Managing the Increasing Water Footprint of Hydraulic Fracturing in the Bakken Play, United States.

PubMed

Scanlon, Bridget R; Reedy, Robert C; Male, Frank; Hove, Michael

2016-09-20

The water footprint of oil production, including water used for hydraulic fracturing (HF) and flowback-produced (FP) water, is increasingly important in terms of HF water sourcing and FP water management. Here, we evaluate trends in HF water use relative to supplies and FP water relative to disposal using well by well analysis in the Bakken Play. HF water use per well increased by ∼6 times from 2005-2014, totaling 24.5 × 10(9) gal (93 × 10(9) L) for ∼10 140 wells. Water supplies expanded to meet increased demand, including access of up to ∼33 × 10(9) gal/year (125 × 10(9) L/year) from Lake Sakakawea, expanding pipeline infrastructure by hundreds of miles and allowing water transfers from irrigation. The projected inventory of ∼60 000 future wells should require an additional ∼11 times more HF water. Cumulative FP water has been managed by disposal into an increasing number (277 to 479) of salt water disposal wells. FP water is projected to increase by ∼10 times during the play lifetime (∼40 years). Disposal of FP water into deeper geologic units should be considered because of reported overpressuring of parts of the Dakota Group. The long time series shows how policies have increased water supplies for HF and highlights potential issues related to FP water management.

New/Future Approaches to Explosive/Chemicals Detection

NASA Astrophysics Data System (ADS)

Valkovic, Vlado

2009-03-01

Although there has been some reported progress in many systems used for threat material detection and identification a promising one seems to be the use of tagged fast neutrons generated in d+t→α+n nuclear reaction. Among others, EU-FP6 project EURITRACK has been a successful demonstration of the use of tagged neutrons for ship container inspections. It has been shown that the deployment of the same technology under-water is a feasibility to be realized in the near future (i.e. EU-FP7 project UNCOSS).

Women's development key to MCH/FP.

PubMed

1991-05-01

The Sri Lankan government has included women in its development process thereby raising literacy levels to 91% for urban women and 87% for rural women. Their successful participation has in turn resulted in improvements in maternal and child health (MCH) and family planning (FP) acceptance. Indeed MCH/FP promotion could not have occurred without their participation in development. Since the 1960s, the Health and Women's Affairs Ministry continues to provide broad support for grass roots health care, such as strengthening the capacity of local clinics to increase coverage of health monitoring for women and children. There fore infant mortality in Sri Lanka has decreased from 47.5 in 1970 to 34 in 1980 to 19 in 1989. In addition, the total fertility rate fell from 5 in 1962-1964 to 3.4 in 1980-1982 to 2.8 in 1982-1987. The Ministry initiated its Integrated FP, Nutrition, and Parasite Control Project (IP) in 8 pilot areas in 1981. IP continues to encourage women's developed and MCH/FP at the grass roots level. In fact, FP acceptance rates increased from 31.8% in 1980 to 59% in 1989 in Nakulugamuwa and from 2.3% in 1980 to 70.5% in 1989 in Galnewa. The MCH component operating from community level clinics includes growth monitoring and immunization. Project activities include construction of latrines and wells, promotion of regular health examinations for mothers and children, FP education, counseling, nutrition promotion for children, and training programs for health staff, community volunteers, mothers' groups, and teachers. The volunteers form a link between the community and government health workers. Mothers' groups participate in school nutrition programs, home gardening, and income generation. Parasite control is consequently accomplished by community health and environmental sanitation promotion.

Simultaneous fingerprint and high-wavenumber confocal Raman spectroscopy enhances early detection of cervical precancer in vivo.

PubMed

Duraipandian, Shiyamala; Zheng, Wei; Ng, Joseph; Low, Jeffrey J H; Ilancheran, A; Huang, Zhiwei

2012-07-17

Raman spectroscopy is a vibrational spectroscopic technique capable of nondestructively probing endogenous biomolecules and their changes associated with dysplastic transformation in the tissue. The main objectives of this study are (i) to develop a simultaneous fingerprint (FP) and high-wavenumber (HW) confocal Raman spectroscopy and (ii) to investigate its diagnostic utility for improving in vivo diagnosis of cervical precancer (dysplasia). We have successfully developed an integrated FP/HW confocal Raman diagnostic system with a ball-lens Raman probe for simultaneous acquistion of FP/HW Raman signals of the cervix in vivo within 1 s. A total of 476 in vivo FP/HW Raman spectra (356 normal and 120 precancer) are acquired from 44 patients at clinical colposcopy. The distinctive Raman spectral differences between normal and dysplastic cervical tissue are observed at ~854, 937, 1001, 1095, 1253, 1313, 1445, 1654, 2946, and 3400 cm(-1) mainly related to proteins, lipids, glycogen, nucleic acids and water content in tissue. Multivariate diagnostic algorithms developed based on partial least-squares-discriminant analysis (PLS-DA) together with the leave-one-patient-out, cross-validation yield the diagnostic sensitivities of 84.2%, 76.7%, and 85.0%, respectively; specificities of 78.9%, 73.3%, and 81.7%, respectively; and overall diagnostic accuracies of 80.3%, 74.2%, and 82.6%, respectively, using FP, HW, and integrated FP/HW Raman spectroscopic techniques for in vivo diagnosis of cervical precancer. Receiver operating characteristic (ROC) analysis further confirms the best performance of the integrated FP/HW confocal Raman technique, compared to FP or HW Raman spectroscopy alone. This work demonstrates, for the first time, that the simultaneous FP/HW confocal Raman spectroscopy has the potential to be a clinically powerful tool for improving early diagnosis and detection of cervical precancer in vivo during clinical colposcopic examination.

Contraceptive use and pregnancy rates among women receiving antiretroviral therapy in Malawi: a retrospective cohort study.

PubMed

Tweya, Hannock; Feldacker, Caryl; Gugsa, Salem; Phiri, Sam

2018-02-09

In 2011, family planning (FP) services were integrated at Martin Preuss Centre (MPC), in urban Lilongwe, Malawi. To date, no previous study evaluated pregnancy rates among HIV-positive women after the integration of FP services into HIV care at the facility. In this study, we investigated whether integration of FP services into HIV clinical care led to increased use of contraceptives and decreased pregnancy rates. This was a retrospective cohort analysis of HIV-positive women from 15 to 49 years of age who accessed antiretroviral therapy (ART) services at MPC. Ascertainment of FP needs, contraceptive methods and pregnancy status were done at ART initiation, and at each ART follow-up visit. Women were offered a wide range of contraceptive methods. Outcomes of interest were contraceptive use and rate of pregnancy. Incident pregnancy was ascertained through patient self-reports during clinic consultation. Trends of contraceptive use and pregnancy rates were analyzed using chi-square (χ2). A total of 10,472 women were included in the analysis and contributed 15,700 person-years of observation. Contraceptive use among all women receiving ART increased from 28% in 2012 to 62% in 2016 (p < 0.001). A total of 501 pregnancies occurred, including 13 multiple pregnancies, resulting in an overall pregnancy rates of 3.2 per 100 person-years. Rates of pregnancy decreased from 6.8 per 100 person-years in 2012 to 1.3 per 100 person-years in 2016 (p < 0.001). Integration of FP services into HIV care resulted in increased contraceptive use and, subsequently, decreased pregnancy rates in women receiving ART. HIV programs should consider offering FP services to women who are receiving ART.

Integrated fingerprint and high wavenumber confocal Raman spectroscopy for in vivo diagnosis of cervical precancer

NASA Astrophysics Data System (ADS)

Duraipandian, Shiyamala; Zheng, Wei; Ng, Joseph; Low, Jeffrey J. H.; Ilancheran, A.; Huang, Zhiwei

2013-03-01

Raman spectroscopy is a vibrational spectroscopic technique capable of optically probing the compositional, conformational, and structural changes in the tissue associated with disease progression. The main goal of this work is to develop an integrated fingerprint (FP) and high wavenumber (HW) in vivo confocal Raman spectroscopy for simultaneous FP/HW tissue Raman spectral measurements. This work further explores the potential of integrated FP/HW Raman spectroscopy developed as a diagnostic tool for in vivo detection of cervical precancer. A total of 473 in vivo integrated FP/HW Raman spectra (340 normal and 133 precancer) were acquired from 35 patients within 1 s during clinical colposcopy. The major tissue Raman peaks are noticed around 854, 937, 1001, 1095, 1253, 1313, 1445, 1654, 2946 and 3400 cm-1, related to the molecular changes (e.g., proteins, lipids, glycogen, nucleic acids, water, etc.) that accompany the dysplastic transformation of tissue. The FP (800 - 1800 cm-1), HW (2800 - 3800 cm-1) and the integrated FP/HW Raman spectra were analyzed using partial least squares-discriminant analysis (PLS-DA) together with the leave-one patient-out, cross-validation. The developed PLS-DA classification models and receiver operating characteristics (ROC) curves for the FP, HW and integrated FP/HW spectroscopy further discloses that the performance of integrated FP/HW Raman spectroscopy is superior to that of all others in discriminating the dysplastic cervix. The results of this work indicate that the co-contributions of underlying rich biochemical information revealed by the complementary spectral modalities (FP and HW Raman) can improve the in vivo early diagnosis of cervical precancer at clinical colposcopy

Motivating women. Bangladesh.

PubMed

1996-08-01

The Integrated Family Development Program (IFDP) in Bangladesh is expanding from the original project areas in Panchdona Union and Dhalian Union into four neighboring unions under the initiative of the Family Planning Association of Bangladesh (FPAB). The JOICFP-executed project entered its second cycle this year as part of the UNFPA-supported regional Capacity Building for Sustainable Community-based Reproductive Health/Family Planning (FP) Project Emphasizing Quality of Care. The community-based project has won wide acceptance from people at the grass roots who have helped fuel its expansion into other villages. In particular, villagers have welcomed the comprehensive approach of the project which integrates a range of components such as reproductive health including FP/maternal and child health (MCH), income-generating activities, skills and literacy education for women and children and primary health care including parasite control. The success of the project also convinced the Japanese Embassy in Bangladesh to extend funding under the Japanese government's Grant Assistance for Grass Roots Cooperation Projects. With the funds, FPAB will establish a Women's Multipurpose Training Center in Panchdona Union. The sum of US$68,157 was officially handed over to FPAB on March 29 by Japanese Ambassador Yoshikazu Kaneko. The center, which is to open within this year, will contribute to improving reproductive health and promoting the empowerment of women. Once completed, it will be used for such activities as training in health care, literacy and skills for income generation for women's empowerment. full text

Postpartum family planning integration with maternal, newborn and child health services: a cross-sectional analysis of client flow patterns in India and Kenya.

PubMed

Mackenzie, Devon; Pfitzer, Anne; Maly, Christina; Waka, Charles; Singh, Gajendra; Sanyal, Abanti

2018-04-03

Maternal, newborn and child health (MNCH) services represent opportunities to integrate postpartum family planning (PPFP). Objectives were to determine levels of MNCH-family planning (FP) integration and associations between integration, client characteristics and service delivery factors in facilities that received programmatic PPFP support. Cross-sectional client flow assessment conducted during May-July 2014, over 5 days at 10 purposively selected public sector facilities in India (4 hospitals) and Kenya (2 hospitals and 4 health centres). 2158 client visits tracked (1294 India; 864 Kenya). Women aged 18 or older accessing services while pregnant and/or with a child under 2 years. PPFP/postpartum intrauterine device-Bihar, India (2012-2013); Jharkhand, India (2009-2014); Embu, Kenya (2006-2010). Maternal, infant and young child nutrition/FP integration-Bondo, Kenya (2011-2014). Proportion of visits where clients received integrated MNCH-FP services, client characteristics as predictors of MNCH-FP integration and MNCH-FP integration as predictor of length of time spent at facility. Levels of MNCH-FP integration varied widely across facilities (5.3% to 63.0%), as did proportion of clients receiving MNCH-FP integrated services by service area. Clients travelling 30-59 min were half as likely to receive integrated services versus those travelling under 30 min (OR 0.5, 95% CI 0.4 to 0.7, P<0.001). Clients receiving MNCH-FP services (vs MNCH services only) spent an average of 10.5 min longer at the facility (95% CI -0.1 to 21.9, not statistically significant). Findings suggest importance of focused programmatic support for integration by MNCH service area. FP integration was highest in areas receiving specific support. Integration does not seem to impose an undue burden on clients in terms of time spent at the facility. Clients living furthest from facilities are least likely to receive integrated services. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.

PubMed

Kaufmann, Stefan H E; Dockrell, Hazel M; Drager, Nick; Ho, Mei Mei; McShane, Helen; Neyrolles, Olivier; Ottenhoff, Tom H M; Patel, Brij; Roordink, Danielle; Spertini, François; Stenger, Steffen; Thole, Jelle; Verreck, Frank A W; Williams, Ann

2017-01-01

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development. In addition, TBVAC2020 offers portfolio management that provides selection criteria for entry, gating, and priority settings of novel vaccines at an early developmental stage. The TBVAC2020 consortium coordinated by TBVI facilitates collaboration and early data sharing between partners with the common aim of working toward the development of an effective TB vaccine. Close links with funders and other consortia with shared interests further contribute to this goal.

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

PubMed Central

Kaufmann, Stefan H. E.; Dockrell, Hazel M.; Drager, Nick; Ho, Mei Mei; McShane, Helen; Neyrolles, Olivier; Ottenhoff, Tom H. M.; Patel, Brij; Roordink, Danielle; Spertini, François; Stenger, Steffen; Thole, Jelle; Verreck, Frank A. W.; Williams, Ann; Britton, Warwick

2017-01-01

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development. In addition, TBVAC2020 offers portfolio management that provides selection criteria for entry, gating, and priority settings of novel vaccines at an early developmental stage. The TBVAC2020 consortium coordinated by TBVI facilitates collaboration and early data sharing between partners with the common aim of working toward the development of an effective TB vaccine. Close links with funders and other consortia with shared interests further contribute to this goal. PMID:29046674

"India Population Projects" in Karnataka.

PubMed

Reddy, P H; Badari, V S

1991-12-01

An overview, objectives, implementation, and research and evaluation studies of 2 India Population Projects in Karnataka are presented. The India Population Project I (IPP-I) was conducted in Karnataka and Uttar Pradesh. India Population Project III (IPP-III) took place between 1984-92 in 6 districts of Karnataka: Belgaum, Bijapur, Dharwad, Bidar, Gulbarga, and Raichur, and 4 districts in Kerala. The 6 districts in Karnataka accounted for 36% (13.2 million) of the total national population. The project cost was Rs. 713.1 million which was shared by the World Bank, and the Indian national and regional government. Due to poor past performance, these projects were undertaken to improve health and family welfare status. Specific project objectives are outlined. IPP-I included an urban component, and optimal Government of India program, and an intensive rural initiative. The urban program aimed to improved pre- and postnatal services and facilities, and the family planning (FP) in Bangalore city. The rural program was primarily to provide auxiliary nurse-midwives and hospitals and clinics, and also supplemental feeding program for pregnant and nursing mothers and children up to 2 years. The government program provided FP staff and facilities. IPP-I had 3 units to oversee building construction, to recruit staff and provide supplies and equipment, and to establish a Population Center. IPP-III was concerned with service delivery; information, education, and communication efforts (IEC) and population education; research and evaluation; and project management. Both projects contributed significantly to improving the infrastructure. A brief account of the types and kinds of studies undertaken is given. Studies were grouped into longitudinal studies of fertility, mortality, and FP; management information and evaluation systems for health and family welfare programs; experimental strategies; and other studies. Research and evaluation studies in IPP-III encompassed studies in gaps in knowledge, skills, and practice of health and FP personnel; baseline and endline surveys; and operational evaluation of the management information and evaluation system; factors affecting primary health care in Gulbarga district; evaluation of radio health lessons and the impact of the Kalyana Matha Program; and studies of vaccination and child survival and maternal mortality. Training programs were also undertaken.

China marks World Population Day. Address by Zhang Weiqing: (Excerpts).

PubMed

Zhang, W

1998-08-01

This is a summary of remarks by Minister Zhang Weiqing of China's State Family Planning Commission (SFPC) given on World Population Day in China. The world's population size has increased by 1 billion since 1987, and will reach 6 billion by 1999. As the most populous developing country in the world, China has a greater population pressure and bears a large responsibility regarding stabilization of the world's population and realization of sustainable development. China has a less developed economy and a high percentage of rural and illiterate persons, many of whom are below the poverty line. The interests of both present and future generations must be taken into account with regard to development. In addition, the modernization drive must include strategies for sustainable development and basic national policies of FP and environmental protection in order to achieve a balance among population growth, the economy, resources, and the environment. After 30 years of effort, China has succeeded in solving its population problem by integrating governmental guidance with voluntary public participation in FP. In 1997, the birthrate decreased to 16.57/1000, and the total fertility rate was below replacement level. Changes in attitude toward marriage and childbearing have occurred, as has awareness of voluntary participation in FP. However, some problems have emerged in the implementation of population and FP programs. China will carry out its programs strictly and effectively while developing the national economy. Goals include: 1) stressing the IEC program regarding contraception and regular FP management and services; 2) integrating the FP program with economic development; 3) helping the public to become well off; 4) protecting maternal and child health; 5) improving the status of women; 6) delivering reproductive services; and 7) improving social security measures. Efforts will be made to enable the public to have a more active part in implementing the FP program.

How primary care reforms influenced health indicators in Manisa district in Turkey: Lessons for general practitioners.

PubMed

Cevik, Celalettin; Sozmen, Kaan; Kilic, Bulent

2018-12-01

Turkish health reforms began in 2003 and brought some significant changes in primary care services. Few studies in Turkey compare the shift from health centres (HC) to family physicians (FP) approach, which was initiated by reforms. This study compares health status indicators during the HC period before reforms (2003-2007) and the FP period after reforms (2008-2012) in Turkey. This study encompasses time series data consisting of the results of a 10-year assessment (2003-2012) in Manisa district. All the data were obtained electronically and by month. The intersection points of the regression curves of these two periods and the beta coefficients were compared using segmented linear regression analysis. The mean number of follow-up per person/year during the HC period in infants (10.5), pregnant women (6.6) and women (1.8) was significantly higher than the mean number of follow-up during the FP period in infants (6.7), pregnant women (5.6) and women (0.9). Rates of BCG and measles vaccinations were significantly higher during the FP period; however, rates of HBV and DPT were same. The mean number of outpatient services per person/year during the FP period (3.3) was significantly higher than HC period (2.8). Within non-communicable diseases, no difference was detected for hypertension prevalence. Within communicable diseases, there was no difference for rabies suspected bites but acute haemorrhagic gastroenteritis significantly decreased. The infant mortality rate and under five-year child mortality rate significantly increased during the FP period. Primary care services should be reorganized and integrated with public health services.

Dynamic Assessment of Seismic Risk (DASR) by Multi-parametric Observations: Preliminary Results of PRIME experiment within the PRE-EARTHQUAKES EU-FP7 Project

NASA Astrophysics Data System (ADS)

Tramutoli, V.; Inan, S.; Jakowski, N.; Pulinets, S. A.; Romanov, A.; Filizzola, C.; Shagimuratov, I.; Pergola, N.; Ouzounov, D. P.; Papadopoulos, G. A.; Parrot, M.; Genzano, N.; Lisi, M.; Alparlsan, E.; Wilken, V.; Tsybukia, K.; Romanov, A.; Paciello, R.; Zakharenkova, I.; Romano, G.

2012-12-01

The integration of different observations together with the refinement of data analysis methods, is generally expected to improve our present knowledge of preparatory phases of earthquakes and of their possible precursors. This is also the main goal of PRE-EARTHQUAKES (Processing Russian and European EARTH observations for earthQUAKE precursors Studies) the FP7 Project which, to this aim, committed together, different international expertise and observational capabilities, in the last 2 years. In the learning phase of the project, different parameters (e.g. thermal anomalies, total electron content, radon concentration, etc.), measured from ground and satellite systems and analyzed by using different data analysis approaches, have been studied for selected geographic areas and specific seismic events in the past. Since July 2012 the PRIME (PRE-EARTHQUAKES Real-time Integration and Monitoring Experiment) started attempting to perform, on the base of independent observations collected and integrated in real-time through the PEG (PRE-EARTHQUAKES Geo-portal), a Dynamic Assessment of Seismic Risk (DASR) on selected geographic areas of Europe (Italy-Greece-Turkey) and Asia (Kamchatka, Sakhalin, Japan). In this paper, results so far achieved as well as the potential and opportunities they open for a worldwide Earthquake Observation System (EQuOS) - as a dedicated component of GEOSS (Global Earth Observation System of Systems) - will be presented.

Floor plate chemoattracts crossed axons and chemorepels uncrossed axons in the vertebrate brain.

PubMed

Tamada, A; Shirasaki, R; Murakami, F

1995-05-01

In the bilaterally symmetrical vertebrate CNS, all developing axons must choose between remaining on the same side of the midline or growing across it. The mechanism underlying this axonal pathfinding is, however, poorly understood. Here we demonstrate that the ventral midline floor plate (FP) chemorepels two types of ipsilaterally projecting axons, one from the alar plate and another from the basal plate in the mesencephalon. We further demonstrate that the FP chemoattracts contralaterally projecting myelencephalic as well as metencephalic axons. The FP at all axial levels displayed both chemoattractive and chemorepellent activities, suggesting that FP chemoattraction and chemorepulsion may be at work throughout the neuraxis. Chemotropic guidance by the FP may therefore play a key role in the establishment of neuronal projection laterality.

HELIO: The Heliophysics Integrated Observatory

NASA Technical Reports Server (NTRS)

Bentley, R. D.; Csillaghy, A.; Aboudarham, J.; Jacquey, C.; Hapgood, M. A.; Bocchialini, K.; Messerotti, M.; Brooke, J.; Gallagher, P.; Fox, P.;

Experimental and theoretical analysis for improved microscope design of optical projection tomographic microscopy.

PubMed

Coe, Ryan L; Seibel, Eric J

2013-09-01

We present theoretical and experimental results of axial displacement of objects relative to a fixed condenser focal plane (FP) in optical projection tomographic microscopy (OPTM). OPTM produces three-dimensional, reconstructed images of single cells from two-dimensional projections. The cell rotates in a microcapillary to acquire projections from different perspectives where the objective FP is scanned through the cell while the condenser FP remains fixed at the center of the microcapillary. This work uses a combination of experimental and theoretical methods to improve the OPTM instrument design.

Frontal Polymerization in Microgravity Summary of Research

NASA Technical Reports Server (NTRS)

Pojman, John A.

2002-01-01

The project began with frontal polymerization (FP). We studied many aspects of FP on the ground and performed two successful weeks of flying on the KC-135. The project evolved into the current flight investigation, Transient Interfacial Phenomena in Miscible Polymer Systems (TIPMPS), as we recognized that an essential question could best be studied using a non-frontal approach. We present detailed results from our ground-based work on FP, KC-135 results and the background, justification and numerical work for the TIPMPS project.

Effect of interconnection between cervical vagus trunk, epicardial fat pad on sinus node function, and atrial fibrillation.

PubMed

Zhou, Qina; Zhang, Ling; Wang, Kun; Xu, Xiaoxia; Ji, Meng; Zhang, Feng; Wang, Hongli; Hou, Yuemei

2014-03-01

The epicardial fat pad (FP) integrates the autonomic innervation between the extrinsic and intrinsic cardiac autonomic nervous system and affects atrial electrophysiology and pathophysiology. Eighteen dogs were divided into two groups: sequential ablation of sinoatrial node FP (SAN-FP) and atrioventricular node FP (AVN-FP). Sinus rate (SR), atrial fibrillation (AF) inducibility, and effective refractory period (ERP) changes during electrical stimulation of the vagus trunk were detected before and after ablation. In the SAN-FP group, the SR slowing, increasing AF inducibility, and ERP shortening that induced by vagus trunk stimulation were significantly attenuated by isolated SAN-FP ablation, compared with the same group prior to ablation (all P < 0.05). Subsequent AVN-FP ablation following SAN-FP ablation almost cannot produce further attenuation during vagus trunk stimulation, compared with isolated SAN-FP ablation (P > 0.05). In the AVN-FP group, SR slowing, increasing AF inducibility, and ERP shortening that induced by vagus trunk stimulation were completely eliminated by isolated AVN-FP ablation, compared with the same group prior to ablation (all P < 0.05). Subsequent SAN-FP ablation following AVN-FP ablation produced no further attenuation, compared with isolated AVN-FP ablation (P > 0.05). A neural pathway from the cervical vagus trunk to the sinus node and atrium runs through the SAN-FP, but eventually converges at the AVN-FP and also suggested that the AVN-FP serves as an "integration center" for the SAN-FP to modulate sinus node function. The AVN-FP may play a more critical role in the initiation and maintenance of AF. ©2013 First Affilated Hospital of Xingiang Medical University Pacing and Clinical Electrophysiology ©2013 Wiley Periodicals, Inc.

Framework Programmable Platform for the advanced software development workstation: Framework processor design document

NASA Technical Reports Server (NTRS)

Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Ackley, Keith A.; Crump, Wes; Sanders, Les

1991-01-01

The design of the Framework Processor (FP) component of the Framework Programmable Software Development Platform (FFP) is described. The FFP is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software development environment. Guided by the model, this Framework Processor will take advantage of an integrated operating environment to provide automated support for the management and control of the software development process so that costly mistakes during the development phase can be eliminated.

Systems Harmonization and Convergence - the GIGAS Approach

NASA Astrophysics Data System (ADS)

Marchetti, P. G.; Biancalana, A.; Coene, Y.; Uslander, T.

2009-04-01

0.1 Background The GIGAS1 Support Action promotes the coherent and interoperable development of the GMES, INSPIRE and GEOSS initiatives through their concerted adoption of standards, protocols, and open architectures. 0.2 Preparing for Coordinated Data Access The GMES Coordinated Data Access System is under design and implementation2. This objective has motivated the definition of the interoperability standards between the contributing missions. The following elements have been addressed with associated papers submitted to OGC: The EO Product Metadata has been based on the OGC Geographic Markup Language, addressing sensor characteristics for optical, radar and atmospheric products. Collection and service discovery: an ISO extension package for CSW ebRim has been proposed. Catalogue Service (CSW): an Earth Observation extension package of the CSW ebRim has been proposed. Feasibility Analysis and Order: an Order interface control document and an Earth Observation profile of the Sensor Planning Service have been proposed. Online Data Access: an Earth Observation profile of the Web Map Services (WMS) for visualization and evaluation purposes has been proposed. Identity (user) management: the objective in the long term is to allow for a single sign-on to the Coordinated Data Access system by users registered in the various Earth Observation ground segments by providing a federated identity across participating ground segments, exploiting OASIS standards. 0.3 The GIGAS proposed harmonization approach The approach proposed by GIGAS is based on three elements: Technology watch Comparative analysis Shaping of initiatives and standards This paper concentrates on the methodology for technology watch and comparative analysis. The complexity of the GIGAS scenario involving huge systems (i.e. GEOSS, INSPIRE, GMES etc.) entails the interaction with different heterogeneous partners, each with a specific competence, expertise and know-how. 0.3.1 Technology watch The methodology proposed is based on an RM-ODP based study supported by interoperability use cases and scenarios used to derive requirements. GIGAS will monitor the INSPIRE, GMES and GEOSS evolution and analyze the requirements, the standards, the services and the architecture, the models, the processes and the consensus mechanisms with the same elements of the other systems under analysis. activities in the fields of standard development that are part of the three initiatives. This task will provide the basis for how these three initiatives will strategically support consensus and efficient standards development going forward. architecture, specifications, innovative concepts and software developments of past or ongoing FP6/FP7 research topics. The use of an RM-ODP approach is selected as: most of the architectural approaches to be compared are based on RM-ODP, it supports distributed processing, it aims at fostering interoperability across heterogeneous systems, it tries to hide distribution to systems developers. However, as most of the systems to be considered have the characteristic of a loosely-coupled network of systems and services instead of a "distributed processing system based on interacting objects", the RM-ODP concepts are tailored for the GIGAS needs. The usage of RM-ODP for GIGAS Requirements and Technology Watch is two-fold: Architectural analysis: It is performed for all projects and initiatives. Its purpose is to identify possibilities but also major obstacles for interoperability. Furthermore, it identifies the major use cases to be analysed in more detail. Use Case Implementation Analysis: It is used to describe how selected use cases of the projects and initiatives are implemented in the different architectures. Its purpose is to identify technological gaps and concrete problems of interoperability. It is performed only for selected use cases. The output of the Technology Watch is an RM-ODP based report containing parallel analysis on the same aspects on the three initiatives integrated by analysis of relevant FP6-FP7 projects and standardization activities. 0.3.2 Comparative Analysis Based on the outcomes of the previous monitoring tasks, GIGAS undertakes a comparative analysis on solutions, requirements, architecture, models, processes and consensus mechanisms used by INSPIRE, GMES and GEOSS, taking into account the inputs from the monitoring of FP6/FP7 research projects and the ongoing standardization activities. Initiative Contact Points will insure that the overall policy framework and schedules for each of the three initiatives will be factored in. The result of the Comparative Analysis includes: A list of recommendations to GEOSS, INSPIRE and GMES to be expanded and processed in depth in the following shaping phase The identification of technological gaps to be explored in the following shaping phase. Guidelines and objectives for the architectural approach within GIGAS Analysis on the schedules of the three initiatives and on the FP6/FP7 programs and standardization activities, with identification of key milestones or intervention points.

Integration of Family Planning Services into HIV Care and Treatment Services: A Systematic Review.

PubMed

Haberlen, Sabina A; Narasimhan, Manjulaa; Beres, Laura K; Kennedy, Caitlin E

2017-06-01

Evidence on the feasibility, effectiveness, and cost-effectiveness of integrating family planning (FP) and HIV services has grown significantly since the 2004 Glion Call to Action. This systematic review adds to the knowledge base by characterizing the range of models used to integrate FP into HIV care and treatment, and synthesizing the evidence on integration outcomes among women living with HIV. Fourteen studies met our inclusion criteria, eight of which were published after the last systematic review on the topic in 2013. Overall, integration was associated with higher modern method contraceptive prevalence and knowledge, although there was insufficient evidence to evaluate its effects on unintended pregnancy or achieving safe and healthy pregnancy. Evidence for change in unmet need for FP was limited, although two of the three evaluations that measured unmet need suggested possible improvements associated with integrated services. However, improving access to FP services through integration was not always sufficient to increase the use of more effective (noncondom) modern methods among women who wanted to prevent pregnancy. Integration efforts, particularly in contexts where contraceptive use is low, must address community-wide and HIV-specific barriers to using effective FP methods alongside improving access to information, commodities, and services within routine HIV care. © 2017 The Population Council, Inc.

Pseudomonas fluorescens ATCC 13525 Containing an Artificial Oxalate Operon and Vitreoscilla Hemoglobin Secretes Oxalic Acid and Solubilizes Rock Phosphate in Acidic Alfisols

PubMed Central

Archana, G.; Naresh Kumar, G.

2014-01-01

Oxalate secretion was achieved in Pseudomonas fluorescens ATCC 13525 by incorporation of genes encoding Aspergillus niger oxaloacetate acetyl hydrolase (oah), Fomitopsis plaustris oxalate transporter (FpOAR) and Vitreoscilla hemoglobin (vgb) in various combinations. Pf (pKCN2) transformant containing oah alone accumulated 19 mM oxalic acid intracellularly but secreted 1.2 mM. However, in the presence of an artificial oxalate operon containing oah and FpOAR genes in plasmid pKCN4, Pf (pKCN4) secreted 13.6 mM oxalate in the medium while 3.6 mM remained inside. This transformant solubilized 509 μM of phosphorus from rock phosphate in alfisol which is 4.5 fold higher than the Pf (pKCN2) transformant. Genomic integrants of P. fluorescens (Pf int1 and Pf int2) containing artificial oxalate operon (plac-FpOAR-oah) and artificial oxalate gene cluster (plac-FpOAR-oah, vgb, egfp) secreted 4.8 mM and 5.4 mM oxalic acid, released 329 μM and 351 μM P, respectively, in alfisol. The integrants showed enhanced root colonization, improved growth and increased P content of Vigna radiata plants. This study demonstrates oxalic acid secretion in P. fluorescens by incorporation of an artificial operon constituted of genes for oxalate synthesis and transport, which imparts mineral phosphate solubilizing ability to the organism leading to enhanced growth and P content of V. radiata in alfisol soil. PMID:24705024

A vision and strategy for the virtual physiological human in 2010 and beyond.

PubMed

Hunter, Peter; Coveney, Peter V; de Bono, Bernard; Diaz, Vanessa; Fenner, John; Frangi, Alejandro F; Harris, Peter; Hose, Rod; Kohl, Peter; Lawford, Pat; McCormack, Keith; Mendes, Miriam; Omholt, Stig; Quarteroni, Alfio; Skår, John; Tegner, Jesper; Randall Thomas, S; Tollis, Ioannis; Tsamardinos, Ioannis; van Beek, Johannes H G M; Viceconti, Marco

2010-06-13

European funding under framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for nearly 2 years. The VPH network of excellence (NoE) is helping in the development of common standards, open-source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also helping to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by framework 6 strategy for a European physiome (STEP) project in 2006. It is now time to assess the accomplishments of the last 2 years and update the STEP vision for the VPH. We consider the biomedical science, healthcare and information and communications technology challenges facing the project and we propose the VPH Institute as a means of sustaining the vision of VPH beyond the time frame of the NoE.

A vision and strategy for the virtual physiological human in 2010 and beyond

PubMed Central

Hunter, Peter; Coveney, Peter V.; de Bono, Bernard; Diaz, Vanessa; Fenner, John; Frangi, Alejandro F.; Harris, Peter; Hose, Rod; Kohl, Peter; Lawford, Pat; McCormack, Keith; Mendes, Miriam; Omholt, Stig; Quarteroni, Alfio; Skår, John; Tegner, Jesper; Randall Thomas, S.; Tollis, Ioannis; Tsamardinos, Ioannis; van Beek, Johannes H. G. M.; Viceconti, Marco

2010-01-01

European funding under framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for nearly 2 years. The VPH network of excellence (NoE) is helping in the development of common standards, open-source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also helping to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by framework 6 strategy for a European physiome (STEP) project in 2006. It is now time to assess the accomplishments of the last 2 years and update the STEP vision for the VPH. We consider the biomedical science, healthcare and information and communications technology challenges facing the project and we propose the VPH Institute as a means of sustaining the vision of VPH beyond the time frame of the NoE. PMID:20439264

An end-users oriented methodology for enhancing the integration of knowledge on soil-water-sediment systems in River Basin Management: an illustration from the AquaTerra project.

PubMed

Merly, Corinne; Chapman, Antony; Mouvet, Christophe

2012-01-01

Research results in environmental and socio-economic sciences are often under-used by stakeholders involved in the management of natural resources. To minimise this gap, the FP6 EU interdisciplinary project AquaTerra (AT) developed an end-users' integration methodology in order to ensure that the data, knowledge and tools related to the soil-water-sediment system that were generated by the project were delivered in a meaningful way for end-users, thus improving their uptake. The methodology and examples of its application are presented in this paper. From the 408 project deliverables, 96 key findings were identified, 53 related to data and knowledge, and 43 describing advanced tools. River Basin Management (RBM) stakeholders workshops identified 8 main RBM issues and 25 specific stakeholders' questions related to RBM which were classified into seven groups of cross-cutting issues, namely scale, climate change, non-climatic change, the need for systemic approaches, communication and participation, international and inter-basin coordination and collaboration, and the implementation of the Water Framework Directive. The integration methodology enabled an assessment of how AT key findings meet stakeholders' demands, and for each main RBM issue and for each specific question, described the added-value of the AT project in terms of knowledge and tools generated, key parameters to consider, and recommendations that can be made to stakeholders and the wider scientific community. Added value and limitations of the integration methodology and its outcomes are discussed and recommendations are provided to further improve integration methodology and bridge the gaps between scientific research data and their potential uptake by end-users.

Tissue microarrays and digital image analysis.

PubMed

Ryan, Denise; Mulrane, Laoighse; Rexhepaj, Elton; Gallagher, William M

2011-01-01

Tissue microarrays (TMAs) have recently emerged as very valuable tools for high-throughput pathological assessment, especially in the cancer research arena. This important technology, however, has yet to fully penetrate into the area of toxicology. Here, we describe the creation of TMAs representative of samples produced from conventional toxicology studies within a large-scale, multi-institutional pan-European project, PredTox. PredTox, short for Predictive Toxicology, formed part of an EU FP6 Integrated Project, Innovative Medicines for Europe (InnoMed), and aimed to study pre-clinically 16 compounds of known liver and/or kidney toxicity. In more detail, TMAs were constructed from materials corresponding to the full face sections of liver and kidney from rats treated with different drug candidates by members of the consortium. We also describe the process of digital slide scanning of kidney and liver sections, in the context of creating an online resource of histopathological data.

Weird Project: E-Health Service Improvement Using WiMAX

NASA Astrophysics Data System (ADS)

Cimmino, Antonio; Casali, Fulvio; Mambretti, Cinzia

Today the major obstacle to massive deployment of telemedicine applications are the security issues related to the exchange of real time information between different elements that are not at fixed locations. WiMAX, the new standard for wireless communications, is one of the most promising technologies for broadband access in a fixed and mobile environment and it is expected to overcome the above mentioned obstacle. The FP6-WEIRD [1] (WiMax Extension to Isolated Remote Data networks) project has: analysed how this technology can guarantee secure real time data transmission between mobile elements, built some successful demonstrations and paved the way to future commercial applications. This paper in particular describes: main promising e-health applications that WiMax would enable; the technological highlights and the main challenges that WiMax has to face in e-health applications such as accounting, privacy, security, data integrity; the way in which the WEIRD project 0 has studied the wireless access to medical communities and equipment in remote or impervious areas. 0 0; some envisaged implementations.

A novel injection strategy of flurbiprofen axetil by inhibiting protein binding with 6-methoxy-2-naphthylacetic acid.

PubMed

Ogata, Kenji; Takamura, Norito; Tokunaga, Jin; Ikeda, Tetsuya; Setoguchi, Nao; Tanda, Kazuhiro; Yamasaki, Tetsuo; Nishio, Toyotaka; Kawai, Keiichi

2016-04-01

Flurbiprofen axetil (FPA) is an injection product and a prodrug of a non-steroidal anti-inflammatory drug (NSAID). After injection, it is rapidly hydrolyzed to the active form, flurbiprofen (FP). Since frequent injections of FPA can lead to abnormal physiology, an administration strategy is necessary to ensure there is enhancement of the analgesic efficiency of FP after a single dose and to reduce the total number of doses. FP strongly binds to site II of albumin, and thus the free (unbound) FP concentration is low. This study focused on 6-methoxy-2-naphthylacetic acid (6-MNA), the active metabolite of nabumetone (a prodrug of NSAID). We performed ultrafiltration experiments and pharmacokinetics analysis in rats to investigate whether the inhibitory effect of 6-MNA on FP binding to albumin increased the free FP concentration in vitro and in vivo. Results indicated that 6-MNA inhibited the binding of FP to albumin competitively. When 6-MNA was injected in rats, there was a significant increase in the free FP concentration and the area under concentration-time curve (AUC) calculated from the free FP concentration, while there was a significant decrease in the total (bound + free) FP concentration and the AUC calculated from the total FP concentration. These findings indicate that 6-MNA inhibits the protein binding of FP in vivo. This suggests that the frequency of FPA injections can be reduced when administered with nabumetone, as there is increase in the free FP concentration associated with pharmacological effect.

EC FP6 Enviro-RISKS project outcomes in area of Earth and Space Science Informatics applications

NASA Astrophysics Data System (ADS)

Gordov, E. P.; Zakarin, E. A.

2009-04-01

Nowadays the community acknowledged that to understand dynamics of regional environment properly and perform its assessment on the base of monitoring and modeling more strong involvement of information-computational technologies (ICT) is required, which should lead to development of information-computational infrastructure as an inherent part of such investigations. This paper is based on the Report&Recommendations (www.dmi.dk/dmi/sr08-05-4.pdf) of the Enviro-RISKS (Man-induced Environmental Risks: Monitoring, Management and Remediation of Man-made Changes in Siberia) Project Thematic expert group for Information Systems, Integration and Synthesis Focus and presents results of activities of Project Partners in area of Information Technologies for Environmental Sciences development and usage. Approaches used the web-based Information Technologies and the GIS-based Information Technologies are described and a way to their integration is outlined. In particular, developed in course of the Project carrying out Enviro-RISKS web portal and its Climate site (http://climate.risks.scert.ru/), providing an access to interactive web-system for regional climate assessment on the base of standard meteorological data archives, which is a key element of the information-computational infrastructure of the Siberia Integrated Regional Study (SIRS), is described in details as well as developed on the base of GIS technology system for monitoring and modeling air and water pollutions transport and transformations. The later is quite useful for practical applications realization of geoinformation modeling, in which relevant mathematical models are plunged into GIS and all the modeling and analysis phases are accomplished in the informational sphere, based on the real data including those coming from satellites. Major efforts currently are undertaken in attempt to integrate GIS based environmental applications with web accessibility, computing power and data interoperability thus to exploit completely huge potential of web bases technologies. In particular, development of a region devoted web portal using approached suggested by the Open Geospatial Consortium has been started recently. The state of the art of the information-computational infrastructure in the targeted region is quite a step in the process of development of a distributed collaborative information-computational environment to support multidisciplinary investigations of Earth regional environment, especially those required meteorology, atmospheric pollution transport and climate modeling. Established in process of the Project carrying out cooperative links, new Partners initiatives, and gained expertise allow us to hope that this infrastructure rather soon will make significant input into understanding regional environmental processes in their relationships with Global Change. In particular, this infrastructure will play a role of the 'underlying mechanics' of the research work, leaving the earth scientists to concentrate on their investigations as well as providing the environment to make research results available and understandable to everyone. Additionally to the core FP6 Enviro-RISKS project (INCO-CT-2004-013427) support this activity was partially supported by SB RAS Integration Project 34, SB RAS Basic Program Project 4.5.2.2 and APN Project CBA2007-08NSY. Valuable input into the expert group work and elaborated outcomes of Profs. V. Lykosov and A. Starchenko, Drs. D. Belikov, , M. Korets, S. Kostrykin, B. Mirkarimova, I. Okladnikov, , A. Titov and A. Tridvornov is acknowledged.

Integration and Optimization of Alternative Sources of Energy in a Remote Region

NASA Astrophysics Data System (ADS)

Berberi, Pellumb; Inodnorjani, Spiro; Aleti, Riza

2010-01-01

In a remote coastal region supply of energy from national grid is insufficient for a sustainable development. Integration and optimization of local alternative renewable energy sources is an optional solution of the problem. In this paper we have studied the energetic potential of local sources of renewable energy (water, solar, wind and biomass). A bottom-up energy system optimization model is proposed in order to support planning policies for promoting the use of renewable energy sources. A software, based on multiple factors and constrains analysis for optimization energy flow is proposed, which provides detailed information for exploitation each source of energy, power and heat generation, GHG emissions and end-use sectors. Economical analysis shows that with existing technologies both stand alone and regional facilities may be feasible. Improving specific legislation will foster investments from Central or Local Governments and also from individuals, private companies or small families. The study is carried on the frame work of a FP6 project "Integrated Renewable Energy System."

Family medicine residency program directors' plans to incorporate maintenance of certification into residency training: a CERA survey.

PubMed

Peterson, Lars E; Blackburn, Brenna; Phillips, Robert L; Mainous, Arch G

2014-04-01

Participation in Maintenance of Certification for Family Physicians (MC-FP) is now a requirement for residents to take the American Board of Family Medicine (ABFM) certification examination. The objective of this study was to determine baseline use of MC-FP products prior to this requirement and assess how family medicine residency program directors (FMPD) intended to integrate MC-FP into residency education. We used the CERA platform to survey FMPDs. In addition to the core CERA demographic questions, we asked about the use of MC-FP in residency, how FMPDs intended to incorporate MC-FP, and how useful they believe MC-FP will be for resident evaluation. Additionally, we compared select results with the ABFM administrative database. A total of 224 FMPDs responded, for a 50.6% response rate. There was agreement between CERA and ABFM data on the percentage of residencies already using Part 4 modules (39.3% versus 38.8%) but not Part 2 modules (24.7% versus 62.8%). Group MC-FP activities were the preferred method for both Part 2 (45.0%) and Part 4 (54.4%). Most FMPDs agreed that MC-FP will be effective in teaching quality improvement and assessing competencies. Respondents from dually accredited programs were more likely to have used Part 4, but not Part 2, activities prior to 2012. Prior to MC-FP becoming a requirement in residency, a sizeable minority of residencies were already using these tools for education. Assessment of competencies will be crucial in the Next Accreditation System, and MC-FP may help in tracking clinical development over a physician's career.

Comparative development of knowledge-based bioeconomy in the European Union and Turkey.

PubMed

Celikkanat Ozan, Didem; Baran, Yusuf

2014-09-01

Biotechnology, defined as the technological application that uses biological systems and living organisms, or their derivatives, to create or modify diverse products or processes, is widely used for healthcare, agricultural and environmental applications. The continuity in industrial applications of biotechnology enables the rise and development of the bioeconomy concept. Bioeconomy, including all applications of biotechnology, is defined as translation of knowledge received from life sciences into new, sustainable, environment friendly and competitive products. With the advanced research and eco-efficient processes in the scope of bioeconomy, more healthy and sustainable life is promised. Knowledge-based bioeconomy with its economic, social and environmental potential has already been brought to the research agendas of European Union (EU) countries. The aim of this study is to summarize the development of knowledge-based bioeconomy in EU countries and to evaluate Turkey's current situation compared to them. EU-funded biotechnology research projects under FP6 and FP7 and nationally-funded biotechnology projects under The Scientific and Technological Research Council of Turkey (TUBITAK) Academic Research Funding Program Directorate (ARDEB) and Technology and Innovation Funding Programs Directorate (TEYDEB) were examined. In the context of this study, the main research areas and subfields which have been funded, the budget spent and the number of projects funded since 2003 both nationally and EU-wide and the gaps and overlapping topics were analyzed. In consideration of the results, detailed suggestions for Turkey have been proposed. The research results are expected to be used as a roadmap for coordinating the stakeholders of bioeconomy and integrating Turkish Research Areas into European Research Areas.

Population remains top priority for China.

PubMed

Li, H

1998-04-01

China, whose population was 430 million in 1840, is facing a population total of 1.3 billion in 2000. Population increased rapidly in the country during the 1950s, but early efforts at population control were abandoned from the start of the Cultural Revolution in 1966 until the 1970s. Today, the importance of family planning (FP) is recognized throughout Chinese society. With 20 million newborns adding 13 million people to the population each year, controlling the population increase will remain a top priority of China's population policy. Other priorities include 1) increasing the quality of life of the population by improving health, promoting literacy, and developing human resources; 2) facing the impact of population aging; 3) struggling to overcome the poverty experienced by 50 million people; and 4) dealing with the imbalanced sex ratio of newborns. China has been attempting to institute strategies to implement the Program of Action adopted by the 1994 International Conference on Population and Development and is attempting to adopt an integrated approach to population programs that combines FP with development measures and the delivery of multiple services to enhance reproductive health. Since 1984, China has worked with Japan's JOICFP on an Integrated Project that offers FP, maternal and child health services, and parasite control.

The quest for modernisation of traditional Chinese medicine

PubMed Central

2013-01-01

Traditional Chinese medicine (TCM) is an integral part of mainstream medicine in China. Due to its worldwide use, potential impact on healthcare and opportunities for new drug development, TCM is also of great international interest. Recently, a new era for modernisation of TCM was launched with the successful completion of the Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era (GP-TCM) project, the European Union’s Seventh Framework Programme (FP7) coordination action on TCM research. This 3.5-year project that involved inputs from over 200 scientists resulted in the production of 20 editorials and in-depth reviews on different aspects of TCM that were published in a special issue of Journal of Ethnopharmacology (2012; volume 140, issue 3). In this narrative review, we aim to summarise the findings of the FP7 GP-TCM project and highlight the relevance of TCM to modern medicine within a historical and international context. Advances in TCM research since the 1950s can be characterised into three phases: Phase I (1950s-1970s) was fundamental for developing TCM higher education, research and hospital networks in China; Phase II (1980s-2000s) was critical for developing legal, economic and scientific foundations and international networks for TCM; and Phase III (2011 onwards) is concentrating on consolidating the scientific basis and clinical practice of TCM through interdisciplinary, interregional and intersectoral collaborations. Taking into account the quality and safety requirements newly imposed by a globalised market, we especially highlight the scientific evidence behind TCM, update the most important milestones and pitfalls, and propose integrity, integration and innovation as key principles for further modernisation of TCM. These principles will serve as foundations for further research and development of TCM, and for its future integration into tomorrow’s medicine. PMID:23763836

European Union investment and countries' involvement in mental health research between 2007 and 2013.

PubMed

Hazo, J-B; Gervaix, J; Gandré, C; Brunn, M; Leboyer, M; Chevreul, K

2016-08-01

This study aimed to estimate the commitment to mental health research by the European Union (EU) through the 7th framework (FP7) and the competitiveness and innovation (CIP) programmes during the 2007-2013 period. Research projects dedicated or partially related to mental health were identified using keywords in the CORDIS database that inventories all FP7 and CIP research projects. We then contacted projects' principal investigators to access the budget breakdown by country and performed an imputation of the distribution of funding between countries based on projects' and participants' characteristics where information was missing. Among the 25 783 research projects funded by the FP7 and the CIP, 215 (0.8%) were specifically dedicated to mental health and 170 (0.7%) were partially related to mental health. They received €607.1 million representing 1.4% of FP7 total funding. Within the FP7-Health subprogramme, the projects represented 5.2% of funding. Important variations appeared across EU countries both for raw funding, which varied between €0 and €77M, and for funding per 100 inhabitants, which varied between €0 and €293. EU funding of mental health research does not match the burden incurred by mental disorders and must be increased in the next framework programme. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

People are satisfied with it.

PubMed

Hata, K

1992-08-01

The success of the integrated Family Planning (FP) and Parasite Control Project (IP) of Indonesia is discussed in terms of the government's view, the major characteristics of IP, the major problem, future funding sources, the purposes of community participation, obstacles encountered, and impact. Ministry policymakers consider IP effective and desirable, and suggest IP in remote areas with poor infrastructure such as Lombok in West Nusa Tenggara Province. Health is improved for parents and children initially. The project is self-reliant with small, affordable fees. Support has come from the Indonesian Planned Parenthood Association and Kusuma Buana Foundation; although external financial assistance has ceased, expansion is possible with the income generated. The Jakarta Municipal government may pick up the cost of implementing it through the public health center Pukesmas, either with existing project staff or local staff in collaboration with IP staff. The government is not ready to implement it because control of intestinal parasites is of low priority. Major problems are the uneven performance particularly in IP bases in Jakarta, which is attributed to lack of concern by managers for community health conditions. Community participation is important because people are eager to learn how to prevent the parasitic invasions after being successfully treated. When success in cleaning houses and toilets and lower incidence of infection is accomplished, then people trust and use the health services more. Obstacles have been the cost of building hygienic latrines and access to safe and potable water, particularly in slum areas of Jakarta, and changing institutional representation on the IP project National Coordinating Forum, the IP policy making group, and officials from government FP and Health and Education Departments. Government officials need to understand the intricacies of how IP operates. Evaluation is difficult with measures such as the fertility rate or infant mortality rate. Project staff are satisfied with the increase in health consciousness of clients, and the use of paid services. A study by the Forum found that FP participation among the target community increased compared with baseline data, but FP information is available from multiple sources in Jakarta and it would be presumptuous to believe that community participation was solely due to IP.

Engaging community organizations in falls prevention for older adults: Moving from research to action.

PubMed

Markle-Reid, Maureen F; Dykeman, Catherine S; Reimer, Holly D; Boratto, Lorna J; Goodall, Carol E; McGugan, Jennifer L

2015-04-29

Falls prevention (FP) evidence abounds but falls rates remain relatively unaffected. This study aimed to explore community service providers' use of evidence-based FP interventions, attitudes toward implementation, knowledge and capacity for FP engagement, collaboration in FP, and organizational readiness to implement evidence. To our knowledge, this is the first study exploring the potential for broader integration of FP throughout communities. A purposive sampling of providers (n = 84), in varied roles within diverse senior-serving community organizations (both health and non-health sectors) across disparate geographies, completed a structured survey as part of a larger mixed methods study. Nearly all (90%) reported already implementing at least one evidence-based FP practice. The majority indicated that falls were preventable (82%) and a top concern for older adults (75%), and that FP would be beneficial to their clients (75%). There were, however, notable differences between health and non-health sectors in their: confidence in providing FP activities (86% vs. 47%), desire for future collaboration (86% vs. 56%) and already knowing how best to provide FP activities (49% vs. 36%). Only some (21%) perceived that staff to a great extent had the necessary knowledge and skills, and few (10%) perceived that available resources could support FP activities. Community service providers generally supported FP, but resources limited implementation, particularly in non-health sectors. Translating FP evidence to better fit community settings, and fostering collaboration to bridge resource gaps, suggest a public health role in the broader integration of FP within and across community sectors.

Population and reproductive health in National Adaptation Programmes of Action (NAPAs) for climate change in Africa.

PubMed

Mutunga, Clive; Hardee, Karen

2010-12-01

This paper reviews 44 National Adaptation Programmes of Action (NAPAs) to assess the NAPA process and identify the range of interventions included in countries' priority adaptation actions and highlight how population issues and reproductive health/family planning (RH/FP) are addressed as part of the adaptation agenda. A majority of the 44 NAPAs identify rapid population growth as a key component of vulnerability to climate change impacts. However, few chose to prioritise NAPA funds for family planning/reproductive health programmes. The paper emphasizes the need to translate the recognition of population pressure as a factor related to countries' ability to adapt to climate change into relevant project activities. Such projects should include access to RH/FP, in addition to other strategies such as girls' education and women's empowerment that lead to lower fertility. Attention to population and integrated strategies should be central and aligned to longer-term national adaptation plans and strategies.

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk.

PubMed

Daneshian, Mardas; Kamp, Hennicke; Hengstler, Jan; Leist, Marcel; van de Water, Bob

2016-05-01

The integrated European project, EU-ToxRisk, proudly sees itself as "flagship" exploring new alternative-to-animal approaches to chemical safety evaluation. It promotes mechanism-based toxicity testing and risk assessment according to the principles laid down for toxicology for the twenty-first century. The project was officially launched in January 2016 with a kickoff meeting in Egmond aan Zee, the Netherlands. Over 100 scientists representing academia and industry as well as regulatory authorities attended the inaugural meeting. The project will integrate advances in in vitro and in silico toxicology, read-across methods, and adverse outcome pathways. EU-ToxRisk will continue to make use of the case study strategy deployed in SEURAT-1, a FP7 initiative ended in December 2015. Even though the development of new non-animal methods is one target of EU-ToxRisk, the project puts special emphasis on their acceptance and implementation in regulatory contexts. This €30 million Horizon 2020 project involves 38 European partners and one from the USA. EU-ToxRisk aims at the "development of a new way of risk assessment."

The implementation of the Open Access paradigm to the EC-FP7 MED-SUV (Mediterranean Supersite Volcanoes) project

NASA Astrophysics Data System (ADS)

Puglisi, Giuseppe; Brito, Fabrice; Caumont, Hervé; D'Auria, Luca; Fernandez, José; Mazzetti, Paolo; Mathieu, Pierre Philippe; Nativi, Stefano; Papeschi, Fabrizio; Pepe, Antonio; Reitano, Danilo; Sangianantoni, Agata; Scarpato, Giovanni; Spampinato, Letizia

2016-04-01

The overall goal of the EC-FP7 Mediterranean Supersite Volcanoes (MED-SUV) project is to apply the rationale of the Supersites GEO initiative to Campi Flegrei/Vesuvius and Mt. Etna to reduce the volcanic risk, by improving the understanding of the underlying geophysical processes, through the integration and sharing of the in-situ and Earth Observation (EO) data sets and the implementation of new instruments and monitoring systems. The project involves 24 EU and no-EU partners, including research and academic institutions, space agencies and SMEs. In this framework, the application of the Open Access paradigm has offered the opportunity to study and apply practical solutions concerning the data management (i.e. data polices, foreground exploitation and sustainability), intellectual property rights (i.e., ownership, licences, agreements) and technical issues (i.e., design and implementation of an interoperability e-infrastructure, access systems, etc.). This contribution presents pro and cons encountered in the project, as well as the main outcomes of the implementation of the Open Access to the Italian Supersites. This experience will be exploited in the building of international research infrastructures, such as EPOS, and the outcomes of the project will contribute to foster the Open Access to the research data in a wide context, as the GEO-GEOSS framework.

Comparison of a flexible versus a rigid breast compression paddle: pain experience, projected breast area, radiation dose and technical image quality.

PubMed

Broeders, Mireille J M; Ten Voorde, Marloes; Veldkamp, Wouter J H; van Engen, Ruben E; van Landsveld-Verhoeven, Cary; 't Jong-Gunneman, Machteld N L; de Win, Jos; Greve, Kitty Droogh-de; Paap, Ellen; den Heeten, Gerard J

2015-03-01

To compare pain, projected breast area, radiation dose and image quality between flexible (FP) and rigid (RP) breast compression paddles. The study was conducted in a Dutch mammographic screening unit (288 women). To compare both paddles one additional image with RP was made, consisting of either a mediolateral-oblique (MLO) or craniocaudal-view (CC). Pain experience was scored using the Numeric Rating Scale (NRS). Projected breast area was estimated using computer software. Radiation dose was estimated using the model by Dance. Image quality was reviewed by three radiologists and three radiographers. There was no difference in pain experience between both paddles (mean difference NRS: 0.08 ± 0.08, p = 0.32). Mean radiation dose was 4.5 % lower with FP (0.09 ± 0.01 p = 0.00). On MLO-images, the projected breast area was 0.79 % larger with FP. Paired evaluation of image quality indicated that FP removed fibroglandular tissue from the image area and reduced contrast in the clinically relevant retroglandular area at chest wall side. Although FP performed slightly better in the projected breast area, it moved breast tissue from the image area at chest wall side. RP showed better contrast, especially in the retroglandular area. We therefore recommend the use of RP for standard MLO and CC views.

EU-funded malaria research under the 6th and 7th Framework Programmes for research and technological development.

PubMed

Holtel, Andreas; Troye-Blomberg, Marita; Penas-Jimenez, Inmaculada

2011-01-14

While malaria research has traditionally been strong in Europe, targeted and sustained support for cooperative malaria research at EU level, namely through the EU's 6th and 7th Framework Programmes for research and technological development, FP6 (2002-2006) and FP7 (2007-2013), has boosted both impact and visibility of European malaria research. Most of the European malaria research community is now organized under a number of comprehensive and complementary research networks and projects, assembled around four key areas: (1) fundamental research on the malaria parasite and the disease, (2) development of new malaria drugs, (3) research and development of a malaria vaccine, and (4) research to control the malaria-transmitting mosquito vector. Considerable efforts were undertaken to ensure adequate participation of research groups from disease-endemic countries, in particular from Africa, with the long-term aim to strengthen cooperative links and research capacities in these countries. The concept of organizing European research through major strategic projects to form a "European Research Area" (ERA) was originally developed in the preparation of FP6, and ERA formation has now turned into a major EU policy objective explicitly inscribed into the Lisbon Treaty. EU-funded malaria research may serve as a showcase to demonstrate how ERA formation can successfully be implemented in a given area of science when several surrounding parameters converge to support implementation of this strategic concept: timely coincidence of political stimuli, responsive programming, a clearly defined--and well confined--area of research, and the readiness of the targeted research community who is well familiar with transnational cooperation at EU level. Major EU-funded malaria projects have evolved into thematic and organizational platforms that can collaborate with other global players. Europe may thus contribute more, and better, to addressing the global research agenda for malaria.

SBDN: an information portal on small bodies and interplanetary dust inside the Europlanet Research Infrastructure

NASA Astrophysics Data System (ADS)

Turrini, Diego; de Sanctis, Maria Cristina; Carraro, Francesco; Fonte, Sergio; Giacomini, Livia; Politi, Romolo

In the framework of the Sixth Framework Programme (FP6) for Research and Technological Development of the European Community, the Europlanet project started the Integrated and Distributed Information Service (IDIS) initiative. The goal of this initiative was to "...offer to the planetary science community a common and user-friendly access to the data and infor-mation produced by the various types of research activities: earth-based observations, space observations, modelling and theory, laboratory experiments...". Four scientific nodes, repre-sentative of a significant fraction of the scientific themes covered by planetary sciences, were created: the Interiors and Surfaces node, the Atmospheres node, the Plasma node and the Small Bodies and Dust node. The original Europlanet program evolved into the Europlanet Research Infrastructure project, funded by the Seventh Framework Programme (FP7) for Research and Technological Development, and the IDIS initiative has been renewed with the addiction of a new scientific node, the Planetary Dynamics node. Here we present the Small Bodies and Dust node (SBDN) and the services it already provides to the scientific community, i.e. a searchable database of resources related to its thematic domains, an online and searchable cat-alogue of emission lines observed in the visible spectrum of comet 153P/2002 C1 Ikeya-Zhang supplemented by a visualization facility, a set of models of the simulated evolution of comet 67P/Churyumov-Gerasimenko with a particular focus on the effects of the distribution of dust and a information system on meteors through the Virtual Meteor Observatory. We will also introduce the new services that will be implemented and made available in the course of the Europlanet Research Infrastructure project.

A vision and strategy for the virtual physiological human: 2012 update

PubMed Central

Hunter, Peter; Chapman, Tara; Coveney, Peter V.; de Bono, Bernard; Diaz, Vanessa; Fenner, John; Frangi, Alejandro F.; Harris, Peter; Hose, Rod; Kohl, Peter; Lawford, Pat; McCormack, Keith; Mendes, Miriam; Omholt, Stig; Quarteroni, Alfio; Shublaq, Nour; Skår, John; Stroetmann, Karl; Tegner, Jesper; Thomas, S. Randall; Tollis, Ioannis; Tsamardinos, Ioannis; van Beek, Johannes H. G. M.; Viceconti, Marco

2013-01-01

European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595–2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally. PMID:24427536

A vision and strategy for the virtual physiological human: 2012 update.

PubMed

Hunter, Peter; Chapman, Tara; Coveney, Peter V; de Bono, Bernard; Diaz, Vanessa; Fenner, John; Frangi, Alejandro F; Harris, Peter; Hose, Rod; Kohl, Peter; Lawford, Pat; McCormack, Keith; Mendes, Miriam; Omholt, Stig; Quarteroni, Alfio; Shublaq, Nour; Skår, John; Stroetmann, Karl; Tegner, Jesper; Thomas, S Randall; Tollis, Ioannis; Tsamardinos, Ioannis; van Beek, Johannes H G M; Viceconti, Marco

2013-04-06

European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595-2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.

Family planning offered in local welfare offices.

PubMed

1998-04-01

This article describes expanded access to family planning (FP) services through community welfare offices in Washington state, US. The government aim is to decrease unintended pregnancies and to help families achieve self-sufficiency. The staff must be sensitive and respectful of clients served. The team effort includes contacting clients in other community locations to offer FP education. The approach is characterized as "1-stop shopping" that includes FP, welfare, access to jobs, training, and medical coupons. Preventing unintended pregnancies is cost effective. A state (90%) investment of $40/person for contraceptives is good business compared to $400/person as a 50/50 state/federal investment in prenatal and delivery costs. The program began in 1992, by educating staff members in community services offices (CSOs) about FP issues. In 1994, the program hired registered nurses and nurse practitioners at CSOs to provide FP services. Almost all CSOs now have nurses, and there are 8 full exam clinics. A resource handbook for CSO workers and FP nurses was compiled by state and local FP personnel. CSOs typically assign 1 staff member to FP, usually on a part time basis. Close collaboration between nurses and CSO workers usually involves more creative strategies and outreach projects. For example, in 1 CSO in Washington, the FP worker offers contraceptive counseling, pregnancy tests, and sexually transmitted disease prevention. Contraceptives are provided at a separate time with local private providers or at health department clinics. CSOs continue to provide counseling regardless of referrals to private clinics. The project is growing and forming collaborations with other FP groups. These 1-stop sites offer accessible, familiar, and comfortable services.

Substantial gains with existing resources: the Tongan experience.

PubMed

Tufui, V

1986-11-01

Tonga has a relatively high rate of population growth that is moderated by emigration. There has been a decline in fertility, however. Family planning was introduced in Tonga during the 1950s. The Tongan Family Planning Association (TFPA) is a non-government organization established and recognized by the Tongan government. The Japanese Organization for International Cooperation in Family Planning (JOICEP) approved of and funded an integrated TFPA-JOICEP project on health education and family planning motivation as well as a national seminar. TFPA projects for 1986 include: youth development; women's development; men's development; and health education, family planning motivational integrated approaches in development and family planning. A station wagon serves as a mobile clinic. A doctor and his staff hold clinics or meet with women in the villages to demonstrate contraceptive use and to discuss reproduction and fertilization. Other organizations which provide FP services are: the Government Health Services and the MCH Department; the Catholic Mission; and the Seventh Day Adventist Mission. Tongan health services are largely a governmental responsibility and are provided free of charge. There are 4 main hospitals and 6 health centers with a total of 325 hospital beds.

Projecting the Water Footprint Associated with Shale Resource Production: Eagle Ford Shale Case Study.

PubMed

Ikonnikova, Svetlana A; Male, Frank; Scanlon, Bridget R; Reedy, Robert C; McDaid, Guinevere

2017-12-19

Production of oil from shale and tight reservoirs accounted for almost 50% of 2016 total U.S. production and is projected to continue growing. The objective of our analysis was to quantify the water outlook for future shale oil development using the Eagle Ford Shale as a case study. We developed a water outlook model that projects water use for hydraulic fracturing (HF) and flowback and produced water (FP) volumes based on expected energy prices; historical oil, natural gas, and water-production decline data per well; projected well spacing; and well economics. The number of wells projected to be drilled in the Eagle Ford through 2045 is almost linearly related to oil price, ranging from 20 000 wells at $30/barrel (bbl) oil to 97 000 wells at $100/bbl oil. Projected FP water volumes range from 20% to 40% of HF across the play. Our base reference oil price of $50/bbl would result in 40 000 additional wells and related HF of 265 × 10 9 gal and FP of 85 × 10 9 gal. The presented water outlooks for HF and FP water volumes can be used to assess future water sourcing and wastewater disposal or reuse, and to inform policy discussions.

Human capital needs - teaching, training and coordination for nuclear fuel cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Retegan, T.; Ekberg, C.; John, J.

Human capital is the accumulation of competencies, knowledge, social and creativity skills and personality attributes, which are necessary to perform work so as to produce economic value. In the frame of the nuclear fuel cycle, this is of paramount importance that the right human capital exists and in Europe this is fostered by a series of integrated or directed projects. The teaching, training and coordination will be discussed in the frame of University curricula with examples from several programs, like e.g. the Master of Nuclear Engineering at Chalmers University, Sweden and two FP7 EURATOM Projects: CINCH - a project formore » cooperation in nuclear chemistry - and ASGARD - a research project on advanced or novel nuclear fuels and their reprocessing issues for generation IV reactors. The integration of the university curricula in the market needs but also the anchoring in the research and future fuel cycles will be also discussed, with examples from the ASGARD project. (authors)« less

MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite-allergic rhinitis.

PubMed

Kortekaas Krohn, I; Callebaut, I; Alpizar, Y A; Steelant, B; Van Gerven, L; Skov, P S; Kasran, A; Talavera, K; Wouters, M M; Ceuppens, J L; Seys, S F; Hellings, P W

2018-05-01

Nasal hyperreactivity (NHR) is an important clinical feature of allergic rhinitis (AR). The efficacy of MP29-02 (azelastine hydrochloride (AZE) and fluticasone propionate [FP]) nasal spray on local inflammatory mediators and NHR in AR is unknown. We tested if MP29-02 decreases inflammatory mediators and NHR in AR and if this effect is due to restoration of nasal epithelial barrier function. A 4-week double-blinded placebo-controlled trial with MP29-02 treatment was conducted in 28 patients with house dust mite (HDM) AR. The presence of NHR was evaluated by measuring reduction in nasal flow upon cold dry air exposure. The effects of AZE ± FP on barrier integrity and airway inflammation were studied in a murine model of HDM-induced NHR and on reduced activation of murine sensory neurons and human mast cells. MP29-02 but not placebo reduced NHR (P < .0001 vs P = .21), levels of substance P (P = .026 vs P = .941), and β-hexosaminidase (P = .036 vs P = .632) in human nasal secretions. In wild-type C57BL6 mice, the reduction in β-hexosaminidase levels (P < .0001) by AZE + FP treatment upon HDM challenge was found in parallel with a decreased transmucosal passage (P = .0012) and completely reversed eosinophilic inflammation (P = .0013). In vitro, repeated applications of AZE + FP desensitized sensory neurons expressing the transient receptor potential channels TRPA1 and TRPV1. AZE + FP reduced MC degranulation to the same extent as AZE alone. MP29-02 treatment reduces inflammatory mediators and NHR in AR. The effects of AZE + FP on MC degranulation, nasal epithelial barrier integrity, and TRP channels provide novel insights into the pathophysiology of allergic rhinitis. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Data harmonization of environmental variables: from simple to general solutions

NASA Astrophysics Data System (ADS)

Baume, O.

2009-04-01

European data platforms often contain measurements from different regional or national networks. As standards and protocols - e.g. type of measurement devices, sensors or measurement site classification, laboratory analysis and post-processing methods, vary between networks, discontinuities will appear when mapping the target variable at an international scale. Standardisation is generally a costly solution and does not allow classical statistical analysis of previously reported values. As an alternative, harmonization should be envisaged as an integrated step in mapping procedures across borders. In this paper, several harmonization solutions developed under the INTAMAP FP6 project are presented. The INTAMAP FP6 project is currently developing an interoperable framework for real-time automatic mapping of critical environmental variables by extending spatial statistical methods to web-based implementations. Harmonization is often considered as a pre-processing step in statistical data analysis workflow. If biases are assessed with little knowledge about the target variable - in particular when no explanatory covariate is integrated, a harmonization procedure along borders or between regionally overlapping networks may be adopted (Skøien et al., 2007). In this case, bias is estimated as the systematic difference between line or local predictions. On the other hand, when covariates can be included in spatial prediction, the harmonization step is integrated in the whole model estimation procedure, and, therefore, is no longer an independent pre-processing step of the automatic mapping process (Baume et al., 2007). In this case, bias factors become integrated parameters of the geostatistical model and are estimated alongside the other model parameters. The harmonization methods developed within the INTAMAP project were first applied within the field of radiation, where the European Radiological Data Exchange Platform (EURDEP) - http://eurdep.jrc.ec.europa.eu/ - has been active for all member states for more than a decade (de Cort and de Vries, 1997). This database contains biases because of the different networks processes used in data reporting (Bossew et al., 2007). In a comparison study, monthly averaged Gamma dose measurements from eight European countries were using the methods described above. Baume et al. (2008) showed that both methods yield similar results and can detect and remove bias from the EURDEP database. To broaden the potential of the methods developed within the INTAMAP project, another application example taken from soil science is presented in this paper. The Carbon/Nitrogen (C/N) ratio of forest soils is one of the best predictors for evaluating soil functions such as used in climate change issues. Although soil samples were analyzed according to a common European laboratory method, Carré et al. (2008) concluded that systematic errors are introduced in the measurements due to calibration issues and instability of the sample. The application of the harmonization procedures showed that bias could be adequately removed, although the procedures have difficulty to distinguish real differences from bias.

Mobile-centric ambient intelligence in health- and homecare-anticipating ethical and legal challenges.

PubMed

Kosta, Eleni; Pitkänen, Olli; Niemelä, Marketta; Kaasinen, Eija

2010-06-01

Ambient Intelligence provides the potential for vast and varied applications, bringing with it both promise and peril. The development of Ambient Intelligence applications poses a number of ethical and legal concerns. Mobile devices are increasingly evolving into tools to orientate in and interact with the environment, thus introducing a user-centric approach to Ambient Intelligence. The MINAmI (Micro-Nano integrated platform for transverse Ambient Intelligence applications) FP6 research project aims at creating core technologies for mobile device based Ambient Intelligence services. In this paper we assess five scenarios that demonstrate forthcoming MINAmI-based applications focusing on healthcare, assistive technology, homecare, and everyday life in general. A legal and ethical analysis of the scenarios is conducted, which reveals various conflicting interests. The paper concludes with some thoughts on drafting ethical guidelines for Ambient Intelligence applications.

Urban impact on air quality in RegCM/CAMx couple for MEGAPOLI project - high resolution sensitivity study

NASA Astrophysics Data System (ADS)

Halenka, T.; Huszar, P.; Belda, M.

2010-09-01

Recent studies show considerable effect of atmospheric chemistry and aerosols on climate on regional and local scale. For the purpose of qualifying and quantifying the magnitude of climate forcing due to atmospheric chemistry/aerosols on regional scale, the development of coupling of regional climate model and chemistry/aerosol model was started on the Department of Meteorology and Environmental Protection, Charles University, Prague, for the EC FP6 Project QUANTIFY and EC FP6 Project CECILIA. For this coupling, existing regional climate model and chemistry transport model have been used at very high resolution of 10km grid. Climate is calculated using RegCM while chemistry is solved by CAMx. The experiments with the couple have been prepared for EC FP7 project MEGAPOLI assessing the impact of the megacities and industrialized areas on climate. Meteorological fields generated by RCM drive CAMx transport, chemistry and a dry/wet deposition. A preprocessor utility was developed for transforming RegCM provided fields to CAMx input fields and format. New domain have been settled for MEGAPOLI purpose in 10km resolution including all the European "megacities" regions, i.e. London metropolitan area, Paris region, industrialized Ruhr area, Po valley etc. There is critical issue of the emission inventories available for 10km resolution including the urban hot-spots, TNO emissions are adopted for this sensitivity study in 10km resolution for comparison of the results with the simulation based on merged TNO emissions, i.e. basically original EMEP emissions at 50 km grid. The sensitivity test to switch on/off Paris area emissions is analysed as well. Preliminary results for year 2005 are presented and discussed to reveal whether the concept of effective emission indices could help to parameterize the urban plume effects in lower resolution models. Interactive coupling is compared to study the potential of possible impact of urban air-pollution to the urban area climate.

Galaxy Properties Across and Through the 6dFGS Fundamental Plane

NASA Astrophysics Data System (ADS)

Springob, Chris M.; Magoulas, C.; Proctor, R.; Colless, M.; Jones, D. H.; Kobayashi, C.; Campbell, L.; Lucey, J.; Mould, J.; Merson, A.

2011-05-01

The 6dF Galaxy Survey (6dFGS) is an all southern sky galaxy survey, including 125,000 redshifts and a Fundamental Plane (FP) subsample of 10,000 peculiar velocities, making it the largest peculiar velocity sample to date. We have developed a robust procedure for fitting the FP, performing a maximum likelihood fit to a tri-variate Gaussian. We have subsequently examined the variation of a variety of properties across and through the FP, including environment, morphology, metallicity, alpha-enhancement, and stellar age. We find little variation in the FP with global environment. Some variation of morphology is found along the plane, though this is likely a consequence of selection effects. Elemental abundances are found to vary both across and through the FP. The parameter that varies most directly through the FP is stellar age. We find that galaxies with stellar populations with average ages older than 3 Gyr occupy a thinner FP than those younger than 3 Gyr. Thus, a modest improvement in distance errors is realized if one divides the sample into subsamples segregated by age, and fits the FP of each subsample independently.

Fertility desires and unmet need for family planning among HIV infected individuals in two HIV clinics with differing models of family planning service delivery.

PubMed

Wanyenze, Rhoda K; Matovu, Joseph K B; Kamya, Moses R; Tumwesigye, Nazarius M; Nannyonga, Maria; Wagner, Glenn J

2015-01-28

Eliminating family planning (FP) unmet need among HIV-infected individuals (PLHIV) is critical to elimination of mother-to-child HIV transmission. We assessed FP unmet need among PLHIV attending two clinics with differing models of FP services. Nsambya Home Care provided only FP information while Mulago HIV clinic provided information and contraceptives onsite. In a cross-sectional study conducted between February-June 2011, we documented pregnancies, fertility desires, and contraceptive use among 797 HIV-infected men and women (408 in Mulago and 389 in Nsambya). FP unmet need was calculated among women who were married, unmarried but had sex within the past month, did not desire the last or future pregnancy at all or wished to postpone for ≥ two years and were not using contraceptives. Multivariable analyses for correlates of FP unmet need were computed for each clinic. Overall, 40% (315) had been pregnant since HIV diagnosis; 58% desired the pregnancies. Of those who were not pregnant, 49% (366) did not desire more children at all; 15.7% wanted children then and 35.3% later. The unmet need for FP in Nsambya (45.1%) was significantly higher than that in Mulago at 30.9% (p = 0.008). Age 40+ compared to 18-29 years (OR = 6.05; 95% CI: 1.69, 21.62 in Mulago and OR = 0.21; 95% CI: 0.05, 0.90 in Nsambya), other Christian denominations (Pentecostal and Seventh Day Adventists) compared to Catholics (OR = 7.18; 95% CI: 2.14, 24.13 in Mulago and OR = 0.23; 95% CI: 0.06, 0.80 in Nsambya), and monthly expenditure > USD 200 compared to < USD40 in Nsambya (OR = 0.17; 95% CI: 0.03, 0.90) were associated with FP unmet need. More than half of the pregnancies in this population were desired. Unmet need for FP was very high at both clinics and especially at the clinic which did not have contraceptives onsite. Lower income and younger women were most affected by the lack of contraceptives onsite. Comprehensive and aggressive FP programs are required for fertility support and elimination of FP unmet need among PLHIV, even with integration of FP information and supplies into HIV clinics.

Guatemala -- strength is NGO cooperation.

PubMed

1999-04-01

In early 1999, representations of the UN Population Fund, JOICFP, and APROFAM met in Guatemala to monitor progress of an integrated program promoting reproductive health (RH) and family planning (FP) among Mayans in the Department of Solola. The team observed field activities, such as training, and assessed information, education, and communication (IEC) promotion; service delivery; institutional coordination; and adolescent health programs. The program is training traditional birth attendants (TBAs) to provide RH/FP and general medical services. At one site, a TBA acquires counseling for her clients from a physician via the telephone. This activity will be facilitated with the addition of radio receivers. Resources have been maximized by increasing collaboration among the project, the government, and local nongovernmental organizations. Referrals are being facilitated with improved communication tools and provision of a boat and ambulance for transporting clients. Cooperative efforts are also being made to promote community health and development, health education, and adolescent health.

Monitoring Soil Infiltration In Semi-Arid Regions With Meteosat And A Coupled Model Approach Using PROMET And SLC

NASA Astrophysics Data System (ADS)

Klug, P.; Bach, H.; Migdall, S.

2013-12-01

In arid regions the infiltration of sparse rainfalls and resulting ground water recharge is a critical quantity for the water cycle. With the PROMET model the infiltration process can be simulated in detail, since 4 soil layers together with the hourly calculation time step allow simulating the vertical water transport. Wet soils are darker than dry soils. Using the SLC reflectance model this effect can be simulated and compared to temporal high resolution time series of measured reflectances from Meteosat in order to monitor the drying process. This study demonstrates how MSG can be used to better parameterize the simulation of the infiltration process and reduce uncertainties in ground water recharge estimation. The study is carried out in the frame of the EU FP7 project CLIMB (Climate Induced Changes on the Hydrology of Mediterranean Basins). According to climate projections, Mediterranean countries are at risk of changes in the hydrological budget, the agricultural productivity and drinking water supply in the future. The CLIMB FP-7 project coordinated by the University of Munich (LMU) aims at employing integrated hydrological modelling in a new framework to reduce existing uncertainties in climate change impact analysis of the Mediterranean region [1, 2].

KP-LAB: Breaking New Ground on How to Create Knowledge through Learning

ERIC Educational Resources Information Center

Reynolds, Sally; Camilleri, Anthony Fisher

2010-01-01

The 5 year KP-Lab project funded under the FP6 of the European Commission's Programme for Research and Technological Development is about developing theories, tools, practical models, and research methods that deliberately advance the ways in which knowledge is created and which help to transform knowledge practices in education and in the…

Use of HIV counseling and testing and family planning services among postpartum women in Kenya: a multicentre, non-randomised trial.

PubMed

Kimani, James; Warren, Charlotte E; Abuya, Timothy; Ndwiga, Charity; Mayhew, Susannah; Vassall, Anna; Mutemwa, Richard; Askew, Ian

2015-11-13

Addressing the postnatal needs of new mothers is a neglected area of care throughout sub-Saharan Africa. The study compares the effectiveness of integrating HIV and family planning (FP) services into postnatal care (PNC) with stand-alone services on postpartum women's use of HIV counseling and testing and FP services in public health facilities in Kenya. Data were derived from samples of women who had been assigned to intervention or comparison groups, had given birth within the previous 0-10 weeks and were receiving postnatal care, at baseline and 15 months later. Descriptive statistics describe the characteristics of the sample and multivariate logistic regression models assess the effect of the integrated model of care on use of provider-initiated testing and counseling (PITC) and FP services. At the 15-month follow-up interviews, more women in the intervention than comparison sites used implants (15 % vs. 3 %; p < 0.001), while injectables were the most used short-term method by women in both sites. Women who wanted to wait until later to have children (OR = 1.3; p < 0.01; 95 % CI: 1.1-1.5), women with secondary education (OR = 1.2; p < 0.05; 95 % CI: 1.0-1.4), women aged 25-34 years (OR = 1.2; p < 0.01; 95 % CI: 1.1-1.4) and women from poor households (OR = 1.6; p < 0.001; 95 % CI: 1.4-1.9) were associated with FP use. Nearly half (47 %) and about one-third (30 %) of mothers in the intervention and comparison sites, respectively, were offered PITC. Significant predictors of uptake of PITC were seeking care in a health center/dispensary relative to a hospital, having a partner who has tested for HIV and being poor. An integrated delivery approach of postnatal services is beneficial in increasing the uptake of PITC and long-acting FP services among postpartum women. Also, interventions aimed at increasing male partners HIV testing have a positive effect on the uptake of PITC and should be encouraged. ClinicalTrials.gov NCT01694862.

ACTRIS aerosol vertical profile data and observations: potentiality and first examples of integrated studies with models

NASA Astrophysics Data System (ADS)

Mona, Lucia; Benedetti, Angela; D'Amico, Giuseppe; Myhre, Cathrine Lund; Schulz, Michael; Wandinger, Ulla; Laj, Paolo; Pappalardo, Gelsomina

2016-04-01

The ACTRIS-2 project, funded by Horizon 2020, addresses the scope of integrating state-of-the-art European ground-based stations for long term observations of aerosols, clouds and short lived gases, capitalizing on the work of FP7-ACTRIS. It aims at achieving the construction of a user-oriented RI, unique in the EU-RI landscape for providing 4-D integrated high-quality data from near-surface to high altitude (vertical profiles and total-column) which are relevant to climate and air-quality research. ACTRIS-2 develops and implements, in a large network of stations in Europe and beyond, observational protocols that permit the harmonization of collected data and their dissemination. ACTRIS secures provision and dissemination of a unique set of data and data-products that would not otherwise be available with the same level of quality and standardization. This results from a 10-year plus effort in constructing a research infrastructure capable of responding to community needs and requirements, and has been engaged since the start of the FP5 EU commission program. ACTRIS ensures compliance with reporting requirements (timing, format, traceability) defined by the major global observing networks. EARLINET (European Aerosol research Lidar NETwork), the aerosol vertical profiling component of ACTRIS, is providing since May 2000 vertical profiles of aerosol extinction and backscatter over Europe. A new structure of the EARLINET database has been designed in a more user oriented approach reporting new data products which are more effective for specific uses of different communities. In particular, a new era is starting with the Copernicus program during which the aerosol vertical profiling capability will be fundamental for assimilation and validation purposes. The new data products have been designed thanks to a strong link with EARLINET data users, first of all modeling and satellite communities, established since the beginning of EARLINET and re-enforced within ACTRIS2. The potentiality of the new EARLINET data products and first examples of integrated studies with models will be presented at the conference. Acknowledgments: ACTRIS2 Research Infrastructure Project is funded by the European Union's Horizon 2020 research and innovation programme under the grant agreement n. 654169 and previously under FP7 grant agreement n. 262254.

Tunable electromagnetically induced transparency in integrated silicon photonics circuit.

PubMed

Li, Ang; Bogaerts, Wim

2017-12-11

We comprehensively simulate and experimentally demonstrate a novel approach to generate tunable electromagnetically induced transparency (EIT) in a fully integrated silicon photonics circuit. It can also generate tunable fast and slow light. The circuit is a single ring resonator with two integrated tunable reflectors inside, which form an embedded Fabry-Perot (FP) cavity inside the ring cavity. The mode of the FP cavity can be controlled by tuning the reflections using integrated thermo-optic tuners. Under correct tuning conditions, the interaction of the FP mode and the ring resonance mode will generate a Fano resonance and an EIT response. The extinction ratio and bandwidth of the EIT can be tuned by controlling the reflectors. Measured group delay proves that both fast light and slow light can be generated under different tuning conditions. A maximum group delay of 1100 ps is observed because of EIT. Pulse advance around 1200 ps is also demonstrated.

The association rules search of Indonesian university graduate’s data using FP-growth algorithm

NASA Astrophysics Data System (ADS)

Faza, S.; Rahmat, R. F.; Nababan, E. B.; Arisandi, D.; Effendi, S.

2018-02-01

The attribute varieties in university graduates data have caused frustrations to the institution in finding the combinations of attributes that often emerge and have high integration between attributes. Association rules mining is a data mining technique to determine the integration of the data or the way of a data set affects another set of data. By way of explanation, there are possibilities in finding the integration of data on a large scale. Frequent Pattern-Growth (FP-Growth) algorithm is one of the association rules mining technique to determine a frequent itemset in an FP-Tree data set. From the research on the search of university graduate’s association rules, it can be concluded that the most common attributes that have high integration between them are in the combination of State-owned High School outside Medan, regular university entrance exam, GPA of 3.00 to 3.49 and over 4-year-long study duration.

Robotic and artificial intelligence for keyhole neurosurgery: the ROBOCAST project, a multi-modal autonomous path planner.

PubMed

De Momi, E; Ferrigno, G

2010-01-01

The robot and sensors integration for computer-assisted surgery and therapy (ROBOCAST) project (FP7-ICT-2007-215190) is co-funded by the European Union within the Seventh Framework Programme in the field of information and communication technologies. The ROBOCAST project focuses on robot- and artificial-intelligence-assisted keyhole neurosurgery (tumour biopsy and local drug delivery along straight or turning paths). The goal of this project is to assist surgeons with a robotic system controlled by an intelligent high-level controller (HLC) able to gather and integrate information from the surgeon, from diagnostic images, and from an array of on-field sensors. The HLC integrates pre-operative and intra-operative diagnostics data and measurements, intelligence augmentation, multiple-robot dexterity, and multiple sensory inputs in a closed-loop cooperating scheme including a smart interface for improved haptic immersion and integration. This paper, after the overall architecture description, focuses on the intelligent trajectory planner based on risk estimation and human criticism. The current status of development is reported, and first tests on the planner are shown by using a real image stack and risk descriptor phantom. The advantages of using a fuzzy risk description are given by the possibility of upgrading the knowledge on-field without the intervention of a knowledge engineer.

Oncofertility resources at NCI-designated comprehensive cancer centers.

PubMed

Clayman, Marla L; Harper, Maya M; Quinn, Gwendolyn P; Reinecke, Joyce; Shah, Shivani

2013-12-01

NCI-designated comprehensive cancer centers (CCCs) set the standard for providing exemplary patient care. Quality cancer care includes discussions about fertility and referrals to fertility specialists for patients at risk for sterility. This study sought to determine what fertility preservation (FP) resources are available in CCCs and how well those are integrated into patient care. Leaders at each CCC received a letter requesting a short telephone interview with individuals who could provide information about the institution's FP resources. A semi-structured interview guide was used and responses were audio-recorded. Data were analyzed using content and thematic analysis. Interviews were conducted with 30 of the 39 CCCs that see adult patients (77%). The remaining institutions included 4 nonresponders, 3 that referred the interviewers to childhood cancer survivorship clinics, 1 that refused, and 1 that could not identify any FP resources. Participants were primarily affiliated with reproductive endocrinology (n=15) or hematology/oncology divisions (n=10). Institutional policies regarding consistent provision of FP information were rare (n=4), although most sites (n=20) either had some services on-site or had referral programs (n=8). However, only 13 had some experimental services, such as ovarian tissue cryopreservation. Respondents reported barriers to provision of FP, including oncologists' identification of patients at risk, low referral rates, and perceptions of patient prognosis. Only 8 (27%) sites had staff with time dedicated to FP. CCCs vary widely in implementing FP-recommended practice to their patients. CCCs are positioned to provide exemplary oncofertility care, but most need to better integrate FP information and referral into practice.

FP-180 Water Motor AFFF Proportioner First Article Procedure and Evaluation

DTIC Science & Technology

1989-07-20

concentrates. The first fluorocarbon-based Aqueous Film Forming Foam ( AFFF ) concentrate fully suitable for use with ocean water was FC -195, which had a...Fil E W Y. . Naval Research Laboratory Washington, DC 20375-500 NRL Memorandum Report 6507 FP-180 Water Motor AFFF Proportioner First Article...NUMBERS PROGRAM :PROJECT TASK WORK UNIT ELEMENT NO NO NO ACCESSION NO 11 TITLE (Include Security Classification) FP-180 Water Motor AFFF Proportioner

An innovative simplified MCH score for assessing the ideal babies in well baby shows of postpartum outreach programme.

PubMed

Anandalakshmy, P N; Mittal, S

1995-01-01

In India, a simple scoring method was used to select winners at 18 well-baby shows over the last five years in low-income areas of Kotla Mubarakpur and Gautam Nagar, in the Rajeev Gandhi Resettlement Colony, in jhuggi jhopri clusters around the All Institute of Medical Sciences (AAIMS) in New Delhi, and in the Bangladeshi refugee colony (Kidwai Nagar). The parameters used to select ideal babies were parents' age at marriage and educational status, mother's age at first birth, number of living children in relation to marriage duration, immunization status of living children, birth interval, contraceptive use, and routine criteria on general health and hygiene. Winners were chosen among infants, toddlers (1-2 years), and preschool children (2-5). Health promotional activities, maternal and child health (MCH) services, and family planning (FP) services were featured at the health camps where the well-baby shows occurred. 60-90 children and 100-2000 couples participated in the well-baby shows. Health workers explained to parents of children with a poor score why their children had a poor score. At the health camps, parents adopted FP methods and had their children immunized, regardless of score, so as to improve their score for the next show and to win prizes. The well-baby scores improved over time (24.64-31.2 for Kotla Mubarakpur, 19-24.6 for Gautam Nagar, 20.9-22.4 for Rajeev Gandhi, 20.6-23.6 for AIIMS jhuggi, and 13.6-21.4 for Kidwai Nagar). A weekly clinic operating in Kotla Mubarakpur accounted for the high initial mean score. Gautam Nagar had only periodic health services. A weekly mobile health van provided services in the Rajeev Gandhi colony. Door to door contacts were conducted in the jhuggi jhopri clusters to promote MCH/FP services. The scoring method reinforced integration of MCH/FP services. It allowed local health workers to make rapid analyses and MCH decision making. It also served as a tool to monitor the efficacy of local MCH/FP services.

Toward a Model-Based Approach for Flight System Fault Protection

NASA Technical Reports Server (NTRS)

Day, John; Meakin, Peter; Murray, Alex

2012-01-01

Use SysML/UML to describe the physical structure of the system This part of the model would be shared with other teams - FS Systems Engineering, Planning & Execution, V&V, Operations, etc., in an integrated model-based engineering environment Use the UML Profile mechanism, defining Stereotypes to precisely express the concepts of the FP domain This extends the UML/SysML languages to contain our FP concepts Use UML/SysML, along with our profile, to capture FP concepts and relationships in the model Generate typical FP engineering products (the FMECA, Fault Tree, MRD, V&V Matrices)

Sustainability and integration of radioecology-position paper.

PubMed

Muikku, M; Beresford, N A; Garnier-Laplace, J; Real, A; Sirkka, L; Thorne, M; Vandenhove, H; Willrodt, C

2018-03-01

This position paper gives an overview of how the COMET project (COordination and iMplementation of a pan-European instrumenT for radioecology, a combined Collaborative Project and Coordination and Support Action under the EC/Euratom 7th Framework Programme) contributed to the integration and sustainability of radioecology in Europe via its support to and interaction with the European Radioecology ALLIANCE. COMET built upon the foundations laid by the FP7 project STAR (Strategic Network for Integrating Radioecology) Network of Excellence in radioecology. In close association with the ALLIANCE, and based on the Strategic Research Agenda (SRA), COMET developed innovative mechanisms for joint programming and implementation of radioecological research. To facilitate and foster future integration under a common federating structure, research activities developed within COMET were targeted at radioecological research needs identified in the SRA. Furthermore, COMET maintained and developed strong mechanisms for knowledge exchange, dissemination and training to enhance and maintain European capacity, competence and skills in radioecology. In the short term the work to promote radioecology will continue under the H2020 project EJP-CONCERT (European Joint Programme for the Integration of Radiation Protection Research). The EJP-CONCERT project (2015-2020) aims to develop a sustainable structure for promoting and administering joint programming and open research calls in the field of radiation protection research for Europe. In the longer term, radioecological research will be facilitated by the ALLIANCE. External funding is, however, required in order to be able to answer emerging research needs.

Effect of postpartum suppression of ovulation on uterine involution in dairy cows.

PubMed

Heppelmann, M; Brömmling, A; Weinert, M; Piechotta, M; Wrenzycki, C; Bollwein, H

2013-09-15

The objective of this study was to investigate the effect of time of first postpartum ovulation after calving on uterine involution in dairy cows with and without uterine puerperal disease. Transvaginal follicular puncture (FP) of follicles >6 mm suppressed ovulation and development of a CL until Day 42 after calving. Fifty-three lactating Holstein Friesian cows (3.4 ± 1.2 years old, parity 2.5 ± 1.0 [median ± mean absolute deviation]) were divided into groups on the basis of the presence (UD+) or absence (UD-) of uterine disease and whether FP was carried out (FP+) or not (FP-). Uterine disease was defined as the occurrence of retained fetal membranes and/or metritis. This resulted in the following groups: UD-FP- (n = 15), UD-FP+ (n = 13), UD+FP- (n = 13), and UD+FP+ (n = 12). A general examination, vaginoscopy, transrectal palpation, and transrectal B-mode sonography of the reproductive organs were conducted on Days 8, 11, 18, and 25 and then every 10 days until Day 65 after calving. After hormonal synchronization of ovulation (cloprostenol between Days 55 and 60 postpartum and GnRH 2 days later), cows were inseminated in the next spontaneous estrus. On average, the cows ovulated on Day 21.0 ± 6.0 (UD-FP-), 50.0 ± 4.0 (UD-FP+), 16.0 ± 3.0 (UD+FP-), and 48.0 ± 2.0 (UD+FP+) postpartum. Calving-to-conception interval and first-service conception rates were not affected by FP (P > 0.05). Healthy cows with FP had smaller (P < 0.05) uterine horn and cervical diameters assessed sonographically than cows without FP. FP reduced the prevalence of purulent vaginal discharge and uterine size assessed transrectally in UD+ cows (P < 0.05). The results showed that suppression of an early ovulation by transvaginal FP improved uterine involution in cows with and without uterine disease. Copyright © 2013 Elsevier Inc. All rights reserved.

Family planning in Guinea: a need for better public commitment.

PubMed

Delamou, Alexandre; Koivogui, Akoi; Dubourg, Dominique; Delvaux, Thérèse

2014-01-01

To describe the evolution of family planning (FP) in Guinea and to identify strengths, weaknesses, opportunities and threats of the current FP programme. Descriptive study of the evolution of FP in Guinea between 1992 and 2010. First, national laws as well as health policies and strategic plans related to reproductive health and family planning were reviewed. Second, FP indicators were extracted from the Guinean Demographic and Health Surveys (1992, 1999 and 2005). Third, FP services, sources of supply and data on FP funding were analysed. Laws, policies and strategic plans in Guinea are supportive of FP programme and services. Public and private actors are not sufficiently coordinated. The general government expenditure on health has remained stable at 6-7% between 2005 and 2011 despite a doubling of total expenditures on health, and contraceptives are supplied by foreign aid. Modern contraceptive prevalence slightly increased from 1.5% in 1992 to 6.8% in 2005 among women aged 15-49. A stronger national engagement in favour of repositioning FP should result in improved government funding of the FP programme and the promotion of long-acting and permanent methods. © 2013 John Wiley & Sons Ltd.

Flexible workflow sharing and execution services for e-scientists

NASA Astrophysics Data System (ADS)

Kacsuk, Péter; Terstyanszky, Gábor; Kiss, Tamas; Sipos, Gergely

2013-04-01

The sequence of computational and data manipulation steps required to perform a specific scientific analysis is called a workflow. Workflows that orchestrate data and/or compute intensive applications on Distributed Computing Infrastructures (DCIs) recently became standard tools in e-science. At the same time the broad and fragmented landscape of workflows and DCIs slows down the uptake of workflow-based work. The development, sharing, integration and execution of workflows is still a challenge for many scientists. The FP7 "Sharing Interoperable Workflow for Large-Scale Scientific Simulation on Available DCIs" (SHIWA) project significantly improved the situation, with a simulation platform that connects different workflow systems, different workflow languages, different DCIs and workflows into a single, interoperable unit. The SHIWA Simulation Platform is a service package, already used by various scientific communities, and used as a tool by the recently started ER-flow FP7 project to expand the use of workflows among European scientists. The presentation will introduce the SHIWA Simulation Platform and the services that ER-flow provides based on the platform to space and earth science researchers. The SHIWA Simulation Platform includes: 1. SHIWA Repository: A database where workflows and meta-data about workflows can be stored. The database is a central repository to discover and share workflows within and among communities . 2. SHIWA Portal: A web portal that is integrated with the SHIWA Repository and includes a workflow executor engine that can orchestrate various types of workflows on various grid and cloud platforms. 3. SHIWA Desktop: A desktop environment that provides similar access capabilities than the SHIWA Portal, however it runs on the users' desktops/laptops instead of a portal server. 4. Workflow engines: the ASKALON, Galaxy, GWES, Kepler, LONI Pipeline, MOTEUR, Pegasus, P-GRADE, ProActive, Triana, Taverna and WS-PGRADE workflow engines are already integrated with the execution engine of the SHIWA Portal. Other engines can be added when required. Through the SHIWA Portal one can define and run simulations on the SHIWA Virtual Organisation, an e-infrastructure that gathers computing and data resources from various DCIs, including the European Grid Infrastructure. The Portal via third party workflow engines provides support for the most widely used academic workflow engines and it can be extended with other engines on demand. Such extensions translate between workflow languages and facilitate the nesting of workflows into larger workflows even when those are written in different languages and require different interpreters for execution. Through the workflow repository and the portal lonely scientists and scientific collaborations can share and offer workflows for reuse and execution. Given the integrated nature of the SHIWA Simulation Platform the shared workflows can be executed online, without installing any special client environment and downloading workflows. The FP7 "Building a European Research Community through Interoperable Workflows and Data" (ER-flow) project disseminates the achievements of the SHIWA project and use these achievements to build workflow user communities across Europe. ER-flow provides application supports to research communities within and beyond the project consortium to develop, share and run workflows with the SHIWA Simulation Platform.

Human herpesvirus-6 and -7 DNA in cerebrospinal fluid of facial palsy patients.

PubMed

Kanerva, Mervi; Jääskeläinen, Anne J; Suvela, Minna; Piiparinen, Heli; Vaheri, Antti; Pitkäranta, Anne

2008-04-01

Finding human herpesvirus (HHV)-7 and dual HHV-6A and -6B DNA in cerebrospinal fluid (CSF) of two facial palsy (FP) patients is intriguing but does not allow etiologic conclusions as such. HHV-6 or -7 DNA was revealed in 10% of the CSF samples tested from 70 immunocompetent adolescents and adults; a highly unusual result. How these findings are associated with the diseases they accompany remains to be defined. To determine whether herpes simplex virus (HSV)-1 and -2, varicella-zoster virus (VZV), HHV-6A, -6B, and -7, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) DNA could be found in CSF of FP patients or controls. In all, 33 peripheral FP patients (26 idiopathic, 5 with herpesvirus infection, 1 puerperal, 1 Melkersson-Rosenthal syndrome) (34 CSF samples) and 36 controls (16 nonidiopathic FP, 7 hearing loss, 6 vertigo, 5 headache, 2 other) previously tested for HSV-1, VZV, and HHV-6 DNA by polymerase chain reaction (PCR) were tested with highly sensitive multiplex-PCR and an oligonucleotide microarray method. One FP patient had HHV-7 DNA and another had HHV-6A and -6B DNA simultaneously. In the control group, one HHV-7, one HHV-6A, and three HHV-6B DNA-positive specimens were found.

Fingerprints and cardiovascular risk. The San Valentino fingerprint vascular screening project (SanVal/FP).

PubMed

Belcaro, G; Cesarone, M R; Ledda, A; Cornelli, U; Dugall, M; Di Renzo, A; Hosoi, M; Stuard, S; Vinciguerra, G; Pellegrini, L; Gizzi, G

2008-10-01

Fingerprints (FP), characteristic of humans, are impressions due to skin marks (ridges) on fingertips. Ridges are present on fingers/hands forming curved lines of different sizes/patterns. The point where a line stops or splits is defined typica' (their number/amount constitute identification patterns). FP are permanent and unique. This study compared FP patterns with cardiovascular risk factors: 7 main types of FP were used: 1. Arch: lines form waves from one site to the other side. 2. Tentarch: like arches but with a rising stick in the middle. 3. Loop: lines coming from one site returning in the middle to the same site. 4. Double loop: like loops but with two loops inside: one standing, one hanging. 5. Pocked loop: like the loop but with a small circle in the turning point. 6. Whorl: lines make circles. 7. Mixed figure: composed of different figures. There are two kinds of real typica: A. Ending line; B. Splitting lines (bifurcations). Several combinations may result. Ultrasound evaluation of carotid/femoral arteries in asymptomatic subjects. Arteries were evaluated with high-resolution ultrasound at the bifurcations. Four classes were defined: 1: normal intima-media (IMT) complex; 2: IMT thickening; 3: non-stenosing plaques (<50% stenosis); 4: stenosing plaque (>50%). Subjects in classes 1, 2, 3 were included into the analysis made comparing FP patterns and ultrasound. For each FP pattern: A. the main proportion of subjects with cardiovacular risk factors (91%) had arches (41.2%) and loops (either single, 38.2% or double 11.7% for a total of 49.9%). B. The remaining classes were statistically less important. C. The number of ridges per square mm was comparable in all pattern classes. D. The analysis of typica and other ridges characteristics requires a more elaborated system. Future research must define simple, low cost screening methods for preselection of subjects at higher cardiovascular risk or for exclusion of low risk subjects. The evaluation of fingerprint pattern may be useful to define risk groups.

'False-positive' self-reported psychotic experiences in the general population: an investigation of outcome, predictive factors and clinical relevance.

PubMed

van der Steen, Y; Myin-Germeys, I; van Nierop, M; Ten Have, M; de Graaf, R; van Dorsselaer, S; van Os, J; van Winkel, R

2018-04-16

Self-reported psychotic experiences (SRPE) by individuals from the general population are often unconfirmed by clinical interview and referred to as 'false-positive' (FP) SRPE. FP SRPE have been suggested to represent the mildest form of risk along the extended psychosis continuum. However, little is known about their (clinical) outcome and evolution over time. Aims of this study were to prospectively examine, in individuals with FP SRPE, (1) the prevalence of remission, persistence and transition to validated PE at 3-year follow-up; (2) potential baseline psychopathological and psychosocial predictors of persistence of FP SRPE and transition to validated PE; and (3) whether those with persistent FP SRPE and validated PE already differed on psychopathology and psychosocial factors at baseline. We tested the hypotheses that (i) individuals with FP SRPE would be more likely to have SRPE and validated PE at follow-up; and (ii) that FP SRPE would be predictive of lower functioning and more psychopathology and help-seeking behaviour at follow-up. Baseline (n = 6646) and 3-year follow-up (n = 5303) data of the second the Netherlands Mental Health Survey and Incidence Study (NEMESIS-2), a general population research project on prevalence, incidence, course and consequences of psychiatric disorders was used. Self-report of PE was followed by clinical interview to determine clinical validity. The presence of mood, anxiety and substance use disorders, childhood adversity, help-seeking and functioning as well as PE characteristics (number, frequency, distress and impact) were used in the analyses which included only individuals with complete data for both assessments waves (n = 4683). At baseline, 454 participants had any FP SRPE; of these 372 participants had complete follow-up data available. Those with baseline FP SRPE were significantly more likely to report SRPE (OR = 3.58; 95% CI 2.38-5.40, p < 0.001) and validated PE (OR = 6.26; 95% CI 3.91-10.02, p < 0.001) at follow-up. Baseline FP SRPE also predicted the presence of mood and anxiety disorders, reduced functioning and help-seeking at follow-up. Several baseline psychopathological, psychosocial and PE characteristics were predictive for the persistence of SRPE. These factors also differentiated groups with FP SRPE or validated PE from those with remitted FP SRPE at follow-up.Conclusions.'FP SRPE' are not truly 'false' as they index risk for the development of clinically relevant psychotic symptoms, development of mood and anxiety disorders and reduced functioning. Self-reported PE, even unconfirmed, warrant 'watchful waiting' and follow-up over time, especially when they are reported by individuals with reduced psychosocial functioning and general psychiatric problems.

Space weather in the EU's FP7 Space Theme. Preface to the special issue on "EU-FP7 funded space weather projects"

NASA Astrophysics Data System (ADS)

Chiarini, Paola

2013-11-01

Technological infrastructures in space and on ground provide services on which modern society and economies rely. Space weather related research is funded under the 7th Framework Programme for Research and Innovation (FP7) of the European Union in response to the need of protecting such critical infrastructures from the damage which could be caused by extreme space weather events. The calls for proposals published under the topic "Security of space assets from space weather events" of the FP7 Space Theme aimed to improve forecasts and predictions of disruptive space weather events as well as identify best practices to limit the impacts on space- and ground-based infrastructures and their data provision. Space weather related work was also funded under the topic "Exploitation of space science and exploration data", which aims to add value to space missions and Earth-based observations by contributing to the effective scientific exploitation of collected data. Since 2007 a total of 20 collaborative projects have been funded, covering a variety of physical phenomena associated with space weather, from ionospheric disturbances and scintillation, to geomagnetically induced currents at Earth's surface, to coronal mass ejections and solar energetic particles. This article provides an overview of the funded projects, touching upon some results and referring to specific websites for a more exhaustive description of the projects' outcomes.

Integration of family planning with maternal health services: an opportunity to increase postpartum modern contraceptive use in urban Uttar Pradesh, India.

PubMed

Achyut, Pranita; Mishra, Anurag; Montana, Livia; Sengupta, Ranajit; Calhoun, Lisa M; Nanda, Priya

2016-04-01

Maternal health (MH) services provide an invaluable opportunity to inform and educate women about family planning (FP). It is expected that this would enable women to choose an appropriate method and initiate contraception early in the postpartum period. In this study we examined interactions with health providers for MH services, and the effect of FP information provision during these interactions on the postpartum use of modern contraceptive methods. This study used midline data collected from 990 women who had delivered a live birth between January 2010 and the date of the midline survey in 2012. These women were asked a series of questions about their last delivery, including interactions with health providers during pregnancy, delivery and the postpartum period, if they received FP information during these interactions, and their contraceptive use during the postpartum period. The study found that FP information provision as part of antenatal care in the third trimester, delivery and the postpartum period have a positive association with postpartum modern contraceptive use in urban Uttar Pradesh. However, health providers often miss these opportunities. Despite a high proportion of women coming into contact with health providers when utilising MH services, only a small proportion received FP information during these interactions. Integration of FP with MH services can increase postpartum modern contraceptive use. With the launch of the National Urban Health Mission, there now exists appropriate policy and programmatic environments for integration of FP and MH services in urban settings in India. However, this will require a concentrated effort both to enhance the capacity of health providers and encourage supportive supervision. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

An FP7 "Space" project: Aphorism "Advanced PRocedures for volcanic and Seismic Monitoring"

NASA Astrophysics Data System (ADS)

Di Iorio, A., Sr.; Stramondo, S.; Bignami, C.; Corradini, S.; Merucci, L.

2014-12-01

APHORISM project proposes the development and testing of two new methods to combine Earth Observation satellite data from different sensors, and ground data. The aim is to demonstrate that this two types of data, appropriately managed and integrated, can provide new improved GMES products useful for seismic and volcanic crisis management. The first method, APE - A Priori information for Earthquake damage mapping, concerns the generation of maps to address the detection and estimate of damage caused by a seism. The use of satellite data to investigate earthquake damages is not an innovative issue. We can find a wide literature and projects concerning such issue, but usually the approach is only based on change detection techniques and classifications algorithms. The novelty of APE relies on the exploitation of a priori information derived by InSAR time series to measure surface movements, shake maps obtained from seismological data, and vulnerability information. This a priori information is then integrated with change detection map to improve accuracy and to limit false alarms. The second method deals with volcanic crisis management. The method, MACE - Multi-platform volcanic Ash Cloud Estimation, concerns the exploitation of GEO (Geosynchronous Earth Orbit) sensor platform, LEO (Low Earth Orbit) satellite sensors and ground measures to improve the ash detection and retrieval and to characterize the volcanic ash clouds. The basic idea of MACE consists of an improvement of volcanic ash retrievals at the space-time scale by using both the LEO and GEO estimations and in-situ data. Indeed the standard ash thermal infrared retrieval is integrated with data coming from a wider spectral range from visible to microwave. The ash detection is also extended in case of cloudy atmosphere or steam plumes. APE and MACE methods have been defined in order to provide products oriented toward the next ESA Sentinels satellite missions.The project is funded under the European Union FP7 program and the Kick-Off meeting has been held at INGV premises in Rome on 18th December 2013.

Hillary Clinton visits Pathfinder projects in Brazil.

PubMed

1996-01-01

In October 1995, US First Lady Hillary Clinton visited a maternity hospital in Salvador, Brazil, in which a family planning (FP)/reproductive health program has been administered by Pathfinder International since 1981 with funding from USAID. During her tour of the facility, Clinton learned about the high degree of unmet need for FP in the region which results from a lack of sufficient resources to meet demand. Clinton, in turn, praised the state of Bahia for its emphasis on FP in low-income areas.

The Mediterranean Supersite Volcanoes (MED-SUV) Project: an overview

NASA Astrophysics Data System (ADS)

Puglisi, G.

2013-12-01

The EC FP7 MEDiterranean SUpersite Volcanoes (MED-SUV) EC-FP7 Project, which started on June 2013, aims to improve the capacity of the scientific institutions, end users and SME forming the project consortium to assess the volcanic hazards at Italian Supersites, i.e. Mt. Etna and Campi Flegrei/Vesuvius. The Project activities will focus on the optimisation and integration of ground and space monitoring systems, the breakthrough in understanding of volcanic processes, and on the increase of the effectiveness of the coordination between the scientific and end-user communities in the hazard management. The overall goal of the project is to apply the rationale of the Supersites GEO initiative to Mt. Etna and Campi Flegrei/Vesuvius, considered as cluster of Supersites. For the purpose MED-SUV will integrate long-term observations of ground-based multidisciplinary data available for these volcanoes, i.e. geophysical, geochemical, and volcanological datasets, with Earth Observation (EO) data. Merging of different parameters over a long period will provide better understanding of the volcanic processes. In particular, given the variety of styles and intensities of the volcanic activity observed at these volcanoes, and which make them sort of archetypes for 'closed conduit '; and ';open conduit' volcanic systems, the combination of different data will allow discrimination between peculiar volcano behaviours associated with pre-, syn- and post-eruptive phases. Indeed, recognition of specific volcano patterns will allow broadening of the spectrum of knowledge of geo-hazards, as well as better parameterisation and modelling of the eruptive phenomena and of the processes occurring in the volcano supply system; thus improving the capability of carrying out volcano surveillance activities. Important impacts on the European industrial sector, arising from a partnership integrating the scientific community and SMEs to implement together new observation/monitoring sensors/systems, are also expected. MED-SUV proposes the development and implementation of a state-of-the-art e-infrastructure for the data integration and sharing and for volcanic risk management life-cycle, from observation to people preparedness. Experiments and studies will be devoted to better understanding of the internal structures and related dynamics of the case study volcanoes, as well as to recognition of signals associated with to impending unrest or eruptive phases. Hazard quantitative assessment will benefit by the outcomes of these studies and by their integration into the cutting edge monitoring approaches, thus leading to a step-change in hazard awareness and preparedness, and leveraging the close relationship between scientists, SMEs, and end-users. The applicability of the project outcomes will be tested on the cluster of Supersite itself during a Pilot phase, as well as on other volcanic systems with similar behaviours like Piton de la Fournaise (Reunion Island) and Azores.

The Mediterranean Supersite Volcanoes (MED-SUV) Project: an overview

NASA Astrophysics Data System (ADS)

Puglisi, Giuseppe

2014-05-01

The EC FP7 MEDiterranean SUpersite Volcanoes (MED-SUV) EC-FP7 Project, which started on June 2013, aims to improve the capacity of the scientific institutions, end users and SME forming the project consortium to assess the volcanic hazards at Italian Supersites, i.e. Mt. Etna and Campi Flegrei/Vesuvius. The Project activities will focus on the optimisation and integration of ground and space monitoring systems, the breakthrough in understanding of volcanic processes, and on the increase of the effectiveness of the coordination between the scientific and end-user communities in the hazard management. The overall goal of the project is to apply the rationale of the Supersites GEO initiative to Mt. Etna and Campi Flegrei/Vesuvius, considered as cluster of Supersites. For the purpose MED-SUV will integrate long-term observations of ground-based multidisciplinary data available for these volcanoes, i.e. geophysical, geochemical, and volcanological datasets, with Earth Observation (EO) data. Merging of different parameters over a long period will provide better understanding of the volcanic processes. In particular, given the variety of styles and intensities of the volcanic activity observed at these volcanoes, and which make them sort of archetypes for 'closed conduit ' and 'open conduit' volcanic systems, the combination of different data will allow discrimination between peculiar volcano behaviours associated with pre-, syn- and post-eruptive phases. Indeed, recognition of specific volcano patterns will allow broadening of the spectrum of knowledge of geo-hazards, as well as better parameterisation and modelling of the eruptive phenomena and of the processes occurring in the volcano supply system; thus improving the capability of carrying out volcano surveillance activities. Important impacts on the European industrial sector, arising from a partnership integrating the scientific community and SMEs to implement together new observation/monitoring sensors/systems, are also expected. MED-SUV proposes the development and implementation of a state-of-the-art e-infrastructure for the data integration and sharing and for volcanic risk management life-cycle, from observation to people preparedness. Experiments and studies will be devoted to better understanding of the internal structures and related dynamics of the case study volcanoes, as well as to recognition of signals associated with to impending unrest or eruptive phases. Hazard quantitative assessment will benefit by the outcomes of these studies and by their integration into the cutting edge monitoring approaches, thus leading to a step-change in hazard awareness and preparedness, and leveraging the close relationship between scientists, SMEs, and end-users. The applicability of the project outcomes will be tested on the cluster of Supersite itself during a Pilot phase, as well as on other volcanic systems with similar behaviours like Piton de la Fournaise (Reunion Island) and Azores.

Ground observations and remote sensing data for integrated modelisation of water budget in the Merguellil catchment, Tunisia

NASA Astrophysics Data System (ADS)

Mougenot, Bernard

2016-04-01

The Mediterranean region is affected by water scarcity. Some countries as Tunisia reached the limit of 550 m3/year/capita due overexploitation of low water resources for irrigation, domestic uses and industry. A lot of programs aim to evaluate strategies to improve water consumption at regional level. In central Tunisia, on the Merguellil catchment, we develop integrated water resources modelisations based on social investigations, ground observations and remote sensing data. The main objective is to close the water budget at regional level and to estimate irrigation and water pumping to test scenarios with endusers. Our works benefit from French, bilateral and European projects (ANR, MISTRALS/SICMed, FP6, FP7…), GMES/GEOLAND-ESA) and also network projects as JECAM and AERONET, where the Merguellil site is a reference. This site has specific characteristics associating irrigated and rainfed crops mixing cereals, market gardening and orchards and will be proposed as a new environmental observing system connected to the OMERE, TENSIFT and OSR systems respectively in Tunisia, Morocco and France. We show here an original and large set of ground and remote sensing data mainly acquired from 2008 to present to be used for calibration/validation of water budget processes and integrated models for present and scenarios: - Ground data: meteorological stations, water budget at local scale: fluxes tower, soil fluxes, soil and surface temperature, soil moisture, drainage, flow, water level in lakes, aquifer, vegetation parameters on selected fieds/month (LAI, height, biomass, yield), land cover: 3 times/year, bare soil roughness, irrigation and pumping estimations, soil texture. - Remote sensing data: remote sensing products from multi-platform (MODIS, SPOT, LANDSAT, ASTER, PLEIADES, ASAR, COSMO-SkyMed, TerraSAR X…), multi-wavelength (solar, micro-wave and thermal) and multi-resolution (0.5 meters to 1 km). Ground observations are used (1) to calibrate soil-vegetation-atmosphere models at field scale on different compartment and irrigated and rainfed land during a limited time (seasons or set of dry and wet years), (2) to calibrate and validate particularly evapotranspiration derived from multi-wavelength satellite data at watershed level in relationships with the aquifer conditions: pumping and recharge rate. We will point out some examples.

China's women leaders promote quality and equity in family planning.

PubMed

He, S

1995-08-01

In China, key policy-makers at the highest levels of government recognize that the success of the family planning (FP) program depends upon improving the status of Chinese women. The highest ranking female government official, Peng Peiyun, a State Councilor and the Minister of the State Family Planning (FP) Commission, has initiated a new policy of improving the quality of service in the FP program. She recognizes that women who are gainfully employed and control their income are less likely to desire large families. One aspect of the effort to improve quality involves training FP personnel in interpersonal communication and counseling skills. The results of a pilot training program show that clients are pleased with the new approach and that use of FP services has increased. The FP Commission is also experimenting with programs which integrate all the needs of women and their families (FP, credit availability, old age support) in rural areas. Traditionally, sons provided for their elderly parents, so families with only one daughter are concerned about old age provision. Thus, national efforts are underway to develop social security systems. In the meantime, women at all levels, from grassroots FP acceptors to FP staff members and researchers are the major contributors to the innovations which will allow China to control its population growth.

Reality check in the project management of EU funding

NASA Astrophysics Data System (ADS)

Guo, Chenbo

2015-04-01

A talk addressing workload, focuses, impacts and outcomes of project management (hereinafter PM) Two FP7 projects serve as objects for investigation. In the Earth Science sector NACLIM is a large scale collaborative project with 18 partners from North and West Europe. NACLIM aims at investigating and quantifying the predictability of the North Atlantic/Arctic sea surface temperature, sea ice variability and change on seasonal to decadal time scales which have a crucial impact on weather and climate in Europe. PRIMO from Political Science is a global PhD program funded by Marie Curie ITN instrument with 11 partners from Europe, Eurasia and BRICS countries focusing on the rise of regional powers and its impact on international politics at large. Although the two projects are granted by different FP7 funding instruments, stem from different cultural backgrounds and have different goals, the inherent processes and the key focus of the PM are quite alike. Only the operational management is at some point distinguished from one another. From the administrative point of view, understanding of both EU requirements and the country-specific regulations is essential; it also helps us identifying the grey area in order to carry out the projects more efficiently. The talk will focus on our observation of the day-to-day PM flows - primarily the project implementation - with few particular cases: transparency issues, e.g. priority settings of non-research stakeholders including the conflict in the human resources field, End-User integration, gender issues rising up during a monitoring visit and ethical aspects in field research. Through a brief comparison of both projects we summarize a range of dos and don'ts, an "acting instead of reacting" line of action, and the conclusion to a systematic overall management instead of exclusively project controlling. In a nutshell , the talk aims at providing the audience a summary of the observation in management methodologies and toolkits applied in both projects, our best practices and lessons learnt in coordinating large international consortia.

Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities.

PubMed

Sharif, Najam A; Kaddour-Djebbar, Ismail; Abdel-Latif, Ata A

2008-04-01

The pharmacologic characteristics of a number of FP-class prostaglandin (PG) analogs were determined by using the cat iris sphincter smooth-muscle-contraction assay. Cumulative concentration-response curves were generated for each compound. The relative agonist potencies (EC(50)) of the compounds were: cloprostenol (0.0012 +/- 0.0004 nM) > travoprost acid (0.46 +/- 0.13 nM) = bimatoprost acid (0.99 +/- 0.19 nM) > (+/-)-fluprostenol (15.8 +/- 2.6 nM) = PGF(2alpha) (18.6 +/- 1.8 nM) > latanoprost acid (29.9 +/- 1.6 nM) > bimatoprost (140 +/- 45 nM) > S-1033 (588 +/- 39 nM) > unoprostone (UF-021; 1280 +/- 50 nM; n = 4-14). The maximum response induced by travoprost acid (122% +/- 2.3% maximum response relative to PGF(2alpha)) was significantly greater than that induced by all the other PG compounds (P < 0.001 - P < 0.02). Interestingly, the FP-receptor antagonist, AL-8810, behaved as a moderate efficacy partial agonist (EC(50) = 2140 +/- 190 nM; 63 +/- 4.3% maximum response relative to PGF(2alpha)), indicating that the cat iris contains an extremely well-coupled FP-receptor population, and/or the tissue contains an extremely high density of the FP-receptor and/or spare receptors. The cat iris contraction data were well correlated with other FP-receptor-mediated signal-transduction processes, including FP-receptor binding in bovine corpus luteum (r = 0.86), FP-receptor binding in human iris (r = 0.61), phosphoinositide (PI) hydrolysis in human ciliary muscle and trabecular meshwork cells (r = 0.77 - 0.86), PI turnover in rat and mouse cells (r = 0.73 - 0.76) and via cloned human FP-receptor (r = 0.9), and rat uterus contraction (r = 0.84). These data confirm the presence of functional FP-receptors in the cat iris sphincter, which are exquisitely well coupled and which respond to a variety of FP-class PG analogs with differing potencies.

Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015.

PubMed

Bousquet, J; Anto, J M; Akdis, M; Auffray, C; Keil, T; Momas, I; Postma, D S; Valenta, R; Wickman, M; Cambon-Thomsen, A; Haahtela, T; Lambrecht, B N; Lodrup Carlsen, K C; Koppelman, G H; Sunyer, J; Zuberbier, T; Annesi-Maesano, I; Arno, A; Bindslev-Jensen, C; De Carlo, G; Forastiere, F; Heinrich, J; Kowalski, M L; Maier, D; Melén, E; Palkonen, S; Smit, H A; Standl, M; Wright, J; Asarnoj, A; Benet, M; Ballardini, N; Garcia-Aymerich, J; Gehring, U; Guerra, S; Hohman, C; Kull, I; Lupinek, C; Pinart, M; Skrindo, I; Westman, M; Smagghe, D; Akdis, C; Albang, R; Anastasova, V; Anderson, N; Bachert, C; Ballereau, S; Ballester, F; Basagana, X; Bedbrook, A; Bergstrom, A; von Berg, A; Brunekreef, B; Burte, E; Carlsen, K H; Chatzi, L; Coquet, J M; Curin, M; Demoly, P; Eller, E; Fantini, M P; Gerhard, B; Hammad, H; von Hertzen, L; Hovland, V; Jacquemin, B; Just, J; Keller, T; Kerkhof, M; Kiss, R; Kogevinas, M; Koletzko, S; Lau, S; Lehmann, I; Lemonnier, N; McEachan, R; Mäkelä, M; Mestres, J; Minina, E; Mowinckel, P; Nadif, R; Nawijn, M; Oddie, S; Pellet, J; Pin, I; Porta, D; Rancière, F; Rial-Sebbag, A; Saeys, Y; Schuijs, M J; Siroux, V; Tischer, C G; Torrent, M; Varraso, R; De Vocht, J; Wenger, K; Wieser, S; Xu, C

2016-11-01

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda. © 2016 The Authors. Allergy Published by John Wiley & Sons Ltd.

Simple locking of infrared and ultraviolet diode lasers to a visible laser using a LabVIEW proportional-integral-derivative controller on a Fabry-Perot signal.

PubMed

Kwolek, J M; Wells, J E; Goodman, D S; Smith, W W

2016-05-01

Simultaneous laser locking of infrared (IR) and ultraviolet lasers to a visible stabilized reference laser is demonstrated via a Fabry-Perot (FP) cavity. LabVIEW is used to analyze the input, and an internal proportional-integral-derivative algorithm converts the FP signal to an analog locking feedback signal. The locking program stabilized both lasers to a long term stability of better than 9 MHz, with a custom-built IR laser undergoing significant improvement in frequency stabilization. The results of this study demonstrate the viability of a simple, computer-controlled, non-temperature-stabilized FP locking scheme for our applications, laser cooling of Ca(+) ions, and its use in other applications with similar modest frequency stabilization requirements.

The 6dFGS Fundamental Plane

NASA Astrophysics Data System (ADS)

Springob, Chris M.; Colless, M.; Jones, D. H.; Magoulas, C.; Mould, J. R.; Campbell, L.; Lah, P.; Lucey, J.; Merson, A.; Proctor, R.

2010-01-01

The 6dF Galaxy Survey (6dFGS) is an all southern sky galaxy survey, including 125,000 redshifts and more than 10,000 peculiar velocities, making it the largest peculiar velocity sample to date. In combination with 2MASS surface brightnesses and effective radii, 6dFGS yields the near-infrared Fundamental Plane (FP) for a large and uniform sample. We have fit the FP relation for the galaxies in the peculiar velocity sample using a maximum likelihood method which allows us to precisely account for selection effects and observational errors. We investigate the effects of varying stellar populations and environments on the FP. Finally, we discuss the implications of these results both for our understanding of the origin of the FP for early-type galaxies and bulges and for deriving unbiased distances and peculiar velocities in the local universe.

Toward a Model-Based Approach to Flight System Fault Protection

NASA Technical Reports Server (NTRS)

Day, John; Murray, Alex; Meakin, Peter

2012-01-01

Fault Protection (FP) is a distinct and separate systems engineering sub-discipline that is concerned with the off-nominal behavior of a system. Flight system fault protection is an important part of the overall flight system systems engineering effort, with its own products and processes. As with other aspects of systems engineering, the FP domain is highly amenable to expression and management in models. However, while there are standards and guidelines for performing FP related analyses, there are not standards or guidelines for formally relating the FP analyses to each other or to the system hardware and software design. As a result, the material generated for these analyses are effectively creating separate models that are only loosely-related to the system being designed. Development of approaches that enable modeling of FP concerns in the same model as the system hardware and software design enables establishment of formal relationships that has great potential for improving the efficiency, correctness, and verification of the implementation of flight system FP. This paper begins with an overview of the FP domain, and then continues with a presentation of a SysML/UML model of the FP domain and the particular analyses that it contains, by way of showing a potential model-based approach to flight system fault protection, and an exposition of the use of the FP models in FSW engineering. The analyses are small examples, inspired by current real-project examples of FP analyses.

Effects of Dehydration on Cricket Specific Skill Performance in Hot and Humid Conditions.

PubMed

Gamage, Janaka P; De Silva, Angela P; Nalliah, Arjan K; Galloway, Stuart D R

2016-12-01

The aim of the current study was to assess the effects of dehydration on cricket specific motor skill performance among fast-bowlers, fielders, and batsmen playing in a hot and humid environment. 10 fast-bowlers, 12 fielders and 8 batsmen participated in two field trials conducted 7 days apart: a fluid provision trial (FP) and a fluid restriction trial (FR). Each trial consisted of a 2-hr standardized training session and pretraining and posttraining skill performance assessments. Bowling speed and accuracy (line and length), throwing speed and accuracy (overarm, sidearm and underarm) and timed running between wickets (1, 2, and 3 runs) was assessed pre to posttraining in each trial. Mass loss was 0.6 ± 0.3 kg (0.9 ± 0.5%) in FP, and 2.6 ± 0.5kg (3.7 ± 0.8%) in FR trials. Maintaining mass within 1% of initial values did not cause any significant skill performance decline. However, the dehydration on the FR trial induced a significant time and trial effect for bowling speed by 1.0 ± 0.8% reduction (0.3 ± 0.8% reduction in FP trial; p < .01) and 19.8 ± 17.3% reduction in bowling accuracy for line (3.6 ± 14.2% reduction in FP trial; p < .01), but no effect on bowling length. A significant decline was noted in the FR trial for throwing speed for overarm (6.6 ± 4.1%; p < .01; 1.6 ± 3.4% reduction in FP trial) and sidearm (4.1 ± 2.3%; p < .01; 0.6 ± 4.7% increase in FP trial) techniques, and for throwing accuracy for overarm (14.2 ± 16.3%; p < .01; 0.8 ± 24.2% increase in FP trial) and sidearm (22.3 ± 13.3%; p < .05; 3.2 ± 34.9% reduction in FP trial) techniques. Batsmen demonstrated significant performance drop in making three runs (0.8 ± 1.2% increase in time in FP trial and 2.2 ± 1.7% increase in time in FR trial; p < .01). Moderate-severe dehydration of 3.7% body mass loss significantly impairs motor skill performance among cricketers, particularly bowlers and fielders, playing in hot and humid conditions. Fluid ingestion strategies maintaining mass loss within 1% prevented a decline in skill performance.

CFD analysis of aircraft fuel tanks thermal behaviour

NASA Astrophysics Data System (ADS)

Zilio, C.; Longo, G. A.; Pernigotto, G.; Chiacchio, F.; Borrelli, P.; D'Errico, E.

2017-11-01

This work is carried out within the FP7 European research project TOICA (Thermal Overall Integrated Conception of Aircraft, http://www.toica-fp7.eu/). One of the tasks foreseen for the TOICA project is the analysis of fuel tanks as possible heat sinks for future aircrafts. In particular, in the present paper, commercial regional aircraft is considered as case study and CFD analysis with the commercial code STAR-CCM+ is performed in order to identify the potential capability to use fuel stored in the tanks as a heat sink for waste heat dissipated by other systems. The complex physical phenomena that characterize the heat transfer inside liquid fuel, at the fuel-ullage interface and inside the ullage are outlined. Boundary conditions, including the effect of different ground and flight conditions, are implemented in the numerical simulation approach. The analysis is implemented for a portion of aluminium wing fuel tank, including the leading edge effects. Effect of liquid fuel transfer among different tank compartments and the air flow in the ullage is included. According to Fuel Tank Flammability Assessment Method (FTFAM) proposed by the Federal Aviation Administration, the results are exploited in terms of exponential time constants and fuel temperature difference to the ambient for the different cases investigated.

DebugIT for patient safety - improving the treatment with antibiotics through multimedia data mining of heterogeneous clinical data.

PubMed

Lovis, Christian; Colaert, Dirk; Stroetmann, Veli N

2008-01-01

The concepts and architecture underlying a large-scale integrating project funded within the 7th EU Framework Programme (FP7) are discussed. The main objective of the project is to build a tool that will have a significant impact for the monitoring and the control of infectious diseases and antimicrobial resistances in Europe; This will be realized by building a technical and semantic infrastructure able to share heterogeneous clinical data sets from different hospitals in different countries, with different languages and legislations; to analyze large amounts of this clinical data with advanced multimedia data mining and finally apply the obtained knowledge for clinical decisions and outcome monitoring. There are numerous challenges in this project at all levels, technical, semantical, legal and ethical that will have to be addressed.

Exploring the Feasibility of Service Integration in a Low-Income Setting: A Mixed Methods Investigation into Different Models of Reproductive Health and HIV Care in Swaziland

PubMed Central

Church, Kathryn; Wringe, Alison; Lewin, Simon; Ploubidis, George B.; Fakudze, Phelele; Mayhew, Susannah H.

2015-01-01

Integrating reproductive health (RH) with HIV care is a policy priority in high HIV prevalence settings, despite doubts surrounding its feasibility and varying evidence of effects on health outcomes. The process and outcomes of integrated RH-HIV care were investigated in Swaziland, through a comparative case study of four service models, ranging from fully integrated to fully stand-alone HIV services, selected purposively within one town. A client exit survey (n=602) measured integrated care received and unmet family planning (FP) needs. Descriptive statistics were used to assess the degree of integration per clinic and client demand for services. Logistic regression modelling was used to test the hypothesis that clients at more integrated sites had lower unmet FP needs than clients in a stand-alone site. Qualitative methods included in-depth interviews with clients and providers to explore contextual factors influencing the feasibility of integrated RH-HIV care delivery; data were analysed thematically, combining deductive and inductive approaches. Results demonstrated that clinic models were not as integrated in practice as had been claimed. Fragmentation of HIV care was common. Services accessed per provider were no higher at the more integrated clinics compared to stand-alone models (p>0.05), despite reported demand. While women at more integrated sites received more FP and pregnancy counselling than stand-alone models, they received condoms (a method of choice) less often, and there was no statistical evidence of difference in unmet FP needs by model of care. Multiple contextual factors influenced integration practices, including provider de-skilling within sub-specialist roles; norms of task-oriented routinised HIV care; perceptions of heavy client loads; imbalanced client-provider interactions hindering articulation of RH needs; and provider motivation challenges. Thus, despite institutional support, factors related to the social context of care inhibited provision of fully integrated RH-HIV services in these clinics. Programmes should move beyond simplistic training and equipment provision if integrated care interventions are to be sustained. PMID:25978632

Fuzzy-PI-based centralised control of semi-isolated FP-SEPIC/ZETA BDC in a PV/battery hybrid system

NASA Astrophysics Data System (ADS)

Mahendran, Venmathi; Ramabadran, Ramaprabha

2016-11-01

Multiport converters with centralised controller have been most commonly used in stand-alone photovoltaic (PV)/battery hybrid system to supply the load smoothly without any disturbances. This study presents the performance analysis of four-port SEPIC/ZETA bidirectional converter (FP-SEPIC/ZETA BDC) using various types of centralised control schemes like Fuzzy tuned proportional integral controller (Fuzzy-PI), fuzzy logic controller (FLC) and conventional proportional integral (PI) controller. The proposed FP-SEPIC/ZETA BDC with various control strategy is derived for simultaneous power management of a PV source using distributed maximum power point tracking (DMPPT) algorithm, a rechargeable battery, and a load by means of centralised controller. The steady state and the dynamic response of the FP-SEPIC/ZETA BDC are analysed using three different types of controllers under line and load regulation. The Fuzzy-PI-based control scheme improves the dynamic response of the system when compared with the FLC and the conventional PI controller. The power balance between the ports is achieved by pseudorandom carrier modulation scheme. The response of the FP-SEPIC/ZETA BDC is also validated experimentally using hardware prototype model of 500 W system. The effectiveness of the control strategy is validated using simulation and experimental results.

Uncompensated care provided by for-profit, not-for-profit, and government owned hospitals.

PubMed

Cram, Peter; Bayman, Levent; Popescu, Ioana; Vaughan-Sarrazin, Mary S; Cai, Xueya; Rosenthal, Gary E

2010-04-07

There is growing concern certain not-for-profit hospitals are not providing enough uncompensated care to justify their tax exempt status. Our objective was to compare the amount of uncompensated care provided by not-for-profit (NFP), for-profit (FP) and government owned hospitals. We used 2005 state inpatient data (SID) for 10 states to identify patients hospitalized for three common conditions: acute myocardial infarction (AMI), coronary artery bypass grafting (CABG), or childbirth. Uncompensated care was measured as the proportion of each hospital's total admissions for each condition that were classified as being uninsured. Hospitals were categorized as NFP, FP, or government owned based upon data obtained from the American Hospital Association. We used bivariate methods to compare the proportion of uninsured patients admitted to NFP, FP and government hospitals for each diagnosis. We then used generalized linear mixed models to compare the percentage of uninsured in each category of hospital after adjusting for the socioeconomic status of the markets each hospital served. Our cohort consisted of 188,117 patients (1,054 hospitals) hospitalized for AMI, 82,261 patients (245 hospitals) for CABG, and 1,091,220 patients for childbirth (793 hospitals). The percentage of admissions classified as uninsured was lower in NFP hospitals than in FP or government hospitals for AMI (4.6% NFP; 6.0% FP; 9.5% government; P < .001), CABG (2.6% NFP; 3.3% FP; 7.0% government; P < .001), and childbirth (3.1% NFP; 4.2% FP; 11.8% government; P < .001). In adjusted analyses, the mean percentage of AMI patients classified as uninsured was similar in NFP and FP hospitals (4.4% vs. 4.3%; P = 0.71), and higher for government hospitals (6.0%; P < .001 for NFP vs. government). Likewise, results demonstrated similar proportions of uninsured patients in NFP and FP hospitals and higher levels of uninsured in government hospitals for both CABG and childbirth. For the three conditions studied NFP and FP hospitals appear to provide a similar amount of uncompensated care while government hospitals provide significantly more. Concerns about the amount of uncompensated care provided by NFP hospitals appear warranted.

An integrated Diet Monitoring Solution for nutrigenomic research.

PubMed

Conti, Costanza; Rossi, Elena; Marceglia, Sara; Tauro, Vittorio; Rizzi, Federica; Lazzaroni, Monica; Barlassina, Cristina; Soldati, Laura; Cusi, Daniele

2015-01-01

The emergence of evidence pointing at diet as key risk factor for chronic diseases and at gene-diet interactions as key elements in the interplay between an individual genetic background and his/her lifestyle, pave the way for studies in nutrigenomics. Such studies need an integrated solution to collect, monitor and analyse a large set of data. In the frame of ATHENA, a European Commission FP7 project, we developed an integrated platform, called Dietary Monitoring Solution enabling the collection of phenotypic, genetic and lifestyle information, linked to a mHealth application tool. The data collection solution allows maintaining anonymized information and supports a number of features making it particularly suited for multicentre studies. The mHealth application was designed to translate the knowledge generated from research into a personalised prevention programme and to support the patient adherence to the programme.

Self-reliance through FP program.

PubMed

1988-03-01

The Yogyakarta Chapter of the Indonesian Planned Parenthood Association (IPPA), having been successful in bringing about a realization by the local community of the importance of family planning, has broadened its activities in an effort to further promote family welfare. Since 1980, the organization has begun a number of projects designed to increase the income of its client population. Given the fact that family planning acceptors of IPPA's Yogyakarta Chapter range from government officials' wives to farmers and school dropouts, its family income increase projects have been varied. Skills in such areas as bee breeding and hairdressing have been taught, and credit cooperatives have been established. These projects have been integrated with the group's family planning activities and have been paid for entirely with local funds. An integrated family planning/income increase project currently being operated by the Yogyakarta Chapter of IPPA is known as KBP2K. Along with the attempt to increase family income, the project aims to expand the acceptance of family planning and to retain existing acceptors in the family planning program. As of the 3rd quarter of 1987, 235 people had participated in the project and 59 new acceptors had been acquired. Family planning education was provided and classes were taught in various handicraft industries. Studies have revealed that the income levels of program participants significantly increased.

Benefits of family planning: an assessment of women's knowledge in rural Western Kenya.

PubMed

Mutombo, Namuunda; Bakibinga, Pauline; Mukiira, Carol; Kamande, Eva

2014-03-18

The last two decades have seen an increase in literature reporting an increase in knowledge and use of contraceptives among individuals and couples in Kenya, as in the rest of Africa, but there is a dearth of information regarding knowledge about benefits of family planning (FP) in Kenya. To assess the factors associated with knowledge about the benefits of FP for women and children, among women in rural Western Kenya. Data are drawn from the Packard Western Kenya Project Baseline Survey, which collected data from rural women (aged 15-49 years). Ordinal regression was used on 923 women to determine levels of knowledge and associated factors regarding benefits of FP. Women in rural Western Kenya have low levels of knowledge about benefits of FP and are more knowledgeable about benefits for the mother rather than for the child. Only age, spousal communication and type of contraceptive method used are significant. Women's level of knowledge about benefits of FP is quite low and may be one of the reasons why fertility is still high in Western Kenya. Therefore, FP programmes need to focus on increasing women's knowledge about the benefits of FP in this region.

Changing pattern of landslide risk in Europe - The SafeLand project

NASA Astrophysics Data System (ADS)

Nadim, F.; Kalsnes, B. G.; SafeLand Research Consortium

2011-12-01

The changing pattern of landslide hazard and risk caused by climate change and changes in demography, the need to protect people and property, the reality for society in Europe to live with hazard and risk and the need to manage risk were the motives for the project SafeLand: "Living with landslide risk in Europe: Assessment, effects of global change, and risk management strategies." SafeLand is a large, integrating research project under the European Commission's 7th Framework Programme (FP7). It started on 1 May 2009 and will go on for 3 years, ending on 30 April 2012. There project involves 27 partners from 12 European countries, and has international collaborators and advisers from China, India, USA, Japan and Hong Kong. SafeLand also involves 25 End-Users from 11 countries. SafeLand is coordinated by the International Centre for Geohazards (ICG) at Norwegian Geotechnical Institute in Norway. Further information on the SafeLand project can be found at its web site http://www.safeland-fp7.eu/ . SafeLand is an ongoing project, which results will be finalized in 2012. This lecture summarizes the SafeLand's activities and achievements until November 2011. The main results achieved so far include: - Development and testing of several empirical methods for predicting the characteristics of threshold rainfall events for triggering of precipitation-induced landslides. - Identification of landslide hazard and risk hotspots by an objective, GIS-based analysis for Europe. The results show clearly where landslides pose the largest hazard in Europe and the objective approach allows a ranking of the countries by exposed area and population. - Different regional climate model simulations over Europe (from the EU FP6 project ENSEMBLES) at a spatial resolution of 25 x 25 km have been used to perform an extreme value analysis for trends in heavy precipitation events. In winter a general trend towards more heavy precipitation events across all analyzed regional climate model simulations is found. For summer, a slight increase of heavy precipitation in Northern Europe and a general decrease in southern Europe is found in all regional climate model simulations. - The prototype of a web-based "toolbox" of innovative and technically appropriate prevention and mitigation measures was developed. The toolbox does a preliminary assessment and ranking of up to 60 structural and non-structural landslide risk mitigation options. - Development of an empirical model for assessing the changes in landslide frequency (hazard) as a function of changes in the demography and population density. - Case histories and "hotspots" of European Land¬slides have been collected and documented. Data for 41 potential case study sites have been compiled and summarized. These comprise 39 sites in Europe located in Italy, France, Norway, Switzerland, Austria, Andorra, and Romania; as well as one site in Canada and one in India. Almost every type of landslide and every type of movement is represented in these sites. - Research on stakeholder workshops and participatory processes to involve the population exposed to landslide risk in the decision-making process for choosing the most appropriate risk mitigation measure(s).

Advance care planning and physician orders in nursing home residents with dementia: a nationwide retrospective study among professional caregivers and relatives.

PubMed

Vandervoort, An; Houttekier, Dirk; Van den Block, Lieve; van der Steen, Jenny T; Vander Stichele, Robert; Deliens, Luc

2014-02-01

Advance care planning (ACP) is key to good palliative care for nursing home (NH) residents with dementia. We examined the extent to which the family physicians (FPs), nurses, and the relative most involved in the resident's care are informed about ACP, written advance directives, and FP treatment orders (FP-orders) for NH residents dying with dementia. We also examined the congruence among FP, nurse, and relative regarding the content of ACP. This was a representative nationwide post-mortem study (2010) in Flanders, Belgium, using random cluster sampling. In selected NHs, all deaths of residents with dementia in a three month period were reported. A structured questionnaire was completed by the FP, the nurse, and the patient's relative. We identified 205 deceased residents with dementia in 69 NHs. Residents expressed their wishes regarding end-of-life care in 11.8% of cases according to the FP. The FP and nurse spoke with the resident in 22.0% and 9.7% of cases, respectively, and with the relative in 70.6% and 59.5%, respectively. An advance directive was present in 9.0%, 13.6%, and 18.4% of the cases according to the FP, nurse, and the relative, respectively. The FP-orders were present in 77.3% according to the FP, and discussed with the resident in 13.0% and with the relative in 79.3%. Congruence was fair (FP-nurse) on the documentation of FP-orders (k=0.26), and poor to slight on the presence of an advance directive (FP-relative, k=0.03; nurse-relative, k=-0.05; FP-nurse k=0.12). Communication regarding care is rarely patient driven and more often professional caregiver or family driven. The level of congruence between professional caregivers and relatives is low. Copyright © 2014 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

Measurements at FP3 in support of pecan scientific objectives using MPL-111 lidar

NASA Astrophysics Data System (ADS)

Pozsonyi, Kristen; Midzak, Natalie; Prestine, Christina; Clark, Richard

2018-04-01

This paper will report on the data collected by a Sigma Space Micropulse Lidar (MPL-111), and how these measurements, when integrated with other data, helps to inform our analysis of two cases of the Great Plains nocturnal Low-Level Jet (LLJ) in the vicinity of FP3.

Fertility intentions and interest in integrated family planning services among women living with HIV in Nyanza Province, Kenya: a qualitative study.

PubMed

Harrington, Elizabeth K; Newmann, Sara J; Onono, Maricianah; Schwartz, Katie D; Bukusi, Elizabeth A; Cohen, Craig R; Grossman, Daniel

2012-01-01

Despite increasing efforts to address the reproductive health needs of people living with HIV, a high unmet need for contraception exists among HIV+ women in sub-Saharan Africa. This study explores the fertility intentions and family planning (FP) preferences of Kenyan women accessing HIV treatment. We conducted 30 semistructured interviews and qualitatively analyzed the data with a grounded theory approach. Fears of premature death, financial hardship, and perinatal HIV transmission emerged as reasons for participants' desire to delay/cease childbearing. Participants strongly identified FP needs, yet two-thirds were using male condoms alone or no modern method of contraception. Women preferred the HIV clinic as the site of FP access for reasons of convenience, provider expertise, and a sense of belonging, though some had privacy concerns. Our findings support the acceptability of integrated FP and HIV services. Efforts to empower women living with HIV to prevent unintended pregnancies must expand access to contraceptive methods, provide confidential services, and take into account women's varied reproductive intentions.

Aging Alters Functionally Human Dermal Papillary Fibroblasts but Not Reticular Fibroblasts: A New View of Skin Morphogenesis and Aging

PubMed Central

Mine, Solène; Fortunel, Nicolas O.; Pageon, Hervé; Asselineau, Daniel

2008-01-01

Understanding the contribution of the dermis in skin aging is a key question, since this tissue is particularly important for skin integrity, and because its properties can affect the epidermis. Characteristics of matched pairs of dermal papillary and reticular fibroblasts (Fp and Fr) were investigated throughout aging, comparing morphology, secretion of cytokines, MMPs/TIMPs, growth potential, and interaction with epidermal keratinocytes. We observed that Fp populations were characterized by a higher proportion of small cells with low granularity and a higher growth potential than Fr populations. However, these differences became less marked with increasing age of donors. Aging was also associated with changes in the secretion activity of both Fp and Fr. Using a reconstructed skin model, we evidenced that Fp and Fr cells do not possess equivalent capacities to sustain keratinopoiesis. Comparing Fp and Fr from young donors, we noticed that dermal equivalents containing Fp were more potent to promote epidermal morphogenesis than those containing Fr. These data emphasize the complexity of dermal fibroblast biology and document the specific functional properties of Fp and Fr. Our results suggest a new model of skin aging in which marked alterations of Fp may affect the histological characteristics of skin. PMID:19115004

An integrated, open-source set of tools for urban vulnerability monitoring from Earth observation data

NASA Astrophysics Data System (ADS)

De Vecchi, Daniele; Harb, Mostapha; Dell'Acqua, Fabio; Aurelio Galeazzo, Daniel

2015-04-01

Aim: The paper introduces an integrated set of open-source tools designed to process medium and high-resolution imagery with the aim to extract vulnerability indicators [1]. Problem: In the context of risk monitoring [2], a series of vulnerability proxies can be defined, such as the extension of a built-up area or buildings regularity [3]. Different open-source C and Python libraries are already available for image processing and geospatial information (e.g. OrfeoToolbox, OpenCV and GDAL). They include basic processing tools but not vulnerability-oriented workflows. Therefore, it is of significant importance to provide end-users with a set of tools capable to return information at a higher level. Solution: The proposed set of python algorithms is a combination of low-level image processing and geospatial information handling tools along with high-level workflows. In particular, two main products are released under the GPL license: source code, developers-oriented, and a QGIS plugin. These tools were produced within the SENSUM project framework (ended December 2014) where the main focus was on earthquake and landslide risk. Further development and maintenance is guaranteed by the decision to include them in the platform designed within the FP 7 RASOR project . Conclusion: With the lack of a unified software suite for vulnerability indicators extraction, the proposed solution can provide inputs for already available models like the Global Earthquake Model. The inclusion of the proposed set of algorithms within the RASOR platforms can guarantee support and enlarge the community of end-users. Keywords: Vulnerability monitoring, remote sensing, optical imagery, open-source software tools References [1] M. Harb, D. De Vecchi, F. Dell'Acqua, "Remote sensing-based vulnerability proxies in the EU FP7 project SENSUM", Symposium on earthquake and landslide risk in Central Asia and Caucasus: exploiting remote sensing and geo-spatial information management, 29-30th January 2014, Bishkek, Kyrgyz Republic. [2] UNISDR, "Living with Risk", Geneva, Switzerland, 2004. [3] P. Bisch, E. Carvalho, H. Degree, P. Fajfar, M. Fardis, P. Franchin, M. Kreslin, A. Pecker, "Eurocode 8: Seismic Design of Buildings", Lisbon, 2011. (SENSUM: www.sensum-project.eu, grant number: 312972 ) (RASOR: www.rasor-project.eu, grant number: 606888 )

Estimating the impact of +2 degrees of global warming on European Tourism

NASA Astrophysics Data System (ADS)

Tsanis, Ioannis; Koutroulis, Aristeidis; Grillakis, Manolis; Konstantopoulos, Konstantinos; Jacob, Daniela

2014-05-01

The impact of a potential global temperature rise by 2oC on tourism is examined, within the framework of IMPACT2C FP7 project. The period of the specific increase was defined according to the global mean temperature projections from two GCM, BCM and HadCM3Q3. Simulations from two RCMs, driven by the aforementioned GCMs, in the frame of ENSEMBLES FP6 under A1B emission scenario were used to estimate the Tourism Climatic Index (TCI) which is a measure of climate favorability for outdoor leisure and recreational activities. Climate favorability related to summer tourism is expected to increase in most European countries moving from south to north. In the opposite, countries that traditionally attract "sun and sand" tourists like Italy, Spain, Greece, France, Portugal, Cyprus are projected to become uncomfortably hot for the months of the peak summer season. Both of the examined models provide consistent information about the direction of change, however SMHI shows a greater change in future TCI. The TCI between 1960 and 2000 was associated to bednights data, to reveal the correlation of the empirical index with a real tourism indicator. The resulted correlation function was then applied to the 2oC period, estimating the effect of the specific temperature rise to future tourism activity expressed in terms of projected bednights.

Hemorrhoids detected at colonoscopy: an infrequent cause of false-positive fecal immunochemical test results.

PubMed

van Turenhout, Sietze T; Oort, Frank A; Terhaar sive Droste, Jochim S; Coupé, Veerle M H; van der Hulst, Rene W; Loffeld, Ruud J; Scholten, Pieter; Depla, Annekatrien C T M; Bouman, Anneke A; Meijer, Gerrit A; Mulder, Chris J J; van Rossum, Leo G M

2012-07-01

Colorectal cancer screening by fecal immunochemical tests (FITs) is hampered by frequent false-positive (FP) results and thereby the risk of complications and strain on colonoscopy capacity. Hemorrhoids might be a plausible cause of FP results. To determine the contribution of hemorrhoids to the frequency of FP FIT results. Retrospective analysis from prospective cohort study. Five large teaching hospitals, including 1 academic hospital. All subjects scheduled for elective colonoscopy. FIT before bowel preparation. Frequency of FP FIT results in subjects with hemorrhoids as the only relevant abnormality compared with FP FIT results in subjects with no relevant abnormalities. Logistic regression analysis to determine colonic abnormalities influencing FP results. In 2855 patients, 434 had positive FIT results: 213 had advanced neoplasia and 221 had FP results. In 9 individuals (4.1%; 95% CI, 1.4-6.8) with an FP FIT result, hemorrhoids were the only abnormality. In univariate unadjusted analysis, subjects with hemorrhoids as the only abnormality did not have more positive results (9/134; 6.7%) compared with subjects without any abnormalities (43/886; 4.9%; P = .396). Logistic regression identified hemorrhoids, nonadvanced polyps, and a group of miscellaneous abnormalities, all significantly influencing false positivity. Of 1000 subjects with hemorrhoids, 67 would have FP results, of whom 18 would have FP results because of hemorrhoids only. Potential underreporting of hemorrhoids; high-risk individuals. Hemorrhoids in individuals participating in colorectal cancer screening will probably not lead to a substantial number of false-positive test results. Copyright © 2012 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

The Guardian. Volume 13, Issue 1, Spring 2011

DTIC Science & Technology

2011-01-01

PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES...Furthermore, there were no AT standards pertaining to design, material, or construction of new and existing buildings ; building standoff requirements; or...installations or forward-deployed areas; DOD-wide anti¬terrorism building standards for construction , standoff, and so forth; and regular FP exercises held at

Hybrid coconut seedlings, scholarships, and discount cards for family planning acceptors.

PubMed

Sumarsono

1989-10-01

Having learned from failed family planning (FP) incentive schemes in other countries, Indonesia implemented a reward system designed to popularize FP in the community. In order to overcome cultural opposition to FP, many countries in the 1970s opted to give incentives--money, materials, etc.--to new contraceptive acceptors and the FP workers who successfully recruited them. These countries, which oftentimes spent up to 1/4 of their program budget on incentives, saw rapid increases in the number of new acceptors. The results, however, only reflected a superficial acceptance of FP. When the incentives stopped, the number of acceptors dropped considerably. Recognizing this, the Indonesian government set out to increase FP acceptance by making the small family the norm in the community. And one of the approaches for doing so was a reward system. The goals of the reward program were: 1) to raise awareness of the recognition given to individuals or groups that have accepted FP; 2) to create pride among FP workers and new acceptors; and 3) to generate leadership in the community. Villages with high FP acceptance receive rewards such as deep-wells that provide clean water or income generating projects. Individuals also receive rewards that sometimes include hybrid coconut seedlings which, after 3 years, can yield up to 700 coconuts, which can provide a family with a significant supplemental income. The government also gives scholarships to children of FP acceptors. Also, the president of Indonesia publicly recognized family planning acceptors. In 1989, over 800,000 couples received awards for practicing contraception over the past 5-16 years.

Situation analysis study establishes baseline for future assessment of progress in Senegal.

PubMed

1995-08-01

A situation analysis study was conducted by the National Family Planning Program of the Senegalese Ministry of Health and Social Action, with technical assistance from the Population Council's Africa OR/TA Project II, to evaluate the availability, functioning, and quality of family planning (FP) services at all 180 functional Service Delivery Points (SDPs) of Senegal's ten regions. Almost one-third of the SDPs had not received a supervisory visit in the seven months prior to the study, and an additional one-fifth had had no supervisory visits at all. 6% had written job descriptions for their personnel, 8% had a plan of activities, and 2% had an objective in terms of the number of clients to serve. Clinic infrastructure was generally satisfactory, although electricity and water were lacking in 30% of SDPs in rural areas. Six out of 87 SDPs in the urban sector had the minimum equipment needed. The majority of FP providers were midwives whose formal training had been limited to the management of pills and IUDs; 32% of providers had no training in administering injectables. Information, education, and communication materials were unavailable at most SDPs. 6% featured FP talks on site on the day of the research visit; six out of ten lacked a visible sign indicating the availability of FP services. On average, FP services were available four days a week, but 53% of the SDPs started services an hour late on the day of the research visit, and many were limited to four hours of service per day. 67% provided injectables, and 78% supplied IUDs. Inadequate management of contraceptive stock was partly responsible for method shortages. Records were incomplete. 81% of new clients had access to and obtained their preferred contraceptive method; however, other appropriate methods were not discussed during consultations, and counseling on method side effects was inadequate. 56% of new clients were asked about their reproductive intentions. Counseling regarding sexually transmitted diseases (STDs) and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) was practically nonexistent. Health problems found during FP consultations were rarely addressed. Non-medical barriers to the utilization of contraceptive methods existed in terms of age, parity, and marital status. Client waiting time was long, while consultation time was short. Most women had follow-up dates on their identification cards; 95% were told to return for supplies. The majority of clients were generally satisfied.

Eyelid Opening with Trigeminal Proprioceptive Activation Regulates a Brainstem Arousal Mechanism.

PubMed

Matsuo, Kiyoshi; Ban, Ryokuya; Hama, Yuki; Yuzuriha, Shunsuke

2015-01-01

Eyelid opening stretches mechanoreceptors in the supratarsal Müller muscle to activate the proprioceptive fiber supplied by the trigeminal mesencephalic nucleus. This proprioception induces reflex contractions of the slow-twitch fibers in the levator palpebrae superioris and frontalis muscles to sustain eyelid and eyebrow positions against gravity. The cell bodies of the trigeminal proprioceptive neurons in the mesencephalon potentially make gap-junctional connections with the locus coeruleus neurons. The locus coeruleus is implicated in arousal and autonomic function. Due to the relationship between arousal, ventromedial prefrontal cortex, and skin conductance, we assessed whether upgaze with trigeminal proprioceptive evocation activates sympathetically innervated sweat glands and the ventromedial prefrontal cortex. Specifically, we examined whether 60° upgaze induces palmar sweating and hemodynamic changes in the prefrontal cortex in 16 subjects. Sweating was monitored using a thumb-mounted perspiration meter, and prefrontal cortex activity was measured with 45-channel, functional near-infrared spectroscopy (fNIRS) and 2-channel NIRS at Fp1 and Fp2. In 16 subjects, palmar sweating was induced by upgaze and decreased in response to downgaze. Upgaze activated the ventromedial prefrontal cortex with an accumulation of integrated concentration changes in deoxyhemoglobin, oxyhemoglobin, and total hemoglobin levels in 12 subjects. Upgaze phasically and degree-dependently increased deoxyhemoglobin level at Fp1 and Fp2, whereas downgaze phasically decreased it in 16 subjects. Unilateral anesthetization of mechanoreceptors in the supratarsal Müller muscle used to significantly reduce trigeminal proprioceptive evocation ipsilaterally impaired the increased deoxyhemoglobin level by 60° upgaze at Fp1 or Fp2 in 6 subjects. We concluded that upgaze with strong trigeminal proprioceptive evocation was sufficient to phasically activate sympathetically innervated sweat glands and appeared to induce rapid oxygen consumption in the ventromedial prefrontal cortex and to rapidly produce deoxyhemoglobin to regulate physiological arousal. Thus, eyelid opening with trigeminal proprioceptive evocation may activate the ventromedial prefrontal cortex via the mesencephalic trigeminal nucleus and locus coeruleus.

Eyelid Opening with Trigeminal Proprioceptive Activation Regulates a Brainstem Arousal Mechanism

PubMed Central

Matsuo, Kiyoshi; Ban, Ryokuya; Hama, Yuki; Yuzuriha, Shunsuke

2015-01-01

Eyelid opening stretches mechanoreceptors in the supratarsal Müller muscle to activate the proprioceptive fiber supplied by the trigeminal mesencephalic nucleus. This proprioception induces reflex contractions of the slow-twitch fibers in the levator palpebrae superioris and frontalis muscles to sustain eyelid and eyebrow positions against gravity. The cell bodies of the trigeminal proprioceptive neurons in the mesencephalon potentially make gap-junctional connections with the locus coeruleus neurons. The locus coeruleus is implicated in arousal and autonomic function. Due to the relationship between arousal, ventromedial prefrontal cortex, and skin conductance, we assessed whether upgaze with trigeminal proprioceptive evocation activates sympathetically innervated sweat glands and the ventromedial prefrontal cortex. Specifically, we examined whether 60° upgaze induces palmar sweating and hemodynamic changes in the prefrontal cortex in 16 subjects. Sweating was monitored using a thumb-mounted perspiration meter, and prefrontal cortex activity was measured with 45-channel, functional near-infrared spectroscopy (fNIRS) and 2-channel NIRS at Fp1 and Fp2. In 16 subjects, palmar sweating was induced by upgaze and decreased in response to downgaze. Upgaze activated the ventromedial prefrontal cortex with an accumulation of integrated concentration changes in deoxyhemoglobin, oxyhemoglobin, and total hemoglobin levels in 12 subjects. Upgaze phasically and degree-dependently increased deoxyhemoglobin level at Fp1 and Fp2, whereas downgaze phasically decreased it in 16 subjects. Unilateral anesthetization of mechanoreceptors in the supratarsal Müller muscle used to significantly reduce trigeminal proprioceptive evocation ipsilaterally impaired the increased deoxyhemoglobin level by 60° upgaze at Fp1 or Fp2 in 6 subjects. We concluded that upgaze with strong trigeminal proprioceptive evocation was sufficient to phasically activate sympathetically innervated sweat glands and appeared to induce rapid oxygen consumption in the ventromedial prefrontal cortex and to rapidly produce deoxyhemoglobin to regulate physiological arousal. Thus, eyelid opening with trigeminal proprioceptive evocation may activate the ventromedial prefrontal cortex via the mesencephalic trigeminal nucleus and locus coeruleus. PMID:26244675

21st Century Climate Change in the European Alps

NASA Astrophysics Data System (ADS)

Gobiet, Andreas; Kotlarski, Sven; Stoffel, Markus; Heinrich, Georg; Rajczak, Jan; Beniston, Martin

2014-05-01

The Alps are particularly sensitive to global warming and warmed twice as much as the global average in the recent past. In addition, the Alps and its surroundings are a densly populated areas where society is affected by climate change in many ways, which calls for reliable estimates of future climate change. However, the complex Alpine region poses considerable challenges to climate models, which translate to uncertainties in future climate projections. Against this background, the present study reviews the state-of-knowledge about 21st century climate change in the Alps based on existing literature and additional analyses. It will be demonstrated that considerable and accelerating changes are not only to be expected with regard to temperature, but also precipitation, global radiation, relative humidity, and closely related impacts like floods, droughts, snow cover, and natural hazards will be effected by global warming. Under the A1B emission scenario, about 0.25 °C warming per decade until the mid of the 21st century and accelerated 0.36 °C warming per decade in the second half of the century is expected. Warming will most probably be associated with changes in the seasonality of precipitation, global radiation, and relative humidity. More intense precipitation extremes and flooding potential are particularly expected in the colder part of the year. The conditions of currently record breaking warm or hot winter or summer seasons, respectively, may become normal at the end of the 21st century, and there is indication for droughts to become more severe in the future. Snow cover is expected to drastically decrease below 1500 - 2000 m and natural hazards related to glacier and permafrost retreat are expected to become more frequent. Such changes in climatic variables and related quantities will have considerable impact on ecosystems and society and will challenge their adaptive capabilities. Acknowledgements: This study has been initiated and is partly funded by the EU FP6 project ACQWA (www.acqwa.ch). Additional funding has been provided by the project ARNICA (http://www.lgp.cnrs-bellevue.fr/arnica/), funded under the EU CIRCLE-2 mountain call, by the Swiss National Science Foundation through the Sinergia project TEMPS, and the Austrian Climate Research Program (ACRP) through the projects reclip:century and DEUCALION. We acknowledge the RCM data sets from the EU- FP6 project ENSEMBLES (http://ensembles-eu.metoffice.com). In particular, we thank Sebastian R. Scher (University of Graz) for the preparation of several figures in this study.This study has been supported by the EU project ACQWA (FP7 no. 212250) and the ACRP project reclip:century 2 (No. A963768).

OCT Angiographic Findings in Glucose-6-Phosphate Dehydrogenase Deficiency.

PubMed

Jiang, Shangjun; Choudhry, Netan

2017-08-01

Fovea plana (FP) describes the abnormal absence of the foveal pit in the retina. It is a sign that is associated with prematurity, albinism, and other ophthalmic disorders. The authors present the optical coherence tomography angiographic findings in a case of a 19-year-old male with FP and glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency is a very common condition that typically presents with hemolytic anemia and jaundice. G6PD deficiency is also known to affect vision, but these pathologies have been less well-characterized. To the authors' knowledge, this is the first report of G6PD deficiency in FP. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:664-667.]. Copyright 2017, SLACK Incorporated.

European Union Framework Programme 7 Building the Europe of Knowledge

NASA Astrophysics Data System (ADS)

Akkaş, Nuri

In March 2000, the Lisbon European Council set the goal of becoming by 2010 "the most competitive and dynamic knowledge-based economy in the world, capable of sustainable economic growth with more and better jobs and greater social cohesion". This was called the Lisbon Strategy. The project of creating a European Research Area (ERA) was endorsed as a central element of the Lisbon Strategy to achieve this goal. However, EU still invests too little in R & D. In 2003, top 500 private R & D spenders in EU decreased their R & D investment by 2.0%. Top 500 private R & D spenders outside EU increased their R & D investment by 3.9%. Overall R &D investments are as follows: EU: 1.96%; US: 2.59%; S. Korea: 2.91%; Japan: 3.12%. ERA is implemented through so-called Framework Programmes (FP). FP7 is proposed on the basis of a doubling of funds and the duration is 7 years (2007-13). FP7 will fund R& D projects of immediate industrial relevance & needs of industry. Projects will include both public research institutions and private companies (PPP).

Drug Resistance in Malaria. Investigation of Mechanisms and Patterns of Drug Resistance and Cross Resistance in Malaria.

DTIC Science & Technology

1985-01-31

incubation of erythrocytes with the oxidant drug, menadione , the values were 50.7 for G6PD-deficient and DO I ?B 1473 EDITION OF I NOV 65 IS OBSOLETE...FP which is accessible to bind chloroquine is available to lyse cells, we conclude that FP is available to mediate menadione -induced hemolysis and the...toxicity of menadione for Plasmodium falciparum parasites growing in G6PD- deficient erythrocytes. We also propose that accumulation of FP may

The overview of the radon and environmental characteristics measurements in the Czech show caves.

PubMed

Thinová, L; Froňka, A; Rovenská, K

2015-06-01

This paper focuses on the measurement and assessment of absorbed doses of radiation in caves of the Czech Republic, some of which exhibit high activity concentration of radon in air. Presented is an analysis and recommendations based on measurement results obtained in the underground caves over the past 12 y. The most important results for cave environments were as follows: integral radon monitoring using RAMARN detectors can provide more consistent results for calculating the effective dose; no major differences were shown in the average radon activity concentration during working time as opposed to non-working time; the unattached fraction of radioactive particles in air ranged from 0.03 to 0.6, with arithmetical average fp = 0.13; the direct dependence between equilibrium factor F and the size of the unattached fraction fp was described using the Log-Power expression ln(1/fp) = a*ln(1/F)(b); the calculated values for coefficients a and b were 1.85 and -1.096, respectively. The individual cave factor for each investigated underground area was calculated. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson's disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging.

PubMed

Weng, Chi-Chang; Chen, Zi-An; Chao, Ko-Ting; Ee, Ting-Wei; Lin, Kun-Ju; Chan, Ming-Huan; Hsiao, Ing-Tsung; Yen, Tzu-Chen; Kung, Mei-Ping; Hsu, Ching-Han; Wey, Shiaw-Pyng

2017-01-01

18F-9-Fluoropropyl-(+)-dihydrotetrabenazine [18F-FP-(+)-DTBZ] positron emission tomography (PET) has been shown to detect dopaminergic neuron loss associated with Parkinson's disease (PD) in human and neurotoxin-induced animal models. A polyphenol compound, magnolol, was recently proposed as having a potentially restorative effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- or 6-hydroxydopamine-treated animal models. In this study, 18F-FP-(+)-DTBZ PET was used to determine the therapeutic efficacy of magnolol in an MPTP-PD mouse model that was prepared by giving an intraperitoneally (i.p.) daily dose of 25 mg/kg MPTP to male C57BL/6 mice for 5 consecutive days. Twenty-minute static 18F-FP-(+)-DTBZ PET scans were performed before MPTP treatment and 5 days after the termination of MPTP treatment to set up the baseline control. Half of the MPTP-treated mice then received a daily dose of magnolol (10 mg/kg dissolved in corn oil, i.p.) for 6 days. 18F-FP-(+)-DTBZ PET imaging was performed the day after the final treatment. All 18F-FP-(+)-DTBZ PET images were analysed and the specific uptake ratio (SUr) was calculated. Ex vivo autoradiography (ARG) and corresponding immunohistochemistry (IHC) studies were conducted to confirm the distribution of dopaminergic terminals in the striatum. The striatal SUr ratios of 18F-FP-(+)-DTBZ PET images for the Sham, the MPTP, and the MPTP + Magnolol-treated groups were 1.25 ± 0.05, 0.75 ± 0.06, and 1.00 ± 0.11, respectively (n = 4 for each group). The ex vivo 18F-FP-(+)-DTBZ ARG and IHC results correlated favourably with the PET imaging results. 18F-FP-(+)-DTBZ PET imaging suggested that magnolol post-treatment may reverse the neuronal damage in the MPTP-lesioned PD mice. In vivo imaging of the striatal vesicular monoamine transporter type 2 (VMAT2) distribution using 18F-FP-(+)-DTBZ animal PET is a useful method to evaluate the efficacy of therapeutic drugs i.e., magnolol, for the management of PD.

Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson’s disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging

PubMed Central

Chao, Ko-Ting; Ee, Ting-Wei; Lin, Kun-Ju; Chan, Ming-Huan; Hsiao, Ing-Tsung; Yen, Tzu-Chen; Kung, Mei-Ping; Hsu, Ching-Han

2017-01-01

18F-9-Fluoropropyl-(+)-dihydrotetrabenazine [18F-FP-(+)-DTBZ] positron emission tomography (PET) has been shown to detect dopaminergic neuron loss associated with Parkinson’s disease (PD) in human and neurotoxin-induced animal models. A polyphenol compound, magnolol, was recently proposed as having a potentially restorative effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- or 6-hydroxydopamine-treated animal models. In this study, 18F-FP-(+)-DTBZ PET was used to determine the therapeutic efficacy of magnolol in an MPTP–PD mouse model that was prepared by giving an intraperitoneally (i.p.) daily dose of 25 mg/kg MPTP to male C57BL/6 mice for 5 consecutive days. Twenty-minute static 18F-FP-(+)-DTBZ PET scans were performed before MPTP treatment and 5 days after the termination of MPTP treatment to set up the baseline control. Half of the MPTP-treated mice then received a daily dose of magnolol (10 mg/kg dissolved in corn oil, i.p.) for 6 days. 18F-FP-(+)-DTBZ PET imaging was performed the day after the final treatment. All 18F-FP-(+)-DTBZ PET images were analysed and the specific uptake ratio (SUr) was calculated. Ex vivo autoradiography (ARG) and corresponding immunohistochemistry (IHC) studies were conducted to confirm the distribution of dopaminergic terminals in the striatum. The striatal SUr ratios of 18F-FP-(+)-DTBZ PET images for the Sham, the MPTP, and the MPTP + Magnolol-treated groups were 1.25 ± 0.05, 0.75 ± 0.06, and 1.00 ± 0.11, respectively (n = 4 for each group). The ex vivo 18F-FP-(+)-DTBZ ARG and IHC results correlated favourably with the PET imaging results. 18F-FP-(+)-DTBZ PET imaging suggested that magnolol post-treatment may reverse the neuronal damage in the MPTP-lesioned PD mice. In vivo imaging of the striatal vesicular monoamine transporter type 2 (VMAT2) distribution using 18F-FP-(+)-DTBZ animal PET is a useful method to evaluate the efficacy of therapeutic drugs i.e., magnolol, for the management of PD. PMID:28257461

The Effect of Integrating Family Planning with a Maternal and Newborn Health Program on Postpartum Contraceptive Use and Optimal Birth Spacing in Rural Bangladesh.

PubMed

Ahmed, Saifuddin; Ahmed, Salahuddin; McKaig, Catharine; Begum, Nazma; Mungia, Jaime; Norton, Maureen; Baqui, Abdullah H

2015-09-01

Meeting postpartum contraceptive need remains a major challenge in developing countries, where the majority of women deliver at home. Using a quasi-experimental trial design, we examine the effect of integrating family planning (FP) with a community-based maternal and newborn health (MNH) program on improving postpartum contraceptive use and reducing short birth intervals <24 months. In this two-arm trial, community health workers (CHWs) provided integrated FP counseling and services during home visits along with their outreach MNH activities in the intervention arm, but provided only MNH services in the control arm. The contraceptive prevalence rate (CPR) in the intervention arm was 15 percent higher than in the control arm at 12 months, and the difference in CPRs remained statistically significant throughout the 24 months of observation. The short birth interval of less than 24 months was significantly lower in the intervention arm. The study demonstrates that it is feasible and effective to integrate FP services into a community-based MNH care program for improving postpartum contraceptive use and lengthening birth intervals. © 2015 The Population Council, Inc.

Investigating FP Tau’s protoplanetary disk structure through modeling

NASA Astrophysics Data System (ADS)

Brinjikji, Marah; Espaillat, Catherine

2017-01-01

This project presents a study aiming to understand the structure of the protoplanetary disk around FP Tau, a very young, very low mass star in the Taurus star-forming region. We have gathered existing optical, Spitzer, Herschel and submillimeter observations to construct the spectral energy distribution (SED) of FP Tau. We have used the D’Alessio et al (2006) physically self-consistent irradiated accretion disk model including dust settling to model the disk of FP Tau. Using this method, the best fit for the SED of FP Tau is a model that includes a gap located 10-20 AU away from the star. This gap is filled with optically thin dust that separates the optically thick dust in the outer disk from the optically thick dust in the inner disk. These characteristics indicate that FP Tau’s protostellar system is best classified as a pre-transitional disk. Near-infrared interferometry in the K-Band from Willson et al 2016 indicates that FP Tau has a small gap located 10-20 AU from the star, which is consistent with the model we produced, lending further support to the pre-transitional disk interpretation. The most likely explanation for the existence of a gap in the disk is a forming planet.

Learning from the past for TB drug discovery in the future

PubMed Central

Mikušová, Katarína; Ekins, Sean

2016-01-01

Tuberculosis drug discovery has shifted in recent years from a primarily target-based approach to one that uses phenotypic high-throughput screens. As examples of this, through our EU-funded FP7 collaborations, New Medicines for Tuberculosis was target-based and our more-recent More Medicines for Tuberculosis project predominantly used phenotypic screening. From these projects we have examples of success (DprE1) and failure (PimA) going from drug to target and from target to drug, respectively. It is clear that we still have much to learn about the drug targets and the complex effects of the drugs on Mycobacterium tuberculosis. We propose a more integrated approach that learns from earlier drug discovery efforts that could help to move drug discovery forward. PMID:27717850

Evaluation of Patients with Facial Palsy and Ophthalmic Sequelae: A 23-Year Retrospective Review.

PubMed

Joseph, Shannon S; Joseph, Andrew W; Smith, Jane I; Niziol, Leslie M; Musch, David C; Nelson, Christine C

2017-10-01

Facial palsy (FP) can result in serious ophthalmic sequelae including loss of vision. We describe the clinical characteristics of FP patients presenting for ophthalmologic evaluation and the timing for initiating ophthalmologic care. We performed a retrospective review of 96 consecutive FP patients presenting between 1992 and 2015 at a tertiary eye center. The main outcome measures were time interval from the diagnosis of FP and onset of ocular symptoms to the initial ophthalmologic evaluation (IOE), and the severity of exposure keratopathy and eyelid malposition on IOE. The median time interval from the diagnosis of FP to the IOE was 1.6 years (interquartile range; IQR = 0.5-9.2), and from the onset of ocular symptoms to IOE was 0.8 years (IQR = 0.3-2.3). The most common ocular symptoms were dryness (47.9%; n = 46), irritation (39.6%; n = 38), and tearing (30.2%; n = 29). A total of 26.0% (n = 25) of patients were bothered by the appearance of their eyes. Only 13.5% (n = 13) noted change in vision. On IOE, 81.6% (n = 75) of patients had punctate epithelial erosions (PEE), of which 52.3% (n = 35) had moderate to severe PEE, 3.3% (n = 3) had corneal ulcers and 2.2% (n = 2) had corneal abrasions. The average margin-reflex distance 2 was 6.4 mm (SD = 2.4) with average lagophthalmos of 3.5 mm (SD = 3.1). Among FP patients presenting for ophthalmologic evaluation, exposure keratopathy (as evidenced by PEE and corneal ulcers/abrasions) is highly prevalent and moderately severe on IOE, despite only 13.5% of patients noting decreased vision. These findings underscore the importance of timely and thorough ophthalmologic evaluation of FP patients.

Hypoxia monitoring activities within the FP7 EU-project HYPOX: diverse approaches to understand a complex phenomenon

NASA Astrophysics Data System (ADS)

Janssen, F.; Waldmann, C.; Boetius, A.

2012-04-01

Hypoxic conditions in aquatic systems and the occurrence of 'dead zones' increase worldwide due to man-made eutrophication and global warming with consequences for biodiversity, ecosystem functions and services such as fisheries, aquaculture and tourism. Monitoring of hypoxia and its consequences has to (1) account for the appropriate temporal and spatial scales, (2) separate anthropogenic from natural drivers and long-term trends from natural variations, (3) assess ecosystem response, (4) use modeling tools for generalization and prediction, and (5) share data and obtained knowledge. In 2009 the EU FP7 project HYPOX (www.hypox.net) started out as a pioneering attempt to improve and integrate hypoxia observation capacities addressing these requirements. Target ecosystems selected for HYPOX cover a broad range of settings (e.g., hydrography, oxygenation status, biological activity, anthropogenic impact) and differ in their sensitivity towards change. Semi-enclosed basins with permanent anoxia (Black Sea, Baltic Sea), are included as well as seasonally or locally hypoxic land-locked systems (fjords, lagoons, lakes) and open ocean systems with high sensitivity to global warming (North Atlantic - Arctic transition). Adopted monitoring approaches involve autonomous, cabled, and shipboard instruments and include static and profiling moorings, benthic observatories, drifters, as well as classical CTD surveys. In order to improve observatory performance, project activities encompass developments of oxygen sensors as well as calibration procedures and technologies to reduce biofouling. Modeling and data assimilation are used to synthesize findings, to obtain an in-depth understanding of hypoxia causes and consequences, and to improve forecasting capacities. For integration of the collected information into a global oxygen observing system, results are disseminated through the HYPOX portal following GEOSS data sharing principles. This presentation will give an overview of the scientific approach of HYPOX and highlight some key results comprising findings from individual ecosystems and indentified general patterns. The driving forces that lead to hypoxia are assessed as well as consequences of oxygen depletion for aquatic life and biogeochemical processes.

EMSO ERIC - Ocean Consortium Facility for Europe and the World

NASA Astrophysics Data System (ADS)

Best, Mairi

2017-04-01

EMSO is forging ahead through the next challenge in Earth-Ocean Science: How to co-ordinate ocean data acquisition, analysis and response across provincial, national, regional, and global scales. EMSO provides power, communications, sensors, and data infrastructure for continuous, high resolution, real-time, interactive ocean observations across a truly multi- and interdisciplinary range of research areas including biology, geology, chemistry, physics, engineering, and computer science; from polar to tropical environments, through the water column down to the abyss. 11 deep sea and 4 shallow nodes span from Arctic through the Atlantic and Mediterranean, to the Black Sea. The EMSO Preparatory Phase (FP7) project led to the Interim phase (involving 13 countries) of forming the legal entity: the EMSO European Research Infrastructure Consortium (EMSO-ERIC)-officially created by the EC in 2016. The open user community, originally developed through ESONET (European Seafloor Observatory NETwork), follows on scientific community planning contributions of the ESONET-NoE (FP6) project. Further progress made through the FixO3 project (FP7) also contributes to this shared infrastructure. Coordination among nodes is being strengthened through the EMSOdev project (H2020) which is producing the EMSO Generic Instrument Module (EGIM) - standardised observations of temperature, pressure, salinity, dissolved oxygen, turbidity, chlorophyll fluorescence, currents, passive acoustics, pH, pCO2, and nutrients. Early installations are now being upgraded; in October 2015 EMSO-France deployed a second cable and junction box serving the Ligurian Sea Node in order to monitor slope stability offshore Nice; in 2016 the EMSO Azores Node receives a major upgrade that will double its observing capacity; for EMSO-Italia the Capo Passero site is being installed and the Catania site is being upgraded. EMSOLINK will continue the expansion work. EMSO is a key player in international coordination projects such as CoopEUS/Coop+, ENVRI/ENVRIplus, GOOS/EOOS - as such EMSO not only brings together countries and disciplines, but allows the pooling of resources and coordination to assemble harmonised data into a comprehensive regional ocean picture which it will then make available to researchers and stakeholders worldwide on an open and interoperable access basis.

mfpa: Extension of mfp using the ACD covariate transformation for enhanced parametric multivariable modeling.

PubMed

Royston, Patrick; Sauerbrei, Willi

2016-01-01

In a recent article, Royston (2015, Stata Journal 15: 275-291) introduced the approximate cumulative distribution (acd) transformation of a continuous covariate x as a route toward modeling a sigmoid relationship between x and an outcome variable. In this article, we extend the approach to multivariable modeling by modifying the standard Stata program mfp. The result is a new program, mfpa, that has all the features of mfp plus the ability to fit a new model for user-selected covariates that we call fp1( p 1 , p 2 ). The fp1( p 1 , p 2 ) model comprises the best-fitting combination of a dimension-one fractional polynomial (fp1) function of x and an fp1 function of acd ( x ). We describe a new model-selection algorithm called function-selection procedure with acd transformation, which uses significance testing to attempt to simplify an fp1( p 1 , p 2 ) model to a submodel, an fp1 or linear model in x or in acd ( x ). The function-selection procedure with acd transformation is related in concept to the fsp (fp function-selection procedure), which is an integral part of mfp and which is used to simplify a dimension-two (fp2) function. We describe the mfpa command and give univariable and multivariable examples with real data to demonstrate its use.

The climate4impact platform: Providing, tailoring and facilitating climate model data access

NASA Astrophysics Data System (ADS)

Pagé, Christian; Pagani, Andrea; Plieger, Maarten; Som de Cerff, Wim; Mihajlovski, Andrej; de Vreede, Ernst; Spinuso, Alessandro; Hutjes, Ronald; de Jong, Fokke; Bärring, Lars; Vega, Manuel; Cofiño, Antonio; d'Anca, Alessandro; Fiore, Sandro; Kolax, Michael

2017-04-01

One of the main objectives of climate4impact is to provide standardized web services and tools that are reusable in other portals. These services include web processing services, web coverage services and web mapping services (WPS, WCS and WMS). Tailored portals can be targeted to specific communities and/or countries/regions while making use of those services. Easier access to climate data is very important for the climate change impact communities. To fulfill this objective, the climate4impact (http://climate4impact.eu/) web portal and services has been developed, targeting climate change impact modellers, impact and adaptation consultants, as well as other experts using climate change data. It provides to users harmonized access to climate model data through tailored services. It features static and dynamic documentation, Use Cases and best practice examples, an advanced search interface, an integrated authentication and authorization system with the Earth System Grid Federation (ESGF), a visualization interface with ADAGUC web mapping tools. In the latest version, statistical downscaling services, provided by the Santander Meteorology Group Downscaling Portal, were integrated. An innovative interface to integrate statistical downscaling services will be released in the upcoming version. The latter will be a big step in bridging the gap between climate scientists and the climate change impact communities. The climate4impact portal builds on the infrastructure of an international distributed database that has been set to disseminate the results from the global climate model results of the Coupled Model Intercomparison project Phase 5 (CMIP5). This database, the ESGF, is an international collaboration that develops, deploys and maintains software infrastructure for the management, dissemination, and analysis of climate model data. The European FP7 project IS-ENES, Infrastructure for the European Network for Earth System modelling, supports the European contribution to ESGF and contributes to the ESGF open source effort, notably through the development of search, monitoring, quality control, and metadata services. In its second phase, IS-ENES2 supports the implementation of regional climate model results from the international Coordinated Regional Downscaling Experiments (CORDEX). These services were extended within the European FP7 Climate Information Portal for Copernicus (CLIPC) project, and some could be later integrated into the European Copernicus platform.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalemci, Emrah

This work summarizes the efforts in Turkey to build a laboratory capable of building and testing high energy astrophysics detectors that work in space. The EC FP6 ASTRONS project contributed strongly to these efforts, and as a result a fully operational laboratory at Sabanci University have been developed. In this laboratory we test and develop Si and CdZnTe based room temperature semiconductor strip detectors and develop detector and electronics system to be used as a payload on potential small Turkish satellites.

Availability and Reliability of Disaster Early Warning Systems and the IT Infrastructure Library

NASA Astrophysics Data System (ADS)

Wächter, J.; Loewe, P.

2012-12-01

The Boxing Day Tsunami of 2004 caused an information catastrophy. Crucial early warning information could not be delivered to the communities under imminent threat, resulting in over 240,000 casualties in 14 countries. This tragedy sparked the development of a new generation of integrated modular Tsunami Early Warning Systems (TEWS). While significant advances were accomplished in the past years, recent events, like the Chile 2010 and the Tohoku 2011 tsunami demonstrate that the key technical challenge for Tsunami Early Warning research on the supranational scale still lies in the timely issuing of status information and reliable early warning messages. A key challenge stems from the main objective of the IOC Tsunami Programme, the integration of national TEWS towards ocean-wide networks: Each of the increasing number of integrated Tsunami Early Warning Centres has to cope with the continuing evolution of sensors, hardware and software while having to maintain reliable inter-center information exchange services. To avoid future information catastrophes, the performance of all components, ranging from sensors to Warning Centers, has to be regularly validated against defined criteria. This task is complicated by the fact that in term of ICT system life cycles tsunami are very rare event resulting in very difficult framing conditions to safeguard the availability and reliability of TWS. Since 2004, GFZ German Research Centre for Geosciences (GFZ) has built up expertise in the field of TEWS. Within GFZ, the Centre for GeoInformation Technology (CEGIT) has focused its work on the geoinformatics aspects of TEWS in two projects already: The German Indonesian Tsunami Early Warning System (GITEWS) funded by the German Federal Ministry of Education and Research (BMBF) and the Distant Early Warning System (DEWS), a European project funded under the sixth Framework Programme (FP6). These developments are continued in the TRIDEC project (Collaborative, Complex, and Critical Decision Processes in Evolving Crises) funded under the European Union's seventh Framework Programme (FP7). This ongoing project focuses on real-time intelligent information management in Earth management and its long-term application. All technical development in TRIDEC is based on mature system architecture models and industry standards. The use of standards applies also to the operation of individual TRIDEC reference installations and their interlinking into an integrated service infrastructure for supranational warning services: A set of best practices for IT service management is used to align the TEWS software services with the requirements by the Early Warning Centre management by defining Service Level Agreements (SLA) and ensuring appliance. For this, the concept of service lifecycles is adapted for the TEWS domain, which is laid out in the IT Infrastructure Library (ITIL) by the United Kingdom's Office of Government Commerce (OGC). The cyclic procedures, tasks and checklists described by ITIL are used to establish a baseline to plan, implement, and maintain TEWS service components in the long run. This allows to ensure compliance with given international TEWS standards and to measure improvement of the provided services against a gold-standard.

Anti-mitochondrial flavoprotein autoantibodies of patients with myocarditis and dilated cardiomyopathy (anti-M7): interaction with flavin-carrying proteins, effect of vitamin B2 and epitope mapping

PubMed Central

Stähle, I; Brizzio, C; Barile, M; Brandsch, R

1999-01-01

Vitamin B2 and flavin cofactors are transported tightly bound to immunoglobulin in human serum. We reasoned that anti-mitochondrial flavoprotein autoantibodies (αFp-AB) present in the serum of patients with myocarditis and cardiomyopathy of unknown aetiology may form immunoglobulin aggregates with these serum proteins. However, immunodiffusion and Western blot assays demonstrated that the flavin-carrying proteins were not recognized by αFp-AB. Apparently the flavin moiety in the native protein conformation was inaccessible to αFp-AB. This conclusion was supported by the absence of an immunoreaction between the riboflavin-binding protein from egg white and αFP-AB. Intravenous application of vitamin B2 to rabbits immunized with 6-hydroxy-d-nicotine oxidase, a bacterial protein carrying covalently attached FAD, did not neutralize αFp-AB which had been raised in the serum of the animals. FAD-carrying peptides generated from 6-hydroxy-d-nicotine oxidase by trypsin and chymotrypsin treatment were not recognized by the αFp-AB, but those generated by endopeptidase Lys were. This demonstrates that the epitope recognized by αFp-AB comprises, besides the flavin moiety, protein secondary structure elements. PMID:10193410

APhoRISM FP7 project: the Multi-platform volcanic Ash Cloud Estimation (MACE) infrastructure

NASA Astrophysics Data System (ADS)

Merucci, Luca; Corradini, Stefano; Bignami, Christian; Stramondo, Salvatore

2014-05-01

APHORISM is an FP7 project that aims to develop innovative products to support the management and mitigation of the volcanic and the seismic crisis. Satellite and ground measurements will be managed in a novel manner to provide new and improved products in terms of accuracy and quality of information. The Multi-platform volcanic Ash Cloud Estimation (MACE) infrastructure will exploit the complementarity between geostationary, and polar satellite sensors and ground measurements to improve the ash detection and retrieval and to fully characterize the volcanic ash clouds from source to the atmosphere. The basic idea behind the proposed method consists to manage in a novel manner, the volcanic ash retrievals at the space-time scale of typical geostationary observations using both the polar satellite estimations and in-situ measurements. The typical ash thermal infrared (TIR) retrieval will be integrated by using a wider spectral range from visible (VIS) to microwave (MW) and the ash detection will be extended also in case of cloudy atmosphere or steam plumes. All the MACE ash products will be tested on three recent eruptions representative of different eruption styles in different clear or cloudy atmospheric conditions: Eyjafjallajokull (Iceland) 2010, Grimsvotn (Iceland) 2011 and Etna (Italy) 2011-2012. The MACE infrastructure will be suitable to be implemented in the next generation of ESA Sentinels satellite missions.

Fluticasone propionate/formoterol for COPD management: a randomized controlled trial

PubMed Central

Papi, A; Dokic, D; Tzimas, W; Mészáros, I; Olech-Cudzik, A; Koroknai, Z; McAulay, K; Mersmann, S; Dalvi, PS; Overend, T

2017-01-01

Purpose To evaluate fluticasone propionate/formoterol (FP/FORM) in COPD. Patients and methods COPD patients with forced expiratory volume in 1 s (FEV1) ≤50% predicted and ≥1 moderate/severe COPD exacerbation in the last 12 months were randomized to FP/FORM 500/20 or 250/10 µg bid, or formoterol (FORM) 12 µg bid for 52 weeks. The primary outcome was the annualized rate of moderate/severe COPD exacerbations. Results In total, 1,765 patients were randomized. There were fewer discontinuations with FP/FORM 500/20 µg (20.6%) and 250/10 µg (24.0%) compared with FORM (26.1%). None of the two FP/FORM doses reduced the moderate/severe exacerbation rate versus FORM (rate ratios [RR]: 0.93; P≤0.402). There was a trend toward a lower moderate/severe exacerbation rate with FP/FORM 500/20 µg versus FORM in patients with ≥2 exacerbations in the preceding year (RR: 0.79; P=0.084). Pre- and post-dose FEV1 and forced vital capacity were greater with FP/FORM 500/20 µg versus FORM (P≤0.039). There was a trend toward a lower EXAcerbations of Chronic pulmonary disease Tool (EXACT) exacerbation rate with FP/FORM 500/20 µg versus FORM (RR: 0.87; P=0.077). There were more St George’s Respiratory Questionnaire for COPD (SGRQ-C) responders with FP/FORM 500/20 µg than FORM (odds ratios [OR] at weeks 6, 23 and 52 ≥1.28; P≤0.054). EXACT-respiratory symptoms total and breathlessness scores were lower with both FP/FORM 500/20 µg and 250/10 µg versus FORM (P≤0.066). Acute β2-agonist-induced effects and 24-hour Holter findings were similar for all treatments. Mean 24-hour urinary cortisol was similarly reduced with both FP/FORM doses. Radiologically confirmed pneumonia was seen in 2.4%, 3.2% and 1.5% of FP/FORM 500/20 µg, FP/FORM 250/10 µg and FORM-treated patients, respectively. Adverse events were otherwise similar across treatment groups. Conclusion FP/FORM did not reduce exacerbation rates versus FORM. Numerical benefits were observed with FP/FORM 500/20 µg versus FORM for secondary variables, including lung function, EXACT exacerbations, SGRQ-C and EXACT-respiratory symptoms total and breathlessness scores. Few efficacy differences were evident between FP/FORM 250/10 µg and FORM. Pneumonia was more frequent in FP/FORM-treated patients, although the absolute difference was low. Adverse events were otherwise similar between treatments. PMID:28740376

Fluticasone propionate/formoterol for COPD management: a randomized controlled trial.

PubMed

Papi, A; Dokic, D; Tzimas, W; Mészáros, I; Olech-Cudzik, A; Koroknai, Z; McAulay, K; Mersmann, S; Dalvi, P S; Overend, T

2017-01-01

To evaluate fluticasone propionate/formoterol (FP/FORM) in COPD. COPD patients with forced expiratory volume in 1 s (FEV 1 ) ≤50% predicted and ≥1 moderate/severe COPD exacerbation in the last 12 months were randomized to FP/FORM 500/20 or 250/10 µg bid, or formoterol (FORM) 12 µg bid for 52 weeks. The primary outcome was the annualized rate of moderate/severe COPD exacerbations. In total, 1,765 patients were randomized. There were fewer discontinuations with FP/FORM 500/20 µg (20.6%) and 250/10 µg (24.0%) compared with FORM (26.1%). None of the two FP/FORM doses reduced the moderate/severe exacerbation rate versus FORM (rate ratios [RR]: 0.93; P ≤0.402). There was a trend toward a lower moderate/severe exacerbation rate with FP/FORM 500/20 µg versus FORM in patients with ≥2 exacerbations in the preceding year (RR: 0.79; P =0.084). Pre- and post-dose FEV 1 and forced vital capacity were greater with FP/FORM 500/20 µg versus FORM ( P ≤0.039). There was a trend toward a lower EXAcerbations of Chronic pulmonary disease Tool (EXACT) exacerbation rate with FP/FORM 500/20 µg versus FORM (RR: 0.87; P =0.077). There were more St George's Respiratory Questionnaire for COPD (SGRQ-C) responders with FP/FORM 500/20 µg than FORM (odds ratios [OR] at weeks 6, 23 and 52 ≥1.28; P ≤0.054). EXACT-respiratory symptoms total and breathlessness scores were lower with both FP/FORM 500/20 µg and 250/10 µg versus FORM ( P ≤0.066). Acute β 2 -agonist-induced effects and 24-hour Holter findings were similar for all treatments. Mean 24-hour urinary cortisol was similarly reduced with both FP/FORM doses. Radiologically confirmed pneumonia was seen in 2.4%, 3.2% and 1.5% of FP/FORM 500/20 µg, FP/FORM 250/10 µg and FORM-treated patients, respectively. Adverse events were otherwise similar across treatment groups. FP/FORM did not reduce exacerbation rates versus FORM. Numerical benefits were observed with FP/FORM 500/20 µg versus FORM for secondary variables, including lung function, EXACT exacerbations, SGRQ-C and EXACT-respiratory symptoms total and breathlessness scores. Few efficacy differences were evident between FP/FORM 250/10 µg and FORM. Pneumonia was more frequent in FP/FORM-treated patients, although the absolute difference was low. Adverse events were otherwise similar between treatments.

The Heliophysics Integrated Observatory

NASA Astrophysics Data System (ADS)

Csillaghy, A.; Bentley, R. D.

2009-12-01

HELIO is a new Europe-wide, FP7-funded distributed network of services that will address the needs of a broad community of researchers in heliophysics. This new research field explores the “Sun-Solar System Connection” and requires the joint exploitation of solar, heliospheric, magnetospheric and ionospheric observations. HELIO will provide the most comprehensive integrated information system in this domain; it will coordinate access to the distributed resources needed by the community, and will provide access to services to mine and analyse the data. HELIO will be designed as a Service-oriented Architecture. The initial infrastructure will include services based on metadata and data servers deployed by the European Grid of Solar Observations (EGSO). We will extend these to address observations from all the disciplines of heliophysics; differences in the way the domains describe and handle the data will be resolved using semantic mapping techniques. Processing and storage services will allow the user to explore the data and create the products that meet stringent standards of interoperability. These capabilities will be orchestrated with the data and metadata services using the Taverna workflow tool. HELIO will address the challenges along the FP7 I3 activities model: (1) Networking: we will cooperate closely with the community to define new standards for heliophysics and the required capabilities of the HELIO system. (2) Services: we will integrate the services developed by the project and other groups to produce an infrastructure that can easily be extended to satisfy the growing and changing needs of the community. (3) Joint Research: we will develop search tools that span disciplinary boundaries and explore new types of user-friendly interfaces HELIO will be a key component of a worldwide effort to integrate heliophysics data and will coordinate closely with international organizations to exploit synergies with complementary domains.

Family Planning Vouchers in Low and Middle Income Countries: A Systematic Review

PubMed Central

Bellows, Ben; Bulaya, Carol; Inambwae, Sophie; Lissner, Craig L.; Ali, Moazzam; Bajracharya, Ashish

2016-01-01

Family planning (FP) vouchers have targeted subsidies to disadvantaged populations for quality reproductive health services since the 1960s. To summarize the effect of FP voucher programs in low‐ and middle‐income countries, a systematic review was conducted, screening studies from 33 databases through three phases: keyword search, title and abstract review, and full text review. Sixteen articles were selected including randomized control trials, controlled before‐and‐after, interrupted time series analyses, cohort, and before‐and‐after studies. Twenty‐three study outcomes were clustered around contraceptive uptake, with study outcomes including fertility in the early studies and equity and discontinuation in more recent publications. Research gaps include measures of FP quality, unintended outcomes, clients’ qualitative experiences, FP voucher integration with health systems, and issues related to scale‐up of the voucher approach. PMID:27859338

Optical RAM-enabled cache memory and optical routing for chip multiprocessors: technologies and architectures

NASA Astrophysics Data System (ADS)

Pleros, Nikos; Maniotis, Pavlos; Alexoudi, Theonitsa; Fitsios, Dimitris; Vagionas, Christos; Papaioannou, Sotiris; Vyrsokinos, K.; Kanellos, George T.

2014-03-01

The processor-memory performance gap, commonly referred to as "Memory Wall" problem, owes to the speed mismatch between processor and electronic RAM clock frequencies, forcing current Chip Multiprocessor (CMP) configurations to consume more than 50% of the chip real-estate for caching purposes. In this article, we present our recent work spanning from Si-based integrated optical RAM cell architectures up to complete optical cache memory architectures for Chip Multiprocessor configurations. Moreover, we discuss on e/o router subsystems with up to Tb/s routing capacity for cache interconnection purposes within CMP configurations, currently pursued within the FP7 PhoxTrot project.

Variable Foreperiod Deficits in Parkinson's Disease: Dissociation across Reflexive and Voluntary Behaviors

ERIC Educational Resources Information Center

Jurkowski, A.J.; Stepp, E.; Hackley, S.A.

2005-01-01

The effect of a visual warning signal (1.0-6.5s random foreperiod, FP) on the latency of voluntary (hand-grip) and reflexive (startle-eyeblink) reactions was investigated in Parkinson's disease (PD) patients and in young and aged control subjects. Equivalent FP effects on blink were observed across groups. By contrast, FP effects diverged for…

Abbott ARCHITECT iPhenytoin assay versus similar assays for measuring free phenytoin concentrations.

PubMed

Tacker, Danyel Hermes; Robinson, Randy; Perrotta, Peter L

2014-01-01

To measure free phenytoin (FP) concentrations in filtered specimens using the Abbott ARCHITECT iPhenytoin assay and to compare results from this method with results from the Abbott TDx/FLx assays. We verified accuracy, analytic measurement range, and precision for FP measurements. For correlation and therapeutic interval studies, we used filtered calibrators, controls, proficiency-testing materials, and surplus clinical samples. After implementation, we determined proficiency testing results. The analytic measurement range was 2.0 to 25.0 micromol/L. Quality control materials (6.1, 12.6, and 20.1 micromol/L) provided mean (SD) recoveries of 96.1 (5.0%), 99.2 (5.0%), and 99.3 (5.7%), respectively, and coefficients of variation of 5.2%, 5.0%, and 5.8%, respectively. Clinical specimens produced mean (SD) FP recovery levels of 103.7 (10.6%) (bias, 0.1 [0.3] micromol/L). Altering the FP therapeutic range (4.0-8.0 micromol/L) was unnecessary. Proficiency testing yielded consistently acceptable results. Our accuracy, precision, and correlation results were similar for the TDx/FLx and ARCHITECT assays, which demonstrates that the ARCHITECT iPhenytoin assay is acceptable for clinical FP measurements.

Integration of photovoltaic and concentrated solar thermal technologies for H2 production by the hybrid sulfur cycle

NASA Astrophysics Data System (ADS)

Liberatore, Raffaele; Ferrara, Mariarosaria; Lanchi, Michela; Turchetti, Luca

2017-06-01

It is widely agreed that hydrogen used as energy carrier and/or storage media may significantly contribute in the reduction of emissions, especially if produced by renewable energy sources. The Hybrid Sulfur (HyS) cycle is considered as one of the most promising processes to produce hydrogen through the water-splitting process. The FP7 project SOL2HY2 (Solar to Hydrogen Hybrid Cycles) investigates innovative material and process solutions for the use of solar heat and power in the HyS process. A significant part of the SOL2HY2 project is devoted to the analysis and optimization of the integration of the solar and chemical (hydrogen production) plants. In this context, this work investigates the possibility to integrate different solar technologies, namely photovoltaic, solar central receiver and solar troughs, to optimize their use in the HyS cycle for a green hydrogen production, both in the open and closed process configurations. The analysis carried out accounts for different combinations of geographical location and plant sizing criteria. The use of a sulfur burner, which can serve both as thermal backup and SO2 source for the open cycle, is also considered.

Men's knowledge of and attitude with respect to family planning in a suburban Nigerian community.

PubMed

Odu, O O; Ijadunola, K T; Komolafe, J O; Adebimpe, W T

2006-01-01

Men's Knowledge of and attitudes to family planning (FP) in suburban and rural Nigeria is still poor despite a global move to increase the involvement of men in reproductive health matters. A cross-sectional survey was conducted to determine men's knowledge of and attitude to family planning at Ganmo, a sub-urban community on the outskirts of Ilorin, Nigeria. The study employed an interviewer administered semi-structured questionnaire to elicit information from 360 men in the households. Only males above the age of 15 years resident in the community were selected for interview A proportionate sampling procedure was employed in selecting the required numberof men from each of the 32 compounds that make up the community. Nearly all men (96.5%) were aware of family planning and a majority of them were aware of some common methods of family planning e.g. Oral Contraceptive Pills (OCPs) (72.5%), Injectables (69.2%), Condoms (86.6%) and Traditional methods (70.6%). Knowledge of other alternative female methods was low e.g. Norplant (17.5%), IUCD (26.3%), Diaphragm (39.8%), Vaginal cream (30.2%), Vaginal tablet (37.8%) and Vaginal sponge (16.8%), and Tubal Ligation (51.3%). Knowledge of male controlled FP methods like Withdrawal (49.6%), Rhythm or periodic abstinence (54.6%) and Vasectomy (28.6%) was also poor. The Respondents had low knowledge of common side effects of FP methods e.g. nausea (9.8%), vomiting (13.1%), abnormal menstruation (34.4%), pain (23.2%) and unwanted weight gain (17.0%); some 25.3%% of respondents had no knowledge of any side effects. The attitude of respondents to family planning was also relatively poor as only a moderate proportion of men supported the FP concept (52.7%) and the Nigerian Population Policy (54.8%) of "four children to a woman". Some 54.8% of respondents were in support of men discussing about FP with their spouses. The major reasons for non-approval of FP by men were the fear of side-effects (70.4%) and perception of FP as being against religion (52.1%). The predictors of poor FP attitude were not having formal education, practice of polygyny and to a lesser extent being a Muslim. The study concluded that, men at Ganmo have limited knowledge of, and poor attitude to FP An intensive drive at a community based adult reproductive health education was advocated among other recommendations.

Cost Analysis of Fluconazole Prophylaxis for Prevention of Neonatal Invasive Candidiasis.

PubMed

Swanson, Jonathan R; Vergales, Jeff; Kaufman, David A; Sinkin, Robert A

2016-05-01

Fluconazole prophylaxis (FP) in premature infants is well studied and has been shown to decrease invasive candidiasis (ICs). IC in neonates has significant financial costs; determining the cost-benefit of FP may provide additional justification for targeting high-risk neonates. We aimed to determine the IC rate in premature infants at which FP is cost-beneficial. A decision tree cost-analysis model using cost of FP related to costs associated with IC was used. We searched PubMed for all papers that used intravenous FP and reported rates of IC in very low birth weight neonates. Average IC rates in those who received FP (2.0%; range, 0-6.1%) and in those who did not receive FP (9.2%; range, 0-20.5%) were used. Incremental hospital costs because of IC and for FP were retrieved from the literature. Sensitivity analysis was performed to determine the incremental cost of FP across the range of published IC rates. The average cost per patient attributed to IC in patients receiving FP was $785 versus $2617 in those not receiving FP. Sensitivity analysis demonstrates the rate of IC would need to be <2.8% for FP to lose its cost-benefit. In Monte Carlo simulation, targeting infants <1000 g would lead to $50,304,333 in cost savings per year in the United States. FP provides a cost-advantage across most IC rates seen in the youngest premature infants. Using a rate of 2.8% for their individual high-risk neonatal intensive care unit patients, providers can determine if FP is cost-beneficial in determining for whom to provide IC prophylaxis.

EU Funded Research Activities on NPPS Operational Safety

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manolatos, P.; Van Goethem, G.

2002-07-01

The 5. framework programme (FP-5), the pluri-annual research programme of the European Union (EU), covers the period 1998-2002. Research on nuclear energy, fusion and fission, is covered by the EURATOM part of the FP-5. An overview of the Euratom's research on Nuclear Reactor Safety, managed by the DG-RTD of the European Commission (EC), is presented. This concerns 70 multi-partner projects of approximately euro 82.5 million total contract value that have been selected and co-financed during the period 1999-2001. They form the three clusters of projects dealing with the 'Operational Safety of Existing Installations'. 'Plant Life Extension and Management' (PLEM), 'Severemore » Accident Management' (SAM) and 'Evolutionary concepts' (EVOL). Emphasis is given here to the projects of the PLEM cluster. (authors)« less

Reproductive health service use and social determinants among the floating population: a quantitative comparative study in Guangzhou City.

PubMed

Liu, Huan; Wang, Qi; Lu, Zuxun; Liu, Junan

2014-10-30

The World Health Assembly has pledged to achieve universal reproductive health (RH) coverage by 2015. Therefore, China has been vigorously promoting the equalisation of basic public health services (i.e. RH services). The floating population (FP) is the largest special group of internal migrants in China and constitutes the current national focus. However, gaps exist in the access of this group to RH services in China. A total of 453 members of the FP and 794 members of the residential population (RP) aged 18 to 50 years from five urban districts in Guangzhou City were recruited to participate in a cross-sectional survey in 2009. Information on demographics and socioeconomic status (SES) were collected from these two groups to evaluate the utilisation of RH knowledge and skills and family planning services (FPS), and to identify social determinants. The proportion of individuals with low SES in the FP (19.2%) was higher than that in the RP (6.3%) (P <0.001). Of the FP, 9.7% to 35.8% had no knowledge of at least one skill, a proportion higher than the counterpart values (6.2% to 27.5%) for the RP (P <0.05). The frequency of FPS use among the FP and RP was low. However, FPS use was higher among the FP than among the RP (3.51 vs. 2.99) (P =0.050). Logistic regression analysis was used to analyse the social determinants that influence FPS use in the FP and RP. The factors that affect FPS utilisation of the RP included SES (OR =4.652, 95% CI =1.751, 12.362), whereas those of the FP excluded SES. The FPS use of the FP in Guangzhou City was higher under equalised public health services. However, a need still exists to help the FP with low SES to improve their RH knowledge and skills through access to public RH services.

Demand for Modern Family Planning among Married Women Living with HIV in Western Ethiopia

PubMed Central

Feyissa, Tesfaye Regassa; Melka, Alemu Sufa

2014-01-01

Introduction People living with HIV (PLHIV) have diverse family planning (FP) needs. Little is reported on FP needs among women living with HIV in Ethiopia. Thus, the objective of the study was to assess the demand for modern FP among married women living with HIV in western Ethiopia. Methods A facility-based cross-sectional survey was conducted on 401 married women living with HIV selected from Nekemte Referral Hospital and Health Center, Nekemte, Oromia, Ethiopia. Convenience sampling of every other eligible patient was used to recruit respondents. Data were collected using a pretested, structured questionnaire. We first calculated frequency and percentage of unmet need, met need and total demand by each explanatory variable, and performed chi-squared testing to assess for differences in groups. We then fitted logistic regression models to identify correlates of unmet need for modern FP at 95% CL. Results The proportion of respondents with met need for modern FP among married women living with HIV was 61.6% (30.7% for spacing and 30.9% for limiting). Demand for family planning was reported in 77.0% (38.2% for spacing and 38.8% for limiting), making unmet need for modern FP prevalent in 15.4% (7.5% for spacing and 7.9% for limiting). Whereas age 25–34 years [adjusted odds ratio (AOR) (95% confidence interval (CI))  = .397 (.204–.771)] was protective against unmet need for modern FP, not having knowledge of MTCT [AOR (95% CI)  = 2.531 (1.689–9.290)] and not discussing FP with a partner [AOR (95% CI)  = 3.616(1.869–6.996)] were associated with increased odds of unmet need for modern FP. Conclusions There is high unmet need for modern FP in HIV-positive married women in western Ethiopia. Health care providers and program managers at a local and international level should work to satisfy the unmet need for modern family planning. PMID:25390620

Demand for modern family planning among married women living with HIV in western Ethiopia.

PubMed

Feyissa, Tesfaye Regassa; Melka, Alemu Sufa

2014-01-01

People living with HIV (PLHIV) have diverse family planning (FP) needs. Little is reported on FP needs among women living with HIV in Ethiopia. Thus, the objective of the study was to assess the demand for modern FP among married women living with HIV in western Ethiopia. A facility-based cross-sectional survey was conducted on 401 married women living with HIV selected from Nekemte Referral Hospital and Health Center, Nekemte, Oromia, Ethiopia. Convenience sampling of every other eligible patient was used to recruit respondents. Data were collected using a pretested, structured questionnaire. We first calculated frequency and percentage of unmet need, met need and total demand by each explanatory variable, and performed chi-squared testing to assess for differences in groups. We then fitted logistic regression models to identify correlates of unmet need for modern FP at 95% CL. The proportion of respondents with met need for modern FP among married women living with HIV was 61.6% (30.7% for spacing and 30.9% for limiting). Demand for family planning was reported in 77.0% (38.2% for spacing and 38.8% for limiting), making unmet need for modern FP prevalent in 15.4% (7.5% for spacing and 7.9% for limiting). Whereas age 25-34 years [adjusted odds ratio (AOR) (95% confidence interval (CI)) = .397 (.204-.771)] was protective against unmet need for modern FP, not having knowledge of MTCT [AOR (95% CI) = 2.531 (1.689-9.290)] and not discussing FP with a partner [AOR (95% CI) = 3.616(1.869-6.996)] were associated with increased odds of unmet need for modern FP. There is high unmet need for modern FP in HIV-positive married women in western Ethiopia. Health care providers and program managers at a local and international level should work to satisfy the unmet need for modern family planning.

Fertility Preservation for Transgender Adolescents.

PubMed

Chen, Diane; Simons, Lisa; Johnson, Emilie K; Lockart, Barbara A; Finlayson, Courtney

2017-07-01

To describe fertility preservation (FP) utilization by transgender adolescents within a pediatric gender clinic between July 2013 and July 2016. A retrospective chart review was conducted to abstract demographic and clinical information among adolescents initiating gender-affirming hormones, including patient age at initial FP consultation, birth-assigned sex, race/ethnicity, and outcome of FP consultation. In our sample of 105 transgender adolescents, a total of 13 (seven transgender men and six transgender women) between the age of 14.2 and 20.6 years were seen in formal consultation for FP before initiating hormones. Of these adolescents, four completed sperm cryopreservation and one completed oocyte cryopreservation. Rates of FP utilization among transgender youth were low, which is consistent with a recently published report of FP utilization among transgender youth at another pediatric institution. Identified barriers to FP in our sample included cost, invasiveness of procedures, and desire not to delay medical transition. Copyright © 2017 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Fluoropyrimidines plus cisplatin versus gemcitabine/gemcitabine plus cisplatin in locally advanced and metastatic biliary tract carcinoma - a retrospective study.

PubMed

Croitoru, Adina; Gramaticu, Iulia; Dinu, Ioana; Gheorghe, Liana; Alexandrescu, Sorin; Buica, Florina; Luca, Ioana; Becheanu, Gabriel; Herlea, Vlad; Simionov, Iulia; Hrehoret, Doina; Lupescu, Ioana; Popescu, Irinel; Diculescu, Mircea

2012-09-01

This is a retrospective study of patients with advanced biliary tract carcinoma (BTC), who were treated with different regimens of chemotherapy. We studied patients with advanced BTC registered at the Department of Oncology at the Fundeni Clinical Institute between 2004 and 2008. The following data were analyzed: rate of response, progression free survival (PFS) to first and second line of chemotherapy, overall survival (OS) and drug toxicity. Ninety-six patients were eligible having either advanced intra or extrahepatic cholangiocarcinoma, or gallbladder cancer with no prior chemotherapy. Out of 96 patients, 57 (59.4%) received fluoropyrimidines (FP)+cisplatin and 39 (40.6%) gemcitabine (Gem)+/-cisplatin. The median PFS for FP+cisplatin was 5.9 months (95%CI 5-6.9) and for Gem+/-cisplatin 6.3 months (95%CI 5.4-7.1), p=0.661. Median OS for FP+cisplatin was 10.3 months (95%CI 7.5-13.1) and for Gem+/-cisplatin 9.1 months (95%CI 7.0-11.2), p=0.098. On disease progression, 46 patients received second line CT (Gem or FP+/-platinum compounds). Median OS for patients with FP based first line and Gem+/-cisplatin in second line was 19 months (95%CI 8.9-29) higher than for the reverse sequence: 13.2 months (95%CI 12-14.4), but not statistically significant (p=0.830). All patients were evaluated for toxicities. Most patients (75.5%) reported at least one adverse event. Our results through direct comparison of FP+cisplatin with Gem+/-cisplatin as first line treatment did not show any statistical differences in terms of rate of response, PFS and OS. However, our study showed that FP+cisplatin as first line and Gem based second line therapy gave a better OS rate.

Physical demands in elite team handball: comparisons between male and female players.

PubMed

Michalsik, L B; Aagaard, P

2015-09-01

The aim of the present study was to examine potential differences in the physical demands imposed on male vs. female adult elite team handball players during match-play. Male and female elite team handball players were monitored over a six and five season time span, respectively. Each player was evaluated during match-play by use of video recording and subsequent computerized locomotive and technical match analysis. Furthermore, physiological measurements during match-play, physical testing and anthropometric measurements were performed. Female players (FP, N.=82) covered a longer mean total distance per match (4693±333 m, group means±SD) compared to male players (MP, N.=83, 3945±538 m) when playing full time (P<0.01). FP exercised at a greater relative workload (79.4% of VO2-max) than MP (70.9% of VO2-max, P<0.05), but performed less high-intense running per match (2.5% of total distance covered) than MP (7.9%, P<0.01). FP also spent less time standing still (10.8% of total effective playing time) compared to MP (36.9%, P<0.001) and showed fewer activity changes (663.8±99.7) compared to MP (1482.4±312.6, P<0.001). MP received more tackles in total in offence (34.5±21.3) and performed more tackles in total in defence (29.9±12.3) compared to FP (14.6±9.2, 20.7±9.7, P<0.05). Furthermore, MP performed more high-intense technical playing actions per match (36.9±13.1) than FP (28.3±11.0, P<0.05). The mean body height and body mass differed between MP (189.6±5.8 cm, 91.7±7.5 kg) and FP (175.4±6.1 cm, 69.5±6.5 kg, P<0.001). Substantial gender-specific differences in the physical demands in elite team handball were observed, with MP performing more high-intense, strength-related playing actions and high-intensity running than FP. Conversely, FP covered a greater total distance and demonstrated a higher relative workload than MP. The physical training of male and female elite team handball players should be designed to reflect these contrasting needs.

Evolution of China's family planning policy and fertility transition.

PubMed

Lin, F

1998-06-01

This article points out the important role of family planning (FP) in controlling population growth in China. The impact of development on fertility decline is much slower. China's current FP policy promotes deferred marriage and deferred childbearing and fewer, but healthier, births. The policy promotes one child per couple. Rural couples in certain circumstances, such as if the first birth is a girl, are allowed to have a second child that is properly spaced. FP should be promoted in ethnic inhabited areas. Under this policy, fertility declined from 2.59 to 2 children/woman during the period 1987-92. In more developed areas, fertility has declined below replacement level to 1.6. FP was first promoted in the National Program for Agricultural Development in the 1950s. Birth control was promoted in densely populated areas without high minority concentrations. Fertility hovered around 6.1 during 1950-57. The Cultural Revolution halted fertility decline. The 1974 FP policy emphasized deferred marriage and deferred childbearing, and spaced (by 4-5 years) but fewer births. Fertility declined from 4.2 to 2.3 during 1974-80, in response to the government directive. Rural population declined from 4.6 to 2.5, and urban population declined from 2.0 to 1.15. The one-child policy was promoted in 1980 and became official state policy. FP became an obligation to the state. Rural areas were less compliant with the one-child policy, which led to the 1984 allowances for a second child.

Ecotoxicological effects of the insecticide fipronil in Brazilian native stingless bees Melipona scutellaris (Apidae: Meliponini).

PubMed

de Morais, Cássio Resende; Travençolo, Bruno Augusto Nassif; Carvalho, Stephan Malfitano; Beletti, Marcelo Emílio; Vieira Santos, Vanessa Santana; Campos, Carlos Fernando; de Campos Júnior, Edimar Olegário; Pereira, Boscolli Barbosa; Carvalho Naves, Maria Paula; de Rezende, Alexandre Azenha Alves; Spanó, Mário Antônio; Vieira, Carlos Ueira; Bonetti, Ana Maria

2018-09-01

Melipona scutellaris Latreille, 1811 (Hymenoptera, Apidae) is a pollinator of various native and cultivated plants. Because of the expansion of agriculture and the need to ensure pest control, the use of insecticides such as fipronil (FP) has increased. This study aimed to evaluate the effects of sublethal doses of FP insecticide on M. scutellaris at different time intervals (6, 12, and 24 h) after exposure, via individually analyzed behavioral biomarkers (locomotor activity, behavioral change) as well as the effect of FP on different brain structures of bees (mushroom bodies, antennal cells, and optic cells), using sub-individual cell biomarkers (heterochromatin dispersion, total nuclear and heterochromatic volume). Forager bees were collected when they were returning to the nest and were exposed to three different concentrations of FP (0.40, 0.040, and 0.0040 ng a.i/bee) by topical application. The results revealed a reduction in the mean velocity, lethargy, motor difficulty, paralysis, and hyperexcitation in all groups of bees treated with FP. A modification of the heterochromatic dispersion pattern and changes in the total volume of the nucleus and heterochromatin were also observed in the mushroom bodies (6, 12, and 24 h of exposure) and antennal lobes (6 and 12 h) of bees exposed to 0.0040 ng a.i/bee (LD 50/100 ). FP is toxic to M. scutellaris and impairs the essential functions required for the foraging activity. Copyright © 2018 Elsevier Ltd. All rights reserved.

Accelerators for society: succession of European infrastructural projects: CARE, EuCARD, TIARA, EuCARD2

NASA Astrophysics Data System (ADS)

Romaniuk, Ryszard S.

2013-10-01

Accelerator science and technology is one of a key enablers of the developments in the particle physic, photon physics and also applications in medicine and industry. The paper presents a digest of the research results in the domain of accelerator science and technology in Europe, shown during the realization of CARE (Coordinated Accelerator R&D), EuCARD (European Coordination of Accelerator R&D) and during the national annual review meeting of the TIARA - Test Infrastructure of European Research Area in Accelerator R&D. The European projects on accelerator technology started in 2003 with CARE. TIARA is an European Collaboration of Accelerator Technology, which by running research projects, technical, networks and infrastructural has a duty to integrate the research and technical communities and infrastructures in the global scale of Europe. The Collaboration gathers all research centers with large accelerator infrastructures. Other ones, like universities, are affiliated as associate members. TIARA-PP (preparatory phase) is an European infrastructural project run by this Consortium and realized inside EU-FP7. The paper presents a general overview of CARE, EuCARD and especially TIARA activities, with an introduction containing a portrait of contemporary accelerator technology and a digest of its applications in modern society. CARE, EuCARD and TIARA activities integrated the European accelerator community in a very effective way. These projects are expected very much to be continued.

ASTRONET: Towards a Strategic Plan for European Astronomy

NASA Astrophysics Data System (ADS)

Gallego, J.; Torra, J.; Barcons, X.; Mas-Hesse, M.

ASTRONET is an ERA-Net financed by the European Commission FP6 under the initiative Integrating and Strengthening the European Research Area (ERA). ASTRONET was created by a group of European funding agencies in order to establish a comprehensive long-term planning for the development of European astronomy. The objective of this effort is to consolidate and reinforce the world-leading position that European astronomy has attained at the beginning of this twenty-first century. The Ministerio de Ciencia e Innovación is the Spanish representative.

A pilot study of S-1 plus cisplatin versus 5-fluorouracil plus cisplatin for postoperative chemotherapy in histological stage IIIB-IV (M0) gastric cancer.

PubMed

Lee, Sung Sook; Jeung, Hei-Cheul; Chung, Hyun Cheol; Noh, Sung Hoon; Hyung, Woo Jin; Ahn, Ji Yeong; Rha, Sun Young

2012-02-01

Although its efficacy is unproven, 5-fluorouracil plus cisplatin (FP) is used to prevent postoperative relapse in gastric cancer. We investigated the safety and feasibility of S-1 plus cisplatin (SP) vs. FP for stage IIIB-IV (M0) gastric cancer. Following curative resection, 41 stage IIIB-IV (M0) gastric cancer patients were assigned to SP (eight 14-day cycles of S-1 [40 mg/m(2) twice daily] plus cisplatin [60 mg/m(2) day 1] administered every 3 weeks) or FP (six 3-day cycles of FU [1 g/m(2) per day] plus cisplatin [80 mg/m(2) day 1] every 4 weeks). Doses were reduced based on predefined criteria. Patient characteristics were balanced between the two arms. In total, 124 cycles of SP (N = 20, median = 7, range 1-8) and 113 cycles of FP (N = 21, median 6, range 1-6) were administered. The median relative dose intensity per patient was 75% (49.99-100%) for S-1, 100% (75-100%) for cisplatin in SP, and 100% (64-100%) for 5-FU, 100% (60-100%) for cisplatin in FP. The relative dose intensity of FP was stable, while that of SP decreased during treatment. After median follow-up of 7.9 months (3.8-14.55), the median RFS was not reached. Relapse occurred in two (10%) patients on SP and five (23.8%) in the FP arm (P = 0.24). The incidence of grade 3-4 granulocytopenia was 36.8% with SP and 14.3% with FP. Grade 3-4 non-hematologic toxicities included fatigue (5.2% with SP vs. 4.8% with FP), vomiting (10.5% with SP vs. 0% with FP), and infection (5.2% with SP vs. 0% FP). S-1 plus cisplatin was feasible and tolerable as adjuvant treatment for stage IIIB-IV (M0) gastric cancer. However, because of decreased relative dose intensity during treatment, further study is warranted to determine optimal dosage and combination.

After the demographic transition: policy responses to low fertility in four Asian countries.

PubMed

Greenspan, A

1994-09-01

In the low fertility countries of South Korea, Taiwan, Singapore, and Thailand, policy-makers are concerned about the consequences of low growth. In South Korea, a family planning (FP) program was instituted in the early 1960s, and fertility declined to 1.6 by 1987. Rural fertility is still higher at 1.96, and abortion rates are high. 32.2% of fertility reduction is accomplished through abortion. South Korean population will not stabilize until 2021, at 50.6 million people. The elderly are expected to increase and strain housing, energy, and land resources. Government support for FP is being reduced, while private sector services are being enhanced. Government sterilization programs have been reduced significantly, and revisions in the Medical Insurance Law will cover part of contraceptive cost. Integrated services are being established. Many argue for an emphasis on birth spacing, child and family development, sex education, and care of the elderly. In Taiwan, replacement level fertility was reached in 1983. Policy in 1992 recommended increasing fertility from 1.6 to 2.1. The aim was to stabilize population without pronatalist interventions. Regardless of policy decisions, population growth will continue over the next 40 years, and the extent of aging will increase. In Singapore since the 1960s, the national government focused on encouraging small families through fertility incentives, mass media campaigns, and easy access to FP services. Fertility declined to 1.4 in 1988. Since 1983, government has established a variety of pronatalist incentives. In 1989, fertility increased to 1.8. The pronatalist shift is viewed as not likely to succeed in dealing with the concern for an adequate work force to support the elderly and economic development. In Thailand, fertility declined the fastest to 2.4 in 1993. The key factors were rapid economic and social development, a supportive cultural setting, strong demand for fertility control, and a successful FP program. The goal is to reduce fertility to 1.2 by 1996. Replacement level may be reached in 2000 or 2005. Future trends are not clear.

Minimal domain of bacterial phytochrome required for chromophore binding and fluorescence

NASA Astrophysics Data System (ADS)

Rumyantsev, Konstantin A.; Shcherbakova, Daria M.; Zakharova, Natalia I.; Emelyanov, Alexander V.; Turoverov, Konstantin K.; Verkhusha, Vladislav V.

2015-12-01

Fluorescent proteins (FP) are used to study various biological processes. Recently, a series of near-infrared (NIR) FPs based on bacterial phytochromes was developed. Finding ways to improve NIR FPs is becoming progressively important. By applying rational design and molecular evolution we have engineered R. palustris bacterial phytochrome into a single-domain NIR FP of 19.6 kDa, termed GAF-FP, which is 2-fold and 1.4-fold smaller than bacterial phytochrome-based NIR FPs and GFP-like proteins, respectively. Engineering of GAF-FP involved a substitution of 15% of its amino acids and a deletion of the knot structure. GAF-FP covalently binds two tetrapyrrole chromophores, biliverdin (BV) and phycocyanobilin (PCB). With the BV chromophore GAF-FP absorbs at 635 nm and fluoresces at 670 nm. With the PCB chromophore GAF-FP becomes blue-shifted and absorbs at 625 nm and fluoresces at 657 nm. The GAF-FP structure has a high tolerance to small peptide insertions. The small size of GAF-FP and its additional absorbance band in the violet range has allowed for designing a chimeric protein with Renilla luciferase. The chimera exhibits efficient non-radiative energy transfer from luciferase to GAF-FP, resulting in NIR bioluminescence. This study opens the way for engineering of small NIR FPs and NIR luciferases from bacterial phytochromes.

Standard Specifications for Construction of Roads and Bridges on Federal Highway Projects

DOT National Transportation Integrated Search

1996-01-01

These standard specifications were issued primarily for constructing roads and bridges on Federal Highway projects under the direct administration of the Federal Highway Administration. These specifications are cited as "FP-96" indicating Standard Sp...

The role of family planning in achieving safe pregnancy for serodiscordant couples: commentary from the United States government's interagency task force on family planning and HIV service integration.

PubMed

Mason, Jennifer; Medley, Amy; Yeiser, Sarah; Nightingale, Vienna R; Mani, Nithya; Sripipatana, Tabitha; Abutu, Andrew; Johnston, Beverly; Watts, D Heather

2017-03-08

People living with HIV (PLHIV) have the right to exercise voluntary choices about their health, including their reproductive health. This commentary discusses the integral role that family planning (FP) plays in helping PLHIV, including those in serodiscordant relationships, achieve conception safely. The United States (US) President's Emergency Plan for AIDS Relief (PEPFAR) is committed to meeting the reproductive health needs of PLHIV by improving their access to voluntary FP counselling and services, including prevention of unintended pregnancy and counselling for safer conception. Inclusion of preconception care and counselling (PCC) as part of routine HIV services is critical to preventing unintended pregnancies and perinatal infections among PLHIV. PLHIV not desiring a current pregnancy should be provided with information and counselling on all available FP methods and then either given the method onsite or through a facilitated referral process. PLHIV, who desire children should be offered risk reduction counselling, support for HIV status disclosure and partner testing, information on safer conception options to reduce the risk of HIV transmission to the partner and the importance of adhering to antiretroviral treatment during pregnancy and breastfeeding to reduce the risk of vertical transmission to the infant. Integration of PCC, HIV and FP services at the same location is recommended to improve access to these services for PLHIV. Other considerations to be addressed include the social and structural context, the health system capacity to offer these services, and stigma and discrimination of providers. Evaluation of innovative service delivery models for delivering PCC services is needed, including provision in community-based settings. The US Government will continue to partner with local organizations, Ministries of Health, the private sector, civil society, multilateral and bilateral donors, and other key stakeholders to strengthen both the policy and programme environment to ensure that all PLHIV and serodiscordant couples have access to FP services, including prevention of unintended pregnancy and safer conception counselling.

Characterisation of LSO:Tb scintillator films for high resolution X-ray imaging applications

NASA Astrophysics Data System (ADS)

Cecilia, A.; Rack, A.; Douissard, P.-A.; Martin, T.; Dos Santos Rolo, T.; Vagovič, P.; Pelliccia, D.; Couchaud, M.; Dupré, K.; Baumbach, T.

2011-05-01

Within the framework of an FP6 project (SCINTAX)1The Project SCINTAX is funded by the European Community (STRP 033 427), . we developed a new thin film single crystal scintillator for high resolution X-ray imaging based on a layer of modified LSO (Lu2SiO5) grown by liquid phase epitaxy (LPE) on a dedicated substrate. In this work we present the characterisation of the scintillating LSO films in terms of optical and scintillation properties as well as spatial resolution performances. The obtained results are discussed and compared with the performances of the thin scintillating films commonly used in synchrotron-based micro-imaging applications.

Quantity of flowback and produced waters from unconventional oil and gas exploration.

PubMed

Kondash, Andrew J; Albright, Elizabeth; Vengosh, Avner

2017-01-01

The management and disposal of flowback and produced waters (FP water) is one of the greatest challenges associated with unconventional oil and gas development. The development and production of unconventional natural gas and oil is projected to increase in the coming years, and a better understanding of the volume and quality of FP water is crucial for the safe management of the associated wastewater. We analyzed production data using multiple statistical methods to estimate the total FP water generated per well from six of the major unconventional oil and gas formations in the United States. The estimated median volume ranges from 1.7 to 14.3millionL (0.5 to 3.8milliongal) of FP per well over the first 5-10years of production. Using temporal volume production and water quality data, we show a rapid increase of the salinity associated with a decrease of FP production rates during the first months of unconventional oil and gas production. Based on mass-balance calculations, we estimate that only 4-8% of FP water is composed of returned hydraulic fracturing fluids, while the remaining 92-96% of FP water is derived from naturally occurring formation brines that is extracted together with oil and gas. The salinity and chemical composition of the formation brines are therefore the main limiting factors for beneficial reuse of unconventional oil and gas wastewater. Copyright © 2016 Elsevier B.V. All rights reserved.

An analysis of pre-service family planning teaching in clinical and nursing education in Tanzania.

PubMed

Muganyizi, Projestine S; Ishengoma, Joyce; Kanama, Joseph; Kikumbih, Nassoro; Mwanga, Feddy; Killian, Richard; McGinn, Erin

2014-07-12

Promoting family planning (FP) is a key strategy for health, economic and population growth. Sub-Saharan Africa, with one of the lowest contraceptive prevalence and highest fertility rates globally, contributes half of the global maternal deaths. Improving the quality of FP services, including enhancing pre-service FP teaching, has the potential to improve contraceptive prevalence. In efforts to improve the quality of FP services in Tanzania, including provider skills, this study sought to identify gaps in pre-service FP teaching and suggest opportunities for strengthening the training. Data were collected from all medical schools and a representative sample of pre-service nursing, Assistant Medical Officer (AMO), Clinical Officer (CO) and assistant CO schools in mainland Tanzania. Teachers responsible for FP teaching at the schools were interviewed using a semi-structured questionnaire. Observations on availability of teaching resources and other evidence of FP teaching and evaluation were documented. Relevant approved teaching documents were assessed for their suitability as competency-based FP teaching tools against predefined criteria. Quantitative data were analyzed using EPI Info 6 and qualitative data were manually analyzed using content analysis. A total of 35 pre-service schools were evaluated for FP teaching including 30 technical education and five degree offering schools. Of the assessed 11 pre-service curricula, only one met the criteria for suitability of FP teaching. FP teaching was typically theoretical with only 22.9% of all the schools having systems in place to produce graduates who could skillfully provide FP methods. Across schools, the target skills were the same level of competence and skewed toward short acting methods of contraception. Only 23.3% (n = 7) of schools had skills laboratories, 76% (n = 22) were either physically connected or linked to FP clinics. None of the degree providing schools practiced FP at its own teaching hospital. Teachers were concerned with poor practical exposure and lack of teaching material. Pre-service FP teaching in Tanzania is theoretical, poorly guided, and skewed toward short acting methods; a majority of the schools are unable to produce competent FP service providers. Pre-service FP training should be strengthened with more focus on practical skills.

Investigating the potential role of persistent organic pollutants in Hawaiian green sea turtle fibropapillomatosis

USGS Publications Warehouse

Keller, Jennifer M.; Balazs, George H.; Nilsen, Frances; Rice, Marc; Work, Thierry M.; Jensen, Brenda A.

2014-01-01

It has been hypothesized for decades that environmental pollutants may contribute to green sea turtle fibropapillomatosis (FP), possibly through immunosuppression leading to greater susceptibility to the herpesvirus, the putative causative agent of this tumor-forming disease. To address this question, we measured concentrations of 164 persistent organic pollutants (POPs) and halogenated phenols in 53 Hawaiian green turtle (Chelonia mydas) plasma samples archived by the Biological and Environmental Monitoring and Archival of Sea Turtle Tissues (BEMAST) project at the National Institute of Standards and Technology Marine Environmental Specimen Bank. Four groups of turtles were examined: free-ranging turtles from Kiholo Bay (0% FP, Hawaii), Kailua Bay (low FP, 8%, Oahu), and Kapoho Bay (moderate FP, 38%, Hawaii) and severely tumored stranded turtles that required euthanasia (high FP, 100%, Main Hawaiian Islands). Four classes of POPs and seven halogenated phenols were detected in at least one of the turtles, and concentrations were low (often <200 pg/g wet mass). The presence of halogenated phenols in sea turtles is a novel discovery; their concentrations were higher than most man-made POPs, suggesting that the source of most of these compounds was likely natural (produced by the algal turtle diet) rather than metabolites of man-made POPs. None of the compounds measured increased in concentration with increasing prevalence of FP across the four groups of turtles, suggesting that these 164 compounds are not likely primary triggers for the onset of FP. However, the stranded, severely tumored, emaciated turtle group (n = 14) had the highest concentrations of POPs, which might suggest that mobilization of contaminants with lipids into the blood during late-stage weight loss could contribute to the progression of the disease. Taken together, these data suggest that POPs are not a major cofactor in causing the onset of FP.

Investigating the potential role of persistent organic pollutants in Hawaiian green sea turtle fibropapillomatosis.

PubMed

Keller, Jennifer M; Balazs, George H; Nilsen, Frances; Rice, Marc; Work, Thierry M; Jensen, Brenda A

2014-07-15

It has been hypothesized for decades that environmental pollutants may contribute to green sea turtle fibropapillomatosis (FP), possibly through immunosuppression leading to greater susceptibility to the herpesvirus, the putative causative agent of this tumor-forming disease. To address this question, we measured concentrations of 164 persistent organic pollutants (POPs) and halogenated phenols in 53 Hawaiian green turtle (Chelonia mydas) plasma samples archived by the Biological and Environmental Monitoring and Archival of Sea Turtle Tissues (BEMAST) project at the National Institute of Standards and Technology Marine Environmental Specimen Bank. Four groups of turtles were examined: free-ranging turtles from Kiholo Bay (0% FP, Hawaii), Kailua Bay (low FP, 8%, Oahu), and Kapoho Bay (moderate FP, 38%, Hawaii) and severely tumored stranded turtles that required euthanasia (high FP, 100%, Main Hawaiian Islands). Four classes of POPs and seven halogenated phenols were detected in at least one of the turtles, and concentrations were low (often <200 pg/g wet mass). The presence of halogenated phenols in sea turtles is a novel discovery; their concentrations were higher than most man-made POPs, suggesting that the source of most of these compounds was likely natural (produced by the algal turtle diet) rather than metabolites of man-made POPs. None of the compounds measured increased in concentration with increasing prevalence of FP across the four groups of turtles, suggesting that these 164 compounds are not likely primary triggers for the onset of FP. However, the stranded, severely tumored, emaciated turtle group (n=14) had the highest concentrations of POPs, which might suggest that mobilization of contaminants with lipids into the blood during late-stage weight loss could contribute to the progression of the disease. Taken together, these data suggest that POPs are not a major cofactor in causing the onset of FP.

Use of finger-prick dried blood spots (fpDBS) and capillary electrophoresis for carbohydrate deficient transferrin (CDT) screening in forensic toxicology.

PubMed

Bertaso, Anna; Sorio, Daniela; Vandoros, Anthula; De Palo, Elio F; Bortolotti, Federica; Tagliaro, Franco

2016-10-01

Continued progress in chronic alcohol abuse investigation requires the development of less invasive procedures for screening purposes. The application of finger-prick and related dried blood spots (fpDBS) for carbohydrate deficient transferrin (CDT) detection appears suitable for this aim. Therefore, the goal of this project was to develop a screening method for CDT using fpDBS with CZE analysis. Blood samples prepared by finger-prick were placed on DBS cards and left to air dry; each dried fpDBS disc was shredded into small pieces and suspended in acid solution (60 μL of HCl 120 mmol/L). After centrifugation (10 min at 1500 × g), the collected sample was adjusted to pH 3.5. After an overnight incubation, the pH was neutralised and an iron rich solution was added. After 1 h, CZE analysis was carried out. A group of 47 individuals was studied. Parallel serum samples were collected from each investigated subject and the %CDT for each sample was measured using HPLC and CZE techniques. The fpDBS transferrin sialo isoform electropherograms were similar to those obtained with serum. Moreover, fpDBS CZE CDT percentage levels demonstrated significant statistical correlation with those obtained from serum for both HPLC and CZE %CDT (p < 0.01; r 2 = 0.8913 and 0.8976, respectively), with %CDT from 0.8 to 13.7% for fpDBS and from 0.7 to 12.7% for serum. The newly developed fpDBS procedure for CDT analysis provides a simple and inexpensive tool for use in population screening. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Are family physicians good for you? Endogenous doctor supply and individual health.

PubMed

Gravelle, Hugh; Morris, Stephen; Sutton, Matt

2008-08-01

To investigate the impact of family physician (FP) supply on individual health, adjusting for factors that affect both health and FPs' choice of location. A total of 49,541 individuals in 351 English local authorities (LAs). Data on individual health and personal characteristics from three rounds (1998, 1999, and 2000) of the Health Survey for England were linked to LA data on FP supply. Three methods for analyzing self-reported health were used. FP supply, instrumented by house prices and by age-weighted capitation payments for patients on FP lists, was included in individual-level health regressions along with individual and LA covariates. When no instruments are used FPs have a positive but statistically insignificant effect on health. When FP supply is instrumented by age-related capitation it has markedly larger and statistically significant effects. A 10 percent increase in FP supply increases the probability of reporting very good health by 6 percent. After allowing for endogeneity, an increase in FP supply has a significant positive effect on self-reported individual health.

Modulation of JB6 Mouse Epidermal Cell Transformation Response by the Prostaglandin F2 Alpha Receptor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, Thomas J.; Markillie, Lye MENG.; Chrisler, William B.

2002-12-01

Prostaglandin F2a (PGF2a) has been associated with the modulation of clonal selection processes in the mouse skin model of carcinogenesis. We have investigated whether JB6 mouse epidermal cells express a functional PGF2a receptor (FP) coupled to the regulation of anchorage-dependent and -independent growth. Treatment of JB6 cells with a FP receptor ligand (fluprostenol) potently (pM-nM) increased anchorage-dependent and -independent growth, as determined by a battery of in vitro assays. Treatment of JB6 cells with PGF2a and fluprostenol increased inositol phospholipid accumulation and extracellular signal regulated kinase (ERK) activity, consistent with FP receptor-related signaling. FP receptor mRNA was detected by reversemore » transcription-polymerase chain reaction and a radiolabel binding assay determined the average specific [3H]PGF2a binding to be 8.25 + 0.95 fmol/mg protein. Treatment of cells with fluprostenol as a single exposure resulted in a significant increase in anchorage-dependent and -independent growth in media containing low (0.1-0.5%), but not high (5%) concentrations of fetal bovine serum (FBS). In contrast, treatment of cells with fluprostenol at two day intervals resulted in a more robust growth response under anchorage-dependent conditions only in media containing low FBS concentrations; and under anchorage-independent conditions only in media containing high FBS concentrations. ERK activation and colony size were increased by cotreatment of JB6 cells with EGF and fluprostenol to a greater extent than either treatment alone, while the cotreatment effect on colony number appeared to be simply additive. In summary, FBS concentration and signal oscillation exert pronounced effects on the biological response to a FP receptor agonist. The data raise the possibility that the FP receptor may independently contribute to clonal selection processes, but may play a more important role as a response modifier.« less

osFP: a web server for predicting the oligomeric states of fluorescent proteins.

PubMed

Simeon, Saw; Shoombuatong, Watshara; Anuwongcharoen, Nuttapat; Preeyanon, Likit; Prachayasittikul, Virapong; Wikberg, Jarl E S; Nantasenamat, Chanin

2016-01-01

Currently, monomeric fluorescent proteins (FP) are ideal markers for protein tagging. The prediction of oligomeric states is helpful for enhancing live biomedical imaging. Computational prediction of FP oligomeric states can accelerate the effort of protein engineering efforts of creating monomeric FPs. To the best of our knowledge, this study represents the first computational model for predicting and analyzing FP oligomerization directly from the amino acid sequence. After data curation, an exhaustive data set consisting of 397 non-redundant FP oligomeric states was compiled from the literature. Results from benchmarking of the protein descriptors revealed that the model built with amino acid composition descriptors was the top performing model with accuracy, sensitivity and specificity in excess of 80% and MCC greater than 0.6 for all three data subsets (e.g. training, tenfold cross-validation and external sets). The model provided insights on the important residues governing the oligomerization of FP. To maximize the benefit of the generated predictive model, it was implemented as a web server under the R programming environment. osFP affords a user-friendly interface that can be used to predict the oligomeric state of FP using the protein sequence. The advantage of osFP is that it is platform-independent meaning that it can be accessed via a web browser on any operating system and device. osFP is freely accessible at http://codes.bio/osfp/ while the source code and data set is provided on GitHub at https://github.com/chaninn/osFP/.Graphical Abstract.

New development of China's population programme.

PubMed

Peng, P

1998-06-01

This article presents excerpts of a speech presented by the State Family Planning Commissioner of China at the UNFPA headquarters. Madame Peng Peiyun indicated that China has adopted some new decision-making processes as a follow-up to the 1994 ICPD Plan of Action. President Jiang Zemin stated that sustainable development must be achieved as part of the movement toward modernization. China places great importance on balancing population growth, social production, economic development, resources, and the environment. In 1995, the State Family Planning Commission changed its guidelines and approaches by integrating family planning (FP) within socioeconomic development and shifting to an interest oriented program integrated with social restraints and integrating FP publicity and education with comprehensive services and modern management. The FP program should meet the needs for reproductive health and contraception and be integrated within poverty alleviation and economic development schemes in rural areas. The aim is to build happy and more civil-minded farming families. Attention should be directed to the interests of farmers and the physical and psychological health of women. Programs should be voluntary. Many poverty reduction programs operated in the early 1990s. Pilot programs were established in 1995, in 11 selected counties and urban districts. The aim was to improve grassroots efforts to meet clients' needs for quality reproductive health and contraception. In 1994, providers received upgrading of skills. As the most populous country in the world, China needs UNFPA support in stabilizing population growth.

The Philosophy and Approach on Which the PROFILES Project Is Based

ERIC Educational Resources Information Center

Holbrook, Jack; Rannikmäe, Miia

2014-01-01

This article sets out to describe the PROFILES project, a European Commission FP7 science and society project, addresses problems and issues in science education by guiding teachers to embrace a range of teaching factors, such as a context-based approach, motivational constructivist learning; student centred inquiry teaching; enhancing cognitive…

Lessons we most enjoy learning.

PubMed

Coleman, P L

1993-03-01

In the mid-1970s, the Philippine Commission on Population (POPCOM) began to use entertainment programs for reaching people with messages on population and development issues. 2 major motion pictures contained family planning (FP) messages. Radio dramas, print media, and theater also were used to convey FP messages. The early experiments were continued in the late 1980s through the work of the Philippine Center for Population and Development (PCPD). PCPD, with the assistance of the Johns Hopkins University/Population Communication Services (JHU/PCS) project, embarked on a program which used popular music to encourage young people to become sexually responsible adults. In 1990, the Philippine Non-Governmental Organization Council (PNGOC), the Department of Health (DOH) and JHU/PCS began an effort funded by USAID to form a coalition with the entertainment community for social development causes. DOH, JHU/PCS, and USAID wanted to promote FP and health through the Enter-Educate concept. PNGOC and JHU/PCS contacted over 20 entertainment organizations and held more than 75 conferences, work shops, and meetings which attended by more than 300 people. The movement of Entertainment for Social Change was launched in October 1991 with the creation of the Enter-Educate Foundation, Inc. (EEF). The aims of EEF include rewards, professional approach, and establishment of a network of dedicated entertainment and social development professionals. In 1993, a television comedy series will focus on FP as well as on maternal and child health. Further plans at the local level include: tree planting; discussions on migration; talks about FP; meetings on community population and environment activities; and networking of organizations involved with youth, the environment, and population. JHU/PCS provides technical assistance for the production, monitoring, and evaluation of the project. With these efforts, the EEF is attempting to focus on the country's biggest problems: population and the environment.

Adeno-Associated Virus Transfer of a Gene Encoding SNAP-25 Resistant to Botulinum Toxin A Attenuates Neuromuscular Paralysis Associated with Botulism

DTIC Science & Technology

2008-04-02

Associated with Botulism Arvind Raghunath ,1 Francesc Perez-Branguli,1 Leonard Smith,2 and J. Oliver Dolly1 1International Centre for Neurotherapeutics...NUMBER 6. AUTHOR(S) Raghunath A Branguli FP Smith L Dolly JO 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION...Neurosci., April 2, 2008 • 28(14):3683–3688 Raghunath et al. • Botulism Combated by Gene Transfer of Mutated S25 horns, containing the cell bodies

Fertility preservation in pediatric and adolescent cancer patients in Switzerland: A qualitative cross-sectional survey.

PubMed

Diesch, Tamara; von der Weid, Nicolas Xavier; Szinnai, Gabor; Schaedelin, Sabine; De Geyter, Christian; Rovó, Alicia

2016-10-01

Fertility preservation (FP) is an important topic of discussion in the field of oncology, particularly in pediatric oncology. Despite the awareness of severe impact of infertility on quality of life and different guidelines available in this area, the options in FP are not routinely discussed with the pediatric cancer patients and their parents. To the best of our knowledge, this is the first survey report concerned to FP counseling and procedures in pediatric and adolescent cancer patients in Switzerland. This survey was conducted from June 2014 to October 2014 on the counseling and procedures performed between 2009 and 2013; the questionnaire was completed by one of the professional from hematology/oncology centers in Switzerland. Currently, only four out of nine centers have a program for FP. In 2013, 45/301 (15%) patients received FP counseling and 36/301 (12%) underwent an FP procedure. The most commonly performed procedures from 2009 to 2013 were administration of gonadotropin releasing hormone agonist (3%) and cryopreservation of ovarian tissue in females (3%) and cryopreservation of sperms in males (6%); the most frequently cited reason for the absence of FP counseling was lack of time (55%). Therefore, this survey should help to develop and harmonize practices with respect to FP counseling and procedures in Switzerland, and to establish FP as a standard of care during cancer treatment. Copyright © 2016. Published by Elsevier Ltd.

Power Electronics Design of a Solar Powered In-car Wireless Tag for Asset Tracking and Parking Applications

NASA Astrophysics Data System (ADS)

Zhu, D.; Henaut, J.; Beeby, S. P.

2014-11-01

This paper reports the design and testing of a power conditioning circuit for a solar powered in-car wireless tag for asset tracking and parking application. Existing long range asset tracking is based on the GSM/GPRS network, which requires expensive subscriptions. The EU FP7 project CEWITT aims at developing a credit card sized autonomous wireless tag with GNSS geo-positioning capabilities to ensure the integrity and cost effectiveness for parking applications. It was found in previous research that solar cells are the most suitable energy sources for this application. This study focused on the power electronics design for the wireless tag. A suitable solar cell was chosen for its high power density. Charging circuit, hysteresis control circuit and LDO were designed and integrated to meet the system requirement. Test results showed that charging efficiency of 80 % had been achieved.

Acute hyperammonemic encephalopathy after fluoropyrimidine-based chemotherapy: A case series and review of the literature.

PubMed

Mitani, Seiichiro; Kadowaki, Shigenori; Komori, Azusa; Sugiyama, Keiji; Narita, Yukiya; Taniguchi, Hiroya; Ura, Takashi; Ando, Masashi; Sato, Yozo; Yamaura, Hidekazu; Inaba, Yoshitaka; Ishihara, Makoto; Tanaka, Tsutomu; Tajika, Masahiro; Muro, Kei

2017-06-01

Acute hyperammonemic encephalopathy induced by fluoropyrimidines (FPs) is a rare complication. Its pathophysiology remains unclear, especially given the currently used regimens, including intermediate-doses of 5-fluorouracil (5-FU) or oral FP agents. We aimed to characterize the clinical manifestations in cancer patients who developed hyperammonemic encephalopathy after receiving FP-based chemotherapy.We retrospectively reviewed 1786 patients with gastrointestinal or primary-unknown cancer who received FP-based regimens between 2007 and 2012. Eleven patients (0.6%) developed acute hyperammonemic encephalopathy. The incidence according to the administered anticancer drugs were as follows: 5-FU (8 of 1176, 0.7%), S-1 (1 of 679, 0.1%), capecitabine (2 of 225, 0.9%), and tegafur-uracil (UFT) (0 of 39, 0%). Ten patients (90.9%) had at least 1 aggravating factor, including infection, dehydration, constipation, renal dysfunction, and muscle loss. All the 10 patients met the definition of sarcopenia. Median time to the onset of hyperammonemic encephalopathy in the cycle was 3 days (range: 2-21). Three patients (27.3%) developed encephalopathy during the first cycle of the regimen and the remaining 8 patients during the second or more cycles. Seven patients (63.6%) had received at least 1 other FP-containing regimen before without episodes of encephalopathy.All patients recovered soon after immediate discontinuation of chemotherapy and supportive therapies, such as hydration, infusion of branched-chain amino acids, and oral lactulose intake, with a median time to recovery of 2 days (range: <1-7). Four patients (36.4%) received FP-based regimens after improvement of symptoms; 3 patients were successfully managed with dose reduction, and 1 patient, who had developed encephalopathy due to S-1 monotherapy, received modified FOLFOX-6 therapy without encephalopathy later.FP-associated acute hyperammonemic encephalopathy is extremely rare, but a possible event at any time and even during the administration of oral FP agents. Particular attention is warranted when giving FP-based therapy for patients with aggravating factors, such as sarcopenia. This complication can be properly managed with early detection.

Real-time In vivo Diagnosis of Nasopharyngeal Carcinoma Using Rapid Fiber-Optic Raman Spectroscopy.

PubMed

Lin, Kan; Zheng, Wei; Lim, Chwee Ming; Huang, Zhiwei

2017-01-01

We report the utility of a simultaneous fingerprint (FP) (i.e., 800-1800 cm -1 ) and high-wavenumber (HW) (i.e., 2800-3600 cm -1 ) fiber-optic Raman spectroscopy developed for real-time in vivo diagnosis of nasopharyngeal carcinoma (NPC) at endoscopy. A total of 3731 high-quality in vivo FP/HW Raman spectra (normal=1765; cancer=1966) were acquired in real-time from 204 tissue sites (normal=95; cancer=109) of 95 subjects (normal=57; cancer=38) undergoing endoscopic examination. FP/HW Raman spectra differ significantly between normal and cancerous nasopharyngeal tissues that could be attributed to changes of proteins, lipids, nucleic acids, and the bound water content in NPC. Principal components analysis (PCA) and linear discriminant analysis (LDA) together with leave-one subject-out, cross-validation (LOO-CV) were implemented to develop robust Raman diagnostic models. The simultaneous FP/HW Raman spectroscopy technique together with PCA-LDA and LOO-CV modeling provides a diagnostic accuracy of 93.1% (sensitivity of 93.6%; specificity of 92.6%) for nasopharyngeal cancer identification, which is superior to using either FP (accuracy of 89.2%; sensitivity of 89.9%; specificity of 88.4%) or HW (accuracy of 89.7%; sensitivity of 89.0%; specificity of 90.5%) Raman technique alone. Further receiver operating characteristic (ROC) analysis reconfirms the best performance of the simultaneous FP/HW Raman technique for in vivo diagnosis of NPC. This work demonstrates for the first time that simultaneous FP/HW fiber-optic Raman spectroscopy technique has great promise for enhancing real-time in vivo cancer diagnosis in the nasopharynx during endoscopic examination.

All-optical 1st- and 2nd-order differential equation solvers with large tuning ranges using Fabry-Pérot semiconductor optical amplifiers.

PubMed

Chen, Kaisheng; Hou, Jie; Huang, Zhuyang; Cao, Tong; Zhang, Jihua; Yu, Yuan; Zhang, Xinliang

2015-02-09

We experimentally demonstrate an all-optical temporal computation scheme for solving 1st- and 2nd-order linear ordinary differential equations (ODEs) with tunable constant coefficients by using Fabry-Pérot semiconductor optical amplifiers (FP-SOAs). By changing the injection currents of FP-SOAs, the constant coefficients of the differential equations are practically tuned. A quite large constant coefficient tunable range from 0.0026/ps to 0.085/ps is achieved for the 1st-order differential equation. Moreover, the constant coefficient p of the 2nd-order ODE solver can be continuously tuned from 0.0216/ps to 0.158/ps, correspondingly with the constant coefficient q varying from 0.0000494/ps(2) to 0.006205/ps(2). Additionally, a theoretical model that combining the carrier density rate equation of the semiconductor optical amplifier (SOA) with the transfer function of the Fabry-Pérot (FP) cavity is exploited to analyze the solving processes. For both 1st- and 2nd-order solvers, excellent agreements between the numerical simulations and the experimental results are obtained. The FP-SOAs based all-optical differential-equation solvers can be easily integrated with other optical components based on InP/InGaAsP materials, such as laser, modulator, photodetector and waveguide, which can motivate the realization of the complicated optical computing on a single integrated chip.

An analysis of pre-service family planning teaching in clinical and nursing education in Tanzania

PubMed Central

2014-01-01

Background Promoting family planning (FP) is a key strategy for health, economic and population growth. Sub-Saharan Africa, with one of the lowest contraceptive prevalence and highest fertility rates globally, contributes half of the global maternal deaths. Improving the quality of FP services, including enhancing pre-service FP teaching, has the potential to improve contraceptive prevalence. In efforts to improve the quality of FP services in Tanzania, including provider skills, this study sought to identify gaps in pre-service FP teaching and suggest opportunities for strengthening the training. Methods Data were collected from all medical schools and a representative sample of pre-service nursing, Assistant Medical Officer (AMO), Clinical Officer (CO) and assistant CO schools in mainland Tanzania. Teachers responsible for FP teaching at the schools were interviewed using a semi-structured questionnaire. Observations on availability of teaching resources and other evidence of FP teaching and evaluation were documented. Relevant approved teaching documents were assessed for their suitability as competency-based FP teaching tools against predefined criteria. Quantitative data were analyzed using EPI Info 6 and qualitative data were manually analyzed using content analysis. Results A total of 35 pre-service schools were evaluated for FP teaching including 30 technical education and five degree offering schools. Of the assessed 11 pre-service curricula, only one met the criteria for suitability of FP teaching. FP teaching was typically theoretical with only 22.9% of all the schools having systems in place to produce graduates who could skillfully provide FP methods. Across schools, the target skills were the same level of competence and skewed toward short acting methods of contraception. Only 23.3% (n = 7) of schools had skills laboratories, 76% (n = 22) were either physically connected or linked to FP clinics. None of the degree providing schools practiced FP at its own teaching hospital. Teachers were concerned with poor practical exposure and lack of teaching material. Conclusions Pre-service FP teaching in Tanzania is theoretical, poorly guided, and skewed toward short acting methods; a majority of the schools are unable to produce competent FP service providers. Pre-service FP training should be strengthened with more focus on practical skills. PMID:25016391

Comparison of low-intensity blood flow-restricted training-induced muscular hypertrophy in eumenorrheic women in the follicular phase and luteal phase and age-matched men.

PubMed

Sakamaki, Mikako; Yasuda, Tomohiro; Abe, Takashi

2012-05-01

The purpose of this study was to compare the muscle hypertrophic response in women during both the follicular (FP) and the luteal phase (LP) of their menstrual cycles following short-term, low-intensity resistance training combined with blood flow restriction (BFR). Eight eumenorrheic women and five men, all previously untrained, performed unilateral low-intensity (30% of 1 repetition maximum) dumbbell curl training with BFR once a day for 6 days. The opposite arm served as an untrained control. This 6-day training programme was conducted during both menstrual cycle phases: the early FP and the mid LP. MRI-measured biceps muscle volume (MV) and isometric elbow flexion strength were measured in both arms before and 2 days after the final training bout. Significantly (P<0.05) greater muscle hypertrophy was observed in the LP (5·7%) than in the FP (3·7%). The absolute and relative changes in serum hormone concentrations between the two phases did not correlate (P>0.05) with the percentage change in MV between the LP and FP. There was no change in MV in the control arm for both cycle phases. Following training, isometric strength increased (P<0.01) in the LP, but not in the FP (P = 0.17). Relative strength (strength per unit MV) was similar pre- and post-training in both phases. The percentage changes in MV and strength were similar between the women (average of LP and FP) and men. Our results indicate that muscle hypertrophy and strength gain are higher in the LP than in the FP following 6 days of BFR training, although the sex difference in the training response is non-existent. © 2011 The Authors. Clinical Physiology and Functional Imaging © 2011 Scandinavian Society of Clinical Physiology and Nuclear Medicine.

Estimation of wind regime from combination of RCM and NWP data in the Gulf of Riga (Baltic Sea)

NASA Astrophysics Data System (ADS)

Sile, T.; Sennikovs, J.; Bethers, U.

2012-04-01

Gulf of Riga is a semi-enclosed gulf located in the Eastern part of the Baltic Sea. Reliable wind climate data is crucial for the development of wind energy. The objective of this study is to create high resolution wind parameter datasets for the Gulf of Riga using climate and numerical weather prediction (NWP) models as an alternative to methods that rely on observations with the expectation of benefit from comparing different approaches. The models used for the estimation of the wind regime are an ensemble of Regional Climate Models (RCM, ENSEMBLES, 23 runs are considered) and high resolution NWP data. Future projections provided by RCM are of interest however their spatial resolution is unsatisfactory. We describe a method of spatial refinement of RCM data using NWP data to resolve small scale features. We apply the method of RCM bias correction (Sennikovs and Bethers, 2009) previously used for temperature and precipitation to wind data and use NWP data instead of observations. The refinement function is calculated using contemporary climate (1981- 2010) and later applied to RCM near future (2021 - 2050) projections to produce a dataset with the same resolution as NWP data. This method corrects for RCM biases that were shown to be present in the initial analysis and inter-model statistical analysis was carried out to estimate uncertainty. Using the datasets produced by this method the current and future projections of wind speed and wind energy density are calculated. Acknowledgments: This research is part of the GORWIND (The Gulf of Riga as a Resource for Wind Energy) project (EU34711). The ENSEMBLES data used in this work was funded by the EU FP6 Integrated Project ENSEMBLES (Contract number 505539) whose support is gratefully acknowledged.

Integrated crop management practices for maximizing grain yield of double-season rice crop.

PubMed

Wang, Depeng; Huang, Jianliang; Nie, Lixiao; Wang, Fei; Ling, Xiaoxia; Cui, Kehui; Li, Yong; Peng, Shaobing

2017-01-12

Information on maximum grain yield and its attributes are limited for double-season rice crop grown under the subtropical environment. This study was conducted to examine key characteristics associated with high yielding double-season rice crop through a comparison between an integrated crop management (ICM) and farmers' practice (FP). Field experiments were conducted in the early and late seasons in the subtropical environment of Wuxue County, Hubei Province, China in 2013 and 2014. On average, grain yield in ICM was 13.5% higher than that in FP. A maximum grain yield of 9.40 and 10.53 t ha -1 was achieved under ICM in the early- and late-season rice, respectively. Yield improvement of double-season rice with ICM was achieved with the combined effects of increased plant density and optimized nutrient management. Yield gain of ICM resulted from a combination of increases in sink size due to more panicle number per unit area and biomass production, further supported by the increased leaf area index, leaf area duration, radiation use efficiency, crop growth rate, and total nitrogen uptake compared with FP. Further enhancement in the yield potential of double-season rice should focus on increasing crop growth rate and biomass production through improved and integrated crop management practices.

Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET.

PubMed

Reid, Alicia E; Ding, Yu-Shin; Eckelman, William C; Logan, Jean; Alexoff, David; Shea, Colleen; Xu, Youwen; Fowler, Joanna S

2008-04-01

The only radiotracer available for the selective imaging of muscarinic M2 receptors in vivo is 3-(3-(3-[18F]fluoropropyl)thio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine) ([18F]FP-TZTP). We have prepared and labeled 3-(3-(3-fluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridne (FP-TZTP, 3) and two other TZTP derivatives with 11C at the methylpyridine moiety to explore the potential of using 11C-labeled FP-TZTP for positron emission tomography imaging of M2 receptors and to compare the effect of small structural changes on tracer pharmacokinetics (PK) in brain and peripheral organs. 11C-radiolabeled FP-TZTP, 3-(3-propylthio)-TZTP (6) and 3,3,3-(3-(3-trifluoropropyl)-TZTP (10) were prepared, and log D, plasma protein binding (PPB), affinity constants, time-activity curves (TACs), area under the curve (AUC) for arterial plasma, distribution volumes (DV) and pharmacological blockade in baboons were compared. Values for log D, PPB and affinity constants were similar for 3, 6 and 10. The fraction of parent radiotracer in the plasma was higher and the AUC lower for 10 than for 3 and 6. TACs for brain regions were similar for 3 and 6, which showed PK similar to the 18F tracer, while 10 showed slower uptake and little clearance over 90 min. DVs for 3 and 6 were similar to the 18F tracer but higher for 10. Uptake of the three tracers was significantly reduced by coinjection of unlabeled 3 and 6. Small structural variations on the TZTP structure greatly altered the PK in brain and behavior in blood with little change in the log D, PPB or affinity. The study suggests that 11C-radiolabeled 3 will be a suitable alternative to [18F]FP-TZTP for translational studies in humans.

Exploitation of Leuconostoc mesenteroides strains to improve shelf life, rheological, sensory and functional features of prickly pear (Opuntia ficus-indica L.) fruit puree.

PubMed

Di Cagno, Raffaella; Filannino, Pasquale; Vincentini, Olimpia; Lanera, Alessia; Cavoski, Ivana; Gobbetti, Marco

2016-10-01

Strains of Leuconostoc mesenteroides were identified from raw prickly pear (Opuntia ficus-indica L.). Five autochthonous strains were selected based on the kinetics of growth and acidification on prickly pear fruit juice, and the capacity to synthesize exo-polysaccharides. All selected Leuc. mesenteroides strains showed an in vitro mucilage-degrading capability. A protocol for processing and storage of fermented prickly pear fruit puree (FP) was set up. Unstarted FP and chemically acidified FP were used as the controls. Starters grew and remained viable at elevated cell numbers during 21 days of storage at 4 °C. Contaminating Enterobacteriaceae and yeasts were found only in the controls. Viscosity and serum separation distinguished started FP compared to the controls. Colour parameters, browning index, sensory attributes, antimicrobial activity, vitamin C and betalains levels were positively affected by lactic acid fermentation. Increase of free radical scavenging activity in ethyl acetate soluble extract suggested an effect of selected strains on phenolic profiles. Started FP markedly inhibited the inflammatory status of Caco-2/TC7 cells, and also contributed to maintaining the integrity of tight junctions. Started FP scavenged the reactive oxygen species generated by H2O2 on Caco-2 cells. All selected strain variously affected the immunomodulatory activity towards anti- and pro-inflammatory cytokines. Copyright © 2016 Elsevier Ltd. All rights reserved.

Long-Term Safety of Letrozole and Gonadotropin Stimulation for Fertility Preservation in Women With Breast Cancer

PubMed Central

Kim, Jayeon; Turan, Volkan

2016-01-01

Context and Objective: There has been increased attention to the issue of fertility preservation (FP). We aimed to investigate the long-term safety of FP via controlled ovarian stimulation with letrozole supplementation (COSTLES) prior to breast cancer treatment. Design, Setting, and Participants: This is a prospective, nonrandomized, controlled study conducted between the years 2002 and 2014. A total of 337 women diagnosed with stage 3 or less invasive breast cancer were enrolled during a FP consultation before chemotherapy. Of those, 120 elected to undergo COSTLES for FP prior to chemotherapy (FP group). The remaining 217 patients did not undergo any FP procedure and served as the controls. Main Outcome Measure: The primary end point was cancer recurrence defined as the detection of locoregional tumor (chest wall, regional nodal disease), distant metastases, or contralateral invasive breast cancer. Results: The baseline characteristics at enrollment were similar between the FP and control groups except for the less frequent lymph node involvement (P = .02) in the former. The mean follow-up after diagnosis was 5.0 years in the FP group and 6.9 years in the control group. In the FP group, the hazard ratio for recurrence after ovarian stimulation was 0.77 (95% confidence interval 0.28–2.13), and the survival was not compromised compared with controls (P = .61). Neither BRCA gene mutation status (P = .57) nor undergoing FP before or after breast surgery (P = .44) affected survival outcomes in the FP group. Likewise, none of the tumor characteristics including the estrogen receptor status affected the survival rates after the COSTLES. Conclusion: COSTLES is unlikely to cause a substantially increased recurrence risk in breast cancer during the 5 years after diagnosis. PMID:26751194

The FP7 ULTimateCO2 project: a study of the long term fate of CO2

NASA Astrophysics Data System (ADS)

Audigane, Pascal; Waldmann, Svenja; Pearce, Jonathan; Dimier, Alain; Le Gallo, Yann; Frykman, Peter; Maurand, Nicolas; Gherardi, Fabrizio; Yalamas, Thierry; Cremer, Holger; Spiers, Chris; Nussbaum, Christophe

2014-05-01

The objectives of the European FP7 ULTimateCO2 project are to study specific processes that could influence the long-term fate of geologically stored CO2, mainly: the trapping mechanisms occurring in the storage reservoir, the influence of fluid-rock interactions on mechanical integrity of caprock and well vicinity, and also the modifications induced at the regional scale (brine displacement, fault reactivation, hydrogeology changes...). A comprehensive approach combining laboratory experiments, numerical modeling and natural analogue studies is developed to assess all the processes mentioned above. A collection of data has been generated from natural and industrial (oil industry) analogues on the fluid flow and mechanical properties, structure, and mineralogy of faults and fractures that could affect the long-term storage capacity of underground CO2 storage sites. To address geochemical trapping at reservoir scale, an experimental approach is developed using sandstone core materials in batch reactive mode with CO2 and impurities at reservoir pressure and temperature conditions. Three inter-related lines of laboratory experiments investigate the long-term evolution of the mechanical properties and sealing integrity of fractured and faulted caprocks using Opalinus clay of Mont Terri Gallery (Switzerland), an analogue for caprock well investigated in the past for nuclear waste disposal purpose. To evaluate the interactions between CO2 (and formation fluid) and the well environment (formation, cement, casing) and to assess the consequences of these interactions on the transport properties of well materials, a 1 to 1 scale experiment has been set in the Mont Terri Gallery Opalinus clay to reproduce classical well objects (cemented annulus, casing and cement plug) perforating caprock formations. An extensive program of numerical modeling is also developed to calibrate, to reproduce and to extrapolate the experimental results at longer time scales including uncertainty assessment methods. www.ultimateco2.eu

Use of consumer insight in the new product development process in the meat sector.

PubMed

Grunert, Klaus G; Verbeke, Wim; Kügler, Jens O; Saeed, Faiza; Scholderer, Joachim

2011-11-01

Successful new product development requires input from the market throughout the product development process, from identification of opportunities via screening of ideas, development of concepts, development of physical prototypes and to launch. Drawing on work done in the EU FP6 projects PROSAFEBEEF and Q-PORKCHAINS and a Danish project, all dealing with new product development in the meat sector, it is shown how the use of consumer insight techniques can a) support the identification of market opportunities, b) make sure that technologies applied are acceptable to consumers, c) aid the selection and optimisation of new product concepts and related communication, and d) be used to test product prototypes before final launch. Copyright © 2011 Elsevier Ltd. All rights reserved.

Basic and clinical proteomics from the EU Health Research perspective.

PubMed

Dyląg, Tomasz; Jehenson, Philippe; van de Loo, Jan-Willem; Sanne, Jean-Luc

2010-12-01

The European Union (EU) is one of the main public funders of research in Europe and its major instrument for funding is the Seventh Framework Programme for research and technological development (FP7). The bulk of funding in FP7 goes to collaborative research, with the objective of establishing excellent research projects and networks. Understanding the functions of proteins is essential for the rational development of disease prevention, diagnosis and treatment, therefore the EU has largely invested in proteomics, in particular for technology development, data standardisation and sharing efforts, and the application of proteomics in the clinic. The scientific community, including both academia and industry, is encouraged to apply for FP7 funding so that the EU can even more efficiently support innovative health research and ultimately, bring better healthcare to patients.

Effect of clinical use of nickel-titanium springs.

PubMed

Magno, Amanda Fahning; Monini, André da Costa; Capela, Marisa Veiga; Martins, Lídia Parsekian; Martins, Renato Parsekian

2015-07-01

Our objectives were to determine whether there are changes on the load deflection rate (L/DP) and the average force (FP) of the superelastic pseudoplateau, and whether permanent deformation is changed in nickel-titanium closed-coil springs (CCSs) after 6 months of clinical use. Twenty-two nickel-titanium CCSs (Sentalloy 100 g; Dentsply GAC, York, Pa) were subjected to tensile mechanical testing at 37°C on activations varying from 3.2 to 16.0 mm before and after 6 months of clinical use. A regression line was fitted over the most horizontal area of the unloading part of the stress-strain graph of every CCS, and its slope was used as L/DP. The FP was determined by the midpoint of the longest segment of the curve that could be fit within the regression line with a R(2) of at least 0.999, and permanent deformation was determined graphically by obtaining the strain value when the measured stress reached zero. The data were analyzed by 3 analyses of variance at 2 levels, with 5% of significance. Time and activation significantly influenced the variables tested (P < 0.001). Time increased the L/DP and permanent deformation but decreased the FP. Activation decreased L/DP, FP, and permanent deformation. Significant interactions between time and activation were detected for FP (P = 0.013) and deformation (P < 0.001). After 6 months of active clinical use, the analyzed springs had a significant but small increase in their L/DP; FP dropped up to 88%, and the CCSs deformed up to 1.26 mm. Copyright © 2015 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

Polarized-pixel performance model for DoFP polarimeter

NASA Astrophysics Data System (ADS)

Feng, Bin; Shi, Zelin; Liu, Haizheng; Liu, Li; Zhao, Yaohong; Zhang, Junchao

2018-06-01

A division of a focal plane (DoFP) polarimeter is manufactured by placing a micropolarizer array directly onto the focal plane array (FPA) of a detector. Each element of the DoFP polarimeter is a polarized pixel. This paper proposes a performance model for a polarized pixel. The proposed model characterizes the optical and electronic performance of a polarized pixel by three parameters. They are respectively major polarization responsivity, minor polarization responsivity and polarization orientation. Each parameter corresponds to an intuitive physical feature of a polarized pixel. This paper further extends this model to calibrate polarization images from a DoFP (division of focal plane) polarimeter. This calibration work is evaluated quantitatively by a developed DoFP polarimeter under varying illumination intensity and angle of linear polarization. The experiment proves that our model reduces nonuniformity to 6.79% of uncalibrated DoLP (degree of linear polarization) images, and significantly improves the visual effect of DoLP images.

A BCWD-resistant line of rainbow trout exhibits higher abundance of IgT+ B cells and heavy chain tau transcripts compared to a susceptible line following challenge with Flavobacterium psychrophilum.

PubMed

Zwollo, Patty; Hennessey, Erin; Moore, Catherine; Marancik, David P; Wiens, Gregory D; Epp, Lidia

2017-09-01

Bacterial Cold Water Disease (BCWD) is a common, chronic disease in rainbow trout, and is caused by the gram-negative bacterium Flavobacterium psychrophilum (Fp). Through selective breeding, the National Center for Cool and Cold Water Aquaculture has generated a genetic line that is highly resistant to Fp challenge, designated ARS-Fp-R (or R-line), as well as a susceptible "control" line, ARS-Fp-S (S-line). In previous studies, resistance to Fp had been shown to correlate with naive animal spleen size, and further, naïve R-line trout had been shown to have a lower abundance of IgM + and IgM ++ cells compared to S-line fish. Here we wished to first determine whether the abundance of IgT + and/or IgT ++ cells differed between the two lines in naïve fish, and if so, how these patterns differed after in vivo challenge with Fp. Fp challenge was by intramuscular injection of live Fp and tissue collections were on days 5, 6, and/or 28 post-challenge, in two independent challenge experiments. Flow cytometric and gene expression analyses revealed that naïve R-line fish had a higher abundance of IgT + B cells in their anterior kidney, spleen, and blood, compared to S line fish. Further, that after Fp challenge, this difference was maintained between the two lines. Lastly, abundance of IgT + B cells and expression of secHCtau correlated with lower Fp pathogen loads in challenged fish. In the anterior kidney, IgM + B cell abundance correlated with increased Fp loads. Together, these results suggest that IgT + B lineage cells may have a protective function in the immune response to Fp. Copyright © 2017 Elsevier Ltd. All rights reserved.

First results from SAM-FP: Fabry-Perot observations with ground-layer adaptive optics - the structure and kinematics of the core of 30 Doradus

NASA Astrophysics Data System (ADS)

Mendes de Oliveira, C.; Amram, P.; Quint, Bruno C.; Torres-Flores, S.; Barbá, R.; Andrade, D.

2017-08-01

The aim of this paper is to present the first data set obtained with SOAR Adaptive Module-Fabry-Parot (SAM-FP), a Fabry-Perot instrument mounted inside the SOAR telescope Adaptive-Optics Module. This is the only existing imaging Fabry-Perot interferometer using laser-assisted ground-layer adaptive optics. SAM-FP was used to observe the ionized gas, traced by Hα, in the centre of the 30 Doradus starburst (the Tarantula Nebula) in the Large Magellanic Cloud, with high spatial (˜0.6 arcsec, or 0.15 pc) and spectral (R ≃ 11 200) resolution. Radial velocity, velocity dispersion and monochromatic maps were derived. The region displays a mix of narrow, σ ˜ 20 km s-1 profiles and multiple broader profiles with σ ˜ 70-80 km s-1, indicating the complex nature of the nebula kinematics. A comparison with previously obtained VLT/FLAMES spectroscopy demonstrates that the data agree well in the regions of overlap, but the Fabry-Perot data are superior in spatial coverage. A preliminary analysis of the observations finds a new expanding bubble south of R136, with a projected radius of r = 5.6 pc and an expansion velocity of 29 ± 4 km s-1. In addition, the first-time detailed kinematic maps derived here for several complexes and filaments of 30 Doradus allow identification of kinematically independent structures. These data exemplify the power of the combination of a high-order Fabry-Perot with a wide-field imager (3 × 3 arcmin2 GLAO-corrected field of view) for high-resolution spatial and spectral studies. In particular, SAM-FP data cubes are highly advantageous over multifibre or long-slit data sets for nebula structure studies and to search for small-scale bubbles, given their greatly improved spatial coverage. For reference, this paper also presents two appendices with detailed descriptions of the usage of Fabry-Perot devices, including formulae and explanations for understanding Fabry-Perot observations.

Quantitative evaluation of the stretch reflex before and after hydro kinesy therapy in patients affected by spastic paresis.

PubMed

Pagliaro, P; Zamparo, P

1999-04-01

The aim of this study was the quantitative evaluation of the myotatic reflex in a group of 26 patients affected by stationary spastic paresis (6: hemiparesis; 5: paraparesis; 8: tetraparesis; 7: multiple sclerosis) before and after a treatment of hydro-kinesy therapy. The treatment was carried out in an indoor pool containing warm (32 degrees C) sea water and consisted of active and passive motion exercises, coordination exercises and immersion walking. The measured parameters were: (i) the peak input force (FpH) measured by means of an instrumented hammer with which the patellar tendon was hit; and (ii) the peak value of the corresponding reflex force of the quadriceps femoris (FpQ) measured by means of a load cell connected to the subject's ankle. The peak values of the reflex response (FpQ) were found to increase as a function of the intensity of the imposed stimulus and to reach a plateau between 15 and 30 N of FpH. A Student's t test applied to the paired values of FpQ (as measured at plateau conditions) on both the lower limbs, before and after therapy, showed no significant changes due to the treatment in the four groups of subjects. However, if all subjects were grouped regardless the type of illness: 1) the average reflex response of the affected limb (the one characterized before therapy by the higher FpQ values) was found to decrease following the treatment (75.1+/-26.7 N pre therapy and 69.1+/-29.3 N post therapy, p = 0.07, n = 26); and 2) the effect of the treatment was found to be significantly larger (p = 0.04, n = 26) on the affected limb (delta FpQ = 6.07+/-16.5 N) as respect with the contra lateral one (delta FpQ = -0.16+/-12.1 N).

The role of family planning in achieving safe pregnancy for serodiscordant couples: commentary from the United States government’s interagency task force on family planning and HIV service integration

PubMed Central

Mason, Jennifer; Medley, Amy; Yeiser, Sarah; Nightingale, Vienna R.; Mani, Nithya; Sripipatana, Tabitha; Abutu, Andrew; Johnston, Beverly; Watts, D. Heather

2017-01-01

Abstract Introduction: People living with HIV (PLHIV) have the right to exercise voluntary choices about their health, including their reproductive health. This commentary discusses the integral role that family planning (FP) plays in helping PLHIV, including those in serodiscordant relationships, achieve conception safely. The United States (US) President’s Emergency Plan for AIDS Relief (PEPFAR) is committed to meeting the reproductive health needs of PLHIV by improving their access to voluntary FP counselling and services, including prevention of unintended pregnancy and counselling for safer conception. Discussion: Inclusion of preconception care and counselling (PCC) as part of routine HIV services is critical to preventing unintended pregnancies and perinatal infections among PLHIV. PLHIV not desiring a current pregnancy should be provided with information and counselling on all available FP methods and then either given the method onsite or through a facilitated referral process. PLHIV, who desire children should be offered risk reduction counselling, support for HIV status disclosure and partner testing, information on safer conception options to reduce the risk of HIV transmission to the partner and the importance of adhering to antiretroviral treatment during pregnancy and breastfeeding to reduce the risk of vertical transmission to the infant. Integration of PCC, HIV and FP services at the same location is recommended to improve access to these services for PLHIV. Other considerations to be addressed include the social and structural context, the health system capacity to offer these services, and stigma and discrimination of providers. Conclusion: Evaluation of innovative service delivery models for delivering PCC services is needed, including provision in community-based settings. The US Government will continue to partner with local organizations, Ministries of Health, the private sector, civil society, multilateral and bilateral donors, and other key stakeholders to strengthen both the policy and programme environment to ensure that all PLHIV and serodiscordant couples have access to FP services, including prevention of unintended pregnancy and safer conception counselling. PMID:28361500

Role of nutrients and illuminance in predicting the fate of fungal mediated petroleum hydrocarbon degradation and biomass production.

PubMed

Ali Khan, Aqib Hassan; Tanveer, Sundus; Anees, Mariam; Muhammad, Yousaf Shad; Iqbal, Mazhar; Yousaf, Sohail

2016-07-01

Biodegradation and biomass production are affected by numerous environmental factors including pH, oxygen availability and presence of pollutants. The present study, for the first time, elucidated the effects of nutrients and light on mycodegradation of petroleum hydrocarbons in diesel oil. Seven fungal strains (Aspergillus terreus FA3, Aspergillus niger FA5, Aspergillus terreus FA6, Penicillium chrysogenum FP4, Aspergillus terreus FP6, Aspergillus flavus FP10, and Candida sp. FG1) were used for hydrocarbon degradation under static conditions, in four combinations of nutrient media and illuminance for 45 days. Highest degradation was achieved by Aspergillus terreus FA6 and Candida sp. FG1 under both conditions of light and dark, with nutrient deprived HAF (Hydrocarbon adopted fungi) broth. Under HAF/Dark diesel oil degradation by FA6 and FG1 was 87.3% and 84.3% respectively, while under HAF/Light both FA6 and FG1 performed 84.3% biodegradation. The highest biomass was produced by Aspergillus flavus FP10 in PDB (Potato dextrose broth)/Dark (109.3 mg). Fungal degradation of petroleum hydrocarbons was negatively affected by the presence of other simpler-to-degrade carbon sources in the medium. The biomass production was enhanced by improved nutrient availability and diminished by illuminance. Copyright © 2016 Elsevier Ltd. All rights reserved.

Cross-frequency synchronization connects networks of fast and slow oscillations during visual working memory maintenance.

PubMed

Siebenhühner, Felix; Wang, Sheng H; Palva, J Matias; Palva, Satu

2016-09-26

Neuronal activity in sensory and fronto-parietal (FP) areas underlies the representation and attentional control, respectively, of sensory information maintained in visual working memory (VWM). Within these regions, beta/gamma phase-synchronization supports the integration of sensory functions, while synchronization in theta/alpha bands supports the regulation of attentional functions. A key challenge is to understand which mechanisms integrate neuronal processing across these distinct frequencies and thereby the sensory and attentional functions. We investigated whether such integration could be achieved by cross-frequency phase synchrony (CFS). Using concurrent magneto- and electroencephalography, we found that CFS was load-dependently enhanced between theta and alpha-gamma and between alpha and beta-gamma oscillations during VWM maintenance among visual, FP, and dorsal attention (DA) systems. CFS also connected the hubs of within-frequency-synchronized networks and its strength predicted individual VWM capacity. We propose that CFS integrates processing among synchronized neuronal networks from theta to gamma frequencies to link sensory and attentional functions.

A comparison of speech outcomes using radical intravelar veloplasty or furlow palatoplasty for the treatment of velopharyngeal insufficiency associated with occult submucous cleft palate.

PubMed

Afrooz, Paul Nader; MacIsaac, Zoe; Rottgers, Stephen Alex; Ford, Matthew; Grunwaldt, Lorelei J; Kumar, Anand R

2015-02-01

The safety, efficacy, and direct comparison of various surgical treatments for velopharyngeal insufficiency (VPI) associated with occult submucous cleft palate (OSMCP) are poorly characterized. The aim of this study was to report and analyze the safety and efficacy of Furlow palatoplasty (FP) versus radical intravelar veloplasty (IVV) for treatment of VPI associated with OSMCP. A retrospective review of one institution's experience treating VPI associated with OSMCP using IVV (group 1) or FP (group 2) during 24 months was performed. Statistical significance was determined by Wilcoxon matched-pair, Independent-Samples Mann-Whitney U, and analysis of variance (SPSS 20.0.0). In group 1 (IVV), 18 patients were identified from August 2010 to 2011 (12 male and 6 female patients; average age, 5.39 years). Seven patients were syndromic and 11 were nonsyndromic. In group 2 (FP), 17 patients were identified from August 2009 to 2011 (8 male and 9 female patients; average age, 8.37 years). Three patients were syndromic and 14 patients were nonsyndromic. There was statistical significance between the average pretreatment Pittsburgh Weighted Speech Score (PWSS) of the 2 groups (group 1 and 2 averages 19.06 and 11.05, respectively, P=0.002), but there was no statistical significance postoperatively (group 1 and 2 averages 4.50 and 4.69, respectively, P=0.405). One patient from each group required secondary speech surgery. Average operative time was greater for FP (140 minutes; range, 93-177 minutes) compared to IVV (95 minutes; range, 58-135 minutes), P<0.001. Average hospital stay was 3.9 days for IVV (range, 2-9 days) and 3.2 days for FP (range, 2-6 days), with no significant difference (P=0.116). There were no postsurgical wound infections, oral-nasal fistulas, postoperative bleeding complications, or mortalities. Nonsyndromic patients with hypernasal speech are treated effectively and safely with either IVV or FP. Intravelar veloplasty trended toward lower speech scores than FP (76% IVV, 58% FP PWSS absolute reduction). Syndromic patients with OSMCP may be more effectively treated with FP (72% IVV vs 79% FP PWSS absolute reduction). Intravelar veloplasty is associated with shorter operative times. Both techniques are associated with low morbidity, improved speech scores, and low reoperative rates.

Family Planning Practice Among Rural Reproductive-Age Married Women in Myanmar.

PubMed

Jirapongsuwan, Ann; Latt, Kyaw Thu; Siri, Sukhontha; Munsawaengsub, Chokchai

2016-05-01

A cross-sectional study was undertaken to investigate family planning (FP) practices and associated factors among reproductive-age married women. Data were collected by interviewing the 300 married women living in a rural area of Myanmar. The questionnaire had reliability coefficients ranging from .8 to .9. Results indicated that 73.3% of women performed FP, and contraceptive injection was the most common method. Significant associations were found with age 21 to 35 years (adjusted odds ratio [adj OR] = 3.748, 95% CI = 2.179-6.445), adequacy of income (adj OR = 2.520, 95% CI = 1.477-4.290), good attitude toward FP (adj OR = 0.386, 95% CI = 0.228-0.656), good support from health care providers (adj OR = 0.129, 95% CI = 0.054-0.313), good support from family (adj OR = 0.304, 95% CI = 0.163-0.565), good support from friends (adj OR = 0.344, 95% CI = 0.193-0.613), and FP practice. It is recommended that designing FP programs with peers and family involvement could increase the practice of FP among rural Myanmar women. © 2016 APJPH.

CHANGES SDSS: the development of a Spatial Decision Support System for analysing changing hydro-meteorological risk

NASA Astrophysics Data System (ADS)

van Westen, Cees; Bakker, Wim; Zhang, Kaixi; Jäger, Stefan; Assmann, Andre; Kass, Steve; Andrejchenko, Vera; Olyazadeh, Roya; Berlin, Julian; Cristal, Irina

2014-05-01

Within the framework of the EU FP7 Marie Curie Project CHANGES (www.changes-itn.eu) and the EU FP7 Copernicus project INCREO (http://www.increo-fp7.eu) a spatial decision support system is under development with the aim to analyse the effect of risk reduction planning alternatives on reducing the risk now and in the future, and support decision makers in selecting the best alternatives. The Spatial Decision Support System will be composed of a number of integrated components. The Risk Assessment component allows to carry out spatial risk analysis, with different degrees of complexity, ranging from simple exposure (overlay of hazard and assets maps) to quantitative analysis (using different hazard types, temporal scenarios and vulnerability curves) resulting into risk curves. The platform does not include a component to calculate hazard maps, and existing hazard maps are used as input data for the risk component. The second component of the SDSS is a risk reduction planning component, which forms the core of the platform. This component includes the definition of risk reduction alternatives (related to disaster response planning, risk reduction measures and spatial planning) and links back to the risk assessment module to calculate the new level of risk if the measure is implemented, and a cost-benefit (or cost-effectiveness/ Spatial Multi Criteria Evaluation) component to compare the alternatives and make decision on the optimal one. The third component of the SDSS is a temporal scenario component, which allows to define future scenarios in terms of climate change, land use change and population change, and the time periods for which these scenarios will be made. The component doesn't generate these scenarios but uses input maps for the effect of the scenarios on the hazard and assets maps. The last component is a communication and visualization component, which can compare scenarios and alternatives, not only in the form of maps, but also in other forms (risk curves, tables, graphs). The envisaged users of the platform are organizations involved in planning of risk reduction measures, and that have staff capable of visualizing and analysing spatial data at a municipal scale.

QI2S - Quick Image Interpretation System

NASA Astrophysics Data System (ADS)

Naghmouchi, Jamin; Aviely, Peleg; Ginosar, Ran; Ober, Giovanna; Bischoff, Ole; Nadler, Ron; Guiser, David; Citroen, Meira; Freddi, Riccardo; Berekovic, Mladen

2015-09-01

The evolution of the Earth Observation mission will be driven by many factors, and the deveploment of new processing paradigms to facilitate data downlink, handling and storage will be a key factor. Next generation EO satellites will generate a great amount of data at a very high data rate, both radar and optical. Real-time onboard processing can be the solution to reduce data downlink and management on ground. Radiometric, geometric, and atmospheric corrections of EO data as well as material/object detection in addition to the well-known needs for image compression and signal processing can be performed directly on board and the aim of QI2S project is to demonstrate this. QI2S, a concept prototype system for novel onboard image processing and image interpretation which has been designed, developed and validated in the framework of an EU FP7 project, targets these needs and makes a significant step towards exceeding current roadmaps of leading space agencies for future payload processors. The QI2S system features multiple chip components of the RC64, a novel rad-hard 64-core signal processing chip, which targets DSP performance of 75 GMACs (16bit), 150 GOPS and 38 single precision GFLOPS while dissipating less than 10 Watts. It integrates advanced DSP cores with a multibank shared memory and a hardware scheduler, also supporting DDR2/3 memory and twelve 3.125 Gbps full duplex high-speed serial links using SpaceFibre and other protocols. The processor is being developed within the European FP7 Framework Program and will be qualified to the highest space standards.

CLIMB - Climate induced changes on the hydrology of mediterranean basins - Reducing uncertainties and quantifying risk

NASA Astrophysics Data System (ADS)

Ludwig, Ralf

2010-05-01

According to future climate projections, Mediterranean countries are at high risk for an even pronounced susceptibility to changes in the hydrological budget and extremes. These changes are expected to have severe direct impacts on the management of water resources. Threats include severe droughts and extreme flooding, salinization of coastal aquifers, degradation of fertile soils and desertification due to poor and unsustainable water management practices. It can be foreseen that, unless appropriate adaptation measures are undertaken, the changes in the hydrologic cycle will give rise to an increasing potential for tension and conflict among the political and economic actors in this vulnerable region. The presented project initiative CLIMB, funded under EC's 7th Framework Program (FP7-ENV-2009-1), has started in January 2010. In its 4-year design, it shall analyze ongoing and future climate induced changes in hydrological budgets and extremes across the Mediterranean and neighboring regions. This is undertaken in study sites located in Sardinia, Northern Italy, Southern France, Tunisia, Egypt and the Palestinian-administered area Gaza. The work plan is targeted to selected river or aquifer catchments, where the consortium will employ a combination of novel field monitoring and remote sensing concepts, data assimilation, integrated hydrologic (and biophysical) modeling and socioeconomic factor analyses to reduce existing uncertainties in climate change impact analysis. Advanced climate scenario analysis will be employed and available ensembles of regional climate model simulations will be downscaling. This process will provide the drivers for an ensemble of hydro(-geo)logical models with different degrees of complexity in terms of process description and level of integration. The results of hydrological modeling and socio-economic factor analysis will enable the development of a GIS-based Vulnerability and Risk Assessment Tool. This tool will serve as a platform for the dissemination of project results, including communication with and planning for local and regional stakeholders. An im¬portant output of the research in the individual study sites will be the development of a set of recommendations for an improved monitoring and modeling strategy for climate change impact assessment. CLIMB is forming a cluster of independent projects with WASSERMed from the Environment and CLICO from Social Sciences and Humanities Call of FP7 in 2009. The intention of this clustering is to foster scientific synergy and cooperation between the partner projects to achieve improvements in policy outreach on different spatial scales.

An AFDX Network for Spacecraft Data Handling

NASA Astrophysics Data System (ADS)

Deredempt, Marie-Helene; Kollias, Vangelis; Sun, Zhili; Canamares, Ernest; Ricco, Philippe

2014-08-01

In aeronautical domain, ARINC-664 Part 7 specification (AFDX) [4] provides the enabling technology for interfacing equipment in Integrated Modular Avionics (IMA) architectures. The complementary part of AFDX for a complete interoperability - Time and Space Partitioning (ARINC 653) concepts [1]- was already studied as part of space domain ESA roadmap (i.e. IMA4Space project)Standardized IMA based architecture is already considered in aeronautical domain as more flexible, reliable and secure. Integration and validation become simple, using a common set of tools and data base and could be done by part on different means with the same definition (hardware and software test benches, flight control or alarm test benches, simulator and flight test installation).In some area, requirements in terms of data processing are quite similar in space domain and the concept could be applicable to take benefit of the technology itself and of the panel of hardware and software solutions and tools available on the market. The Mission project (Methodology and assessment for the applicability of ARINC-664 (AFDX) in Satellite/Spacecraft on-board communicatION networks), as an FP7 initiative for bringing terrestrial SME research into the space domain started to evaluate the applicability of the standard in space domain.

Section 107 Detailed Project Report. Fort Gaines Channel (Government Cut) at Dauphin Island, Alabama

DTIC Science & Technology

1990-03-01

Engineer District, Mobile AREA &WORK UNIT NUMBERS Plan Dev. Sec., Planning Div., (CESAM-PD-FP)- P. 0. Box 2-288, Mobi,L.3.a6628-OO.....,__ 11I...C’ONTAOLLING OFFICE NAME AND ADDRESS M 2 REPORT DATE US. Army Engineer District, Mobile March 1990 Pian Development Sec., Plan. Div., (CESAM-PD-FP) 13 NUMBER...OF PAGES P- 0. Box 2288, Mobile , AL 36628-0001 162 t4. MONITORING AGENCY NAME & ADORESS(11 different from Controlling Office) 15. SECURITY CLASS. (ol

Effect of specific amino acid substitutions in the putative fusion peptide of structural glycoprotein E2 on Classical Swine Fever Virus replication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fernández-Sainz, I.J.; Largo, E.; Gladue, D.P.

E2, along with E{sup rns} and E1, is an envelope glycoprotein of Classical Swine Fever Virus (CSFV). E2 is involved in several virus functions: cell attachment, host range susceptibility and virulence in natural hosts. Here we evaluate the role of a specific E2 region, {sup 818}CPIGWTGVIEC{sup 828}, containing a putative fusion peptide (FP) sequence. Reverse genetics utilizing a full-length infectious clone of the highly virulent CSFV strain Brescia (BICv) was used to evaluate how individual amino acid substitutions within this region of E2 may affect replication of BICv. A synthetic peptide representing the complete E2 FP amino acid sequence adoptedmore » a β-type extended conformation in membrane mimetics, penetrated into model membranes, and perturbed lipid bilayer integrity in vitro. Similar peptides harboring amino acid substitutions adopted comparable conformations but exhibited different membrane activities. Therefore, a preliminary characterization of the putative FP {sup 818}CPIGWTGVIEC{sup 828} indicates a membrane fusion activity and a critical role in virus replication. - Highlights: • A putative fusion peptide (FP) region in CSFV E2 protein was shown to be critical for virus growth. • Synthetic FPs were shown to efficiently penetrate into lipid membranes using an in vitro model. • Individual residues in the FP affecting virus replication were identified by reverse genetics. • The same FP residues are also responsible for mediating membrane fusion.« less

A Cost-Effectiveness Analysis of Low-Risk Deliveries: A Comparison of Midwives, Family Physicians and Obstetricians.

PubMed

Walters, Dylan; Gupta, Archna; Nam, Austin E; Lake, Jennifer; Martino, Frank; Coyte, Peter C

2015-08-01

To investigate the cost-effectiveness of in-hospital obstetrical care by obstetricians (OBs), family physicians (FPs) and midwives (MWs) for delivery of low-risk obstetrical patients. Cost-effectiveness analysis from the Ministry of Health perspective using a retrospective cohort study. The time horizon was from hospital admission of a low-risk pregnant patient to the discharge of the mother and infant. Costing data included human resource, intervention and hospital case-mix costs. Interventions measured were induction or augmentation of labour with oxytocin, epidural use, forceps or vacuum delivery and caesarean section. The outcome measured was avoidance of transfer to a neonatal intensive care unit (NICU). Model results were tested using various types of sensitivity analyses. The mean maternal age by provider groups was 29.7 for OBs, 29.8 for FPs and 31.2 for MWs - a statistically higher mean for the MW group. The MW deliveries had lower costs and better outcomes than FPs and OBs. FPs also dominated OB.s The differences in cost per delivery were small, but slightly lower in MW ($5,102) and FP ($5,116) than in OB ($5,188). Avoidance of transfer to an NICU was highest for MW at 94.0% (95% CI: 91.0-97.0), compared with 90.2% for FP (95% CI: 88.2-92.2) and 89.6% for OB (95% CI: 88.6-90.6). The cost-effectiveness of the MW group is diminished by increases in compensation, and the cost-effectiveness of the FP group is sensitive to changes in intervention rates and costs. The MW strategy was the most cost-effective in this hospital setting. Given data limitations to further examine patient characteristics between groups, the overall conservative findings of this study support investments and better integration for MWs in the current system. Copyright © 2015 Longwoods Publishing.

Establishment and advances in the online Serbian food and recipe data base harmonized with EuroFIR™ standards.

PubMed

Gurinović, Mirjana; Milešević, Jelena; Kadvan, Agnes; Djekić-Ivanković, Marija; Debeljak-Martačić, Jasmina; Takić, Marija; Nikolić, Marina; Ranković, Slavica; Finglas, Paul; Glibetić, Maria

2016-02-15

Within the European Food Information Resource Network of Excellence (EuroFIR NoE; FP6) and EuroFIR Nexus (FP7) project paucity in food composition databases (FCDB) in the Central Eastern Europe/Balkan (CEE/B) region was identified. As a member of EuroFIR NoE, the Centre of Research Excellence in Nutrition and Metabolism, Serbia initiated creation of the 1st online Serbian FCDB employing EuroFIR quality framework and CEN Food Data Standard requirements, supporting capacity development and designing the web-based Food Composition Data Management (FCDM) software for FCDB building. The 1st online version of Serbian FCDB was launched in 2007, and then extended with food composition data from other Balkan countries (Balkan Food Platform-Regional FCDB). All foods are indexed using LanguaL Thesaurus and coded with EFSA FoodEx2 coding system. To date, upgraded Serbian FCDB with 1046 foods and 129 traditional/common Serbian composite dishes is a prerequisite for nutritional research in Serbia, CEE/B region and wider Europe. Copyright © 2015 Elsevier Ltd. All rights reserved.

Sustainable Management of Seagrass Meadows: the GEOSS AIP-6 Pilot

NASA Astrophysics Data System (ADS)

Santoro, Mattia; Pastres, Roberto; Zucchetta, Matteo; Venier, Chiara; Roncella, Roberto; Bigagli, Lorenzo; Mangin, Antoine; Amine Taji, Mohamed; Gonzalo Malvarez, Gonzalo; Nativi, Stefano

2014-05-01

Seagrass meadows (marine angiosperm plants) occupy less than 0.2% of the global ocean surface, annually store about 10-18% of the so-called "Blue Carbon", i.e. the Carbon stored in coastal vegetated areas. Recent literature estimates that the flux to the long-term carbon sink in seagrasses represents 10-20% of seagrasses global average production. Such figures can be translated into economic benefits, taking into account that a ton of carbon dioxide in Europe is paid at around 15 € in the carbon market. This means that the organic carbon retained in seagrass sediments in the Mediterranean is worth 138 - 1128 billion €, which represents 6-23 € per square meter. This is 9-35 times more than one square meter of tropical forest soil (0.66 € per square meter), or 5-17 times when considering both the above and the belowground compartments in tropical forests. According the most conservative estimations, about 10% of the Mediterranean meadows have been lost during the last century. To estimate seagrass meadows distribution, a Species Distribution Model (SDM) can be used. SDM is a tool that is used to evaluate the potential distribution of a given species (e.g. Posidonia oceanica for seagrass) on the basis of the features (bio-chemical-physical parameters) of the studied environment. In the framework of the GEOSS (Global Earth Observation System of Systems) initiative, the FP7 project MEDINA developed a showcase as part of the GEOSS Architecture Interoperability Pilot - phase 6 (AIP-6). The showcase aims at providing a tool for the sustainable management of seagrass meadows along the Mediterranean coastline by integrating the SDM with available GEOSS resources. This way, the required input data can be searched, accessed and ingested into the model leveraging the brokering framework of the GEOSS Common Infrastructure (GCI). This framework is comprised of a set of middle-ware components (Brokers) that are in charge of implementing the needed interoperability arrangements to interconnect the heterogeneous and distributed capacities contributing to GEOSS. The presentation discusses such a framework explaining how the input data is discovered, accessed and processed to ingest the model. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n. 282977.

Photoinduced energy and electron transfer processes in hexapyropheophorbide a- fullerene [C(60)] molecular systems.

PubMed

Regehly, Martin; Ermilov, Eugeny A; Helmreich, Matthias; Hirsch, Andreas; Jux, Norbert; Röder, Beate

2007-02-08

The photophysical properties of the novel hexapyropheophorbide a (P6), and hexakis (pyropheophorbide a)-C60 (FP6) were studied and compared with those of hexakis (pyropheophorbide a)-fullerene [5:1] hexaadduct (FHP6). It was found that after light absorption the pyropheophorbide a molecules in all three compounds undergo very efficient energy transfer as well as partly excitonic interactions. The last process results in the formation of energy traps, which could be resolved experimentally. For P6, due to shorter distances between neighboring dye molecules, stronger interactions between pyropheophorbide a units than for FHP6 were observed. As a consequence, the excitation energy is delivered rapidly to traps formed by stacked pyropheophorbide a molecules resulting in the reduction of fluorescence, intersystem crossing, and singlet oxygen quantum yields compared to the values of FHP6. For FP6 the reduction of these values is much stronger due to an additional fast and efficient deactivation process, namely photoinduced electron transfer from pyropheophorbide a to the fullerene moiety. Consequently, FP6 can be considered as a combination of a light-harvesting system consisting of several separate pyropheophorbide a molecules and a charge-separating center.

7 CFR 654.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Federal financially-assisted projects. (i) Watershed Protection and Flood Prevention (WP&FP). See part 622...) Emergency Watershed Protection (EWP). See part 624 of this title. (4) Great Plains Conservation Program (GP...

7 CFR 654.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Federal financially-assisted projects. (i) Watershed Protection and Flood Prevention (WP&FP). See part 622...) Emergency Watershed Protection (EWP). See part 624 of this title. (4) Great Plains Conservation Program (GP...

7 CFR 654.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Federal financially-assisted projects. (i) Watershed Protection and Flood Prevention (WP&FP). See part 622...) Emergency Watershed Protection (EWP). See part 624 of this title. (4) Great Plains Conservation Program (GP...

7 CFR 654.1 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Federal financially-assisted projects. (i) Watershed Protection and Flood Prevention (WP&FP). See part 622...) Emergency Watershed Protection (EWP). See part 624 of this title. (4) Great Plains Conservation Program (GP...

7 CFR 654.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Federal financially-assisted projects. (i) Watershed Protection and Flood Prevention (WP&FP). See part 622...) Emergency Watershed Protection (EWP). See part 624 of this title. (4) Great Plains Conservation Program (GP...

Controlling system for smart hyper-spectral imaging array based on liquid-crystal Fabry-Perot device

NASA Astrophysics Data System (ADS)

Jiang, Xue; Chen, Xin; Rong, Xin; Liu, Kan; Zhang, Xinyu; Ji, An; Xie, Changsheng

2011-11-01

A research for developing a kind of smart spectral imaging detection technique based on the electrically tunable liquidcrystal (LC) FP structure is launched. It has some advantages of low cost, highly compact integration, perfuming wavelength selection without moving any micro-mirror of FP device, and the higher reliability and stability. The controlling system for hyper-spectral imaging array based on LC-FP device includes mainly a MSP430F5438 as its core. Considering the characteristics of LC-FP device, the controlling system can provide a driving signal of 1-10 kHz and 0- 30Vrms for the device in a static driving mode. This paper introduces the hardware designing of the control system in detail. It presents an overall hardware solutions including: (1) the MSP430 controlling circuit, and (2) the operational amplifier circuit, and (3) the power supply circuit, and (4) the AD conversion circuit. The techniques for the realization of special high speed digital circuits, which is necessary for the PCB employed, is also discussed.

Comparison between ultrafine and fine particulate matter collected in Lebanon: Chemical characterization, in vitro cytotoxic effects and metabolizing enzymes gene expression in human bronchial epithelial cells.

PubMed

Borgie, Mireille; Dagher, Zeina; Ledoux, Frédéric; Verdin, Anthony; Cazier, Fabrice; Martin, Perrine; Hachimi, Adam; Shirali, Pirouz; Greige-Gerges, Hélène; Courcot, Dominique

2015-10-01

During the last few years, the induction of toxicological mechanisms by atmospheric ultrafine particles (UFP) has become one of the most studied topics in toxicology and a subject of huge debates. Fine particles (FP) and UFP collected at urban and rural sites in Lebanon were studied for their chemical composition and toxicological effects. UFP were found more enriched in trace elements, secondary inorganic ions, total carbon and organic compounds than FP. For toxicological analysis, BEAS-2B cells were exposed for 24, 48 and 72 h to increasing concentrations of FP, water-UFP suspension (UFPw) and UFP organic extract (UFPorg). Our findings showed that UFP caused earlier alterations of mitochondrial metabolism and membrane integrity from the lowest concentrations. Moreover, a significant induction of CYP1A1, CYP1B1 and AhRR genes expression was showed after cells exposure to UFPorg and to a lesser extent to UFPw and FP samples. Copyright © 2015 Elsevier Ltd. All rights reserved.

Electrically tunable infrared filter based on the liquid crystal Fabry-Perot structure for spectral imaging detection.

PubMed

Zhang, Huaidong; Muhammmad, Afzal; Luo, Jun; Tong, Qing; Lei, Yu; Zhang, Xinyu; Sang, Hongshi; Xie, Changsheng

2014-09-01

An electrically tunable infrared (IR) filter based on the liquid crystal (LC) Fabry-Perot (FP) key structure, which works in the wavelength range from 5.5 to 12 μm, is designed and fabricated successfully. Both planar reflective mirrors with a very high reflectivity of ∼95%, which are shaped by depositing a layer of aluminum (Al) film over one side of a double-sided polished zinc selenide wafer, are coupled into a dual-mirror FP cavity. The LC materials are filled into the FP cavity with a thickness of ∼7.5  μm for constructing the LC-FP filter, which is a typical type of sandwich architecture. The top and bottom mirrors of the FP cavity are further coated by an alignment layer with a thickness of ∼100  nm over Al film. The formed alignment layer is rubbed strongly to shape relatively deep V-grooves to anchor LC molecules effectively. Common optical tests show some particular properties; for instance, the existing three transmission peaks in the measured wavelength range, the minimum full width at half-maximum being ∼120  nm, and the maximum adjustment extent of the imaging wavelength being ∼500  nm through applying the voltage driving signal with a root mean square (RMS) value ranging from 0 to ∼19.8  V. The experiment results are consistent with the simulation, according to our model setup. The spectral images obtained in the long-wavelength IR range, through the LC-FP device driven by the voltage signal with a different RMS value, demonstrates the prospect of the realization of smart spectral imaging and further integrating the LC-FP filter with IR focal plane arrays. The developed LC-FP filters show some advantages, such as electrically tunable imaging wavelength, very high structural and photoelectronic response stability, small size and low power consumption, and a very high filling factor of more than 95% compared with common MEMS-FP spectral imaging approaches.

The COMESEP Alert System

NASA Astrophysics Data System (ADS)

Crosby, Norma; Veronig, Astrid; Rodriguez, Luciano; Vrsnak, Bojan; Vennerstrom, Susanne; Malandraki, Olga; Dalla, Silvia; Srivastava, Nandita; Hesse, Michael; Odstrcil, Dusan; Robbrecht, Eva

2014-05-01

Tools for forecasting geomagnetic storms and solar energetic particle (SEP) radiation storms have been developed under the three-year EU FP7 COMESEP (COronal Mass Ejections and Solar Energetic Particles) collaborative project. To enhance our understanding of the 3D kinematics and interplanetary propagation of coronal mass ejections (CMEs), the structure, propagation and evolution of CMEs have been investigated. In parallel, the sources and propagation of SEPs have been examined and modeled. During the third year of the COMESEP project the produced tools have been validated and implemented into an operational space weather alert system. The COMESEP Alert System provides notifications for the space weather community. To achieve this the system relies on both models and data, the latter including near real-time data as well as historical data. Geomagnetic and SEP radiation storm alerts are based on the COMESEP definition of risk. The COMESEP Alert System has recently been launched. Receiving COMESEP alerts are free of charge, but registration is required. For more information see the project website (http://www.comesep.eu/). This work has received funding from the European Commission FP7 Project COMESEP (263252).

Erratum to: The visual amplification of goal-oriented movements counteracts acquired non-use in hemiparetic stroke patients.

PubMed

Rubio Ballester, Belén; Nirme, Jens; Duarte, Esther; Cuxart, Ampar; Rodriguez, Susana; Verschure, Paul; Duff, Armin

2015-11-27

Unfortunately, in the original version of this article [1] the sentence "This project was supported through ERC project cDAC (FP7-IDEAS-ERC 341196), EC H2020 project socSMCs (H2020-EU.1.2.2. 641321) and MINECO project SANAR (Gobierno de España)" was missing from the acknowledgements.The acknowledgements have been correctly included in full in this erratum.

Technical note: Efficient online source identification algorithm for integration within a contamination event management system

NASA Astrophysics Data System (ADS)

Deuerlein, Jochen; Meyer-Harries, Lea; Guth, Nicolai

2017-07-01

Drinking water distribution networks are part of critical infrastructures and are exposed to a number of different risks. One of them is the risk of unintended or deliberate contamination of the drinking water within the pipe network. Over the past decade research has focused on the development of new sensors that are able to detect malicious substances in the network and early warning systems for contamination. In addition to the optimal placement of sensors, the automatic identification of the source of a contamination is an important component of an early warning and event management system for security enhancement of water supply networks. Many publications deal with the algorithmic development; however, only little information exists about the integration within a comprehensive real-time event detection and management system. In the following the analytical solution and the software implementation of a real-time source identification module and its integration within a web-based event management system are described. The development was part of the SAFEWATER project, which was funded under FP 7 of the European Commission.

Space Gator: a giant leap for fiber optic sensing

NASA Astrophysics Data System (ADS)

Evenblij, R. S.; Leijtens, J. A. P.

2017-11-01

Fibre Optic Sensing is a rapidly growing application field for Photonics Integrated Circuits (PIC) technology. PIC technology is regarded enabling for required performances and miniaturization of next generation fibre optic sensing instrumentation. So far a number of Application Specific Photonics Integrated Circuits (ASPIC) based interrogator systems have been realized as operational system-on-chip devices. These circuits have shown that all basic building blocks are working and complete interrogator on chip solutions can be produced. Within the Saristu (FP7) project several high reliability solutions for fibre optic sensing in Aeronautics are being developed, combining the specifically required performance aspects for the different sensing applications: damage detection, impact detection, load monitoring and shape sensing (including redundancy aspects and time division features). Further developments based on devices and taking into account specific space requirements (like radiation aspects) will lead to the Space Gator, which is a radiation tolerant highly integrated Fibre Bragg Grating (FBG) interrogator on chip. Once developed and qualified the Space Gator will be a giant leap for fibre optic sensing in future space applications.

Who is driving continuing medical education for family medicine?

PubMed

Klein, Douglas; Allan, G Michael; Manca, Donna; Sargeant, Joan; Barnett, Carly

2009-01-01

Considerable time and money are invested in continuing medical education (CME) for family physicians (FPs) but the effectiveness is uncertain. The participation of FPs as coordinators and teachers is not well known. The goal of this project was to describe the role of FPs in organizing and teaching CME events that are accredited for FPs. Information about accredited CME events occurring in Alberta and Nova Scotia was requested from universities, provincial chapters of the College of Family Physicians of Canada, and pharmaceutical companies. Location, coordinating site, organizing committee members, teaching faculty, and format were recorded from each event. The number and proportion of FPs involved in both organizing and teaching CME events accredited for FPs were calculated and compared. A total of 314 CME events were collected, comprising a total of 1,472 hours of CME. From the CME events collected, there were 1,730 organizing committee members and 1,647 teachers. FPs constitute 59% of the organizing committees and 17% of the teachers. Significant differences in the numbers of FP planners and teachers were related to organizing group, format, location, and expected audience composition. The accreditation requirement for FPs on organizing committees likely helps preserve a reasonable proportion of FP organizers but not teachers in FP CME. The proportions of true FP planners and teachers may actually be lower than planning documents indicate. Low level of family physician teachers in CME may be due to FPs' not selecting FP teachers, the FP teaching pool's being inadequate, or the organizing committee's being unaware of FPs who are knowledgeable in particular areas.

Quality and clinical supply considerations of Paediatric Investigation Plans for IV preparations-A case study with the FP7 CloSed project.

PubMed

Hanning, Sara M; Orlu Gul, Mine; Winslade, Jackie; Baarslag, Manuel A; Neubert, Antje; Tuleu, Catherine

2016-09-25

A Paediatric Investigation Plan (PIP) is a development plan that aims to ensure that sufficient data are obtained through studies in paediatrics to support the generation of marketing authorisation of medicines for children. This paper highlights some practical considerations and challenges with respect to PIP submissions and paediatric clinical trials during the pharmaceutical development phase, using the FP7-funded Clonidine for Sedation of Paediatric Patients in the Intensive Care Unit (CloSed) project as a case study. Examples discussed include challenges and considerations regarding formulation development, blinding and randomisation, product labelling and shipment and clinical trial requirements versus requirements for marketing authorisation. A significant quantity of information is required for PIP submissions and it is hoped that future applicants may benefit from an insight into some critical considerations and challenges faced in the CloSed project. Copyright © 2016 Elsevier B.V. All rights reserved.

Accelerator science and technology in Europe 2008-2017

NASA Astrophysics Data System (ADS)

Romaniuk, Ryszard S.

2013-10-01

European Framework Research Projects have recently added a lot of meaning to the building process of the ERA - the European Research Area. Inside this, the accelerator technology plays an essential role. Accelerator technology includes large infrastructure and intelligent, modern instrumentation embracing mechatronics, electronics, photonics and ICT. During the realization of the European research and infrastructure project FP6 CARE 2004-2008 (Coordinated Accelerator Research in Europe), concerning the development of large accelerator infrastructure in Europe, it was decided that a scientific editorial series of peer-reviewed monographs from this research area will be published in close relation with the projects. It was a completely new and quite brave idea to combine a kind of a strictly research publisher with a transient project, lasting only four or five years. Till then nobody did something like that. The idea turned out to be a real success. The publications now known and valued in the accelerator world, as the (CERN-WUT) Editorial Series on Accelerator Science and Technology, is successfully continued in already the third European project EuCARD2 and has logistic guarantees, for the moment, till the 2017, when it will mature to its first decade. During the realization of the European projects EuCARD (European Coordination for Accelerator R&D 2009-2013 and TIARA (Test Infrastructure of Accelerator Research Area in Europe) there were published 18 volumes in this series. The ambitious plans for the nearest years is to publish, hopefully, a few tens of new volumes. Accelerator science and technology is one of a key enablers of the developments in the particle physic, photon physics and also applications in medicine and industry. The paper presents a digest of the research results in the domain of accelerator science and technology in Europe, published in the monographs of the European Framework Projects (FP) on accelerator technology. The succession of CARE, EuCARD and EuCARD Projects is evidently creating a new quality in the European Accelerator Research. It is consolidating the technical and research communities in a new way, completely different than the traditional ones, for example via the periodic topical conferences.

[Effect of probiotic product containing bifidobacteria and biogel from brown algae on the intestinal microflora and parameters of innate immunity in mice with experimental drug dysbacteriosis].

PubMed

Kuznetsova, T A; Makarenkova, I D; Koneva, E L; Aminina, N M; Yakush, E V

2015-01-01

The article represents the results of studying the effect of a new fermented product (FP) containing the probiotic strain Bifidobacterium bifidum 791 and Biogel from brown algae Laminariajaponica on the composition of intestinal microflora and parameters of innate immunity in mice with experimental dysbacteriosis, induced by administration of gentamicin in dose of 25 mg per kg body weight during 7 days. The experimental animals received for 6 weeks in addition to the diet FP, which was 2% of the average volume of feed intake. The FP influence was manifested by more rapid reduction of dyspepsia symptoms, restoration of body weight and balance the intestinal microbiocenosis (increasing of bifido- and lactobacteria, typical E. coli, reducing of the bacteria genus Proteus and Clostridium, elimination of S. aureus). As the results of FP administration we observed the statistically significant reduction of endogenous intoxication values and increasing of the phagocyte activity of neutrophils, related to effector cells of innate immunity, compared with animals not receiving FP. Identified effects of FP are due to both its probiotic properties through the presence of bifidobacteria and immunomodulating and enteral sorbtion activities of alginate component.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loyalka, Sudarshan

High and Very High Temperatures Gas Reactors (HTGRs/VHTRs) have five barriers to fission product (FP) release: the TRISO fuel coating, the fuel elements, the core graphite, the primary coolant system, and the reactor building. This project focused on measurements and computations of FP diffusion in graphite, FP adsorption on graphite and FP interactions with dust particles of arbitrary shape. Diffusion Coefficients of Cs and Iodine in two nuclear graphite were obtained by the release method and use of Inductively Coupled Plasma-Mass Spectroscopy (ICP-MS) and Instrumented Neutron Activation Analysis (INAA). A new mathematical model for fission gas release from nuclear fuelmore » was also developed. Several techniques were explored to measure adsorption isotherms, notably a Knudsen Effusion Mass Spectrometer (KEMS) and Instrumented Neutron Activation Analysis (INAA). Some of these measurements are still in progress. The results will be reported in a supplemental report later. Studies of FP interactions with dust and shape factors for both chain-like particles and agglomerates over a wide size range were obtained through solutions of the diffusion and transport equations. The Green's Function Method for diffusion and Monte Carlo technique for transport were used, and it was found that the shape factors are sensitive to the particle arrangements, and that diffusion and transport of FPs can be hindered. Several journal articles relating to the above work have been published, and more are in submission and preparation.« less

Methodological concerns for determining power output in the jump squat.

PubMed

Cormie, Prue; Deane, Russell; McBride, Jeffrey M

2007-05-01

The purpose of this study was to investigate the validity of power measurement techniques during the jump squat (JS) utilizing various combinations of a force plate and linear position transducer (LPT) devices. Nine men with at least 6 months of prior resistance training experience participated in this acute investigation. One repetition maximums (1RM) in the squat were determined, followed by JS testing under 2 loading conditions (30% of 1RM [JS30] and 90% of 1RM [JS90]). Three different techniques were used simultaneously in data collection: (a) 1 linear position transducer (1-LPT); (b) 1 linear position transducer and a force plate (1-LPT + FP); and (c) 2 linear position transducers and a force place (2-LPT + FP). Vertical velocity-, force-, and power-time curves were calculated for each lift using these methodologies and were compared. Peak force and peak power were overestimated by 1-LPT in both JS30 and JS90 compared with 2-LPT + FP and 1-LPT + FP (p

Comparison of multiple atmospheric chemistry schemes in C-IFS

NASA Astrophysics Data System (ADS)

Flemming, Johannes; Huijnen, Vincent; Arteta, Joaquim; Stein, Olaf; Inness, Antje; Josse, Beatrice; Schultz, Martin; Peuch, Vincent-Henri

2013-04-01

As part of the MACCII -project (EU-FP7) ECMWF's integrated forecast system (IFS) is being extended by modules for chemistry, deposition and emission of reactive gases. This integration of the chemistry complements the integration of aerosol processes in IFS (Composition-IFS). C-IFS provides global forecasts and analysis of atmospheric composition. Its main motivation is to utilize the IFS for the assimilation of satellite observation of atmospheric composition. Furthermore, the integration of chemistry packages directly into IFS will achieve better consistency in terms of the treatment of physical processes and has the potential for simulating interactions between atmospheric composition and meteorology. Atmospheric chemistry in C-IFS can be represented by the modified CB05 scheme as implemented in the TM5 model and the RACMOBUS scheme as implemented in the MOCAGE model. An implementation of the scheme of the MOZART 3.5 model is ongoing. We will present the latest progress in the development and application of C-IFS. We will focus on the comparison of the different chemistry schemes in an otherwise identical C-IFS model setup (emissions, meteorology) as well as in their original Chemistry and Transport Model setup.

[Relationship between body fat and creatinine clearence in adults with and without diabetes mellitus].

PubMed

Romero-Campos, Sandra; Viveros-Cortés, Ángel; Medina-Escobedo, Martha; Sansores-España, Delia; Villanueva-Jorge, Salha

2015-01-01

Obesity is a risk factor for renal damage. This study aimed to determine the relationship between body fat percent and creatinine clearance in adult patients with and without type 2 diabetes mellitus (T2DM). An observational prospective cross-correlation study was carried out among adults with and without T2DM between 18 and 60 years of age. It was determined the time of evolution with T2DM, as well as fat percentage (FP), body mass index (BMI), creatinine clearance (Cockroft-Gault [CrCCG]), glycemia and micro/macroalbuminuria. The correlation between CrCCG and FP was determined by Spearman's test. 174 subjects were included in this study. Obesity by BMI and FP in subjects with and without T2DM was similar. Of the studied subjects, 12.6 % didn't have kidney damage and 50.7 % had increased risk of renal disease; the frequencies for stages 1-4 of kidney damage were 12.0, 20.1, 4.0 and 0.6 %, respectively. Spearman's test showed a direct relationship between FP and CrCCG, higher in diabetics (r = 0.418, p < 0.0001) than in non-diabetics (p = 0.327, p < 0.0001). The FP was correlated directly with the CrCCG in subjects with and without T2DM; therefore, we can conclude that the greater the kidney damage, the smaller the fat porcentage in the study sample.

Efficacy of S-flurbiprofen plaster in knee osteoarthritis treatment: Results from a phase III, randomized, active-controlled, adequate, and well-controlled trial.

PubMed

Yataba, Ikuko; Otsuka, Noboru; Matsushita, Isao; Matsumoto, Hideo; Hoshino, Yuichi

2017-01-01

S-flurbiprofen plaster (SFPP) is a novel non-steroidal anti-inflammatory drug (NSAID) patch, intended for topical treatment for musculoskeletal diseases. This trial was conducted to examine the effectiveness of SFPP using active comparator, flurbiprofen (FP) patch, on knee osteoarthritis (OA) symptoms. This was a phase III, multi-center, randomized, adequate, and well-controlled trial, both investigators and patients were blinded to the assigned treatment. Enrolled 633 knee OA patients were treated with either SFPP or FP patch for two weeks. The primary endpoint was improvement in knee pain on rising from the chair as assessed by visual analogue scale (rVAS). Safety was evaluated through adverse events (AEs). The change in rVAS was 40.9 mm in SFPP group and 30.6 mm in FP patch group (p < 0.001). The incidence of drug-related AEs at the application site was 9.5% (32 AEs, 29 mild and 3 moderate) in SFPP and 1.6% in FP patch (p < 0.001). Withdrawals due to AE were five in SFPP and one in FP patch. The superiority of SFPP in efficacy was demonstrated. Most of AEs were mild and few AEs led to treatment discontinuation. Therefore, SFPP provides an additional option for knee OA therapy.

The PPP Simulator: User’s Manual and Report

DTIC Science & Technology

1986-11-01

simulator: Script started on Thu Aug 28 09:16:15 1986 1 ji] -> ppp -d Benchmarks/Par/ccon6.w pau load /a/hprg’fagin/ PPPl /Benchmarks/Par,’concatOP .w Capace...EOF ) putc( c, stdout ) #else if(( fp = fopen("/a/hprg/fagin/ PPPl /notes’, fir" ))!NULL) while(( c = getc(fp)) != EOF ) putc( c, stdout ) #erndif if...hprg/fagin/ PPPl /bitl.d’, fir" ) =NULL) lddsptbl( fp, bi-tbl ); while((--argc > 0) && ((*.+argv)[0]= -I for( s =argv[0]+l; *s!=’\\0’ s++ A -A Aug 18 16

Influence of ferrule preparation with or without glass fiber post on fracture resistance of endodontically treated teeth

PubMed Central

de LIMA, Alexandra Furtado; SPAZZIN, Aloísio Oro; GALAFASSI, Daniel; CORRER-SOBRINHO, Lourenço; CARLINI-JÚNIOR, Bruno

2010-01-01

Objective This study evaluated the effect of ferrule preparation (Fp) on the fracture resistance of endodontically treated teeth, restored with composite resin cores with or without glass fiber posts. Material and Methods Forty-four bovine teeth were sectioned 19 or 17 mm (2 mm ferrule) from the apex, endodontically treated and assigned to four groups (n = 11): Group 1: Fp and post; Group 2: Fp and without post; Group 3: without Fp and with post; Group 4: without Fp and without post. All specimens were restored with composite resin core and metal crown. Specimens were subjected to fracture resistance testing in a universal testing machine at a crosshead speed of 0.5 mm/min. The data were analyzed by two-way ANOVA and Tukey’s tests (α=0.05). Results The mean fracture resistance values were as follows: Group 1: 573.3 N; Group 2: 552.5 N; Group 3: 275.3 N; Group 4: 258.6 N. Significantly higher fracture resistance was found for the groups with Fp (p<0.001). Conclusion There was no statistically significant interaction between the "Fp" and "post" factors (p = 0.954). The ferrule preparation increased the fracture resistance of endodontically treated teeth. However, the use of glass fiber post showed no significant influence on the fracture resistance. PMID:20835570

The Mediterranean Supersite Volcanoes (MED-SUV) Project: an overview

NASA Astrophysics Data System (ADS)

Puglisi, Giuseppe

2013-04-01

In response to the EC call ENV.2012.6.4-2 (Long-term monitoring experiments in geologically active regions of Europe prone to natural hazards: the Supersite concept - FP7-ENV-2012-two-stage) a wide community of volcanological institutions proposed the project Mediterranean Supersite Volcanoes (MED-SUV), which is in the negotiation phase at the time of writing. The Consortium is composed by 18 European University and research institutes, four Small or Medium Enterprises (SME) and two non-European University and research institutes. MED-SUV will improve the consortium capacity of assessment of volcanic hazards in Supersites of Southern Italy by optimising and integrating existing and new observation/monitoring systems, by a breakthrough in understanding of volcanic processes and by increasing the effectiveness of the coordination between the scientific and end-user communities. More than 3 million of people are exposed to potential volcanic hazards in a large region in the Mediterranean Sea, where two among the largest European volcanic areas are located: Mt. Etna and Campi Flegrei/Vesuvius. This project will fully exploit the unique detailed long-term in-situ monitoring data sets available for these volcanoes and integrate with Earth Observation (EO) data, setting the basic tools for a significant step ahead in the discrimination of pre-, syn- and post-eruptive phases. The wide range of styles and intensities of volcanic phenomena observed on these volcanoes, which can be assumed as archetypes of 'closed conduit ' and 'open conduit' volcano, together with the long-term multidisciplinary data sets give an exceptional opportunity to improve the understanding of a very wide spectrum of geo-hazards, as well as implementing and testing a large variety of innovative models of ground deformation and motion. Important impacts on the European industrial sector are expected, arising from a partnership integrating the scientific community and SMEs to implement together new observation/monitoring sensors/systems. Specific experiments and studies will be carried out to improve our understanding of the volcanic internal structure and dynamics, as well as to recognise signals related to impending unrest or eruption. Hazard quantitative assessment will benefit by the outcomes of these studies and by their integration into the cutting edge monitoring approaches thus leading to a step-change in hazard awareness and preparedness and leveraging the close relationship between scientists, SMEs, and end-users.

Indonesia to become a larger donor to the UNFPA, Country Director J.S. Parsons predicts.

PubMed

Mann, R

1992-08-01

The UN Population Fund (UNFPA) is influential with governments because of its international coordinating role in line with the Amsterdam Declaration of 1989. The present shortage of funds for UNFPA can be traced to the weak world economy, monetary needs in eastern Europe and in the former USSR, and the stagnation of voluntary contributions to UNFPA. The reduction of funding has affected the Indonesian family planning (FP) program called BKKBN. Indonesia is a priority country for UNFPA because of the self-reliance and success of the national program; the efficient utilization of a staff of 46,000 working for 19 million acceptors; the total fertility rate drop from 5.6 in 1971 to 3.1 in 1991; a 95% and 93% knowledge of FP and contraceptives among married women, respectively; and the national contraceptive prevalence is 49.7%. Smaller private projects and strategies are recommended for nationwide adaptation. Unfulfilled needs include adolescent reproductive health care, slums, quality of services, and reaching remote fishing or highland communities. BKKBN has been assisting its Vietnamese counterpart with technical advice which is in accordance with the international objectives of UNFPA. BKKBN has also assisted Bangladesh, Pakistan, Nigeria, and Kenya. Indonesia could contribute condoms, pills, and IUDs to the UNFPA effort to increase its share, although not on the same order as Japan and the Netherlands. The 4th Asian and Pacific conference is scheduled to be held in Bali in August 1992 in preparation for the World Population Conference to be arranged in Egypt in 1994 with an agenda of policies and strategies for all the regions of Asia, Pacific, Middle East, and Latin America. The formulation of a World Population Declaration is envisioned on South to South cooperation on FP beholding BKKBN's experience in FP information exchange with other countries.

Novel Hybrid Ablative/Ceramic Heatshield for Earth Atmospheric Re-Entry

NASA Astrophysics Data System (ADS)

Barcena, J.; Florez, S.; Perez, B.; Pinaud, G.; Bouilly, J.-M.; Fischer, W. P. P.; de Montburn, A.; Descomps, M.; Zuber, C.; Rotaermel, W.; Hald, H.; Pereira, C.; Mergia, K.; Triantou, K.; Marinou, A.; Vekinis, G.; Ionescu, G.; Ban, C.; Stefan, A.; Leroy, V.; Bernard, D.; Massuti, B.; Herdrich, G.

2014-06-01

Original approaches based on ablative materials and novel TPS solutions are required for space applications, where resistance to extreme oxidative environments and high temperatures are required. For future space exploration the demands for the thermal shield go beyond the current state-of-the-art. Therefore, the development of new thermal protection materials and systems at a reasonable mass budget is absolutely essential to ensure European non-dependence on corresponding restricted technologies. The three year long FP7 project HYDRA aims at the development of a novel thermal protection system through the integration of a low density ablative outer-shield on top of an advanced thermo-structural ceramic composite layer and will provide an innovative technology solution consistent with the capabilities of European technologies and material providers. This paper summarizes the current status of the scientific activities carried out after two years of progress in terms of design, integration and verification of a robust and lightweight thermal shield solution for atmospheric earth re-entry.

Integration Assessment of Visiting Vehicle Induced Electrical Charging of the International Space Station Structure

NASA Technical Reports Server (NTRS)

Kramer, Leonard; Kerslake, Thomas W.; Galofaro, Joel T.

2010-01-01

The International Space Station (ISS) undergoes electrical charging in low Earth orbit (LEO) due to positively biased, exposed conductors on solar arrays that collect electrical charges from the space plasma. Exposed solar array conductors predominately collect negatively charged electrons and thus drive the metal ISS structure electrical ground to a negative floating potential (FP) relative to plasma. This FP is variable in location and time as a result of local ionospheric conditions. ISS motion through Earth s magnetic field creates an addition inductive voltage up to 20 positive and negative volts across ISS structure depending on its attitude and location in orbit. ISS Visiting Vehicles (VVs), such as the planned Orion crew exploration vehicle, contribute to the ISS plasma charging processes. Upon physical contact with ISS, the current collection properties of VVs combine with ISS. This is an ISS integration concern as FP must be controlled to minimize arcing of ISS surfaces and ensure proper management of extra vehicular activity crewman shock hazards. This report is an assessment of ISS induced charging from docked Orion vehicles employing negatively grounded, 130 volt class, UltraFlex (ATK Space Systems) solar arrays. To assess plasma electron current collection characteristics, Orion solar cell test coupons were constructed and subjected to plasma chamber current collection measurements. During these tests, coupon solar cells were biased between 0 and 120 V while immersed in a simulated LEO plasma. Tests were performed using several different simulated LEO plasma densities and temperatures. These data and associated theoretical scaling of plasma properties, were combined in a numerical model which was integrated into the Boeing Plasma Interaction Model. It was found that the solar array design for Orion will not affect the ISS FP by more than about 2 V during worst case charging conditions. This assessment also motivated a trade study to determine acceptable plasma electron current levels that can be collected by a single or combined fleet of ISS-docked VVs.

Cross-frequency synchronization connects networks of fast and slow oscillations during visual working memory maintenance

PubMed Central

Siebenhühner, Felix; Wang, Sheng H; Palva, J Matias; Palva, Satu

2016-01-01

Neuronal activity in sensory and fronto-parietal (FP) areas underlies the representation and attentional control, respectively, of sensory information maintained in visual working memory (VWM). Within these regions, beta/gamma phase-synchronization supports the integration of sensory functions, while synchronization in theta/alpha bands supports the regulation of attentional functions. A key challenge is to understand which mechanisms integrate neuronal processing across these distinct frequencies and thereby the sensory and attentional functions. We investigated whether such integration could be achieved by cross-frequency phase synchrony (CFS). Using concurrent magneto- and electroencephalography, we found that CFS was load-dependently enhanced between theta and alpha–gamma and between alpha and beta-gamma oscillations during VWM maintenance among visual, FP, and dorsal attention (DA) systems. CFS also connected the hubs of within-frequency-synchronized networks and its strength predicted individual VWM capacity. We propose that CFS integrates processing among synchronized neuronal networks from theta to gamma frequencies to link sensory and attentional functions. DOI: http://dx.doi.org/10.7554/eLife.13451.001 PMID:27669146

Serum extravasation and cytoskeletal alterations following traumatic brain injury in rats. Comparison of lateral fluid percussion and cortical impact models.

PubMed

Hicks, R R; Baldwin, S A; Scheff, S W

1997-01-01

Disruption of the blood-brain barrier (BBB) and neuronal cytoskeletal damage were evaluated in two commonly used rat models of traumatic brain injury. Adult rats received a lateral cortical impact (CI) or lateral fluid percussion (FP) injury of mild or moderate severity or a sham procedure. Six hours after trauma, the brains were removed and analyzed with immunocytochemical techniques for alterations in the serum protein, IgG, and the cytoskeletal protein, microtubule-associated protein 2 (MAP2). Both models induced profound alterations in these proteins in the ipsilateral cortex and hippocampus compared to sham-injured controls. Following an injury of moderate severity, the CI injury resulted in greater IgG extravasation in the cortex and hippocampus than the FP injury. Conversely, after a mild injury, IgG extravasation in the hippocampus was greater for FP than CI. All of the animals in the CI group and most of the FP group showed a loss of MAP2 in the hippocampus. The specific subregions within the cortex and hippocampus that were affected by the injury varied between models, despite having identical impact sites. These data demonstrate that there are both similarities and differences between a CI and FP injury on vascular and neuronal cystoskeletal integrity, which should be considered when utilizing these animal models to study selected features of human head injury.

Optimization of sampling pattern and the design of Fourier ptychographic illuminator.

PubMed

Guo, Kaikai; Dong, Siyuan; Nanda, Pariksheet; Zheng, Guoan

2015-03-09

Fourier ptychography (FP) is a recently developed imaging approach that facilitates high-resolution imaging beyond the cutoff frequency of the employed optics. In the original FP approach, a periodic LED array is used for sample illumination, and therefore, the scanning pattern is a uniform grid in the Fourier space. Such a uniform sampling scheme leads to 3 major problems for FP, namely: 1) it requires a large number of raw images, 2) it introduces the raster grid artefacts in the reconstruction process, and 3) it requires a high-dynamic-range detector. Here, we investigate scanning sequences and sampling patterns to optimize the FP approach. For most biological samples, signal energy is concentrated at low-frequency region, and as such, we can perform non-uniform Fourier sampling in FP by considering the signal structure. In contrast, conventional ptychography perform uniform sampling over the entire real space. To implement the non-uniform Fourier sampling scheme in FP, we have designed and built an illuminator using LEDs mounted on a 3D-printed plastic case. The advantages of this illuminator are threefold in that: 1) it reduces the number of image acquisitions by at least 50% (68 raw images versus 137 in the original FP setup), 2) it departs from the translational symmetry of sampling to solve the raster grid artifact problem, and 3) it reduces the dynamic range of the captured images 6 fold. The results reported in this paper significantly shortened acquisition time and improved quality of FP reconstructions. It may provide new insights for developing Fourier ptychographic imaging platforms and find important applications in digital pathology.

The imperative of functional integration for achievement of MDGs.

PubMed

Mohamud, Khalif Bile

2009-09-01

Pakistan launched its Maternal, Neonatal and Child Health (MNCH) programme in 2006 in collaboration with the World Health Organization (WHO) and other partners to bridge gaps and upscale interventions aimed at reducing mortality and achieving the Millennium Development Goals (MDGs). The country will have an uphill task in meeting by 2020, the 2015 targets set for attainment of MDGs 4 and 5. The current Contraceptive Prevalence Rate (CPR) level of 30% is considerably below the 60% target set for 2020 and the current Total Fertility Rate (TFR), estimated at 4, is significantly higher than the set target of 2.1. Similarly, the Infant Mortality Rate (IMR) of 78 per 1,000 live births is lagging behind the MDG target of 40 per 1,000 live births, while the Maternal Mortality Ratio (MMR) of 276 per 105 live births is higher than the MDG target of 140 per 105 live births. With the rural population at an added disadvantage by reporting 82% and 40% higher MMR and IMR respectively-relative to the population of urban and major cities-reducing the current population growth rate of about 1.7% to 1.3% in the envisaged limited timeframe appears challenging. To overcome these programmatic impediments, the existing fragmentation in implementation of MNCH/Reproductive Health (RH) and Family Planning (FP) services needs to be urgently addressed. To respond to this call, the ministries of Health and Population made a joint commitment at the end of 2008 to bring about functional integration by delivering the MNCH/RH/FP services in a unified manner and by setting up effective institutional, strategic and operational mechanisms that can enhance the implementation process. To significantly reduce IMR and MMR and improve RH/FP outcomes, the two ministries must challenge the status quo and promote the coordination of health and population policies, improve MNCH/RF and FP management practices including monitoring and supervision, deploy, train and motivate the health workforce and strengthen the health system. Functional integration must also aim at ensuring use of appropriate technologies and uninterrupted provision of supplies and equipment. This viewpoint, which is related to the Heartfile Report, aims at diagnosing outstanding challenges at the field level, as well as factors contributing to successful implementation of MNCH/RH and FP and their progress towards achieving Millennium Development Goals (MDGs) 4 and 5.

Fission products and nuclear fuel behaviour under severe accident conditions part 1: Main lessons learnt from the first VERDON test

NASA Astrophysics Data System (ADS)

Pontillon, Y.; Geiger, E.; Le Gall, C.; Bernard, S.; Gallais-During, A.; Malgouyres, P. P.; Hanus, E.; Ducros, G.

2017-11-01

This paper describes the first VERDON test performed at the end of September 2011 with special emphasis on the behaviour of fission products (FP) and actinides during the accidental sequence itself. Two other papers discuss in detail the post-test examination results (SEM, EPMA and SIMS) of the VERDON-1 sample. The first VERDON test was devoted to studying UO2 fuel behaviour and fission product releases under reducing conditions at very high temperature (∼2883 K), which was able to confirm the very good performance of the VERDON loop. The fuel sample did not lose its integrity during this test. According to the FP behaviour measured by the online gamma station (fuel sight), the general classification of the FP in relation to their released fraction is very accurate, and the burn-up effect on the release rate is clearly highlighted.

Active Aging and Elderly's Quality of Life: Comparing the Impact on Literature of Projects Funded by the European Union and USA.

PubMed

Kirilov, I; Atzeni, M; Perra, A; Moro, D; Carta, M G

2018-01-01

The objective of this research is to verify whether European projects on Active Aging (AA) and Elderly Quality of Life (Qol) funded by the Seventh Framework Programme (FP7) produce an impact on literature similar to projects funded by the National Health Institute (NHI) of the United States on international literature using well-known bibliometric indicators. This effort may be useful in developing standardized and replicable procedures. Fifteen randomly selected projects on AA and Elderly Qol concluded in August 2017 and funded by FP7 were compared to similar projects funded by the US NHI with reference to papers published (Scopus and Scholar), papers published in Q1 journals, and the number of citations of the papers linked to the projects. In all the indicators considered, the European projects showed no difference with the US NHI projects. The EU-funded AA and Qol Elderly projects have an impact on scientific literature comparable to projects funded in the United States by the NHI Agency.Our results are consistent with the data on general medical research, which indicates that, European research remains at a high level of competitiveness.In this experimental study, our methodology appeared to be convincing and reliable and it could be applied to the extent of the impact of more extensive research areas.Our research did not evaluate the relationship between funding required by research and scientific productivity.

Solar system plasma Turbulence: Observations, inteRmittency and Multifractals

NASA Astrophysics Data System (ADS)

Echim, Marius M.

2016-04-01

The FP7 project STORM is funded by the European Commission to "add value to existing data bases through a more comprehensive interpretation". STORM targets plasma and magnetic field databases collected in the solar wind (Ulysses and also some planetary missions), planetary magnetospheres (Venus Express, Cluster, a few orbits from Cassini), cometary magnetosheaths (e.g. Haley from Giotto observations). The project applies the same package of analysis methods on geomagnetic field observations from ground and on derived indices (e.g. AE, AL, AU, SYM-H). The analysis strategy adopted in STORM is built on the principle of increasing complexity, from lower (like, e.g., the Power Spectral Density - PSD) to higher order analyses (the Probability Distribution Functions - PDFs, Structure Functions - SFs, Fractals and Multifractals - MFs). Therefore STORM targets not only the spectral behavior of turbulent fluctuations but also their topology and scale behavior inferred from advanced mathematical algorithms and geometrical-like analogs. STORM started in January 2013 and ended in December 2015. We will report on a selection of scientific and technical achievements and will highlight: (1) the radial evolution of solar wind turbulence and intermittency based on Ulysses data with some contributions from Venus Express and Cluster; (2) comparative study of fast and slow wind turbulence and intermittency at solar minimum; (3) comparative study of the planetary response (Venus and Earth magnetosheaths) to turbulent solar wind; (4) the critical behavior of geomagnetic fluctuations and indices; (5) an integrated library for non-linear analysis of time series that includes all the approaches adopted in STORM to investigate solar system plasma turbulence. STORM delivers an unprecedented volume of analysed data for turbulence. The project made indeed a systematic survey, orbit by orbit, of data available from ESA repositories and Principal Investigators and provides results ordered as a function of the targeted system (solar wind/magnetospheres/geomagnetic indices), solar cycle phase (minimum versus maximum), type of result (PSDs, PDFs, Multifractals). The results catalogues, available online from http://www.storm-fp7.eu, include 4094 PSD spectra, 9566 PDFs and 15633 multifractal spectra (from partition function and respectively Rank Ordered (ROMA) formalisms). These results are obtained at solar maximum (2001-2002, both in the solar wind and the terrestrial magnetosheath) and solar minimum (1997-1998 in the solar wind, 2007-2008 in the solar wind, Venus and Earth magnetosheath and selected regions of the magnetosphere). Research supported by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 313038/STORM.

Numerical Calculation of the Peaking Factor of a Water-Cooled W/Cu Monoblock for a Divertor

NASA Astrophysics Data System (ADS)

Han, Le; Chang, Haiping; Zhang, Jingyang; Xu, Tiejun

2015-09-01

In order to accurately predict the incident critical heat flux (ICHF, the heat flux at the heated surface when CHF occurs) of a water-cooled W/Cu monoblock for a divertor, the exact knowledge of its peaking factors (fp) under one-sided heating conditions with different design parameters is a key issue. In this paper, the heat conduction in the solid domain of a water-cooled W/Cu monoblock is calculated numerically by assuming the local heat transfer coefficients (HTC) of the cooling wall to be functions of the local wall temperature, so as to obtain fp. The reliability of the calculation method is validated by an experimental example result, with the maximum error of 2.1% only. The effects of geometric and flow parameters on the fp of a water-cooled W/Cu monoblock are investigated. Within the scope of this study, it is shown that the fp increases with increasing dimensionless W/Cu monoblock width and armour thickness (the shortest distance between the heated surface and Cu layer), and the maximum increases are 43.8% and 22.4% respectively. The dimensionless W/Cu monoblock height and Cu thickness have little effect on fp. The increase of Reynolds number and Jakob number causes the increase of fp, and the maximum increases are 6.8% and 9.6% respectively. Based on the calculated results, an empirical correlation on peaking factor is obtained via regression. These results provide a valuable reference for the thermal-hydraulic design of water-cooled divertors. supported by National Magnetic Confinement Fusion Science Program of China (No. 2010GB104005) and Funding of Jiangsu Innovation Program for Graduate Education, China (CXLX12_0170), the Fundamental Research Funds for the Central Universities of China

Modeling the greenhouse gas budget of straw returning in China: feasibility of mitigation and countermeasures.

PubMed

Lu, Fei; Wang, Xiao-Ke; Han, Bing; Ouyang, Zhi-Yun; Zheng, Hua

2010-05-01

Straw returning is considered to be one of the most promising carbon sequestration measures in China's cropland. A compound model, namely "Straw Returning and Burning Model-Expansion" (SRBME), was built to estimate the net mitigation potential, economic benefits, and air pollutant reduction of straw returning. Three scenarios, that is, baseline, "full popularization of straw returning (FP)," and "full popularization of straw returning and precision fertilization (FP + P)," were set to reflect popularization of straw returning. The results of the SRBME indicated that (1) compared with the soil carbon sequestration of 13.37 Tg/yr, the net mitigation potentials, which were 6.328 Tg/yr for the FP scenario and 9.179 Tg/yr for the FP + P scenario, had different trends when the full budget of the greenhouse gases was considered; (2) when the feasibility in connection with greenhouse gas (GHG) mitigation, economic benefits, and environmental benefits was taken into consideration, straw returning was feasible in 15 provinces in the FP scenario, with a total net mitigation potential of 7.192 TgCe/yr and the total benefits of CNY 1.473 billion (USD 216.6 million); (3) in the FP + P scenario, with the implementation of precision fertilization, straw returning was feasible in 26 provinces with a total net mitigation potential of 10.39 TgCe/yr and the total benefits of CNY 5.466 billion (USD 803.8 million); (4) any extent of change in the treatment of straw from being burnt to being returned would contribute to air pollution reduction; (5) some countermeasures, such as CH(4) reduction in rice paddies, precision fertilization, financial support, education and propaganda, would promote the feasibility of straw returning as a mitigation measure.

The Effect of Low Ambient Relative Humidity on Physical Performance and Perceptual Responses during Load Carriage.

PubMed

Mekjavic, Igor B; Ciuha, Ursa; Grönkvist, Mikael; Eiken, Ola

2017-01-01

Introduction: The study evaluated the effect of low ambient relative humidity on physical performance and perceptual responses during load carriage in a hot environment. Methods: Ten heat-unacclimatized male subjects participated in three 130-min trials, during which they walked on a treadmill, carrying a load of ~35 kg, at a speed of 3.2 km.h -1 , with an incident wind at the same velocity and ambient temperature at 45°C. Each trial commenced with a 10-min baseline at 20°C and 50% relative humidity (RH), the subjects transferred to a climatic chamber and commenced their simulated hike, comprising two 50-min walks separated by a 20-min rest period. In two, full protective equipment (FP) trials, RH was 10% (partial pressure of water vapor, p H 2 O = 7.2 mmHg) in one (FP10), and 20% (p H 2 O = 14.4 mmHg; FP20) in the other. In the control trial, subjects were semi-nude (SN) and carried the equipment in their backpacks; RH was 20%. Measurements included oxygen uptake, ventilation, heart rate, rectal and skin temperatures, heat flux, temperature perception, and thermal comfort. Results: In FP20, four subjects terminated the trial prematurely due to signs of heat exhaustion; there were no such signs in FP10 or SN. Upon completion of the trials, pulmonary ventilation, heart rate, and rectal temperature were lower in FP10 (33 ± 5 l/min; 128 ± 21 bpm; 38.2 ± 0.4°C) and SN (34 ± 4 l/min; 113 ± 18 bpm; 38.1 ± 0.4°C than in FP20 (39 ± 8 l/min; 145 ± 12 bpm; 38.6 ± 0.4°C). Evaporation was significantly greater in the SN compared to FP10 and FP20 trials. FP10 was rated thermally more comfortable than FP20. Conclusion: A lower ambient partial pressure of water vapor, reflected in a lower ambient relative humidity, improved cardiorespiratory, thermoregulatory, and perceptual responses during load carriage.

The Effect of Low Ambient Relative Humidity on Physical Performance and Perceptual Responses during Load Carriage

PubMed Central

Mekjavic, Igor B.; Ciuha, Ursa; Grönkvist, Mikael; Eiken, Ola

2017-01-01

Introduction: The study evaluated the effect of low ambient relative humidity on physical performance and perceptual responses during load carriage in a hot environment. Methods: Ten heat-unacclimatized male subjects participated in three 130-min trials, during which they walked on a treadmill, carrying a load of ~35 kg, at a speed of 3.2 km.h−1, with an incident wind at the same velocity and ambient temperature at 45°C. Each trial commenced with a 10-min baseline at 20°C and 50% relative humidity (RH), the subjects transferred to a climatic chamber and commenced their simulated hike, comprising two 50-min walks separated by a 20-min rest period. In two, full protective equipment (FP) trials, RH was 10% (partial pressure of water vapor, pH2O = 7.2 mmHg) in one (FP10), and 20% (pH2O = 14.4 mmHg; FP20) in the other. In the control trial, subjects were semi-nude (SN) and carried the equipment in their backpacks; RH was 20%. Measurements included oxygen uptake, ventilation, heart rate, rectal and skin temperatures, heat flux, temperature perception, and thermal comfort. Results: In FP20, four subjects terminated the trial prematurely due to signs of heat exhaustion; there were no such signs in FP10 or SN. Upon completion of the trials, pulmonary ventilation, heart rate, and rectal temperature were lower in FP10 (33 ± 5 l/min; 128 ± 21 bpm; 38.2 ± 0.4°C) and SN (34 ± 4 l/min; 113 ± 18 bpm; 38.1 ± 0.4°C than in FP20 (39 ± 8 l/min; 145 ± 12 bpm; 38.6 ± 0.4°C). Evaporation was significantly greater in the SN compared to FP10 and FP20 trials. FP10 was rated thermally more comfortable than FP20. Conclusion: A lower ambient partial pressure of water vapor, reflected in a lower ambient relative humidity, improved cardiorespiratory, thermoregulatory, and perceptual responses during load carriage. PMID:28729839

Integration of E. coli aroG-pheA tandem genes into Corynebacterium glutamicum tyrA locus and its effect on L-phenylalanine biosynthesis

PubMed Central

Liu, Dong-Xin; Fan, Chang-Sheng; Tao, Ju-Hong; Liang, Guo-Xin; Gao, Shan-E; Wang, Hai-Jiao; Li, Xin; Song, Da-Xin

2004-01-01

AIM: To study the effect of integration of tandem aroG-pheA genes into the tyrA locus of Corynebacterium glutamicum (C. glutamicum) on the production of L-phenylalanine. METHODS: By nitrosoguanidine mutagenesis, five p-fluorophenylalanine (FP)-resistant mutants of C.glutamicum FP were selected. The tyrA gene encoding prephenate dehydrogenase (PDH) of C.glutamicum was amplified by polymerase chain reaction (PCR) and cloned on the plasmid pPR. Kanamycin resistance gene (Km) and the PBF-aroG-pheA-T (GA) fragment of pGA were inserted into tyrA gene to form targeting vectors pTK and pTGAK, respectively. Then, they were transformed into C.glutamicum FP respectively by electroporation. Cultures were screened by a medium containing kanamycin and detected by PCR and phenotype analysis. The transformed strains were used for L-phenylalanine fermentation and enzyme assays. RESULTS: Engineering strains of C.glutamicum (Tyr-) were obtained. Compared with the original strain, the transformed strain C. glutamicum GAK was observed to have the highest elevation of L-phenylalanine production by a 1.71-fold, and 2.9-, 3.36-, and 3.0-fold in enzyme activities of chorismate mutase, prephenate dehydratase and 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, respectively. CONCLUSION: Integration of tandem aroG-pheA genes into tyrA locus of C. glutamicum chromosome can disrupt tyrA gene and increase the yield of L-phenylalanine production. PMID:15534933

Knowledge management for systems biology a general and visually driven framework applied to translational medicine.

PubMed

Maier, Dieter; Kalus, Wenzel; Wolff, Martin; Kalko, Susana G; Roca, Josep; Marin de Mas, Igor; Turan, Nil; Cascante, Marta; Falciani, Francesco; Hernandez, Miguel; Villà-Freixa, Jordi; Losko, Sascha

2011-03-05

To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow predictive hypotheses to be defined. Life science has become a data rich science with information about the behaviour of millions of entities like genes, chemical compounds, diseases, cell types and organs, which are organised in many different databases and/or spread throughout the literature. Existing knowledge such as genotype-phenotype relations or signal transduction pathways must be semantically integrated and dynamically organised into structured networks that are connected with clinical and experimental data. Different approaches to this challenge exist but so far none has proven entirely satisfactory. To address this challenge we previously developed a generic knowledge management framework, BioXM™, which allows the dynamic, graphic generation of domain specific knowledge representation models based on specific objects and their relations supporting annotations and ontologies. Here we demonstrate the utility of BioXM for knowledge management in systems biology as part of the EU FP6 BioBridge project on translational approaches to chronic diseases. From clinical and experimental data, text-mining results and public databases we generate a chronic obstructive pulmonary disease (COPD) knowledge base and demonstrate its use by mining specific molecular networks together with integrated clinical and experimental data. We generate the first semantically integrated COPD specific public knowledge base and find that for the integration of clinical and experimental data with pre-existing knowledge the configuration based set-up enabled by BioXM reduced implementation time and effort for the knowledge base compared to similar systems implemented as classical software development projects. The knowledgebase enables the retrieval of sub-networks including protein-protein interaction, pathway, gene--disease and gene--compound data which are used for subsequent data analysis, modelling and simulation. Pre-structured queries and reports enhance usability; establishing their use in everyday clinical settings requires further simplification with a browser based interface which is currently under development.

Knowledge management for systems biology a general and visually driven framework applied to translational medicine

PubMed Central

2011-01-01

Background To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow predictive hypotheses to be defined. Life science has become a data rich science with information about the behaviour of millions of entities like genes, chemical compounds, diseases, cell types and organs, which are organised in many different databases and/or spread throughout the literature. Existing knowledge such as genotype - phenotype relations or signal transduction pathways must be semantically integrated and dynamically organised into structured networks that are connected with clinical and experimental data. Different approaches to this challenge exist but so far none has proven entirely satisfactory. Results To address this challenge we previously developed a generic knowledge management framework, BioXM™, which allows the dynamic, graphic generation of domain specific knowledge representation models based on specific objects and their relations supporting annotations and ontologies. Here we demonstrate the utility of BioXM for knowledge management in systems biology as part of the EU FP6 BioBridge project on translational approaches to chronic diseases. From clinical and experimental data, text-mining results and public databases we generate a chronic obstructive pulmonary disease (COPD) knowledge base and demonstrate its use by mining specific molecular networks together with integrated clinical and experimental data. Conclusions We generate the first semantically integrated COPD specific public knowledge base and find that for the integration of clinical and experimental data with pre-existing knowledge the configuration based set-up enabled by BioXM reduced implementation time and effort for the knowledge base compared to similar systems implemented as classical software development projects. The knowledgebase enables the retrieval of sub-networks including protein-protein interaction, pathway, gene - disease and gene - compound data which are used for subsequent data analysis, modelling and simulation. Pre-structured queries and reports enhance usability; establishing their use in everyday clinical settings requires further simplification with a browser based interface which is currently under development. PMID:21375767

An integrated multi-sensors approach for volcanic cloud retrievals and source characterization

NASA Astrophysics Data System (ADS)

Corradini, Stefano; Merucci, Luca

2017-04-01

Volcanic eruptions are one the most important sources of natural pollution. In particular the volcanic clouds represent a severe threat for aviation safety. Worldwide the volcanic activity is monitored by using satellite and ground-based instruments working at different spectral ranges, with different spatial resolutions and sensitivities. Here the complementarity between geostationary and polar satellites and ground based measurements is exploited, in order to significantly improve the volcanic cloud detection and retrievals and to fully characterize the eruption source. The integration procedure named MACE (Multi-platform volcanic Ash Cloud Estimation), has been developed during the EU-FP7 APhoRISM project aimed to develop innovative products to support the management and mitigation of the volcanic and the seismic crisis. The proposed method integrates in a novel manner the volcanic ash retrievals at the space-time scale of typical geostationary observations using both the polar satellite estimations and in-situ measurements. On MACE the typical volcanic cloud retrievals in the thermal infrared are integrated by using a wider spectral range from visible to microwave. Moreover the volcanic cloud detection is extended in case of cloudy atmosphere or steam plumes. As example, the integrated approach is tested on different recent eruptions, occurred on Etna (Italy) in 2013 and 2015 and on Calbuco (Chile) in 2015.

ISTIMES Integrated System for Transport Infrastructures Surveillance and Monitoring by Electromagnetic Sensing

NASA Astrophysics Data System (ADS)

Argenti, M.; Giannini, V.; Averty, R.; Bigagli, L.; Dumoulin, J.

2012-04-01

The EC FP7 ISTIMES project has the goal of realizing an ICT-based system exploiting distributed and local sensors for non destructive electromagnetic monitoring in order to make critical transport infrastructures more reliable and safe. Higher situation awareness thanks to real time and detailed information and images of the controlled infrastructure status allows improving decision capabilities for emergency management stakeholders. Web-enabled sensors and a service-oriented approach are used as core of the architecture providing a sys-tem that adopts open standards (e.g. OGC SWE, OGC CSW etc.) and makes efforts to achieve full interoperability with other GMES and European Spatial Data Infrastructure initiatives as well as compliance with INSPIRE. The system exploits an open easily scalable network architecture to accommodate a wide range of sensors integrated with a set of tools for handling, analyzing and processing large data volumes from different organizations with different data models. Situation Awareness tools are also integrated in the system. Definition of sensor observations and services follows a metadata model based on the ISO 19115 Core set of metadata elements and the O&M model of OGC SWE. The ISTIMES infrastructure is based on an e-Infrastructure for geospatial data sharing, with a Data Cata-log that implements the discovery services for sensor data retrieval, acting as a broker through static connections based on standard SOS and WNS interfaces; a Decision Support component which helps decision makers providing support for data fusion and inference and generation of situation indexes; a Presentation component which implements system-users interaction services for information publication and rendering, by means of a WEB Portal using SOA design principles; A security framework using Shibboleth open source middleware based on the Security Assertion Markup Language supporting Single Sign On (SSO). ACKNOWLEDGEMENT - The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under Grant Agreement n° 225663

Costs can influence family planning decisions.

PubMed

Barnett, B

1998-01-01

This article discusses research in Cebu, Philippines, that examines the relationship between costs and income and family planning (FP) decisions. Clients weigh the costs and benefits of obtaining FP services. Costs may include the time to purchase supplies, travel to clinics, child care, and lost work time. Women should consider the costs of having more children. Family Health International's Women's Studies Project explored couple's FP decision-making. In Cebu, women play a decisive role in household expenditure decisions. 64% of women made sole decisions about children's shoes and clothing. 43% made decisions about taking children to the doctor. Women consulted husbands for larger expenditures, such as land purchases, hiring household help, and travel outside Cebu. If conflicts arose, 82% reported a mutual final decision, while 12% accepted the husband's judgment. Only 12% of women made sole decisions about FP. About 20% of the sample of women discussed FP with adult females. 25% of the women who consulted their husbands about FP made the final decision when there was conflict. Only 7% reported that the husband's decision was final. A recent follow-up study to a 1983 study finds that price is only one among many factors that affect contraceptive decision-making. Rural women in Cebu reported that the time needed to obtain contraceptives was an important factor in determining their use. A study of 64 women in rural southern India finds that contraceptive prevalence was influenced by women's autonomy rather than income. Women's and children's ages, family size, and birth order affected women's autonomy and access to money. In another related study, Pakistani women had lower fertility rates when wives' unearned income was high. An increase by 25% in unearned income among rural women decreased fertility by one child.

Litter dynamics in two Sierran mixed conifer forests. I. Litterfall and decomposition rates

USGS Publications Warehouse

Stohlgren, Thomas J.

1988-01-01

Litterfall was measured for 4 years and leaf litter decomposition rates were studied for 3.6 years in two mixed conifer forest (giant sequoia-fir and fir-pine) in the southern Sierra Nevada of California. The giant sequoia-fir forest (GS site) was dominated by giant sequoia (Sequoiadendron giganteum (Lindl.) Buchh.), white fir (Abies concolor Lindl. & Gord.), and sugar pine (Pinus lambertiana Dougl.). The fir-pine forest (FP site) was dominated by white fir, sugar pine, and incense cedar (Calocedrus decurrens (Torr.) Florin). Litterfall, including large woody debris -1•year-1 compared with 4355 kg•ha-1•year-1 at the FP site (3.4:1). In the GS site, leaf litter decomposition after 3.6 years was slowest for giant sequoia (28.2% mass loss), followed by sugar pine (34.3%) and white fie (45.1%). In the FP site, mass loss was slowest for sugar pine (40.0%), followed by white fir (45.1%), while incense cedar showed the greatest mass loss (56.9%) after 3.6 years. High litterfall rates of large woody debris (i.e., 2.5-15.2 cm diameter) and slow rates of leaf litter decomposition in the giant sequoia-fir forest type may result in higher litter accumulation rates than in the fir-pine type. Leaf litter times to 95% decay for the GS and FP sites were 30 and 27 years, respectively, if the initial 0.7-year period (a short period of rapid mass decay) was ignored in the calculation. A mass balance approach for total litterfall (<15.2 cm diameter) decomposition yielded lower decay constants than did the litterbag study and therefore longer times to 95% decay (57 years for the GS site and 62 years for the FP site).

Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study.

PubMed

Iranzo, Alex; Valldeoriola, Francesc; Lomeña, Francisco; Molinuevo, José Luis; Serradell, Mónica; Salamero, Manel; Cot, Albert; Ros, Domènec; Pavía, Javier; Santamaria, Joan; Tolosa, Eduardo

2011-09-01

Serial dopamine transporter (DAT) imaging in patients with Parkinson's disease (PD) and other synucleinopathies shows progressive nigrostriatal dopaminergic dysfunction. Because idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can precede the classic symptoms of PD and other synucleinopathies, we postulated that serial DAT imaging in patients with IRBD could be used to detect decline in striatal tracer uptake, indicating progressive nigrostriatal cell degeneration. In a prospective study, 20 patients with IRBD (mean age 70·55 years [SD 6·02]) underwent serial DAT imaging with (123)I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane ((123)I-FP-CIT) SPECT at baseline and again after 1·5 years and 3 years; 20 age-matched and sex-matched control participants (69·50 years [6·77]) underwent imaging at baseline and 3 years. The striatum to occipital cortex uptake ratios were calculated for the putamen and caudate nucleus in each hemisphere. In patients, the ratio was judged to be reduced when it was less than two SD of the mean ratio in controls at the same timepoint. Differences in (123)I-FP-CIT uptake between patients and controls in each striatal region and rates of decline were assessed by use of multivariate ANOVA (MANOVA). Compared with controls, patients had significantly reduced mean (123)I-FP-CIT binding in all four striatal regions at baseline and after 3 years. Striatal (123)I-FP-CIT uptake was reduced compared with that in controls in ten patients at baseline and in 13 patients after 3 years. In patients, the mean reduction in (123)I-FP-CIT uptake from baseline to 3 years was 19·36% (95% CI 15·14 to 23·59) in the left putamen, 15·57% (10·87 to 20·28) in the right putamen, 10·81% (6·49 to 15·18) in the left caudate nucleus, and 7·14% (2·74 to 11·56) in the right caudate nucleus. After adjustment for the baseline (123)I-FP-CIT uptake ratios, the decline in (123)I-FP-CIT binding at baseline to 3 years was significantly greater in patients than in controls in the left putamen (9·78% difference between groups, 95% CI 3·22 to 16·32), right putamen (5·43%, 1·99 to 12·86), and left caudate nucleus (8·07%, 1·44 to 14·70), but not in the right caudate nucleus (4·16%, -3·00 to 11·34). At the 3-year assessment, three patients were diagnosed with PD. These patients had the lowest (123)I-FP-CIT uptake at baseline and a mean reduction in (123)I-FP-CIT uptake at 3 years of 32·81% in the left putamen, 30·40% in the right putamen, 26·51% in the left caudate nucleus, and 23·75% in the right caudate nucleus. In patients with IRBD, serial (123)I-FP-CIT SPECT shows decline in striatal tracer uptake that reflects progressive nigrostriatal dopaminergic dysfunction. Serial (123)I-FP-CIT SPECT can be used to monitor the progression of nigrostriatal deficits in patients with IRBD, and could be useful in studies of potential disease-modifying compounds in these patients. Fondo de Investigaciones Sanitarias of Spain. Copyright © 2011 Elsevier Ltd. All rights reserved.

How are we doing? Evaluation as part of sexuality education.

PubMed

Brick, P

1997-01-01

In 1986, Planned Parenthood of Greater Northern New Jersey (PPGNNJ) began to evaluate its sex education programs. First PPGNNJ staff evaluated a 1-day, 40-minute lesson designed to help high school students 1) identify risk behavior for unplanned pregnancy, 2) estimate risk, and 3) review basic contraceptive methods. This project showed that a single lesson could substantially increase knowledge about contraception and comfort with the idea of condoms and family planning (FP) clinic use. A second PPGNNJ evaluation project revealed that adding a motivational video to the lesson increased the feeling of comfort expressed about use of an FP clinic and that PPGNNJ staff were more effective than regular teachers in promoting change in attitudes about FP services, but teachers were more effective in promoting longterm knowledge of risk. Evaluation of five popular AIDS prevention videos revealed that all of the videos significantly increased HIV/AIDS knowledge and motivation to seek protection. However, the videos made many viewers feel helpless about their ability to protect themselves and unwilling to support an AIDS home in their neighborhood. PPGNNJ's staff also designed the "Human Sexuality Questionnaire" to determine the impact of a five-session sex education program delivered to high-risk youth. This tool is now used in program evaluation nationwide. Evaluation of two date rape prevention strategies (a single-lesson, interactive date-rape scenario and a video) revealed a significant impact on females and none on males. Testing of a 1994 video and discussion session designed to improve adolescent attitudes towards use of an FP clinic also had positive results. While these evaluation methodologies were not problem-free, evaluation forced PPGNNJ staff to define objectives and lessons, enter a new collaboration with schools, and use results to continually evaluate work.

Economic losses to buildings due to tsunami impact: the case of Rhodes city, Greece

NASA Astrophysics Data System (ADS)

Triantafyllou, Ioanna; Novikova, Tatyana; Papadopoulos, Gerassimos

2017-04-01

The expected economic losses to buildings due to the tsunami impact is of particular importance for the tsunami risk management. However, only few efforts can be found in this direction. In this study we approached this issue selecting the city of Rhodes Isl., Greece, as a test-site. The methodological steps followed include (a) selection of worst case scenario in the study area based on the tsunami history of the area which includes several powerful events, e.g. 142 AD, 1303, 1481, 1609, 1741, (b) numerical simulation of the tsunami and determination of the inundation zone, (c) application of the DAMASCHE empirical tool, produced by the SCHEMA EU-FP6 project, for the calculation of the damage level expected at each one of the buildings as a function of the water depth in the inundation area, (d) calculation of the buildings that would need reparation after partial damage and of those that would need reconstruction after total destruction, (e) calculation of the cost implied for both reparation and reconstruction. The several data sets which are needed for the execution of these steps, are susceptible to uncertainties and, therefore, the final results are quite sensitive to changes of the data sets. Alternative costs were calculated by taking into account the several uncertainties involved. This research is a contribution to the EU-FP7 tsunami research project ASTARTE (Assessment, Strategy And Risk Reduction for Tsunamis in Europe), grant agreement no: 603839, 2013-10-30.

Recognition of lesion correspondence on two mammographic views: a new method of false-positive reduction for computerized mass detection

NASA Astrophysics Data System (ADS)

Sahiner, Berkman; Petrick, Nicholas; Chan, Heang-Ping; Paquerault, Sophie; Helvie, Mark A.; Hadjiiski, Lubomir M.

2001-07-01

We used the correspondence of detected structures on two views of the same breast for false-positive (FP) reduction in computerized detection of mammographic masses. For each initially detected object on one view, we considered all possible pairings with objects on the other view that fell within a radial band defined by the nipple-to-object distances. We designed a 'correspondence classifier' to classify these pairs as either the same mass (a TP-TP pair) or a mismatch (a TP-FP, FP-TP or FP-FP pair). For each pair, similarity measures of morphological and texture features were derived and used as input features in the correspondence classifier. Two-view mammograms from 94 cases were used as a preliminary data set. Initial detection provided 6.3 FPs/image at 96% sensitivity. Further FP reduction in single view resulted in 1.9 FPs/image at 80% sensitivity and 1.1 FPs/image at 70% sensitivity. By combining single-view detection with the correspondence classifier, detection accuracy improved to 1.5 FPs/image at 80% sensitivity and 0.7 FPs/image at 70% sensitivity. Our preliminary results indicate that the correspondence of geometric, morphological, and textural features of a mass on two different views provides valuable additional information for reducing FPs.

Impact of family planning health talks by lay health workers on contraceptive knowledge and attitudes among HIV-infected patients in rural Kenya

PubMed Central

Onono, Maricianah; Blat, Cinthia; Miles, Sondra; Steinfeld, Rachel; Wekesa, Pauline; Bukusi, Elizabeth A.; Owuor, Kevin; Grossman, Daniel; Cohen, Craig R.; Newmann, Sara J.

2015-01-01

Objective To determine if a health talk on family planning (FP) by community clinic health assistants (CCHAs) will improve knowledge, attitudes and behavioral intentions about contraception in HIV-infected individuals. Methods A 15-min FP health talk was given by CCHAs in six rural HIV clinics to a sample of 49 HIV-infected men and women. Effects of the health talk were assessed through a questionnaire administered before the health talk and after completion of the participant's clinic visit. Results Following the health talk, there was a significant increase in knowledge about contraceptives (p < .0001), side-effects (p < .0001), and method-specific knowledge about IUCDs (p < .001), implants (p < .0001), and injectables (p < .05). Out of 31 women and 18 men enrolled, 14 (45%) women and 6 (33%) men intended to try a new contraceptive. Participant attitudes toward FP were high before and after the health talk (median 4 of 4). Conclusion A health talk delivered by CCHAs can increase knowledge of contraception and promote the intention to try new more effective contraception among HIV-infected individuals. Practice implications FP health talks administered by lay-health providers to HIV-infected individuals as they wait for HIV services can influence FP knowledge and intention to use FP. PMID:24316053

Impact of family planning health talks by lay health workers on contraceptive knowledge and attitudes among HIV-infected patients in rural Kenya.

PubMed

Onono, Maricianah; Blat, Cinthia; Miles, Sondra; Steinfeld, Rachel; Wekesa, Pauline; Bukusi, Elizabeth A; Owuor, Kevin; Grossman, Daniel; Cohen, Craig R; Newmann, Sara J

2014-03-01

To determine if a health talk on family planning (FP) by community clinic health assistants (CCHAs) will improve knowledge, attitudes and behavioral intentions about contraception in HIV-infected individuals. A 15-min FP health talk was given by CCHAs in six rural HIV clinics to a sample of 49 HIV-infected men and women. Effects of the health talk were assessed through a questionnaire administered before the health talk and after completion of the participant's clinic visit. Following the health talk, there was a significant increase in knowledge about contraceptives (p<.0001), side-effects (p<.0001), and method-specific knowledge about IUCDs (p<.001), implants (p<.0001), and injectables (p<.05). Out of 31 women and 18 men enrolled, 14 (45%) women and 6 (33%) men intended to try a new contraceptive. Participant attitudes toward FP were high before and after the health talk (median 4 of 4). A health talk delivered by CCHAs can increase knowledge of contraception and promote the intention to try new more effective contraception among HIV-infected individuals. FP health talks administered by lay-health providers to HIV-infected individuals as they wait for HIV services can influence FP knowledge and intention to use FP. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Ratiometric Matryoshka biosensors from a nested cassette of green- and orange-emitting fluorescent proteins.

PubMed

Ast, Cindy; Foret, Jessica; Oltrogge, Luke M; De Michele, Roberto; Kleist, Thomas J; Ho, Cheng-Hsun; Frommer, Wolf B

2017-09-05

Sensitivity, dynamic and detection range as well as exclusion of expression and instrumental artifacts are critical for the quantitation of data obtained with fluorescent protein (FP)-based biosensors in vivo. Current biosensors designs are, in general, unable to simultaneously meet all these criteria. Here, we describe a generalizable platform to create dual-FP biosensors with large dynamic ranges by employing a single FP-cassette, named GO-(Green-Orange) Matryoshka. The cassette nests a stable reference FP (large Stokes shift LSSmOrange) within a reporter FP (circularly permuted green FP). GO- Matryoshka yields green and orange fluorescence upon blue excitation. As proof of concept, we converted existing, single-emission biosensors into a series of ratiometric calcium sensors (MatryoshCaMP6s) and ammonium transport activity sensors (AmTryoshka1;3). We additionally identified the internal acid-base equilibrium as a key determinant of the GCaMP dynamic range. Matryoshka technology promises flexibility in the design of a wide spectrum of ratiometric biosensors and expanded in vivo applications.Single fluorescent protein biosensors are susceptible to expression and instrumental artifacts. Here Ast et al. describe a dual fluorescent protein design whereby a reference fluorescent protein is nested within a reporter fluorescent protein to control for such artifacts while preserving sensitivity and dynamic range.

The impact of individual variations in taste sensitivity on coffee perceptions and preferences.

PubMed

Masi, Camilla; Dinnella, Caterina; Monteleone, Erminio; Prescott, John

2015-01-01

Despite a few relationships between fungiform papillae (FP) density and 6-n-propylthiouracil (PROP) taster status have been reported for sensory qualities within foods, the impact on preferences remains relatively unclear. The present study investigated responses of FP number and PROP taster groups to different bitter compounds and how these affect coffee perception, consumption and liking. Subjects (Ss) with higher FP numbers (HFP) gave higher liking ratings to coffee samples than those with lower FP numbers (LFP), but only for sweetened coffee. Moreover, HFP Ss added more sugar to the samples than LFP Ss. Significant differences between FP groups were also found for the sourness of the coffee samples, but not for bitterness and astringency. However, HFP Ss rated bitter taste stimuli as stronger than did LFP Ss. While coffee liking was unrelated to PROP status, PROP non-tasters (NTs) added more sugar to the coffee samples than did super-tasters (STs). In addition, STs rated sourness, bitterness and astringency as stronger than NTs, both in coffee and standard solutions. These results confirm that FP density and PROP status play a significant role in taste sensitivity for bitter compounds in general and also demonstrate that sugar use is partly a function of fundamental individual differences in physiology. Copyright © 2014 Elsevier Inc. All rights reserved.

Genetically-encoded fluorescent voltage sensors using the voltage-sensing domain of Nematostella and Danio phosphatases exhibit fast kinetics

PubMed Central

Baker, Bradley J.; Jin, Lei; Han, Zhou; Cohen, Lawrence B.; Popovic, Marko; Platisa, Jelena; Pieribone, Vincent

2012-01-01

A substantial increase in the speed of the optical response of genetically-encoded Fluorescent Protein voltage sensors (FP voltage sensors) was achieved by using the voltage-sensing phosphatase genes of Nematostella vectensis and Danio rerio. A potential N. vectensis voltage-sensing phosphatase was identified in silico. The voltage-sensing domain (S1–S4) of the N. vectensis homolog was used to create an FP voltage sensor called Nema. By replacing the phosphatase with a cerulean/citrine FRET pair, a new FP voltage sensor was synthesized with fast off kinetics (Tauoff <5 msec). However, the signal was small (ΔF/F= 0.6%/200 mV). FP voltage sensors using the D. rerio voltage-sensing phosphatase homolog, designated Zahra and Zahra 2, exhibited fast on and off kinetics within 2 msec of the time constants observed with the organic voltage-sensitive dye, di4-ANEPPS. Mutagenesis of the S4 region of the Danio FP voltage sensor shifted the voltage dependence to more negative potentials but did not noticeably affect the kinetics of the optical signal. PMID:22634212

A Descriptive Evaluation of Software Sizing Models

DTIC Science & Technology

1987-09-01

2-22 2.3.2 SPQR Sizer/FP ............................... 2-25 2.3.3 QSM Size Planner: Function Points .......... 2-26 2.3.4 Feature...Characteristics ............................. 4-20 4.5.3 Results and Conclusions ..................... 4-20 4.6 Application of the SPQR SIZER/FP Approach...4-19 4-7 SPQR Function Point Estimate for the CATSS Sensitivity Model .................................................. 4-23 4-8 ASSET-R

A project for women, by women.

PubMed

1995-11-01

The Integrated Family Development Project (IFDP), which was initiated in 1993, is a successful project for women, by women, in Bangladesh. It is implemented by the Family Planning Association of Bangladesh (FPAB), with the support of JOICFP. The project falls under the regional Sustainable Community-Based Family Planning/Maternal and Child Health (FP/MCH) Project with Special Focus on Women, which is funded by the United Nations Population Fund (UNFPA). The project focuses on women's empowerment; promotion of reproductive health, including family planning; and promotion of education and economic activities for women. Small libraries have been established at project centers in Panchdona Union of Narsingdi District and Dhalia Union of Feni District. The books provide women with practical information on subjects such as children's nutrition, health, and lifestyles. Loans provided under the project have stimulated the formation of women's work teams for income generating projects (mat making, goat raising, pottery making, weaving, and sewing). 24 women, who were recruited from their villages, have been trained as development volunteers (FDVs) in each of the two unions; they serve as health and education agents who deliver services, including family planning, to women and promote health care in their communities. Evaluations have been positive, and surrounding villages are beginning similar activities. Funds, which were allocated under the Postal Savings for International Voluntary Aid (POSIVA) and administered by the Japanese Ministry of Posts and Telecommunications, have been used for medical equipment, IEC supplies and equipment, and transportation equipment.

High-resolution motion compensated MRA in patients with congenital heart disease using extracellular contrast agent at 3 Tesla.

PubMed

Dabir, Darius; Naehle, Claas Philip; Clauberg, Ralf; Gieseke, Juergen; Schild, Hans H; Thomas, Daniel

2012-10-29

Using first-pass MRA (FP-MRA) spatial resolution is limited by breath-hold duration. In addition, image quality may be hampered by respiratory and cardiac motion artefacts. In order to overcome these limitations an ECG- and navigator-gated high-resolution-MRA sequence (HR-MRA) with slow infusion of extracellular contrast agent was implemented at 3 Tesla for the assessment of congenital heart disease and compared to standard first-pass-MRA (FP-MRA). 34 patients (median age: 13 years) with congenital heart disease (CHD) were prospectively examined on a 3 Tesla system. The CMR-protocol comprised functional imaging, FP- and HR-MRA, and viability imaging. After the acquisition of the FP-MRA sequence using a single dose of extracellular contrast agent the motion compensated HR-MRA sequence with isotropic resolution was acquired while injecting the second single dose, utilizing the timeframe before viability imaging. Qualitative scores for image quality (two independent reviewers) as well as quantitative measurements of vessel sharpness and relative contrast were compared using the Wilcoxon signed-rank test. Quantitative measurements of vessel diameters were compared using the Bland-Altman test. The mean image quality score revealed significantly better image quality of the HR-MRA sequence compared to the FP-MRA sequence in all vessels of interest (ascending aorta (AA), left pulmonary artery (LPA), left superior pulmonary vein (LSPV), coronary sinus (CS), and coronary ostia (CO); all p < 0.0001). In comparison to FP-MRA, HR-MRA revealed significantly better vessel sharpness for all considered vessels (AA, LSPV and LPA; all p < 0.0001). The relative contrast of the HR-MRA sequence was less compared to the FP-MRA sequence (AA: p <0.028, main pulmonary artery: p <0.004, LSPV: p <0.005). Both, the results of the intra- and interobserver measurements of the vessel diameters revealed closer correlation and closer 95 % limits of agreement for the HR-MRA. HR-MRA revealed one additional clinical finding, missed by FP-MRA. An ECG- and navigator-gated HR-MRA-protocol with infusion of extracellular contrast agent at 3 Tesla is feasible. HR-MRA delivers significantly better image quality and vessel sharpness compared to FP-MRA. It may be integrated into a standard CMR-protocol for patients with CHD without the need for additional contrast agent injection and without any additional examination time.

Non-Mydriatic Fundus Retinography in Screening for Diabetic Retinopathy: Agreement Between Family Physicians, General Ophthalmologists, and a Retinal Specialist.

PubMed

Cunha, Leonardo Provetti; Figueiredo, Evelyn Alvernaz; Araújo, Henrique Pereira; Costa-Cunha, Luciana Virgínia Ferreira; Costa, Carolina Ferreira; Neto, José de Melo Costa; Matos, Aline Mota Freitas; de Oliveira, Marise Machado; Bastos, Marcus Gomes; Monteiro, Mário Luiz Ribeiro

2018-01-01

To determine the level of agreement between trained family physicians (FPs), general ophthalmologists (GOs), and a retinal specialist (RS) in the assessment of non-mydriatic fundus retinography in screening for diabetic retinopathy (DR) in the primary health-care setting. 200 Diabetic patients were submitted to two-field non-mydriatic digital fundus camera. The images were examined by four trained FPs, two GOs, and one RS with regard to the diagnosis and severity of DR and the diagnosis of macular edema. The RS served as gold standard. Reliability and accuracy were determined with the kappa test and diagnostic measures. A total of 397 eyes of 200 patients were included. The mean age was 55.1 (±11.7) years, and 182 (91%) had type 2 diabetes. The mean levels of serum glucose and glycosylated hemoglobin A1c were 195.6 (±87.3) mg/dL and 8.9% (±2.1), respectively. DR was diagnosed in 166 eyes by the RS and in 114 and 182 eyes by GO 1 and GO 2 , respectively. For severity, DR was graded as proliferative in 8 eyes by the RS vs. 15 and 9 eyes by GO 1 and GO 2 , respectively. The agreement between the RS and the GOs was substantial for both DR diagnosis (GO 1 k  = 0.65; GO 2 k  = 0.74) and severity (GO 1 k  = 0.60; GO 2 k  = 0.71), and fair or moderate for macular edema (GO 1 k  = 0.27; GO 2 k  = 0.43). FP 1 , FP 2 , FP 3 , and FP 4 diagnosed DR in 108, 119, 163, and 117 eyes, respectively. The agreement between the RS and the FPs with regard to DR diagnosis was substantial (FP 2 k  = 0.69; FP 3 k  = 0.73; FP 4 k  = 0.71) or moderate (FP 1 k  = 0.56). As for DR severity, the agreement between the FPs and the RS was substantial (FP 2 k  = 0.66; FP 3 k  = 069; FP 4 k  = 0.64) or moderate (FP 1 k  = 0.51). Agreement between the FPs and the RS with regard to macular edema was fair (FP 1 k  = 0.33; FP 2 k  = 0.39; FP 3 k  = 0.37) or moderate (FP 4 k  = 0.51). Non-mydriatic fundus retinography was shown to be useful in DR screening in the primary health-care setting. FPs made assessments with good levels of agreement with an RS. Non-mydriatic fundus retinography associated with appropriate general physicians training is essential for the DR screening.

Care outcomes in long-term care facilities in British Columbia, Canada. Does ownership matter?

PubMed

McGregor, Margaret J; Tate, Robert B; McGrail, Kimberlyn M; Ronald, Lisa A; Broemeling, Anne-Marie; Cohen, Marcy

2006-10-01

This study investigated whether for-profit (FP) versus not-for-profit (NP) ownership of long-term care facilities resulted in a difference in hospital admission and mortality rates among facility residents in British Columbia, Canada. This retrospective cohort study used administrative data on all residents of British Columbia long-term care facilities between April 1, 1996, and August 1, 1999 (n = 43,065). Hospitalizations were examined for 6 diagnoses (falls, pneumonia, anemia, dehydration, urinary tract infection, and decubitus ulcers and/or gangrene), which are considered to be reflective of facility quality of care. In addition to FP versus NP status, facilities were divided into ownership subgroups to investigate outcomes by differences in governance and operational structures. We found that, overall, FP facilities demonstrated higher adjusted hospitalization rates for pneumonia, anemia, and dehydration and no difference for falls, urinary tract infections, or DCU/gangrene. FP facilities demonstrated higher adjusted hospitalization rates compared with NP facilities attached to a hospital, amalgamated to a regional health authority, or that were multisite. This effect was not present when comparing FP facilities to NP single-site facilities. There was no difference in mortality rates in FP versus NP facilities. The higher adjusted hospitalization rates in FP versus NP facilities is consistent with previous research from U.S. authors. However, the superior performance by the NP sector is driven by NP-owned facilities connected to a hospital or health authority, or that had more than one site of operation.

Highly Efficient Multiple-Anchored Fluorescent Probe for the Detection of Aniline Vapor Based on Synergistic Effect: Chemical Reaction and PET.

PubMed

Jiao, Zinuo; Zhang, Yu; Xu, Wei; Zhang, Xiangtao; Jiang, Haibo; Wu, Pengcheng; Fu, Yanyan; He, Qingguo; Cao, Huimin; Cheng, Jiangong

2017-05-26

A multiple-anchored fluorescent probe ((((hexane-1,6-diylbis(2,7-bis(4-formyl)-phenyl)-9H-fluorine-9,9-diyl))-bis(hexane-6,1-diyl))-bis(9H-carbazole-9,3,6-triyl))-tetrakis(benzene-4,1-diyl))-tetraformyl-(8FP-2F) with eight aldehyde groups was designed and synthesized. The molecule has four branches and highly twisted structure. Furthermore, it tends to self-assemble into nanospheres, which is beneficial for gaseous analyte penetration and high fluorescence quantum efficiency. Among gaseous analytes, detection of aniline vapor is extraordinarily important in the control of environmental issues and human diseases. Herein, 8FP-2F was introduced to detect aniline vapor with distinguished sensitivity and selectivity via simple Schiff base reaction at room temperature. After exposure to saturate aniline vapor, the 89% fluorescence of 8FP-2F was quenched in 50 s and the detection limit was as low as 3 ppb. Further study showed the suitable HOMO/LUMO energy levels and matched orbital symmetry between probe and aniline molecules ensured chemical reaction and PET process work together. The synergistic effect resulted in a significant sensing performance and fluorescence quenching toward aniline vapor. Moreover, the multiple active sites structure of 8FP-2F means it could be applied for constructing many interesting structures and highly efficient organic optoelectronic functional materials.

Measurement of sodium concentration in sweat samples: comparison of 5 analytical techniques.

PubMed

Goulet, Eric D B; Asselin, Audrey; Gosselin, Jonathan; Baker, Lindsay B

2017-08-01

Sweat sodium concentration (SSC) can be determined using different analytical techniques (ATs), which may have implications for athletes and scientists. This study compared the SSC measured with 5 ATs: ion chromatography (IChr), flame photometry (FP), direct (DISE) and indirect (IISE) ion-selective electrode, and ion conductivity (IC). Seventy sweat samples collected from 14 athletes were analyzed with 5 instruments: the 883 Basic IC Plus (IChr, reference instrument), AAnalyst 200 (FP), Cobas 6000 (IISE), Sweat-Chek (IC), and B-722 Laqua Twin (DISE). Instruments showed excellent relative (intraclass correlation coefficient (ICC) ≥ 0.999) and absolute (coefficient of variation (CV) ≤ 2.6%) reliability. Relative validity was also excellent between ATs (ICC ≥ 0.961). In regards to the inter-AT absolute validity, compared with IChr, standard error of the estimates were similar among ATs (2.8-3.8 mmol/L), but CV was lowest with DISE (3.9%), intermediate with IISE (7.6%), and FP (6.9%) and highest with IC (12.3%). In conclusion, SSC varies depending on the AT used to analyze samples. Therefore, results obtained from different ATs are scarcely comparable and should not be used interchangeably. Nevertheless, taking into account the normal variability in SSC (∼±12%), the imprecision of the recommendations deriving from FP, IISE, IC, and DISE should have trivial health and physiological consequences under most exercise circumstances.

Unification and Enhancement of Planetary Robotic Vision Ground Processing: The EC FP7 Project PRoVisG

NASA Astrophysics Data System (ADS)

Paar, G.

2009-04-01

At present, mainly the US have realized planetary space missions with essential robotics background. Joining institutions, companies and universities from different established groups in Europe and two relevant players from the US, the EC FP7 Project PRoVisG started in autumn 2008 to demonstrate the European ability of realizing high-level processing of robotic vision image products from the surface of planetary bodies. PRoVisG will build a unified European framework for Robotic Vision Ground Processing. State-of-art computer vision technology will be collected inside and outside Europe to better exploit the image data gathered during past, present and future robotic space missions to the Moon and the Planets. This will lead to a significant enhancement of the scientific, technologic and educational outcome of such missions. We report on the main PRoVisG objectives and the development status: - Past, present and future planetary robotic mission profiles are analysed in terms of existing solutions and requirements for vision processing - The generic processing chain is based on unified vision sensor descriptions and processing interfaces. Processing components available at the PRoVisG Consortium Partners will be completed by and combined with modules collected within the international computer vision community in the form of Announcements of Opportunity (AOs). - A Web GIS is developed to integrate the processing results obtained with data from planetary surfaces into the global planetary context. - Towards the end of the 39 month project period, PRoVisG will address the public by means of a final robotic field test in representative terrain. The European tax payers will be able to monitor the imaging and vision processing in a Mars - similar environment, thus getting an insight into the complexity and methods of processing, the potential and decision making of scientific exploitation of such data and not least the elegancy and beauty of the resulting image products and their visualization. - The educational aspect is addressed by two summer schools towards the end of the project, presenting robotic vision to the students who are future providers of European science and technology, inside and outside the space domain.

Astrobiology Road Mapping (AstRoMap) - A project within FP7 of the European Commission: First results

NASA Astrophysics Data System (ADS)

Gomez-Gomez, Felipe; Capria, Maria Teresa; Palomba, Ernesto; Walter, Nicolas; Rettberg, Petra; Muller, Christian; Horneck, Gerda

AstRoMap (Astrobiology and Planetary Exploration Road Mapping) is a funded project formulated in the 5th Call of the European Commission FP7 framework. The main objectives of the AstRoMap are: 1. Identify the main astrobiology issues to be addressed by Europe in the next decades in relation with space exploration 2. Identify potential mission concepts that would allow addressing these issues 3. Identify the technology developments required to enable these missions 4. Provide a prioritized roadmap integrating science and technology activities as well as ground-based approach 5. Map scientific knowledge related to astrobiology in Europe To reach those objectives, AstRoMap is executed within the following steps: 1. Community consultation. In order to map the European astrobiology landscape and to provide a collaborative networking platform for this community, the AstRoMap project hosts a database of scientists (European and beyond) interested in astrobiology and planetary exploration (see: http://www.astromap.eu/database.html). It reflects the demography and the research and teaching activities of the astrobiology community, as well as their professional profiles and involvement in astrobiology projects. Considering future aspects of astrobiology in Europe, the need for more astrobiology-dedicated funding programmes at the EU level, especially for cross-disciplinary groups, was stressed. This might eventually lead to the creation of a European laboratory of Astrobiology, or even of a European Astrobiology Institute. 2. Workshops organisation. On the basis of the feedbacks from the community consultation, the potential participants and interesting topics are being identified to take part in the following workshops: 1-. Origin of organic compounds, steps to life; 2. Physico-chemical boundary conditions for habitability 3. Biosignatures as facilitating life detection 4. Origin of the Solar system 3. Astrobiology road-mapping. Based on the results and major conclusions elaborated during the workshops, an astrobiology roadmap will be constructed tailored to the European needs and competences. 4. Education and public outreach. Parallel to the workshop and consultation activities, AstRoMap will provide a comprehensive education and outreach programme and disseminate the progress of AstRoMap through its web site (http://www.astromap.eu).

Motion-based nonuniformity correction in DoFP polarimeters

NASA Astrophysics Data System (ADS)

Kumar, Rakesh; Tyo, J. Scott; Ratliff, Bradley M.

2007-09-01

Division of Focal Plane polarimeters (DoFP) operate by integrating an array of micropolarizer elements with a focal plane array. These devices have been investigated for over a decade, and example systems have been built in all regions of the optical spectrum. DoFP devices have the distinct advantage that they are mechanically rugged, inherently temporally synchronized, and optically aligned. They have the concomitant disadvantage that each pixel in the FPA has a different instantaneous field of view (IFOV), meaning that the polarization component measurements that go into estimating the Stokes vector across the image come from four different points in the field. In addition to IFOV errors, microgrid camera systems operating in the LWIR have the additional problem that FPA nonuniformity (NU) noise can be quite severe. The spatial differencing nature of a DoFP system exacerbates the residual NU noise that is remaining after calibration, and is often the largest source of false polarization signatures away from regions where IFOV error dominates. We have recently presented a scene based algorithm that uses frame-to-frame motion to compensate for NU noise in unpolarized IR imagers. In this paper, we have extended that algorithm so that it can be used to compensate for NU noise on a DoFP polarimeter. Furthermore, the additional information provided by the scene motion can be used to significantly reduce the IFOV error. We have found a reduction of IFOV error by a factor of 10 if the scene motion is known exactly. Performance is reduced when the motion must be estimated from the scene, but still shows a marked improvement over static DoFP images.

Shale gas wastewater management under uncertainty.

PubMed

Zhang, Xiaodong; Sun, Alexander Y; Duncan, Ian J

2016-01-01

This work presents an optimization framework for evaluating different wastewater treatment/disposal options for water management during hydraulic fracturing (HF) operations. This framework takes into account both cost-effectiveness and system uncertainty. HF has enabled rapid development of shale gas resources. However, wastewater management has been one of the most contentious and widely publicized issues in shale gas production. The flowback and produced water (known as FP water) generated by HF may pose a serious risk to the surrounding environment and public health because this wastewater usually contains many toxic chemicals and high levels of total dissolved solids (TDS). Various treatment/disposal options are available for FP water management, such as underground injection, hazardous wastewater treatment plants, and/or reuse. In order to cost-effectively plan FP water management practices, including allocating FP water to different options and planning treatment facility capacity expansion, an optimization model named UO-FPW is developed in this study. The UO-FPW model can handle the uncertain information expressed in the form of fuzzy membership functions and probability density functions in the modeling parameters. The UO-FPW model is applied to a representative hypothetical case study to demonstrate its applicability in practice. The modeling results reflect the tradeoffs between economic objective (i.e., minimizing total-system cost) and system reliability (i.e., risk of violating fuzzy and/or random constraints, and meeting FP water treatment/disposal requirements). Using the developed optimization model, decision makers can make and adjust appropriate FP water management strategies through refining the values of feasibility degrees for fuzzy constraints and the probability levels for random constraints if the solutions are not satisfactory. The optimization model can be easily integrated into decision support systems for shale oil/gas lifecycle management. Copyright © 2015 Elsevier Ltd. All rights reserved.

Improved angiogenesis and healing in crush syndrome by fibroblast growth factor-2-containing low-molecular-weight heparin (Fragmin)/protamine nanoparticles.

PubMed

Takikawa, Makoto; Nakamura, Shingo; Ishihara, Masayuki; Takabayashi, Yuki; Fujita, Masanori; Hattori, Hidemi; Kushibiki, Toshihiro; Ishihara, Miya

2015-06-15

We produced fibroblast growth factor (FGF)-2-containing low-molecular-weight heparin (Fragmin)/protamine nanoparticles (FGF-2 + F/P NPs). The purpose of this study was to evaluate the effectiveness of the local administration of FGF-2 + F/P NPs on repairing crush syndrome (CS)-injured lesions after compression release using a nonlethal and reproducible CS injury rat model. The hind limbs of the anesthetized rats were compressed for 6 h using 3.6 kg blocks, as previously described. The effects of administering FGF-2 + F/P NPs (group A), F/P NPs alone (group B), FGF-2 alone (group C), and saline (control; group D) were examined. Motor function, surface blood flow in the hind limbs, and the wet/dry weight ratio in the tibialis anterior muscle were examined for 1-28 d after the compression release. Histologic analyses were also performed. At the middle and late stages (3-28 d after the compression release), group A had higher scores in the motor function, improved blood flow, increased number of blood vessels, and faster recovered muscle tissue, compared with the other groups. There was no significant difference in enhanced edema in the tibialis anterior muscle among all groups. The local administration of FGF-2 + F/P NPs to a CS-injured lesion was effective in repairing damaged muscle tissue after compression release. Copyright © 2015 Elsevier Inc. All rights reserved.

Comparing preseason frontal and sagittal plane plyometric programs on vertical jump height in high-school basketball players.

PubMed

King, Jeffrey A; Cipriani, Daniel J

2010-08-01

The primary purpose of this study was to evaluate whether frontal plane (FP) plyometrics, which are defined as plyometrics dominated with a lateral component, would produce similar increases in vertical jump height (VJH) compared to sagittal plane (SP) Plyometrics. Thirty-two junior varsity and varsity high-school basketball players participated in 6 weeks of plyometric training. Players participated in either FP or SP plyometrics for the entire study. Vertical jump height was measured on 3 occasions: preintervention (baseline), at week 3 of preparatory training, and at week 6 of training. Descriptive statistics were calculated for VJH. A 2-way analysis of variance (ANOVA) with repeated measures was used to test the difference in mean vertical jump scores using FP and SP training modalities. Results showed a significant effect over time for vertical jump (p < 0.001). Moreover, a significant time by protocol interaction was noted (p < 0.032). A 1-way ANOVA demonstrated that only the SP group demonstrated improvements over time, in VJH, p < 0.05. The FP group did not improve statistically. The data from this study suggest that FP plyometric training did not have a significant effect on VJH and significant improvement in VJH was seen in subjects participating in SP plyometrics thus reinforcing the specificity principle of training. However, coaches should implement both types of plyometrics because both training modalities can improve power and quickness among basketball players.

Management tools for R&D engineering projects: Coordination perspective for large international consortium (NeXOS)

NASA Astrophysics Data System (ADS)

Castro, Ayoze; Memè, Simone; Quevedo, Eduardo; Waldmann, Christoph; Pearlman, Jay; Delory, Eric; Llinás, Octavio

2017-04-01

NeXOS is a cross-functional and multidisciplinary project funded under the EU FP7 Program, which involves 21 organizations from six different European countries. They all have different backgrounds, interests, business models and perspectives. To be successful, NeXOS applied an international recognized management methodology tailored to the specific project's environment and conditions, with an explicit structure based on defined roles and responsibilities for the people involved in the project and a means for effective communication between them (Fig.1). The project, divided in four different stages of requirements, design, integration, validation and demonstration, allows a clearer monitor of its progress, a comparison of the level of achievement in accordance with the plan and an earlier detection of problems/issues, leading to implementation of less disruptive, but still effective corrective actions. NeXOS is following an ambitious plan to develop innovative sensor systems with a high degree of modularity and interoperability, starting with requirements definition through validation and demonstration phase. To make this integrative approach possible, a management development strategy has been used incorporating systems engineering methods (Fig.2). Although this is standard practice in software development and large scale systems such as aircraft production, it is still new in the ocean hardware business and therefore NeXOS was a test case for this development concept. The question is one of scale as ocean observation systems are typically built on the scale of a few with co-located teams. With a system of diverse technologies (optical, acoustic, platform interfaces), there are cultural differences that must be bridged. The greatest challenge is in the implementation and the willingness of different teams to work with an engineering process, which may help ultimate system integration, but may place additional burdens on individual participants. This presentation will address approaches for effective operations in this environment.

Engaging with community-based public and private mid-level providers for promoting the use of modern contraceptive methods in rural Pakistan: results from two innovative birth spacing interventions.

PubMed

Azmat, Syed Khurram; Hameed, Waqas; Hamza, Hasan Bin; Mustafa, Ghulam; Ishaque, Muhammad; Abbas, Ghazunfer; Khan, Omar Farooq; Asghar, Jamshaid; Munroe, Erik; Ali, Safdar; Hussain, Wajahat; Ali, Sajid; Ahmed, Aftab; Ali, Moazzam; Temmerman, Marleen

2016-03-17

Family planning (FP) interventions aimed at reducing population growth have negligible during the last two decades in Pakistan. Innovative FP interventions that help reduce the growing population burden are the need of the hour. Marie Stopes Society--Pakistan implemented an operational research project--'Evidence for Innovating to Save Lives', to explore effective and viable intervention models that can promote healthy timing and spacing of pregnancy in rural and under-served communities of Sindh, Punjab and Khyber Pakhtunkhwa provinces of Pakistan. We conducted a quasi-experimental (pre- and post-intervention with control arm) study to assess the effectiveness of each of the two intervention models, (1) Suraj model (meaning 'Sun' in English), which uses social franchises (SF) along with a demand-side financing (DSF) approach using free vouchers, and (2) Community Midwife (CMW) model, in promoting the use of modern contraceptive methods compared to respective controls. Baseline and endline cross-sectional household surveys were conducted, 24 months apart, by recruiting 5566 and 6316 married women of reproductive age (MWRA) respectively. We used Stata version 8 to report the net effect of interventions on outcome indicators using difference-in-differences analysis. Multivariate Cox proportional hazard regression analysis was used to assess the net effect of the intervention on current contraceptive use, keeping time constant and adjusting for other variables in the model. The Suraj model was effective in significantly increasing awareness about FP methods among MWRA by 14% percentage points, current contraceptive use by 5% percentage points and long term modern method--intrauterine device (IUD) use by 6% percentage points. The CMW model significantly increased contraceptive awareness by 28% percentage points, ever use of contraceptives by 7% percentage points and, IUD use by 3% percentage points. Additionally the Suraj intervention led to a 35% greater prevalence (prevalence ratio: 1.35, 95% CI: 1.22-1.50) of contraceptive use among MWRA. Suraj intervention highlights the importance of embedding subsidized FP services within the communities of the beneficiaries. The outcomes of the CMW intervention also improved the use of long-term contraceptives. These findings indicate the necessity of designing and implementing FP initiatives involving local mid-level providers to expand contraceptive coverage in under-served areas.

Mammography Clinical Image Quality and the False Positive Rate in a Canadian Breast Cancer Screening Program.

PubMed

Guertin, Marie-Hélène; Théberge, Isabelle; Zomahoun, Hervé Tchala Vignon; Dufresne, Michel-Pierre; Pelletier, Éric; Brisson, Jacques

2018-05-01

The study sought to determine if mammography quality is associated with the false positive (FP) rate in the Quebec breast cancer screening program in 2004 and 2005. Mammography quality of a random sample of screen-film mammograms was evaluated by an expert radiologist following the criteria of the Canadian Association of Radiologists. For each screening examination, scores ranging from 1 (poor quality) to 5 (excellent quality) were attributed for positioning, compression, contrast, exposure level, sharpness, and artifacts. A final overall quality score (lower or higher) was also given. Poisson regression models with robust estimation of variance and adjusted for potential confounding factors were used to assess associations of mammography quality with the FP rate. Among 1,209 women without cancer, there were 104 (8.6%) FPs. Lower overall mammography quality is associated with an increase in the FP rate (risk ratio [RR], 1.4; 95% confidence interval [CI], 1.0-2.1; P = .07) but this increase was not statistically significant. Artifacts were associated with an increase in the FP rate (RR, 2.1; 95% CI, 1.3-3.3; P = .01) whereas lower quality of exposure level was related to a reduction of the FP rate (RR, 0.4; 95% CI, 0.1-1.0; P = .01). Lower quality scores for all other quality attributes were related to a nonstatistically significant increase in the FP rate of 10%-30%. Artifacts can have a substantial effect on the FP rate. The effect of overall mammography quality on the FP rate may also be substantial and needs to be clarified. Copyright © 2017 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.

A catalogue of the small transients observed in STEREO HI-A and their associated in-situ measurements

NASA Astrophysics Data System (ADS)

Sanchez-Diaz, Eduardo; Rouillard, Alexis P.; Davies, Jackie A.; Kilpua, Emilia; Plotnikov, Illya

2017-04-01

The systematic monitoring of the solar wind in high-cadence and high-resolution heliospheric images taken by the Solar-Terrestrial Relation Observatory (STEREO) spacecraft permits the study of the spatial and temporal evolution of variable solar wind flows from the Sun out to 1 AU, and beyond. As part of the EU Framework 7 (FP7) Heliospheric Cataloguing, Analysis and Techniques Service (HELCATS) project, Plotnikov et al. (2016) created a catalogue of 190 Stream Interaction Regions (SIRs) well-observed in images taken by the Heliospheric Imager (HI) instruments onboard STEREO-A (ST-A). This catalogue has been made available on line on the official HELCATS website (https://www.helcats-fp7.eu/catalogues/wp5_cat.html) and included in the propagation tool (http://propagationtool.cdpp.eu). Several transients, known as blobs, are observed entrained in each SIR. We complete this catalogue with the trajectory of individual blobs and with the latitudinal extent of the SIR. For every SIR we report whether the trajectory of any of the entrained blob impacts a spacecraft in the Heliosphere. For the cases where a blob is predicted to impact one or more spacecraft, we include in the catalogue the predicted arrival time and the date and time of the visually recognized blob which is the closest to the predicted arrival time. This new catalogue was also made available on line on the HELCATS project website. This work was made with the funding from the HELCATS project under the FP7 EU contract number 606692.

European monitoring systems and data for assessing environmental and climate impacts on human infectious diseases.

PubMed

Nichols, Gordon L; Andersson, Yvonne; Lindgren, Elisabet; Devaux, Isabelle; Semenza, Jan C

2014-04-09

Surveillance is critical to understanding the epidemiology and control of infectious diseases. The growing concern over climate and other drivers that may increase infectious disease threats to future generations has stimulated a review of the surveillance systems and environmental data sources that might be used to assess future health impacts from climate change in Europe. We present an overview of organizations, agencies and institutions that are responsible for infectious disease surveillance in Europe. We describe the surveillance systems, tracking tools, communication channels, information exchange and outputs in light of environmental and climatic drivers of infectious diseases. We discuss environmental and climatic data sets that lend themselves to epidemiological analysis. Many of the environmental data sets have a relatively uniform quality across EU Member States because they are based on satellite measurements or EU funded FP6 or FP7 projects with full EU coverage. Case-reporting systems for surveillance of infectious diseases should include clear and consistent case definitions and reporting formats that are geo-located at an appropriate resolution. This will allow linkage to environmental, social and climatic sources that will enable risk assessments, future threat evaluations, outbreak management and interventions to reduce disease burden.

European Monitoring Systems and Data for Assessing Environmental and Climate Impacts on Human Infectious Diseases

PubMed Central

Nichols, Gordon L.; Andersson, Yvonne; Lindgren, Elisabet; Devaux, Isabelle; Semenza, Jan C.

2014-01-01

Surveillance is critical to understanding the epidemiology and control of infectious diseases. The growing concern over climate and other drivers that may increase infectious disease threats to future generations has stimulated a review of the surveillance systems and environmental data sources that might be used to assess future health impacts from climate change in Europe. We present an overview of organizations, agencies and institutions that are responsible for infectious disease surveillance in Europe. We describe the surveillance systems, tracking tools, communication channels, information exchange and outputs in light of environmental and climatic drivers of infectious diseases. We discuss environmental and climatic data sets that lend themselves to epidemiological analysis. Many of the environmental data sets have a relatively uniform quality across EU Member States because they are based on satellite measurements or EU funded FP6 or FP7 projects with full EU coverage. Case-reporting systems for surveillance of infectious diseases should include clear and consistent case definitions and reporting formats that are geo-located at an appropriate resolution. This will allow linkage to environmental, social and climatic sources that will enable risk assessments, future threat evaluations, outbreak management and interventions to reduce disease burden. PMID:24722542

LPE grown LSO:Tb scintillator films for high-resolution X-ray imaging applications at synchrotron light sources

NASA Astrophysics Data System (ADS)

Cecilia, A.; Rack, A.; Douissard, P.-A.; Martin, T.; Dos Santos Rolo, T.; Vagovič, P.; Hamann, E.; van de Kamp, T.; Riedel, A.; Fiederle, M.; Baumbach, T.

2011-08-01

Within the project ScinTAX of the 6th framework program (FP6) of the European Commission (SCINTAX—STRP 033 427) we have developed a new thin single crystal scintillator for high-resolution X-ray imaging. The scintillator is based on a Tb-doped Lu2SiO5 (LSO) film epitaxially grown on an adapted substrate. The high density, effective atomic number and light yield of the scintillating LSO significantly improves the efficiency of the X-ray imaging detectors currently used in synchrotron micro-imaging applications. In this work we present the characterization of the scintillating LSO films in terms of their spatial resolution performance and we provide two examples of high spatial and high temporal resolution applications.

Influence of growing phase feed efficiency classification on finishing phase growth performance and carcass characteristics of beef steers fed different diet types.

PubMed

Russell, J R; Lundy, E L; Minton, N O; Sexten, W J; Kerley, M S; Hansen, S L

2016-07-01

A 5-yr study was conducted using 985 crossbred steers (464 kg [SD 32]) fed in 6 separate, replicated groups to determine the influence of growing phase (GP) feed efficiency (FE) classification and diet type on finishing phase (FP) FE of steers. During the GP at the University of Missouri, steers were fed either a whole shell corn-based diet (G-Corn; 528 steers) or a roughage-based diet (G-Rough; 457 steers) using GrowSafe feed bunks to measure DMI for 69 to 89 d. At the end of the GP, steers were ranked by residual feed intake (RFI) within diet, shipped to Iowa State University, and blocked into FP pens (5 to 6 steers/pen) by GP diet and RFI rank (upper, middle, or lower one-third). Steers were transitioned to either FP cracked corn- or byproduct-based diets and fed until 1.27 cm backfat was reached. After completion of the sixth group, average GP G:F within GP diet was calculated for each FP pen (168 total pens) using GP initial BW as a covariate (G-Corn: 0.207 [SD 0.038]; G-Rough: 0.185 [SD 0.036]). Pens were classified as highly feed efficient (HFE; >0.5 SD from the G:F mean; 58 pens), mid feed efficient (MFE; ±0.5 SD from the G:F mean; 60 pens), or lowly feed efficient (LFE; <0.5 SD from the G:F mean; 50 pens). Data were analyzed using PROC MIXED of SAS. Experimental unit was FP pen and the model included the fixed effects of GP diet, FE classification, FP diet, and the interactions. Group (1 to 6) was included as a fixed effect. There were no 3-way interactions ( ≥ 0.2) for any measured traits. Finishing phase G:F was not affected by any interactions ( ≥ 0.5) but was greater ( ≤ 0.03) for HFE versus MFE and LFE and greater ( = 0.02) for MFE versus LFE. Growing phase diet × FE classification effects were detected ( ≤ 0.01) for FP final BW (FBW), ADG, and DMI. Among G-Rough steers, HFE and MFE had greater ( ≤ 0.04) FBW and ADG than LFE, but among G-Corn steers, LFE had heavier ( = 0.03) FBW than HFE whereas ADG was unaffected ( ≥ 0.2) by FE classification. Dry matter intake was unaffected ( ≥ 0.3) by FE classification among G-Rough steers, but among G-Corn steers, LFE had greater ( ≤ 0.003) DMI than MFE and HFE. Overall, differences in FP G:F between FE classifications were driven by different factors depending on diet; ADG differed among roughage-grown steers and DMI differed among corn-grown steers. Ultimately, steers classified as HFE during the GP still had superior FE during the FP.

Yield Gap, Indigenous Nutrient Supply and Nutrient Use Efficiency for Maize in China.

PubMed

Xu, Xinpeng; Liu, Xiaoyan; He, Ping; Johnston, Adrian M; Zhao, Shicheng; Qiu, Shaojun; Zhou, Wei

2015-01-01

Great achievements have been attained in agricultural production of China, while there are still many difficulties and challenges ahead that call for put more efforts to overcome to guarantee food security and protect environment simultaneously. Analyzing yield gap and nutrient use efficiency will help develop and inform agricultural policies and strategies to increase grain yield. On-farm datasets from 2001 to 2012 with 1,971 field experiments for maize (Zea mays L.) were collected in four maize agro-ecological regions of China, and the optimal management (OPT), farmers' practice (FP), a series of nutrient omission treatments were used to analyze yield gap, nutrient use efficiency and indigenous nutrient supply by adopting meta-analysis and ANOVA analysis. Across all sites, the average yield gap between OPT and FP was 0.7 t ha-1, the yield response to nitrogen (N), phosphorus (P), and potassium (K) were 1.8, 1.0, and 1.2 t ha-1, respectively. The soil indigenous nutrient supply of N, P, and K averaged 139.9, 33.7, and 127.5 kg ha-1, respectively. As compared to FP, the average recovery efficiency (RE) of N, P, and K with OPT increased by percentage point of 12.2, 5.5, and 6.5, respectively. This study indicated that there would be considerable potential to further improve yield and nutrient use efficiency in China, and will help develop and inform agricultural policies and strategies, while some management measures such as soil, plant and nutrient are necessary and integrate with advanced knowledge and technologies.

Yield Gap, Indigenous Nutrient Supply and Nutrient Use Efficiency for Maize in China

PubMed Central

Xu, Xinpeng; Liu, Xiaoyan; He, Ping; Johnston, Adrian M.; Zhao, Shicheng; Qiu, Shaojun; Zhou, Wei

2015-01-01

Great achievements have been attained in agricultural production of China, while there are still many difficulties and challenges ahead that call for put more efforts to overcome to guarantee food security and protect environment simultaneously. Analyzing yield gap and nutrient use efficiency will help develop and inform agricultural policies and strategies to increase grain yield. On-farm datasets from 2001 to 2012 with 1,971 field experiments for maize (Zea mays L.) were collected in four maize agro-ecological regions of China, and the optimal management (OPT), farmers’ practice (FP), a series of nutrient omission treatments were used to analyze yield gap, nutrient use efficiency and indigenous nutrient supply by adopting meta-analysis and ANOVA analysis. Across all sites, the average yield gap between OPT and FP was 0.7 t ha-1, the yield response to nitrogen (N), phosphorus (P), and potassium (K) were 1.8, 1.0, and 1.2 t ha-1, respectively. The soil indigenous nutrient supply of N, P, and K averaged 139.9, 33.7, and 127.5 kg ha-1, respectively. As compared to FP, the average recovery efficiency (RE) of N, P, and K with OPT increased by percentage point of 12.2, 5.5, and 6.5, respectively. This study indicated that there would be considerable potential to further improve yield and nutrient use efficiency in China, and will help develop and inform agricultural policies and strategies, while some management measures such as soil, plant and nutrient are necessary and integrate with advanced knowledge and technologies. PMID:26484543

Effect of diet grinding and pelleting fed either dry or liquid feed on dry matter and pH in the stomach of pigs and the development of gastric ulcers.

PubMed

Mösseler, A; Wintermann, M; Sander, S J; Kamphues, J

2012-12-01

The physical form of diets has a marked impact on the development of gastric ulcers in pigs. Earlier studies showed effects of fine grinding and pelleting on the integrity of gastric mucosa as well as on local intragastric milieu. This study was conducted to evaluate the effects of dry or liquid feeding on intragastric milieu (DM and pH) in pigs. The 23 piglets were housed individually and fed with test diets and water ad lib for 6 wk. Both experimental diets [coarsely ground diet fed as mash (CM) vs. finely ground pelleted diet (FP)] were identical in ingredients (39.5% wheat, 34% barley, 20% soybean meal) and chemical composition and were either offered dry or in liquid (25% DM) form. At the end of the trial the animals were slaughtered; the stomach was removed and samples were taken from different localizations. Feeding diets dry or liquid had no effect on the pH (P > 0.05). The diet noticeably affected the gastric content. The FP diets resulted in a more liquid chyme (P < 0.05), and the intragastric pH did not differ between regions. Feeding CM caused marked effects of localization regarding pH (highest values: pars nonglandularis; lowest values: fundus). None of the pigs fed CM showed signs of gastric ulcers, but the score was markedly higher (P < 0.05) when pigs were fed FP. Therefore the predominant factor for development of gastric ulcers seems to be the structure (particle size) of the diet.

IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis.

PubMed

Steen-Louws, C; Popov-Celeketic, J; Mastbergen, S C; Coeleveld, K; Hack, C E; Eijkelkamp, N; Tryfonidou, M; Spruijt, S; van Roon, J A G; Lafeber, F P J G

2018-05-26

Effective disease-modifying drugs for osteoarthritis (DMOAD) should preferably have chondroprotective, anti-inflammatory, and analgesic activity combined in a single molecule. We developed a fusion protein of IL4 and IL10 (IL4-10 FP), in which the biological activity of both cytokines is preserved. The present study evaluates the chondroprotective, anti-inflammatory, and analgesic activity of IL4-10 FP in in vitro and in vivo models of osteoarthritis. Human osteoarthritic cartilage tissue and synovial tissue were cultured with IL4-10 FP. Cartilage proteoglycan turnover and release of pro-inflammatory, catabolic, and pain mediators by cartilage and synovial tissue were measured. The analgesic effect of intra-articularly injected IL4-10 FP was evaluated in a canine model of osteoarthritis by force-plate analysis. IL4-10 FP increased synthesis (P = 0.018) and decreased release (P = 0.018) of proteoglycans by osteoarthritic cartilage. Release of pro-inflammatory IL6 and IL8 by cartilage and synovial tissue was reduced in the presence of IL4-10 FP (all P < 0.05). The release of MMP3 by osteoarthritic cartilage and synovial tissue was decreased (P = 0.018 and 0.028) whereas TIMP1 production was not significantly changed. Furthermore, IL4-10 FP protected cartilage against destructive properties of synovial tissue mediators shown by the increased cartilage proteoglycan synthesis (P = 0.0235) and reduced proteoglycan release (P = 0.0163). Finally, intra-articular injection of IL4-10 FP improved the deficient joint loading in dogs with experimentally induced osteoarthritis. The results of current preliminary study suggest that IL4-10 FP has DMOAD potentials since it shows chondroprotective and anti-inflammatory effects in vitro, as well as potentially analgesic effect in a canine in vivo model of osteoarthritis. Copyright © 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice.

PubMed

Espley, Richard V; Butts, Christine A; Laing, William A; Martell, Sheridan; Smith, Hannah; McGhie, Tony K; Zhang, Jingli; Paturi, Gunaranjan; Hedderley, Duncan; Bovy, Arnaud; Schouten, Henk J; Putterill, Joanna; Allan, Andrew C; Hellens, Roger P

2014-02-01

Apples are rich in polyphenols, which provide antioxidant properties, mediation of cellular processes such as inflammation, and modulation of gut microbiota. In this study we compared genetically engineered apples with increased flavonoids [myeloblastis transcription factor 10 (MYB10)] with nontransformed apples from the same genotype, "Royal Gala" (RG), and a control diet with no apple. Compared with the RG diet, the MYB10 diet contained elevated concentrations of the flavonoid subclasses anthocyanins, flavanol monomers (epicatechin) and oligomers (procyanidin B2), and flavonols (quercetin glycosides), but other plant secondary metabolites were largely unaltered. We used these apples to investigate the effects of dietary flavonoids on inflammation and gut microbiota in 2 mouse feeding trials. In trial 1, male mice were fed a control diet or diets supplemented with 20% MYB10 apple flesh and peel (MYB-FP) or RG apple flesh and peel (RG-FP) for 7 d. In trial 2, male mice were fed MYB-FP or RG-FP diets or diets supplemented with 20% MYB10 apple flesh or RG apple flesh for 7 or 21 d. In trial 1, the transcription levels of inflammation-linked genes in mice showed decreases of >2-fold for interleukin-2 receptor (Il2rb), chemokine receptor 2 (Ccr2), chemokine ligand 10 (Cxcl10), and chemokine receptor 10 (Ccr10) at 7 d for the MYB-FP diet compared with the RG-FP diet (P < 0.05). In trial 2, the inflammation marker prostaglandin E(2) (PGE(2)) in the plasma of mice fed the MYB-FP diet at 21 d was reduced by 10-fold (P < 0.01) compared with the RG-FP diet. In colonic microbiota, the number of total bacteria for mice fed the MYB-FP diet was 6% higher than for mice fed the control diet at 21 d (P = 0.01). In summary, high-flavonoid apple was associated with decreases in some inflammation markers and changes in gut microbiota when fed to healthy mice.

Full-Shift Trunk and Upper Arm Postures and Movements Among Aircraft Baggage Handlers.

PubMed

Wahlström, Jens; Bergsten, Eva; Trask, Catherine; Mathiassen, Svend Erik; Jackson, Jennie; Forsman, Mikael

2016-10-01

The present study assessed full-shift trunk and upper arm postural exposure amplitudes, frequencies, and durations among Swedish airport baggage handlers and aimed to determine whether exposures differ between workers at the ramp (loading and unloading aircraft) and baggage sorting areas. Trunk and upper arm postures were measured using inclinometers during three full work shifts on each of 27 male baggage handlers working at a large Swedish airport. Sixteen of the baggage handlers worked on the ramp and 11 in the sorting area. Variables summarizing postures and movements were calculated, and mean values and variance components between subjects and within subject (between days) were estimated using restricted maximum likelihood algorithms in a one-way random effect model. In total, data from 79 full shifts (651h) were collected with a mean recording time of 495min per shift (range 319-632). On average, baggage handlers worked with the right and left arm elevated >60° for 6.4% and 6.3% of the total workday, respectively. The 90th percentile trunk forward projection (FP) was 34.1°, and the 50th percentile trunk movement velocity was 8° s(-1). For most trunk (FP) and upper arm exposure variables, between-subject variability was considerable, suggesting that the flight baggage handlers were not a homogeneously exposed group. A notable between-days variability pointed to the contents of the job differing on different days. Peak exposures (>90°) were higher for ramp workers than for sorting area workers (trunk 0.6% ramp versus 0.3% sorting; right arm 1.3% ramp versus 0.7% sorting). Trunk and upper arm postures and movements among flight baggage handlers measured by inclinometry were similar to those found in other jobs comprising manual material handling, known to be associated with increased risks for musculoskeletal disorders. The results showed that full-shift trunk (FP) and, to some extent, peak arm exposures were higher for ramp workers compared with sorting workers. © The Author 2016. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Gas Separation Properties of Polyimide Thin Films on Ceramic Supports for High Temperature Applications

PubMed Central

Escorihuela, Sara; Brinkmann, Torsten

2018-01-01

Novel selective ceramic-supported thin polyimide films produced in a single dip coating step are proposed for membrane applications at elevated temperatures. Layers of the polyimides P84®, Matrimid 5218®, and 6FDA-6FpDA were successfully deposited onto porous alumina supports. In order to tackle the poor compatibility between ceramic support and polymer, and to get defect-free thin films, the effect of the viscosity of the polymer solution was studied, giving the entanglement concentration (C*) for each polymer. The C* values were 3.09 wt. % for the 6FDA-6FpDA, 3.52 wt. % for Matrimid®, and 4.30 wt. % for P84®. A minimum polymer solution concentration necessary for defect-free film formation was found for each polymer, with the inverse order to the intrinsic viscosities (P84® ≥ Matrimid® >> 6FDA-6FpDA). The effect of the temperature on the permeance of prepared membranes was studied for H2, CH4, N2, O2, and CO2. As expected, activation energy of permeance for hydrogen was higher than for CO2, resulting in H2/CO2 selectivity increase with temperature. More densely packed polymers lead to materials that are more selective at elevated temperatures. PMID:29518942

IL-10 and NOS2 Modulate Antigen-Specific Reactivity and Nerve Infiltration by T Cells in Experimental Leprosy

PubMed Central

Hagge, Deanna A.; Scollard, David M.; Ray, Nashone A.; Marks, Vilma T.; Deming, Angelina T.; Spencer, John S.; Adams, Linda B.

2014-01-01

Background Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous lesion can occur. The evolution and maintenance of chronic inflammatory processes like those observed in the leprosy granuloma involve an ongoing network of communications via cytokines. IL-10 has immunosuppressive properties and IL-10 genetic variants have been associated with leprosy development and reactions. Methodology/Principal Findings The role of IL-10 in resistance and inflammation in leprosy was investigated using Mycobacterium leprae infection of mice deficient in IL-10 (IL-10−/−), as well as mice deficient in both inducible nitric oxide synthase (NOS2−/−) and IL-10 (10NOS2−/−). Although a lack of IL-10 did not affect M. leprae multiplication in the footpads (FP), inflammation increased from C57Bl/6 (B6)

Influence of hormonal therapy in prostate cancer patients undergoing [18F]fluoromethyl choline PET/CT: a retrospective study.

PubMed

Palumbo, Barbara; Sivolella, Silvio; Palumbo, Isabella; Buresta, Tommaso; Radicchia, Valentina; Fravolini, Mario L; Ferretti, Francesca; Bellavita, Rita; Mearini, Luigi; Scialpi, Michele; Aristei, Cynthia; Pelliccia, Gianfranco

2016-12-01

Patients with suspected recurrence of prostate cancer undergoing [18F]fluoromethyl choline ([18F]FCH) PET/CT were retrospectively evaluated to investigate the influence of hormonal therapy (HT) in [18F]FCH uptake. [18F]FCH PET/CT was performed in 102 surgically treated patients with suspected recurrence (PSA increase >0.2 ng/mL) of prostate cancer, divided in two groups: under HT (N.=54) and without HT (N.=48) at the time of PET scanning. PET/CT was carried out by an integrated system (Biograph 6, CTI/Siemens, Knoxville, TN, USA) intravenously by administering 4.1 MBq/kg of [18F]FCH to each patient; images were acquired 60 minutes later. On the total number of patients, 66 were found to be true positives (TP), 9 false positives (FP), 5 false negatives (FN) and 22 true negatives (TN), sensitivity to [18F]FCH PET/CT was 93%, specificity 71%, accuracy 86%, positive predictive value (PPV) 88%, negative predictive value (NPV) 81%. In the 54 patients under HT, 38 were TP, 6 FP, 3 FN and 7 TN, sensitivity was 93%, specificity 54%, accuracy 83%, PPV 86% and NPV was 70%. In the 48 patients receiving no HT, 28 were TP, 3 FP, 2 FN and 15 TN, sensitivity was 93%, specificity 83%, accuracy 90%, PPV 90% and NPV 88%. A χ2 test showed that sensitivity, accuracy and PPV did not differ among patients with and without HT, while specificity and NPV were significantly lower (P<0.001) in HT treated patients. Sensitivity, accuracy and PPV were similar in patients with and without HT. Specificity and NPV were reduced in patients under HT, but further data are necessary to support if this reduction is casual or related to therapy and it could be confirmed in a larger series of patients.

An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors.

PubMed

Hu, Mingming; Guan, Hongzhi; Lau, Ching C; Terashima, Keita; Jin, Zimeng; Cui, Liying; Wang, Yuzhou; Li, Guilin; Yao, Yong; Guo, Yi; Li, Yan Michael; Zhong, Dingrong; Xiao, Juan; Wan, Xirun; Lian, Xin; Feng, Feng; Ren, Haitao; Zhao, Yanhuan; Cheng, Xinqi; Gu, Feng

2016-03-12

Pathological examination combined with tumor markers has become a standard for the diagnosis of intracranial germ cell tumors (ICGCTs), but the current concept of 'secreting germ cell tumors' and three empirically highly specific diagnostic criteria (β-hCG ≥ 50 IU/L or αFP ≥ 10 ng/mL; β-hCG ≥ 100 IU/L or αFP ≥ 50 ng/mL; β-hCG > 50 IU/L or αFP > 25 ng/mL) are not based upon pathology examination or CSF cytology. Further investigation is needed to re-evaluate their value. A multidisciplinary diagnostic team was created. Valid β-hCG/αFP data were collected from cases of ICGCTs confirmed by pathology and CSF cytology (n = 58) between 1991 and 2012, and from suspected ICGCTs cases (n = 17) between 2011 and 2012 as controls [Langerhans cell histiocytosis (LCH), n = 12; and other intracranial tumor (ICT), n = 5]. The cut-off points for β-hCG and αFP were calculated using receiver operating characteristic (ROC) curves. This study clarifies the relative rationality of one criteria (β-hCG > 50 IU/L and αFP > 25 ng/mL); confirms new β-hCG diagnostic cut-off points: CSF β-hCG ≥ 8.2 IU/L and serum β-hCG ≥ 2.5 IU/L (sensitivity of 47 and 34%, respectively, specificity of 100%, both; P < 0.05); and empirically adjusts the criteria for αFP to ≥ 3.8 ng/mL in CSF and to ≥ 25 ng/mL in serum. The total diagnostic sensitivity for ICGCTs finally increased from 34.6 to 65.4% (P < 0.05, diagnostic value of CSF β-hCG exceeds 90%). Subtype diagnosis improved with αFP in 16.7% of non-geminomatous germ cell tumor cases. New evidence-based criteria of β-hCG and αFP can help improving early and formal diagnosis of ICGCTs, and is of great clinical significance.

Providing maternal and child health-family planning services to a large rural population: results of the Bohol Project, Philippines.

PubMed Central

Williamson, N E; Parado, J P; Maturan, E G

1983-01-01

The Bohol Project (1975-1979) sought to improve maternal and child health and to increase the use of family planning among a rural Philippine population of 400,000. Research indicated that maternal and child health (MCH) services did become more available during the Project period and coverage of the priority populations improved. Family planning (FP) use, particularly of less effective methods, increased and fertility declined although some change could have been expected even without the Project. Deaths due to neonatal tetanus were almost eliminated by mortality rates did not decline for a number of reasons, including the fact that services were probably not tailored closely enough to local health problems, especially respiratory diseases. The Project showed that it was possible to increase health and family planning services by using low-cost strategies (such as setting up community drug stores) and by employing paramedical workers, in this case, midwives. Preventive MCH-FP services were not overwhelmed by curative services as had been feared. Perhaps the most significant contributions of the Project were the lessons learned about delivering health and family planning services and conducting evaluation research. In general, if developing countries could maintain well-evaluated field laboratories for working out health and family planning delivery approaches before going nationwide, it is likely that time and money would be saved in the long run. PMID:6848001

Investigating dynamical complexity in the time series of the upgraded ENIGMA magnetometer array using various entropy measures

NASA Astrophysics Data System (ADS)

Balasis, Georgios; Daglis, Ioannis A.; Papadimitriou, Constantinos; Melis, Nikolaos; Giannakis, Omiros; Kontoes, Charalampos

2016-04-01

The HellENIc GeoMagnetic Array (ENIGMA) is a network of 3 ground-based magnetometer stations in the areas of Trikala, Attiki and Lakonia in Greece that provides measurements for the study of geomagnetic pulsations, resulting from the solar wind - magnetosphere coupling. ENIGMA magnetometer array enables effective remote sensing of geospace dynamics and the study of space weather effects on the ground (i.e., Geomagnetically Induced Currents - GIC). ENIGMA contributes data to SuperMAG, a worldwide collaboration of organizations and national agencies that currently operate more than 300 ground-based magnetometers. ENIGMA is currently extended and upgraded receiving financial support through the national funding KRIPIS project and European Commission's BEYOND project. In particular, the REGPOT project BEYOND is an FP7 project that aims to maintain and expand the existing state-of-the-art interdisciplinary research potential, by Building a Centre of Excellence for Earth Observation based monitoring of Natural Disasters in south-eastern Europe, with a prospect to increase its access range to the wider Mediterranean region through the integrated cooperation with twining organizations. This study explores the applicability and effectiveness of a variety of computable entropy measures to the ENIGMA time series in order to investigate dynamical complexity between pre-storm activity and magnetic storms.

OCULUS fire: a command and control system for fire management with crowd sourcing and social media interconnectivity

NASA Astrophysics Data System (ADS)

Thomopoulos, Stelios C. A.; Kyriazanos, Dimitris M.; Astyakopoulos, Alkiviadis; Dimitros, Kostantinos; Margonis, Christos; Thanos, Giorgos Konstantinos; Skroumpelou, Katerina

2016-05-01

AF3 (Advanced Forest Fire Fighting2) is a European FP7 research project that intends to improve the efficiency of current fire-fighting operations and the protection of human lives, the environment and property by developing innovative technologies to ensure the integration between existing and new systems. To reach this objective, the AF3 project focuses on innovative active and passive countermeasures, early detection and monitoring, integrated crisis management and advanced public information channels. OCULUS Fire is the innovative control and command system developed within AF3 as a monitoring, GIS and Knowledge Extraction System and Visualization Tool. OCULUS Fire includes (a) an interface for real-time updating and reconstructing of maps to enable rerouting based on estimated hazards and risks, (b) processing of GIS dynamic re-construction and mission re-routing, based on the fusion of airborne, satellite, ground and ancillary geolocation data, (c) visualization components for the C2 monitoring system, displaying and managing information arriving from a variety of sources and (d) mission and situational awareness module for OCULUS Fire ground monitoring system being part of an Integrated Crisis Management Information System for ground and ancillary sensors. OCULUS Fire will also process and visualise information from public information channels, social media and also mobile applications by helpful citizens and volunteers. Social networking, community building and crowdsourcing features will enable a higher reliability and less false alarm rates when using such data in the context of safety and security applications.

The Faber–Jackson relation and Fundamental Plane from halo abundance matching

DOE PAGES

Desmond, Harry; Wechsler, Risa H.

2016-11-02

The Fundamental Plane (FP) describes the relation between the stellar mass, size, and velocity dispersion of elliptical galaxies; the Faber–Jackson relation (FJR) is its projection on to {mass, velocity} space. In this work, we re-deploy and expand the framework of Desmond & Wechsler to ask whether abundance matching-based Λ-cold dark matter models which have shown success in matching the spatial distribution of galaxies are also capable of explaining key properties of the FJR and FP, including their scatter. Within our framework, agreement with the normalization of the FJR requires haloes to expand in response to disc formation. We find thatmore » the tilt of the FP may be explained by a combination of the observed non-homology in galaxy structure and the variation in mass-to-light ratio produced by abundance matching with a universal initial mass function, provided that the anisotropy of stellar motions is taken into account. However, the predicted scatter around the FP is considerably increased by situating galaxies in cosmologically motivated haloes due to the variations in halo properties at fixed stellar mass and appears to exceed that of the data. Finally, this implies that additional correlations between galaxy and halo variables may be required to fully reconcile these models with elliptical galaxy scaling relations.« less

First-Year Students' Priorities and Choices in STEM Studies--IRIS Findings from Germany and Austria

ERIC Educational Resources Information Center

Elster, D.

2014-01-01

IRIS (Interests and Recruitment in Science; http://iris.fp-7.org/about-iris/) is a European 7th framework project focusing on the challenge that only few young people in general, and women in particular, choose an education and career in science and technology. Project IRIS aims to contribute to the improvement of recruitment, retention and gender…

The Design and Implementation of a Parallel Persistent Object System

DTIC Science & Technology

1992-02-01

Semantica JilP L Add descriptor (FP.L) to active pool JMPF r L If Frames, FP+r.O-0 Add descriptor (FP,L) to active pool Else Add descriptor (FP, IP+l...Syntax Semantica STARTO rl r2 Let FP’ = Frames[FP+rl] Let IP’ - Frames[FP+r2] Add (FP.IP+I) to active pool Add (FP I, P’ ) to active pool STARTI rl r2 r3...deadlock. 119 Syntaz Semantica ALLOCFRANE ri rj Let CallerFP - Frames [FP+ri] Let ResultIP - Frames [FP+ri+1] Let SignalIP = Frames [FP+ri+2] Let ResSlot

Development of a high resolution optical-fiber tilt sensor by F-P filter

NASA Astrophysics Data System (ADS)

Pan, Jianjun; Nan, Qiuming; Li, Shujie; Hao, Zhonghua

2017-04-01

A high-resolution tilt sensor is developed, which is composed of a pair of optical fiber collimators and a simple pendulum with an F-P filter. The tilt angle is measured by demodulating the shift of center wavelength of F-P filter, which is caused by incidence angle changing. The relationship between tilted angle and the center wavelength is deduced. Calibration experiment results also confirm the deduction, and show that it is easy to obtain a high resolution. Setting the initial angle to 6degree, the measurement range is ±3degree, its average sensitivity is 1104pm/degree, and its average resolution is as high as 0.0009degree.

Evidence from cluster surveys on the association between home-based counseling and use of family planning in conflict-affected Darfur.

PubMed

Adam, Izzeldin F

2016-05-01

To examine the association between home counseling and awareness and use of modern family planning (FP) methods among women in internally displaced person (IDP) camps in conflict-affected West Darfur, Sudan. In a community-based cross-sectional study, two questionnaire-based surveys were performed in three camps. Home-based counseling had been introduced in March 2006. An initial survey (February 2007) and a follow-up survey (April 2009) targeted women of child-bearing age. A sample of 640 randomly selected women aged 15-49 years who had experienced pregnancy after joining the camp were interviewed for each survey. Overall, modern FP use increased from 10.9% (70/640) in 2007 to 21.6% (138/640) in 2009 (P<0.001). As compared with the initial survey, women in the follow-up survey were more likely to be aware of and to use any modern FP method (adjusted odds ratio [aOR] 5.4, 95% confidence interval [CI] 3.9-7.4; and aOR 2.8, 95% CI 2.0-4.1, respectively). Contraceptive pills were the most common modern method used. Home counseling and loss of a child under 5years were the most significant predictors of awareness and use of modern FP methods. After the introduction of home-based FP counseling for couples and FP services in clinics, women's awareness and use of modern FP methods increased in a conflict-affected setting. Copyright © 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy improves in vivo diagnosis of esophageal squamous cell carcinoma at endoscopy

NASA Astrophysics Data System (ADS)

Wang, Jianfeng; Lin, Kan; Zheng, Wei; Yu Ho, Khek; Teh, Ming; Guan Yeoh, Khay; Huang, Zhiwei

2015-08-01

This work aims to evaluate clinical value of a fiber-optic Raman spectroscopy technique developed for in vivo diagnosis of esophageal squamous cell carcinoma (ESCC) during clinical endoscopy. We have developed a rapid fiber-optic Raman endoscopic system capable of simultaneously acquiring both fingerprint (FP)(800-1800 cm-1) and high-wavenumber (HW)(2800-3600 cm-1) Raman spectra from esophageal tissue in vivo. A total of 1172 in vivo FP/HW Raman spectra were acquired from 48 esophageal patients undergoing endoscopic examination. The total Raman dataset was split into two parts: 80% for training; while 20% for testing. Partial least squares-discriminant analysis (PLS-DA) and leave-one patient-out, cross validation (LOPCV) were implemented on training dataset to develop diagnostic algorithms for tissue classification. PLS-DA-LOPCV shows that simultaneous FP/HW Raman spectroscopy on training dataset provides a diagnostic sensitivity of 97.0% and specificity of 97.4% for ESCC classification. Further, the diagnostic algorithm applied to the independent testing dataset based on simultaneous FP/HW Raman technique gives a predictive diagnostic sensitivity of 92.7% and specificity of 93.6% for ESCC identification, which is superior to either FP or HW Raman technique alone. This work demonstrates that the simultaneous FP/HW fiber-optic Raman spectroscopy technique improves real-time in vivo diagnosis of esophageal neoplasia at endoscopy.

Grid enablement of OpenGeospatial Web Services: the G-OWS Working Group

NASA Astrophysics Data System (ADS)

Mazzetti, Paolo

2010-05-01

In last decades two main paradigms for resource sharing emerged and reached maturity: the Web and the Grid. They both demonstrate suitable for building Distributed Computing Infrastructures (DCIs) supporting the coordinated sharing of resources (i.e. data, information, services, etc) on the Internet. Grid and Web DCIs have much in common as a result of their underlying Internet technology (protocols, models and specifications). However, being based on different requirements and architectural approaches, they show some differences as well. The Web's "major goal was to be a shared information space through which people and machines could communicate" [Berners-Lee 1996]. The success of the Web, and its consequent pervasiveness, made it appealing for building specialized systems like the Spatial Data Infrastructures (SDIs). In this systems the introduction of Web-based geo-information technologies enables specialized services for geospatial data sharing and processing. The Grid was born to achieve "flexible, secure, coordinated resource sharing among dynamic collections of individuals, institutions, and resources" [Foster 2001]. It specifically focuses on large-scale resource sharing, innovative applications, and, in some cases, high-performance orientation. In the Earth and Space Sciences (ESS) the most part of handled information is geo-referred (geo-information) since spatial and temporal meta-information is of primary importance in many application domains: Earth Sciences, Disasters Management, Environmental Sciences, etc. On the other hand, in several application areas there is the need of running complex models which require the large processing and storage capabilities that the Grids are able to provide. Therefore the integration of geo-information and Grid technologies might be a valuable approach in order to enable advanced ESS applications. Currently both geo-information and Grid technologies have reached a high level of maturity, allowing to build such an integration on existing solutions. More specifically, the Open Geospatial Consortium (OGC) Web Services (OWS) specifications play a fundamental role in geospatial information sharing (e.g. in INSPIRE Implementing Rules, GEOSS architecture, GMES Services, etc.). On the Grid side, the gLite middleware, developed in the European EGEE (Enabling Grids for E-sciencE) Projects, is widely spread in Europe and beyond, proving its high scalability and it is one of the middleware chosen for the future European Grid Infrastructure (EGI) initiative. Therefore the convergence between OWS and gLite technologies would be desirable for a seamless access to the Grid capabilities through OWS-compliant systems. Anyway, to achieve this harmonization there are some obstacles to overcome. Firstly, a semantics mismatch must be addressed: gLite handle low-level (e.g. close to the machine) concepts like "file", "data", "instruments", "job", etc., while geo-information services handle higher-level (closer to the human) concepts like "coverage", "observation", "measurement", "model", etc. Secondly, an architectural mismatch must be addressed: OWS implements a Web Service-Oriented-Architecture which is stateless, synchronous and with no embedded security (which is demanded to other specs), while gLite implements the Grid paradigm in an architecture which is stateful, asynchronous (even not fully event-based) and with strong embedded security (based on the VO paradigm). In recent years many initiatives and projects have worked out possible approaches for implementing Grid-enabled OWSs. Just to mention some: (i) in 2007 the OGC has signed a Memorandum of Understanding with the Open Grid Forum, "a community of users, developers, and vendors leading the global standardization effort for grid computing."; (ii) the OGC identified "WPS Profiles - Conflation; and Grid processing" as one of the tasks in the Geo Processing Workflow theme of the OWS Phase 6 (OWS-6); (iii) several national, European and international projects investigated different aspects of this integration, developing demonstrators and Proof-of-Concepts; In this context, "gLite enablement of OpenGeospatial Web Services" (G-OWS) is an initiative started in 2008 by the European CYCLOPS, GENESI-DR, and DORII Projects Consortia in order to collect/coordinate experiences on the enablement of OWS on top of the gLite middleware [GOWS]. Currently G-OWS counts ten member organizations from Europe and beyond, and four European Projects involved. It broadened its scope to the development of Spatial Data and Information Infrastructures (SDI and SII) based on the Grid/Cloud capacity in order to enable Earth Science applications and tools. Its operational objectives are the following: i) to contribute to the OGC-OGF initiative; ii) to release a reference implementation as standard gLite APIs (under the gLite software license); iii) to release a reference model (including procedures and guidelines) for OWS Grid-ification, as far as gLite is concerned; iv) to foster and promote the formation of consortiums for participation to projects/initiatives aimed at building Grid-enabled SDIs To achieve this objectives G-OWS bases its activities on two main guiding principles: a) the adoption of a service-oriented architecture based on the information modelling approach, and b) standardization as a means of achieving interoperability (i.e. adoption of standards from ISO TC211, OGC OWS, OGF). In the first year of activity G-OWS has designed a general architectural framework stemming from the FP6 CYCLOPS studies and enriched by the outcomes of other projects and initiatives involved (i.e. FP7 GENESI-DR, FP7 DORII, AIST GeoGrid, etc.). Some proof-of-concepts have been developed to demonstrate the flexibility and scalability of such architectural framework. The G-OWS WG developed implementations of gLite-enabled Web Coverage Service (WCS) and Web Processing Service (WPS), and an implementation of a Shibboleth authentication for gLite-enabled OWS in order to evaluate the possible integration of Web and Grid security models. The presentation will aim to communicate the G-OWS organization, activities, future plans and means to involve the ESSI community. References [Berners-Lee 1996] T. Berners-Lee, "WWW: Past, present, and future". IEEE Computer, 29(10), Oct. 1996, pp. 69-77. [Foster 2001] I. Foster, C. Kesselman and S. Tuecke, "The Anatomy of the Grid. The International Journal ofHigh Performance Computing Applications", 15(3):200-222, Fall 2001 [GOWS] G-OWS WG, https://www.g-ows.org/, accessed: 15 January 2010

Highlight removal based on the regional-projection fringe projection method

NASA Astrophysics Data System (ADS)

Qi, Zhaoshuai; Wang, Zhao; Huang, Junhui; Xing, Chao; Gao, Jianmin

2018-04-01

In fringe projection profilometry, highlight usually causes the saturation and blooming in captured fringes and reduces the measurement accuracy. To solve the problem, a regional-projection fringe projection (RP-FP) method is proposed. Regional projection patterns (RP patterns) are projected onto the tested object surface to avoid the saturation and blooming. Then, an image inpainting technique is employed to reconstruct the missing phases in the captured RP patterns and a complete surface of the tested object is obtained. Experiments verified the effectiveness of the proposed method. The method can be widely used in industrial inspections and quality controlling in mechanical and manufacturing industries.

New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents.

PubMed

Nakajima, Tadashi; Matsugi, Takeshi; Goto, Wakana; Kageyama, Masaaki; Mori, Nobuaki; Matsumura, Yasushi; Hara, Hideaki

2003-12-01

To find new prostanoid FP-receptor agonists possessing potent ocular-hypotensive effects with minimal side effects, we evaluated the agonistic activities of newly synthesized prostaglandin F(2alpha) derivatives for the prostanoid FP-receptor both in vitro and in vivo. The iris constrictions induced by the derivatives and their effects on melanin content were examined using cat isolated iris sphincters and cultured B16 melanoma cells, respectively. The effects of derivative ester forms on miosis and intraocular pressure (IOP) were evaluated in cats and cynomolgus monkeys, respectively. Of these derivatives, 6 out of 12 compounds were more potent iris constrictors, with EC(50) values of 0.6 to 9.4 nM, than a carboxylic acid of latanoprost (EC(50)=13.6 nM). A carboxylic acid of latanoprost (100 microM) significantly increased the melanin content of cultured B16 melanoma cells, but some 15,15-difluoro derivatives, such as AFP-157 and AFP-172, did not. Topically applied AFP-168, AFP-169 and AFP-175 (isopropyl ester, methyl ester and ethyl ester forms, respectively, of AFP-172) induced miosis in cats more potently than latanoprost. AFP-168 (0.0005%) reduced IOP to the same extent as 0.005% latanoprost (for at least 8 h). These findings indicate that 15,15-difluoroprostaglandin F(2alpha) derivatives, especially AFP-168, have more potent prostanoid FP-receptor agonistic activities than latanoprost. Hence, AFP-168 may be worthy of further evaluation as an ocular-hypotensive agent.

Protective immune response of chickens to oral vaccination with thermostable live Fowlpox virus vaccine (strain TPV-1) coated on oiled rice.

PubMed

Wambura, Philemon N; Godfrey, S K

2010-03-01

The objective of the present study was to develop and evaluate a local vaccine (strain TPV-1) against Fowl pox (FP) in chickens. Two separate groups of chickens were vaccinated with FP vaccine through oral (coated on oiled rice) and wing web stab routes, respectively. The results showed that the haemagglutination-inhibition (HI) antibody titres in both vaccinated groups were comparable and significantly higher (P < 0.05) than the control chickens. It was further revealed that 14 days after vaccination HI GMT of > or =2 log(2) was recorded in chickens vaccinated by oral and wing web stab routes whereas 35 days after vaccination the HI antibody titres reached 5.6 log(2) and 6.3 log(2), respectively. Moreover, in both groups the birds showed 100% protection against challenge virus at 35 days after vaccination. The findings from the present study have shown that oral route is equally effective as wing web stab route for vaccination of chickens against FP. However, the oral route can be used in mass vaccination of birds thus avoid catching individual birds for vaccination. It was noteworthy that strain TPV-1 virus could be propagated by a simple allantoic cavity inoculation and harvesting of allantoic fluid where it survived exposure at 57 degrees C for 2 hours. If the oral vaccination technique is optimized it may be used in controlling FP in scavenging and feral chickens. In conclusion, the present study has shown that FP vaccine (strain TPV-1) was safe, thermostable, immunogenic and efficacious in vaccinated chickens.

Modelling tools for managing Induced RiverBank Filtration MAR schemes

NASA Astrophysics Data System (ADS)

De Filippis, Giovanna; Barbagli, Alessio; Marchina, Chiara; Borsi, Iacopo; Mazzanti, Giorgio; Nardi, Marco; Vienken, Thomas; Bonari, Enrico; Rossetto, Rudy

2017-04-01

Induced RiverBank Filtration (IRBF) is a widely used technique in Managed Aquifer Recharge (MAR) schemes, when aquifers are hydraulically connected with surface water bodies, with proven positive effects on quality and quantity of groundwater. IRBF allows abstraction of a large volume of water, avoiding large decrease in groundwater heads. Moreover, thanks to the filtration process through the soil, the concentration of chemical species in surface water can be reduced, thus becoming an excellent resource for the production of drinking water. Within the FP7 MARSOL project (demonstrating Managed Aquifer Recharge as a SOLution to water scarcity and drought; http://www.marsol.eu/), the Sant'Alessio IRBF (Lucca, Italy) was used to demonstrate the feasibility and technical and economic benefits of managing IRBF schemes (Rossetto et al., 2015a). The Sant'Alessio IRBF along the Serchio river allows to abstract an overall amount of about 0.5 m3/s providing drinking water for 300000 people of the coastal Tuscany (mainly to the town of Lucca, Pisa and Livorno). The supplied water is made available by enhancing river bank infiltration into a high yield (10-2 m2/s transmissivity) sandy-gravelly aquifer by rising the river head and using ten vertical wells along the river embankment. A Decision Support System, consisting in connected measurements from an advanced monitoring network and modelling tools was set up to manage the IRBF. The modelling system is based on spatially distributed and physically based coupled ground-/surface-water flow and solute transport models integrated in the FREEWAT platform (developed within the H2020 FREEWAT project - FREE and Open Source Software Tools for WATer Resource Management; Rossetto et al., 2015b), an open source and public domain GIS-integrated modelling environment for the simulation of the hydrological cycle. The platform aims at improving water resource management by simplifying the application of EU water-related Directives and at facilitating the use of modeling environments and GIS tools for storage, management and visualization of large spatial datasets. The groundwater flow and solute transport model was built using FREEWAT, where MODFLOW-2005 and MT3DMS are integrated. The aquifer of the Sant'Alessio plain was discretized using square cells 100 m2 wide and two model layers, a silty-sandy superficial cover and the sandy-gravelly aquifer. Hydraulic connection with the Serchio river and exploitation of the aquifer through the Sant'Alessio well field were simulated. The aquifer model layer was further refined to simulate advection, dispersion, sorption and degradation of contaminants within the river. The objectives are: (i) estimating induced infiltration rates and travel times, (ii) optimizing groundwater exploitation in complex well field schemes, (iii) preventing pollution events, (iv) estimating time for remedial actions. Acknowledgements This paper is presented within the framework of the projects FP7 MARSOL and H2020 FREEWAT. The MARSOL project has received funding from the European Union's Seventh Framework Programme for Research, Technological Development and Demonstration under grant agreement no 619120. The FREEWAT project has received funding from the European Union's HORIZON 2020

Assessment of the unattached fraction of indoor radon progeny and its contribution to dose: a pilot study in China.

PubMed

Guo, Qiuju; Zhang, Lei; Guo, Lu

2012-12-01

The unattached fraction of radon progeny (f(p)) is one of the most important factors for accurate evaluation of the effective dose from a unit of radon exposure, and it may vary greatly in different environments. For precise evaluation of the indoor radon exposure dose and the influence of unattached radon progeny, a pilot survey of f(p) in different environments was carried out in China with a portable and integrating monitor. The dose conversion factors for radon progeny are calculated with LUDEP(®) code, and the dose contributions from the unattached and the attached radon progenies were simultaneously evaluated based on the results of field measurements. The results show that even though the concentrations of radon progeny vary significantly among different indoor environments, the variations of f(p) seem relatively small (9.3-16.9%). The dose contribution from unattached radon progeny is generally larger (30.2-46.2%) in an indoor environment.

Fiber Optic Fabry-Perot Current Sensor Integrated with Magnetic Fluid Using a Fiber Bragg Grating Demodulation

PubMed Central

Xia, Ji; Wang, Qi; Liu, Xu; Luo, Hong

2015-01-01

An optical fiber current sensor based on Fabry-Perot interferometer using a fiber Bragg grating demodulation is proposed. Magnetic fluid is used as a sensitive medium in fiber optical Fabry-Perot (F-P) cavity for the optical characteristic of magnetic-controlled refractive index. A Fiber Bragg grating (FBG) is connected after the F-P interferometer which is used to reflect the optical power at the Bragg wavelength of the interference transmission spectrum. The corresponding reflective power of the FBG will change with different external current intensity, due to the shift on the interference spectrum of the F-P interferometer. The sensing probe has the advantages of convenient measurement for its demodulation, low cost and high current measurement accuracy on account of its sensing structure. Experimental results show that an optimal sensitivity of 0.8522 nw/A and measurement resolution of 0.001 A is obtained with a FBG at 1550 nm with 99% reflectivity. PMID:26184201

Fiber Optic Fabry-Perot Current Sensor Integrated with Magnetic Fluid Using a Fiber Bragg Grating Demodulation.

PubMed

Xia, Ji; Wang, Qi; Liu, Xu; Luo, Hong

2015-07-09

An optical fiber current sensor based on Fabry-Perot interferometer using a fiber Bragg grating demodulation is proposed. Magnetic fluid is used as a sensitive medium in fiber optical Fabry-Perot (F-P) cavity for the optical characteristic of magnetic-controlled refractive index. A Fiber Bragg grating (FBG) is connected after the F-P interferometer which is used to reflect the optical power at the Bragg wavelength of the interference transmission spectrum. The corresponding reflective power of the FBG will change with different external current intensity, due to the shift on the interference spectrum of the F-P interferometer. The sensing probe has the advantages of convenient measurement for its demodulation, low cost and high current measurement accuracy on account of its sensing structure. Experimental results show that an optimal sensitivity of 0.8522 nw/A and measurement resolution of 0.001 A is obtained with a FBG at 1550 nm with 99% reflectivity.

Hybrid wireless-over-fiber transmission system based on multiple injection-locked FP LDs.

PubMed

Li, Chung-Yi; Lu, Hai-Han; Chu, Chien-An; Ying, Cheng-Ling; Lu, Ting-Chien; Peng, Peng-Chun

2015-07-27

A hybrid wireless-over-fiber (WoF) transmission system based on multiple injection-locked Fabry-Perot laser diodes (FP LDs) is proposed and experimentally demonstrated. Unlike the traditional hybrid WoF transmission systems that require multiple distributed feedback (DFB) LDs to support different kinds of services, the proposed system employs multiple injection-locked FP LDs to provide different kinds of applications. Such a hybrid WoF transmission system delivers downstream intensity-modulated 20-GHz microwave (MW)/60-GHz millimeter-wave (MMW)/550-MHz cable television (CATV) signals and upstream phase-remodulated 20-GHz MW signal. Excellent bit error rate (BER), carrier-to-noise ratio (CNR), composite second-order (CSO), and composite triple-beat (CTB) are observed over a 40-km single-mode fiber (SMF) and a 4-m radio frequency (RF) wireless transport. Such a hybrid WoF transmission system has practical applications for fiber-wireless convergence to provide broadband integrated services, including telecommunication, data communication, and CATV services.

Couple Characteristics and Contraceptive Use among Women and their Partners in Urban Kenya

PubMed Central

Irani, Laili; Speizer, Ilene S.; Fotso, Jean-Christophe

2014-01-01

Background Few studies have used couple data to identify individual- and relationship-level characteristics that affect contraceptive use in urban areas. Using matched couple data from urban Kenya collected in 2010, this study determines the association between relationship-level characteristics (desire for another child, communication about desired number of children and FP use) and contraceptive use and intention to use among non-users. Methods Data were collected from three Kenyan cities: Nairobi, Mombasa and Kisumu. Baseline population-based survey data from the Measurement, Learning & Evaluation Project were used to identify 883couples (weighted value=840). Multivariate regressions used the couple as the unit of analysis. Results Almost two-thirds of couples currently used contraception. Adjusting for individual- and environmental-level characteristics, couples who desired another child were less likely to use contraception than couples wanting more children. In addition, couples where both partners reported communicating with each other regarding desired number of children and FP use were more likely to use contraception compared to couples that did not communicate. Analyses testing the association of relationship-level characteristics and intention to use contraception, among non-users, resembled those of current contraceptive users. Conclusion Couple-level characteristics are associated with current contraceptive use and future intent to use. Couples that discussed their desired number of children and FP use were more likely to use contraception than couples that did not communicate with each other. FP programs should identify strategies to improve communication in FP among couples and to ensure better cooperation between partners. PMID:24733057

A Common Calibration Source Framework for Fully-Polarimetric and Interferometric Radiometers

NASA Technical Reports Server (NTRS)

Kim, Edward J.; Davis, Brynmor; Piepmeier, Jeff; Zukor, Dorothy J. (Technical Monitor)

2000-01-01

Two types of microwave radiometry--synthetic thinned array radiometry (STAR) and fully-polarimetric (FP) radiometry--have received increasing attention during the last several years. STAR radiometers offer a technological solution to achieving high spatial resolution imaging from orbit without requiring a filled aperture or a moving antenna, and FP radiometers measure extra polarization state information upon which entirely new or more robust geophysical retrieval algorithms can be based. Radiometer configurations used for both STAR and FP instruments share one fundamental feature that distinguishes them from more 'standard' radiometers, namely, they measure correlations between pairs of microwave signals. The calibration requirements for correlation radiometers are broader than those for standard radiometers. Quantities of interest include total powers, complex correlation coefficients, various offsets, and possible nonlinearities. A candidate for an ideal calibration source would be one that injects test signals with precisely controllable correlation coefficients and absolute powers simultaneously into a pair of receivers, permitting all of these calibration quantities to be measured. The complex nature of correlation radiometer calibration, coupled with certain inherent similarities between STAR and FP instruments, suggests significant leverage in addressing both problems together. Recognizing this, a project was recently begun at NASA Goddard Space Flight Center to develop a compact low-power subsystem for spaceflight STAR or FP receiver calibration. We present a common theoretical framework for the design of signals for a controlled correlation calibration source. A statistical model is described, along with temporal and spectral constraints on such signals. Finally, a method for realizing these signals is demonstrated using a Matlab-based implementation.

Parallel Fokker–Planck-DSMC algorithm for rarefied gas flow simulation in complex domains at all Knudsen numbers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Küchlin, Stephan, E-mail: kuechlin@ifd.mavt.ethz.ch; Jenny, Patrick

2017-01-01

A major challenge for the conventional Direct Simulation Monte Carlo (DSMC) technique lies in the fact that its computational cost becomes prohibitive in the near continuum regime, where the Knudsen number (Kn)—characterizing the degree of rarefaction—becomes small. In contrast, the Fokker–Planck (FP) based particle Monte Carlo scheme allows for computationally efficient simulations of rarefied gas flows in the low and intermediate Kn regime. The Fokker–Planck collision operator—instead of performing binary collisions employed by the DSMC method—integrates continuous stochastic processes for the phase space evolution in time. This allows for time step and grid cell sizes larger than the respective collisionalmore » scales required by DSMC. Dynamically switching between the FP and the DSMC collision operators in each computational cell is the basis of the combined FP-DSMC method, which has been proven successful in simulating flows covering the whole Kn range. Until recently, this algorithm had only been applied to two-dimensional test cases. In this contribution, we present the first general purpose implementation of the combined FP-DSMC method. Utilizing both shared- and distributed-memory parallelization, this implementation provides the capability for simulations involving many particles and complex geometries by exploiting state of the art computer cluster technologies.« less

RX J0848.6+4453: The evolution of galaxy sizes and stellar populations in A z = 1.27 cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jørgensen, Inger; Chiboucas, Kristin; Schiavon, Ricardo P.

2014-12-01

RX J0848.6+4453 (Lynx W) at redshift 1.27 is part of the Lynx Supercluster of galaxies. We present an analysis of the stellar populations and star formation history for a sample of 24 members of the cluster. Our study is based on deep optical spectroscopy obtained with Gemini North combined with imaging data from Hubble Space Telescope. Focusing on the 13 bulge-dominated galaxies for which we can determine central velocity dispersions, we find that these show a smaller evolution with redshift of sizes and velocity dispersions than reported for field galaxies and galaxies in poorer clusters. Our data show that themore » galaxies in RX J0848.6+4453 populate the fundamental plane (FP) similar to that found for lower-redshift clusters. The zero-point offset for the FP is smaller than expected if the cluster's galaxies are to evolve passively through the location of the FP we established in our previous work for z = 0.8-0.9 cluster galaxies and then to the present-day FP. The FP zero point for RX J0848.6+4453 corresponds to an epoch of last star formation at z{sub form}=1.95{sub −0.15}{sup +0.22}. Further, we find that the spectra of the galaxies in RX J0848.6+4453 are dominated by young stellar populations at all galaxy masses and in many cases show emission indicating low-level ongoing star formation. The average age of the young stellar populations as estimated from the strength of the high-order Balmer line Hζ is consistent with a major star formation episode 1-2 Gyr prior, which in turn agrees with z {sub form} = 1.95. These galaxies dominated by young stellar populations are distributed throughout the cluster. We speculate that low-level star formation has not yet been fully quenched in the center of this cluster, possibly because the cluster is significantly poorer than other clusters previously studied at similar redshifts, which appear to have very little ongoing star formation in their centers. The mixture in RX J0848.6+4453 of passive galaxies with young stellar populations and massive galaxies still experiencing some star formation appears similar to the galaxy populations recently identified in two z ≈ 2 clusters.« less

Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK data 2002-2011. Part II: concomitant reactions.

PubMed

Geier, Johannes; Lessmann, Holger; Hillen, Uwe; Skudlik, Christoph; Jappe, Uta

2016-02-01

Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERSs). Because of chemical similarities, immunological cross-reactivity may occur. To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERSs (FP-0324). A retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2002-2011, was performed. There was close concomitant reactivity to 1,6-hexanediol diglycidyl ether and 1,4-butanediol diglycidyl ether (1,4-BDDGE), and to phenyl glycidyl ether (PGE) and cresyl glycidyl ether (CGE), whereas reactions to p-tert-butylphenyl glycidyl ether occurred more independently from those to PGE and CGE. Concomitant reactions to butyl glycidyl ether and 1,4-BDDGE may point to a common allergenic compound derived from the metabolism of 1,4-BDDGE. Among the structurally more diverse group of hardeners, there was no evidence of immunological cross-reactions. More detailed knowledge of cross-reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERSs to be composed in the future. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

High-resolution motion compensated MRA in patients with congenital heart disease using extracellular contrast agent at 3 Tesla

PubMed Central

2012-01-01

Background Using first-pass MRA (FP-MRA) spatial resolution is limited by breath-hold duration. In addition, image quality may be hampered by respiratory and cardiac motion artefacts. In order to overcome these limitations an ECG- and navigator-gated high-resolution-MRA sequence (HR-MRA) with slow infusion of extracellular contrast agent was implemented at 3 Tesla for the assessment of congenital heart disease and compared to standard first-pass-MRA (FP-MRA). Methods 34 patients (median age: 13 years) with congenital heart disease (CHD) were prospectively examined on a 3 Tesla system. The CMR-protocol comprised functional imaging, FP- and HR-MRA, and viability imaging. After the acquisition of the FP-MRA sequence using a single dose of extracellular contrast agent the motion compensated HR-MRA sequence with isotropic resolution was acquired while injecting the second single dose, utilizing the timeframe before viability imaging. Qualitative scores for image quality (two independent reviewers) as well as quantitative measurements of vessel sharpness and relative contrast were compared using the Wilcoxon signed-rank test. Quantitative measurements of vessel diameters were compared using the Bland-Altman test. Results The mean image quality score revealed significantly better image quality of the HR-MRA sequence compared to the FP-MRA sequence in all vessels of interest (ascending aorta (AA), left pulmonary artery (LPA), left superior pulmonary vein (LSPV), coronary sinus (CS), and coronary ostia (CO); all p < 0.0001). In comparison to FP-MRA, HR-MRA revealed significantly better vessel sharpness for all considered vessels (AA, LSPV and LPA; all p < 0.0001). The relative contrast of the HR-MRA sequence was less compared to the FP-MRA sequence (AA: p <0.028, main pulmonary artery: p <0.004, LSPV: p <0.005). Both, the results of the intra- and interobserver measurements of the vessel diameters revealed closer correlation and closer 95 % limits of agreement for the HR-MRA. HR-MRA revealed one additional clinical finding, missed by FP-MRA. Conclusions An ECG- and navigator-gated HR-MRA-protocol with infusion of extracellular contrast agent at 3 Tesla is feasible. HR-MRA delivers significantly better image quality and vessel sharpness compared to FP-MRA. It may be integrated into a standard CMR-protocol for patients with CHD without the need for additional contrast agent injection and without any additional examination time. PMID:23107424

A new way of controlling NesCOPOs (nested cavity doubly resonant OPO) for faster and more efficient high resolution spectrum measurement

NASA Astrophysics Data System (ADS)

Georges des Aulnois, Johann; Szymanski, Benjamin; Grimieau, Axel; Sillard, Léo.

2018-02-01

Optical Parametric Oscillator (OPO) is a well-known solution when wide tunability in the mid-infrared is needed. A specific design called NesCOPO (Nested Cavity doubly resonant OPO) is currently integrated in the X-FLR8 portable gas analyzer from Blue Industry and Science. Thanks to its low threshold this OPO can be pumped by a micro-chip nanosecond YAG (4 kHz repetition rate and a 30 GHz bandwidth). To achieve very high resolution spectra (10 pm of resolution or better), the emitted wavelength has to be finely controlled. Commercial Wavemeter do not meet price and compactness required in the context of an affordable and portable gas analyzer. To overcome this issue, Blue first integrated an active wavelength controller using multiple tunable Fabry-Perot (FP) interferometers. The required resolution was achieved at a 10 Hz measurement rate. We now present an enhanced Wavemeter architecture, based on fixed FP etalons, that is 100 times faster and 2 times smaller. We avoid having FP `blind zones' thanks to one source characteristic: the knowledge of the FSR (Free Spectral Range) of the OPO source and thus, the fact that only discrete wavelengths can be emitted. First results are displayed showing faster measurement for spectroscopic application, and potential future improvement of the device are discussed.

Pakistan's maternal and child health policy: analysis, lessons and the way forward.

PubMed

Siddiqi, S; Haq, I U; Ghaffar, A; Akhtar, T; Mahaini, R

2004-07-01

An estimated 400,000 infant and 16,500 maternal deaths occur annually in Pakistan. These translate into an infant mortality rate and maternal mortality ratio that should be unacceptable to any state. Disease states including communicable diseases and reproductive health (RH) problems, which are largely preventable account for over 50% of the disease burden. The analysis of Pakistan's maternal and child health (MCH) and family planning (FP) policy covers the period 1990-2002, and focuses on macroeconomic influences, priority programs and gaps, adequacy of resources, equity and organizational aspects, and the process of policy formulation. The overall MCH/FP policy is well directed. MCH/FP has been a priority in all policies; resource allocation, although unacceptably low, has substantially increased during the last decade; and there is a progressive shift from MCH to the reproductive health (RH) agenda. Areas in need of improvement include greater use of evidence as a basis for policy; increased priority to nutrition programs, measures to reduce neonatal and perinatal mortality, provision of emergency obstetric care, availability of skilled birth attendants, and a clear policy on integrated management of childhood illnesses. Enhanced planning capacity, development of a balanced human resource, improved governance to reduce staff absenteeism and frequent transfers, and a greater role of the private sector in the provision of services are some organizational aspects that need the governments' consideration. There are several lessons to be learnt: (i) Ministries of Health need sustained stewardship and well-documented evidence to protect cuts in resource allocation; (ii) frequent policy announcement sends inappropriate signals to managers and weakens on-going implementation; (iii) MCH/FP policies unless informed by evidence and participation of interest groups are unlikely to address gaps in programs; (iv) distributional and equity objectives of MCH/FP be addressed while setting overall national goals; (v) institutional capacity is a vital ingredient in translating MCH/FP policies into effective services. The suggested strategic directions emphasize, among others, the need for a comprehensive MCH/FP framework; strengthened stewardship in ministry of health, cost-effective strategies to address the gaps identified and doubling of the public sector resource allocation to MCH/FP over the next 5 years. The ability to ensure delivery of quality health services remains the biggest challenge in the Pakistani health sector. Unless sound policies are backed by well-functioning programs they are likely to become a victim of poor implementation.

ELSA- The European Levitated Spherical Actruator

NASA Astrophysics Data System (ADS)

Ruiz, M.; Serin, J.; Telteu-Nedelcu, D.; De La Vallee Poussin, H.; Onillon, E.; Rossini, L.

2014-08-01

The reaction sphere is a magnetic bearing spherical actuator consisting of a permanent magnet spherical rotor that can be accelerated in any direction. It consists of an 8-pole permanent magnet spherical rotor that is magnetically levitated and can be accelerated about any axis by a 20-pole stator with electromagnets. The spherical actuator is proposed as a potential alternative to traditional momentum exchange devices such as reaction wheels (RWs) or control moment gyroscopes (CMGs). This new actuator provides several benefits such as reduced mass and power supply allocated to the attitude and navigation unit, performance gain, and improved reliability due to the absence of mechanical bearings. The paper presents the work done on the levitated spherical actuator and more precisely the electrical drive including its control unit and power parts. An elegant breadboard is currently being manufactured within the frame of an FP7 project. This project also comprises a feasibility study to show the feasibility of integrating such a system on a flight platform and to identify all the challenges to be solved in terms of technology or components to be developed.

Teenagers and young adults with cancer in Europe: from national programmes to a European integrated coordinated project.

PubMed

Stark, D; Bielack, S; Brugieres, L; Dirksen, U; Duarte, X; Dunn, S; Erdelyi, D J; Grew, T; Hjorth, L; Jazbec, J; Kabickova, E; Konsoulova, A; Kowalczyk, J R; Lassaletta, A; Laurence, V; Lewis, I; Monrabal, A; Morgan, S; Mountzios, G; Olsen, P R; Renard, M; Saeter, G; van der Graaf, W T; Ferrari, A

2016-05-01

Over 14 000 patients aged 15-24 are estimated to be diagnosed with cancer in the European Union (EU) each year. Teenagers and young adults (TYA) often fall down gaps between children's and adults cancer services. The specific challenges of providing optimal care to them are described, but we present a summary of recent progress. Progress to overcome these challenges is happening at different rates across Europe. We summarise the European national projects in this field but more recently we have seen the beginnings of European coordination. Within the EU 7th Funding Programme (FP7) European Network for Cancer Research in Children and Adolescents programme (ENCCA), a specific European Network for Teenagers and Young Adults with Cancer has held a series of scientific meetings, including professionals, patients and caregivers. This group has proposed unanswered research questions and agreed key features of a high-quality service that can improve outcomes for TYA with cancer, including the primacy of collaboration between adult and paediatric services to eliminate the gap in the management of TYA with cancer. © 2015 John Wiley & Sons Ltd.

Integration of fringe projection and two-dimensional digital image correlation for three-dimensional displacements measurements

NASA Astrophysics Data System (ADS)

Felipe-Sesé, Luis; López-Alba, Elías; Siegmann, Philip; Díaz, Francisco A.

2016-12-01

A low-cost approach for three-dimensional (3-D) full-field displacement measurement is applied for the analysis of large displacements involved in two different mechanical events. The method is based on a combination of fringe projection and two-dimensional digital image correlation (DIC) techniques. The two techniques have been employed simultaneously using an RGB camera and a color encoding method; therefore, it is possible to measure in-plane and out-of-plane displacements at the same time with only one camera even at high speed rates. The potential of the proposed methodology has been employed for the analysis of large displacements during contact experiments in a soft material block. Displacement results have been successfully compared with those obtained using a 3D-DIC commercial system. Moreover, the analysis of displacements during an impact test on a metal plate was performed to emphasize the application of the methodology for dynamics events. Results show a good level of agreement, highlighting the potential of FP + 2D DIC as low-cost alternative for the analysis of large deformations problems.

The low-dose (1 microg) cosyntropin test (LDT) for primary adrenocortical insufficiency: Defining the normal cortisol response and report on first patients with Addison disease confirmed with LDT.

PubMed

Pura, M; Kreze, A; Kentos, P; Vanuga, P

2010-03-01

The validity of low-dose 1 microg cosyntropin test (LDT) is reported mainly for the assessment of secondary adrenocortical insufficiency (AI). Likewise the hypothalamic-pituitary disorders, early diagnosis of the initial or partial stages of primary AI has an important role. The aim of study was to: 1) establish the normal cut-off level at which the stimulated plasma cortisol (FP) in LDT excludes primary AI; 2) compare the results in elderly subjects to those in younger ones; 3) compare the results between normal and obese subjects; and 4) verify the established cut-off values on the sample of patients suspected to have primary AI. 110 subjects (99 women and 11 men, aged 19-80 years, mean 46.2+/-16.1 years, without suspicion for impairment of the hypothalamo-pituitary-adrenal axis were recruited to undergo the LDT in standard conditions. Control group consists of 30 patients (22 women and 8 men, aged 7-58 years, mean 38.4+/-10.6 years) evaluated in whom for suspicion of primary AI as suggested by LDT was confirmed by supplemental investigations (elevated ACTH levels, positive autoantibodies against 21-hydroxylase, mutational analysis of corresponding genes). The mean peak FP level at 30 min (FP (30)) of the subjects was 675+/-85 nmol/L (95% CI=659 to 691 nmol/L), thus reference values expressed as mean+/-2 SD were 505-845 nmol/L. There was a significant negative correlation between basal FP values (FP (0)) (434+/-105 nmol/L) and the absolute FP incremental (FP (Delta)) response varying from 52 to 553 nmol/L (median 230 nmol/L) (r=-0.71; P<0.001). FP (30) was higher in elderly subjects (n=27) in comparison to younger subjects (n=25) (689+/-88 nmol/L vs. 642+/-63 nmol/L, u=2.11, P<0.05) due to higher FP (Delta) (274+/-116 nmol/L vs. 175+/-112 nmol/L; u=4.02, P<0.01) ; FP (30) levels in obese subjects (n=27) did not differ from those with normal BMI (n=33) (694+/-100 nmol/L vs. 667+/-65 nmol/L, u=1.31, P>0.05). We did not find any correlation between body weight or body surface area and FP (0), FP (30) or FP (Delta). Post-stimulation FP (30) levels in the control group varied from 0 to 354 nmol/L with median 64 nmol/L (25 (th) percentile 10 nmol/L; 75 (th) percentile 165 nmol/L) and were entirely distinctive from those of the subjects without adrenal impairment ( P<0.001). Taking the mean -2 SD result as a threshold, FP value of 500 nmol/L can be consider as cut-off at 30 min in the LDT for defining the intact adrenocortical function, independently of age and body weight, body surface area. J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart * New York.

^2H(^18F,p)^19F Study at 6 MeV/u

NASA Astrophysics Data System (ADS)

Kozub, R. L.; Nesaraja, C. D.; Moazen, B. H.; Scott, J. P.; Bardayan, D. W.; Blackmon, J. C.; Gross, C. J.; Shapira, D.; Smith, M. S.; Batchelder, J. C.; Brune, C. R.; Champagne, A. E.; Sahin, L.; Cizewski, J. A.; Thomas, J. S.; Davinson, T.; Woods, P. J.; Greife, U.; Jewett, C.; Livesay, R. J.; Ma, Z.; Parker, P. D.

2003-04-01

The degree to which the (p,α) and (p,γ) reactions destroy ^18F at temperatures ˜1-4 x 10^8 K is important for understanding the synthesis of nuclei in nova explosions and for using ^18F as a monitor of nova mechanisms in gamma ray astronomy. The reactions are dominated by low-lying proton resonances near the ^18F+p threshold (E_x=6.411 MeV excitation energy in ^19Ne). To gain further information about these resonances, we have used the inverse ^18F(d,p)^19F neutron transfer reaction at the Holifield Radioactive Ion Beam Facility to selectively populate corresponding mirror states in ^19F. Proton angular distributions were measured for states in ^19F in the excitation energy range 0-9 MeV. Results and implications for the ^18F+p reactions and nuclear structure will be presented. ^1Supported by DOE. ^2ORNL is managed by UT-Battelle, LLC, for the USDOE.

Influence of primary care professionals on early detection of breast cancer: different perception between family physicians and nursing professionals.

PubMed

Esteban-Vasallo, María D; Aerny-Perreten, Nicole; García-Riolobos, Carmen; López Rubio, Aranzazu; Domínguez-Berjón, Felicitas

2017-01-01

The aim of this study was to assess the level of self-perceived influence on early detection of breast cancer among nurses and family physicians (FP) working in primary care and to identify the factors associated with a lower perception in each group. In the Autonomous Community of Madrid, an online questionnaire on cancer prevention was sent to a random sample of primary care professionals (3586 FP and nurses). The data included sex, age, profession, years in primary care, specific postgraduate training, and opinions and attitudes toward cancer prevention. A descriptive analysis was carried out. Factors associated with a low/null self-perceived influence on early detection of breast cancer were analyzed separately for FP and nurses with multivariate logistic regression models. In all, 76.4% of the participants considered that their influence on the early detection of breast cancer was enough/high. FP attributed to themselves a higher influence than nurses (enough/high: 86.0 vs. 64.6%, P<0.01), and a lower perception was associated with a low/null perceived utility of their individual intervention [odds ratio (OR): 6.42, 95% confidence interval (CI) 2.77-14.85]. Among nurses, also associated with this low/null perceived utility [adjusted odds ratio (aOR): 2.81, 95% CI 1.37-5.77] were the absence of postgraduate training in the matter (aOR: 2.56, 95% CI 1.05-6.25), and a low/null perception of feasibility of prevention programs in their centers (aOR: 1.93, 95% CI 1.25-2.98). Primary care professionals perceive their activity in the early detection of breast cancer as relevant, especially FP. To increase knowledge of the utility of individual interventions, specific training and improvement of the feasibility of these programs could enhance this perception.

The effect of pre- and probiotics on the colonic ammonia metabolism in humans as measured by lactose-[¹⁵N₂]ureide.

PubMed

Wutzke, K D; Lotz, M; Zipprich, C

2010-10-01

The evaluation of ammonia detoxification by pre- and probiotics by means of colonic lactose-[(15)N(2)]ureide ((15)N-LU) degradation is of great interest both scientifically and in terms of nutrition physiology. Pre- and probiotics were supplemented in healthy adults to evaluate the effect of the ammonia metabolism in the human colon by means of (15)N-LU. A total of 14 participants aged 20-28 years daily received a regular diet either without (no treatment) or with supplementation of 30 g fibre of potatoes (FPs), 30 g wrinkle pea starch (WPS, resistant starch content: 12 and 70%, respectively) and 375 g Lactobacillus acidophilus (LC1) yoghurt, over a 10-day period in a randomised order. After 1 week, 5.7 mg/kg body weight (15)N-LU was administered together with breakfast. A venous blood sample was taken after 6 h. Urine and faeces were collected over a period of 48 and 72 h, respectively. The (15)N abundances were measured by isotope ratio mass spectrometry. The mean renal (15)N-excretion differed significantly between the supplementation of FP and no treatment (32.5 versus 46.3%, P=0.034), FP and LC1 (32.5 versus 51.6%, P=0.001), and WPS and LC1 (38.5 versus 51.6%, P=0.048). The mean faecal (15)N-excretion amounted to 42.7% (no treatment), 59.7% (FP), 41.8% (WPS) and 44.0% (LC1). In comparison with no treatment, the urinary (15)NH(3)-enrichment was significantly decreased at 16 h after FP supplementation. The prebiotic intake of FP and WPS lowered the colonic generation and the renal excretion of toxic (15)NH(3), respectively, when using (15)N-LU as a xenobiotic marker.

Nitrogen losses and greenhouse gas emissions under different N and water management in a subtropical double-season rice cropping system.

PubMed

Liang, Kaiming; Zhong, Xuhua; Huang, Nongrong; Lampayan, Rubenito M; Liu, Yanzhuo; Pan, Junfeng; Peng, Bilin; Hu, Xiangyu; Fu, Youqiang

2017-12-31

Nitrogen non-point pollution and greenhouse gas (GHG) emission are major challenges in rice production. This study examined options for both economic and environmental sustainability through optimizing water and N management. Field experiments were conducted to examine the crop yields, N use efficiency (NUE), greenhouse gas emissions, N losses under different N and water management. There were four treatments: zero N input with farmer's water management (N0), farmer's N and water management (FP), optimized N management with farmer's water management (OPT N ) and optimized N management with alternate wetting and drying irrigation (OPT N +AWD). Grain yields in OPT N and OPT N +AWD treatments increased by 13.0-17.3% compared with FP. Ammonia volatilization (AV) was the primary pathway for N loss for all treatments and accounted for over 50% of the total losses. N losses mainly occurred before mid-tillering. N losses through AV, leaching and surface runoff in OPT N were reduced by 18.9-51.6% compared with FP. OPT N +AWD further reduced N losses from surface runoff and leaching by 39.1% and 6.2% in early rice season, and by 46.7% and 23.5% in late rice season, respectively, compared with OPT N . The CH 4 emissions in OPT N +AWD were 20.4-45.4% lower than in OPT N and FP. Total global warming potential of CH 4 and N 2 O was the lowest in OPT N +AWD. On-farm comparison confirmed that N loss through runoff in OPT N +AWD was reduced by over 40% as compared with FP. OPT N and OPT N +AWD significantly increased grain yield by 6.7-13.9%. These results indicated that optimizing water and N management can be a simple and effective approach for enhancing yield with reduced environmental footprints. Copyright © 2017. Published by Elsevier B.V.

Generation of field potentials and modulation of their dynamics through volume integration of cortical activity.

PubMed

Kajikawa, Yoshinao; Schroeder, Charles E

2015-01-01

Field potentials (FPs) recorded within the brain, often called "local field potentials" (LFPs), are useful measures of net synaptic activity in a neuronal ensemble. However, due to volume conduction, FPs spread beyond regions of underlying synaptic activity, and thus an "LFP" signal may not accurately reflect the temporal patterns of synaptic activity in the immediately surrounding neuron population. To better understand the physiological processes reflected in FPs, we explored the relationship between the FP and its membrane current generators using current source density (CSD) analysis in conjunction with a volume conductor model. The model provides a quantitative description of the spatiotemporal summation of immediate local and more distant membrane currents to produce the FP. By applying the model to FPs in the macaque auditory cortex, we have investigated a critical issue that has broad implications for FP research. We have shown that FP responses in particular cortical layers are differentially susceptible to activity in other layers. Activity in the supragranular layers has the strongest contribution to FPs in other cortical layers, and infragranular FPs are most susceptible to contributions from other layers. To define the physiological processes generating FPs recorded in loci of relatively weak synaptic activity, strong effects produced by synaptic events in the vicinity have to be taken into account. While outlining limitations and caveats inherent to FP measurements, our results also suggest specific peak and frequency band components of FPs can be related to activity in specific cortical layers. These results may help improving the interpretability of FPs. Copyright © 2015 the American Physiological Society.

Generation of field potentials and modulation of their dynamics through volume integration of cortical activity

PubMed Central

Schroeder, Charles E.

2014-01-01

Field potentials (FPs) recorded within the brain, often called “local field potentials” (LFPs), are useful measures of net synaptic activity in a neuronal ensemble. However, due to volume conduction, FPs spread beyond regions of underlying synaptic activity, and thus an “LFP” signal may not accurately reflect the temporal patterns of synaptic activity in the immediately surrounding neuron population. To better understand the physiological processes reflected in FPs, we explored the relationship between the FP and its membrane current generators using current source density (CSD) analysis in conjunction with a volume conductor model. The model provides a quantitative description of the spatiotemporal summation of immediate local and more distant membrane currents to produce the FP. By applying the model to FPs in the macaque auditory cortex, we have investigated a critical issue that has broad implications for FP research. We have shown that FP responses in particular cortical layers are differentially susceptible to activity in other layers. Activity in the supragranular layers has the strongest contribution to FPs in other cortical layers, and infragranular FPs are most susceptible to contributions from other layers. To define the physiological processes generating FPs recorded in loci of relatively weak synaptic activity, strong effects produced by synaptic events in the vicinity have to be taken into account. While outlining limitations and caveats inherent to FP measurements, our results also suggest specific peak and frequency band components of FPs can be related to activity in specific cortical layers. These results may help improving the interpretability of FPs. PMID:25274348

SU-C-207-04: Reconstruction Artifact Reduction in X-Ray Cone Beam CT Using a Treatment Couch Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lasio, G; Hu, E; Zhou, J

2015-06-15

Purpose: to mitigate artifacts induced by the presence of the RT treatment couch in on-board CBCT and improve image quality Methods: a model of a Varian IGRT couch is constructed using a CBCT scan of the couch in air. The model is used to generate a set of forward projections (FP) of the treatment couch at specified gantry angles. The model couch forward projections are then used to process CBCT scan projections which contain the couch in addition to the scan object (Catphan phantom), in order to remove the attenuation component of the couch at any given gantry angle. Priormore » to pre-processing with the model FP, the Catphan projection data is normalized to an air scan with bowtie filter. The filtered Catphan projections are used to reconstruct the CBCT with an in-house FDK algorithm. The artifact reduction in the processed CBCT scan is assessed visually, and the image quality improvement is measured with the CNR over a few selected ROIs of the Catphan modules. Results: Sufficient match between the forward projected data and the x-ray projections is achieved to allow filtering in attenuation space. Visual improvement of the couch induced artifacts is achieved, with a moderate expense of CNR. Conclusion: Couch model-based correction of CBCT projection data has a potential for qualitative improvement of clinical CBCT scans, without requiring position specific correction data. The technique could be used to produce models of other artifact inducing devices, such as immobilization boards, and reduce their impact on patient CBCT images.« less

Interdisciplinary assessment of sea-level rise and climate change impacts on the lower Nile delta, Egypt.

PubMed

Sušnik, Janez; Vamvakeridou-Lyroudia, Lydia S; Baumert, Niklas; Kloos, Julia; Renaud, Fabrice G; La Jeunesse, Isabelle; Mabrouk, Badr; Savić, Dragan A; Kapelan, Zoran; Ludwig, Ralf; Fischer, Georg; Roson, Roberto; Zografos, Christos

2015-01-15

CLImate-induced changes on WAter and SECurity (CLIWASEC) was a cluster of three complementary EC-FP7 projects assessing climate-change impacts throughout the Mediterranean on: hydrological cycles (CLIMB - CLimate-Induced changes on the hydrology of Mediterranean Basins); water security (WASSERMed - Water Availability and Security in Southern EuRope and the Mediterranean) and human security connected with possible hydro-climatic conflicts (CLICO - CLImate change hydro-COnflicts and human security). The Nile delta case study was common between the projects. CLIWASEC created an integrated forum for modelling and monitoring to understand potential impacts across sectors. This paper summarises key results from an integrated assessment of potential challenges to water-related security issues, focusing on expected sea-level rise impacts by the middle of the century. We use this common focus to illustrate the added value of project clustering. CLIWASEC pursued multidisciplinary research by adopting a single research objective: sea-level rise related water security threats, resulting in a more holistic view of problems and potential solutions. In fragmenting research, policy-makers can fail to understand how multiple issues can materialize from one driver. By combining efforts, an integrated assessment of water security threats in the lower Nile is formulated, offering policy-makers a clearer picture of inter-related issues to society and environment. The main issues identified by each project (land subsidence, saline intrusion - CLIMB; water supply overexploitation, land loss - WASSERMed; employment and housing security - CLICO), are in fact related. Water overexploitation is exacerbating land subsidence and saline intrusion, impacting on employment and placing additional pressure on remaining agricultural land and the underdeveloped housing market. All these have wider implications for regional development. This richer understanding could be critical in making better policy decisions when attempting to mitigate climate and social change impacts. The CLIWASEC clustering offers an encouraging path for the new European Commission Horizon 2020 programme to follow. Copyright © 2014 Elsevier B.V. All rights reserved.

Marinobacter lacisalsi sp. nov., a moderately halophilic bacterium isolated from the saline-wetland wildfowl reserve Fuente de Piedra in southern Spain.

PubMed

Aguilera, Margarita; Jiménez-Pranteda, Maria L; Kharroub, Karima; González-Paredes, Ana; Durban, Juan J; Russell, Nick J; Ramos-Cormenzana, Alberto; Monteoliva-Sánchez, Mercedes

2009-07-01

A Gram-negative, non-spore-forming, motile, moderately halophilic, aerobic, rod-shaped bacterium, designated strain FP2.5(T), was isolated from the inland hypersaline lake Fuente de Piedra, a saline-wetland wildfowl reserve located in the province of Málaga in southern Spain. Strain FP2.5(T) was subjected to a polyphasic taxonomic study. It produced colonies with a light-yellow pigment. Strain FP2.5(T) grew at salinities of 3-15 % (w/v) and at temperatures of 20-40 degrees C. The pH range for growth was 5-9. Strain FP2.5(T) was able to utilize various organic acids as sole carbon and energy source. Its major fatty acids were C(16 : 0), C(18 : 1)omega9c and C(16 : 1)omega9c. The DNA G+C content was 58.6 mol%. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain FP2.5(T) appeared to be a member of the genus Marinobacter and clustered closely with the type strains of Marinobacter segnicrescens, Marinobacter bryozoorum and Marinobacter gudaonensis (levels of 16S rRNA gene sequence similarity of 98.1, 97.4 and 97.2 %, respectively). However, DNA-DNA relatedness between the new isolate and the type strains of its closest related Marinobacter species was low; levels of DNA-DNA relatedness between strain FP2.5(T) and M. segnicrescens LMG 23928(T), M. bryozoorum DSM 15401(T) and M. gudaonensis DSM 18066(T) were 36.3, 32.1 and 24.9 %, respectively. On the basis of phenotypic characteristics, phylogenetic analysis and DNA-DNA relatedness data, strain FP2.5(T) is considered to represent a novel species of the genus Marinobacter, for which the name Marinobacter lacisalsi sp. nov. is proposed. The type strain is FP2.5(T) (=CECT 7297(T)=LMG 24237(T)).

Surface tension of phenol-formaldehyde wood adhesives

Treesearch

C. -Y. Hse

1972-01-01

Thirty-six phenol (P) fermaldehyde (F) resins were formulated to complete a factorial arrangement: three NAOH/P molar ratios (0.4, 0.7, and 1.0), three solid contents (37, 40, and 43 percent), and four F/P molar rations (1.6, 1.9, 2.2, and 2.5). Surface tension ranged from 68.4 to 79.9 dynes/cm. and was affected most by NAOH/P ratio, next by F/P ratio, and least by...

Towards Cross-Organizational Innovative Business Process Interoperability Services

NASA Astrophysics Data System (ADS)

Karacan, Ömer; Del Grosso, Enrico; Carrez, Cyril; Taglino, Francesco

This paper presents the vision and initial results of the COIN (FP7-IST-216256) European project for the development of open source Collaborative Business Process Interoperability (CBPip) in cross-organisational business collaboration environments following the Software-as-a-Service Utility (SaaS-U) paradigm.

Automated localisation of Mars rovers using co-registered HiRISE-CTX-HRSC orthorectified images and wide baseline Navcam orthorectified mosaics

NASA Astrophysics Data System (ADS)

Tao, Yu; Muller, Jan-Peter; Poole, William

2016-12-01

We present a wide range of research results in the area of orbit-to-orbit and orbit-to-ground data fusion, achieved within the EU-FP7 PRoVisG project and EU-FP7 PRoViDE project. We focus on examples from three Mars rover missions, i.e. MER-A/B and MSL, to provide examples of a new fully automated offline method for rover localisation. We start by introducing the mis-registration discovered between the current HRSC and HiRISE datasets. Then we introduce the HRSC to CTX and CTX to HiRISE co-registration workflow. Finally, we demonstrate results of wide baseline stereo reconstruction with fixed mast position rover stereo imagery and its application to ground-to-orbit co-registration with HiRISE orthorectified image. We show examples of the quantitative assessment of recomputed rover traverses, and extensional exploitation of the co-registered datasets in visualisation and within an interactive web-GIS.

Nested PCR detection of malaria directly using blood filter paper samples from epidemiological surveys.

PubMed

Li, Peipei; Zhao, Zhenjun; Wang, Ying; Xing, Hua; Parker, Daniel M; Yang, Zhaoqing; Baum, Elizabeth; Li, Wenli; Sattabongkot, Jetsumon; Sirichaisinthop, Jeeraphat; Li, Shuying; Yan, Guiyun; Cui, Liwang; Fan, Qi

2014-05-08

Nested PCR is considered a sensitive and specific method for detecting malaria parasites and is especially useful in epidemiological surveys. However, the preparation of DNA templates for PCR is often time-consuming and costly. A simplified PCR method was developed to directly use a small blood filter paper square (2 × 2 mm) as the DNA template after treatment with saponin. This filter paper-based nested PCR method (FP-PCR) was compared to microscopy and standard nested PCR with DNA extracted by using a Qiagen DNA mini kit from filter paper blood spots of 204 febrile cases. The FP-PCR technique was further applied to evaluate malaria infections in 1,708 participants from cross-sectional epidemiological surveys conducted in Myanmar and Thailand. The FP-PCR method had a detection limit of ~0.2 parasites/μL blood, estimated using cultured Plasmodium falciparum parasites. With 204 field samples, the sensitivity of the FP-PCR method was comparable to that of the standard nested PCR method, which was significantly higher than that of microscopy. Application of the FP-PCR method in large cross-sectional studies conducted in Myanmar and Thailand detected 1.9% (12/638) and 6.2% (66/1,070) asymptomatic Plasmodium infections, respectively, as compared to the detection rates of 1.3% (8/638) and 0.04% (4/1,070) by microscopy. This FP-PCR method was much more sensitive than microscopy in detecting Plasmodium infections. It drastically increased the detection sensitivity of asymptomatic infections in cross-sectional surveys conducted in Thailand and Myanmar, suggesting that this FP-PCR method has a potential for future applications in malaria epidemiology studies.

Paying the Price at the End of Life: A Consideration of Factors that Affect the Profitability of Hospice

PubMed Central

Ettner, Susan L.; Lorenz, Karl A.

2008-01-01

Abstract Objective To evaluate factors that affect the financial performance of hospice. Methods Using the California Office of Statewide Health Planning and Development 2003 survey, we evaluated the organizational attributes, clinical care, and financial performance of 185 operational hospices. As outcomes, we evaluated revenues, costs, and profits per patient and per patient–day, the intensity and skill mix of care, and the provision of charitable and special palliative services. We evaluated regression-adjusted differences by profit status controlling for other organizational features and aggregate patient characteristics. Results Hospices reported median revenue of $6865 per patient and $138 per patient–day (for-profit-not-for profit [FP-NFP] difference −$20, p = 0.045), median cost of $6737 per patient, and $135 per patient–day (FP-NFP difference −$55, p = 0.002), and median pretax profit of $334 per patient and $6 per patient–day (FP-NFP difference $34, p = 0.026). Patients received a median of 29.9 total visits by all providers per patient (FP-NFP difference 8.8 visits, p = 0.010), but there was no difference in total visits per patient–day. A median of 50.8% of all nursing visits were registered nurse (RN) visits (FP-NFP difference −14.1%, p < 0.001). Few hospices provided charity care, and only 4% of hospices reported expenditures on chemotherapy and only 9% on radiation therapy. Conclusions Overall hospice profitability is low. Length of stay is strongly associated with financial performance, and greater FP profitability is related to lower costs. FP hospices also provide less RN care as a proportion of nursing care. Few hospices provide charitable care or special costly services. The relationship of service patterns to patient quality needs to be examined. PMID:18788962

Paying the price at the end of life: a consideration of factors that affect the profitability of hospice.

PubMed

O'Neill, Sean M; Ettner, Susan L; Lorenz, Karl A

2008-09-01

To evaluate factors that affect the financial performance of hospice. Using the California Office of Statewide Health Planning and Development 2003 survey, we evaluated the organizational attributes, clinical care, and financial performance of 185 operational hospices. As outcomes, we evaluated revenues, costs, and profits per patient and per patient-day, the intensity and skill mix of care, and the provision of charitable and special palliative services. We evaluated regression-adjusted differences by profit status controlling for other organizational features and aggregate patient characteristics. Hospices reported median revenue of $6865 per patient and $138 per patient-day (for-profit-not-for profit [FP-NFP] difference -$20, p = 0.045), median cost of $6737 per patient, and $135 per patient-day (FP-NFP difference -$55, p = 0.002), and median pretax profit of $334 per patient and $6 per patient-day (FP-NFP difference $34, p = 0.026). Patients received a median of 29.9 total visits by all providers per patient (FP-NFP difference 8.8 visits, p = 0.010), but there was no difference in total visits per patient-day. A median of 50.8% of all nursing visits were registered nurse (RN) visits (FP-NFP difference -14.1%, p < 0.001). Few hospices provided charity care, and only 4% of hospices reported expenditures on chemotherapy and only 9% on radiation therapy. Overall hospice profitability is low. Length of stay is strongly associated with financial performance, and greater FP profitability is related to lower costs. FP hospices also provide less RN care as a proportion of nursing care. Few hospices provide charitable care or special costly services. The relationship of service patterns to patient quality needs to be examined.

deGradFP: A System to Knockdown GFP-Tagged Proteins.

PubMed

Caussinus, Emmanuel; Affolter, Markus

2016-01-01

Protein depletion by genetic means, in a very general sense including the use of RNA interference [1, 2] or CRISPR/Cas9-based methods, represents a central paradigm of modern biology to study protein functions in vivo. However, acting upstream the proteic level is a limiting factor if the turnover of the target protein is slow or the existing pool of the target protein is important (for instance, in insect embryos, as a consequence of a strong maternal contribution). In order to circumvent these problems, we developed deGradFP [3, 4]. deGradFP harnesses the ubiquitin-proteasome pathway to achieve direct depletion of GFP-tagged proteins. deGradFP is in essence a universal method because it relies on an evolutionarily conserved machinery for protein catabolism in eukaryotic cells; see refs. 5, 6 for review. deGradFP is particularly convenient in Drosophila melanogaster where it is implemented by a genetically encoded effector expressed under the control of the Gal4 system. deGradFP is a ready-to-use solution to perform knockdowns at the protein level if a fly line carrying a functional GFP-tagged version of the gene of interest is available. Many such lines have already been generated by the Drosophila community through different technologies allowing to make genomic rescue constructs or direct GFP knockins: protein-trap stock collections [7, 8] ( http://cooley.medicine.yale.edu/flytrap/ , http://www.flyprot.org/ ), P[acman] system [9], MiMIC lines [10, 11], and CRISPR/Cas9-driven homologous recombination.Two essential controls of a protein knockdown experiment are easily achieved using deGradFP. First, the removal of the target protein can be assessed by monitoring the disappearance of the GFP tag by fluorescence microscopy in parallel to the documentation of the phenotype of the protein knockdown (see Note 1 ). Second, the potential nonspecific effects of deGradFP can be assessed in control fly lacking a GFP-tagged target protein. So far, no nonspecific effects of the deGradFP effector have been reported [3].

Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells.

PubMed

Zhang, Ting; Du, Jiang; Liu, Liguo; Chen, Xiaolan; Yang, Fang; Jin, Qi

2012-01-01

Chrysin and its phosphate ester have previously been shown to inhibit cell proliferation and induce apoptosis in Hela cells; however, the underlying mechanism remains to be characterized. In the present study, we therefore synthesized diethyl flavon-7-yl phosphate (FP, C(19)H(19)O(6)P) by a simplified Atheron-Todd reaction, and explored its anti-tumor characteristics and mechanisms. Cell proliferation, cell cycle progression and apoptosis were measured by MTS, flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling techniques, respectively in human cervical cancer HeLa cells treated with 7-hydroxyflavone (HF) and FP. p21, proliferating cell nuclear antigen (PCNA) and cAMP levels in Hela cells were analyzed by western blot and radioimmunoassay. Both HF and FP inhibited proliferation and induced apoptosis in HeLa cells via induction of PCNA/p21 expression, cleaved caspase-3/poly (ADP-ribose) polymerase (PARP)-1, elevation of cAMP levels, and cell cycle arrest with accumulation of cells in the G0/G1 fraction. The effects of FP were more potent than those of HF. The interactions of FP with Ca(2+)-calmodulin (CaM) and Ca(2+)-CaM-phosphodiesterase (PDE)1 were explored by electrospray ionization-mass spectrometry and fluorescence spectra. FP, but not HF, formed non-covalent complexes with Ca(2+)-CaM-PDE1, indicating that FP is an inhibitor of PDE1, and resulting in elevated cellular cAMP levels. It is possible that the elevated cAMP levels inhibit growth and induce apoptosis in Hela cells through induction of p21 and cleaved caspase-3/PARP-1 expression, and causing down-regulation of PCNA and cell cycle arrest with accumulation of cells in the G0/G1 and G2/M fractions. In conclusion, FP was shown to be a Ca(2+)-CaM-PDE inhibitor, which might account for its underlying anti-cancer mechanism in HeLa cells. These observations clearly demonstrate the special roles of phosphorylated flavonoids in biological processes, and suggest that FP might represent a potential new drug for the therapy of human cervical carcinoma.

Inhibitory Effects and Underlying Mechanism of 7-Hydroxyflavone Phosphate Ester in HeLa Cells

PubMed Central

Liu, Liguo; Chen, Xiaolan; Yang, Fang; Jin, Qi

2012-01-01

Chrysin and its phosphate ester have previously been shown to inhibit cell proliferation and induce apoptosis in Hela cells; however, the underlying mechanism remains to be characterized. In the present study, we therefore synthesized diethyl flavon-7-yl phosphate (FP, C19H19O6P) by a simplified Atheron-Todd reaction, and explored its anti-tumor characteristics and mechanisms. Cell proliferation, cell cycle progression and apoptosis were measured by MTS, flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling techniques, respectively in human cervical cancer HeLa cells treated with 7-hydroxyflavone (HF) and FP. p21, proliferating cell nuclear antigen (PCNA) and cAMP levels in Hela cells were analyzed by western blot and radioimmunoassay. Both HF and FP inhibited proliferation and induced apoptosis in HeLa cells via induction of PCNA/p21 expression, cleaved caspase-3/poly (ADP-ribose) polymerase (PARP)-1, elevation of cAMP levels, and cell cycle arrest with accumulation of cells in the G0/G1 fraction. The effects of FP were more potent than those of HF. The interactions of FP with Ca2+-calmodulin (CaM) and Ca2+-CaM-phosphodiesterase (PDE)1 were explored by electrospray ionization-mass spectrometry and fluorescence spectra. FP, but not HF, formed non-covalent complexes with Ca2+-CaM-PDE1, indicating that FP is an inhibitor of PDE1, and resulting in elevated cellular cAMP levels. It is possible that the elevated cAMP levels inhibit growth and induce apoptosis in Hela cells through induction of p21 and cleaved caspase-3/PARP-1 expression, and causing down-regulation of PCNA and cell cycle arrest with accumulation of cells in the G0/G1 and G2/M fractions. In conclusion, FP was shown to be a Ca2+-CaM-PDE inhibitor, which might account for its underlying anti-cancer mechanism in HeLa cells. These observations clearly demonstrate the special roles of phosphorylated flavonoids in biological processes, and suggest that FP might represent a potential new drug for the therapy of human cervical carcinoma. PMID:22574207

On the socioeconomic benefits of family planning work.

PubMed

Yang, D

1991-01-01

The focus of this article is on 1) the intended socioeconomic benefit of Chinese family planning (FP) versus the benefit of the maternal production sector, 2) the estimated costs of FP work, 3) and the principal ways to lower FP costs. Marxian population theory, which is ascribed to in socialist China, states that population and socioeconomic development are interconnected and must adapt to each other and that an excessively large or small population will upset the balance and retard development. Malthusians believe that large populations reduce income, and Adam Smith believed that more people meant a larger market and more income. It is believed that FP will bring socioeconomic benefits to China. The socioeconomic benefit of material production is the linkage between labor consumption and the amount of labor usage with the fruits and benefits of labor. FP invests in human, material, and financial resources to reduce the birth rate and the absolute number of births. The investment is recouped in population. The increased national income generated from a small outlay to produce an ideal population would be used to improve material and cultural lives. FP brings economic benefits and accelerates social development (ecological balances women's emancipation and improvement in the physical and mental health of women and children, improvement in cultural learning and employment, cultivation of socialist morality and new practices, and stability). In computing FP cost, consideration is given to total cost and unit cost. Cost is dependent on the state budget allocation, which was 445.76 million yuan in 1982 and was doubled by 1989. World Bank figures for 1984 affixed the FP budget in China at 979.6 million US dollars, of which 80% was provided by China. Per person, this means 21 cents for central, provincial, prefecture, and country spending, 34 cents for rural collective set-ups, 25 cents for child awards, and various subsidies, 15 cents for sterilization, and 5 cents for rural medical services, or 1 US dollar/person. Unit costs are the costs to reduce the population of one and include direct and indirect costs. The unit cost between 1970-82 was 35.5 yuan, but if outlays for families and industrial units are included, the cost was 70-100 yuan. Population growth, however, must be balanced so that aging does not cancel out the benefits from FP gains. Lower costs can be achieved by better FP administration.

Fluorescence emission and polarization analyses for evaluating binding of ruthenium metalloglycocluster to lectin and tetanus toxin c-fragment

NASA Astrophysics Data System (ADS)

Okada, Tomoko; Minoura, Norihiko

2010-02-01

We have developed a fluorescent ruthenium metalloglycocluster as a powerful molecular probe for evaluating a binding event between carbohydrates and lectins by fluorescence emission (FE) and fluorescence polarization (FP) analysis. The fluorescent ruthenium metalloglycoclusters, [Ru(bpy-2Gal)3] and [Ru(bpy-2Glc)3], possess clustered galactose and glucose surrounding the ruthenium center. Changes in FE and FP of these metalloglycoclusters were measured by adding each lectin (Peanut agglutinin (PNA), Ricinus communis agglutinin 120 (RCA), Concanavalin A (ConA), or Wheat germ agglutinin (WGA)) or tetanus toxin c-fragment (TCF). Following the addition of PNA, the FE spectrum of [Ru(bpy- 2Gal)3] showed new emission peak and the FP value of [Ru(bpy-2Gal)3] increased. Similarly, the FE spectrum of [Ru(bpy-2Glc)3] showed new emission peak and the FP value increased following the addition of ConA. Since other combinations of the metalloglycoclusters and lectin caused little change, specific bindings of galactose to PNA and glucose to ConA were proved by the FE and FP measurement. From nonlinear least-squares fitting, dissociation constants (Kd) of [Ru(bpy-2Gal)3] to PNA was 6.1 μM, while the Kd values of [Ru(bpy)2(bpy-2Gal)] to PNA was ca. 10-4 M. Therefore, the clustered carbohydrates were proved to increase affinity to lectins. Furthermore, the FP measurements proved specific binding of [Ru(bpy-2Gal)3] to TCF.

Proceedings of the 2015 international summit on fibropapillomatosis: Global status, trends, and population impacts

USGS Publications Warehouse

Hargrove, Stacy A.; Work, Thierry M.; Brunson, Shandell; Foley, Allen M.; Balazs, George H.

2016-01-01

The 2015 International Summit on Fibropapillomatosis (FP) was convened in Honolulu, Hawaii June 11-14, 2015. Scientists from around the world were invited to present results from sea turtle monitoring and research programs as they relate to the global status, trends, and population impacts of FP on green turtles. The participants engaged in discussions that resulted in the following conclusions: 1.Globally, FP has long been present in wild sea turtle populations the earliest mention was in the late 1800s in the Florida Keys. 2.FP primarily affects medium-sized immature turtles in coastal foraging pastures. 3.Expression of FP differs across ocean basins and to some degree within basins. Turtles in the Southeast US, Caribbean, Brazil, and Australia rarely have oral tumors (inside the mouth cavity), whereas they are common and often severe in Hawaii. Internal tumors (on vital organs) occur in the Atlantic and Hawaii, but only rarely in Australia. Liver tumors are common in Florida but not in Hawaii. 4.Recovery from FP through natural processes, when the affliction is not severe, has been documented in wild populations globally. 5.FP causes reduced survivorship, but documented mortality rates in Australia and Hawaii are low. The mortality impact of FP is not currently exceeding population growth rates in some intensively monitored populations (e.g., Florida, Hawaii) as evidenced by increasing nesting trends despite the incidence of FP in immature foraging populations. 6.Pathogens, hosts, and potential disease and environmental cofactors have the capacity to change; while we are having success now, there needs to be continued monitoring to detect changes in the distribution, occurrence, and severity of the disease. 7.While we do not have clear evidence to provide the direct link, globally, the preponderance of sites with a high frequency of FP tumors are areas with some degree of degradation resulting from altered watersheds. Watershed management and responsible coastal development may be the best approach for reducing the spread and prevalence of the disease. 8.Future research efforts should employ a multi-factorial ecological approach (e.g., virology, parasitology, genetics, health, diet, habitat use, water quality, etc.) since there are likely several environmental cofactors involved in the expression of the disease, which is still thought to be caused by a herpesvirus. 9.Minimum FP data collection in new areas should include: individual identification (photo ID, PIT tags, etc.), standard measurements (length and weight), presence/absence of tumors, tumor severity, body condition, oral examination, method of capture, and effort

The ASTARTE Paleotsunami and Mass Transport Deposits data bases - web-based references for tsunami and submarine landslide research around Europe

NASA Astrophysics Data System (ADS)

De Martini, Paolo Marco; Patera, Antonio; Orefice, Simone; Paris, Raphael; Völker, David; Lastras, Galderic; Terrinha, Pedro; Noiva, João; Smedile, Alessandra; Pantosti, Daniela; Hunt, James; Gutscher, Marc-Andre; Migeon, Sébastien; Papadopoulos, Gerassimos; Triantafyllou, Ioanna; Yalciner, Ahmet C.

2017-04-01

EU project ASTARTE aims at developing a higher level of tsunami hazard assessment in the North East Atlantic, Mediterranean and Connected seas (NEAM) region by a combination of field work, experimental work, numerical modeling and technical development. The project is a cooperative work of 26 institutes from 16 countries and links together the description of past tsunamigenic events, the identification and characterization of tsunami sources, the calculation of the impact of such events, and the development of adequate resilience and risks mitigation strategies (www.astarte.eu). Within ASTARTE two web-based data bases on Paleotsunami and Mass Transport Deposits in the NEAM areas were created with the purpose to be the future information repositories for tsunami research in Europe.The aim is to integrate every existing official scientific reports and peer reviewed papers on these topics and update on new entries every 6-12 months, hosting information and detailed data, that are crucial e.g for tsunami modeling. A relational database managed by ArcGIS for Desktop 10.x software has been implemented. One of the final goals of the project is the public sharing of the archived datasets through a web-based map service that will allow visualizing, querying, analyzing, and interpreting all datasets. The interactive map service will be hosted by ArcGIS Online and will deploy the cloud capabilities of the portal. Any interested users will be able to access the online GIS resources through any Internet browser or specific apps that run on desktop machines, smartphones, or tablets and will be able to use the analytical tools, key tasks, and workflows of the service.We will present the data bases structure and topics as well as their ArcGIS Online version. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 603839 (Project ASTARTE - Assessment, Strategy and Risk Reduction for Tsunamis in Europe).

Methodology for qualitative uncertainty assessment of climate impact indicators

NASA Astrophysics Data System (ADS)

Otto, Juliane; Keup-Thiel, Elke; Rechid, Diana; Hänsler, Andreas; Pfeifer, Susanne; Roth, Ellinor; Jacob, Daniela

2016-04-01

The FP7 project "Climate Information Portal for Copernicus" (CLIPC) is developing an integrated platform of climate data services to provide a single point of access for authoritative scientific information on climate change and climate change impacts. In this project, the Climate Service Center Germany (GERICS) has been in charge of the development of a methodology on how to assess the uncertainties related to climate impact indicators. Existing climate data portals mainly treat the uncertainties in two ways: Either they provide generic guidance and/or express with statistical measures the quantifiable fraction of the uncertainty. However, none of the climate data portals give the users a qualitative guidance how confident they can be in the validity of the displayed data. The need for such guidance was identified in CLIPC user consultations. Therefore, we aim to provide an uncertainty assessment that provides the users with climate impact indicator-specific guidance on the degree to which they can trust the outcome. We will present an approach that provides information on the importance of different sources of uncertainties associated with a specific climate impact indicator and how these sources affect the overall 'degree of confidence' of this respective indicator. To meet users requirements in the effective communication of uncertainties, their feedback has been involved during the development process of the methodology. Assessing and visualising the quantitative component of uncertainty is part of the qualitative guidance. As visual analysis method, we apply the Climate Signal Maps (Pfeifer et al. 2015), which highlight only those areas with robust climate change signals. Here, robustness is defined as a combination of model agreement and the significance of the individual model projections. Reference Pfeifer, S., Bülow, K., Gobiet, A., Hänsler, A., Mudelsee, M., Otto, J., Rechid, D., Teichmann, C. and Jacob, D.: Robustness of Ensemble Climate Projections Analyzed with Climate Signal Maps: Seasonal and Extreme Precipitation for Germany, Atmosphere (Basel)., 6(5), 677-698, doi:10.3390/atmos6050677, 2015.

Hypersonic research engine/aerothermodynamic integration model, experimental results. Volume 1: Mach 6 component integration

NASA Technical Reports Server (NTRS)

Andrews, E. H., Jr.; Mackley, E. A.

1976-01-01

The NASA Hypersonic Research Engine (HRE) Project was initiated for the purpose of advancing the technology of airbreathing propulsion for hypersonic flight. A large component (inlet, combustor, and nozzle) and structures development program was encompassed by the project. The tests of a full-scale (18 in. diameter cowl and 87 in. long) HRE concept, designated the Aerothermodynamic Integration Model (AIM), at Mach numbers of 5, 6, and 7. Computer program results for Mach 6 component integration tests are presented.

EUTEMPE-RX, an EC supported FP7 project for the training and education of medical physics experts in radiology.

PubMed

Bosmans, H; Bliznakova, K; Padovani, R; Christofides, S; Van Peteghem, N; Tsapaki, V; Caruana, C J; Vassileva, J

2015-07-01

The core activity of the medical physics expert (MPE) is to ensure optimal use of ionising radiation in healthcare. It is essential that these healthcare professionals are trained to the highest level, defined as European Qualifications Framework for Lifelong Learning (EQF) level 8 by the European Commission's Radiation Protection Report 174 'Guidelines on the MPE'. The main objective of the EUTEMPE-RX project is to provide a model training scheme that allows the medical physicist in diagnostic and interventional radiology (D&IR) to reach this high level. A European network of partners was brought together in this FP7 EC project to ensure sufficient expertise in all aspects of the subject and to create a harmonised course programme. Targeted participants are medical physicists in D&IR in hospitals, engineers and scientists in medical device industries and officers working in regulatory authorities. Twelve course modules will be developed at EQF level 8, with radiation safety and diagnostic effectiveness being prevalent subjects. The modules will combine online with face-to-face teaching using a blended learning approach. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

New amino acid germinants for spores of the enterotoxigenic Clostridium perfringens type A isolates.

PubMed

Udompijitkul, Pathima; Alnoman, Maryam; Banawas, Saeed; Paredes-Sabja, Daniel; Sarker, Mahfuzur R

2014-12-01

Clostridium perfringens spore germination plays a critical role in the pathogenesis of C. perfringens-associated food poisoning (FP) and non-food-borne (NFB) gastrointestinal diseases. Germination is initiated when bacterial spores sense specific nutrient germinants (such as amino acids) through germinant receptors (GRs). In this study, we aimed to identify and characterize amino acid germinants for spores of enterotoxigenic C. perfringens type A. The polar, uncharged amino acids at pH 6.0 efficiently induced germination of C. perfringens spores; L-asparagine, L-cysteine, L-serine, and L-threonine triggered germination of spores of most FP and NFB isolates; whereas, L-glutamine was a unique germinant for FP spores. For cysteine- or glutamine-induced germination, gerKC spores (spores of a gerKC mutant derivative of FP strain SM101) germinated to a significantly lower extent and released less DPA than wild type spores; however, a less defective germination phenotype was observed in gerAA or gerKB spores. The germination defects in gerKC spores were partially restored by complementing the gerKC mutant with a recombinant plasmid carrying wild-type gerKA-KC, indicating that GerKC is an essential GR protein. The gerKA, gerKC, and gerKB spores germinated significantly slower with L-serine and L-threonine than their parental strain, suggesting the requirement for these GR proteins for normal germination of C. perfringens spores. In summary, these results indicate that the polar, uncharged amino acids at pH 6.0 are effective germinants for spores of C. perfringens type A and that GerKC is the main GR protein for germination of spores of FP strain SM101 with L-cysteine, L-glutamine, and L-asparagine. Copyright © 2014 Elsevier Ltd. All rights reserved.

Adjunctive stent use during endovascular intervention to the femoropopliteal artery with drug coated balloons: Insights from the XLPAD registry.

PubMed

Kokkinidis, Damianos G; Jeon-Slaughter, Haekyung; Khalili, Houman; Brilakis, Emmanouil S; Shammas, Nicolas W; Banerjee, Subhash; Armstrong, Ehrin J

2018-06-01

With growing use of drug-coated balloons (DCB) for femoropopliteal (FP) artery interventions, there is limited information on rates of real-world adjunctive stent use and its association with short and long-term outcomes. We report on 225 DCB treated FP lesions in 224 patients from the Excellence in Peripheral Artery Disease (XLPAD) registry (NCT01904851) between 2014 and 2016. Cochran-Mantel-Haenszel and Wilcoxon rank sum statistics were used to compare stented (planned or 'bail-out') versus non-stented DCB treated lesions. Stents were implanted in 31% of FP DCB interventions. Among the 70 stents implanted, 46% were for 'bail-out' indications and 54% were planned. Lesions treated with stents were longer (mean 150 mm vs 100 mm; p < 0.001) and less likely to be in-stent restenosis lesions (10% vs 28%; p=0.003). Stenting was significantly more frequent in complex FP lesions, including chronic total occlusions (66% vs 34%; p < 0.001). For bail-out stenting, interwoven nitinol stents were the most common type (50%) followed by drug-eluting stents (34%) and bare-metal stents (22%). There were no differences in peri-procedural complication rates or 12-month target limb revascularization rates (18.6% vs 11.6%; p=0.162) or 12-month amputation rates (11.4% vs 11%; p=0.92) between lesions where adjunctive stenting was used versus lesions without adjunctive stenting, respectively. In conclusion, in a contemporary 'real-world' adjudicated multicenter US registry, adjunctive stenting was necessary in nearly a third of the lesions, primarily for the treatment of more complex FP lesions, with similar short and intermediate-term clinical outcomes compared with non-stented lesions.

Health Service Utilisation, Detection Rates by Family Practitioners, and Management of Patients with Common Mental Disorders in French Family Practice.

PubMed

Norton, Joanna; Engberink, Agnès Oude; Gandubert, Catherine; Ritchie, Karen; Mann, Anthony; David, Michel; Capdevielle, Delphine

2017-08-01

Provide up-to-date detection rates for common mental disorders (CMD) and examine patient service-use since the Preferred Doctor scheme was introduced to France in 2005, with patients encouraged to register with and consult a family practitioner (FP) of their choice. Study of 1133 consecutive patients consulting 38 FPs in the Montpellier region, replicating a study performed before the scheme. Patients in the waiting room completed the self-report Patient Health Questionnaire (PHQ) and Client Service-Receipt Inventory with questions on registration with a Preferred Doctor and doctor-shopping. CMD was defined as reaching PHQ criteria for depression, somatoform, panic or anxiety disorder. For each patient, FPs completed a questionnaire capturing psychiatric caseness. 81.2% of patients were seeing their Preferred Doctor on the survey-day. Of those with a CMD, 52.6% were detected by the FP. This increased with CMD severity and comorbidity. Detected cases were more likely to be consulting their Preferred Doctor (84.7% versus 79.4% for non-detected cases, p = 0.05) rather than another FP. They declared more visits to psychiatrists (17.2% versus 6.7%, p = 0.002). There was no association with consultation frequency or doctor-shopping, which both declined between the two studies. The CMD detection rate is relatively high, with no increase compared to our previous study, despite a decline in doctor-shopping. An explanation is the same high proportion of patients visiting their usual FP on the survey-day at both periods, suggesting a limited impact of the scheme on care continuity. FP action taken highlights the importance of improving detection for providing care to patients with CMDs.

Health Service Utilisation, Detection Rates by Family Practitioners, and Management of Patients with Common Mental Disorders in French Family Practice

PubMed Central

Engberink, Agnès Oude; Gandubert, Catherine; Ritchie, Karen; Mann, Anthony; David, Michel; Capdevielle, Delphine

2017-01-01

Objective: Provide up-to-date detection rates for common mental disorders (CMD) and examine patient service-use since the Preferred Doctor scheme was introduced to France in 2005, with patients encouraged to register with and consult a family practitioner (FP) of their choice. Methods: Study of 1133 consecutive patients consulting 38 FPs in the Montpellier region, replicating a study performed before the scheme. Patients in the waiting room completed the self-report Patient Health Questionnaire (PHQ) and Client Service-Receipt Inventory with questions on registration with a Preferred Doctor and doctor-shopping. CMD was defined as reaching PHQ criteria for depression, somatoform, panic or anxiety disorder. For each patient, FPs completed a questionnaire capturing psychiatric caseness. Results: 81.2% of patients were seeing their Preferred Doctor on the survey-day. Of those with a CMD, 52.6% were detected by the FP. This increased with CMD severity and comorbidity. Detected cases were more likely to be consulting their Preferred Doctor (84.7% versus 79.4% for non-detected cases, p = 0.05) rather than another FP. They declared more visits to psychiatrists (17.2% versus 6.7%, p = 0.002). There was no association with consultation frequency or doctor-shopping, which both declined between the two studies. Conclusion: The CMD detection rate is relatively high, with no increase compared to our previous study, despite a decline in doctor-shopping. An explanation is the same high proportion of patients visiting their usual FP on the survey-day at both periods, suggesting a limited impact of the scheme on care continuity. FP action taken highlights the importance of improving detection for providing care to patients with CMDs. PMID:28107037

Proposal of a Video-recording System for the Assessment of Bell's Palsy: Methodology and Preliminary Results.

PubMed

Monini, Simonetta; Marinozzi, Franco; Atturo, Francesca; Bini, Fabiano; Marchelletta, Silvia; Barbara, Maurizio

2017-09-01

To propose a new objective video-recording procedure to assess and monitor over time the severity of facial nerve palsy. No objective methods for facial palsy (FP) assessment are universally accepted. The face of subjects presenting with different degrees of facial nerve deficit, as measured by the House-Brackmann (HB) grading system, was videotaped after positioning, at specific points, 10 gray circular markers made of a retroreflective material. Video-recording included the resting position and six ordered facial movements. Editing and data elaboration was performed using a software instructed to assess marker distances. From the differences of the marker distances between the two sides was then extracted a score. The higher the FP degree, the higher the score registered during each movement. The statistical significance differed during the various movements between the different FP degrees, being uniform when closing the eyes gently; whereas when wrinkling the nose, there was no difference between the HB grade III and IV groups and, when smiling, no difference was evidenced between the HB grade IV and V groups.The global range index, which represents the overall degree of FP, was between 6.2 and 7.9 in the normal subjects (HB grade I); between 10.6 and 18.91 in HB grade II; between 22.19 and 33.06 in HB grade III; between 38.61 and 49.75 in HB grade IV; and between 50.97 and 66.88 in HB grade V. The proposed objective methodology could provide numerical data that correspond to the different degrees of FP, as assessed by the subjective HB grading system. These data can in addition be used singularly to score selected areas of the paralyzed face when recovery occurs with a different timing in the different face regions.

Effectiveness of the population health and environment approach in improving family planning outcomes in the Gurage, Zone South Ethiopia.

PubMed

Sinaga, Makeda; Mohammed, Ahmed; Teklu, Negash; Stelljes, Kristen; Belachew, Tefera

2015-11-13

Family planning is a strategy of balancing population growth with economic development for sustainable use of natural resources. A high population growth induces increased demand for resources and the rate at which these resources are exploited. Population, health and environment are connected inextricably. Population growth unbalanced with economic development leads to food insecurity which exposes households to the consumption of food with reduced quality and quantity leading to increased risk of malnutrition and poor health. Food insecurity again obliges people to encroach into the natural environment leading to a spiraling progress to destitution. A study in the Philippines provided concrete evidence that integrated development programming incorporating population, health, and the environment (PHE) can be more effective in lowering population growth rates and preserving critical coastal ecosystems than single-sector development interventions". Although the PHE approach has been implemented for 5 years (2008-2012) Guraghe Zone of South Ethiopia, its outcomes have not been evaluated. The objective of this study was to evaluate the effectiveness of PHE approach for achieving family planning (FP) outcomes in Gurage Zone. A comparative cross-sectional study was conducted in October, 2012. A total of 962 married women in the reproductive age group were included in the study. Data were collected using an interviewer administered Amharic version questionnaire. Descriptive statistics and multivariable logistic regression analyses were performed to compare the PHE and non-PHE Woredas (district) based on family planning parameters adopted from Measure Evaluation Manual. Comparison of non-new family panning acceptor women showed that PHE Woreda had a significantly high CPR compared to non-PHE (78% vs 52%, P < 0.0001). Among these sub-groups, women in the PHE Woreda were over four times more likely to use family planning methods during the study period (P < 0.0001) compared with women in the non-PHE Woreda. Women whose husbands' supported their use of family planning methods were 17 times as likely to use family panning methods (AOR: 17.2, 95 % CI [11.1, 26.8]), P < 0.0001. This was even increased to 20 times more when we did sub-group analysis only for women who were not new acceptors (AOR: 20.4:95% CI [9.7, 42.7]), P < 0.0001. The qualitative results showed that there was a better integration of FP, health and environmental issues into the grassroots level interventions in the PHE Woreda through using students as a medium for reaching parents on family planning and environmental issues. The findings suggest that overall; PHE has positive outcomes in FP behaviors both among married women and their husbands. Integration of population, health and environmental issues need to be strengthened and scaled up to sustain the positive FP behaviors such as support of FP use. Strategies used in the PHE Woredas such as using schools and students as medium for integrated PHE interventions are commendable approaches that need to be strengthened.

Development of Realistic Striatal Digital Brain (SDB) Phantom for 123I-FP-CIT SPECT and Effect on Ventricle in the Brain for Semi-quantitative Index of Specific Binding Ratio.

PubMed

Furuta, Akihiro; Onishi, Hideo; Nakamoto, Kenta

This study aimed at developing the realistic striatal digital brain (SDB) phantom and to assess specific binding ratio (SBR) for ventricular effect in the 123 I-FP-CIT SPECT imaging. SDB phantom was constructed in to four segments (striatum, ventricle, brain parenchyma, and skull bone) using Percentile method and other image processing in the T2-weighted MR images. The reference image was converted into 128×128 matrixes to align MR images with SPECT images. The process image was reconstructed with projection data sets generated from reference images additive blurring, attenuation, scatter, and statically noise. The SDB phantom was evaluated to find the accuracy of calculated SBR and to find the effect of SBR with/without ventricular counts with the reference and process images. We developed and investigated the utility of the SDB phantom in the 123 I-FP-CIT SPECT clinical study. The true value of SBR was just marched to calculate SBR from reference and process images. The SBR was underestimated 58.0% with ventricular counts in reference image, however, was underestimated 162% with ventricular counts in process images. The SDB phantom provides an extremely convenient tool for discovering basic properties of 123 I-FP-CIT SPECT clinical study image. It was suggested that the SBR was susceptible to ventricle.

Hatfield Marine Science Center Dynamic Revetment Project DSL permit #45455-FP, Monitoring Report February 2012

EPA Science Inventory

A Dynamic Revetment (gravel beach) was installed in November, 2011 on the shoreline along the northeastern edge of the Hatfield Marine Science Center (HMSC) to mitigate erosion that threatened HMSC critical infrastructure. Shoreline topographic and biological monitoring was init...

Hatfield Marine Science Center Dynamic Revetment Project DSL permit #45455-FP, Monitoring Report February, 2013

EPA Science Inventory

A Dynamic Revetment (gravel beach) was installed in November, 2011 on the shoreline along the northeastern edge of the Hatfield Marine Science Center (HMSC) to mitigate erosion that threatened HMSC critical infrastructure. Shoreline topographic and biological monitoring was init...

Swept optical SSB-SC modulation technique for high-resolution large-dynamic-range static strain measurement using FBG-FP sensors.

PubMed

Huang, Wenzhu; Zhang, Wentao; Li, Fang

2015-04-01

This Letter presents a static strain demodulation technique for FBG-FP sensors using a suppressed carrier LiNbO(3) (LN) optical single sideband (SSB-SC) modulator. A narrow-linewidth tunable laser source is generated by driving the modulator using a linear chirp signal. Then this tunable single-frequency laser is used to interrogate the FBG-FP sensors with the Pound-Drever-Hall (PDH) technique, which is beneficial to eliminate the influence of light intensity fluctuation of the modulator at different tuning frequencies. The static strain is demodulated by calculating the wavelength difference of the PDH signals between the sensing FBG-FP sensor and the reference FBG-FP sensor. As an experimental result using the modulator, the linearity (R²) of the time-frequency response increases from 0.989 to 0.997, and the frequency-swept range (dynamic range) increases from hundreds of MHz to several GHz compared with commercial PZT-tunable lasers. The high-linearity time-wavelength relationship of the modulator is beneficial for improving the strain measurement resolution, as it can solve the problem of the frequency-swept nonlinearity effectively. In the laboratory test, a 0.67 nanostrain static strain resolution, with a 6 GHz dynamic range, is demonstrated.

Impact of fowlpox-vectored Mycoplasma gallisepticum vaccine Vectormune FP MG on layer hen egg production and egg quality parameters.

PubMed

Leigh, S A; Branton, S L; Evans, J D; Collier, S D

2013-12-01

This study was conducted to determine the impact of vaccination with Vectormune FP MG on egg production and egg quality characteristics of Single Comb White Leghorn hens. Due to questions of the efficacy of this vaccine in preventing Mycoplasma gallisepticum-mediated pathology, the ability of this vaccine to protect against postproduction-peak egg losses associated with F-strain M. gallisepticum (FMG) vaccination was also investigated. Vaccination with Vectormune FP MG did not result in any significant change in egg production or egg quality parameters compared with control (unvaccinated) hens. Subsequent revaccination with FMG at 45 wk of age (woa) yielded no impact on egg production or egg quality parameters of Vectormune FP MG vaccinated hens, unlike prior results for postproduction-peak vaccination of M. gallisepticum-clean hens with FMG, which exhibited a drop in egg production of approximately 6%. No difference in egg size distribution was observed for any of the treatment groups before or after FMG revaccination. These results suggest that hens can be safely vaccinated with Vectormune FP MG as pullets and can be revaccinated with a live M. gallisepticum vaccine such as FMG at a later date with no deleterious effects on egg production or egg or eggshell quality parameters.

High sensitivity test of the Pauli Exclusion Principle for electrons with X-ray spectroscopy (VIP2)

NASA Astrophysics Data System (ADS)

Marton, Johann; VIP2 Collaboration

2015-10-01

The Pauli Exclusion Principle (PEP) is one of the most fundamental rules in physics and it has various important consequences ranging from atomic and subatomic systems to the stability of matter and stellar objects like neutron stars. Due to many observations This rule must be valid to an extremely high degree and consequently no violations were found so far. On the other hand a simple explanation of PEP is still missing. Many experimental investigations based on different assumptions were performed to search for a tiny PEP violation in various systems. The experiment VIP2 at the Gran Sasso underground laboratory (LNGS of INFN) is designed to test the PEP for electrons with high sensitivity by searching for forbidden X-ray transitions in copper atoms. This experiment aims to improve the PEP violation limit obtained with our preceding experiment VIP by orders of magnitude. The experimental method, comparison of the VIP result with different PEP searches and the present status of the VIP2 experiment will be presented. We acknowledge the support from the: HadronPhysics FP6 (506078), HadronPhysics2 FP7 (227431), HadronPhysics3 (283286) projects, EU COST Action 1006 (Fundamental Problems in Quantum Physics) and the Austrian Science Fund (FWF).

A tunable electrochromic fabry-perot filter for adaptive optics applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blaich, Jonathan David; Kammler, Daniel R.; Ambrosini, Andrea

2006-10-01

The potential for electrochromic (EC) materials to be incorporated into a Fabry-Perot (FP) filter to allow modest amounts of tuning was evaluated by both experimental methods and modeling. A combination of chemical vapor deposition (CVD), physical vapor deposition (PVD), and electrochemical methods was used to produce an ECFP film stack consisting of an EC WO{sub 3}/Ta{sub 2}O{sub 5}/NiO{sub x}H{sub y} film stack (with indium-tin-oxide electrodes) sandwiched between two Si{sub 3}N{sub 4}/SiO{sub 2} dielectric reflector stacks. A process to produce a NiO{sub x}H{sub y} charge storage layer that freed the EC stack from dependence on atmospheric humidity and allowed construction ofmore » this complex EC-FP stack was developed. The refractive index (n) and extinction coefficient (k) for each layer in the EC-FP film stack was measured between 300 and 1700 nm. A prototype EC-FP filter was produced that had a transmission at 500 nm of 36%, and a FWHM of 10 nm. A general modeling approach that takes into account the desired pass band location, pass band width, required transmission and EC optical constants in order to estimate the maximum tuning from an EC-FP filter was developed. Modeling shows that minor thickness changes in the prototype stack developed in this project should yield a filter with a transmission at 600 nm of 33% and a FWHM of 9.6 nm, which could be tuned to 598 nm with a FWHM of 12.1 nm and a transmission of 16%. Additional modeling shows that if the EC WO{sub 3} absorption centers were optimized, then a shift from 600 nm to 598 nm could be made with a FWHM of 11.3 nm and a transmission of 20%. If (at 600 nm) the FWHM is decreased to 1 nm and transmission maintained at a reasonable level (e.g. 30%), only fractions of a nm of tuning would be possible with the film stack considered in this study. These tradeoffs may improve at other wavelengths or with EC materials different than those considered here. Finally, based on our limited investigation and material set, the severe absorption associated with the refractive index change suggests that incorporating EC materials into phase correcting spatial light modulators (SLMS) would allow for only negligible phase correction before transmission losses became too severe. However, we would like to emphasize that other EC materials may allow sufficient phase correction with limited absorption, which could make this approach attractive.« less

Earth Observation oriented teaching materials development based on OGC Web services and Bashyt generated reports

NASA Astrophysics Data System (ADS)

Stefanut, T.; Gorgan, D.; Giuliani, G.; Cau, P.

2012-04-01

Creating e-Learning materials in the Earth Observation domain is a difficult task especially for non-technical specialists who have to deal with distributed repositories, large amounts of information and intensive processing requirements. Furthermore, due to the lack of specialized applications for developing teaching resources, technical knowledge is required also for defining data presentation structures or in the development and customization of user interaction techniques for better teaching results. As a response to these issues during the GiSHEO FP7 project [1] and later in the EnviroGRIDS FP7 [2] project, we have developed the eGLE e-Learning Platform [3], a tool based application that provides dedicated functionalities to the Earth Observation specialists for developing teaching materials. The proposed architecture is built around a client-server design that provides the core functionalities (e.g. user management, tools integration, teaching materials settings, etc.) and has been extended with a distributed component implemented through the tools that are integrated into the platform, as described further. Our approach in dealing with multiple transfer protocol types, heterogeneous data formats or various user interaction techniques involve the development and integration of very specialized elements (tools) that can be customized by the trainers in a visual manner through simple user interfaces. In our concept each tool is dedicated to a specific data type, implementing optimized mechanisms for searching, retrieving, visualizing and interacting with it. At the same time, in each learning resource can be integrated any number of tools, through drag-and-drop interaction, allowing the teacher to retrieve pieces of data of various types (e.g. images, charts, tables, text, videos etc.) from different sources (e.g. OGC web services, charts created through Bashyt application, etc.) through different protocols (ex. WMS, BASHYT API, FTP, HTTP etc.) and to display them all together in a unitary manner using the same visual structure [4]. Addressing the High Power Computation requirements that are met while processing environmental data, our platform can be easily extended through tools that connect to GRID infrastructures, WCS web services, Bashyt API (for creating specialized hydrological reports) or any other specialized services (ex. graphics cluster visualization) that can be reached over the Internet. At run time, on the trainee's computer each tool is launched in an asynchronous running mode and connects to the data source that has been established by the teacher, retrieving and displaying the information to the user. The data transfer is accomplished directly between the trainee's computer and the corresponding services (e.g. OGC, Bashyt API, etc.) without passing through the core server platform. In this manner, the eGLE application can provide better and more responsive connections to a large number of users.

SUNLAB - The Project of a Polish Underground Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kisiel, J.; Dorda, J.; Konefall, A.

2010-11-24

The project of the first Polish underground laboratory SUNLAB, in the Polkowice-Sieroszowice copper mine, belonging to the KGHM Polska Miedz S.A. holding, is presented. Two stages of the project are foreseen: SUNLAB1 (a small laboratory in the salt layer exhibiting extremely low level of natural radioactivity) and SUNLAB2 (a big laboratory in the anhydrite layer, able to host the next generation liquid argon detector - GLACIER, which is considered within the LAGUNA FP7 project). The results of the natural radioactivity background measurements performed in the Polkowice-Sieroszowice salt cavern are also briefly summarized.

SUNLAB-The Project of a Polish Underground Laboratory

NASA Astrophysics Data System (ADS)

Kisiel, J.; Budzanowski, M.; Chorowski, M.; Cygan, S.; Dorda, J.; Hanzel, S.; Harańczyk, M.; Horoszczak, L.; Januszewska, K.; Jaroń, L.; Konefalł, A.; Kozak, K.; Lankof, L.; Mania, S.; Markiewicz, A.; Markowski, P.; Mazur, J.; Mertuszka, P.; Mietelski, J. W.; Poliński, J.; Puchalska, M.; Pytel, W.; Raczyński, M.; Sadecki, Z.; Sadowski, A.; Ślizowski, J.; Sulej, R.; Szarska, M.; Szeglowski, T.; Tomankiewicz, E.; Urbańczyk, K.; Zalewska, A.

2010-11-01

The project of the first Polish underground laboratory SUNLAB, in the Polkowice-Sieroszowice copper mine, belonging to the KGHM Polska Miedź S.A. holding, is presented. Two stages of the project are foreseen: SUNLAB1 (a small laboratory in the salt layer exhibiting extremely low level of natural radioactivity) and SUNLAB2 (a big laboratory in the anhydrite layer, able to host the next generation liquid argon detector-GLACIER, which is considered within the LAGUNA FP7 project). The results of the natural radioactivity background measurements performed in the Polkowice-Sieroszowice salt cavern are also briefly summarized.

Improving risk-stratification of Diabetes complications using temporal data mining.

PubMed

Sacchi, Lucia; Dagliati, Arianna; Segagni, Daniele; Leporati, Paola; Chiovato, Luca; Bellazzi, Riccardo

2015-01-01

To understand which factor trigger worsened disease control is a crucial step in Type 2 Diabetes (T2D) patient management. The MOSAIC project, funded by the European Commission under the FP7 program, has been designed to integrate heterogeneous data sources and provide decision support in chronic T2D management through patients' continuous stratification. In this work we show how temporal data mining can be fruitfully exploited to improve risk stratification. In particular, we exploit administrative data on drug purchases to divide patients in meaningful groups. The detection of drug consumption patterns allows stratifying the population on the basis of subjects' purchasing attitude. Merging these findings with clinical values indicates the relevance of the applied methods while showing significant differences in the identified groups. This extensive approach emphasized the exploitation of administrative data to identify patterns able to explain clinical conditions.

Using AQUACROP to model the impacts of future climates on crop production and possible adaptation strategies in Sardinia and Tunisia

NASA Astrophysics Data System (ADS)

Bird, Neil; Benabdallah, Sihem; Gouda, Nadine; Hummel, Franz; La Jeunesse, Isabelle; Meyer, Swen; Soddu, Antonino; Woess-Gallasch, Susanne

2014-05-01

A work package in the FP-7 funded CLIMB Project - Climate Induced Changes on the Hydrology of Mediterranean Basins Reducing Uncertainty and Quantifying Risk through an Integrated Monitoring and Modeling System had the goal of assessing socioeconomic vulnerability in two super-sites in future climates (2040-2070). The work package had deliverables to describe of agricultural adaptation measures appropriate to each site under future water availability scenarios and assess the risk of income losses due to water shortages in agriculture. The FAO model AQUACROP was used to estimate losses of agricultural productivity and indicate possible adaptation strategies. The presentation will focus on two interesting crops which show extreme vulnerability to expected changes in climate; irrigated lettuce in Sardinia and irrigated tomatoes in Tunisia. Modelling methodology, results and possible adaptation strategies will be presented.

Three-Quarters of Persons in the US Population Reporting a Clinical Diagnosis of Fibromyalgia Do Not Satisfy Fibromyalgia Criteria: The 2012 National Health Interview Survey.

PubMed

Walitt, Brian; Katz, Robert S; Bergman, Martin J; Wolfe, Frederick

2016-01-01

Although fibromyalgia criteria have been in effect for decades, little is known about how the fibromyalgia diagnosis is applied and understood by clinicians and patients. We used the National Health Interview Survey (NHIS) to determine the prevalence of self-reported clinician diagnosed fibromyalgia and then compared demographics, symptoms, disability and medical utilization measures of persons with a clinical diagnosis of fibromyalgia that did not meet diagnostic criteria (false-positive or prior [F/P] fibromyalgia) to persons with and without criteria-positive fibromyalgia. The National Health Interview Survey (NHIS) collected information about both clinical diagnosis and symptoms of fibromyalgia that was appropriately weighted to represent 225,726,257 US adults. Surrogate NHIS diagnostic criteria for fibromyalgia were developed based on the level of polysymptomatic distress (PSD) as characterized in the 2011 modified American College of Rheumatology criteria (ACR) for fibromyalgia. Persons with F/P fibromyalgia were compared with persons who do not have fibromyalgia and those meeting surrogate NHIS fibromyalgia criteria. Of the 1.78% of persons reporting a clinical diagnosis, 73.5% did not meet NHIS fibromyalgia criteria. The prevalence of F/P fibromyalgia is 1.3%. F/P fibromyalgia is associated with a mild degree of polysymptomatic distress (NHIS PSD score 6.2) and characterized by frequent but not widespread pain and insomnia. Measures of work disability and medical utilization in F/P fibromyalgia were equal to that seen with NHIS criteria positive fibromyalgia and were 6-7x greater in F/P fibromyalgia than in non-fibromyalgia persons. F/P fibromyalgia was best predicted by being female (Odds Ratio [OR] 8.81), married (OR 3.27), and white (OR 1.96). In contrast, being a white, married woman was only modestly predictive of NHIS (criteria positive) fibromyalgia (OR 2.1). The majority of clinically diagnosed fibromyalgia cases in the US do not reach levels of severity necessary and sufficient for diagnosis. The clinical diagnosis of fibromyalgia is disproportionally dependent on demographic and social factors rather than the symptoms themselves. Diagnostic criteria for fibromyalgia appear to be used as a vague guide by clinicians and patients, and allow for substantial diagnostic expansion of fibromyalgia.

Three-Quarters of Persons in the US Population Reporting a Clinical Diagnosis of Fibromyalgia Do Not Satisfy Fibromyalgia Criteria: The 2012 National Health Interview Survey

PubMed Central

Walitt, Brian; Katz, Robert S.; Bergman, Martin J.; Wolfe, Frederick

2016-01-01

Objectives Although fibromyalgia criteria have been in effect for decades, little is known about how the fibromyalgia diagnosis is applied and understood by clinicians and patients. We used the National Health Interview Survey (NHIS) to determine the prevalence of self-reported clinician diagnosed fibromyalgia and then compared demographics, symptoms, disability and medical utilization measures of persons with a clinical diagnosis of fibromyalgia that did not meet diagnostic criteria (false-positive or prior [F/P] fibromyalgia) to persons with and without criteria-positive fibromyalgia. Methods The National Health Interview Survey (NHIS) collected information about both clinical diagnosis and symptoms of fibromyalgia that was appropriately weighted to represent 225,726,257 US adults. Surrogate NHIS diagnostic criteria for fibromyalgia were developed based on the level of polysymptomatic distress (PSD) as characterized in the 2011 modified American College of Rheumatology criteria (ACR) for fibromyalgia. Persons with F/P fibromyalgia were compared with persons who do not have fibromyalgia and those meeting surrogate NHIS fibromyalgia criteria. Results Of the 1.78% of persons reporting a clinical diagnosis, 73.5% did not meet NHIS fibromyalgia criteria. The prevalence of F/P fibromyalgia is 1.3%. F/P fibromyalgia is associated with a mild degree of polysymptomatic distress (NHIS PSD score 6.2) and characterized by frequent but not widespread pain and insomnia. Measures of work disability and medical utilization in F/P fibromyalgia were equal to that seen with NHIS criteria positive fibromyalgia and were 6-7x greater in F/P fibromyalgia than in non-fibromyalgia persons. F/P fibromyalgia was best predicted by being female (Odds Ratio [OR] 8.81), married (OR 3.27), and white (OR 1.96). In contrast, being a white, married woman was only modestly predictive of NHIS (criteria positive) fibromyalgia (OR 2.1). Conclusions The majority of clinically diagnosed fibromyalgia cases in the US do not reach levels of severity necessary and sufficient for diagnosis. The clinical diagnosis of fibromyalgia is disproportionally dependent on demographic and social factors rather than the symptoms themselves. Diagnostic criteria for fibromyalgia appear to be used as a vague guide by clinicians and patients, and allow for substantial diagnostic expansion of fibromyalgia. PMID:27281286

Balancing the Needs between Training for Future Scientists and Broader Societal Needs--SECURE Project Research on Mathematics, Science and Technology Curricula and Their Implementation

ERIC Educational Resources Information Center

Sokolowska, D.; de Meyere, J.; Folmer, E.; Rovsek, B.; Peeters, W.

2014-01-01

SECURE is a collaborative project under FP7 to provide research results of current mathematics, science and technology (MST) curricula across Europe. The research focuses on the MST curricula offered to 5, 8, 11 and 13 year old learners in ten European countries. The consortium invited 60 schools from each partner country to participate in the…

Environmental Impact of Megacities - Results from CityZen

NASA Astrophysics Data System (ADS)

Gauss, M.

2012-04-01

Megacities have increasingly important impacts on air quality and climate change on different spatial scales, owing to their high population densities and concentrated emission sources. The EU FP7 project CityZen (Megacity - Zoom for the Environment) ended in 2011 and was, together with its sister project MEGAPOLI, part of a major research effort within FP7 on megacities in Europe and worldwide. The project mainly focused on air pollution trends in large cities and emission hotspots, climate-chemistry couplings, future projections, and emission mitigation options. Both observational and modeling tools have been extensively used. This paper reviews some of the main results from CityZen regarding present air pollution in and around megacities, future scenarios and mitigation options to reduce air pollution and/or climate change, and the main policy messages from the project. The different observed trends over European and Asian hotspots during the last 10 to 15 years are shown. Results of source attribution of pollutants, which have been measured and calculated in and around the different selected hot spots in CityZen will be discussed. Another important question to be addressed is the extent to which climate change will affect air quality and the effectiveness of air quality legislation. Although projected emission reductions are a major determinate influencing the predictions of future air pollution, model results suggest that climate change has to be taken into account when devising future air quality legislation. This paper will also summarize some important policy messages in terms of ozone, particles and the observational needs that have been put forward as conclusions from the project.

Community Dialogue to Shift Social Norms and Enable Family Planning: An Evaluation of the Family Planning Results Initiative in Kenya

PubMed Central

Creanga, Andreea A.; Galavotti, Christine; Wamalwa, Emmanuel

2016-01-01

Introduction Use of family planning (FP) is powerfully shaped by social and gender norms, including the perceived acceptability of FP and gender roles that limit women’s autonomy and restrict communication and decision-making between men and women. This study evaluated an intervention that catalyzed ongoing community dialogues about gender and FP in Siaya county, Nyanza Province, Kenya. Specifically, we explored the changes in perceived acceptability of FP, gender norms and use of FP. Methods We used a mixed-method approach. Information on married men and women’s socio-demographic characteristics, pregnancy intentions, gender-related beliefs, FP knowledge, attitudes, and use were collected during county-representative, cross-sectional household surveys at baseline (2009; n11 = 650 women; n12 = 305 men) and endline (2012; n21 = 617 women; n22 = 317 men); exposure to the intervention was measured at endline. We assessed changes in FP use at endline vs. baseline, and fitted multivariate logistic regression models for FP use to examine its association with intervention exposure and explore other predictors of use at endline. In-depth, qualitative interviews with 10 couples at endline further explored enablers and barriers to FP use. Results At baseline, 34.0% of women and 27.9% of men used a modern FP method compared to 51.2% and 52.2%, respectively, at endline (p<0.05). Exposure to FP dialogues was associated with 1.78 (95% CI: 1.20–2.63) times higher odds of using a modern FP method at endline for women, but this association was not significant for men. Women’s use of modern FP was significantly associated with higher spousal communication, control over own cash earnings, and FP self-efficacy. Men who reported high approval of FP were significantly more likely to use modern FP if reporting high approval of FP and more equitable gender beliefs. FP dialogues addressed persistent myths and misconceptions, normalized FP discussions, and increased its acceptability. Public examples of couples making joint FP decisions legitimized communication and decision-making with spouses about FP especially for men; women described partner support as key enabler of FP use. Conclusions Our evaluation demonstrates that an intervention that catalyzes open dialogue about gender and FP can shift social norms, enable more equitable couple communication and decision-making and, ultimately, increase use of FP. PMID:27124177

Environmental change and water-related, vector borne diseases in eastern Africa: the HEALTHY FUTURES project

NASA Astrophysics Data System (ADS)

Taylor, David; Kienberger, Stefan; Tompkins, Adrian

2015-04-01

Pathogens that spend time outside the human body, and any organisms involved in their transmission, have particular ecological requirements; as environment, including climate, conditions change, then the transmission characteristics of associated pathogens - and the diseases caused - are also likely to vary. Relationships between environment and health in many parts of the world remain poorly studied and are often overlooked, however. This is particularly the case in developing countries, because of budgetary and available expertise constraints. Moreover the relationship is often confounded by other factors. These other factors contribute to human vulnerability, and thus to the overall disease risk due to environmental change. This presentation will highlight the importance of environmental, including climate, change information to a better understanding of the risks to health of projected future environmental changes, and to the more efficient and effective use of scarce health resources in the developing world. The paper will focus on eastern Africa, and in particular the health effects of future projected environmental change impacts on water-related, vector borne diseases in the East African Community region. Moreover the paper will highlight how the EU FP7-funded project HEALTHY FUTURES is, through a broadly-based, integrative approach that distinguishes environmental change-induced health hazard from health risk aims to support the health decisions making process, thereby attempting to help mitigate negative health impacts.

78 FR 54873 - Notice of Intent To Prepare an Environmental Impact Statement for Multiple Projects in Support of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-06

... standards, life safety, sustainability, and energy efficiency, and Anti-Terrorism and Force Protection (AT.../FP and life safety standards, improve space utilization, and meet sustainability goals. The... public services for DC residents, to include public housing, education, or public recreation services...

Hatfield Marine Science Center Dynamic Revetment Project DSL Permit # 45455-FP. Monitoring Report. February, 2014.

EPA Science Inventory

Stabilization of the Yaquina Bay shoreline along the northeastern edge of the Hatfield Marine Science Center (HMSC) campus became necessary to halt erosion that threatened both HMSC critical infrastructure (seawater storage tank) and public access to the HMSC Nature Trail. A Dyn...

Hatfield Marine Science Center Dynamic Revetment Project DSL Permit # 45455-FP. Monitoring Report. February, 2016

EPA Science Inventory

Stabilization of the Yaquina Bay shoreline along the northeastern edge of the Hatfield Marine Science Center (HMSC) campus became necessary to halt erosion that threatened both HMSC critical infrastructure (seawater storage tank) and public access to the HMSC Nature Trail. A Dyn...

Hatfield Marine Science Center Dynamic Revetment Project DSL permit # 45455-FP, Monitoring Report February, 2015

EPA Science Inventory

Stabilization of the Yaquina Bay shoreline along the northeastern edge of the Hatfield Marine Science Center (HMSC) campus became necessary to halt erosion that threatened both HMSC critical infrastructure (seawater storage tank) and public access to the HMSC Nature Trail. A Dyn...

Anisotropic transport of microalgae Chlorella vulgaris in microfluidic channel

NASA Astrophysics Data System (ADS)

Izzati Ishak, Nur; Muniandy, S. V.; Periasamy, Vengadesh; Ng, Fong-Lee; Phang, Siew-Moi

2017-08-01

Not Available Project supported by the Science Fund from the Ministry of Higher Education of Malaysia under the Fundamental Research Grant Scheme (Grant No. FRGS: FP057-2014A) and the Fund from the University of Malaya Research Grant (Grant No. UMRG: RP020A-14AFR).

Investigating Near Space Interaction Regions: Developing a Remote Observatory

NASA Astrophysics Data System (ADS)

Gallant, M.; Mierkiewicz, E. J.; Oliversen, R. J.; Jaehnig, K.; Percival, J.; Harlander, J.; Englert, C. R.; Kallio, R.; Roesler, F. L.; Nossal, S. M.; Gardner, D.; Rosborough, S.

2016-12-01

The Investigating Near Space Interaction Regions (INSpIRe) effort will (1) establish an adaptable research station capable of contributing to terrestrial and planetary aeronomy; (2) integrate two state-of-the-art second generation Fabry-Perot (FP) and Spatial Heteorodyne Spectrometers (SHS) into a remotely operable configuration; (3) deploy this instrumentation to a clear-air site, establishing a stable, well-calibrated observatory; (4) embark on a series of observations designed to contribute to three major areas of geocoronal research: geocoronal physics, structure/coupling, and variability. This poster describes the development of the INSpIRe remote observatory. Based at Embry-Riddle Aeronautical University (ERAU), initiative INSpIRe provides a platform to encourage the next generation of researchers to apply knowledge gained in the classroom to real-world science and engineering. Students at ERAU contribute to the INSpIRe effort's hardware and software needs. Mechanical/optical systems are in design to bring light to any of four instruments. Control software is in development to allow remote users to control everything from dome and optical system operations to calibration and data collection. In April 2016, we also installed and tested our first science instrument in the INSpIRe trailer, the Redline DASH Demonstration Instrument (REDDI). REDDI uses Doppler Asymmetric Spatial Heterodyne (DASH) spectroscopy, and its deployment as part of INSpIRe is a collaborative research effort between the Naval Research Lab, St Cloud State University, and ERAU. Similar to a stepped Michelson device, REDDI measures oxygen (630.0 nm) winds from the thermosphere. REDDI is currently mounted in a temporary location under INSpIRe's main siderostat until its entrance optical system can be modified. First light tests produced good signal-to-noise fringes in ten minute integrations, indicating that we will soon be able to measure thermospheric winds from our Daytona Beach testing site. Future work will involve installation and software integration of FP and SHS systems and the Embry-Riddle Instrument Control System. The INSpIRe project is funded through NSF-CAREER award AGS135231 and the NASA Planetary Solar System Observations Program. The REDDI instrument was supported by the Chief of Naval Research.

Reproductive health service utilization and associated factors among adolescents (15–19 years old) in Gondar town, Northwest Ethiopia

PubMed Central

2013-01-01

Background The utilization of reproductive health services is an important component in preventing adolescents from different sexual and reproductive health problems. It plays a vital role in safeguarding youth in Sub-Saharan African countries including Ethiopia, which accounts for a high proportion of the region’s new HIV infections as well as maternal and infant mortality ratios. Due to this, assessing adolescent reproductive health service utilization and associated factors has its own contribution in achieving the national Millennium Development Goals (MDG), especially goals 4 to 6. Methods A community based cross-sectional study was conducted from April 5–19, 2012, in 4 randomly selected administrative areas of Gondar town. A total of 1290 adolescents aged 15–19 were interviewed using a pre-tested and structured questionnaire. Data were entered in to the EPI INFO version 3.5.3 statistical software and analyzed using an adapted SPSS version 20 software package. Logistic regression was done to identify possible factors associated with family planning (FP), and voluntary counseling and testing (VCT) service utilization. Results Out of the total participants, 79.5% and 72.2% utilized FP and VCT services, respectively. In addition, among sexually experienced adolescents, 68.1% and 88.4% utilized contraceptive methods and VCT service during their first sexual encounter, respectively. Educational status, discussion with family/relatives, peer groups, sexual partners and teachers were significantly associated with FP service utilization. Also, adolescents who had a romantic sexual relationship, and those whose last sexual relationship was long-term, were about 6.5 times (Adjusted Odds Ratio [AOR] = 6.5, 95% CI: 1.23, 34.59), and about 3 times (AOR = 3, 95% CI: 1.02, 8.24) more likely to utilize FP services than adolescents who had no romantic relationship or long-term sexual relationship, respectively. In addition, the variables significantly associated with VCT service utilization were: participants who had secondary education and above, schooling attendance, co- residence with both parents, parental communication, discussion of services with peer groups, health workers, and perception of a risk of HIV/AIDS. Conclusions The majority of the adolescents were utilizing FP and VCT service in Northwest Ethiopia. But among the sexually experienced adolescents, utilization of FP at first sexual intercourse and VCT service were found to be low. Educational status, schooling attendance, discussion of services, type of sexual relationship and perception of risk were important factors affecting the utilization of FP and VCT services. Building life skill, facilitating parent to child communication, establishing and strengthening of youth centers and school reproductive health clubs are important steps to improve adolescents’ reproductive health (RH) service utilization. PMID:23915299

Enhancing the Awareness of the Interaction of the Space Weather and Public: Some Case Studies in Turkey

NASA Astrophysics Data System (ADS)

Tulunay, Y.; Tulunay, E.; Kocabas, Z.; Altuntas, E.; Yapici, T.; Senalp, E. T.; Hippler, R.

2009-04-01

Space Weather has important effects on many systems and peripherals that human interacts with. However, most of the people are not aware of those interactions. During the FP6 SWEETS, COST 724 and the ‘I love my Sun' activities it was aimed to create basis to bring together academicians from universities, experts from industry, scientific institutes, and the public, especially the school children of age 7-11, in order to enhance the awareness of space weather effects and to discuss appropriate countermeasures by different education and promotion methods including non-technical ones. This work mentions the activities performed in Turkey within the framework. Since 1990, a small group at METU has been developing data driven models in order to forecast some critical system parameters related with the near-Earth space processes. With the background on the subject the group feels responsible to organise activities in Turkey to inform public on enhancing the awareness of space weather effects. In order to inform and educate public on their interaction with the Space Weather, distinct social activities which take quick and strong attention were organised. Those include art shows and workshops, quizes, movies and entertainments, special programs for school children of age 7-11 under the ‘I love my Sun' activities, press releases, audio-visual media including webpages [Tulunay, 2007]. The impact of the activities can be evaluated considering the before and after activity record materials of the participants. For instance, under the ‘I love my Sun' activities, the school children drew pictures related with Sun before and after the informative programs. The performance of reaching the school children on the subject is very promising. Sub-activities conducted under the action are: 1. Space Weather Dance Show "Sonnensturm" 2. Web Quiz all over Europe: In Türkiye 3. Space Weather / Sun / Heliospheric Public Science Festivals in 27 Countries: In Türkiye 4. Space Weather on Tour-Mobile Bus 5. Rocket / balloon launch participation for European web quiz winner and journalists 6. Space Weather / Solar / Aurora / Rocket / Balloon movie production for TV 7. Space Weather / Sun /Heliospheric public science festival & public fair in Schwerin castle (main SWEETS festival during ESW 2007) 8. Space Weather telescope video link with Australian (Antarctic Mawson station) and Japanese locations for Schwerin castle festival (no. 7 deliverable) 9. Space Weather planetarium show in Poland, Finland, France and Portugal (4 new languages) 10. Updated Space Weather / Solar CD-Rom / DVD in 7 new languages, poster / flyer 11. Cosmic ray spark chambers 12. Space Weather storm forecast map 13. Mirror system for solar movie 14. FP6 SWEETS / IHY / COST 724 Case Sub-project: "I LOVE MY SUN" (An outreach Activity in Turkey: The Space Weather and the Sun as conceived by the School Children of age 7-11) 15. Press Releases 16. FP6 SWEETS Related Art 17. Turkish Translations in IHY and COST webpages 18. Impact of the SWEETS References Tulunay Y. (2007), FP6 SWEETS (SSA) Activity Report of the Participant No. 16: the METU in Ankara, Türkiye, 31 December 2007, www.ae.metu.edu.tr/~cost.

Approaching a network connectivity-driven classification of the psychosis continuum: a selective review and suggestions for future research.

PubMed

Schmidt, André; Diwadkar, Vaibhav A; Smieskova, Renata; Harrisberger, Fabienne; Lang, Undine E; McGuire, Philip; Fusar-Poli, Paolo; Borgwardt, Stefan

2014-01-01

Brain changes in schizophrenia evolve along a dynamic trajectory, emerging before disease onset and proceeding with ongoing illness. Recent investigations have focused attention on functional brain interactions, with experimental imaging studies supporting the disconnection hypothesis of schizophrenia. These studies have revealed a broad spectrum of abnormalities in brain connectivity in patients, particularly for connections integrating the frontal cortex. A critical point is that brain connectivity abnormalities, including altered resting state connectivity within the fronto-parietal (FP) network, are already observed in non-help-seeking individuals with psychotic-like experiences. If we consider psychosis as a continuum, with individuals with psychotic-like experiences at the lower and psychotic patients at the upper ends, individuals with psychotic-like experiences represent a key population for investigating the validity of putative biomarkers underlying the onset of psychosis. This paper selectively addresses the role played by FP connectivity in the psychosis continuum, which includes patients with chronic psychosis, early psychosis, clinical high risk, genetic high risk, as well as the general population with psychotic experiences. We first discuss structural connectivity changes among the FP pathway in each domain in the psychosis continuum. This may provide a basis for us to gain an understanding of the subsequent changes in functional FP connectivity. We further indicate that abnormal FP connectivity may arise from glutamatergic disturbances of this pathway, in particular from abnormal NMDA receptor-mediated plasticity. In the second part of this paper we propose some concepts for further research on the use of network connectivity in the classification of the psychosis continuum. These concepts are consistent with recent efforts to enhance the role of data in driving the diagnosis of psychiatric spectrum diseases.

Approaching a network connectivity-driven classification of the psychosis continuum: a selective review and suggestions for future research

PubMed Central

Schmidt, André; Diwadkar, Vaibhav A.; Smieskova, Renata; Harrisberger, Fabienne; Lang, Undine E.; McGuire, Philip; Fusar-Poli, Paolo; Borgwardt, Stefan

2015-01-01

Brain changes in schizophrenia evolve along a dynamic trajectory, emerging before disease onset and proceeding with ongoing illness. Recent investigations have focused attention on functional brain interactions, with experimental imaging studies supporting the disconnection hypothesis of schizophrenia. These studies have revealed a broad spectrum of abnormalities in brain connectivity in patients, particularly for connections integrating the frontal cortex. A critical point is that brain connectivity abnormalities, including altered resting state connectivity within the fronto-parietal (FP) network, are already observed in non-help-seeking individuals with psychotic-like experiences. If we consider psychosis as a continuum, with individuals with psychotic-like experiences at the lower and psychotic patients at the upper ends, individuals with psychotic-like experiences represent a key population for investigating the validity of putative biomarkers underlying the onset of psychosis. This paper selectively addresses the role played by FP connectivity in the psychosis continuum, which includes patients with chronic psychosis, early psychosis, clinical high risk, genetic high risk, as well as the general population with psychotic experiences. We first discuss structural connectivity changes among the FP pathway in each domain in the psychosis continuum. This may provide a basis for us to gain an understanding of the subsequent changes in functional FP connectivity. We further indicate that abnormal FP connectivity may arise from glutamatergic disturbances of this pathway, in particular from abnormal NMDA receptor-mediated plasticity. In the second part of this paper we propose some concepts for further research on the use of network connectivity in the classification of the psychosis continuum. These concepts are consistent with recent efforts to enhance the role of data in driving the diagnosis of psychiatric spectrum diseases. PMID:25628553

EuCARD 2010: European coordination of accelerator research and development

NASA Astrophysics Data System (ADS)

Romaniuk, Ryszard S.

2010-09-01

Accelerators are basic tools of the experimental physics of elementary particles, nuclear physics, light sources of the fourth generation. They are also used in myriad other applications in research, industry and medicine. For example, there are intensely developed transmutation techniques for nuclear waste from nuclear power and atomic industries. The European Union invests in the development of accelerator infrastructures inside the framework programs to build the European Research Area. The aim is to build new accelerator research infrastructures, develop the existing ones, and generally make the infrastructures more available to competent users. The paper summarizes the first year of activities of the EU FP7 Project Capacities EuCARD -European Coordination of Accelerator R&D. EuCARD is a common venture of 37 European Accelerator Laboratories, Institutes, Universities and Industrial Partners involved in accelerator sciences and technologies. The project, initiated by ESGARD, is an Integrating Activity co-funded by the European Commission under Framework Program 7 - Capacities for a duration of four years, starting April 1st, 2009. Several teams from this country participate actively in this project. The contribution from Polish research teams concerns: photonic and electronic measurement - control systems, RF-gun co-design, thin-film superconducting technology, superconducting transport infrastructures, photon and particle beam measurements and control.

The 6dFGS Peculiar Velocity Field

NASA Astrophysics Data System (ADS)

Springob, Chris M.; Magoulas, C.; Colless, M.; Mould, J.; Erdogdu, P.; Jones, D. H.; Lucey, J.; Campbell, L.; Merson, A.; Jarrett, T.

2012-01-01

The 6dF Galaxy Survey (6dFGS) is an all southern sky galaxy survey, including 125,000 redshifts and a Fundamental Plane (FP) subsample of 10,000 peculiar velocities, making it the largest peculiar velocity sample to date. We have fit the FP using a maximum likelihood fit to a tri-variate Gaussian. We subsequently compute a Bayesian probability distribution for every possible peculiar velocity for each of the 10,000 galaxies, derived from the tri-variate Gaussian probability density distribution, accounting for our selection effects and measurement errors. We construct a predicted peculiar velocity field from the 2MASS redshift survey, and compare our observed 6dFGS velocity field to the predicted field. We discuss the resulting agreement between the observed and predicted fields, and the implications for measurements of the bias parameter and bulk flow.

All-optical diode structure based on asymmetrical coupling by a micro-cavity and FP cavity at two sides of photonic crystal waveguide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Bin, E-mail: liubin-d@126.com; Liu, Yun-Feng; He, Xing-Dao

2016-06-15

A high efficiency all-optical diode based on photonic crystal (PC) waveguide has been proposed and numerically investigated by finite-difference time-domain (FDTD) method. The structure is asymmetrically coupled by a micro-cavity containing nonlinear Kerr medium and a FP cavity at sides of PC waveguide. Because of interference between two cavities, Fano peak and FP peak can both appear in transmission spectra and unidirectional transmission can be achieved. The working wavelength can set between two peaks and near to the Fano peak. For forward launch with suitable light intensity, nonlinear Kerr effect of micro-cavity can been excited. It will result in redmore » shift of Fano peak and achieving forward transmission. But for backward launch, a stronger incidence light is needed to the excite Kerr effect due to the design of asymmetric structure. This design has many advantages, including high maximum transmittance, high transmittance contrast ratio, low power threshold, short response time, and ease of integration.« less

Effects of cultivar and grazing initiation date on fall-grown oat for replacement dairy heifers.

PubMed

Coblentz, W K; Brink, G E; Esser, N M; Cavadini, J S

2015-09-01

Fall-grown oat has shown promise for extending the grazing season in Wisconsin, but the optimum date for initiating grazing has not been evaluated. Our objectives for this project were (1) to assess the pasture productivity and nutritive value of 2 oat cultivars [Ogle and ForagePlus (OG and FP, respectively)] with late-September (EG) or mid-October (LG) grazing initiation dates; and (2) to evaluate growth performance by heifers grazing these oat forages compared with heifers reared in confinement (CON). A total of 160 gravid Holstein heifers (80 heifers/yr) were assigned to 10 research groups (8 heifers/group). Mean initial body weight was 509±40.5 kg in 2013 and 517±30.2 kg in 2014. Heifer groups were assigned to specific pastures arranged as a 2×2 factorial of oat cultivars and grazing initiation dates. Grazing heifer groups were allowed to strip-graze oat pastures for 6 h daily before returning to the barn, where they were offered a forage-based basal total mixed ration. Main effects of oat cultivar and sampling date interacted for forage characteristics in 2013, but not in 2014. During 2013, oat forage mass increased until early November before declining in response to freezing weather conditions, thereby exhibiting linear and quadratic effects of sampling date, regardless of oat cultivar. Similar trends over time were observed in 2014. For 2013, the maximum forage mass was 5,329 and 5,046 kg/ha for FP and OG, respectively, whereas the mean maximum forage mass for 2014 was 4,806 kg/ha. ForagePlus did not reach the boot stage of growth during either year of the trial; OG matured more rapidly, reaching the late-heading stage during 2013, but exhibited only minor maturity differences from FP in 2014. For 2013, average daily gain for CON did not differ from grazing heifer groups (overall mean=0.63 kg/d); however, average daily gain from FP was greater than OG (0.68 vs. 0.57 kg/d), and greater from EG compared with LG (0.82 vs. 0.43 kg/d). For 2013, advantages in average daily gain for heifers grazing FP pastures were likely related to the greater energy density of FP oat throughout the fall that reached a maximum of 68.8% total digestible nutrients on November 27 compared with only 63.7% for OG on October 10. During 2014, average daily gain from CON exceeded all grazing heifer groups (0.81 vs. 0.57 kg/d), and average daily gain from EG again exceeded LG (0.70 vs. 0.44 kg/d). These results suggest that delaying grazing until mid-October will consistently suppress heifer growth performance, particularly if rapidly maturing cultivars are used. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Preparing for joint operation of numerical modelling and observational data in IMPEx

NASA Astrophysics Data System (ADS)

Al-Ubaidi, Tarek; Khodachenko, Maxim; Kallio, Esa; Génot, Vincent; Modolo, Ronan; Hess, Sébastien; Schmidt, Walter; Topf, Florian; Alexeev, Igor; Gangloff, Michel; Budnik, Elena; Bouchemit, Myriam; Renard, Benjamin; Bourrel, Natacha; Penou, Emmanuel; André, Nicolas; Belenkaya, Elena

2013-04-01

The FP7-SPACE project IMPEx (http://impex-fp7.oeaw.ac.at) was established as a result of scientific collaboration between research teams from Austria, Finland, France, and Russia, working on the integration of a set of interactive data mining, analysis and modeling tools in the field of space plasma and planetary physics. The primary goal of the project is, to bridge the gap between spacecraft measurements and modern computational models of the planetary near-by space environments, enabling their joint operation for better understanding of related physical phenomena. The major challenge of IMPEx development consists in the need to connect different types of data sources, in particular numerical simulation results and observational data. To do so, every IMPEx tool must be able to handle both kinds of data in a consistent way. Thus, a considerable part of effort is dedicated to the development of standardized (web service-) interfaces and protocols for communication between the components, as well as a common approach to share user credentials. One of the systems' cornerstones is the specification of a standard for describing and storing the different data products involved that is able to include simulation outputs as well as observational data within a common standard, i.e. Data Model (DM). The IMPEx DM is an extension of the widely used SPASE DM and constitutes the first attempt in the field of space plasma physics worldwide, to create a unified data model that is able to store simulation outputs as well as observational data products in a shared data structure. To meet the requirement of extendibility, i.e. to have a possibility to include new computational models as well as analysis and visualization tools, the IMPEx DM as well as communication protocols have been designed to be as compact as possible and yet general and powerful enough to integrate a wide range of data sets and to allow for simple procedures when attaching new components to the system. A draft version of the IMPEx DM that is being developed as this abstract is written, was presented on several international scientific conferences and recognized by professionals in the field as an important contribution and a sound starting point for the development of a unified approach to work with experimental and computationally modelled scientific data.

Mobilising Open Access to Research Data: Recommendations from the RECODE project

NASA Astrophysics Data System (ADS)

Finn, Rachel; Sveinsdottir, Thordis

2015-04-01

This paper will introduce the findings and policy recommendations from the FP7 project RECODE (Policy RECommendations for Open Access to Research Data in Europe) which aims to leverage existing networks, communities and projects to address challenges within the open access and data dissemination and preservation sector. We will introduce the key recommendations, which provide solutions relevant to opening access to PSI. The project is built on case study research of five scientific disciplines with the aim of recognizing and working with disciplinary fragmentation associated with open access to research data. The RECODE findings revealed that the mobilisation of open access to research data requires a partnership approach for developing a coherent and flexible ecosystem that is easy and transparent to embed in research practice and process. As such, the development of open access to research data needs to be: • Informed by research practices and processes in different fields • Supported by an integrated institutional and technological data infrastructure and guided by ethical and regulatory frameworks • Underpinned by infrastructure and guiding frameworks that allow for differences in disciplinary research and data management practices • Characterised by a partnership approach involving the key stakeholders, researchers, and institutions The proposed presentation will examine each of these aspects in detail and use information and good practices from the RECODE project to consider how stakeholders within the PSI movement might action each of these points. It will also highlight areas where RECODE findings and good practice recommendations have clear relevance for the PSI sector.

Characterisation of the Xenogeneic Immune Response to Microencapsulated Fetal Pig Islet-Like Cell Clusters Transplanted into Immunocompetent C57BL/6 Mice

PubMed Central

Ratnapala, Sabina; Foster, Jayne; Vaghjiani, Vijesh; Manuelpillai, Ursula; Tuch, Bernard E.

2013-01-01

Xenotransplantation of microencapsulated fetal pig islet-like cell clusters (FP ICCs) offers a potential cellular therapy for type 1 diabetes. Although microcapsules prevent direct contact of the host immune system with the xenografted tissue, poor graft survival is still an issue. This study aimed to characterise the nature of the host immune cells present on the engrafted microcapsules and effects on encapsulated FP ICCs that were transplanted into immunocompetent mice. Encapsulated FP ICCs were transplanted into the peritoneal cavity of C57BL/6 mice. Grafts retrieved at days 1, 3, 7, 14 and 21 post-transplantation were analysed for pericapsular fibrotic overgrowth (PFO), cell viability, intragraft porcine gene expression, macrophages, myofibroblasts and intraperitoneal murine cytokines. Graft function was assessed ex vivo by insulin secretion studies. Xenogeneic immune response to encapsulated FP ICCs was associated with enhanced intragraft mRNA expression of porcine antigens MIP-1α, IL-8, HMGB1 and HSP90 seen within the first two weeks post-transplantation. This was associated with the recruitment of host macrophages, infiltration of myofibroblasts and collagen deposition leading to PFO which was evident from day 7 post-transplantation. This was accompanied by a decrease in cell viability and loss of FP ICC architecture. The only pro-inflammatory cytokine detected in the murine peritoneal flushing was TNF-α with levels peaking at day 7 post transplantation. This correlated with the onset of PFO at day 7 implying activated macrophages as its source. The anti-inflammatory cytokines detected were IL-5 and IL-4 with levels peaking at days 1 and 7, respectively. Porcine C-peptide was undetectable at all time points post-transplantation. PFO was absent and murine intraperitoneal cytokines were undetectable when empty microcapsules were transplanted. In conclusion, this study demonstrated that the macrophages are direct effectors of the xenogeneic immune response to encapsulated FP ICCs leading to PFO mediated by a combination of both pro- and anti-inflammatory cytokines. PMID:23554983

Influence of Training Models at 3,900-m Altitude on the Physiological Response and Performance of a Professional Wheelchair Athlete: A Case Study.

PubMed

Sanz-Quinto, Santiago; López-Grueso, Raúl; Brizuela, Gabriel; Flatt, Andrew A; Moya-Ramón, Manuel

2018-06-20

Sanz-Quinto, S, López-Grueso, R, Brizuela, G, Flatt, AA, and Moya-Ramón, M. Influence of training models at 3,900-m altitude on the physiological response and performance of a professional wheelchair athlete: A case study. J Strength Cond Res XX(X): 000-000, 2018-This case study compared the effects of two training camps using flexible planning (FP) vs. inflexible planning (IP) at 3,860-m altitude on physiological and performance responses of an elite marathon wheelchair athlete with Charcot-Marie-Tooth disease (CMT). During IP, the athlete completed preplanned training sessions. During FP, training was adjusted based on vagally mediated heart rate variability (HRV) with specific sessions being performed when a reference HRV value was attained. The camp phases were baseline in normoxia (BN), baseline in hypoxia (BH), specific training weeks 1-4 (W1, W2, W3, W4), and Post-camp (Post). Outcome measures included the root mean square of successive R-R interval differences (rMSSD), resting heart rate (HRrest), oxygen saturation (SO2), diastolic blood pressure and systolic blood pressure, power output and a 3,000-m test. A greater impairment of normalized rMSSD (BN) was shown in IP during BH (57.30 ± 2.38% vs. 72.94 ± 11.59%, p = 0.004), W2 (63.99 ± 10.32% vs. 81.65 ± 8.87%, p = 0.005), and W4 (46.11 ± 8.61% vs. 59.35 ± 6.81%, p = 0.008). At Post, only in FP was rMSSD restored (104.47 ± 35.80%). Relative changes were shown in power output (+3 W in IP vs. +6 W in FP) and 3,000-m test (-7s in IP vs. -16s in FP). This case study demonstrated that FP resulted in less suppression and faster restoration of rMSSD and more positive changes in performance than IP in an elite wheelchair marathoner with CMT.

Population Activities Fund Agency (PAFA): the journey so far.

PubMed

1993-01-01

Mechanisms are needed funding Nigerian Federal efforts to implement the National Policy on Population for Development, which was approved by the Armed Forces Ruling Council in February, 1988. Subprojects of the Population Activities Fund Agency (PAFA) which were approves are: the integration of family planning (FP) into maternal and child health (MCH) the promotion of Fp through health education, tertiary centers for reproductive health, public enlightenment on population, population/family life education in primary schools, monitoring of National Population Project impact, and integration of population into planning and budgeting. The last obstacle to implementation of PAFA's activities is the signing into law the decree establishing PAFA as a parastatal. The passage is required for continued operations. The national Population for Development policy is unique in providing for quantitative targets, which has attracted the needed financial support of agencies such as the World Bank. As part of the National Population Policy, the National Population Program (NPP) is developing an effective strategy for securing funding and evaluation of subprojects that are designed and implemented b Collaborating Agencies (CAs), both private and public. NPP aims 1) to provide funds for qualified CAs through the Population Activities Fund (PAF) and Agency (PAFA); 2) to monitor PAFA, which manages PAf with the Department of Population Activities, and 3) to stimulate analysis of sociocultural constraints to fertility reduction and international comparisons, and to design innovative interventions through the Population Research Fund (PRF). PAFA funds implementing agencies at all government and nongovernment levels with approaches to population information and services. The goal of PAFA is to realize NPP objectives. The motto is "Towards an improved quality of life for every Nigerian." The mandate is to provide funding for the PAF and NPP, to monitor CAs, to provide assistance to CAs preparing Phase II subprojects, and to supervise and guide CAs on funding, procurement, and implementation.

Initiating or changing to a fixed-dose combination of Fluticasone propionate/Formoterol over Fluticasone propionate/Salmeterol: A real-life effectiveness and cost impact evaluation.

PubMed

Wan Yau Ming, Simon; Haughney, John; Small, Iain; Wolfe, Stephanie; Hamill, John; Gruffydd-Jones, Kevin; Daly, Cathal; Soriano, Joan B; Gardener, Elizabeth; Skinner, Derek; Stagno d'Alcontres, Martina; Price, David B

2017-08-01

Asthma has a substantial impact on quality of life and health care resources. The identification of a more cost-effective, yet equally efficacious, treatment could positively influence the economic burden of this disease. Fluticasone propionate/Formoterol (FP/FOR) may be as effective as Fluticasone Salmeterol (FP/SAL). We evaluated non-inferiority of asthma control in terms of the proportion of patients free from exacerbations, and conducted a cost impact analysis. This historical, matched cohort database study evaluated two treatment groups in the Optimum Patient Care Research Database in the UK: 1) an FP/FOR cohort of patients initiating treatment with FP/FOR or changing from FP/SAL to FP/FOR and; 2) an FP/SAL cohort comprising patients initiating, or remaining on FP/SAL pMDI combination therapy. The main outcome evaluated non-inferiority of effectiveness (defined as prevention of severe exacerbations, lower limit of the 95% confidence interval (CI) of the mean difference between groups in patient proportions with no exacerbations is -3.5% or higher) in patients treated with FP/FOR versus FP/SAL. After matching 1:3, we studied a total of 2472 patients: 618 in the FP/FOR cohort (174 patients initiated on FP/FOR and 444 patients changed to FP/FOR) and 1854 in the FP/SAL cohort (522 patients initiated FP/SAL and 1332 continued FP/SAL). The percentage of patients prescribed FP/FOR met non-inferiority as the adjusted mean difference in proportion of no severe exacerbations (95%CI) was 0.008 (-0.032, 0.047) between the two cohorts. No other significant differences were observed except acute respiratory event rates, which were lower for patients prescribed FP/FOR (rate ratio [RR] 0.82, 95% CI 0.71, 0.94). Changing to, or initiating FP/FOR combination therapy, is associated with a non-inferior proportion of patients who are severe exacerbation-free at a lower average annual cost compared with continuing or initiating treatment with FP/SAL. Copyright © 2017 Elsevier Ltd. All rights reserved.

Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study—a randomised controlled trial

PubMed Central

Frith, Peter A; Thompson, Philip J; Ratnavadivel, Rajeev; Chang, Catherina L; Bremner, Peter; Day, Peter; Frenzel, Christina; Kurstjens, Nicol

2015-01-01

Background The optimal use of various therapeutic combinations for moderate/severe chronic obstructive pulmonary disease (COPD) is unclear. The GLISTEN trial compared the efficacy of two long-acting anti-muscarinic antagonists (LAMA), when combined with an inhaled corticosteroid (ICS) and a long-acting β2 agonist (LABA). Methods This randomised, blinded, placebo-controlled trial in moderate/severe COPD patients compared once-daily glycopyrronium (GLY) 50 µg, once-daily tiotropium (TIO) 18 µg or placebo (PLA), when combined with salmeterol/fluticasone propionate (SAL/FP) 50/500 µg twice daily. The primary objective was to determine the non-inferiority of GLY+SAL/FP versus TIO+SAL/FP on trough FEV1 after 12 weeks. An important secondary objective was whether addition of GLY to SAL/FP was better than SAL/FP alone. Results 773 patients (mean FEV1 57.2% predicted) were randomised; 84.9% completed the trial. At week 12, GLY+SAL/FP demonstrated non-inferiority to TIO+SAL/FP for trough FEV1: least square mean treatment difference (LSMdiff) −7 mL (SE 17.4) with a lower limit for non-inferiority of −60 mL. There was significant increase in week 12 trough FEV1 with GLY+SAL/FP versus PLA+SAL/FP (LSMdiff 101 mL, p<0.001). At 12 weeks, GLY+SAL/FP produced significant improvement in St George's Respiratory Questionnaire total score versus PLA+SAL/FP (LSMdiff −2.154, p=0.02). GLY+SAL/FP demonstrated significant rescue medication reduction versus PLA+SAL/FP (LSMdiff −0.72 puffs/day, p<0.001). Serious adverse events were similar for GLY+SAL/FP, TIO+SAL/FP and PLA+SAL/FP with an incidence of 5.8%, 8.5% and 5.8%, respectively. Conclusions GLY+SAL/FP showed comparable improvements in lung function, health status and rescue medication to TIO+SAL/FP. Importantly, addition of GLY to SAL/FP demonstrated significant improvements in lung function, health status and rescue medication compared to SAL/FP. Trial registration number NCT01513460. PMID:25841237

Integration of miniature Fabry-Perot fiber optic sensor with FBG for the measurement of temperature and strain

NASA Astrophysics Data System (ADS)

Li, L.; Tong, X. L.; Zhou, C. M.; Wen, H. Q.; Lv, D. J.; Ling, K.; Wen, C. S.

2011-03-01

A sensor has been fabricated by the integration of a fiber Bragg gating sensor (FBGs) with a fiber Fabry-Perot (F-P) sensor fabricated by etching method. In the integrated sensor, the FBG was used to measure temperature, while the fiber Fabry-Perot interferometer sensor (FFPIs) was used for strain measurement. Wavelength decoding for FBG and peak tracking for FFPI was employed for demodulation, respectively. The result showed that the temperature and strain sensitivity for the integrated sensor is ~ 2.7 pm/ μɛand ~ 9.3 pm/°C, respectively.

Hilbert-Huang Transformation Based Analyses of FP1, FP2, and Fz Electroencephalogram Signals in Alcoholism.

PubMed

Lin, Chin-Feng; Su, Jiun-Yi; Wang, Hao-Min

2015-09-01

Chronic alcoholism may damage the central nervous system, causing imbalance in the excitation-inhibition homeostasis in the cortex, which may lead to hyper-arousal of the central nervous system, and impairments in cognitive function. In this paper, we use the Hilbert-Huang transformation (HHT) method to analyze the electroencephalogram (EEG) signals from control and alcoholic observers who watched two different pictures. We examined the intrinsic mode function (IMF) based energy distribution features of FP1, FP2, and Fz EEG signals in the time and frequency domains for alcoholics. The HHT-based characteristics of the IMFs, the instantaneous frequencies, and the time-frequency-energy distributions of the IMFs of the clinical FP1, FP2, and Fz EEG signals recorded from normal and alcoholic observers who watched two different pictures were analyzed. We observed that the number of peak amplitudes of the alcoholic subjects is larger than that of the control. In addition, the Pearson correlation coefficients of the IMFs, and the energy-IMF distributions of the clinical FP1, FP2, and Fz EEG signals recorded from normal and alcoholic observers were analyzed. The analysis results show that the energy ratios of IMF4, IMF5, and IMF7 waves of the normal observers to the refereed total energy were larger than 10 %, respectively. In addition, the energy ratios of IMF3, IMF4, and IMF5 waves of the alcoholic observers to the refereed total energy were larger than 10 %. The FP1 and FP2 waves of the normal observers, the FP1 and FP2 waves of the alcoholic observers, and the FP1 and Fz waves of the alcoholic observers demonstrated extremely high correlations. On the other hand, the FP1 waves of the normal and alcoholic observers, the FP1 wave of the normal observer and the FP2 wave of the alcoholic observer, the FP1 wave of the normal observer and the Fz wave of the alcoholic observer, the FP2 waves of the normal and alcoholic FP2 observers, and the FP2 wave of the normal observer and the Fz wave of the alcoholic observer demonstrated extremely low correlations. The IMF4 of the FP1 and FP2 signals of the normal observer, and the IMF5 of the FP1 and FP2 signals of the alcoholic observer were correlated. The IMF4 of the FP1 signal of the normal observer and that of the FP2 signal of the alcoholic observer as well as the IMF5 of the FP1 signal of the normal observer and that of the FP2 signal of the alcoholic observer exhibited extremely low correlations. In this manner, our experiment leads to a better understanding of the HHT-based IMFs features of FP1, FP2, and Fz EEG signals in alcoholism. The analysis results show that the energy ratios of the wave of an alcoholic observer to its refereed total energy for IMF4, and IMF5 in the δ band for FP1, FP2, and Fz channels were larger than those of the respective waves of the normal observer. The alcoholic EEG signals constitute more than 1 % of the total energy in the δ wave, and the reaction times were 0_4, 4_8, 8_12, and 12_16 s. For normal EEG signals, more than 1 % of the total energy is distributed in the δ wave, with a reaction time 0 to 4 s. We observed that the alcoholic subject reaction times were slower than those of the normal subjects, and the alcoholic subjects could have experienced a cognitive error. This phenomenon is due to the intoxicated central nervous systems of the alcoholic subjects.

Support for EU fundraising in the field of Environment & Energy - BayFOR

NASA Astrophysics Data System (ADS)

Ammerl, Thomas; Baumann, Cornelia; Reiter, Andrea; Blume, Andreas; Just, Jana; Franke, Jan

2013-04-01

The Bavarian Research Alliance (BayFOR, http://www.bayfor.org) is a private company for the support of Bavaria (Free State in the South East of Germany) as a centre for science and innovation within the European Research Area. It was set up on the initiative of the Bavarian universities to strengthen their networking at regional, national and international level while helping them to prepare to meet the requirements for European research funding. The focus is directed at the current EU Framework Programme (FP7) and the forthcoming Framework Programme for Research and Innovation "Horizon 2020", but also comprises the wide range of European programmes (e.g. FP7, LIFE+, Interreg, COST, EUREKA, ERA-Nets, IEE (CIP), LLP, Calls for tender). BayFOR is also a partner institution in the Bavarian "Haus der Forschung" (www.hausderforschung.bayern.de/en). BayFORs overall aim is to strengthen and permanently anchor the science and innovation location of Bavaria in the European Research Area through: a) Initiation of national and in particular European innovation and science partnerships from academia and business b) Improvement of innovation potential of Bavarian universities and SME c) Support in acquisition, management and dissemination of results of European and international projects in the field of research and technological development The service portfolio of the EU Funding Advisory Service reaches from the first project idea to project implementation. The minimum condition for BayFOR support is at least one partner from Bavaria (Germany) must be part of the applying consortium: a) Recommendation of funding programmes/instruments (incl. integration of relevant EU policies & directives) b) Partner search c) Project development and proposal elaboration (Online platform, Creation of consortium, Attendance at meetings, Preparation of documents, Proposal structure elaboration, Provision of templates, Editorial support: Gantt, PERT, Impact, EU added value) d) Support in the Contract negotiations with the European Commission e) Project implementation (Project management, dissemination, Science-Policy-Interface) BayFOR staff has profound R&D background, as well as knowledge and experience in disseminating project outcomes, in particular with regard to the adaptation of results to the needs of relevant target groups like science, industry/SMEs, policy makers and the public. Furthermore, BayFOR can draw on distinct experience in the management of European research projects (e.g. CLIMB, Largecells, AlpBC, GeoMol, WE-EEN, WINALP). As a partner in the network for SMEs "Enterprise Europe Network" (EEN), BayFOR offers advice and support on topics such as funding, research programs, public procurement, market penetration and the promotion of innovation at European level. Beyond, BayFOR will make use of its regional networks to promote uptake and exploitation of project results. BayFOR is also commissioned by Bavaria's State Ministry of Science, Research and the Arts to look after the Bavarian University Funding Programme for the Initiation of International Projects (BayIntAn). Our efforts are aimed at initiating or strengthening transnational collaborative research involving Bavarian universities and universities of applied sciences.

Approach to sustainable e-Infrastructures - The case of the Latin American Grid

NASA Astrophysics Data System (ADS)

Barbera, Roberto; Diacovo, Ramon; Brasileiro, Francisco; Carvalho, Diego; Dutra, Inês; Faerman, Marcio; Gavillet, Philippe; Hoeger, Herbert; Lopez Pourailly, Maria Jose; Marechal, Bernard; Garcia, Rafael Mayo; Neumann Ciuffo, Leandro; Ramos Pollan, Paul; Scardaci, Diego; Stanton, Michael

2010-05-01

The EELA (E-Infrastructure shared between Europe and Latin America) and EELA-2 (E-science grid facility for Europe and Latin America) projects, co-funded by the European Commission under FP6 and FP7, respectively, have been successful in building a high capacity, production-quality, scalable Grid Facility for a wide spectrum of applications (e.g. Earth & Life Sciences, High energy physics, etc.) from several European and Latin American User Communities. This paper presents the 4-year experience of EELA and EELA-2 in: • Providing each Member Institution the unique opportunity to benefit of a huge distributed computing platform for its research activities, in particular through initiatives such as OurGrid which proposes a so-called Opportunistic Grid Computing well adapted to small and medium Research Laboratories such as most of those of Latin America and Africa; • Developing a realistic strategy to ensure the long-term continuity of the e-Infrastructure in the Latin American continent, beyond the term of the EELA-2 project, in association with CLARA and collaborating with EGI. Previous interactions between EELA and African Grid members at events such as the IST Africa'07, 08 and 09, the International Conference on Open Access'08 and EuroAfriCa-ICT'08, to which EELA and EELA-2 contributed, have shown that the e-Infrastructure situation in Africa compares well with the Latin American one. This means that African Grids are likely to face the same problems that EELA and EELA-2 experienced, especially in getting the necessary User and Decision Makers support to create NGIs and, later, a possible continent-wide African Grid Initiative (AGI). The hope is that the EELA-2 endeavour towards sustainability as described in this presentation could help the progress of African Grids.

The 1887 earthquake and tsunami in the Ligurian Sea: analysis of coastal effects studied by numerical modeling and prototype for real-time computing

NASA Astrophysics Data System (ADS)

Monnier, Angélique; Gailler, Audrey; Loevenbruck, Anne; Heinrich, Philippe; Hébert, Hélène

2017-04-01

The February 1887 earthquake in Italy (Imperia) triggered a tsunami well observed on the French and Italian coastlines. Tsunami waves were recorded on a tide gauge in the Genoa harbour with a small, recently reappraised maximum amplitude of about 10-12 cm (crest-to-trough). The magnitude of the earthquake is still debated in the recent literature, and discussed according to available macroseismic, tectonic and tsunami data. While the tsunami waveform observed in the Genoa harbour may be well explained with a magnitude smaller than 6.5 (Hébert et al., EGU 2015), we investigate in this study whether such source models are consistent with the tsunami effects reported elsewhere along the coastline. The idea is to take the opportunity of the fine bathymetric data recently synthetized for the French Tsunami Warning Center (CENALT) to test the 1887 source parameters using refined, nested grid tsunami numerical modeling down to the harbour scale. Several source parameters are investigated to provide a series of models accounting for various magnitudes and mechanisms. This allows us to compute the tsunami effects for several coastal sites in France (Nice, Villefranche, Antibes, Mandelieu, Cannes) and to compare with observations. Meanwhile we also check the computing time of the chosen scenarios to study whether running nested grids simulation in real time can be suitable in operational context in term of computational cost for these Ligurian scenarios. This work is supported by the FP7 ASTARTE project (Assessment Strategy and Risk Reduction for Tsunamis in Europe, grant 603839 FP7) and by the French PIA TANDEM (Tsunamis in the Atlantic and English ChaNnel: Definition of the Effects through Modeling) project (grant ANR-11-RSNR-00023).

Analysis of C/E results of fission rate ratio measurements in several fast lead VENUS-F cores

NASA Astrophysics Data System (ADS)

Kochetkov, Anatoly; Krása, Antonín; Baeten, Peter; Vittiglio, Guido; Wagemans, Jan; Bécares, Vicente; Bianchini, Giancarlo; Fabrizio, Valentina; Carta, Mario; Firpo, Gabriele; Fridman, Emil; Sarotto, Massimo

2017-09-01

During the GUINEVERE FP6 European project (2006-2011), the zero-power VENUS water-moderated reactor was modified into VENUS-F, a mock-up of a lead cooled fast spectrum system with solid components that can be operated in both critical and subcritical mode. The Fast Reactor Experiments for hybrid Applications (FREYA) FP7 project was launched in 2011 to support the designs of the MYRRHA Accelerator Driven System (ADS) and the ALFRED Lead Fast Reactor (LFR). Three VENUS-F critical core configurations, simulating the complex MYRRHA core design and one configuration devoted to the LFR ALFRED core conditions were investigated in 2015. The MYRRHA related cores simulated step by step design peculiarities like the BeO reflector and in pile sections. For all of these cores the fuel assemblies were of a simple design consisting of 30% enriched metallic uranium, lead rodlets to simulate the coolant and Al2O3 rodlets to simulate the oxide fuel. Fission rate ratios of minor actinides such as Np-237, Am-241 as well as Pu-239, Pu-240, Pu-242 and U-238 to U-235 were measured in these VENUS-F critical assemblies with small fission chambers in specially designed locations, to determine the spectral indices in the different neutron spectrum conditions. The measurements have been analyzed using advanced computational tools including deterministic and stochastic codes and different nuclear data sets like JEFF-3.1, JEFF-3.2, ENDF/B7.1 and JENDL-4.0. The analysis of the C/E discrepancies will help to improve the nuclear data in the specific energy region of fast neutron reactor spectra.

Identification of nitrosamine precursors from urban drainage during storm events: A case study in southern China.

PubMed

Bei, Er; Liao, Xiaobin; Meng, Xiangting; Li, Shixiang; Wang, Jun; Sheng, Deyang; Chao, Meng; Chen, Zhuohua; Zhang, Xiaojian; Chen, Chao

2016-10-01

The drinking water sources of many cities in southern China are frequently contaminated by upstream urban drainage during storm events, which brings high concentrations of N-nitrosamine (NA) precursors and poses a threat to the safety of drinking water. We conducted two sampling campaigns during the heavy rain season in 2015 in one representative city in southern China. We detected that the concentration of N-nitrosodimethylamine formation potential (NDMA FP) in urban drainage during two storm events was 80-115 ng/L and the total formation potential concentration of nine nitrosamines (TNA9 FP) was 145-165 ng/L. To address the deteriorated water quality, 30 mg/L of powdered activated carbon (PAC) was fed into the water intake. PAC adsorption alone could remove 52% of NDMA FP and 52% of TNA FP, while the subsequent conventional process only removed 8% of TNA FP. We isolated six chemicals (N,N-benzyldimethylamine, 5-[(dimethylamino)methyl]-2-furanmethanol, N,N-dimethyl-3-aminophenol, N,N-dimethylethylamine, Ziram, and N,N-dimethylaniline) and confirmed them to be NA precursors. Among these NA precursors, Ziram was identified for the first time as a NA precursor that is formed via chloramination; its molar yield for NDMA was 6.73 ± 0.40%. Copyright © 2016 Elsevier Ltd. All rights reserved.

Developing Fast Fluorescent Protein Voltage Sensors by Optimizing FRET Interactions

PubMed Central

Sung, Uhna; Sepehri-Rad, Masoud; Piao, Hong Hua; Jin, Lei; Hughes, Thomas; Cohen, Lawrence B.; Baker, Bradley J.

2015-01-01

FRET (Förster Resonance Energy Transfer)-based protein voltage sensors can be useful for monitoring neuronal activity in vivo because the ratio of signals between the donor and acceptor pair reduces common sources of noise such as heart beat artifacts. We improved the performance of FRET based genetically encoded Fluorescent Protein (FP) voltage sensors by optimizing the location of donor and acceptor FPs flanking the voltage sensitive domain of the Ciona intestinalis voltage sensitive phosphatase. First, we created 39 different “Nabi1” constructs by positioning the donor FP, UKG, at 8 different locations downstream of the voltage-sensing domain and the acceptor FP, mKO, at 6 positions upstream. Several of these combinations resulted in large voltage dependent signals and relatively fast kinetics. Nabi1 probes responded with signal size up to 11% ΔF/F for a 100 mV depolarization and fast response time constants both for signal activation (~2 ms) and signal decay (~3 ms). We improved expression in neuronal cells by replacing the mKO and UKG FRET pair with Clover (donor FP) and mRuby2 (acceptor FP) to create Nabi2 probes. Nabi2 probes also had large signals and relatively fast time constants in HEK293 cells. In primary neuronal culture, a Nabi2 probe was able to differentiate individual action potentials at 45 Hz. PMID:26587834

Clinical usefulness of brain-computer interface-controlled functional electrical stimulation for improving brain activity in children with spastic cerebral palsy: a pilot randomized controlled trial.

PubMed

Kim, Tae-Woo; Lee, Byoung-Hee

2016-09-01

[Purpose] Evaluating the effect of brain-computer interface (BCI)-based functional electrical stimulation (FES) training on brain activity in children with spastic cerebral palsy (CP) was the aim of this study. [Subjects and Methods] Subjects were randomized into a BCI-FES group (n=9) and a functional electrical stimulation (FES) control group (n=9). Subjects in the BCI-FES group received wrist and hand extension training with FES for 30 minutes per day, 5 times per week for 6 weeks under the BCI-based program. The FES group received wrist and hand extension training with FES for the same amount of time. Sensorimotor rhythms (SMR) and middle beta waves (M-beta) were measured in frontopolar regions 1 and 2 (Fp1, Fp2) to determine the effects of BCI-FES training. [Results] Significant improvements in the SMR and M-beta of Fp1 and Fp2 were seen in the BCI-FES group. In contrast, significant improvement was only seen in the SMR and M-beta of Fp2 in the control group. [Conclusion] The results of the present study suggest that BCI-controlled FES training may be helpful in improving brain activity in patients with cerebral palsy and may be applied as effectively as traditional FES training.

Light and electron microscopic observation of regenerated fungiform taste buds in patients with recovered taste function after severing chorda tympani nerve.

PubMed

Saito, Takehisa; Ito, Tetsufumi; Narita, Norihiko; Yamada, Takechiyo; Manabe, Yasuhiro

2011-11-01

The aim of this study was to evaluate the mean number of regenerated fungiform taste buds per papilla and perform light and electron microscopic observation of taste buds in patients with recovered taste function after severing the chorda tympani nerve during middle ear surgery. We performed a biopsy on the fungiform papillae (FP) in the midlateral region of the dorsal surface of the tongue from 5 control volunteers (33 total FP) and from 7 and 5 patients with and without taste recovery (34 and 29 FP, respectively) 3 years 6 months to 18 years after surgery. The specimens were observed by light and transmission electron microscopy. The taste function was evaluated by electrogustometry. The mean number of taste buds in the FP of patients with completely recovered taste function was significantly smaller (1.9 +/- 1.4 per papilla; p < 0.01) than that of the control subjects (3.8 +/- 2.2 per papilla). By transmission electron microscopy, 4 distinct types of cell (type I, II, III, and basal cells) were identified in the regenerated taste buds. Nerve fibers and nerve terminals were also found in the taste buds. It was clarified that taste buds containing taste cells and nerve endings do regenerate in the FP of patients with recovered taste function.

Primary Generators of Visually Evoked Field Potentials Recorded in the Macaque Auditory Cortex.

PubMed

Kajikawa, Yoshinao; Smiley, John F; Schroeder, Charles E

2017-10-18

Prior studies have reported "local" field potential (LFP) responses to faces in the macaque auditory cortex and have suggested that such face-LFPs may be substrates of audiovisual integration. However, although field potentials (FPs) may reflect the synaptic currents of neurons near the recording electrode, due to the use of a distant reference electrode, they often reflect those of synaptic activity occurring in distant sites as well. Thus, FP recordings within a given brain region (e.g., auditory cortex) may be "contaminated" by activity generated elsewhere in the brain. To determine whether face responses are indeed generated within macaque auditory cortex, we recorded FPs and concomitant multiunit activity with linear array multielectrodes across auditory cortex in three macaques (one female), and applied current source density (CSD) analysis to the laminar FP profile. CSD analysis revealed no appreciable local generator contribution to the visual FP in auditory cortex, although we did note an increase in the amplitude of visual FP with cortical depth, suggesting that their generators are located below auditory cortex. In the underlying inferotemporal cortex, we found polarity inversions of the main visual FP components accompanied by robust CSD responses and large-amplitude multiunit activity. These results indicate that face-evoked FP responses in auditory cortex are not generated locally but are volume-conducted from other face-responsive regions. In broader terms, our results underscore the caution that, unless far-field contamination is removed, LFPs in general may reflect such "far-field" activity, in addition to, or in absence of, local synaptic responses. SIGNIFICANCE STATEMENT Field potentials (FPs) can index neuronal population activity that is not evident in action potentials. However, due to volume conduction, FPs may reflect activity in distant neurons superimposed upon that of neurons close to the recording electrode. This is problematic as the default assumption is that FPs originate from local activity, and thus are termed "local" (LFP). We examine this general problem in the context of previously reported face-evoked FPs in macaque auditory cortex. Our findings suggest that face-FPs are indeed generated in the underlying inferotemporal cortex and volume-conducted to the auditory cortex. The note of caution raised by these findings is of particular importance for studies that seek to assign FP/LFP recordings to specific cortical layers. Copyright © 2017 the authors 0270-6474/17/3710139-15$15.00/0.

Primary Generators of Visually Evoked Field Potentials Recorded in the Macaque Auditory Cortex

PubMed Central

Smiley, John F.; Schroeder, Charles E.

2017-01-01

Prior studies have reported “local” field potential (LFP) responses to faces in the macaque auditory cortex and have suggested that such face-LFPs may be substrates of audiovisual integration. However, although field potentials (FPs) may reflect the synaptic currents of neurons near the recording electrode, due to the use of a distant reference electrode, they often reflect those of synaptic activity occurring in distant sites as well. Thus, FP recordings within a given brain region (e.g., auditory cortex) may be “contaminated” by activity generated elsewhere in the brain. To determine whether face responses are indeed generated within macaque auditory cortex, we recorded FPs and concomitant multiunit activity with linear array multielectrodes across auditory cortex in three macaques (one female), and applied current source density (CSD) analysis to the laminar FP profile. CSD analysis revealed no appreciable local generator contribution to the visual FP in auditory cortex, although we did note an increase in the amplitude of visual FP with cortical depth, suggesting that their generators are located below auditory cortex. In the underlying inferotemporal cortex, we found polarity inversions of the main visual FP components accompanied by robust CSD responses and large-amplitude multiunit activity. These results indicate that face-evoked FP responses in auditory cortex are not generated locally but are volume-conducted from other face-responsive regions. In broader terms, our results underscore the caution that, unless far-field contamination is removed, LFPs in general may reflect such “far-field” activity, in addition to, or in absence of, local synaptic responses. SIGNIFICANCE STATEMENT Field potentials (FPs) can index neuronal population activity that is not evident in action potentials. However, due to volume conduction, FPs may reflect activity in distant neurons superimposed upon that of neurons close to the recording electrode. This is problematic as the default assumption is that FPs originate from local activity, and thus are termed “local” (LFP). We examine this general problem in the context of previously reported face-evoked FPs in macaque auditory cortex. Our findings suggest that face-FPs are indeed generated in the underlying inferotemporal cortex and volume-conducted to the auditory cortex. The note of caution raised by these findings is of particular importance for studies that seek to assign FP/LFP recordings to specific cortical layers. PMID:28924008

Precursors of Halobenzoquinones and Their Removal During Drinking Water Treatment Processes.

PubMed

Wang, Wei; Qian, Yichao; Jmaiff, Lindsay K; Krasner, Stuart W; Hrudey, Steve E; Li, Xing-Fang

2015-08-18

Halobenzoquinones (HBQs) widely occur in drinking water treatment plant (DWTP) effluents; however, HBQ precursors and their removal by treatments remain unclear. Thus, we have investigated HBQ precursors in plant influents and their removal by each treatment before chlorination in nine DWTPs. The levels of HBQ precursors were determined using formation potential (FP) tests for 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,3,6-trichloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ), and 2,6-dibromo-1,4-benzoquinone (DBBQ). HBQ precursors were present in all plant influents. DCBQ precursors were the most abundant (DCBQ FP up to 205 ng/L). Coagulation removed dissolved organic carbon (DOC) (up to 56%) and HBQ precursors (up to 39% for DCBQ). The level of removal of DOC was significantly greater than the level of removal of HBQ FP, suggesting that organic matter removed by coagulation had a high proportion of non-HBQ-precursor material. Granular activated carbon (GAC) decreased the level of HBQ FPs by 10-20%, where DOC removal was only 0.2-4.7%, suggesting that the GAC was not in the adsorption mode and biodegradation of HBQ precursors may have been occurring. Ozonation destroyed/transformed HBQ FPs by 10-30%, whereas anthracite/sand filtration and UV irradiation appeared to have no impact. The results demonstrated that the combined treatments did not substantially reduce HBQ precursor levels in water.

Brokerage services for Earth Science data: the EuroGEOSS legacy (Invited)

NASA Astrophysics Data System (ADS)

Nativi, S.; Craglia, M.; Pearlman, J.

2013-12-01

Global sustainability research requires an integrated multidisciplinary effort underpinned by a collaborative environment discovering and accessing heterogeneous data across disciplines. Traditionally, interoperability has been achieved by implementing federation of systems. The federating approach entails the adoption of a set of common technologies and standards. This presentation argues that for complex (and uncontrolled) environments (such as global, multidisciplinary, and voluntary-based infrastructures) federated solutions must be completed and enhanced by a brokering approach -making available a set of brokerage services. In fact, brokerage services allows a cyber-infrastructure to lower entry barriers (for both data producers and users) and to better address the different domain specificities. The brokering interoperability approach was successfully experimented by the EuroGEOSS project, funded by the European Commission in the FP7 framework (see http://www.eurogeoss.eu). The EuroGEOSS Brokering framework provided the EuroGEOSS Capacity with multidisciplinary interoperability functionalities. This platform was developed applying several of the principles/requirements that characterize the System of Systems (SoS) approach and the Internet of Services (IoS) philosophy. The framework consists of three main brokers (middleware components implementing intermediation and harmonization services): a basic Discovery Broker, an advanced Semantic Discovery Broker, and an Access Broker. They are empowered by a suite of tools developed by the ESSI-lab of the CNR-IIA, called: GI-cat, GI-sem, and GI-axe. The EuroGEOSS brokering framework was considered and successfully adopted by cross-disciplinary initiatives (notably GEOSS: Global Earth Observation System of Systems). The brokerage services have been advanced and extended; the new brokering framework is called GEO DAB (Discovery and Access Broker). New brokerage services have been developed in the framework of other European Commission funded projects (e.g. GeoViQua). More recently, the NSF EarthCube initiative decided to fund a project dealing with brokerage services. In the framework of the GEO AIP-6 (Architecture Implementation Pilot -phase 6), the presented brokerage platform has been used by the Water Working Group to carry out improved data access for parameterization and model development.

Comparison of a laboratory grade force platform with a Nintendo Wii Balance Board on measurement of postural control in single-leg stance balance tasks.

PubMed

Huurnink, Arnold; Fransz, Duncan P; Kingma, Idsart; van Dieën, Jaap H

2013-04-26

Training and testing of balance have potential applications in sports and medicine. Laboratory grade force plates (FP) are considered the gold standard for the measurement of balance performance. Measurements in these systems are based on the parameterization of center of pressure (CoP) trajectories. Previous research validated the inexpensive, widely available and portable Nintendo Wii Balance Board (WBB). The novelty of the present study is that FP and WBB are compared on CoP data that was collected simultaneously, by placing the WBB on the FP. Fourteen healthy participants performed ten sequences of single-leg stance tasks with eyes open (EO), eyes closed (EC) and after a sideways hop (HOP). Within trial comparison of the two systems showed small root-mean-square differences for the CoP trajectories in the x and y direction during the three tasks (mean±SD; EO: 0.33±0.10 and 0.31±0.16 mm; EC: 0.58±0.17 and 0.63±0.19 mm; HOP: 0.74±0.34 and 0.74±0.27 mm, respectively). Additionally, during all 420 trials, comparison of FP and WBB revealed very high Pearson's correlation coefficients (r) of the CoP trajectories (x: 0.999±0.002; y: 0.998±0.003). A general overestimation was found on the WBB compared to the FP for 'CoP path velocity' (EO: 5.3±1.9%; EC: 4.0±1.4%; HOP: 4.6±1.6%) and 'mean absolute CoP sway' (EO: 3.5±0.7%; EC: 3.7±0.5%; HOP: 3.6±1.0%). This overestimation was highly consistent over the 140 trials per task (r>0.996). The present findings demonstrate that WBB is sufficiently accurate in quantifying CoP trajectory, and overall amplitude and velocity during single-leg stance balance tasks. Copyright © 2013 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gopishankar, N; Agarwal, Priyanka; Bisht, Raj Kishor

Purpose: To evaluate forward and inverse planning methods for acoustic neuroma cases treated in Gamma Knife Perfexion. Methods: Five patients with acoustic neuroma tumour abutting brainstem were planned twice in LGP TPS (Version 10.1) using TMR10 algorithm. First plan was entirely based on forward planning (FP) in which each shot was chosen manually. Second plan was generated using inverse planning (IP) for which planning parameters like coverage, selectivity, gradient index (GI) and beam-on time threshold were set. Number of shots in IP was automatically selected by objective function using iterative process. In both planning methods MRI MPRAGE sequence images weremore » used for tumour localization and planning. A planning dose of 12Gy at 50% isodose level was chosen. Results and Discussion: Number of shots used in FP was greater than IP and beam-on time in FP was in average 1.4 times more than IP. One advantage of FP was that the brainstem volume subjected to 6Gy dose (25% isodose) was less in FP than IP. Our results showed use of more number of shots as in FP results in GI less than or equal to 2.55 which is close to its lower limit. Dose homogeneity index (DHI) analysis of FP and IP showed average values of 0.59 and 0.67 respectively. General trend in GK for planning in acoustic neuroma cases is to use small collimator shots to avoid dose to adjacent critical structures. More number of shots and prolonged treatment time causes inconvenience to the patients. Similarly overuse of automatic shot shaping as in IP results in increased scatter dose. A compromise is required in shot selection for these cases. Conclusion: IP method could be used in acoustic neuroma cases to decrease treatment time provided the source sector openings near brainstem are shielded or adjusted appropriately to reduce brainstem dose.« less

What keeps family physicians busy in Portugal? A multicentre observational study of work other than direct patient contacts

PubMed Central

Granja, Mónica; Ponte, Carla; Cavadas, Luís Filipe

2014-01-01

Objectives To quantify the time spent by family physicians (FP) on tasks other than direct patient contact, to evaluate job satisfaction, to analyse the association between time spent on tasks and physician characteristics, the association between the number of tasks performed and physician characteristics and the association between time spent on tasks and job satisfaction. Design Cross-sectional, using time-and-motion techniques. Two workdays were documented by direct observation. A significance level of 0.05 was adopted. Setting Multicentric in 104 Portuguese family practices. Participants A convenience sample of FP, with lists of over 1000 patients, teaching senior medical students and first-year family medicine residents in 2012, was obtained. Of the 217 FP invited to participate, 155 completed the study. Main outcomes measured Time spent on tasks other than direct patient contact and on the performance of more than one task simultaneously, the number of direct patient contacts in the office, the number of indirect patient contacts, job satisfaction, demographic and professional characteristics associated with time spent on tasks and the number of different tasks performed, and the association between time spent on tasks and job satisfaction. Results FP (n=155) spent a mean of 143.6 min/day (95% CI 135.2 to 152.0) performing tasks such as prescription refills, teaching, meetings, management and communication with other professionals (33.4% of their workload). FP with larger patient lists spent less time on these tasks (p=0.002). Older FP (p=0.021) and those with larger lists (p=0.011) performed fewer tasks. The mean job satisfaction score was 3.5 (out of 5). No association was found between job satisfaction and time spent on tasks. Conclusions FP spent one-third of their workday in coordinating care, teaching and managing. Time devoted to these tasks decreases with increasing list size and physician age. PMID:24934208

An evaluation of a family planning mobile job aid for community health workers in Tanzania.

PubMed

Braun, Rebecca; Lasway, Christine; Agarwal, Smisha; L'Engle, Kelly; Layer, Erica; Silas, Lucy; Mwakibete, Anna; Kudrati, Mustafa

2016-07-01

The global rapid growth in mobile technology provides unique opportunities to support community health workers (CHWs) in providing family planning (FP) services. FHI 360, Pathfinder International and D-tree International developed an evidence-based mobile job aid to support CHW counseling, screening, service provision and referrals, with mobile forms for client and service data, and text-message reporting and reminders. The purpose of this study is to evaluate the acceptability and potential benefits to service quality from the perspective of CHWs and their clients. The mobile job aid was piloted in Dar es Salaam, Tanzania. Data collection tools included a demographic survey of all 25 CHWs trained to use the mobile job aid, in-depth interviews with 20 of the CHWs after 3 months and a survey of 176 clients who received FP services from a CHW using the mobile job aid after 6 months. Both CHWs and their clients reported that the mobile job aid was a highly acceptable FP support tool. CHWs perceived benefits to service quality, including timelier and more convenient care; better quality of information; increased method choice; and improved privacy, confidentiality and trust with clients. Most clients discussed multiple FP methods with CHWs; only 1 in 10 clients reported discussion of all 9 methods. This research suggests that mobile phones can be effective tools to support CHWs with FP counseling, screening and referrals, data collection and reporting, and communication. Challenges remain to support informed contraceptive choice. Future research should focus on implementation, including scale-up and sustainability. Mobile job aids can uniquely enhance FP service provision at the community level through adherence to standard protocols, real-time feedback and technical assistance, and provision of confidential care. This study can inform future efforts to support and expand the role of CHWs in increasing FP access and informed contraceptive choice. Copyright © 2016 Elsevier Inc. All rights reserved.

Rice Cakes Containing Dietary Fiber Supplemented with or without Artemisia Annua and Gynura Procumbens Merr. Alleviated the Risk Factors of Metabolic Syndrome.

PubMed

Yoon, Na Rae; Yoon, Sun; Lee, Seung-Min

2016-04-01

We investigated whether the consumption of Korean rice cakes enriched with dietary fiber with or without polyphenol rich plants might decrease the risk factors of metabolic syndrome (MetS). Rice cakes were manufactured using fructooligosaccharides, resistant starch, and psyllium as sources of dietary fibers with and without polyphenol rich Artemisia annua and Gynura procumbens Merr. (RC+FP and RC+F, respectively), and prepared in three forms (songpyeon, seolgidduk, and chaldduk). Ninety subjects with at least one MetS risk factor were recruited for 6 weeks of dietary intervention. Sixty subjects were finally included for the analysis. Compared to the initial values, RC+FP group had decreased levels of fasting blood glucose (FBG), HOMA-IR and blood pressure after 6 weeks, whereas RC+F group didn't have significant changes in them. Regarding the improvement of individual MetS risk factors, RC+FP group showed significant reduction in FBG and blood pressures but RC+F group only had reduction in systolic blood pressure. After the intervention, a reduction in the number of MetS risk factors was greatert in the RC+FP group than in the RC+F group. In conclusion, Dietary fiber enriched rice cakes with or without polyphenols decreased the number and/or the levels of MetS risk factors. Polyphenol rich plant components may provide additional health benefits in controlling FBG and blood pressure.

Rice Cakes Containing Dietary Fiber Supplemented with or without Artemisia Annua and Gynura Procumbens Merr. Alleviated the Risk Factors of Metabolic Syndrome

PubMed Central

2016-01-01

We investigated whether the consumption of Korean rice cakes enriched with dietary fiber with or without polyphenol rich plants might decrease the risk factors of metabolic syndrome (MetS). Rice cakes were manufactured using fructooligosaccharides, resistant starch, and psyllium as sources of dietary fibers with and without polyphenol rich Artemisia annua and Gynura procumbens Merr. (RC+FP and RC+F, respectively), and prepared in three forms (songpyeon, seolgidduk, and chaldduk). Ninety subjects with at least one MetS risk factor were recruited for 6 weeks of dietary intervention. Sixty subjects were finally included for the analysis. Compared to the initial values, RC+FP group had decreased levels of fasting blood glucose (FBG), HOMA-IR and blood pressure after 6 weeks, whereas RC+F group didn't have significant changes in them. Regarding the improvement of individual MetS risk factors, RC+FP group showed significant reduction in FBG and blood pressures but RC+F group only had reduction in systolic blood pressure. After the intervention, a reduction in the number of MetS risk factors was greatert in the RC+FP group than in the RC+F group. In conclusion, Dietary fiber enriched rice cakes with or without polyphenols decreased the number and/or the levels of MetS risk factors. Polyphenol rich plant components may provide additional health benefits in controlling FBG and blood pressure. PMID:27152297

Case descriptions of fibropapillomatosis in rehabilitating loggerhead sea turtles Caretta caretta in the southeastern USA.

PubMed

Page-Karjian, Annie; Norton, Terry M; Harms, Craig; Mader, Doug; Herbst, Larry H; Stedman, Nancy; Gottdenker, Nicole L

2015-08-20

Fibropapillomatosis (FP) is a debilitating neoplastic disease that affects all species of hard-shelled sea turtles, including loggerhead turtles Caretta caretta. FP can represent an important clinical concern in rehabilitating turtles, since managing these infectious lesions often requires special husbandry provisions including quarantine, and FP may affect clinical progression, extend rehabilitation duration, and complicate prognoses. Here we describe cases of rehabilitating loggerhead turtles with FP (designated FP+). Medical records of FP+ loggerhead cases from 3 sea turtle rehabilitation facilities in the southeastern USA were reviewed. Between 2001 and 2014, FP was observed in 8 of 818 rehabilitating loggerhead turtles (0.98% overall prevalence in admitted patients). FP+ loggerhead size classes represented were large juvenile (straight carapace length, SCL: 58.1-80 cm; n=7) and adult (SCL>87 cm; n=1). Three turtles presented with FP, and 5 developed tumors during rehabilitation within a range of 45 to 319 d. Sites of new tumor growth included the eyes, sites of trauma, neck, and glottis. FP+ turtles were scored as mildly (3/8), moderately (4/8), or heavily (1/8) afflicted. The mean total time in rehabilitation was 476±355 d (SD) (range: 52-1159 d). Six turtles were released without visible evidence of FP, 1 turtle was released with mild FP, and 1 turtle with internal FP was euthanized. Clinical decision-making for FP+ loggerhead patients can be aided by such information as time to tumor development, anatomic locations to monitor for new tumor growth, husbandry considerations, diagnostic and treatment options, and comparisons to FP in rehabilitating green turtles Chelonia mydas.

Inter-crystal scatter identification for a depth-sensitive detector using support vector machine for small animal positron emission tomography

NASA Astrophysics Data System (ADS)

Yoshida, Eiji; Kitamura, Keishi; Kimura, Yuichi; Nishikido, Fumihiko; Shibuya, Kengo; Yamaya, Taiga; Murayama, Hideo

2007-02-01

In a conventional positron emission tomography (PET) detector, detected events are projected onto a 2D position histogram by an Anger calculation for crystal identification. However, the measured histogram is affected by inter-crystal scatterings (ICS) which occur in the entire detector. Peaks which are projected for each crystal in the histogram are blurred, and this causes ICS mispositioning. A depth-of-interaction (DOI) detector has been developed for the small animal PET scanner jPET-RD. This DOI detector uses 32×32 crystals with four layers and a 256-channel multi-anode flat panel photomultiplier tube (FP-PMT) which was developed by Hamamatsu Photonics K.K. Each crystal element is 1.45×1.45×4.5 mm 3. The FP-PMT has a large detective area (49×49 mm 2) and a small anode pitch (3.04 mm). Therefore, the FP-PMT can extensively trace the behavior of incident γ rays in the crystals including ICS event. We, therefore, propose a novel method for ICS estimation using a statistical pattern recognition algorithm based on a support vector machine (SVM). In this study, we applied the SVM for discriminating photoelectric events from ICS events generated from multiple-anode outputs. The SVM was trained by uniform irradiation events generated from a detector simulator using a Monte Carlo calculation. The success rate for ICS event identification is about 78% for non-training data. The SVM can achieve a true subtraction of ICS events from measured events, and it is also useful for random correction in PET.

Training: more user friendly.

PubMed

Horibe, N

1994-03-01

China launched its family planning program in 1971 by initially focusing on public information campaigns and providing services to married couples nationwide. It eventually instituted programs to improve maternal and child health/family planning (MCH/FP) through better quality service. Such programs introduced interpersonal communication and counseling to improve quality service. In 1990, with help from UNICEF and the United Nations Population Fund [UNFPA], the Ministry of Public Health (MOPH) implemented a project to improve MCH/FP in 300 of China's poorest counties. Its training activities are chiefly for physicians and emphasize safe motherhood, breast feeding, diarrhea, case management of acute respiratory infection, and FP. Interpersonal communication and counseling has been included in each of these areas. Also with UNFPA assistance, the State Family Planning Commission (SFPC) began a project in 1991, targeting township and village family planning workers, which concentrates on interpersonal communication and counseling in its service delivery system. MOPH and SFPC are China's 2 vertical service delivery systems and they do not cooperate at the central level. At the lower level, however, they work together in interpersonal communication and counseling training. The training uses the participatory training method, which encourages two-way communication. The curriculum addresses motivation; education and counseling; perception, values, and misconceptions; verbal and nonverbal communications; interviewing and listening skills; and how to help the client's decision making. Feedback is very important. The participatory method training class should not exceed 50 participants, but financial constraints make this difficult in China. Short-term benefits of the training are: inspiration to trainers, increased sensitivity to the clients' needs and feelings, and exposure to an international professional work ethic and practice.

Rapid earthquake hazard and loss assessment for Euro-Mediterranean region

NASA Astrophysics Data System (ADS)

Erdik, Mustafa; Sesetyan, Karin; Demircioglu, Mine; Hancilar, Ufuk; Zulfikar, Can; Cakti, Eser; Kamer, Yaver; Yenidogan, Cem; Tuzun, Cuneyt; Cagnan, Zehra; Harmandar, Ebru

2010-10-01

The almost-real time estimation of ground shaking and losses after a major earthquake in the Euro-Mediterranean region was performed in the framework of the Joint Research Activity 3 (JRA-3) component of the EU FP6 Project entitled "Network of Research Infra-structures for European Seismology, NERIES". This project consists of finding the most likely location of the earthquake source by estimating the fault rupture parameters on the basis of rapid inversion of data from on-line regional broadband stations. It also includes an estimation of the spatial distribution of selected site-specific ground motion parameters at engineering bedrock through region-specific ground motion prediction equations (GMPEs) or physical simulation of ground motion. By using the Earthquake Loss Estimation Routine (ELER) software, the multi-level methodology developed for real time estimation of losses is capable of incorporating regional variability and sources of uncertainty stemming from GMPEs, fault finiteness, site modifications, inventory of physical and social elements subjected to earthquake hazard and the associated vulnerability relationships.

Downscaling of RCM outputs for representative catchments in the Mediterranean region, for the 1951-2100 time-frame

NASA Astrophysics Data System (ADS)

Deidda, Roberto; Marrocu, Marino; Pusceddu, Gabriella; Langousis, Andreas; Mascaro, Giuseppe; Caroletti, Giulio

2013-04-01

Within the activities of the EU FP7 CLIMB project (www.climb-fp7.eu), we developed downscaling procedures to reliably assess climate forcing at hydrologically relevant scales, and applied them to six representative hydrological basins located in the Mediterranean region: Riu Mannu and Noce in Italy, Chiba in Tunisia, Kocaeli in Turkey, Thau in France, and Gaza in Palestine. As a first step towards this aim, we used daily precipitation and temperature data from the gridded E-OBS project (www.ecad.eu/dailydata), as reference fields, to rank 14 Regional Climate Model (RCM) outputs from the ENSEMBLES project (http://ensembles-eu.metoffice.com). The four best performing model outputs were selected, with the additional constraint of maintaining 2 outputs obtained from running different RCMs driven by the same GCM, and 2 runs from the same RCM driven by different GCMs. For these four RCM-GCM model combinations, a set of downscaling techniques were developed and applied, for the period 1951-2100, to variables used in hydrological modeling (i.e. precipitation; mean, maximum and minimum daily temperatures; direct solar radiation, relative humidity, magnitude and direction of surface winds). The quality of the final products is discussed, together with the results obtained after applying a bias reduction procedure to daily temperature and precipitation fields.

Long-term hormonal contraceptive use is associated with a reversible suppression of antral follicle count and a break from hormonal contraception may improve oocyte yield.

PubMed

Letourneau, Joseph M; Cakmak, Hakan; Quinn, Molly; Sinha, Nikita; I Cedars, Marcelle; Rosen, Mitchell P

2017-09-01

Unlike infertility, patients presenting for fertility preservation (FP) are often using combined hormonal contraceptives (CHC). We studied whether long-term (≥6 months) CHC use is associated with reversible suppression of antral follicle count (AFC). This is a longitudinal study of FP cycles from 2012 to 2016. We studied three groups: those without CHC exposure (NO CHC), those with CHC usage with a CHC break (BREAK), and without a break (NO BREAK) prior to ovarian stimulation. We assessed ovarian reserve by AFC at initial consultation and discussed the possibility of CHC suppression of AFC. Patients chose between ovarian stimulation with no CHC break versus ovarian stimulation after a CHC break. AFC was measured serially in the BREAK group. We assessed whether AFC suppression was reversed in the BREAK group. Total oocyte yield was compared among the NO CHC, BREAK, and NO BREAK groups. T tests, ANOVA, and linear/logistic regressions were used. Seven hundred forty-three women underwent FP. Twenty-one percent (n = 154) were taking long-term CHC (≥6 months). AFC suppression was more likely with CHC use (OR 1.6, 95% CI 1.1-2.4, P = 0.011). The BREAK group (n = 79) stopped CHC for an average of 4 months. AFC improvement started at 1 month and plateaued at approximately 6- to 7-month break. The BREAK group had approximately twice as many oocytes per initial AFC as NO BREAK (2.8 ± 3.8 vs. 1.4 ± 0.9, P < 0.001). When women present for FP on CHC, AFC may be suppressed. A CHC break of several months is associated with an increase in AFC and a potential improvement in overall egg yield.

Integrated Network Testbed for Energy Grid Research and Technology

Science.gov Websites

Network Testbed for Energy Grid Research and Technology Experimentation Project Under the Integrated Network Testbed for Energy Grid Research and Technology Experimentation (INTEGRATE) project, NREL and partners completed five successful technology demonstrations at the ESIF. INTEGRATE is a $6.5-million, cost

In vitro biofilm formation on resin-based composites after different finishing and polishing procedures.

PubMed

Cazzaniga, Gloria; Ottobelli, Marco; Ionescu, Andrei C; Paolone, Gaetano; Gherlone, Enrico; Ferracane, Jack L; Brambilla, Eugenio

2017-12-01

To evaluate the influence of surface treatments of different resin-based composites (RBCs) on S. mutans biofilm formation. 4 RBCs (microhybrid, nanohybrid, nanofilled, bulk-filled) and 6 finishing-polishing (F/P) procedures (open-air light-curing, light-curing against Mylar strip, aluminum oxide discs, one-step rubber point, diamond bur, multi-blade carbide bur) were evaluated. Surface roughness (SR) (n=5/group), gloss (n=5/group), scanning electron microscopy morphological analysis (SEM), energy-dispersive X-ray spectrometry (EDS) (n=3/group), and S. mutans biofilm formation (n=16/group) were assessed. EDS analysis was repeated after the biofilm assay. A morphological evaluation of S. mutans biofilm was also performed using confocal laser-scanning microscopy (CLSM) (n=2/group). The data were analyzed using Wilcoxon (SR, gloss) and two-way ANOVA with Tukey as post-hoc tests (EDS, biofilm formation). F/P procedures as well as RBCs significantly influenced SR and gloss. While F/P procedures did not significantly influence S. mutans biofilm formation, a significant influence of RBCs on the same parameter was found. Different RBCs showed different surface elemental composition. Both F/P procedures and S. mutans biofilm formation significantly modified this parameter. The tested F/P procedures significantly influenced RBCs surface properties but did not significantly affect S. mutans biofilm formation. The significant influence of the different RBCs tested on S. mutans biofilm formation suggests that material characteristics and composition play a greater role than SR. F/P procedures of RBCs may unexpectedly play a minor role compared to that of the restoration material itself in bacterial colonization. Copyright © 2017 Elsevier Ltd. All rights reserved.

Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos.

PubMed

Sugimura, S; Narita, K; Yamashiro, H; Sugawara, A; Shoji, T; Terashita, Y; Nishimori, K; Konno, T; Yoshida, M; Sato, E

2009-09-01

Interspecies somatic cell nucleus transfer (iSCNT) could be a useful bioassay system for assessing the ability of mammalian somatic cells to develop into embryos. To examine this possibility, we performed canine iSCNT using porcine oocytes, allowed to mature in vitro, as recipients. Canine fibroblasts from the tail tips and dewclaws of a female poodle (Fp) and a male poodle (Mp) were used as donors. We demonstrated that the use of porcine oocytes induced blastocyst formation in the iSCNT embryos cultured in porcine zygote medium-3. In Fp and Mp, the rate of blastocyst formation from cleaved embryos (Fp: 6.3% vs. 22.4%; and Mp: 26.1% vs. 52.4%) and the number of cells at the blastocyst stage (Fp: 30.7 vs. 60.0; and Mp: 27.2 vs. 40.1) were higher in the embryos derived from dewclaw cells than in those derived from tail-tip cells (P<0.05). The use of donor cells of any type in later passages decreased the rate of blastocyst formation. Treatment with trichostatin-A did not improve the rate of blastocyst formation from cleaved dewclaw cell-derived embryos but did so in the embryos derived from the tail-tip cells of Fp. Only blastocysts derived from dewclaw cells of Mp developed outgrowths. However, outgrowth formation was retrieved in the embryos derived from dewclaw cells of Fp by aggregation at the 4-cell stage. We inferred that iSCNT performed using porcine oocytes as recipients could represent a novel bioassay system for evaluating the developmental competence of canine somatic cells.

Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma Control

PubMed Central

Stockmann, Chris; Fassl, Bernhard; Gaedigk, Roger; Nkoy, Flory; Uchida, Derek A.; Monson, Steven; Reilly, Christopher A.; Leeder, J. Steven; Yost, Garold S.; Ward, Robert M.

2012-01-01

Objective To determine the relationship between allelic variations in genes involved in fluticasone propionate (FP) metabolism and asthma control among children with asthma managed with inhaled FP. Study design The relationship between variability in asthma control scores and genetic variation in drug metabolism was assessed by genotyping nine single nucleotide polymorphisms (SNPs) in CYP3A4, CYP3A5, and CYP3A7. Genotype information was compared with asthma control scores (0 = well-controlled to 15 = poorly-controlled), determined by using a questionnaire modified from the National Heart Lung and Blood Institute Expert Panel 3 guidelines. Results Our study cohort was comprised of 734 children with asthma (mean age 8.8 ± 4.3 years), who were predominantly male (61%) and non-Hispanic Whites (53%); 413 children (56%) were receiving inhaled glucocorticoids daily, of which FP was prescribed most frequently (65%). Among the children receiving daily FP, SNPs in the genes CYP3A5 and CYP3A7 were not associated with asthma control scores. In contrast, asthma control scores were significantly improved among 20 (7%) children with the CYP3A4*22 allele (median 3, range 0-6), as compared with the 201 patients without the CYP3A4*22 allele (median 4, range 0-15) (P=0.02). The presence of CYP3A4*22 was associated with improved asthma control scores by 2.1 points (95% CI: 0.5-3.8). Conclusions The presence of CYP3A4*22, which is associated with decreased hepatic CYP3A4 expression and activity, was accompanied by improved asthma control among FP treated children. Decreased CYP3A4 activity may improve asthma control with inhaled FP. PMID:23290512

Contour-Based Corner Detection and Classification by Using Mean Projection Transform

PubMed Central

Kahaki, Seyed Mostafa Mousavi; Nordin, Md Jan; Ashtari, Amir Hossein

2014-01-01

Image corner detection is a fundamental task in computer vision. Many applications require reliable detectors to accurately detect corner points, commonly achieved by using image contour information. The curvature definition is sensitive to local variation and edge aliasing, and available smoothing methods are not sufficient to address these problems properly. Hence, we propose Mean Projection Transform (MPT) as a corner classifier and parabolic fit approximation to form a robust detector. The first step is to extract corner candidates using MPT based on the integral properties of the local contours in both the horizontal and vertical directions. Then, an approximation of the parabolic fit is calculated to localize the candidate corner points. The proposed method presents fewer false-positive (FP) and false-negative (FN) points compared with recent standard corner detection techniques, especially in comparison with curvature scale space (CSS) methods. Moreover, a new evaluation metric, called accuracy of repeatability (AR), is introduced. AR combines repeatability and the localization error (Le) for finding the probability of correct detection in the target image. The output results exhibit better repeatability, localization, and AR for the detected points compared with the criteria in original and transformed images. PMID:24590354

Contour-based corner detection and classification by using mean projection transform.

PubMed

Kahaki, Seyed Mostafa Mousavi; Nordin, Md Jan; Ashtari, Amir Hossein

2014-02-28

Image corner detection is a fundamental task in computer vision. Many applications require reliable detectors to accurately detect corner points, commonly achieved by using image contour information. The curvature definition is sensitive to local variation and edge aliasing, and available smoothing methods are not sufficient to address these problems properly. Hence, we propose Mean Projection Transform (MPT) as a corner classifier and parabolic fit approximation to form a robust detector. The first step is to extract corner candidates using MPT based on the integral properties of the local contours in both the horizontal and vertical directions. Then, an approximation of the parabolic fit is calculated to localize the candidate corner points. The proposed method presents fewer false-positive (FP) and false-negative (FN) points compared with recent standard corner detection techniques, especially in comparison with curvature scale space (CSS) methods. Moreover, a new evaluation metric, called accuracy of repeatability (AR), is introduced. AR combines repeatability and the localization error (Le) for finding the probability of correct detection in the target image. The output results exhibit better repeatability, localization, and AR for the detected points compared with the criteria in original and transformed images.

[Studying the fertility peak in Beijing].

PubMed

Zhong, L

1989-07-01

Beijing, China, is experiencing a baby boom in response to 2 periods of large population increase in the mid-1950s and early 1960s. The average number of annual births was 220,000 in the first period and 269,000 in the second period. The causes of the large increase in the population in the first period were an improvement of health conditions which led to a reduction in mortality, immigration flow, and an erroneous population policy. The causes in the second period were recuperative fertility after three years of natural calamity and increased fertility among immigrants. Net migration had an important role in population growth these two periods; it also will have an important impact in future population changes. According to population projections, another baby boom is expected to occur before the end of the end of the century. During the up-coming baby boom period, 1.54 million births are expected, 190,000 per annum. The average increase in population size is expected to 127,000 per year. In the peak year, it may be around 200,000. Thanks to the family planning (FP) program the occurrence of the third baby boom in Beijing has been postponed and the duration will be shortened. From 1972 to 1982, 2.57 million births was averted due to FP, which drastically reduced pressure on the demand for resources and on the momentum of the next baby boom. Another baby booms is not expected during the early half of the 21st century, although an elevated birth rate within the range of normal fluctuation is predicted. The projection was based on the assumption of restricted migration and the enforcement of the FP program. The realization of the projected population will depend on deferred marriage, deferred child-bearing, prolonged birth spacing, the prevention of high parity fertility, the maintenance of the current population policy, and control over the reproductive behavior of the new migrant population.

BREAD: a European coordination action for broadband for all

NASA Astrophysics Data System (ADS)

Van Daele, P.

2006-10-01

The BREAD - co-ordination action, funded by the European Commission through the Framework 6 Programme (FP6) aims at developing a multi-disciplinary approach for the realization of the 'Broadband for All' concept within Europe, bringing together societal, economic, regulatory and technological disciplines and presenting information from regional "success stories" of actual deployment. The EU objective of achieving "Broadband for All" will not be reached by solely a 'technology push' strategy but will need this multi-disciplinary approach and sharing of views and knowledge to develop new strategies and good practice recommendations in the area of 'Broadband for All'. As a co-ordination action the project wants to unite all players active in the field of the end-to-end broadband provisioning for all. It performs a multi-technological analysis of the current and evolving situation, starting from the roadmap information generated by different projects and IST instruments which focus on specific technological domains. The BREAD consortium simultaneously studies the techno-economic, societal and regulatory aspects of this "Broadband for All" concept. It tries to identify the impact of the EU regulatory framework on the successful implementation of new broadband communication services.

Mitigation of image artifacts in LWIR microgrid polarimeter images

NASA Astrophysics Data System (ADS)

Ratliff, Bradley M.; Tyo, J. Scott; Boger, James K.; Black, Wiley T.; Bowers, David M.; Kumar, Rakesh

2007-09-01

Microgrid polarimeters, also known as division of focal plane (DoFP) polarimeters, are composed of an integrated array of micropolarizing elements that immediately precedes the FPA. The result of the DoFP device is that neighboring pixels sense different polarization states. The measurements made at each pixel can be combined to estimate the Stokes vector at every reconstruction point in a scene. DoFP devices have the advantage that they are mechanically rugged and inherently optically aligned. However, they suffer from the severe disadvantage that the neighboring pixels that make up the Stokes vector estimates have different instantaneous fields of view (IFOV). This IFOV error leads to spatial differencing that causes false polarization signatures, especially in regions of the image where the scene changes rapidly in space. Furthermore, when the polarimeter is operating in the LWIR, the FPA has inherent response problems such as nonuniformity and dead pixels that make the false polarization problem that much worse. In this paper, we present methods that use spatial information from the scene to mitigate two of the biggest problems that confront DoFP devices. The first is a polarimetric dead pixel replacement (DPR) scheme, and the second is a reconstruction method that chooses the most appropriate polarimetric interpolation scheme for each particular pixel in the image based on the scene properties. We have found that these two methods can greatly improve both the visual appearance of polarization products as well as the accuracy of the polarization estimates, and can be implemented with minimal computational cost.

Fetal Cortical Transplants in Adult Rats Subjected to Experimental Brain Injury

PubMed Central

Soares, Holly; McIntosh, Tracy K.

1991-01-01

Fetal cortical tissue was injected into injured adult rat brains following concussive fluid percussion (FP) brain injury. Rats subjected to moderate FP injury received E16 cortex transplant injections into lesioned motor cortex 2 days, 1 week, 2 weeks, and 4 weeks post injury. Histological assessment of transplant survival and integration was based upon Nissl staining, glial fibrillary acidic protein (GFAP) immunocytochemistry, and staining for acetylcholinesterase. In addition to histological analysis, the ability of the transplants to attenuate neurological motor deficits associated with concussive FP brain injury was also tested. Three subgroups of rats receiving transplant 1 week, 2 weeks, and 4 weeks post injury Were chosen for evaluation of neurological motor function. Fetal cortical tissue injected into the injury site 4 weeks post injury failed to incorporate with injured host brain, did not affect glial scar formation, and exhibited extensive GFAP immunoreactivity. No improvement in neurological motor function was observed in animals receiving transplants 4 weeks post injury. Conversely, transplants injected 2 days, 1 week, or 2 weeks post injury survived, incorporated with host brain, exhibited little GFAP immunoreactivity, and successfully attenuated glial scarring. However, no significant improvement in motor function was observed at the one week or two week time points. The inability of the transplants to attenuate motor function may indicate inappropriate host/transplant interaction. Our results demonstrate that there exists a temporal window in which fetal cortical transplants can attenuate glial scarring as well as be successfully incorporated into host brains following FP injury. PMID:1782253

Miniature high-resolution guided-wave spectrometer for atmospheric remote sensing

NASA Astrophysics Data System (ADS)

Sloan, James; Kruzelecky, Roman; Wong, Brian; Zou, Jing; Jamroz, Wes; Haddad, Emile; Poirier, Michel

This paper describes the design and application of an innovative spectrometer in which a guided-wave integrated optical spectrometer (IOSPEC) has been coupled with a Fabry-Perot (FP) interferometer. This miniature spectrometer has a net mass under 3 kg, but is capable of broadband operation at spectral resolutions below 0.03 nm full width half maximum (FWHM). The tuneable FP filter provides very high spectral resolution combined with a large input aper-ture. The solid state guided-wave spectrometer is currently configured for a 512-channel array detector, which provides sub-nm coarse resolution. The ultimate resolution is determined by the FP filter, which is tuned across the desired spectral bands, thereby providing a signal-to-noise ratio (SNR) advantage over scanned spectrometer systems of the square root of the number of detector channels. The guided-wave optics provides robust, long-term optical alignment, while minimising the mechanical complexity. The miniaturisation of the FP-IOSPEC spectrometer allows multiple spectrometers to be accommodated on a single MicroSat. Each of these can be optimised for selected measurement tasks and views, thereby enabling more flexible data acquisition strategies with enhanced information content, while minimizing the mission cost. The application of this innovative technology in the proposed Miniature Earth Observation Satellite (MEOS) mission will also be discussed. The MEOS mission, which is designed for the investigation of the carbon and water cycles, relies on multiple IO-SPEC instruments for the simultaneous measurement of a range of atmospheric and surface properties important to climate change.

A healthy turn in urban climate change policies; European city workshop proposes health indicators as policy integrators.

PubMed

Keune, Hans; Ludlow, David; van den Hazel, Peter; Randall, Scott; Bartonova, Alena

2012-06-28

The EU FP6 HENVINET project reviewed the potential relevance of a focus on climate change related health effects for climate change policies at the city region level. This was undertaken by means of a workshop with both scientists, city representatives from several EU-countries, representatives of EU city networks and EU-experts. In this paper we introduce some important health related climate change issues, and discuss the current city policies of the participating cities. The workshop used a backcasting format to analyse the future relevance of a health perspective, and the main benefits and challenges this would bring to urban policy making. It was concluded that health issues have an important function as indicators of success for urban climate change policies, given the extent to which climate change policies contribute to public health and as such to quality of life. Simultaneously the health perspective may function as a policy integrator in that it can combine several related policy objectives, such as environmental policies, health policies, urban planning and economic development policies, in one framework for action. Furthermore, the participants to the workshop considered public health to be of strategic importance in organizing public support for climate change policies. One important conclusion of the workshop was the view that the connection of science and policy at the city level is inadequate, and that the integration of scientific knowledge on climate change related health effects and local policy practice is in need of more attention. In conclusion, the workshop was viewed as a constructive advance in the process of integration which hopefully will lead to ongoing cooperation. The workshop had the ambition to bring together a diversity of actor perspectives for exchange of knowledge and experiences, and joint understanding as a basis for future cooperation. Next to the complementarities in experience and knowledge, the mutual critical reflection was a bonus, as ideas had the opportunity to be scrutinized by others, leading to more robustness and common ground. The structured backcasting approach was helpful in integrating all of this with one common focus, embracing diversity and complexity, and stimulating reflection and new ideas.

A healthy turn in urban climate change policies; European city workshop proposes health indicators as policy integrators

PubMed Central

2012-01-01

Background The EU FP6 HENVINET project reviewed the potential relevance of a focus on climate change related health effects for climate change policies at the city region level. This was undertaken by means of a workshop with both scientists, city representatives from several EU-countries, representatives of EU city networks and EU-experts. In this paper we introduce some important health related climate change issues, and discuss the current city policies of the participating cities. Methods The workshop used a backcasting format to analyse the future relevance of a health perspective, and the main benefits and challenges this would bring to urban policy making. Results It was concluded that health issues have an important function as indicators of success for urban climate change policies, given the extent to which climate change policies contribute to public health and as such to quality of life. Simultaneously the health perspective may function as a policy integrator in that it can combine several related policy objectives, such as environmental policies, health policies, urban planning and economic development policies, in one framework for action. Furthermore, the participants to the workshop considered public health to be of strategic importance in organizing public support for climate change policies. One important conclusion of the workshop was the view that the connection of science and policy at the city level is inadequate, and that the integration of scientific knowledge on climate change related health effects and local policy practice is in need of more attention. In conclusion, the workshop was viewed as a constructive advance in the process of integration which hopefully will lead to ongoing cooperation. Conclusions The workshop had the ambition to bring together a diversity of actor perspectives for exchange of knowledge and experiences, and joint understanding as a basis for future cooperation. Next to the complementarities in experience and knowledge, the mutual critical reflection was a bonus, as ideas had the opportunity to be scrutinized by others, leading to more robustness and common ground. The structured backcasting approach was helpful in integrating all of this with one common focus, embracing diversity and complexity, and stimulating reflection and new ideas. PMID:22759496

Manatee lays groundwork for commercial use of Orimulsion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makansi, J.

1994-09-01

This article describes the conversion of an oil fired plant to Orimulsion described as a fourth fossil fuel, Orimulsion will replace oil at FP and L's Manatee station. The project involves unique business arrangements as well as important combustion, emissions control, and fuel handling system modifications. Florida Power and Light Co (FP and L) spent several years investigating the use of Orimulsion, including a full-scale five-months demonstration at its Sanford Station Unit 4. Now, the utility has taken the next giant leap; it has committed to convert the Manatee station for full-scale use of this unique fuel. The resulting projectmore » breaks new ground in the electric-generating business in several ways, including these: It represents the first long-term commercial contract for use of Orimulsion in the US, and the largest commitment world-wide. It involves unique business arrangements--not the least of which is the second major contract at an electric-utility station for a third-party-owned and operated flue-gas desulfurization (FGD) system. It indicates risk-taking on the part of utilities--with two 800-MW units, Manatee embodies a substantial amount of FP and L's total and incremental capacity base.« less

Estimation of human damage and economic loss of buildings for the worst-credible scenario of tsunami inundation in the city of Augusta, Italy

NASA Astrophysics Data System (ADS)

Pagnoni, Gianluca; Tinti, Stefano

2017-04-01

The city of Augusta is located in the southern part of the eastern coast of Sicily. Italian tsunami catalogue and paleo-tsunami surveys indicate that at least 7 events of tsunami affected the bay of Augusta in the last 4,000 years, two of which are associated with earthquakes (1169 and 1693) that destroyed the city. For these reasons Augusta has been chosen in the project ASTARTE as a test site for the study of issues related to tsunami hazard and risk. In last two years we studied hazard through the approach of the worst-case credible scenario and carried out vulnerability and damage analysis for buildings. In this work, we integrate that research, and estimate the damage to people and the economic loss of buildings due to structural damage. As regards inundation, we assume both uniform inundation levels (bath-tub hypothesis) and inundation data resulting from the worst-case scenario elaborated for the area by Armigliato et al. (2015). Human damage is calculated in three steps using the method introduced by Pagnoni et al. (2016) following the work by Terrier et al. (2012) and by Koshimura et al. (2009). First, we use census data to estimate the number of people present in each residential building affected by inundation; second, based on water column depth and building type, we evaluate the level of damage to people; third, we provide an estimate of fatalities. The economic loss is computed for two types of buildings (residential and trade-industrial) by using data on inundation and data from the real estate market. This study was funded by the EU Project ASTARTE - "Assessment, STrategy And Risk Reduction for Tsunamis in Europe", Grant 603839, 7th FP (ENV.2013.6.4-3)

RST (Robust Satellite Techniques) analysis for monitoring earth emitted radiation in seismically active area of California (US): a long term (2006-2011) analysis of GOES-W/IMAGER thermal data

NASA Astrophysics Data System (ADS)

Tramutoli, V.; Armandi, B.; Filizzola, C.; Genzano, N.; Lisi, M.; Paciello, R.; Pergola, N.

2014-12-01

More than ten years of applications of the RST (Robust Satellite Techniques) methodology for monitoring earthquake prone area by using satellite TIR(Thermal InfraRed) data, have shown the ability of this approach to discern anomalous TIR signals possibly associated to seismic activity from normal fluctuations of Earth's thermal emission related to other causes independent on the earthquake occurrence. The RST approach was already tested in the case of tens of earthquakes occurred in different continents (Europe, Asia, America and Africa), in various geo-tectonic settings (compressive, extensional and transcurrent) and with a wide range of magnitudes (from 4.0 to 7.9), by analyzing time series of TIR images acquired by sensors on board of polar (like NOAA/AVHRR, EOS/MODIS) and geostationary satellites (like MFG/MVIRI, MSG/SEVIRI, GOES/IMAGER). In addition RST method has been independently tested by several researchers around the world as well as in the framework of several projects funded by different national space agencies (like the Italian ASI, the U.S. NASA and the German DLR) and recently during the EC-FP7 projectPRE-EARTHQUAKES (www.pre-earthquakes.org),which was devoted to study the earthquake precursors using satellite techniques. This paper will show the results of RST analysis on 6 years (2006-2011)of TIR satellite record collected by GOES-W/IMAGER over Southern part United State (California).Results will be discussed particularly in the prospective of an integrated approach devoted to systematically collectand analyze in real-time, independent observations for a time-Dependent Assessment of Seismic Hazard (t-DASH).

Pharmacokinetics and pharmacodynamics of GSK961081, a novel inhaled muscarinic antagonist β2 -agonist, and fluticasone propionate administered alone, concurrently and as a combination blend formulation in healthy volunteers.

PubMed

Norris, Virginia; Ambery, Claire; Riley, Trevor

2014-07-01

To investigate the pharmacokinetics and pharmacodynamics of inhaled GSK961081 and fluticasone propionate (FP) given alone, concurrently and as a combination blend formulation. The study was double-blind, double-dummy, four-way crossover. Twenty-four healthy volunteers took single doses of the following in randomized order: (1) GSK961081 800 µg; (2) FP 500 µg; (3) GSK961081 800 µg and FP 500 µg as a blend formulation; and (4) GSK961081 800 µg and FP 500 µg concurrently via separate inhalers. The eLung breathing simulator was also used for the in vitro characterization of the formulations. There was no pharmacokinetic interaction when GSK961081 and FP were administered concurrently. Mean Cmax and AUC(0-t) of GSK961081 were lower (∼20%) and mean Cmax and AUC(0-t) of FP were higher (two fold) following GSK961081/FP blend formulation compared to concurrent or the individual components alone. There was an increase in the FP in vitro ex-throat dose for the GSK961081/FP blend from the eLung breathing simulator. Serum cortisol suppression was greater with GSK961081/FP blend, with lower (∼10%) cortisol levels than after GSK961081 + FP concurrent or FP alone. GSK961081/FP blend formulation was associated with an increase in FP systemic exposure and greater serum cortisol suppression. © 2014, The American College of Clinical Pharmacology.

EU-FP7-iMARS: analysis of Mars multi-resolution images using auto-coregistration, data mining and crowd source techniques

NASA Astrophysics Data System (ADS)

Ivanov, Anton; Muller, Jan-Peter; Tao, Yu; Kim, Jung-Rack; Gwinner, Klaus; Van Gasselt, Stephan; Morley, Jeremy; Houghton, Robert; Bamford, Steven; Sidiropoulos, Panagiotis; Fanara, Lida; Waenlish, Marita; Walter, Sebastian; Steinkert, Ralf; Schreiner, Bjorn; Cantini, Federico; Wardlaw, Jessica; Sprinks, James; Giordano, Michele; Marsh, Stuart

2016-07-01

Understanding planetary atmosphere-surface and extra-terrestrial-surface formation processes within our Solar System is one of the fundamental goals of planetary science research. There has been a revolution in planetary surface observations over the last 15 years, especially in 3D imaging of surface shape. This has led to the ability to be able to overlay different epochs back in time to the mid 1970s, to examine time-varying changes, such as the recent discovery of mass movement, tracking inter-year seasonal changes and looking for occurrences of fresh craters. Within the EU FP-7 iMars project, UCL have developed a fully automated multi-resolution DTM processing chain, called the Co-registration ASP-Gotcha Optimised (CASP-GO), based on the open source NASA Ames Stereo Pipeline (ASP), which is being applied to the production of planetwide DTMs and ORIs (OrthoRectified Images) from CTX and HiRISE. Alongside the production of individual strip CTX & HiRISE DTMs & ORIs, DLR have processed HRSC mosaics of ORIs and DTMs for complete areas in a consistent manner using photogrammetric bundle block adjustment techniques. A novel automated co-registration and orthorectification chain has been developed and is being applied to level-1 EDR images taken by the 4 NASA orbital cameras since 1976 using the HRSC map products (both mosaics and orbital strips) as a map-base. The project has also included Mars Radar profiles from Mars Express and Mars Reconnaissance Orbiter missions. A webGIS has been developed for displaying this time sequence of imagery and a demonstration will be shown applied to one of the map-sheets. Automated quality control techniques are applied to screen for suitable images and these are extended to detect temporal changes in features on the surface such as mass movements, streaks, spiders, impact craters, CO2 geysers and Swiss Cheese terrain. These data mining techniques are then being employed within a citizen science project within the Zooniverse family to verify the results of these data mining techniques. Examples of data mining and its verification will be presented. We will present a software tool to ease access to co-registered MARSIS and SHARAD radargrams and geometry data such as probing point latitude and longitude and spacecraft altitude. Data are extracted from official ESA and NASA released data using self-developed python classes. Geometrical data and metadata are exposed as WFS layers using a QGIS server, which can be further integrated with other data. Radar geometry data will be available as a part of the iMars WebGIS framework and images will be available via PDS and PSA archives. Acknowledgements The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under iMars grant agreement n˚ 607379 as well as partial funding from the STFC "MSSL Consolidated Grant" ST/K000977/1.

Participation and successful patient recruitment in primary care.

PubMed

de Wit, N J; Quartero, A O; Zuithoff, A P; Numans, M E

2001-11-01

The demand for family physicians (FPs) to participate in research is growing. The delicate balance between research participation and the daily practice routine might explain the often-disappointing number of patients recruited. We analyzed practice and physician characteristics associated with successful patient recruitment. We used a survey to conduct this study. There was a total of 165 FPs who participated in a combined randomized clinical trial/cohort study on drug treatment of dyspepsia in the Netherlands. We surveyed FPs about personal and practice characteristics and their motivation for participation in the project. These data were then related to the number of patients recruited. Univariate associations were calculated; relevant factors were entered into a logistic model that predicted patient recruitment. Data on 128 FPs could be analyzed (80% response rate); these FPs recruited 793 patients in the cohort study (mean = 6.3 per FP) and 527 in the clinical trial (mean = 4.2 per FP). The main reasons for participation were the research topic (59%) and the participation of an academic research group in the study (63%). Many FPs felt that participation was a professional obligation (39%); the financial incentive played a minor role (15%). The number of recruited patients was only independently associated with the participation of an academic research group. Successful patient recruitment in primary care research is determined more by motivation driven by the research group than by financial incentives, the research topic, or research experience.

Imaging Redox State in Mouse Muscles of Different Ages.

PubMed

Moon, Lily; Frederick, David W; Baur, Joseph A; Li, Lin Z

2017-01-01

Aging is the greatest risk factor for many diseases. Intracellular concentrations of nicotinamide adenine dinucleotide (NAD + ) and the NAD + -coupled redox state have been proposed to moderate many aging-related processes, yet the specific mechanisms remain unclear. The concentration of NAD + falls with age in skeletal muscle, yet there is no consensus on whether aging will increase or decrease the redox potential of NAD + /NADH. Oxidized flavin groups (Fp) (e.g. FAD, i.e., flavin adenine dinucleotide, contained in flavoproteins) and NADH are intrinsic fluorescent indicators of oxidation and reduction status of tissue, respectively. The redox ratio, i.e., the ratio of Fp to NADH, may be a surrogate indicator of the NAD + /NADH redox potential. In this study we used the Chance redox scanner (NADH/Fp fluorescence imaging at low temperature) to investigate the effect of aging on the redox state of mitochondria in skeletal muscles. The results showed that there are borderline significant differences in nominal concentrations of Fp and NADH, but not in the redox ratio s when comparing 3.5-month and 13-month old muscles of mice (n = 6). It may be necessary to increase the number of muscle samples and study mice of more advanced age.

Cost-Effectiveness Analysis of Family Planning Services Offered by Mobile Clinics versus Static Clinics in Assiut, Egypt.

PubMed

Al-Attar, Ghada S T; Bishai, David; El-Gibaly, Omaima

2017-03-01

Cost effectiveness studies of family planning (FP) services are very valuable in providing evidence-based data for decision makers in Egypt. Cost data came from record reviews for all 15 mobile clinics and a matched set of 15 static clinics and interviews with staff members of the selected clinics at Assiut Governorate. Effectiveness measures included couple years of protection (CYPs) and FP visits. Incremental cost-effectiveness ratios (ICER) and sensitivity analyses were calculated. Mobile clinics cost more per facility, produced more CYPs but had fewer FP visits. Sensitivity analysis was done using: total costs, CYP and FP visits of mobile and static clinics and showed that variations in CYP of mobile and static clinics altered the ICER for CYP from $2 -$6. Mobile clinics with their high emphasis on IUDs offer a reasonable cost effectiveness of $4.46 per additional CYP compared to static clinics. The ability of mobile clinics to reach more vulnerable women and to offer more long acting methods might affect a policy decision between these options. Static clinics should consider whether emphasizing IUDs may make their services more cost-effective.

Vanilla mosaic virus isolates from French Polynesia and the Cook Islands are Dasheen mosaic virus strains that exclusively infect vanilla.

PubMed

Farreyrol, K; Pearson, M N; Grisoni, M; Cohen, D; Beck, D

2006-05-01

Sequence was determined for the coat protein (CP) gene and 3' non-translated region (3'NTR) of two vanilla mosaic virus (VanMV) isolates from Vanilla tahitensis, respectively from the Cook Islands (VanMV-CI) and French Polynesia (VanMV-FP). Both viruses displayed distinctive features in the N-terminal region of their CPs; for VanMV-CI, a 16-amino-acid deletion including the aphid transmission-related DAG motif, and for VanMV-FP, a stretch of GTN repeats that putatively belongs to the class of natively unfolded proteins. VanMV-FP CP also has a novel DVG motif in place of the DAG motif, and an uncommon Q//V protease cleavage site. The sequences were compared to a range of Dasheen mosaic virus (DsMV) strains and to potyviruses infecting orchids. Identity was low to DsMV strains across the entire CP coding region and across the 3'NTR, but high across the CP core and the CI-6K2-NIa region. In accordance with current ICTV criteria for species demarcation within the family Potyviridae, VanMV-CI and VanMV-FP are strains of DsMV that exclusively infect vanilla.

A Procedure to Edit Deep-Towed Navigation Data

DTIC Science & Technology

2003-02-28

K &-Ki. yjsFg_XMR R]bFP £ X_Y UW^`w Y[k�jX_w`[\\RTXZ^`Y�d gZP =J�NtI )��XMRTb )" %$�$I�s s... gZP X_ vJ  XZU] RJ�FP f6R]UT[iSR�RTbFPeU]Pg_PS�[\\Y=R�YF[�jXZw/[\\RTXZ^`Yu[\\RT[ a$U]^`V R]bFPy£ X_Yca$UW^`w d gZP � � JML`J o...34,+8E$>/H(. /*0D$;",+8E$>=?.8"I0*/ bFPm¡¢[w`wP1u�d6fcP [UWPlXZY R]bFPld gZP %$ [YFu�[\\U]PmU]P1V^�`Pu�V

MCH promotes family planning.

PubMed

Duan, Y

1992-06-01

Family planning (FP) has been promoted in China through improvements in maternal and child health (MCH) which have affected people's attitude toward childbearing. A case study of FP in Taicang County of Jiangsu Province, China is given. Total population is 446,620; natural increase is 10/1000. 99% of births have been planned in recent years. Contraceptive prevalence has reached 92.71%. Contraceptive awareness has opened people up to health education in general. The community participates in management of human wastes, improvement of water supplies, and parasite control in rural areas. MCH was begun in the early 1980s with premarital examinations, prenatal examinations, postnatal visits, and physical checkups. A systematic program has established in 1983. A pilot program integrating FP, MCH, and parasite control operated between 1984 and 1986, in 7 townships was established and MCH was institutionalized. Increases occurred in comprehensive care for women from 49.1% in 1984 to 78.3% in 1986. Children's coverage rose from 78.2% to 85.9%. Perinatal mortality dropped from 30.2/1000 to 20.8/1000. Neonatal mortality declined from 21.3/1000 to 17.3/1000. Infant mortality also decreased from 31.6/1000 to 21.5/1000. Integration of programs throughout the county was achieved after 1987. 99% of women used the MCH handbook. Between 1987 and 1990, the perinatal, neonatal, and infant mortality rate dropped to 12.9/1000, 9.5/1000, and 14.7/1000, respectively. MCH achievements are attributed to a strengthening of the MCH network to improve access and improve MCH workers' level of professional skill, to the availability of premarriage and couples of reproductive age services and child care, and to the contribution of research. Careful monitoring during pregnancy helped reduce the incidence of difficult labors for high risk women from 17.55 in 1984 to 11-15% in recent years. 99.9% deliver in hospitals. There were no maternal deaths in 1989 or 1990. Neonatal tetanus has been eliminated. 94.2% of mothers receive postpartum visits. Special services at township hospitals are given to children deemed to be physically weak; 345 in 1990 were so treated. In villages, doctors monitor height and weight of children. 94.7% of children 0-1 year receive comprehensive care. Those 1-7 years also receive a high level of care. Security was enhanced by the MCH measures. Girls and boys are considered equal in good health.

Multi-Element Integrated Project Planning at Kennedy Space Center

NASA Technical Reports Server (NTRS)

Mullon, Robert

2008-01-01

This presentation demonstrates how the ASRC Scheduling team developed working practices to support multiple NASA and ASRC Project Managers using the enterprise capabilities of Primavera P6 and P6 Web Access. This work has proceeded as part of Kennedy Ground Systems' preparation for its transition from the Shuttle Program to the Constellation Program. The presenters will cover Primavera's enterprise-class capabilities for schedule development, integrated critical path analysis, and reporting, as well as advanced Primavera P6 Web Access tools and techniques for communicating project status.

NBS for Drought risks reduction in the Algarve (Portugal): selected achievements from PT FCT ProWaterMan and from EU FP7 MARSOL projects

NASA Astrophysics Data System (ADS)

Lobo-Ferreira, João-Paulo

2017-04-01

Southern Europe and the Mediterranean region are facing the challenge of managing its water resources under conditions of increasing scarcity and/or floods, besides concerns about water quality. Innovative water management strategies with nature-based solutions, such as the storage of excess water during floods, in Managed Aquifer Recharge (MAR) schemes can greatly decrease the risk of floods while it increases water availability for future use, eventually in drought periods. The Algarve region is the southern most region of Portugal mainland. It has an area of 4,997 km2 and about 451 thousand permanent inhabitants. Selected achievements of two research projects (Portugal FCT sponsored ProWaterMan project and EU FP7 sponsored MARSOL project), will be addressed regarding the Campina de Faro and Querença-Silves aquifers in the Algarve. In Faro, the idea of harvesting rainwater from the greenhouse rooftops and using this water to recharge aquifers is not new. However, using this NbS as a climate mitigation and adaptation tool with the overall impact and wide range of benefits is a step forward in innovative methodologies. This NbS can have particular positive impacts in Mediterranean conditions with (new) precipitation patterns, more intense but less frequent. The potential greenhouses surface area of about 2.74 km2 can be used by connecting these infrastructures to several large wells aiming to infiltrate an amount of 1.63 hm3/year of harvested water. There is a strong support from the Portuguese Water Agency (Agência Portuguesa do Ambiente, I.P., Algarve branch), the Water Supplier and Wastewater (Águas do Algarve, S.A.), and the local farmers and land owners which have frequent flood and/or drought problems, represented by HUBEL (a SME that produces most greenhouses for Faro area) in this project. During EU 7FP INO-DEMO MARSOL project, a survey about protection and preservation of groundwater was conducted with a sample of Portuguese farmers of the Algarve region. It included the evaluation of willingness of farmers to collaborate and pay for the use of Managed Aquifer Recharge (MAR) as a nature-based solution to minimize the drought impacts and to manage flood risk in the area. Close cooperation has been established between EIP Water Action Group MARsolutions and FP7 MARSOL INNO_DEMO (http://www.eip-water.eu/close-cooperation-between-eip-marsolutions-and-fp7-marsol-inno-demo-project ). In http://www.eip-water.eu/sites/default/files/Rel%20101_15.pdf a LNEC report is available, presenting a descriptive analysis of the responses to a survey about protection and preservation of groundwater conducted with a sample of Portuguese farmers of the Algarve region. It is possible that Direção Regional de Agricultura e Pescas do Algarve is willing to participate on the implementation the nature-based solutions as they will decrease the risk for agriculture losses. The Portuguese Water Agency has precipitation and flow bulletins for the Algarve, e.g. for Faro and Albufeira areas, in http://snirh.pt/index.php?idMain=1&idItem=1.1 . Concerning the climate change impact in Querença-Silves (QS) Aquifer, LNEC/University of Algarve MARSOL project teams presented descriptions regarding respectively groundwater recharge and flow simulations of future scenarios. E.g. Stigter et al. (2009, 2014) summarized achieved conclusions were "(1) (2020-2050) changes in recharge, particularly due to a reduction in autumn rainfall resulting in a longer dry period. More frequent droughts are predicted at the QS aquifer; (2) toward the end of the century (2069-2099), results indicate a significant decrease (mean 25 %) in recharge at QS aquifer, with an high decrease in absolute terms (mean 134 mm/year); and, (3) scenario modelling of groundwater flow shows its response to the predicted decreases in recharge and increases in pumping rates, with strongly reduced outflow into the coastal wetlands, whereas changes due to sea level rise are negligible". These results are a useful starting point regarding the role of MAR in aquifer systems, taking into account the future trends of climate change patterns expected in the Mediterranean region.

Nutritional and cognitive status of entry-level primary school children in Zomba, rural Malawi.

PubMed

Nkhoma, Owen W W; Duffy, Maresa E; Davidson, Philip W; Cory-Slechta, Deborah A; McSorley, Emeir M; Strain, J J; O'Brien, Gerard M

2013-05-01

Entry-level Malawian children (n = 226) aged 6-8 years from two public primary schools, one a participant in a national school feeding programme (FP), the other not, were investigated for differences in nutritional and cognitive status. Stunted growth (42%) and underweight (25%) were prevalent, with no significant differences between the schools, although the school attended was a significant predictor of mid-upper arm circumference. Previous attendance at a community-based childcare centre was significantly associated with lower body weight and height. There were no significant differences in memory, reversal learning and attention outcomes between the schools. These findings report no major significant difference in nutrition or cognitive statuses between the schools, and on this basis suggest that both schools were equally in need of FP participation. More inclusive interventions and broadening/review of FP participation criteria are recommended.

Homo- and Hetero-Bimetallic Mu(Eta1-O:Eta1-O’) Formate Complexes (M- OCHO-M’)+PF6-(M,M’=(Eta5-C5H5)(CO)(NO)Re, (Eta5-C5H5)(CO)3W, and (Eta5-C5H5)(CO) 2Fe): Their Synthesis, Solution Lability, and Reactivity Towards Hydride Donors

DTIC Science & Technology

1988-10-03

with the requisite organo- metallic Lewis acid [M-H/Ph"C~]. Analogous heterobimetallic Fl-~formates (FpRe) and (FpW) [Fp=Cp(CO)2Fej also are prepared...to examples of 1 (eq.1). Our goal is to develop this latter route and synthesize homo- and heterobimetallic gem-diolate compounds.l. Once available...homobimetallic (l 1 -0,n1 1 -0’) formate compounds 7 [2: M. W(CO) 3 Cp] and 8 [2: M=Re(CO)(NO)Cp], and the heterobimetallic analogs 9 (2: M2 -W(CO) 3 CP

Imaging of striatal dopamine transporters in rat brain with single pinhole SPECT and co-aligned MRI is highly reproducible.

PubMed

Booij, Jan; de Bruin, Kora; de Win, Maartje M L; Lavini, Cristina; den Heeten, Gerard J; Habraken, Jan B A

2003-08-01

A recently developed pinhole high-resolution SPECT system was used to measure striatal to non-specific binding ratios in rats (n = 9), after injection of the dopamine transporter ligand (123)I-FP-CIT, and to assess its test/retest reproducibility. For co-alignment purposes, the rat brain was imaged on a 1.5 Tesla clinical MRI scanner using a specially developed surface coil. The SPECT images showed clear striatal uptake. On the MR images, cerebral and extra-cerebral structures could be easily delineated. The mean striatal to non-specific [(123)I]FP-CIT binding ratios of the test/retest studies were 1.7 +/- 0.2 and 1.6 +/- 0.2, respectively. The test/retest variability was approximately 9%. We conclude that the assessment of striatal [(123)I]FP-CIT binding ratios in rats is highly reproducible.

Distance measurement using frequency scanning interferometry with mode-hoped laser

NASA Astrophysics Data System (ADS)

Medhat, M.; Sobee, M.; Hussein, H. M.; Terra, O.

2016-06-01

In this paper, frequency scanning interferometry is implemented to measure distances up to 5 m absolutely. The setup consists of a Michelson interferometer, an external cavity tunable diode laser, and an ultra-low expansion (ULE) Fabry-Pérot (FP) cavity to measure the frequency scanning range. The distance is measured by acquiring simultaneously the interference fringes from, the Michelson and the FP interferometers, while scanning the laser frequency. An online fringe processing technique is developed to calculate the distance from the fringe ratio while removing the parts result from the laser mode-hops without significantly affecting the measurement accuracy. This fringe processing method enables accurate distance measurements up to 5 m with measurements repeatability ±3.9×10-6 L. An accurate translation stage is used to find the FP cavity free-spectral-range and therefore allow accurate measurement. Finally, the setup is applied for the short distance calibration of a laser distance meter (LDM).

Metabolic Networks Integrative Cardiac Health Project (ICHP) - Center of Excellence

DTIC Science & Technology

2016-04-01

2.6; P = 0.001) among all variables, as the most significant predictor of abnormal CIMT, thus increasing risk for CVD. Conclusions: The Integrative ...1 Award Number: W81XWH-11-2-0227 TITLE: "Metabolic Networks Integrative Cardiac Health Project (ICHP) - Center of Excellence." PRINCIPAL...April 2016 2. REPORT TYPE ANNUAL 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE "Metabolic Networks Integrative Cardiac Health Project (ICHP

Family planning, abortion, and HIV in Ghanaian print media: a 15-month content analysis of a national Ghanaian newspaper.

PubMed

Laar, Amos K

2010-12-01

This study assessed coverage of reproductive health (RH) issues--family planning (FP), abortion, and HIV--in the Ghanaian Daily Graphic newspaper. Using the composite week sampling technique, the researcher analyzed the contents of 62 editions of the paper. Prominence was measured using various attributes, and differences in mean coverage over time were assessed using analysis of variance. This review shows that coverage of RH issues was extraordinarily poor, less than 1 percent each for FP, abortion, and HIV. RH news that was covered was given little prominence. These findings support the popular impression that the Daily Graphic does not give priority to reproductive health issues in its coverage. RH advocates need to develop innovative means of integrating RH content into existing media outlets.

The European Multidisciplinary Seafloor and Water-column Observatory Consortium (EMSO-ERIC): Impact, Progress, and Plans.

NASA Astrophysics Data System (ADS)

Best, Mairi

2016-04-01

EMSO is forging ahead through the next challenge in Earth-Ocean Science: How to co-ordinate ocean data acquisition, analysis and response across provincial, national, regional, and global scales. EMSO provides power, communications, sensors, and data infrastructure for continuous, high resolution, (near)-real-time, interactive ocean observations across a truly multi- and interdisciplinary range of research areas including biology, geology, chemistry, physics, engineering, and computer science; from polar to tropical environments, through the water column down to the abyss. 11 deep sea and 4 shallow nodes span from Arctic through the Atlantic and Mediterranean, to the Black Sea. The EMSO Preparatory Phase (FP7) project led to the Interim phase (involving 13 countries) of forming the legal entity: the EMSO European Research Infrastructure Consortium (EMSO-ERIC). The open user community is through ESONET-Vi (European Seafloor Observatory NETwork - The Vision), following on the extensive scientific community planning contributions of the ESONET-NoE (FP6) project. The further progress made through the FixO3 project (FP7) will also benefit the development of this shared infrastructure. Coordination among nodes is being strengthened through the EMSOdev project (H2020) which will produce the EMSO Generic Instrument Module (EGIM) - standardised observations of temperature, pressure, salinity, dissolved oxygen, turbidity, chlorophyll fluorescence, currents, passive acoustics, pH, pCO2, and nutrients. Early installations are now being upgraded; for example in October 2015 EMSO-France deployed a second cable and junction box serving the Ligurian Sea Node in order to monitor slope stability offshore Nice; in 2016 the EMSO Azores Node will receive a major upgrade that will double its observing capacity; for the Ionian Sea Node the Capo Passero site will be installed and the Catania site will be upgraded. Significant findings are already coming in; for example high frequency surface and subsurface water column measurements the Porcupine Abyssal Plain sustained Observatory (PAP-SO) Node in the northeast Atlantic (49N, 16:5W) show an increase in seawater p(CO2) (from 339 μatm in 2003 to 353 μatm in 2011) with little variability in the mean air-sea CO2 flux. In the Central Eastern Atlantic, the PLOCAN open-ocean Node (a.k.a ESTOC station) has long-standing time-series on surface and water column variables, most notably on water column physical, biogeochemical and acidification processes. Acquired data have contributed to the assessment efforts of the Intergovernmental Panel on Climate Change (IPCC) and the characterization of oceanic processes in the North Atlantic subtropical gyre. EMSO not only brings together countries and disciplines, but allows the pooling of resources and coordination to assemble harmonised data into a comprehensive regional ocean picture which it will then make available to researchers and stakeholders worldwide on an open and interoperable access basis.

Art and human embryonic stem cells: from the bench to the high street.

PubMed

Duprat, Sebastien

2009-03-01

ESTOOLS, a project funded by the European Commission (FP6), gathers expertise on human embryonic stem cells in 10 countries of the European Research Area. The ESTOOLS outreach program uses Art extensively as the only universal cross-cultural and cross-religion means of communication. The Smile of a Stem Cell photo exhibition, a major component of this program, aims to fill a missing link between public dissemination of science and science-illiterate citizens. Scientists are also engaged to stand at a distance from their work and observe it with an outsider's perspective, which enhances their competency to communicate science. The photo exhibition, by its situation upstream of scientific education, makes itself open to interest and enthusiasm among a public with no prerequired scientific knowledge or abilities.

SkWwatch: Introducing European Youth to the World of Scientific Research through Interactive Utilisation of a Global Network of Robotic Telescopes

NASA Astrophysics Data System (ADS)

Sotiriou, M.; Vrazopoulos, H.; Ioannou, P.; Sotiriou, S.; Vagenas, E.

2005-12-01

The SkyWatch project is co-fi nanced by the European Community, within the FP6 framework of Science and Society, The SkyWatch consortium is composed by the following partners: Q-PLAN (GR), EDEN - Open Classroom (UK), Astrophysics Research Institute - Liverpool John Moores University (UK), European Physical Society (FR), Ellinogermaniki Agogi (GR), Stockholm University (SE), SCIENCE PROJECTS (UK) and University of Duisburg-Essen (DE). The aim of the SkyWatch project is to build up the number of youngsters involved in a series of science projects to create a virtual community of prospective young researchers promoting scientifi c culture. The project will allow young people to access and use robotic telescopes remotely in real-time, perform observations, analyze data and results and fi nally to develop and suggest solutions to selected research/scientifi c topics, all achieved through an innovative web-based learning environment. The dissemination of the project's activities is also served by a European Science Contest on science topics and projects, a series of popular science distance learning courses (Science Days) for European youth, promotion of concepts and ideas of science of a multidisciplinary nature: astronomy, physics, mathematics, chemistry, etc. The young participants are prompted to organize teams (school classes, groups of students, etc.) and to design, develop and implement projects and activities with the use of robotic telescopes under the guidance and the continuous support of a team of experts.

Exposure to sub-acute doses of fipronil and buprofezin in combination or alone induces biochemical, hematological, histopathological and genotoxic damage in common carp (Cyprinus carpio L.).

PubMed

Qureshi, Irfan Zia; Bibi, Asia; Shahid, Sana; Ghazanfar, Madiha

2016-10-01

Use of pesticides or insecticides can be highly toxic to aquatic life forms due to leaching and agricultural runoff, rains or flood. Fipronil (FP) is a GABA receptor inhibitor, while buprofezin (BPFN) is an insect growth regulator. Presently, we exposed groups of aquaria acclimated carp fish (Cyprinus carpio) for 96h to sub-lethal concentrations of fipronil (400μgL(-1); 9.15×10(-7)molL(-1)) and buprofezin (BPFN, 100mgL(-1); 1.072×10(-6)molL(-1)) singly or in combination. The extent of damage was assessed at biochemical, hematological, molecular biological and histopathological level. Results obtained in treated fish were compared statistically with those of control non-treated fish and also among treatment groups. Significance level was p<0.05. Compared to control, serum total protein and globulin concentrations decreased significantly (p<0.0001) in fish treated with FP; while albumin concentration remained unaltered with all treatments. Glucose concentration decreased significantly (p<0.002) in fish treated with FP. In contrast, combined FP+BPFN treatment and BPFN treatment caused insignificant elevation of glucose concentration. Hematological assessment demonstrated significant decrease in red blood cell and thrombocyte counts, hemoglobin concentration and hematocrit percent; while white blood cell count showed an increase in all treatment groups (p<0.0001). Blood smears from pesticide treated fish revealed aberrant erythrocyte morphologies which included necrosis, micronuclear formation and hyperchromatosis. DNA laddering assay carried out on whole blood demonstrated excessive smear formation in combined FP+BPFN and BPFN treatment groups but no smear formation was noticeable in FP treated fish. Compared to control, whole blood DNA content increased significantly in the combined FP+BPFN and BPFN treatment groups (p<0.001 and p<0.009). With all treatments histopathological changes observed in the gills were: epithelial uplifting and necrosis of lamellae, lamellar atrophy, disruption of cartilaginous core, fusion and disorganization of lamellae and telangiectasia. In liver these were: karyorrhexis, hepatocellular hypertrophy, nuclear hypertrophy, melanomacrophage aggregates and central vein contraction, while in the kidney: deterioration of glomerulus and dilatation of Bowman's space, dilatation of renal tubules, thyroidisation, altered tubular lumen, nuclear hypertrophy, cellular atrophy, and cellular necrosis were the outcome. Our study revealed that FP and BPFN produce highly toxic effects on fish when given in combination or singly. To our knowledge, this is the first report on toxicity caused by FP and BPFN in single and combined state. Copyright © 2016 Elsevier B.V. All rights reserved.

Greater involvement of HIV-infected peer-mothers in provision of reproductive health services as "family planning champions" increases referrals and uptake of family planning among HIV-infected mothers.

PubMed

Mudiope, Peter; Musingye, Ezra; Makumbi, Carolyne Onyango; Bagenda, Danstan; Homsy, Jaco; Nakitende, Mai; Mubiru, Mike; Mosha, Linda Barlow; Kagawa, Mike; Namukwaya, Zikulah; Fowler, Mary Glenn

2017-06-27

In 2012, Makerere University Johns - Hopkins University, and Mulago National Referral Hospital, with support from the National Institute of Health (under Grant number: NOT AI-01-023) undertook operational research at Mulago National Hospital PMTCT/PNC clinics. The study employed Peer Family Planning Champions to offer health education, counselling, and triage aimed at increasing the identification, referral and family planning (FP) uptake among HIV positive mothers attending the clinic. The Peer Champion Intervention to improve FP uptake was introduced into Mulago Hospital PMTCT/PNC clinic, Kampala Uganda. During the intervention period, peers provided additional FP counselling and education; assisted in identification and referral of HIV Positive mothers in need of FP services; and accompanied referred mothers to FP clinics. We compiled and compared the average proportions of mothers in need that were referred and took up FP in the pre-intervention (3 months), intervention (6 months), and post-intervention(3 months) periods using interrupted time series with segmented regression models with an autoregressive term of one. Overall, during the intervention, the proportion of referred mothers in need of FP increased by 30.4 percentage points (P < 0.001), from 52.7 to 83.2 percentage points. FP uptake among mothers in need increased by over 31 percentage points (P < 0.001) from 47.2 to 78.5 percentage points during the intervention. There was a positive non-significant change in the weekly trend of referral β 3  = 2.9 percentage points (P = 0.077) and uptake β 3  = 1.9 percentage points (P = 0.176) during the intervention as compared to the pre-intervention but this was reversed during the post intervention. Over 57% (2494) mothers took up Depo-Provera injectable-FP method during the study. To support overstrained health care work force in post-natal clinics, peers in trained effective family planning can be a valuable addition to clinic staff in limited-resource settings. The study provides additional evidence on the utilization of peer mothers in HIV care, improves health services uptake including family planning which is a common practice in many donor supported programs. It also provides evidence that may be used to advocate for policy revisions in low-income countries to include peers as support staff especially in busy clinic settings with poor services uptake.

Retrospective Comparison of Fluticasone Propionate and Oral Viscous Budesonide in Children With Eosinophilic Esophagitis.

PubMed

Fable, Jacqueline M; Fernandez, Marina; Goodine, Susan; Lerer, Trudy; Sayej, Wael N

2018-01-01

Eosinophilic esophagitis (EoE) is treated with dietary modification and/or pharmacologic management with swallowed topical steroids. Swallowed fluticasone propionate (FP) and oral viscous budesonide (OVB) have proven to be effective in resolving symptoms and reversing histologic changes in children and adults with EoE. There are minimal comparative studies between the 2 agents. The aim of the study was to retrospectively compare endoscopic and histologic outcomes after FP versus OVB therapy in children with EoE in our center. We performed a retrospective chart review of subjects diagnosed with EoE at a tertiary care center between 2010 and 2015. Inclusion criteria were FP or OVB therapy for ≥8 weeks along with pre- and post-treatment endoscopic evaluation. Demographic and clinical features and endoscopic and histologic assessment were recorded for comparative analysis. Histologic response was defined as <15 eos/hpf and remission as <5 eos/hpf. The study included 68 EoE patients (20 FP and 48 OVB) with a mean age of 10.6 ± 5.2 years (range 1-20 years); 81% were boys and 68% were Caucasian. No significant demographic or clinical differences were noted between the 2 study groups. Overall histologic response to topical steroids was seen in 44 of 68 (65%) patients. A significantly greater number of patients achieved histologic response with OVB (36/48, 75%) than with FP (8/20, 40%) (P = 0.0059). Mean pretreatment peak eos/hpf was 46 ± 19 in the FP group versus 45 ± 23 in the OVB group. Mean post-treatment peak eos/hpf was 20 ± 29 in the FP group versus 12 ± 16 in the OVB group (P = 0.002). There was also a significantly greater difference in the change of absolute eos/hpf from pre- to post-treatment in the OVB group (-33) versus FP (18) (P = 0.047). A greater number of OVB-treated patients without asthma had a histologic response compared to those with asthma (P = 0.031). The response to OVB was not affected by the delivery vehicle, namely sucralose (Splenda) versus Neocate Duocal. Our data suggest that treatment with OVB leads to better endoscopic and histologic outcomes than FP. Adherence to treatment and history of asthma are major determining factors in the response to treatments. Using Neocate Duocal as the OVB delivery vehicle is just as effective as sucralose.

ASASSN-16fp (SN 2016coi): a transitional supernova between Type Ic and broad-lined Ic

NASA Astrophysics Data System (ADS)

Kumar, Brajesh; Singh, A.; Srivastav, S.; Sahu, D. K.; Anupama, G. C.

2018-01-01

We present results based on a well-sampled optical (UBVRI) and ultraviolet (Swift/UVOT) imaging, and low-resolution optical spectroscopic follow-up observations of the nearby Type Ic supernova (SN) ASASSN-16fp (SN 2016coi). The SN was monitored during the photospheric phase (-10 to +33 d with respect to the B-band maximum light). The rise to maximum light and early post-maximum decline of the light curves are slow. The peak absolute magnitude (MV = -17.7 ± 0.2 mag) of ASASSN-16fp is comparable with broad-lined Ic SN 2002ap, SN 2012ap and transitional Ic SN 2004aw but considerably fainter than the gamma-ray burst/X-ray flash associated SNe (e.g. SN 1998bw, 2006aj). Similar to the light curve, the spectral evolution is also slow. ASASSN-16fp shows distinct photospheric phase spectral lines along with the C II features. The expansion velocity of the ejecta near maximum light reached ∼16 000 km s-1 and settled to ∼8000 km s-1, ∼1 month post-maximum. Analytical modelling of the quasi-bolometric light curve of ASASSN-16fp suggests that ∼0.1 M⊙ 56Ni mass was synthesized in the explosion, with a kinetic energy of 6.9^{+1.5}_{-1.3} × 1051 erg and total ejected mass of ∼4.5 ± 0.3 M⊙.

Teaching Chemistry about "Stevia"--A Case of Cooperative Curriculum Innovation within PROFILES in Germany

ERIC Educational Resources Information Center

Stuckey, Marc; Lippel, Marianne; Eilks, Ingo

2014-01-01

PROFILES is a project of teacher education and curriculum innovation funded by the FP7-programme of the European Union. The aim of PROFILES is implementing innovative science teaching practices incorporating a societal perspective and compassing inquiry-based science learning. The University of Bremen, Germany, as one of the partners, combines…

Comparison of rapid descriptive sensory methodologies: Free-Choice Profiling, Flash Profile and modified Flash Profile.

PubMed

Liu, Jing; Bredie, Wender L P; Sherman, Emma; Harbertson, James F; Heymann, Hildegarde

2018-04-01

Rapid sensory methods have been developed as alternatives to traditional sensory descriptive analysis methods. Among them, Free-Choice Profiling (FCP) and Flash Profile (FP) are two that have been known for many years. The objectives of this work were to compare the rating-based FCP and ranking-based FP method; to evaluate the impact of adding adjustments to FP approach; to investigate the influence of the number of assessors on the outcome of modified FP. To achieve these aims, a conventional descriptive analysis (DA), FCP, FP and a modified version of FP were carried out. Red wines made by different grape maturity and ethanol concentration were used for sensory testing. This study showed that DA provided a more detailed and accurate information on products through a quantitative measure of the intensity of sensory attributes than FCP and FP. However, the panel hours for conducting DA were higher than that for rapid methods, and FP was even able to separate the samples to a higher degree than DA. When comparing FCP and FP, this study showed that the ranking-based FP provided a clearer separation of samples than rating-based FCP, but the latter was an easier task for most assessors. When restricting assessors on their use of attributes in FP, the sample space became clearer and the ranking task was simplified. The FP protocol with restricted attribute sets seems to be a promising approach for efficient screening of sensory properties in wine. When increasing the number of assessors from 10 to 20 for conducting the modified FP, the outcome tended to be slightly more stable, however, one should consider the degree of panel training when deciding the optimal number of assessors for conducting FP. Copyright © 2018 Elsevier Ltd. All rights reserved.

Compensatory expressive behavior for facial paralysis: adaptation to congenital or acquired disability.

PubMed

Bogart, Kathleen R; Tickle-Degnen, Linda; Ambady, Nalini

2012-02-01

Although there has been little research on the adaptive behavior of people with congenital compared to acquired disability, there is reason to predict that people with congenital conditions may be better adapted because they have lived with their conditions for their entire lives (Smart, 2008). We examined whether people with congenital facial paralysis (FP), compared to people with acquired FP, compensate more for impoverished facial expression by using alternative channels of expression (i.e., voice and body). Participants with congenital (n = 13) and acquired (n = 14) FP were videotaped while recalling emotional events. Expressive verbal behavior was measured using the Linguistic Inquiry Word Count (Pennebaker, Booth, & Francis, 2007). Nonverbal behavior and FP severity were rated by trained coders. People with congenital FP, compared to acquired FP, used more compensatory expressive verbal and nonverbal behavior in their language, voices, and bodies. The extent of FP severity had little effect on compensatory expressivity. This study provides the first behavioral evidence that people with congenital FP use more adaptations to express themselves than people with acquired FP. These behaviors could inform social functioning interventions for people with FP.

Bacteremia in free-ranging Hawaiian green turtles, Chelonia mydas, with fibropapillomatosis

USGS Publications Warehouse

Work, Thierry M.; Balazs, G.H.; Wolcott, M.; Morris, Robert

2003-01-01

Past studies of free-ranging green turtles Chelonia mydas with fibropapillomatosis (FP) in Hawaii have shown that animals become immunosuppressed with increasing severity of this disease. Additionally, preliminary clinical examination of moribund turtles with FP revealed that some animals were also bacteraemic. We tested the hypothesis that bacteraemia in sea turtles is associated with the severity of FP. We captured free-ranging green turtles from areas in Hawaii where FP is absent, and areas where FP has been endemic since the late 1950s. Each turtle was given an FP severity score ranging from 0 (no tumours) to 3 (severely affected). A fifth category included turtles that were stranded ashore and moribund with FP. We found that the percentage of turtles with bacteraemia increased with the severity of FP, and that the majority of bacteria cultured were Vibrio spp. Turtles with severe FP were more susceptible to bactaeremia, probably in part due to immunosuppression. The pattern of bacteraemia in relation to severity of disease strengthens the hypothesis that immunosuppression is a sequel to FP.

PanFP: pangenome-based functional profiles for microbial communities.

PubMed

Jun, Se-Ran; Robeson, Michael S; Hauser, Loren J; Schadt, Christopher W; Gorin, Andrey A

2015-09-26

For decades there has been increasing interest in understanding the relationships between microbial communities and ecosystem functions. Current DNA sequencing technologies allows for the exploration of microbial communities in two principle ways: targeted rRNA gene surveys and shotgun metagenomics. For large study designs, it is often still prohibitively expensive to sequence metagenomes at both the breadth and depth necessary to statistically capture the true functional diversity of a community. Although rRNA gene surveys provide no direct evidence of function, they do provide a reasonable estimation of microbial diversity, while being a very cost-effective way to screen samples of interest for later shotgun metagenomic analyses. However, there is a great deal of 16S rRNA gene survey data currently available from diverse environments, and thus a need for tools to infer functional composition of environmental samples based on 16S rRNA gene survey data. We present a computational method called pangenome-based functional profiles (PanFP), which infers functional profiles of microbial communities from 16S rRNA gene survey data for Bacteria and Archaea. PanFP is based on pangenome reconstruction of a 16S rRNA gene operational taxonomic unit (OTU) from known genes and genomes pooled from the OTU's taxonomic lineage. From this lineage, we derive an OTU functional profile by weighting a pangenome's functional profile with the OTUs abundance observed in a given sample. We validated our method by comparing PanFP to the functional profiles obtained from the direct shotgun metagenomic measurement of 65 diverse communities via Spearman correlation coefficients. These correlations improved with increasing sequencing depth, within the range of 0.8-0.9 for the most deeply sequenced Human Microbiome Project mock community samples. PanFP is very similar in performance to another recently released tool, PICRUSt, for almost all of survey data analysed here. But, our method is unique in that any OTU building method can be used, as opposed to being limited to closed-reference OTU picking strategies against specific reference sequence databases. We developed an automated computational method, which derives an inferred functional profile based on the 16S rRNA gene surveys of microbial communities. The inferred functional profile provides a cost effective way to study complex ecosystems through predicted comparative functional metagenomes and metadata analysis. All PanFP source code and additional documentation are freely available online at GitHub ( https://github.com/srjun/PanFP ).

File Specification for GEOS-5 FP (Forward Processing)

NASA Technical Reports Server (NTRS)

Lucchesi, R.

2013-01-01

The GEOS-5 FP Atmospheric Data Assimilation System (GEOS-5 ADAS) uses an analysis developed jointly with NOAA's National Centers for Environmental Prediction (NCEP), which allows the Global Modeling and Assimilation Office (GMAO) to take advantage of the developments at NCEP and the Joint Center for Satellite Data Assimilation (JCSDA). The GEOS-5 AGCM uses the finite-volume dynamics (Lin, 2004) integrated with various physics packages (e.g, Bacmeister et al., 2006), under the Earth System Modeling Framework (ESMF) including the Catchment Land Surface Model (CLSM) (e.g., Koster et al., 2000). The GSI analysis is a three-dimensional variational (3DVar) analysis applied in grid-point space to facilitate the implementation of anisotropic, inhomogeneous covariances (e.g., Wu et al., 2002; Derber et al., 2003). The GSI implementation for GEOS-5 FP incorporates a set of recursive filters that produce approximately Gaussian smoothing kernels and isotropic correlation functions. The GEOS-5 ADAS is documented in Rienecker et al. (2008). More recent updates to the model are presented in Molod et al. (2011). The GEOS-5 system actively assimilates roughly 2 × 10(exp 6) observations for each analysis, including about 7.5 × 10(exp 5) AIRS radiance data. The input stream is roughly twice this volume, but because of the large volume, the data are thinned commensurate with the analysis grid to reduce the computational burden. Data are also rejected from the analysis through quality control procedures designed to detect, for example, the presence of cloud. To minimize the spurious periodic perturbations of the analysis, GEOS-5 FP uses the Incremental Analysis Update (IAU) technique developed by Bloom et al. (1996). More details of this procedure are given in Appendix A. The assimilation is performed at a horizontal resolution of 0.3125-degree longitude by 0.25- degree latitude and at 72 levels, extending to 0.01 hPa. All products are generated at the native resolution of the horizontal grid. The majority of data products are time-averaged, but four instantaneous products are also available. Hourly data intervals are used for two-dimensional products, while 3-hourly intervals are used for three-dimensional products. These may be on the model's native 72-layer vertical grid or at 42 pressure surfaces extending to 0.1 hPa. This document describes the gridded output files produced by the GMAO near real-time operational FP, using the most recent version of the GEOS-5 assimilation system. Additional details about variables listed in this file specification can be found in a separate document, the GEOS-5 File Specification Variable Definition Glossary. Documentation about the current access methods for products described in this document can be found on the GMAO products page: http://gmao.gsfc.nasa.gov/products/.

File Specification for GEOS-5 FP-IT (Forward Processing for Instrument Teams)

NASA Technical Reports Server (NTRS)

Lucchesi, R.

2013-01-01

The GEOS-5 FP-IT Atmospheric Data Assimilation System (GEOS-5 ADAS) uses an analysis developed jointly with NOAA's National Centers for Environmental Prediction (NCEP), which allows the Global Modeling and Assimilation Office (GMAO) to take advantage of the developments at NCEP and the Joint Center for Satellite Data Assimilation (JCSDA). The GEOS-5 AGCM uses the finite-volume dynamics (Lin, 2004) integrated with various physics packages (e.g, Bacmeister et al., 2006), under the Earth System Modeling Framework (ESMF) including the Catchment Land Surface Model (CLSM) (e.g., Koster et al., 2000). The GSI analysis is a three-dimensional variational (3DVar) analysis applied in grid-point space to facilitate the implementation of anisotropic, inhomogeneous covariances (e.g., Wu et al., 2002; Derber et al., 2003). The GSI implementation for GEOS-5 FP-IT incorporates a set of recursive filters that produce approximately Gaussian smoothing kernels and isotropic correlation functions. The GEOS-5 ADAS is documented in Rienecker et al. (2008). More recent updates to the model are presented in Molod et al. (2011). The GEOS-5 system actively assimilates roughly 2 × 10(exp 6) observations for each analysis, including about 7.5 × 10(exp 5) AIRS radiance data. The input stream is roughly twice this volume, but because of the large volume, the data are thinned commensurate with the analysis grid to reduce the computational burden. Data are also rejected from the analysis through quality control procedures designed to detect, for example, the presence of cloud. To minimize the spurious periodic perturbations of the analysis, GEOS-5 FP-IT uses the Incremental Analysis Update (IAU) technique developed by Bloom et al. (1996). More details of this procedure are given in Appendix A. The analysis is performed at a horizontal resolution of 0.625-degree longitude by 0.5-degree latitude and at 72 levels, extending to 0.01 hPa. All products are generated at the native resolution of the horizontal grid. The majority of data products are time-averaged, but four instantaneous products are also available. Hourly data intervals are used for two-dimensional products, while 3-hourly intervals are used for three-dimensional products. These may be on the model's native 72-layer vertical grid or at 42 pressure surfaces extending to 0.1 hPa. This document describes the gridded output files produced by the GMAO near real-time operational GEOS-5 FP-IT processing in support of the EOS instrument teams. Additional details about variables listed in this file specification can be found in a separate document, the GEOS-5 File Specification Variable Definition Glossary.

How to Apply for and Secure EU Funding for Collaborative IBD Research Projects

PubMed Central

Satsangi, Jack; Kitten, Olivier; Chavez, Marcela; Kalla, Rahul; Prel, Nadege; Meuwis, Marie-Alice; Scott, Stephanie; Bonetti, Illaria; Ventham, Nicholas T.

2016-01-01

The European Union offers opportunities for high-level of funding of collaborative European research. Calls are regularly published: after the end of the FP7 funding programme the new round of Horizon 2020 calls started in 2015. Several topics are relevant to inflammatory bowel disease (IBD) challenges, including chronic disease management, biomarker discovery and new treatments developments. The aim of this Viewpoint article is to describe the new Horizon 2020 instrument and the project submission procedures, and to highlight these through the description of tips and tricks, taking advantage of four examples of successful projects in the field of IBD: the SADEL, IBD-BIOM, IBD Character and BIOCYCLE projects. PMID:26744440

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dutta, P.; Siegel, L.; Pinto, J.

This laboratory has previously demonstrated that imipramine (IM) and amitriptyline (AM), inhibit the conversion of riboflavin to its coenzymic derivatives. Several other laboratories have shown that dietary riboflavin deficiency is protective against malarial infection. In the present investigation, the authors determined whether IM and AM exert antimalarial effects similar to that of riboflavin deficiency, as they have hypothesized. In addition, they evaluated whether these drugs, like other antimalarial agents, increase the hemolytic response to ferriprotoporphyrin IX (FP). The growth of P. falciparum (FCR3) in the absence or presence of these drugs (80 ..mu..M) was measured by incubating parasitized erythrocytes formore » 48 h in RPMI 1640 medium. Parasitemia was determined by counting erythrocyte smears and monitoring (/sup 3/H)hypoxanthine uptake. With no drug, parasitemia was 20.3 +/- 5.3%, whereas in the presence of IM and AM, parasitemia was reduced to 7.3 +/- 0.8% and 13.6 +/- 2.8%, respectively. The uptake of (/sup 3/H)hypoxanthine was reduced to 47 +/- 3.6% and 54 +/- 2.9% of control by IM and AM, respectively. Assays of hemolysis were conducted by incubating 0.5% RBC suspension in NaCl-Tris buffer for 3 h at 37/sup 0/C with variable concentrations of drugs and/or FP (1-7 ..mu..M). Both drugs at 10 to 100 ..mu..M significantly enhanced hemolysis induced by FP. No hemolysis by these drugs was detected in the absence of FP. It is concluded that the tricyclic antidepressants, IM and AM, possess substantial antimalarial properties, thereby supporting the hypothesis that drugs which interfere with riboflavin metabolism should also provide protection against malaria.« less

Matching intermediate-term, multi-angle averages of CIRS FP1+FP3 observations for the He VMR and cloud in Saturn’s atmosphere

NASA Astrophysics Data System (ADS)

Serrano, Joshua; Orton, Glenn S.; Sinclair, James; Fletcher, Leigh N.

2017-01-01

IntroductionSaturn’s atmosphere is a complicated system that is affected by many internal and external variables. To better understand these variables and how they affect Saturn’s atmospheric system we rely on data obtained from spacecraft and Earth based observatories. For this particular study, we used data from Cassini’s Composite Infrared Spectrometer (CIRS) instrument.Currently we do not know the exact amount of helium (He) with respect to molecular hydrogen gas (H2) in Saturn’s atmosphere. This He and H2 volume mixing ratio (VMR) is extremely important in understanding the structure and evolution of Saturn’s atmosphere. The CIRS team was not able to identify reliable matching spectra with data obtained from Focal Plane 1 (FP1) and Focal Plane 3 (FP3) of the CIRS instrument.MethodsAll the data sets we have worked with range from the years 2005-2012. Each year’s data sets were organized into 6 month intervals spanning the months January-June and July-December with data for FP1 and FP3 being completely separate. Each data set is also binned by planetographic latitude.Each data point consists of a spectra wavenumber, radiance value, and an emission angle. The emission angle is then converted to the unit μ, the value of this unit is simply the cosine of the emission angle. Initially all data was binned by year, latitude, and calculated µ value. This data was then plotted as a function of radiance and wavenumber to identify areas of spectral overlap data overlap in corresponding FP1 and FP3 data sets. These data sets were then prepped to be processed by a radiative transfer retrieval algorithm called NEMESIS.ResultsFurther binning of the data sets by looking at abundance of spectra values at certain μ values allows us to increase our confidence that these data sets are populated with enough spectra for NEMESIS to work with. NEMESIS has been operating with assumed He and H2 values derived from results of other studies, this means that narrowing down a more accurate He and H2 VMR will take more time and further data processing.

Effects of diet forage proportion on maintenance energy requirement and the efficiency of metabolizable energy use for lactation by lactating dairy cows.

PubMed

Dong, L F; Ferris, C P; McDowell, D A; Yan, T

2015-12-01

The objective of the present study was to examine the effect of dietary forage proportion (FP) on metabolizable energy (ME) requirement for maintenance (MEm) and the efficiency of ME use for lactation (kl) in lactating dairy cows. Data used were derived from 32 calorimetric chamber experiments undertaken at our institute between 1992 and 2010, including data from 818 Holstein-Friesian cows (HF), 50 Norwegian Red cows, and 62 crossbred cows (Jersey × HF or Norwegian Red × HF). Animals were offered forage-only rations (n=66) or forage and concentrate rations (n=864) with FP ranging from 18 to 100% (dry matter basis). The effect of FP was evaluated by dividing the whole data set into 4 groups according to the FP ranges, categorized as FP <30%, FP=30 to 59%, FP=60 to 99%, and FP=100%. The MEm for individual cows was calculated from heat production minus energy losses from inefficiencies of ME use for lactation, energy retention and pregnancy, and kl was obtained from milk energy output adjusted to zero energy balance (El(0)) divided by ME available for production. Increasing FP significantly reduced ME intake and milk energy output, although the differences between the 2 low FP groups were not significant. However, increasing FP significantly increased the ratio of heat production over ME intake and MEm (MJ/kg(0.75)), with the exception that the increases did not reach significance in heat production/ME intake between FP <30% and FP=30 to 59%, or in MEm between FP=60 to 99% and FP=100%. However, the FP had no significant effect on the kl values, which were similar among the 4 groups of cows. The effect of FP was also evaluated using the linear mixed regression technique relating El(0) to ME intake. The results demonstrated that with a common regression coefficient (slope), the regression constants (intercepts) taken as net energy requirement for maintenance significantly increased with increasing FP. However, the increase between the 2 high FP groups did not research significance. It is concluded that increasing diet FP had no effects on kl but significantly increased maintenance energy requirement (MJ/kg(0.75)). These results indicate that using the current energy feeding systems to ration dairy cows managed under low input systems may underestimate their nutrient requirements, because the majority of feeding systems adopted globally do not differentiate the maintenance energy requirements between low and high forage input systems. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Dr. Haryono Suyono, National Family Planning Coordinating Board, Indonesia.

PubMed

1986-11-01

The goal of the Indonesian family planning program has been to institutionalize both the concept and the norm of a small, happy and prosperous family in a manner that is acceptable to all. To this end, a larger role for the private sector in family planning (FP) has been promoted. While the government program has been very effective in the villages, it was not as effective in the urban areas where there are more diverse populations. Several meetings were held to develop a strategy for FP programs in the urban areas involving both the nongovernment organizations (NGOs) and commercial enterprises. It was agreed that several model programs would be developed through the NGOs with funds coming from both international health organizations and the National Family Planning Coordinating Board. It was hoped that the NGOs would develop into self-sufficient organizations. 1 urban activity that has just started is a specially designed social marketing project aimed at increasing the involvement and commitment of males through a condom distribution scheme. Another promising development is the shifting of the management and implementation of FP programs from the government to the community itself. A primary emphasis is to activate the private sector to expand its role in providing FP information and services. The overall strategy is to create a climate that will make it easier for people to increase their role in family planning service delivery and acceptance through mobilization of resources, funds, facilities and infrastructure so that acceptors will gradually pay for family planning services by themselves according to their needs.

Fertility preservation counselling in Dutch Oncology Practice: Are nurses ready to assist physicians?

PubMed

Krouwel, E M; Nicolai, M P J; van Steijn-van Tol, A Q M J; Putter, H; Osanto, S; Pelger, R C M; Elzevier, H W

2017-11-01

Cancer and its treatments may result in impaired fertility, which could cause long-term distress to cancer survivors. For eligible patients, fertility preservation (FP) is available to secure future reproductive potential. Many physicians, however, feel inhibited about discussing FP. Oncology nurses may serve as an initiator for discussing the subject and provide additional support. Our aim was to investigate their knowledge about FP, the way they apply this, and possible barriers to discussing FP with patients of reproductive age. A questionnaire was administered via mail, Internet and the Dutch Oncology Nursing Congress. Four hundred and twenty-one oncology nurses participated, a third of whom (31.1%) had "sufficient" knowledge of FP. Twenty-eight per cent of participants reported that they "never/hardly ever" discussed FP; 32.2% "almost always/always." FP discussions were more frequently performed by graduate nurses, academic nurses, experienced nurses and nurses with sufficient knowledge. Reasons for not discussing FP were a "lack of knowledge" (25.2%), "poor prognosis" (16.4%) and "lack of time" (10.5%). In conclusion, several obstacles may result in FP not being routinely discussed, specifically a lack of knowledge. Yet nurses feel responsible for addressing the issue, indicating that assistance with FP discussions should be encouraged. Educational training about FP is recommended. © 2016 John Wiley & Sons Ltd.

The Progress of Research Project for Magnetized Target Fusion in China

NASA Astrophysics Data System (ADS)

Yang, Xian-Jun

2015-11-01

The fusion of magnetized plasma called Magnetized Target Fusion (MTF) is a hot research area recently. It may significantly reduce the cost and size. Great progress has been achieved in past decades around the world. Five years ago, China initiated the MTF project and has gotten some progress as follows: 1. Verifying the feasibility of ignition of MTF by means of first principle and MHD simulation; 2. Generating the magnetic field over 1400 Tesla, which can be suppress the heat conduction from charged particles, deposit the energy of alpha particle to promote the ignition process, and produce the stable magnetized plasma for the target of ignition; 3. The imploding facility of FP-1 can put several Mega Joule energy to the solid liner of about ten gram in the range of microsecond risen time, while the simulating tool has been developed for design and analysis of the process; 4. The target of FRC can be generated by ``YG 1 facility'' while some simulating tools have be developed. Next five years, the above theoretical work and the experiments of MTF may be integrated to step up as the National project, which may make my term play an important lead role and be supposed to achieve farther progress in China. Supported by the National Natural Science Foundation of China under Grant No 11175028.

XML-based information system for planetary sciences

NASA Astrophysics Data System (ADS)

Carraro, F.; Fonte, S.; Turrini, D.

2009-04-01

EuroPlaNet (EPN in the following) has been developed by the planetological community under the "Sixth Framework Programme" (FP6 in the following), the European programme devoted to the improvement of the European research efforts through the creation of an internal market for science and technology. The goal of the EPN programme is the creation of a European network aimed to the diffusion of data produced by space missions dedicated to the study of the Solar System. A special place within the EPN programme is that of I.D.I.S. (Integrated and Distributed Information Service). The main goal of IDIS is to offer to the planetary science community a user-friendly access to the data and information produced by the various types of research activities, i.e. Earth-based observations, space observations, modeling, theory and laboratory experiments. During the FP6 programme IDIS development consisted in the creation of a series of thematic nodes, each of them specialized in a specific scientific domain, and a technical coordination node. The four thematic nodes are the Atmosphere node, the Plasma node, the Interiors & Surfaces node and the Small Bodies & Dust node. The main task of the nodes have been the building up of selected scientific cases related with the scientific domain of each node. The second work done by EPN nodes have been the creation of a catalogue of resources related to their main scientific theme. Both these efforts have been used as the basis for the development of the main IDIS goal, i.e. the integrated distributed service. An XML-based data model have been developed to describe resources using meta-data and to store the meta-data within an XML-based database called eXist. A search engine has been then developed in order to allow users to search resources within the database. Users can select the resource type and can insert one or more values or can choose a value among those present in a list, depending on selected resource. The system searches for all the resources containing the inserted values within the resources descriptions. An important facility of the IDIS search system is the multi-node search capability. This is due to the capacity of eXist to make queries on remote databases. This allows the system to show all resources which satisfy the search criteria on local node and to show how many resources are found on remote nodes, giving also a link to open the results page on remote nodes. During FP7 the development of the IDIS system will have the main goal to make the service Virtual Observatory compliant.

Contraceptive use in Indonesia: a history of the programme and the characteristics of users.

PubMed

Samosir, O B

1992-12-01

In Indonesia, President Suharto instituted a population policy in the late 1960s to achieve national development goals. The government also introduced education, health, and economic-oriented development programs. Since then, it has continued to provide political, legal, moral, administrative, and financial support to the national family planning (FP) program. The program was first introduced in the most populous provinces of Java and Bali. It eventually spread to the remaining provinces. It has 3 component programs to achieve national population goals: on extension program (IEC activities and free contraceptives), program maintenance (community-based distribution), and an institutionalization program (integrated programs, population education, and recruiting community leaders). In 1987, the FP Self-Reliance and Blue Circle Campaign programs began to turn FP responsibilities over to communities and individuals. Between 1967 and 1981, the total fertility rate (TFR) fell from 5.61 to 4.06. The greatest fertility declines were in Bali (48.11%) and North Sulawesi (47.2%). An analysis of 1987 National Indonesian Contraceptive Prevalence Survey data shows that the TFR fell from 4.3 to 3.5 (23%) between 1984 and 1987. Between 1980 and 1987, the contraceptive use rate rose from 27 to 48%. Java and Bali had the highest contraceptive user rates. Large family size had a significant positive effect on contraceptive use. Educated women were more likely to use contraceptives than uneducated women, especially in Outer Java-Bali regions. In some regions, the husband's education affected contraceptive use. Muslim women were less likely to use contraceptives than other women in Bali and Outer Java-Bali I. Even though urban women had the highest use rates, the FP program was more successful in rural areas. The success of the national FP program and other development programs accounted for the fertility decline as well as the decline in mortality, resulting in a fall in the population growth rate.

A SOA broker solution for standard discovery and access services: the GI-cat framework

NASA Astrophysics Data System (ADS)

Boldrini, Enrico

2010-05-01

GI-cat ideal users are data providers or service providers within the geoscience community. The former have their data already available through an access service (e.g. an OGC Web Service) and would have it published through a standard catalog service, in a seamless way. The latter would develop a catalog broker and let users query and access different geospatial resources through one or more standard interfaces and Application Profiles (AP) (e.g. OGC CSW ISO AP, CSW ebRIM/EO AP, etc.). GI-cat actually implements a broker components (i.e. a middleware service) which carries out distribution and mediation functionalities among "well-adopted" catalog interfaces and data access protocols. GI-cat also publishes different discovery interfaces: the OGC CSW ISO and ebRIM Application Profiles (the latter coming with support for the EO and CIM extension packages) and two different OpenSearch interfaces developed in order to explore Web 2.0 possibilities. An extended interface is also available to exploit all available GI-cat features, such as interruptible incremental queries and queries feedback. Interoperability tests performed in the context of different projects have also pointed out the importance to enforce compatibility with existing and wide-spread tools of the open source community (e.g. GeoNetwork and Deegree catalogs), which was then achieved. Based on a service-oriented framework of modular components, GI-cat can effectively be customized and tailored to support different deployment scenarios. In addition to the distribution functionality an harvesting approach has been lately experimented, allowing the user to switch between a distributed and a local search giving thus more possibilities to support different deployment scenarios. A configurator tool is available in order to enable an effective high level configuration of the broker service. A specific geobrowser was also naturally developed, for demonstrating the advanced GI-cat functionalities. This client, called GI-go, is an example of the possible applications which may be built on top of the GI-cat broker component. GI-go allows discovering and browsing of the available datasets, retrieving and evaluating their description and performing distributed queries according to any combination of the following criteria: geographic area, temporal interval, topic of interest (free-text and/or keyword selection are allowed) and data source (i.e. where, when, what, who). The results set of a query (e.g. datasets metadata) are then displayed in an incremental way leveraging the asynchronous interactions approach implemented by GI-cat. This feature allows the user to access the intermediate query results. Query interruption and feedback features are also provided to the user. Alternatively, user may perform a browsing task by selecting a catalog resource from the current configuration and navigate through its aggregated and/or leaf datasets. In both cases datasets metadata, expressed according to ISO 19139 (and also Dublin Core and ebRIM if available), are displayed for download, along with a resource portrayal and actual data access (when this is meaningful and possible). The GI-cat distributed catalog service has been successfully deployed and experimented in the framework of different projects and initiative, including the SeaDataNet FP6 project, GEOSS IP3 (Interoperability Process Pilot Project), GEOSS AIP-2 (Architectural Implementation Project - Phase 2), FP7 GENESI-DR, CNR GIIDA, FP7 EUROGEOSS and ESA HMA project.

Revisiting the relationship between environmental and financial performance in Chinese industry.

PubMed

Qi, G Y; Zeng, S X; Shi, Jonathan J; Meng, X H; Lin, H; Yang, Q X

2014-12-01

The debate on the relationship between corporate or industrial environmental performance (EP) and financial performance (FP) has yet to be resolved, and studies need to examine the possible moderating effects on the EP-FP link. We argue that industrial EP has a positive effect on FP and that industrial munificence and resource slack can moderate the EP-FP link. Using a dataset from Chinese industrial firms, we examine the direct effect of industrial EP on FP and the indirect effects of industrial munificence and resource slack on the EP-FP link. Our results show that improving corporate or industrial-level EP significantly influences FP and that slack resources play a significant role on the EP-FP link. However, we found no significant moderating effect of industrial munificence on the link. Copyright © 2014 Elsevier Ltd. All rights reserved.

IMPACT OF FISSION PRODUCTS IMPURITY ON THE PLUTONIUM CONTENT IN PWR MOX FUELS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilles Youinou; Andrea Alfonsi

2012-03-01

This report presents the results of a neutronics analysis done in response to the charter IFCA-SAT-2 entitled 'Fuel impurity physics calculations'. This charter specifies that the separation of the fission products (FP) during the reprocessing of UOX spent nuclear fuel assemblies (UOX SNF) is not perfect and that, consequently, a certain amount of FP goes into the Pu stream used to fabricate PWR MOX fuel assemblies. Only non-gaseous FP have been considered (see the list of 176 isotopes considered in the calculations in Appendix 1). This mixture of Pu and FP is called PuFP. Note that, in this preliminary analysis,more » the FP losses are considered element-independent, i.e., for example, 1% of FP losses mean that 1% of all non-gaseous FP leak into the Pu stream.« less

Combination of CT scanning and fluoroscopy imaging on a flat-panel CT scanner

NASA Astrophysics Data System (ADS)

Grasruck, M.; Gupta, R.; Reichardt, B.; Suess, Ch.; Schmidt, B.; Stierstorfer, K.; Popescu, S.; Brady, T.; Flohr, T.

2006-03-01

We developed and evaluated a prototype flat-panel detector based Volume CT (fpVCT) scanner. The fpVCT scanner consists of a Varian 4030CB a-Si flat-panel detector mounted in a multi slice CT-gantry (Siemens Medical Solutions). It provides a 25 cm field of view with 18 cm z-coverage at the isocenter. In addition to the standard tomographic scanning, fpVCT allows two new scan modes: (1) fluoroscopic imaging from any arbitrary rotation angle, and (2) continuous, time-resolved tomographic scanning of a dynamically changing viewing volume. Fluoroscopic imaging is feasible by modifying the standard CT gantry so that the imaging chain can be oriented along any user-selected rotation angle. Scanning with a stationary gantry, after it has been oriented, is equivalent to a conventional fluoroscopic examination. This scan mode enables combined use of high-resolution tomography and real-time fluoroscopy with a clinically usable field of view in the z direction. The second scan mode allows continuous observation of a timeevolving process such as perfusion. The gantry can be continuously rotated for up to 80 sec, with the rotation time ranging from 3 to 20 sec, to gather projection images of a dynamic process. The projection data, that provides a temporal log of the viewing volume, is then converted into multiple image stacks that capture the temporal evolution of a dynamic process. Studies using phantoms, ex vivo specimens, and live animals have confirmed that these new scanning modes are clinically usable and offer a unique view of the anatomy and physiology that heretofore has not been feasible using static CT scanning. At the current level of image quality and temporal resolution, several clinical applications such a dynamic angiography, tumor enhancement pattern and vascularity studies, organ perfusion, and interventional applications are in reach.

Channels selection using independent component analysis and scalp map projection for EEG-based driver fatigue classification.

PubMed

Rifai Chai; Naik, Ganesh R; Sai Ho Ling; Tran, Yvonne; Craig, Ashley; Nguyen, Hung T

2017-07-01

This paper presents a classification of driver fatigue with electroencephalography (EEG) channels selection analysis. The system employs independent component analysis (ICA) with scalp map back projection to select the dominant of EEG channels. After channel selection, the features of the selected EEG channels were extracted based on power spectral density (PSD), and then classified using a Bayesian neural network. The results of the ICA decomposition with the back-projected scalp map and a threshold showed that the EEG channels can be reduced from 32 channels into 16 dominants channels involved in fatigue assessment as chosen channels, which included AF3, F3, FC1, FC5, T7, CP5, P3, O1, P4, P8, CP6, T8, FC2, F8, AF4, FP2. The result of fatigue vs. alert classification of the selected 16 channels yielded a sensitivity of 76.8%, specificity of 74.3% and an accuracy of 75.5%. Also, the classification results of the selected 16 channels are comparable to those using the original 32 channels. So, the selected 16 channels is preferable for ergonomics improvement of EEG-based fatigue classification system.

Critters: K-6 Life Science Activities. Project AIMS.

ERIC Educational Resources Information Center

Allen, Maureen Murphy; And Others

Project AIMS (Activities to Integrate Mathematics and Science) has as its purpose the integration of subject matter in grades K-9. Field testing of the curriculum materials produced by AIMS indicates that this integration produces the following beneficial results: (1) mathematics becomes more meaningful, hence more useful; (2) science is…

Quantification of the impact of precipitation spatial distribution uncertainty on predictive uncertainty of a snowmelt runoff model

NASA Astrophysics Data System (ADS)

Jacquin, A. P.

2012-04-01

This study is intended to quantify the impact of uncertainty about precipitation spatial distribution on predictive uncertainty of a snowmelt runoff model. This problem is especially relevant in mountain catchments with a sparse precipitation observation network and relative short precipitation records. The model analysed is a conceptual watershed model operating at a monthly time step. The model divides the catchment into five elevation zones, where the fifth zone corresponds to the catchment's glaciers. Precipitation amounts at each elevation zone i are estimated as the product between observed precipitation at a station and a precipitation factor FPi. If other precipitation data are not available, these precipitation factors must be adjusted during the calibration process and are thus seen as parameters of the model. In the case of the fifth zone, glaciers are seen as an inexhaustible source of water that melts when the snow cover is depleted.The catchment case study is Aconcagua River at Chacabuquito, located in the Andean region of Central Chile. The model's predictive uncertainty is measured in terms of the output variance of the mean squared error of the Box-Cox transformed discharge, the relative volumetric error, and the weighted average of snow water equivalent in the elevation zones at the end of the simulation period. Sobol's variance decomposition (SVD) method is used for assessing the impact of precipitation spatial distribution, represented by the precipitation factors FPi, on the models' predictive uncertainty. In the SVD method, the first order effect of a parameter (or group of parameters) indicates the fraction of predictive uncertainty that could be reduced if the true value of this parameter (or group) was known. Similarly, the total effect of a parameter (or group) measures the fraction of predictive uncertainty that would remain if the true value of this parameter (or group) was unknown, but all the remaining model parameters could be fixed. In this study, first order and total effects of the group of precipitation factors FP1- FP4, and the precipitation factor FP5, are calculated separately. First order and total effects of the group FP1- FP4 are much higher than first order and total effects of the factor FP5, which are negligible This situation is due to the fact that the actual value taken by FP5 does not have much influence in the contribution of the glacier zone to the catchment's output discharge, mainly limited by incident solar radiation. In addition to this, first order effects indicate that, in average, nearly 25% of predictive uncertainty could be reduced if the true values of the precipitation factors FPi could be known, but no information was available on the appropriate values for the remaining model parameters. Finally, the total effects of the precipitation factors FP1- FP4 are close to 41% in average, implying that even if the appropriate values for the remaining model parameters could be fixed, predictive uncertainty would be still quite high if the spatial distribution of precipitation remains unknown. Acknowledgements: This research was funded by FONDECYT, Research Project 1110279.

Compensatory Expressive Behavior for Facial Paralysis: Adaptation to Congenital or Acquired Disability

PubMed Central

Bogart, Kathleen R.; Tickle-Degnen, Linda; Ambady, Nalini

2015-01-01

Purpose/Objective Although there has been little research on the adaptive behavior of people with congenital compared to acquired disability, there is reason to predict that people with congenital conditions may be better adapted because they have lived with their conditions for their entire lives (Smart, 2008). We examined whether people with congenital facial paralysis (FP), compared to people with acquired FP, compensate more for impoverished facial expression by using alternative channels of expression (i.e. voice and body). Research Method/Design Participants with congenital (n = 13) and acquired (n = 14) FP were videotaped while recalling emotional events. Main Outcome Measures Expressive verbal behavior was measured using the Linguistic Inquiry Word Count (Pennebaker, Booth & Francis, 2007). Nonverbal behavior and FP severity were rated by trained coders. Results People with congenital FP, compared to acquired FP, used more compensatory expressive verbal and nonverbal behavior in their language, voices, and bodies. The extent of FP severity had little effect on compensatory expressivity. Conclusions/Implications This study provides the first behavioral evidence that people with congenital FP use more adaptations to express themselves than people with acquired FP. These behaviors could inform social functioning interventions for people with FP. PMID:22369116

Actions to Empower Digital Competences in Healthcare Workforce: A Qualitative Approach.

PubMed

Konstantinidis, Stathis Th; Li, Sisi; Traver, Vicente; Zary, Nabil; Bamidis, Panagiotis D

2017-01-01

While healthcare systems are taking advantage of the ICT to improve healthcare services, healthcare workforce needs additional competencies in order to continue the provision of the best achievable care. In this paper emphasis is given to an active research effort taken during the MEI2015 Conference. Based on hands-on group-work, participants identified the actions needed to boost the acquisition of IT competences by healthcare workforce and collaboratively indicated the most important actions. The leading priority actions were integration of IT into Curriculum, continuous IT/eHealth training at the work place, raising awareness of IT competences, participatory decisions for actions, match healthcare applications to users' own context, inclusion of professionals in the development of eHealth projects. Interestingly, the proposed actions coupling the outcomes of another study following a different methodology, but also support the cooperation opportunities on IT skills for healthcare workforce. The latter formed a set of recommendations which were proposed within the CAMEI coordination and support action of EC-FP7.

PRoViScout: a planetary scouting rover demonstrator

NASA Astrophysics Data System (ADS)

Paar, Gerhard; Woods, Mark; Gimkiewicz, Christiane; Labrosse, Frédéric; Medina, Alberto; Tyler, Laurence; Barnes, David P.; Fritz, Gerald; Kapellos, Konstantinos

2012-01-01

Mobile systems exploring Planetary surfaces in future will require more autonomy than today. The EU FP7-SPACE Project ProViScout (2010-2012) establishes the building blocks of such autonomous exploration systems in terms of robotics vision by a decision-based combination of navigation and scientific target selection, and integrates them into a framework ready for and exposed to field demonstration. The PRoViScout on-board system consists of mission management components such as an Executive, a Mars Mission On-Board Planner and Scheduler, a Science Assessment Module, and Navigation & Vision Processing modules. The platform hardware consists of the rover with the sensors and pointing devices. We report on the major building blocks and their functions & interfaces, emphasizing on the computer vision parts such as image acquisition (using a novel zoomed 3D-Time-of-Flight & RGB camera), mapping from 3D-TOF data, panoramic image & stereo reconstruction, hazard and slope maps, visual odometry and the recognition of potential scientifically interesting targets.