazhen; Gao, Yang; Shan, Xiaojun; Davidson, Rachel A; Nozick, Linda K; Kruse, Jamie

    2014-06-01

    The current system for managing natural disaster risk in the United States is problematic for both homeowners and insurers. Homeowners are often uninsured or underinsured against natural disaster losses, and typically do not invest in retrofits that can reduce losses. Insurers often do not want to insure against these losses, which are some of their biggest exposures and can cause an undesirably high chance of insolvency. There is a need to design an improved system that acknowledges the different perspectives of the stakeholders. In this article, we introduce a new modeling framework to help understand and manage the insurer's role in catastrophe risk management. The framework includes a new game-theoretic optimization model of insurer decisions that interacts with a utility-based homeowner decision model and is integrated with a regional catastrophe loss estimation model. Reinsurer and government roles are represented as bounds on the insurer-insured interactions. We demonstrate the model for a full-scale case study for hurricane risk to residential buildings in eastern North Carolina; present the results from the perspectives of all stakeholders-primary insurers, homeowners (insured and uninsured), and reinsurers; and examine the effect of key parameters on the results.

  1. Reduced order modeling of fluid/structure interaction.

    SciTech Connect

    Barone, Matthew Franklin; Kalashnikova, Irina; Segalman, Daniel Joseph; Brake, Matthew Robert

    2009-11-01

    This report describes work performed from October 2007 through September 2009 under the Sandia Laboratory Directed Research and Development project titled 'Reduced Order Modeling of Fluid/Structure Interaction.' This project addresses fundamental aspects of techniques for construction of predictive Reduced Order Models (ROMs). A ROM is defined as a model, derived from a sequence of high-fidelity simulations, that preserves the essential physics and predictive capability of the original simulations but at a much lower computational cost. Techniques are developed for construction of provably stable linear Galerkin projection ROMs for compressible fluid flow, including a method for enforcing boundary conditions that preserves numerical stability. A convergence proof and error estimates are given for this class of ROM, and the method is demonstrated on a series of model problems. A reduced order method, based on the method of quadratic components, for solving the von Karman nonlinear plate equations is developed and tested. This method is applied to the problem of nonlinear limit cycle oscillations encountered when the plate interacts with an adjacent supersonic flow. A stability-preserving method for coupling the linear fluid ROM with the structural dynamics model for the elastic plate is constructed and tested. Methods for constructing efficient ROMs for nonlinear fluid equations are developed and tested on a one-dimensional convection-diffusion-reaction equation. These methods are combined with a symmetrization approach to construct a ROM technique for application to the compressible Navier-Stokes equations.

  2. Phase transitions in simplified models with long-range interactions

    NASA Astrophysics Data System (ADS)

    Rocha Filho, T. M.; Amato, M. A.; Mello, B. A.; Figueiredo, A.

    2011-10-01

    We study the origin of phase transitions in several simplified models with long-range interactions. For the self-gravitating ring model, we are unable to observe a possible phase transition predicted by Nardini and Casetti [Phys. Rev. EPLEEE81539-375510.1103/PhysRevE.80.060103 80, 060103R (2009).] from an energy landscape analysis. Instead we observe a sharp, although without any nonanalyticity, change from a core-halo to a core-only configuration in the spatial distribution functions for low energies. By introducing a different class of solvable simplified models without any critical points in the potential energy we show that a behavior similar to the thermodynamics of the ring model is obtained, with a first-order phase transition from an almost homogeneous high-energy phase to a clustered phase and the same core-halo to core configuration transition at lower energies. We discuss the origin of these features for the simplified models and show that the first-order phase transition comes from the maximization of the entropy of the system as a function of energy and an order parameter, as previously discussed by Hahn and Kastner [Phys. Rev. EPLEEE81539-375510.1103/PhysRevE.72.056134 72, 056134 (2005); Eur. Phys. J. BEPJBFY1434-602810.1140/epjb/e2006-00100-7 50, 311 (2006)], which seems to be the main mechanism causing phase transitions in long-range interacting systems.

  3. Unsupervised learnable neuron model with nonlinear interaction on dendrites.

    PubMed

    Todo, Yuki; Tamura, Hiroki; Yamashita, Kazuya; Tang, Zheng

    2014-12-01

    Recent researches have provided strong circumstantial support to dendrites playing a key and possibly essential role in computations. In this paper, we propose an unsupervised learnable neuron model by including the nonlinear interactions between excitation and inhibition on dendrites. The model neuron self-adjusts its synaptic parameters, so that the synapse to dendrite, according to a generalized delta-rule-like algorithm. The model is used to simulate directionally selective cells by the unsupervised learning algorithm. In the simulations, we initialize the interaction and dendrite of the neuron randomly and use the generalized delta-rule-like unsupervised learning algorithm to learn the two-dimensional multi-directional selectivity problem without an external teacher's signals. Simulation results show that the directionally selective cells can be formed by unsupervised learning, acquiring the required number of dendritic branches, and if needed, enhanced and if not, eliminated. Further, the results show whether a synapse exists; if it exists, where and what type (excitatory or inhibitory) of synapse it is. This leads us to believe that the proposed neuron model may be considerably more powerful on computations than the McCulloch-Pitts model because theoretically a single neuron or a single layer of such neurons is capable of solving any complex problem. These may also lead to a completely new technique for analyzing the mechanisms and principles of neurons, dendrites, and synapses.

  4. Development of an interactive anatomical three-dimensional eye model.

    PubMed

    Allen, Lauren K; Bhattacharyya, Siddhartha; Wilson, Timothy D

    2015-01-01

    The discrete anatomy of the eye's intricate oculomotor system is conceptually difficult for novice students to grasp. This is problematic given that this group of muscles represents one of the most common sites of clinical intervention in the treatment of ocular motility disorders and other eye disorders. This project was designed to develop a digital, interactive, three-dimensional (3D) model of the muscles and cranial nerves of the oculomotor system. Development of the 3D model utilized data from the Visible Human Project (VHP) dataset that was refined using multiple forms of 3D software. The model was then paired with a virtual user interface in order to create a novel 3D learning tool for the human oculomotor system. Development of the virtual eye model was done while attempting to adhere to the principles of cognitive load theory (CLT) and the reduction of extraneous load in particular. The detailed approach, digital tools employed, and the CLT guidelines are described herein.

  5. Strongly Interacting Matter at Finite Chemical Potential: Hybrid Model Approach

    NASA Astrophysics Data System (ADS)

    Srivastava, P. K.; Singh, C. P.

    2013-06-01

    Search for a proper and realistic equation of state (EOS) for strongly interacting matter used in the study of the QCD phase diagram still appears as a challenging problem. Recently, we constructed a hybrid model description for the quark-gluon plasma (QGP) as well as hadron gas (HG) phases where we used an excluded volume model for HG and a thermodynamically consistent quasiparticle model for the QGP phase. The hybrid model suitably describes the recent lattice results of various thermodynamical as well as transport properties of the QCD matter at zero baryon chemical potential (μB). In this paper, we extend our investigations further in obtaining the properties of QCD matter at finite value of μB and compare our results with the most recent results of lattice QCD calculation.

  6. Estimation and Model Selection for Finite Mixtures of Latent Interaction Models

    ERIC Educational Resources Information Center

    Hsu, Jui-Chen

    2011-01-01

    Latent interaction models and mixture models have received considerable attention in social science research recently, but little is known about how to handle if unobserved population heterogeneity exists in the endogenous latent variables of the nonlinear structural equation models. The current study estimates a mixture of latent interaction…

  7. How to model the interaction of charged Janus particles

    NASA Astrophysics Data System (ADS)

    Hieronimus, Reint; Raschke, Simon; Heuer, Andreas

    2016-08-01

    We analyze the interaction of charged Janus particles including screening effects. The explicit interaction is mapped via a least square method on a variable number n of systematically generated tensors that reflect the angular dependence of the potential. For n = 2 we show that the interaction is equivalent to a model previously described by Erdmann, Kröger, and Hess (EKH). Interestingly, this mapping is for n = 2 not able to capture the subtleties of the interaction for small screening lengths. Rather, a larger number of tensors has to be used. We find that the characteristics of the Janus type interaction plays an important role for the aggregation behavior. We obtained cluster structures up to the size of 13 particles for n = 2 and 36 and screening lengths κ-1 = 0.1 and 1.0 via Monte Carlo simulations. The influence of the screening length is analyzed and the structures are compared to results for an electrostatic-type potential and for the multipole-expanded Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. We find that a dipole-like potential (EKH or dipole DLVO approximation) is not able to sufficiently reproduce the anisotropy effects of the potential. Instead, a higher order expansion has to be used to obtain cluster structures that are compatible with experimental observations. The resulting minimum-energy clusters are compared to those of sticky hard sphere systems. Janus particles with a short-range screened interaction resemble sticky hard sphere clusters for all considered particle numbers, whereas for long-range screening even very small clusters are structurally different.

  8. Phospholipid interactions in model membrane systems. II. Theory.

    PubMed Central

    Stigter, D; Mingins, J; Dill, K A

    1992-01-01

    We describe statistical thermodynamic theory for the lateral interactions among phospholipid head groups in monolayers and bilayers. Extensive monolayer experiments show that at low surface densities, PC head groups have strong lateral repulsions which increase considerably with temperature, whereas PE interactions are much weaker and have no significant temperature dependence (see the preceding paper). In previous work, we showed that the second virial coefficients for these interactions can be explained by: (a) steric repulsions among the head groups, and (b) a tilting of the P-N+ dipole of PC so that the N+ end enters the oil phase, to an extent that increases with temperature. It was also predicted that PE interactions should be weaker and less temperature dependent because the N+ terminal of the PE head-group is hydrophilic, hence, it is tilted into the water phase, so dipolar contributions among PE's are negligible due to the high dielectric constant of water. In the present work, we broaden the theory to treat phospholipid interactions up to higher lateral surface densities. We generalize the Hill interfacial virial expansion to account for dipoles and to include the third virial term. We show that to account for the large third virial coefficients for both PC and PE requires that the short range lateral attractions among the head groups also be taken into account. In addition, the third virial coefficient includes fluctuating head group dipoles, computed by Monte Carlo integration assuming pairwise additivity of the instantaneous pair potentials. We find that because the dipole fluctuations are correlated, the average triplet interactions do not equal the sum of the average dipole pair potentials. This is important for predicting, the magnitude and the independence of temperature of the third virial coefficients for PC. The consistency of the theory with data of both the second and the third virial coefficients extends the applicability of the head

  9. Agent Based Modeling of Human Gut Microbiome Interactions and Perturbations

    PubMed Central

    Shashkova, Tatiana; Popenko, Anna; Tyakht, Alexander; Peskov, Kirill; Kosinsky, Yuri; Bogolubsky, Lev; Raigorodskii, Andrei; Ischenko, Dmitry; Alexeev, Dmitry; Govorun, Vadim

    2016-01-01

    Background Intestinal microbiota plays an important role in the human health. It is involved in the digestion and protects the host against external pathogens. Examination of the intestinal microbiome interactions is required for understanding of the community influence on host health. Studies of the microbiome can provide insight on methods of improving health, including specific clinical procedures for individual microbial community composition modification and microbiota correction by colonizing with new bacterial species or dietary changes. Methodology/Principal Findings In this work we report an agent-based model of interactions between two bacterial species and between species and the gut. The model is based on reactions describing bacterial fermentation of polysaccharides to acetate and propionate and fermentation of acetate to butyrate. Antibiotic treatment was chosen as disturbance factor and used to investigate stability of the system. System recovery after antibiotic treatment was analyzed as dependence on quantity of feedback interactions inside the community, therapy duration and amount of antibiotics. Bacterial species are known to mutate and acquire resistance to the antibiotics. The ability to mutate was considered to be a stochastic process, under this suggestion ratio of sensitive to resistant bacteria was calculated during antibiotic therapy and recovery. Conclusion/Significance The model confirms a hypothesis of feedbacks mechanisms necessity for providing functionality and stability of the system after disturbance. High fraction of bacterial community was shown to mutate during antibiotic treatment, though sensitive strains could become dominating after recovery. The recovery of sensitive strains is explained by fitness cost of the resistance. The model demonstrates not only quantitative dynamics of bacterial species, but also gives an ability to observe the emergent spatial structure and its alteration, depending on various feedback mechanisms

  10. Galaxies and Genes: How to Model Interacting Galaxies

    NASA Astrophysics Data System (ADS)

    Harfst, Stefan; Gerds, Christoph; Theis, Christian

    The observed features of interacting galaxies (e.g. tidal tails) provide a lot of information on the dynamics of such a system. Dark matter halos, for example, play an important rôle for the dynamical evolution of galaxies so that they should obviously have perceptible effects on the interaction. Unfortunately, the problem of modeling interacting galaxies from observational data suffers from an extended parameter space. Recently it has been shown that a Genetic Algorithm (GA) can be applied to this problem (Wahde 1998; Theis 1999). The general idea of a GA is to mimic natural evolution: A population of individuals which correspond to single points in parameter space (i.e. single N-body simulations) is evolved according to the principle of ``survival of the fittest''. The fitness is calculated by a comparison of observed intensities with the numerical model. New populations are created by ``sexual reproduction'' whereas individuals with a higher fitness reproduce themselves more often. This breeding process is repeated until a sufficient fit is achieved. Until now the GA has been applied to a chosen reference model (i.e. a preferred set of parameters) as in the case of NGC 4449 (Theis 1999). An automatic procedure for the selection of a suitable set of parameters on the basis of observational data is highly desirable. A first step in order to achieve this goal is an ``idealized'' observation which can be computed from a self-consistent N-body simulation. By this not only the parameters of the interaction are in control but one can also adjust the quality of the observational data allowing to check the general applicability of the GA to observational data.

  11. PREFACE: Singular interactions in quantum mechanics: solvable models

    NASA Astrophysics Data System (ADS)

    Dell'Antonio, Gianfausto; Exner, Pavel; Geyler, Vladimir

    2005-06-01

    This issue comprises two dozen research papers which are all in one sense or another devoted to models in which the interaction is singular and sharply localized; a typical example is a quantum particle interacting with a family of δ-type potentials. Such an idealization usually makes analysis of their properties considerably easier, sometimes allowing us to reduce it to a simple algebraic problem—this is why one speaks about solvable models. The subject can be traced back to the early days of quantum mechanics; however, the progress in this field was slow and uneven until the 1960s, mostly because singular interactions are often difficult to deal with mathematically and intuitive arguments do not work. After overcoming the initial difficulties the `classical' theory of point interactions was developed, and finally summarized in 1988 in a monograph by Albeverio, Gesztesy, Høegh-Krohn, and Holden, which you will find quoted in numerous places within this issue. A reliable way to judge theories is to observe the progress they make within one or two decades. In this case there is no doubt that the field has witnessed a continuous development and covered areas which nobody had thought of when the subject first emerged. The reader may see it in the second edition of the aforementioned book which was published by AMS Chelsea only recently and contained a brief survey of these new achievements. It is no coincidence that this topical issue appears at the same time; it has been conceived as its counterpart and a forum at which fresh results in the field can demonstrated. Let us briefly survey the contents of the issue. While the papers included have in common the basic subject, they represent a broad spectrum philosophically as well as technically, and any attempt to classify them is somewhat futile. Nevertheless, we will divide them into a few groups. The first comprises contributions directly related to the usual point-interaction ideology. M Correggi and one of the

  12. The Development in modeling Tibetan Plateau Land/Climate Interaction

    NASA Astrophysics Data System (ADS)

    Xue, Yongkang; Liu, Ye; li, qian; Maheswor Shrestha, Maheswor; Ma, Hsi-Yen; Cox, Peter; Sun, shufen; Koike, Toshio

    2015-04-01

    Tibetan Plateau (TP) plays an important role in influencing the continental and planetary scale climate, including East Asian and South Asian monsoon, circulation and precipitation over West Pacific and Indian Oceans. The numerical study has identified TP as the area with strongest land/atmosphere interactions over the midlatitude land. The land degradation there has also affected the monsoon precipitation in TP along the monsoon pathway. The water cycle there affects water sources for major Asian river systems, which include the Tarim, Amu Darya, Indus, Ganges, Brahmaputra, Irrawaddy, Salween, Mekong, Yellow, and Yangtze Rivers. Despite the importance of TP land process in the climate system, the TP land surface processes are poorly modeled due to lack of data available for model validation. To better understand, simulate, and project the role of Tibetan Plateau land surface processes, better parameterization of the Tibetan Land surface processes have been developed and evaluated. The recently available field measurement there and satellite observation have greatly helped this development. This paper presents these new developments and preliminary results using the newly developed biophysical/dynamic vegetation model, frozen soil model, and glacier model. In recent CMIP5 simulation, the CMIP5 models with dynamic vegetation model show poor performance in simulating the TP vegetation and climate. To better simulate the TP vegetation condition and its interaction with climate, we have developed biophysical/dynamic vegetation model, the Simplified Simple Biosphere Model version 4/Top-down Representation of Interactive Foliage and Flora Including Dynamics Model (SSiB4/TRIFFID), based on water, carbon, and energy balance. The simulated vegetation variables are updates, driven by carbon assimilation, allocation, and accumulation, as well as competition between plant functional types. The model has been validated with the station data, including those measured over the TP

  13. Exploring the Earth System through online interactive models

    NASA Astrophysics Data System (ADS)

    Coogan, L. A.

    2013-12-01

    Upper level Earth Science students commonly have a strong background of mathematical training from Math courses, however their ability to use mathematical models to solve Earth Science problems is commonly limited. Their difficulty comes, in part, because of the nature of the subject matter. There is a large body of background ';conceptual' and ';observational' understanding and knowledge required in the Earth Sciences before in-depth quantification becomes useful. For example, it is difficult to answer questions about geological processes until you can identify minerals and rocks and understand the general geodynamic implications of their associations. However, science is fundamentally quantitative. To become scientists students have to translate their conceptual understanding into quantifiable models. Thus, it is desirable for students to become comfortable with using mathematical models to test hypotheses. With the aim of helping to bridging the gap between conceptual understanding and quantification I have started to build an interactive teaching website based around quantitative models of Earth System processes. The site is aimed at upper-level undergraduate students and spans a range of topics that will continue to grow as time allows. The mathematical models are all built for the students, allowing them to spend their time thinking about how the ';model world' changes in response to their manipulation of the input variables. The web site is divided into broad topics or chapters (Background, Solid Earth, Ocean and Atmosphere, Earth history) and within each chapter there are different subtopic (e.g. Solid Earth: Core, Mantle, Crust) and in each of these individual webpages. Each webpage, or topic, starts with an introduction to the topic, followed by an interactive model that the students can use sliders to control the input to and watch how the results change. This interaction between student and model is guided by a series of multiple choice questions that

  14. Freed by interaction kinetic states in the Harper model

    NASA Astrophysics Data System (ADS)

    Frahm, Klaus M.; Shepelyansky, Dima L.

    2015-12-01

    We study the problem of two interacting particles in a one-dimensional quasiperiodic lattice of the Harper model. We show that a short or long range interaction between particles leads to emergence of delocalized pairs in the non-interacting localized phase. The properties of these freed by interaction kinetic states (FIKS) are analyzed numerically including the advanced Arnoldi method. We find that the number of sites populated by FIKS pairs grows algebraically with the system size with the maximal exponent b = 1, up to a largest lattice size N = 10 946 reached in our numerical simulations, thus corresponding to a complete delocalization of pairs. For delocalized FIKS pairs the spectral properties of such quasiperiodic operators represent a deep mathematical problem. We argue that FIKS pairs can be detected in the framework of recent cold atom experiments [M. Schreiber et al., Science 349, 842 (2015)] by a simple setup modification. We also discuss possible implications of FIKS pairs for electron transport in the regime of charge-density wave and high T c superconductivity.

  15. A conservative interface-interaction model with insoluble surfactant

    NASA Astrophysics Data System (ADS)

    Schranner, Felix S.; Adams, Nikolaus A.

    2016-12-01

    In this paper we extend the conservative interface-interaction method of Hu et al. (2006) [34], adapted for weakly-compressible flows by Luo et al. (2015) [37], to include the effects of viscous, capillary, and Marangoni stresses consistently as momentum-exchange terms at the sharp interface. The interface-interaction method is coupled with insoluble surfactant transport which employs the underlying sharp-interface representation. Unlike previous methods, we thus achieve discrete global conservation in terms of interface interactions and a consistently sharp interface representation. The interface is reconstructed locally, and a sub-cell correction of the interface curvature improves the evaluation of capillary stresses and surfactant diffusion in particular for marginal mesh resolutions. For a range of numerical test cases we demonstrate accuracy and robustness of the method. In particular, we show that the method is at least as accurate as previous diffuse-interface models while exhibiting throughout the considered test cases improved computational efficiency. We believe that the method is attractive for high-resolution level-set interface-tracking simulations as it straightforwardly incorporates the effects of variable surface tension into the underlying conservative interface-interaction approach.

  16. Periodic Striped Ground States in Ising Models with Competing Interactions

    NASA Astrophysics Data System (ADS)

    Giuliani, Alessandro; Seiringer, Robert

    2016-11-01

    We consider Ising models in two and three dimensions, with short range ferromagnetic and long range, power-law decaying, antiferromagnetic interactions. We let J be the ratio between the strength of the ferromagnetic to antiferromagnetic interactions. The competition between these two kinds of interactions induces the system to form domains of minus spins in a background of plus spins, or vice versa. If the decay exponent p of the long range interaction is larger than d + 1, with d the space dimension, this happens for all values of J smaller than a critical value J c ( p), beyond which the ground state is homogeneous. In this paper, we give a characterization of the infinite volume ground states of the system, for p > 2 d and J in a left neighborhood of J c ( p). In particular, we prove that the quasi-one-dimensional states consisting of infinite stripes ( d = 2) or slabs ( d = 3), all of the same optimal width and orientation, and alternating magnetization, are infinite volume ground states. Our proof is based on localization bounds combined with reflection positivity.

  17. A new interacting two-fluid model and its consequences

    NASA Astrophysics Data System (ADS)

    Sharov, G. S.; Bhattacharya, S.; Pan, S.; Nunes, R. C.; Chakraborty, S.

    2017-04-01

    In the background of a homogeneous and isotropic space-time with zero spatial curvature, we consider interacting scenarios between two barotropic fluids, one is the pressureless dark matter and the other one is dark energy (DE), in which the equation of state (EoS) in DE is either constant or time-dependent. In particular, for constant EoS in DE, we show that the evolution equations for both fluids can be analytically solved. For all these scenarios, the model parameters have been constrained using the current astronomical observations from Type Ia supernovae, Hubble parameter measurements and baryon acoustic oscillation distance measurements. Our analysis shows that both for constant and variable EoS in DE, a very small but non-zero interaction in the dark sector is favoured while the EoS in DE can predict a slight phantom nature, i.e. the EoS in DE can cross the phantom divide line '-1'. On the other hand, although the models with variable EoS describe the observations better, the Akaike Information Criterion supports models with minimal number of parameters. However, it is found that all the models are very close to the Λ cold dark matter cosmology.

  18. Coevolving complex networks in the model of social interactions

    NASA Astrophysics Data System (ADS)

    Raducha, Tomasz; Gubiec, Tomasz

    2017-04-01

    We analyze Axelrod's model of social interactions on coevolving complex networks. We introduce four extensions with different mechanisms of edge rewiring. The models are intended to catch two kinds of interactions-preferential attachment, which can be observed in scientists or actors collaborations, and local rewiring, which can be observed in friendship formation in everyday relations. Numerical simulations show that proposed dynamics can lead to the power-law distribution of nodes' degree and high value of the clustering coefficient, while still retaining the small-world effect in three models. All models are characterized by two phase transitions of a different nature. In case of local rewiring we obtain order-disorder discontinuous phase transition even in the thermodynamic limit, while in case of long-distance switching discontinuity disappears in the thermodynamic limit, leaving one continuous phase transition. In addition, we discover a new and universal characteristic of the second transition point-an abrupt increase of the clustering coefficient, due to formation of many small complete subgraphs inside the network.

  19. Modeling of Propagation of Interacting Cracks Under Hydraulic Pressure Gradient

    SciTech Connect

    Huang, Hai; Mattson, Earl Douglas; Podgorney, Robert Karl

    2015-04-01

    A robust and reliable numerical model for fracture initiation and propagation, which includes the interactions among propagating fractures and the coupling between deformation, fracturing and fluid flow in fracture apertures and in the permeable rock matrix, would be an important tool for developing a better understanding of fracturing behaviors of crystalline brittle rocks driven by thermal and (or) hydraulic pressure gradients. In this paper, we present a physics-based hydraulic fracturing simulator based on coupling a quasi-static discrete element model (DEM) for deformation and fracturing with conjugate lattice network flow model for fluid flow in both fractures and porous matrix. Fracturing is represented explicitly by removing broken bonds from the network to represent microcracks. Initiation of new microfractures and growth and coalescence of the microcracks leads to the formation of macroscopic fractures when external and/or internal loads are applied. The coupled DEM-network flow model reproduces realistic growth pattern of hydraulic fractures. In particular, simulation results of perforated horizontal wellbore clearly demonstrate that elastic interactions among multiple propagating fractures, fluid viscosity, strong coupling between fluid pressure fluctuations within fractures and fracturing, and lower length scale heterogeneities, collectively lead to complicated fracturing patterns.

  20. Sculpting Mountains: Interactive Terrain Modeling Based on Subsurface Geology.

    PubMed

    Cordonnier, Guillaume; Cani, Marie-Paule; Benes, Bedrich; Braun, Jean; Galin, Eric

    2017-03-29

    Most mountain ranges are formed by the compression and folding of colliding tectonic plates. Subduction of one plate causes large-scale asymmetry while their layered composition (or stratigraphy) explains the multi-scale folded strata observed on real terrains. We introduce a novel interactive modeling technique to generate visually plausible, large scale terrains that capture these phenomena. Our method draws on both geological knowledge for consistency and on sculpting systems for user interaction. The user is provided hands-on control on the shape and motion of tectonic plates, represented using a new geologically-inspired model for the Earth crust. The model captures their volume preserving and complex folding behaviors under collision, causing mountains to grow. It generates a volumetric uplift map representing the growth rate of subsurface layers. Erosion and uplift movement are jointly simulated to generate the terrain. The stratigraphy allows us to render folded strata on eroded cliffs. We validated the usability of our sculpting interface through a user study, and compare the visual consistency of the earth crust model with geological simulation results and real terrains.

  1. Convergent series for lattice models with polynomial interactions

    NASA Astrophysics Data System (ADS)

    Ivanov, Aleksandr S.; Sazonov, Vasily K.

    2017-01-01

    The standard perturbative weak-coupling expansions in lattice models are asymptotic. The reason for this is hidden in the incorrect interchange of the summation and integration. However, substituting the Gaussian initial approximation of the perturbative expansions by a certain interacting model or regularizing original lattice integrals, one can construct desired convergent series. In this paper we develop methods, which are based on the joint and separate utilization of the regularization and new initial approximation. We prove, that the convergent series exist and can be expressed as re-summed standard perturbation theory for any model on the finite lattice with the polynomial interaction of even degree. We discuss properties of such series and study their applicability to practical computations on the example of the lattice ϕ4-model. We calculate <ϕn2 > expectation value using the convergent series, the comparison of the results with the Borel re-summation and Monte Carlo simulations shows a good agreement between all these methods.

  2. Modeling the interactions between pathogenic bacteria, bacteriophage and immune response

    NASA Astrophysics Data System (ADS)

    Leung, Chung Yin (Joey); Weitz, Joshua S.

    The prevalence of antibiotic-resistant strains of pathogenic bacteria has led to renewed interest in the use of bacteriophage (phage), or virus that infects bacteria, as a therapeutic agent against bacterial infections. However, little is known about the theoretical mechanism by which phage therapy may work. In particular, interactions between the bacteria, the phage and the host immune response crucially influences the outcome of the therapy. Few models of phage therapy have incorporated all these three components, and existing models suffer from unrealistic assumptions such as unbounded growth of the immune response. We propose a model of phage therapy with an emphasis on nonlinear feedback arising from interactions with bacteria and the immune response. Our model shows a synergistic effect between the phage and the immune response which underlies a possible mechanism for phage to catalyze the elimination of bacteria even when neither the immune response nor phage could do so alone. We study the significance of this effect for different parameters of infection and immune response, and discuss its implications for phage therapy.

  3. A multi-interacting-agent model for financial markets

    NASA Astrophysics Data System (ADS)

    Queirós, Sílvio M. Duarte; Curado, E. M. F.; Nobre, F. D.

    2007-02-01

    Microscopic models, which resemble random magnetic systems, have been used recently in the literature for the description of financial markets. In the present work, a model with many interacting agents, similar to an Ising random magnet with infinite-range interactions, is investigated. The introduction of a local-field term, depending on the absolute value of a magnetization-like parameter-which measures the volatility of a financial market-leads to a significant improvement with respect to previously studied models in the literature. By investigating the return time series, we show that several features, characteristic of real financial markets, are better reproduced by the present model. In particular, within this approach one is able to provide a proper behavior for the following properties: (i) the power-law tails and the nonzero skewness of the probability distribution of returns; (ii) the exponential decay of the two-time autocorrelation function of returns, typical of high-frequency financial data; (iii) the so-called “leverage effect”, which corresponds to a negative correlation between past returns and future volatility.

  4. RANS Modeling of Benchmark Shockwave / Boundary Layer Interaction Experiments

    NASA Technical Reports Server (NTRS)

    Georgiadis, Nick; Vyas, Manan; Yoder, Dennis

    2010-01-01

    This presentation summarizes the computations of a set of shock wave / turbulent boundary layer interaction (SWTBLI) test cases using the Wind-US code, as part of the 2010 American Institute of Aeronautics and Astronautics (AIAA) shock / boundary layer interaction workshop. The experiments involve supersonic flows in wind tunnels with a shock generator that directs an oblique shock wave toward the boundary layer along one of the walls of the wind tunnel. The Wind-US calculations utilized structured grid computations performed in Reynolds-averaged Navier-Stokes mode. Three turbulence models were investigated: the Spalart-Allmaras one-equation model, the Menter Shear Stress Transport wavenumber-angular frequency two-equation model, and an explicit algebraic stress wavenumber-angular frequency formulation. Effects of grid resolution and upwinding scheme were also considered. The results from the CFD calculations are compared to particle image velocimetry (PIV) data from the experiments. As expected, turbulence model effects dominated the accuracy of the solutions with upwinding scheme selection indicating minimal effects.!

  5. Reduced quasilinear models for energetic particles interaction with Alfvenic eigenmodes

    NASA Astrophysics Data System (ADS)

    Ghantous, Katy

    The Line Broadened Quasilinear (LBQ) and the 1.5D reduced models are able to predict the effect of Alfvenic eigenmodes' interaction with energetic particles in burning plasmas. This interaction can result in energetic-particle losses that can damage the first wall, deteriorate the plasma performance, and even prevent ignition. The 1.5D model assumes a broad spectrum of overlapping modes and, based on analytic expressions for the growth and damping rates, calculates the pressure profiles that the energetic particles relax to upon interacting with the modes. 1.5D is validated with DIII-D experiments and predicted neutron losses consistent with observation. The model is employed to predict alpha-particle fusion-product losses in a large-scale operational parameter-space for burning plasmas. The LBQ model captures the interaction both in the regime of isolated modes as well as in the conventional regime of overlapping modes. Rules were established that allow quasilinear equations to replicate the expected steady-state saturation levels of isolated modes. The fitting formula is improved and the model is benchmarked with a Vlasov code, BOT. The saturation levels are accurately predicted and the mode evolution is well-replicated in the case of steady-state evolution where the collisions are high enough that coherent structures do not form. When the collisionality is low, oscillatory behavior can occur. LBQ can also exhibit non-steady behavior, but the onset of oscillations occurs for much higher collisional rates in BOT than in LBQ. For certain parameters of low collisionality, hole-clump creation and frequency chirping can occur which are not captured by the LBQ model. Also, there are cases of non-steady evolution without chirping which is possible for LBQ to study. However the results are inconclusive since the periods and amplitudes of the oscillations in the mode evolution are not well-replicated. If multiple modes exist, they can grow to the point of overlap which

  6. A Human View Model for Socio-Technical Interactions

    NASA Technical Reports Server (NTRS)

    Handley, Holly A.; Tolk, Andreas

    2012-01-01

    The Human View was developed as an additional architectural viewpoint to focus on the human part of a system. The Human View can be used to collect and organize data in order to understand how human operators interact and impact the other elements of a system. This framework can also be used to develop a model to describe how humans interact with each other in network enabled systems. These socio-technical interactions form the foundation of the emerging area of Human Interoperability. Human Interoperability strives to understand the relationships required between human operators that impact collaboration across networked environments, including the effect of belonging to different organizations. By applying organizational relationship concepts from network theory to the Human View elements, and aligning these relationships with a model developed to identify layers of coalition interoperability, the conditions for different levels for Human Interoperability for network enabled systems can be identified. These requirements can then be captured in the Human View products to improve the overall network enabled system.

  7. Fermented foods, neuroticism, and social anxiety: An interaction model.

    PubMed

    Hilimire, Matthew R; DeVylder, Jordan E; Forestell, Catherine A

    2015-08-15

    Animal models and clinical trials in humans suggest that probiotics can have an anxiolytic effect. However, no studies have examined the relationship between probiotics and social anxiety. Here we employ a cross-sectional approach to determine whether consumption of fermented foods likely to contain probiotics interacts with neuroticism to predict social anxiety symptoms. A sample of young adults (N=710, 445 female) completed self-report measures of fermented food consumption, neuroticism, and social anxiety. An interaction model, controlling for demographics, general consumption of healthful foods, and exercise frequency, showed that exercise frequency, neuroticism, and fermented food consumption significantly and independently predicted social anxiety. Moreover, fermented food consumption also interacted with neuroticism in predicting social anxiety. Specifically, for those high in neuroticism, higher frequency of fermented food consumption was associated with fewer symptoms of social anxiety. Taken together with previous studies, the results suggest that fermented foods that contain probiotics may have a protective effect against social anxiety symptoms for those at higher genetic risk, as indexed by trait neuroticism. While additional research is necessary to determine the direction of causality, these results suggest that consumption of fermented foods that contain probiotics may serve as a low-risk intervention for reducing social anxiety.

  8. Laser tissue interaction in the porcine otic capsule tissue model

    NASA Astrophysics Data System (ADS)

    Wong, Brian J.; Lee, Jon P.; Berns, Michael W.; White, Joel M.; Neev, Joseph

    1996-01-01

    The absence of a hard tissue model reflecting the properties of the inner and middle ear has made it difficult to draw consistent conclusions on the many experimental laser studies in ear surgery. Porcine otic capsule tissue has been studied by our group extensively in a wide variety of laser-tissue interaction studies and is an economically attractive and simple to use hard tissue source. Porcine otic capsule was harvested from the temporal bone of freshly sacrificed domestic pigs via a craniotomy approach. The technique when performed with power instruments takes less than 5 minutes and the entire otic capsule bone is removed intact as the suture line is not fused to the remaining petrous apex. The tissue specimen contains a vestibule, cochlea, oval and round windows, and internal auditory canals which can be used as an intact middle ear/inner ear system. The tissue can also be micromachined into thin slabs of bone varying for 100 - 1000 micrometers in thickness. In order to quantify more precisely the laser-tissue interactions in otic capsule, optical properties (absorption and scattering) and physical properties were determined (acoustic impedance). The tissue has been used in a wide variety of basic studies investigating the laser-tissue interactions with argon, KTP, (Nd:YAG), carbon dioxide, Ho:YAG, Er:YAG, and XeCl lasers. Porcine otic capsule is an ideal tissue on which standardized test can be performed to compare the relative effects of various laser in otosurgical models.

  9. Modelling the interaction between flooding events and economic growth

    NASA Astrophysics Data System (ADS)

    Grames, Johanna; Grass, Dieter; Prskawetz, Alexia; Blöschl, Günther

    2015-04-01

    Socio-hydrology describes the interaction between the socio-economy, water and population dynamics. Recent models analyze the interplay of community risk-coping culture, flooding damage and economic growth (Di Baldassarre, 2013, Viglione, 2014). These models descriptively explain the feedbacks between socio-economic development and natural disasters like floods. Contrary to these descriptive models, our approach develops an optimization model, where the intertemporal decision of an economic agent interacts with the hydrological system. This is the first economic growth model describing the interaction between the consumption and investment decisions of an economic agent and the occurrence of flooding events: Investments in defense capital can avoid floods even when the water level is high, but on the other hand such investment competes with investment in productive capital and hence may reduce the level of consumption. When floods occur, the flood damage therefore depends on the existing defense capital. The aim is to find an optimal tradeoff between investments in productive versus defense capital such as to optimize the stream of consumption in the long-term. We assume a non-autonomous exogenous periodic rainfall function (Yevjevich et.al. 1990, Zakaria 2001) which implies that the long-term equilibrium will be periodic . With our model we aim to derive mechanisms that allow consumption smoothing in the long term, and at the same time allow for optimal investment in flood defense to maximize economic output. We choose an aggregate welfare function that depends on the consumption level of the society as the objective function. I.e. we assume a social planer with perfect foresight that maximizes the aggregate welfare function. Within our model framework we can also study whether the path and level of defense capital (that protects people from floods) is related to the time preference rate of the social planner. Our model also allows to investigate how the frequency

  10. Kernel Method Based Human Model for Enhancing Interactive Evolutionary Optimization

    PubMed Central

    Zhao, Qiangfu; Liu, Yong

    2015-01-01

    A fitness landscape presents the relationship between individual and its reproductive success in evolutionary computation (EC). However, discrete and approximate landscape in an original search space may not support enough and accurate information for EC search, especially in interactive EC (IEC). The fitness landscape of human subjective evaluation in IEC is very difficult and impossible to model, even with a hypothesis of what its definition might be. In this paper, we propose a method to establish a human model in projected high dimensional search space by kernel classification for enhancing IEC search. Because bivalent logic is a simplest perceptual paradigm, the human model is established by considering this paradigm principle. In feature space, we design a linear classifier as a human model to obtain user preference knowledge, which cannot be supported linearly in original discrete search space. The human model is established by this method for predicting potential perceptual knowledge of human. With the human model, we design an evolution control method to enhance IEC search. From experimental evaluation results with a pseudo-IEC user, our proposed model and method can enhance IEC search significantly. PMID:25879050

  11. Kernel method based human model for enhancing interactive evolutionary optimization.

    PubMed

    Pei, Yan; Zhao, Qiangfu; Liu, Yong

    2015-01-01

    A fitness landscape presents the relationship between individual and its reproductive success in evolutionary computation (EC). However, discrete and approximate landscape in an original search space may not support enough and accurate information for EC search, especially in interactive EC (IEC). The fitness landscape of human subjective evaluation in IEC is very difficult and impossible to model, even with a hypothesis of what its definition might be. In this paper, we propose a method to establish a human model in projected high dimensional search space by kernel classification for enhancing IEC search. Because bivalent logic is a simplest perceptual paradigm, the human model is established by considering this paradigm principle. In feature space, we design a linear classifier as a human model to obtain user preference knowledge, which cannot be supported linearly in original discrete search space. The human model is established by this method for predicting potential perceptual knowledge of human. With the human model, we design an evolution control method to enhance IEC search. From experimental evaluation results with a pseudo-IEC user, our proposed model and method can enhance IEC search significantly.

  12. Nonlinear wave interaction and spin models in the magnetohydrodynamic regime

    NASA Astrophysics Data System (ADS)

    Brodin, G.; Lundin, J.; Zamanian, J.; Stefan, M.

    2011-08-01

    Here we consider the influence on the electron spin in the magnetohydrodynamic (MHD) regime. Recently developed models that include spin-velocity correlations are taken as the starting point. A theoretical argument is presented, suggesting that in the MHD regime a single-fluid electron model with spin correlations is equivalent to a model with spin-up and spin-down electrons constituting different fluids, but where the spin-velocity correlations are omitted. Three-wave interaction of two shear Alfvén waves and a compressional Alfvén wave is then taken as a model problem to evaluate the asserted equivalence. The theoretical argument turns out to be supported, because the predictions of the two models agree completely. Furthermore, the three-wave coupling coefficients obey the Manley-Rowe relations, which further support the soundness of the models and the validity of the assumptions made in the derivation. Finally, we point out that the proposed two-fluid model can be incorporated in standard particle-in-cell schemes with only minor modifications.

  13. On the earthquake predictability of fault interaction models

    PubMed Central

    Marzocchi, W; Melini, D

    2014-01-01

    Space-time clustering is the most striking departure of large earthquakes occurrence process from randomness. These clusters are usually described ex-post by a physics-based model in which earthquakes are triggered by Coulomb stress changes induced by other surrounding earthquakes. Notwithstanding the popularity of this kind of modeling, its ex-ante skill in terms of earthquake predictability gain is still unknown. Here we show that even in synthetic systems that are rooted on the physics of fault interaction using the Coulomb stress changes, such a kind of modeling often does not increase significantly earthquake predictability. Earthquake predictability of a fault may increase only when the Coulomb stress change induced by a nearby earthquake is much larger than the stress changes caused by earthquakes on other faults and by the intrinsic variability of the earthquake occurrence process. PMID:26074643

  14. Cloud-radiation interactions and their parameterization in climate models

    SciTech Connect

    1994-11-01

    This report contains papers from the International Workshop on Cloud-Radiation Interactions and Their Parameterization in Climate Models met on 18--20 October 1993 in Camp Springs, Maryland, USA. It was organized by the Joint Working Group on Clouds and Radiation of the International Association of Meteorology and Atmospheric Sciences. Recommendations were grouped into three broad areas: (1) general circulation models (GCMs), (2) satellite studies, and (3) process studies. Each of the panels developed recommendations on the. themes of the workshop. Explicitly or implicitly, each panel independently recommended observations of basic cloud microphysical properties (water content, phase, size) on the scales resolved by GCMs. Such observations are necessary to validate cloud parameterizations in GCMs, to use satellite data to infer radiative forcing in the atmosphere and at the earth`s surface, and to refine the process models which are used to develop advanced cloud parameterizations.

  15. On the earthquake predictability of fault interaction models

    NASA Astrophysics Data System (ADS)

    Marzocchi, W.; Melini, D.

    2014-12-01

    Space-time clustering is the most striking departure of large earthquakes occurrence process from randomness. These clusters are usually described ex-post by a physics-based model in which earthquakes are triggered by Coulomb stress changes induced by other surrounding earthquakes. Notwithstanding the popularity of this kind of modeling, its ex-ante skill in terms of earthquake predictability gain is still unknown. Here we show that even in synthetic systems that are rooted on the physics of fault interaction using the Coulomb stress changes, such a kind of modeling often does not increase significantly earthquake predictability. Earthquake predictability of a fault may increase only when the Coulomb stress change induced by a nearby earthquake is much larger than the stress changes caused by earthquakes on other faults and by the intrinsic variability of the earthquake occurrence process.

  16. Cloud-radiation interactions and their parameterization in climate models

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This report contains papers from the International Workshop on Cloud-Radiation Interactions and Their Parameterization in Climate Models met on 18-20 October 1993 in Camp Springs, Maryland, USA. It was organized by the Joint Working Group on Clouds and Radiation of the International Association of Meteorology and Atmospheric Sciences. Recommendations were grouped into three broad areas: (1) general circulation models (GCMs), (2) satellite studies, and (3) process studies. Each of the panels developed recommendations on the themes of the workshop. Explicitly or implicitly, each panel independently recommended observations of basic cloud microphysical properties (water content, phase, size) on the scales resolved by GCMs. Such observations are necessary to validate cloud parameterizations in GCMs, to use satellite data to infer radiative forcing in the atmosphere and at the earth's surface, and to refine the process models which are used to develop advanced cloud parameterizations.

  17. Interacting ghost dark energy models with variable G and Λ

    SciTech Connect

    Sadeghi, J.; Farahani, H.; Khurshudyan, M.; Movsisyan, A. E-mail: martiros.khurshudyan@nano.cnr.it E-mail: h.farahani@umz.ac.ir

    2013-12-01

    In this paper we consider several phenomenological models of variable Λ. Model of a flat Universe with variable Λ and G is accepted. It is well known, that varying G and Λ gives rise to modified field equations and modified conservation laws, which gives rise to many different manipulations and assumptions in literature. We will consider two component fluid, which parameters will enter to Λ. Interaction between fluids with energy densities ρ{sub 1} and ρ{sub 2} assumed as Q = 3Hb(ρ{sub 1}+ρ{sub 2}). We have numerical analyze of important cosmological parameters like EoS parameter of the composed fluid and deceleration parameter q of the model.

  18. Modeling of interactions of electromagnetic fields with human bodies

    NASA Astrophysics Data System (ADS)

    Caputa, Krzysztof

    Interactions of electromagnetic fields with the human body have been a subject of scientific interest and public concern. In recent years, issues in power line field effects and those of wireless telephones have been in the forefront of research. Engineering research compliments biological investigations by quantifying the induced fields in biological bodies due to exposure to external fields. The research presented in this thesis aims at providing reliable tools, and addressing some of the unresolved issues related to interactions with the human body of power line fields and fields produced by handheld wireless telephones. The research comprises two areas, namely development of versatile models of the human body and their visualisation, and verification and application of numerical codes to solve selected problems of interest. The models of the human body, which are based on the magnetic resonance scans of the body, are unique and differ considerably from other models currently available. With the aid of computer software developed, the models can be arranged to different postures, and medical devices can be accurately placed inside them. A previously developed code for modeling interactions of power line fields with biological bodies has been verified by rigorous, quantitative inter-laboratory comparison for two human body models. This code has been employed to model electromagnetic interference (EMI) of the magnetic field with implanted cardiac pacemakers. In this case, the correct placement and representation of the pacemaker leads are critical, as simplified computations have been shown to result in significant errors. In modeling interactions of wireless communication devices, the finite difference time domain technique (FDTD) has become a de facto standard. The previously developed code has been verified by comparison with the analytical solution for a conductive sphere. While previously researchers limited their verifications to principal axes of the sphere

  19. Vapor mediated droplet interactions - models and mechanisms (Part 2)

    NASA Astrophysics Data System (ADS)

    Benusiglio, Adrien; Cira, Nate; Prakash, Manu

    2014-11-01

    When deposited on clean glass a two-component binary mixture of propylene glycol and water is energetically inclined to spread, as both pure liquids do. Instead the mixture forms droplets stabilized by evaporation induced surface tension gradients, giving them unique properties such as negligible hysteresis. When two of these special droplets are deposited several radii apart they attract each other. The vapor from one droplet destabilizes the other, resulting in an attraction force which brings both droplets together. We present a flux-based model for droplet stabilization and a model which connects the vapor profile to net force. These simple models capture the static and dynamic experimental trends, and our fundamental understanding of these droplets and their interactions allowed us to build autonomous fluidic machines.

  20. Interactions of model biomolecules. Benchmark CC calculations within MOLCAS

    SciTech Connect

    Urban, Miroslav; Pitoňák, Michal; Neogrády, Pavel; Dedíková, Pavlína; Hobza, Pavel

    2015-01-22

    We present results using the OVOS approach (Optimized Virtual Orbitals Space) aimed at enhancing the effectiveness of the Coupled Cluster calculations. This approach allows to reduce the total computer time required for large-scale CCSD(T) calculations about ten times when the original full virtual space is reduced to about 50% of its original size without affecting the accuracy. The method is implemented in the MOLCAS computer program. When combined with the Cholesky decomposition of the two-electron integrals and suitable parallelization it allows calculations which were formerly prohibitively too demanding. We focused ourselves to accurate calculations of the hydrogen bonded and the stacking interactions of the model biomolecules. Interaction energies of the formaldehyde, formamide, benzene, and uracil dimers and the three-body contributions in the cytosine – guanine tetramer are presented. Other applications, as the electron affinity of the uracil affected by solvation are also shortly mentioned.

  1. Probabilistic Multi-Factor Interaction Model for Complex Material Behavior

    NASA Technical Reports Server (NTRS)

    Chamis, Christos C.; Abumeri, Galib H.

    2008-01-01

    The Multi-Factor Interaction Model (MFIM) is used to evaluate the divot weight (foam weight ejected) from the launch external tanks. The multi-factor has sufficient degrees of freedom to evaluate a large number of factors that may contribute to the divot ejection. It also accommodates all interactions by its product form. Each factor has an exponent that satisfies only two points the initial and final points. The exponent describes a monotonic path from the initial condition to the final. The exponent values are selected so that the described path makes sense in the absence of experimental data. In the present investigation, the data used was obtained by testing simulated specimens in launching conditions. Results show that the MFIM is an effective method of describing the divot weight ejected under the conditions investigated.

  2. Probabilistic Multi-Factor Interaction Model for Complex Material Behavior

    NASA Technical Reports Server (NTRS)

    Chamis, Christos C.; Abumeri, Galib H.

    2008-01-01

    The Multi-Factor Interaction Model (MFIM) is used to evaluate the divot weight (foam weight ejected) from the launch external tanks. The multi-factor has sufficient degrees of freedom to evaluate a large number of factors that may contribute to the divot ejection. It also accommodates all interactions by its product form. Each factor has an exponent that satisfies only two points, the initial and final points. The exponent describes a monotonic path from the initial condition to the final. The exponent values are selected so that the described path makes sense in the absence of experimental data. In the present investigation the data used was obtained by testing simulated specimens in launching conditions. Results show that the MFIM is an effective method of describing the divot weight ejected under the conditions investigated.

  3. Coarse-grained models for interacting, flapping swimmers

    NASA Astrophysics Data System (ADS)

    Oza, Anand; Ristroph, Leif; Shelley, Michael; Courant Institute Applied Math Lab Collaboration

    2016-11-01

    We present the results of a theoretical investigation into the dynamics of interacting flapping swimmers. Our study is motivated by ongoing experiments in the NYU Applied Math Lab, in which freely-translating, heaving airfoils interact hydrodynamically to choose their relative positions and velocities. We develop a discrete dynamical system in which flapping swimmers shed point vortices during each flapping cycle, which in turn exert forces on the swimmers. We present a framework for finding exact solutions to the evolution equations and for assessing their stability, giving physical insight into the preference for certain observed "schooling states". The model may be extended to arrays of flapping swimmers, and configurations in which the swimmers' flapping frequencies are incommensurate. Generally, our results indicate how hydrodynamics may mediate schooling and flocking behavior in biological contexts. A. Oza acknowledges the support of the NSF Mathematical Sciences Postdoctoral Fellowship.

  4. Interaction of multiple biomimetic antimicrobial polymers with model bacterial membranes

    SciTech Connect

    Baul, Upayan Vemparala, Satyavani; Kuroda, Kenichi

    2014-08-28

    Using atomistic molecular dynamics simulations, interaction of multiple synthetic random copolymers based on methacrylates on prototypical bacterial membranes is investigated. The simulations show that the cationic polymers form a micellar aggregate in water phase and the aggregate, when interacting with the bacterial membrane, induces clustering of oppositely charged anionic lipid molecules to form clusters and enhances ordering of lipid chains. The model bacterial membrane, consequently, develops lateral inhomogeneity in membrane thickness profile compared to polymer-free system. The individual polymers in the aggregate are released into the bacterial membrane in a phased manner and the simulations suggest that the most probable location of the partitioned polymers is near the 1-palmitoyl-2-oleoyl-phosphatidylglycerol (POPG) clusters. The partitioned polymers preferentially adopt facially amphiphilic conformations at lipid-water interface, despite lacking intrinsic secondary structures such as α-helix or β-sheet found in naturally occurring antimicrobial peptides.

  5. Interaction of multiple biomimetic antimicrobial polymers with model bacterial membranes

    NASA Astrophysics Data System (ADS)

    Baul, Upayan; Kuroda, Kenichi; Vemparala, Satyavani

    2014-08-01

    Using atomistic molecular dynamics simulations, interaction of multiple synthetic random copolymers based on methacrylates on prototypical bacterial membranes is investigated. The simulations show that the cationic polymers form a micellar aggregate in water phase and the aggregate, when interacting with the bacterial membrane, induces clustering of oppositely charged anionic lipid molecules to form clusters and enhances ordering of lipid chains. The model bacterial membrane, consequently, develops lateral inhomogeneity in membrane thickness profile compared to polymer-free system. The individual polymers in the aggregate are released into the bacterial membrane in a phased manner and the simulations suggest that the most probable location of the partitioned polymers is near the 1-palmitoyl-2-oleoyl-phosphatidylglycerol (POPG) clusters. The partitioned polymers preferentially adopt facially amphiphilic conformations at lipid-water interface, despite lacking intrinsic secondary structures such as α-helix or β-sheet found in naturally occurring antimicrobial peptides.

  6. Three-Dimensional Modeling of Air-Sea Interaction

    NASA Astrophysics Data System (ADS)

    Regis, J. L.; Slinn, D. N.

    2004-12-01

    Deep-water wave breaking is crucial in the transfer of heat, gases, and momentum between the ocean and the atmosphere. Observations of these events have provided qualitative support to this end, and yet accurate quantification of momentum transfer for strong winds and nonlinear waves has remained a challenge. In recent years, advances have been made in the development of numerous algorithms to capture and describe air-sea interaction. Most, however, are idealized and only capable of modeling fluid flow within the two-dimensional approximation. Thus, many important characteristics of the flow composition and breaking process are ignored, oversimplified, or remain unknown. We employ a three-dimensional, time-dependent, finite difference, volume of fluid model, including both the flow of air and water, entitled TRUCHAS, to address the issue of deep-water breaking waves. Our model utilizes the multidimensional piecewise linear interface calculation method to assess the volume fraction of each fluid material in every mesh cell. The model solves conservation equations for mass and momentum for multiple fluids within the domain and tracks the interfaces between them. A great many details of the flow development are available for analysis from the model output. These include wind and water velocities, pressure gradients in both the air and sea around a breaking wave, the development and evolution of wind-generated waves, and the corresponding transfer of momentum from the atmosphere to the ocean. Our results are correlated with laboratory experiments conducted at the University of Miami's Air-Sea Interaction Salt-water Tank that possesses both wind and wave generating capabilities. Preliminary model results show good qualitative agreement to laboratory data.

  7. Parametric Model for Astrophysical Proton-Proton Interactions and Applications

    SciTech Connect

    Karlsson, Niklas

    2007-01-01

    Observations of gamma-rays have been made from celestial sources such as active galaxies, gamma-ray bursts and supernova remnants as well as the Galactic ridge. The study of gamma rays can provide information about production mechanisms and cosmic-ray acceleration. In the high-energy regime, one of the dominant mechanisms for gamma-ray production is the decay of neutral pions produced in interactions of ultra-relativistic cosmic-ray nuclei and interstellar matter. Presented here is a parametric model for calculations of inclusive cross sections and transverse momentum distributions for secondary particles--gamma rays, e±, ve, $\\bar{v}$e, vμ and $\\bar{μ}$e--produced in proton-proton interactions. This parametric model is derived on the proton-proton interaction model proposed by Kamae et al.; it includes the diffraction dissociation process, Feynman-scaling violation and the logarithmically rising inelastic proton-proton cross section. To improve fidelity to experimental data for lower energies, two baryon resonance excitation processes were added; one representing the Δ(1232) and the other multiple resonances with masses around 1600 MeV/c2. The model predicts the power-law spectral index for all secondary particle to be about 0.05 lower in absolute value than that of the incident proton and their inclusive cross sections to be larger than those predicted by previous models based on the Feynman-scaling hypothesis. The applications of the presented model in astrophysics are plentiful. It has been implemented into the Galprop code to calculate the contribution due to pion decays in the Galactic plane. The model has also been used to estimate the cosmic-ray flux in the Large Magellanic Cloud based on HI, CO and gamma-ray observations. The transverse momentum distributions enable calculations when the proton distribution is anisotropic. It is shown that the gamma-ray spectrum and flux due to a

  8. Interactive model evaluation tool based on IPython notebook

    NASA Astrophysics Data System (ADS)

    Balemans, Sophie; Van Hoey, Stijn; Nopens, Ingmar; Seuntjes, Piet

    2015-04-01

    In hydrological modelling, some kind of parameter optimization is mostly performed. This can be the selection of a single best parameter set, a split in behavioural and non-behavioural parameter sets based on a selected threshold or a posterior parameter distribution derived with a formal Bayesian approach. The selection of the criterion to measure the goodness of fit (likelihood or any objective function) is an essential step in all of these methodologies and will affect the final selected parameter subset. Moreover, the discriminative power of the objective function is also dependent from the time period used. In practice, the optimization process is an iterative procedure. As such, in the course of the modelling process, an increasing amount of simulations is performed. However, the information carried by these simulation outputs is not always fully exploited. In this respect, we developed and present an interactive environment that enables the user to intuitively evaluate the model performance. The aim is to explore the parameter space graphically and to visualize the impact of the selected objective function on model behaviour. First, a set of model simulation results is loaded along with the corresponding parameter sets and a data set of the same variable as the model outcome (mostly discharge). The ranges of the loaded parameter sets define the parameter space. A selection of the two parameters visualised can be made by the user. Furthermore, an objective function and a time period of interest need to be selected. Based on this information, a two-dimensional parameter response surface is created, which actually just shows a scatter plot of the parameter combinations and assigns a color scale corresponding with the goodness of fit of each parameter combination. Finally, a slider is available to change the color mapping of the points. Actually, the slider provides a threshold to exclude non behaviour parameter sets and the color scale is only attributed to the

  9. GSSI, a general model for solute-solvent interactions. 1. Description of the model.

    PubMed

    Deanda, Felix; Smith, Karl M; Liu, Jie; Pearlman, Robert S

    2004-01-12

    A novel, semiempirical approach for the general treatment of solute-solvent interactions (GSSI) was developed to enable the prediction of solution-phase properties (e.g., free energies of desolvation, partition coefficients, and membrane permeabilities). The GSSI approach is based on the principle that all solution-phase processes can be modeled in terms of one or more gas-to-solution transfer processes. The free energy of each gas-to-solution transfer process is calculated as the sum of the free energy of cavity formation and the free energy of solute-solvent interaction. The solute's contributions to these free energies are modeled on the basis of various quantities computed from the solute's three-dimensional (3D) structure, whereas the solvent's contributions are modeled by empirically determined regression coefficients. More specifically, the free energy of cavity formation is modeled on the basis of the total solvent-accessible surface area of the solute. The enthalpy of solute-solvent interaction is modeled on the basis of intermolecular interaction potentials calculated at many uniformly distributed points on the solvent-accessible surface of the solute. The entropy of solute-solvent interaction is modeled on the basis of an effective number of rotatable bonds in the solute and by the regression coefficients characteristic of the solvent. The potential utility of the GSSI approach was demonstrated by modeling the free energy of gas-to-solution transfer for 111 solutes in water, 250 solutes in hexadecane, and 84 solutes in octanol.

  10. Fluid Structure Interaction Analysis on Sidewall Aneurysm Models

    NASA Astrophysics Data System (ADS)

    Hao, Qing

    2016-11-01

    Wall shear stress is considered as an important factor for cerebral aneurysm growth and rupture. The objective of present study is to evaluate wall shear stress in aneurysm sac and neck by a fluid-structure-interaction (FSI) model, which was developed and validated against the particle image velocimetry (PIV) data. In this FSI model, the flow characteristics in a straight tube with different asymmetric aneurysm sizes over a range of Reynolds numbers from 200 to 1600 were investigated. The FSI results agreed well with PIV data. It was found that at steady flow conditions, when Reynolds number above 700, one large recirculating vortex would be formed, occupying the entire aneurysm sac. The center of the vortex is located at region near to the distal neck. A pair of counter rotating vortices would however be formed at Reynolds number below 700. Wall shear stresses reached highest level at the distal neck of the aneurysmal sac. The vortex strength, in general, is stronger at higher Reynolds number. Fluid Structure Interaction Analysis on Sidewall Aneurysm Models.

  11. Determining Interactions in PSA models: Application to a Space PSA

    SciTech Connect

    C. Smith; E. Borgonovo

    2010-06-01

    This paper addresses use of an importance measure interaction study of a probabilistic risk analysis (PSA) performed for a hypothetical aerospace lunar mission. The PSA methods used in this study follow the general guidance provided in the NASA Probabilistic Risk Assessment Procedures Guide for NASA Managers and Practitioners. For the PSA portion, we used phased-based event tree and fault tree logic structures are used to model a lunar mission, including multiple phases (from launch to return to the Earth surface) and multiple critical systems. Details of the analysis results are not provided in this paper – instead specific basic events are denoted by number (e.g., the first event is 1, the second is 2, and so on). However, in the model, we used approximately 150 fault trees and over 800 basic events. Following analysis and truncation of cut sets, we were left with about 400 basic events to evaluate. We used this model to explore interactions between different basic events and systems. These sensitivity studies provide high-level insights into features of the PSA for the hypothetical lunar mission.

  12. An interactive flow model for projecting school enrolments

    NASA Astrophysics Data System (ADS)

    Gould, Edward

    1993-07-01

    Successful planning in educational administration is highly dependent on accurate student numbers. An interactive enrolment projection model is described which begins with pre-school age children to project the expected number of first grade entrants. These cohorts are then progressed through the school system. The model described can be implemented on a microcomputer and uses an interactive technique which enables human intervention in order to take full account of local knowledge in predicting the numbers in each year group. Control is maintained by allowing groups of schools to be amalgamated and then by applying to these larger groups the same techniques used to obtain the initial individual school enrolments. Adjustments to individual school enrolments are then possible following the reconciliation of larger group figures with known demographic statistics. This counteracts the effects of student mobility across wider areas and overcomes many of the problems associated with simple aggregation of individual school projections. The model provides a valuable planning tool when enrolment figures are needed for decision making.

  13. Modeling of Fluid-Membrane Interaction in Cellular Microinjection Process

    NASA Astrophysics Data System (ADS)

    Karzar-Jeddi, Mehdi; Diaz, Jhon; Olgac, Nejat; Fan, Tai-Hsi

    2009-11-01

    Cellular microinjection is a well-accepted method to deliver matters such as sperm, nucleus, or macromolecules into biological cells. To improve the success rate of in vitro fertilization and to establish the ideal operating conditions for a novel computer controlled rotationally oscillating intracytoplasmic sperm injection (ICSI) technology, we investigate the fluid-membrane interactions in the ICSI procedure. The procedure consists of anchoring the oocyte (a developing egg) using a holding pipette, penetrating oocyte's zona pellucida (the outer membrane) and the oolemma (the plasma or inner membrane) using an injection micropipette, and finally to deliver sperm into the oocyte for fertilization. To predict the large deformation of the oocyte membranes up to the piercing of the oolemma and the motion of fluids across both membranes, the dynamic fluid-pipette-membrane interactions are formulated by the coupled Stokes' equations and the continuum membrane model based on Helfrich's energy theory. A boundary integral model is developed to simulate the transient membrane deformation and the local membrane stress induced by the longitudinal motion of the injection pipette. The model captures the essential features of the membranes shown on optical images of ICSI experiments, and is capable of suggesting the optimal deformation level of the oolemma to start the rotational oscillations for piercing into the oolemma.

  14. Turbulence Modeling for Shock Wave/Turbulent Boundary Layer Interactions

    NASA Technical Reports Server (NTRS)

    Lillard, Randolph P.

    2011-01-01

    Accurate aerodynamic computational predictions are essential for the safety of space vehicles, but these computations are of limited accuracy when large pressure gradients are present in the flow. The goal of the current project is to improve the state of compressible turbulence modeling for high speed flows with shock wave / turbulent boundary layer interactions (SWTBLI). Emphasis will be placed on models that can accurately predict the separated region caused by the SWTBLI. These flows are classified as nonequilibrium boundary layers because of the very large and variable adverse pressure gradients caused by the shock waves. The lag model was designed to model these nonequilibrium flows by incorporating history effects. Standard one- and two-equation models (Spalart Allmaras and SST) and the lag model will be run and compared to a new lag model. This new model, the Reynolds stress tensor lag model (lagRST), will be assessed against multiple wind tunnel tests and correlations. The basis of the lag and lagRST models are to preserve the accuracy of the standard turbulence models in equilibrium turbulence, when the Reynolds stresses are linearly related to the mean strain rates, but create a lag between mean strain rate effects and turbulence when nonequilibrium effects become important, such as in large pressure gradients. The affect this lag has on the results for SWBLI and massively separated flows will be determined. These computations will be done with a modified version of the OVERFLOW code. This code solves the RANS equations on overset grids. It was used for this study for its ability to input very complex geometries into the flow solver, such as the Space Shuttle in the full stack configuration. The model was successfully implemented within two versions of the OVERFLOW code. Results show a substantial improvement over the baseline models for transonic separated flows. The results are mixed for the SWBLI assessed. Separation predictions are not as good as the

  15. Blood vessel modeling for interactive simulation of interventional neuroradiology procedures.

    PubMed

    Kerrien, E; Yureidini, A; Dequidt, J; Duriez, C; Anxionnat, R; Cotin, S

    2017-01-01

    Endovascular interventions can benefit from interactive simulation in their training phase but also during pre-operative and intra-operative phases if simulation scenarios are based on patient data. A key feature in this context is the ability to extract, from patient images, models of blood vessels that impede neither the realism nor the performance of simulation. This paper addresses both the segmentation and reconstruction of the vasculature from 3D Rotational Angiography data, and adapted to simulation: An original tracking algorithm is proposed to segment the vessel tree while filtering points extracted at the vessel surface in the vicinity of each point on the centerline; then an automatic procedure is described to reconstruct each local unstructured point set as a skeleton-based implicit surface (blobby model). The output of successively applying both algorithms is a new model of vasculature as a tree of local implicit models. The segmentation algorithm is compared with Multiple Hypothesis Testing (MHT) algorithm (Friman et al., 2010) on patient data, showing its greater ability to track blood vessels. The reconstruction algorithm is evaluated on both synthetic and patient data and demonstrate its ability to fit points with a subvoxel precision. Various tests are also reported where our model is used to simulate catheter navigation in interventional neuroradiology. An excellent realism, and much lower computational costs are reported when compared to triangular mesh surface models.

  16. A model of the interaction between mood and memory.

    PubMed

    Rolls, E T; Stringer, S M

    2001-05-01

    This paper investigates a neural network model of the interaction between mood and memory. The model has two attractor networks that represent the inferior temporal cortex (IT), which stores representations of visual stimuli, and the amygdala, the activity of which reflects the mood state. The two attractor networks are coupled by forward and backward projections. The model is however generic, and is relevant to understanding the interaction between different pairs of modules in the brain, particularly, as is the case with moods and memories, when there are fewer states represented in one module than in the other. During learning, a large number of patterns are presented to the IT, each paired with one of two mood states represented in the amygdala. The recurrent connections within each module, the forward connections from the memory module to the amygdala, and the backward connections from the amygdala to the memory module, are associatively modified. It is shown how the mood state in the amygdala can influence which memory patterns are recalled in the memory module. Further, it is shown that if there is an existing mood state in the amygdala, it can be difficult to change it even when a retrieval cue is presented to the memory module that is associated with a different mood state. It is also shown that the backprojections from the amygdala to the memory module must be relatively weak if memory retrieval in the memory module is not to be disrupted. The results are relevant to understanding the interaction between structures important in mood and emotion (such as the amygdala and orbitofrontal cortex) and other brain areas involved in storing objects and faces (such as the inferior temporal visual cortex) and memories (such as the hippocampus).

  17. Modeling shear band interaction in 1D torsion

    NASA Astrophysics Data System (ADS)

    Partom, Yehuda; Hanina, Erez

    2017-01-01

    When two shear bands are being formed at close distance from each other they interact, and further development of one of them may be quenched down. As a result there should be a minimum distance between shear bands. In the literature there are at least three analytical models for this minimum distance. Predictions of these models do not generally agree with each other and with test results. Recently we developed a 1D numerical scheme to predict the formation of shear bands in a torsion test of a thin walled pipe. We validated our code by reproducing results of the pioneering experiments of Marchand and Duffy, and then used it to investigate the mechanics of shear localization and shear band formation. We describe our shear band code in a separate publication, and here we use it only as a tool to investigate the interaction between two neighboring shear bands during the process of their formation. We trigger the formation of shear bands by specifying two perturbations of the initial strength. We vary the perturbations in terms of their amplitude and/or their width. Usually, the stronger perturbation triggers a faster developing shear band, which then prevails and quenches the development of the other shear band. We change the distance between the two shear bands and find, that up to a certain distance one of the shear bands becomes fully developed, and the other stays only partially developed. Beyond this distance the two shear bands are both fully developed. Finally, we check the influence of certain material and loading parameters on the interaction between the two shear bands, and compare the results to predictions of the analytical models from the literature.

  18. Current advancements and challenges in soil-root interactions modelling

    NASA Astrophysics Data System (ADS)

    Schnepf, Andrea; Huber, Katrin; Abesha, Betiglu; Meunier, Felicien; Leitner, Daniel; Roose, Tiina; Javaux, Mathieu; Vanderborght, Jan; Vereecken, Harry

    2015-04-01

    Roots change their surrounding soil chemically, physically and biologically. This includes changes in soil moisture and solute concentration, the exudation of organic substances into the rhizosphere, increased growth of soil microorganisms, or changes in soil structure. The fate of water and solutes in the root zone is highly determined by these root-soil interactions. Mathematical models of soil-root systems in combination with non-invasive techniques able to characterize root systems are a promising tool to understand and predict the behaviour of water and solutes in the root zone. With respect to different fields of applications, predictive mathematical models can contribute to the solution of optimal control problems in plant recourse efficiency. This may result in significant gains in productivity, efficiency and environmental sustainability in various land use activities. Major challenges include the coupling of model parameters of the relevant processes with the surrounding environment such as temperature, nutrient concentration or soil water content. A further challenge is the mathematical description of the different spatial and temporal scales involved. This includes in particular the branched structures formed by root systems or the external mycelium of mycorrhizal fungi. Here, reducing complexity as well as bridging between spatial scales is required. Furthermore, the combination of experimental and mathematical techniques may advance the field enormously. Here, the use of root system, soil and rhizosphere models is presented through a number of modelling case studies, including image based modelling of phosphate uptake by a root with hairs, model-based optimization of root architecture for phosphate uptake from soil, upscaling of rhizosphere models, modelling root growth in structured soil, and the effect of root hydraulic architecture on plant water uptake efficiency and drought resistance.

  19. Current Advancements and Challenges in Soil-Root Interactions Modelling

    NASA Astrophysics Data System (ADS)

    Schnepf, A.; Huber, K.; Abesha, B.; Meunier, F.; Leitner, D.; Roose, T.; Javaux, M.; Vanderborght, J.; Vereecken, H.

    2014-12-01

    Roots change their surrounding soil chemically, physically and biologically. This includes changes in soil moisture and solute concentration, the exudation of organic substances into the rhizosphere, increased growth of soil microorganisms, or changes in soil structure. The fate of water and solutes in the root zone is highly determined by these root-soil interactions. Mathematical models of soil-root systems in combination with non-invasive techniques able to characterize root systems are a promising tool to understand and predict the behaviour of water and solutes in the root zone. With respect to different fields of applications, predictive mathematical models can contribute to the solution of optimal control problems in plant recourse efficiency. This may result in significant gains in productivity, efficiency and environmental sustainability in various land use activities. Major challenges include the coupling of model parameters of the relevant processes with the surrounding environment such as temperature, nutrient concentration or soil water content. A further challenge is the mathematical description of the different spatial and temporal scales involved. This includes in particular the branched structures formed by root systems or the external mycelium of mycorrhizal fungi. Here, reducing complexity as well as bridging between spatial scales is required. Furthermore, the combination of experimental and mathematical techniques may advance the field enormously. Here, the use of root system, soil and rhizosphere models is presented through a number of modelling case studies, including image based modelling of phosphate uptake by a root with hairs, model-based optimization of root architecture for phosphate uptake from soil, upscaling of rhizosphere models, modelling root growth in structured soil, and the effect of root hydraulic architecture on plant water uptake efficiency and drought resistance.

  20. A mathematical model of stress generation in microtubule pair interactions

    NASA Astrophysics Data System (ADS)

    Fang, Fang; Betterton, Meredith; Shelley, Michael

    2014-11-01

    Microtubules and motor proteins are basic ingredients in many cellular structures and of new biosynthetic ``active'' suspensions. The interaction of microtubules with their surrounding fluid medium depends fundamentally upon the force generation afforded them through cross-linking motile motor proteins. Here we develop a simple mathematical model, based on the statistical mechanics, motor proteins binding and unbinding, to study the generation of active fluid stresses. We study the role and contributions of ``polarity sorting'' and ``tether'' relaxation on the generation of intrinsic, destabilizing stresses.

  1. Probabilistic Usage of the Multi-Factor Interaction Model

    NASA Technical Reports Server (NTRS)

    Chamis, Christos C.

    2008-01-01

    A Multi-Factor Interaction Model (MFIM) is used to predict the insulating foam mass expulsion during the ascending of a space vehicle. The exponents in the MFIM are evaluated by an available approach which consists of least squares and an optimization algorithm. These results were subsequently used to probabilistically evaluate the effects of the uncertainties in each participating factor in the mass expulsion. The probabilistic results show that the surface temperature dominates at high probabilities and the pressure which causes the mass expulsion at low probabil

  2. An interacting loop model of solar flare bursts

    NASA Technical Reports Server (NTRS)

    Emslie, A. G.

    1981-01-01

    As a result of the strong heating produced at chromospheric levels during a solar flare burst, the local gas pressure can transiently attain very large values in certain regions. The effectiveness of the surrounding magnetic field at confining this high pressure plasma is therefore reduced and the flaring loop becomes free to expand laterally. In so doing it may drive magnetic field lines into neighboring, nonflaring, loops in the same active region, causing magnetic reconnection to take place and triggering another flare burst. The features of this interacting loop model are found to be in good agreement with the energetics and time structure of flare associated solar hard X-ray bursts.

  3. A GDP fluctuation model based on interacting firms

    NASA Astrophysics Data System (ADS)

    Li, Honggang; Gao, Yan

    2008-09-01

    A distinctive feature of the market economies is the short-run fluctuations in output around the trend of long-run growth over time, and we regard this feature is internal to complex economic systems composed of interacting heterogeneous units. To explore such internal mechanisms of macroeconomic fluctuations, we present a multi-agent Keynesian theory-based model, which can provide a good approximation to the key empirical features of the western business cycles in the 20th Century, such as the structure of the autocorrelation function of overall output growth, correlations between the output growth of individual agents over time, the distribution of recessions, etc.

  4. Facilitating Business to Government Interaction Using a Citizen-Centric Web 2.0 Model

    NASA Astrophysics Data System (ADS)

    Dais, Alexandros; Nikolaidou, Mara; Anagnostopoulos, Dimosthenis

    Modelling Business to Government (B2G) interaction is considered to be more complex than Citizen to Government (C2G) interaction, since the concept of authorized citizens, representing the Business while interacting with specific governmental organizations should be explored. Novel interaction models should be introduced, transforming the way Governmental services are delivered to Businesses. To this end, we propose a Web 2.0 citizen-centric model facilitating Business to Government interaction by establishing a social network between citizens and public agencies. All kinds of interactions (B2G, G2G) are expressed as C2G interactions establishing the citizen-centric nature of the proposed interaction model. The architecture of a Web 2.0 platform, named MyCCP, based on the suggested interaction model is also presented, along with a case study illustrating business-to-government interaction to indicate the potential of the suggested model.

  5. The Monash Simple Climate Model: An interactive climate model for teaching

    NASA Astrophysics Data System (ADS)

    Dommenget, Dietmar

    2015-04-01

    The Monash university interactive simple climate model is a web-based interface that allows students and the general public to explore the physical simulation of the climate system with a real global climate model. It is based on the Globally Resolved Energy Balance (GREB) model that simulates most of the main physical processes in the climate system in a very simplistic way and therefore allows very fast and simple climate model simulations. Despite its simplicity the model simulates the mean climate and its response to external forcings, such as doubling of the CO2 concentrations very realistically. The Monash simple climate model web-interface allows you to explore thousands of experiments, scenarios and tutorials in an interactive way. You can do some entertaining and educational puzzles about the interaction of climate dynamics. By turning switches OFF and ON you control physical processes in the climate system ansd see how the interaction of the processes builds up the climate. By testing a number of experiments you learn about the interactions in the climate system and thereby figure out which switch controls what process in the climate system. The presentation will illustrate how this web-base tool works and what are the possibilities in teaching students with this tool are.

  6. Study of interaction in silica glass via model potential approach

    NASA Astrophysics Data System (ADS)

    Mann, Sarita; Rani, Pooja

    2016-05-01

    Silica is one of the most commonly encountered substances in daily life and in electronics industry. Crystalline SiO2 (in several forms: quartz, cristobalite, tridymite) is an important constituent of many minerals and gemstones, both in pure form and mixed with related oxides. Cohesive energy of amorphous SiO2 has been investigated via intermolecular potentials i.e weak Van der Waals interaction and Morse type short-range interaction. We suggest a simple atom-atom based Van der Waals as well as Morse potential to find cohesive energy of glass. It has been found that the study of silica structure using two different model potentials is significantly different. Van der Waals potential is too weak (P.E =0.142eV/molecule) to describe the interaction between silica molecules. Morse potential is a strong potential, earlier given for intramolecular bonding, but if applied for intermolecular bonding, it gives a value of P.E (=-21.92eV/molecule) to appropriately describe the structure of silica.

  7. Investigations and advanced concepts on gyrotron interaction modeling and simulations

    SciTech Connect

    Avramidis, K. A.

    2015-12-15

    In gyrotron theory, the interaction between the electron beam and the high frequency electromagnetic field is commonly modeled using the slow variables approach. The slow variables are quantities that vary slowly in time in comparison to the electron cyclotron frequency. They represent the electron momentum and the high frequency field of the resonant TE modes in the gyrotron cavity. For their definition, some reference frequencies need to be introduced. These include the so-called averaging frequency, used to define the slow variable corresponding to the electron momentum, and the carrier frequencies, used to define the slow variables corresponding to the field envelopes of the modes. From the mathematical point of view, the choice of the reference frequencies is, to some extent, arbitrary. However, from the numerical point of view, there are arguments that point toward specific choices, in the sense that these choices are advantageous in terms of simulation speed and accuracy. In this paper, the typical monochromatic gyrotron operation is considered, and the numerical integration of the interaction equations is performed by the trajectory approach, since it is the fastest, and therefore it is the one that is most commonly used. The influence of the choice of the reference frequencies on the interaction simulations is studied using theoretical arguments, as well as numerical simulations. From these investigations, appropriate choices for the values of the reference frequencies are identified. In addition, novel, advanced concepts for the definitions of these frequencies are addressed, and their benefits are demonstrated numerically.

  8. Modelling cavitation erosion using fluid-material interaction simulations.

    PubMed

    Chahine, Georges L; Hsiao, Chao-Tsung

    2015-10-06

    Material deformation and pitting from cavitation bubble collapse is investigated using fluid and material dynamics and their interaction. In the fluid, a novel hybrid approach, which links a boundary element method and a compressible finite difference method, is used to capture non-spherical bubble dynamics and resulting liquid pressures efficiently and accurately. The bubble dynamics is intimately coupled with a finite-element structure model to enable fluid/structure interaction simulations. Bubble collapse loads the material with high impulsive pressures, which result from shock waves and bubble re-entrant jet direct impact on the material surface. The shock wave loading can be from the re-entrant jet impact on the opposite side of the bubble, the fast primary collapse of the bubble, and/or the collapse of the remaining bubble ring. This produces high stress waves, which propagate inside the material, cause deformation, and eventually failure. A permanent deformation or pit is formed when the local equivalent stresses exceed the material yield stress. The pressure loading depends on bubble dynamics parameters such as the size of the bubble at its maximum volume, the bubble standoff distance from the material wall and the pressure driving the bubble collapse. The effects of standoff and material type on the pressure loading and resulting pit formation are highlighted and the effects of bubble interaction on pressure loading and material deformation are preliminarily discussed.

  9. Theory and modeling of particles with DNA-mediated interactions

    NASA Astrophysics Data System (ADS)

    Licata, Nicholas A.

    2008-05-01

    In recent years significant attention has been attracted to proposals which utilize DNA for nanotechnological applications. Potential applications of these ideas range from the programmable self-assembly of colloidal crystals, to biosensors and nanoparticle based drug delivery platforms. In Chapter I we introduce the system, which generically consists of colloidal particles functionalized with specially designed DNA markers. The sequence of bases on the DNA markers determines the particle type. Due to the hybridization between complementary single-stranded DNA, specific, type-dependent interactions can be introduced between particles by choosing the appropriate DNA marker sequences. In Chapter II we develop a statistical mechanical description of the aggregation and melting behavior of particles with DNA-mediated interactions. In Chapter III a model is proposed to describe the dynamical departure and diffusion of particles which form reversible key-lock connections. In Chapter IV we propose a method to self-assemble nanoparticle clusters using DNA scaffolds. A natural extension is discussed in Chapter V, the programmable self-assembly of nanoparticle clusters where the desired cluster geometry is encoded using DNA-mediated interactions. In Chapter VI we consider a nanoparticle based drug delivery platform for targeted, cell specific chemotherapy. In Chapter VII we present prospects for future research: the connection between DNA-mediated colloidal crystallization and jamming, and the inverse problem in self-assembly.

  10. Modelling cavitation erosion using fluid–material interaction simulations

    PubMed Central

    Chahine, Georges L.; Hsiao, Chao-Tsung

    2015-01-01

    Material deformation and pitting from cavitation bubble collapse is investigated using fluid and material dynamics and their interaction. In the fluid, a novel hybrid approach, which links a boundary element method and a compressible finite difference method, is used to capture non-spherical bubble dynamics and resulting liquid pressures efficiently and accurately. The bubble dynamics is intimately coupled with a finite-element structure model to enable fluid/structure interaction simulations. Bubble collapse loads the material with high impulsive pressures, which result from shock waves and bubble re-entrant jet direct impact on the material surface. The shock wave loading can be from the re-entrant jet impact on the opposite side of the bubble, the fast primary collapse of the bubble, and/or the collapse of the remaining bubble ring. This produces high stress waves, which propagate inside the material, cause deformation, and eventually failure. A permanent deformation or pit is formed when the local equivalent stresses exceed the material yield stress. The pressure loading depends on bubble dynamics parameters such as the size of the bubble at its maximum volume, the bubble standoff distance from the material wall and the pressure driving the bubble collapse. The effects of standoff and material type on the pressure loading and resulting pit formation are highlighted and the effects of bubble interaction on pressure loading and material deformation are preliminarily discussed. PMID:26442140

  11. Shell-model phenomenology of low-momentum interactions

    SciTech Connect

    Schwenk, Achim; Zuker, Andres P.

    2006-12-15

    The first detailed comparison of the low-momentum interaction V{sub lowk} with G matrices is presented. We use overlaps to measure quantitatively the similarity of shell-model matrix elements for different cutoffs and oscillator frequencies. Over a wide range, all sets of V{sub lowk} matrix elements can be approximately obtained from a universal set by a simple scaling. In an oscillator mean-field approach, V{sub lowk} reproduces satisfactorily many features of the single-particle and single-hole spectra on closed-shell nuclei, in particular through remarkably good splittings between spin-orbit partners on top of harmonic oscillator closures. The main deficiencies of pure two-nucleon interactions are associated with binding energies and with the failure to ensure magicity for the extruder-intruder closures. Here, calculations including three-nucleon interactions are most needed. V{sub lowk} makes it possible to define directly a meaningful unperturbed monopole Hamiltonian, for which the inclusion of three-nucleon forces is tractable.

  12. Host-Pathogen Interactions Made Transparent with the Zebrafish Model

    PubMed Central

    Meijer, Annemarie H; Spaink, Herman P

    2011-01-01

    The zebrafish holds much promise as a high-throughput drug screening model for immune-related diseases, including inflammatory and infectious diseases and cancer. This is due to the excellent possibilities for in vivo imaging in combination with advanced tools for genomic and large scale mutant analysis. The context of the embryo’s developing immune system makes it possible to study the contribution of different immune cell types to disease progression. Furthermore, due to the temporal separation of innate immunity from adaptive responses, zebrafish embryos and larvae are particularly useful for dissecting the innate host factors involved in pathology. Recent studies have underscored the remarkable similarity of the zebrafish and human immune systems, which is important for biomedical applications. This review is focused on the use of zebrafish as a model for infectious diseases, with emphasis on bacterial pathogens. Following a brief overview of the zebrafish immune system and the tools and methods used to study host-pathogen interactions in zebrafish, we discuss the current knowledge on receptors and downstream signaling components that are involved in the zebrafish embryo’s innate immune response. We summarize recent insights gained from the use of bacterial infection models, particularly the Mycobacterium marinum model, that illustrate the potential of the zebrafish model for high-throughput antimicrobial drug screening. PMID:21366518

  13. Ions interacting with planar aromatic molecules: Modeling electron transfer reactions

    SciTech Connect

    Forsberg, B. O.; Alexander, J. D.; Chen, T.; Pettersson, A. T.; Gatchell, M.; Cederquist, H.; Zettergren, H.

    2013-02-07

    We present theoretical absolute charge exchange cross sections for multiply charged cations interacting with the Polycyclic Aromatic Hydrocarbon (PAH) molecules pyrene C{sub 14}H{sub 10}, coronene C{sub 24}H{sub 12}, or circumcoronene C{sub 54}H{sub 18}. These planar, nearly circular, PAHs are modelled as conducting, infinitely thin, and perfectly circular discs, which are randomly oriented with respect to straight line ion trajectories. We present the analytical solution for the potential energy surface experienced by an electron in the field of such a charged disc and a point-charge at an arbitrary position. The location and height of the corresponding potential energy barrier from this simple model are in close agreement with those from much more computationally demanding Density Functional Theory (DFT) calculations in a number of test cases. The model results compare favourably with available experimental data on single- and multiple electron transfer reactions and we demonstrate that it is important to include the orientation dependent polarizabilities of the molecules (model discs) in particular for the larger PAHs. PAH ionization energy sequences from DFT are tabulated and used as model inputs. Absolute cross sections for the ionization of PAH molecules, and PAH ionization energies such as the ones presented here may be useful when considering the roles of PAHs and their ions in, e.g., interstellar chemistry, stellar atmospheres, and in related photoabsorption and photoemission spectroscopies.

  14. Interactive patient-specific vascular modeling with sweep surfaces.

    PubMed

    Kretschmer, Jan; Godenschwager, Christian; Preim, Bernhard; Stamminger, Marc

    2013-12-01

    The precise modeling of vascular structures plays a key role in medical imaging applications, such as diagnosis, therapy planning and blood flow simulations. For the simulation of blood flow in particular, high-precision models are required to produce accurate results. It is thus common practice to perform extensive manual data polishing on vascular segmentations prior to simulation. This usually involves a complex tool chain which is highly impractical for clinical on-site application. To close this gap in current blood flow simulation pipelines, we present a novel technique for interactive vascular modeling which is based on implicit sweep surfaces. Our method is able to generate and correct smooth high-quality models based on geometric centerline descriptions on the fly. It supports complex vascular free-form contours and consequently allows for an accurate and fast modeling of pathological structures such as aneurysms or stenoses. We extend the concept of implicit sweep surfaces to achieve increased robustness and applicability as required in the medical field. We finally compare our method to existing techniques and provide case studies that confirm its contribution to current simulation pipelines.

  15. Numerical Modelling of Wave Interaction with Porous Structures

    NASA Astrophysics Data System (ADS)

    Gao, F.; M., D.; M., D.; G., C.

    This paper presents a numerical model for simulating wave interaction with porous structures. By using the free surface-capturing approach together with a novel Cartesian cut cell treatment, the Finite Volume Model calculates the two phase flows out side of porous structure based on the Navier-Stokes equations, while the flow in the porous structure is described by Navier-Stokes type model equations. The free surface of water is treated as a contact discontinuity in the density field which is captured automatically as part of the numerical solution by using a time-accurate artificial compressibility method and high resolution Godunov-type scheme. The numerical model is first calibrated by simple test for a steady flow passing through a porous block. Reasonably good agreements with other numerical results are obtained. After that, the numerical model is used to simulate the breaking wave overtopping a caisson breakwater, protected by a layer of armor units. The results show that the porous armor layer is effective in reducing the overtopping rate as well as in protecting the stability of the caisson breakwater.

  16. A THC Simulator for Modeling Fluid-Rock Interactions

    NASA Astrophysics Data System (ADS)

    Hamidi, Sahar; Galvan, Boris; Heinze, Thomas; Miller, Stephen

    2014-05-01

    Fluid-rock interactions play an essential role in many earth processes, from a likely influence on earthquake nucleation and aftershocks, to enhanced geothermal system, carbon capture and storage (CCS), and underground nuclear waste repositories. In THC models, two-way interactions between different processes (thermal, hydraulic and chemical) are present. Fluid flow influences the permeability of the rock especially if chemical reactions are taken into account. On one hand solute concentration influences fluid properties while, on the other hand, heat can affect further chemical reactions. Estimating heat production from a naturally fractured geothermal systems remains a complex problem. Previous works are typically based on a local thermal equilibrium assumption and rarely consider the salinity. The dissolved salt in fluid affects the hydro- and thermodynamical behavior of the system by changing the hydraulic properties of the circulating fluid. Coupled thermal-hydraulic-chemical models (THC) are important for investigating these processes, but what is needed is a coupling to mechanics to result in THMC models. Although similar models currently exist (e.g. PFLOTRAN), our objective here is to develop algorithms for implementation using the Graphics Processing Unit (GPU) computer architecture to be run on GPU clusters. To that aim, we present a two-dimensional numerical simulation of a fully coupled non-isothermal non-reactive solute flow. The thermal part of the simulation models heat transfer processes for either local thermal equilibrium or nonequilibrium cases, and coupled to a non-reactive mass transfer described by a non-linear diffusion/dispersion model. The flow process of the model includes a non-linear Darcian flow for either saturated or unsaturated scenarios. For the unsaturated case, we use the Richards' approximation for a mixture of liquid and gas phases. Relative permeability and capillary pressure are determined by the van Genuchten relations

  17. Multilayer adsorption model for the protein-ligand interaction

    NASA Astrophysics Data System (ADS)

    Varela, L. M.; Garcia, M.; Perez-Rodriguez, M.; Taboada, P.; Ruso, J. M.; Mosquera, V.

    2001-05-01

    In the present work we present a theoretical formalism based on the combination of the Brunauer-Emmet-Teller multilayer adsorption model with an electrolytic adsorbate, and the results are used to predict binding isotherms of several synthetic penicillin drugs onto human serum albumin. The occurrence of adsorption maxima in these binding processes is correctly predicted by this noncooperative binding model and it is demonstrated to be due to the ionic character of the adsorbate. The effect of the hydrophobic interactions between adsorbate monomers on the value of the maximum number of adsorbed particles is also a matter of study, and it is proven that this number increases with increasing hydrophobic character of the adsorbate.

  18. An interacting loop model for solar flare bursts

    NASA Technical Reports Server (NTRS)

    Emslie, A. G.

    1981-01-01

    A schematic model is presented which attempts to explain the quasi-periodic behavior (on a timescale of less than or approximately equal to 10 s) frequency observed in solar hard X-ray bursts. It is shown how, as a result of the strong heating produced during a solar flare burst, the local gas pressure can transiently attain very large values in regions corresponding to the upper preflare chromosphere. The effectiveness of the surrounding magnetic field at confining this high pressure plasma is therefore reduced and the flaring loop becomes free to expand laterally. In so doing it may drive magnetic field lines into neighboring, non-flaring, loops in the same active region, causing magnetic reconnection to take place and triggering another flare burst. The features of this interacting loop model are found to be in good agreement with the energetics and time structure of flare-associated solar hard X-ray bursts.

  19. Nagaoka’s atomic model and hyperfine interactions

    PubMed Central

    INAMURA, Takashi T.

    2016-01-01

    The prevailing view of Nagaoka’s “Saturnian” atom is so misleading that today many people have an erroneous picture of Nagaoka’s vision. They believe it to be a system involving a ‘giant core’ with electrons circulating just outside. Actually, though, in view of the Coulomb potential related to the atomic nucleus, Nagaoka’s model is exactly the same as Rutherford’s. This is true of the Bohr atom, too. To give proper credit, Nagaoka should be remembered together with Rutherford and Bohr in the history of the atomic model. It is also pointed out that Nagaoka was a pioneer of understanding hyperfine interactions in order to study nuclear structure. PMID:27063182

  20. Modeling of a UV laser beam—silicon nitride interaction

    NASA Astrophysics Data System (ADS)

    Dgheim, J. A.

    2016-11-01

    A numerical model is developed to study heat and radiation transfers during the interaction between a UV laser beam and silicon nitride. The laser beam has temporal Gaussian or Gate shapes of a wavelength of 247 nm, with pulse duration of 27 ns. The mathematical model is based on the heat equation coupled to Lambert-Beer relationship by taking into account the conduction, convection and radiation phenomena. The resulting equations are schemed by the finite element method. Comparison with the literature shows qualitative and quantitative agreements. The investigated parameters are the temperature, the timing of the melting process and the melting phase thickness. The effects of the laser fluences, ranging from 500 to 16 000 J.m-2, the Gaussian and Gate shapes on the heat transfer, and the melting phenomenon are studied.

  1. Interactive display of molecular models using a microcomputer system

    NASA Technical Reports Server (NTRS)

    Egan, J. T.; Macelroy, R. D.

    1980-01-01

    A simple, microcomputer-based, interactive graphics display system has been developed for the presentation of perspective views of wire frame molecular models. The display system is based on a TERAK 8510a graphics computer system with a display unit consisting of microprocessor, television display and keyboard subsystems. The operating system includes a screen editor, file manager, PASCAL and BASIC compilers and command options for linking and executing programs. The graphics program, written in USCD PASCAL, involves the centering of the coordinate system, the transformation of centered model coordinates into homogeneous coordinates, the construction of a viewing transformation matrix to operate on the coordinates, clipping invisible points, perspective transformation and scaling to screen coordinates; commands available include ZOOM, ROTATE, RESET, and CHANGEVIEW. Data file structure was chosen to minimize the amount of disk storage space. Despite the inherent slowness of the system, its low cost and flexibility suggests general applicability.

  2. Accurate first principles model potentials for intermolecular interactions.

    PubMed

    Gordon, Mark S; Smith, Quentin A; Xu, Peng; Slipchenko, Lyudmila V

    2013-01-01

    The general effective fragment potential (EFP) method provides model potentials for any molecule that is derived from first principles, with no empirically fitted parameters. The EFP method has been interfaced with most currently used ab initio single-reference and multireference quantum mechanics (QM) methods, ranging from Hartree-Fock and coupled cluster theory to multireference perturbation theory. The most recent innovations in the EFP model have been to make the computationally expensive charge transfer term much more efficient and to interface the general EFP dispersion and exchange repulsion interactions with QM methods. Following a summary of the method and its implementation in generally available computer programs, these most recent new developments are discussed.

  3. Double scaling in tensor models with a quartic interaction

    NASA Astrophysics Data System (ADS)

    Dartois, Stéphane; Gurau, Razvan; Rivasseau, Vincent

    2013-09-01

    In this paper we identify and analyze in detail the subleading contributions in the 1 /N expansion of random tensors, in the simple case of a quartically interacting model. The leading order for this 1 /N expansion is made of graphs, called melons, which are dual to particular triangulations of the D-dimensional sphere, closely related to the "stacked" triangulations. For D < 6 the subleading behavior is governed by a larger family of graphs, hereafter called cherry trees, which are also dual to the D-dimensional sphere. They can be resummed explicitly through a double scaling limit. In sharp contrast with random matrix models, this double scaling limit is stable. Apart from its unexpected upper critical dimension 6, it displays a singularity at fixed distance from the origin and is clearly the first step in a richer set of yet to be discovered multi-scaling limits.

  4. Bifurcation analysis of a photoreceptor interaction model for Retinitis Pigmentosa

    NASA Astrophysics Data System (ADS)

    Camacho, Erika T.; Radulescu, Anca; Wirkus, Stephen

    2016-09-01

    Retinitis Pigmentosa (RP) is the term used to describe a diverse set of degenerative eye diseases affecting the photoreceptors (rods and cones) in the retina. This work builds on an existing mathematical model of RP that focused on the interaction of the rods and cones. We non-dimensionalize the model and examine the stability of the equilibria. We then numerically investigate other stable modes that are present in the system for various parameter values and relate these modes to the original problem. Our results show that stable modes exist for a wider range of parameter values than the stability of the equilibrium solutions alone, suggesting that additional approaches to preventing cone death may exist.

  5. Bayesian Safety Risk Modeling of Human-Flightdeck Automation Interaction

    NASA Technical Reports Server (NTRS)

    Ancel, Ersin; Shih, Ann T.

    2015-01-01

    Usage of automatic systems in airliners has increased fuel efficiency, added extra capabilities, enhanced safety and reliability, as well as provide improved passenger comfort since its introduction in the late 80's. However, original automation benefits, including reduced flight crew workload, human errors or training requirements, were not achieved as originally expected. Instead, automation introduced new failure modes, redistributed, and sometimes increased workload, brought in new cognitive and attention demands, and increased training requirements. Modern airliners have numerous flight modes, providing more flexibility (and inherently more complexity) to the flight crew. However, the price to pay for the increased flexibility is the need for increased mode awareness, as well as the need to supervise, understand, and predict automated system behavior. Also, over-reliance on automation is linked to manual flight skill degradation and complacency in commercial pilots. As a result, recent accidents involving human errors are often caused by the interactions between humans and the automated systems (e.g., the breakdown in man-machine coordination), deteriorated manual flying skills, and/or loss of situational awareness due to heavy dependence on automated systems. This paper describes the development of the increased complexity and reliance on automation baseline model, named FLAP for FLightdeck Automation Problems. The model development process starts with a comprehensive literature review followed by the construction of a framework comprised of high-level causal factors leading to an automation-related flight anomaly. The framework was then converted into a Bayesian Belief Network (BBN) using the Hugin Software v7.8. The effects of automation on flight crew are incorporated into the model, including flight skill degradation, increased cognitive demand and training requirements along with their interactions. Besides flight crew deficiencies, automation system

  6. Molecular interactions between amantadine and model cell membranes.

    PubMed

    Wu, Fu-Gen; Yang, Pei; Zhang, Chi; Li, Bolin; Han, Xiaofeng; Song, Minghu; Chen, Zhan

    2014-07-22

    Sum frequency generation (SFG) vibrational spectroscopy was applied to study molecular interactions between amantadine and substrate supported lipid bilayers serving as model cell membranes. Both isotopically asymmetric and symmetric lipid bilayers were used in the research. SFG results elucidated how the water-soluble drug, amantadine, influenced the packing state of each leaflet of a lipid bilayer and how the drugs affected the lipid flip-flop process. It is difficult to achieve such detailed molecular-level information using other analytical techniques. Especially, from the flip-flop rate change of isotopically asymmetric lipid bilayer induced by amantadine, important information on the drug-membrane interaction mechanism can be derived. The results show that amantadine can be associated with zwitterionic PC bilayers but has a negligible influence on the flip-flop behavior of PC molecules unless at high concentrations. Different effects of amantadine on the lipid bilayer were observed for the negatively charged DPPG bilayer; low concentration amantadine (e.g., 0.20 mM) in the subphase could immediately disturb the outer lipid leaflet and then the lipid associated amantadine molecules gradually reorganize to cause the outer leaflet to return to the original orderly packed state. Higher concentration amantadine (e.g., 5.0 mM) immediately disordered the packing state of the outer lipid leaflet. For both the high and low concentration cases, amantadine molecules only bind to the outer PG leaflet and cannot translocate to the inner layer. The presence of amantadine within the negatively charged lipid layers has certain implications for using liposomes as drug delivery carriers for amantadine. Besides, by using PC or PG bilayers with both leaflets deuterated, we were able to examine how amantadine is distributed and/or oriented within the lipid bilayer. The present work demonstrates that SFG results can provide an in-depth understanding of the molecular mechanisms of

  7. Interactive training model of TRIZ for mechanical engineers in China

    NASA Astrophysics Data System (ADS)

    Tan, Runhua; Zhang, Huangao

    2014-03-01

    Innovation is a process of taking an original idea and converting it into a business value, in which the engineers face some inventive problems which can be solved hardly by experience. TRIZ, as a new theory for companies in China, provides both conceptual and procedural knowledge for finding and solving inventive problems. Because the government plays a leading role in the diffusion of TRIZ, too many companies from different industries are waiting to be trained, but the quantity of the trainers mastering TRIZ is incompatible with that requirement. In this context, to improve the training effect, an interactive training model of TRIZ for the mechanical engineers in China is developed and the implementation in the form of training classes is carried out. The training process is divided into 6 phases as follows: selecting engineers, training stage-1, finding problems, training stage-2, finding solutions and summing up. The government, TRIZ institutions and companies to join the programs interact during the process. The government initiates and monitors a project in form of a training class of TRIZ and selects companies to join the programs. Each selected companies choose a few engineers to join the class and supervises the training result. The TRIZ institutions design the training courses and carry out training curriculum. With the beginning of the class, an effective communication channel is established by means of interview, discussion face to face, E-mail, QQ and so on. After two years training practices, the results show that innovative abilities of the engineers to join and pass the final examinations increased distinctly, and most of companies joined the training class have taken congnizance of the power of TRIZ for product innovation. This research proposes an interactive training model of TRIZ for mechanical engineers in China to expedite the knowledge diffusion of TRIZ.

  8. Effective Lagrangian Models for gauge theories of fundamental interactions

    NASA Astrophysics Data System (ADS)

    Sannino, Francesco

    The non abelian gauge theory which describes, in the perturbative regime, the strong interactions is Quantum Chromodynamics (QCD). Quarks and gluons are the fundamental degrees of freedom of the theory. A key feature of the theory (due to quantum corrections) is asymptotic freedom, i.e. the strong coupling constant increases as the energy scale of interest decreases. The perturbative approach becomes unreliable below a characteristic scale of the theory (Λ). Quarks and gluons confine themselves into colorless particles called hadrons (pions, protons,/...). The latter are the true physical states of the theory. We need to investigate alternative ways to describe strong interactions, and in general any asymptotically free theory, in the non perturbative regime. This is the fundamental motivation of the present thesis. Although the underlying gauge theory cannot be easily treated in the non perturbative regime we can still use its global symmetries as a guide to build Effective Lagrangian Models. These models will be written directly in terms of the colorless physical states of the theory, i.e. hadrons.

  9. Template-Based Modeling of Protein-RNA Interactions

    PubMed Central

    Zheng, Jinfang; Kundrotas, Petras J.; Vakser, Ilya A.

    2016-01-01

    Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding proteins are to be discovered. Due to limitations of experimental approaches, computational techniques are needed for characterization of protein-RNA interactions. Although much progress has been made, adequate methodologies reliably providing atomic resolution structural details are still lacking. Although protein-RNA free docking approaches proved to be useful, in general, the template-based approaches provide higher quality of predictions. Templates are key to building a high quality model. Sequence/structure relationships were studied based on a representative set of binary protein-RNA complexes from PDB. Several approaches were tested for pairwise target/template alignment. The analysis revealed a transition point between random and correct binding modes. The results showed that structural alignment is better than sequence alignment in identifying good templates, suitable for generating protein-RNA complexes close to the native structure, and outperforms free docking, successfully predicting complexes where the free docking fails, including cases of significant conformational change upon binding. A template-based protein-RNA interaction modeling protocol PRIME was developed and benchmarked on a representative set of complexes. PMID:27662342

  10. Template-Based Modeling of Protein-RNA Interactions.

    PubMed

    Zheng, Jinfang; Kundrotas, Petras J; Vakser, Ilya A; Liu, Shiyong

    2016-09-01

    Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding proteins are to be discovered. Due to limitations of experimental approaches, computational techniques are needed for characterization of protein-RNA interactions. Although much progress has been made, adequate methodologies reliably providing atomic resolution structural details are still lacking. Although protein-RNA free docking approaches proved to be useful, in general, the template-based approaches provide higher quality of predictions. Templates are key to building a high quality model. Sequence/structure relationships were studied based on a representative set of binary protein-RNA complexes from PDB. Several approaches were tested for pairwise target/template alignment. The analysis revealed a transition point between random and correct binding modes. The results showed that structural alignment is better than sequence alignment in identifying good templates, suitable for generating protein-RNA complexes close to the native structure, and outperforms free docking, successfully predicting complexes where the free docking fails, including cases of significant conformational change upon binding. A template-based protein-RNA interaction modeling protocol PRIME was developed and benchmarked on a representative set of complexes.

  11. Interactions of PAMAM dendrimers with negatively charged model biomembranes.

    PubMed

    Yanez Arteta, Marianna; Ainalem, Marie-Louise; Porcar, Lionel; Martel, Anne; Coker, Helena; Lundberg, Dan; Chang, Debby P; Soltwedel, Olaf; Barker, Robert; Nylander, Tommy

    2014-11-13

    We have investigated the interactions between cationic poly(amidoamine) (PAMAM) dendrimers of generation 4 (G4), a potential gene transfection vector, with net-anionic model biomembranes composed of different ratios of zwitterionic phosphocholine (PC) and anionic phospho-L-serine (PS) phospholipids. Two types of model membranes were used: solid-supported bilayers, prepared with lipids carrying palmitoyl-oleoyl (PO) and diphytanoyl (DPh) acyl chains, and free-standing bilayers, formed at the interface between two aqueous droplets in oil (droplet interface bilayers, DIBs) using the DPh-based lipids. G4 dendrimers were found to translocate through POPC:POPS bilayers deposited on silica surfaces. The charge density of the bilayer affects translocation, which is reduced when the ionic strength increases. This shows that the dendrimer-bilayer interactions are largely controlled by their electrostatic attraction. The structure of the solid-supported bilayers remains intact upon translocation of the dendrimer. However, the amount of lipids in the bilayer decreases and dendrimer/lipid aggregates are formed in bulk solution, which can be deposited on the interfacial layers upon dilution of the system with dendrimer-free solvent. Electrophysiology measurements on DIBs confirm that G4 dendrimers cross the lipid membranes containing PS, which then become more permeable to ions. The obtained results have implications for PAMAM dendrimers as delivery vehicles to cells.

  12. Modeling aerosol-water interactions in subsaturated and supersaturated environments

    NASA Astrophysics Data System (ADS)

    Fountoukis, Christos

    The current dissertation is motivated by the need for an improved understanding of aerosol - water interactions both in subsaturated and supersaturated atmospheric conditions with a strong emphasis on air pollution and climate change modeling. A cloud droplet formation parameterization was developed to (i) predict droplet formation from a lognormal representation of aerosol size distribution and composition, and, (ii) include a size-dependant mass transfer coefficient for the growth of water droplets which explicitly accounts for the impact of organics on droplet growth kinetics. The parameterization unravels most of the physics of droplet formation and is in remarkable agreement with detailed numerical parcel model simulations, even for low values of the accommodation coefficient. The parameterization offers a much needed rigorous and computationally inexpensive framework for directly linking complex chemical effects on aerosol activation in global climate models. The new aerosol activation parameterization was also tested against observations from highly polluted clouds (within the vicinity of power plant plumes). Remarkable closure was achieved (much less than the 20% measurement uncertainty). The error in predicted cloud droplet concentration was mostly sensitive to updraft velocity. Optimal closure is obtained if the water vapor uptake coefficient is equal to 0.06. These findings can serve as much needed constraints in modeling of aerosol-cloud interactions in the North America. Aerosol-water interactions in ambient relative humidities less than 100% were studied using a thermodynamic equilibrium model for inorganic aerosol and a three dimensional air quality model. We developed a new thermodynamic equilibrium model, ISORROPIA-II, which predicts the partitioning of semi-volatiles and the phase state of K+/Ca2+/M g2+ /NH4+/Na+/SO4 2-/NO3-/Cl-/H2O aerosols. A comprehensive evaluation of its performance was conducted over a wide range of atmospherically relevant

  13. Maxwell's equations-based dynamic laser-tissue interaction model.

    PubMed

    Ahmed, Elharith M; Barrera, Frederick J; Early, Edward A; Denton, Michael L; Clark, C D; Sardar, Dhiraj K

    2013-12-01

    Since its invention in the early 1960s, the laser has been used as a tool for surgical, therapeutic, and diagnostic purposes. To achieve maximum effectiveness with the greatest margin of safety it is important to understand the mechanisms of light propagation through tissue and how that light affects living cells. Lasers with novel output characteristics for medical and military applications are too often implemented prior to proper evaluation with respect to tissue optical properties and human safety. Therefore, advances in computational models that describe light propagation and the cellular responses to laser exposure, without the use of animal models, are of considerable interest. Here, a physics-based laser-tissue interaction model was developed to predict the dynamic changes in the spatial and temporal temperature rise during laser exposure to biological tissues. Unlike conventional models, the new approach is grounded on the rigorous electromagnetic theory that accounts for wave interference, polarization, and nonlinearity in propagation using a Maxwell's equations-based technique.

  14. Incremental and unifying modelling formalism for biological interaction networks

    PubMed Central

    Yartseva, Anastasia; Klaudel, Hanna; Devillers, Raymond; Képès, François

    2007-01-01

    Background An appropriate choice of the modeling formalism from the broad range of existing ones may be crucial for efficiently describing and analyzing biological systems. Results We propose a new unifying and incremental formalism for the representation and modeling of biological interaction networks. This formalism allows automated translations into other formalisms, thus enabling a thorough study of the dynamic properties of a biological system. As a first illustration, we propose a translation into the R. Thomas' multivalued logical formalism which provides a possible semantics; a methodology for constructing such models is presented on a classical benchmark: the λ phage genetic switch. We also show how to extract from our model a classical ODE description of the dynamics of a system. Conclusion This approach provides an additional level of description between the biological and mathematical ones. It yields, on the one hand, a knowledge expression in a form which is intuitive for biologists and, on the other hand, its representation in a formal and structured way. PMID:17996051

  15. Wave-current interactions: model development and preliminary results

    NASA Astrophysics Data System (ADS)

    Mayet, Clement; Lyard, Florent; Ardhuin, Fabrice

    2013-04-01

    The coastal area concentrates many uses that require integrated management based on diagnostic and predictive tools to understand and anticipate the future of pollution from land or sea, and learn more about natural hazards at sea or activity on the coast. The realistic modelling of coastal hydrodynamics needs to take into account various processes which interact, including tides, surges, and sea state (Wolf [2008]). These processes act at different spatial scales. Unstructured-grid models have shown the ability to satisfy these needs, given that a good mesh resolution criterion is used. We worked on adding a sea state forcing in a hydrodynamic circulation model. The sea state model is the unstructured version of WAVEWATCH III c (Tolman [2008]) (which version is developed at IFREMER, Brest (Ardhuin et al. [2010]) ), and the hydrodynamic model is the 2D barotropic module of the unstructured-grid finite element model T-UGOm (Le Bars et al. [2010]). We chose to use the radiation stress approach (Longuet-Higgins and Stewart [1964]) to represent the effect of surface waves (wind waves and swell) in the barotropic model, as previously done by Mastenbroek et al. [1993]and others. We present here some validation of the model against academic cases : a 2D plane beach (Haas and Warner [2009]) and a simple bathymetric step with analytic solution for waves (Ardhuin et al. [2008]). In a second part we present realistic application in the Ushant Sea during extreme event. References Ardhuin, F., N. Rascle, and K. Belibassakis, Explicit wave-averaged primitive equations using a generalized Lagrangian mean, Ocean Modelling, 20 (1), 35-60, doi:10.1016/j.ocemod.2007.07.001, 2008. Ardhuin, F., et al., Semiempirical Dissipation Source Functions for Ocean Waves. Part I: Definition, Calibration, and Validation, J. Phys. Oceanogr., 40 (9), 1917-1941, doi:10.1175/2010JPO4324.1, 2010. Haas, K. A., and J. C. Warner, Comparing a quasi-3D to a full 3D nearshore circulation model: SHORECIRC and

  16. Interacting 3-form dark energy models: Distinguishing interactions and avoiding the Little Sibling of the Big Rip

    NASA Astrophysics Data System (ADS)

    Morais, João; Bouhmadi-López, Mariam; Kumar, K. Sravan; Marto, João; Tavakoli, Yaser

    2017-03-01

    In this paper we consider 3-form dark energy (DE) models with interactions in the dark sector. We aim to distinguish the phenomenological interactions that are defined through the dark matter (DM) and the DE energy densities. We do our analysis mainly in two stages. In the first stage, we identify the non-interacting 3-form DE model which generically leads to an abrupt late-time cosmological event which is known as the little sibling of the Big Rip (LSBR). We classify the interactions which can possibly avoid this late-time abrupt event. We also study the parameter space of the model that is consistent with the interaction between DM and DE energy densities at present as indicated by recent studies based on BAO and SDSS data. In the later stage, we observationally distinguish those interactions using the statefinder hierarchy parameters { S3(1), S4(1) } , { S3(1), S5(1)} . We also compute the growth factor parameter ɛ(z) for the various interactions we consider herein and use the composite null diagnostic (CND) { S3(1), ɛ(z) } as a tool to characterise those interactions by measuring their departures from the concordance model. In addition, we make a preliminary analysis of our model in light of the recently released data by SDSS III on the measurement of the linear growth rate of structure.

  17. Multiscale models for synoptic-mesoscale interactions in the ocean

    NASA Astrophysics Data System (ADS)

    Grooms, Ian; Shafer Smith, K.; Majda, Andrew J.

    2012-11-01

    Multiscale analysis is used to derive two sets of coupled models, each based on the same distinguished limit, to represent the interaction of the midlatitude oceanic synoptic scale-where coherent features such as jets and rings form-and the mesoscale, defined by the internal deformation scale. The synoptic scale and mesoscale overlap at low and mid latitudes, and are hence synonymous in much of the oceanographic literature; at higher latitudes the synoptic scale can be an order of magnitude larger than the deformation scale, which motivates our asymptotic approach and our nonstandard terminology. In the first model the synoptic dynamics are described by ‘Large Amplitude Geostrophic’ (LAG) equations while the eddy dynamics are quasigeostrophic. This model has order one isopycnal variation on the synoptic scale; the synoptic dynamics respond to an eddy momentum flux while the eddy dynamics respond to the baroclinically unstable synoptic density gradient. The second model assumes small isopycnal variation on the synoptic scale, but allows for a planetary scale background density gradient that may be fixed or evolved on a slower time scale. Here the large-scale equations are just the barotropic quasigeostrophic equations, and the mesoscale is modeled by the baroclinic quasigeostrophic equations. The synoptic dynamics now respond to both eddy momentum and buoyancy fluxes, but the small-scale eddy dynamics are simply advected by the synoptic-scale flow-there is no baroclinic production term in the eddy equations. The energy budget is closed by deriving an equation for the slow evolution of the eddy energy, which ensures that energy gained or lost by the synoptic-scale flow is reflected in a corresponding loss or gain by the eddies. This latter model, aided by the eddy energy equation-a key result of this paper-provides a conceptual basis through which to understand the classic baroclinic turbulence cycle.

  18. Modelling the interaction between flooding events and economic growth

    NASA Astrophysics Data System (ADS)

    Grames, Johanna; Fürnkranz-Prskawetz, Alexia; Grass, Dieter; Viglione, Alberto; Blöschl, Günter

    2016-04-01

    Recently socio-hydrology models have been proposed to analyze the interplay of community risk-coping culture, flooding damage and economic growth. These models descriptively explain the feedbacks between socio-economic development and natural disasters such as floods. Complementary to these descriptive models, we develop a dynamic optimization model, where the inter-temporal decision of an economic agent interacts with the hydrological system. This interdisciplinary approach matches with the goals of Panta Rhei i.e. to understand feedbacks between hydrology and society. It enables new perspectives but also shows limitations of each discipline. Young scientists need mentors from various scientific backgrounds to learn their different research approaches and how to best combine them such that interdisciplinary scientific work is also accepted by different science communities. In our socio-hydrology model we apply a macro-economic decision framework to a long-term flood-scenario. We assume a standard macro-economic growth model where agents derive utility from consumption and output depends on physical capital that can be accumulated through investment. To this framework we add the occurrence of flooding events which will destroy part of the capital. We identify two specific periodic long term solutions and denote them rich and poor economies. Whereas rich economies can afford to invest in flood defense and therefore avoid flood damage and develop high living standards, poor economies prefer consumption instead of investing in flood defense capital and end up facing flood damages every time the water level rises. Nevertheless, they manage to sustain at least a low level of physical capital. We identify optimal investment strategies and compare simulations with more frequent and more intense high water level events.

  19. An Efficient Bayesian Model Selection Approach for Interacting Quantitative Trait Loci Models With Many Effects

    PubMed Central

    Yi, Nengjun; Shriner, Daniel; Banerjee, Samprit; Mehta, Tapan; Pomp, Daniel; Yandell, Brian S.

    2007-01-01

    We extend our Bayesian model selection framework for mapping epistatic QTL in experimental crosses to include environmental effects and gene–environment interactions. We propose a new, fast Markov chain Monte Carlo algorithm to explore the posterior distribution of unknowns. In addition, we take advantage of any prior knowledge about genetic architecture to increase posterior probability on more probable models. These enhancements have significant computational advantages in models with many effects. We illustrate the proposed method by detecting new epistatic and gene–sex interactions for obesity-related traits in two real data sets of mice. Our method has been implemented in the freely available package R/qtlbim (http://www.qtlbim.org) to facilitate the general usage of the Bayesian methodology for genomewide interacting QTL analysis. PMID:17483424

  20. Interlayer-interaction dependence of latent heat in the Heisenberg model on a stacked triangular lattice with competing interactions.

    PubMed

    Tamura, Ryo; Tanaka, Shu

    2013-11-01

    We study the phase transition behavior of a frustrated Heisenberg model on a stacked triangular lattice by Monte Carlo simulations. The model has three types of interactions: the ferromagnetic nearest-neighbor interaction J(1) and antiferromagnetic third nearest-neighbor interaction J(3) in each triangular layer and the ferromagnetic interlayer interaction J([perpendicular]). Frustration comes from the intralayer interactions J(1) and J(3). We focus on the case that the order parameter space is SO(3)×C(3). We find that the model exhibits a first-order phase transition with breaking of the SO(3) and C(3) symmetries at finite temperature. We also discover that the transition temperature increases but the latent heat decreases as J([perpendicular])/J(1) increases, which is opposite to the behavior observed in typical unfrustrated three-dimensional systems.

  1. Incorporating swarm data into plasma models and plasma surface interactions

    NASA Astrophysics Data System (ADS)

    Makabe, Toshiaki

    2009-10-01

    Since the mid-1980s, modeling of non-equilibrium plasmas in a collisional region driven at radio frequency has been developed at pressure greater than ˜Pa. The collisional plasma has distinct characteristics induced by a quantum property of each of feed gas molecules through collisions with electrons or heavy particles. That is, there exists a proper function caused by chemically active radicals, negative-ions, and radiations based on a molecular quantum structure through short-range interactions mainly with electrons. This differs from high-density, collisionless plasma controlled by the long-range Coulomb interaction. The quantum property in the form of the collision cross section is the first essential through swarm parameters in order to investigate the collisional plasma structure and to predict the function. These structure and function, of course, appear under a self- organized spatiotemporal distribution of electrons and positive ions subject to electromagnetic theory, i.e., bulk-plasma and ion-sheath. In a plasma interacting with a surface, the flux, energy and angle of particles incident on a surface are basic quantities. It will be helpful to learn the limits of the swarm data in a quasi-equilibrium situation and to find a way out of the difficulty, when we predict the collisional plasma, the function, and related surface processes. In this talk we will discuss some of these experiences in the case of space and time varying radiofrequency plasma and the micro/nano-surface processes. This work is partly supported by Global-COE program in Keio University, granted by MEXT Japan.

  2. The XY model with Dzyaloshinskii-Moriya interaction

    SciTech Connect

    D'Souza, Ransell

    2014-04-24

    One can get spin-orbit interaction of the magnetic ions, besides the strong Heisenberg interaction, known as the Dzyaloshinskii-Moriya (DM) interaction. We show the effect of the DM interaction on the excitation spectrum. We also show here the magnetic Susceptibility and ferroelectric polarization of the system in a longitudinal magnetic field.

  3. Modeling interaction of deep groundwaters with bentonite and radionuclide speciation

    SciTech Connect

    Wanner, H.

    1987-12-01

    Based on available experimental data on the interaction of sodium bentonite and groundwater, a model has been developed that represents a means of extrapolation from laboratory data to the conditions in compacted bentonite. The basic reactions between sodium bentonite and groundwater are described by an ion exchange model for sodium, potassium, magnesium, and calcium. The model also assumes equilibrium with calcite and quartz. The calculations are carried out for two types of granitic groundwater: the Swiss reference groundwater (ionic strength I = 0.24 M) and the standard Swedish groundwater (I = 0.0044 M). It is calculated that the pore water of compacted sodium bentonite will have a pH of 9.7 and a carbonate activity of 8 x 10/sup -4/ M if the dry bentonite is saturated with Swiss reference groundwater; it will have a pH near 10.2 and )CO/sub 3//sup 2-/) = 8 x 10/sup -3/ M for standard Swedish groundwater. The long-term situation, which is important for nuclear waste disposal, is modeled by the assumption that the near field of a radioactive waste repository behaves like a mixing tank. It is calculated that sodium bentonite will be slowly converted to calcium bentonite over a long period. The model is used to calculate short- and long-term maximum solubilities of thorium, uranium, neptunium, plutonium, americium, and technetium in the near-field pore water of a potential Swiss nuclear waste repository. The redox potential in the near field is assumed to be controlled by the corrosion products of the iron canister.

  4. Mathematical models: a key to understanding HIV envelope interactions?

    PubMed

    Magnus, Carsten; Brandenberg, Oliver F; Rusert, Peter; Trkola, Alexandra; Regoes, Roland R

    2013-12-15

    The spikes of the human immunodeficiency virus (HIV) mediate viral entry and are the most important targets for neutralizing antibodies. Each spike consists of three identical subunits. The role of the spike's subunits in antibody binding is not fully understood. One experimental approach to analyze trimer function uses assays with mixed envelope trimer expressing cells or viruses. As these experiments do not allow direct observation of subunit functions, mathematical models are required to interpret them. Here we describe a modeling framework to study (i) the interaction of the V1V2 loop with epitopes on the V3 loop and (ii) the composition of quaternary epitopes. In a first step we identify which trimers can form in these assays and how they function under antibody binding. We then derive the behavior of an average trimer. We contrast two experimental reporting systems and list their advantages and disadvantages. In these experiments trimer formation might not be perfectly random and we show how these effects can be tested. As we still lack a potent vaccine against HIV, and this vaccine surely has to stimulate the production of neutralizing antibodies, mixed trimer approaches in combination with mathematical models will help to identify vulnerable sites of the HIV spike.

  5. Fluid-Structure interaction modeling in deformable porous arteries

    NASA Astrophysics Data System (ADS)

    Zakerzadeh, Rana; Zunino, Paolo

    2015-11-01

    A computational framework is developed to study the coupling of blood flow in arteries interacting with a poroelastic arterial wall featuring possibly large deformations. Blood is modeled as an incompressible, viscous, Newtonian fluid using the Navier-Stokes equations and the arterial wall consists of a thick material which is modeled as a Biot system that describes the mechanical behavior of a homogeneous and isotropic elastic skeleton, and connecting pores filled with fluid. Discretization via finite element method leads to the system of nonlinear equations and a Newton-Raphson scheme is adopted to solve the resulting nonlinear system through consistent linearization. Moreover, interface conditions are imposed on the discrete level via mortar finite elements or Nitsche's coupling. The discrete linearized coupled FSI system is solved by means of a splitting strategy, which allows solving the Navier-Stokes and Biot equations separately. The numerical results investigate the effects of proroelastic parameters on the pressure wave propagation in arteries, filtration of incompressible fluids through the porous media, and the structure displacement. The fellowship support from the Computational Modeling & Simulation PhD program at University of Pittsburgh for Rana Zakerzadeh is gratefully acknowledged.

  6. A physical model of sensorimotor interactions during locomotion

    NASA Astrophysics Data System (ADS)

    Klein, Theresa J.; Lewis, M. Anthony

    2012-08-01

    In this paper, we describe the development of a bipedal robot that models the neuromuscular architecture of human walking. The body is based on principles derived from human muscular architecture, using muscles on straps to mimic agonist/antagonist muscle action as well as bifunctional muscles. Load sensors in the straps model Golgi tendon organs. The neural architecture is a central pattern generator (CPG) composed of a half-center oscillator combined with phase-modulated reflexes that is simulated using a spiking neural network. We show that the interaction between the reflex system, body dynamics and CPG results in a walking cycle that is entrained to the dynamics of the system. We also show that the CPG helped stabilize the gait against perturbations relative to a purely reflexive system, and compared the joint trajectories to human walking data. This robot represents a complete physical, or ‘neurorobotic’, model of the system, demonstrating the usefulness of this type of robotics research for investigating the neurophysiological processes underlying walking in humans and animals.

  7. Interacting varying ghost dark energy models in general relativity

    NASA Astrophysics Data System (ADS)

    Khurshudyan, Martiros; Khurshudyan, Amalya; Myrzakulov, Ratbay

    2015-06-01

    Motivated by recent developments in Cosmology we would like to consider an extension of the Ghost DE which we will name as varying Ghost DE. Ghost DE like other models was introduced recently as a possible way to explain accelerated expansion of the Universe. For the phenomenological origin of the varying Ghost dark energy in our Universe we can suggest an existence of some unknown dynamics between the Ghost Dark energy and a fluid which evaporated completely making sense of the proposed effect. Moreover, we assume that this was in the epochs and scales which are unreachable by present-day experiments, like in very early Universe. In this study we will investigate the model for cosmological validity. We will apply observational and causality constraints to illuminate physically correct behavior of the model from the phenomenological one. We saw that an interaction between the varying Ghost DE and cold DM (CDM) also provides a solution to the cosmological coincidence problem. And we found that the Ghost DE behaves as a fluid-like matter in early Universe.

  8. A coupled hidden Markov model for disease interactions

    PubMed Central

    Sherlock, Chris; Xifara, Tatiana; Telfer, Sandra; Begon, Mike

    2013-01-01

    To investigate interactions between parasite species in a host, a population of field voles was studied longitudinally, with presence or absence of six different parasites measured repeatedly. Although trapping sessions were regular, a different set of voles was caught at each session, leading to incomplete profiles for all subjects. We use a discrete time hidden Markov model for each disease with transition probabilities dependent on covariates via a set of logistic regressions. For each disease the hidden states for each of the other diseases at a given time point form part of the covariate set for the Markov transition probabilities from that time point. This allows us to gauge the influence of each parasite species on the transition probabilities for each of the other parasite species. Inference is performed via a Gibbs sampler, which cycles through each of the diseases, first using an adaptive Metropolis–Hastings step to sample from the conditional posterior of the covariate parameters for that particular disease given the hidden states for all other diseases and then sampling from the hidden states for that disease given the parameters. We find evidence for interactions between several pairs of parasites and of an acquired immune response for two of the parasites. PMID:24223436

  9. A coupled hidden Markov model for disease interactions.

    PubMed

    Sherlock, Chris; Xifara, Tatiana; Telfer, Sandra; Begon, Mike

    2013-08-01

    To investigate interactions between parasite species in a host, a population of field voles was studied longitudinally, with presence or absence of six different parasites measured repeatedly. Although trapping sessions were regular, a different set of voles was caught at each session, leading to incomplete profiles for all subjects. We use a discrete time hidden Markov model for each disease with transition probabilities dependent on covariates via a set of logistic regressions. For each disease the hidden states for each of the other diseases at a given time point form part of the covariate set for the Markov transition probabilities from that time point. This allows us to gauge the influence of each parasite species on the transition probabilities for each of the other parasite species. Inference is performed via a Gibbs sampler, which cycles through each of the diseases, first using an adaptive Metropolis-Hastings step to sample from the conditional posterior of the covariate parameters for that particular disease given the hidden states for all other diseases and then sampling from the hidden states for that disease given the parameters. We find evidence for interactions between several pairs of parasites and of an acquired immune response for two of the parasites.

  10. PIV validation of blood-heart valve leaflet interaction modelling.

    PubMed

    Kaminsky, R; Dumont, K; Weber, H; Schroll, M; Verdonck, P

    2007-07-01

    The aim of this study was to validate the 2D computational fluid dynamics (CFD) results of a moving heart valve based on a fluid-structure interaction (FSI) algorithm with experimental measurements. Firstly, a pulsatile laminar flow through a monoleaflet valve model with a stiff leaflet was visualized by means of Particle Image Velocimetry (PIV). The inflow data sets were applied to a CFD simulation including blood-leaflet interaction. The measurement section with a fixed leaflet was enclosed into a standard mock loop in series with a Harvard Apparatus Pulsatile Blood Pump, a compliance chamber and a reservoir. Standard 2D PIV measurements were made at a frequency of 60 bpm. Average velocity magnitude results of 36 phase-locked measurements were evaluated at every 10 degrees of the pump cycle. For the CFD flow simulation, a commercially available package from Fluent Inc. was used in combination with inhouse developed FSI code based on the Arbitrary Lagrangian-Eulerian (ALE) method. Then the CFD code was applied to the leaflet to quantify the shear stress on it. Generally, the CFD results are in agreement with the PIV evaluated data in major flow regions, thereby validating the FSI simulation of a monoleaflet valve with a flexible leaflet. The applicability of the new CFD code for quantifying the shear stress on a flexible leaflet is thus demonstrated.

  11. Parallel algorithms for interactive manipulation of digital terrain models

    NASA Technical Reports Server (NTRS)

    Davis, E. W.; Mcallister, D. F.; Nagaraj, V.

    1988-01-01

    Interactive three-dimensional graphics applications, such as terrain data representation and manipulation, require extensive arithmetic processing. Massively parallel machines are attractive for this application since they offer high computational rates, and grid connected architectures provide a natural mapping for grid based terrain models. Presented here are algorithms for data movement on the massive parallel processor (MPP) in support of pan and zoom functions over large data grids. It is an extension of earlier work that demonstrated real-time performance of graphics functions on grids that were equal in size to the physical dimensions of the MPP. When the dimensions of a data grid exceed the processing array size, data is packed in the array memory. Windows of the total data grid are interactively selected for processing. Movement of packed data is needed to distribute items across the array for efficient parallel processing. Execution time for data movement was found to exceed that for arithmetic aspects of graphics functions. Performance figures are given for routines written in MPP Pascal.

  12. Simulations of Bluff Body Flow Interaction for Noise Source Modeling

    NASA Technical Reports Server (NTRS)

    Khorrami, Medi R.; Lockard David P.; Choudhari, Meelan M.; Jenkins, Luther N.; Neuhart, Dan H.; McGinley, Catherine B.

    2006-01-01

    The current study is a continuation of our effort to characterize the details of flow interaction between two cylinders in a tandem configuration. This configuration is viewed to possess many of the pertinent flow features of the highly interactive unsteady flow field associated with the main landing gear of large civil transports. The present effort extends our previous two-dimensional, unsteady, Reynolds Averaged Navier-Stokes computations to three dimensions using a quasilaminar, zonal approach, in conjunction with a two-equation turbulence model. Two distinct separation length-to-diameter ratios of L/D = 3.7 and 1.435, representing intermediate and short separation distances between the two cylinders, are simulated. The Mach 0.166 simulations are performed at a Reynolds number of Re = 1.66 105 to match the companion experiments at NASA Langley Research Center. Extensive comparisons with the measured steady and unsteady surface pressure and off-surface particle image velocimetry data show encouraging agreement. Both prominent and some of the more subtle trends in the mean and fluctuating flow fields are correctly predicted. Both computations and the measured data reveal a more robust and energetic shedding process at L/D = 3.7 in comparison with the weaker shedding in the shorter separation case of L/D = 1.435. The vortex shedding frequency based on the computed surface pressure spectra is in reasonable agreement with the measured Strouhal frequency.

  13. Computational modeling of fluid structural interaction in arterial stenosis

    NASA Astrophysics Data System (ADS)

    Bali, Leila; Boukedjane, Mouloud; Bahi, Lakhdar

    2013-12-01

    Atherosclerosis affects the arterial blood vessels causing stenosis because of which the artery hardens resulting in loss of elasticity in the affected region. In this paper, we present: an approach to model the fluid-structure interaction through such an atherosclerosis affected region of the artery, The blood is assumed as an incompressible Newtonian viscous fluid, and the vessel wall was treated as a thick-walled, incompressible and isotropic material with uniform mechanical properties. The numerical simulation has been studied in the context of The Navier-Stokes equations for an interaction with an elastic solid. The study of fluid flow and wall motion was initially carried out separately, Discretized forms of the transformed wall and flow equations, which are coupled through the boundary conditions at their interface, are obtained by control volume method and simultaneously to study the effects of wall deformability, solutions are obtained for both rigid and elastic walls. The results indicate that deformability of the wall causes an increase in the time average of pressure drop, but a decrease in the maximum wall shear stress. Displacement and stress distributions in the wall are presented.

  14. Modeling plasma plumes generated from laser solid interactions

    NASA Astrophysics Data System (ADS)

    Wilks, Scott C.; Higginson, D. P.; Link, A. J.; Park, H.-S.; Ping, Y.; Rinderknecht, H. G.; Ross, J. S.; Orban, C.; Hua, R.

    2016-10-01

    Laser pulses interacting with solid targets sitting in a vacuum form the basis for a large class of High Energy Density physics experiments. The resulting hydrodynamical evolution of the target during and after this interaction can be modeled using myriad techniques. These techniques range from pure particle-in-cell (PIC) to pure radiation-hydrodynamics, and include a large number of hybrid techniques in between. The particular method employed depends predominately on laser intensity. We compare and contrast several methods relevant for a large range of laser intensities (from Iλ2 1 ×1012W . μm2 /cm2 to Iλ2 1 ×1019W . μm2 /cm2) and energies (from E 100 mJ to E 100 kJ .) Density, temperature, and velocity profiles are benchmarked against recent experimental data. These experimental data include proton radiographs, time resolved x-ray images, and neutron yield and spectra. Methods to self-consistently handle backscatter and detailed energy deposition will also be discussed. LLNL-ABS-697767. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  15. Probing contact interactions at high energy lepton colliders

    SciTech Connect

    Cheung, K.; Godfrey, S.; Hewett, J.A.

    1996-12-01

    Fermion compositeness and other new physics can be signaled by the presence of a strong four-fermion contact interaction. Here the authors present a study of {ell}{ell}qq and {ell}{ell}{ell}{prime}{ell}{prime} contact interactions using the reactions: {ell}{sup +}{ell}{sup {minus}} {r_arrow} {ell}{prime}{sup +} {ell}{prime}{sup {minus}}, b{anti b}, c{anti c} at future e{sup +}e{sup {minus}} linear colliders with {radical}s = 0.5--5 TeV and {mu}{sup +}{mu}{sup {minus}} colliders with {radical}s = 0.5, 4 TeV. They find that very large compositeness scales can be probed at these machines and that the use of polarized beams can unravel their underlying helicity structure.

  16. Microwave modeling of laser plasma interactions. Final report

    SciTech Connect

    Not Available

    1983-08-01

    For a large laser fusion targets and nanosecond pulse lengths, stimulated Brillouin scattering (SBS) and self-focusing are expected to be significant problems. The goal of the contractual effort was to examine certain aspects of these physical phenomena in a wavelength regime (lambda approx.5 cm) more amenable to detailed diagnostics than that characteristic of laser fusion (lambda approx.1 micron). The effort was to include the design, fabrication and operation of a suitable experimental apparatus. In addition, collaboration with Dr. Neville Luhmann and his associates at UCLA and with Dr. Curt Randall of LLNL, on analysis and modelling of the UCLA experiments was continued. Design and fabrication of the TRW experiment is described under ''Experiment Design'' and ''Experimental Apparatus''. The design goals for the key elements of the experimental apparatus were met, but final integration and operation of the experiment was not accomplished. Some theoretical considerations on the interaction between Stimulated Brillouin Scattering and Self-Focusing are also presented.

  17. Description of Exotic Nuclei with the Interacting Boson Model

    SciTech Connect

    Boeyuekata, M.; Van Isacker, P.; Uluer, I.

    2008-11-11

    Even--even nuclei in the A{approx}100 mass region are investigated within the framework of the interacting boson model-1 (IBM-1). The study includes energy spectra and electric quadrupole transition properties of zirconium, molybdenum, ruthenium and palladium isotopes with neutron number N{>=}54. A global parametrization of the IBM-1 hamiltonian is found leading to a description of 301 collective levels in 30 nuclei with a root-mean-square deviation from the observed level energies of 119 keV. The geometric character of the nuclei can be visualized by plotting the potential energy surface V({beta},{gamma}) obtained from the IBM-1 hamiltonian in the classical limit. The parametrization established on the basis of known elements is then used to predict properties of the unknown, neutron-rich isotopes {sup 106}Zr, {sup 112}Mo, {sup 116}Ru and {sup 120}Pd.

  18. A model of hydrodynamic interaction between swimming bacteria.

    SciTech Connect

    Gyrya, V.; Aranson, I. G.; Berlyand, L. V.; Karpeev, D.; Penn State Univ.

    2010-01-01

    We study the dynamics and interaction of two swimming bacteria, modeled by self-propelled dumbbell-type structures. We focus on alignment dynamics of a coplanar pair of elongated swimmers, which propel themselves either by 'pushing' or 'pulling' both in three- and quasi-two-dimensional geometries of space. We derive asymptotic expressions for the dynamics of the pair, which complemented by numerical experiments, indicate that the tendency of bacteria to swim in or swim off depends strongly on the position of the propulsion force. In particular, we observe that positioning of the effective propulsion force inside the dumbbell results in qualitative agreement with the dynamics observed in experiments, such as mutual alignment of converging bacteria.

  19. NPLOT: an Interactive Plotting Program for NASTRAN Finite Element Models

    NASA Technical Reports Server (NTRS)

    Jones, G. K.; Mcentire, K. J.

    1985-01-01

    The NPLOT (NASTRAN Plot) is an interactive computer graphics program for plotting undeformed and deformed NASTRAN finite element models. Developed at NASA's Goddard Space Flight Center, the program provides flexible element selection and grid point, ASET and SPC degree of freedom labelling. It is easy to use and provides a combination menu and command driven user interface. NPLOT also provides very fast hidden line and haloed line algorithms. The hidden line algorithm in NPLOT proved to be both very accurate and several times faster than other existing hidden line algorithms. A fast spatial bucket sort and horizon edge computation are used to achieve this high level of performance. The hidden line and the haloed line algorithms are the primary features that make NPLOT different from other plotting programs.

  20. Modeling Gene-Environment Interactions With Quasi-Natural Experiments.

    PubMed

    Schmitz, Lauren; Conley, Dalton

    2017-02-01

    This overview develops new empirical models that can effectively document Gene × Environment (G×E) interactions in observational data. Current G×E studies are often unable to support causal inference because they use endogenous measures of the environment or fail to adequately address the nonrandom distribution of genes across environments, confounding estimates. Comprehensive measures of genetic variation are incorporated into quasi-natural experimental designs to exploit exogenous environmental shocks or isolate variation in environmental exposure to avoid potential confounders. In addition, we offer insights from population genetics that improve upon extant approaches to address problems from population stratification. Together, these tools offer a powerful way forward for G×E research on the origin and development of social inequality across the life course.

  1. Triviality of a model of particles with point interactions in the thermodynamic limit

    NASA Astrophysics Data System (ADS)

    Moser, Thomas; Seiringer, Robert

    2016-11-01

    We consider a model of fermions interacting via point interactions, defined via a certain weighted Dirichlet form. While for two particles the interaction corresponds to infinite scattering length, the presence of further particles effectively decreases the interaction strength. We show that the model becomes trivial in the thermodynamic limit, in the sense that the free energy density at any given particle density and temperature agrees with the corresponding expression for non-interacting particles.

  2. Application of Core Dynamics Modeling to Core-Mantle Interactions

    NASA Technical Reports Server (NTRS)

    Kuang, Weijia

    2003-01-01

    Observations have demonstrated that length of day (LOD) variation on decadal time scales results from exchange of axial angular momentum between the solid mantle and the core. There are in general four core-mantle interaction mechanisms that couple the core and the mantle. Of which, three have been suggested likely the dominant coupling mechanism for the decadal core-mantle angular momentum exchange, namely, gravitational core-mantle coupling arising from density anomalies in the mantle and in the core (including the inner core), the electromagnetic coupling arising from Lorentz force in the electrically conducting lower mantle (e.g. D-layer), and the topographic coupling arising from non-hydrostatic pressure acting on the core-mantle boundary (CMB) topography. In the past decades, most effort has been on estimating the coupling torques from surface geomagnetic observations (kinematic approach), which has provided insights on the core dynamical processes. In the meantime, it also creates questions and concerns on approximations in the studies that may invalidate the corresponding conclusions. The most serious problem is perhaps the approximations that are inconsistent with dynamical processes in the core, such as inconsistencies between the core surface flow beneath the CMB and the CMB topography, and that between the D-layer electric conductivity and the approximations on toroidal field at the CMB. These inconsistencies can only be addressed with numerical core dynamics modeling. In the past few years, we applied our MoSST (Modular, Scalable, Self-consistent and Three-dimensional) core dynamics model to study core-mantle interactions together with geodynamo simulation, aiming at assessing the effect of the dynamical inconsistencies in the kinematic studies on core-mantle coupling torques. We focus on topographic and electromagnetic core-mantle couplings and find that, for the topographic coupling, the consistency between the core flow and the CMB topography is

  3. Models of interacting supernovae and their spectral diversity

    NASA Astrophysics Data System (ADS)

    Dessart, Luc; Hillier, D. John; Audit, Edouard; Livne, Eli; Waldman, Roni

    2016-05-01

    Using radiation hydrodynamics and radiative transfer simulations, we explore the origin of the spectral diversity of interacting supernovae (SNe) of Type IIn. We revisit SN 1994W and investigate the dynamical configurations that can give rise to spectra with narrow lines at all times. We find that a standard ˜10 M⊙ 1051 erg SN ejecta ramming into a 0.4 M⊙ dense circumstellar material is inadequate for SN 1994W, as it leads to the appearance of broad lines at late times. This structure, however, generates spectra that exhibit the key morphological changes seen in SN 1998S. For SN 1994W, we consider a completely different configuration, which involves the interaction at a large radius of a low-mass inner shell with a high-mass outer shell. Such a structure may arise in an 8-12 M⊙ star from a nuclear flash (e.g. of Ne) followed within a few years by core collapse. Our simulations show that the large mass of the outer shell leads to the complete braking of the inner shell material, the formation of a slow dense shell, and the powering of a luminous SN IIn, even for a low inner shell energy. Early on, our model line profiles are typical of SNe IIn, exhibiting narrow cores and broad electron-scattering wings. As observed in SN 1994W, they also remain narrow at late times. Our SN 1994W model invokes two low-energy ejections, both atypical of observed massive stars, and illustrates the diversity of configurations leading to SNe IIn. These results also highlight the importance of spectra to constrain the dynamical properties and understand the origin of SNe IIn.

  4. a Global Model for Long-Range Interaction `DAMPING Functions'

    NASA Astrophysics Data System (ADS)

    Myatt, Philip Thomas; McCourt, Frederick R. W.; Le Roy, Robert J.

    2016-06-01

    In recent years, `damping functions', which characterize the weakening of inverse-power-sum long-range interatomic interaction energies with increasing electron overlap, have become an increasing important component of models for diatomic molecule interaction potentials. However, a key feature of models for damping functions, their portability, has received little scrutiny. The present work set out to examine all available ab initio induction and dispersion damping function data and to attempt to devise a `global' scheme for diatomic molecule damping functions. It appears that while neutral (H, He, Li, and Ne, homonuclear and mixed) and anion (H^- with H, He and Li) species obey (approximately) one common rule, proton plus neutral (H^+ with H, He and Li) and non-proton-cation plus neutral systems (He^+ and Li^+ with H, He and Li), must each be treated separately. However, for all three cases, a version of the Douketis-Scoles-Thakkar (ionization potential)power factor is a key scaling parameter. R.J. Le Roy, C. C. Haugen, J. Tao and Hui Li, Mol. Phys. 109,435 (2011). P.J. Knowles and W.J. Meath,J. Mol. Phys. 60, 1143 (1987); R.J. Wheatley and W.J. Meath,J. Mol. Phys. 80, 25 (1993); R.J. Wheatley and W.J. Meath J. Chem. Phys. 179, 341 (1994); R.J. Wheatley and W.J. Meath,J. Chem. Phys. 203, 209 (1996). C. Douketis,G. Scoles, S. Marchetti, M. Zen and A. J. Thakkar, J. Chem. Phys. 76, 3057 (1982).

  5. The display of molecular models with the Ames Interactive Modeling System (AIMS)

    NASA Technical Reports Server (NTRS)

    Egan, J. T.; Hart, J.; Burt, S. K.; Macelroy, R. D.

    1982-01-01

    A visualization of molecular models can lead to a clearer understanding of the models. Sophisticated graphics devices supported by minicomputers make it possible for the chemist to interact with the display of a very large model, altering its structure. In addition to user interaction, the need arises also for other ways of displaying information. These include the production of viewgraphs, film presentation, as well as publication quality prints of various models. To satisfy these needs, the display capability of the Ames Interactive Modeling System (AIMS) has been enhanced to provide a wide range of graphics and plotting capabilities. Attention is given to an overview of the AIMS system, graphics hardware used by the AIMS display subsystem, a comparison of graphics hardware, the representation of molecular models, graphics software used by the AIMS display subsystem, the display of a model obtained from data stored in molecule data base, a graphics feature for obtaining single frame permanent copy displays, and a feature for producing multiple frame displays.

  6. Probabilistic Multi-Factor Interaction Model for Complex Material Behavior

    NASA Technical Reports Server (NTRS)

    Abumeri, Galib H.; Chamis, Christos C.

    2010-01-01

    Complex material behavior is represented by a single equation of product form to account for interaction among the various factors. The factors are selected by the physics of the problem and the environment that the model is to represent. For example, different factors will be required for each to represent temperature, moisture, erosion, corrosion, etc. It is important that the equation represent the physics of the behavior in its entirety accurately. The Multi-Factor Interaction Model (MFIM) is used to evaluate the divot weight (foam weight ejected) from the external launch tanks. The multi-factor has sufficient degrees of freedom to evaluate a large number of factors that may contribute to the divot ejection. It also accommodates all interactions by its product form. Each factor has an exponent that satisfies only two points - the initial and final points. The exponent describes a monotonic path from the initial condition to the final. The exponent values are selected so that the described path makes sense in the absence of experimental data. In the present investigation, the data used were obtained by testing simulated specimens in launching conditions. Results show that the MFIM is an effective method of describing the divot weight ejected under the conditions investigated. The problem lies in how to represent the divot weight with a single equation. A unique solution to this problem is a multi-factor equation of product form. Each factor is of the following form (1 xi/xf)ei, where xi is the initial value, usually at ambient conditions, xf the final value, and ei the exponent that makes the curve represented unimodal that meets the initial and final values. The exponents are either evaluated by test data or by technical judgment. A minor disadvantage may be the selection of exponents in the absence of any empirical data. This form has been used successfully in describing the foam ejected in simulated space environmental conditions. Seven factors were required

  7. Models of Yukawa interaction in the two Higgs doublet model, and their collider phenomenology

    SciTech Connect

    Aoki, Mayumi; Kanemura, Shinya; Yagyu, Kei; Tsumura, Koji

    2009-07-01

    Possible models of Yukawa interaction are discussed in the two Higgs doublet model (THDM) under the discrete symmetry imposed to avoid the flavor changing neutral current at the leading order. It is known that there are four types of such models corresponding to the possible different assignment of charges for the discrete symmetry on quarks and leptons. We first examine the decay properties of Higgs bosons in each type model, and summarize constraints on the models from current experimental data. We then shed light on the differences among these models in collider phenomenology. In particular, we mainly discuss the so-called type-II THDM and type-X THDM. The type-II THDM corresponds to the model with the same Yukawa interaction as the minimal supersymmetric standard model. On the other hand, in the type-X THDM, additional Higgs bosons can predominantly decay into leptons. This scenario may be interesting because of the motivation for a light charged Higgs boson scenario such as in the TeV-scale model of neutrinos, dark matter, and baryogenesis. We study how we can distinguish the type-X THDM from the minimal supersymmetric standard model at the Large Hadron Collider and the International Linear Collider.

  8. Flow interaction experiment. Volume 1: Aerothermal modeling, phase 2

    NASA Technical Reports Server (NTRS)

    Nikjooy, M.; Mongia, H. C.; Sullivan, J. P.; Murthy, S. N. B.

    1993-01-01

    An experimental and computational study is reported for the flow of a turbulent jet discharging into a rectangular enclosure. The experimental configurations consisting of primary jets only, annular jets only, and a combination of annular and primary jets are investigated to provide a better understanding of the flow field in an annular combustor. A laser Doppler velocimeter is used to measure mean velocity and Reynolds stress components. Major features of the flow field include recirculation, primary and annular jet interaction, and high turbulence. A significant result from this study is the effect the primary jets have on the flow field. The primary jets are seen to create statistically larger recirculation zones and higher turbulence levels. In addition, a technique called marker nephelometry is used to provide mean concentration values in the model combustor. Computations are performed using three levels of turbulence closures, namely k-epsilon model, algebraic second moment (ASM), and differential second moment (DSM) closure. Two different numerical schemes are applied. One is the lower-order power-law differencing scheme (PLDS) and the other is the higher-order flux-spline differencing scheme (FSDS). A comparison is made of the performance of these schemes. The numerical results are compared with experimental data. For the cases considered in this study, the FSDS is more accurate than the PLDS. For a prescribed accuracy, the flux-spline scheme requires a far fewer number of grid points. Thus, it has the potential for providing a numerical error-free solution, especially for three-dimensional flows, without requiring an excessively fine grid. Although qualitatively good comparison with data was obtained, the deficiencies regarding the modeled dissipation rate (epsilon) equation, pressure-strain correlation model, and the inlet epsilon profile and other critical closure issues need to be resolved before one can achieve the degree of accuracy required to

  9. Flow interaction experiment. Volume 2: Aerothermal modeling, phase 2

    NASA Technical Reports Server (NTRS)

    Nikjooy, M.; Mongia, H. C.; Sullivan, J. P.; Murthy, S. N. B.

    1993-01-01

    An experimental and computational study is reported for the flow of a turbulent jet discharging into a rectangular enclosure. The experimental configurations consisting of primary jets only, annular jets only, and a combination of annular and primary jets are investigated to provide a better understanding of the flow field in an annular combustor. A laser Doppler velocimeter is used to measure mean velocity and Reynolds stress components. Major features of the flow field include recirculation, primary and annular jet interaction, and high turbulence. A significant result from this study is the effect the primary jets have on the flow field. The primary jets are seen to create statistically larger recirculation zones and higher turbulence levels. In addition, a technique called marker nephelometry is used to provide mean concentration values in the model combustor. Computations are performed using three levels of turbulence closures, namely k-epsilon model, algebraic second moment (ASM), and differential second moment (DSM) closure. Two different numerical schemes are applied. One is the lower-order power-law differencing scheme (PLDS) and the other is the higher-order flux-spline differencing scheme (FSDS). A comparison is made of the performance of these schemes. The numerical results are compared with experimental data. For the cases considered in this study, the FSDS is more accurate than the PLDS. For a prescribed accuracy, the flux-spline scheme requires a far fewer number of grid points. Thus, it has the potential for providing a numerical error-free solution, especially for three-dimensional flows, without requiring an excessively fine grid. Although qualitatively good comparison with data was obtained, the deficiencies regarding the modeled dissipation rate (epsilon) equation, pressure-strain correlation model, and the inlet epsilon profile and other critical closure issues need to be resolved before one can achieve the degree of accuracy required to

  10. Modeling and analysis of vegetation-climate interactions using neutral networks and generalized logit models

    SciTech Connect

    Siegel, E.; Kandikar, M.; Dowlatabadi, H.

    1995-12-31

    The importance of biosphere-climate interactions for energy and moisture balances and major biogeochemical cycles is well recognized. Climate change is expected to alter the functioning and distribution of major ecosystems. These changes have been investigated using global vegetation transfer models.

  11. Cascading and feedback in interactive models of production: a reflection of forward modeling?

    PubMed

    Dell, Gary S

    2013-08-01

    Interactive theories of lexical retrieval in language production assume that activation cascades from earlier to later processing levels, and feeds back in the reverse direction. This commentary invites Pickering & Garrod (P&G) to consider whether cascading and feedback can be seen as a form of forwarding modeling within a hierarchical production system.

  12. Evaluating Frugivore-fruit Interactions Using Avian Eye Modelling

    PubMed Central

    Fadzly, Nik; Burns, Kevin C.; Zuharah, Wan Fatma

    2013-01-01

    Fruit phenotypes are often hypothesised to be affected by selection by frugivores. Here, we tested two hypotheses concerning frugivore-fruit interactions from the perspective of fruit colours. We measured the spectral properties of 26 fruits and the associated leaves of plants from 2 islands in New Zealand. Visual observations were also performed to record the birds that fed on the fruits. First, we tested the fruit-foliage hypothesis, where fruit colours are assumed to be evolutionarily constrained by their own leaf colour to maximise colour contrast and fruit conspicuousness. We ran a null model analysis comparing fruit colour contrast using an avian eye model. Second, we tested the frugivore specificity hypothesis, where specific fruit colours are thought to be connected with a specific bird frugivore. We performed a regression on the number of bird visits against the fruit colour in tetrahedral colour space based on an avian eye calculation using Mantel’s test. The results show that fruit colours are not constrained by their own leaf colours. There is also no relationship or pattern suggesting a link between a specific fruit colour and specific bird visitors. We suggest that although fruit colour is one of the most highly discussed components, it is not the most important single deciding factor in frugivore fruit selection. PMID:24575247

  13. Microscopic formulation of the interacting boson model for rotational nuclei

    SciTech Connect

    Nomura, Kosuke; Shimizu, Noritaka; Otsuka, Takaharu; Guo, Lu

    2011-04-15

    We propose a novel formulation of the interacting boson model (IBM) for rotational nuclei with axially symmetric, strong deformation. The intrinsic structure represented by the potential-energy surface (PES) of a given multinucleon system has a certain similarity to that of the corresponding multiboson system. Based on this feature, one can derive an appropriate boson Hamiltonian, as already reported. This prescription, however, has a major difficulty in the rotational spectra of strongly deformed nuclei: the bosonic moment of inertia is significantly smaller than the corresponding nucleonic one. We present that this difficulty originates in the difference between the rotational response of a nucleon system and that of the corresponding boson system, and could arise even if the PESs of the two systems were identical. We further suggest that the problem can be solved by implementing the L{center_dot}L term into the IBM Hamiltonian, with the coupling constant derived from the cranking approach of Skyrme mean-field models. The validity of the method is confirmed for rare-earth and actinoid nuclei, as their experimental rotational yrast bands are reproduced nicely.

  14. Quantitative Model of microRNA-mRNA interaction

    NASA Astrophysics Data System (ADS)

    Noorbakhsh, Javad; Lang, Alex; Mehta, Pankaj

    2012-02-01

    MicroRNAs are short RNA sequences that regulate gene expression and protein translation by binding to mRNA. Experimental data reveals the existence of a threshold linear output of protein based on the expression level of microRNA. To understand this behavior, we propose a mathematical model of the chemical kinetics of the interaction between mRNA and microRNA. Using this model we have been able to quantify the threshold linear behavior. Furthermore, we have studied the effect of internal noise, showing the existence of an intermediary regime where the expression level of mRNA and microRNA has the same order of magnitude. In this crossover regime the mRNA translation becomes sensitive to small changes in the level of microRNA, resulting in large fluctuations in protein levels. Our work shows that chemical kinetics parameters can be quantified by studying protein fluctuations. In the future, studying protein levels and their fluctuations can provide a powerful tool to study the competing endogenous RNA hypothesis (ceRNA), in which mRNA crosstalk occurs due to competition over a limited pool of microRNAs.

  15. Rheology of colloidal microphases in a model with competing interactions.

    PubMed

    Imperio, Alessandra; Reatto, Luciano; Zapperi, Stefano

    2008-08-01

    We study the rheological properties of colloidal microphases in two dimensions simulating a model of colloidal particles with competing interactions. Due to the competition between short-range attraction and long-range repulsion, as a function of the density the model exhibits a variety of microphases such as clusters, stripes, or crystals with bubbles. We prepare the system in a confined microphase employing Monte Carlo simulations and then shear the resulting configurations by applying a drag force profile. We integrate numerically the equation of motion for the particles and analyze the dynamics as a function of the density and the applied strain rate. We measure the stress-strain curves and characterize the yielding of the colloidal microphases. The results depend on the type of microphase. (i) Clusters are easily sheared along layers and the relative motion is assisted by rotations. (ii) Stripes shear easily when they are parallel to the flow and tend to jam when they are perpendicular to it. Under a sufficiently strong shear rate perpendicular stripes orient in the flow direction. (iii) Crystals with bubbles yield by fracturing along the bubbles and eventually forming stripes. We discuss the role of dislocations, emitted by the bubbles, in the yielding process. Finally, we analyze the effect of thermal fluctuations on the rheological properties.

  16. Improved Full Configuration Interaction Monte Carlo for the Hubbard Model

    NASA Astrophysics Data System (ADS)

    Changlani, Hitesh; Holmes, Adam; Petruzielo, Frank; Chan, Garnet; Henley, C. L.; Umrigar, C. J.

    2012-02-01

    We consider the recently proposed full configuration interaction quantum Monte Carlo (FCI-QMC) method and its ``initiator'' extension, both of which promise to ameliorate the sign problem by utilizing the cancellation of positive and negative walkers in the Hilbert space of Slater determinants. While the method has been primarily used for quantum chemistry by A.Alavi and his co-workers [1,2], its application to lattice models in solid state physics has not been tested. We propose an improvement in the form of choosing a basis to make the wavefunction more localized in Fock space, which potentially also reduces the sign problem. We perform calculations on the 4x4 and 8x8 Hubbard models in real and momentum space and in a basis motivated by the reduced density matrix of a 2x2 real space patch obtained from the exact diagonalization of a larger system in which it is embedded. We discuss our results for a range of fillings and U/t and compare them with previous Auxiliary Field QMC and Fixed Node Green's Function Monte Carlo calculations. [4pt] [1] George Booth, Alex Thom, Ali Alavi, J Chem Phys, 131, 050106,(2009)[0pt] [2] D Cleland, GH Booth, Ali Alavi, J Chem Phys 132, 041103, (2010)

  17. Modeling the Interaction of Europa with the Jovian Magnetosphere

    NASA Astrophysics Data System (ADS)

    Rubin, M.; Combi, M. R.; Daldorff, L.; Gombosi, T. I.; Hansen, K. C.; Jia, X.; Kivelson, M. G.; Tenishev, V.

    2011-12-01

    The interaction of Jupiter's corotating magnetosphere with Europa's subsurface water ocean is responsible for the observed induced dipolar magnetic field. Furthermore the pick-up process of newly ionized particles from Europa's neutral atmosphere alters the magnetic and electric field topology around the moon. We use the Block-Adaptive-Tree-Solarwind-Roe-Upwind-Scheme (BATS-R-US) of the Space Weather Modeling Framework (SWMF) to model the interaction of Europa with the Jovian magnetosphere. The BATS-R-US code solves the governing equations of magnetohydrodynamics (MHD) in a fully 3D adaptive mesh. In our approach we solve the equations for one single ion species, starting from the work by Kabin et al. (J. Geophys. Res., 104, A9, 19983-19992, 1999) accounting for the exospheric mass loading, ion-neutral charge exchange, and ion-electron recombination. We continue by separately solving the electron pressure equation and furthermore extend the magnetic induction equation by the resistive and Hall terms. The resistive term accounts for the finite electron diffusivity and thus allows a more adequate description of the effect of magnetic diffusion due to collisions [Ledvina et al., Sp. Sci. Rev., 139:143-189, 2008]. For this purpose we use ion-electron and electron-neutral collision rates presented by Schunk and Nagy (Ionospheres, Cambridge University Press, 2000). The Hall term allows ions and electrons to move at different velocities while the magnetic field remains frozen to the electrons. The assumed charge neutrality of the ion-electron plasma is maintained everywhere at all times. The model is run at different phases of Jupiter's rotation reflecting the different locations of Europa with respect to the center of the plasma sheet and is compared to measurements obtained by the Galileo magnetometer [Kivelson et al., J. Geophys. Res., 104:4609-4626, 1999]. The resulting influence on the induced magnetic dipolar field is studied and compared to the results from the

  18. Modeling Wave-Ice Interactions in the Marginal Ice Zone

    NASA Astrophysics Data System (ADS)

    Orzech, Mark; Shi, Fengyan; Bateman, Sam; Veeramony, Jay; Calantoni, Joe

    2015-04-01

    The small-scale (O(m)) interactions between waves and ice floes in the marginal ice zone (MIZ) are investigated with a coupled model system. Waves are simulated with the non-hydrostatic finite-volume model NHWAVE (Ma et al., 2012) and ice floes are represented as bonded collections of smaller particles with the discrete element system LIGGGHTS (Kloss et al., 2012). The physics of fluid and ice are recreated as authentically as possible, to allow the coupled system to supplement and/or substitute for more costly and demanding field experiments. The presentation will first describe the development and validation of the coupled system, then discuss the results of a series of virtual experiments in which ice floe and wave characteristics are varied to examine their effects on energy dissipation, MIZ floe size distribution, and ice pack retreat rates. Although Wadhams et al. (1986) suggest that only a small portion (roughly 10%) of wave energy entering the MIZ is reflected, dissipation mechanisms for the remaining energy have yet to be delineated or measured. The virtual experiments are designed to focus on specific properties and processes - such as floe size and shape, collision and fracturing events, and variations in wave climate - and measure their relative roles the transfer of energy and momentum from waves to ice. Questions to be examined include: How is energy dissipated by ice floe collisions, fracturing, and drag, and how significant is the wave attenuation associated with each process? Do specific wave/floe length scale ratios cause greater wave attenuation? How does ice material strength affect the rate of wave energy loss? The coupled system will ultimately be used to test and improve upon wave-ice parameterizations for large-scale climate models. References: >Kloss, C., C. Goniva, A. Hager, S. Amberger, and S. Pirker (2012). Models, algorithms and validation for opensource DEM and CFD-DEM. Progress in Computational Fluid Dynamics 12(2/3), 140-152. >Ma, G

  19. How Levels of Interactivity in Tutorials Affect Students' Learning of Modeling Transportation Problems in a Spreadsheet

    ERIC Educational Resources Information Center

    Seal, Kala Chand; Przasnyski, Zbigniew H.; Leon, Linda A.

    2010-01-01

    Do students learn to model OR/MS problems better by using computer-based interactive tutorials and, if so, does increased interactivity in the tutorials lead to better learning? In order to determine the effect of different levels of interactivity on student learning, we used screen capture technology to design interactive support materials for…

  20. Pattern formation through spatial interactions in a modified Daisyworld model

    NASA Astrophysics Data System (ADS)

    Alberti, Tommaso; Primavera, Leonardo; Lepreti, Fabio; Vecchio, Antonio; Carbone, Vincenzo

    2015-04-01

    The Daisyworld model is based on a hypothetical planet, like the Earth, which receives the radiant energy coming from a Sun-like star, and populated by two kinds of identical plants differing by their colour: white daisies reflecting light and black daisies absorbing light. The interactions and feedbacks between the collective biota of the planet and the incoming radiation form a self-regulating system where the conditions for life are maintained. We investigate a modified version of the Daisyworld model where a spatial dependency on latitude is introduced, and both a variable heat diffusivity along latitude and a simple greenhouse model are included. We show that the spatial interactions between the variables of the system can generate some equilibrium patterns which can locally stabilize the coexistence of the two vegetation types. The feedback on albedo is able to generate new equilibrium solutions which can efficiently self-regulate the planet climate, even for values of the solar luminosity relatively far from the current Earth conditions. The extension to spatial Daisyworld gives room to the possibility of inhomogeneous solar forcing in a curved planet, with explicit differences between poles and equator and the direct use of the heat diffusion equation. As a first approach, to describe a spherical planet, we consider the temperature T(θ,t) and the surface coverage as depending only on time and on latitude θ (-90° ≤ θ ≤ 90°). A second step is the introduction of the greenhouse effect in the model, the process by which outgoing infrared radiation is partly screened by greenhouse gases. This effect can be described by relaxing the black-body radiation hypothesis and by introducing a grayness function g(T) in the heat equation. As a third step, we consider a latitude dependence of the Earth's conductivity, χ = χ(θ). Considering these terms, using spherical coordinates and symmetry with respect to θ, the modified Daisyworld equations reduce to the

  1. Molecular Interaction between Magainin 2 and Model Membranes in Situ

    PubMed Central

    Nguyen, Khoi; Le Clair, Stéphanie V.; Ye, Shuji; Chen, Zhan

    2009-01-01

    In this paper, we investigated the molecular interactions of Magainin 2 with model cell membranes using Sum Frequency Generation (SFG) vibrational spectroscopy and Attenuated Total Reflectance – Fourier Transform Infrared spectroscopy (ATR-FTIR). Symmetric 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (POPG) and 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphocholine (POPC) bilayers, which model the bacterial and mammalian cell membranes respectively, were used in the studies. It was observed by SFG that Magainin 2 orients relatively parallel to the POPG lipid bilayer surface at low solution concentrations, around 200 nM. When increasing the Magainin 2 concentration to 800 nM, both SFG and ATR-FTIR results indicate that Magainin 2 molecules insert into the POPG bilayer and adopt a transmembrane orientation with an angle of about 20 degrees from the POPG bilayer normal. For the POPC bilayer, even at a much higher peptide concentration of 2.0 µM, no ATR-FTIR signal was detected. For this concentration on POPC, SFG studies indicated that Magainin 2 molecules adopt an orientation nearly parallel to the bilayer surface, with an orientation angle of 75 degrees from the surface normal. This shows that SFG has a much better detection limit than ATR-FTIR and can therefore be applied to study interfacial molecules with much lower surface coverage. This Magainin 2 orientation study and further investigation of the lipid bilayer SFG signals support the proposed toroidal pore model for the antimicrobial activity of Magainin 2. PMID:19728722

  2. Modelling the fear effect in predator-prey interactions.

    PubMed

    Wang, Xiaoying; Zanette, Liana; Zou, Xingfu

    2016-11-01

    A recent field manipulation on a terrestrial vertebrate showed that the fear of predators alone altered anti-predator defences to such an extent that it greatly reduced the reproduction of prey. Because fear can evidently affect the populations of terrestrial vertebrates, we proposed a predator-prey model incorporating the cost of fear into prey reproduction. Our mathematical analyses show that high levels of fear (or equivalently strong anti-predator responses) can stabilize the predator-prey system by excluding the existence of periodic solutions. However, relatively low levels of fear can induce multiple limit cycles via subcritical Hopf bifurcations, leading to a bi-stability phenomenon. Compared to classic predator-prey models which ignore the cost of fear where Hopf bifurcations are typically supercritical, Hopf bifurcations in our model can be both supercritical and subcritical by choosing different sets of parameters. We conducted numerical simulations to explore the relationships between fear effects and other biologically related parameters (e.g. birth/death rate of adult prey), which further demonstrate the impact that fear can have in predator-prey interactions. For example, we found that under the conditions of a Hopf bifurcation, an increase in the level of fear may alter the direction of Hopf bifurcation from supercritical to subcritical when the birth rate of prey increases accordingly. Our simulations also show that the prey is less sensitive in perceiving predation risk with increasing birth rate of prey or increasing death rate of predators, but demonstrate that animals will mount stronger anti-predator defences as the attack rate of predators increases.

  3. Assessing Spurious Interaction Effects in Structural Equation Modeling

    ERIC Educational Resources Information Center

    Harring, Jeffrey R.; Weiss, Brandi A.; Li, Ming

    2015-01-01

    Several studies have stressed the importance of simultaneously estimating interaction and quadratic effects in multiple regression analyses, even if theory only suggests an interaction effect should be present. Specifically, past studies suggested that failing to simultaneously include quadratic effects when testing for interaction effects could…

  4. Interactive 4D Visualization of Sediment Transport Models

    NASA Astrophysics Data System (ADS)

    Butkiewicz, T.; Englert, C. M.

    2013-12-01

    Coastal sediment transport models simulate the effects that waves, currents, and tides have on near-shore bathymetry and features such as beaches and barrier islands. Understanding these dynamic processes is integral to the study of coastline stability, beach erosion, and environmental contamination. Furthermore, analyzing the results of these simulations is a critical task in the design, placement, and engineering of coastal structures such as seawalls, jetties, support pilings for wind turbines, etc. Despite the importance of these models, there is a lack of available visualization software that allows users to explore and perform analysis on these datasets in an intuitive and effective manner. Existing visualization interfaces for these datasets often present only one variable at a time, using two dimensional plan or cross-sectional views. These visual restrictions limit the ability to observe the contents in the proper overall context, both in spatial and multi-dimensional terms. To improve upon these limitations, we use 3D rendering and particle system based illustration techniques to show water column/flow data across all depths simultaneously. We can also encode multiple variables across different perceptual channels (color, texture, motion, etc.) to enrich surfaces with multi-dimensional information. Interactive tools are provided, which can be used to explore the dataset and find regions-of-interest for further investigation. Our visualization package provides an intuitive 4D (3D, time-varying) visualization of sediment transport model output. In addition, we are also integrating real world observations with the simulated data to support analysis of the impact from major sediment transport events. In particular, we have been focusing on the effects of Superstorm Sandy on the Redbird Artificial Reef Site, offshore of Delaware Bay. Based on our pre- and post-storm high-resolution sonar surveys, there has significant scour and bedform migration around the

  5. Monte Carlo Study of One-Dimensional Ising Models with Long-Range Interactions

    NASA Astrophysics Data System (ADS)

    Tomita, Yusuke

    2009-01-01

    Recently, Fukui and Todo have proposed a new effective Monte Carlo algorithm for long-range interacting systems. Using the algorithm with the nonequilibrium relaxation method, we investigated long-range interacting one-dimensional Ising models both ferromagnetic and antiferromagnetic with the nearest-neighbor ferromagnetic interaction. For the antiferromagnetic model, we found the systems are paramagnetic at finite temperatures.

  6. Learning with Interactive Whiteboards: Determining the Factors on Promoting Interactive Whiteboards to Students by Technology Acceptance Model

    ERIC Educational Resources Information Center

    Kilic, Eylem; Güler, Çetin; Çelik, H. Eray; Tatli, Cemal

    2015-01-01

    Purpose: The purpose of this study is to investigate the factors which might affect the intention to use interactive whiteboards (IWBs) by university students, using Technology Acceptance Model by the structural equation modeling approach. The following hypothesis guided the current study: H1. There is a positive relationship between IWB…

  7. COTHERM: Modelling fluid-rock interactions in Icelandic geothermal systems

    NASA Astrophysics Data System (ADS)

    Thien, Bruno; Kosakowski, Georg; Kulik, Dmitrii

    2014-05-01

    field by Gudmundsson & Arnorsson [3] and by Icelandic partners of the COTHERM project suggests that the concept of partial equilibrium with instantaneous precipitation of secondary minerals is not sufficient to satisfactorily describe the experimental data. Considering kinetic controls also for secondary minerals appears as indispensable to properly describe the geothermal system evolution using a reactive transport modelling approach [4]. [1] Kulik D.A., Wagner T., Dmytrieva S.V., Kosakowski G., Hingerl F.F., Chudnenko K.V., Berner U., 2013. GEM-Selektor geochemical modeling package: revised algorithm and GEMS3K numerical kernel for coupled simulation codes. Computational Geosciences 17, 1-24. http://gems.web.psi.ch. [2] Palandri, J.L., Kharaka, Y.K., 2004. A compilation of rate parameters of water-mineral interaction kinetics for application to geochemical modelling. U.S.Geological Survey, Menlo Park, CA, pp. 1-64. [3] Gudmundsson B.T., Arnorsson S., 2005. Secondary mineral-fluid equilibria in the Krafla and Namafjall geothermal systems, Iceland. Applied Geochememistry 20, 1607-1625. [4] Kosakowski, G., & Watanabe, N., 2013. OpenGeoSys-Gem: A numerical tool for calculating geochemical and porosity changes in saturated and partially saturated media. Physics and Chemistry of the Earth, Parts A/B/C. doi:10.1016/j.pce.2013.11.008

  8. Modelling interactions of toxicants and density dependence in wildlife populations

    USGS Publications Warehouse

    Schipper, Aafke M.; Hendriks, Harrie W.M.; Kauffman, Matthew J.; Hendriks, A. Jan; Huijbregts, Mark A.J.

    2013-01-01

    1. A major challenge in the conservation of threatened and endangered species is to predict population decline and design appropriate recovery measures. However, anthropogenic impacts on wildlife populations are notoriously difficult to predict due to potentially nonlinear responses and interactions with natural ecological processes like density dependence. 2. Here, we incorporated both density dependence and anthropogenic stressors in a stage-based matrix population model and parameterized it for a density-dependent population of peregrine falcons Falco peregrinus exposed to two anthropogenic toxicants [dichlorodiphenyldichloroethylene (DDE) and polybrominated diphenyl ethers (PBDEs)]. Log-logistic exposure–response relationships were used to translate toxicant concentrations in peregrine falcon eggs to effects on fecundity. Density dependence was modelled as the probability of a nonbreeding bird acquiring a breeding territory as a function of the current number of breeders. 3. The equilibrium size of the population, as represented by the number of breeders, responded nonlinearly to increasing toxicant concentrations, showing a gradual decrease followed by a relatively steep decline. Initially, toxicant-induced reductions in population size were mitigated by an alleviation of the density limitation, that is, an increasing probability of territory acquisition. Once population density was no longer limiting, the toxicant impacts were no longer buffered by an increasing proportion of nonbreeders shifting to the breeding stage, resulting in a strong decrease in the equilibrium number of breeders. 4. Median critical exposure concentrations, that is, median toxicant concentrations in eggs corresponding with an equilibrium population size of zero, were 33 and 46 μg g−1 fresh weight for DDE and PBDEs, respectively. 5. Synthesis and applications. Our modelling results showed that particular life stages of a density-limited population may be relatively insensitive to

  9. Time-Dependent Dark Energy Density and Holographic DE Model with Interaction

    NASA Astrophysics Data System (ADS)

    Saadat, H.; Saadat, A. M.

    2011-05-01

    In this article we consider holographic dark energy model with interaction and space curvature. We calculate cosmic scale factor by using the time-dependent dark energy density. Then we obtain phenomenological interaction between holographic dark energy and matter.

  10. MODELING THE INTERACTION OF AGROCHEMICALS WITH ENVIRONMENTAL SURFACES: PESTICIDES ON RUTILE AND ORGANO-RUTILE SURFACES

    EPA Science Inventory

    Non-bonded interactions between model pesticides and organo-mineral surfaces have been studied using molecular mechanical conformational calculations and molecular dynamics simulations. The minimum energy conformations and relative binding energies for the interaction of atrazine...

  11. Fluid-structure interaction simulation of an avian flight model.

    PubMed

    Ruck, Sebastian; Oertel, Herbert

    2010-12-15

    A three-dimensional numerical avian model was developed to investigate the unsteady and turbulent aerodynamic performance of flapping wings for varying wingbeat frequencies and flow velocities (up to 12 Hz and 9 m s(-1)), corresponding to a reduced frequency range of k=0.22 to k=1.0 and a Reynolds number range of Re=16,000 to Re=50,000. The wings of the bird-inspired model consist of an elastic membrane. Simplifying the complicated locomotion kinematics to a sinusoidal wing rotation about two axes, the main features of dynamic avian flight were approximated. Numerical simulation techniques of fluid-structure interaction (FSI) providing a fully resolved flow field were applied to calculate the aerodynamic performance of the flapping elastic wings with the Reynolds averaged Navier-Stokes (RANS) approach. The results were used to characterize and describe the macroscopic flow configurations in terms of starting, stopping, trailing and bound vortices. For high reduced frequencies up to k=0.67 it was shown that the wake does not consist of individual vortex rings known as the discrete vortex ring gait. Rather, the wake is dominated by a chain of elliptical vortex rings on each wing. The structures are interlocked at the starting and stopping vortices, which are shed in pairs at the reversal points of the wingbeat cycle. For decreasing reduced frequency, the results indicate a transition to a continuous vortex gait. The upstroke becomes more aerodynamically active, leading to a consistent circulation of the bound vortex on the wing and a continuous spanwise shedding of small scale vortices. The formation of the vortices shed spanwise in pairs at the reversal points is reduced and the wake is dominated by the tip and root vortices, which form long drawn-out vortex structures.

  12. Biotic Interactions in the Face of Climate Change: A Comparison of Three Modelling Approaches

    PubMed Central

    Jaeschke, Anja; Bittner, Torsten; Jentsch, Anke; Reineking, Björn; Schlumprecht, Helmut; Beierkuhnlein, Carl

    2012-01-01

    Climate change is expected to alter biotic interactions, and may lead to temporal and spatial mismatches of interacting species. Although the importance of interactions for climate change risk assessments is increasingly acknowledged in observational and experimental studies, biotic interactions are still rarely incorporated in species distribution models. We assessed the potential impacts of climate change on the obligate interaction between Aeshna viridis and its egg-laying plant Stratiotes aloides in Europe, based on an ensemble modelling technique. We compared three different approaches for incorporating biotic interactions in distribution models: (1) We separately modelled each species based on climatic information, and intersected the future range overlap (‘overlap approach’). (2) We modelled the potential future distribution of A. viridis with the projected occurrence probability of S. aloides as further predictor in addition to climate (‘explanatory variable approach’). (3) We calibrated the model of A. viridis in the current range of S. aloides and multiplied the future occurrence probabilities of both species (‘reference area approach’). Subsequently, all approaches were compared to a single species model of A. viridis without interactions. All approaches projected a range expansion for A. viridis. Model performance on test data and amount of range gain differed depending on the biotic interaction approach. All interaction approaches yielded lower range gains (up to 667% lower) than the model without interaction. Regarding the contribution of algorithm and approach to the overall uncertainty, the main part of explained variation stems from the modelling algorithm, and only a small part is attributed to the modelling approach. The comparison of the no-interaction model with the three interaction approaches emphasizes the importance of including obligate biotic interactions in projective species distribution modelling. We recommend the use of

  13. Optimization Model for Web Based Multimodal Interactive Simulations.

    PubMed

    Halic, Tansel; Ahn, Woojin; De, Suvranu

    2015-07-15

    This paper presents a technique for optimizing the performance of web based multimodal interactive simulations. For such applications where visual quality and the performance of simulations directly influence user experience, overloading of hardware resources may result in unsatisfactory reduction in the quality of the simulation and user satisfaction. However, optimization of simulation performance on individual hardware platforms is not practical. Hence, we present a mixed integer programming model to optimize the performance of graphical rendering and simulation performance while satisfying application specific constraints. Our approach includes three distinct phases: identification, optimization and update. In the identification phase, the computing and rendering capabilities of the client device are evaluated using an exploratory proxy code. This data is utilized in conjunction with user specified design requirements in the optimization phase to ensure best possible computational resource allocation. The optimum solution is used for rendering (e.g. texture size, canvas resolution) and simulation parameters (e.g. simulation domain) in the update phase. Test results are presented on multiple hardware platforms with diverse computing and graphics capabilities to demonstrate the effectiveness of our approach.

  14. Optimization Model for Web Based Multimodal Interactive Simulations

    PubMed Central

    Halic, Tansel; Ahn, Woojin; De, Suvranu

    2015-01-01

    This paper presents a technique for optimizing the performance of web based multimodal interactive simulations. For such applications where visual quality and the performance of simulations directly influence user experience, overloading of hardware resources may result in unsatisfactory reduction in the quality of the simulation and user satisfaction. However, optimization of simulation performance on individual hardware platforms is not practical. Hence, we present a mixed integer programming model to optimize the performance of graphical rendering and simulation performance while satisfying application specific constraints. Our approach includes three distinct phases: identification, optimization and update. In the identification phase, the computing and rendering capabilities of the client device are evaluated using an exploratory proxy code. This data is utilized in conjunction with user specified design requirements in the optimization phase to ensure best possible computational resource allocation. The optimum solution is used for rendering (e.g. texture size, canvas resolution) and simulation parameters (e.g. simulation domain) in the update phase. Test results are presented on multiple hardware platforms with diverse computing and graphics capabilities to demonstrate the effectiveness of our approach. PMID:26085713

  15. Interaction of gentamicin polycation with model and cell membranes.

    PubMed

    Kovács, Eugenia; Savopol, Tudor; Iordache, Maria-Minodora; Săplăcan, Lavinia; Sobaru, Iuliana; Istrate, Claudia; Mingeot-Leclercq, Marie-Paule; Moisescu, Mihaela-Georgeta

    2012-10-01

    The interaction of positively-charged antibiotic gentamicin with cell membranes was studied to determine if any changes in membrane organization were induced by the drug. Opossum kidney epithelia (OK) cells were used as models of eukaryotic cells. Two methods were used: laurdan fluorescence spectroscopy and fluorescence anisotropy recordings on 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene p-toluenesulfonate (TMA-DPH) labeled cell suspensions. Both methods showed an altered membrane hydration and fluidity of gentamicin treated cells. Liposomes prepared from dimyristoyl-phosphatidylcholine (DMPC) mixed with cardiolipin, which mimics the heterogeneous charge composition of the natural cell membrane, were used to determine the effect of gentamicin on artificial bilayers. The membrane lipid packing as revealed by generalized polarization (GP) and fluorescence anizotropy variation with increasing temperature was studied. It was found that the generalized polarization of liposomal membranes containing a negatively charged lipid (cardiolipin) is higher in the presence of gentamicin; in the membrane of living cell (OK), gentamicin induces, on the contrary, a decrease of general polarization. Considering the role of membrane organization in the function of transmembrane channels and receptors, our findings suggest hypotheses that may explain the permeation of gentamicin through the living cell membrane by using these channels.

  16. Relationship between the Bohr-Mottelson model and the interacting boson model

    NASA Astrophysics Data System (ADS)

    Klein, Abraham; Li, Ching-Teh; Vallieres, Michel

    1982-05-01

    The interacting boson model was invented in two independent modes: The Schwinger mode using six bosons (s and five d bosons) and the Holstein-Primakoff mode using five quadrupole quasibosons. We show that the mathematical equivalence of the two modes can be used to define a number conserving quadrupole boson (the b boson). Two equivalent bases, the usual s-d basis and a new s-b basis, are exhibited. By an exercise of (possibly objectionable) physical license, the result can be interpreted as a proof of equivalence of interacting boson model I with the Bohr-Mottelson model. In the s-b basis, the Hamiltonian and other operators depend only on the b boson. In this form, all the topics usually associated with the Bohr-Mottleson model can be discussed: potential energy surface, shape parameters, vibrations vs rotations, etc. The precise relationship of our method to that employed in previous work is exposed. The latter is shown to correspond to the use of the Dyson generators of SU(6). NUCLEAR STRUCTURE Interacting bosons, Bohr-Mottelson form of IBM, potential energy surface from IBM, generator coordinates and IBM.

  17. Atmospheric numerical modeling resource enhancement and model convective parameterization/scale interaction studies

    NASA Technical Reports Server (NTRS)

    Cushman, Paula P.

    1993-01-01

    Research will be undertaken in this contract in the area of Modeling Resource and Facilities Enhancement to include computer, technical and educational support to NASA investigators to facilitate model implementation, execution and analysis of output; to provide facilities linking USRA and the NASA/EADS Computer System as well as resident work stations in ESAD; and to provide a centralized location for documentation, archival and dissemination of modeling information pertaining to NASA's program. Additional research will be undertaken in the area of Numerical Model Scale Interaction/Convective Parameterization Studies to include implementation of the comparison of cloud and rain systems and convective-scale processes between the model simulations and what was observed; and to incorporate the findings of these and related research findings in at least two refereed journal articles.

  18. Modelling land-atmosphere interactions in tropical African wetlands

    NASA Astrophysics Data System (ADS)

    Dadson, S.

    2012-04-01

    Wetlands interact with the climate system in two ways. First, the availability of water at the land surface introduces important feedbacks on climate via surface fluxes of energy and water [1]. Over wet surfaces, high daytime evaporation rates and suppressed sensible heat fluxes induce a shallower, moister planetary boundary layer, which affects atmospheric instability and favours the initiation of new storms [2]. Second, wetlands form a key link between the hydrological and carbon cycles, via anoxic degradation of organic matter to release methane (CH4). Wetlands are the largest, but least well quantified, single source of CH4, with recent emission estimates ranging from 105-278 Tg yr-1, ~75% of which comes from the tropics [3]. Although the emissions of methane from boreal wetlands and lakes are less than those from tropical wetlands [3], their size and remoteness pose significant challenges to the quantification of their feedbacks to regional and global climate. In this paper, I present a summary of recent work on modelling hydrological and biogeochemical aspects of wetland formation and the associated land-atmosphere feedbacks in African and boreal environments. We have added an overbank inundation model to the Joint UK Land Environment Simulator (JULES). Sub-grid topographic data were used to derive a two-parameter frequency distribution of inundated areas. Our predictions of inundated area are in good agreement with observed estimates of the extent of inundation obtained using satellite infrared and microwave remote sensing [4,5]. The model predicts significant evaporative losses from the inundated region accounting for doubling of the total land-atmosphere water flux during periods of greatest flooding. I also present new parameterisations of methane generation from wetlands. 1. Koster, R.D., et al., 2004, Science, 305(5687): 1138-40. 2. Taylor, C.M., 2010, Geophys. Res. Lett., 37: L05406. 3. US EPA, 2010, Methane and Nitrous Oxide Emissions From Natural

  19. Cosmological implications of Nambu-Jona-Lasinio model with a dynamical coupling

    NASA Astrophysics Data System (ADS)

    Quintanar, G. Leonardo; de La Macorra, Axel

    We study the cosmological implications of the Nambu-Jona-Lasinio (NJL) model when the coupling constant is field dependent. The NJL model has a four-fermion interaction describing two different phases due to quantum interaction effects and determined by the strength of the coupling constant g. It describes massless fermions for weak coupling and a massive fermions and strong coupling, where a fermion condensate is formed. In the original NJL model, the coupling constant g is indeed constant, and in this work we consider a modified version of the NJL model by introducing a dynamical field dependent coupling motivated by string theory. The effective potential as a function of the varying coupling (aimed to implement a natural phase transition) is seen to develop a negative divergence, i.e. becomes a “bottomless well” in certain limit region. Although we explain how an lower unbounded potential is not necessarily unacceptable in a cosmological context, the divergence can be removed if we consider a mass term for the coupling like field. We found that for a proper set of parameters, the total potential obtained has two minima, one located at the origin (the trivial solution, in which the fluid associated with the fields behave like matter); and the other related to the nontrivial solution. This last solution has three possibilities: (1) if the minimum is positive Vmin > 0, the system behaves as a cosmological constant, thus leading eventually to an accelerated universe; (2) if the minimized potential vanishes Vmin = 0, then we have matter with no acceleration; (3) finally a negative minimum Vmin < 0 leads an eventually collapsing universe with a flat geometry. Therefore, a possible interpretation as dark matter (DM) or dark energy (DE) is allowed among the behaviors implicated in the model.

  20. Tournament Management via Interactive Video Communication Systems: Models and Motives.

    ERIC Educational Resources Information Center

    Littlefield, Robert S.; Pawlowski, Donna R.

    In response to tighter school budgets and improved technology, a two-way interactive video was successfully used to provide an alternative "delivery system" for forensic competition. Two university sites were selected to organize and host an interactive video speech and debate tournament for area high school students. The program was…

  1. A Dual Aspect Process Model of Intensive Interaction

    ERIC Educational Resources Information Center

    Firth, Graham

    2009-01-01

    Intensive Interaction is an empirically researched approach to developing fundamental communication and sociability for people with severe and profound learning disabilities and/or autism. However, it is the author's contention that certain aspects of Intensive Interaction are not universally conceptualised in a uniform manner, and that there are…

  2. On Interactive Teaching Model of Translation Course Based on Wechat

    ERIC Educational Resources Information Center

    Lin, Wang

    2017-01-01

    Constructivism is a theory related to knowledge and learning, focusing on learners' subjective initiative, based on which the interactive approach has been proved to play a crucial role in language learning. Accordingly, the interactive approach can also be applied to translation teaching since translation itself is a bilingual transformational…

  3. Modeling and analysis of aerosol processes in an interactive chemistry general circulation model

    NASA Astrophysics Data System (ADS)

    Verma, Sunita; Boucher, O.; Reddy, M. S.; Upadhyaya, H. C.; Le van, P.; Binkowski, F. S.; Sharma, O. P.

    2007-02-01

    An "online" aerosol dynamics and chemistry module is included in the Laboratoire de Météorologie Dynamique general circulation model (LMDZ), so that the chemical species are advected at each dynamical time step and evolve through chemical and physical processes that have been parameterized consistently with the meteorology. These processes include anthropogenic and biogenic emissions, over 50 gas/aqueous phase chemical reactions, transport due to advection, vertical diffusion and convection, dry deposition and wet scavenging. We have introduced a size-resolved representation of aerosols which undergo various processes such as coagulation, nucleation and dry and wet scavenging. The model considers 16 prognostic tracers: water vapor, liquid water, dimethyl sulfide (DMS), hydrogen sulfide (H2S), dimethyl sulphoxide (DMSO), methanesulphonic acid (MSA), sulfur dioxide (SO2), nitrogen oxides (NOX), carbon monoxide (CO), nitric acid (HNO3), ozone (O3), hydrogen peroxide (H2O2), sulfate mass and number for Aitken and accumulation modes. The scheme accounts for two-way interactions between tropospheric chemistry and aerosols. The oxidants and chemical species fields that represent the sulfate aerosol formation are evolved interactively with the model dynamics. A detailed description on the coupled climate-chemistry interactive module is presented with the evaluation of chemical species in winter and summer seasons. Aqueous phase reactions in cloud accounted for 71% of sulfate production rate, while only 45% of the sulfate burden in the troposphere is derived from in-cloud oxidation.

  4. Smoothing for spatiotemporal models and its application to modeling muskrat-mink interaction.

    PubMed

    Zhang, Wenyang; Yao, Qiwei; Tong, Howell; Stenseth, Nils Chr

    2003-12-01

    For a set of spatially dependent dynamical models, we propose a method for estimating parameters that control temporal dynamics by spatial smoothing. The new approach is particularly relevant for analyzing spatially distributed panels of short time series. The asymptotic results show that spatial smoothing will improve the estimation in the presence of nugget effect, even when the sample size in each location is large. The proposed methodology is used to analyze the annual mink and muskrat data collected in a period of 25 years in 81 Canadian locations. Based on the proposed method, we are able to model the temporal dynamics which reflects the food chain interaction of the two species.

  5. Bianchi type I Universe and interacting ghost scalar fields models of dark energy

    NASA Astrophysics Data System (ADS)

    Hossienkhani, H.

    2016-04-01

    We suggest a correspondence between interacting ghost dark energy model with the quintessence, tachyon and K-essence scalar field in a non-isotropic universe. This correspondence allows to reconstruct the potential and the dynamics for the scalar field of the interacting ghost dark energy model, which describe accelerated expansion of the universe. Our numerical result show the effects of the interaction and anisotropic on the evolutionary behavior the ghost scalar field models.

  6. 2D DEM model of sand transport with wind interaction

    NASA Astrophysics Data System (ADS)

    Oger, L.; Valance, A.

    2013-06-01

    The advance of the dunes in the desert is a threat to the life of the local people. The dunes invade houses, agricultural land and perturb the circulation on the roads. It is therefore very important to understand the mechanism of sand transport in order to fight against desertification. Saltation in which sand grains are propelled by the wind along the surface in short hops, is the primary mode of blown sand movement [1]. The saltating grains are very energetic and when impact a sand surface, they rebound and consequently eject other particles from the sand bed. The ejected grains, called reptating grains, contribute to the augmentation of the sand flux. Some of them can be promoted to the saltation motion. We use a mechanical model based on the Discrete Element Method to study successive collisions of incident energetic beads with granular packing in the context of Aeolian saltation transport. We investigate the collision process for the case where the incident bead and those from the packing have identical mechanical properties. We analyze the features of the consecutive collision processes made by the transport of the saltating disks by a wind in which its profile is obtained from the counter-interaction between air flow and grain flows. We used a molecular dynamics method known as DEM (soft Discrete Element Method) with a initial static packing of 20000 2D particles. The dilation of the upper surface due to the consecutive collisions is responsible for maintaining the flow at a given energy input due to the wind.

  7. The eightfold way model, the SU(3)-flavor model and the medium-strong interaction

    NASA Astrophysics Data System (ADS)

    Abbas, Syed Afsar

    2015-04-01

    Lack of any baryon number in the eightfold way model, and its intrinsic presence in the SU(3)-flavor model, has been a puzzle since the genesis of these models in 1961-1964. First we show that the conventional popular understanding of this puzzle is actually fundamentally wrong, and hence the problem being so old, begs urgently for resolution. In this paper we show that the issue is linked to the way that the adjoint representation is defined mathematically for a Lie algebra, and how it manifests itself as a physical representation. This forces us to distinguish between the global and the local charges and between the microscopic and the macroscopic models. As a bonus, a consistent understanding of the hitherto mysterious medium-strong interaction is achieved. We also gain a new perspective on how confinement arises in quantum chromodynamics.

  8. Experience with turbulence interaction and turbulence-chemistry models at Fluent Inc.

    NASA Technical Reports Server (NTRS)

    Choudhury, D.; Kim, S. E.; Tselepidakis, D. P.; Missaghi, M.

    1995-01-01

    This viewgraph presentation discusses (1) turbulence modeling: challenges in turbulence modeling, desirable attributes of turbulence models, turbulence models in FLUENT, and examples using FLUENT; and (2) combustion modeling: turbulence-chemistry interaction and FLUENT equilibrium model. As of now, three turbulence models are provided: the conventional k-epsilon model, the renormalization group model, and the Reynolds-stress model. The renormalization group k-epsilon model has broadened the range of applicability of two-equation turbulence models. The Reynolds-stress model has proved useful for strongly anisotropic flows such as those encountered in cyclones, swirlers, and combustors. Issues remain, such as near-wall closure, with all classes of models.

  9. Phenomenological model of laser-tissue interaction with application to Benign Prostatic Hyperplasia (BPH) simulation.

    PubMed

    Zhou, Xiangmin; Zhang, Nan; Shen, Yunhe; Burke, Dan; Konchada, Vamsi; Sweet, Robert

    2011-01-01

    Laser-tissue interaction is a multi-physics phenomenon not yet mathematically describable and computationally predictable. It is a challenge to model the laser-tissue interaction for real time laser Benign Prostatic Hyperplasia (BPH) simulation which requires the laser-tissue interaction model to be computationally efficient and accurate. Under the consideration and enforcement of the thermodynamic first law and treating the laser-tissue interaction as a gray-box, utilizing the sensitivity analysis of some key parameters that will affect the laser intensity on the tissue surface with respect to the tissue vaporization rate, a phenomenological model of laser-tissue interaction is developed. The developed laser-tissue interaction model has been implemented for a laser BPH simulator and achieves real time performance (more than 30 frames per second). The model agrees well with the available experimental data.

  10. MODELING THE INTERACTION OF AGROCHEMICALS WITH ENVIRONMENTAL SURFACES

    EPA Science Inventory

    The interactions between agrochemicals and organo-mineral surfaces were studied using molecular mechanical conformational calculations and molecular dynamics simulations. Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine), 2,4-D (1, 2-dichlorophenoxyacetic acid), and DD...

  11. Interaction of peptides with cell membranes: insights from molecular modeling

    NASA Astrophysics Data System (ADS)

    Li, Zhen-lu; Ding, Hong-ming; Ma, Yu-qiang

    2016-03-01

    The investigation of the interaction of peptides with cell membranes is the focus of active research. It can enhance the understanding of basic membrane functions such as membrane transport, fusion, and signaling processes, and it may shed light on potential applications of peptides in biomedicine. In this review, we will present current advances in computational studies on the interaction of different types of peptides with the cell membrane. Depending on the properties of the peptide, membrane, and external environment, the peptide-membrane interaction shows a variety of different forms. Here, on the basis of recent computational progress, we will discuss how different peptides could initiate membrane pores, translocate across the membrane, induce membrane endocytosis, produce membrane curvature, form fibrils on the membrane surface, as well as interact with functional membrane proteins. Finally, we will present a conclusion summarizing recent progress and providing some specific insights into future developments in this field.

  12. Natural Interaction Metaphors for Functional Validations of Virtual Car Models.

    PubMed

    Moehring, Mathias; Froehlich, Bernd

    2011-09-01

    Natural Interaction in virtual environments is a key requirement for the virtual validation of functional aspects in automotive product development processes. Natural Interaction is the metaphor people encounter in reality: the direct manipulation of objects by their hands. To enable this kind of Natural Interaction, we propose a pseudophysical metaphor that is both plausible enough to provide realistic interaction and robust enough to meet the needs of industrial applications. Our analysis of the most common types of objects in typical automotive scenarios guided the development of a set of refined grasping heuristics to support robust finger-based interaction of multiple hands and users. The objects' behavior in reaction to the users' finger motions is based on pseudophysical simulations, which also take various types of constrained objects into account. In dealing with real-world scenarios, we had to introduce the concept of Normal Proxies, which extend objects with appropriate normals for improved grasp detection and grasp stability. An expert review revealed that our interaction metaphors allow for an intuitive and reliable assessment of several functionalities of objects found in a car interior. Follow-up user studies showed that overall task performance and usability are similar for CAVE and HMD environments. For larger objects and more gross manipulation, using the CAVE without employing a virtual hand representation is preferred, but for more fine-grained manipulation and smaller objects, the HMD turns out to be beneficial.

  13. Modelling soil-plant-atmosphere interactions by coupling the regional weather model WRF to mechanistic plant models

    NASA Astrophysics Data System (ADS)

    Klein, C.; Hoffmann, P.; Priesack, E.

    2012-04-01

    Climate change causes altering distributions of meteorological factors influencing plant growth and its interactions between the land surface and the atmosphere. Recent studies show, that uncertainties in regional and global climate simulations are also caused by lacking descriptions of the soil-plant-atmosphere system. Therefore, we couple a mechanistic soil-plant model to a regional climate and forecast model. The detailed simulation of the water and energy exchanges, especially the transpiration of grassland and forests stands, are the key features of the modelling framework. The Weather Research and Forecasting model (WRF) (Skamarock 2008) is an open source mesoscale numerical weather prediction model. The WRF model was modified in a way, to either choose its native, static land surface model NOAH or the mechanistic eco-system model Expert-N 5.0 individually for every single grid point within the simulation domain. The Expert-N 5.0 modelling framework provides a highly modular structure, enabling the development and use of a large variety of different plant and soil models, including heat transfer, nitrogen uptake/turnover/transport as well as water uptake/transport and crop management. To represent the key landuse types grassland and forest, we selected two mechanistic plant models: The Hurley Pasture model (Thornley 1998) and a modified TREEDYN3 forest simulation model (Bossel 1996). The models simulate plant growth, water, nitrogen and carbon flows for grassland and forest stands. A mosaic approach enables Expert-N to use high resolution land use data e.g. CORINE Land Cover data (CLC, 2006) for the simulation, making it possible to simulate different land use distributions within a single grid cell. The coupling results are analyzed for plausibility and compared with the results of the default land surface model NOAH (Fei Chen and Jimy Dudhia 2010). We show differences between the mechanistic and the static model coupling, with focus on the feedback effects

  14. RevBayes: Bayesian Phylogenetic Inference Using Graphical Models and an Interactive Model-Specification Language.

    PubMed

    Höhna, Sebastian; Landis, Michael J; Heath, Tracy A; Boussau, Bastien; Lartillot, Nicolas; Moore, Brian R; Huelsenbeck, John P; Ronquist, Fredrik

    2016-07-01

    Programs for Bayesian inference of phylogeny currently implement a unique and fixed suite of models. Consequently, users of these software packages are simultaneously forced to use a number of programs for a given study, while also lacking the freedom to explore models that have not been implemented by the developers of those programs. We developed a new open-source software package, RevBayes, to address these problems. RevBayes is entirely based on probabilistic graphical models, a powerful generic framework for specifying and analyzing statistical models. Phylogenetic-graphical models can be specified interactively in RevBayes, piece by piece, using a new succinct and intuitive language called Rev. Rev is similar to the R language and the BUGS model-specification language, and should be easy to learn for most users. The strength of RevBayes is the simplicity with which one can design, specify, and implement new and complex models. Fortunately, this tremendous flexibility does not come at the cost of slower computation; as we demonstrate, RevBayes outperforms competing software for several standard analyses. Compared with other programs, RevBayes has fewer black-box elements. Users need to explicitly specify each part of the model and analysis. Although this explicitness may initially be unfamiliar, we are convinced that this transparency will improve understanding of phylogenetic models in our field. Moreover, it will motivate the search for improvements to existing methods by brazenly exposing the model choices that we make to critical scrutiny. RevBayes is freely available at http://www.RevBayes.com [Bayesian inference; Graphical models; MCMC; statistical phylogenetics.].

  15. RevBayes: Bayesian Phylogenetic Inference Using Graphical Models and an Interactive Model-Specification Language

    PubMed Central

    Höhna, Sebastian; Landis, Michael J.

    2016-01-01

    Programs for Bayesian inference of phylogeny currently implement a unique and fixed suite of models. Consequently, users of these software packages are simultaneously forced to use a number of programs for a given study, while also lacking the freedom to explore models that have not been implemented by the developers of those programs. We developed a new open-source software package, RevBayes, to address these problems. RevBayes is entirely based on probabilistic graphical models, a powerful generic framework for specifying and analyzing statistical models. Phylogenetic-graphical models can be specified interactively in RevBayes, piece by piece, using a new succinct and intuitive language called Rev. Rev is similar to the R language and the BUGS model-specification language, and should be easy to learn for most users. The strength of RevBayes is the simplicity with which one can design, specify, and implement new and complex models. Fortunately, this tremendous flexibility does not come at the cost of slower computation; as we demonstrate, RevBayes outperforms competing software for several standard analyses. Compared with other programs, RevBayes has fewer black-box elements. Users need to explicitly specify each part of the model and analysis. Although this explicitness may initially be unfamiliar, we are convinced that this transparency will improve understanding of phylogenetic models in our field. Moreover, it will motivate the search for improvements to existing methods by brazenly exposing the model choices that we make to critical scrutiny. RevBayes is freely available at http://www.RevBayes.com. [Bayesian inference; Graphical models; MCMC; statistical phylogenetics.] PMID:27235697

  16. Optimal Hubbard models for materials with nonlocal Coulomb interactions: graphene, silicene, and benzene.

    PubMed

    Schüler, M; Rösner, M; Wehling, T O; Lichtenstein, A I; Katsnelson, M I

    2013-07-19

    To understand how nonlocal Coulomb interactions affect the phase diagram of correlated electron materials, we report on a method to approximate a correlated lattice model with nonlocal interactions by an effective Hubbard model with on-site interactions U(*) only. The effective model is defined by the Peierls-Feynman-Bogoliubov variational principle. We find that the local part of the interaction U is reduced according to U(*)=U-V[over ¯], where V[over ¯] is a weighted average of nonlocal interactions. For graphene, silicene, and benzene we show that the nonlocal Coulomb interaction can decrease the effective local interaction by more than a factor of 2 in a wide doping range.

  17. Interactive Rapid Dose Assessment Model (IRDAM): scenarios for comparing dose-assessment models. Vol. 3

    SciTech Connect

    Poeton, R.W.; Moeller, M.P.; Laughlin, G.J.; Desrosiers, A.E.

    1983-05-01

    The Interactive Rapid Dose Assessment Model (IRDAM) is a micro-computer based program designed to provide rapid assessments of the radiological impact of accidents at nuclear power plants. The main body of this document consists of 28 examples of IRDAM input and output, representing various types of accidents and releases. These examples are intended to provide a basis for comparison with other models or for testing IRDAM itself. Figures are included which show dose rates calculated by IRDAM for each scenario. Figures are also included which show calculations made using the computer codes WRAITH (Scherpelz, Borst and Hoenes, 1980) and RADPUR (Dabbert, et. al., 1982). Two other companion volumes to this one provide additional information on IRDAM. The User's Guide (NUREG/CR-3012, Volume 1) describes the setup and operation of equipment necessary to run IRDAM. Reactor Accident Assessment Methods (NUREG/CR-3012, Volume 2) describes the technical bases for IRDAM including methods, models and assumptions used in calculations.

  18. An immune system-tumour interactions model with discrete time delay: Model analysis and validation

    NASA Astrophysics Data System (ADS)

    Piotrowska, Monika Joanna

    2016-05-01

    In this article a generalised mathematical model describing the interactions between malignant tumour and immune system with discrete time delay incorporated into the system is considered. Time delay represents the time required to generate an immune response due to the immune system activation by cancer cells. The basic mathematical properties of the considered model, including the global existence, uniqueness, non-negativity of the solutions, the stability of steady sates and the possibility of the existence of the stability switches, are investigated when time delay is treated as a bifurcation parameter. The model is validated with the sets of the experimental data and additional numerical simulations are performed to illustrate, extend, interpret and discuss the analytical results in the context of the tumour progression.

  19. Capturing nonlocal interaction effects in the Hubbard model: Optimal mappings and limits of applicability

    NASA Astrophysics Data System (ADS)

    van Loon, E. G. C. P.; Schüler, M.; Katsnelson, M. I.; Wehling, T. O.

    2016-10-01

    We investigate the Peierls-Feynman-Bogoliubov variational principle to map Hubbard models with nonlocal interactions to effective models with only local interactions. We study the renormalization of the local interaction induced by nearest-neighbor interaction and assess the quality of the effective Hubbard models in reproducing observables of the corresponding extended Hubbard models. We compare the renormalization of the local interactions as obtained from numerically exact determinant quantum Monte Carlo to approximate but more generally applicable calculations using dual boson, dynamical mean field theory, and the random phase approximation. These more approximate approaches are crucial for any application with real materials in mind. Furthermore, we use the dual boson method to calculate observables of the extended Hubbard models directly and benchmark these against determinant quantum Monte Carlo simulations of the effective Hubbard model.

  20. Diffusion within the Cytoplasm: A Mesoscale Model of Interacting Macromolecules

    PubMed Central

    Trovato, Fabio; Tozzini, Valentina

    2014-01-01

    Recent experiments carried out in the dense cytoplasm of living cells have highlighted the importance of proteome composition and nonspecific intermolecular interactions in regulating macromolecule diffusion and organization. Despite this, the dependence of diffusion-interaction on physicochemical properties such as the degree of poly-dispersity and the balance between steric repulsion and nonspecific attraction among macromolecules was not systematically addressed. In this work, we study the problem of diffusion-interaction in the bacterial cytoplasm, combining theory and experimental data to build a minimal coarse-grained representation of the cytoplasm, which also includes, for the first time to our knowledge, the nucleoid. With stochastic molecular-dynamics simulations of a virtual cytoplasm we are able to track the single biomolecule motion, sizing from 3 to 80 nm, on submillisecond-long trajectories. We demonstrate that the size dependence of diffusion coefficients, anomalous exponents, and the effective viscosity experienced by biomolecules in the cytoplasm is fine-tuned by the intermolecular interactions. Accounting only for excluded volume in these potentials gives a weaker size-dependence than that expected from experimental data. On the contrary, adding nonspecific attraction in the range of 1–10 thermal energy units produces a stronger variation of the transport properties at growing biopolymer sizes. Normal and anomalous diffusive regimes emerge straightforwardly from the combination of high macromolecular concentration, poly-dispersity, stochasticity, and weak nonspecific interactions. As a result, small biopolymers experience a viscous cytoplasm, while the motion of big ones is jammed because the entanglements produced by the network of interactions and the entropic effects caused by poly-dispersity are stronger. PMID:25468337

  1. A componential model of human interaction with graphs: 1. Linear regression modeling

    NASA Technical Reports Server (NTRS)

    Gillan, Douglas J.; Lewis, Robert

    1994-01-01

    Task analyses served as the basis for developing the Mixed Arithmetic-Perceptual (MA-P) model, which proposes (1) that people interacting with common graphs to answer common questions apply a set of component processes-searching for indicators, encoding the value of indicators, performing arithmetic operations on the values, making spatial comparisons among indicators, and repsonding; and (2) that the type of graph and user's task determine the combination and order of the components applied (i.e., the processing steps). Two experiments investigated the prediction that response time will be linearly related to the number of processing steps according to the MA-P model. Subjects used line graphs, scatter plots, and stacked bar graphs to answer comparison questions and questions requiring arithmetic calculations. A one-parameter version of the model (with equal weights for all components) and a two-parameter version (with different weights for arithmetic and nonarithmetic processes) accounted for 76%-85% of individual subjects' variance in response time and 61%-68% of the variance taken across all subjects. The discussion addresses possible modifications in the MA-P model, alternative models, and design implications from the MA-P model.

  2. The Yale Interactive terrestrial Biosphere model: description, evaluation and implementation into NASA GISS ModelE2

    NASA Astrophysics Data System (ADS)

    Yue, X.; Unger, N.

    2015-04-01

    The land biosphere, atmospheric chemistry and climate are inextricably interconnected. We describe the Yale Interactive terrestrial Biosphere (YIBs) model, a land carbon cycle model that has been developed for coupling to the NASA Goddard Institute for Space Studies (GISS) ModelE2 global chemistry-climate model. The YIBs model adapts routines from the mature TRIFFID and CASA models to simulate interactive carbon assimilation, allocation, and autotrophic and heterotrophic respiration. Dynamic daily leaf area index is simulated based on carbon allocation and temperature- and drought-dependent prognostic phenology. YIBs incorporates a semi-mechanistic ozone vegetation damage scheme. Here, we validate the present day YIBs land carbon fluxes for three increasingly complex configurations: (i) off-line local site-level (ii) off-line global forced with WFDEI (WATCH Forcing Data methodology applied to ERA-Interim data) meteorology (iii) on-line coupled to the NASA ModelE2 (NASA ModelE2-YIBs). Off-line YIBs has hourly and on-line YIBs has half-hourly temporal resolution. The large observational database used for validation includes carbon fluxes from 145 flux tower sites and multiple satellite products. At the site level, YIBs simulates reasonable seasonality (correlation coefficient R > 0.8) of gross primary productivity (GPP) at 121 out of 145 sites with biases in magnitude ranging from -19 to 7% depending on plant function type. On the global scale, the off-line model simulates an annual GPP of 125 ± 3 petagrams of carbon (Pg C) and net ecosystem exchange (NEE) of -2.5 ± 0.7 Pg C for 1982-2011, with seasonality and spatial distribution consistent with the satellite observations. We assess present day global ozone vegetation damage using the off-line YIBs configuration. Ozone damage reduces global GPP by 2-5% annually with regional extremes of 4-10% in East Asia. The on-line model simulates annual GPP of 123 ± 1 Pg C and NEE of -2.7 ± 0.7 Pg C. NASA ModelE2-YIBs is a

  3. Modeling the accessibility of the interaction of clonazepan to albumins

    NASA Astrophysics Data System (ADS)

    Valdez, Ethel Celene Narvaez; Paulino, Erica Tex; de Morais e Coura, Carla Patrícia; Cortez, Celia Martins; da Silva Fragoso, Viviane Muniz

    2016-12-01

    This paper shows results obtained from the clonazepam (CNZP) interaction with human and bovine serum albumin study, seeking data on the pharmacokinetics and the binding site for the anxiolytic by comparing the responses of these two proteins to this drug. The quenching response of this experiment show a huge interaction between CNZP and the albumins, that confirm the literature information relative to the high affinity of CNZP with the plasma protein, a long plasma half-life and that the single binding site for this drug can be found in or close to subdomain IB of HSA and BSA.

  4. A Model for Infall-Outflow Interactions in Protostellar Disks

    NASA Technical Reports Server (NTRS)

    Velusamy, W. Langer T.

    1997-01-01

    Recently we have shown(sup 1,2) from (sup 12)CO and C(sup 18)O OVRO-MMA observations evidence of infall-outflow interactions in the Young Stellar Object IRS1 in B5. We present new data obtained with the OVRO-MMA in (sup 13)CO(2-1) and (1-0) to trace the full extent of this infall-outflow interaction region.

  5. Mathematical Analysis of a Coarsening Model with Local Interactions

    NASA Astrophysics Data System (ADS)

    Helmers, Michael; Niethammer, Barbara; Velázquez, Juan J. L.

    2016-10-01

    We consider particles on a one-dimensional lattice whose evolution is governed by nearest-neighbor interactions where particles that have reached size zero are removed from the system. Concentrating on configurations with infinitely many particles, we prove existence of solutions under a reasonable density assumption on the initial data and show that the vanishing of particles and the localized interactions can lead to non-uniqueness. Moreover, we provide a rigorous upper coarsening estimate and discuss generic statistical properties as well as some non-generic behavior of the evolution by means of heuristic arguments and numerical observations.

  6. Hadron-Hadron Interactions in the Constituent Quark Model: Results and Extensions

    SciTech Connect

    Eric S. Swanson

    2001-01-01

    Hadronic interactions are discussed within the context of the constituent quark model. The ''Quark Born Diagram'' methodology is outlined, extensive applications to meson-meson and meson-baryon interactions are discussed, and general features of these interactions are highlighted. The second half of this document deals with shortcomings of the quark model approach and methods to overcome them. These include relativistic kinematics, unitarity, nonlocal potentials, coupled channel effects, and the chiral nature of the pion.

  7. Interactions of Metacognition with Motivation and Affect in Self-Regulated Learning: The MASRL Model

    ERIC Educational Resources Information Center

    Efklides, Anastasia

    2011-01-01

    Metacognition, motivation, and affect are components of self-regulated learning (SRL) that interact. The "metacognitive and affective model of self-regulated learning" (the MASRL model) distinguishes two levels of functioning in SRL, namely, the Person level and the Task x Person level. At the Person level interactions between trait-like…

  8. Marginal Maximum Likelihood Estimation of a Latent Variable Model with Interaction

    ERIC Educational Resources Information Center

    Cudeck, Robert; Harring, Jeffrey R.; du Toit, Stephen H. C.

    2009-01-01

    There has been considerable interest in nonlinear latent variable models specifying interaction between latent variables. Although it seems to be only slightly more complex than linear regression without the interaction, the model that includes a product of latent variables cannot be estimated by maximum likelihood assuming normality.…

  9. Modelling interactions of carbon dioxide, forests, and climate

    SciTech Connect

    Luxmoore, R.J.; Baldocchi, D.D.

    1994-09-01

    Atmospheric carbon dioxide is rising and forests and climate is changing! This combination of fact and premise may be evaluated at a range of temporal and spatial scales with the aid of computer simulators describing the interrelationships between forest vegetation, litter and soil characteristics, and appropriate meteorological variables. Some insights on the effects of climate on the transfers of carbon and the converse effect of carbon transfer on climate are discussed as a basis for assessing the significance of feedbacks between vegetation and climate under conditions of rising atmospheric carbon dioxide. Three main classes of forest models are reviewed. These are physiologically-based models, forest succession simulators based on the JABOWA model, and ecosystem-carbon budget models that use compartment transfer rates with empirically estimated coefficients. Some regression modeling approaches are also outlined. Energy budget models applied to forests and grasslands are also reviewed. This review presents examples of forest models; a comprehensive discussion of all available models is not undertaken.

  10. IMPACT: Interactive Model for Professional Action and Change for Teachers.

    ERIC Educational Resources Information Center

    Knight, Martha; And Others

    1981-01-01

    A model of classroom-based staff development for teachers at the high school level is described. The program incorporates the consulting teacher model and uses three kinds of inservice training: courses, consultations, and workshops. (JN)

  11. Modeling Heterogeneity in Social Interaction Processes Using Multilevel Survival Analysis

    ERIC Educational Resources Information Center

    Stoolmiller, Mike; Snyder, James

    2006-01-01

    More than 15 years ago, survival or hazard regression analyses were introduced to psychology (W. Gardner & W. A. Griffin, 1989; W. A. Griffin & W. Gardner, 1989) as powerful methodological tools for studying real time social interaction processes among dyads. Almost no additional published applications have appeared, although such data are…

  12. Connecting Protein Structure to Intermolecular Interactions: A Computer Modeling Laboratory

    ERIC Educational Resources Information Center

    Abualia, Mohammed; Schroeder, Lianne; Garcia, Megan; Daubenmire, Patrick L.; Wink, Donald J.; Clark, Ginevra A.

    2016-01-01

    An understanding of protein folding relies on a solid foundation of a number of critical chemical concepts, such as molecular structure, intra-/intermolecular interactions, and relating structure to function. Recent reports show that students struggle on all levels to achieve these understandings and use them in meaningful ways. Further, several…

  13. Using Threshold Autoregressive Models to Study Dyadic Interactions

    ERIC Educational Resources Information Center

    Hamaker, Ellen L.; Zhang, Zhiyong; van der Maas, Han L. J.

    2009-01-01

    Considering a dyad as a dynamic system whose current state depends on its past state has allowed researchers to investigate whether and how partners influence each other. Some researchers have also focused on how differences between dyads in their interaction patterns are related to other differences between them. A promising approach in this area…

  14. The criterion-calibration model of cue interaction in contingency judgments.

    PubMed

    Hannah, Samuel D; Allan, Lorraine G

    2011-05-01

    Siegel, Allan, Hannah, and Crump (2009) demonstrated that cue interaction effects in human contingency judgments reflect processing that occurs after the acquisition of information. This finding is in conflict with a broad class of theories. We present a new postacquisition model, the criterion-calibration model, that describes cue interaction effects as involving shifts in a report criterion. The model accounts for the Siegel et al. data and outperforms the only other postacquisition model of cue interaction, Stout and Miller's (2007) SOCR model. We present new data from an experiment designed to evaluate a prediction of the two models regarding reciprocal cue interaction effects. The new data provide further support for the criterion-calibration model.

  15. A DIAGENETIC MODEL FOR SEDIMENT-SEAGRASS INTERACTIONS

    EPA Science Inventory

    The objective of this modeling effort was to better understand the dynamic relationship between seagrass beds and their sedimentary environment using a diagenetic model. The model was developed and optimized for sediments in the Laguna Madre, TX, which is one of the world's larg...

  16. Mitral valve dynamics in structural and fluid-structure interaction models.

    PubMed

    Lau, K D; Diaz, V; Scambler, P; Burriesci, G

    2010-11-01

    Modelling and simulation of heart valves is a challenging biomechanical problem due to anatomical variability, pulsatile physiological pressure loads and 3D anisotropic material behaviour. Current valvular models based on the finite element method can be divided into: those that do model the interaction between the blood and the valve (fluid-structure interaction or 'wet' models) and those that do not (structural models or 'dry' models). Here an anatomically sized model of the mitral valve has been used to compare the difference between structural and fluid-structure interaction techniques in two separately simulated scenarios: valve closure and a cardiac cycle. Using fluid-structure interaction, the valve has been modelled separately in a straight tubular volume and in a U-shaped ventricular volume, in order to analyse the difference in the coupled fluid and structural dynamics between the two geometries. The results of the structural and fluid-structure interaction models have shown that the stress distribution in the closure simulation is similar in all the models, but the magnitude and closed configuration differ. In the cardiac cycle simulation significant differences in the valvular dynamics were found between the structural and fluid-structure interaction models due to difference in applied pressure loads. Comparison of the fluid domains of the fluid-structure interaction models have shown that the ventricular geometry generates slower fluid velocity with increased vorticity compared to the tubular geometry. In conclusion, structural heart valve models are suitable for simulation of static configurations (opened or closed valves), but in order to simulate full dynamic behaviour fluid-structure interaction models are required.

  17. Brain tumor modeling: glioma growth and interaction with chemotherapy

    NASA Astrophysics Data System (ADS)

    Banaem, Hossein Y.; Ahmadian, Alireza; Saberi, Hooshangh; Daneshmehr, Alireza; Khodadad, Davood

    2011-10-01

    In last decade increasingly mathematical models of tumor growths have been studied, particularly on solid tumors which growth mainly caused by cellular proliferation. In this paper we propose a modified model to simulate the growth of gliomas in different stages. Glioma growth is modeled by a reaction-advection-diffusion. We begin with a model of untreated gliomas and continue with models of polyclonal glioma following chemotherapy. From relatively simple assumptions involving homogeneous brain tissue bounded by a few gross anatomical landmarks (ventricles and skull) the models have been expanded to include heterogeneous brain tissue with different motilities of glioma cells in grey and white matter. Tumor growth is characterized by a dangerous change in the control mechanisms, which normally maintain a balance between the rate of proliferation and the rate of apoptosis (controlled cell death). Result shows that this model closes to clinical finding and can simulate brain tumor behavior properly.

  18. Model-experiment interaction to improve representation of phosphorus limitation in land models

    NASA Astrophysics Data System (ADS)

    Norby, R. J.; Yang, X.; Cabugao, K. G. M.; Childs, J.; Gu, L.; Haworth, I.; Mayes, M. A.; Porter, W. S.; Walker, A. P.; Weston, D. J.; Wright, S. J.

    2015-12-01

    Carbon-nutrient interactions play important roles in regulating terrestrial carbon cycle responses to atmospheric and climatic change. None of the CMIP5 models has included routines to represent the phosphorus (P) cycle, although P is commonly considered to be the most limiting nutrient in highly productive, lowland tropical forests. Model simulations with the Community Land Model (CLM-CNP) show that inclusion of P coupling leads to a smaller CO2 fertilization effect and warming-induced CO2 release from tropical ecosystems, but there are important uncertainties in the P model, and improvements are limited by a dearth of data. Sensitivity analysis identifies the relative importance of P cycle parameters in determining P availability and P limitation, and thereby helps to define the critical measurements to make in field campaigns and manipulative experiments. To improve estimates of P supply, parameters that describe maximum amount of labile P in soil and sorption-desorption processes are necessary for modeling the amount of P available for plant uptake. Biochemical mineralization is poorly constrained in the model and will be improved through field observations that link root traits to mycorrhizal activity, phosphatase activity, and root depth distribution. Model representation of P demand by vegetation, which currently is set by fixed stoichiometry and allometric constants, requires a different set of data. Accurate carbon cycle modeling requires accurate parameterization of the photosynthetic machinery: Vc,max and Jmax. Relationships between the photosynthesis parameters and foliar nutrient (N and P) content are being developed, and by including analysis of covariation with other plant traits (e.g., specific leaf area, wood density), we can provide a basis for more dynamic, trait-enabled modeling. With this strong guidance from model sensitivity and uncertainty analysis, field studies are underway in Puerto Rico and Panama to collect model-relevant data on P

  19. Three dimensional modeling of Laser-Plasma interaction: benchmarking our predictive modeling tools vs. experiments

    SciTech Connect

    Divol, L; Berger, R; Meezan, N; Froula, D H; Dixit, S; Suter, L; Glenzer, S H

    2007-11-08

    We have developed a new target platform to study Laser Plasma Interaction in ignition-relevant condition at the Omega laser facility (LLE/Rochester)[1]. By shooting an interaction beam along the axis of a gas-filled hohlraum heated by up to 17 kJ of heater beam energy, we were able to create a millimeter-scale underdense uniform plasma at electron temperatures above 3 keV. Extensive Thomson scattering measurements allowed us to benchmark our hydrodynamic simulations performed with HYDRA[2]. As a result of this effort, we can use with much confidence these simulations as input parameters for our LPI simulation code pF3d[3]. In this paper, we show that by using accurate hydrodynamic profiles and full three-dimensional simulations including a realistic modeling of the laser intensity pattern generated by various smoothing options, whole beam three-dimensional linear kinetic modeling of stimulated Brillouin scattering reproduces quantitatively the experimental measurements(SBS thresholds, reflectivity values and the absence of measurable SRS). This good agreement was made possible by the recent increase in computing power routinely available for such simulations. These simulations accurately predicted the strong reduction of SBS measured when polarization smoothing is used.

  20. Three-dimensional modeling of laser-plasma interaction: Benchmarking our predictive modeling tools versus experiments

    SciTech Connect

    Divol, L.; Berger, R. L.; Meezan, N. B.; Froula, D. H.; Dixit, S.; Michel, P.; London, R.; Strozzi, D.; Ross, J.; Williams, E. A.; Still, B.; Suter, L. J.; Glenzer, S. H.

    2008-05-15

    New experimental capabilities [Froula et al., Phys. Rev. Lett. 98, 085001 (2007)] have been developed to study laser-plasma interaction (LPI) in ignition-relevant condition at the Omega laser facility (LLE/Rochester). By shooting an interaction beam along the axis of a gas-filled hohlraum heated by up to 17 kJ of heater beam energy, a millimeter-scale underdense uniform plasma at electron temperatures above 3 keV was created. Extensive Thomson scattering measurements allowed to benchmark hydrodynamic simulations performed with HYDRA [Meezan et al., Phys. Plasmas 14, 056304 (2007)]. As a result of this effort, these simulations can be used with much confidence as input parameters for the LPI simulation code PF3D [Berger et al., Phys. Plasmas 5, 4337 (1998)]. In this paper, it is shown that by using accurate hydrodynamic profiles and full three-dimensional simulations including a realistic modeling of the laser intensity pattern generated by various smoothing options, whole beam three-dimensional linear kinetic modeling of stimulated Brillouin scattering (SBS) reproduces quantitatively the experimental measurements (SBS thresholds, reflectivity values, and the absence of measurable stimulated Raman scattering). This good agreement was made possible by the recent increase in computing power routinely available for such simulations. These simulations accurately predicted the strong reduction of SBS measured when polarization smoothing is used.

  1. Biophysical interactions with model lipid membranes: applications in drug discovery and drug delivery

    PubMed Central

    Peetla, Chiranjeevi; Stine, Andrew; Labhasetwar, Vinod

    2009-01-01

    The transport of drugs or drug delivery systems across the cell membrane is a complex biological process, often difficult to understand because of its dynamic nature. In this regard, model lipid membranes, which mimic many aspects of cell-membrane lipids, have been very useful in helping investigators to discern the roles of lipids in cellular interactions. One can use drug-lipid interactions to predict pharmacokinetic properties of drugs, such as their transport, biodistribution, accumulation, and hence efficacy. These interactions can also be used to study the mechanisms of transport, based on the structure and hydrophilicity/hydrophobicity of drug molecules. In recent years, model lipid membranes have also been explored to understand their mechanisms of interactions with peptides, polymers, and nanocarriers. These interaction studies can be used to design and develop efficient drug delivery systems. Changes in the lipid composition of cells and tissue in certain disease conditions may alter biophysical interactions, which could be explored to develop target-specific drugs and drug delivery systems. In this review, we discuss different model membranes, drug-lipid interactions and their significance, studies of model membrane interactions with nanocarriers, and how biophysical interaction studies with lipid model membranes could play an important role in drug discovery and drug delivery. PMID:19432455

  2. Interaction of Boron Nitride Nanosheets with Model Cell Membranes.

    PubMed

    Hilder, Tamsyn A; Gaston, Nicola

    2016-06-03

    Boron nitride nanomaterials have attracted attention for biomedical applications, due to their improved biocompatibility when compared with carbon nanomaterials. Recently, graphene and graphene oxide nanosheets have been shown, both experimentally and computationally, to destructively extract phospholipids from Escherichia coli. Boron nitride nanosheets (BNNSs) have exciting potential biological and environmental applications, for example the ability to remove oil from water. These applications are likely to increase the exposure of prokaryotes and eukaryotes to BNNSs. Yet, despite their promise, the interaction between BNNSs and cell membranes has not yet been investigated. Here, all-atom molecular dynamics simulations were used to demonstrate that BNNSs are spontaneously attracted to the polar headgroups of the lipid bilayer. The BNNSs do not passively cross the lipid bilayer, most likely due to the large forces experienced by the BNNSs. This study provides insight into the interaction of BNNSs with cell membranes and may aid our understanding of their improved biocompatibility.

  3. Can dielectric spheres accurately model atomic-scale interactions?

    NASA Astrophysics Data System (ADS)

    Obolensky, O. I.; Doerr, T. P.; Ogurtsov, A. Y.; Yu, Yi-Kuo

    2016-10-01

    We calculate the polarization portion of electrostatic interactions at the atomic scale using quantum-mechanical methods such as density functional theories (DFT) and the coupled cluster approach, and using classical methods such as a surface charge method and a polarizable force field. The agreement among various methods is investigated. Using the coupled clusters method CCSD(T) with large basis sets as the reference, we find that for systems comprising two to six atoms and ions in S-states the classical surface charge method performs much better than commonly used DFT methods with moderate basis sets such as B3LYP/6-31G(d,p). The remarkable performance of the classical approach comes as a surprise. The present results indicate that the use of a rigorous formalism of classical electrostatics can be better justified for determining molecular interactions at intermediate distances than some of the widely used methods of quantum chemistry.

  4. Novel simulation model for many-body multipole dispersion interactions

    NASA Astrophysics Data System (ADS)

    van der Hoef Paul, Martin A.; Madden, A.

    We present a novel simulation technique, within the framework of a molecular dynamics simulation, which accounts for both two- and three-body dispersion interactions, up to the triple-quadrupole interaction. This technique involves a unification of molecular dynamics and quantum-mechanical variational methods, in the spirit of the Car-Parrinello method. The advantage of this new method compared to existing techniques for simulating three-body dispersion forces, is that it allows for a consistent treatment of both dispersion damping and periodic boundary conditions at the pair and three-body level. The latter means that it would be possible, for the first time, to include many-body dispersion effects in the simulation of bulk properties of materials, without making use of effective pair potentials.

  5. Finite Element Modeling of Intermuscular Interactions and Myofascial Force Transmission

    DTIC Science & Technology

    2001-10-25

    obtained explain force differences at the distal and proximal tendons of muscles that have mechanical interaction. This is in agreement with experimental...consequence is that active force generated within one muscle may be exerted at the tendon of another muscle. Keywords- Finite element method...7]. Therefore, in vivo there is an additional route for force transmission out off the muscle, which completely bypasses the tendon of the muscle

  6. Unveiling Bacterial Interactions through Multidimensional Scaling and Dynamics Modeling

    PubMed Central

    Dorado-Morales, Pedro; Vilanova, Cristina; P. Garay, Carlos; Martí, Jose Manuel; Porcar, Manuel

    2015-01-01

    We propose a new strategy to identify and visualize bacterial consortia by conducting replicated culturing of environmental samples coupled with high-throughput sequencing and multidimensional scaling analysis, followed by identification of bacteria-bacteria correlations and interactions. We conducted a proof of concept assay with pine-tree resin-based media in ten replicates, which allowed detecting and visualizing dynamical bacterial associations in the form of statistically significant and yet biologically relevant bacterial consortia. PMID:26671778

  7. Integrated Predictive Models for ICRF-Edge Plasma Interactions

    SciTech Connect

    Daniel A. D'Ippolito

    2005-07-20

    The coupling of radiofrequency waves to the edge plasma of a fusion device produces strong nonlinear interactions with the plasma and surrounding material walls which must be controlled in order to protect the antenna and to obtain efficient heating of the core plasma. The goal of the STTR project was to develop the first quantitative numerical simulation of this problem. This report describes the results of the Phase I work by Lodestar and ORNL on this project.

  8. A Framework for Modeling Human-Machine Interactions

    NASA Technical Reports Server (NTRS)

    Shafto, Michael G.; Rosekind, Mark R. (Technical Monitor)

    1996-01-01

    Modern automated flight-control systems employ a variety of different behaviors, or modes, for managing the flight. While developments in cockpit automation have resulted in workload reduction and economical advantages, they have also given rise to an ill-defined class of human-machine problems, sometimes referred to as 'automation surprises'. Our interest in applying formal methods for describing human-computer interaction stems from our ongoing research on cockpit automation. In this area of aeronautical human factors, there is much concern about how flight crews interact with automated flight-control systems, so that the likelihood of making errors, in particular mode-errors, is minimized and the consequences of such errors are contained. The goal of the ongoing research on formal methods in this context is: (1) to develop a framework for describing human interaction with control systems; (2) to formally categorize such automation surprises; and (3) to develop tests for identification of these categories early in the specification phase of a new human-machine system.

  9. An Arctic Ice/Ocean Coupled Model with Wave Interactions

    DTIC Science & Technology

    2015-09-30

    contemporary Arctic climate models. OBJECTIVES To make progress with our long-term goals, over the lifetime of the project we will – further our...performance of climate models in predicting the rate of disappearance of Arctic sea ice (Jeffries et al., 2013), are fuelling considerable interest in the...coupled climate models will also benefit, for although direct ocean wave effects are unlikely to be subsumed in global scale simulations because of

  10. Interaction of methotrexate with trypsin analyzed by spectroscopic and molecular modeling methods

    NASA Astrophysics Data System (ADS)

    Wang, Yanqing; Zhang, Hongmei; Cao, Jian; Zhou, Qiuhua

    2013-11-01

    Trypsin is one of important digestive enzymes that have intimate correlation with human health and illness. In this work, the interaction of trypsin with methotrexate was investigated by spectroscopic and molecular modeling methods. The results revealed that methotrexate could interact with trypsin with about one binding site. Methotrexate molecule could enter into the primary substrate-binding pocket, resulting in inhibition of trypsin activity. Furthermore, the thermodynamic analysis implied that electrostatic force, hydrogen bonding, van der Waals and hydrophobic interactions were the main interactions for stabilizing the trypsin-methotrexate system, which agreed well with the results from the molecular modeling study.

  11. Nonlinear Model of the Specificity of DNA-Protein Interactions and Its Stability

    NASA Astrophysics Data System (ADS)

    Dwiputra, D.; Hidayat, W.; Khairani, R.; Zen, F. P.

    2016-08-01

    Specific DNA-protein interactions are fundamental processes of living cells. We propose a new model of DNA-protein interactions to explain the site specificity of the interactions. The hydrogen bonds between DNA base pairs and between DNA-protein peptide groups play a significant role in determination of the specific binding site. We adopt the Morse potential with coupling terms to construct the Hamiltonian of coupled oscillators representing the hydrogen bonds in which the depth of the potentials vary in the DNA chain. In this paper we investigate the stability of the model to determine the conditions satisfying the biological circumstances of the DNA-protein interactions.

  12. Optimal Vaccination in a Stochastic Epidemic Model of Two Non-Interacting Populations

    DTIC Science & Technology

    2015-02-17

    RESEARCH ARTICLE Optimal Vaccination in a Stochastic Epidemic Model of Two Non-Interacting Populations Edwin C. Yuan1,3, David L. Alderson2, Sean...Infected-Recovered (SIR) model. Based on these results, we determine the optimal alloca- tions of a limited quantity of vaccine between two non-interacting... vaccine , the deterministic model is a poor estimate of the optimal strategy for the more realistic, stochastic case. Introduction As rapid, long-range

  13. Evaluation of Aerosol-Cloud Interactions in GISS ModelE Using ASR Observations

    NASA Astrophysics Data System (ADS)

    de Boer, G.; Menon, S.; Bauer, S. E.; Toto, T.; Bennartz, R.; Cribb, M.

    2011-12-01

    The impacts of aerosol particles on clouds continue to rank among the largest uncertainties in global climate simulation. In this work we assess the capability of the NASA GISS ModelE, coupled to MATRIX aerosol microphysics, in correctly representing warm-phase aerosol-cloud interactions. This evaluation is completed through the analysis of a nudged, multi-year global simulation using measurements from various US Department of Energy sponsored measurement campaigns and satellite-based observations. Campaign observations include the Aerosol Intensive Operations Period (Aerosol IOP) and Routine ARM Arial Facility Clouds with Low Optical Water Depths (CLOWD) Optical Radiative Observations (RACORO) at the Southern Great Plains site in Oklahoma, the Marine Stratus Radiation, Aerosol, and Drizzle (MASRAD) campaign at Pt. Reyes, California, and the ARM mobile facility's 2008 deployment to China. This combination of datasets provides a variety of aerosol and atmospheric conditions under which to test ModelE parameterizations. In addition to these localized comparisons, we provide the results of global evaluations completed using measurements derived from satellite remote sensors. We will provide a basic overview of simulation performance, as well as a detailed analysis of parameterizations relevant to aerosol indirect effects.

  14. Computational Modeling of Laser-Cell Biochemical Interactions

    DTIC Science & Technology

    2010-12-31

    The charts (from upper left, and across to lower right) present the modeled response in the RPE cell of Vitamin C (asc/ ascH ), some reactive oxygen...Husinsky, J., Seiser, B., Edthofer, F., Fekete, B., Farmer , L., and Lund, D., “Ex vivo and computer model study on retinal thermal laser-induced damage

  15. Interactive Model-Centric Systems Engineering (IMCSE) Phase Two

    DTIC Science & Technology

    2015-02-28

    Figure 35. Role of key models for supporting system decision making , with alternative value models use in demonstration case... make trades and decide on what is most effective given the present knowledge and future uncertainties, as well as make logical decisions based on the...and methods for mitigating computational resource restrictions that facilitate improved decision - making . A preliminary method has been developed with

  16. AISIM (Automated Interactive Simulation Model) Training Examples Manual.

    DTIC Science & Technology

    1982-02-26

    19 7 Messae rraffic Characteristics .................... 21 8 Message Traffic Matrices ........................... 22 9 Example I Model Structure...Figure 7. Message destinations are ’elected according to tne traffic matrices presenteu in Figare 8. Dalta messages each nave three destinations wnica...destination, processed and eliminated. Eaca of tnese events can be modeled by procedural operacions . Page 69 * 1.-- *,..., .*’. Aany slots circulate on

  17. The Thirring interaction in the two-dimensional axial-current-pseudoscalar derivative coupling model

    SciTech Connect

    Belvedere, L.V. . E-mail: armflavio@if.uff.br

    2006-12-15

    We reexamine the two-dimensional model of massive fermions interacting with a massless pseudoscalar field via axial-current derivative coupling. The hidden Thirring interaction in the axial-derivative coupling model is exhibited compactly by performing a canonical field transformation on the Bose field algebra and the model is mapped into the Thirring model with an additional vector-current-scalar derivative interaction (Schroer-Thirring model). The Fermi field operator is rewritten in terms of the Mandelstam soliton operator coupled to a free massless scalar field. The charge sectors of the axial-derivative model are mapped into the charge sectors of the massive Thirring model. The complete bosonized version of the model is presented. The bosonized composite operators of the quantum Hamiltonian are obtained as the leading operators in the Wilson short distance expansions.

  18. An Interactive Multi-Model for Consensus on Climate Change

    SciTech Connect

    Kocarev, Ljupco

    2014-07-02

    This project purports to develop a new scheme for forming consensus among alternative climate models, that give widely divergent projections as to the details of climate change, that is more intelligent than simply averaging the model outputs, or averaging with ex post facto weighting factors. The method under development effectively allows models to assimilate data from one another in run time with weights that are chosen in an adaptive training phase using 20th century data, so that the models synchronize with one another as well as with reality. An alternate approach that is being explored in parallel is the automated combination of equations from different models in an expert-system-like framework.

  19. a Gaussian Process Based Multi-Person Interaction Model

    NASA Astrophysics Data System (ADS)

    Klinger, T.; Rottensteiner, F.; Heipke, C.

    2016-06-01

    Online multi-person tracking in image sequences is commonly guided by recursive filters, whose predictive models define the expected positions of future states. When a predictive model deviates too much from the true motion of a pedestrian, which is often the case in crowded scenes due to unpredicted accelerations, the data association is prone to fail. In this paper we propose a novel predictive model on the basis of Gaussian Process Regression. The model takes into account the motion of every tracked pedestrian in the scene and the prediction is executed with respect to the velocities of all interrelated persons. As shown by the experiments, the model is capable of yielding more plausible predictions even in the presence of mutual occlusions or missing measurements. The approach is evaluated on a publicly available benchmark and outperforms other state-of-the-art trackers.

  20. Modelling strong interactions and longitudinally polarized vector boson scattering

    NASA Astrophysics Data System (ADS)

    Falkowski, Adam; Pokorski, Stefan; Roberts, J. P.

    2007-12-01

    We study scattering of the electroweak gauge bosons in 5D warped models. Within two different models we determine the precise manner in which the Higgs boson and the vector resonances ensure the unitarity of longitudinal vector boson scattering. We identify three separate scales that determine the dynamics of the scattering process in all cases. For a quite general background geometry of 5D, these scales can be linked to a simple functional of the warp factor. The models smoothly interpolate between a `composite' Higgs limit and a Higgsless limit. By holographic arguments, these models provide an effective description of vector boson scattering in 4D models with a strongly coupled electroweak breaking sector.