77 FR 5252 - Federal Travel Regulation; GSA E-Gov Travel Service (ETS) Transition to E-Gov Travel Service 2...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... Travel Regulation; GSA E-Gov Travel Service (ETS) Transition to E-Gov Travel Service 2 (ETS2) AGENCY... (QMC), at [email protected]gov or (703) 605-2151. SUPPLEMENTARY INFORMATION: The Federal Travel...-GOV TRAVEL SERVICE GSA Bulletin ETS 12-01 TO: Heads of Federal Agencies SUBJECT: GSA E-Gov Travel...

E 3 and M 2 transition strengths in Bi20983

NASA Astrophysics Data System (ADS)

Roberts, O. J.; NiÅ£ǎ, C. R.; Bruce, A. M.; Mǎrginean, N.; Bucurescu, D.; Deleanu, D.; Filipescu, D.; Florea, N. M.; Gheorghe, I.; GhiÅ£ǎ, D.; Glodariu, T.; Lica, R.; Mǎrginean, R.; Mihai, C.; Negret, A.; Sava, T.; Stroe, L.; Şuvǎilǎ, R.; Toma, S.; Alharbi, T.; Alexander, T.; Aydin, S.; Brown, B. A.; Browne, F.; Carroll, R. J.; Mulholland, K.; Podolyák, Zs.; Regan, P. H.; Smith, J. F.; Smolen, M.; Townsley, C. M.

2016-01-01

The 1 i13/2→1 h9/2 (M 2 ) and 3 s1/2→2 f7/2 (E 3 ) reduced proton transition probabilities in Bi20983 have been determined from the direct half-life measurements of the 13/21+ and 1/21+ states using the Romanian array for γ -ray SPectroscopy in HEavy ion REactions (RoSPHERE). The 13/21+ and 1/21+ states were found to have T1/2=0.120 (15 ) ns and T1/2=9.02 (24 ) ns respectively. Angular distribution measurements were used to determine an E 3 /M 2 mixing ratio of δ =-0.184 (13 ) for the 1609 keV γ -ray transition deexciting the 13/21+ state. This value for δ was combined with the measured half-life to give reduced transition probabilities of B (E 3 ,13/21+→9/21-) =12 (2 ) ×103 e2fm6 and B (M 2 ,13/21+→9/21-) =38 (5 ) μN2fm2 . These values are in good agreement with calculations within the finite Fermi system. The extracted value of B (E 3 ,1/21+→7/21-) =6.3 (2 ) ×103 e2fm6 can be explained by a small (˜6 % ) admixture in the wave function of the 1/21+ state.

Measuring the B(E2) of the 1/2- ->3/2- transition in 7 Be

NASA Astrophysics Data System (ADS)

Henderson, S. L.; Ahn, T.; Caprio, M. A.; Constantinou, Ch.; Simon, A.; Twinsol Collaboration

2017-09-01

Ab-initio methods have been successful in describing the structure of light nuclei using realistic nucleon-nucleon interactions, but more experimental data is needed for light unstable nuclei. Recent no-core configuration interaction calculations have made predictions for the ratio of E2 transition strengths for the first excited state transition in 7 Be and 7 Li . Additional calculations that include clustering effects show a significant difference in the 7 Be and 7 Li B(E2) value. The E2 transition strength of the 7 Be first excited state has never been measured, which provides an interesting opportunity to investigate the accuracy of these calculations. To measure this E2 transition strength, a Coulomb Excitation experiment was performed at the University of Notre Dame. 7 Be was produced and separated using TwinSol. A beam of 7 Be ions were scattered off a gold target and the gamma rays from the inelastically scattered ions were detected using six clover Ge detectors. The most recent results for the E2 transition strength and its comparison to the no-core configuration interaction approach will be shown. In addition, new systematic checks on the experiment will be presented including the first stages of a Geant4 simulation to help account for beam anisotropies. This work has been supported by US NSF Grant No. PHY 14-19765 and DOE Grant Number DE-FG02-95ER-40934.

Spectroscopy and high-spin structure of 210Fr: Isomerism and potential evidence for configuration mixing

NASA Astrophysics Data System (ADS)

Margerin, V.; Lane, G. J.; Dracoulis, G. D.; Palalani, N.; Smith, M. L.; Stuchbery, A. E.

2016-06-01

The structure of 210Fr has been established up to an excitation energy of ˜5.5 MeV and spins of ˜25 ℏ , via time-correlated γ -ray spectroscopy and using the 197Au(18O,5 n )210Fr reaction with pulsed beams at an energy of 97 MeV. A significantly different level scheme has been obtained compared to previous publications. Several isomers are reported here, including a Jπ=(23) +,τ =686 (9 ) -ns state at 4417 keV and a 10-, 29.8(11)-ns state at 1113 keV. The former isomer has been associated with the π (h9/2 3i13/2 2) ν (p1/2 -2f5/2 -1) configuration and decays via proposed E 3 transitions with strengths of 8.4(3) and 21.2(8) W.u. There are only very few known cases of a high-spin isomer decaying via two parallel E 3 transitions. Indeed, this is not seen in other Fr nuclei, and consequently these strengths differ from related decays in the neighboring isotopes. However, by examining the systematics of E 3 transitions in trans-lead nuclei, we suggest that the weaker of the two transitions decays to a mixed 20- state. Systematics of the 10- isomer are also discussed. Comparisons are made between the observed spectrum of states and those predicted from semiempirical shell-model calculations.

26 CFR 1.401(e)-4 - Contributions for premiums on annuity, etc., contracts and transitional rule for certain excess...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Contributions for premiums on annuity, etc., contracts and transitional rule for certain excess contributions. 1.401(e)-4 Section 1.401(e)-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus...

77 FR 4787 - Department of Defense Task Force on the Care, Management, and Transition of Recovering Wounded...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

..., Management, and Transition of Recovering Wounded, Ill, and Injured Members of the Armed Forces; Amended... of the Department of Defense Task Force on the Care, Management, and Transition of Recovering Wounded... edition of the Federal Register (77 FR 3454) is amended to reflect changes in the meeting times and agenda...

A shock-tube measurement of the SiO/E 1 Sigma + - X 1 Sigma +/ transition moment

NASA Technical Reports Server (NTRS)

Park, C.

1978-01-01

The sum of the squares of the electronic transition moments for the (E 1 Sigma +) - (X 1 Sigma +) band system of SiO has been determined from absorption measurements conducted in the reflected-shock region of a shock tube. The test gas produced by shock-heating a mixture of SiCl4, N2O, and Ar, and the spectra were recorded photographically in the 150-230-nm wavelength range. The values of the sum of the squares were determined by comparing the measured absorption spectra with those produced by a line-by-line synthetic spectrum calculation. The value so deduced at an r-centroid value of 3.0 bohr was 0.86 + or - 0.10 atomic unit.

E+ Transition in GaAs1-xNx and GaAs1-xBix Due to Isoelectronic-Impurity-Induced Perturbation of the Conduction Band

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fluegel, B.; Mascarenhas, A.; Ptak, A. J.

2007-01-01

An above-band-gap transition E{sub +} is experimentally observed in the dilute GaAs{sub 1-x}Bi{sub x} alloy. Precise measurements at very low dilutions are made of the above-band-gap transition E{sub +} that is observed in GaAs{sub 1-x}N{sub x}, making it possible to compare the behavior of the different isoelectronic traps Bi and N in the common host GaAs with respect to their perturbation to the host electronic structure. We suggest that the origin of the E{sub +} level observed in GaAs is not the isolated isoelectronic impurity level N{sub x}, as is presumed in the band-anticrossing model, but rather the isoelectronic-impurity-induced perturbationmore » of the conduction band L{sub 6}{sup c}.« less

Radiative rates for forbidden M1 and E2 transitions of astrophysical interest in doubly ionized iron-peak elements

NASA Astrophysics Data System (ADS)

Fivet, V.; Quinet, P.; Bautista, M. A.

2016-01-01

Aims: Accurate and reliable atomic data for lowly ionized Fe-peak species (Sc, Ti, V, Cr, Mn, Fe, Co, and Ni) are of paramount importance for analyzing the high-resolution astrophysical spectra currently available. The third spectra of several iron group elements have been observed in different galactic sources, such as Herbig-Haro objects in the Orion Nebula and stars like Eta Carinae. However, forbidden M1 and E2 transitions between low-lying metastable levels of doubly charged iron-peak ions have been investigated very little so far, and radiative rates for those lines remain sparse or nonexistent. We attempt to fill that gap and provide transition probabilities for the most important forbidden lines of all doubly ionized iron-peak elements. Methods: We carried out a systematic study of the electronic structure of doubly ionized Fe-peak species. The magnetic dipole (M1) and electric quadrupole (E2) transition probabilities were computed using the pseudo-relativistic Hartree-Fock (HFR) code of Cowan and the central Thomas-Fermi-Dirac-Amaldi potential approximation implemented in AUTOSTRUCTURE. This multiplatform approach allowed for consistency checks and intercomparison and has proven very useful in many previous works for estimating the uncertainties affecting the radiative data. Results: We present transition probabilities for the M1 and E2 forbidden lines depopulating the metastable even levels belonging to the 3dk and 3dk-14s configurations in Sc III (k = 1), Ti III (k = 2), V III (k = 3), Cr III (k = 4), Mn III (k = 5), Fe III (k = 6), Co III (k = 7), and Ni III (k = 8).

The Apollo Number: Space Suits, Self-Support, and the Walk-Run Transition

PubMed Central

Carr, Christopher E.; McGee, Jeremy

2009-01-01

Background How space suits affect the preferred walk-run transition is an open question with relevance to human biomechanics and planetary extravehicular activity. Walking and running energetics differ; in reduced gravity (<0.5 g), running, unlike on Earth, uses less energy per distance than walking. Methodology/Principal Findings The walk-run transition (denoted *) correlates with the Froude Number (Fr = v2/gL, velocity v, gravitational acceleration g, leg length L). Human unsuited Fr* is relatively constant (∼0.5) with gravity but increases substantially with decreasing gravity below ∼0.4 g, rising to 0.9 in 1/6 g; space suits appear to lower Fr*. Because of pressure forces, space suits partially (1 g) or completely (lunar-g) support their own weight. We define the Apollo Number (Ap = Fr/M) as an expected invariant of locomotion under manipulations of M, the ratio of human-supported to total transported mass. We hypothesize that for lunar suited conditions Ap* but not Fr* will be near 0.9, because the Apollo Number captures the effect of space suit self-support. We used the Apollo Lunar Surface Journal and other sources to identify 38 gait events during lunar exploration for which we could determine gait type (walk/lope/run) and calculate Ap. We estimated the binary transition between walk/lope (0) and run (1), yielding Fr* (0.36±0.11, mean±95% CI) and Ap* (0.68±0.20). Conclusions/Significance The Apollo Number explains 60% of the difference between suited and unsuited Fr*, appears to capture in large part the effects of space suits on the walk-run transition, and provides several testable predictions for space suit locomotion and, of increasing relevance here on Earth, exoskeleton locomotion. The knowledge of how space suits affect gait transitions can be used to optimize space suits for use on the Moon and Mars. PMID:19672305

76 FR 36285 - Establishment of Class E Airspace; Brunswick, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

...-0116; Airspace Docket No. 11-ANE-1] Establishment of Class E Airspace; Brunswick, ME AGENCY: Federal... at Brunswick, ME, to accommodate the additional airspace needed for the Standard Instrument Approach... Executive Airport, Brunswick, ME (75 FR 14824) Docket No. FAA-2011-0116. Interested parties were invited to...

The E(2) symmetry and quantum phase transition in the two-dimensional limit of the vibron model

NASA Astrophysics Data System (ADS)

Zhang, Yu; Pan, Feng; Liu, Yu-Xin; Draayer, J. P.

2010-11-01

We study in detail the relation between the two-dimensional Euclidean dynamical E(2) symmetry and the quantum phase transition in the two-dimensional limit of the vibron model, called the U(3) vibron model. Both geometric and algebraic descriptions of the U(3) vibron model show that structures of low-lying states at the critical point of the model with a quartic potential as its classical limit can be approximately described by the E(2) symmetry. We also fit the finite-size scaling exponent of the energy levels and E1 transition rates in the F(2) model, which is exactly the E(2) model but with truncation in its Hilbert subspace, as well as those at the critical point in the U(3) vibron model. The N-scaling power law around the critical point shows that the E(2) symmetry is well preserved even for cases with finite number of bosons. In addition, two kinds of experimentally accessible effective order parameters, such as the energy ratios E_{2_1}/E_{1_1}, E_{3_1}/E_{1_1} and E1 transition ratios \\frac{B(E1;2_1\\rightarrow 1_1)}{B(E1;1_1\\rightarrow 0_1)}, \\frac{B(E1;0_2\\rightarrow 1_1)}{B(E1;1_1\\rightarrow 0_1)}, are proposed to identify the second-order phase transition in such systems. Possible empirical examples exhibiting approximate E(2) symmetry are also presented.

Anchoring Energy Measurements at the Aqueous Phase/Liquid Crystal Interface with Cationic Surfactants Using Magnetic Fréedericksz Transition.

PubMed

Yesil, Fatma; Suwa, Masayori; Tsukahara, Satoshi

2018-01-09

We constructed the apparatus to observe the Fréedericksz transition of liquid crystal in contact with water. The Fréedericksz transition is a distortion of nematic liquid crystals (LCs) induced by external fields. In the present system, sweeping homogeneous magnetic field was applied to the sample, and the distortion of the LC was visualized with a polarized light microscope with the crossed Nichols configuration. The anchoring energy (W AQ/LC ) at the aqueous phase/LC interface was measured in the presence of surfactant from the threshold magnetic field of the Fréedericksz transition. We studied two cationic surfactants: dodecyltrimethylammonium bromide and tetradecyltrimethylammonium bromide. A nematic LC, 4-cyano-4'-pentylbiphenyl (5CB), was examined, which was confined in a copper grid on an octadecyltrichlorosilane-treated microscope glass plate. Measured W AQ/LC were reproducible and showed consistence with the reported region for the water/LC interface. Interfacial excess of surfactants was also measured by the pendant drop method, and the relationship between the obtained W AQ/LC and the interfacial excess was investigated. Experiments showed that an increase in the anchoring energy depends on the surfactant and its interfacial excess. The region of the interfacial coverage, at which W AQ/LC increases, varied with the chain length of the surfactant. The measurement of the anchoring energy will provide new fundamental information on aqueous phase/LC interface.

Word Frequency Analysis. MOS: 62E. Skill Levels 1 & 2.

DTIC Science & Technology

1981-05-01

j., JtU I J ’I JT S EiM. ’J~VERSA. 5 *J (Jtl~iL I ’JSJP 1 J LUSE t J &USED 5 1 .3 u51’G 3 J .3 UTZLI ATEICN 2 J & VALVE 1 0 J3 EVISUAL I .3 fVj5JLY 2...ECOVERY I 7TI;1Irk 9 REVI1VE I RECTLY 2 PEO 4 i:’ 1 R.EC13CED ? Rr.~vl I IlFr~k 44 RcFFZ(E: ; I Ff ," TF1 ’. I 1 !E* ST EPS 4 1 RELL..SSD 7 PkLIF I RELI~E t

High-precision photometry of WASP-12 b transits

NASA Astrophysics Data System (ADS)

Maciejewski, G.; Errmann, R.; Raetz, St.; Seeliger, M.; Spaleniak, I.; Neuhäuser, R.

2011-04-01

Aims: The transiting extrasolar planet WASP-12 b was found to be one of the most intensely irradiated exoplanets. It is unexpectedly bloated and is losing mass that may accrete into the host star. Our aim was to refine the parameters of this intriguing system and search for signs of transit timing variations. Methods: We gathered high-precision light curves for two transits of WASP-12 b. Assuming various limb-darkening laws, we generated best-fitting models and redetermined the parameters of the system. Error estimates were derived by the prayer-bead method and Monte Carlo simulations. Results: System parameters obtained by us are found to agree with previous studies within one sigma. Use of the non-linear limb-darkening laws results in the best-fitting models. With two new mid-transit times, the ephemeris was refined to BJDTDB = (2 454 508.97682 ± 0.00020) + (1.09142245 ± 0.00000033)E. Interestingly, indications of transit timing variation are detected at the level of 3.4 sigma. This signal can be induced by an additional planet in the system. Simplified numerical simulations show that a perturber could be a terrestrial-type planet if both planets are in a low-order orbital resonance. However, we emphasise that further observations are needed to confirm variation and to constrain properties of the perturber. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA), operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofisica de Andalucia (CSIC).Photometric data are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/528/A65

Identification of significant E0 strength in the 22+ → 21+ transitions of 58,60,62Ni

NASA Astrophysics Data System (ADS)

Evitts, L. J.; Garnsworthy, A. B.; Kibédi, T.; Smallcombe, J.; Reed, M. W.; Brown, B. A.; Stuchbery, A. E.; Lane, G. J.; Eriksen, T. K.; Akber, A.; Alshahrani, B.; de Vries, M.; Gerathy, M. S. M.; Holt, J. D.; Lee, B. Q.; McCormick, B. P.; Mitchell, A. J.; Moukaddam, M.; Mukhopadhyay, S.; Palalani, N.; Palazzo, T.; Peters, E. E.; Ramirez, A. P. D.; Stroberg, S. R.; Tornyi, T.; Yates, S. W.

2018-04-01

The E0 transition strength in the 22+ →21 + transitions of 58,60,62Ni have been determined for the first time following a series of measurements at the Australian National University (ANU) and the University of Kentucky (UK). The CAESAR Compton-suppressed HPGe array and the Super-e solenoid at ANU were used to measure the δ (E 2 / M 1) mixing ratio and internal conversion coefficient of each transition following inelastic proton scattering. Level half-lives, δ (E 2 / M 1) mixing ratios and γ-ray branching ratios were measured at UK following inelastic neutron scattering. The new spectroscopic information was used to determine the E0 strengths. These are the first 2+ →2+E0 transition strengths measured in nuclei with spherical ground states and the E0 component is found to be unexpectedly large; in fact, these are amongst the largest E0 transition strengths in medium and heavy nuclei reported to date.

Isotope shifts in francium isotopes Fr 206 - 213 and Fr 221

DOE PAGES

Collister, R.; Gwinner, G.; Tandecki, M.; ...

2014-11-07

We present the isotope shifts of the 7s 1/2 to 7p 1/2 transition for francium isotopes ²⁰⁶⁻²¹³Fr with reference to ²²¹Fr collected from two experimental periods. The shifts are measured on a sample of atoms prepared within a magneto-optical trap by a fast sweep of radio-frequency sidebands applied to a carrier laser. King plot analysis, which includes literature values for 7s 1/2 to 7p 3/2 isotope shifts, provides a field shift constant ratio of 1.0520(10) and a difference between the specific mass shift constants of 170(100) GHz amu between the D₁ and D₂ transitions, of sufficient precision to differentiate betweenmore » ab initio calculations.« less

Measurement of the ϕ → π0e+e- transition form factor with the KLOE detector

NASA Astrophysics Data System (ADS)

Anastasi, A.; Babusci, D.; Bencivenni, G.; Berlowski, M.; Bloise, C.; Bossi, F.; Branchini, P.; Budano, A.; Caldeira Balkeståhl, L.; Cao, B.; Ceradini, F.; Ciambrone, P.; Curciarello, F.; Czerwiński, E.; D'Agostini, G.; Danè, E.; De Leo, V.; De Lucia, E.; De Santis, A.; De Simone, P.; Di Cicco, A.; Di Domenico, A.; Di Salvo, R.; Domenici, D.; D'Uffizi, A.; Fantini, A.; Felici, G.; Fiore, S.; Gajos, A.; Gauzzi, P.; Giardina, G.; Giovannella, S.; Graziani, E.; Happacher, F.; Heijkenskjöld, L.; Ikegami Andersson, W.; Johansson, T.; Kamińska, D.; Krzemien, W.; Kupsc, A.; Loffredo, S.; Mandaglio, G.; Martini, M.; Mascolo, M.; Messi, R.; Miscetti, S.; Morello, G.; Moricciani, D.; Moskal, P.; Papenbrock, M.; Passeri, A.; Patera, V.; Perez del Rio, E.; Ranieri, A.; Salabura, P.; Santangelo, P.; Sarra, I.; Schioppa, M.; Silarski, M.; Sirghi, F.; Tortora, L.; Venanzoni, G.; Wiślicki, W.; Wolke, M.

2016-06-01

A measurement of the vector to pseudoscalar conversion decay ϕ →π0e+e- with the KLOE experiment is presented. A sample of ˜9500 signal events was selected from a data set of 1.7 fb-1 of e+e- collisions at √{ s} ˜mϕ collected at the DAΦNE e+e- collider. These events were used to perform the first measurement of the transition form factor |Fϕπ0 (q2) | and a new measurement of the branching ratio of the decay: BR (ϕ →π0e+e-) = (1.35 ±0.05-0.10+0.05) ×10-5. The result improves significantly on previous measurements and is in agreement with theoretical predictions.

Pressure-induced topological insulator-to-metal transition and superconductivity in Sn-doped B i1.1S b0.9T e2S

NASA Astrophysics Data System (ADS)

An, Chao; Chen, Xuliang; Wu, Bin; Zhou, Yonghui; Zhou, Ying; Zhang, Ranran; Park, Changyong; Song, Fengqi; Yang, Zhaorong

2018-05-01

Tetradymite-type topological insulator Sn-doped B i1.1S b0.9T e2S (Sn-BSTS), with a surface state Dirac point energy well isolated from the bulk valence and conduction bands, is an ideal platform for studying the topological transport phenomena. Here, we present high-pressure transport studies on single-crystal Sn-BSTS, combined with Raman scattering and synchrotron x-ray diffraction measurements. Over the studied pressure range of 0.7-37.2 GPa, three critical pressure points can be observed: (i) At ˜9 GPa, a pressure-induced topological insulator-to-metal transition is revealed due to closure of the bulk band gap, which is accompanied by changes in slope of the Raman frequencies and a minimum in c /a within the pristine rhombohedral structure (R -3 m ); (ii) at ˜13 GPa, superconductivity is observed to emerge, along with the R -3 m to a C 2 /c (monoclinic) structural transition; (iii) at ˜24 GPa, the superconducting transition onset temperature TC reaches a maximum of ˜12 K , accompanied by a second structural transition from the C 2 /c to a body-centered cubic I m -3 m phase.

77 FR 40459 - Electronic Fund Transfers (Regulation E); Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

... Electronic Fund Transfers (Regulation E); Correction AGENCY: Bureau of Consumer Financial Protection. ACTION... published the Final Rule (77 FR 6194), which implements the Electronic Fund Transfer Act, and the official... Sec. 1005.3(a) in the interim final rule, Electronic Fund Transfers (Regulation E), published on...

Histological distribution of FR-1, a cyclic RGDS-peptide, binding sites during early embryogenesis, and isolation and initial characterization of FR-1 receptor in the sand dollar embryo.

PubMed

Katow, H; Yamamoto, Y; Sofuku, S

1997-04-01

A fibronectin-related synthetic cyclic H-Cys-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Cys-OH (RGDSPASS) peptide (FR-1) binding site in the embryo of the sand dollar Clypeaster japonicus was specified using dansyl-labeled FR-1 (Dns-FR-1) and horseradish peroxidase-labeled FR-1, and an FR-1 receptor was isolated using FR-1-affinity column chromatography. The FR-1 introduced to the blastocoel of blastulae inhibited primary mesenchyme cell (PMC) migration in mesenchyme blastulae, and complete gastrulation and spicule differentiation in gastrulae. The Dns-FR-1 bound to the entire basal side of the ectoderm in mesenchyme blastulae, and then restricted to the basal side of the ectoderm at the apical tuft region and the vegetal hemisphere in early gastrulae. The cytoplasm of the archenteron also bound to Dns-FR-1. In PMC, Dns-FR-1 bound to the nucleus and cytoplasmic reticular features. In unfertilized eggs, Dns-FR-1 bound to the entire cytoplasm, particularly to the oval-shaped granules and the nuclear envelope, but only to the cytoplasm after fertilization. Relative molecular mass (Mr) of the FR-1-binding protein was 240 kDa under non-reducing conditions and 57 kDa under reducing conditions. The FR-1 receptor protein bound anti-sea urchin integrin (Spl) betaL subunit antibodies raised against the embryos of Strongylocentrotus purpuratus. Immunohistochemistry showed that the antibody binding site was similar to the histochemical distribution of Dns-FR-1. However, Mr of the FR-1 receptor is distinctively larger than that of the Spl betaL subunit.

75 FR 13667 - Amendment of Class E Airspace; Huntingburg, IN

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-23

...; Airspace Docket No. 09-AGL-21] Amendment of Class E Airspace; Huntingburg, IN AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace at Huntingburg, IN... rulemaking to amend Class E airspace for Huntingburg Airport, Huntingburg, IN (74 FR 66592) Docket No. FAA...

77 FR 51464 - Amendment of Class E Airspace; Augusta, GA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-24

...-1334; Airspace Docket No. 11-ASO-43] Amendment of Class E Airspace; Augusta, GA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace in... amend Class E airspace in the Augusta, GA area (77 FR 21506). Interested parties were invited to...

75 FR 41075 - Amendment of Class E Airspace; Bozeman, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

...-1220; Airspace Docket No. 09-ANM-30] Amendment of Class E Airspace; Bozeman, MT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action will amend Class E airspace at... proposed rulemaking to amend Class E airspace at Bozeman, MT (75 FR 20321). Interested parties were invited...

75 FR 65226 - Establishment of Class E Airspace; Bamberg, SC

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

...-0685; Airspace Docket No. 10-ASO-27] Establishment of Class E Airspace; Bamberg, SC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E Airspace... Register a notice of proposed rulemaking to establish Class E airspace at Bamberg, SC (75 FR 52654) Docket...

Electron impact excitation of the q{sup 1}S {r_arrow}n{sup 1}P (n=3,4) transitions in helium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khakoo, M.A.; Rugamas, F.; Roundy, D.

1996-05-01

Experimental differential cross-section (DCS) ratios for the above transitions to the 1{sup 1}S {r_arrow} 2{sup 1}P transition are reported at impact energies of 30eV, 40eV and 80eV and scattering angles in the range of 5{degrees} to 130{degrees}. The data are an extension of previously reported work using the electron-photon coincidence method in the VUV. The DCS ratios are normalized to available absolute DCSs for the 1{sup 1}S {r_arrow} 2{sup 1}P transition and the resulting n{sup 1}P DCSs are compared to previous semi-empirical DCSs as well as available theory.

Isotope shifts in the 7 s →8 s transition of francium: Measurements and comparison to ab initio theory

NASA Astrophysics Data System (ADS)

Kalita, M. R.; Behr, J. A.; Gorelov, A.; Pearson, M. R.; DeHart, A. C.; Gwinner, G.; Kossin, M. J.; Orozco, L. A.; Aubin, S.; Gomez, E.; Safronova, M. S.; Dzuba, V. A.; Flambaum, V. V.

2018-04-01

We observe the electric-dipole forbidden 7 s →8 s transition in the francium isotopes Fr-211208 and 213Fr using a two-photon excitation scheme. We collect the atoms online from an accelerator and confine them in a magneto-optical trap for the measurements. In combination with previous measurements of the 7 s →7 p1 /2 transition we perform a King plot analysis. We compare the thus-determined ratio of the field shift constants (1.228 ± 0.019) to results obtained from new ab initio calculations (1.234 ± 0.010).

Pressure-induced magnetic collapse and metallization of TlF e1.6S e2

NASA Astrophysics Data System (ADS)

Naumov, P. G.; Filsinger, K.; Shylin, S. I.; Barkalov, O. I.; Ksenofontov, V.; Qi, Y.; Palasyuk, T.; Schnelle, W.; Medvedev, S. A.; Greenblatt, M.; Felser, C.

2017-08-01

The crystal structure, magnetic ordering, and electrical resistivity of TlF e1.6S e2 were studied at high pressures. Below ˜7 GPa , TlF e1.6S e2 is an antiferromagnetically ordered semiconductor with a ThC r2S i2 -type structure. The insulator-to-metal transformation observed at a pressure of ˜7 GPa is accompanied by a loss of magnetic ordering and an isostructural phase transition. In the pressure range ˜7.5 -11 GPa a remarkable downturn in resistivity, which resembles a superconducting transition, is observed below 15 K. We discuss this feature as the possible onset of superconductivity originating from a phase separation in a small fraction of the sample in the vicinity of the magnetic transition.

76 FR 55555 - Amendment of Class E Airspace; Shelby, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

...-0280; Airspace Docket No. 11-ASO-16] Amendment of Class E Airspace; Shelby, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace at Shelby, NC, to... rulemaking to amend Class E airspace at Shelby, NC (76 FR 35799) Docket No. FAA-2011-0280. Interested parties...

78 FR 26243 - Amendment of Class E Airspace; Easton, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

...-0394; Airspace Docket No. 12-AEA-8] Amendment of Class E Airspace; Easton, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace at Easton, PA, as the... (NPRM) to amend Class E airspace at Easton, PA (78 FR 5152) Docket No. FAA-2012-0394. Interested parties...

Electric Quadrupole E2- Transitions of 170-174 Yb Isotopes

NASA Astrophysics Data System (ADS)

Abu El Sheikh, Mohd Kh. M.; Okhunov, Abdurahim A.; Usmanov, Ph. N.; Hassan, Torla HJ

2017-12-01

The non-adiabatic effects which is manifested in the electric properties of low-lying states of even-even deformed nuclei are studied. A simple phenomenological model which takes into account the Coriolis mixing of {K}π ={0}n+,{2}n+ and {K}π ={1}ν + state bands. The Calculations for isotopes 170-174 Yb, are carried out. The reduced probability of electric quadrupole transitions from the states {0}ν + and {2}ν + - bands to the ground (gr) state band is calculated and non adiabatic effect is discussed. The ratio of E2- transitions RIK from {0}2+, {0}3+, {2}1+, and {2}2+ bands are calculated and compared with the experimental data.

Kepler-432 b: a massive planet in a highly eccentric orbit transiting a red giant

NASA Astrophysics Data System (ADS)

Ciceri, S.; Lillo-Box, J.; Southworth, J.; Mancini, L.; Henning, Th.; Barrado, D.

2015-01-01

We report the first disclosure of the planetary nature of Kepler-432 b (aka Kepler object of interest KOI-1299.01). We accurately constrained its mass and eccentricity by high-precision radial velocity measurements obtained with the CAFE spectrograph at the CAHA 2.2-m telescope. By simultaneously fitting these new data and Kepler photometry, we found that Kepler-432 b is a dense transiting exoplanet with a mass of Mp = 4.87 ± 0.48MJup and radius of Rp = 1.120 ± 0.036RJup. The planet revolves every 52.5 d around a K giant star that ascends the red giant branch, and it moves on a highly eccentric orbit with e = 0.535 ± 0.030. By analysing two near-IR high-resolution images, we found that a star is located at 1.1'' from Kepler-432, but it is too faint to cause significant effects on the transit depth. Together with Kepler-56 and Kepler-91, Kepler-432 occupies an almost-desert region of parameter space, which is important for constraining the evolutionary processes of planetary systems. RV data (Table A.1) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/573/L5

Transition of a small-bipolaron gas to a Fröhlich polaron in a deformable lattice

NASA Astrophysics Data System (ADS)

Hettiarachchi, Gayan Prasad; Muhid, Mohd Nazlan Mohd; Hamdan, Halimaton

2018-04-01

The electronic properties of guest Cs atoms in a deformable lattice are investigated at various densities n . Low values of n show optical absorptions of small bipolarons. At intermediate n values, new bands appear in the midinfrared (MIR) and high-frequency regions, which coexist with the small bipolaron bands. With a further increase in n , the small bipolaron bands become less discernible and subsequently disappear, resulting in the appearance of a Drude component superimposed on a MIR sideband suggesting a phase transition to a polaronic metal. In this itinerant phase, an approximately twofold mass enhancement is observed. This continuous transition of a gas of small bipolarons to a polaronic metal characterized by a Fröhlich polaron reveals an important part of the complex phase diagram of the metal-insulator transition in a deformable lattice.

Open Charm Contributions to the E1 Transitions of ψ (3686) and ψ (3770) to γ χ cJ

NASA Astrophysics Data System (ADS)

Cao, Zheng; Cleven, Martin; Wang, Qian; Zhao, Qiang

In this proceeding, we present our recent study of the open charm effects in the E1 transitions of ψ (3686) and ψ (3770) to γ χ cJ in a non-relativistic effective field theory (NREFT) in which several systematical effects are included. We find that these open charm contributions play an essential role in understanding the large discrepancies between the non-relativistic leading order calculations and the experimental data.

MASCARA-1 b. A hot Jupiter transiting a bright mV = 8.3 A-star in a misaligned orbit

NASA Astrophysics Data System (ADS)

Talens, G. J. J.; Albrecht, S.; Spronck, J. F. P.; Lesage, A.-L.; Otten, G. P. P. L.; Stuik, R.; Van Eylen, V.; Van Winckel, H.; Pollacco, D.; McCormac, J.; Grundahl, F.; Fredslund Andersen, M.; Antoci, V.; Snellen, I. A. G.

2017-10-01

We report the discovery of MASCARA-1 b, which is the first exoplanet discovered with the Multi-site All-Sky CAmeRA (MASCARA). This exoplanet is a hot Jupiter orbiting a bright mV = 8.3, rapidly rotating (vsini⋆ > 100 km s-1) A8 star with a period of 2.148780 ± 8 × 10-6 days. The planet has a mass and radius of 3.7 ± 0.9 MJup and 1.5 ± 0.3 RJup, respectively. As with most hot Jupiters transiting early-type stars, we find a misalignment between the planet orbital axis and the stellar spin axis, which may be a signature of the formation and migration histories of this family of planets. MASCARA-1 b has a mean density of 1.5 ± 0.9 g cm-3 and an equilibrium temperature of 2570+50-30K, that is one of the highest temperatures known for a hot Jupiter to date. The system is reminiscent of WASP-33, but the host star lacks apparent delta-scuti variations, making the planet an ideal target for atmospheric characterization. We expect this to be the first of a series of hot Jupiters transiting bright early-type stars that will be discovered by MASCARA. Tables of the photometry and the reduced spectra as FITS files are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/606/A73

78 FR 72009 - Establishment of Class E Airspace; Star, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

...-0440; Airspace Docket No. 13-ASO-10] Establishment of Class E Airspace; Star, NC AGENCY: Federal... at Star, NC, to accommodate a new Area Navigation (RNAV) Global Positioning System (GPS) Standard... Federal Register a notice of proposed rulemaking to establish Class E airspace at Star, NC (78 FR 54413...

The role of molecular gas in galaxy transition in compact groups

NASA Astrophysics Data System (ADS)

Lisenfeld, U.; Alatalo, K.; Zucker, C.; Appleton, P. N.; Gallagher, S.; Guillard, P.; Johnson, K.

2017-11-01

Compact groups (CGs) provide an environment in which interactions between galaxies and with the intra-group medium enable and accelerate galaxy transitions from actively star forming to quiescent. Galaxies in transition from active to quiescent can be selected, by their infrared (IR) colors, as canyon or infrared transition zone (IRTZ) galaxies. We used a sample of CG galaxies with IR data from the Wide Field Infrared Survey Explorer (WISE) allowing us to calculate the stellar mass and star formation rate (SFR) for each galaxy. Furthermore, we present new CO(1-0) data for 27 galaxies and collect data from the literature to calculate the molecular gas mass for a total sample of 130 galaxies. This data set allows us to study the difference in the molecular gas fraction (Mmol/M∗) and star formation efficiency (SFE = SFR/Mmol) between active, quiescent, and transitioning (I.e., canyon and IRTZ) galaxies. We find that transitioning galaxies have a mean molecular gas fraction and a mean SFE that are significantly lower than those of actively star-forming galaxies. The molecular gas fraction is higher than that of quiescent galaxies, whereas the SFE is similar. These results indicate that the transition from actively star-forming to quiescent in CG galaxies goes along with a loss of molecular gas, possibly due to tidal forces exerted from the neighboring galaxies or a decrease in the gas density. In addition, the remaining molecular gas loses its ability to form stars efficiently, possibly owing to turbulence perturbing the gas,as seen in other, well-studied examples such as Stephan's Quintet and HCG 57. Thus, the amount and properties of molecular gas play a crucial role in the environmentally driven transition of galaxies from actively star forming to quiescent. Full Table 2 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/607/A110

Transit Recovery of Kepler-167e: Providing JWST with an Unprecedented Jupiter-analog Exoplanet Target

NASA Astrophysics Data System (ADS)

Dalba, Paul; Muirhead, Philip; Tamburo, Patrick

2018-05-01

The Kepler Mission has uncovered a handful of long-period transiting exoplanets that orbit in the cold outer reaches of their systems, despite their low transit probabilities. Recent work suggests that cold gas giant exoplanet atmospheres are amenable to transmission spectroscopy (the analysis of the transit depth versus wavelength) enabling novel tests of planetary formation and evolution theories. Of particular scientific interest is Kepler-167e, a low-eccentricity Jupiter-analog exoplanet with a 1,071-day orbital period residing well beyond the snow-line. Transmission spectroscopy of Kepler-167e from JWST can reveal the composition of this planet's atmosphere, constrain its heavy-element abundance, and identify atmospheric photochemical processes. JWST characterization also enables unprecedented direct comparison with Jupiter and Saturn, which show a striking diversity in physical properties that is best investigated through comparative exoplanetology. Since Kepler only observed two transits of Kepler-167e, it is not known if this exoplanet exhibits transit timing variations (TTVs). About half of Kepler's long-period exoplanets have TTVs of up to 40 hours. Such a large uncertainty jeopardizes attempts to characterize the atmosphere of this unique Jovian exoplanet with JWST. To mitigate this risk, the upcoming third transit of Kepler-167e must be observed to test for TTVs. We propose a simple 10-hour, single-channel observation to capture ingress or egress of the next transit of Kepler-167e in December 2018. In the absence of TTVs, our observation will reduce the ephemeris uncertainty from an unknown value to approximately 3 minutes, thereby removing the risk in future transit observations with JWST. The excellent photometric precision of Spitzer is sufficient to identify the transit of Kepler-167e. Given the timing and nature of this program, Spitzer is the only observatory--on the ground or in space--that can make this pivotal observation.

Electron impact excitation of the 1{sup 1}{ital S}{r_arrow}3{sup 1}{ital P} transition in helium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khakoo, M.A.; Roundy, D.; Rugamas, F.

1995-07-03

In the first direct application of the electron-photon coincidence technique for differential cross-section measurements, experimentally determined ratios of the differential cross sections for the electron impact excitation of the 1{sup 1}{ital S}{r_arrow}2{sup 1}{ital P} to the 1{sup 1}{ital S}{r_arrow}3{sup 1}{ital P} transitions are presented at 30 and 40 eV incident electron energies. Differential cross sections for the 1{sup 1}{ital S}{r_arrow}3{sup 1}{ital P} transitions are derived by normalizing these ratios to available experimental differential cross sections for the 1{sup 1}{ital S}{r_arrow}2{sup 1}{ital P} transition.

Copy number and haplotype variation at the VRN-A1 and central FR-A2 loci are associated with frost tolerance in hexaploid wheat.

PubMed

Zhu, Jie; Pearce, Stephen; Burke, Adrienne; See, Deven Robert; Skinner, Daniel Z; Dubcovsky, Jorge; Garland-Campbell, Kimberly

2014-05-01

The interaction between VRN - A1 and FR - A2 largely affect the frost tolerance of hexaploid wheat. Frost tolerance is critical for wheat survival during cold winters. Natural variation for this trait is mainly associated with allelic differences at the VERNALIZATION 1 (VRN1) and FROST RESISTANCE 2 (FR2) loci. VRN1 regulates the transition between vegetative and reproductive stages and FR2, a locus including several tandemly duplicated C-REPEAT BINDING FACTOR (CBF) transcription factors, regulates the expression of Cold-regulated genes. We identified sequence and copy number variation at these two loci among winter and spring wheat varieties and characterized their association with frost tolerance. We identified two FR-A2 haplotypes-'FR-A2-S' and 'FR-A2-T'-distinguished by two insertion/deletions and ten single nucleotide polymorphisms within the CBF-A12 and CBF-A15 genes. Increased copy number of CBF-A14 was frequently associated with the FR-A2-T haplotype and with higher CBF14 transcript levels in response to cold. Factorial ANOVAs revealed significant interactions between VRN1 and FR-A2 for frost tolerance in both winter and spring panels suggesting a crosstalk between vernalization and cold acclimation pathways. The model including these two loci and their interaction explained 32.0 and 20.7 % of the variation in frost tolerance in the winter and spring panels, respectively. The interaction was validated in a winter wheat F 4:5 population segregating for both genes. Increased VRN-A1 copy number was associated with improved frost tolerance among varieties carrying the FR-A2-T allele but not among those carrying the FR-A2-S allele. These results suggest that selection of varieties carrying the FR-A2-T allele and three copies of the recessive vrn-A1 allele would be a good strategy to improve frost tolerance in wheat.

77 FR 5 - Amendment of Class E Airspace; Kipnuk, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-03

...-0866; Airspace Docket No. 11-AAL-15] Amendment of Class E Airspace; Kipnuk, AK AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies Class E airspace at Kipnuk, AK. The... a notice of proposed rulemaking (NPRM) to amend controlled airspace at Kipnuk, AK (76 FR 54149...

The detection of higher-order acoustic transitions is reflected in the N1 ERP.

PubMed

Weise, Annekathrin; Schröger, Erich; Horváth, János

2018-01-30

The auditory system features various types of dedicated change detectors enabling the rapid parsing of auditory stimulation into distinct events. The activity of such detectors is reflected by the N1 ERP. Interestingly, certain acoustic transitions show an asymmetric N1 elicitation pattern: whereas first-order transitions (e.g., a change from a segment of constant frequency to a frequency glide [c-to-g change]) elicit N1, higher-order transitions (e.g., glide-to-constant [g-to-c] changes) do not. Consensus attributes this asymmetry to the absence of any available sensory mechanism that is able to rapidly detect higher-order changes. In contrast, our study provides compelling evidence for such a mechanism. We collected electrophysiological and behavioral data in a transient-detection paradigm. In each condition, a random (50%-50%) sequence of two types of tones occurred, which did or did not contain a transition (e.g., c-to-g and constant stimuli or g-to-c and glide tones). Additionally, the rate of pitch change of the glide varied (i.e., 10 vs. 40 semitones per second) in order to increase the number of responding neural assemblies. The rate manipulation modulated transient ERPs and behavioral detection performance for g-to-c transitions much stronger than for c-to-g transitions. The topographic and tomographic analyses suggest that the N1 response to c-to-g and also to g-to-c transitions emerged from the superior temporal gyrus. This strongly supports a sensory mechanism that allows the fast detection of higher-order changes. © 2018 Society for Psychophysiological Research.

Angular distributions in the reactions pp-->χ1,2-->γψ-->γe+e-

NASA Astrophysics Data System (ADS)

Baglin, C.; Baird, S.; Bassompierre, G.; Borreani, G.; Brient, J.-C.; Broll, C.; Brom, J.-M.; Bugge, L.; Buran, T.; Burq, J.-P.; Bussière, A.; Buzzo, A.; Cester, R.; Chemarin, M.; Chevallier, M.; Escoubes, B.; Fay, J.; Ferroni, S.; Gracco, V.; Guillad, J.-P.; Khan-Aronsen, E.; Kirsebom, K.; Kylling, A.; Ille, B.; Lambert, M.; Leistam, L.; Lundby, A.; Macri, M.; Marchetto, F.; Menichetti, E.; Morch, C.; Mouëllic, B.; Olsen, D.; Pastrone, N.; Petrillo, L.; Pia, M. G.; Poole, J.; Poulet, M.; Rinaudo, G.; Santroni, A.; Severi, M.; Skjevling, G.; Stugu, B.

1987-08-01

In the experiment R704 at the CERN Intersecting Storage Rings, the two p-wave charmonium states χ1 and χ2 were formed directly in proton-antiproton annihilation, and detected through the decay chain χj-->γ+J/ψ-->ψ+e+e-. The angular d istributions of the events found are studied here. A maximum likehood analysis shows that χ1 radiative transition to the J/ψ is compatible with a pure dipole. Indications of a nonzero, positive quadropole contribution to the χ2 radiative transition are found. Finally, it is found that the χ2 data are consistent with the conventional assumption that a single quark radiates the photon in the transition from the χ2 to the J/ψ.

The impact of tissue Doppler index E/e' ratio on instantaneous wave-free ratio.

PubMed

Arashi, Hiroyuki; Yamaguchi, Junichi; Ri, Tonre; Otsuki, Hisao; Nakao, Masashi; Kamishima, Kazuho; Jujo, Kentaro; Minami, Yuichiro; Ogawa, Hiroshi; Hagiwara, Nobuhisa

2018-03-01

The instantaneous wave-free ratio (iFR) is a vasodilator-free, invasive pressure wire index of the functional severity of coronary stenosis and is calculated under resting conditions. In a recent study, iFR was found to be more closely linked to coronary flow reserve (CFR) than fractional flow reserve (FFR). E/e' is a surrogate marker of left ventricular (LV) filling pressure and LV diastolic dysfunction. Coronary resting flow was found to be increased in patients with elevated E/e', and higher coronary resting flow was associated with lower CFR. Higher baseline coronary flow induces a greater loss of translesional pressure and may affect iFR. However, no reports have examined the impact of E/e' on iFR. The purpose of this study was to assess the relationship between iFR and E/e' compared with FFR. We retrospectively examined 103 consecutive patients (142 with stenosis) whose iFR, FFR, and E/e' were measured simultaneously. The mean age, LV mass index, and systolic blood pressure of patients with elevated E/e' were higher than those of patients with normal E/e'. Although no significant differences were observed in mean FFR values and % diameter stenosis, the mean iFR value in patients with elevated E/e' was significantly lower than that in patients with normal E/e'. The iFR was negatively correlated with E/e', while there was no correlation between FFR and E/e'. Multivariate analysis showed that E/e' and % diameter stenosis were independent determinants of iFR. E/e' ratio affects iFR values. Our results suggest that FFR mainly reflects the functional severity of the epicardial stenosis whereas iFR could potentially be influenced by not only epicardial stenosis but also other factors related to LV filling pressure or LV diastolic dysfunction. Further research is needed to understand the underlying mechanisms that influence the evaluation of iFR in patients with elevated E/e'. Copyright © 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights

p- to n-type conductivity transition in 1.0 eV GaInNAs solar cells controlled by the V/III ratio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Langer, Fabian, E-mail: fabian.langer@physik.uni-wuerzburg.de; Perl, Svenja; Kamp, Martin

2015-02-09

In this work, we report a p- to n-type conductivity transition of GaInNAs (1.0 eV bandgap) layers in p-i-n dilute nitride solar cells continuously controlled by the V/III ratio during growth. Near the transition region, we were able to produce GaInNAs layers with very low effective electrically active doping concentrations resulting in wide depleted areas. We obtained internal quantum efficiencies (IQEs) up to 85% at 0.2 eV above the bandgap. However, the high IQE comes along with an increased dark current density resulting in a decreased open circuit voltage of about 0.2 V. This indicates the formation of non-radiant defect centers related tomore » the p-type to n-type transition. Rapid-thermal annealing of the solar cells on the one hand helps to anneal some of these defects but on the other hand increases the effective doping concentrations.« less

Hadronic transitions Υ(2S)-->Υ(1S)

NASA Astrophysics Data System (ADS)

P. Alexander, J.; Baker, R.; Bebek, C.; Berger, B. E.; Berkelman, K.; Bloom, K.; Boisvert, V.; Cassel, D. G.; Crowcroft, D. S.; Dickson, M.; von Dombrowski, S.; Drell, P. S.; Ecklund, K. M.; Ehrlich, R.; Foland, A. D.; Gaidarev, P.; Galik, R. S.; Gibbons, L.; Gittelman, B.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hopman, P. I.; Kandaswamy, J.; Kim, P. C.; Kreinick, D. L.; Lee, T.; Liu, Y.; Mistry, N. B.; Ng, C. R.; Nordberg, E.; Ogg, M.; Patterson, J. R.; Peterson, D.; Riley, D.; Soffer, A.; Valant-Spaight, B.; Ward, C.; Athanas, M.; Avery, P.; Jones, C. D.; Lohner, M.; Patton, S.; Prescott, C.; Yelton, J.; Zheng, J.; Brandenburg, G.; Briere, R. A.; Ershov, A.; Gao, Y. S.; Kim, D. Y.-J.; Wilson, R.; Yamamoto, H.; Browder, T. E.; Li, Y.; Rodriguez, J. L.; Bergfeld, T.; Eisenstein, B. I.; Ernst, J.; Gladding, G. E.; Gollin, G. D.; Hans, R. M.; Johnson, E.; Karliner, I.; Marsh, M. A.; Palmer, M.; Selen, M.; Thaler, J. J.; Edwards, K. W.; Bellerive, A.; Janicek, R.; Macfarlane, D. B.; Patel, P. M.; Sadoff, A. J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Darling, C.; Davis, R.; Kotov, S.; Kravchenko, I.; Kwak, N.; Zhou, L.; Anderson, S.; Kubota, Y.; Lee, S. J.; O'neill, J. J.; Poling, R.; Riehle, T.; Smith, A.; Alam, M. S.; Athar, S. B.; Ling, Z.; Mahmood, A. H.; Timm, S.; Wappler, F.; Anastassov, A.; Duboscq, J. E.; Fujino, D.; Gan, K. K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M. B.; Sung, M.; Undrus, A.; Wanke, R.; Wolf, A.; Zoeller, M. M.; Nemati, B.; Richichi, S. J.; Ross, W. R.; Severini, H.; Skubic, P.; Bishai, M.; Fast, J.; Hinson, J. W.; Menon, N.; Miller, D. H.; Shibata, E. I.; Shipsey, I. P.; Yurko, M.; Glenn, S.; Johnson, S. D.; Kwon, Y.; Roberts, S.; Thorndike, E. H.; Jessop, C. P.; Lingel, K.; Marsiske, H.; Perl, M. L.; Savinov, V.; Ugolini, D.; Wang, R.; Zhou, X.; Coan, T. E.; Fadeyev, V.; Korolkov, I.; Maravin, Y.; Narsky, I.; Shelkov, V.; Staeck, J.; Stroynowski, R.; Volobouev, I.; Ye, J.; Artuso, M.; Azfar, F.; Efimov, A.; Goldberg, M.; He, D.; Kopp, S.; Moneti, G. C.; Mountain, R.; Schuh, S.; Skwarnicki, T.; Stone, S.; Viehhauser, G.; Xing, X.; Bartelt, J.; Csorna, S. E.; Jain, V.; McLean, K. W.; Marka, S.; Godang, R.; Kinoshita, K.; Lai, I. C.; Pomianowski, P.; Schrenk, S.; Bonvicini, G.; Cinabro, D.; Greene, R.; Perera, L. P.; Zhou, G. J.; Chadha, M.; Chan, S.; Eigen, G.; Miller, J. S.; O'grady, C.; Schmidtler, M.; Urheim, J.; Weinstein, A. J.; Würthwein, F.; Bliss, D. W.; Masek, G.; Paar, H. P.; Prell, S.; Sharma, V.; Asner, D. M.; Gronberg, J.; Hill, T. S.; Lange, D. J.; Morrison, R. J.; Nelson, H. N.; Nelson, T. K.; Roberts, D.; Ryd, A.; Balest, R.; Behrens, B. H.; Ford, W. T.; Gritsan, A.; Park, H.; Roy, J.; Smith, J. G.

1998-09-01

Using a 73.6 pb-1 data sample of Υ(2S) events collected with the CLEO II detector at the Cornell Electron Storage Ring, we have investigated the hadronic transitions between the Υ(2S) and the Υ(1S). The dipion transition Υ(2S)-->Υ(1S)π+π- was studied using two different analysis techniques. Selecting events in which Υ(1S)-->e+e-,μ+μ- (``exclusive'' analysis), and using the Υ(1S) leptonic branching fractions world averages from the PDG review, we obtained B(Υ(2S)-->Υ(1S)π+π-)=0.189+/-0.004+/-0.010, while using a method allowing Υ(1S)-->anything (``inclusive'' analysis) we obtained B(Υ(2S)-->Υ(1S)π+π-)=0.196+/-0.002+/-0.010. The appropriate weighted average of the two measurements gives B(Υ(2S)-->Υ(1S)π+π-)=0.192+/-0.002+/-0.010. Combining the exclusive and inclusive results we derive the Υ(1S) leptonic branching fractions Bee=0.0229+/-0.0008+/-0.0011 and Bμμ=0.0249+/-0.0008+/-0.0013. We also studied Υ(2S)-->Υ(1S)π0π0 and obtained B(Υ(2S)-->Υ(1S)π0π0)=0.092+/-0.006+/-0.008. Parameters of the ππ system (dipion invariant mass spectra, angular distributions) were analyzed and found to be consistent with current theoretical models. Lastly, we searched for the η and single π0 transitions and obtained the 90% confidence level upper limits B(Υ(2S)-->Υ(1S)η)<0.0028 and B(Υ(2S)-->Υ(1S)π0)<0.0011.

77 FR 50417 - Proposed Amendment of Class D and Class E Airspace; Lewiston, ID

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-21

... Class E airspace extending upward from 700 feet above the surface and 1,200 feet above the surface, and...,200 feet above the surface area to enhance safety in the Lewiston-Nez Pearce County Airport, Lewiston... extending upward from 700 feet above the surface at Lewiston-Nez Perce County Airport, Lewiston, ID (77 FR...

Multiple magnetization steps and plateaus across the antiferromagnetic to ferromagnetic transition in L a1 -xC exF e12B6 : Time delay of the metamagnetic transitions

NASA Astrophysics Data System (ADS)

Diop, L. V. B.; Isnard, O.

2018-01-01

The effects of cerium substitution on the structural and magnetic properties of the L a1 -xC exF e12B6 (0 ≤x ≤0.175 ) series of compounds have been studied. All of the compounds exhibit an antiferromagnetic ground state below the Néel temperature TN≈36 K . Both antiferromagnetic and paramagnetic states can be transformed into the ferromagnetic state irreversibly and reversibly depending on the magnitude of the applied magnetic field, the temperature, and the direction of their changes. Of particular interest is the low-temperature magnetization process. This process is discontinuous and evolves unexpected huge metamagnetic transitions consisting of a succession of sharp magnetization steps separated by plateaus, giving rise to an unusual avalanchelike behavior. At constant temperature and magnetic field, the evolution with time of the magnetization displays a spectacular spontaneous jump after a long incubation time. L a1 -xC exF e12B6 compounds exhibit a unique combination of exceptional features like large thermal hysteresis, giant magnetization jumps, and remarkably huge magnetic hysteresis for the field-induced first-order metamagnetic transition.

Word Frequency Analysis MOS: 15E. Skill Levels 1 and 2.

DTIC Science & Technology

1982-05-01

AR 34 ARE I I AREA1 L 5 15 ARM 1 .: 𔃻A’FNT 3 AROL D 25 AS 12 ASSEI 3LE 12 ASSEPALED11 iES b8 ASSEMBLY 4 ASSISTA CE27 ASSISTANT13 1’A T . SSISTED 29 ...CABLE31 CA3Lr.P 2, C.ABLES . . 1 L.BLI"IG I CAM C>; 4 CA’"UT 2 CANvA S 29 CAP2 CYPSCRE ,S 4 CAPTIVE A , L I AR o,7 CAREFiULLY .... CARRY IG 2 LA.TELL 1...1 (l. 5 1 jS I E (f r I FR I 5 IP E V PEET ~ (F I 4 3 E X P N A WL S q 6 XPL11S VE E EXPIUSIVS I z~ SE 17 *.!GU I 5 EXTE nrEC 3 WI’S1. lltj 3 29 ~Il

Structural Transition and Electrical Properties of (1 - x)(Na0.4K0.1Bi0.5)TiO3- xSrTiO3 Lead-Free Piezoceramics

NASA Astrophysics Data System (ADS)

Liu, Xing; Zhai, Jiwei; Shen, Bo; Li, Feng; Li, Peng

2017-10-01

(1 - x)(Na0.4K0.1Bi0.5)TiO3- xSrTiO3 (NKBT- xST) ceramics with x = 0 mol.%, 3 mol.%, and 5 mol.% (0ST, 3ST, and 5ST) have been prepared by a conventional solid-state reaction method and their ferroelectric, electrostrictive, and pyroelectric properties investigated. Addition of ST considerably disrupted the long-range ferroelectric order of NKBT- xST ceramics, and the 5ST ceramic exhibited ergodic relaxor phase structure. T FR shifted to near or below room temperature for 5ST ceramic, accompanied by a significant decline of ferroelectricity and enhanced strain. As the temperature approached T FR, the NKBT- xST ceramics exhibited predominantly electrostrictive effect, and the 5ST ceramic presented relatively high electrostrictive coefficient Q 33 of 0.0193 m4/C2. High pyroelectric response was observed for 0ST, 3ST, and 5ST ceramics in the vicinity of T FR due to the large polarization release during the ferroelectric-relaxor structural transition. The 5ST ceramic exhibited high and frequency-insensitive (100 Hz to 10 kHz) room-temperature pyroelectric properties with pyroelectric coefficient p of 656 μC m-2 K-1 and figures of merit F i, F v, and F d reaching 233 pm/V, 0.013 m2/C, and 7.61 μPa-1/2, respectively, indicating that 5ST ceramic is a promising candidate to replace PZT-based ceramics.

Disruption of the G1/S Transition in Human Papillomavirus Type 16 E7-Expressing Human Cells Is Associated with Altered Regulation of Cyclin E

PubMed Central

Martin, Larry G.; Demers, G. William; Galloway, Denise A.

1998-01-01

The development of neoplasia frequently involves inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways and disruption of cell cycle checkpoints that monitor the integrity of replication and cell division. The human papillomavirus type 16 (HPV-16) oncoproteins, E6 and E7, have been shown to bind p53 and Rb, respectively. To further delineate the mechanisms by which E6 and E7 affect cell cycle control, we examined various aspects of the cell cycle machinery. The low-risk HPV-6 E6 and E7 proteins did not cause any significant change in the levels of cell cycle proteins analyzed. HPV-16 E6 resulted in very low levels of p53 and p21 and globally elevated cyclin-dependent kinase (CDK) activity. In contrast, HPV-16 E7 had a profound effect on several aspects of the cell cycle machinery. A number of cyclins and CDKs were elevated, and despite the elevation of the levels of at least two CDK inhibitors, p21 and p16, CDK activity was globally increased. Most strikingly, cyclin E expression was deregulated both transcriptionally and posttranscriptionally and persisted at high levels in S and G2/M. Transit through G1 was shortened by the premature activation of cyclin E-associated kinase activity. Elevation of cyclin E levels required both the CR1 and CR2 domains of E7. These data suggest that cyclin E may be a critical target of HPV-16 E7 in the disruption of G1/S cell cycle progression and that the ability of E7 to regulate cyclin E involves activities in addition to the release of E2F. PMID:9444990

Emergence and Phase Transitions

NASA Astrophysics Data System (ADS)

Sikkema, Arnold

2006-05-01

Phase transitions are well defined in physics through concepts such as spontaneous symmetry breaking, order parameter, entropy, and critical exponents. But emergence --- also exhibiting whole-part relations (such as top-down influence), unpredictability, and insensitivity to microscopic detail --- is a loosely-defined concept being used in many disciplines, particularly in psychology, biology, philosophy, as well as in physics[1,2]. I will review the concepts of emergence as used in the various fields and consider the extent to which the methods of phase transitions can clarify the usefulness of the concept of emergence both within the discipline of physics and beyond.1. Robert B. Laughlin, A Different Universe: Reinventing Physics from the Bottom Down (New York: Basic Books, 2005). 2. George F.R. Ellis, ``Physics and the Real World'', Physics Today, vol. 58, no. 7 (July 2005) pp. 49-54.

Hadronic Transitions from Upsilon (2S) to Upsilon (1s) and Upsilon Dipion Transitions at Energies Near the Upsilon (4S)

NASA Astrophysics Data System (ADS)

Kotoy, Sergei Anatolievich

This dissertation consists of two closely related analyses, both of which were performed using data collected with the CLEO II detector at the Cornell Electron Storage Ring. In the first analysis, using the world largest data sample of Υ(2 S) events, we have investigated the hadronic transitions between the Υ(2S) and the Υ(1S), i.e. decays of the Υ(2S) into the Υ(1S), plus a pair of pions ( p+p- or p0p0 ), a single η or a single p0 . The dipion transitions U(2S)-->U( 1S)pp were studied most closely, by using two different techniques: ``exclusive'' and ``inclusive''. In these measurements we determine the U(2S)-->U( 1S)pp branching ratios, and, by combining the exclusive and inclusive results, we derive the Υ(1S), leptonic branching ratios Bee and Bmm . Parameters of the ππ system in the dipion transitions (dipion invariant mass spectra, angular distributions) were analyzed and found to be consistent with current theoretical models. Lastly, we searched for the η and single π0 transitions and obtained upper limits on the branching ratios B(U(2S) -->U(1S)h ) and B(U(2S) -->U(1S)p 0) . In the second analysis, the data collected at the center of mass energies near the Υ(4S) were used to search for the dipion transition between pairs of Υ resonances. As a result of this search, we established upper limits on the branching ratios of the dipion transitions post='par'>p+p- and U(4S)-->U( 1S)p+p- , and measured the cross-sections for the radiative production of Υ(3 S) and Υ(2S) resonances e+e--->U(nS) g at the center of mass energies of Ecm = 10.58 GeV and Ecm = 10.52 GeV.

76 FR 13505 - Amendment of Class E Airspace; La Porte, IN

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010-1030; Airspace Docket No. 10-AGL-18] Amendment of Class E Airspace; La Porte, IN AGENCY: Federal... amending Class E airspace in the La Porte, IN area (76 FR 5471), Docket No. FAA-2010-1030. Subsequent to...

The nuclear structure of 223Fr

NASA Astrophysics Data System (ADS)

Kurcewicz, W.; Løvhøiden, G.; Thorsteinsen, T. F.; Borge, M. J. G.; Burke, D. G.; Cronqvist, M.; Gabelmann, H.; Gietz, H.; Hill, P.; Kaffrell, N.; Naumann, R. A.; Nybø, K.; Nyman, G.; Rogowski, J.; Isolde Collaboration

1992-03-01

The γ-rays following the β- decay of 223Rn have been investigated by means of γ-ray singles including multispectrum analysis, and γγ-coincidence measurements using Ge detectors. Multipolarities of 38 transitions in 223Fr have been established by measuring conversion electrons with a mini-orange electron spectrometer. Most of the observed transitions could be placed in a level scheme comprising 53 excited states of 223Fr. The level structure is interpreted in terms of K π = {3}/{2}± and {1}/{2}± parity doublet bands, and a second K π = {3}/{2}± higher-lying parity doublet. The experimental data are compared with the theoretical predictions of the reflection-asymmetric rotor model.

High field induced magnetic transitions in the Y0.7E r0.3F e2D4.2 deuteride

NASA Astrophysics Data System (ADS)

Paul-Boncour, V.; Guillot, M.; Isnard, O.; Hoser, A.

2017-09-01

The influence of the partial Er for Y substitution on the crystal structure and magnetic properties of YF e2D4.2 has been investigated by high field magnetization and neutron diffraction experiments. Y0.7E r0.3F e2D4.2 compound crystallizes in the same monoclinic structure as YF e2D4.2 described in P c (P1c1) space group with D atoms located in 18 different tetrahedral interstitial sites. A cell volume contraction of 0.6% is observed upon Er substitution, inducing large modification of the magnetic properties. Electronic effect of D insertion as well as lowering of crystal symmetry are important factors determining the magnetic properties of Fe sublattice, which evolves towards more delocalized behavior and modifying the Er-Fe exchange interactions. In the ground state, the Er and Fe moments are arranged ferrimagnetically within the plane perpendicular to the monoclinic b axis and with average moments mEr=6.4 (3 ) μBEr-1 and mFe=2.0 (1 ) μBFe-1 at 10 K. Upon heating, mEr decreases progressively until TEr=55 K . Between 55 K and 75 K, the Fe sublattice undergoes a first-order ferromagnetic-antiferromagnetic (FM-AFM) transition with a cell volume contraction due to the itinerant metamagnetic behavior of one Fe site. In the AFM structure, mFe decreases until the Néel temperature TN=125 K . At high field, two different types of field induced transitions are observed. The Er moments become parallel to the Fe one and saturates to the E r3 + free ion value, leading to an unusual field induced FM arrangement at a transition field BTrans of only 78 kG below 30 K. Then above TM0=66 K , an AFM-FM transition of the Fe sublattice, accompanied by a cell volume increase is observed. BTrans increases linearly versus temperature and with a larger d BTrans/d T slope than for YF e2D4.2 . This has been explained by the additional contribution of Er induced moments above BTrans.

78 FR 5128 - Amendment of Class E Airspace; Savoonga, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

...-0323; Airspace Docket No. 12-AAL-4] Amendment of Class E Airspace; Savoonga, AK AGENCY: Federal... Savoonga, AK, to accommodate aircraft using Area Navigation (RNAV) Global Positioning System (GPS) standard... modify controlled airspace at Savoonga, AK (77 FR 61304). Interested parties were invited to participate...

Open charm contributions to the E1 transitions of ψ (3686) and ψ (3770)→ γ χ _{cJ}

NASA Astrophysics Data System (ADS)

Cao, Zheng; Cleven, Martin; Wang, Qian; Zhao, Qiang

2016-11-01

The E1 transitions of ψ (3686) and ψ (3770)→ γ χ _{cJ} are investigated in a non-relativistic effective field theory (NREFT) where the open charm effects are included systematically as the leading corrections. It also allows a self-consistent inclusion of the S-D mixing in the same framework. We are able to show that the open charm contributions are essential for understanding the rather unexpected discrepancies between the non-relativistic leading order calculations and the experimental data for these two low-lying states.

Study of phase transition of even and odd nuclei based on q-deforme SU(1,1) algebraic model

NASA Astrophysics Data System (ADS)

Jafarizadeh, M. A.; Amiri, N.; Fouladi, N.; Ghapanvari, M.; Ranjbar, Z.

2018-04-01

The q-deformed Hamiltonian for the SO (6) ↔ U (5) transitional case in s, d interaction boson model (IBM) can be constructed by using affine SUq (1 , 1) Lie algebra in the both IBM-1 and 2 versions and IBFM. In this research paper, we have studied the energy spectra of 120-128Xe isotopes and 123-131Xe isotopes and B(E2) transition probabilities of 120-128Xe isotopes in the shape phase transition region between the spherical and gamma unstable deformed shapes of the theory of quantum deformation. The theoretical results agree with the experimental data fairly well. It is shown that the q-deformed SO (6) ↔ U (5) transitional dynamical symmetry remains after deformation.

Ab initio computation of the transition temperature of the charge density wave transition in TiS e2

NASA Astrophysics Data System (ADS)

Duong, Dinh Loc; Burghard, Marko; Schön, J. Christian

2015-12-01

We present a density functional perturbation theory approach to estimate the transition temperature of the charge density wave transition of TiS e2 . The softening of the phonon mode at the L point where in TiS e2 a giant Kohn anomaly occurs, and the energy difference between the normal and distorted phase are analyzed. Both features are studied as functions of the electronic temperature, which corresponds to the Fermi-Dirac distribution smearing value in the calculation. The transition temperature is found to be 500 and 600 K by phonon and energy analysis, respectively, in reasonable agreement with the experimental value of 200 K.

Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

PubMed

Shyu, Yu-Chiau; Lee, Tung-Liang; Chen, Xin; Hsu, Pang-Hung; Wen, Shau-Ching; Liaw, Yi-Wei; Lu, Chi-Huan; Hsu, Po-Yen; Lu, Mu-Jie; Hwang, JauLang; Tsai, Ming-Daw; Hwang, Ming-Jing; Chen, Jim-Ray; Shen, Che-Kun James

2014-02-24

Erythropoiesis is a highly regulated process during which BFU-E are differentiated into RBCs through CFU-E, Pro-E, PolyCh-E, OrthoCh-E, and reticulocyte stages. Uniquely, most erythroid-specific genes are activated during the Pro-E to Baso-E transition. We show that a wave of nuclear import of the erythroid-specific transcription factor EKLF occurs during the Pro-E to Baso-E transition. We further demonstrate that this wave results from a series of finely tuned events, including timed activation of PKCθ, phosphorylation of EKLF at S68 by P-PKCθ(S676), and sumoylation of EKLF at K74. The latter EKLF modifications modulate its interactions with a cytoplasmic ankyrin-repeat-protein FOE and importinβ1, respectively. The role of FOE in the control of EKLF nuclear import is further supported by analysis of the subcellular distribution patterns of EKLF in FOE-knockout mice. This study reveals the regulatory mechanisms of the nuclear import of EKLF, which may also be utilized in the nuclear import of other factors. Copyright © 2014 Elsevier Inc. All rights reserved.

75 FR 63708 - Establishment of Class E Airspace; Kalaupapa, HI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

...-0650; Airspace Docket No. 10-AWP-9] Establishment of Class E Airspace; Kalaupapa, HI AGENCY: Federal... airspace at Kalaupapa, HI, to accommodate aircraft using a new Area Navigation (RNAV) Global Positioning... Register a notice of proposed rulemaking to establish controlled airspace at Kalaupapa, HI (75 FR 49868...

76 FR 18041 - Establishment of Class E Airspace; Kahului, HI

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

...-1233; Airspace Docket No. 10-AWP-21] Establishment of Class E Airspace; Kahului, HI AGENCY: Federal... airspace at Kahului Airport, Kahului, HI, to accommodate aircraft using Area Navigation (RNAV) standard... establish controlled airspace at Kahului, HI (76 FR 3571). Interested parties were invited to participate in...

78 FR 8962 - Establishment of Class E Airspace; Kasigluk, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-07

...-0952; Airspace Docket No. 12-AAL-6] Establishment of Class E Airspace; Kasigluk, AK AGENCY: Federal... at Kasigluk, AK, to accommodate aircraft using Area Navigation (RNAV) Global Positioning System (GPS... rulemaking to modify controlled airspace at Kasigluk, AK (77 FR 60660). Interested parties were invited to...

78 FR 45849 - Amendment of Class E Airspace; Gustavus, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

...-0282; Airspace Docket No. 13-AAL-3] Amendment of Class E Airspace; Gustavus, AK AGENCY: Federal... Gustavus Airport, Gustavus, AK. Decommissioning of the Gustavus Nondirectional Radio Beacon (NDB) has made... Register a notice of proposed rulemaking (NPRM) to amend controlled airspace at Gustavus, AK (78 FR 31871...

77 FR 6 - Amendment of Class E Airspace; Kwigillingok, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-03

...-0881; Airspace Docket No. 11-AAL-18] Amendment of Class E Airspace; Kwigillingok, AK AGENCY: Federal... Kwigillingok, AK. The revision of two standard instrument approach procedures at the Kwigillingok Airport has... airspace at Kwigillingok, AK (76 FR 54151). Interested parties were invited to participate in this...

Collisional perturbation of radio-frequency E1 transitions in an atomic beam of dysprosium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cingoez, A.; Lapierre, Alain; Nguyen, A.-T.

2005-12-15

We have studied collisional perturbations of radio-frequency (rf) electric-dipole (E1) transitions between the nearly degenerate opposite-parity levels in atomic dysprosium (Dy) in the presence of 10 to 80 {mu}Torr of H{sub 2}, N{sub 2}, He, Ar, Ne, Kr, and Xe. Collisional broadening and shift of the resonance, as well as the attenuation of the signal amplitude are observed to be proportional to the foreign-gas density with the exception of H{sub 2} and Ne, for which no shifts were observed. Corresponding rates and cross sections are presented. In addition, rates and cross sections for O{sub 2} are extracted from measurements usingmore » air as foreign gas. The primary motivation for this study is the need for accurate determination of the shift rates, which are needed in a laboratory search for the temporal variation of the fine-structure constant [A. T. Nguyen, D. Budker, S. K. Lamoreaux, and J. R. Torgerson, Phys. Rev. A 69, 22105 (2004)].« less

Energy spectra and E2 transition rates of 124—130Ba

NASA Astrophysics Data System (ADS)

Sabri, H.; Seidi, M.

2016-10-01

In this paper, we have studied the energy spectra and B(E2) values of 124—130Ba isotopes in the shape phase transition region between the spherical and gamma unstable deformed shapes. We have used a transitional interacting Boson model (IBM), Hamiltonian which is based on affine SU(1,1) Lie algebra in the both IBM-1 and 2 versions and also the Catastrophe theory in combination with a coherent state formalism to generate energy surfaces and determine the exact values of control parameters. Our results for control parameters suggest a combination of U(5) and SO(6) dynamical symmetries in this isotopic chain. Also, the theoretical predictions can be rather well reproduce the experimental counterparts, when the control parameter is approached to the SO(6) limit.

75 FR 17851 - Amendment of Class E Airspace; Dallas-Fort Worth, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

...-0926; Airspace Docket No. 09-ASW-26] Amendment of Class E Airspace; Dallas-Fort Worth, TX AGENCY... airspace in the Dallas-Fort Worth, TX area. Additional controlled airspace is necessary to accommodate new... proposed rulemaking to amend Class E airspace for the Dallas- Fort Worth, TX area (74 FR 57617) Docket No...

E-H heating mode transition in inductive discharges with different antenna sizes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Hyo-Chang, E-mail: flower4507@hanyang.ac.kr; Chung, Chin-Wook, E-mail: joykang@hanyang.ac.kr

The spatial distribution of plasma density and the transition power for capacitive (E) to inductive (H) mode transition are studied in planar type inductively coupled plasmas with different antenna sizes. The spatial plasma distribution has a relatively flat profile at a low gas pressure, while the plasma profile is affected by the antenna size at higher gas pressure. The transition power for the E to H mode transition is shown to be critically affected by the antenna size. When the discharge is sustained by a small one-turn antenna coil, the transition power has a minimum value at Ar gas ofmore » 20 mTorr. However, the minimum transition power is shown at a relatively high gas pressure (40–60 mTorr) in the case of a large one-turn antenna coil. This change in the transition power can be understood by the thermal transport of the energetic electrons with non-local kinetics to the chamber wall. This non-local kinetic effect indicates that the transition power can also increase even for a small antenna if the antenna is placed near the wall.« less

Photon transitions in {psi}(2S) decays to {chi}{sub cJ}(1P) and {eta}{sub c}(1S)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Athar, S.B.; Avery, P.; Breva-Newell, L.

2004-12-01

We have studied the inclusive photon spectrum in {psi}(2S) decays using the CLEO III detector. We present the most precise measurements of electric dipole (E1) photon transition rates for {psi}(2S){yields}{gamma}{chi}{sub cJ}(1P) (J=0,1,2). We also confirm the hindered magnetic dipole (M1) transition, {psi}(2S){yields}{gamma}{eta}{sub c}(1S). However, the direct M1 transition {psi}(2S){yields}{gamma}{eta}{sub c}(2S) observed by the Crystal Ball as a narrow peak at a photon energy of 91 MeV is not found in our data.

Transition State Gauche Effects Control the Torquoselectivities of the Electrocyclizations of Chiral 1-Azatrienes.

PubMed

Patel, Ashay; Vella, Joseph R; Ma, Zhi-Xiong; Hsung, R P; Houk, K N

2015-12-04

Hsung et al. have reported a series of torquoselective electrocyclizations of chiral 1-azahexa-1E,3Z,5E-trienes that yield functionalized dihydropyridines. To understand the origins of the torquoselectivities of these azaelectrocyclizations, we modeled these electrocyclic ring closures using the M06-2X density functional. A new stereochemical model that rationalizes the observed 1,2 stereoinduction emerges from these computations. This model is an improvement and generalization of the "inside-alkoxy" model used to rationalize stereoselectivities of the 1,3-dipolar cycloaddition of chiral allyl ethers and emphasizes a stabilizing hyperconjugative effect, which we have termed a transition state gauche effect. This stereoelectronic effect controls the conformational preferences at the electrocyclization transition states, and only in one of the allowed disrotatory electrocyclization transition states is the ideal stereoelectronic arrangement achieved without the introduction of a steric clash. Computational experiments confirm the role of this effect as a stereodeterminant since substrates with electropositive groups and electronegative groups have different conformational preferences at the transition state and undergo ring closure with divergent stereochemical outcomes. This predicted reversal of stereoselectivity for the ring closures of several silyl substituted azatrienes have been demonstrated experimentally.

Multiplet exchange Auger transitions following resonant Auger decays in Ne 1s photoexcitation

NASA Astrophysics Data System (ADS)

Tamenori, Yusuke; Suzuki, Isao H.

2014-07-01

Secondary electron emission with very low kinetic energy (KE) has been measured in the Ne 1s photoexcitation region. A new decay channel for Auger transitions following Ne 1s to 3p excitation has been identified using a two-dimensional mapping technique, in which slow Auger electron signals are displayed as functions of electron kinetic energy and photon energy. Electrons with about 0.68 eV KEs have been ascribed to multiplet exchange Auger electrons from the 2p-2(1S)3d state. This state is formed through the resonant Auger transition from the 1s-13p state, in which the excited 3p electron changes its azimuthal quantum number. Another cascade Auger decay of multiplet exchanging was found as electron emission of about 2.0 eV KEs; 2p-2(1S)4p → 2p-2(3P) + e-. Several cascade decays were found to occur via the photoexcitation into 1s-14p and 1s-15p states.

77 FR 30187 - Amendment of Class E Airspace; Rock Springs, WY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

...-0131; Airspace Docket No. 12-ANM-2] Amendment of Class E Airspace; Rock Springs, WY AGENCY: Federal... Rock Springs-Sweetwater County Airport, Rock Springs, WY. Decommissioning of the Rock Springs Tactical... Rock Springs, WY (77 FR 11796). Interested parties were invited to participate in this rulemaking...

78 FR 59806 - Establishment of Class E Airspace; White Mountain, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

...-1185; Airspace Docket No. 12-AAL-8] Establishment of Class E Airspace; White Mountain, AK AGENCY... airspace at White Mountain Airport, White Mountain, AK, to accommodate aircraft using new Area Navigation..., Airport, White Mountain, AK (77 FR 75598). Interested parties were invited to participate in this...

77 FR 9840 - Amendment of Class E Airspace; Colorado Springs, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

...-1191; Airspace Docket No. 11-ANM-21] Amendment of Class E Airspace; Colorado Springs, CO AGENCY... airspace at City of Colorado Springs Municipal Airport, Colorado Springs, CO. Decommissioning of the Black... controlled airspace at Colorado Springs, CO (76 FR 70920). Interested parties were invited to participate in...

75 FR 18402 - Amendment of Class E Airspace; North Bend, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

...-0831; Airspace Docket No. 09-ANM-13] Amendment of Class E Airspace; North Bend, OR AGENCY: Federal... at Southwest Oregon Regional Airport, North Bend, OR, to allow aircraft at Sunnyhill Airport to... rulemaking to establish additional controlled airspace at North Bend, OR (74 FR 57616). Interested parties...

77 FR 5169 - Amendment of Class E Airspace; South Bend, IN

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

...-0250; Airspace Docket No. 11-AGL-6] Amendment of Class E Airspace; South Bend, IN AGENCY: Federal... South Bend, IN, area. Additional controlled airspace is necessary to accommodate new Area Navigation... South Bend, IN, area, creating additional controlled airspace at Jerry Tyler Memorial Airport (76 FR...

Radiative rates for E1, E2, M1, and M2 transitions in the Br-like ions Sr IV, Y V, Zr VI, Nb VII, and Mo VIII

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aggarwal, Kanti M., E-mail: K.Aggarwal@qub.ac.uk; Keenan, Francis P.

Energies and lifetimes are reported for the lowest 375 levels of five Br-like ions, namely Sr IV, Y V, Zr VI, Nb VII, and Mo VIII, mostly belonging to the 4s{sup 2}4p{sup 5}, 4s{sup 2}4p{sup 4}4ℓ, 4s4p{sup 6}, 4s{sup 2}4p{sup 4}5ℓ, 4s{sup 2}4p{sup 3}4d{sup 2}, 4s4p{sup 5}4ℓ, and 4s4p{sup 5}5ℓ configurations. Extensive configuration interaction has been included and the general-purpose relativistic atomic structure package (GRASP) has been adopted for the calculations. Additionally, radiative rates are listed among these levels for all E1, E2, M1, and M2 transitions. From a comparison with the measurements, the majority of our energy levels are assessed to be accurate tomore » better than 2%, although discrepancies between theory and experiment for a few are up to 6%. An accuracy assessment of the calculated radiative rates (and lifetimes) is more difficult, because no prior results exist for these ions.« less

Inelastic e+Mg collision data and its impact on modelling stellar and supernova spectra

NASA Astrophysics Data System (ADS)

Barklem, P. S.; Osorio, Y.; Fursa, D. V.; Bray, I.; Zatsarinny, O.; Bartschat, K.; Jerkstrand, A.

2017-09-01

Results of calculations for inelastic e+Mg effective collision strengths for the lowest 25 physical states of Mg I (up to 3s6p1P), and thus 300 transitions, from the convergent close-coupling (CCC) and the B-spline R-matrix (BSR) methods are presented. At temperatures of interest, 5000 K, the results of the two calculations differ on average by only 4%, with a scatter of 27%. As the methods are independent, this suggests that the calculations provide datasets for e+Mg collisions accurate to this level. Comparison with the commonly used dataset compiled by Mauas et al. (1988, ApJ, 330, 1008), covering 25 transitions among 12 states, suggests the Mauas et al. data are on average 57% too low, and with a very large scatter of a factor of 6.5. In particular the collision strength for the transition corresponding to the Mg I intercombination line at 457 nm is significantly underestimated by Mauas et al., which has consequences for models that employ this dataset. In giant stars the new data leads to a stronger line compared to previous non-LTE calculations, and thus a reduction in the non-LTE abundance correction by 0.1 dex ( 25%). A non-LTE calculation in a supernova ejecta model shows this line becomes significantly stronger, by a factor of around two, alleviating the discrepancy where the 457 nm line in typical models with Mg/O ratios close to solar tended to be too weak compared to observations. Full Tables 2 and 3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/606/A11

76 FR 5471 - Amendment of Class E Airspace; La Porte, IN

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010-1030; Airspace Docket No. 10-AGL-18] Amendment of Class E Airspace; La Porte, IN AGENCY: Federal... controlled airspace at La Porte Hospital Heliport (75 FR 68556) Docket No. FAA-2010-1030. Interested parties...

76 FR 57633 - Amendment of Class E Airspace; Miles City, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

...-0515; Airspace Docket No. 11-ANM-11] Amendment of Class E Airspace; Miles City, MT AGENCY: Federal... Miles City, MT, to accommodate aircraft using a new Area Navigation (RNAV) Global Positioning System... proposed rulemaking to modify controlled airspace at Miles City, MT (76 FR 41725). Interested parties were...

77 FR 6 - Amendment of Class E Airspace; Galbraith Lake, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-03

...-0865; Airspace Docket No. 11-AAL-14] Amendment of Class E Airspace; Galbraith Lake, AK AGENCY: Federal... Galbraith Lake, AK. The creation of two standard instrument approach procedures at the Galbraith Lake... airspace at Galbraith Lake, AK (76 FR 54152). Interested parties were invited to participate in this...

Induction of DREB2A pathway with repression of E2F, jasmonic acid biosynthetic and photosynthesis pathways in cold acclimation-specific freeze-resistant wheat crown.

PubMed

Karki, Amrit; Horvath, David P; Sutton, Fedora

2013-03-01

Winter wheat lines can achieve cold acclimation (development of tolerance to freezing temperatures) and vernalization (delay in transition from vegetative to reproductive phase) in response to low non-freezing temperatures. To describe cold-acclimation-specific processes and pathways, we utilized cold acclimation transcriptomic data from two lines varying in freeze survival but not vernalization. These lines, designated freeze-resistant (FR) and freeze-susceptible (FS), were the source of crown tissue RNA. Well-annotated differentially expressed genes (p ≤ 0.005 and fold change ≥ 2 in response to 4 weeks cold acclimation) were used for gene ontology and pathway analysis. "Abiotic stimuli" was identified as the most enriched and unique for FR. Unique to FS was "cytoplasmic components." Pathway analysis revealed the "triacylglycerol degradation" pathway as significantly downregulated and common to both FR and FS. The most enriched of FR pathways was "neighbors of DREB2A," with the highest positive median fold change. The "13-LOX and 13-HPL" and the "E2F" pathways were enriched in FR only with a negative median fold change. The "jasmonic acid biosynthesis" pathway and four "photosynthetic-associated" pathways were enriched in both FR and FS but with a more negative median fold change in FR than in FS. A pathway unique to FS was "binding partners of LHCA1," which was enriched only in FS with a significant negative median fold change. We propose that the DREB2A, E2F, jasmonic acid biosynthesis, and photosynthetic pathways are critical for discrimination between cold-acclimated lines varying in freeze survival.

NG9-1-1 transition issues report.

DOT National Transportation Integrated Search

2008-02-01

A key outcome of the U.S. Department of Transportation (USDOT) Next Generation 9-1-1 : (NG9-1-1) Initiative is the identification of well-supported options and crucial transition issues : for migrating from todays 9-1-1 system to a NG9-1-1 system ...

WASP-42 b and WASP-49 b: two new transiting sub-Jupiters

NASA Astrophysics Data System (ADS)

Lendl, M.; Anderson, D. R.; Collier-Cameron, A.; Doyle, A. P.; Gillon, M.; Hellier, C.; Jehin, E.; Lister, T. A.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Smalley, B.; Ségransan, D.; Smith, A. M. S.; Triaud, A. H. M. J.; Udry, S.; West, R. G.; Wheatley, P. J.

2012-08-01

We report the discovery of two new transiting planets from the WASP survey. WASP-42 b is a 0.500 ± 0.035 MJ planet orbiting a K1 star at a separation of 0.0548 ± 0.0017 AU with a period of 4.9816872 ± 7.3 × 10-6 days. The radius of WASP-42 b is 1.080 ± 0.057 RJ while its equilibrium temperature is Teq = 995 ± 34 K. We detect some evidence for a small but non-zero eccentricity of e = 0.060 ± 0.013. WASP-49 b is a 0.378 ± 0.027 MJ planet around an old G6 star. It has a period of 2.7817387 ± 5.6 × 10-6 days and a separation of 0.0379 ± 0.0011 AU. This planet is slightly bloated, having a radius of 1.115 ± 0.047 RJ and an equilibrium temperature of Teq = 1369 ± 39 K. Both planets have been followed up photometrically, and in total we have obtained 5 full and one partial transit light curves of WASP-42 and 4 full and one partial light curves of WASP-49 using the Euler-Swiss, TRAPPIST and Faulkes South telescopes. Based on photometric observations made with WASP-South, EulerCam on the Euler-Swiss telescope, the Belgian TRAPPIST telescope, the Faulkes South Telescope and spectroscopic observations obtained with CORALIE on the Euler-Swiss telescope and HARPS on the ESO 3.6 m telescope (Prog. ID: 087.C-0649).The photometric time series and radial velocity data in this work are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/544/A72

Upper limit for the D2H+ ortho-to-para ratio in the prestellar core 16293E (CHESS)

NASA Astrophysics Data System (ADS)

Vastel, C.; Caselli, P.; Ceccarelli, C.; Bacmann, A.; Lis, D. C.; Caux, E.; Codella, C.; Beckwith, J. A.; Ridley, T.

2012-11-01

The H_3^+ ion plays a key role in the chemistry of dense interstellar gas clouds where stars and planets are forming. The low temperatures and high extinctions of such clouds make direct observations of H_3^+ impossible, but lead to large abundances of H2D+ and D2H+, which are very useful probes of the early stages of star and planet formation. The ground-state rotational ortho-D2H+ 11,1-00,0 transition at 1476.6 GHz in the prestellar core 16293E has been searched for with the Herschel HIFI instrument, within the CHESS (Chemical HErschel Surveys of Star forming regions) Key Program. The line has not been detected at the 21 mK km s-1 level (3σ integrated line intensity). We used the ortho-H2D+ 11,0-11,1 transition and para-D2H+ 11,0-10,1 transition detected in this source to determine an upper limit on the ortho-to-para D2H+ ratio as well as the para-D2H+/ortho-H2D+ ratio from a non-local thermodynamic equilibrium analysis. The comparison between our chemical modeling and the observations suggests that the CO depletion must be high (larger than 100), with a density between 5 × 105 and 106 cm-3. Also the upper limit on the ortho-D2H+ line is consistent with a low gas temperature (~11 K) with a ortho-to-para ratio of 6 to 9, i.e. 2 to 3 times higher than the value estimated from the chemical modeling, making it impossible to detect this high frequency transition with the present state of the art receivers. The chemical network is only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/547/A33Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.

77 FR 43536 - Wireless E911 Phase II Location Accuracy Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-25

... Docket No. 07-114; FCC 11-107] Wireless E911 Phase II Location Accuracy Requirements AGENCY: Federal...- 2413, or email: [email protected]fcc.gov . SUPPLEMENTARY INFORMATION: This document announces that, on... Commission's Order, FCC 11-107, published at 76 FR 59916, September 28, 2011. The OMB Control Number is 3060...

78 FR 17083 - Amendment of Class E Airspace; Scammon Bay, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-20

...-0121; Airspace Docket No. 12-AAL-2] Amendment of Class E Airspace; Scammon Bay, AK AGENCY: Federal... Scammon Bay Airport, Scammon Bay, AK. Controlled airspace is necessary to accommodate aircraft using a new... Federal Register a notice of proposed rulemaking to modify controlled airspace at Scammon Bay, AK (77 FR...

75 FR 3984 - Establishment of Class D and Class E Airspace, Modification of Class E Airspace; Ocala, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

... airspace at Ocala International Airport-Jim Taylor Field, Ocala, FL. This action also makes a minor... International Airport--Jim Taylor Field, Ocala, FL, published in the Federal Register June 24, 2009 (74 FR 29939... radius in the Class E5 description for Ocala International Airport--Jim Taylor Field was stated...

The B(E2;4^+1->2^+1) / B(E2;2^+1->0^+1) Ratio in Even-Even Nuclei

NASA Astrophysics Data System (ADS)

Loelius, C.; Sharon, Y. Y.; Zamick, L.; G"Urdal, G.

2009-10-01

We considered 207 even-even nuclei throughout the chart of nuclides for which the NNDC Tables had data on the energies and lifetimes of the 2^+1 and 4^+1 states. Using these data we calculated for each nucleus the electric quadrupole transition strengths B(E2;4^+1->2^+1) and B(E2;2^+1->0^+1), as well as their ratio. The internal conversion coefficients were obtained by using the NNDC HSICC calculator. For each nucleus we plotted the B(E2) ratio against A, N, and Z. We found that for close to 90% of the nuclei considered the ratio had values between 0.5 and 2.5. Most of the outliers had magic numbers of protons or neutrons. Our ratio results were compared with the theoretical predictions for this ratio by different models--10/7 in the rotational model and 2 in the simplest vibrational model. In the rotational regions (for 150 < A < 180 and A > 220) the ratios were indeed close to 10/7. For the few nuclei thought to be vibrational the ratios were usually less than 2. Otherwise, we got a wide scatter of ratio values. Hence other models, including the NpNn scheme, must be considered in interpreting these results.

77 FR 45239 - Amendment of Class E Airspace; Bar Harbor, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

...-1366; Airspace Docket No. 11-ANE-13] Amendment of Class E Airspace; Bar Harbor, ME AGENCY: Federal... area at Bar Harbor, ME, as the Surry Non-Directional Radio Beacon (NDB) has been decommissioned and new... airspace at Bar Harbor, ME (77 FR 27666) Docket No. FAA-2011-1366. Interested parties were invited to...

Infrared study of transitional disks in Ophiuchus with Herschel

NASA Astrophysics Data System (ADS)

Rebollido, Isabel; Merín, Bruno; Ribas, Álvaro; Bustamante, Ignacio; Bouy, Hervé; Riviere-Marichalar, Pablo; Prusti, Timo; Pilbratt, Göran L.; André, Philippe; Ábrahám, Péter

2015-09-01

Context. Observations of nearby star-forming regions with the Herschel Space Observatory complement our view of the protoplanetary disks in Ophiuchus with information about the outer disks. Aims: The main goal of this project is to provide new far-infrared fluxes for the known disks in the core region of Ophiuchus and to identify potential transitional disks using data from Herschel. Methods: We obtained PACS and SPIRE photometry of previously spectroscopically confirmed young stellar objects (YSO) in the region and analysed their spectral energy distributions. Results: From an initial sample of 261 objects with spectral types in Ophiuchus, we detect 49 disks in at least one Herschel band. We provide new far-infrared fluxes for these objects. One of them is clearly a new transitional disk candidate. Conclusions: The data from Herschel Space Observatory provides fluxes that complement previous infrared data and that we use to identify a new transitional disk candidate. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Final reduced Herschel maps are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/581/A30Appendix A is available in electronic form at http://www.aanda.orgAll tables are also available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/581/A30

Neutronic analysis of the 1D and 1E banks reflux detection system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blanchard, A.

1999-12-21

Two H Canyon neutron monitoring systems for early detection of postulated abnormal reflux conditions in the Second Uranium Cycle 1E and 1D Mixer-Settle Banks have been designed and built. Monte Carlo neutron transport simulations using the general purpose, general geometry, n-particle MCNP code have been performed to model expected response of the monitoring systems to varying conditions.The confirmatory studies documented herein conclude that the 1E and 1D neutron monitoring systems are able to achieve adequate neutron count rates for various neutron source and detector configurations, thereby eliminating excessive integration count time. Neutron count rate sensitivity studies are also performed. Conversely,more » the transport studies concluded that the neutron count rates are statistically insensitive to nitric acid content in the aqueous region and to the transition region length. These studies conclude that the 1E and 1D neutron monitoring systems are able to predict the postulated reflux conditions for all examined perturbations in the neutron source and detector configurations. In the cases examined, the relative change in the neutron count rates due to postulated transitions from normal {sup 235}U concentration levels to reflux levels remain satisfactory detectable.« less

Highly excited symmetry-breaking infrared and THz transitions in methanol-D 1

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Indranath

2004-06-01

In this paper, symmetry-breaking transitions have been identified in the Fourier transform infrared (FTIR) and Terra Hertz (THz) fast scan spectra of asymmetrically deuterated methanol CH 2DOH involving three quanta of the lowest lying vibrational state ( ν1). These transitions have an upper state belonging to highly excited torsional state with the torsional quantum number v=11 (e 5) (with the axial component of total rotational angular momentum K=5 and 6) in the Internal Axis Method (IAM) formalism developed by Quade and his co-workers [J. Mol. Spectrosc. 146 (1991) 238; J. Mol. Spectrosc. 146 (1991) 252], which was later extended by Mukhopadhyay [Spectrochim. Acta A 53 (1997) 2457; Spectrochim. Acta A 53 (1997) 1947] to include highly excited torsional-rotational states. The originating lower states belong to the o 1 ( v=3) with K=4 and 5. In analogy with pure methanol these transitions terminate to the third excited torsional state, which has very small torsional matrix elements to be observable in normal FTIR spectra. The location of the e 5 states suggests that the calculated energy levels using the parameters of Liu and Quade [J. Mol. Spectrosc. 146 (1991) 252] are reasonable and very helpful to assign such highly excited transitions, considering that their studies include low angular momentum states. In addition the very existence of these transitions proves that the matrix elements calculated by Mukhopadhyay [Spectrochim. Acta A 53 (1997) 1947] are very useful and dependable. Thus they represent a valuable tool for entangling the complex spectrum of this asymmetrically deuterated methanol. In order to provide confirmatory evidence the THz spectra obtained using the Fast Scanning Submillimeter Spectroscopy Technique (FASSST) at the Ohio State University [Rev. Instr. 68 (1997) 1675; Anal. Chem. 70 (1998) 719A] were searched for the ground state transitions that can be calculated precisely from IR combination relations. All the transitions that can be

76 FR 56242 - Energy Northwest; Establishment of Atomic Safety and Licensing Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

... Northwest's Columbia Generating Station,'' was received via E-Filing on August 22, 2011.\\1\\ \\1\\ On August 22... with the NRC E-Filing rule, which the NRC promulgated in August 2007 (72 FR 49,139). Issued at..., 1972, published in the Federal Register, 37 FR 28,710 (1972), and the Commission's regulations, see, e...

78 FR 65208 - Modification of Class D and E Airspace; Kenai, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

...-1174; Airspace Docket No. 12-AAL-12] Modification of Class D and E Airspace; Kenai, AK AGENCY: Federal... airspace at Kenai Municipal Airport, Kenai, AK. Controlled airspace is necessary to accommodate aircraft... (NPRM) to modify controlled airspace at Kenai Municipal Airport, Kenai, AK (78 FR 34609). Interested...

76 FR 36887 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-23

... methods: Federal eRulemaking Portal: http://www.regulations.gov . Identify comments by ``Docket No. SBA... (76 FR 13532). SBA received 11 comments in Regulations.gov from a mix of small business trade organizations, a small business owner, an SBA loan program participating lender, an advocacy and research...

E2/M1 and C2/M1 at Elsa

NASA Astrophysics Data System (ADS)

Gothe, R. W.

2003-07-01

At the ELectron Stretcher Accelerator ELSA the four momentum transfer dependence of the N to Δ transition has been investigated by measuring the \\vartheta {π }{*} and \\varphi {π }{*} angular distribution of the double differential pion production cross sections in a series of electron scattering coincidence experiments on hydrogen in the -K2-range from 0.04 GeV2 to 0.8 GeV2. The azimuthal angular dependence of the hadronic cross section is based on the polarization of the virtual photon and separates the response functions RT + ∈LRL, RLT and RTT. Whereas the individual \\vartheta {π }{*} -dependences of these response functions allow to form specific ratios, which are sensitive either to the electric transverse (E2 or E1+) or the Coulomb (C2 or S1+) quadrupole transition amplitudes. Preliminary results on the extraction of such multipole ratios have been previously reported in the NSTAR 2000 proceedings1. First results for a -K2 of 0.638 GeV2 obtained after radiative and resolution dependent corrections are described here and compared to other most recent experimental results.

77 FR 16784 - E. & J. Gallo Winery; Filing of Color Additive Petition

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 73 [Docket No. FDA-2012-C-0224] E. & J. Gallo Winery; Filing of Color Additive Petition AGENCY: Food and Drug..., Acting Director, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition. [FR Doc...

31 CFR 560.406 - Transshipment or transit through United States prohibited.

Code of Federal Regulations, 2012 CFR

2012-07-01

... or transit, of Iranian-origin goods or goods owned or controlled by the Government of Iran which are... transit of foreign goods through the United States which are intended or destined for Iran or the Government of Iran, including entities owned or controlled by the Government of Iran. [64 FR 20172, Apr. 26...

31 CFR 560.406 - Transshipment or transit through United States prohibited.

Code of Federal Regulations, 2010 CFR

2010-07-01

... or transit, of Iranian-origin goods or goods owned or controlled by the Government of Iran which are... transit of foreign goods through the United States which are intended or destined for Iran or the Government of Iran, including entities owned or controlled by the Government of Iran. [64 FR 20172, Apr. 26...

31 CFR 560.406 - Transshipment or transit through United States prohibited.

Code of Federal Regulations, 2011 CFR

2011-07-01

... or transit, of Iranian-origin goods or goods owned or controlled by the Government of Iran which are... transit of foreign goods through the United States which are intended or destined for Iran or the Government of Iran, including entities owned or controlled by the Government of Iran. [64 FR 20172, Apr. 26...

40 CFR Appendix D to Subpart E of... - EPA Transition Policy-Existing Consulting Engineering Agreements

Code of Federal Regulations, 2012 CFR

2012-07-01

... Consulting Engineering Agreements D Appendix D to Subpart E of Part 35 Protection of Environment... Transition Policy—Existing Consulting Engineering Agreements a. access to records—audit 1. Access clause... access clause is included in the consulting engineering subagreement. The clause contained in appendix C...

40 CFR Appendix D to Subpart E of... - EPA Transition Policy-Existing Consulting Engineering Agreements

Code of Federal Regulations, 2013 CFR

2013-07-01

... Consulting Engineering Agreements D Appendix D to Subpart E of Part 35 Protection of Environment... Transition Policy—Existing Consulting Engineering Agreements a. access to records—audit 1. Access clause... access clause is included in the consulting engineering subagreement. The clause contained in appendix C...

40 CFR Appendix D to Subpart E of... - EPA Transition Policy-Existing Consulting Engineering Agreements

Code of Federal Regulations, 2014 CFR

2014-07-01

... Consulting Engineering Agreements D Appendix D to Subpart E of Part 35 Protection of Environment... Transition Policy—Existing Consulting Engineering Agreements a. access to records—audit 1. Access clause... access clause is included in the consulting engineering subagreement. The clause contained in appendix C...

40 CFR Appendix D to Subpart E of... - EPA Transition Policy-Existing Consulting Engineering Agreements

Code of Federal Regulations, 2010 CFR

2010-07-01

... Consulting Engineering Agreements D Appendix D to Subpart E of Part 35 Protection of Environment... Transition Policy—Existing Consulting Engineering Agreements a. access to records—audit 1. Access clause... access clause is included in the consulting engineering subagreement. The clause contained in appendix C...

40 CFR Appendix D to Subpart E of... - EPA Transition Policy-Existing Consulting Engineering Agreements

Code of Federal Regulations, 2011 CFR

2011-07-01

... Consulting Engineering Agreements D Appendix D to Subpart E of Part 35 Protection of Environment... Transition Policy—Existing Consulting Engineering Agreements a. access to records—audit 1. Access clause... access clause is included in the consulting engineering subagreement. The clause contained in appendix C...

Effects of FR235222, a novel HDAC inhibitor, in proliferation and apoptosis of human leukaemia cell lines: role of annexin A1.

PubMed

Petrella, Antonello; D'Acunto, Cosimo Walter; Rodriquez, Manuela; Festa, Michela; Tosco, Alessandra; Bruno, Ines; Terracciano, Stefania; Taddei, Maurizio; Paloma, Luigi Gomez; Parente, Luca

2008-03-01

FR235222, a novel histone deacetylase inhibitor (HDACi), at 50nM caused accumulation of acetylated histone H4, inhibition of cell proliferation and G1 cycle arrest accompanied by increase of p21 and down-regulation of cyclin E in human promyelocytic leukaemia U937 cells. The compound was also able to increase the protein and mRNA levels of annexin A1 (ANXA1) without effects on apoptosis. Similar effects were observed in human chronic myelogenous leukaemia K562 cells and human T cell leukaemia Jurkat cells. Cycle arrest and ANXA1 expression, without significant effects on apoptosis, were also induced by different HDACi like suberoylanilide hydroxamic acid (SAHA) and trichostatin-A (TSA). FR235222 at 0.5 microM stimulated apoptosis of all leukaemia cell lines associated to an increased expression of the full-length (37kDa) protein and the appearance of a 33kDa N-terminal cleavage product in both cytosol and membrane. These results suggest that ANXA1 expression may mediate cycle arrest induced by low doses FR235222, whereas apoptosis induced by high doses FR235222 is associated to ANXA1 processing.

Role of relativity in high-pressure phase transitions of thallium.

PubMed

Kotmool, Komsilp; Chakraborty, Sudip; Bovornratanaraks, Thiti; Ahuja, Rajeev

2017-02-20

We demonstrate the relativistic effects in high-pressure phase transitions of heavy element thallium. The known first phase transition from h.c.p. to f.c.c. is initially investigated by various relativistic levels and exchange-correlation functionals as implemented in FPLO method, as well as scalar relativistic scheme within PAW formalism. The electronic structure calculations are interpreted from the perspective of energetic stability and electronic density of states. The full relativistic scheme (FR) within L(S)DA performs to be the scheme that resembles mostly with experimental results with a transition pressure of 3 GPa. The s-p hybridization and the valence-core overlapping of 6s and 5d states are the primary reasons behind the f.c.c. phase occurrence. A recent proposed phase, i.e., a body-centered tetragonal (b.c.t.) phase, is confirmed with a small distortion from the f.c.c. phase. We have also predicted a reversible b.c.t. → f.c.c. phase transition at 800 GPa. This finding has been suggested that almost all the III-A elements (Ga, In and Tl) exhibit the b.c.t. → f.c.c. phase transition at extremely high pressure.

SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.

PubMed

Liu, Hong; Ma, Yan; He, Hong-Wei; Zhao, Wu-Li; Shao, Rong-Guang

2017-05-04

SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes invasion and metastasis in HCC remains to be clarified. Here, we reported that SPHK1 induced the epithelial-mesenchymal transition (EMT) by accelerating CDH1/E-cadherin lysosomal degradation and facilitating the invasion and metastasis of HepG2 cells. Initially, we found that SPHK1 promoted cell migration and invasion and induced the EMT process through decreasing the expression of CDH1, which is an epithelial marker. Furthermore, SPHK1 accelerated the lysosomal degradation of CDH1 to induce EMT, which depended on TRAF2 (TNF receptor associated factor 2)-mediated macroautophagy/autophagy activation. In addition, the inhibition of autophagy recovered CDH1 expression and reduced cell migration and invasion through delaying the degradation of CDH1 in SPHK1-overexpressing cells. Moreover, the overexpression of SPHK1 produced intracellular sphingosine-1-phosphate (S1P). In response to S1P stimulation, TRAF2 bound to BECN1/Beclin 1 and catalyzed the lysine 63-linked ubiquitination of BECN1 for triggering autophagy. The deletion of the RING domain of TRAF2 inhibited autophagy and the interaction of BECN1 and TRAF2. Our findings define a novel mechanism responsible for the regulation of the EMT via SPHK1-TRAF2-BECN1-CDH1 signal cascades in HCC cells. Our work indicates that the blockage of SPHK1 activity to attenuate autophagy may be a promising strategy for the prevention and treatment of HCC.

Search for weak M 1 transitions in 48Ca with inelastic proton scattering

NASA Astrophysics Data System (ADS)

Mathy, M.; Birkhan, J.; Matsubara, H.; von Neumann-Cosel, P.; Pietralla, N.; Ponomarev, V. Yu.; Richter, A.; Tamii, A.

2017-05-01

Background: The quenching of spin-isospin modes in nuclei is an important field of research in nuclear structure. It has an impact on astrophysical reaction rates and on fundamental processes like neutrinoless double-β decay. Gamow-Teller (GT) and spin-flip M 1 strengths are quenched. Concerning the latter, the Jπ=1+ resonance in the doubly magic nucleus 48Ca, dominated by a single transition, serves as a reference case. Purpose: The aim of the present work is to search for weak M 1 transitions in 48Ca with a high-resolution (p ,p') experiment at 295 MeV and forward angles including 0∘ and a comparison with results from a similar study using backward-angle electron scattering at low momentum transfers in order to estimate their contribution to the total B (M 1 ) strength in 48Ca. Methods: The spin-M 1 cross sections of individual peaks in the spectra are deduced with a multipole decomposition analysis (MDA) and converted to reduced spin-M 1 transition strengths by using the unit cross-section method. For a comparison with electron-scattering results, corresponding reduced B (M 1 ) transition strengths are extracted following the approach outlined in Birkhan et al. [Phys. Rev. C 93, 041302(R) (2016), 10.1103/PhysRevC.93.041302]. Results: In total, 30 peaks containing a M 1 contribution are found in the excitation energy region 7-13 MeV. The resulting B (M 1 ) strength distribution compares well to the electron-scattering results considering different factors limiting the sensitivity in both experiments and the enhanced importance of mechanisms breaking the proportionality of nuclear cross sections and electromagnetic matrix elements for weak transitions as studied here. The total strength of 1.14(7) μN2 deduced assuming a nonquenched isoscalar part of the (p ,p') cross sections agrees with the (e ,e') result of 1.21(13) μN2. A bin-wise analysis above 10 MeV provides an upper limit of 1.51(17) μN2. Conclusions: The present results confirm the previous electron

Transition Probabilities for Hydrogen-Like Atoms

NASA Astrophysics Data System (ADS)

Jitrik, Oliverio; Bunge, Carlos F.

2004-12-01

E1, M1, E2, M2, E3, and M3 transition probabilities for hydrogen-like atoms are calculated with point-nucleus Dirac eigenfunctions for Z=1-118 and up to large quantum numbers l=25 and n=26, increasing existing data more than a thousandfold. A critical evaluation of the accuracy shows a higher reliability with respect to previous works. Tables for hydrogen containing a subset of the results are given explicitly, listing the states involved in each transition, wavelength, term energies, statistical weights, transition probabilities, oscillator strengths, and line strengths. The complete results, including 1 863 574 distinct transition probabilities, lifetimes, and branching fractions are available at http://www.fisica.unam.mx/research/tables/spectra/1el

The GTC exoplanet transit spectroscopy survey. III. No asymmetries in the transit of CoRoT-29b

NASA Astrophysics Data System (ADS)

Pallé, E.; Chen, G.; Alonso, R.; Nowak, G.; Deeg, H.; Cabrera, J.; Murgas, F.; Parviainen, H.; Nortmann, L.; Hoyer, S.; Prieto-Arranz, J.; Nespral, D.; Cabrera Lavers, A.; Iro, N.

2016-05-01

Context. The launch of the exoplanet space missions obtaining exquisite photometry from space has resulted in the discovery of thousands of planetary systems with very different physical properties and architectures. Among them, the exoplanet CoRoT-29b was identified in the light curves the mission obtained in summer 2011, and presented an asymmetric transit light curve, which was tentatively explained via the effects of gravity darkening. Aims: Transits of CoRoT-29b are measured with precision photometry, to characterize the reported asymmetry in their transit shape. Methods: Using the OSIRIS spectrograph at the 10-m GTC telescope, we perform spectro-photometric differential observations, which allow us to both calculate a high-accuracy photometric light curve, and a study of the color-dependence of the transit. Results: After careful data analysis, we find that the previously reported asymmetry is not present in either of two transits, observed in July 2014 and July 2015 with high photometric precisions of 300 ppm over 5 min. Due to the relative faintness of the star, we do not reach the precision necessary to perform transmission spectroscopy of its atmosphere, but we see no signs of color-dependency of the transit depth or duration. Conclusions: We conclude that the previously reported asymmetry may have been a time-dependent phenomenon, which did not occur in more recent epochs. Alternatively, instrumental effects in the discovery data may need to be reconsidered. Light curves are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/589/A62

The transition mechanisms of the E to H mode and the H to E mode in an inductively coupled argon-mercury mixture discharge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Xiao; Yu, Peng-Cheng; Liu, Yu

2015-10-15

In our experiment, the transition points between the two operational modes of capacitive coupling (E mode) and inductive coupling (H mode) were investigated at a wide range of mercury vapor pressures in an inductively coupled plasma, varying with the input radio-frequency powers and the total filling pressures (10 Pa–30 Pa). The electron temperatures were calculated versus with the mercury vapor pressures for different values of the total filling pressures. The transition power points and electron density also were measured in this study. It is shown that the transition powers, whether the E to H mode transition or the H to E modemore » transition, are lower than that of the argon discharge, and these powers almost increase with the mercury vapor pressure rising. However, the transition electron density follows an inverse relationship with the mercury vapor pressures compared with the transition powers. In addition, at the lower pressures and higher mercury vapor pressures, an inverse hysteresis was observed clearly, which did not appear in the argon gas plasma. We suggest that all these results are attributed to the electron-neutral collision frequency changed with the additional mercury vapor pressures.« less

Electron-impact excitation of the 1{sup 1}{ital S}{r_arrow}3{sup 1}{ital P} and 1{sup 1}{ital S}{r_arrow}4{sup 1}{ital P} transitions in helium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khakoo, M.A.; Roundy, D.; Rugamas, F.

1996-11-01

The method of electron-photon coincidence is used to {open_quote}{open_quote}resolve{close_quote}{close_quote} the electron-impact excitation of the {ital n}{sup 1}{ital P} levels ({ital n}=3 and 4) from nearby levels. Experimentally determined ratios of the differential cross sections for the electron-impact excitation of 1{sup 1}{ital S}{r_arrow}2{sup 1}{ital P}, to 1{sup 1}{ital S}{r_arrow}3{sup 1}{ital P}, and 4{sup 1}{ital P} transitions are presented at 30-, 40-, and 80-eV incident electron energies. Differential cross sections for the 1{sup 1}{ital S}{r_arrow}3{sup 1}{ital P} and 1{sup 1}{ital S}{r_arrow}4{sup 1}{ital P} transitions are derived by normalizing these ratios to available experimental differential cross sections for the 1{sup 1}{ital S}{r_arrow}2{sup 1}{italmore » P} transition. The ratios and differential cross sections are compared to available theoretical and semiempirical data. {copyright} {ital 1996 The American Physical Society.}« less

Measurement of the methyl cyanide E/A ratio in TMC-1

NASA Technical Reports Server (NTRS)

Minh, Y. C.; Irvine, W. M.; Ohishi, M.; Ishikawa, S.; Saito, S.; Kaifu, N.

1993-01-01

We have observed the methyl cyanide (CH3CN) J = 2-1 K = 0 and 1 transitions toward the cyanopolyyne peak of TMC-1 and have derived an E/A (ortho/para)abundance ratio N(E)/N(A) = 0.75 +/- 0.10. The total methyl cyanide column density is N(total) = 5 x 10 exp 12/sq cm toward TMC-1, in agreement with earlier results from the J = 1-0 lines.

Numerical Study of the Transition Between Reentrant Jet and Twin Vortex Flow Regimes in Ventilated Cavitation

NASA Astrophysics Data System (ADS)

Adama Maiga, Mahamadou; Coutier-Delgosha, Olivier; Bois, Gérard

2018-06-01

Contrary to natural cavitation, ventilated cavitation is controllable and is not harmful. It is particularly used to reduce the drag of the hydraulic vehicles. The ventilated cavitation is characterized by various gas regimes. The mechanisms of ventilated cavitation are investigated in the present work with CFD based on a 2D solver. The attention is especially focused on the transition between the reentrant jet and twin vortex regimes. The results confirm that the product of ventilated cavitation number and Froude number is lower than 1 (σ c Fr < 1) in the twin vortex regime, while it is higher than 1 (σ c Fr > 1) in the reentrant jet regime, as reported in the literature. Further analysis shows that ventilated cavitation is significantly influenced by the natural cavitation number.

Health Care Transition in Patients With Type 1 Diabetes

PubMed Central

Garvey, Katharine C.; Wolpert, Howard A.; Rhodes, Erinn T.; Laffel, Lori M.; Kleinman, Ken; Beste, Margaret G.; Wolfsdorf, Joseph I.; Finkelstein, Jonathan A.

2012-01-01

OBJECTIVE To examine characteristics of the transition from pediatric to adult care in emerging adults with type 1 diabetes and evaluate associations between transition characteristics and glycemic control. RESEARCH DESIGN AND METHODS We developed and mailed a survey to evaluate the transition process in emerging adults with type 1 diabetes, aged 22 to 30 years, receiving adult diabetes care at a single center. Current A1C data were obtained from the medical record. RESULTS The response rate was 53% (258 of 484 eligible). The mean transition age was 19.5 ± 2.9 years, and 34% reported a gap >6 months in establishing adult care. Common reasons for transition included feeling too old (44%), pediatric provider suggestion (41%), and college (33%). Less than half received an adult provider recommendation and <15% reported having a transition preparation visit or receiving written transition materials. The most recent A1C was 8.1 ± 1.3%. Respondents who felt mostly/completely prepared for transition had lower likelihood of a gap >6 months between pediatric and adult care (adjusted odds ratio 0.47 [95% CI 0.25–0.88]). In multivariate analysis, pretransition A1C (β = 0.49, P < 0.0001), current age (β = −0.07, P = 0.03), and education (β = −0.55, P = 0.01) significantly influenced current posttransition A1C. There was no independent association of transition preparation with posttransition A1C (β = −0.17, P = 0.28). CONCLUSIONS Contemporary transition practices may help prevent gaps between pediatric and adult care but do not appear to promote improvements in A1C. More robust preparation strategies and handoffs between pediatric and adult care should be evaluated. PMID:22699289

E2/M1 mixing ratios in transitions from the gamma vibrational bands to the ground state rotational bands of 102, 104, 106, 108Mo, 108, 110, 112Ru, and 112, 114, 116Pd

NASA Astrophysics Data System (ADS)

Eldridge, J. M.; Fenker, B.; Hamilton, J. H.; Goodin, C.; Zachary, C. J.; Wang, E.; Ramayya, A. V.; Daniel, A. V.; Ter-Akopian, G. M.; Oganessian, Yu. Ts.; Luo, Y. X.; Rasmussen, J. O.; Zhu, S. J.

2018-02-01

E2/ M1 mixing ratios have been measured for transitions from states in the γ vibrational bands ( I+_{γ}) to states in the ground state bands (I+ or [I-1]+) of the neutron rich, even-even, deformed isotopes, 102, 104, 106, 108Mo, 108, 110, 112Ru, and 112, 114, 116Pd, including from states as high as 9+_{γ}. These measurements were done using the GAMMASPHERE detector array, which, at the time of the experiment, had 101 working HPGe detectors, arranged at 64 different angles. A 62 μCi source of 252Cf was placed inside GAMMASPHERE yielding 5.7× 10^{11} γ-γ-γ and higher coincidence events. The angular correlations between the transitions from the γ-bands to the ground bands, and the pure E2 transitions within the ground band were then measured. These angular correlations yielded the mixing ratios, demonstrating that these transitions are pure or nearly pure E2, in agreement with theory. In order to correct for possible attenuation due to the lifetime of the intermediate state in these correlations, the g-factors of the intermediate states needed to be known. Therefore, the g-factors of the 2+ states in the ground state band have been measured.

Pressure-induced phase transitions in the CdC r2S e4 spinel

NASA Astrophysics Data System (ADS)

Efthimiopoulos, I.; Liu, Z. T. Y.; Kucway, M.; Khare, S. V.; Sarin, P.; Tsurkan, V.; Loidl, A.; Wang, Y.

2016-11-01

We have conducted high-pressure x-ray diffraction and Raman spectroscopic studies on the CdC r2S e4 spinel at room temperature up to 42 GPa. We have resolved three structural transitions up to 42 GPa, i.e., the starting F d 3 ¯m phase transforms at ˜11 GPa into a tetragonal I 41/a m d structure, an orthorhombic distortion was observed at ˜15 GPa , whereas structural disorder initiates beyond 25 GPa. Our ab initio density functional theory studies successfully reproduced the observed crystalline-to-crystalline structural transitions. In addition, our calculations propose an antiferromagnetic ordering as a potential magnetic ground state for the high-pressure tetragonal and orthorhombic modifications, compared with the starting ferromagnetic phase. Furthermore, the computational results indicate that all phases remain insulating in their stability pressure range, with a direct-to-indirect band gap transition for the F d 3 ¯m phase taking place at 5 GPa. We attempted also to offer an explanation behind the peculiar first-order character of the F d 3 ¯m (cubic ) →I 41/a m d (tetragonal) transition observed for several relevant Cr spinels, i.e., the sizeable volume change at the transition point, which is not expected from space group symmetry considerations. We detected a clear correlation between the cubic-tetragonal transition pressures and the next-nearest-neighbor magnetic exchange interactions for the Cr-bearing sulfide and selenide members, a strong indication that the cubic-tetragonal transitions in these systems are principally governed by magnetic effects.

Optimization of Acidothermus Celluloyticus Endoglucanase (E1) Production in Transgenic Tobacco Plants by Transcriptional, Post-transcription and Post-Translational Modification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dai, Ziyu; Hooker, Brian S.; Quesenberry, Ryan D.

2005-10-01

Biochemical characteristics of Acidothermus cellulolyticus endoglucanase (E1) and its physiological effects in transgenic tobacco (Nicotiana tabacum) has been studied previously. In an attempt to obtain a high level of production of intact E1 in transgenic plants, the E1 gene was expressed under the control of strong Mac promoter (a hybrid promoter of manopine synthase promoter and cauliflower mosaic virus 35S promoter enhancer region) or tomato Rubisco small subunit (RbcS-3C) promoter with different 5’ untranslated leader (UTL) sequence and targeted to different subcellular comartmentations with various transit peptides. The expression of E1 protein in transgenic tobacco plants was determined via E1more » activity, protein immunobloting, and RNA gel-blotting analyses. Effects of different transit peptides on E1 protein production and its stability were examined in transgenic tobacco plants carrying one of six transgene expression vectors with the same (Mac) promoter and transcription terminator (Tmas). Transgenic tobacco plants with apoplast transit peptide (Mm-apo) had the highest average E1 activity and protein accumulation , while E1 protein was more stable in transgenic plants with no transit peptide (Mm) than others. The E1 expression under tomato RbcS-3C promoter was higher than that under Mac promoter based on the average E1 activity, E1 protein accumulation, and RNA gel-blotting. The E1 expression was increased more than two fold when the 5’-UTL of alfalfa mosaic virus RNA4 gene replaced the UTL of RbcS-3C promoter, while the UTL of alfalfa mosaic virus RNA4 gene was less effective than the UTL of Mac promoter. The optimal combination of promoter, 5’-UTL, and subcellular compartmentation (transit peptide) for E1 protein production in transgenic tobacco plants are discussed.« less

Flight and wind-tunnel correlation of boundary-layer transition on the AEDC transition cone

NASA Technical Reports Server (NTRS)

Fisher, D. L.; Dougherty, N. S., Jr.

1982-01-01

Transition and fluctuating surface pressure data were acquired on a 10 deg included angle cone, using the same instrumentation and technique over a wide range of Mach and Reynolds numbers in 23 wind tunnels and in flight. Transition was detected with a traversing pitot-pressure probe in contact with the surface. The surface pressure fluctuations were measured with microphones set flush in the cone surface. Good correlation of end of transition Reynolds number RE(T) was obtained between data from the lower disturbance wind tunnels and flight up to a boundary layer edge Mach number, M(e) = 1.2. Above M(e) = 1.2, however, this correlation deteriorates, with the flight Re(T) being 25 to 30% higher than the wind tunnel Re(T) at M(e) = 1.6. The end of transition Reynolds number correlated within + or - 20% with the surface pressure fluctuations, according to the equation used. Broad peaks in the power spectral density distributions indicated that Tollmien-Schlichting waves were the probable cause of transition in flight and in some of the wind tunnels.

Transition metal ion capture using functional mesoporous carbon made with 1,10-phenanthroline

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chouyyok, Wilaiwan; Yantasee, Wassana; Shin, Yongsoon

2009-11-01

Functional mesoporous carbon has been built using 1,10-phenanthroline as the fundamental building block, resulting in a nanoporous, high surface area sorbent capable of selectively binding transition metal ions. This material had a specific surface area of 870 m2/g, an average pore size of about 30Å, and contained as much as 8.2 weight percent N. Under acidic conditions, where the 1,10-phenanthroline ligand is protonated, this material was found to be an effective anion exchange material for transition metal anions like PdCl4-2 and H2VO4-1. 1,10-phenanthroline functionalized mesoporous carbon (“Phen-FMC”) was found to have a high affinity for Cu(II), even down to amore » pH of 1. At pHs above 5, Phen-FMC was found to bind a variety of transition metal cations (e.g. Co(II), Ni(II), Zn(II), etc.) from filtered ground water, river water and seawater. Phen-FMC displayed rapid sorption kinetics with Co(II) in filtered river water, reaching equilibrium in less than an hour, and easily lowering the [Co(II)] to sub-ppb levels. Phen-FMC was found to be more effective for transition metal ion capture than ion exchange resin or activated carbon.« less

GROUND-BASED TRANSIT OBSERVATIONS OF THE SUPER-EARTH 55 Cnc e

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Mooij, E. J. W.; López-Morales, M.; Karjalainen, R.

2014-12-20

We report the first ground-based detections of the shallow transit of the super-Earth exoplanet 55 Cnc e using a 2 m class telescope. Using differential spectrophotometry, we observed one transit in 2013 and another in 2014, with average spectral resolutions of ∼700 and ∼250, spanning the Johnson BVR photometric bands. We find a white light planet-to-star radius ratio of 0.0190{sub −0.0027}{sup +0.0023} from the 2013 observations and 0.0200{sub −0.0018}{sup +0.0017} from the 2014 observations. The two data sets combined result in a radius ratio of 0.0198{sub −0.0014}{sup +0.0013}. These values are all in agreement with previous space-based results. Scintillation noise in themore » data prevents us from placing strong constraints on the presence of an extended hydrogen-rich atmosphere. Nevertheless, our detections of 55 Cnc e in transit demonstrate that moderate-sized telescopes on the ground will be capable of routine follow-up observations of super-Earth candidates discovered by the Transiting Exoplanet Survey Satellite around bright stars. We expect it also will be possible to place constraints on the atmospheric characteristics of those planets by devising observational strategies to minimize scintillation noise.« less

Study of dipion transitions among Υ(3S), Υ(2S), and Υ(1S) states

NASA Astrophysics Data System (ADS)

Cronin-Hennessy, D.; Gao, K. Y.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.; Poling, R.; Scott, A. W.; Smith, A.; Zweber, P.; Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tomaradze, A.; Ernst, J.; Ecklund, K. M.; Severini, H.; Love, W.; Savinov, V.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J.; Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Hu, D.; Moziak, B.; Napolitano, J.; He, Q.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.; Artuso, M.; Blusk, S.; Khalil, S.; Li, J.; Menaa, N.; Mountain, R.; Nisar, S.; Randrianarivony, K.; Sia, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Bonvicini, G.; Cinabro, D.; Dubrovin, M.; Lincoln, A.; Pappas, S. P.; Weinstein, A. J.; Asner, D. M.; Edwards, K. W.; Naik, P.; Briere, R. A.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Adam, N. E.; Alexander, J. P.; Cassel, D. G.; Duboscq, J. E.; Ehrlich, R.; Fields, L.; Galik, R. S.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.; Jones, C. D.; Kandaswamy, J.; Kreinick, D. L.; Kuznetsov, V. E.; Mahlke-Krüger, H.; Mohapatra, D.; Onyisi, P. U. E.; Patterson, J. R.; Peterson, D.; Pivarski, J.; Riley, D.; Ryd, A.; Sadoff, A. J.; Schwarthoff, H.; Shi, X.; Stroiney, S.; Sun, W. M.; Wilksen, T.; Athar, S. B.; Patel, R.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Selen, M.; White, E. J.; Wiss, J.; Mitchell, R. E.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.

2007-10-01

We present measurements of decay matrix elements for hadronic transitions of the form Υ(nS)→Υ(mS)ππ, where (n,m)=(3,1),(2,1),(3,2). We reconstruct charged and neutral pion modes with the final state Upsilon decaying to either μ+μ- or e+e-. Dalitz plot distributions for the 12 decay modes are fit individually as well as jointly assuming isospin symmetry, thereby measuring the matrix elements of the decay amplitude. We observe and account for the anomaly previously noted in the dipion invariant mass distribution for the Υ(3S)→Υ(1S)ππ transition and obtain good descriptions of the dynamics of the decay using the most general decay amplitude allowed by partial conservation of the axial-vector current considerations. The fits further indicate that the Υ(2S)→Υ(1S)ππ and Υ(3S)→Υ(2S)ππ transitions also show the presence of terms in the decay amplitude that were previously ignored, although at a relatively suppressed level.

WASP-80b: a gas giant transiting a cool dwarf

NASA Astrophysics Data System (ADS)

Triaud, A. H. M. J.; Anderson, D. R.; Collier Cameron, A.; Doyle, A. P.; Fumel, A.; Gillon, M.; Hellier, C.; Jehin, E.; Lendl, M.; Lovis, C.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smalley, B.; Smith, A. M. S.; Udry, S.; West, R. G.; Wheatley, P. J.

2013-03-01

We report the discovery of a planet transiting the star WASP-80 (1SWASP J201240.26-020838.2; 2MASS J20124017-0208391; TYC 5165-481-1; BPM 80815; V = 11.9, K = 8.4). Our analysis shows this is a 0.55 ± 0.04 Mjup, 0.95 ± 0.03 Rjup gas giant on a circular 3.07 day orbit around a star with a spectral type between K7V and M0V. This system produces one of the largest transit depths so far reported, making it a worthwhile target for transmission spectroscopy. We find a large discrepancy between the vsini⋆ inferred from stellar line broadening and the observed amplitude of the Rossiter-McLaughlin effect. This can be understood either by an orbital plane nearly perpendicular to the stellar spin or by an additional, unaccounted for source of broadening. Using WASP-South photometric observations, from Sutherland (South Africa), confirmed with the 60 cm TRAPPIST robotic telescope, EulerCam, and the CORALIE spectrograph on the Swiss 1.2 m Euler Telescope, and HARPS on the ESO 3.6 m (Prog ID 089.C-0151), all three located at La Silla Observatory, Chile.Radial velocity and photometric data are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr(130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/551/A80

YB-1 overexpression promotes a TGF-β1-induced epithelial–mesenchymal transition via Akt activation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ha, Bin; Lee, Eun Byul; Cui, Jun

2015-03-06

The Y-box binding protein-1 (YB-1) is a transcription/translation regulatory protein, and the expression thereof is associated with cancer aggressiveness. In the present study, we explored the regulatory effects of YB-1 during the transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma cells. Downregulation of YB-1 increased E-cadherin promoter activity, and upregulation of YB-1 decreased promoter activity, suggesting that the YB-1 level may be correlated with the EMT. TGF-β1 induced YB-1 expression, and TGF-β1 translocated cytosolic YB-1 into the nucleus. YB-1 overexpression promoted TGF-β1-induced downregulation of epithelial markers, upregulation of mesenchymal markers, and cell migration. Moreover, YB-1 overexpression enhanced themore » expression of E-cadherin transcriptional repressors via TGF-β1-induced Akt activation. Our findings afford new insights into the role played by YB-1 in the TGF-β1 signaling pathway. - Highlights: • YB-1 regulates E-cadherin expression in A549 cells. • TGF-β1 induces upregulating and nuclear localization of YB-1. • YB-1 overexpression accelerates TGF-β1-induced EMT and cell migration. • YB-1 regulates Snail and Slug expression via Akt activation.« less

Warrior Transition Leader: Medical Rehabilitation Handbook

DTIC Science & Technology

2011-01-01

serve. rE f E r E n c E S 1. http://www.army.mil/warriorcarenews/. Accessed January 24, 2011. 2. Warrior Transition Command Web site. http...www.wtc.army.mil/about_us/ ctp.html. Accessed January 24, 2011. 3. Leipold JD. Warrior Transition Command stands up at Pentagon. US Army Web site. Army...January 24, 2011. 4. Warrior Transition Command Web site. http://wtc.armylive.dodlive.mil/ about-wtu/. Accessed January 24, 2011. 5. Leipold JD

78 FR 66251 - Electronic Fund Transfers(Regulation E)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-05

... BUREAU OF CONSUMER FINANCIAL PROTECTION 12 CFR Part 1005 [Docket No. CFPB-2013-0032] RIN 3170-AA33... list periodically. DATES: This list is effective on October 28, 2013. The Bureau will next consider..., 2013 (78 FR 30662), and August 14, 2013 (78 FR 49365) (collectively the Final Rule), takes effect on...

Science with the space-based interferometer eLISA. II: gravitational waves from cosmological phase transitions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caprini, Chiara, E-mail: chiara.caprini@cea.fr; Hindmarsh, Mark; Huber, Stephan

We investigate the potential for the eLISA space-based interferometer to detect the stochastic gravitational wave background produced by strong first-order cosmological phase transitions. We discuss the resulting contributions from bubble collisions, magnetohydrodynamic turbulence, and sound waves to the stochastic background, and estimate the total corresponding signal predicted in gravitational waves. The projected sensitivity of eLISA to cosmological phase transitions is computed in a model-independent way for various detector designs and configurations. By applying these results to several specific models, we demonstrate that eLISA is able to probe many well-motivated scenarios beyond the Standard Model of particle physics predicting strong first-ordermore » cosmological phase transitions in the early Universe.« less

E 2 / M 1 Mixing Ratios in Transitions From the Gamma-Vibrational-Bands to the Ground-State-Rotational-Bands of 102 , 104 , 106 , 108Mo, 108 , 110 , 112Ru, and 112 , 114 , 116Pd

NASA Astrophysics Data System (ADS)

Eldridge, Jonathan M.; Fenker, B.; Goodin, C.; Hamilton, J. H.; Wang, E. H.; Ramayya, A. V.; Daniel, A. V.; Ter-Akopian, G. M.; Luo, Y. X.; Rasmussen, J. O.; Oganesson, Yu. Ts.; Zhu, S. J.

2017-09-01

E 2 / M 1 mixing ratios have been measured for transitions from states in the γ-vibrational-bands (Iγ+) to states in the ground-state-bands (Ig+ or [I- 1 ] g +) of the neutron rich, deformed isotopes, 102 , 104 , 106 , 108Mo, 108 , 110 , 112Ru, and 112 , 114 , 116Pd, including from states as high as 9γ+. These measurements were done using the GAMMASPHERE detector array, which, at the time of the experiment, had 101 working HPGe detectors, arranged at 64 different angles. A 62 μCi source of 252Cf was placed inside GAMMASPHERE yielding 5.7 ×1011 γ - γ - γ and higher coincidence events. The angular correlation between the transitions from the γ-band to the ground band, and the pure E2 transitions within the ground band were then measured. These angular correlations yielded the mixing ratios, demonstrating that these transitions are all pure or nearly pure E2, in agreement with theory. In order to correct for possible attenuation due to the lifetime of the intermediate state in these correlations, the g-factors of the intermediate states needed to be known. Therefore, the g-factors of the 2g+ states in the ground state band have been measured. Supported by the US Department of Energy; Grant No. DE-FG0588ER40407, Contract No. DE-AC03-76SF00098.

Acoustic waves and the detectability of first-order phase transitions by eLISA

NASA Astrophysics Data System (ADS)

Weir, David J.

2017-05-01

In various extensions of the Standard Model it is possible that the electroweak phase transition was first order. This would have been a violent process, involving the formation of bubbles and associated shock waves. Not only would the collision of these bubbles and shock waves be a detectable source of gravitational waves, but persistent acoustic waves could enhance the signal and improve prospects of detection by eLISA. I summarise the results of a recent campaign to model such a phase transition based on large-scale hydrodynamical simulations, and its implications for the eLISA mission.

Magnetic Field Driven Change of the Density of States of Amorphous Gd_xSi_1-x at the Metal Insulator Transition

NASA Astrophysics Data System (ADS)

Teizer, W.; Hellman, F.; Dynes, R. C.; Ucsd Physics Department Collaboration

2000-03-01

We have determined the density of states of amorphous Gd_xSi_1-x, N(E), through the Metal-Insulator transition by tunneling measurements. Gd_xSi_1-x shows a strong negative magnetoresistance at low temperature [1] and can be driven through the Metal-Insulator transition by applying a magnetic field [2]. In H=0, the conductance dI/dV across a Gd_xSi_1-x/oxide/Pb tunnel junction is dominated by a sharp superconducting Pb gap edge and Pb phonons indicating the presence of single step quantum tunneling. As a small magnetic field (H=1kOe) is applied, effects of the superconductivity of Pb disappear and at low voltages it is reasonable to approximate dI/dV N(E). We find that N(E) increases with magnetic field. On the metallic side of the Metal-Insulator transition, the density of states at zero bias, N(0), approximately scales with the extrapolated T=0 transport conductivity σ_0. A change of N(0) thus causes a change in σ_0. The Metal-Insulator transition occurs when N(0) goes to 0. [1] F. Hellman, M. Q. Tran, A. E. Gebala, E. M. Wilcox and R. C. Dynes. Phys. Rev. Lett. bf77, 4652 (1996). P. Xiong, B. I. Zink, S. I. Applebaum, F. Hellman and R. C. Dynes. Phys. Rev. B bf59, 3929 (1999). [2] W. Teizer, F. Hellman and R. C. Dynes. To be published.

75 FR 63709 - Revocation of Class C Airspace, Establishment of Class D Airspace, and Modification of Class E...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... foot Class E airspace at Columbus, GA. The FAA is taking this action because Columbus Metropolitan... area and the 700 foot Class E airspace area at Columbus, GA (75 FR 27670). Interested parties were... from 700 feet above the surface at Columbus, Ga. The radius of the Class E surface area at the airport...

Precision Measurements of the B(E1) Strengths in 11Be

NASA Astrophysics Data System (ADS)

Kwan, E.; Wu, C. Y.; Summers, N. C.; Hackman, G.; Drake, T. E.; Andreoiu, C.; Ashley, R.; Ball, G. C.; Bender, P. C.; Boston, A. J.; Boston, H. C.; Chester, A.; Close, A.; Cline, D.; Cross, D. S.; Dunlop, R.; Finley, A.; Garnsworthy, A.; Hayes, A. B.; Laffoley, A. T.; Nano, T.; Navrátil, P.; Pearson, C. J.; Pore, J.; Starosta, K.; Thompson, I. J.; Voss, P.; Williams, S. J.; Wang, Z. M.

2014-09-01

The electromagnetic transition strength between the two bound states were measured in the one-neutron halo nucleus 11Be from Coulomb excitation on 196Pt at projectile energies of 1.727 and 2.086 MeV/nucleon at TRIUMF. A B(E1) strength of 0.102(2) e2fm2, deduced from the forward-scattering data, is consistent with previous Coulomb excitation measurements at intermediate projectile energies with a model-dependent analysis.

Isotopologue-selective excitation studied via optical-optical double resonance using the E3 Σ1+(63S1) ←A3Π0+(53P1) ←X1Σ0+(51S0) transitions in CdAr and CdKr van der Waals complexes

NASA Astrophysics Data System (ADS)

Urbańczyk, T.; Dudek, J.; Koperski, J.

2018-06-01

A method of experimental selection of molecular isotopologues using optical-optical double resonance (OODR) scheme and supersonic beam source of van der Waals (vdW) complexes is presented. Due to an appropriately large isotopic shift, the proper choice of a wavenumber of a sufficiently narrowband laser in the first transition of OODR scheme can lead to a selective isotopologue excitation to the intermediate state. Thanks to this approach, it is possible to select some of the isotopologues which subsequently give a contribution to laser induced fluorescence (LIF) signal originated from the final state of OODR. In this article, results of tests of the proposed method that employs the E3 Σ1+ ←A3Π0+ ←X1Σ0+ transitions in two vdW complexes, CdKr and CdAr, are presented and analysed.

77 FR 15357 - 1-Hydroxyethylidene-1, 1-Diphosphonic Acid From India: Final Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-15

...-Diphosphonic Acid From India: Final Results of Antidumping Duty Administrative Review AGENCY: Import... the antidumping duty order on 1-Hydroxyethylidene-1, 1-Diphosphonic Acid from India. The review covers...-Diphosphonic Acid from India (76 FR 78237). We invited parties to comment on the preliminary results of the...

Transit Illustration of TRAPPIST-1

NASA Image and Video Library

2017-02-22

This illustration shows the seven TRAPPIST-1 planets as they might look as viewed from Earth using a fictional, incredibly powerful telescope. The sizes and relative positions are correctly to scale: This is such a tiny planetary system that its sun, TRAPPIST-1, is not much bigger than our planet Jupiter, and all the planets are very close to the size of Earth. Their orbits all fall well within what, in our solar system, would be the orbital distance of our innermost planet, Mercury. With such small orbits, the TRAPPIST-1 planets complete a "year" in a matter of a few Earth days: 1.5 for the innermost planet, TRAPPIST-1b, and 20 for the outermost, TRAPPIST-1h. This particular arrangement of planets with a double-transit reflect an actual configuration of the system during the 21 days of observations made by NASA's Spitzer Space Telescope in late 2016. The system has been revealed through observations from NASA's Spitzer Space Telescope and the ground-based TRAPPIST (TRAnsiting Planets and PlanetesImals Small Telescope) telescope, as well as other ground-based observatories. The system was named for the TRAPPIST telescope. http://photojournal.jpl.nasa.gov/catalog/PIA21429

Vibrational spectroscopic study on polymorphism of erucic acid and palmitoleic acid: γ1→α1 and γ→α reversible solid state phase transitions

NASA Astrophysics Data System (ADS)

Kaneko, Fumitoshi; Yamazaki, Kazuhiro; Kobayashi, Masamichi; Sato, Kiyotaka; Suzuki, Masao

1994-08-01

The infrared and Raman spectra of four polymorphic phases (α, α1, γ and γ1) of erucic acid ( cis-13-docosenoic acid) and those of two polymorphic phases (α and γ) of palmitoleic acid ( cis-9-hexadecenoic acid) were investigated. The γ and γ1 phases of erucic acid were analyzed on the basis of crystal structures determined by us. There were large spectral differences between γ and γ1 phases, which could be ascribed to the differences in the conformation of cis-olefin groups and the subcell structure. Two types of reversible solid state phase transitions (γ→α and γ1→α1 transitions) were followed by the infrared and Raman spectra. It was concluded that the mechanism of the γ→α phase transition of erucic and palmitoleic acids is essentially the same as that of oleic acid previously reported by us [ J. Phys. Chem.90, 6371 (1986)], i.e. this phase transition is of order-disorder type accompanied by a conformational disordering at the methyl-terminal chain. Spectral changes on the γ1→α1 transition suggested that a similar structural change took place during this transition but there were large structural differences between α and α1.

Characterizing Giant Exoplanets through Multiwavelength Transit Observations: XO-1 b

NASA Astrophysics Data System (ADS)

Cole, Jackson Lane; Gardner, Cristilyn N.; Garver, Bethany R.; Jarka, Kyla L.; Kar, Aman; McGough, Aylin M.; PeQueen, David J.; Rivera, Daniel Ivan; Kasper, David; Jang-Condell, Hannah; Kobulnicky, Henry; Dale, Daniel

2018-01-01

Multiwavelength observations of transiting exoplanets can reveal wavelength dependence of the observed transit depth (or a lack thereof), thereby allowing for thorough characterization of their atmospheres. In support of a larger project performing these characterizations of 12 transiting giant exoplanets through 66 nights of continuous observation at the 2.3 m Wyoming Infrared Observatory (WIRO), we report an updated ephemeris for transiting exoplanet XO- 1 b. We carried out an MCMC analysis on photometric data obtained using the standard broad bandpass Sloan filter system. Our data set for XO-1 b is the most limited of those contributing to the larger project, the target having only been successfully observed from the transit midpoint to the egress on one night with limited out-of-transit data available. Exoplanet XO-1 b is a planet transiting star XO-1 (GSC 02041-01657) of type G1 V with V = 11.19 McCullough et al. (2006). This work is supported by the National Science Foundation under REU grant AST 1560461.

Evolution of E × B shear and coherent fluctuations prior to H-L transitions in DIII-D and control strategies for H-L transitions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eldon, David; Boivin, Rejean L.; Chrystal, Colin

While operating a magnetic fusion device in H-mode has many advantages, care must be taken to understand and control the release of energy during the H-L back transition, as the extra energy stored within the H-mode transport barrier will have the potential to cause damage to material components of a large future tokamak such as ITER. Examining a scenario where the H-L back transition sequence begins before the E × B shearing layer decays on its own, we identify a long-lived precursor mode that is tied to the events of the H-L sequence and we develop a robust control strategymore » for ensuring gradual release of energy during the transition sequence. Back transitions in this scenario commonly begin with a rapid relaxation of the pedestal, which was previously shown to be inconsistent with ideal peeling-ballooning instability as the trigger, despite being otherwise similar to a large type-I Edge Localized Mode (ELM). Here, this so-called transient occurs when the E × B shearing rate ω E×B is significantly larger than the turbulence decorrelation rate ωT, indicating that this is not the result of runaway turbulence recovery. The transient is always synchronous with amplitude and propagation velocity modulations of the precursor mode, which has been dubbed the Modulating Pedestal Mode (MPM).The MPM is a coherent density fluctuation, which, in our scenario at least, reliably appears in the steep gradient region with f ≈ 70 kHz, k θ ≈ 0.3 cm –1, and it exists for ≳100 ms before the onset of back transitions. The transient may be reliably eliminated by reducing toroidal rotation in the co-current direction by the application of torque from counter-injecting neutral beams. The transient in these “soft” H-L transitions is then replaced by a small type-III ELM, which is also always synchronous with the MPM, and MPM shows the same behavior in both hard and soft cases.« less

Evolution of E × B shear and coherent fluctuations prior to H-L transitions in DIII-D and control strategies for H-L transitions

DOE PAGES

Eldon, David; Boivin, Rejean L.; Chrystal, Colin; ...

2015-11-19

While operating a magnetic fusion device in H-mode has many advantages, care must be taken to understand and control the release of energy during the H-L back transition, as the extra energy stored within the H-mode transport barrier will have the potential to cause damage to material components of a large future tokamak such as ITER. Examining a scenario where the H-L back transition sequence begins before the E × B shearing layer decays on its own, we identify a long-lived precursor mode that is tied to the events of the H-L sequence and we develop a robust control strategymore » for ensuring gradual release of energy during the transition sequence. Back transitions in this scenario commonly begin with a rapid relaxation of the pedestal, which was previously shown to be inconsistent with ideal peeling-ballooning instability as the trigger, despite being otherwise similar to a large type-I Edge Localized Mode (ELM). Here, this so-called transient occurs when the E × B shearing rate ω E×B is significantly larger than the turbulence decorrelation rate ωT, indicating that this is not the result of runaway turbulence recovery. The transient is always synchronous with amplitude and propagation velocity modulations of the precursor mode, which has been dubbed the Modulating Pedestal Mode (MPM).The MPM is a coherent density fluctuation, which, in our scenario at least, reliably appears in the steep gradient region with f ≈ 70 kHz, k θ ≈ 0.3 cm –1, and it exists for ≳100 ms before the onset of back transitions. The transient may be reliably eliminated by reducing toroidal rotation in the co-current direction by the application of torque from counter-injecting neutral beams. The transient in these “soft” H-L transitions is then replaced by a small type-III ELM, which is also always synchronous with the MPM, and MPM shows the same behavior in both hard and soft cases.« less

SOPHIE velocimetry of Kepler transit candidates. XII. KOI-1257 b: a highly eccentric three-month period transiting exoplanet

NASA Astrophysics Data System (ADS)

Santerne, A.; Hébrard, G.; Deleuil, M.; Havel, M.; Correia, A. C. M.; Almenara, J.-M.; Alonso, R.; Arnold, L.; Barros, S. C. C.; Behrend, R.; Bernasconi, L.; Boisse, I.; Bonomo, A. S.; Bouchy, F.; Bruno, G.; Damiani, C.; Díaz, R. F.; Gravallon, D.; Guillot, T.; Labrevoir, O.; Montagnier, G.; Moutou, C.; Rinner, C.; Santos, N. C.; Abe, L.; Audejean, M.; Bendjoya, P.; Gillier, C.; Gregorio, J.; Martinez, P.; Michelet, J.; Montaigut, R.; Poncy, R.; Rivet, J.-P.; Rousseau, G.; Roy, R.; Suarez, O.; Vanhuysse, M.; Verilhac, D.

2014-11-01

In this paper we report a new transiting warm giant planet: KOI-1257 b. It was first detected in photometry as a planet-candidate by the Kepler space telescope and then validated thanks to a radial velocity follow-up with the SOPHIE spectrograph. It orbits its host star with a period of 86.647661 d ± 3 s and a high eccentricity of 0.772 ± 0.045. The planet transits the main star of a metal-rich, relatively old binary system with stars of mass of 0.99 ± 0.05 M⊙ and 0.70 ± 0.07 M⊙ for the primary and secondary, respectively. This binary system is constrained thanks to a self-consistent modelling of the Kepler transit light curve, the SOPHIE radial velocities, line bisector and full-width half maximum (FWHM) variations, and the spectral energy distribution. However, future observations are needed to confirm it. The PASTIS fully-Bayesian software was used to validate the nature of the planet and to determine which star of the binary system is the transit host. By accounting for the dilution from the binary both in photometry and in radial velocity, we find that the planet has a mass of 1.45 ± 0.35 M⊙ , and a radius of 0.94 ± 0.12 R⊙ , and thus a bulk density of 2.1 ± 1.2 g cm-3. The planet has an equilibrium temperature of 511 ± 50 K, making it one of the few known members of the warm-Jupiter population. The HARPS-N spectrograph was also used to observe a transit of KOI-1257 b, simultaneously with a joint amateur and professional photometric follow-up, with the aim of constraining the orbital obliquity of the planet. However, the Rossiter-McLaughlin effect was not clearly detected, resulting in poor constraints on the orbital obliquity of the planet. Based on observations made with SOPHIE on the 1.93 m telescope at Observatoire de Haute-Provence (CNRS), France, and with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish

A 1,574-Day Periodicity of Transits Orbiting KIC 8462852

NASA Astrophysics Data System (ADS)

Sacco, G.; Ngo, L. D.; Modolo, J.

2018-06-01

Observations of the main sequence F3V star KIC 8462852 (also known as Boyajianís star) revealed extreme aperiodic dips in flux up to 20% during the four years of the Kepler mission. Smaller dips (< 3%) were also observed with ground-based telescopes between May 2017 and May 2018. We investigated possible correlation between recent dips and the major dips in the last 100 days of the Kepler mission. We compared Kepler light curve data, 2017 data from two observatories (TFN, OGG) which are part of the Las Cumbres Observatory (LCO) network, as well as archival data from the Harvard College Observatory (HCO), Sonneberg Observatory, and Sternberg Observatory, and determined that observations appear consistent with a 1,574-day (4.31-year) periodicity of a transit (or group of transits) orbiting Boyajianís star within the habitable zone. Comparison with future observations is required to validate this hypothesis. Furthermore, it is unknown if transits that have produced other major dips as observed during the Kepler mission (e.g. D792) share the same orbital period. Nevertheless, the proposed periodicity is a step forward in guiding future observation efforts.

Reduced probabilities for E2 transitions between excited collective states of triaxial even–even nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nadyrbekov, M. S., E-mail: nodirbekov@inp.uz; Bozarov, O. A.

Reduced probabilities for intra- and interband E2 transitions in excited collective states of even–even lanthanide and actinide nuclei are analyzed on the basis of a model that admits an arbitrary triaxiality. They are studied in detail in the energy spectra of {sup 154}Sm, {sup 156}Gd, {sup 158}Dy, {sup 162,164}Er, {sup 230,232}Th, and {sup 232,234,236,238}U even–even nuclei. Theoretical and experimental values of the reduced probabilities for the respective E2 transitions are compared. This comparison shows good agreement for all states, including high-spin ones. The ratios of the reduced probabilities for the E2 transitions in question are compared with results following frommore » the Alaga rules. These comparisons make it possible to assess the sensitivity of the probabilities being considered to the presence of quadrupole deformations.« less

Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells.

PubMed

Howley, B V; Hussey, G S; Link, L A; Howe, P H

2016-03-31

The epithelial-to-mesenchymal transition (EMT) is a cellular process that functions during embryonic development and tissue regeneration, thought to be aberrantly activated in epithelial-derived cancer and has an important role in the process of metastasis. The transforming growth factor (TGF)-β signaling pathway is a key inducer of EMT and we have elucidated a posttranscriptional mechanism by which TGFβ modulates expression of select transcripts via the RNA-binding protein hnRNP E1 during EMT. One such transcript inhibin βA is a member of the TGFβ superfamily. Here, we show by polysome profiling that inhibin βA is translationally regulated by TGFβ via hnRNP E1. TGFβ treatment or knockdown of hnRNP E1 relieves silencing of the inhibin βA transcript, resulting in increased protein expression and secreted levels of the inhibin βA homodimer, activin A. Our data indicate that the translational upregulation of inhibin βA enhances the migration and invasion of cells that have undergone an EMT and promotes cancer progression in vivo.

77 FR 12826 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...Energy submits FE-AMP Meter Installation & Maintenance Service Agreement No. 3199 to be effective 1/26..., 2012. Nathaniel J. Davis, Sr., Deputy Secretary. [FR Doc. 2012-5065 Filed 3-1-12; 8:45 am] BILLING CODE...

Precise Determination of the Lyman-1 Transition Energy in Hydrogen-like Gold Ions with Microcalorimeters

NASA Astrophysics Data System (ADS)

Kraft-Bermuth, S.; Andrianov, V.; Bleile, A.; Echler, A.; Egelhof, P.; Grabitz, P.; Kilbourne, C.; Kiselev, O.; McCammon, D.; Scholz, P.

2014-09-01

The precise determination of the transition energy of the Lyman-1 line in hydrogen-like heavy ions provides a sensitive test of quantum electrodynamics in very strong Coulomb fields. We report the determination of the Lyman-1 transition energy of gold ions (Au) with microcalorimeters at the experimental storage ring at GSI. X-rays produced by the interaction of 125 MeV/u Au ions with an internal argon gas-jet target were detected. The detector array consisted of 14 pixels with silicon thermistors and Sn absorbers, for which an energy resolution of 50 eV for an X-ray energy of 59.5 keV was obtained in the laboratory. The Lyman-1 transition energy was determined for each pixel in the laboratory frame, then transformed into the emitter frame and averaged. A Dy-159 source was used for energy calibration. The absolute positions of the detector pixels, which are needed for an accurate correction of the Doppler shift, were determined by topographic measurements and by scanning a collimated Am-241 source across the cryostat window. The energy of the Lyman-1 line in the emitter frame is eV, in good agreement with theoretical predictions. The systematic error is dominated by the uncertainty in the position of the cryostat relative to the interaction region of beam and target.

Evidence for two spin-glass transitions with magnetoelastic and magnetoelectric couplings in the multiferroic (B i1 -xB ax) (F e1 -xT ix ) O3 system

NASA Astrophysics Data System (ADS)

Kumar, Arun; Kaushik, S. D.; Siruguri, V.; Pandey, Dhananjai

2018-03-01

For disordered Heisenberg systems with small single ion anisotropy (D ), two spin-glass (SG) transitions below the long-range ordered (LRO) phase transition temperature (Tc) have been predicted theoretically for compositions close to the percolation threshold. Experimental verification of these predictions is still controversial for conventional spin glasses. We show that multiferroic spin-glass systems can provide a unique platform for verifying these theoretical predictions via a study of change in magnetoelastic and magnetoelectric couplings, obtained from an analysis of diffraction data, at the spin-glass transition temperatures (TSG). Results of macroscopic (dc M (H , T ), M(t ), ac susceptibility [χ (ω, T )], and specific heat (Cp)) and microscopic (x-ray and neutron scattering) measurements are presented on disordered BiFe O3 , a canonical Heisenberg system with small single ion anisotropy, which reveal appearance of two spin-glass phases, SG1 and SG2, in coexistence with the LRO phase below the Almeida-Thouless (A-T) and Gabey-Toulouse (G-T) lines. It is shown that the temperature dependence of the integrated intensity of the antiferromagnetic (AFM) peak shows dips with respect to the Brillouin function behavior around the SG1 and SG2 transition temperatures. The temperature dependence of the unit cell volume departs from the Debye-Grüneisen behavior below the SG1 transition and the magnitude of departure increases significantly with decreasing temperature up to the electromagnon driven transition temperature below which a small change of slope occurs followed by another similar change of slope at the SG2 transition temperature. The ferroelectric polarization also changes significantly at the two spin-glass transition temperatures. These results, obtained using microscopic techniques, clearly demonstrate that the SG1 and SG2 transitions occur on the same magnetic sublattice and are intrinsic to the system. We also construct a phase diagram showing all

78 FR 50323 - Amendment of Class E Airspace; Lexington, OK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

...-0272; Airspace Docket No. 13-ASW-10] Amendment of Class E Airspace; Lexington, OK AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace at... Class E surface area to a Class E transition area. This action enhances the safety and management of...

Spectroscopy of the hydrogen 1 S -3 S transition with chirped laser pulses

NASA Astrophysics Data System (ADS)

Yost, D. C.; Matveev, A.; Grinin, A.; Peters, E.; Maisenbacher, L.; Beyer, A.; Pohl, R.; Kolachevsky, N.; Khabarova, K.; Hänsch, T. W.; Udem, Th.

2016-04-01

We identify a systematic present in two-photon direct frequency comb spectroscopy (DFCS) which is a result of chirped laser pulses and is a manifestation of the first-order Doppler effect. We carefully analyze this systematic and propose methods for its mitigation within the context of our measurement of the hydrogen 1 S -3 S transition. We also report on our determination of the absolute frequency of this transition, which is comparable to a previous measurement using continuous-wave spectroscopy [O. Arnoult et al., Eur. Phys. J. D 60, 243 (2010), 10.1140/epjd/e2010-00249-6], but was obtained with a different experimental method.

Flipping the Switch from G1 to S Phase with E3 Ubiquitin Ligases

PubMed Central

Rizzardi, Lindsay F.

2012-01-01

The cell cycle ensures genome maintenance by coordinating the processes of DNA replication and chromosome segregation. Of particular importance is the irreversible transition from the G1 phase of the cell cycle to S phase. This transition marks the switch from preparing chromosomes for replication (“origin licensing”) to active DNA synthesis (“origin firing”). Ubiquitin-mediated proteolysis is essential for restricting DNA replication to only once per cell cycle and is the major mechanism regulating the G1 to S phase transition. Although some changes in protein levels are attributable to regulated mRNA abundance, protein degradation elicits very rapid changes in protein abundance and is critical for the sharp and irreversible transition from one cell cycle stage to the next. Not surprisingly, regulation of the G1-to-S phase transition is perturbed in most cancer cells, and deregulation of key molecular events in G1 and S phase drives not only cell proliferation but also genome instability. In this review we focus on the mechanisms by which E3 ubiquitin ligases control the irreversible transition from G1 to S phase in mammalian cells. PMID:23634252

Analysis of the E2 transitions for /sup 3/H-/alpha/ cluster states of /sup 7/Li by the resonating group method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu Pu; Zhao Xuan; Zeng Fanan

1989-07-01

It is suggested that the ground state and the 1st, 2nd, and 3rd excited states of /sup 7/Li are /sup 3/H-/alpha/ cluster-structure states. Using the resonating group method (RGM), the eigenvalues and eigenfunctions of these states as well as the reduced E2 transition probabilities between these states are calculated and are consistent with the experimental values. The results show that the RGM is much better than the harmonic oscillator model used by Bernheim /ital et/ /ital al/. in predicting the E2 transition rates.

Observation of Upsilon(2S)-->etaUpsilon(1S) and search for related transitions.

PubMed

He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hunt, J M; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Ledoux, J; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Xavier, J V; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Libby, J; Martin, L; Powell, A; Wilkinson, G; Ecklund, K M; Love, W; Savinov, V; Mendez, H; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J

2008-11-07

We report the first observation of Upsilon(2S)-->etaUpsilon(1S), with a branching fraction B=(2.1(-0.6)+0.7(stat)+/-0.3(syst)) x 10(-4) and a statistical significance 5.3sigma. Data were acquired with the CLEO III detector at the CESR e+e(-) symmetric collider. This is the first process observed involving a b-quark spin flip. For related transitions, 90% confidence limits in units of 10(-4) are B(Upsilon(2S)-->pi0Upsilon(1S)) < 1.8, B(Upsilon(3S)-->etaUpsilon(1S)) < 1.8, B(Upsilon(3S)-->pi0Upsilon(1S)) < 0.7, and B(Upsilon(3S)-->pi0Upsilon(2S)) < 5.1.

Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.

PubMed

Gillis, L D; Lewis, S M

2013-08-01

eIF3e/Int6 is a component of the multi-subunit eIF3 complex, which binds directly to the 40S ribosome to facilitate ribosome recruitment to mRNA and hence protein synthesis. Reduced expression of eIF3e/Int6 has been found in up to 37% of human breast cancers, and expression of a truncated mutant version of the mouse eIF3e/Int6 protein leads to malignant transformation of normal mammary cells. These findings suggest that eIF3e/Int6 is a tumor suppressor; however, a recent study has reported that a reduction of eIF3e/Int6 expression in breast cancer cells leads to reduced translation of oncogenes, suggesting that eIF3e/Int6 may in fact have an oncogenic role in breast cancer. To gain a better understanding of the role of eIF3e/Int6 in breast cancer, we have examined the effects of decreased eIF3e/Int6 expression in an immortalized breast epithelial cell line, MCF-10A. Surprisingly, we find that decreased expression of eIF3e/Int6 causes breast epithelial cells to undergo epithelial-to-mesenchymal transition (EMT). We show that EMT induced by a decrease in eIF3e/Int6 expression imparts invasive and migratory properties to breast epithelial cells, suggesting that regulation of EMT by eIF3e/Int6 may have an important role in breast cancer metastasis. Furthermore, we show that reduced eIF3e/Int6 expression in breast epithelial cells causes a specific increase in the expression of the key EMT regulators Snail1 and Zeb2, which occurs at both the transcriptional and post-transcriptional levels. Together, our data indicate a novel role of eIF3e/Int6 in the regulation of EMT in breast epithelial cells and support a tumor suppressor role of eIF3e/Int6.

77 FR 4708 - Proposed Amendment of Class E Airspace; Tobe, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 [Amended] 2. The incorporation by reference... the southeast by V-263, and on the west by V-389. Issued in Seattle, Washington, on January 23, 2012...

Adolescents with Type 1 Diabetes: transition between diabetes services.

PubMed

Visentin, Kate; Koch, Tina; Kralik, Debbie

2006-06-01

The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents. The objectives were to: (1) involve key diabetes health delivery stakeholders in expressing their concerns and issues about current service delivery and ways to improve same, and (2) reveal from the perspective of the adolescents living with Type 1 Diabetes their experiences surrounding the process of transition. This paper presents research that sought to identify the major concerns and issues that stakeholders had about transition and to reveal the experience of transition for the adolescent with Type 1 Diabetes. Key representatives from seven public diabetes services in Adelaide, South Australia worked collaboratively to answer the objectives of this inquiry. Approach. Interview data were generated and analysed using a response focus framework provided by fourth generation evaluation research. In this study, the focus was on common concerns, claims and issues raised by health care professionals (n = 21) and adolescents (n = 10) aged between 15 and 18 years about transferring from children's to adult diabetes services. Data revealed education and dietetic advice was reactive rather than proactive and that the paediatric model of care is philosophically and practically different to the adult model of diabetes care. Three phases of transition were identified: preparation, formal transition and evaluation. Our findings indicated that these stages of transition were not being fully implemented in health units. The project findings have set the scene to establish a multidisciplinary working party to work collaboratively across agencies to develop effective transition pathways. The role of diabetes nurse educators and dietitians in South Australia is under-used throughout the transition process. Diabetes nurse educators are in an ideal position to prepare, coordinate and evaluate transitional processes.

40 CFR 59.1 - Final determinations under Section 183(e)(3)(C) of the CAA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... furniture coatings; (b) Aerospace coatings; (c) Shipbuilding and repair coatings; (d) Lithographic printing materials; (e) Letterpress printing materials; (f) Flexible packaging printing materials; (g) Flat wood... materials; and (p) Miscellaneous industrial adhesives. [73 FR 58491, Oct. 7, 2008] ...

HIFiRE-1 Turbulent Shock Boundary Layer Interaction - Flight Data and Computations (Postprint)

DTIC Science & Technology

2015-06-01

tte rs on o n Se pt em be r 1, 2 01 5 | h ttp :// ar c. ai aa .o rg | D O I: 1 0. 25 14 /6 .2 01 5- 26 39...characteristics of a transitional interaction at about this time. D ow nl oa de d by A FR L D ’A zz o W ri gh t- Pa tte rs on o n Se pt em be r 1, 2 01 5...endoatmospheric. The remainder of the trajectory was exoatmospheric. D ow nl oa de d by A FR L D ’A zz o W

Electrically controllable liquid crystal random lasers below the Fréedericksz transition threshold.

PubMed

Lee, Chia-Rong; Lin, Jia-De; Huang, Bo-Yuang; Lin, Shih-Hung; Mo, Ting-Shan; Huang, Shuan-Yu; Kuo, Chie-Tong; Yeh, Hui-Chen

2011-01-31

This investigation elucidates for the first time electrically controllable random lasers below the threshold voltage in dye-doped liquid crystal (DDLC) cells with and without adding an azo-dye. Experimental results show that the lasing intensities and the energy thresholds of the random lasers can be decreased and increased, respectively, by increasing the applied voltage below the Fréedericksz transition threshold. The below-threshold-electric-controllability of the random lasers is attributable to the effective decrease of the spatial fluctuation of the orientational order and thus of the dielectric tensor of LCs by increasing the electric-field-aligned order of LCs below the threshold, thereby increasing the diffusion constant and decreasing the scattering strength of the fluorescence photons in their recurrent multiple scattering. This can result in the decrease in the lasing intensity of the random lasers and the increase in their energy thresholds. Furthermore, the addition of an azo-dye in DDLC cell can induce the range of the working voltage below the threshold for the control of the random laser to reduce.

26 CFR 1.367(e)-0 - Outline of §§ 1.367(e)-1 and 1.367(e)-2.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 4 2011-04-01 2011-04-01 false Outline of §§ 1.367(e)-1 and 1.367(e)-2. 1.367(e)-0 Section 1.367(e)-0 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Effects on Corporation § 1.367(e)-0 Outline of §§ 1.367(e)-1...

Multi-band transit observations of the TrES-2b exoplanet

NASA Astrophysics Data System (ADS)

Mislis, D.; Schröter, S.; Schmitt, J. H. M. M.; Cordes, O.; Reif, K.

2010-02-01

We present a new data set of transit observations of the TrES-2b exoplanet taken in spring 2009, using the 1.2 m Oskar-Lühning telescope (OLT) of Hamburg Observatory and the 2.2 m telescope at Calar Alto Observatory using BUSCA (Bonn University Simultaneous CAmera). Both the new OLT data, taken with the same instrumental setup as our data taken in 2008, as well as the simultaneously recorded multicolor BUSCA data confirm the low inclination values reported previously, and in fact suggest that the TrES-2b exoplanet has already passed the first inclination threshold (imin,1 = 83.417°) and is not eclipsing the full stellar surface any longer. Using the multi-band BUSCA data we demonstrate that the multicolor light curves can be consistently fitted with a given set of limb darkening coefficients without the need to adjust these coefficients, and further, we can demonstrate that wavelength dependent stellar radius changes must be small as expected from theory. Our new observations provide further evidence for a change of the orbit inclination of the transiting extrasolar planet TrES-2b reported previously. We examine in detail possible causes for this inclination change and argue that the observed change should be interpreted as nodal regression. While the assumption of an oblate host star requires an unreasonably large second harmonic coefficient, the existence of a third body in the form of an additional planet would provide a very natural explanation for the observed secular orbit change. Given the lack of clearly observed short-term variations of transit timing and our observed secular nodal regression rate, we predict a period between approximately 50 and 100 days for a putative perturbing planet of Jovian mass. Such an object should be detectable with present-day radial velocity (RV) techniques, but would escape detection through transit timing variations. Photometric transit data are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr

76 FR 53967 - Carolina Power & Light, Shearon Harris Nuclear Power Plant, Unit 1; Notice of Consideration of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

... hearing and intervention via electronic submission through the NRC E-Filing system. Requests for a hearing... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... requirements of E-Filing, at least 10 days prior to the filing deadline, the participant should contact the...

Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells

PubMed Central

Saglam, Atiye Seda Yar; Alp, Ebru; Elmazoglu, Zubeyir; Menevse, Emine Sevda

2016-01-01

The activation of the phosphatidylinositol-3 kinase/v-akt murine thymoma viral oncogene homolog (Akt) and mitogen activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathways are implicated in the majority of cancers. Selective inhibition of Akt and ERK represents a potential approach for cancer therapy. Therefore, the present study aimed to investigate the apoptotic and anti-proliferative effects of the novel and selective Akt inhibitor 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide (API-1) and selective ERK1/2 inhibitor FR180204 (FR) alone and in combination on colorectal cancer (CRC) cells (DLD-1 and LoVo). In addition, the effects of API-1 and FR on Akt and ERK signaling pathways were also investigated. The effects of the agents on DLD-1 and LoVo cells were evaluated in terms of cell viability, cytotoxicity, DNA synthesis rate, DNA fragmentation and caspase-3 activity levels. In addition, quantitative reverse transcription-polymerase chain reaction and western blot analysis were performed to examine relevant mRNA and protein levels. The present study observed that the combination of FR with API-1 resulted in significant apoptosis and cytotoxicity compared with any single agent alone in a time-dependent manner in these cells. Also, treatment with FR and API-1 in combination decreased the expression levels of B-cell lymphoma-2 (BCL2), Bcl-2-like1, cyclin D1 and cMYC, and increased the expression levels of BCL2-associated X protein and BCL2 antagonist/killer via phosphorylated Akt and phosphorylated ERK1/2 downregulation. The combination of Akt and ERK1/2 inhibitors resulted in enhanced apoptotic and anti-proliferative effects against CRC cells. The present study hypothesizes that the combination of FR and API-1 in CRC cells may contribute toward potential anti-carcinogenic effects. Additional analyses using other cancer cell lines and animal models are required to confirm these findings in vitro and in

Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells.

PubMed

Saglam, Atiye Seda Yar; Alp, Ebru; Elmazoglu, Zubeyir; Menevse, Emine Sevda

2016-10-01

The activation of the phosphatidylinositol-3 kinase/v-akt murine thymoma viral oncogene homolog (Akt) and mitogen activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathways are implicated in the majority of cancers. Selective inhibition of Akt and ERK represents a potential approach for cancer therapy. Therefore, the present study aimed to investigate the apoptotic and anti-proliferative effects of the novel and selective Akt inhibitor 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide (API-1) and selective ERK1/2 inhibitor FR180204 (FR) alone and in combination on colorectal cancer (CRC) cells (DLD-1 and LoVo). In addition, the effects of API-1 and FR on Akt and ERK signaling pathways were also investigated. The effects of the agents on DLD-1 and LoVo cells were evaluated in terms of cell viability, cytotoxicity, DNA synthesis rate, DNA fragmentation and caspase-3 activity levels. In addition, quantitative reverse transcription-polymerase chain reaction and western blot analysis were performed to examine relevant mRNA and protein levels. The present study observed that the combination of FR with API-1 resulted in significant apoptosis and cytotoxicity compared with any single agent alone in a time-dependent manner in these cells. Also, treatment with FR and API-1 in combination decreased the expression levels of B-cell lymphoma-2 (BCL2), Bcl-2-like1, cyclin D1 and cMYC, and increased the expression levels of BCL2-associated X protein and BCL2 antagonist/killer via phosphorylated Akt and phosphorylated ERK1/2 downregulation. The combination of Akt and ERK1/2 inhibitors resulted in enhanced apoptotic and anti-proliferative effects against CRC cells. The present study hypothesizes that the combination of FR and API-1 in CRC cells may contribute toward potential anti-carcinogenic effects. Additional analyses using other cancer cell lines and animal models are required to confirm these findings in vitro and in

Quasiperiodic Quantum Ising Transitions in 1D

NASA Astrophysics Data System (ADS)

Crowley, P. J. D.; Chandran, A.; Laumann, C. R.

2018-04-01

Unlike random potentials, quasiperiodic modulation can induce localization-delocalization transitions in one dimension. In this Letter, we analyze the implications of this for symmetry breaking in the quasiperiodically modulated quantum Ising chain. Although weak modulation is irrelevant, strong modulation induces new ferromagnetic and paramagnetic phases which are fully localized and gapless. The quasiperiodic potential and localized excitations lead to quantum criticality that is intermediate to that of the clean and randomly disordered models with exponents of ν =1+ (exact) and z ≈1.9 , Δσ≈0.16 , and Δγ≈0.63 (up to logarithmic corrections). Technically, the clean Ising transition is destabilized by logarithmic wandering of the local reduced couplings. We conjecture that the wandering coefficient w controls the universality class of the quasiperiodic transition and show its stability to smooth perturbations that preserve the quasiperiodic structure of the model.

A Correlation-Based Transition Model using Local Variables. Part 1; Model Formation

NASA Technical Reports Server (NTRS)

Menter, F. R.; Langtry, R. B.; Likki, S. R.; Suzen, Y. B.; Huang, P. G.; Volker, S.

2006-01-01

A new correlation-based transition model has been developed, which is based strictly on local variables. As a result, the transition model is compatible with modern computational fluid dynamics (CFD) approaches, such as unstructured grids and massive parallel execution. The model is based on two transport equations, one for intermittency and one for the transition onset criteria in terms of momentum thickness Reynolds number. The proposed transport equations do not attempt to model the physics of the transition process (unlike, e.g., turbulence models) but from a framework for the implementation of correlation-based models into general-purpose CFD methods.

Origin of field-induced discontinuous phase transitions in N d2F e17

NASA Astrophysics Data System (ADS)

Diop, L. V. B.; Kuz'min, M. D.; Skokov, K. P.; Skourski, Y.; Gutfleisch, O.

2018-02-01

Magnetic properties of a trigonal ferromagnet N d2F e17 have been studied on single crystals in steady (14 T) and pulsed (32 T) magnetic fields. The easy-magnetization direction lies close to the [120] axis, deviating from the basal plane by 2 .9∘ (at T =5 K ). Of particular interest is the low-temperature magnetization process along the high-symmetry axis [001], which is the hard direction. This process is discontinuous and involves two first-order phase transitions (FOMPs). One of them (at 20 T) is a symmetry FOMP similar to that observed in S m2F e17 . The second transition (at 10.4 T) is unusual: as the magnetization turns abruptly toward the applied field, it also changes its azimuthal orientation (the angle φ ) by 60∘. Both transitions can be reasonably accounted for by the presence of a significant sixth-order trigonal anisotropy term.

The three-dimensional locomotor dynamics of African (Loxodonta africana) and Asian (Elephas maximus) elephants reveal a smooth gait transition at moderate speed

PubMed Central

Ren, Lei; Hutchinson, John R

2007-01-01

We examined whether elephants shift to using bouncing (i.e. running) mechanics at any speed. To do this, we measured the three-dimensional centre of mass (CM) motions and torso rotations of African and Asian elephants using a novel multisensor method. Hundreds of continuous stride cycles were recorded in the field. African and Asian elephants moved very similarly. Near the mechanically and metabolically optimal speed (a Froude number (Fr) of 0.09), an inverted pendulum mechanism predominated. With increasing speed, the locomotor dynamics quickly but continuously became less like vaulting and more like bouncing. Our mechanical energy analysis of the CM suggests that at a surprisingly slow speed (approx. 2.2 m s−1, Fr 0.25), the hindlimbs exhibited bouncing, not vaulting, mechanics during weight support. We infer that a gait transition happens at this relatively slow speed: elephants begin using their compliant hindlimbs like pogo sticks to some extent to drive the body, bouncing over their relatively stiff, vaulting forelimbs. Hence, they are not as rigid limbed as typically characterized for graviportal animals, and use regular walking as well as at least one form of running gait. PMID:17594960

CYP2E1 Metabolism of Styrene Involves Allostery

PubMed Central

Hartman, Jessica H.; Boysen, Gunnar

2012-01-01

We are the first to report allosterism during styrene oxidation by recombinant CYP2E1 and human liver microsomes. At low styrene concentrations, oxidation is inefficient because of weak binding to CYP2E1 (Ks = 830 μM). A second styrene molecule then binds CYP2E1 with higher affinity (Kss = 110 μM) and significantly improves oxidation to achieve a kcat of 6.3 nmol · min−1 · nmol CYP2E1−1. The transition between these metabolic cycles coincides with reported styrene concentrations in blood from exposed workers; thus, this CYP2E1 mechanism may be relevant in vivo. Scaled modeling of the in vitro-positive allosteric mechanism for styrene metabolism to its in vivo clearance led to significant deviations from the traditional model based on Michaelis-Menten kinetics. Low styrene levels were notably much less toxic than generally assumed. We interrogated the allosteric mechanism using the CYP2E1-specific inhibitor and drug 4-methylpyrazole, which we have shown binds two CYP2E1 sites. From the current studies, styrene was a positive allosteric effector on 4-methylpyrazole binding, based on a 10-fold increase in 4-methylpyrazole binding affinity from Ki 0.51 to Ksi 0.043 μM. The inhibitor was a negative allosteric effector on styrene oxidation, because kcat decreased 6-fold to 0.98 nmol · min−1 · nmol CYP2E1−1. Consequently, mixtures of styrene and other molecules can induce allosteric effects on binding and metabolism by CYP2E1 and thus mitigate the efficiency of their metabolism and corresponding effects on human health. Taken together, our elucidation of mechanisms for these allosteric reactions provides a powerful tool for further investigating the complexities of CYP2E1 metabolism of drugs and pollutants. PMID:22807108

Structural transitions in Pb(In 1/2Nb 1/2)O 3 under pressure

DOE PAGES

Ahart, Muhtar; Somayazulu, Maddury; Kojima, Seiji; ...

2015-12-01

Here, Raman scattering, x-ray diffraction, and first-principles calculations were employed to investigate the behavior of disordered Pb(In 1/2Nb 1/2)O 3 (PIN) under pressure up to 50 GPa. The experiments were performed at room temperature while ab-initio calculations were carried out at 0 K. Raman spectra for disordered PIN show broad bands but a peak near the 380 cm -1 increases its intensity with pressure. The linewidth of the band at 550 cm -1 also increases with pressure, while two of the Raman peaks merge above 6 GPa. Above 16 GPa, we observe additional splitting of the band at 50 cmmore » -1. The pressure evolution of the diffraction patterns for PIN shows obvious splitting for Bragg peaks above 16 GPa; the results indicate a possible lowering symmetry transition. We identified that the transition at 0.5 GPa is from pseudo-cubic to orthorhombic (Pbam), the transitions at 16 GPa are isostructure transitions due to changes in linear compressibility and octahedral titling, and the transition at 30 GPa is from orthorhombic to monoclinic. First-principles calculations results indicated that ground state is Pbam with antiferrodisdortion consistent with experiment.« less

Ghosts of Milky Way's past: the globular cluster ESO 37-1 (E 3)

NASA Astrophysics Data System (ADS)

de la Fuente Marcos, R.; de la Fuente Marcos, C.; Moni Bidin, C.; Ortolani, S.; Carraro, G.

2015-09-01

Context. In the Milky Way, most globular clusters are highly conspicuous objects that were found centuries ago. However, a few dozen of them are faint, sparsely populated systems that were identified largely during the second half of the past century. One of the faintest is ESO 37-1 (E 3) and as such it remains poorly studied, with no spectroscopic observations published so far although it was discovered in 1976. Aims: We investigate the globular cluster E 3 in an attempt to better constrain its fundamental parameters. Spectroscopy of stars in the field of E 3 is shown here for the first time. Methods: Deep, precise VI CCD photometry of E 3 down to V ~ 26 mag is presented and analysed. Low-resolution, medium signal-to-noise ratio spectra of nine candidate members are studied to derive radial velocity and metallicity. Proper motions from the UCAC4 catalogue are used to explore the kinematics of the bright members of E 3. Results: Isochrone fitting indicates that E 3 is probably very old, with an age of about 13 Gyr; its distance from the Sun is nearly 10 kpc. It is also somewhat metal rich with [Fe/H] = -0.7. Regarding its kinematics, our tentative estimate for the proper motions is (μα cosδ,μδ) = (-7.0 ± 0.8, 3.5 ± 0.3) mas yr-1 (or a tangential velocity of 382 ± 79 km s-1) and for the radial velocity 45 ± 5 km s-1 in the solar rest frame. Conclusions: E 3 is one of the most intriguing globular clusters in the Galaxy. Having an old age and being metal rich is clearly a peculiar combination, only seen in a handful of objects like the far more conspicuous NGC 104 (47 Tucanae). In addition, its low luminosity and sparse population make it a unique template for the study of the final evolutionary phases in the life of a star cluster. Unfortunately, E 3 is among the most elusive and challenging known globular clusters because field contamination severely hampers spectroscopic studies. This research note is based on observations made with the ESO VLT at the

One-phonon octupole vibrational states in 211At, 212Rn, 213Fr and 214Ra with N = 126

NASA Astrophysics Data System (ADS)

Hwang, J. K.; Hamilton, J. H.; Ramayya, A. V.

2013-12-01

Excited high spin states in 211At, 212Rn, 213Fr and 214Ra with N = 126 are reorganized and interpreted in terms of the stretched weak coupling of an octupole 3- phonon. Nearly identical sequences of levels with ΔI = 3 and the parity change are found, for the first time, up to 25- for 20 states of 214Ra, up to 35- for 36 states of 212Rn and up to 53/2+ for 16 states of 213Fr. The stretched weak coupling of an octupole phonon is extended up to the highest excitation energy of 11355 keV for 212Rn which has the largest experimental B( E3) value of 44.1(88) W.u. for the 11- → 8{2/+} transition. The stretched weak coupling of an octupole 3- phonon needs to be considered when single particle configurations are assigned to high spin states. Average octupole excitation energies of 657(51) keV for 211At, 1101(28) keV for 212Rn, 667(25) keV for 213Fr, and 709(25) keV for 214Ra are obtained. The calculated level enegies are in a good agreement with the experimental level energies within the error limit of 4.3%.

Forward-facing steps induced transition in a subsonic boundary layer

NASA Astrophysics Data System (ADS)

Zh, Hui; Fu, Song

2017-10-01

A forward-facing step (FFS) immersed in a subsonic boundary layer is studied through a high-order flux reconstruction (FR) method to highlight the flow transition induced by the step. The step height is a third of the local boundary-layer thickness. The Reynolds number based on the step height is 720. Inlet disturbances are introduced giving rise to streamwise vortices upstream of the step. It is observed that these small-scale streamwise structures interact with the step and hairpin vortices are quickly developed after the step leading to flow transition in the boundary layer.

Rational approximations of f(R) cosmography through Pad'e polynomials

NASA Astrophysics Data System (ADS)

Capozziello, Salvatore; D'Agostino, Rocco; Luongo, Orlando

2018-05-01

We consider high-redshift f(R) cosmography adopting the technique of polynomial reconstruction. In lieu of considering Taylor treatments, which turn out to be non-predictive as soon as z>1, we take into account the Pad&apose rational approximations which consist in performing expansions converging at high redshift domains. Particularly, our strategy is to reconstruct f(z) functions first, assuming the Ricci scalar to be invertible with respect to the redshift z. Having the so-obtained f(z) functions, we invert them and we easily obtain the corresponding f(R) terms. We minimize error propagation, assuming no errors upon redshift data. The treatment we follow naturally leads to evaluating curvature pressure, density and equation of state, characterizing the universe evolution at redshift much higher than standard cosmographic approaches. We therefore match these outcomes with small redshift constraints got by framing the f(R) cosmology through Taylor series around 0zsimeq . This gives rise to a calibration procedure with small redshift that enables the definitions of polynomial approximations up to zsimeq 10. Last but not least, we show discrepancies with the standard cosmological model which go towards an extension of the ΛCDM paradigm, indicating an effective dark energy term evolving in time. We finally describe the evolution of our effective dark energy term by means of basic techniques of data mining.

Size-dependent structural transformations of hematite nanoparticles. 1. Phase transition.

PubMed

Chernyshova, I V; Hochella, M F; Madden, A S

2007-04-14

Using Fourier Transform InfraRed (FTIR) spectroscopy, Raman spectroscopy, X-ray diffraction (XRD), and Transmission Electron Microscopy (TEM), we characterize the structure and/or morphology of hematite (alpha-Fe(2)O(3)) particles with sizes of 7, 18, 39 and 120 nm. It is found that these nanoparticles possess maghemite (gamma-Fe(2)O(3))-like defects in the near surface regions, to which a vibrational mode at 690 cm(-1), active both in FTIR and Raman spectra, is assigned. The fraction of the maghemite-like defects and the net lattice disorder are inversely related to the particle size. However, the effect is opposite for nanoparticles grown by sintering of smaller hematite precursors under conditions when the formation of a uniform hematite-like structure throughout the aggregate is restricted by kinetic issues. This means that not only particle size but also the growth kinetics determines the structure of the nanoparticles. The observed structural changes are interpreted as size-induced alpha-Fe(2)O(3)<-->gamma-Fe(2)O(3) phase transitions. We develop a general model that considers spinel defects and absorbed/adsorbed species (in our case, hydroxyls) as dominant controls on structural changes with particle size in hematite nanoparticles, including solid-state phase transitions. These changes are represented by trajectories in a phase diagram built in three phase coordinates-concentrations of spinel defects, absorbed impurities, and adsorbed species. The critical size for the onset of the alpha-->gamma phase transition depends on the particle environment, and for the dry particles used in this study is about 40 nm. The model supports the existence of intermediate phases (protohematite and hydrohematite) during dehydration of goethite. We also demonstrate that the hematite structure is significantly less defective when the nanoparticles are immersed in water or KBr matrix, which is explained by the effects of the electrochemical double layer and increased rigidity of

47 CFR 27.1231 - Initiating the transition.

Code of Federal Regulations, 2011 CFR

2011-10-01

... address, and phone and fax numbers. (1) BRS and EBS licensees that receive a Pre-Transition Data Request... Data Request (see paragraph (d) of this section) and a Transition Notice (see paragraph (e) of this... accept a co-proponent at its sole discretion. (d) Pre-Transition Data Request. The Pre-Transition Data...

Ground-based transit observations of the super-Earth GJ 1214 b

NASA Astrophysics Data System (ADS)

Cáceres, C.; Kabath, P.; Hoyer, S.; Ivanov, V. D.; Rojo, P.; Girard, J. H.; Miller-Ricci Kempton, E.; Fortney, J. J.; Minniti, D.

2014-05-01

Context. GJ 1214 b is one of the few known transiting super-Earth-sized exoplanets with a measured mass and radius. It orbits an M-dwarf, only 14.55 pc away, making it a favorable candidate for follow-up studies. However, the composition of GJ 1214 b's mysterious atmosphere has yet to be fully unveiled. Aims: Our goal is to distinguish between the various proposed atmospheric models to explain the properties of GJ 1214 b: hydrogen-rich or hydrogen-He mix, or a heavy molecular weight atmosphere with reflecting high clouds, as latest studies have suggested. Methods: Wavelength-dependent planetary radii measurements from the transit depths in the optical/NIR are the best tool to investigate the atmosphere of GJ 1214 b. We present here (i) photometric transit observations with a narrow-band filter centered on 2.14 μm and a broad-band I-Bessel filter centered on 0.8665 μm, and (ii) transmission spectroscopy in the H and K atmospheric windows that cover three transits. The photometric and spectrophotometric time series obtained were analyzed with MCMC simulations to measure the planetary radii as a function of wavelength. We determined radii ratios of 0.1173-0.0024+0.0022 for I-Bessel and 0.11735-0.00076+0.00072 at 2.14 μm. Results: Our measurements indicate a flat transmission spectrum, in agreement with the last atmospheric models that favor featureless spectra with clouds and high molecular weight compositions. Based on observations obtained at the Southern Astrophysical Research (SOAR) Telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the US National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU). SofI results are based on observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 087.C-0509.Tables of the lightcurve data are only available at the CDS via anonymous

Departure from the constant-period ephemeris for the transiting exoplanet WASP-12

NASA Astrophysics Data System (ADS)

Maciejewski, G.; Dimitrov, D.; Fernández, M.; Sota, A.; Nowak, G.; Ohlert, J.; Nikolov, G.; Bukowiecki, Ł.; Hinse, T. C.; Pallé, E.; Tingley, B.; Kjurkchieva, D.; Lee, J. W.; Lee, C.-U.

2016-04-01

Aims: Most hot Jupiters are expected to spiral in toward their host stars because the angular momentum of the orbital motion is transferred to the stellar spin. Their orbits can also precess as a result of planet-star interactions. Calculations show that both effects might be detected for the very-hot exoplanet WASP-12 b using the method of precise transit-timing over a time span of about 10 yr. Methods: We acquired new precise light curves for 29 transits of WASP-12 b, spannning four observing seasons from November 2012 to February 2016. New mid-transit times, together with those from the literature, were used to refine the transit ephemeris and analyze the timing residuals. Results: We find that the transit times of WASP-12 b do not follow a linear ephemeris with a 5σ confidence level. They may be approximated with a quadratic ephemeris that gives a change rate in the orbital period of (-2.56 ± 0.40) × 10-2 s yr-1. The tidal quality parameter of the host star was found to be equal to 2.5 × 105, which is similar to theoretical predictions for Sun-like stars. We also considered a model in which the observed timing residuals are interpreted as a result of the apsidal precession. We find, however, that this model is statistically less probable than the orbital decay. Partly based on (1) data collected with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, (2) observations made at the Centro Astronómico Hispano Alemán (CAHA), operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC), and (3) data collected with telescopes at the Rozhen National Astronomical Observatory.The light curves are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/588/L

An RGDS peptide-binding receptor, FR-1R, localizes to the basal side of the ectoderm and to primary mesenchyme cells in sand dollar embryos.

PubMed

Katow, H; Sofuku, S

2001-10-01

Immunoblotting using polyclonal antibodies (pAb) raised against an FR-1 receptor (FR-1R), a 57 kDa Arg-Gly-Asp-Ser (RGDS)-binding protein, of the sand dollar Clypeaster japonicus showed that the pAb monospecifically bound to the protein. FR-1R was present in purified plasma membrane, suggesting that the protein is a membrane-bound protein. The molecular structure of FR-1R did not change throughout the early embryogenesis, whereas its expression changed significantly during this period. FR-1R was present in the cortex of unfertilized eggs and was then transferred to the hyaline layer soon after the fertilization. The hyaline layer retained FR-1R immunoreactivity during early embryogenesis. FR-1R appeared on the basal side of the ectoderm at the morula stage and was retained basolaterally, at least, to the early gastrula stage. In mesenchyme blastulae, FR-1R was also present on the surface of primary mesenchyme cells (PMC). FR-1R was localized on the basal side of the ectoderm in early gastrulae, exclusively at the place where PMC formed ventrolateral aggregates, and at the apical tuft ectoderm. In vitro, PMC bound to FR-1R and its binding was inhibited in the presence of a synthetic RGDS peptide or the pAb. The pAb introduced into the blastocoele perturbed PMC migration and gastrulation. FR-1R was weakly recognized by antihuman integrin beta5 subunit pAb.

Chimaphilin inhibits human osteosarcoma cell invasion and metastasis through suppressing the TGF-β1-induced epithelial-to-mesenchymal transition markers via PI-3K/Akt, ERK1/2, and Smad signaling pathways.

PubMed

Dong, Feng; Liu, Tingting; Jin, Hao; Wang, Wenbo

2018-01-01

Epithelial-to-mesenchymal transition is a cellular process associated with cancer invasion and metastasis. However, the antimetastatic effects of chimaphilin remain elusive. In this study, we attempted to investigate the potential use of chimaphilin as an inhibitor of TGF-β1-induced epithelial-to-mesenchymal transition in U2OS cells. We found that TGF-β1 induced epithelial-to-mesenchymal transition to promote U2OS cell invasion and metastasis. Western blotting demonstrated that chimaphilin inhibited U2OS cell invasion and migration, increased the expression of the epithelial phenotype marker E-cadherin, repressed the expression of the mesenchymal phenotype marker vimentin, as well as decreased the level of epithelial-to-mesenchymal-inducing transcription factors Snail1 and Slug during the initiation of TGF-β1-induced epithelial-to-mesenchymal transition. In this study, we revealed that chimaphilin up-regulated the E-cadherin expression level and inhibited the production of vimentin, Snail1, and Slug in TGF-β1-induced U2OS cells by blocking PI-3K/Akt and ERK 1/2 signaling pathway. Additionally, the TGF-β1-mediated phosphorylated levels of Smad2/3 were inhibited by chimaphilin pretreatment. Above all, we conclude that chimaphilin represents an effective inhibitor of the metastatic potential of U2OS cells through suppression of TGF-β1-induced epithelial-to-mesenchymal transition.

Simultaneous multicolour optical and near-IR transit photometry of GJ 1214b with SOFIA

NASA Astrophysics Data System (ADS)

Angerhausen, D.; Dreyer, C.; Placek, B.; Csizmadia, Sz.; Eigmüller, Ph.; Godolt, M.; Kitzmann, D.; Mallonn, M.; Becklin, E. E.; Collins, P.; Dunham, E. W.; Grenfell, J. L.; Hamilton, R. T.; Kabath, P.; Logsdon, S. E.; Mandell, A.; Mandushev, G.; McElwain, M.; McLean, I. S.; Pfueller, E.; Rauer, H.; Savage, M.; Shenoy, S.; Vacca, W. D.; Van Cleve, J. E.; Wiedemann, M.; Wolf, J.

2017-12-01

Context. The benchmark exoplanet GJ 1214b is one of the best studied transiting planets in the transition zone between rocky Earth-sized planets and gas or ice giants. This class of super-Earth or mini-Neptune planets is unknown in our solar system, yet is one of the most frequently detected classes of exoplanets. Understanding the transition from rocky to gaseous planets is a crucial step in the exploration of extrasolar planetary systems, in particular with regard to the potential habitability of this class of planets. Aims: GJ 1214b has already been studied in detail from various platforms at many different wavelengths. Our airborne observations with the Stratospheric Observatory for Infrared Astronomy (SOFIA) add information in the Paschen-α cont. 1.9 μm infrared wavelength band, which is not accessible by any other current ground- or space-based instrument due to telluric absorption or limited spectral coverage. Methods: We used FLIPO, the combination of the High-speed Imaging Photometer for Occultations (HIPO) and the First Light Infrared TEst CAMera (FLITECAM) and the Focal Plane Imager (FPI+) on SOFIA to comprehensively analyse the transmission signal of the possible water-world GJ 1214b through photometric observations during transit in three optical and one infrared channels. Results: We present four simultaneous light curves and corresponding transit depths in three optical and one infrared channel, which we compare to previous observations and current synthetic atmospheric models of GJ 1214b. The final precision in transit depth is between 1.5 and 2.5 times the theoretical photon noise limit, not sensitive enough to constrain the theoretical models any better than previous observations. This is the first exoplanet observation with SOFIA that uses its full set of instruments available to exoplanet spectrophotometry. Therefore we use these results to evaluate SOFIA's potential in this field and suggest future improvements. Tables of the lightcurve data

NGTS-1b: a hot Jupiter transiting an M-dwarf

NASA Astrophysics Data System (ADS)

Bayliss, Daniel; Gillen, Edward; Eigmüller, Philipp; McCormac, James; Alexander, Richard D.; Armstrong, David J.; Booth, Rachel S.; Bouchy, François; Burleigh, Matthew R.; Cabrera, Juan; Casewell, Sarah L.; Chaushev, Alexander; Chazelas, Bruno; Csizmadia, Szilard; Erikson, Anders; Faedi, Francesca; Foxell, Emma; Gänsicke, Boris T.; Goad, Michael R.; Grange, Andrew; Günther, Maximilian N.; Hodgkin, Simon T.; Jackman, James; Jenkins, James S.; Lambert, Gregory; Louden, Tom; Metrailler, Lionel; Moyano, Maximiliano; Pollacco, Don; Poppenhaeger, Katja; Queloz, Didier; Raddi, Roberto; Rauer, Heike; Raynard, Liam; Smith, Alexis M. S.; Soto, Maritza; Thompson, Andrew P. G.; Titz-Weider, Ruth; Udry, Stéphane; Walker, Simon R.; Watson, Christopher A.; West, Richard G.; Wheatley, Peter J.

2018-04-01

We present the discovery of NGTS-1b, a hot Jupiter transiting an early M-dwarf host (Teff,* = 3916 ^{+71}_{-63} K) in a P = 2.647 d orbit discovered as part of the Next Generation Transit Survey (NGTS). The planet has a mass of 0.812 ^{+0.066}_{-0.075} MJ, making it the most massive planet ever discovered transiting an M-dwarf. The radius of the planet is 1.33 ^{+0.61}_{-0.33} RJ. Since the transit is grazing, we determine this radius by modelling the data and placing a prior on the density from the population of known gas giant planets. NGTS-1b is the third transiting giant planet found around an M-dwarf, reinforcing the notion that close-in gas giants can form and migrate similar to the known population of hot Jupiters around solar-type stars. The host star shows no signs of activity, and the kinematics hint at the star being from the thick disc population. With a deep (2.5 per cent) transit around a K = 11.9 host, NGTS-1b will be a strong candidate to probe giant planet composition around M-dwarfs via James Webb Space Telescope transmission spectroscopy.

E-Mobility and the Energy Transition.

PubMed

Schlögl, Robert

2017-09-04

Since the reduction of greenhouse gases is the top priority of the Energy Transition, primary electricity should be converted to material energy carriers. In this way electricity can be "stored" and made accessible for other applications. This Essay focuses on the integration of mobility in the Energy Transition and the development of sustainable alternatives to electricity-based transportation. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes.

PubMed

Wu, Jiangbin; Lv, Qing; He, Jie; Zhang, Haoxiang; Mei, Xueshuang; Cui, Kai; Huang, Nunu; Xie, Weidong; Xu, Naihan; Zhang, Yaou

2014-10-11

Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating cell cycle machinery. It has been shown that miR-188 is upregulated in UVB-irradiated mouse skin and human nasopharyngeal carcinoma CNE cells under hypoxic stress. However, little is known about the function of miR-188 in cell proliferation and growth control. Overexpression of miR-188 inhibits cell proliferation, tumor colony formation and G1/S cell cycle transition in human nasopharyngeal carcinoma CNE cells. Using bioinformatics approach, we identify a series of genes regulating G1/S transition as putative miR-188 targets. MiR-188 inhibits both mRNA and protein expression of CCND1, CCND3, CCNE1, CCNA2, CDK4 and CDK2, suppresses Rb phosphorylation and downregulates E2F transcriptional activity. The expression level of miR-188 also inversely correlates with the expression of miR-188 targets in human nasopharyngeal carcinoma (NPC) tissues. Moreover, studies in xenograft mouse model reveal that miR-188 is capable of inhibiting tumor initiation and progression by suppressing target genes expression and Rb phosphorylation. This study demonstrates that miR-188 exerts anticancer effects, via downregulation of multiple G1/S related cyclin/CDKs and Rb/E2F signaling pathway.

76 FR 53970 - Carolina Power & Light; Brunswick Steam Electric Plant, Units 1 and 2; Independent Spent Fuel...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

... submission through the NRC E-Filing system. Requests for a hearing and petitions for leave to intervene... participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory documents...

Trichomonas vaginalis Flavin Reductase 1 and its Role in Metronidazole Resistance

PubMed Central

Leitsch, David; Janssen, Brian D.; Kolarich, Daniel; Johnson, Patricia J.; Duchêne, Michael

2015-01-01

Summary The enzyme flavin reductase 1 (FR1) from Trichomonas vaginalis, formerly known as NADPH oxidase, was isolated and identified. Flavin reductase is part of the antioxidative defense in T. vaginalis and indirectly reduces molecular oxygen to hydrogen peroxide via free flavins. Importantly, a reduced or absent flavin reductase activity has been reported in metronidazole-resistant T. vaginalis, resulting in elevated intracellular oxygen levels and futile cycling of metronidazole. Interestingly, FR1 has no close homologue in any other sequenced genome, but seven full-length and three truncated isoforms exist in the T. vaginalis genome. However, out of these, only FR1 has an affinity for flavins, i.e. FMN, FAD, and riboflavin, which is high enough to be of physiological relevance. Although there are no relevant changes in the gene sequence or any alterations of the predicted FR1-mRNA structure in any of the strains studied, FR1 is not expressed in highly metronidazole-resistant strains. Transfection of a metronidazole-resistant clinical isolate (B7268), which does not express any detectable amounts of FR, with a plasmid bearing a functional FR1 gene nearly completely restored metronidazole sensitivity. Our results indicate that FR1 has a significant role in the emergence of metronidazole resistance in T. vaginalis. PMID:24256032

76 FR 77302 - Federal Transit Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... reduce the energy consumption or greenhouse gas emissions of public transportation systems. The Clean... DEPARTMENT OF TRANSPORTATION Federal Transit Administration FY 2011 Discretionary Sustainability...: The U.S. Department of Transportation's (DOT) Federal Transit Administration (FTA) announces the...

E-H mode transition of a high-power inductively coupled plasma torch at atmospheric pressure with a metallic confinement tube

NASA Astrophysics Data System (ADS)

Altenberend, Jochen; Chichignoud, Guy; Delannoy, Yves

2012-08-01

Inductively coupled plasma torches need high ignition voltages for the E-H mode transition and are therefore difficult to operate. In order to reduce the ignition voltage of an RF plasma torch with a metallic confinement tube the E-H mode transition was studied. A Tesla coil was used to create a spark discharge and the E-H mode transition of the plasma was then filmed using a high-speed camera. The electrical potential of the metallic confinement tube was measured using a high-voltage probe. It was found that an arc between the grounded injector and the metallic confinement tube is maintained by the electric field (E-mode). The transition to H-mode occurred at high magnetic fields when the arc formed a loop. The ignition voltage could be reduced by connecting the metallic confinement tube with a capacitor to the RF generator.

Photometric Analysis and Transit Times of TRAPPIST-1 B and C

NASA Astrophysics Data System (ADS)

Morris, Brett M.; Agol, Eric; Hawley, Suzanne L.

2018-01-01

TRAPPIST-1 hosts seven Earth-sized planets transiting an M8 star. We observed mid-transit times of each of the inner two planets with the Astrophysical Research Consortium (ARC) 3.5 m Telescope at Apache Point Observatory (APO) to help constrain the planet masses with transit timing variations, and we outline a procedure for analyzing transit observations of late-M stars with APO. The transit times of TRAPPIST-1 b and c are $\\mathrm{BJD}_{\\mathrm{TDB}} = 2457580.87634^{+0.00034}_{-0.00034}$ and $2457558.89477^{+0.00080}_{-0.00085}$, respectively, which will help constrain the planet masses.

26 CFR 1.860A-1 - Effective dates and transition rules.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Effective dates and transition rules. 1.860A-1 Section 1.860A-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Real Estate Investment Trusts § 1.860A-1 Effective dates and...

26 CFR 1.860A-1 - Effective dates and transition rules.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Effective dates and transition rules. 1.860A-1 Section 1.860A-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Real Estate Investment Trusts § 1.860A-1 Effective dates and...

26 CFR 1.860A-1 - Effective dates and transition rules.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Effective dates and transition rules. 1.860A-1 Section 1.860A-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Real Estate Investment Trusts § 1.860A-1 Effective dates and...

26 CFR 1.860A-1 - Effective dates and transition rules.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Effective dates and transition rules. 1.860A-1 Section 1.860A-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Real Estate Investment Trusts § 1.860A-1 Effective dates and...

Spin dependence of intra-ground-state-band E2 transitions in the SU(3) limit of the sdg interacting boson model

NASA Astrophysics Data System (ADS)

Long, G. L.; Ji, H. Y.

1998-04-01

B(E2, L+2-->L) transitions in the sdg interacting boson model SU(3) limit are studied with a general E2 transition operator. Analytical expressions are obtained using a group theoretic method. It is found that when using transition operators of the form (d†g~+g†d~)2 or (g†g~)2, the B(E2, L+2-->L) values in the ground-state band have an L(L+3) dependent term. As L increases, the B(E2) values can be larger than the rigid rotor model value. Application to 236,238U is discussed.

Sox5 induces epithelial to mesenchymal transition by transactivation of Twist1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pei, Xin-Hong; Department of Pathology, The Basic Medical College of Zhengzhou University, Zhengzhou, Henan; Lv, Xin-Quan

2014-03-28

Highlights: • Depletion of Sox5 inhibits breast cancer proliferation, migration, and invasion. • Sox5 transactivates Twist1 expression. • Sox5 induces epithelial to mesenchymal transition through transactivation of Twist1 expression. - Abstract: The epithelial to mesenchymal transition (EMT), a highly conserved cellular program, plays an important role in normal embryogenesis and cancer metastasis. Twist1, a master regulator of embryonic morphogenesis, is overexpressed in breast cancer and contributes to metastasis by promoting EMT. In exploring the mechanism underlying the increased Twist1 in breast cancer cells, we found that the transcription factor SRY (sex-determining region Y)-box 5(Sox5) is up-regulation in breast cancer cellsmore » and depletion of Sox5 inhibits breast cancer cell proliferation, migration, and invasion. Furthermore, depletion of Sox5 in breast cancer cells caused a dramatic decrease in Twist1 and chromosome immunoprecipitation assay showed that Sox5 can bind directly to the Twist1 promoter, suggesting that Sox5 transactivates Twist1 expression. We further demonstrated that knockdown of Sox5 up-regulated epithelial phenotype cell biomarker (E-cadherin) and down-regulated mesenchymal phenotype cell biomarkers (N-cadherin, Vimentin, and Fibronectin 1), resulting in suppression of EMT. Our study suggests that Sox5 transactivates Twist1 expression and plays an important role in the regulation of breast cancer progression.« less

Molecular basis of maple syrup urine disease: Novel mutations at the E1[alpha] locus that impair E1([alpha][sub 2][beta][sub 2]) assembly or decrease steady-state E1[alpha] mRNA levels of branched-chain [alpha]-keto acid dehydrogenase complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chuang, J.L.; Fisher, C.R.; Chuang, D.T.

1994-08-01

The authors report the occurrence of three novel mutations in the E1[alpha] (BCKDHA) locus of the branched-chain [alpha]-keto acid dehydrogenase (BCKAD) complex that cause maple syrup urine disease (MSUD). An 8-bp deletion in exon 7 is present in one allele of a compound-heterozygous patient (GM-649). A single C nucleotide insertion in exon 2 occurs in one allele of an intermediate-MSUD patient (Lo). The second allele of patient Lo carries an A-to-G transition in exon 9 of the E1[alpha] gene. This missense mutation changes Tyr-368 to Cys (Y368C) in the E1[alpha] subunit. Both the 8-bp deletion and the single C insertionmore » generate a downstream nonsense codon. Both mutations appear to be associated with a low abundance of the mutant E1[alpha] mRNA, as determined by allele-specific oligonucleotide probing. Transfection studies strongly suggest that the Y368C substitution in the E1[alpha] subunit impairs its proper assembly with the normal E1[beta]. Unassembled as well as misassembled E1[alpha] and E1[beta] subunits are degraded in the cell. 32 refs., 8 figs.« less

The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells

PubMed Central

Yao, Xin; Pham, Tri; Temple, Brandi; Gray, Selena; Cannon, Cornita; Chen, Renwei; Abdel-Mageed, Asim B.; Biliran, Hector

2016-01-01

The mitochondrial Bcl-2 inhibitor of transcription 1 (Bit1) protein is part of an anoikis-regulating pathway that is selectively dependent on integrins. We previously demonstrated that the caspase-independent apoptotic effector Bit1 exerts tumor suppressive function in lung cancer in part by inhibiting anoikis resistance and anchorage-independent growth in vitro and tumorigenicity in vivo. Herein we show a novel function of Bit1 as an inhibitor cell migration and epithelial–mesenchymal transition (EMT) in the human lung adenocarcinoma A549 cell line. Suppression of endogenous Bit1 expression via siRNA and shRNA strategies promoted mesenchymal phenotypes, including enhanced fibroblastoid morphology and cell migratory potential with concomitant downregulation of the epithelial marker E-cadherin expression. Conversely, ectopic Bit1 expression in A549 cells promoted epithelial transition characterized by cuboidal-like epithelial cell phenotype, reduced cell motility, and upregulated E-cadherin expression. Specific downregulation of E-cadherin in Bit1-transfected cells was sufficient to block Bit1-mediated inhibition of cell motility while forced expression of E-cadherin alone attenuated the enhanced migration of Bit1 knockdown cells, indicating that E-cadherin is a downstream target of Bit1 in regulating cell motility. Furthermore, quantitative real-time PCR and reporter analyses revealed that Bit1 upregulates E-cadherin expression at the transcriptional level through the transcriptional regulator Amino-terminal Enhancer of Split (AES) protein. Importantly, the Bit1/AES pathway induction of E-cadherin expression involves inhibition of the TLE1-mediated repression of E-cadherin, by decreasing TLE1 corepressor occupancy at the E-cadherin promoter as revealed by chromatin immunoprecipitation assays. Consistent with its EMT inhibitory function, exogenous Bit1 expression significantly suppressed the formation of lung metastases of A549 cells in an in vivo experimental

Observation of e + e → Φ χ c 1 and Φ χ c 2 at s = 4.600 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

Using a data sample collected with the BESIII detector operating at the BEPCII storage ring at a centerof- mass energy of √s = 4.600 GeV, we search for the production of e +e - → φχ c0,1,2. A search is also performed for the charmonium-like state X(4140) in the radiative transition e +e - → γX(4140) with X(4140) subsequently decaying into φJ/ψ. The processes e +e - → φχ c1 and φχ c2 are observed for the first time, each with a statistical significance ofmore than 10σ, and the Born cross sections are measuredmore » to be (4.2+1.7 -1.0±0.3) pb and (6.7+3.4 -1.7 ± 0.5) pb, respectively, where the first uncertainties are statistical and the second systematic. No significant signals are observed for e +e - → φχ c0 and e +e - → γX(4140) and upper limits on the Born cross sections at 90% confidence level are provided at √s = 4.600 GeV.« less

Observation of e + e → Φ χ c 1 and Φ χ c 2 at s = 4.600 GeV

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2018-02-12

Using a data sample collected with the BESIII detector operating at the BEPCII storage ring at a centerof- mass energy of √s = 4.600 GeV, we search for the production of e +e - → φχ c0,1,2. A search is also performed for the charmonium-like state X(4140) in the radiative transition e +e - → γX(4140) with X(4140) subsequently decaying into φJ/ψ. The processes e +e - → φχ c1 and φχ c2 are observed for the first time, each with a statistical significance ofmore than 10σ, and the Born cross sections are measuredmore » to be (4.2+1.7 -1.0±0.3) pb and (6.7+3.4 -1.7 ± 0.5) pb, respectively, where the first uncertainties are statistical and the second systematic. No significant signals are observed for e +e - → φχ c0 and e +e - → γX(4140) and upper limits on the Born cross sections at 90% confidence level are provided at √s = 4.600 GeV.« less

Magnetic moments, E3 transitions and the structure of high-spin core excited states in 211Rn

NASA Astrophysics Data System (ADS)

Poletti, A. R.; Dracoulis, G. D.; Byrne, A. P.; Stuchbery, A. E.; Poletti, S. J.; Gerl, J.; Lewis, P. M.

1985-05-01

The results of g-factor measurements of high-spin states in 211Rn are: Ex = 8856 + Δ' keV (Jπ = 63/2-), g = 0.626(7); 6101 + Δ' KeV (49/2+), 0.766(8); 5347 + Δ' KeV (43/2-), 0.74(2); 3927 + Δ KeV (35/2+), 1.017(12); 1578 + Δ KeV (17/2-), 0.912(9). These results together with measured E3 transition strengths and shell model calculations are used to assign configurations to the core excited states in 211Rn. Mixed configurations are required to explain the g-factors and enhanced E3 strengths simultaneously.

78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013), and as extended by the Notice of August 8, 2013.... 5; 22 U.S.C. 7201 et seq.; 22 U.S.C. 7210; E.O. 11912, 41 FR 15825, 3 CFR, 1976 Comp., p. 114; E.O.... 13338, 69 FR 26751, 3 CFR, 2004 Comp., p 168; E.O. 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013...

IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma.

PubMed

Zhao, Chuanzong; Wang, Qian; Wang, Ben; Sun, Qi; He, Zhaobin; Hong, Jianguo; Kuehn, Florian; Liu, Enyu; Zhang, Zongli

2017-12-19

It has been reported that the epithelial-mesenchymal transition (EMT) plays an important role in hepatocellular carcinoma (HCC). However, the relationship between the insulin-like growth factor-1 (IGF-1) and EMT of HCC was not fully elucidated. In the present work, we found that the expression of N-cadherin, Vimentin, Snail1, Snail2, and Twist1 was positively associated with IGF-1R expression, while E-cadherin expression was negatively associated with IGF-1 expression in human HCC samples. Furthermore, we observed that IGF-1 up-regulated the expression of N-cadherin, Vimentin, Snail1, Snail2 and Twist1, and down-regulated the expression of E-cadherin. In addition, Stat5 was induced in IGF-1-treated HepG2 and Hep3B cells, and Stat5 inhibition or siRNA significantly affected IGF-1-induced EMT in HepG2 and Hep3B cells. In conclusion, IGF-1 induces EMT of HCC via Stat5 signaling pathway. Thus, IGF-1/Stat5 can be recommended as a potential and novel therapeutic strategy for HCC patients.

Investigating Extra-solar Planetary System Qatar-1 through Transit Observations

NASA Astrophysics Data System (ADS)

Thakur, Parijat; Mannaday, Vineet Kumar; Jiang, Ing-Guey; Sahu, Devendra Kumar; Chand, Swadesh

2018-04-01

We report the results of the transit timing variation (TTV) analysis of the extra-solar planet Qatar-1b using thirty eight light curves. Our analysis combines thirty five previously available transit light curves with three new transits observed by us between June 2016 and September 2016 using the 2-m Himalayan Chandra Telescope (HCT) at the Indian Astronomical Observatory (Hanle, India). From these transit data, the physical and orbital parameters of the Qatar-1 system are determined. In addition to this, the ephemeris for the orbital period and mid-transit time are refined to investigate the possible TTV. We find that the null-TTV model provides the better fit to the (O-C) data. This indicates that there is no evidence for TTVs to confirm the presence of additional planets in the Qatar-1 system. The use of the 3.6-m Devasthal Optical Telescope (DOT) operated by the Aryabhatta Research Institute of Observational Sciences (ARIES, Nainital, India) could improve the photometric precision to examine the signature of TTVs in this system with a greater accuracy than in the present work.

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer. | Office of Cancer Genomics

Cancer.gov

Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in epithelial-to-mesenchymal transition (EMT). Here, we modeled malignant transformation in human bronchial epithelial cells (HBECs) and determined that EMT and ZEB1 expression are early, critical events in lung cancer pathogenesis. Specific oncogenic mutations in TP53 and KRAS were required for HBECs to engage EMT machinery in response to microenvironmental (serum/TGF-β) or oncogenetic (MYC) factors.

Catching Up on State Transitions in Cygnus X-1

NASA Technical Reports Server (NTRS)

Boeck, Moritz; Hanke, Manfred; Wilms, Joern; Pirner, Stefan; Grinberg, Victoria; Markoff, Sera; Pottschmidt, Katja; Nowak, Michael A.; Pooley, Guy

2008-01-01

In 2005 February we observed Cygnus X-1 over a period of 10 days quasi-continuously with the Rossi X-ray Timing Explorer and the Ryle telescope. We present the results of the spectral and timing analysis on a timescale of 90 min and show that the behavior of Cyg X-1 is similar to that found during our years long monitoring campaign. As a highlight we present evidence for a full transition from the hard to the soft state that happened during less than three hours. The observation provided a more complete picture of a state transition than before, especially concerning the evolution of the time lags, due to unique transition coverage and analysis with high time resolution.

26 CFR 1.860A-1 - Effective dates and transition rules.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and ending before January 1, 1990. (2) Tax avoidance rules—(i) Transfers of certain residual interests... TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860A-1 Effective dates and transition... inclusions accrue in an amount sufficient to satisfy the taxes on the excess inclusions. (iii) Residual...

The GTC exoplanet transit spectroscopy survey . VII. An optical transmission spectrum of WASP-48b

NASA Astrophysics Data System (ADS)

Murgas, F.; Pallé, E.; Parviainen, H.; Chen, G.; Nortmann, L.; Nowak, G.; Cabrera-Lavers, A.; Iro, N.

2017-09-01

Context. Transiting planets offer an excellent opportunity for characterizing the atmospheres of extrasolar planets under very different conditions from those found in our solar system. Aims: We are currently carrying out a ground-based survey to obtain the transmission spectra of several extrasolar planets using the 10 m Gran Telescopio Canarias. In this paper we investigate the extrasolar planet WASP-48b, a hot Jupiter orbiting around an F-type star with a period of 2.14 days. Methods: We obtained long-slit optical spectroscopy of one transit of WASP-48b with the Optical System for Imaging and low-Intermediate-Resolution Integrated Spectroscopy (OSIRIS) spectrograph. We integrated the spectrum of WASP-48 and one reference star in several channels with different wavelength ranges, creating numerous color light curves of the transit. We fit analytic transit curves to the data taking into account the systematic effects present in the time series in an effort to measure the change of the planet-to-star radius ratio (Rp/Rs) across wavelength. The change in transit depth can be compared with atmosphere models to infer the presence of particular atomic or molecular compounds in the atmosphere of WASP-48b. Results: After removing the transit model and systematic trends to the curves we reached precisions between 261 ppm and 455-755 ppm for the white and spectroscopic light curves, respectively. We obtained Rp/Rs uncertainty values between 0.8 × 10-3 and 1.5 × 10-3 for all the curves analyzed in this work. The measured transit depth for the curves made by integrating the wavelength range between 530 nm and 905 nm is in agreement with previous studies. We report a relatively flat transmission spectrum for WASP-48b with no statistical significant detection of atmospheric species, although the theoretical models that fit the data more closely include TiO and VO. The transit light curves are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http

Chameleon halo modeling in f(R) gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li Yin; Department of Physics, University of Chicago, Chicago Illinois 60637; Hu, Wayne

2011-10-15

We model the chameleon effect on cosmological statistics for the modified gravity f(R) model of cosmic acceleration. The chameleon effect, required to make the model compatible with local tests of gravity, reduces force enhancement as a function of the depth of the gravitational potential wells of collapsed structure and so is readily incorporated into a halo model by including parameters for the chameleon mass threshold and rapidity of transition. We show that the abundance of halos around the chameleon mass threshold is enhanced by both the merging from below and the lack of merging to larger masses. This property alsomore » controls the power spectrum in the nonlinear regime and we provide a description of the transition to the linear regime that is valid for a wide range of f(R) models.« less

Structural phase transition, narrow band gap, and room-temperature ferromagnetism in [KNbO{sub 3}]{sub 1−x}[BaNi{sub 1/2}Nb{sub 1/2}O{sub 3−δ}]{sub x} ferroelectrics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Wenliang; Yang, Pingxiong, E-mail: pxyang@ee.ecnu.edu.cn; Chu, Junhao

2014-09-15

Structural phase transition, narrow band gap (E{sub g}), and room-temperature ferromagnetism (RTFM) have been observed in the [KNbO{sub 3}]{sub 1−x}[BaNi{sub 1/2}Nb{sub 1/2}O{sub 3−δ}]{sub x} (KBNNO) ceramics. All the samples have single phase perovskite structure, but exhibit a gradual transition behaviour from the orthorhombic to a cubic structure with the increase of x. Raman spectroscopy analysis not only corroborates this doping-induced change in normal structure but also shows the local crystal symmetry for x ≥ 0.1 compositions to deviate from the idealized cubic perovskite structure. A possible mechanism for the observed specific changes in lattice structure is discussed. Moreover, it ismore » noted that KBNNO with compositions x = 0.1–0.3 have quite narrow E{sub g} of below 1.5 eV, much smaller than the 3.2 eV band gap of parent KNbO{sub 3} (KNO), which is due to the increasing Ni 3d electronic states within the gap of KNO. Furthermore, the KBNNO materials present RTFM near a tetragonal to cubic phase boundary. With increasing x from 0 to 0.3, the magnetism of the samples develops from diamagnetism to ferromagnetism and paramagnetism, originating from the ferromagnetic–antiferromagnetic competition. These results are helpful in the deeper understanding of phase transitions, band gap tunability, and magnetism variations in perovskite oxides and show the potential role, such materials can play, in perovskite solar cells and multiferroic applications.« less

Ro-vibronic transition intensities for triatomic molecules from the exact kinetic energy operator; electronic spectrum for the C̃ 1B2 ← X̃ 1A1 transition in SO2.

PubMed

Zak, Emil J; Tennyson, Jonathan

2017-09-07

A procedure for calculating ro-vibronic transition intensities for triatomic molecules within the Born-Oppenheimer approximation is reported. Ro-vibrational energy levels and wavefunctions are obtained with the DVR3D suite, which solves the nuclear motion problem with an exact kinetic energy operator. Absolute transition intensities are calculated both with the Franck-Condon approximation and with a full transition dipole moment surface. The theoretical scheme is tested on C̃  1 B 2  ← X̃  1 A 1 ro-vibronic transitions of SO 2 . Ab initio potential energy and dipole moment surfaces are generated for this purpose. The calculated ro-vibronic transition intensities and cross sections are compared with the available experimental and theoretical data.

76 FR 39910 - Nine Mile Point Nuclear Station, LLC; Nine Mile Point Nuclear Station, Unit Nos. 1 and 2; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... hearing and intervention via electronic submission through the NRC E-filing system. Requests for a hearing... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... requirements of E-Filing, at least ten (10) days prior to the filing deadline, the [[Page 39912

Quantum phase transitions in spin-1 X X Z chains with rhombic single-ion anisotropy

NASA Astrophysics Data System (ADS)

Ren, Jie; Wang, Yimin; You, Wen-Long

2018-04-01

We explore numerically the inverse participation ratios in the ground state of one-dimensional spin-1 X X Z chains with the rhombic single-ion anisotropy. By employing the techniques of density-matrix renormalization group, effects of the rhombic single-ion anisotropy on various information theoretical measures are investigated, such as the fidelity susceptibility, the quantum coherence, and the entanglement entropy. Their relations with the quantum phase transitions are also analyzed. The phase transitions from the Y -Néel phase to the large-Ex or the Haldane phase can be well characterized by the fidelity susceptibility. The second-order derivative of the ground-state energy indicates all the transitions are of second order. We also find that the quantum coherence, the entanglement entropy, the Schmidt gap, and the inverse participation ratios can be used to detect the critical points of quantum phase transitions. Results drawn from these quantum information observables agree well with each other. Finally we provide a ground-state phase diagram as functions of the exchange anisotropy Δ and the rhombic single-ion anisotropy E .

THE SEARCH FOR A COMPLEX MOLECULE IN A SELECTED HOT CORE REGION: A RIGOROUS ATTEMPT TO CONFIRM TRANS-ETHYL METHYL ETHER TOWARD W51 e1/e2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carroll, P. Brandon; McGuire, Brett A.; Blake, Geoffrey A.

2015-01-20

An extensive search has been conducted to confirm transitions of trans-ethyl methyl ether (tEME, C{sub 2}H{sub 5}OCH{sub 3}), toward the high-mass star forming region W51 e1/e2 using the 12 m Telescope of the Arizona Radio Observatory at wavelengths from 2 mm and 3 mm. In short, we cannot confirm the detection of tEME toward W51 e1/e2 and our results call into question the initial identification of this species by Fuchs et al. Additionally, re-evaluation of the data from the original detection indicates that tEME is not present toward W51 e1/e2 in the abundance reported by Fuchs and colleagues. Typical peak-to-peak noise levels for themore » present observations of W51 e1/e2 were between 10 and 30 mK, yielding an upper limit of the tEME column density of ≤1.5 × 10{sup 15} cm{sup –2}. This would make tEME at least a factor of two times less abundant than dimethyl ether (CH{sub 3}OCH{sub 3}) toward W51 e1/e2. We also performed an extensive search for this species toward the high-mass star forming region Sgr B2(N-LMH) with the National Radio Astronomy Observatory 100 m Green Bank Telescope. No transitions of tEME were detected and we were able to set an upper limit to the tEME column density of ≤4 × 10{sup 14} cm{sup –2} toward this source. Thus, we are able to show that tEME is not a new molecular component of the interstellar medium and that an exacting assessment must be carried out when assigning transitions of new molecular species to astronomical spectra to support the identification of large organic interstellar molecules.« less

Structural, vibrational, and electrical properties of 1 T -TiT e2 under hydrostatic pressure: Experiments and theory

NASA Astrophysics Data System (ADS)

Rajaji, V.; Dutta, Utpal; Sreeparvathy, P. C.; Sarma, Saurav Ch.; Sorb, Y. A.; Joseph, B.; Sahoo, Subodha; Peter, Sebastian C.; Kanchana, V.; Narayana, Chandrabhas

2018-02-01

We report the structural, vibrational, and electrical transport properties up to ˜16 GPa of 1 T -TiT e2 , a prominent layered 2D system. We clearly show signatures of two isostructural transitions at ˜2 GPa and ˜4 GPa obtained from the minima in c /a ratio concomitant with the phonon linewidth anomalies of Eg and A1 g modes around the same pressures, providing a strong indication of unusual electron-phonon coupling associated with these transitions. Resistance measurements present nonlinear behavior over similar pressure ranges shedding light on the electronic origin of these pressure-driven isostructural transitions. These multiple indirect signatures of an electronic transition at ˜2 GPa and ˜4 GPa are discussed in connection with the recent theoretical proposal for 1 T -TiT e2 and also the possibility of an electronic topological transition from our electronic Fermi surface calculations. Between 4 GPa and ˜8 GPa , the c /a ratio shows a plateau suggesting a transformation from an anisotropic 2D layer to a quasi-3D crystal network. First-principles calculations suggest that the 2D to quasi-3D evolution without any structural phase transitions is mainly due to the increased interlayer Te-Te interactions (bridging) via the charge density overlap. In addition, we observed a first-order structural phase transition from the trigonal (P 3 ¯m 1 ) to monoclinic (C 2 /m ) phase at higher pressure regions. We estimate the start of this structural phase transition to be ˜8 GPa and also the coexistence of two phases [trigonal (P 3 ¯m 1 ) and monoclinic (C 2 /m )] was observed from ˜8 GPa to ˜16 GPa .

Observation of e+e-→ϕ χc 1 and ϕ χc 2 at √{s }=4.600 GeV

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Albrecht, M.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bai, Y.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, P. L.; Chen, S. J.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fang, J.; Fang, S. S.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Y. G.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guo, A. Q.; Guo, R. P.; Guo, Y. P.; Haddadi, Z.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, X. Q.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, H. M.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jin, Y.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Khan, T.; Khoukaz, A.; Kiese, P.; Kliemt, R.; Koch, L.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kuemmel, M.; Kuessner, M.; Kuhlmann, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Lavezzi, L.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, K. J.; Li, Kang; Li, Ke; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. M.; Liu, Huanhuan; Liu, Huihui; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, Ke; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqing; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Meng, Z. X.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Mustafa, A.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Pellegrino, J.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Pitka, A.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Richter, M.; Ripka, M.; Rolo, M.; Rong, G.; Rosner, Ch.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, J. J.; Song, W. M.; Song, X. Y.; Sosio, S.; Sowa, C.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, L.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. K.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, G. Y.; Tang, X.; Tapan, I.; Tiemens, M.; Tsednee, B.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, Dan; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, Meng; Wang, P.; Wang, P. L.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Y. J.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiong, X. A.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. H.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Yang; Zhang, Yao; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhou, Y. X.; Zhu, J.; Zhu, J.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2018-02-01

Using a data sample collected with the BESIII detector operating at the BEPCII storage ring at a center-of-mass energy of √{s }=4.600 GeV , we search for the production of e+e-→ϕ χc 0 ,1 ,2 . A search is also performed for the charmonium-like state X (4140 ) in the radiative transition e+e-→γ X (4140 ) with X (4140 ) subsequently decaying into ϕ J /ψ . The processes e+e-→ϕ χc 1 and ϕ χc 2 are observed for the first time, each with a statistical significance of more than 10 σ , and the Born cross sections are measured to be (4. 2-1.0+1.7±0.3 ) and (6. 7-1.7+3.4±0.5 ) pb , respectively, where the first uncertainties are statistical and the second systematic. No significant signals are observed for e+e-→ϕ χc 0 and e+e-→γ X (4140 ) and upper limits on the Born cross sections at 90% C.L. are provided at √{s }=4.600 GeV .

78 FR 50396 - Common Format for Federal Entity Transition Plans

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

..., Associate Administrator, Office of Spectrum Management. [FR Doc. 2013-20149 Filed 8-16-13; 8:45 am] BILLING..., Office of Spectrum Management. Each commenter should include the name of the person or organization... Spectrum Management, National Telecommunications and Information Administration, U.S. Department of...

Hook1 inhibits malignancy and epithelial-mesenchymal transition in hepatocellular carcinoma.

PubMed

Sun, Xu; Zhang, Qi; Chen, Wei; Hu, Qida; Lou, Yu; Fu, Qi-Han; Zhang, Jing-Ying; Chen, Yi-Wen; Ye, Long-Yun; Wang, Yi; Xie, Shang-Zhi; Hu, Li-Qiang; Liang, Ting-Bo; Bai, Xue-Li

2017-07-01

Hook1 is a member of the hook family of coiled-coil proteins, which is recently found to be associated with malignant tumors. However, its biological function in hepatocellular carcinoma is yet unknown. Here, we evaluated the Hook1 levels in human hepatocellular carcinoma samples and matched peritumoral tissues by real-time polymerase chain reaction. Small interfering RNA knockdown and a transforming growth factor-β-induced epithelial-mesenchymal transition model were employed to investigate the biological effects of Hook1 in hepatocellular carcinoma. Our results indicated that Hook1 levels were significantly lower in hepatocellular carcinoma tissues than in the peritumoral tissues. In addition, Hook1 expression was significantly associated with hepatocellular carcinoma malignancy. Hook1 was downregulated after transforming growth factor-β-induced epithelial-mesenchymal transition. Moreover, Hook1 knockdown promoted epithelial-mesenchymal transition and attenuated the sensitivity of hepatocellular carcinoma cells to doxorubicin. In summary, our results indicate that downregulation of Hook1 plays a pivotal role in hepatocellular carcinoma progression via epithelial-mesenchymal transition. Hook1 may be used as a novel marker and therapeutic molecular target in hepatocellular carcinoma.

Dielectric relaxation of 2-ethyl-1-hexanol around the glass transition by thermally stimulated depolarization currents.

PubMed

Arrese-Igor, S; Alegría, A; Colmenero, J

2015-06-07

We explore new routes for characterizing the Debye-like and α relaxation in 2-ethyl-1-hexanol (2E1H) monoalcohol by using low frequency dielectric techniques including thermally stimulated depolarization current (TSDC) techniques and isothermal depolarization current methods. In this way, we have improved the resolution of the overlapped processes making it possible the analysis of the data in terms of a mode composition as expected for a chain-like response. Furthermore the explored ultralow frequencies enabled to study dynamics at relatively low temperatures close to the glass transition (Tg). Results show, on the one hand, that Debye-like and α relaxation timescales dramatically approach to each other upon decreasing temperature to Tg. On the other hand, the analysis of partial polarization TSDC data confirms the single exponential character of the Debye-like relaxation in 2E1H and rules out the presence of Rouse type modes in the scenario of a chain-like response. Finally, on crossing the glass transition, the Debye-like relaxation shows non-equilibrium effects which are further emphasized by aging treatment and would presumably emerge as a result of the arrest of the structural relaxation below Tg.

Ternary alkali-metal and transition metal or metalloid acetylides as alkali-metal intercalation electrodes for batteries

DOEpatents

Nemeth, Karoly; Srajer, George; Harkay, Katherine C; Terdik, Joseph Z

2015-02-10

Novel intercalation electrode materials including ternary acetylides of chemical formula: A.sub.nMC.sub.2 where A is alkali or alkaline-earth element; M is transition metal or metalloid element; C.sub.2 is reference to the acetylide ion; n is an integer that is 0, 1, 2, 3 or 4 when A is alkali element and 0, 1, or 2 when A is alkaline-earth element. The alkali elements are Lithium (Li), Sodium (Na), Potassium (K), Rubidium (Rb), Cesium (Cs) and Francium (Fr). The alkaline-earth elements are Berilium (Be), Magnesium (Mg), Calcium (Ca), Strontium (Sr), Barium (Ba), and Radium (Ra). M is a transition metal that is any element in groups 3 through 12 inclusive on the Periodic Table of Elements (elements 21 (Sc) to element 30 (Zn)). In another exemplary embodiment, M is a metalloid element.

1. GENERAL VIEW SHOWING NORTHEAST END (FRONT) OF TRANSIT SHED, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW SHOWING NORTHEAST END (FRONT) OF TRANSIT SHED, IN CONTEXT WITH LOADING YARD AND DERRICK, LOOKING WEST - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

Temperature dependences of characteristics of 2,5-hexanediol and 1,2,6-hexanetriol cluster structures according to dielectric radiospectroscopy

NASA Astrophysics Data System (ADS)

Usacheva, T. M.; Zhuravlev, V. I.

2013-03-01

Dielectric radiospectra (DRS) of 2,5-hexanediol and 1,2,6-hexanetriol at frequencies of 1 MHz, 9.375, 36.885, and 74.569 GHz in a temperature range of 303-423 K (above the glass transition temperatures) are studied. Experimental DRS are analyzed using the Dissado-Hill (DH) cluster model. The dependence of the equilibrium and relaxation characteristics of DRS on the number of OH groups is studied. The dipole moments of the clusters are calculated. The change in the orientation of the dipole moments of the molecules in the cluster during the rearranging of its structure is characterized through the unit vector of the longitudinal component of dipole moment M e of the cluster. The relation between a change in the Onsager-Kirkwood-Fröhlich correlation factor and the behavior of M e is shown.

75 FR 17947 - Endangered and Threatened Wildlife and Plants; 5-Year Status Reviews of 69 Species in Idaho...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

..., [Unnamed] Drosophila aglaia...... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila differens... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila hemipeza.... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila heteroneura. E U.S.A. (HI) 71 FR 26835; 5/9...

S1(1A1)<--S0(1A1) transition of benzo[g,h,i]perylene in supersonic jets and rare gas matrices.

PubMed

Rouillé, G; Arold, M; Staicu, A; Krasnokutski, S; Huisken, F; Henning, Th; Tan, X; Salama, F

2007-05-07

The study of the S1(1A1)<--S0(1A1) transition of benzo[g,h,i]perylene (BghiP, C22H12) in supersonic jets and solid rare gas matrices is reported. In the jet-cooled spectrum, the origin band position is located at 25,027.1+/-0.2 cm-1, the assignment being supported by the analysis of vibrational shifts and rotational band contours. Except for the origin band, which is weak, all bands are attributed to the fundamental excitation of nontotally symmetric b1 vibrational modes of S1. The intensity pattern is interpreted as a consequence of the weak oscillator strength of the electronic transition combined with intensity-borrowing through vibronic interaction between the S1(1A1) and S2(1B1) states. The spectra of the S1(1A1)<--S0(1A1) and S2(1B1)<--S0(1A1) transitions have also been measured for BghiP in solid neon and argon matrices. The comparison of the redshifts determined for either transition reveals that the polarizability of BghiP is larger in its S2 than in its S1 state. Bandwidths of 2.7 cm-1 measured in supersonic jets, which provide conditions relevant for astrophysics, are similar to those of most diffuse interstellar bands. The electronic transitions of BghiP are found to lie outside the ranges covered by present databases. From the comparison between experimental spectra and theoretical computations, it is concluded that the accuracy of empirical and ab initio approaches in predicting electronic energies is still not sufficient to identify astrophysically interesting candidates for spectroscopic laboratory studies.

78 FR 6839 - Duke Energy Carolinas, LLC, Oconee Nuclear Station, Units 1, 2, and 3 Denial of Amendment to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-31

... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory... procedures described below. To comply with the procedural requirements of E-Filing, at least 10 days prior to...

78 FR 13384 - In the Matter of FirstEnergy Nuclear Operating Co. (Beaver Valley Units 1 and 2); Confirmatory...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... under 10 CFR 2.315(c), must be filed in accordance with NRC E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory documents over the.... To comply with the procedural requirements of E-Filing, at least 10 days prior to the filing deadline...

The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study.

PubMed

Chen, Shi; Zhang, Jia-Qiang; Chen, Jiang-Zhi; Chen, Hui-Xing; Qiu, Fu-Nan; Yan, Mao-Lin; Chen, Yan-Ling; Peng, Cheng-Hong; Tian, Yi-Feng; Wang, Yao-Dong

2017-09-01

This study aims to investigate the roles of lncRNA ANRIL in epithelial-mesenchymal transition (EMT) by regulating the ATM-E2F1 signaling pathway in pancreatic cancer (PC). PC rat models were established and ANRIL overexpression and interference plasmids were transfected. The expression of ANRIL, EMT markers (E-cadherin, N-cadherin and Vimentin) and ATM-E2F1 signaling pathway-related proteins (ATM, E2F1, INK4A, INK4B and ARF) were detected. Small molecule drugs were applied to activate and inhibit the ATM-E2F1 signaling pathway. Transwell assay and the scratch test were adopted to detect cell invasion and migration abilities. ANRIL expression in the PC cells was higher than in normal pancreatic duct epithelial cells. In the PC rat models and PC cells, ANRIL interference promoted the expressions of INK4B, INK4A, ARF and E-cadherin, while reduced N-cadherin and Vimentin expression. Over-expressed ANRIL decreased the expression of INK4B, INK4A, ARF and E-cadherin, but raised N-cadherin and Vimentin expressions. By inhibiting the ATM-E2F1 signaling pathway in PC cells, E-cadherin expression increased but N-cadherin and Vimentin expressions decreased. After ANRIL was silenced or the ATM-E2F1 signaling pathway inhibited, PC cell migration and invasion abilities were decreased. In conclusion, over-expression of lncRNA ANRIL can promote EMT of PC cells by activating the ATM-E2F1 signaling pathway. Copyright © 2017 Elsevier B.V. All rights reserved.

Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.

PubMed

Vujic, Nemanja; Korbelius, Melanie; Leopold, Christina; Duta-Mare, Madalina; Rainer, Silvia; Schlager, Stefanie; Goeritzer, Madeleine; Kolb, Dagmar; Eichmann, Thomas O; Diwoky, Clemens; Zimmer, Andreas; Zimmermann, Robert; Lass, Achim; Radovic, Branislav; Kratky, Dagmar

2017-05-16

Monoglyceride lipase (MGL) hydrolyzes monoglycerides (MGs) to glycerol and fatty acids. Among various MG species MGL also degrades 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid and potent activator of cannabinoid receptors (CBR) 1 and 2. MGL-knockout (-/-) mice exhibit pronounced 2-AG accumulation, but lack central cannabimimetic effects due to CB1R desensitization. We have previously shown that MGL affects plaque stability in apolipoprotein E (ApoE)-/- mice, an established animal model for dyslipidemia and atherosclerosis. In the current study, we investigated functional consequences of MGL deficiency on lipid and energy metabolism in ApoE/MGL double knockout (DKO) mice. MGL deficiency affected hepatic cholesterol metabolism by causing increased cholesterol elimination via the biliary pathway. Moreover, DKO mice exhibit lipid-triggered delay in gastric emptying without major effects on overall triglyceride and cholesterol absorption. The observed phenotype of DKO mice is likely not a consequence of potentiated CB1R signaling but rather dependent on the activation of alternative signaling pathways. We conclude that MGL deficiency causes complex metabolic changes including cholesterol metabolism and regulation of gut transit independent of the endocannabinoid system.

Assessing Uncertainties in Boundary Layer Transition Predictions for HIFiRE-1 at Non-zero Angles of Attack

NASA Technical Reports Server (NTRS)

Marek, Lindsay C.

2011-01-01

Boundary layer stability was analyzed for the HIFiRE-1 flight vehicle geometry for ground tests conducted at the CUBRC LENS I hypersonic shock test facility and the Langley Research Center (LaRC) 20- inch Mach 6 Tunnel. Boundary layer stability results were compared to transition onset location obtained from discrete heat transfer measurements from thin film gauges during the CUBRC test and spatially continuous heat transfer measurements from thermal phosphor paint data during the LaRC test. The focus of this analysis was on conditions at non-zero angles of attack as stability analysis has already been performed at zero degrees angle of attack. Also, the transition onset data obtained during flight testing was at nonzero angles of attack, so this analysis could be expanded in the future to include the results of the flight test data. Stability analysis was performed using the 2D parabolized stability software suite STABL (Stability and Transition Analysis for Hypersonic Boundary Layers) developed at the University of Minnesota and the mean flow solutions were computed using the DPLR finite volume Navier-Stokes computational fluid dynamics (CFD) solver. A center line slice of the 3D mean flow solution was used for the stability analysis to incorporate the angle of attack effects while still taking advantage of the 2D STABL software suite. The N-factors at transition onset and the value of Re(sub theta)/M(sub e), commonly used to predict boundary layer transition onset, were compared for all conditions analyzed. Ground test data was analyzed at Mach 7.2 and Mach 6.0 and angles of attack of 1deg, 3deg and 5deg. At these conditions, the flow was found to be second mode dominant for the HIFiRE-1 slender cone geometry. On the leeward side of the vehicle, a strong trend of transition onset location with angle of attack was observed as the boundary layer on the leeward side of the vehicle developed inflection points at streamwise positions on the vehicle that correlated to

Transition to motherhood in type 1 diabetes: design of the pregnancy and postnatal well-being in transition questionnaires.

PubMed

Rasmussen, Bodil; Dunning, Trisha; Hendrieckx, Christel; Botti, Mari; Speight, Jane

2013-02-27

Life transitions are associated with high levels of stress affecting health behaviours among people with Type 1 diabetes. Transition to motherhood is a major transition with potential complications accelerated by pregnancy with risks of adverse childbirth outcomes and added anxiety and worries about pregnancy outcomes. Further, preparing and going through pregnancy requires vigilant attention to a diabetes management regimen and detailed planning of everyday activities with added stress on women. Psychological and social well-being during and after pregnancy are integral for good pregnancy outcomes for both mother and baby. The aim of this study is to establish the face and content validity of two novel measures assessing the well-being of women with type 1 diabetes in their transition to motherhood, 1) during pregnancy and 2) during the postnatal period. The approach to the development of the Pregnancy and Postnatal Well-being in T1DM Transition questionnaires was based on a four-stage pre-testing process; systematic overview of literature, items development, piloting testing of questionnaire and refinement of questionnaire. The questionnaire was reviewed at every stage by expert clinicians, researchers and representatives from consumer groups. The cognitive debriefing approach confirmed relevance of issues and identified additional items. The literature review and interviews identified three main areas impacting on the women's postnatal self-management; (1) psychological well-being; (2) social environment, (3) physical (maternal and fetal) well-being. The cognitive debriefing in pilot testing of the questionnaire identified that immediate postnatal period was difficult, particularly when the women were breastfeeding and felt depressed. The questionnaires fill an important gap by systematically assessing the psychosocial needs of women with type 1 diabetes during pregnancy and in the immediate postnatal period. The questionnaires can be used in larger data

Effects of steaming treatment on crystallinity and glass transition temperature of Eucalyptuses grandis × E. urophylla

NASA Astrophysics Data System (ADS)

Kong, Lulu; Zhao, Zijian; He, Zhengbin; Yi, Songlin

To investigate the effects of steaming treatment on crystallinity and glass transition temperature, samples of Eucalyptuses grandis × E. urophylla with moisture content of 50%, 70%, and 90% were steamed in saturated steam at 100 °C for 2, 4, 6, and 8 h. The degree of crystallinity (CrI) and glass transition temperature (Tg) were measured via X-ray diffraction and dynamic mechanical analysis, respectively. Results revealed a crystallinity degree of Eucalyptus of 29.9%-34.2%, and a glass transition temperature of 80-94 °C with moisture contents of steamed samples of 20%. Furthermore, steaming was revealed to have an obvious effect on crystallization and glass transition. Values of CrI and Tg showed similar changing characteristics: increasing initially, followed by a decrease with increasing steaming time, reaching a maximum at 2 h. Water within the wood seemed to promote crystallization and glass transition during steaming. All steamed samples tested in this study reached glass transition temperature after 50 min of steaming, and the residual growth stress was released.

PHO-ERK1/2 interaction with mitochondria regulates the permeability transition pore in cardioprotective signaling.

PubMed

Hernández-Reséndiz, Sauri; Zazueta, Cecilia

2014-07-11

The molecular mechanism(s) by which extracellular signal-regulated kinase 1/2 (ERK1/2) and other kinases communicate with downstream targets have not been fully determined. Multiprotein signaling complexes undergoing spatiotemporal redistribution may enhance their interaction with effector proteins promoting cardioprotective response. Particularly, it has been proposed that some active kinases in association with caveolae may converge into mitochondria. Therefore, in this study we investigate if PHO-ERK1/2 interaction with mitochondria may provide a mechanistic link in the regulation of these organelles in cardioprotective signaling. Using a model of dilated cardiomyopathy followed by ischemia-reperfusion injury, we determined ERK1/2 signaling at the level of mitochondria and evaluated its effect on the permeability transition pore. The most important finding of the present study is that, under cardioprotective conditions, a subpopulation of activated ERK1/2 was directed to the mitochondrial membranes through vesicular trafficking, concurring with increased phosphorylation of mitochondrial proteins and inhibition of the mitochondrial permeability transition pore opening. In addition, our results suggest that vesicles enriched with caveolin-3 could form structures that may drive ERK1/2, GSK3β and Akt to mitochondria. Signaling complexes including PHO-ERK, PHO-Akt, PHO-eNOS and caveolin-3 contribute to cardioprotection by directly targeting the mitochondrial proteome and regulating the opening of the permeability transition pore in this model. Copyright © 2013 Elsevier Inc. All rights reserved.

Transiting exoplanets from the CoRoT space mission . VI. CoRoT-Exo-3b: the first secure inhabitant of the brown-dwarf desert

NASA Astrophysics Data System (ADS)

Deleuil, M.; Deeg, H. J.; Alonso, R.; Bouchy, F.; Rouan, D.; Auvergne, M.; Baglin, A.; Aigrain, S.; Almenara, J. M.; Barbieri, M.; Barge, P.; Bruntt, H.; Bordé, P.; Collier Cameron, A.; Csizmadia, Sz.; de La Reza, R.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gandolfi, D.; Gillon, M.; Guenther, E.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Schneider, J.; Shporer, A.; Wuchterl, G.; Zucker, S.

2008-12-01

Context: The CoRoT space mission routinely provides high-precision photometric measurements of thousands of stars that have been continuously observed for months. Aims: The discovery and characterization of the first very massive transiting planetary companion with a short orbital period is reported. Methods: A series of 34 transits was detected in the CoRoT light curve of an F3V star, observed from May to October 2007 for 152 days. The radius was accurately determined and the mass derived for this new transiting, thanks to the combined analysis of the light curve and complementary ground-based observations: high-precision radial-velocity measurements, on-off photometry, and high signal-to-noise spectroscopic observations. Results: CoRoT-Exo-3b has a radius of 1.01 ± 0.07 R_Jup and transits around its F3-type primary every 4.26 days in a synchronous orbit. Its mass of 21.66 ± 1.0 M_Jup, density of 26.4 ± 5.6 g cm-3, and surface gravity of logg = 4.72 clearly distinguish it from the regular close-in planet population, making it the most intriguing transiting substellar object discovered so far. Conclusions: With the current data, the nature of CoRoT-Exo-3b is ambiguous, as it could either be a low-mass brown-dwarf or a member of a new class of “superplanets”. Its discovery may help constrain the evolution of close-in planets and brown-dwarfs better. Finally, CoRoT-Exo-3b confirms the trend that massive transiting giant planets (M ≥ 4 M_Jup) are found preferentially around more massive stars than the Sun. The CoRoT space mission, launched on December 27th 2006, has been developed and is operating by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Table of the COROT photometry is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr

Decreased sleep stage transition pattern complexity in narcolepsy type 1.

PubMed

Ferri, Raffaele; Pizza, Fabio; Vandi, Stefano; Iloti, Martina; Plazzi, Giuseppe

2016-08-01

To analyze the complexity of the nocturnal sleep stage sequence in central disorders of hypersomnolence (CDH), with the hypothesis that narcolepsy type 1 (NT1) might exhibit distinctive sleep stage sequence organization and complexity. Seventy-nine NT1 patients, 22 narcolepsy type 2 (NT2), 22 idiopathic hypersomnia (IH), and 52 patients with subjective hypersomnolence (sHS) were recruited and their nocturnal sleep was polysomnographically recorded and scored. Group between-stage transition probability matrices were obtained and compared. Patients with NT1 differed significantly from all the other patient groups, the latter, in turn, were not different between each other. The individual probability of the R-to-N2 transition was found to be the parameter showing the difference of highest significance between the groups (lowest in NT1) and classified patients with or without NT1 with an accuracy of 78.9% (sensitivity 78.5% and specificity 79.2%), by applying a cut-off value of 0.15. The main result of this study is that the structure of the sleep stage transition pattern of hypocretin-deficient NT1 patients is significantly different from that of other forms of CDH and sHS, with normal hypocretin levels. The lower probability of R-to-N2 transition occurrence in NT1 appears to be a reliable polysomnographic feature with potential application at the individual level, for supportive diagnostic purposes. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

75 FR 2560 - Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... Louisiana State 74 FR 47821; September December 3, 2009 University LSU Museum 17, 2009. of Natural Science... December 22, 2009 Fish and Game. 8, 2009. 227386 David E. Clapham, M.D., 74 FR 58977; November December 22...

Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE

PubMed Central

Ke, Meng; Jiang, Xin; Yan, Nieng

2017-01-01

GLUT1 facilitates the down-gradient translocation of D-glucose across cell membrane in mammals. XylE, an Escherichia coli homolog of GLUT1, utilizes proton gradient as an energy source to drive uphill D-xylose transport. Previous studies of XylE and GLUT1 suggest that the variation between an acidic residue (Asp27 in XylE) and a neutral one (Asn29 in GLUT1) is a key element for their mechanistic divergence. In this work, we combined computational and biochemical approaches to investigate the mechanism of proton coupling by XylE and the functional divergence between GLUT1 and XylE. Using molecular dynamics simulations, we evaluated the free energy profiles of the transition between inward- and outward-facing conformations for the apo proteins. Our results revealed the correlation between the protonation state and conformational preference in XylE, which is supported by the crystal structures. In addition, our simulations suggested a thermodynamic difference between XylE and GLUT1 that cannot be explained by the single residue variation at the protonation site. To understand the molecular basis, we applied Bayesian network models to analyze the alteration in the architecture of the hydrogen bond networks during conformational transition. The models and subsequent experimental validation suggest that multiple residue substitutions are required to produce the thermodynamic and functional distinction between XylE and GLUT1. Despite the lack of simulation studies with substrates, these computational and biochemical characterizations provide unprecedented insight into the mechanistic difference between proton symporters and uniporters. PMID:28617850

Energy spectra of plasma sheet ions and electrons from about 50 eV/e to about 1 MeV during plamsa temperature transitions

NASA Technical Reports Server (NTRS)

Christon, S. P.; Mitchell, D. G.; Williams, D. J.; Frank, L. A.; Huang, C. Y.; Eastman, T. E.

1988-01-01

ISEE-1 charged-particle measurements obtained during eight plasma temperature transitions (PTTs) in 1978-1979 are compiled in tables and graphs and analyzed in detail, comparing the ion and electron differential energy spectra with the predictions of theoretical models. PTTs are defined as approximately 1-h periods of low bulk plasma velocity and steadily increasing or decreasing thermal energy. A Maxwellian distribution is found to be inadequate in describing the PTT energy spectra, but velocity-exponential and kappa distributions are both successful, the latter especially at higher energies. The power-law index kappa varies from PTT to PTT, but the high-energy spectral index and overall shape of the distribution remain constant during a PTT; both spatial and temporal effects are observed.

Structural, vibrational, and electronic topological transitions of Bi1.5Sb0.5Te1.8Se1.2 under pressure

NASA Astrophysics Data System (ADS)

Kim, Joon-Seok; Juneja, Rinkle; Salke, Nilesh P.; Palosz, Witold; Swaminathan, Venkataraman; Trivedi, Sudhir; Singh, Abhishek K.; Akinwande, Deji; Lin, Jung-Fu

2018-03-01

Topological insulators have been the subject of intense research interest due to their unique surface states that are topologically protected against scattering or defects. However, the relationship between the crystal structure and topological insulator state remains to be clarified. Here, we show the effects of hydrostatic pressure on the structural, vibrational, and topological properties of the topological insulator Bi1.5Sb0.5Te1.8Se1.2 up to 45 GPa using X-ray diffraction and Raman spectroscopy in a diamond anvil cell, together with first-principles theoretical calculations. Two pressure-induced structural phase transitions were observed: from ambient rhombohedral R 3 ¯ m phase to a monoclinic C2/m phase at ˜13 GPa, and to a disordered I4/mmm phase at ˜22 GPa. In addition, the alloy undergoes several electronic transitions within the R 3 ¯ m phase: indirect to direct bulk band gap transition at ˜5.8 GPa, bulk gap closing with an appearance of Dirac semimetal (DSM) state at ˜8.2 GPa, and to a trivial semimetal state at ˜12.1 GPa. Anomalies in c/a ratio and Raman full width at half maximum that coincide with the DSM phase suggest the contribution of electron-phonon coupling to the transition. Compared to binary end members Bi2Te3, Bi2Se3, and Sb2Te3, the structural phase transition and anomaly were observed at higher pressures in Bi1.5Sb0.5Te1.8Se1.2. These results suggest that the topological transitions are precursors to the structural phase transitions.

Electric Monopole Transition Strengths in the Stable Nickel Isotopes

NASA Astrophysics Data System (ADS)

Evitts, Lee John

A series of measurements of stable nickel isotopes were performed at the Australian National University in Canberra. Excited states in 58,60,62Ni were populated via inelastic scattering of proton beams delivered by the 14UD Pelletron accelerator. Multiple setups were used in order to determine the structure of low-lying states. The CAESAR array of Compton-suppressed HPGe detectors was used to measure the (E2/M1) mixing ratio of transitions from angular distributions of gamma rays. The Super-e spectrometer was used to measure conversion coefficients for a number of J to J transitions. The data obtained from both devices was combined with previously measured parent lifetimes and branching ratios to determine E0 transition strengths between J-pi transitions. The E0 transition strength for the second 0+ to first 0+ transitions in 60,62Ni have been measured for the first time through internal conversion electron detection. The experimental value of 132(+59,-70) for 62Ni agrees within 2 sigma of the previous result obtained from internal pair formation. However it is likely that the previous experimental results used an outdated theoretical model for internal pair formation emission. This work also represents the first measurements of E0 transition strengths between 2+ states in Ni isotopes. There is generally large E0 strength between the 2+ states, particularly in the second 2+ to first 2+ transition, however there is also a large uncertainty in the measurements owing to the difficulties involved in measuring conversion coefficients. In 62Ni, the E0 transition strength of 172(+62,-77) for the second 2+ to first 2+ transition gives further weight to the argument against the spherical vibrator model, as an E0 transition is forbidden if there is a change of only one phonon. The large measurement also indicates the presence of shape coexistence, complementing the recent experimental work carried out in the neutron-rich Ni isotopes.

FR0CAT: a FIRST catalog of FR 0 radio galaxies

NASA Astrophysics Data System (ADS)

Baldi, R. D.; Capetti, A.; Massaro, F.

2018-01-01

With the aim of exploring the properties of the class of FR 0 radio galaxies, we selected a sample of 108 compact radio sources, called FR0CAT, by combining observations from the NVSS, FIRST, and SDSS surveys. We included in the catalog sources with redshift ≤0.05, with a radio size ≲5 kpc, and with an optical spectrum characteristic of low-excitation galaxies. Their radio luminosities at 1.4 GHz are in the range 1038 ≲ νL1.4 ≲ 1040 erg s-1. The FR0CAT hosts are mostly (86%) luminous (-21 ≳ Mr ≳ -23) red early-type galaxies with black hole masses 108 ≲ MBH ≲ 109M⊙. These properties are similar to those seen for the hosts of FR I radio galaxies, but they are on average a factor 1.6 less massive. The number density of FR0CAT sources is 5 times higher than that of FR Is, and thus they represent the dominant population of radio sources in the local Universe. Different scenarios are considered to account for the smaller sizes and larger abundance of FR 0s with respect to FR Is. An age-size scenario that considers FR 0s as young radio galaxies that will all eventually evolve into extended radio sources cannot be reconciled with the large space density of FR 0s. However, the radio activity recurrence, with the duration of the active phase covering a wide range of values and with short active periods strongly favored with respect to longer ones, might account for their large density number. Alternatively, the jet properties of FR 0s might be intrinsically different from those of the FR Is, the former class having lower bulk Lorentz factors, possibly due to lower black hole spins. Our study indicates that FR 0s and FR I/IIs can be interpreted as two extremes of a continuous population of radio sources that is characterized by a broad distribution of sizes and luminosities of their extended radio emission, but shares a single class of host galaxies.

Planetary transit candidates in Corot-IRa01 field

NASA Astrophysics Data System (ADS)

Carpano, S.; Cabrera, J.; Alonso, R.; Barge, P.; Aigrain, S.; Almenara, J.-M.; Bordé, P.; Bouchy, F.; Carone, L.; Deeg, H. J.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fressin, F.; Fridlund, M.; Gondoin, P.; Guillot, T.; Hatzes, A.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Magain, P.; Moutou, C.; Ofir, A.; Ollivier, M.; Janot-Pacheco, E.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Régulo, C.; Renner, S.; Rouan, D.; Samuel, B.; Schneider, J.; Wuchterl, G.

2009-10-01

Context: CoRoT is a pioneering space mission devoted to the analysis of stellar variability and the photometric detection of extrasolar planets. Aims: We present the list of planetary transit candidates detected in the first field observed by CoRoT, IRa01, the initial run toward the Galactic anticenter, which lasted for 60 days. Methods: We analysed 3898 sources in the coloured bands and 5974 in the monochromatic band. Instrumental noise and stellar variability were taken into account using detrending tools before applying various transit search algorithms. Results: Fifty sources were classified as planetary transit candidates and the most reliable 40 detections were declared targets for follow-up ground-based observations. Two of these targets have so far been confirmed as planets, CoRoT-1b and CoRoT-4b, for which a complete characterization and specific studies were performed. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with contributions from Austria, Belgium, Brazil, ESA, Germany, and Spain. Four French laboratories associated with the CNRS (LESIA, LAM, IAS ,OMP) collaborate with CNES on the satellite development. First CoRoT data are available to the public from the CoRoT archive: http://idoc-corot.ias.u-psud.fr.

Weak e+e- lines from internal pair conversion observed in collisions of 238U with heavy nuclei

NASA Astrophysics Data System (ADS)

Heinz, S.; Berdermann, E.; Heine, F.; Joeres, O.; Kienle, P.; Koenig, I.; Koenig, W.; Kozhuharov, C.; Leinberger, U.; Rhein, M.; Schröter, A.; Tsertos, H.

1998-01-01

We present the results of a Doppler-shift correction to the measured e+e- sum-energy spectra obtained from e+e- coincidence measurements in 238U +206Pb and 238U +181Ta collisions at beam energies close to the Coulomb barrier, using an improved experimental setup at the double-Orange spectrometer of GSI. Internal-Pair-Conversion (IPC) e+e- pairs from discrete nuclear transitions of a moving emitter have been observed following Coulomb excitation of the 1.844 MeV (E1) transition in 206Pb and neutron transfer to the 1.770 MeV (M1) transition in 207Pb. In the collision system 238U +181Ta, IPC transitions were observed from the Ta-like as well as from the U-like nuclei. In all systems the Doppler-shift corrected e+e- sum-energy spectra show weak lines at the energies expected from the corresponding γ ray spectra with cross sections being consistent with the measured excitation cross sections of the γ lines and the theoretically predicted IPC coefficients. No other than IPC e+e- sum-energy lines were found in the measured spectra. The transfer cross sections show a strong dependence on the distance of closest approach (Rmin), thus signaling also a strong dependence on the bombarding energy close to the Coulomb barrier.

M1 transitions in the (sdg) boson model

NASA Astrophysics Data System (ADS)

Kuyucak, S.; Morrison, I.

1988-03-01

Using the {1}/{N} expansion technique we derive expressions for β→g, γ→g and γ→γ M1 transitions in a general boson model. The M1 matrix elements in the sdg-boson model are similar in form to those in the neutron-proton IBM. Comparisons are made to some selected M1 data exhibiting collective character.

Evolution of two-dimensional plasma parameters in the plane of the wafer during the E- to H- and H- to E-mode transition in an inductively coupled plasma

NASA Astrophysics Data System (ADS)

Park, Il-Seo; Kim, Kyung-Hyun; Kim, Tae-Woo; Kim, Kwan-Youg; Moon, Ho-Jun; Chung, Chin-Wook

2018-05-01

The evolution of plasma parameters during the transition from E- to H- and from H- to E-mode is measured at the wafer level two-dimensionally at low and high pressures. The plasma parameters, such as electron density and electron temperature, are obtained through a floating harmonic sideband method. During the E- to H-mode transition, while the electron kinetics remains in the non-local regime at low pressure, the electron kinetics is changed from the non-local to the local regime at high pressure. The two-dimensional profiles of the electron density at two different pressures have similar convex shape despite different electron kinetics. However, in the case of the electron temperature, at high pressure, the profiles of the electron temperature are changed from flat to convex shape. These results can be understood by the diffusion of the plasma to the wafer-level probe. Moreover, between the transition of E to H and reverse H to E, hysteresis is observed even at the wafer level. The hysteresis is clearly shown at high pressure compared to low pressure. This can be explained by a variation of collisional energy loss including effects of electron energy distribution function (bi-Maxwellian, Maxwellian, Druyvesteyn distribution) on the rate constant and multistep ionization of excited state atoms. During the E- to H-mode transition, Maxwellization is caused by increased electron‑electron collisions, which reduces the collisional energy loss at high pressure (Druyvesteyn distribution) and increases it at low pressure (bi-Maxwellian distribution). Thus, the hysteresis is intensified at high pressure because the reduced collisional energy loss leads to higher ionization efficiency.

Pumping of Class 2 methanol masers. 1: The 20 - 3-1E transition

NASA Astrophysics Data System (ADS)

Sobolev, A. M.; Deguchi, S.

1994-11-01

We present a large velocity gradient (LVG) model calculations which explain observed 20 - 3-1E line brightnesses in the strongest Class II methanol masers (MMII). The model explains the variations in spectral appearance of the different maser lines observed from the same source using single-dish facilities through differences in the sensitivities of the line intensities to the MMII physical parameters. In our model masers are pumped by emission of a nearby layer of hot dust with temperature greater than 150 K. The MMII are seen in projection on the H II region producing free-free radio continuum emission. It is shown that radiative excitations from rotational levels of the ground state to the levels of the 2nd and the 1st torsionally excited states both play important role in the pump. We found that the strong MMII (Tb greater than 1010K) should be beamed. The value of (CH3OH)/H2 in the strong MMII sources should exceed 7 x 10-7. Results suggest that the chemistry of the strong MMII was influenced by the shock wave passage. The strong MMII sources should have hydrogen number densities greater than 3 x 106/cu cm and gas temperatures less than 50 K. Thus, results of the present calculations indicate that MMII clumps were exposed to some fast and efficient cooling process. We suppose that local temperature variations can explain the observed absence of spatial coincidence between the MMII and OH maser spots. The MMII with Tb greater than or equal to 109 K can be produced in the sources with the optical depth equal in all directions. Like the strong MMII they should be dense nH greater than (106/cu cm - 3), methanol-abundant ((CH3OH)/H2) greater than 10-7 and relatively cold (T less than 75 K).

Morphological instability of GaAs (7 1 1)A: A transition between (1 0 0) and (5 1 1) terraces

NASA Astrophysics Data System (ADS)

Yazdanpanah, V. R.; Wang, Zh. M.; Salamo, G. J.

2005-06-01

We report on the use of reflection high-energy electron diffraction (RHEED) and scanning tunneling microscopy (STM) study that indicates that the GaAs (7 1 1)A is right at the transition between vicinal GaAs (1 0 0) and vicinal GaAs (5 1 1)A surfaces and that a variation of the As overpressure switches the surface morphology between the two vicinal surfaces. The steps on the vicinal (1 0 0) surface have a width of 1.5 nm creating a staircase surface with excellent possibilities for growth of quantum wells. As-rich conditions can be described by vicinal (5 1 1)A surfaces with a width of 3.5 nm. This surface could find applications as a template for quantum wire growth. The observation suggests that the transition between these two morphologies is understandable based on the increase in surface energy of a vicinal (1 0 0) surface as the step separation approaches the dimer reconstructed separation.

48 CFR 26.203 - Transition of work.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Transition of work. 26.203... PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Disaster or Emergency Assistance Activities 26.203 Transition of work... emergency response work to local firms (e.g., unnecessarily broad scopes of work or long periods of...

48 CFR 26.203 - Transition of work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Transition of work. 26.203... PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Disaster or Emergency Assistance Activities 26.203 Transition of work... emergency response work to local firms (e.g., unnecessarily broad scopes of work or long periods of...

Defending a moving target: H1N1 preparedness training for the transit industry.

PubMed

Faass, Josephine; Greenberg, Michael; Lowrie, Karen W

2013-01-01

To stem the spread of the novel H1N1 virus, U.S. public health officials put forth a variety of recommendations, ranging from practicing social distancing and frequent hand washing at the individual level, to furloughs and continual cleaning of commonly touched surfaces at the level of the organization. Although these steps are amenable to implementation in an office, school or hospital setting, they are nearly impossible to apply in the public transit environment, where large numbers of people remain in close quarters, with no running water and limited opportunities for disinfection. Recognizing the need to offer adequate protection from infection to employees and customers alike, transit officials expressed the need for H1N1-specific training, tailored to industry needs and limitations, to Rutgers University's Center for Transportation Safety, Security and Risk. The resulting course, which was informed through a combination of literature-based and primary research, combined the most current public health data with best practices gleaned from some of the nation's largest transit agencies, in a just-in-time format.

76 FR 18894 - Oil Pollution Prevention

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 112 Oil Pollution Prevention CFR Correction In Title 40 of the Code of Federal Regulations, Parts 100 to 135, revised as of July 1, 2010, on page 71, in Appendix E to Part 112, the second section 5.1 is removed. [FR Doc. 2011-8328 Filed 4-5-11; 8:45 am...

Photon transitions in Upsilon(2S) and Upsilon(3S) decays.

PubMed

Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dambasuren, E; Dorjkhaidav, O; Li, J; Menaa, N; Mountain, R; Muramatsu, H; Nandakumar, R; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Bornheim, A; Pappas, S P; Weinstein, A J; Rosner, J L; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Crede, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Stroiney, S; Sun, W M; Thayer, J G; Urner, D; Wilksen, T; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Wiss, J; Edwards, K W; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Kubota, Y; Lang, B W; Li, S Z; Poling, R; Scott, A W; Smith, A; Stepaniak, C J; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Mahmood, A H; Arms, K; Gan, K K; Severini, H; Asner, D M; Dytman, S A; Love, W; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Adams, G S; Chasse, M; Cravey, M; Cummings, J P; Danko, I; Napolitano, J; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R

2005-01-28

We have studied the inclusive photon spectra in Upsilon(2S) and Upsilon(3S) decays using a large statistics data sample obtained with the CLEO III detector. We present the most precise measurements of electric dipole (E1) photon transition rates and photon energies for Upsilon(2S) --> gammachi(bJ)(1P) and Upsilon(3S) --> gammachi(bJ)(2P) (J = 0, 1, 2). We measure the rate for a rare E1 transition Upsilon(3S) --> gammachi(b0)(1P) for the first time. We also set upper limits on the rates for the hindered magnetic dipole (M1) transitions to the eta(b)(1S) and eta(b)(2S) states.

Statefinder diagnostic and constraints on the Palatini f(R) gravity theories

NASA Astrophysics Data System (ADS)

Cao, Shu-Lei; Li, Song; Yu, Hao-Ran; Zhang, Tong-Jie

2018-03-01

We focus on a series of f(R) gravity theories in Palatini formalism to investigate the probabilities of producing late-time acceleration for the flat Friedmann-Robertson-Walker (FRW) universe. We apply a statefinder diagnostic to these cosmological models for chosen series of parameters to see if they can be distinguished from one another. The diagnostic involves the statefinder pair {r, s}, where r is derived from the scale factor a and its higher derivatives with respect to the cosmic time t, and s is expressed by r and the deceleration parameter q. In conclusion, we find that although two types of f(R) theories: (i) f(R) = R + αRm – βR ‑n and (ii) f(R) = R + α ln R – β can lead to late-time acceleration, their evolutionary trajectories in the r – s and r – q planes reveal different evolutionary properties, which certainly justify the merits of the statefinder diagnostic. Additionally, we utilize the observational Hubble parameter data (OHD) to constrain these models of f(R) gravity. As a result, except for m = n = 1/2 in case (i), α = 0 in case (i) and case (ii) allow the ΛCDM model to exist in the 1σ confidence region. After applying the statefinder diagnostic to the best-fit models, we find that all the best-fit models are capable of going through the deceleration/acceleration transition stage with a late-time acceleration epoch, and all these models turn to the de Sitter point ({r, s} = {1, 0}) in the future. Also, the evolutionary differences between these models are distinct, especially in the r – s plane, which makes the statefinder diagnostic more reliable in discriminating cosmological models.

Transiting exoplanets from the CoRoT space mission. IV. CoRoT-Exo-4b: a transiting planet in a 9.2 day synchronous orbit

NASA Astrophysics Data System (ADS)

Aigrain, S.; Collier Cameron, A.; Ollivier, M.; Pont, F.; Jorda, L.; Almenara, J. M.; Alonso, R.; Barge, P.; Bordé, P.; Bouchy, F.; Deeg, H.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gondoin, P.; Gillon, M.; Guillot, T.; Hatzes, A.; Lammer, H.; Lanza, A. F.; Léger, A.; Llebaria, A.; Magain, P.; Mazeh, T.; Moutou, C.; Paetzold, M.; Pinte, C.; Queloz, D.; Rauer, H.; Rouan, D.; Schneider, J.; Wuchter, G.; Zucker, S.

2008-09-01

CoRoT, the first space-based transit search, provides ultra-high-precision light curves with continuous time-sampling over periods of up to 5 months. This allows the detection of transiting planets with relatively long periods, and the simultaneous study of the host star's photometric variability. In this Letter, we report the discovery of the transiting giant planet CoRoT-Exo-4b and use the CoRoT light curve to perform a detailed analysis of the transit and determine the stellar rotation period. The CoRoT light curve was pre-processed to remove outliers and correct for orbital residuals and artefacts due to hot pixels on the detector. After removing stellar variability about each transit, the transit light curve was analysed to determine the transit parameters. A discrete autocorrelation function method was used to derive the rotation period of the star from the out-of-transit light curve. We determine the periods of the planetary orbit and star's rotation of 9.20205 ± 0.00037 and 8.87 ± 1.12 days respectively, which is consistent with this being a synchronised system. We also derive the inclination, i = 90.00_-0.085+0.000 in degrees, the ratio of the orbital distance to the stellar radius, a/Rs = 17.36-0.25+0.05, and the planet-to-star radius ratio R_p/R_s=0.1047-0.0022+0.0041. We discuss briefly the coincidence between the orbital period of the planet and the stellar rotation period and its possible implications for the system's migration and star-planet interaction history. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Figures 1, 4 and 5 are only available in electronic form at http://www.aanda.org

De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

PubMed Central

McCauley, Heather A; Chevrier, Véronique; Birnbaum, Daniel; Guasch, Géraldine

2017-01-01

Squamous cell carcinomas occurring at transition zones are highly malignant tumors with poor prognosis. The identity of the cell population and the signaling pathways involved in the progression of transition zone squamous cell carcinoma are poorly understood, hence representing limited options for targeted therapies. Here, we identify a highly tumorigenic cancer stem cell population in a mouse model of transitional epithelial carcinoma and uncover a novel mechanism by which loss of TGFβ receptor II (Tgfbr2) mediates invasion and metastasis through de-repression of ELMO1, a RAC-activating guanine exchange factor, specifically in cancer stem cells of transition zone tumors. We identify ELMO1 as a novel target of TGFβ signaling and show that restoration of Tgfbr2 results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcinoma. DOI: http://dx.doi.org/10.7554/eLife.22914.001 PMID:28219480

Direct visualization of a two-dimensional topological insulator in the single-layer 1 T'-WT e2

NASA Astrophysics Data System (ADS)

Jia, Zhen-Yu; Song, Ye-Heng; Li, Xiang-Bing; Ran, Kejing; Lu, Pengchao; Zheng, Hui-Jun; Zhu, Xin-Yang; Shi, Zhi-Qiang; Sun, Jian; Wen, Jinsheng; Xing, Dingyu; Li, Shao-Chun

2017-07-01

We have grown nearly freestanding single-layer 1 T'-WT e2 on graphitized 6 H -SiC(0001) by using molecular beam epitaxy (MBE), and characterized its electronic structure with scanning tunneling microscopy/spectroscopy (STM/STS). The existence of topological edge states at the periphery of single-layer WT e2 islands was confirmed. Surprisingly, a bulk band gap at the Fermi level and insulating behaviors were also found in single-layer WT e2 at low temperature, which are likely associated with an incommensurate charge order transition. The realization of two-dimensional topological insulators (2D TIs) in single-layer transition-metal dichalcogenide provides a promising platform for further exploration of the 2D TIs' physics and related applications.

Inhibition of E2F1 activity and cell cycle progression by arsenic via retinoblastoma protein.

PubMed

Sheldon, Lynn A

2017-01-01

The regulation of cell cycle progression by steroid hormones and growth factors is important for maintaining normal cellular processes including development and cell proliferation. Deregulated progression through the G1/S and G2/M cell cycle transitions can lead to uncontrolled cell proliferation and cancer. The transcription factor E2F1, a key cell cycle regulator, targets genes encoding proteins that regulate cell cycle progression through the G1/S transition as well as proteins important in DNA repair and apoptosis. E2F1 expression and activity is inhibited by inorganic arsenic (iAs) that has a dual role as a cancer therapeutic and as a toxin that leads to diseases including cancer. An understanding of what underlies this dichotomy will contribute to understanding how to use iAs as a more effective therapeutic and also how to treat cancers that iAs promotes. Here, we show that quiescent breast adenocarcinoma MCF-7 cells treated with 17-β estradiol (E2) progress through the cell cycle, but few cells treated with E2 + iAs progress from G1 into S-phase due to a block in cell cycle progression. Our data support a model in which iAs inhibits the dissociation of E2F1 from the tumor suppressor, retinoblastoma protein (pRB) due to changes in pRB phosphorylation which leads to decreased E2F1 transcriptional activity. These findings present an explanation for how iAs can disrupt cell cycle progression through E2F1-pRB and has implications for how iAs acts as a cancer therapeutic as well as how it may promote tumorigenesis through decreased DNA repair.

Search for a massive short-lived axion in nuclear transitions

NASA Astrophysics Data System (ADS)

Hatzikoutelis, Athanasios

Recent reports of the possible existence of an Axion with mass = 9.5 MeV and lifetime less than 10-14 sec do not contradict any negative results of the 20-year long search. The present work aims at confirming or disproving these reports. An Axion may compete with M1 nuclear transitions and decay into a e+-e- pair, producing events with high angle separation, thus being detectable in the presence of internal pair conversion which favors small separation angles. In the present experiment the M1 transitions from two discrete states in 12C were produced using a (d,n) reaction. A hermetic array of plastic scintillator detectors for e+-e- pairs from nuclear transitions was upgraded to 65 elements covering 50% of 4pi. A target chamber made of carbon fiber/epoxy resin, with wall thickness 0.8 mm, was introduced which absorbs only 172. 2 keV of the kinetic energy of minimum ionizing e+/e-. A neutron detector with total efficiency of 3% was constructed to measure the time of flight of neutrons. The detectors and chamber were installed on the beam line of the Stony Brook heavy ion LINAC. A test run was conducted using the reaction 11B(p,e+e-)12C (Ep = 7.2 MeV) to populate the Giant Dipole Resonance of 12C. The observation of the IPC from the 22.6-MeV E1 transition to the ground state of 12C established the pair-energy line-shape and produced an absolute pairenergy calibration. The angular correlation distribution of the pairs was found to be in agreement with the Born and point nucleus approximation of E1 angular correlations. A data run with the stripping reaction 11B(d,n)12C* (Ed = 7.2 MeV) populated the (Ipi,T) = (1+,1) 15.11-MeV and the (1 +,0) 12.7-MeV states of 12C. Detected pair events without neutron coincidence required showed a clear and strong peak of the 15.11 MeV to ground state transition. Analysis of these data agreed with angular correlations of M1 internal pair conversion. These did not support the earlier work and showed no evidence of an Axion emitted in

Scaling laws for mixing and dissipation in unforced rotating stratified turbulence

NASA Astrophysics Data System (ADS)

Pouquet, A.; Rosenberg, D.; Marino, R.; Herbert, C.

2018-06-01

We present a model for the scaling of mixing in weakly rotating stratified flows characterized by their Rossby, Froude and Reynolds numbers Ro, Fr, Re. It is based on quasi-equipartition between kinetic and potential modes, sub-dominant vertical velocity and lessening of the energy transfer to small scales as measured by the ratio rE of kinetic energy dissipation to its dimensional expression. We determine their domains of validity for a numerical study of the unforced Boussinesq equations mostly on grids of 10243 points, with Ro/Fr> 2.5 and with 1600< Re<1.9x104; the Prandtl number is one, initial conditions are either isotropic and at large scale for the velocity, and zero for the temperature {\\theta}, or in geostrophic balance. Three regimes in Fr are observed: dominant waves, eddy-wave interactions and strong turbulence. A wave-turbulence balance for the transfer time leads to rE growing linearly with Fr in the intermediate regime, with a saturation at ~0.3 or more, depending on initial conditions for larger Froude numbers. The Ellison scale is also found to scale linearly with Fr, and the flux Richardson number Rf transitions for roughly the same parameter values as well. Putting together the 3 relationships of the model allows for the prediction of mixing efficiency scaling as Fr-2~RB-1 in the low and intermediate regimes, whereas for higher Fr, it scales as RB-1/2, as already observed: as turbulence strengthens, rE~1, the velocity is isotropic and smaller buoyancy fluxes altogether correspond to a decoupling of velocity and temperature fluctuations, the latter becoming passive.

Reevaluation of the transition-moment function and Einstein coefficients for the N2(A 3Sigma(u)/+/ - X 1Sigma(g)/+/) transition

NASA Astrophysics Data System (ADS)

Piper, Lawrence G.

1993-09-01

We have measured the relative intensities of the nitrogen Vegard-Kaplan bands N2(A 3sigma(u)/+/ - X 1Sigma(g)/+/) for transitions covering a range in r centroids between 1.22 and 1.48 A. With this data we constructed a relative electronic transition moment function that diverges significantly from previously reported functions. We place our data on an absolute basis by normalizing our relative function by the experimentally determined Einstein coefficient for the v prime = 0 to v double prime = 6 transition. Combining our normalized data from 1.22 to 1.48 A with absolute transition moment data measured by Shemansky between 1.08 and 1.14 A results in a function covering the range between 1.08 and 1.48 A. The radiative lifetimes calculated from this function are longer than those currently accepted by amounts varying between 25 percent for v prime = 0-50 percent for v prime = 4-6.

78 FR 13393 - Mississippi Disaster Number MS-00064

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13492 and 13493] Mississippi Disaster Number MS-00064 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an... Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR Doc...

76 FR 58329 - Connecticut Disaster Number CT-00024

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12797 and 12798] Connecticut Disaster Number CT-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an... Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR Doc. 2011...

19 CFR 123.21 - Merchandise in transit.

Code of Federal Regulations, 2012 CFR

2012-04-01

... TREASURY CBP RELATIONS WITH CANADA AND MEXICO Shipments in Transit Through Canada or Mexico § 123.21... States through Canada or Mexico in accordance with the regulations in this subpart or subparts E for... Mexico if: (1) An in-transit manifest is not furnished for the merchandise upon its return to the United...

19 CFR 123.21 - Merchandise in transit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO Shipments in Transit Through Canada or Mexico § 123.21... States through Canada or Mexico in accordance with the regulations in this subpart or subparts E for... Mexico if: (1) An in-transit manifest is not furnished for the merchandise upon its return to the United...

The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons.

PubMed

Yan, Long; Li, Yue; Shi, Zixiao; Lu, Xiaoyin; Ma, Jiao; Hu, Baoyang; Jiao, Jianwei; Wang, Hongmei

2017-08-04

The zinc finger E-box-binding transcription factor Zeb1 plays a pivotal role in the epithelial-mesenchymal transition. Numerous studies have focused on the molecular mechanisms by which Zeb1 contributes to this process. However, the functions of Zeb1 beyond the epithelial-mesenchymal transition remain largely elusive. Using a transdifferentiation system to convert mouse embryonic fibroblasts (MEFs) into functional neurons via the neuronal transcription factors achaete-scute family bHLH (basic helix-loop-helix) transcription factor1 ( Ascl1 ), POU class 3 homeobox 2 (POU3F2/ Brn2 ), and neurogenin 2 (Neurog2, Ngn2 ) (ABN), we found that Zeb1 was up-regulated during the early stages of transdifferentiation. Knocking down Zeb1 dramatically attenuated the transdifferentiation efficiency, whereas Zeb1 overexpression obviously increased the efficiency of transdifferentiation from MEFs to neurons. Interestingly, Zeb1 improved the transdifferentiation efficiency induced by even a single transcription factor ( e.g. Asc1 or Ngn2 ). Zeb1 also rapidly promoted the maturation of induced neuron cells to functional neurons and improved the formation of neuronal patterns and electrophysiological characteristics. Induced neuron cells could form functional synapse in vivo after transplantation. Genome-wide RNA arrays showed that Zeb1 overexpression up-regulated the expression of neuron-specific genes and down-regulated the expression of epithelial-specific genes during conversion. Taken together, our results reveal a new role for Zeb1 in the transdifferentiation of MEFs into neurons. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Foxn1 Transcription Factor Regulates Wound Healing of Skin through Promoting Epithelial-Mesenchymal Transition

PubMed Central

Gawronska-Kozak, Barbara; Grabowska, Anna; Kur-Piotrowska, Anna; Kopcewicz, Marta

2016-01-01

Transcription factors are key molecules that finely tune gene expression in response to injury. We focused on the role of a transcription factor, Foxn1, whose expression is limited to the skin and thymus epithelium. Our previous studies showed that Foxn1 inactivity in nude mice creates a pro-regenerative environment during skin wound healing. To explore the mechanistic role of Foxn1 in the skin wound healing process, we analyzed post-injured skin tissues from Foxn1::Egfp transgenic and C57BL/6 mice with Western Blotting, qRT-PCR, immunofluorescence and flow cytometric assays. Foxn1 expression in non-injured skin localized to the epidermis and hair follicles. Post-injured skin tissues showed an intense Foxn1-eGFP signal at the wound margin and in leading epithelial tongue, where it co-localized with keratin 16, a marker of activated keratinocytes. This data support the concept that suprabasal keratinocytes, expressing Foxn1, are key cells in the process of re-epithelialization. The occurrence of an epithelial-mesenchymal transition (EMT) was confirmed by high levels of Snail1 and Mmp-9 expression as well as through co-localization of vimentin/E-cadherin-positive cells in dermis tissue at four days post-wounding. Involvement of Foxn1 in the EMT process was verified by co-localization of Foxn1-eGFP cells with Snail1 in histological sections. Flow cytometric analysis showed the increase of double positive E-cadherin/N-cadherin cells within Foxn1-eGFP population of post-wounded skin cells isolates, which corroborated histological and gene expression analyses. Together, our findings indicate that Foxn1 acts as regulator of the skin wound healing process through engagement in re-epithelization and possible involvement in scar formation due to Foxn1 activity during the EMT process. PMID:26938103

Spin-Polarization-Induced Preedge Transitions in the Sulfur K-Edge XAS Spectra of Open-Shell Transition-Metal Sulfates: Spectroscopic Validation of σ-Bond Electron Transfer.

PubMed

Frank, Patrick; Szilagyi, Robert K; Gramlich, Volker; Hsu, Hua-Fen; Hedman, Britt; Hodgson, Keith O

2017-02-06

Sulfur K-edge X-ray absorption spectroscopy (XAS) spectra of the monodentate sulfate complexes [M II (itao)(SO 4 )(H 2 O) 0,1 ] (M = Co, Ni, Cu) and [Cu(Me 6 tren)(SO 4 )] exhibit well-defined preedge transitions at 2479.4, 2479.9, 2478.4, and 2477.7 eV, respectively, despite having no direct metal-sulfur bond, while the XAS preedge of [Zn(itao)(SO 4 )] is featureless. The sulfur K-edge XAS of [Cu(itao)(SO 4 )] but not of [Cu(Me 6 tren)(SO 4 )] uniquely exhibits a weak transition at 2472.1 eV, an extraordinary 8.7 eV below the first inflection of the rising K-edge. Preedge transitions also appear in the sulfur K-edge XAS of crystalline [M II (SO 4 )(H 2 O)] (M = Fe, Co, Ni, and Cu, but not Zn) and in sulfates of higher-valent early transition metals. Ground-state density functional theory (DFT) and time-dependent DFT (TDDFT) calculations show that charge transfer from coordinated sulfate to paramagnetic late transition metals produces spin polarization that differentially mixes the spin-up (α) and spin-down (β) spin orbitals of the sulfate ligand, inducing negative spin density at the sulfate sulfur. Ground-state DFT calculations show that sulfur 3p character then mixes into metal 4s and 4p valence orbitals and various combinations of ligand antibonding orbitals, producing measurable sulfur XAS transitions. TDDFT calculations confirm the presence of XAS preedge features 0.5-2 eV below the rising sulfur K-edge energy. The 2472.1 eV feature arises when orbitals at lower energy than the frontier occupied orbitals with S 3p character mix with the copper(II) electron hole. Transmission of spin polarization and thus of radical character through several bonds between the sulfur and electron hole provides a new mechanism for the counterintuitive appearance of preedge transitions in the XAS spectra of transition-metal oxoanion ligands in the absence of any direct metal-absorber bond. The 2472.1 eV transition is evidence for further radicalization from copper(II), which

Spin-Polarization-Induced Preedge Transitions in the Sulfur K-Edge XAS Spectra of Open-Shell Transition-Metal Sulfates: Spectroscopic Validation of σ-Bond Electron Transfer

DOE PAGES

Frank, Patrick; Szilagyi, Robert K.; Gramlich, Volker; ...

2017-01-09

Sulfur K-edge X-ray absorption spectroscopy (XAS) spectra of the monodentate sulfate complexes [M II(itao)(SO 4)(H 2O) 0,1] (M = Co, Ni, Cu) and [Cu(Me 6tren)(SO 4)] exhibit well-defined preedge transitions at 2479.4, 2479.9, 2478.4, and 2477.7 eV, respectively, despite having no direct metal–sulfur bond, while the XAS preedge of [Zn(itao)(SO 4)] is featureless. The sulfur K-edge XAS of [Cu(itao)(SO 4)] but not of [Cu(Me 6tren)(SO 4)] uniquely exhibits a weak transition at 2472.1 eV, an extraordinary 8.7 eV below the first inflection of the rising K-edge. Preedge transitions also appear in the sulfur K-edge XAS of crystalline [M II(SO 4)(Hmore » 2O)] (M = Fe, Co, Ni, and Cu, but not Zn) and in sulfates of higher-valent early transition metals. Ground-state density functional theory (DFT) and time-dependent DFT (TDDFT) calculations show that charge transfer from coordinated sulfate to paramagnetic late transition metals produces spin polarization that differentially mixes the spin-up (α) and spin-down (β) spin orbitals of the sulfate ligand, inducing negative spin density at the sulfate sulfur. Ground-state DFT calculations show that sulfur 3p character then mixes into metal 4s and 4p valence orbitals and various combinations of ligand antibonding orbitals, producing measurable sulfur XAS transitions. TDDFT calculations confirm the presence of XAS preedge features 0.5–2 eV below the rising sulfur K-edge energy. The 2472.1 eV feature arises when orbitals at lower energy than the frontier occupied orbitals with S 3p character mix with the copper(II) electron hole. Transmission of spin polarization and thus of radical character through several bonds between the sulfur and electron hole provides a new mechanism for the counterintuitive appearance of preedge transitions in the XAS spectra of transition-metal oxoanion ligands in the absence of any direct metal–absorber bond. The 2472.1 eV transition is evidence for further radicalization from copper(II), which

The prognostic role of the epithelial-mesenchymal transition markers E-cadherin and Slug in laryngeal squamous cell carcinoma.

PubMed

Cappellesso, Rocco; Marioni, Gino; Crescenzi, Marika; Giacomelli, Luciano; Guzzardo, Vincenza; Mussato, Alessio; Staffieri, Alberto; Martini, Alessandro; Blandamura, Stella; Fassina, Ambrogio

2015-10-01

Laryngeal squamous cell carcinoma (LSCC) prognosis is definitely related to lymph node metastasis. Epithelial-mesenchymal transition (EMT) allows neoplastic cells to gain the plasticity and motility required for tumour progression and metastasis. The aim of this study was to investigate the role of EMT in the prognosis of LSCC. Immunohistochemical analysis of E-cadherin, N-cadherin, Snail, Slug, ZEB1, and ZEB2 was performed in 37 consecutive LSCC cases. Low E-cadherin levels and high Slug levels correlated with both disease recurrence (P = 0.02 and P =0.01, respectively) and shorter disease-free survival (DFS) (P = 0.04 and P = 0.02, respectively). Relative expression levels of CDH1, SNAI2, miR-1 and the miR-200 family were also evaluated. CDH1, miR-200a and miR-200c down-regulation and SNAI2 overexpression were significantly associated with disease recurrence (P = 0.03, P = 0.02, P = 0.04, and P = 0.04, respectively). EMT increases tumour recurrence risk and shortens DFS in LSCC. E-cadherin and Slug immunohistochemical analysis could be useful for identifying patients requiring more aggressive treatment after surgery. © 2015 John Wiley & Sons Ltd.

Phase transition studies of germanium to 1. 25 Mbar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vohra, Y.K.; Brister, K.E.; Desgreniers, S.

1986-05-05

New phase transitions in Ge were observed by energy-dispersive x-ray diffraction techniques for pressures up to 125 GPa (1.25 Mbar) as follows: the ..beta..-Sn structure to the simple hexagonal (sh) phase at 75 +- 3 GPa and to the double hexagonal close-packed structure (dhcp) at 102 +- 5 GPa. These are the highest pressures for which a crystalline structure change has been directly observed in any material by x-ray diffraction. Total-energy pseudopotential calculations predict 84 +- 10 GPa for the ..beta..-Sn to sh phase transition and 105 +- 21 GPa for sh to hcp (not dhcp) transition. The role ofmore » 3d core electrons in increasing the transformation pressures in Ge, as compared to Si, is emphasized.« less

Internal conversion coefficients of high multipole transitions: Experiment and theories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerl, J.; Vijay Sai, K.; Sainath, M.

A compilation of the available experimental internal conversion coefficients (ICCs), {alpha}{sub T}, {alpha}{sub K}, {alpha}{sub L}, and ratios K/L and K/LM of high multipole (L > 2) transitions for a number of elements in the range 21 {<=} Z {<=} 94 is presented. Our listing of experimental data includes 194 data sets on 110 E3 transitions, 10 data sets on 6 E4 transitions, 11 data sets on 7 E5 transitions, 38 data sets on 21 M3 transitions, and 132 data sets on 68 M4 transitions. Data with less than 10% experimental uncertainty have been selected for comparison with the theoreticalmore » values of Hager and Seltzer [R.S. Hager, E.C. Seltzer, Nucl. Data Tables A 4 (1968) 1], Rosel et al. [F. Roesel, H.M. Fries, K. Alder, H.C. Pauli, At. Data Nucl. Data Tables 21 (1978) 91], and BRICC. The relative percentage deviations (%{delta}) have been calculated for each of the above theories and the averages (%{delta}-bar) are estimated. The Band et al. [I.M. Band, M.B. Trzhaskovskaya, C.W. Nestor Jr., P.O. Tikkanen, S. Raman, At. Data Nucl. Data Tables 81 (2002) 1] tables, using the BRICC interpolation code, are seen to give theoretical ICCs closest to experimental values.« less

The transition state structure for binding between TAZ1 of CBP and the disordered Hif-1α CAD.

PubMed

Lindström, Ida; Andersson, Eva; Dogan, Jakob

2018-05-18

Intrinsically disordered proteins (IDPs) are common in eukaryotes. However, relatively few experimental studies have addressed the nature of the rate-limiting transition state for the coupled binding and folding reactions involving IDPs. By using site-directed mutagenesis in combination with kinetics measurements we have here characterized the transition state for binding between the globular TAZ1 domain of CREB binding protein and the intrinsically disordered C-terminal activation domain of Hif-1α (Hif-1α CAD). A total of 17 Hif-1α CAD point-mutations were generated and a Φ-value binding analysis was carried out. We found that native hydrophobic binding interactions are not formed at the transition state. We also investigated the effect the biologically important Hif-1α CAD Asn-803 hydroxylation has on the binding kinetics, and found that the whole destabilization effect due the hydroxylation is within the dissociation rate constant. Thus, the rate-limiting transition state is "disordered-like", with native hydrophobic binding contacts being formed cooperatively after the rate-limiting barrier, which is clearly shown by linear free energy relationships. The same behavior was observed in a previously characterized TAZ1/IDP interaction, which may suggest common features for the rate-limiting transition state for TAZ1/IDP interactions.

Polymorphisme de l'apolipoprotéine E dans la population du nord du Maroc: fréquence et influence sur les paramètres lipidiques

PubMed Central

Benyahya, Fatiha; Barakat, Amina; Ghailani, Naima; Bennani, Mohcine

2013-01-01

Introduction L'objectif de ce travail est de déterminer les fréquences alléliques et génotypiques des sites polymorphes situés dans le gène de l'apolipoprotéine E (apo E) ainsi que leur impact sur les paramètres cliniques et lipidiques dans un échantillon de la population du nord du Maroc cliniquement diagnostiqué ADH. Méthodes Le génotype de l'apo E a été analysé par séquençage direct chez 46 patients cliniquement diagnostiqués ADH selon les critères standards. Résultats Les fréquences des allèles epsilon 3, epsilon 2 et epsilon 4 ont été respectivement 78.3%, 2.2% et 19.6%. La fréquence de l'allèle epsilon 4 est très élevée chez la population du nord du Maroc en comparaison avec les populations des autres régions marocaines. Elle est similaire à celle rapportée dans les pays de l'Europe du nord. Les taux du cholestérol total, du cholestérol LDL ainsi que la présence des xanthomes et les maladies cardiovasculaires ne différent pas entre les génotypes de l'apoE. En revanche, les résultats ont montré une influence de l'allèle epsilon4 sur le taux des triglycérides chez les sujets obèses. Conclusion Le génotype de l'apoE ne peut expliquer le phénotype clinique et biochimique présenté par des patients du Nord du Maroc cliniquement diagnostiqués ADH. PMID:24396563

78 FR 12306 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... effective 4/1/2017. Filed Date: 2/12/13. Accession Number: 20130212-5025. Comments Due: 5 p.m. e.t. 2/25/13... Secretary [FR Doc. 2013-04076 Filed 2-21-13; 8:45 am] BILLING CODE 6717-01-P .... Description: Duke Energy Carolinas 4-1-2013 Neg Rate to be effective 4/1/2013. Filed Date: 2/12/13. Accession...

Analysis of the Rotation-Torsion Spectrum of CH_2DOH Within the e_0, e_1, and o_1 Torsional Levels

NASA Astrophysics Data System (ADS)

Coudert, L. H.; Pearson, John C.; Yu, Shanshan; Margules, L.; Motiyenko, R. A.; Klee, S.

2013-06-01

Since the first assignments of Quade and coworkers, a more satisfactory understanding of the spectrum of CH_2DOH has now been achieved. Thanks to a multidimensional potential energy surface and to a new theoretical approach accounting for the internal rotation of a partially deuterated methyl group, 76 torsional subbands could be identified in the microwave and FIR domains. 8356 rotation and rotation-torsion transitions were also assigned for the three lowest lying torsional levels, e_0, e_1, and o_1, in the microwave and terahertz domains and were analyzed with empirical models. In this paper, a new approach aimed at accounting for the rotation-torsion energy levels of CH_2DOH will be presented. It is based on the exact expression of the generalized 4× 4 inertia tensor of the molecule and accounts for the C_s symmetry of the partially deuterated methyl group, for the dependence of the rotational constants on the angle of internal rotation, and for the rotation-torsion Coriolis coupling. This approach will be used to analyze high-resolution data involving the three lowest lying torsional levels, up to k=11. In addition to the microwave data reported recently,^d new transitions recorded in the terahertz domain at JPL will be analyzed. The results of the analysis will be presented in the paper and the parameters determined in the analysis will be discussed. Quade and Suenram, J. Chem. Phys. {73} (1980) 1127; and Su and Quade, J. Mol. Spec. {134} (1989) 290. Lauvergnat, Coudert, Klee, and Smirnov, J. Mol. Spec. {256} (2009) 204. El Hilali, Coudert, Konov, and Klee, J. Chem. Phys. {135} (2011) 194309. Pearson, Yu, and Drouin, J. Mol. Spec. {280} (2012) 119. Quade and Lin, J. Chem. Phys. {38} (1963) 540.

MASCARA-2 b. A hot Jupiter transiting the mV = 7.6 A-star HD 185603

NASA Astrophysics Data System (ADS)

Talens, G. J. J.; Justesen, A. B.; Albrecht, S.; McCormac, J.; Van Eylen, V.; Otten, G. P. P. L.; Murgas, F.; Palle, E.; Pollacco, D.; Stuik, R.; Spronck, J. F. P.; Lesage, A.-L.; Grundahl, F.; Fredslund Andersen, M.; Antoci, V.; Snellen, I. A. G.

2018-04-01

In this paper we present MASCARA-2 b, a hot Jupiter transiting the mV = 7.6 A2 star HD 185603. Since early 2015, MASCARA has taken more than 1.6 million flux measurements of the star, corresponding to a total of almost 3000 h of observations, revealing a periodic dimming in the flux with a depth of 1.3%. Photometric follow-up observations were performed with the NITES and IAC80 telescopes and spectroscopic measurements were obtained with the Hertzsprung SONG telescope. We find MASCARA-2 b orbits HD 185603 with a period of 3.4741119-0.000006+0.000005 at a distance of 0.057 ± 0.006 au, has a radius of 1.83 ± 0.07 RJ and place a 99% upper limit on the mass of <17 MJ. HD 185603 is a rapidly rotating early-type star with an effective temperature of 8980-130+90 K and a mass and radius of 1.89-0.05+0.06 M⊙, 1.60 ± 0.06 R⊙, respectively. Contrary to most other hot Jupiters transiting early-type stars, the projected planet orbital axis and stellar spin axis are found to be aligned with λ = 0.6 ± 4°. The brightness of the host star and the high equilibrium temperature, 2260 ± 50 K, of MASCARA-2 b make it a suitable target for atmospheric studies from the ground and space. Of particular interest is the detection of TiO, which has recently been detected in the similarly hot planets WASP-33 b and WASP-19 b. Tables of photometry are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/612/A57

The HARPS-N Rocky Planet Search. I. HD 219134 b: A transiting rocky planet in a multi-planet system at 6.5 pc from the Sun

NASA Astrophysics Data System (ADS)

Motalebi, F.; Udry, S.; Gillon, M.; Lovis, C.; Ségransan, D.; Buchhave, L. A.; Demory, B. O.; Malavolta, L.; Dressing, C. D.; Sasselov, D.; Rice, K.; Charbonneau, D.; Collier Cameron, A.; Latham, D.; Molinari, E.; Pepe, F.; Affer, L.; Bonomo, A. S.; Cosentino, R.; Dumusque, X.; Figueira, P.; Fiorenzano, A. F. M.; Gettel, S.; Harutyunyan, A.; Haywood, R. D.; Johnson, J.; Lopez, E.; Lopez-Morales, M.; Mayor, M.; Micela, G.; Mortier, A.; Nascimbeni, V.; Philips, D.; Piotto, G.; Pollacco, D.; Queloz, D.; Sozzetti, A.; Vanderburg, A.; Watson, C. A.

2015-12-01

We know now from radial velocity surveys and transit space missions that planets only a few times more massive than our Earth are frequent around solar-type stars. Fundamental questions about their formation history, physical properties, internal structure, and atmosphere composition are, however, still to be solved. We present here the detection of a system of four low-mass planets around the bright (V = 5.5) and close-by (6.5 pc) star HD 219134. This is the first result of the Rocky Planet Search programme with HARPS-N on the Telescopio Nazionale Galileo in La Palma. The inner planet orbits the star in 3.0935 ± 0.0003 days, on a quasi-circular orbit with a semi-major axis of 0.0382 ± 0.0003 AU. Spitzer observations allowed us to detect the transit of the planet in front of the star making HD 219134 b the nearest known transiting planet to date. From the amplitude of the radial velocity variation (2.25 ± 0.22 ms-1) and observed depth of the transit (359 ± 38 ppm), the planet mass and radius are estimated to be 4.36 ± 0.44 M⊕ and 1.606 ± 0.086 R⊕, leading to a mean density of 5.76 ± 1.09 g cm-3, suggesting a rocky composition. One additional planet with minimum-mass of 2.78 ± 0.65 M⊕ moves on a close-in, quasi-circular orbit with a period of 6.767 ± 0.004 days. The third planet in the system has a period of 46.66 ± 0.08 days and a minimum-mass of 8.94 ± 1.13 M⊕, at 0.233 ± 0.002 AU from the star. Its eccentricity is 0.46 ± 0.11. The period of this planet is close to the rotational period of the star estimated from variations of activity indicators (42.3 ± 0.1 days). The planetary origin of the signal is, however, thepreferred solution as no indication of variation at the corresponding frequency is observed for activity-sensitive parameters. Finally, a fourth additional longer-period planet of mass of 71 M⊕ orbits the star in 1842 days, on an eccentric orbit (e = 0.34 ± 0.17) at a distance of 2.56 AU. The photometric time series and radial

Kepler Stellar Properties Catalog Update for Q1-Q17 DR25 Transit Search

NASA Technical Reports Server (NTRS)

Mathur, Savita; Huber, Daniel

2016-01-01

Huber et al. (2014) presented revised stellar properties for 196,468 Kepler targets, which were used for the Q1-Q16 TPSDV planet search (Tenenbaum et al. 2014). The catalog was based on atmospheric properties (i.e., temperature (Teff), surface gravity (log(g)), and metallicity ([FeH])) published in the literature using a variety of methods (e.g., asteroseismology, spectroscopy, exoplanet transits, photometry), which were then homogeneously fitted to a grid of Dartmouth (DSEP) isochrones (Dotter et al. 2008). The catalog was updated in early 2015 for the Q1-Q17 Data Release (DR) 24 transit search (Seader et al. 2015) based on the latest classifications of Kepler targets in the literature at that time. The methodology followed Huber et al. (2014). Here we provide updated stellar properties of 197,096 Kepler targets. Like the previous catalog, this update is based on atmospheric properties that were either published in the literature or provided by the Kepler community follow-up program (CFOP). The input values again come from different methods: asteroseismology, spectroscopy, flicker, and photometry. This catalog update was developed to support the SOC 9.3 TPSDV planet search (Twicken et al. 2016), which is expected to be the final search and data release by the Kepler project.In this document, we describe the method and the inputs that were used to build the catalog. The methodology follows Huber et al. (2014) with a few improvements as described in Section 2.

78 FR 45282 - Oklahoma Disaster Number OK-00073

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13647 and 13648] Oklahoma Disaster Number OK-00073 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an Amendment of... Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR Doc...

75 FR 57539 - Illinois Disaster Number IL-00025

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12290 and 12291] Illinois Disaster Number IL-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of... Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR Doc. 2010...

76 FR 27739 - Tennessee Disaster Number TN-00051

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12556 and 12557] Tennessee Disaster Number TN-00051 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of... Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR Doc...

[Promoting effect of cyclin D1 overexpression on proliferation and epithelial mesenchymal transition of cervical squamous cell carcinoma SiHa cells].

PubMed

Wang, P; Liu, S; Cheng, B; Wu, X Z; Ding, S S; Xu, L; Liu, Y; Duan, L; Sun, S Z

2017-03-08

Objective: To study effects of cyclin D1 overexpression on the proliferation and differentiation of cervical squamous cell carcinoma SiHa cells and to investigate related signaling molecules. Methods: Primers were designed to amplify the full length of cyclin D1 gene and cyclin D1 gene was amplified by PCR for constructing pcDNA3.1 plasmid vector. The construct was then transfected into SiHa cells, and the cells with stable overexpression of cyclin D1 were established, cyclin D1 gene and protein expression were detected by RT-PCR and Western blot, respectively. Cell growth curve was documented by MTT assay. CK7, E-cadherin, vimentin, Snail gene and protein expression in transfected cells were detected by RT-PCR and Western blot. RT-PCR was used to detect the mRNA expression of proliferation and differentiation-related genes like CDK4, CDK2, p21, p27, cyclin E, Rb, E2F, E6/E7 and Ki-67. After synchronization of cells, RT-PCR was used to detect of cyclin D1 and p21 mRNA expression at different time points of the cell cycle. Results: The G-3 cells with cyclin D1 overexpression were successfully established. The growth curve and Ki-67 mRNA expression accelerated in G-3 cells.Vimentin and Snail expression significantly increased at both gene and protein levels, while E-cadherin, CK7 gene and protein expression significantly decreased, indicating epithelial mesenchymal transitionoccurred in G-3 cells.Meanwhile, mRNA expression of cyclin D1, CDK4, CDK2, p21, p27, cyclin E, E2F and Rb increased, while E6/E7 and p16 showed no significant change. The expression trends of p21 and cyclin D1 were almost identical with fluctuation at different time points in the cell cycle. Conclusions: Overexpression of cyclin D1 induced by gene transfection promotes proliferation and epithelial mesenchymal transition in SiHa cells.The process is accompanied by up-regulation of CDK4, CDK2, p21, p27 and cyclin E genes.p21 expression increases synchronously with cyclin D1, suggesting a regulatory

Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hong, Wei, E-mail: hongwei@tijmu.edu.cn; College of Basic Medicine, Tianjin Medical University, 300070 Tianjin; Li, Jinru

Highlights: Black-Right-Pointing-Pointer Corepressor Alien interacts with histone methyltransferase ESET in vivo. Black-Right-Pointing-Pointer Alien/ESET complex is recruited to nTRE of T3-responsive gene by liganded TR{beta}1. Black-Right-Pointing-Pointer ESET-mediated H3K9 methylation is required for liganded TR{beta}1-repressed transcription. Black-Right-Pointing-Pointer ESET is involved in T3-repressed G1/S phase transition and proliferation. -- Abstract: The ligand-bound thyroid hormone receptor (TR) is known to repress via a negative TRE (nTRE) the expression of E2F1, a key transcription factor that controls the G1/S phase transition. Alien has been identified as a novel interacting factor of E2F1 and acts as a corepressor of E2F1. The detailed molecular mechanism by whichmore » Alien inhibits E2F1 gene expression remains unclear. Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TR{beta}1 within the E2F1 gene promoter. We show that, overexpression of ESET promotes, whereas knockdown of ESET releases, the inhibition of TR{beta}1-regulated gene transcription upon T3 stimulation; and H3K9 methylation is required for TR{beta}1-repressed transcription. Furthermore, depletion of ESET impairs thyroid hormone-repressed proliferation as well as the G1/S transition of the cell cycle. Taken together, our data indicate that ESET is involved in TR{beta}1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation.« less

49 CFR 1.51 - Delegations to Federal Transit Administrator.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Plan No. 2 of 1968 (5 U.S.C. app. 1). (c) Section 10 of the Urban Mass Transportation Assistance Act of... 49 Transportation 1 2010-10-01 2010-10-01 false Delegations to Federal Transit Administrator. 1.51 Section 1.51 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF...

75 FR 971 - Pacific Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

...) and accountability measures (AM). This meeting of the SAC is open to the public. DATES: The meeting... with new ACL and AM requirements. The NS1 guidelines include recommendations for establishing several.... [FR Doc. E9-31427 Filed 1-6-10; 8:45 am] BILLING CODE 3510-22-S ...

The Transition Program for Refugee Children. O.E.E. Evaluation Report, 1982-1983.

ERIC Educational Resources Information Center

Chasin, Karen; And Others

The Transition Program for Refugee Children (TPRC) is designed to provide target students with the linguistic and cultural skills necessary for a successful transition into the educational and societal mainstream. In 1982-83, the program served 885 students in 18 New York City high schools. TPRC funds--provided under the Refugee Act--supported…

Observation of the Hadronic transitions chi(b1,2)(2P)-->omegaUpsilon(1S).

PubMed

Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Dambasuren, E; Dorjkhaidav, O; Mountain, R; Muramatsu, H; Nandakumar, R; Skwarnicki, T; Stone, S; Wang, J C; Mahmood, A H; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Bornheim, A; Lipeles, E; Pappas, S P; Shapiro, A; Sun, W M; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Boisvert, V; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Galik, R S; Gibbons, L; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Magerkurth, A; Mahlke-Krüger, H; Meyer, T O; Mistry, N B; Patterson, J R; Pedlar, T K; Peterson, D; Pivarski, J; Richichi, S J; Riley, D; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Thayer, J G; Urner, D; Wilksen, T; Warburton, A; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Potlia, V; Stoeck, H; Yelton, J; Eisenstein, B I; Gollin, G D; Karliner, I; Lowrey, N; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Besson, D; Gao, K Y; Gong, D T; Kubota, Y; Li, S Z; Poling, R; Scott, A W; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Arms, K; Eckhart, E; Gan, K K; Gwon, C; Severini, H; Skubic, P; Dytman, S A; Mueller, J A; Nam, S; Savinov, V; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Danko, I

2004-06-04

The CLEO Collaboration has made the first observations of hadronic transitions among bottomonium (bbmacr;) states other than the dipion transitions among Upsilon(nS) states. In our study of Upsilon(3S) decays, we find a significant signal for Upsilon(3S)-->gammaomegaUpsilon(1S) that is consistent with radiative decays Upsilon(3S)-->gammachi(b1,2)(2P), followed by chi(b1,2)(2P)-->omegaUpsilon(1S). The branching ratios we obtain are B[chi(b1)(2P)-->omegaUpsilon(1S)]=(1.63(+0.35+0.16)(-0.31-0.15))% and B[chi(b2)(2P)-->omegaUpsilon(1S)]=(1.10(+0.32+0.11)(-0.28-0.10))%, in which the first error is statistical and the second is systematic.

76 FR 57653 - Bacillus thuringiensis eCry3.1Ab Protein in Corn; Temporary Exemption From the Requirement of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

..., entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23... toxicity.'' EPA performs a number of analyses to determine the risks from aggregate exposure to pesticide... considered its validity, completeness, and reliability and the relationship of this information to human risk...

Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis

PubMed Central

Karki, Suman; Surolia, Ranu; Hock, Thomas David; Guroji, Purusotham; Zolak, Jason S.; Duggal, Ryan; Ye, Tong; Thannickal, Victor J.; Antony, Veena B.

2014-01-01

Pleural mesothelial cells (PMCs), which are derived from the mesoderm, exhibit an extraordinary capacity to undergo phenotypic changes during development and disease. PMC transformation and trafficking has a newly defined role in idiopathic pulmonary fibrosis (IPF); however, the contribution of Wilms' tumor 1 (Wt1)-positive PMCs to the generation of pathognomonic myofibroblasts remains unclear. PMCs were obtained from IPF lung explants and healthy donor lungs that were not used for transplantation. Short hairpin Wt1-knockdown PMCs (sh Wt1) were generated with Wt1 shRNA, and morphologic and functional assays were performed in vitro. Loss of Wt1 abrogated the PMC phenotype and showed evidence of mesothelial-to-mesenchymal transition (MMT), with a reduced expression of E-cadherin and an increase in the profibrotic markers α-smooth muscle actin (α-SMA) and fibronectin, along with increased migration and contractility, compared with that of the control. Migration of PMCs in response to active transforming growth factor (TGF)-β1 was assessed by live-cell imaging with 2-photon microscopy and 3D imaging, of Wt1-EGFP transgenic mice. Lineage-tracing experiments to map the fate of Wt1+ PMCs in mouse lung in response to TGF-β1 were also performed by using a Cre-loxP system. Our results, for the first time, demonstrate that Wt1 is necessary for the morphologic integrity of pleural membrane and that loss of Wt1 contributes to IPF via MMT of PMCs into a myofibroblast phenotype.—Karki, S., Surolia, R., Hock, T. D., Guroji, P., Zolak, J. S., Duggal, R., Ye, T., Thannickal, V., J., Antony, V. B. Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis. PMID:24265486

FASCODE - Fast Atmospheric Signature Code (Spectral Transmittance and Radiance)

DTIC Science & Technology

1978-01-16

cA6 Approvued o ulcrlae distrnibuin nimtd I? OSTIUTIN TAEMNT(. te ~FrAc1aieW iRD ADDRES 10- iiON 1diE$@NT.t haul fl TASK VIS. dn IPLM nTAR viNOT...the Voigt line shape profile model discussed above. In addition, the Voigt model provides a proper treatment of the transition region at those

Analysis of new high-precision transit light curves of WASP-10 b: starspot occultations, small planetary radius, and high metallicity

NASA Astrophysics Data System (ADS)

Maciejewski, G.; Raetz, St.; Nettelmann, N.; Seeliger, M.; Adam, C.; Nowak, G.; Neuhäuser, R.

2011-11-01

Context. The WASP-10 planetary system is intriguing because different values of radius have been reported for its transiting exoplanet. The host star exhibits activity in terms of photometric variability, which is caused by the rotational modulation of the spots. Moreover, a periodic modulation has been discovered in transit timing of WASP-10 b, which could be a sign of an additional body perturbing the orbital motion of the transiting planet. Aims: We attempt to refine the physical parameters of the system, in particular the planetary radius, which is crucial for studying the internal structure of the transiting planet. We also determine new mid-transit times to confirm or refute observed anomalies in transit timing. Methods: We acquired high-precision light curves for four transits of WASP-10 b in 2010. Assuming various limb-darkening laws, we generated best-fit models and redetermined parameters of the system. The prayer-bead method and Monte Carlo simulations were used to derive error estimates. Results: Three transit light curves exhibit signatures of the occultations of dark spots by the planet during its passage across the stellar disk. The influence of stellar activity on transit depth is taken into account while determining system parameters. The radius of WASP-10 b is found to be no greater than 1.03+0.07-0.03 Jupiter radii, a value significantly smaller than most previous studies indicate. We calculate interior structure models of the planet, assuming a two-layer structure with one homogeneous envelope atop a rock core. The high value of the WASP-10 b's mean density allows one to consider the planet's internal structure including 270 to 450 Earth masses of heavy elements. Our new mid-transit times confirm that transit timing cannot be explained by a constant period if all literature data points are considered. They are consistent with the ephemeris assuming a periodic variation of transit timing. We show that possible starspot features affecting the

The CaCl2 transition in Stishovite

NASA Astrophysics Data System (ADS)

Cohen, R. E.

2001-12-01

Rutile-structured SiO2, or stishovite, has been the subject of intense theoretical study for the development and testing of theoretical methods.1 The pressure induced phase transition of stishovite to the CaCl2 structure is one of the few cases of phase transitions predicted from first-principles electronic structure theory before being proven experimentally. Such tests are important, because one does not know to what level to trust theoretical predictions unless there are test predictions that are fulfilled. There were some indications of a phase transition from earlier ionic model calculations,3 but confidence in the predicted pressure was low because the model was not sufficiently accurate for the equation of state. Then, Linearized Augmented Plane Wave (LAPW) calculations, which make no assumptions abouyt ionicity, were performed for SiO2, and clearly showed an elastic instability at about 45 GPa.2 Non-hydrostatic experiments showed evidence for a transition, but at about 100 GPa.4 Raman experiments showed softening of the B1g Raman mode frequency, which, if extrapolated, would vanish at about 100 GPa.5 Theory predicted an transition, where the elastic anomaly c11-c12=0, at which point the Raman mode would begin to increase in frequency. A hydrostatic single crystal Raman experiment was done to higher pressures, and the transition was found at about 45-50 GPa, and the Raman spectra were in good agreement with the theoretical predictions.5 Single crystal hydrostatic x-ray studies have verified the transition, and showed that the transition is weakly first-order, with some hysteresis.7 Progress in theoretical studies of stishovite and the transition will be reviewed. 1 Cohen, R. E. In: Silica: Physical Behavior, Geochemistry, and Materials Applications. P. Heaney, C. T. Prewitt and G. V. Gibbs. Washington, D.C., Mineralogical Society of America. 29: 369-402, 1994. 2 Cohen, R. E., In: High Pressure Research in Mineral Physics: Application to Earth and Planetary

OT1_ipascucc_1: Understanding the Origin of Transition Disks via Disk Mass Measurements

NASA Astrophysics Data System (ADS)

Pascucci, I.

2010-07-01

Transition disks are a distinguished group of few Myr-old systems caught in the phase of dispersing their inner dust disk. Three different processes have been proposed to explain this inside-out clearing: grain growth, photoevaporation driven by the central star, and dynamical clearing by a forming giant planet. Which of these processes lead to a transition disk? Distinguishing between them requires the combined knowledge of stellar accretion rates and disk masses. We propose here to use 43.8 hours of PACS spectroscopy to detect the [OI] 63 micron emission line from a sample of 21 well-known transition disks with measured mass accretion rates. We will use this line, in combination with ancillary CO millimeter lines, to measure their gas disk mass. Because gas dominates the mass of protoplanetary disks our approach and choice of lines will enable us to trace the bulk of the disk mass that resides beyond tens of AU from young stars. Our program will quadruple the number of transition disks currently observed with Herschel in this setting and for which disk masses can be measured. We will then place the transition and the ~100 classical/non-transition disks of similar age (from the Herschel KP "Gas in Protoplanetary Systems") in the mass accretion rate-disk mass diagram with two main goals: 1) reveal which gaps have been created by grain growth, photoevaporation, or giant planet formation and 2) from the statistics, determine the main disk dispersal mechanism leading to a transition disk.

Interferometric measurement of the 1S/sub 1/2/-2S/sub 1/2/ transition frequency in atomic hydrogen

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barr, J.R.M.; Girkin, J.M.; Tolchard, J.M.

The 1S/sub 1/2/-2S/sub 1/2/ transition frequency in atomic hydrogen has been interferometrically measured by comparison with a reference line in /sup 130/Te/sub 2/ by Doppler-free two-photon laser spectroscopy. The measured 1S/sub 1/2/-2S/sub 1/2/ transition frequency of 2 466 061 397(25) MHz is in good agreement with the theoretical predictions of Erickson modified to take account of recent measurements of the Rydberg constant. This measurement can be used to deduce a value for the ground-state Lamb shift and gives the result of 8182(25) MHz which compares with a value of 8173.248(81) MHz predicted by Erickson.

Boundary Layer Transition During the Orion Exploration Flight Test 1 (EFT-1)

NASA Technical Reports Server (NTRS)

Kirk, Lindsay C.

2016-01-01

Boundary layer transition was observed in the thermocouple data on the windside backshell of the Orion reentry capsule. Sensors along the windside centerline, as well as off-centerline, indicated transition late in the flight at approximately Mach 4 conditions. Transition progressed as expected, beginning at the sensors closest to the forward bay cover (FBC) and moving towards the heatshield. Sensors placed in off-centerline locations did not follow streamlines, so the progression of transition observed in these sensors is less intuitive. Future analysis will include comparisons to pre-flight predictions and expected transitional behavior will be investigated. Sensors located within the centerline and off-centerline launch abort system (LAS) attach well cavities on the FBC also showed indications of boundary layer transition. The transition within the centerline cavity was observed in the temperature traces prior to transition onset on the sensors upstream of the cavity. Transition behavior within the off centerline LAS attach well cavity will also be investigated. Heatshield thermocouples were placed within Avcoat plugs to attempt to capture transitional behavior as well as better understand the aerothermal environments. Thermocouples were placed in stacks of two or five vertically within the plugs, but the temperature data obtained at the sensors closest to the surface did not immediately indicate transitional behavior. Efforts to use the in depth thermocouple temperatures to reconstruct the surface heat flux are ongoing and any results showing the onset of boundary layer transition obtained from those reconstructions will also be included in this paper. Transition on additional features of interest, including compression pad ramps, will be included if it becomes available.

Can f(R) gravity contribute to (dark) radiation?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morais, João; Bouhmadi-López, Mariam; Capozziello, Salvatore, E-mail: jviegas001@ikasle.ehu.eus, E-mail: mbl@ubi.pt, E-mail: capozziello@na.infn.it

2015-09-01

We discuss the possibility that suitable modifications of gravity could account for some amount of the radiation we observe today, in addition to the possibility of explaining the present speed up of the universe. We start introducing and reviewing cosmological reconstruction methods for metric f(R) theories of gravity that can be considered as one of the straightforward modifications of Einstein's gravity as soon as f(R)≠ R. We then take into account two possible f(R) models which could give rise to (dark) radiation. Constraints on the models are found by using the Planck Collaboration 2015 data within a cosmographic approach and bymore » obtaining the matter power spectrum of those models. The conclusion is that f(R) gravity can only contribute minimally to the (dark) radiation to avoid departures from the observed matter power spectrum at the smallest scales (of the order of 0.01Mpc{sup −1}), i.e., precisely those scales that exited the horizon at the radiation dominated epoch. This result could strongly contribute to select reliable f(R) models.« less

Transition Analysis for the HIFiRE-1 Flight Experiment

NASA Technical Reports Server (NTRS)

Li, Fei; Choudhari, Meelan M.; Chang, Chau-Lyan; Kimmel, Roger; Adamczak, David; Smith, Mark S.

2011-01-01

The HIFiRE-1 flight experiment provided a valuable database pertaining to boundary layer transition over a 7-degree half-angle, circular cone model from supersonic to hypersonic Mach numbers, and a range of Reynolds numbers and angles of incidence. This paper reports the initial findings from the ongoing computational analysis pertaining to the measured in-flight transition behavior. Transition during the ascent phase at nearly zero degree angle of attack is dominated by second mode instabilities except in the vicinity of the cone meridian where a roughness element was placed midway along the length of the cone. The first mode instabilities were found to be weak at all trajectory points analyzed from the ascent phase. For times less than approximately 18.5 seconds into the flight, the peak amplification ratio for second mode disturbances is sufficiently small because of the lower Mach numbers at earlier times, so that the transition behavior inferred from the measurements is attributed to an unknown physical mechanism, potentially related to step discontinuities in surface height near the locations of a change in the surface material. Based on the time histories of temperature and/or heat flux at transducer locations within the aft portion of the cone, the onset of transition correlated with a linear PSE N-factor of approximately 14.

Y Box-Binding Protein 1 Promotes Epithelial-Mesenchymal Transition, Invasion, and Metastasis of Cervical Cancer via Enhancing the Expressions of Snail.

PubMed

Pang, Tianyun; Li, Min; Zhang, Ye; Yong, Weiwei; Kang, Haixian; Yao, Yunhong; Hu, Xinrong

2017-10-01

Y box-binding protein 1 (YB-1) is a potent oncogenic protein. How it regulates Snail in most tumors including cervical cancer is unknown. This article is to study if YB-1 plays a role in cervical cancer via regulating the expression of Snail. Immunohistochemical staining of YB-1, Snail, and E-cadherin (E-cad) was performed on tissue specimens including 35 cases of chronic cervicitis (as a control), 35 cases of cervical intraepithelial neoplasm (CIN) I, 35 cases of CIN II/III, 28 cases of unmetastatic cervical squamous cell carcinoma, and 19 cases of metastatic cervical squamous cell carcinoma. RNA interference technique was used to knock down YB-1, E6, and Snail genes. Quantitative polymerase chain reaction, western blot, and transwell experiment were used to detect RNA, protein, and cell invasion of cervical cancer cell lines Hela and C33A, respectively. First, YB-1 knockdown significantly reduced messenger RNA (mRNA) and protein levels of Snail, followed by the increased mRNA and protein levels of E-cad and the decreased invasive ability in both Hela (human papillomavirus [HPV] 18+) and C33A (HPV-) cell lines. Second, YB-1 and Snail protein were correlatively expressed in the group order of metastatic cervical squamous cell carcinoma > unmetastatic cervical squamous cell carcinoma > CINs > cervicitis, with the inverse expression mode of E-cad in the group order, P value less than 0.01, between any 2 groups. Finally, HPV18 E6 knockdown reduced the mRNA and protein levels of YB-1 and Snail in Hela cells. The results firstly reported that YB-1 whose mRNA expression is regulated by HPV18 E6 promotes epithelial-mesenchymal transition and progression of cervical cancer via enhancing the expressions of Snail, which indicated that YB-1/Snail/epithelial-mesenchymal transition axis could have a potential use in the diagnosis and therapy of cervical cancer metastasis as a cancer marker and molecular target.

PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer*

PubMed Central

Avasarala, Sreedevi; Van Scoyk, Michelle; Karuppusamy Rathinam, Manoj Kumar; Zerayesus, Sereke; Zhao, Xiangmin; Zhang, Wei; Pergande, Melissa R.; Borgia, Jeffrey A.; DeGregori, James; Port, J. David; Winn, Robert A.; Bikkavilli, Rama Kamesh

2015-01-01

Protein arginine methyl transferase 1 (PRMT1) was shown to be up-regulated in cancers and important for cancer cell proliferation. However, the role of PRMT1 in lung cancer progression and metastasis remains incompletely understood. In the present study, we show that PRMT1 is an important regulator of epithelial-mesenchymal transition (EMT), cancer cell migration, and invasion, which are essential processes during cancer progression, and metastasis. Additionally, we have identified Twist1, a basic helix-loop-helix transcription factor and a well-known E-cadherin repressor, as a novel PRMT1 substrate. Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique “methyl arginine mark” for active E-cadherin repression. Therefore, targeting PRMT1-mediated Twist1 methylation might represent a novel strategy for developing new anti-invasive/anti-metastatic drugs. Moreover, methylated Twist1 (Arg-34), as such, could also emerge as a potential important biomarker for lung cancer. PMID:25847239

76 FR 62148 - Title VI; Proposed Circular, Environmental Justice; Proposed Circular

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

...-0055] Title VI; Proposed Circular, Environmental Justice; Proposed Circular AGENCY: Federal Transit... the September 29, 2011, Federal Register Notices titled ``Title VI; Proposed Circular'' and... September 29, 2011, Federal Register Notices titled ``Title VI; Proposed Circular'' (76 FR 60593) and...

Quantum phase transitions and string orders in the spin-1/2 Heisenberg-Ising alternating chain with Dzyaloshinskii-Moriya interaction.

PubMed

Liu, Guang-Hua; You, Wen-Long; Li, Wei; Su, Gang

2015-04-29

Quantum phase transitions (QPTs) and the ground-state phase diagram of the spin-1/2 Heisenberg-Ising alternating chain (HIAC) with uniform Dzyaloshinskii-Moriya (DM) interaction are investigated by a matrix-product-state (MPS) method. By calculating the odd- and even-string order parameters, we recognize two kinds of Haldane phases, i.e. the odd- and even-Haldane phases. Furthermore, doubly degenerate entanglement spectra on odd and even bonds are observed in odd- and even-Haldane phases, respectively. A rich phase diagram including four different phases, i.e. an antiferromagnetic (AF), AF stripe, odd- and even-Haldane phases, is obtained. These phases are found to be separated by continuous QPTs: the topological QPT between the odd- and even-Haldane phases is verified to be continuous and corresponds to conformal field theory with central charge c = 1; while the rest of the phase transitions in the phase diagram are found to be c = 1/2. We also revisit, with our MPS method, the exactly solvable case of HIAC model with DM interactions only on odd bonds and find that the even-Haldane phase disappears, but the other three phases, i.e. the AF, AF stripe and odd-Haldane phases, still remain in the phase diagram. We exhibit the evolution of the even-Haldane phase by tuning the DM interactions on the even bonds gradually.

Special course for Masters and PhD students: phase transitions, Landau theory, 1D Ising model, the dimension of the space and Cosmology

NASA Astrophysics Data System (ADS)

Udodov, Vladimir; Katanov Khakas State Univ Team

2014-03-01

Symmetry breaking transitions. The phenomenological (L.D.Landau, USSR, 1937) way to describe phase transitions (PT's). Order parameter and loss of the symmetry. The second derivative of the free energy changes jump wise at the transition, i.e. we have a mathematical singularity and second order PT (TC>0). Extremes of free energy. A point of loss of stability of the symmetrical phase. The eigenfrequency of PT and soft mode behavior. The conditions of applicability of the Landau theory (A.Levanyuk, 1959, V.Ginzburg, 1960). 1D Ising model and exact solution by a transfer matrix method. Critical exponents in the L.Landau PT's theory and for 1D Ising model. Scaling hypothesis (1965) for 1D Ising model with zero critical temperature. The order of PT in 1D Ising model in the framework of the R.Baxter approach. The anthropic principle and the dimension of the space. Why do we have a three-dimensional space? Big bang, the cosmic vacuum, inflation and PT's. Higgs boson and symmetry breaking transitions. Author acknowledges the support of Katanov Khakas State University.

Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.

PubMed

Jiang, Yang; Feng, Xin; Zheng, Lei; Li, Sheng-Lin; Ge, Xi-Yuan; Zhang, Jian-Guo

2015-09-22

Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and metastasis of salivary adenoid cystic carcinoma (SACC) which is characterized by wide local infiltration, perineural spread, a propensity to local recurrence and late distant metastasis. Our recent studies have disclosed that TGF-β is a crucial factor for EMT in metastatic SACC. In this study, we further uncovered small redox protein thioredoxin 1 (TXN) as a critical mediator of TGF-β induced EMT. Immunohistochemistry analysis revealed significantly higher expressions of TXN, thioredoxin reductase 1 (TXNRD1) and N-cadherin, and lower expression of E-cadherin in human metastatic SACC compared to non-metastatic SACC tissues. Consistently, cultured SACC cells with stable TXN overexpression had decreased E-cadherin and increased N-cadherin as well as Snail and Slug expressions. The enhanced migration and invasion potential of these cells was abrogated by Akt or TXNRD1 inhibitors. Expression of N-cadherin and Akt p-Akt decreased, whereas E-cadherin expression increased in a BBSKE (TXNRD1 inhibitor)-dose-dependent manner. In a xenograft mouse model, TXN overexpression facilitated the metastatic potential of SACC-83 cells to the lung. Our results indicate that TXN plays a key role in SACC invasion and metastasis through the modulation of TGF-β-Akt/GSK-3β on EMT. TXN could be a potential therapeutic target for SACC.

Dynamical Constraints on Non-Transiting Planets at Trappist-1

NASA Astrophysics Data System (ADS)

Jontof-Hutter, Daniel; Truong, Vinh; Ford, Eric; Robertson, Paul; Terrien, Ryan

2018-04-01

The outermost of the seven known planets of Trappist-1 orbits six times closer to its host star than Mercury orbits the sun. The architecture of this system beyond 0.07 AU remains unknown. While the presence of additional planets will ultimately be determined by observations, in the meantime, some constraints can be derived from dynamical models.We will firstly look at the expected signature of additional planets at Trappist-1 on the transit times of the known planets to determine at what distances putatuve planets can be ruled out.Secondly, the remarkably compact configuration of Trappist-1 ensures that the known planets are secularly coupled, keeping their mutual inclinations very small and making their cotransiting geometry likely if Trappist-1h transits. We determine the range of masses and orbital inclinations of a putatuve outer planet that would make the observed configuration unlikely, and compare these to these constraints to those expected from radial velocity observations.

Vitamin E protects against the mitochondrial damage caused by cyclosporin A in LLC-PK1 cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arriba, G. de; Seccion de Nefrologia del Hospital Universitario de Guadalajara; Departamento de Medicina de la Universidad de Alcala de Henares

Cyclosporin A (CsA) has nephrotoxic effects known to involve reactive oxygen species (ROS), since antioxidants prevent the kidney damage induced by this drug. Given that mitochondria are among the main sources of intracellular ROS, the aims of our study were to examine the mitochondrial effects of CsA in the porcine renal endothelial cell line LLC-PK1 and the influence of the antioxidant Vitamin E (Vit E). Following the treatment of LLC-PK1 cells with CsA, we assessed the mitochondrial synthesis of superoxide anion, permeability transition pore opening, mitochondrial membrane potential, cardiolipin peroxidation, cytochrome c release and cellular apoptosis, using flow cytometry andmore » confocal microscopy procedures. Similar experiments were done after Vit E preincubation of cells. CsA treatment increased superoxide anion in a dose-dependent way. CsA opened the permeability transition pores, caused Bax migration to mitochondria, and decreased mitochondrial membrane potential and cardiolipin content. Also CsA released cytochrome c into cytosol and provoked cellular apoptosis. Vit E pretreatment inhibited the effects that CsA induced on mitochondrial structure and function in LLC-PK1 cells and avoided apoptosis. CsA modifies mitochondrial LLC-PK1 cell physiology with loss of negative electrochemical gradient across the inner mitochondrial membrane and increased lipid peroxidation. These features are related to apoptosis and can explain the cellular damage that CsA induces. As Vit E inhibited these effects, our results suggest that they were mediated by an increase in ROS production by mitochondria.« less

Confirmation of an exoplanet using the transit color signature: Kepler-418b, a blended giant planet in a multiplanet system

NASA Astrophysics Data System (ADS)

Tingley, B.; Parviainen, H.; Gandolfi, D.; Deeg, H. J.; Palle, E.; Montañés Rodriguez, P.; Murgas, F.; Alonso, R.; Bruntt, H.; Fridlund, M.

2014-07-01

Aims: We announce confirmation of Kepler-418b, one of two proposed planets in this system. This is the first confirmation of an exoplanet based primarily on the transit color signature technique. Methods: We used the Kepler public data archive combined with multicolor photometry from the Gran Telescopio de Canarias and radial velocity follow-up using FIES at the Nordic Optical Telescope for confirmation. Results: We report a confident detection of a transit color signature that can only be explained by a compact occulting body, entirely ruling out a contaminating eclipsing binary, a hierarchical triple, or a grazing eclipsing binary. Those findings are corroborated by our radial velocity measurements, which put an upper limit of ~1 MJup on the mass of Kepler-418b. We also report that the host star is significantly blended, confirming the ~10% light contamination suspected from the crowding metric in the Kepler light curve measured by the Kepler team. We report detection of an unresolved light source that contributes an additional ~30% to the target star, which would not have been detected without multicolor photometric analysis. The resulting planet-star radius ratio is 0.110 ± 0.0025, more than 25% more than the 0.087 measured by Kepler leading to a radius of 1.20 ± 0.16 RJup instead of the 0.94 RJup measured by the Kepler team. Conclusions: This is the first confirmation of an exoplanet candidate based primarily on the transit color signature, demonstrating that this technique is viable from ground for giant planets. It is particularly useful for planets with long periods such as Kepler-418b, which tend to have long transit durations. While this technique is limited to candidates with deep transits from the ground, it may be possible to confirm earth-like exoplanet candidates with a few hours of observing time with an instrument like the James Webb Space Telescope. Additionally, multicolor photometric analysis of transits can reveal unknown stellar neighbors

Measurements and calculations of high-angular-momentum satellite transitions in Li 1s photoionization

NASA Astrophysics Data System (ADS)

Cheng, W. T.; Kukk, E.; Cubaynes, D.; Chang, J.-C.; Snell, G.; Bozek, J. D.; Wuilleumier, F. J.; Berrah, N.

2000-12-01

Lithium 1s photoelectron spectra are reported in high electron and photon energy resolution, with resolved LS term structure of the Li+ 1snl satellite transitions up to n=6. Branching ratios and anisotropy parameters of individual lines, determined over the 85-130 eV photon energy range, are compared with R-matrix calculations and with previous works. The high-angular-momentum satellite lines (L>=2) are found to contribute significantly to the 1snl satellite cross sections for n=3 and 4, and to become the dominant terms for n>=5. The high-angular-momentum lines exhibit the same photon-energy-dependence as the P-lines, providing experimental evidence that the continuum-continuum state coupling (equivalent to virtual electron collision processes) is responsible for the L>=1 terms in the satellite spectrum, in contrast to the electron relaxation (shake-up) mechanism responsible for the S-terms. The angular distribution of the lines in the Li+ 1snl, n=2-6 groups, determined at 110 eV photon energy, is in good agreement with calculations, showing more isotropic distributions for high-angular-momentum lines.

Universal phase transition in community detectability under a stochastic block model.

PubMed

Chen, Pin-Yu; Hero, Alfred O

2015-03-01

We prove the existence of an asymptotic phase-transition threshold on community detectability for the spectral modularity method [M. E. J. Newman, Phys. Rev. E 74, 036104 (2006) and Proc. Natl. Acad. Sci. (USA) 103, 8577 (2006)] under a stochastic block model. The phase transition on community detectability occurs as the intercommunity edge connection probability p grows. This phase transition separates a subcritical regime of small p, where modularity-based community detection successfully identifies the communities, from a supercritical regime of large p where successful community detection is impossible. We show that, as the community sizes become large, the asymptotic phase-transition threshold p* is equal to √[p1p2], where pi(i=1,2) is the within-community edge connection probability. Thus the phase-transition threshold is universal in the sense that it does not depend on the ratio of community sizes. The universal phase-transition phenomenon is validated by simulations for moderately sized communities. Using the derived expression for the phase-transition threshold, we propose an empirical method for estimating this threshold from real-world data.

77 FR 2972 - Thunder Bay Power Company, Thunder Bay Power, LLC, et al.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... Hydro, LLC. Dayton Fox River, LaSalle County, IL. P-2347-049 Midwest Hydro, Inc. Midwest Hydro, LLC... FR, Neenah Paper FR, Middle Appleton Dam Lower Fox River, LLC and N.E.W. LLC and N.E.W. Outagamie...

48 CFR 34.005-1 - Competition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... between alternative major system concepts and sources, as long as it is economically beneficial and... officer should time solicitation issuance and contract award to maintain continuity of concept development during the transition from withdrawing concept proposer to new contractor. [48 FR 42351, Sept. 19, 1983...

The metal-insulator transition in Fe(1.01-x)Cu(x)Se.

PubMed

Williams, A J; McQueen, T M; Ksenofontov, V; Felser, C; Cava, R J

2009-07-29

Iron selenide, Fe(1.01)Se, the layered parent compound of the recently discovered superconducting arsenide family, has previously been shown to be non-magnetic and superconducting with a critical temperature of 8 K. Here we show that copper can be substituted at the iron site in Fe(1.01)Se up to a solubility limit of 20-30%, after which a first-order transition to the three-dimensional CuFeSe(2) structure type is observed. As little as 1.5% copper is sufficient to suppress the superconductivity, and 4% drives the system through a metal-insulator transition. A local magnetic moment is introduced, which maximizes near 12% doping, where a spin-glass transition near 15 K is observed.

Enzymatic Transition States, Transition-State Analogs, Dynamics, Thermodynamics, and Lifetimes

PubMed Central

Schramm, Vern L.

2017-01-01

Experimental analysis of enzymatic transition-state structures uses kinetic isotope effects (KIEs) to report on bonding and geometry differences between reactants and the transition state. Computational correlation of experimental values with chemical models permits three-dimensional geometric and electrostatic assignment of transition states formed at enzymatic catalytic sites. The combination of experimental and computational access to transition-state information permits (a) the design of transition-state analogs as powerful enzymatic inhibitors, (b) exploration of protein features linked to transition-state structure, (c) analysis of ensemble atomic motions involved in achieving the transition state, (d) transition-state lifetimes, and (e) separation of ground-state (Michaelis complexes) from transition-state effects. Transition-state analogs with picomolar dissociation constants have been achieved for several enzymatic targets. Transition states of closely related isozymes indicate that the protein’s dynamic architecture is linked to transition-state structure. Fast dynamic motions in catalytic sites are linked to transition-state generation. Enzymatic transition states have lifetimes of femtoseconds, the lifetime of bond vibrations. Binding isotope effects (BIEs) reveal relative reactant and transition-state analog binding distortion for comparison with actual transition states. PMID:21675920

Measurements of multipolarities in 227Ra as tests of evidence for stable octupole deformation

NASA Astrophysics Data System (ADS)

Borge, M. J. G.; Burke, D. G.; Gietz, H.; Hill, P.; Kaffrell, N.; Kurcewicz, W.; Løvhøiden, G.; Mattsson, S.; Naumann, R. A.; Nybø, K.; Nyman, G.; Thorsteinsen, T. F.

1987-03-01

Multipolarities of ~30 transitions in 227Ra have been established by measuring conversion electrons following the β - decay of 227Fr. For this purpose a "mini-orange"-type electron spectrometer has been constructed. The 227Fr isotopes were produced by the ISOLDE on-line separator at the CERN Synchro-cyclotron. Internal conversion coefficients were obtained from singles spectra and also from simultaneous γe - and γγ coincidence measurements. The new results support the placement of levels and transitions in the earlier level scheme but require changes in the previously assigned parities for four of the levels. Also, one E0 transition was identified. The results are consistent with previous interpretations for most of the levels that have been used to argue in favour of a small permanent octupole deformation for 227Ra.

76 FR 71119 - Agency Information Collection Activity Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

...The Federal Transit Administration invites public comment about our intention to request the Office of Management and Budget's (OMB) approval to renew the following information collection: 49 U.S.C. Section 5320--Paul S. Sarbanes Transit in Parks Program. The information collected is to monitor projects and satisfy Congressional requests. The Federal Register notice with a 60-day comment period soliciting comments was published on August 29, 2011 (Citation 76 FR 53714). No comments were received from that notice.

75 FR 38540 - Notice of Filing of Plats of Survey, Alaska

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

...: Stephen B. Hamrick, 907-271-5481, fax 907-271-4549, e-mail [email protected] . SUPPLEMENTARY INFORMATION.... Stephen B. Hamrick, Chief Cadastral Surveyor. [FR Doc. 2010-16220 Filed 7-1-10; 8:45 am] BILLING CODE 4310...

Nonradiative transition dynamics in alexandrite

NASA Technical Reports Server (NTRS)

Gayen, S. K.; Wang, W. B.; Petricevic, V.; Alfano, R. R.

1986-01-01

The first direct picosecond time-resolved measurement of the nonradiative transition dynamics between the excited 4T2 pump band and the metastable 2E storage level of the trivalent chromium ion in alexandrite is reported. The nonradiative relaxation times of 17 ps for intra-4T2 vibrational transitions, and 27 ps for 4T2-2E electronic transition are obtained. The thermal repopulation rate of the 4T2 state from the metastable 2E level is of the order 3.5 x 10 to the 9th per s.

Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent

PubMed Central

Carter, Emma J.; Barnes, David; Hoppe, Hans-Jürgen; Hughes, Jennifer; Cobbold, Stephen; Harper, James; Morreau, Hans; Surakhy, Mirvat; Hassan, A. Bassim

2016-01-01

Two important protein-protein interactions establish E-cadherin (Cdh1) in the adhesion complex; homophilic binding via the extra-cellular (EC1) domain and cytoplasmic tail binding to β-catenin. Here, we evaluate whether E-cadherin binding can inhibit β-catenin when there is loss of Adenomatous polyposis coli (APC) from the β-catenin destruction complex. Combined conditional loss of Cdh1 and Apc were generated in the intestine, intestinal adenoma and adenoma organoids. Combined intestinal disruption (Cdh1fl/flApcfl/flVil-CreERT2) resulted in lethality, breakdown of the intestinal barrier, increased Wnt target gene expression and increased nuclear β-catenin localization, suggesting that E-cadherin inhibits β-catenin. Combination with an intestinal stem cell Cre (Lgr5CreERT2) resulted in ApcΔ/Δ recombination and adenoma, but intact Cdh1fl/fl alleles. Cultured ApcΔ/ΔCdh1fl/fl adenoma cells infected with adenovirus-Cre induced Cdh1fl/fl recombination (Cdh1Δ/Δ), disruption of organoid morphology, nuclear β-catenin localization, and cells with an epithelial-mesenchymal phenotype. Complementation with adenovirus expressing wild-type Cdh1 (Cdh1-WT) rescued adhesion and β-catenin membrane localization, yet an EC1 specific double mutant defective in homophilic adhesion (Cdh1-MutW2A, S78W) did not. These data suggest that E-cadherin inhibits β-catenin in the context of disruption of the APC-destruction complex, and that this function is also EC1 domain dependent. Both binding functions of E-cadherin may be required for its tumour suppressor activity. PMID:27566565

MKS1 regulates ciliary INPP5E levels in Joubert syndrome

PubMed Central

Slaats, Gisela G.; Isabella, Christine R.; Kroes, Hester Y.; Dempsey, Jennifer C.; Gremmels, Hendrik; Monroe, Glen R.; Phelps, Ian G.; Duran, Karen J.; Adkins, Jonathan; Kumar, Sairam A.; Knutzen, Dana M.; Knoers, Nine V.; Mendelsohn, Nancy J.; Neubauer, David; Mastroyianni, Sotiria D.; Vogt, Julie; Worgan, Lisa; Karp, Natalya; Bowdin, Sarah; Glass, Ian A.; Parisi, Melissa A.; Otto, Edgar A.; Johnson, Colin A.; Hildebrandt, Friedhelm; van Haaften, Gijs; Giles, Rachel H.; Doherty, Dan

2016-01-01

Background Joubert syndrome (JS) is a recessive ciliopathy characterized by a distinctive brain malformation “the molar tooth sign”. Mutations in >27 genes cause JS, and mutations in 12 of these genes also cause Meckel syndrome (MKS). The goals of this work are to describe the clinical features of MKS1-related JS and determine whether disease causing MKS1 mutations affect cellular phenotypes such as cilium number, length and protein content as potential mechanisms underlying JS. Methods We measured cilium number, length and protein content (ARL13B and INPP5E) by immunofluorescence in fibroblasts from individuals with MKS1-related JS and in a 3D spheroid rescue assay to test the effects of disease-related MKS1 mutations. Results We report MKS1 mutations (eight of them previously unreported) in nine individuals with JS. A minority of the individuals with MKS1-related JS have MKS features. In contrast to the truncating mutations associated with MKS, all of the individuals with MKS1-related JS carry ≥1 non-truncating mutation. Fibroblasts from individuals with MKS1-related JS make normal or fewer cilia than control fibroblasts, their cilia are more variable in length than controls, and show decreased ciliary ARL13B and INPP5E. Additionally, MKS1 mutant alleles have similar effects in 3D spheroids. Conclusions MKS1 functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content, through an ARL13B-dependent mechanism. Mutations in INPP5E also cause JS, so our findings in patient fibroblasts support the notion that loss of INPP5E function, due to either mutation or mislocalization, is a key mechanism underlying JS, downstream of MKS1 and ARL13B. PMID:26490104

Epithelial-to-mesenchymal transition in penile squamous cell carcinoma.

PubMed

Masferrer, Emili; Ferrándiz-Pulido, Carla; Masferrer-Niubò, Magalí; Rodríguez-Rodríguez, Alfredo; Gil, Inmaculada; Pont, Antoni; Servitje, Octavi; García de Herreros, Antonio; Lloveras, Belen; García-Patos, Vicenç; Pujol, Ramon M; Toll, Agustí; Hernández-Muñoz, Inmaculada

2015-02-01

Epithelial-to-mesenchymal transition is a phenomenon in epithelial tumors that involves loss of intercellular adhesion, mesenchymal phenotype acquisition and enhanced migratory potential. While the epithelial-to-mesenchymal transition process has been extensively linked to metastatic progression of squamous cell carcinoma, studies of the role of epithelial-to-mesenchymal transition in squamous cell carcinoma containing high risk human papillomaviruses are scarce. Moreover, to our knowledge epithelial-to-mesenchymal transition involvement in human penile squamous cell carcinoma, which can arise through transforming HPV infections or independently of HPV, has not been investigated. We evaluated the presence of epithelial-to-mesenchymal transition markers and their relationship to HPV in penile squamous cell carcinoma. We assessed the expression of E-cadherin, vimentin and the epithelial-to-mesenchymal transition related transcription factors Twist, Zeb1 and Snail by immunohistochemical staining in 64 penile squamous cell carcinoma cases. HPV was detected by polymerase chain reaction amplification. Simultaneous loss of membranous E-cadherin expression and vimentin over expression were noted in 43.5% of penile squamous cell carcinoma cases. HPV was significantly associated with loss of membranous E-cadherin but not with epithelial-to-mesenchymal transition. Recurrence and mortality rates were significantly higher in cases showing epithelial-to-mesenchymal transition. Our findings indicate that in penile squamous cell carcinoma epithelial-to-mesenchymal transition is associated with poor prognosis but not with the presence of HPV. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Measurement of the e + e - → ηK + K - Cross Section by Means of the SND Detector

NASA Astrophysics Data System (ADS)

Achasov, M. N.; Barnyakov, A. Yu.; Barnyakov, M. Yu.; Beloborodov, K. I.; Berdyugin, A. V.; Bogdanchikov, A. G.; Botov, A. A.; Buzykaev, A. R.; Vasiljev, A. V.; Golubev, V. B.; Dimova, T. V.; Druzhinin, V. P.; Zemlyansky, I. M.; Kardapoltsev, L. V.; Kovrizhin, D. P.; Korol, A. A.; Koshuba, S. V.; Kravchenko, E. A.; Kupich, A. S.; Lysenko, A. P.; Martin, K. A.; Melnikova, N. A.; Obrazovsky, A. E.; Onuchin, A. P.; Pakhtusova, E. V.; Perevedentsev, E. A.; Pugachev, K. V.; Skrinsky, A. N.; Serednyakov, S. I.; Silagadze, Z. K.; Surin, A. V.; Tikhonov, Yu. A.; Usov, Yu. V.; Kharlamov, A. G.; Shatunov, P. Yu.; Shatunov, Yu. M.; Shtol, D. A.

2018-03-01

The cross section for the process e + e - → ηK + K - wasmeasured at c.m. energies in the range between 1.56 and 2.00 GeV in an experiment with the SND detector at the VEPP-2000 e + e - collider. The invariant-mass distribution of kaon pairs is consistent with the hypothesis that the transition through the ηφ intermediate state makes a dominant contribution to the transition in question.

E1 and M1 strength functions at low energy

NASA Astrophysics Data System (ADS)

Schwengner, Ronald; Massarczyk, Ralph; Bemmerer, Daniel; Beyer, Roland; Junghans, Arnd R.; Kögler, Toni; Rusev, Gencho; Tonchev, Anton P.; Tornow, Werner; Wagner, Andreas

2017-09-01

We report photon-scattering experiments using bremsstrahlung at the γELBE facility of Helmholtz-Zentrum Dresden-Rossendorf and using quasi-monoenergetic, polarized γ beams at the HIγS facility of the Triangle Universities Nuclear Laboratory in Durham. To deduce the photoabsorption cross sections at high excitation energy and high level density, unresolved strength in the quasicontinuum of nuclear states has been taken into account. In the analysis of the spectra measured by using bremsstrahlung at γELBE, we perform simulations of statistical γ-ray cascades using the code γDEX to estimate intensities of inelastic transitions to low-lying excited states. Simulated average branching ratios are compared with model-independent branching ratios obtained from spectra measured by using monoenergetic γ beams at HIγS. E1 strength in the energy region of the pygmy dipole resonance is discussed in nuclei around mass 90 and in xenon isotopes. M1 strength in the region of the spin-flip resonance is also considered for xenon isotopes. The dipole strength function of 74Ge deduced from γELBE experiments is compared with the one obtained from experiments at the Oslo Cyclotron Laboratory. The low-energy upbend seen in the Oslo data is interpreted as M1 strength on the basis of shell-model calculations.

75 FR 82382 - Electronic Tariff Filings; Notice of Technical Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RM01-5-000] Electronic... electronic filing of tariff and tariff related materials pursuant to Order No. 714.\\1\\ The technical... implementation of eTariff. \\1\\ Electronic Tariff Filings, Order No. 714, 73 FR 57,515 (Oct. 3, 2008), 124 FERC...

Unusual structural transition of antimicrobial VP1 peptide.

PubMed

Shanmugam, Ganesh; Phambu, Nsoki; Polavarapu, Prasad L

2011-05-01

VP1 peptide, an active domain of m-calpain enzyme with antimicrobial activity is found to undergo an unusual conformational transition in trifluoroethanol (TFE) solvent. The nature of, and time dependent variations in, circular dichroism associated with the amide I vibrations, suggest that VP1 undergoes self-aggregation forming anti-parallel β-sheet structure in TFE. Transmission electron micrograph (TEM) images revealed that β-sheet aggregates formed by VP1 possess fibril-like assemblies. Copyright © 2011 Elsevier B.V. All rights reserved.

Observation and modelling of main-sequence star chromospheres - XII. Two-component model chromospheres for five active dM1e stars

NASA Astrophysics Data System (ADS)

Houdebine, E. R.

2009-08-01

We aim to constrain the Hα, CaII H and CaII K profiles from quiescent and active regions on active dM1e stars. A preliminary analysis of all the data available for dM1e stars shows that the Hα/CaII equivalent width (EW) ratio varies by up to a factor of 7 for different stars in our sample. We find that spectroscopic binaries have a significantly smaller ratio than single dM1e stars. We also find that the pre-main-sequence stars Gl 616.2, GJ 1264 and Gl 803 have a ratio lower than main-sequence single dM1e stars. These differences imply that different chromospheric structures are present on different stars, notably the temperature minimum must decrease with an increasing Hα/CaII EW ratio. For these reasons, it is impossible to reproduce all observations with only one grid of model chromospheres. We show that the grid of model chromospheres of Paper VI is adequate to describe the physical conditions that prevail in the chromospheres of spectroscopic binaries and pre-main-sequence M1e stars, but not for the conditions in single dM1e stars. One or more additional grids of model chromospheres will be necessary to reproduce all observations. We use the method developed in Paper XI in this series, in order to build two-component model chromospheres for five M1e field stars: FF And A, FF And B, GJ 1264, AU Mic and Gl 815A. Our solutions provide an exact match of the Hα and the mean CaII H & K EWs within measurement uncertainties. We compare the theoretical profiles and the observed profiles of Hα and the CaII H & K resonance lines. On the one hand, our fits to the CaII lines are reasonably good. On the other hand, our models tend to produce Hα profiles with a central absorption that is too deep. This suggests that the column mass at the transition region for plages is underestimated, but this would imply that the contrast factor between quiescent and active regions in the CaII lines is larger than 5. We find that, except in the cases of FF And A and AU Mic, the total

17 CFR 270.12d1-1 - Exemptions for investments in money market funds.

Code of Federal Regulations, 2010 CFR

2010-04-01

...)(3) and 270.17e-1(d)(2), the payment of a commission, fee, or other remuneration to a broker shall be...) of the Act if: (1) The commission, fee, or other remuneration is paid in connection with the sale of... directors, the company's investment adviser performs the duties of the board of directors. [71 FR 36655...

75 FR 35104 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-21

... Announcement: 75 FR 34183, June 16, 2010. STATUS: Open Meeting. PLACE: 100 F Street, NE., Washington, DC. DATE...: Cancellation of Meeting. The Open Meeting scheduled for Friday, June 18, 2010 at 10 a.m. has been cancelled..., 2010. Florence E. Harmon, Deputy Secretary. [FR Doc. 2010-15011 Filed 6-17-10; 11:15 am] BILLING CODE P ...

Nickel-induced Epithelial-Mesenchymal Transition by Reactive Oxygen Species Generation and E-cadherin Promoter Hypermethylation*

PubMed Central

Wu, Chih-Hsien; Tang, Sheau-Chung; Wang, Po-Hui; Lee, Huei; Ko, Jiunn-Liang

2012-01-01

Epithelial-mesenchymal transition (EMT) is considered a critical event in the pathogenesis of lung fibrosis and tumor metastasis. During EMT, the expression of differentiation markers switches from cell-cell junction proteins such as E-cadherin to mesenchymal markers such as fibronectin. Although nickel-containing compounds have been shown to be associated with lung carcinogenesis, the role of nickel in the EMT process in bronchial epithelial cells is not clear. The aim of this study was to examine whether nickel contributes to EMT in human bronchial epithelial cells. We also attempted to clarify the mechanisms involved in NiCl2-induced EMT. Our results showed that NiCl2 induced EMT phenotype marker alterations such as up-regulation of fibronectin and down-regulation of E-cadherin. In addition, the potent antioxidant N-acetylcysteine blocked EMT and expression of HIF-1α induced by NiCl2, whereas the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine restored the down-regulation of E-cadherin induced by NiCl2. Promoter hypermethylation of E-cadherin, determined by quantitative real time methyl-specific PCR and bisulfate sequencing, was also induced by NiCl2. These results shed new light on the contribution of NiCl2 to carcinogenesis. Specifically, NiCl2 induces down-regulation of E-cadherin by reactive oxygen species generation and promoter hypermethylation. This study demonstrates for the first time that nickel induces EMT in bronchial epithelial cells. PMID:22648416

76 FR 18930 - Medicare Programs: Changes to the End-Stage Renal Disease Prospective Payment System Transition...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Payment System Transition Budget-Neutrality Adjustment AGENCY: Centers for Medicare & Medicaid Services... comment will revise the end-stage renal disease (ESRD) transition budget-neutrality adjustment finalized... on April 1, 2011 through December 31, 2011. We are revising the transition budget-neutrality...

48 CFR 22.102-1 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

...; (d) Equal employment opportunity; (e) Child and convict labor; (f) Age discrimination; (g) Disabled... under United States immigration laws. [48 FR 42258, Sept. 19, 1983, as amended at 56 FR 55374, Oct. 25...

(2 + 1) resonant enhanced multiphoton ionization of H2 via the E,F 1Sigma(+)g state

NASA Technical Reports Server (NTRS)

Rudolph, H.; Lynch, D. L.; Dixit, S. N.; Mckoy, V.; Huo, Winifred M.

1987-01-01

In this paper, the results of ab initio calculations of photoelectron angular distributions and vibrational branching ratios for the (2 + 1) resonant enhanced multiphoton ionization (REMPI) of H2 via the E,F 1Sigma(+)g state are reported, and these are compared with the experimental data of Anderson et al. (1984). These results show that the observed non-Franck-Condon behavior is predominantly due to the R dependence of the transition matrix elements, and to a lesser degree to the energy dependence. This work presents the first molecular REMPI study employing a correlated wave function to describe the Rydberg-valence mixing in the resonant intermediate state.

Analysis of Rotationally Resolved Spectra to Non-Degenerate (a''_1) Upper-State Vibronic Levels in the tilde{A} ^2E''-tilde{X}^2A^'_2 Electronic Transition of NO_3

NASA Astrophysics Data System (ADS)

Roudjane, Mourad; Codd, Terrance Joseph; Chen, Ming-Wei; Tran, Henry; Melnik, Dmitry G.; Miller, Terry A.; Stanton, John F.

2015-06-01

The vibronic structure of the tilde{A}-tilde{X} electronic spectrum of NO_3 has been observed using both room-temperature and jet-cooled samples. A recent analysis of this structure is consistent with the Jahn-Teller effect (JTE) in the e^' ν_3 vibrational mode (N-O stretch) being quite strong while the JTE in the e^' ν_4 mode (O-N-O) bend) is rather weak. Electronic structure calculations qualitatively predict these results but the calculated magnitude of the JTE is quantitatively inconsistent with the spectral analysis. Rotationally resolved spectra have been obtained for over a dozen vibronic bands of the tilde{A}-tilde{X} electronic transition in NO_3. An analysis of these spectra should provide considerably more experimental information about the JTE in the tilde{A} state of NO_3 as the rotational structure should be quite sensitive to the geometric distortion of the molecule due to the JTE. This talk will focus upon the parallel bands, which terminate on tilde{A} state levels of a''_1 vibronic symmetry, which were the subject of a preliminary analysis reported at this meeting in 2014. We have now recorded the rotational structure of over a half-dozen parallel bands and have completed analysis on the 3^1_0 and 3^1_0 4^1_0 transitions with several other bands being reasonably well understood. Two general conclusions emerge from this work. (i) All the spectral bands show evidence of perturbations which can reasonably be assumed to result from interactions of the observed tilde{A} state levels with high vibrational levels of the tilde{X} state. The perturbations range from severe in some bands to quite modest in others. (ii) Analyses of observed spectra, insofar as the perturbations permit, have all been performed with an oblate symmetric top model including only additional spin-rotation effects. This result is, of course, consistent with an effective, undistorted geometry for NO_3 of D3h symmetry on the rotational timescale.

The E-Only Tipping Point for Journals: What's Ahead in the Print-to-Electronic Transition Zone

ERIC Educational Resources Information Center

Johnson, Richard K.; Luther, Judy

2007-01-01

This report examines the issues associated with moves toward electronic-only publication of journals, based on interviews with academic librarians and journal publishers. Noting that publishers and libraries today find themselves in an extended transition zone between print-only and e-only journals, the report investigates forces driving change…

26 CFR 1.42-12 - Effective dates and transitional rules.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 1.42-12 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Credits Against Tax § 1.42-12 Effective dates and transitional rules. (a) Effective dates—(1) In... to conform to the rules set forth in §§ 1.42-6 and 1.42-8 through 1.42-12. (2) Community Renewal Tax...

12 CFR Appendix E to Part 41 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

Code of Federal Regulations, 2010 CFR

2010-01-01

... that the information may be incorrectly reflected in a consumer report; thus, the furnished information... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 41 Banks... Furnished to Consumer Reporting Agencies Effective Date Note: At 74 FR 31512, July 1, 2009, appendix E was...

Characteristic length of glass transition

NASA Astrophysics Data System (ADS)

Donth, E.

1996-03-01

The characteristic length of the glass transition (ξ _α ) is based on the concept of cooperatively rearranging regions (CRR's) by Adam & Gibbs (1965): ξ _α is the diameter of one CRR. In the theoretical part of the talk a formula is derived how this length can be calculated from calorimetric data of the transformation interval. The approach is based on fluctuations in natural functional subsystems. The corresponding thermodynamics is represented e.g. in a book of the author (E. Donth, Relaxation and Thermodynamics in Polymers. Glass Transition, Akademie-Verlag, Berlin 1992). A typical value for this length is 3 nanometers. In the experimental part several examples are reported to enlarge the experimental evidence for such a length: Squeezing the glass transition in the amorphous layers of partially crystallized PET (C. Schick, Rostock), glass transition of small-molecule glass formers in a series of nanoscaled pores of porous glasses (F. Kremer, Leipzig), comparison with a concentration fluctuation model in homogeneous polymer mixtures (E.W. Fischer, Mainz), and, from our laboratory, backscaling to ξ _α across the main transition from the entanglement spacing in several amorphous polymers such as PVAC, PS, NR, and some polymer networks. Rouse backscaling was possible in the α β splitting region of several poly(n alkyl methacrylates) resulting in small characteristic lengths of order 1 nanometer near the onset of α cooperativity. In a speculative outlook a dynamic density pattern is presented, having a cellular structure with higher density and lower mobility of the cell walls. It will be explained, with the aid of different thermal expansion of wall and clusters, how the clusters within the cells maintain a certain mobility far below the glass temperature.

Structural signal of a dynamic glass transition

NASA Astrophysics Data System (ADS)

Chattopadhyay, Sudeshna; Uysal, Ahmet; Stripe, Benjamin; Evmenenko, Guennadi; Dutta, Pulak; Ehrlich, Steven; Karapetrova, Evguenia A.

2010-03-01

Conventional wisdom states that there is no significant difference between the static structures of the glass and liquid states of a given material. Using x-ray reflectivity, we have studied pentaphenyl trimethyl trisiloxane, an isotropic liquid at room temperature with a dynamic glass transition at 224K. Surface density oscillations (surface layers) develop below 285K, similar to those seen in other metallic and dielectric liquids and in computer simulations [1]. Upon cooling further, there is a sharp increase in the penetration of the surface layers into the bulk material, i.e. an apparently discontinuous change in the static structure, exactly at the glass transition (224K) [2]. [4pt] [1]. e.g. O. M. Magnussen et al., PRL 74, 4444 (1995); H. Mo et al. PRL 96, 096107 (2006); E. Chac'on et al., PRL 87, 166101 (2001) [0pt] [2] S. Chattopadhyay et al, PRL 103, 175701 (2009)

75 FR 366 - Notice of Agreement Filed

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... vessel space in the trade between the U.S. ports and ports in Malaysia, Vietnam, Japan, Korea, People's... the Commission's Web site ( http://www.fmc.gov ) or by contacting the Office of Agreements at (202... Commission. Dated: December 31, 2009. Tanga S. FitzGibbon, Assistant Secretary. [FR Doc. E9-31371 Filed 1-4...

75 FR 57846 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1... installation, with replacement as necessary for Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1...

The Spitzer search for the transits of HARPS low-mass planets. II. Null results for 19 planets

NASA Astrophysics Data System (ADS)

Gillon, M.; Demory, B.-O.; Lovis, C.; Deming, D.; Ehrenreich, D.; Lo Curto, G.; Mayor, M.; Pepe, F.; Queloz, D.; Seager, S.; Ségransan, D.; Udry, S.

2017-05-01

Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of objects suitable for detailed characterization. Searching for the transits of the low-mass planets detected by Doppler surveys is a straightforward way to achieve this goal. Indeed, Doppler surveys target the most nearby main-sequence stars, they regularly detect close-in low-mass planets with significant transit probability, and their radial velocity data constrain strongly the ephemeris of possible transits. In this context, we initiated in 2010 an ambitious Spitzer multi-Cycle transit search project that targeted 25 low-mass planets detected by radial velocity, focusing mainly on the shortest-period planets detected by the HARPS spectrograph. We report here null results for 19 targets of the project. For 16 planets out of 19, a transiting configuration is strongly disfavored or firmly rejected by our data for most planetary compositions. We derive a posterior probability of 83% that none of the probed 19 planets transits (for a prior probability of 22%), which still leaves a significant probability of 17% that at least one of them does transit. Globally, our Spitzer project revealed or confirmed transits for three of its 25 targeted planets, and discarded or disfavored the transiting nature of 20 of them. Our light curves demonstrate for Warm Spitzer excellent photometric precisions: for 14 targets out of 19, we were able to reach standard deviations that were better than 50 ppm per 30 min intervals. Combined with its Earth-trailing orbit, which makes it capable of pointing any star in the sky and to monitor it continuously for days, this work confirms Spitzer as an optimal instrument to detect sub-mmag-deep transits on the bright nearby stars targeted by Doppler surveys. The photometric and radial velocity time series used in this work are only available at the

26 CFR 1.1368-4 - Effective date and transition rule.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Effective date and transition rule. 1.1368-4 Section 1.1368-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Small Business Corporations and Their Shareholders § 1.1368-4 Effective...

Transiting exoplanets from the CoRoT space mission. XI. CoRoT-8b: a hot and dense sub-Saturn around a K1 dwarf

NASA Astrophysics Data System (ADS)

Bordé, P.; Bouchy, F.; Deleuil, M.; Cabrera, J.; Jorda, L.; Lovis, C.; Csizmadia, S.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Benz, W.; Bonomo, A. S.; Bruntt, H.; Carone, L.; Carpano, S.; Deeg, H.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Guenther, E.; Guillot, T.; Guterman, P.; Hatzes, A.; Havel, M.; Hébrard, G.; Lammer, H.; Léger, A.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pepe, F.; Ollivier, M.; Queloz, D.; Rauer, H.; Rouan, D.; Samuel, B.; Santerne, A.; Schneider, J.; Tingley, B.; Udry, S.; Weingrill, J.; Wuchterl, G.

2010-09-01

Aims: We report the discovery of CoRoT-8b, a dense small Saturn-class exoplanet that orbits a K1 dwarf in 6.2 days, and we derive its orbital parameters, mass, and radius. Methods: We analyzed two complementary data sets: the photometric transit curve of CoRoT-8b as measured by CoRoT and the radial velocity curve of CoRoT-8 as measured by the HARPS spectrometer. Results: We find that CoRoT-8b is on a circular orbit with a semi-major axis of 0.063 ± 0.001 AU. It has a radius of 0.57 ± 0.02 RJ, a mass of 0.22 ± 0.03 MJ, and therefore a mean density of 1.6 ± 0.1 g cm-3. Conclusions: With 67% of the size of Saturn and 72% of its mass, CoRoT-8b has a density comparable to that of Neptune (1.76 g cm-3). We estimate its content in heavy elements to be 47-63 {M}_⊕, and the mass of its hydrogen-helium envelope to be 7-23 {M}_⊕. At 0.063 AU, the thermal loss of hydrogen of CoRoT-8b should be no more than 0.1% over an assumed integrated lifetime of 3 Ga. Observations made with SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07B.MOUT), and the HARPS spectrograph at ESO La Silla Observatory (081.C-0388 and 083.C-0186). The CoRoT space mission, launched on December 27, 2006, has been developed and is operated by the CNES with the contribution of Austria, Belgium, Brasil, ESA, Germany, and Spain.Both data sets are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/520/A66

The Avahan Transition: Effects of Transition Readiness on Program Institutionalization and Sustained Outcomes

PubMed Central

Singh, Suneeta; Singh, Kriti; Chhabra, Vibha; Bennett, Sara

2016-01-01

Background With declines in development assistance for health and growing interest in country ownership, donors are increasingly faced with the task of transitioning health programs to local actors towards a path to sustainability. Yet there is little available guidance on how to measure and evaluate the success of a transition and its subsequent effects. This study assesses the transition of the Avahan HIV/AIDS prevention program in India to investigate how preparations for transition affected continuation of program activities post-transition. Methods Two rounds of two surveys were conducted and supplemented by data from government and Avahan Computerized Management Information Systems (CMIS). Exploratory factor analysis was used to develop two measures: 1) transition readiness pre-transition, and 2) institutionalization (i.e. integration of initial program systems into organizational procedures and behaviors) post-transition. A fixed effects model was built to examine changes in key program delivery outcomes over time. An ordinary least square regression was used to assess the relationship between transition readiness and sustainability of service outcomes both directly, and indirectly through institutionalization. Results Transition readiness data revealed 3 factors (capacity, alignment and communication), on a 15-item scale with adequate internal consistency (alpha 0.73). Institutionalization was modeled as a unidimensional construct, and a 12-item scale demonstrated moderate internal consistency (alpha 0.60). Coverage of key populations and condom distribution were sustained compared to pre-transition levels (p<0.01). Transition readiness, but not institutionalization, predicted sustained outcomes post-transition. Transition readiness did not necessarily lead to institutionalization of key program elements one year after transition. Conclusion Greater preparedness prior to transition is important to achieve better service delivery outcomes post-transition

76 FR 63537 - Mandatory Electronic Filing for Agencies and Attorneys at Washington Regional Office and Denver...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... believes e-filing would create an undue burden may request an exemption from the administrative [email protected] . SUPPLEMENTARY INFORMATION: 1. History of MSPB's E-Filing Initiative On February 26, 2008, MSPB issued final regulations at 5 CFR parts 1201, 1203, 1208, and 1209 governing e-filing. 73 FR 10127...

Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1.

PubMed

Carriere, Patrick P; Llopis, Shawn D; Naiki, Anna C; Nguyen, Gina; Phan, Tina; Nguyen, Mary M; Preyan, Lynez C; Yearby, Letitia; Pratt, Jamal; Burks, Hope; Davenport, Ian R; Nguyen, Thu A; Parker-Lemieux, KiTani; Payton-Stewart, Florastina; Williams, Christopher C; Boué, Stephen M; Burow, Matthew E; Collins-Burow, Bridgette; Hilliard, Aaron; Davidson, A Michael; Tilghman, Syreeta L

2015-12-22

Although aromatase inhibitors are standard endocrine therapy for postmenopausal women with early-stage metastatic estrogen-dependent breast cancer, they are limited by the development of drug resistance. A better understanding of this process is critical towards designing novel strategies for disease management. Previously, we demonstrated a global proteomic signature of letrozole-resistance associated with hormone-independence, enhanced cell motility and implications of epithelial mesenchymal transition (EMT). Letrozole-resistant breast cancer cells (LTLT-Ca) were treated with a novel phytoalexin, glyceollin I, and exhibited morphological characteristics synonymous with an epithelial phenotype and decreased proliferation. Letrozole-resistance increased Zinc Finger E-Box Binding Homeobox 1 (ZEB1) expression (4.51-fold), while glyceollin I treatment caused a -3.39-fold reduction. Immunofluorescence analyses resulted of glyceollin I-induced increase and decrease in E-cadherin and ZEB1, respectively. In vivo studies performed in ovariectomized, female nude mice indicated that glyceollin treated tumors stained weakly for ZEB1 and N-cadherin and strongly for E-cadherin. Compared to letrozole-sensitive cells, LTLT-Ca cells displayed enhanced motility, however in the presence of glyceollin I, exhibited a 68% and 83% decrease in invasion and migration, respectively. These effects of glyceollin I were mediated in part by inhibition of ZEB1, thus indicating therapeutic potential of glyceollin I in targeting EMT in letrozole resistant breast cancer.

Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1

PubMed Central

Carriere, Patrick P.; Llopis, Shawn D.; Naiki, Anna C.; Nguyen, Gina; Phan, Tina; Nguyen, Mary M.; Preyan, Lynez C.; Yearby, Letitia; Pratt, Jamal; Burks, Hope; Davenport, Ian R.; Nguyen, Thu A.; Parker-Lemieux, KiTani; Payton-Stewart, Florastina; Williams, Christopher C.; Boué, Stephen M.; Burow, Matthew E.; Collins-Burow, Bridgette; Hilliard, Aaron; Davidson, A. Michael; Tilghman, Syreeta L.

2015-01-01

Although aromatase inhibitors are standard endocrine therapy for postmenopausal women with early-stage metastatic estrogen-dependent breast cancer, they are limited by the development of drug resistance. A better understanding of this process is critical towards designing novel strategies for disease management. Previously, we demonstrated a global proteomic signature of letrozole-resistance associated with hormone-independence, enhanced cell motility and implications of epithelial mesenchymal transition (EMT). Letrozole-resistant breast cancer cells (LTLT-Ca) were treated with a novel phytoalexin, glyceollin I, and exhibited morphological characteristics synonymous with an epithelial phenotype and decreased proliferation. Letrozole-resistance increased Zinc Finger E-Box Binding Homeobox 1 (ZEB1) expression (4.51-fold), while glyceollin I treatment caused a −3.39-fold reduction. Immunofluorescence analyses resulted of glyceollin I-induced increase and decrease in E-cadherin and ZEB1, respectively. In vivo studies performed in ovariectomized, female nude mice indicated that glyceollin treated tumors stained weakly for ZEB1 and N-cadherin and strongly for E-cadherin. Compared to letrozole-sensitive cells, LTLT-Ca cells displayed enhanced motility, however in the presence of glyceollin I, exhibited a 68% and 83% decrease in invasion and migration, respectively. These effects of glyceollin I were mediated in part by inhibition of ZEB1, thus indicating therapeutic potential of glyceollin I in targeting EMT in letrozole resistant breast cancer. PMID:26703648