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Sample records for fr kommunikation om

  1. Kommunikation mit Mitarbeitern

    NASA Astrophysics Data System (ADS)

    Spychala, Anne; Fleischmann, Jürgen

    Kommunikation ist der Austausch von Nachrichten und Informationen zwischen Mitarbeitern eines Unternehmens (O'Hair et al. 1997). Dieser Austausch kann persönlich, aber z.B. auch per Telefon, E-Mail oder durch Computersysteme erfolgen. In diesem Kapitel betrachten wir die persönliche Kommunikation zwischen Vorgesetzten und Mitarbeitern. Zur persönlichen Kommunikation mit Mitarbeitern zählen sowohl formelle Gespräche mit Mitarbeitern als auch eher informelle Gespräche zwischen Tür und Angel. Die Gespräche können dabei mit einzelnen Mitarbeitern (z.B. jährliches Mitarbeitergespräch) oder mit Gruppen von Mitarbeitern (z.B. regelmäßige Projekt- oder Teambesprechungen) stattfinden.

  2. Transparente protokollierbare Kommunikation zwischen Funktionen kognitiver Systeme

    NASA Astrophysics Data System (ADS)

    Goebl, Matthias; Färber, Georg

    In kognitiven Systemen werden komplexe Entscheidungen getroffen, die ein umfassendes Umfeldverständnis erfordern. Technische Realisierungen sind meist datenintensiv und bestehen aus vielen Teilfunktionen. Um solche Systeme zu überwachen und neue Funktionen zu testen ist eine transparente und verfolgbare Kommunikation notwendig. Dieser Beitrag präsentiert einen datenzentrierten Ansatz zur Kommunikation und liefert eine Methode um alle Kommunikationsbeziehungen zu beobachten und ganzheitlich aufzuzeichnen. Ausgewählte Anwendungen demonstrieren die erzielten Ergebnisse.

  3. Kommunikation

    NASA Astrophysics Data System (ADS)

    Raulf, Hans-Ulrich

    Nicht erst seit der Entwicklung des SHELL-Modells durch Hawkins (1987) wird akzeptiert, dass die Leistung einer Cockpit-Crew von den zwischenmenschlichen Beziehungen der einzelnen Crewmitglieder abhängig ist.

  4. OMS 1987 Annual Report.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    Designed to serve both as an activity report on Office of Management Studies (OMS) progress during 1987 and a catalog of OMS services and products, this annual report focuses on the management of technology in a scholarly environment. Programs and services are reported in five sections: (1) Applied Research and Development (the Institute on…

  5. Einsatz einer Echtzeit-Publish/Subscribe-Kommunikation für die Teleoperation mobiler Roboter

    NASA Astrophysics Data System (ADS)

    Lindhorst, Timo; Herms, André; Schulze, Michael

    In der Telerobotik werden mobile Roboter über ein Kommunikationsnetz durch einen Operator ferngesteuert. Um interaktiv zu operieren, mussen Daten in beide Richtungen in Echtzeit kommuniziert werden. Zusätzlich ist eine hohe Ausfallsicherheit des Systems zu gewährleisten. Diese Arbeit beschreibt die Umsetzung ernes solchen Szenarios unter Verwendung einer Echtzeit-Publish/Subscribe-Kommunikation. Ein drahtloses Mesh-Netzwerk erfüllt durch redundante Verbindungen die Anforderungen an die Kommunikation. Eine Publish/Subscribe-Middleware ermöglicht eine inhaltsbasierte Kommunikation und erlaubt dadurch eine hohe Flexibilität der Teilnehmer. Durch die modulare Software-Architektur der Applikationen entsteht ein verteiltes System, in dem mobile Roboter durch netzwerktransparente Kommunikation gesteuert werden.

  6. 77 FR 41399 - EC&R O&M, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission EC&R O&M, LLC; Supplemental Notice That Initial Market-Based Rate Filing...-referenced proceeding of EC&R O&M, LLC's application for market-based rate authority, with an...

  7. OMS Annual Report, 1985.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This report describes the following 1985 Office of Management Studies (OMS) programs and services: (1) the Academic Library Program (ALP), which includes the Organizational Screening Program, the Collection Analysis Project (CAP), the Preservation Planning Program (PPP), the Public Services Study (PSS), the Management Review and Analysis Program…

  8. OMS Annual Report, 1983.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This report describes 1983 Office of Management Studies (OMS) programs and services, including: (1) the Academic Library Program (ALP), which covered the Public Services Project, the Collection Analysis Project (CAP), the Small College Collection Assessment Project, the Preservation Planning Program, the Organizational Screening Program, the…

  9. OMS Annual Report, 1983.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This report describes 1983 Office of Management Studies (OMS) programs and services, including: (1) the Academic Library Program (ALP), which covered the Public Services Project, the Collection Analysis Project (CAP), the Small College Collection Assessment Project, the Preservation Planning Program, the Organizational Screening Program, the…

  10. OMS Annual Report, 1985.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This report describes the following 1985 Office of Management Studies (OMS) programs and services: (1) the Academic Library Program (ALP), which includes the Organizational Screening Program, the Collection Analysis Project (CAP), the Preservation Planning Program (PPP), the Public Services Study (PSS), the Management Review and Analysis Program…

  11. Stabilizer and OMS pods

    NASA Image and Video Library

    2011-03-07

    S133-E-011335 (7 March 2011) --- Space shuttle Discovery’s vertical stabilizer, orbital maneuvering system (OMS) pods, remote manipulator system/orbiter boom sensor system (RMS/OBSS) and payload bay are featured in this image photographed by an STS-133 crew member on the shuttle during flight day 12 activities. Earth's horizon and the blackness of space provide the backdrop for the scene. Photo credit: NASA or National Aeronautics and Space Administration

  12. OMS FDIR: Initial prototyping

    NASA Technical Reports Server (NTRS)

    Taylor, Eric W.; Hanson, Matthew A.

    1990-01-01

    The Space Station Freedom Program (SSFP) Operations Management System (OMS) will automate major management functions which coordinate the operations of onboard systems, elements and payloads. The objectives of OMS are to improve safety, reliability and productivity while reducing maintenance and operations cost. This will be accomplished by using advanced automation techniques to automate much of the activity currently performed by the flight crew and ground personnel. OMS requirements have been organized into five task groups: (1) Planning, Execution and Replanning; (2) Data Gathering, Preprocessing and Storage; (3) Testing and Training; (4) Resource Management; and (5) Caution and Warning and Fault Management for onboard subsystems. The scope of this prototyping effort falls within the Fault Management requirements group. The prototyping will be performed in two phases. Phase 1 is the development of an onboard communications network fault detection, isolation, and reconfiguration (FDIR) system. Phase 2 will incorporate global FDIR for onboard systems. Research into the applicability of expert systems, object-oriented programming, fuzzy sets, neural networks and other advanced techniques will be conducted. The goals and technical approach for this new SSFP research project are discussed here.

  13. OMS engine firing

    NASA Technical Reports Server (NTRS)

    1983-01-01

    An Orbital maneuvering system (OMS) engine firing caused this bright glow at the aft end of the shuttle Challenger during STS-7. Also visible in the open payload bay are parts of the Shuttle pallet satellite (SPAS-01), the experiment package for NASA's Office of Space and Terrestrial Applications (OSTA-2), the protective cradles for the Indonesian Palapa-B and Telesat Canada Anik C2 satellites, some getaway special (GAS) canisters and the Canadian built remote manipulator system (RMS). Only a small portion of the earth's horizon can be seen above the orbiter's vertical stabilizer.

  14. OMS engine firing

    NASA Technical Reports Server (NTRS)

    1983-01-01

    An Orbital maneuvering system (OMS) engine firing caused this bright glow at the aft end of the shuttle Challenger during STS-7. Also visible in the open payload bay are parts of the Shuttle pallet satellite (SPAS-01), the experiment package for NASA's Office of Space and Terrestrial Applications (OSTA-2), the protective cradles for the Indonesian Palapa-B and Telesat Canada Anik C2 satellites, some getaway special (GAS) canisters and the Canadian built remote manipulator system (RMS). The earth's horizon can be seen above the orbiter.

  15. OMS engine firing

    NASA Image and Video Library

    1983-06-25

    S83-35782 (18 June 1983) --- An Orbital Maneuvering System (OMS) engine firing caused this bright glow at the aft end of the Earth-orbiting space shuttle Challenger on June 18, 1983. Also visible in the 70mm exposure are parts of the Shuttle Pallet Satellite (SPAS-01). The experiment package for NASA's Office of Space and Terrestrial Applications (OSTA-2), the protective cradles for the Indonesian Palapa-B and Telesat Canada Anik C2 satellites, some getaway special (GAS) canisters and the Canadian-built Remote Manipulator System (RMS). The firing took place less than an hour after deployment of Anik. Photo credit: NASA

  16. Two Papers on "Fag(sprog)lig Kommunikation" (Language for Specific Purposes). ROLIG-papir 46.

    ERIC Educational Resources Information Center

    Henriksen, Carol

    Two papers on "fag(sprog)lig Kommunikation"--languages for special purposes (LSP)--are presented. The first paper, in Danish, presents an alternative to the current structuralist oriented approach to the analysis of LSP as a kind of language in its own right and of texts written in this special kind of language. The approach is based on a more…

  17. Orbiter OMS and RCS technology

    NASA Technical Reports Server (NTRS)

    Boudreaux, R. A.

    1982-01-01

    Orbiter Orbital Maneuver Subsystem (OMS) and Reaction Control Subsystem (RCS) tankage has proved to be highly successful in shuttle flights on-orbit propellant transfer tests were done. Tank qualification tests along with flight demonstrations were carried out future uses of storable propellants are cited.

  18. OMS event evaluator and scheduler

    NASA Technical Reports Server (NTRS)

    Eckelkamp, Richard E.

    1990-01-01

    An Operations Management System (OMS) is being designed for Space Station Freedom to improve productivity, reliability, and safety while reducing operations and maintenance costs. Central to the concept is a short term plan containing mixes of man-readable and machine-executable procedures used in an environment of distributed processing and execution. An OMS event evaluator to check upcoming short-term plan events for validity of execution is under development. The first version checks time and resource constraints against operational conditions for current or expected stations. In work are the handling of environmental and other operational constraints, as well as detailed modeling of resources and station operational states. The Ada Program also has the ability to reschedule all or part of the events.

  19. OM300 Direction Drilling Module

    DOE Data Explorer

    MacGugan, Doug

    2013-08-22

    OM300 – Geothermal Direction Drilling Navigation Tool: Design and produce a prototype directional drilling navigation tool capable of high temperature operation in geothermal drilling Accuracies of 0.1° Inclination and Tool Face, 0.5° Azimuth Environmental Ruggedness typical of existing oil/gas drilling Multiple Selectable Sensor Ranges High accuracy for navigation, low bandwidth High G-range & bandwidth for Stick-Slip and Chirp detection Selectable serial data communications Reduce cost of drilling in high temperature Geothermal reservoirs Innovative aspects of project Honeywell MEMS* Vibrating Beam Accelerometers (VBA) APS Flux-gate Magnetometers Honeywell Silicon-On-Insulator (SOI) High-temperature electronics Rugged High-temperature capable package and assembly process

  20. On-Orbit Propulsion OMS/RCS

    NASA Technical Reports Server (NTRS)

    Hurlbert, Eric A.

    2001-01-01

    This slide presentation reviews the Space Shuttle's On-Orbit Propulsion systems: the Orbital Maneuvering System (OMS) and the Reaction Control System (RCS). The functions of each of the systems is described, and the diagrams of the systems are presented. The OMS/RCS thruster is detailed and a trade study comparison of non-toxic propellants is presented.

  1. Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5.

    PubMed

    Volland, Sonja; Rachinger, Michael; Strittmatter, Axel; Daniel, Rolf; Gottschalk, Gerhard; Meyer, Ortwin

    2011-09-01

    We report on genome sequencing of Oligotropha carboxidovorans strain OM4 and resequencing of strain OM5. The genomes of both are composed of one chromosome and two plasmids. The presence of two plasmids in the OM5 genome is inconsistent with the previously published sequence, for which only one plasmid was described (D. Paul, S. Bridges, S. Burgess, Y. Dandass, and M. Lawrence, BMC Genomics 11:511, 2010). Copyright © 2011, American Society for Microbiology. All Rights Reserved.

  2. Overtone mobility spectrometry: part 4. OMS-OMS analyses of complex mixtures.

    PubMed

    Kurulugama, Ruwan T; Nachtigall, Fabiane M; Valentine, Stephen J; Clemmer, David E

    2011-11-01

    A new, two-dimensional overtone mobility spectrometry (OMS-OMS) instrument is described for the analysis of complex peptide mixtures. OMS separations are based on the differences in mobilities of ions in the gas phase. The method utilizes multiple drift regions with modulated drift fields such that only ions with appropriate mobilities are transmitted to the detector. Here we describe a hybrid OMS-OMS combination that utilizes two independently operated OMS regions that are separated by an ion activation region. Mobility-selected ions from the first OMS region are exposed to energizing collisions and may undergo structural transitions before entering the second OMS region. This method generates additional peak capacity and allows for higher selectivity compared with the one-dimensional OMS method. We demonstrate the approach using a three-protein tryptic digest spiked with the peptide Substance P. The [M + 3H](3+) ion from Substance P can be completely isolated from other components in this complex mixture prior to introduction into the mass spectrometer.

  3. Overtone Mobility Spectrometry: Part 4. OMS-OMS Analyses of Complex Mixtures

    PubMed Central

    Kurulugama, Ruwan T.; Nachtigall, Fabiane M.; Valentine, Stephen J.; Clemmer, David E.

    2013-01-01

    A new, two-dimensional overtone mobility spectrometry (OMS-OMS) instrument is described for the analysis of complex peptide mixtures. OMS separations are based on the differences in mobilities of ions in the gas phase. The method utilizes multiple drift regions with modulated drift fields such that only ions with appropriate mobilities are transmitted to the detector. Here we describe a hybrid OMS-OMS combination that utilizes two independently operated OMS regions that are separated by an ion activation region. Mobility-selected ions from the first OMS region are exposed to energizing collisions and may undergo structural transitions before entering the second OMS region. This method generates additional peak capacity and allows for higher selectivity compared with the one-dimensional OMS method. We demonstrate the approach using a three-protein tryptic digest spiked with the peptide Substance P. The [M+3H]3+ ion from Substance P can be completely isolated from other components in this complex mixture prior to introduction into the mass spectrometer. PMID:21952760

  4. [Assessment of the Polish occupational medicine service (oms) system made by OMS nurses].

    PubMed

    Sakowski, Piotr

    2012-01-01

    This paper presents the results of an assessment of the Polish occupational medicine service (OMS) system made by OMS nurses. The survey was carried out on a random group of OMS nurses. OMS nurses form a professional group comprised of rather experienced personnel. In the opinion of almost 70% of respondents the system guarantees good occupational heath care, whereas 20% took the opposite view. The great majority of respondents think that all employees have to undergo mandatory prophylactic examinations. The nurses have rather critical opinion about the legal regulations pertaining to occupational health care--their number and complexity, and also express negative opinion about the quality of cooperation with employers (who are contractors for OMS units). OMS nurses believe that prophylactic examinations are the strongest point of the system. They are often the only opportunity for establishing contact between an employee and a physician and learning about diseases he or she was previously unaware of. Although the general assessment of the OMS system is rather positive, it is not free of shortcomings. Improvements in such fields as legislation, financing of service, professional attitude towards responsibilities of the OMS staff, cooperation with employers (contractors) and primary health care units would undoubtedly result in even better assessment, and what is more important in better functioning of the Polish OMS system.

  5. Overtone Mobility Spectrometry: Part 4. OMS-OMS Analyses of Complex Mixtures

    NASA Astrophysics Data System (ADS)

    Kurulugama, Ruwan T.; Nachtigall, Fabiane M.; Valentine, Stephen J.; Clemmer, David E.

    2011-11-01

    A new, two-dimensional overtone mobility spectrometry (OMS-OMS) instrument is described for the analysis of complex peptide mixtures. OMS separations are based on the differences in mobilities of ions in the gas phase. The method utilizes multiple drift regions with modulated drift fields such that only ions with appropriate mobilities are transmitted to the detector. Here we describe a hybrid OMS-OMS combination that utilizes two independently operated OMS regions that are separated by an ion activation region. Mobility-selected ions from the first OMS region are exposed to energizing collisions and may undergo structural transitions before entering the second OMS region. This method generates additional peak capacity and allows for higher selectivity compared with the one-dimensional OMS method. We demonstrate the approach using a three-protein tryptic digest spiked with the peptide Substance P. The [M + 3H]3+ ion from Substance P can be completely isolated from other components in this complex mixture prior to introduction into the mass spectrometer.

  6. OMS, OM(η2-SO), and OM(η2-SO)(η2-SO2) molecules (M = Ti, Zr, Hf): infrared spectra and density functional calculations.

    PubMed

    Liu, Xing; Wang, Xuefeng; Wang, Qiang; Andrews, Lester

    2012-07-02

    Infrared spectra of the matrix isolated OMS, OM(η(2)-SO), and OM(η(2)-SO)(η(2)-SO(2)) (M = Ti, Zr, Hf) molecules were observed following laser-ablated metal atom reactions with SO(2) during condensation in solid argon and neon. The assignments for the major vibrational modes were confirmed by appropriate S(18)O(2) and (34)SO(2) isotopic shifts, and density functional vibrational frequency calculations (B3LYP and BPW91). Bonding in the initial OM(η(2)-SO) reaction products and in the OM(η(2)-SO)(η(2)-SO(2)) adduct molecules with unusual chiral structures is discussed.

  7. Effects of complexation between organic matter (OM) and clay mineral on OM pyrolysis

    NASA Astrophysics Data System (ADS)

    Bu, Hongling; Yuan, Peng; Liu, Hongmei; Liu, Dong; Liu, Jinzhong; He, Hongping; Zhou, Junming; Song, Hongzhe; Li, Zhaohui

    2017-09-01

    The stability and persistence of organic matter (OM) in source rocks are of great significance for hydrocarbon generation and the global carbon cycle. Clay-OM associations commonly occur in sedimentation and diagenesis processes and can influence the pyrolytic behaviors of OM. In this study, clay-OM complexes, i.e., interlayer clay-OM complexes and clay-OM mixture, were prepared and exposed to high-pressure pyrolysis conditions in confined gold capsule reactors to assess variations in OM pyrolysis products in the presence of clay minerals. Three model organic compounds, octadecanoic acid (OA), octadecy trimethyl ammonium bromide (OTAB), and octadecylamine (ODA), were employed and montmorillonite (Mt) was selected as the representative clay mineral. The solid acidity of Mt plays a key role in affecting the amount and composition of the pyrolysis gases generated by the clay-OM complexes. The Brønsted acid sites significantly promote the cracking of hydrocarbons through a carbocation mechanism and the isomerization of normal hydrocarbons. The Lewis acid sites are primarily involved in the decarboxylation reaction during pyrolysis and are responsible for CO2 generation. Mt exhibits either a catalysis effect or pyrolysis-inhibiting during pyrolysis of a given OM depending on the nature of the model organic compound and the nature of the clay-OM complexation. The amounts of C1-5 hydrocarbons and CO2 that are released from the Mt-OA and Mt-ODA complexes were higher than those of the parent OA and ODA, respectively, indicating a catalysis effect of Mt. In contrast, the amount of C1-5 hydrocarbons produced from the pyrolysis of Mt-OTAB complexes was lower than that of OTAB, which we attribute to an inhibiting effect of Mt. This pyrolysis-inhibiting effect works through the Hoffmann elimination that is promoted by the catalysis of the Brønsted acid sites of Mt, therefore releasing smaller amounts of gas hydrocarbons than the nucleophilic reaction that is induced by the

  8. The O&M Personnel Shortage and University Training Programs.

    ERIC Educational Resources Information Center

    Wiener, William R.; Joffee, Elga

    1993-01-01

    Measures taken during the 1980s to increase the number of orientation and mobility (O&M) specialists to work with persons with visual impairments were evaluated, by means of a telephone survey of 15 university O&M programs. Survey findings indicated that efforts to address critical shortages in O&M personnel have been effective. (DB)

  9. 20 CFR 229.52 - Age reduction when a reduced age O/M is effective before DIB O/M.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Age reduction when a reduced age O/M is... Minimum Rate § 229.52 Age reduction when a reduced age O/M is effective before DIB O/M. If an employee received a reduced age O/M before the effective date of a DIB O/M, the PIA amount for the DIB O/M...

  10. STS-39: OMS Pod Thruster Removal/Replace

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Shown is the removal and replacement of the Discovery's orbital maneuvering systems (OMS) pod thruster. The OMS engine will be used to propel Discovery north, off of its previous orbital groundtrack, without changing the spacecraft's altitude. A burn with this lateral effect is known as "out-of-plane."

  11. View of OMS burn from the payload bay

    NASA Technical Reports Server (NTRS)

    1982-01-01

    View of Orbital Maneuvering System (OMS) burn from the payload bay. The closed cradles which held the communication satellites Columbia deployed are visible in the center of the frame. Parts of the spacecraft's wings can be seen on both the port and starboard sides can be seen. The vertical stabilizer is flanked by the twin OMS pods.

  12. View of OMS burn and illuminated orbiter stabilizer

    NASA Image and Video Library

    1997-05-16

    STS084-357-008 (15-24 May 1997) --- Photographed through the aft flight deck windows of the Earth-orbiting Space Shuttle Atlantis, this 35mm frame captures a firing of the Orbital Maneuvering System (OMS) engines to perform a necessary maneuver. The vertical stabilizer, flanked by the two OMS pods, is illuminated in the scene.

  13. Shuttle performance enhancements using an OMS payload bay kit

    NASA Technical Reports Server (NTRS)

    Templin, Kevin C.; Mallini, Charles J.

    1991-01-01

    The study focuses on the use of an orbital maneuvering system (OMS) payload bay kit (PBK) designed to utilize OMS tanks identical to those currently employed in the Orbiter OMS pods. Emphasis is placed on payload deployment capability and payload servicing/reboost capability augmentation from the point of view of payload mass, maximum deployment altitudes, and initial retrieval and final deployment altitudes. The deployment, servicing, and reboost requirements of the Hubble Space Telescope and Advanced X-ray and Astrophysics Facility are analyzed in order to show the benefits an OMS PBK can provide for these missions. It is shown that OMS PBKs can provide the required capability enhancement necessary to support deployment, reboost, and servicing of payloads requiring altitudes greater than 325 nautical miles.

  14. ométrie de Roche

    NASA Astrophysics Data System (ADS)

    Hameury, Jean-Marie

    2001-01-01

    I discuss here the geometry of a close binary, described by the Roche potential. The three possible solutions, detached, semi-detached and contact systems, are presented. Ellipsoidal variations found in quiescent soft X-ray transients show that the secondary distortion is indeed quite detectable; they also can be used to constrain the primary mass, and, together with the spectroscopic determination of the mass function, are the only unambiguous evidences for the existence of black holes in LMXBs. Ce chapitre détaille la géométrie d'un système binaire serré, décrite par le potentiel de Roche. Les trois possibilités (système détaché, semi-détaché, en contact) sont présentées. Les variations ellipsoídales observées dans les systèmes transitoires X en quiescence montrent que les déformations de la secondaire sont parfaitement détectables elles permettent surtout de contraindre la masse de l'objet compact, et fournissent, avec la détermination par spectroscopie de la fonction de masse, les seules preuves indiscutables de l'existence de trous noirs dans les systèmes binaires X.

  15. Saccharomyces cerevisiae Porin Pore Forms Complexes with Mitochondrial Outer Membrane Proteins Om14p and Om45p

    PubMed Central

    Lauffer, Susann; Mäbert, Katrin; Czupalla, Cornelia; Pursche, Theresia; Hoflack, Bernard; Rödel, Gerhard; Krause-Buchholz, Udo

    2012-01-01

    Numerous transport processes occur between the two mitochondrial (mt) membranes due to the diverse functions and metabolic processes of the mt organelle. The metabolite and ion transport through the mt outer membrane (OM) is widely assumed to be mediated by the porin pore, whereas in the mt inner membrane (IM) specific carriers are responsible for transport processes. Here, we provide evidence by means of Blue Native (BN)-PAGE analysis, co-immunoprecipitation, and tandem affinity purification that the two mt OM proteins Om14p and Om45p associate with the porin pore. Porin molecules seem to assemble independently to build the core unit. A subpopulation of these core units interacts with Om14p and Om45p. With preparative tandem affinity purification followed by MS analysis, we could identify interaction partners of this OM complex, which are mainly localized within the mt IM and function as carriers for diverse molecules. We propose a model for the role of the two OM proteins in addressing the porin pore to bind to specific channels in the mt IM to facilitate transport of metabolites. PMID:22461620

  16. Selective hydrogenation of halogenated arenes using porous manganese oxide (OMS-2) and platinum supported OMS-2 catalysts.

    PubMed

    McManus, Iain J; Daly, Helen; Manyar, Haresh G; Taylor, S F Rebecca; Thompson, Jillian M; Hardacre, Christopher

    2016-07-04

    Porous manganese oxide (OMS-2) and platinum supported on OMS-2 catalysts have been shown to facilitate the hydrogenation of the nitro group in chloronitrobenzene to give chloroaniline with no dehalogenation. Complete conversion was obtained within 2 h at 25 °C and, although the rate of reaction increased with increasing temperature up to 100 °C, the selectivity to chloroaniline remained at 99.0%. Use of Pd/OMS-2 or Pt/Al2O3 resulted in significant dechlorination even at 25 °C and 2 bar hydrogen pressure giving a selectivity to chloroaniline of 34.5% and 77.8%, respectively, at complete conversion. This demonstrates the potential of using platinum group metal free catalysts for the selective hydrogenation of halogenated aromatics. Two pathways were observed for the analogous nitrobenzene hydrogenation depending on the catalyst used. The hydrogenation of nitrobenzene was found to follow a direct pathway to aniline and nitrosobenzene over Pd/OMS-2 in contrast to the OMS and Pt/OMS-2 catalysts which resulted in formation of nitrosobenzene, azoxybenzene and azobenzene/hydrazobenzene intermediates before complete conversion to aniline. These results indicate that for Pt/OMS-2 the hydrogenation proceeds predominantly over the support with the metal acting to dissociate hydrogen. In the case of Pd/OMS-2 both the hydrogenation and hydrogen adsorption occur on the metal sites.

  17. Schichtübergreifende Früherkennung von Verbindungsausfällen in drahtlosen Mesh-Netzwerken

    NASA Astrophysics Data System (ADS)

    Lindhorst, Timo

    Drahtlose Mesh-Netzwerke (WMNs) bilden aufgrund ihrer Selbstorganisation ein flexibles Kommunikationssystem. Bei der Erkennung einzelner Verbindungsausfälle, die bei der Integration mobiler Teilnehmer unvermeidbar sind, ist bei aktuellen Routingprotokollen die Kommunikation jedoch für mehrere Sekunden unterbrochen. In dieser Arbeit wird gezeigt, wie durch Nutzung von Informationen aus der MAC-Schicht ein Ausfall frühzeitig erkannt und dadurch die Anzahl der Paketverluste von mehreren Hundert auf maximal vier reduziert werden kann. Hierdurch wird die Zuverlässigkeit und Verfügbarkeit von WMNs erhöht und ihr Einsatz für Echtzeit-Anwendungen ermöglicht.

  18. Glow phenomenon surrounding the vertical stabilizer and OMS pods

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This 35mm frame, photographed as the Space Shuttle Columbia was orbiting Earth during a 'night' pass, documents the glow phenomenon surrounding the vertical stabilizer and the Orbital Maneuvering System (OMS) pods of the spacecraft.

  19. User documentation for the MSK and OMS intelligent tutoring systems

    NASA Technical Reports Server (NTRS)

    Fink, Pamela K.; Herren, L. Tandy; Lincoln, David T.

    1991-01-01

    This user's guide describes how to use the Intelligent Tutoring Systems for the Manual Select Keyboard (MSK) and the Orbital Maneuvering System (OMS) and how to use the C code that runs the mockup version of the MSK.

  20. Glow phenomenon surrounding the vertical stabilizer and OMS pods

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This 35mm frame, photographed as the Space Shuttle Columbia was orbiting Earth during a 'night' pass, documents the glow phenomenon surrounding the vertical stabilizer and the Orbital Maneuvering System (OMS) pods of the spacecraft.

  1. OM-VPE grown materials for high efficiency solar cells

    NASA Technical Reports Server (NTRS)

    Saxena, R.; Cooper, B., III; Ludowise, M.; Borden, P.; Gregory, P.

    1980-01-01

    Organometallic sources are available for all the III-V elements and a variety of dopants; thus it is possible to use the technique to grow a wide variety of semiconductor compounds. AlGaAsSb and AlGaInAs alloys for multijunction monolithic solar cells were grown by OM-VPE. While the effort concentrated on terrestrial applications, the success of OM-VPE grown GaAs/AlGaAs concentrator solar cells (23% at 400 suns) demonstrates that OM-VPE is suitable for growing high efficiency solar cells in large quantities for space applications. In addition, OM-VPE offers the potential for substantial cost reduction of photovoltaic devices with scale up and automation and due to high process yield from reproducible, uniform epitaxial growths with excellent surface morphology.

  2. 43 CFR 426.23 - Recovery of operation and maintenance (O&M) costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Recovery of operation and maintenance (O&M... operation and maintenance (O&M) costs. (a) General. All new, amended, and renewed contracts shall provide for payment of O&M costs as specified in this section. (b) Amount of O&M costs a district must pay...

  3. 20 CFR 229.52 - Age reduction when a reduced age O/M is effective before DIB O/M.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Age reduction when a reduced age O/M is effective before DIB O/M. 229.52 Section 229.52 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS... Minimum Rate § 229.52 Age reduction when a reduced age O/M is effective before DIB O/M. If an...

  4. 20 CFR 229.52 - Age reduction when a reduced age O/M is effective before DIB O/M.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Age reduction when a reduced age O/M is effective before DIB O/M. 229.52 Section 229.52 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS... Minimum Rate § 229.52 Age reduction when a reduced age O/M is effective before DIB O/M. If an...

  5. Cambodian Bon Om Touk stampede highlights preventable tragedy.

    PubMed

    Hsu, Edbert B; Burkle, Frederick M

    2012-10-01

    The tragic nature of the human stampede that took place in Phnom Penh, Cambodia on November 22, 2010 claimed the lives of 347 people during the three-day-long Water Festival, known as Bon Om Touk. Described as the greatest tragedy that Cambodia has experienced since the collapse of the Khmer Rouge, the Bon Om Touk stampede ranks among the deadliest human stampede disasters during the past 30 years, a Class IV event exceeding 100 fatalities according to a recently proposed scale. 1 From the perspective of global health, the event shares many characteristics with preceding major crowd disasters and failures in event planning. It is essential for the international community to officially monitor human stampedes as it does other major disasters. Additional research on human stampedes is needed to improve our collective understanding of the causes of crowd disasters and how best to prevent them. Hsu EB , Burkle FM Jr . Cambodian Bon Om Touk stampede highlights preventable tragedy.

  6. OM Code Requirements For MOVs -- OMN-1 and Appendix III

    SciTech Connect

    Kevin G. DeWall

    2011-08-01

    The purpose or scope of the ASME OM Code is to establish the requirements for pre-service and in-service testing of nuclear power plant components to assess their operational readiness. For MOVs this includes those that perform a specific function in shutting down a reactor to the safe shutdown condition, maintaining the safe shutdown condition, and mitigating the consequences of an accident. This paper will present a brief history of industry and regulatory activities related to MOVs and the development of Code requirements to address weaknesses in earlier versions of the OM Code. The paper will discuss the MOV requirements contained in the 2009 version of ASME OM Code, specifically Mandatory Appendix III and OMN-1, Revision 1.

  7. Information und Kommunikation

    NASA Astrophysics Data System (ADS)

    Wesoly, Michael; Ohlhausen, Peter; Bucher, Michael; Hichert, Rolf; Korge, Gabriele; Schnabel, Ulrich; Gairola, Arun; Reichwald, Ralf; Habicht, Hagen; Möslein, Kathrin; Schwarz, Torsten; Schönsleben, Paul; Scherer, Eric; Schloske, Alexander; Adlbrecht, Gerald; Federhen, Jens

    Wissen ist mittlerweile unverzichtbar für den entscheidenden Vorsprung auf dem Markt. Unabhängig davon, ob sich das Wissen in Innovationen, neuen Produkten und Dienstleistungen oder in der Verbesserung interner Unternehmensprozesse manifestiert: Wissen ist Treiber von Innovation, Wissen bringt Schnelligkeit und Wissen ist die Voraussetzung für Problemlösungen [40]. Wissensmanagement ist daher der Schlüssel für Unternehmenserfolg und bezeichnet den "bewussten und systematischen Umgang mit der Ressource Wissen und den zielgerichteten Einsatz von Wissen in der Organisation“ [6]. In dieser umfassenden Sichtweise ist Wissensmanagement ein Begriff, der Konzepte, Strategien und Methoden umfasst.

  8. Kommunikation in Automatisierungssystemen

    NASA Astrophysics Data System (ADS)

    Wellenreuther, Günter; Zastrow, Dieter

    Die Automatisierungstechnik befindet sich im Umbruch. Durch Anwendung moderner Kommunikationstechnik erhofft man sich entscheidende Verbesserungen bei Effizienz und Flexibilität der Automatisierungsprozesse. Der Begriff der Automatisierungstechnik umfasst heute mehr als nur das Automatisieren im Sinne von Steuern, Regeln und Visualisieren, eingeschlossen ist auch das Kommunizieren.

  9. Space Shuttle OMS engine valve technology. [Orbital Maneuvering System

    NASA Technical Reports Server (NTRS)

    Wichmann, H.

    1974-01-01

    Valve technology program to determine shutoff valve concepts suitable for the Orbital Maneuvering System (OMS) engine of the Space Shuttle. The tradeoff studies selected the electric torque motor operated dual poppet and ball valves as the most desirable valve concepts for the OMS Engine Shutoff Valve. A prototype of one of these concepts was built and subjected to a design verification program. A number of unique features were designed to include the required contamination insensitivity, operating fluid compatibility, decontamination capability, minimum maintenance requirement and long service life capability.

  10. Activities of the O&M committee history & future perspectives

    SciTech Connect

    Poulis, D.S.

    1996-12-01

    This paper gives an overview of the Committee on Operation and Maintenance of Nuclear Power Plants, hereafter referred to as the O&M Committee, formed in June 1975 when the American National Standard Institute`s Committee on Reactor Plants and their Maintenance was disbanded. The O&M Committee`s history, structure, current focus and future perspectives will be presented. The purpose of this paper is to give information to industry and the public of the Committee`s on-going effort to make accurate and timely responses to the needs of the nuclear industry.

  11. Recapitulation of the ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos.

    PubMed

    Gao, Shaorong; Wu, Guangming; Han, Zhiming; de la Casa-Esperón, Elena; Sapienza, Carmen; Latham, Keith E

    2005-02-01

    The ovum mutant (Om) locus in mice affects early interactions between sperm and egg that in turn affect viability of embryos beyond the morula stage. Crosses of DDK females to males of many other inbred strains are 95% lethal around the morula stage, whereas reciprocal crosses are fully viable. Available data indicate that the early lethality is the result of an interaction between a factor in the ooplasm and the paternal genome. In this study, we examined whether this lethal interaction would likewise occur in cloned embryos produced by somatic cell nuclear transfer. We find that the Om effect is recapitulated but that the parental origin effect at the Om locus is no longer evident in cloned embryos.

  12. Operations and Maintenance Introductory O&M Newsletter | Poster

    Cancer.gov

    The Operations and Maintenance (O&M) department has been serving and supporting the NCI scientific mission since 1972. Our dedicated staff works 24/7 behind the scenes to ensure that the NCI campus and laboratory environments are safe, functional, and reliable, as well as comfortable and aesthetically pleasing.

  13. View of the firing of a single engine OMS

    NASA Image and Video Library

    1985-08-27

    View of a single engine orbital maneuvering system (OMS) firing on the Discovery. The payload bay is open and the protective canisters for the AUSSAT communications satellite (open) and the ASC-1 are visible. A cloudy Earth's horizon can be seen above the orbiter.

  14. View of the firing of a single engine OMS

    NASA Technical Reports Server (NTRS)

    1985-01-01

    View of a single engine orbital maneuvering system (OMS) firing on the Discovery. The payload bay is open and the protective canisters for the AUSSAT communications satellite (open) and the ASC-1 are visible. A cloudy Earth's horizon can be seen above the orbiter.

  15. Glow phenomenon surrounding the vertical stabilizer and OMS pods

    NASA Image and Video Library

    1994-03-05

    STS062-42-026 (4-18 March 1994) --- This 35mm frame, photographed as the Space Shuttle Columbia was orbiting Earth during a "night" pass, documents the glow phenomenon surrounding the vertical stabilizer and the Orbital Maneuvering System (OMS) pods of the spacecraft.

  16. Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie.

    PubMed

    Ben Abdelkrim, Soumaya; Rammeh, Soumaya; Trabelsi, Amel; Ben Yacoub-Abid, Lilia; Ben Sorba, Nabil; Jaïdane, Lilia; Mokni, Moncef

    2012-12-01

    RéSUMé: OBJECTIF : Déterminer les taux d'accord et la reproductibilité intra et inter-observateurs des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie. MATéRIEL ET MéTHODES : Cent deux cas de tumeurs urothéliales papillaires de stade pTa/pT1 ont été étudiés. Deux pathologistes ont revu les lames et ont établi le grade tumoral selon les deux classifications OMS 1973 et OMS 2004. En cas de désaccord, les deux évaluateurs ont procédé à une lecture commune au microscope en double tête afin d'aboutir à un grade consensuel selon les deux classifications. La variabilité intra-observateur a été étudiée chez l'un des deux évaluateurs qui a procédé à la relecture des lames un mois après sa première lecture. Les taux d'accord entre les deux pathologistes pour chaque catégorie de grade ont été déterminés et la reproductibilité des deux classifications a été évaluée à l'aide du coefficient kappa. Une valeur de 0 à 0,2 était interprétée comme un désaccord absolu, de 0,21 à 0,4, un accord faible, de 0,41 à 0,6, un accord modéré, de 0,61 à 0,8, un accord considérable, et de 0,8 à 1, un accord absolu. RéSULTATS : Selon la classification OMS 1973, les proportions des grades G1, G2 et G3 étaient respectivement de 40,2 %, 50 % et 9,8 %. Selon la classification OMS 2004, les proportions respectives des tumeurs de faible potentiel de malignité, des carcinomes de bas grade et des carcinomes de haut grade de malignité étaient de 23,5 %, 60,8 % et 15,7 %. La reproductibilité intra-observateur était excellente pour les deux classifications (accord absolu). Les taux d'accord entre les deux pathologistes étaient meilleurs pour la classification OMS 2004 (kappa = 0,7) que pour la classification OMS 1973 (kappa = 0,51). La reproductibilité entre observateurs de la classification OMS 2004 est supérieure à celle de 1973. La reproductibilité intra-observateur est excellente pour les deux

  17. Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie

    PubMed Central

    Ben Abdelkrim, Soumaya; Rammeh, Soumaya; Trabelsi, Amel; Ben Yacoub-Abid, Lilia; Ben Sorba, Nabil; Jaïdane, Lilia; Mokni, Moncef

    2012-01-01

    Résumé Objectif : Déterminer les taux d’accord et la reproductibilité intra et inter-observateurs des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie. Matériel et méthodes : Cent deux cas de tumeurs urothéliales papillaires de stade pTa/pT1 ont été étudiés. Deux pathologistes ont revu les lames et ont établi le grade tumoral selon les deux classifications OMS 1973 et OMS 2004. En cas de désaccord, les deux évaluateurs ont procédé à une lecture commune au microscope en double tête afin d’aboutir à un grade consensuel selon les deux classifications. La variabilité intra-observateur a été étudiée chez l’un des deux évaluateurs qui a procédé à la relecture des lames un mois après sa première lecture. Les taux d’accord entre les deux pathologistes pour chaque catégorie de grade ont été déterminés et la reproductibilité des deux classifications a été évaluée à l’aide du coefficient kappa. Une valeur de 0 à 0,2 était interprétée comme un désaccord absolu, de 0,21 à 0,4, un accord faible, de 0,41 à 0,6, un accord modéré, de 0,61 à 0,8, un accord considérable, et de 0,8 à 1, un accord absolu. Résultats : Selon la classification OMS 1973, les proportions des grades G1, G2 et G3 étaient respectivement de 40,2 %, 50 % et 9,8 %. Selon la classification OMS 2004, les proportions respectives des tumeurs de faible potentiel de malignité, des carcinomes de bas grade et des carcinomes de haut grade de malignité étaient de 23,5 %, 60,8 % et 15,7 %. La reproductibilité intra-observateur était excellente pour les deux classifications (accord absolu). Les taux d’accord entre les deux pathologistes étaient meilleurs pour la classification OMS 2004 (kappa = 0,7) que pour la classification OMS 1973 (kappa = 0,51). Conclusions : La reproductibilité entre observateurs de la classification OMS 2004 est supérieure à celle de 1973. La reproductibilité intra-observateur est

  18. ISAL experiment documentation of vertical tail and OMS pods

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Investigation of Space Transportation System (STS) Atmospheric Luminosities (ISAL) experiment documentation includes vertical tail and orbital maneuvering system (OMS) pods with surface glow against the blackness of space. This glowing scene was provided by a long duration exposure with a 35mm camera aimed toward the tail of the Earth-orbiting Challenger, Orbiter Vehicle (OV) 099. OV-099 was maneuvered to a 120-nautical-mile altitude and flown with open payload bay (PLB) in the velocity vector for the conducting of a test titled, 'Evaluation of Oxygen Interaction with Materials (EOIM)'. Atomic oxygen within the low orbital environment is known to be extremely reactive when in contact with solid surfaces. In the darkened area between the camera and the glowing OMS pods and vertical stabilizer are two trays of test materials.

  19. New directions and challenges for the O&M committee

    SciTech Connect

    Pelletier, J.P.

    1996-12-01

    In the second half of the decade of the nineties, the imperative of finding new ways to improve efficiency while maintaining safety is taking on a new urgency. The looming deregulation of the electric industry and the expected competition in the power production business fuels this urgency. The recently completed ASME research in the area of Risk-Based Inservice Testing offers the Operations and Maintenance (O&M) Committee an opportunity to meet this challenge. This opportunity, however, offers its own challenges. New ways of thinking about inservice testing and new technical skills will be needed to successfully incorporate this technology into Code documents. It will not be adequate to rely solely on incorporation of risk-based methods into the Code to meet this challenge. A thorough self assessment of what O&M does, how it is done, and the value added will help assure that the directions which are pursued do, indeed, meet the challenge ahead.

  20. Overall view of PLB and OMS / RCS engine thrusting

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Overall payload bay (PLB) view shows Inertial Upper Stage (IUS) Airborne Support Equipment (ASE) forward frame and aft frame tilt actuator (AFTA) table after IUS Tracking and Data Relay Satellite (TDRS) deploy. Vertical tail and Orbital Maneuvering System (OMS) pods with rear reaction control system (RCS) thruster firing (sidefiring) appears in background against blackness of space. Right right jet firing was photographed from more than 18 meters (60 feet) away in the cabin of the Earth-orbiting Challenger, Orbiter Vehicle (OV) 099.

  1. Overall view of PLB and OMS / RCS engine thrusting

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Overall payload bay (PLB) view shows Inertial Upper Stage (IUS) Airborne Support Equipment (ASE) forward frame and aft frame tilt actuator (AFTA) table after IUS Tracking and Data Relay Satellite (TDRS) deploy. Vertical tail and Orbital Maneuvering System (OMS) pods with rear reaction control system (RCS) thruster firing (upfiring) appears in background against blackness of space. Right up jet firing was photographed from more than 18 meters (60 feet) away by crewmembers on flight deck.

  2. EDITORIAL: Selected Papers from OMS'07, the 2nd Topical Meeting of the European Optical Society on Optical Microsystems (OMS)

    NASA Astrophysics Data System (ADS)

    Rendina, Ivo; Fazio, Eugenio; Ferraro, Pietro

    2008-06-01

    OMS'07 was the 2nd Topical Meeting of the European Optical Society (EOS) on Optical Microsystems (OMS). It was organized by the EOS in the frame of its international topical meeting activity, and after the success of the inaugural meeting was once again held in Italy, 30 September to 3 October 2007, amidst the wonderful scenery of the Island of Capri. The local organizing committee was composed of researchers from `La Sapienza' University in Rome and the National Council of Research (CNR) in Naples, Italy. A selected group of leading scientists in the field formed the international scientific committee. The conference was fully dedicated to the most recent advancements carried out in the field of optical microsystems. More then 150 scientists coming from five continents attended the conference and more than 100 papers were presented, organized into the following sessions: Photonic cystals and metamaterials Optofluidic microsystems and devices Optical microsystems and devices New characterization methods for materials and devices Application of optical systems Optical sources and photodetectors Optical resonators Nonlinear optic devices Micro-optical devices. Four keynote lecturers were invited for the Plenary sessions: Federico Capasso, Harvard University, USA; Bahram Javidi, University of Connecticut, USA (Distinguished Lecturer, Emeritus of LEOS--IEEE Society); Demetri Psaltis, EPFL, Lausanne, Switzerland; Ammon Yariv, California Institute of Technology, USA. Furthermore, 21 invited speakers opened each session of the conference with their talks. In addition a special session was organized to celebrate eighty years of the Isituto Nazionale di Ottica Applicata (INOA) of CNR. The special invited speaker for this session was Professor Theodor W Hänsch (Nobel Prize in Physics, 2005), who gave a lecture entitled `What can we do with optical frequency combs?' In this special issue of Journal of Optics A: Pure and Applied Optics, a selection of the most interesting

  3. Using collaborative work groups to reduce O&M costs

    SciTech Connect

    Francoeur, R.; Jones, J.N.

    1995-12-31

    Commonwealth Edison Company (ComEd) entered the nineties burdened with external distractions from its core business of power generation. Its unresolved 1987 rate case continued to face intervention in the courts. Some of its largest industrial and municipal customers were exploring more economical alternatives. The new convention facility in Chicago actually engaged an independent energy supplier. Retail wheeling was the hot topic, and internal problems were present. Operations and Maintenance (O&M) costs were steadily increasing. Two of their six nuclear stations were on the Nuclear Regulatory Commission`s Watch List. Immediate changes had to occur if ComEd was to ensure its future competitiveness. At ComEd Braidwood Nuclear Power Station some untraditional work methodologies were embarked upon to help the parent company reduce its O&M costs. Various types of collaborative work groups were formed, and have succeeded in lowering O&M costs through shorter refueling outages and the use of fewer contracted personnel. These collaborative work groups are listed below and are described in detail in the remainder of this paper: (1) A core group of Maintenance Modification Contractor (MMC) supervision integrated into the Owner`s Maintenance Staff, (2) A Corporate Outage Support Group of supervisory personnel which supplements the site`s Maintenance Staff, (3) The Integrated Outage and Turbine Overhaul Contractor using a mixture of its own and Maintenance Staff supervisory personnel during outages with the Owner supplementing craft support using a third-party, (4) Six nuclear stations sharing key MMC personnel to insure experienced individuals are used effectively, and (5) Composite teams of maintenance personnel working across defined disciplines Braidwood Station has capitalized on the strategy of positive collaboration to become one of the lowest cost producers of nuclear power. Its use has enabled the Station to successfully complete the last refueling outage in 40 days.

  4. Ultra-Wideband Optical Modulation Spectrometer (OMS) Development

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan (Technical Monitor); Tolls, Volker

    2004-01-01

    The optical modulation spectrometer (OMS) is a novel, highly efficient, low mass backend for heterodyne receiver systems. Current and future heterodyne receiver systems operating at frequencies up to a few THz require broadband spectrometer backends to achieve spectral resolutions of R approximately 10(exp 5) to 10(exp 6) to carry out many important astronomical investigations. Among these are observations of broad emission and absorption lines from extra-galactic objects at high redshifts, spectral line surveys, and observations of planetary atmospheres. Many of these lines are pressure or velocity broadened with either large half-widths or line wings extending over several GHz. Current backend systems can cover the needed bandwidth only by combining the output of several spectrometers, each with typically up to 1 GHz bandwidth, or by combining several frequency-shifted spectra taken with a single spectrometer. An ultra-wideband optical modulation spectrometer with 10 - 40 GHz bandwidth will enable broadband ob- servations without the limitations and disadvantages of hybrid spectrometers. Spectrometers like the OMS will be important for both ground-based observatories and future space missions like the Single Aperture Far-Infrared Telescope (SAFIR) which might carry IR/submm array heterodyne receiver systems requiring a spectrometer for each array pixel. Small size, low mass and small power consumption are extremely important for space missions. This report summarizes the specifications developed for the OMS and lists already identified commercial parts. The report starts with a review of the principle of operation, then describes the most important components and their specifications which were derived from theory, and finishes with a conclusion and outlook.

  5. Acides gras oméga-3 et dyslexie

    PubMed Central

    Zelcer, Michal; Goldman, Ran D.

    2015-01-01

    Résumé Question À la lumière de la hausse du nombre d’enfants d’âge scolaire ayant reçu un diagnostic de dyslexie, quel est le rôle des suppléments d’acides gras oméga-3 dans la prise en charge de cette affection? Réponse La dyslexie est le trouble d’apprentissage le plus répandu et elle est connue pour ses causes multifactorielles. De récentes données probantes pointent vers une corrélation entre le métabolisme défectueux des acides gras polyinsaturés et les troubles de neurodéveloppement, tels que la dyslexie. Bien que l’administration de suppléments d’acides gras oméga-3 aux enfants dyslexiques ait fait l’objet d’études, les données probantes sont limitées. Les critères diagnostiques homogènes de dyslexie, les mesures objectives de carence en acides gras et la surveillance étroite de l’apport alimentaire ne sont que quelques-uns des facteurs pouvant améliorer la qualité de la recherche dans ce domaine.

  6. AIDS-associated Kaposi's sarcoma (KS) cells express oncostatin M (OM)-specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor. Complete block of OM-induced KS cell growth and OM binding by anti-gp130 antibodies.

    PubMed Central

    Murakami-Mori, K; Taga, T; Kishimoto, T; Nakamura, S

    1995-01-01

    Oncostatin M (OM), which shares functional similarity and structural homology to leukemia inhibitory factor (LIF) and interleukin-6 (IL-6), functions as a potent growth factor for AIDS-associated Kaposi's sarcoma-derived cells (AIDS-KS cells). OM was also suggested to bind to the LIF receptor (LIF/OM receptor), which consists of a signal transducing subunit for LIF and IL-6 (gp130) and a LIF receptor alpha-subunit. Recent studies indicate that IL-6 has growth-stimulating activity for AIDS-KS cells. However, we find that AIDS-KS cell growth is exclusively induced by OM and not by LIF or IL-6. We also observed the lack of binding properties of AIDS-KS cells for LIF and IL-6. Scatchard plots revealed the existence of two affinity classes of OM receptor sites on AIDS-KS cells, with Kd values of 6-12 pM (high affinity) and 521-815 pM (low affinity). In competition binding studies, we find that the OM-specific receptor, but not the LIF/OM receptor, contributes to the OM-specific growth stimulation of AIDS-KS cells. We also noted that anti-gp130 antibodies can completely abolish OM-induced growth stimulation of AIDS-KS cells as well as OM binding to AIDS-KS cells. PCR amplification clearly revealed high levels of gp130 expression in AIDS-KS cells, while the transcript of LIF receptor alpha-subunit or IL-6 receptor alpha-subunit was not observed. Therefore, we conclude that (a) AIDS-KS cells express the OM-specific receptor with high and low affinity, but not the LIF/OM receptor; (b) gp130 on AIDS-KS cells plays a key role in OM binding and signaling on the OM-specific receptor; and (c) the lack of biological response of AIDS-KS cells to IL-6 and LIF can be explained by the absence of the IL-6 and LIF/OM receptors. All this evidence shows the correlation of OM-specific biological activity with expression of the OM-specific receptor and the involvement of gp130 on this receptor, as based on findings in in vitro growth assays and binding experiments for AIDS-KS cells. Images

  7. O&M Best Practices - A Guide to Achieving Operational Efficiency (Release 2.0)

    SciTech Connect

    Sullivan, Gregory P.; Pugh, Ray; Melendez, Aldo P.; Hunt, W. D.

    2004-07-31

    This guide, sponsored by DOE's Federal Energy Management Program, highlights operations and maintenance (O&M) programs targeting energy efficiency that are estimated to save 5% to 20% on energy bills without a significant capital investment. The purpose of this guide is to provide the federal O&M energy manager and practitioner with useful information about O&M management, technologies, energy efficiency and cost-reduction approaches.

  8. 20 CFR 229.68 - Reduction of DIB O/M.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Reduction of DIB O/M. 229.68 Section 229.68..., State, or Local Law or Plan § 229.68 Reduction of DIB O/M. A reduction for entitlement to worker's compensation or a public disability benefit is applied after the DIB O/M is reduced for age and the...

  9. 20 CFR 229.68 - Reduction of DIB O/M.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Reduction of DIB O/M. 229.68 Section 229.68..., State, or Local Law or Plan § 229.68 Reduction of DIB O/M. A reduction for entitlement to worker's compensation or a public disability benefit is applied after the DIB O/M is reduced for age and the...

  10. CSF neurofilament light chain is elevated in OMS (decreasing with immunotherapy) and other pediatric neuroinflammatory disorders.

    PubMed

    Pranzatelli, Michael R; Tate, Elizabeth D; McGee, Nathan R; Verhulst, Steven J

    2014-01-15

    Using a panel of seven brain cell-specific biomarkers in cerebrospinal fluid (CSF), pediatric opsoclonus-myoclonus syndrome (OMS) (n=234) was compared to pediatric non-inflammatory neurological controls (n=84) and other inflammatory neurological disorders (OIND) (n=44). Only CSF NFL was elevated in untreated OMS versus controls (+83%). It was 87% higher in OIND than in OMS. On combination treatment with front-loaded ACTH, IVIg, rituximab, median CSF NFL decreased by 60% to control levels. These biochemical data suggest neuronal/axonal injury in some children with OMS without indicators of astrogliosis, and reduction on sufficient immunotherapy. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. The OMS3 JGrass-NewAge Environmental Modelling System

    NASA Astrophysics Data System (ADS)

    Formetta, G.; David, O.; Rigon, R.

    2012-12-01

    The need for integrated analysis, and the multiplicity of possible goals in analyses that require hydro-biophysical modelling, necessitates more than ever the capability of composing modelling solutions with parts of known quality, which are transparent to users and consist of reusable model components. Moreover, modern hydrological modelling requires interaction with GIS tools to allow visualizations and the data-processing necessary to synthesise knowledge from high volumes of inputs and outputs data. Last but not least, doing science that is reproducible has requirements that go beyond the computational issues to embrace the possibility to inspection the tools, and easy compare modelling solutions by third party groups. The JGrass-NewAge system was born in order to satisfy these requirements. It is based on the geographic information system uDig-JGrass, and is composed of two parts: (i) the system of visualization of the data and of the results based on uDig; (ii) the modelling components. The latter are implemented as OMS3 components which can be connected or excluded at runtime, according to the needs and works seamlessly inside the uDig Spatial Toolbox. The system is based on a hillslope-link geometrical partition of the landscape, thus the basic unit, where the water budget is evaluated, is the hillslope, and each one of them drains into a single associated link rather than cells or pixels. To this conceptual partition corresponds an implementation of informatics that uses vectorial features for channels, and raster data for hillslopes. The mass budget for each hillslope can be performed in two ways: according to a modification of Duffy dynamical model of hillslope runoff or according to HyMod lumped model. Differently from traditional rainfall-runoff models where the discharge is usually given at the outlet of a catchment, the discharge is evaluated in each link of the river network according to a procedure presented in Cuencas model. The system includes

  12. Owner-controlled insurance programs: Reducing O&M costs

    SciTech Connect

    Charette, M.; Brady, N.

    1994-02-01

    The economic recession, increased competition from nonutility generators, and escalating Workers` Compensation costs are forcing electric utilities to reexamine how they finance the cost of risk. In addition to managed care programs, larger deductibles, and aggressive safety campaigns, utility risk and insurance executives are turning more than ever to Owner-Controlled Insurance Programs (OCIPs) to lower operation and maintenance (O&M) expenses. While electric utilities long have used OCIPs to control insurance costs during generating station and office building construction, this approach is now being employed for other projects. In the last few years, utilities have expanded the use of OCIPs to include scrubber installation, plant retrofit, and, more recently, for ongoing contract and maintenance work at operating fossil and nuclear plants. These OCIPs are also known as {open_quotes}gate{close_quotes} or {open_quotes}maintenance{close_quotes} wrap-ups.

  13. Variations in the OM/OC ratio of urban organic aerosol next to a major roadway.

    PubMed

    Brown, Steven G; Lee, Taehyoung; Roberts, Paul T; Collett, Jeffrey L

    2013-12-01

    Understanding the organic matter/organic carbon (OM/OC) ratio in ambient particulate matter (PM) is critical to achieve mass closure in routine PM measurements, to assess the sources of and the degree of chemical processing organic aerosol particles have undergone, and to relate ambient pollutant concentrations to health effects. Of particular interest is how the OM/OC ratio varies in the urban environment, where strong spatial and temporal gradients in source emissions are common. We provide results of near-roadway high-time-resolution PM1 OM concentration and OM/OC ratio observations during January 2008 at Fyfe Elementary School in Las Vegas, NV, 18 m from the U.S. 95 freeway soundwall, measured with an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-AMS). The average OM/OC ratio was 1.54 (+/- 0.20 standard deviation), typical of environments with a low amount of secondary aerosol formation. The 2-min average OM/OC ratios varied between 1.17 and 2.67, and daily average OM/OC ratios varied between 1.44 and 1.73. The ratios were highest during periods of low OM concentrations and generally low during periods of high OM concentrations. OM/OC ratios were low (1.52 +/- 0.14, on average) during the morning rush hour (average OM = 2.4 microg/m3), when vehicular emissions dominate this near-road measurement site. The ratios were slightly lower (1.46 +/- 0.10) in the evening (average OM = 6.3 microg/m3), when a combination of vehicular and fresh residential biomass burning emissions was typically present during times with temperature inversions. The hourly averaged OM/OC ratio peaked at 1.66 at midday. OM concentrations were similar regardless of whether the monitoring site was downwind or upwind of the adjacent freeway throughout the day, though they were higher during stagnant conditions (wind speed < 0.5 m/sec). The OM/OC ratio generally varied more with time of day than with wind direction and speed.

  14. Conduction de liquides aromatiques en géométrie pointe-plan

    NASA Astrophysics Data System (ADS)

    Brouche, M.; Gosse, J. P.; Gosse, B.

    1993-06-01

    The electrical conduction of purified aromatic liquids in the tip-plane electrode geometry was studied for high electric fields. The current voltage curves, the current pulses were measured for dc applied voltage in toluene, benzyltoluene, and in the saturated hydrocarbon n-decane. In n-decane, current pulses are similar to corona discharges in electronegative gases and to pulses previously studied in liquid cyclohexane. In aromatic liquids, a discontinuity in the current-voltage curve was also observed for an electric field of 4.5 ± 0.5 MV.cm^{-1} whereas current pulses were detected for higher fields. This behavior is attributed to the ionization and electronic attachment of aromatic molecules. On présente les résultats d'une étude du comportement de liquides aromatiques en champs électriques très élevés, dans la géométrie pointe-plan. Nous avons mesuré la conduction électrique en polarité négative de la pointe et les impulsions de courant en tension alternative, relatives à deux hydrocarbures aromatiques, le toluène et le benzyltoluène, et les avons comparées à ceux d'un hydrocarbure saturé, le n-décane. Dans le n-décane, à une tension seuil V_s, qui correspond à un champ seuil sur la pointe de 5 ± 1 MV.cm^{-1}, le courant est multiplié par un facteur 1 000 environ. Il est composé d'impulsions, détectées en tension alternative comme en tension continue, analogues aux impulsions de Trichel dans les gaz. Dans les liquides aromatiques, la discontinuité de courant est observée pour un champ seuil compris entre 4 et 5 MV.cm^{-1}. Par contre, les impulsions de courant ne sont détectées qu'à des tensions notablement supérieures à V_s. Ces impulsions sont aléatoires et ont une fréquence et une charge apparente inférieures à celles dans un hydrocarbure saturé. Ce comportement est attribué aux caractéristiques d'ionisation et d'attachement électronique des molécules aromatiques.

  15. 43 CFR 426.23 - Recovery of operation and maintenance (O&M) costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Recovery of operation and maintenance (O&M) costs. 426.23 Section 426.23 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.23 Recovery of operation and maintenance (O&M) costs. (a)...

  16. Facilitating Successful Outdoor O&M Instruction of Multihandicapped Blind Travelers.

    ERIC Educational Resources Information Center

    Ehresman, Paul

    1994-01-01

    An orientation and mobility (O&M) instructor presents a case study of a blind 14 year old with mild cognitive deficits and emotional and behavioral problems. The case study demonstrates the importance of individualizing the O&M curriculum, including changing the usual sequence of instruction. (DB)

  17. Facilitating Successful Outdoor O&M Instruction of Multihandicapped Blind Travelers.

    ERIC Educational Resources Information Center

    Ehresman, Paul

    1994-01-01

    An orientation and mobility (O&M) instructor presents a case study of a blind 14 year old with mild cognitive deficits and emotional and behavioral problems. The case study demonstrates the importance of individualizing the O&M curriculum, including changing the usual sequence of instruction. (DB)

  18. Glow experiment documentation of OMS/RCS pods and vertical stabilizer

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Glow experiment documentation of orbital maneuvering system (OMS) reaction control system (RCS) pods and vertical stabilizer shows chemoluminescent effect resulting from atomic oxygen impacting the spacecraft and building to the point that the atomic oxygen atoms combine to form molecules of oxygen. Image intensifier on NIKON 35mm camera used to record glow on vertical tail and OMS pods.

  19. Glow experiment documentation of OMS/RCS pods and vertical stabilizer

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Glow experiment documentation of orbital maneuvering system (OMS) reaction control system (RCS) pods and vertical stabilizer shows chemo-luminescent effect resulting from atomic oxygen impacting the spacecraft and building to the point that the atomic oxygen atoms combine to form molecules of oxygen. Image intensifier on NIKON 35mm camera was used to record glow on vertical tail and OMS pods.

  20. Providing O&M Services to Children and Youth with Severe Multiple Disabilities.

    ERIC Educational Resources Information Center

    Bailey, Brent R.; Head, Daniel N.

    1993-01-01

    This article argues that orientation and mobility (O&M) training should be part of functional and meaningful activities for children and youth with severe multiple disabilities including a visual impairment. Evidence is provided that out-of-context instruction has not been effective, and the role of the O&M instructor is discussed. (DB)

  1. Farming Systems Modeling Using the Object Modeling System (OMS): Overview, Applications, and Future Plans

    USDA-ARS?s Scientific Manuscript database

    Development of the Object Modeling System (OMS) modeling framework represents a comprehensive partnership between the USDA ARS/NRCS, USGS, and university collaborators. OMS helps streamline the development of integrated farming system models for current and future model delivery using a component-or...

  2. Potential of front-face fluorescence to monitor OM reduction in drinking water during potabilization process

    NASA Astrophysics Data System (ADS)

    Lacotte, Pierre

    2014-05-01

    Elimination of OM in drinking water represents a great challenge for municipalities and technical actors to ensure that it can be safely used for consumption purposes. Indeed, current indicators such as Total Organic Carbon (TOC), turbidity or UV-Absorbance at 254 nm (UVA254) enable only non-specific overview of the amount of organic residuals in water. Fluorescence EEMs are a potent tool for discrimination and deep analysis of OM detailed composition and behaviour. It has been shown that several forms of OM co-exist in raw water, and come from various origins (bacteria, humic compounds…). Potabilization operation is composed of different steps that aim at decreasing all forms of OM using chemical as well as physical methods (ozone oxidation, filtration on activated carbon or sand, flocculation etc.). Unfortunately, it has been observed that reduction of OM during this process was not identical for all the forms, and the process showed a particular lack of efficiency during raining periods. 130 samples of water at various stages of potabilization were analyzed using home-made compact fluorometer, an apparatus composed of UV excitation LEDs. Using chemometrical treatment of spectral data, we put into highlight 5 different forms of OM that were identified according to litterature data. We evidenced the critical steps of the purification on OM reduction, as well as the relative content of each form from raw to product water. In particular, we showed that two forms were less reduced than the other three, so that progressive enrichment of total OM in the former was observed throughout the process. Moreover, a study was carried out in order to establish calibration models over conventional analyses using the spectral information. Highly satisfying models were thus obtained over TOC, turbidity and UVA254, with average RMSEC values of 13%, 7% and 16% respectively. These results demonstrate the potential of the fluorescence analyzer to simultaneously predict three major

  3. OmZnT1 and OmFET, two metal transporters from the metal-tolerant strain Zn of the ericoid mycorrhizal fungus Oidiodendron maius, confer zinc tolerance in yeast.

    PubMed

    Khouja, Hassine Radhouane; Abbà, Simona; Lacercat-Didier, Laurence; Daghino, Stefania; Doillon, Didier; Richaud, Pierre; Martino, Elena; Vallino, Marta; Perotto, Silvia; Chalot, Michel; Blaudez, Damien

    2013-03-01

    Two full-length cDNAs (OmZnT1 and OmFET) encoding membrane transporters were identified by yeast functional screening in the heavy metal tolerant ericoid mycorrhizal isolate Oidiodendron maius Zn. OmZnT1 belongs to the Zn-Type subfamily of the cation diffusion facilitators, whereas OmFET belongs to the family of iron permeases. Their properties were investigated in yeast by functional complementation of mutants affected in metal uptake and metal tolerance. Heterologous expression of OmZnT1 and OmFET in a Zn-sensitive yeast mutant restored the wild-type phenotype. Additionally, OmZnT1 expression also restored cobalt tolerance in a Co-sensitive mutant. A GFP fusion protein revealed that OmZnT1 was targeted to the endoplasmic reticulum membrane, a result consistent with a function for OmZnT1 in metal sequestration. Similarly to other iron permeases, OmFET-GFP was localized on the plasma membrane. OmFET restored the growth of uptake-defective strains for iron and zinc. Zinc-sensitive yeast mutants expressing OmFET specifically accumulated magnesium, as compared to cells transformed with the empty vector. We suggest that OmFET may counteract zinc toxicity by increasing entry of magnesium into the cell.

  4. Increased prevalence of autoimmune disorders and autoantibodies in parents of children with opsoclonus-myoclonus syndrome (OMS).

    PubMed

    Krasenbrink, I; Fühlhuber, V; Juhasz-Boess, I; Stolz, E; Hahn, A; Kaps, M; Hero, B; Blaes, F

    2007-06-01

    Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disease in childhood which can be associated with neuroblastoma. Since autoantibodies have been detected in some patients with OMS, an autoimmune etiology is suspected. We compared the prevalence of autoimmune disorders and autoantibodies in parents of children with OMS and in a group of controls of same age and sex. Autoimmune diseases were found in 15.8% of the parents of OMS children, but only in 2.0% of the controls (p<0.001) There was also an increased prevalence of autoantibodies in the OMS parents (42.8% vs. 8.0%, p<0.001). Thyroid diseases were the most frequent autoimmune diseases found, followed by inflammatory rheumatic diseases. Interestingly, the OMS parents also had significantly more autoantibodies against CNS structures than the controls (p<0.01). These findings support the autoimmune hypothesis of childhood OMS and may also hint to a genetic susceptibility for OMS.

  5. Graphitic carbon nitride induced activity enhancement of OMS-2 catalyst for pollutants degradation with peroxymonosulfate

    NASA Astrophysics Data System (ADS)

    Li, Jun; Fang, Jia; Gao, Long; Zhang, Jingwen; Ruan, Xinchao; Xu, Aihua; Li, Xiaoxia

    2017-04-01

    Low valent manganese species and surface oxygen vacancies in OMS-2 play an important role in catalytic reactions, and it is highly desirable and challenging to develop a feasible strategy of increasing the Mn(II) and Mn(III) species concentration in the oxide. Herein, the OMS-2/g-C3N4 hybrids (OMS-2/CN) were prepared by a facile refluxing approach. It was found that the MnOx precursor from the reaction of KMnO4 and MnSO4 was transformed into OMS-2 nanofibers with the formation of more Mn(II) and Mn(III) species in OMS-2 and the destruction and oxidation of g-C3N4. The hybrids exhibited higher efficiency for pollutants degradation in the presence of PMS than the pure OMS-2 or g-C3N4. There was a linear correlation between the specific initial rate and the ratio of Mn(II + III)/Mn(IV). Mechanism investigation indicated that high active manganese species or caged radicals were produced through the oxidation of Mn(II) and Mn(III) by PMS and contributed to the degradation reaction. During five consecutive cycles, the catalyst exhibited good reusability and stability. Therefore, the OMS-2/CN hybrids are promising catalysts for wastewater treatment with PMS as the oxidant.

  6. Cytokines, cytokine antagonists, and soluble adhesion molecules in pediatric OMS and other neuroinflammatory disorders.

    PubMed

    Pranzatelli, Michael R; Tate, Elizabeth D; McGee, Nathan R; Colliver, Jerry A

    2013-03-15

    To test for hypothesized disease- and treatment-induced changes in cytokines and adhesion molecules in children with opsoclonus-myoclonus syndrome (OMS). Multiplex bead assay technology was used for simultaneous measurement of 34 soluble cytokines in cerebrospinal fluid (CSF) and serum. Soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were measured by ELISA. In total, there were 388 children (239 OMS, 114 controls, and 35 other inflammatory neurological disorders (OIND)). In untreated OMS, mean CSF IL-6 was elevated 2.3-fold, but 67-fold in OIND, without significant differences in other CSF cytokines. Mean serum concentrations of sIL-2Ra (+50%) and CXCL1 (+70%) (p<0.0001) were also raised. CSF CCL5 was more often detected in untreated OMS than controls (p=0.005), as was serum CCL11 and IL-13 in treated OMS. Mean CSF CCL4 and IL-1Ra were selectively higher in IVIg-treated OMS (p≤0.0001). CSF sICAM-1 was elevated only in OIND (3.3-fold); serum sICAM-1 was higher in untreated OMS (+21%); and sVCAM-1 was not affected. No correlations with OMS severity or duration were identified. Novel cytokine, cytokine antagonist, and soluble adhesion molecule abnormalities due to OMS or treatment were found. However, the normality of much of the data strengthens previous findings implicating B cell mechanisms. Copyright © 2013 Elsevier B.V. All rights reserved.

  7. Spectroscopic Investigation of O-,M-, and P-Cyanostyrenes

    NASA Astrophysics Data System (ADS)

    Korn, Joseph A.; Knezz, Stephanie N.; McMahon, Robert J.; Zwier, Timothy S.

    2014-06-01

    The atmosphere of Titan contains nitrogen, methane, and a rich mixture of more complex hydrocarbons and nitriles produced by photochemical processing. Data from the 2005 Cassini-Huygens mission suggests that among the more complex compounds are substituted benzenes that are themselves precursors to large polymeric tholins. Nitriles are particularly prevalent in Titan's atmosphere due to the dominance of N2 in the atmosphere. The cyanostyrenes are of particular interest, in part because they have the same molecular formula (C9H7N) as quinoline, a prototypical heteroaromatic, and therefore could engage in photochemical isomerization to form this molecule of significant pre-biotic relevance. As a first step in understanding the pathways leading to heteroaromatics, we have studied the isotope-selective spectroscopy of o-,m-, and p-cyanostyrene under jet-cooled conditions relevant to Titan's atmosphere. In this talk, the excitation and emission spectra for the three isomers will be presented. Using a combination of resonant two-photon ionization, LIF excitation, and dispersed fluorescence spectroscopies, the vibronic spectroscopy of the three isomers were recorded and compared. The meta isomer has two conformational isomers, which have been distinguished and studied using hole-burning methods. The talk will compare and contrast the UV spectral signatures of the set of structural and conformational isomers of the cyanostyrenes, using the ethynylstyrene counterparts as points of comparison. Sebree, J. A.; Kidwell, N. M.; Selby, T. M.; Amberger, B. K.; McMahon, R. J.; Zwier, T. S., Photochemistry of Benzylallene: Ring-Closing Reactions to Form Naphthalene. Journal of the American Chemical Society 2012, 134 (2), 1153-1163. Selby, T. M.; Clarkson, J. R.; Mitchell, D.; Fitzpatrick, J. A. J.; Lee, H. D.; Pratt, D. W.; Zwier, T. S., Isomer-Specific Spectroscopy and Conformational Isomerization Energetics of o-, m-, and p-Ethynylstyrenes. The Journal of Physical Chemistry A 2005

  8. Wood source and pyrolysis temperature interact to control PyOM degradation rates

    NASA Astrophysics Data System (ADS)

    Bird, J. A.; Hatton, P. J.; Filley, T. R.; Chatterjee, S.; Auclerc, A.; Gormley, M.; Dastmalchi, K.; Stark, R. E.; Nadelhoffer, K. J.

    2015-12-01

    Surprisingly little is known about how shifts in tree species composition and increased forest fire frequency and intensity will affect one of the most stable pools of soil organic matter, i.e. the pyrogenic organic matter (PyOM or char). In a previous study, we showed that wood source and pyrolysis temperature interact to control PyOM structure and potential reactivity for two tree species common in high-latitude forests, jack pine (JP) and red maple (RM). Here, we investigate whether these differences affect PyOM turnover by examining the fates of 13C/15N-enriched JP wood and PyOM pyrolyzed at 300 (JP300) and 450 °C (JP450) and RM pyrolyzed at 450 °C (RM450). The substrates were applied 1-3 cm below the O/A interface of a well-drained Spodosol in a long-term forest fire study located at the University of Michigan Biological Station (Pellston, MI, USA). 13C-CO2effluxes from the first 996 days of decay showed a significant wood source by pyrolysis temperature interaction on PyOM field mineralisation rates, with RM450 mineralising twice faster than JP450 during the first 90 days. Increasing pyrolysis temperature substantially decreased field mineralization rates during the first 996 days, with mineralisation rates 24 and 80 times slower for JP300 and JP450 compared with JP wood. After 1 year, (i) bacterial groups were large sinks for PyOM-derived C as pyrolysis temperature increased and as substrate use efficiency decreased; (ii) potential phenol oxidase and net peroxidase activities were unaffected by the PyOM addition, although net peroxidase activities measured tended to lesser for soils amended with JP450 and RM450; and (iii) Collembola detritivores appeared less likely to be found for soils amended with JP450 and RM450. PyOM-derived C and N recoveries did not differ after 1 year; we will present 3-y recovery data. Our results suggest that the composition of angiosperms (e.g. RM) and gymnosperms (e.g. JP) in high-latitude forests is an underappreciated but

  9. Investigations on three and two coefficient Cauchy model for refractive indices of 5O.m and 6O.m liquid crystals

    NASA Astrophysics Data System (ADS)

    Raja Shekar, P. V.; Madhavi Latha, D.; Pisipati, V. G. K. M.

    2017-02-01

    The refractive indices of six members of N-(p-n-pentyloxy benzylidene)-p-n-alkyl anilines (5O.m), with m = 1, 2, 5, 6, 8 and 10 and two members of N-(p-n-hexyloxy benzylidene)-p-n-alkyl anilines (6O.m), with m = 2 and 4 LC compounds were measured with the help of modified spectrometer at four different wavelengths. The experimental data of wavelength dependent refractive indices is fitted using three and two coefficient Cauchy model. The applicability of these two models is assessed based on the fitting parameters as well as from the measured birefringence of liquid crystals.

  10. Mathematik in der Drahtlosen Kommunikation

    NASA Astrophysics Data System (ADS)

    Boche, Holger; Eisenblätter, Andreas

    Die Mobilkommunikation besitzt heute große wirtschaftliche Bedeutung. Sie hat seit der Einführung des derzeit noch dominierenden Mobilfunkstandards GSM Anfang der neunziger Jahre einen enormen Einfluss auf das gesellschaftliche Leben genommen. Mit neuen Anwendungsfeldern, z. B. im Maschinen- und Anlagenbau, in der Automobilindustrie und im Wohnbereich, wird die Bedeutung der Mobilkommunikation weiter steigen. Um der Vielfalt der Anwendungen gerecht zu werden und die Wünsche nach neuen Diensten erfüllen zu können, werden fortwährend neue Mobilfunksysteme eingeführt.

  11. Setting up an Asbestos Operations and Maintenance (O&M) Program

    EPA Pesticide Factsheets

    Covers steps a buidling's O&M plan should including: appointing an asbestos program manager, inspecting the building, developing a plan, and if necessary selecting and implementing larger repair or abatement projects.

  12. A Best Practice for Developing Availability Guarantee Language in Photovoltaic (PV) O&M Agreements.

    SciTech Connect

    Klise, Geoffrey Taylor; Balfour, John

    2015-11-01

    This document outlines the foundation for developing language that can be utilized in an Equipment Availability Guarantee, typically included in an O&M services agreement between a PV system or plant owner and an O&M services provider, or operator. Many of the current PV O&M service agreement Availability Guarantees are based on contracts used for traditional power generation, which create challenges for owners and operators due to the variable nature of grid-tied photovoltaic generating technologies. This report documents language used in early PV availability guarantees and presents best practices and equations that can be used to more openly communicate how the reliability of the PV system and plant equipment can be expressed in an availability guarantee. This work will improve the bankability of PV systems by providing greater transparency into the equipment reliability state to all parties involved in an O&M services contract.

  13. Argyrophilic nucleolar organizer regions (AgNORs) in odontogenic myxoma (OM) and ameloblastic fibroma (AF).

    PubMed

    Martins, C; Carvalho, Y R; do Carmo, M A

    2001-09-01

    Ten cases of odontogenic myxoma (OM) and six cases of ameloblastic fibroma (AF) were subjected to comparative analysis by the AgNOR technique, in order to determine a possible difference in cell proliferation index between these lesions. The mean AgNOR number of the mesenchymal component of AF was compared with its epithelial component and the difference was not found to be statistically significant. The mean AgNOR index of the AF group was significantly higher than that of the OM group. Moreover, the mesenchymal component of AF demonstrated increased AgNOR numbers compared with that of OM (P<0.05). These results suggest that the epithelial and mesenchymal components of AF may have similar cell proliferative activity. However, the cell proliferative index of this lesion seems to be higher than that of OM.

  14. The effect of Ce ion substituted OMS-2 nanostructure in catalytic activity for benzene oxidation

    NASA Astrophysics Data System (ADS)

    Hou, Jingtao; Li, Yuanzhi; Mao, Mingyang; Zhao, Xiujian; Yue, Yuanzheng

    2014-11-01

    The nanostructure of Ce doped OMS-2 plays a very important role in its catalytic property. We demonstrate by density functional theory (DFT) calculations that the unique nanostructure of the Ce ion substituted OMS-2 with Mn vacancy in the framework is beneficial for the improvement of catalytic activity, while the nanostructure of the Ce ion substituted OMS-2 without defects are detrimental to the catalytic activity. We establish a novel and facile strategy of synthesizing these unique Ce ion substituted OMS-2 nanostructure with Mn vacancies in the framework by hydrothermal redox reaction between Ce(NO3)3 and KMnO4 with KMnO4/Ce(NO3)3 at a molar ratio of 3 : 1 at 120 °C. Compared to pure OMS-2, the produced catalyst of Ce ion substituted OMS-2 ultrathin nanorods exhibits an enormous enhancement in the catalytic activity for benzene oxidation, which is evidenced by a significant decrease (ΔT50 = 100 °C, ΔT90 = 129 °C) in the reaction temperature of T50 and T90 (corresponding to the benzene conversion = 50% and 90%), which is considerably more efficient than the expensive supported noble metal catalyst (Pt/Al2O3). We combine both theoretical and experimental evidence to provide a new physical insight into the significant effect due to the defects induced by the Ce ion substitution on the catalytic activity of OMS-2. The formation of unique Ce ion substituted OMS-2 nanostructure with Mn vacancies in the framework leads to a significant enhancement of the lattice oxygen activity, thus tremendously increasing the catalytic activity.The nanostructure of Ce doped OMS-2 plays a very important role in its catalytic property. We demonstrate by density functional theory (DFT) calculations that the unique nanostructure of the Ce ion substituted OMS-2 with Mn vacancy in the framework is beneficial for the improvement of catalytic activity, while the nanostructure of the Ce ion substituted OMS-2 without defects are detrimental to the catalytic activity. We establish a novel

  15. Elements of an Asbestos Operations and Maintenance (O&M) Program

    EPA Pesticide Factsheets

    Links to descriptions of Elements of an Operations and Maintenance (O&M) Program: Training, Occupant Notification, Monitoring ACM, Job-Site Controls for Work Involving ACM, Safe Work Practices, Recordkeeping, Worker Protection.

  16. Synthesis of single crystal manganese oxide octahedral molecular sieve (OMS) nanostructures with tunable tunnels and shapes.

    PubMed

    Li, Wei-Na; Yuan, Jikang; Gomez-Mower, Sinue; Sithambaram, Shantakumar; Suib, Steven L

    2006-02-23

    A new and facile route is reported to manipulate the self-assembly synthesis of hierarchically ordered Rb-OMS-2 and pyrolusite with an interesting flowerlike morphology by a direct and mild reaction between rubidium chromateand manganese sulfate without any organic templates. The crystal forms, morphologies, and tunnel sizes of the obtained OMS materials can be controlled. A mechanism for the growth of manganese dioxides with flowerlike architectures was proposed. The obtained products exhibit potential for use in catalysis and other applications.

  17. STS-26 Discovery, Orbiter Vehicle (OV) 103, OMS pod leak repair at KSC

    NASA Technical Reports Server (NTRS)

    1988-01-01

    At the Kennedy Space Center (KSC), Rockwell manufacturing engineering specialist Claude Willis (left) and Rockwell manufacturing supervisor George Gallagher begin installation of a 'clamshell' device in the left orbital maneuvering system (OMS) pod reaction control system (RCS) of Discovery, Orbiter Vehicle (OV) 103. Gallagher performed the OMS pod nitric acid oxidizer leak repair operation using the two newly cut access ports in the Orbiter's aft bulkhead.

  18. The effect of Ce ion substituted OMS-2 nanostructure in catalytic activity for benzene oxidation.

    PubMed

    Hou, Jingtao; Li, Yuanzhi; Mao, Mingyang; Zhao, Xiujian; Yue, Yuanzheng

    2014-12-21

    The nanostructure of Ce doped OMS-2 plays a very important role in its catalytic property. We demonstrate by density functional theory (DFT) calculations that the unique nanostructure of the Ce ion substituted OMS-2 with Mn vacancy in the framework is beneficial for the improvement of catalytic activity, while the nanostructure of the Ce ion substituted OMS-2 without defects are detrimental to the catalytic activity. We establish a novel and facile strategy of synthesizing these unique Ce ion substituted OMS-2 nanostructure with Mn vacancies in the framework by hydrothermal redox reaction between Ce(NO3)3 and KMnO4 with KMnO4/Ce(NO3)3 at a molar ratio of 3 : 1 at 120 °C. Compared to pure OMS-2, the produced catalyst of Ce ion substituted OMS-2 ultrathin nanorods exhibits an enormous enhancement in the catalytic activity for benzene oxidation, which is evidenced by a significant decrease (ΔT(50) = 100 °C, ΔT(90) = 129 °C) in the reaction temperature of T50 and T90 (corresponding to the benzene conversion = 50% and 90%), which is considerably more efficient than the expensive supported noble metal catalyst (Pt/Al2O3). We combine both theoretical and experimental evidence to provide a new physical insight into the significant effect due to the defects induced by the Ce ion substitution on the catalytic activity of OMS-2. The formation of unique Ce ion substituted OMS-2 nanostructure with Mn vacancies in the framework leads to a significant enhancement of the lattice oxygen activity, thus tremendously increasing the catalytic activity.

  19. The Cost of Culture: Controlling DOD’s Runaway O&M Spending

    DTIC Science & Technology

    2013-01-01

    operating at steady- state, in a war, or absorbing a postconflict drawdown. Potential solutions for each case are presented herein. Background O&M... postconflict drawdowns. Use It or Lose It: Steady- state o&M Growth Upon entering the main gate of nearly any operational Air Force base, one of the first...for which DOD plans are fully specified. Key: a. For 2002 to 2013, supplemental and emergency funding for overseas contingency operations, such as

  20. OM-85 is an immunomodulator of interferon-β production and inflammasome activity

    PubMed Central

    Dang, A. T.; Pasquali, C.; Ludigs, K.; Guarda, G.

    2017-01-01

    The inflammasome–IL-1 axis and type I interferons (IFNs) have been shown to exert protective effects upon respiratory tract infections. Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive pulmonary disease (COPD). OM-85 is a bacterial extract with proved efficacy against COPD and recurrent respiratory tract infections, a cause of co-morbidity in asthmatic patients. We therefore asked whether OM-85 affects the above-mentioned innate immune pathways. Here we show that OM-85 induced interferon-β through the Toll-like receptor adaptors Trif and MyD88 in bone marrow-derived dendritic cells. Moreover, it exerted a dual role on IL-1 production; on the one hand, it upregulated proIL-1β and proIL-1α levels in a MyD88-dependent manner without activating the inflammasome. On the other hand, it repressed IL-1β secretion induced by alum, a well-known NLRP3 activator. In vivo, OM-85 diminished the recruitment of inflammatory cells in response to peritoneal alum challenge. Our findings therefore suggest that OM-85 favors a protective primed state, while dampening inflammasome activation in specific conditions. Taken together, these data bring new insights into the mechanisms of OM-85 action on innate immune pathways and suggest potential explanations for its efficacy in the treatment of virus-induced airway diseases. PMID:28262817

  1. OM-85 is an immunomodulator of interferon-β production and inflammasome activity.

    PubMed

    Dang, A T; Pasquali, C; Ludigs, K; Guarda, G

    2017-03-06

    The inflammasome-IL-1 axis and type I interferons (IFNs) have been shown to exert protective effects upon respiratory tract infections. Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive pulmonary disease (COPD). OM-85 is a bacterial extract with proved efficacy against COPD and recurrent respiratory tract infections, a cause of co-morbidity in asthmatic patients. We therefore asked whether OM-85 affects the above-mentioned innate immune pathways. Here we show that OM-85 induced interferon-β through the Toll-like receptor adaptors Trif and MyD88 in bone marrow-derived dendritic cells. Moreover, it exerted a dual role on IL-1 production; on the one hand, it upregulated proIL-1β and proIL-1α levels in a MyD88-dependent manner without activating the inflammasome. On the other hand, it repressed IL-1β secretion induced by alum, a well-known NLRP3 activator. In vivo, OM-85 diminished the recruitment of inflammatory cells in response to peritoneal alum challenge. Our findings therefore suggest that OM-85 favors a protective primed state, while dampening inflammasome activation in specific conditions. Taken together, these data bring new insights into the mechanisms of OM-85 action on innate immune pathways and suggest potential explanations for its efficacy in the treatment of virus-induced airway diseases.

  2. Contribution of effluent organic matter (EfOM) to ultrafiltration (UF) membrane fouling: isolation, characterization, and fouling effect of EfOM fractions.

    PubMed

    Zheng, Xing; Khan, Muhammad Tariq; Croué, Jean-Philippe

    2014-11-15

    EfOM has been regarded as a major organic foulant resulting in UF membrane fouling in wastewater reclamation. To investigate fouling potential of different EfOM fractions, the present study isolated EfOM into hydrophobic neutrals (HPO-N), colloids, hydrophobic acids (HPO-A), transphilic neutrals and acids (TPI), and hydrophilics (HPI), and tested their fouling effect in both salt solution and pure water during ultrafiltration (UF). Major functional groups and chemical structure of the isolates were identified using Fourier transform infrared spectroscopy (FT-IR) and solid-state carbon nuclear magnetic resonance ((13)C NMR) analysis. The influence of the isolation process on the properties of EfOM fractions was minor because the raw and reconstituted secondary effluents were found similar with respect to UV absorbance, molecular size distribution, and fluorescence character. In membrane filtration tests, unified membrane fouling index (UMFI) and hydraulic resistance were used to quantify irreversible fouling potential of different water samples. Results show that under similar DOC level in feed water, colloids present much more irreversible fouling than other fractions. The fouling effect of the isolates is related to their size, chemical properties, and solution chemistry. Further investigations have identified that the interaction between colloids and other fractions also influences the performance of colloids in fouling phenomena. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Remarkable promotion effect of trace sulfation on OMS-2 nanorod catalysts for the catalytic combustion of ethanol.

    PubMed

    Zhang, Jie; Zhang, Changbin; He, Hong

    2015-09-01

    OMS-2 nanorod catalysts were synthesized by a hydrothermal redox reaction method using MnSO4 (OMS-2-SO4) and Mn(CH3COO)2 (OMS-2-AC) as precursors. SO4(2-)-doped OMS-2-AC catalysts with different SO4(2-) concentrations were prepared next by adding (NH4)2SO4 solution into OMS-2-AC samples to investigate the effect of the anion SO4(2-) on the OMS-2-AC catalyst. All catalysts were then tested for the catalytic oxidation of ethanol. The OMS-2-SO4 catalyst synthesized demonstrated much better activity than OMS-2-AC. The SO4(2-) doping greatly influenced the activity of the OMS-2-AC catalyst, with a dramatic promotion of activity for suitable concentration of SO4(2-) (SO4/catalyst=0.5% W/W). The samples were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), inductively coupled plasma optical emission spectroscopy (ICP-OES), NH3-TPD and H2-TPR techniques. The results showed that the presence of a suitable amount of SO4(2-) species in the OMS-2-AC catalyst could decrease the Mn-O bond strength and also enhance the lattice oxygen and acid site concentrations, which then effectively promoted the catalytic activity of OMS-2-AC toward ethanol oxidation. Thus it was confirmed that the better catalytic performance of OMS-2-SO4 compared to OMS-2-AC is due to the presence of some residual SO4(2-) species in OMS-2-SO4 samples. Copyright © 2015. Published by Elsevier B.V.

  4. BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.

    PubMed

    Pranzatelli, Michael R; Tate, Elizabeth D; McGee, Nathan R; Travelstead, Anna L; Colliver, Jerry A; Ness, Jayne M; Ransohoff, Richard M

    2013-01-16

    B-cell dysregulation has been implicated but not fully characterized in pediatric opsoclonus-myoclonus syndrome (OMS), a neuroblastoma-associated neuroinflammatory disorder. To assess the role of B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), two critical B cell-modulating cytokines, as potential biomarkers of disease activity and treatment biomarkers in OMS. Soluble BAFF and APRIL were measured in cerebrospinal fluid (CSF) and serum by ELISA in 433 children (296 OMS, 109 controls, 28 other inflammatory neurological disorders (OIND)). BAFF-R receptors on circulating CD19+ B cells were measured by flow cytometry. A blinded scorer rated motor severity on the OMS Evaluation Scale. Immunotherapies were evaluated cross-sectionally and longitudinally. The mean CSF BAFF concentration, which was elevated in untreated OMS and OIND, correlated with OMS severity category (P = 0.006), and reduction by adrenocorticotropic hormone or corticotropin (ACTH) (-61%) or corticosteroids (-38%) was seen at each level of severity. In contrast, CSF APRIL was normal in OMS and OIND and unaffected by immunotherapy. When the entire OMS dataset was dichotomized into 'high' versus 'normal' CSF BAFF concentration, the phenotype of the high group included greater motor severity and number of CSF oligoclonal bands, and a higher concentration of inflammatory chemokines CXCL13 and CXCL10 in CSF and CXCL9 and CCL21 in serum. Serum APRIL was 6.7-fold higher in the intravenous immunoglobulins (IVIg) group, whereas serum BAFF was 2.6-fold higher in the rituximab group. The frequency of B cell BAFF-R expression was similar in untreated and treated OMS. Longitudinal studies of CSF BAFF revealed a significant decline in ACTH-treated patients (with or without rituximab) (P < 0.0001). Longitudinal studies of serum APRIL showed a 2.9-fold increase after 1 to 2 g/kg IVIg monotherapy (P = 0.0003). Striking distinctions in BAFF/APRIL signaling were found. OMS displayed

  5. BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy

    PubMed Central

    2013-01-01

    Background B-cell dysregulation has been implicated but not fully characterized in pediatric opsoclonus-myoclonus syndrome (OMS), a neuroblastoma-associated neuroinflammatory disorder. Objective To assess the role of B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), two critical B cell-modulating cytokines, as potential biomarkers of disease activity and treatment biomarkers in OMS. Methods Soluble BAFF and APRIL were measured in cerebrospinal fluid (CSF) and serum by ELISA in 433 children (296 OMS, 109 controls, 28 other inflammatory neurological disorders (OIND)). BAFF-R receptors on circulating CD19+ B cells were measured by flow cytometry. A blinded scorer rated motor severity on the OMS Evaluation Scale. Immunotherapies were evaluated cross-sectionally and longitudinally. Results The mean CSF BAFF concentration, which was elevated in untreated OMS and OIND, correlated with OMS severity category (P = 0.006), and reduction by adrenocorticotropic hormone or corticotropin (ACTH) (−61%) or corticosteroids (−38%) was seen at each level of severity. In contrast, CSF APRIL was normal in OMS and OIND and unaffected by immunotherapy. When the entire OMS dataset was dichotomized into ‘high’ versus ‘normal’ CSF BAFF concentration, the phenotype of the high group included greater motor severity and number of CSF oligoclonal bands, and a higher concentration of inflammatory chemokines CXCL13 and CXCL10 in CSF and CXCL9 and CCL21 in serum. Serum APRIL was 6.7-fold higher in the intravenous immunoglobulins (IVIg) group, whereas serum BAFF was 2.6-fold higher in the rituximab group. The frequency of B cell BAFF-R expression was similar in untreated and treated OMS. Longitudinal studies of CSF BAFF revealed a significant decline in ACTH-treated patients (with or without rituximab) (P < 0.0001). Longitudinal studies of serum APRIL showed a 2.9-fold increase after 1 to 2 g/kg IVIg monotherapy (P = 0.0003). Conclusions Striking distinctions

  6. Droplet infiltration and OM composition of intact soil structural surfaces for studying mass exchange

    NASA Astrophysics Data System (ADS)

    Leue, Martin, ,, Dr.; Gerke, PD Horst H., ,, Dr.; Godow, Sophie Ch.; Ellerbrock, PD Ruth H., ,, Dr.

    2014-05-01

    During rapid percolation through macropores with local nonequilibrium conditions water and solute mass exchange with the porous matrix and sorption of reactive components is both taken place at the surface of preferential flow paths. Aggregate surfaces can be coated by illuviated clayey particles and biopores covered by plant residues or earthworm casts. By controlling wettability and sorption properties, the organic matter (OM) of surface coatings may also affect the transport properties of structured soils. Composition of OM in wall coatings was found spatially distributed at the mm-scale; thus, it remained unclear if water absorption by the soil matrix (i.e., mass exchange) was affected by locally-distributed OM. For samples with intact aggregate surfaces and biopore walls taken at clay-illuvial subsoil horizon of Luvisols developed from Loess and glacial till, the mm-scale spatial distribution of OM composition was measured using diffuse reflectance infrared spectroscopy (DRIFT). Spectra were analysed with respect to alkyl and carboxyl functional groups in OM to obtain an estimate for its potential wettability. The infiltration dynamic of water droplets was evaluated using contact angle measurements and droplet penetration time. The potential wettability of OM differed for coatings and burrow walls and was generally lower for the Loess-derived than for the till-derived samples. The droplet infiltration times were significantly lower only for the Loess Luvisol samples. The results suggest that mass exchange between flow path and matrix can be affected by OM composition of structural surfaces among other factors such as texture, moisture, and chemical status (pH).

  7. Impact of EfOM size on competition in activated carbon adsorption of organic micro-pollutants from treated wastewater.

    PubMed

    Zietzschmann, Frederik; Worch, Eckhard; Altmann, Johannes; Ruhl, Aki Sebastian; Sperlich, Alexander; Meinel, Felix; Jekel, Martin

    2014-11-15

    The competitive impacts of different fractions of wastewater treatment plant effluent organic matter (EfOM) on organic micro-pollutant (OMP) adsorption were investigated. The fractionation was accomplished using separation by nanofiltration (NF). The waters resulting from NF were additionally treated to obtain the same dissolved organic carbon (DOC) concentrations as the initial water. Using size exclusion chromatography (LC-OCD) it could be shown that the NF treatment resulted in an EfOM separation by size. Adsorption tests showed different competitive effects of the EfOM fractions with the OMP. While large EfOM compounds that were retained in NF demonstrated a reduced competition as compared to the raw water, the NF-permeating EfOM compounds showed an increased competition with the majority of the measured OMP. The effects of small size EfOM are particularly negative for OMP which are weak/moderate adsorbates. Adsorption analysis was carried out for the differently fractionized waters. The small sized EfOM contain better adsorbable compounds than the raw water while the large EfOM are less adsorbable. This explains the observed differences in the EfOM competitiveness. The equivalent background compound (EBC) model was applied to model competitive adsorption between OMP and EfOM and showed that the negative impacts of EfOM on OMP adsorption increase with decreasing size of the EfOM fractions. The results suggest that direct competition for adsorption sites on the internal surface of the activated carbon is more substantial than indirect competition due to pore access restriction by blockage. Another explication for reduced competition by large EfOM compounds could be the inability to enter and block the pores due to size exclusion.

  8. Temperature & wood source control PyOM turnover in a Northern American forest

    NASA Astrophysics Data System (ADS)

    Hatton, Pierre-Joseph; Le Moine, James; Auclerc, Apolline; Gormley, Mark; Filley, Tim R.; Nadelhoffer, Knute J.; Bird, Jeff. A.

    2016-04-01

    Surprisingly little is known about how pyrolysis temperature and wood source affect the stability of forest-fire derived pyrogenic organic matter (PyOM). Here, we show that wood source and temperature affect in situ mineralization rates of PyOM in soils for two co-occurring gymnosperm (jack pine; JP [Pinus banksiana]) and angiosperm (red maple; RM [Acer rubrum])¬ species from North American boreal-temperate ecotones. We assess the effect of pyrolysis temperature on PyOM fates by following the decay of 13C/15N-enriched JP wood (JPwood) and PyOM produced at 300 °C (JP300) and 450 °C (JP450); and assess the effect of PyOM wood source by comparing fates of JP450 and RM450. JPwood mineralized 18× faster than JP300 and 44× faster than JP450 after 2.8y. RM450 mineralized initially faster than JP450 during the first ~2y, but became equivalent afterwards (1.1±0.2% of CO¬2 losses after 2.8y). Modeled turnover times suggest that this can be attributed to ~1% of fast-cycling PyOM (<3y). Slower-cycling pools are 12× faster for JPwood (13±5y) than for JP300 (157±28y) and 55× faster than for JP450 (700±229y). Modeled turnover times of the slow-cycling pools were equivalent for JP450 and RM450. The priming effect was positive for JPwood (0.10±0.05), neutral for JP300 (-0.02±0.04), and negative for JP450 (-0.15±0.03) and RM50 (-0.59±0.03). DOC losses were minimal compared with CO2 losses (DOC:CO2 ratio ≤0.005), but followed the same patterns: JPwood 6× greater than that of JP300 and 39× greater compared with JP450. After 1y, C recoveries were lower for JPwood than for PyOM, with no influence of pyrolysis temperature or wood source (yet); N recoveries did not differ. PLFA-(13)C data reveal that (i) treatments have similar microbial communities after 1y, (ii) JPwood is preferentially utilized by fungi, and (iii) bacteria increasingly utilize PyOM as pyrolysis temperature increases. Estimated carbon use efficiency decreased with increasing pyrolysis temperature

  9. Significant issues and changes for ANSI/ASME OM-1 1981, part 1, ASME OMc code-1994, and ASME OM Code-1995, Appendix I, inservice testing of pressure relief devices in light water reactor power plants

    SciTech Connect

    Seniuk, P.J.

    1996-12-01

    This paper identifies significant changes to the ANSI/ASME OM-1 1981, Part 1, and ASME Omc Code-1994 and ASME OM Code-1995, Appendix I, {open_quotes}Inservice Testing of Pressure Relief Devices in Light-Water Reactor Power Plants{close_quotes}. The paper describes changes to different Code editions and presents insights into the direction of the code committee and selected topics to be considered by the ASME O&M Working Group on pressure relief devices. These topics include scope issues, thermal relief valve issues, as-found and as-left set-pressure determinations, exclusions from testing, and cold setpoint bench testing. The purpose of this paper is to describe some significant issues being addressed by the O&M Working Group on Pressure Relief Devices (OM-1). The writer is currently the chair of OM-1 and the statements expressed herein represents his personal opinion.

  10. Solar PV O&M Standards and Best Practices - Existing Gaps and Improvement Efforts

    SciTech Connect

    Klise, Geoffrey Taylor; Balfour, John R.; Keating, T. J.

    2014-11-01

    As greater numbers of photovoltaic (PV) systems are being installed, operations & maintenance (O&M) activities will need to be performed to ensure the PV system is operating as designed over its useful lifetime. To mitigate risks to PV system availability and performance, standardized procedures for O&M activities are needed to ensure high reliability and long-term system bankability. Efforts are just getting underway to address the need for standard O&M procedures as PV gains a larger share of U.S. generation capacity. Due to the existing landscape of how and where PV is installed, including distributed generation from small and medium PV systems, as well as large, centralized utility-scale PV, O&M activities will require different levels of expertise and reporting, making standards even more important. This report summarizes recent efforts made by solar industry stakeholders to identify the existing standards and best practices applied to solar PV O&M activities, and determine the gaps that have yet to be, or are currently being addressed by industry.

  11. Solar PV O&M Standards and Best Practices – Existing Gaps and Improvement Efforts

    SciTech Connect

    Klise, Geoffrey Taylor; Balfour, John R.; Keating, T. J.

    2014-11-01

    As greater numbers of photovoltaic (PV) systems are being installed, operations & maintenance (O&M) activities will need to be performed to ensure the PV system is operating as designed over its useful lifetime. To mitigate risks to PV system availability and performance, standardized procedures for O&M activities are needed to ensure high reliability and long-term system bankability. Efforts are just getting underway to address the need for standard O&M procedures as PV gains a larger share of U.S. generation capacity. Due to the existing landscape of how and where PV is installed, including distributed generation from small and medium PV systems, as well as large, centralized utility-scale PV, O&M activities will require different levels of expertise and reporting, making standards even more important. This report summarizes recent efforts made by solar industry stakeholders to identify the existing standards and best practices applied to solar PV O&M activities, and determine the gaps that have yet to be, or are currently being addressed by industry.

  12. Refined phylogenetic structure of an abundant East Asian Y-chromosomal haplogroup O*-M134.

    PubMed

    Ning, Chao; Yan, Shi; Hu, Kang; Cui, Yin-Qiu; Jin, Li

    2016-02-01

    The human Y-chromosome haplogroup O-M134 is one of the most abundant paternal lineages in East Asian populations, comprising ~13% of Han Chinese males, and also common in Kazakh, Korean, Japanese, Thai and so on. Despite its considerable prevalence, its current substructure is poorly resolved with only one downstream marker (M117) previously investigated. Here we address this deficiency by investigating some single-nucleotide polymorphisms (SNPs) previously reported being potentially associated with O-M134 based on high-throughput DNA-sequencing data. Using a panel of 1301 Chinese males we first identified 154 haplogroup O-M134 subjects. We then investigated the phylogenetic structure within this haplogroup using 10 SNPs (F444, F629, F3451, F46, F48, F209, F2887, F3386, F1739 and F152). Two major branches were identified, O-M117 and O-F444 and the latter was further divided into two main subclades, O-F629 and O-F3451, accounting for 10.84 and 0.92% of the Han Chinese, respectively. This update of O-M134 diversification permits better resolution of male lineages in population studies of East Asia.

  13. O/M RATIO MEASUREMENT IN PURE AND MIXED OXIDE FULES - WHERE ARE WE NOW?

    SciTech Connect

    J. RUBIN; ET AL

    2000-12-01

    The oxygen-to-metal (O/M) ratio is one of the most critical parameters of nuclear fuel fabrication, and its measurement is closely monitored for manufacturing process control and to ensure the service behavior of the final product. Thermogravimetry is the most widely used method, the procedure for which has remained largely unchanged since its development some thirty years ago. It was not clear to us, however, that this method is still the optimum one in light of advances in instrumentation, and in the current regulatory environment, particularly with regard to waste management and disposal. As part of the MOX fuel fabrication program at Los Alamos, we conducted a comprehensive review of methods for O/M measurements in UO{sub 2}, PuO{sub 2} and mixed oxide fuels for thermal reactors. A concerted effort was made to access information not available in the open literature. We identified approximately thirty five experimental methods that (a) have been developed with the intent of measuring O/M, (b) provided O/M indirectly by suitable reduction of the measured data, or (c) could provide O/M data with suitable data reduction or when combined with other methods. We will discuss the relative strengths and weaknesses of these methods in their application to current routine and small-lot production environment.

  14. Refined phylogenetic structure of an abundant East Asian Y-chromosomal haplogroup O*-M134

    PubMed Central

    Ning, Chao; Yan, Shi; Hu, Kang; Cui, Yin-Qiu; Jin, Li

    2016-01-01

    The human Y-chromosome haplogroup O-M134 is one of the most abundant paternal lineages in East Asian populations, comprising ~13% of Han Chinese males, and also common in Kazakh, Korean, Japanese, Thai and so on. Despite its considerable prevalence, its current substructure is poorly resolved with only one downstream marker (M117) previously investigated. Here we address this deficiency by investigating some single-nucleotide polymorphisms (SNPs) previously reported being potentially associated with O-M134 based on high-throughput DNA-sequencing data. Using a panel of 1301 Chinese males we first identified 154 haplogroup O-M134 subjects. We then investigated the phylogenetic structure within this haplogroup using 10 SNPs (F444, F629, F3451, F46, F48, F209, F2887, F3386, F1739 and F152). Two major branches were identified, O-M117 and O-F444 and the latter was further divided into two main subclades, O-F629 and O-F3451, accounting for 10.84 and 0.92% of the Han Chinese, respectively. This update of O-M134 diversification permits better resolution of male lineages in population studies of East Asia. PMID:26306641

  15. Key role of CXCL13/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS.

    PubMed

    Pranzatelli, Michael R; Tate, Elizabeth D; McGee, Nathan R; Travelstead, Anna L; Ransohoff, Richard M; Ness, Jayne M; Colliver, Jerry A

    2012-02-29

    To study aberrant B cell trafficking into the CSF in opsoclonus-myoclonus syndrome (OMS), chemoattractants CXCL13 and CXCL12, and B cell frequency and CXCR5 expression, were evaluated. CSF CXCL13 concentration and the CSF/serum ratio were higher in untreated OMS than controls, related directly to OMS severity and inversely to OMS duration, and correlated with CSF B cell frequency and oligoclonal bands. CXCL12 showed the opposite pattern. Selective accumulation of CXCR5+ memory B cells in CSF was found. In ACTH-treated OMS, CXCL13, but not CXCL12, was lower. These data implicate the chemokine/chemoreceptor pair CXCL13/CXR5 in B cell recruitment to the CNS in OMS. CXCL13 and CXCL12 may serve as reciprocal biomarkers of disease activity, but CXCL13 also had utility as a treatment biomarker.

  16. 76 FR 75942 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... 10471; 67 FR 19798; 68 FR 54775;68 FR 64944; 68 FR 69434; 69 FR 19611; 70 FR 30999; 70 FR 46567; 70 FR 48797; 70 FR 53412; 70 FR 57353; 70 FR 61493; 70 FR 67776; 70 FR 72689; 70 FR 74102; 72 FR 39879; 72 FR... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf...

  17. 76 FR 34133 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... 78256; 66 FR 16311; 66 FR 17743; 66 FR 33990; 68 FR 10301; 68 FR 13360; 68 FR 19596; 68 FR 35772; 70 FR 2701; 70 FR 16886; 70 FR 16887; 70 FR 17504; 70 FR 30997; 70 FR 33937; 70 FR 37891; 72 FR 27624; 72 FR... Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316), or you may visit...

  18. 76 FR 55467 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... 44837; 68 FR 48989; 68 FR 54775; 70 FR 2701; 70 FR 16887; 70 FR 30999; 70 FR 41811; 70 FR 42615; 70 FR 46567; 70 FR 53412; 72 FR 39879; 72 FR 40362; 72 FR 52421; 72 FR 52419; 72 FR 62896; 74 FR 34394; 74 FR... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf...

  19. 78 FR 26106 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... 62741; 70 FR 2701; 70 FR 7545; 70 FR 12265; 70 FR 14747; 70 FR 16887; 70 FR 17504; 70 FR 30997; 71 FR... January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief, Medical Programs... for obtaining an exemption from the vision requirements (65 FR 33406; 65 FR 57234; 65 FR 78256; 66 FR...

  20. Effects of the Bacterial Extract OM-85 on Phagocyte Functions and the Stress Response

    PubMed Central

    Baladi, S.; Kantengwa, S.; Donati, Y. R. A.; Polla, B. S.

    1994-01-01

    The effects of the bacterial extract OM-85 on the respiratory burst, intracellular calcium and the stress response have been investigated in human peripheral blood monocytes from normal donors. Activation of the respiratory burst during bacterial phagocytosis has been previously associated with heat shock/stress proteins synthesis. Whereas OM-85 stimulated superoxide production and increased Ca2+ mobilization, it fared to induce synthesis of classical HSPs. The lack of stress protein induction was observed even in the presence of iron which potentiates both oxidative injury and stress protein induction during bacterial phagocytosis. However OM-85 induced a 75–78 kDa protein, which is likely to be a glucose regulated protein (GRP78), and enhanced intracellular expression of interleukin-lβ precursor. PMID:18472933

  1. Gold nanoparticles on OMS-2 for heterogeneously catalyzed aerobic oxidative α,β-dehydrogenation of β-heteroatom-substituted ketones.

    PubMed

    Yoshii, Daichi; Jin, Xiongjie; Yatabe, Takafumi; Hasegawa, Jun-Ya; Yamaguchi, Kazuya; Mizuno, Noritaka

    2016-12-06

    In the presence of Au nanoparticles supported on manganese oxide OMS-2 (Au/OMS-2), various kinds of β-heteroatom-substituted α,β-unsaturated ketones (heteroatom = N, O, S) can be synthesized through α,β-dehydrogenation of the corresponding saturated ketones using O2 (in air) as the oxidant. The catalysis of Au/OMS-2 is truly heterogeneous, and the catalyst can be reused.

  2. Translating the Clinical Outcomes in Routine Evaluation Outcome Measure (CORE-OM) into Lithuanian.

    PubMed

    Viliū nienė, Rima; Evans, Chris; Hilbig, Jan; Pakalniškienė, Vilmantė; Danilevičiūtė, Vita; Laurinaitis, Eugenijus; Navickas, Alvydas

    2013-10-01

    There are no standardized tools in Lithuanian feasible for ongoing routine use to measure the effectiveness of psychotherapeutic treatment. The CORE-OM is a widely used 34-item self-report measure for such purpose. To explore the reliability, validity and sensitivity of the Lithuanian translation of CORE-OM questionnaire. A validation study of the CORE-OM was conducted in the psychiatric clinic attached to Vilnius University. A Lithuanian translation of the English original CORE-OM was prepared by a team of translators. Then 39 psychotherapy outpatients and 187 students were asked to complete the Lithuanian version of the CORE-OM; 66 were tested twice to determine test-retest stability. Analysis included both internal and test-retest reliability, acceptability, influence of gender, principal component analysis and criteria for reliable and clinically significant change. Internal and test-retest reliability were good (0.61-0.94), though somewhat lower for the risk domain (α: 0.57-0.79, Spearman's rho 0.25-0.60). Differences between scores of the clinical and non-clinical samples were large and significant (P < 0.001). Some of the Lithuanian criteria for clinically significant change were a bit lower than those of the original UK criteria (e.g. well-being) and others higher (symptoms, functioning, overall score), illustrating the need for local exploration. In spite of small differences in psychometric properties from the original, the Lithuanian version of the CORE-OM was reliable and sensitive in both clinical and non-clinical settings. It has the potential to become a practical, sensitive and reliable tool for psychotherapists in Lithuania.

  3. Remineralization and preservation of the Organic Matter (OM) in the Peruvian Oxygen Minimum Zone

    NASA Astrophysics Data System (ADS)

    Bretagnon, M.; Paulmier, A.; Garcon, V.; Dewitte, B.; Maes, C.; Campos, F.; Carrasco, E.; Coppola, L.; Depretz de Gesincourt, O.; Gojak, C.; Grelet, J.; Illig, S.; Leblond, N.; Lefevre, D.; Martinez, P.; Oschlies, A.; Panagiotopoulos, C.; Scouarnec, L.; Velazco, F.

    2016-02-01

    The intense surface production in the Eastern Boundary Upwelling Systems (EBUS), linked to the low subsurface ventilation, leads to the formation of the Oxygen Minimum Zone (OMZ). The degradation of Organic Matter (OM) by respiration or remineralization impacts climate (ocean carbon sequestration; greenhouse gases emission (e.g. N2O, CO2)) and ecosystems (nitrogen loss; toxic gas (e.g. H2S) production). Due to the O2 stress, OM fate is an OMZ key-issue. On one hand, the low O2 concentration would imply OM preservation, enhancing the export to the sediments. On the other hand, the intense bacteria activity would imply OM recycling. The Peruvian EBUS, one of the most productive systems with the shallowest oxycline, is the perfect case study to investigate both hypotheses. In order to study the particles fluxes and its variability, sediment traps in the oxycline (35 m) and OMZ core (150 m) were deployed on an instrumented moored line off Lima (12°S) in 2013-2014, as part of the AMOP project (Activities of research dedicated to the Minimum of Oxygen in the eastern Pacific).The particles proportion which reaches the deep trap allows to define mathematically a vertical transfer function, suggesting predominant remineralization and preservation configurations. Concerning OM quality, carbon and nitrogen fluxes are proportional to the matter fluxes, contrary to phosphorus and biogenic silica fluxes. The different configurations derived from the transfer function analysis in terms of both OM quantity and quality can mainly be linked to oxygenation conditions, with a potential remineralization predominance associated with O2 concentration at the oxycline higher than a threshold of 5 µmol/kg. Oxygenation events are alternately associated with a specific influence of SubTropical Water, more or less oxygenated (Surface (STSW) or Under (STUW), respectively).

  4. A double blind multicentre study of OM-8980 and auranofin in rheumatoid arthritis.

    PubMed Central

    Vischer, T L

    1988-01-01

    The therapeutic efficacy of the immunomodulator OM-8980 in rheumatoid arthritis was compared with that of auranofin, an oral gold salt, in a double blind, randomised multicentre study lasting six months. Seventy patients were treated with auranofin and 75 with OM-8980. The patients of both groups improved significantly at three and six months for all the clinical parameters observed: Ritchie index, number of swollen joints, morning stiffness, pain, grip strength, intake of non-steroidal anti-inflammatory drugs, and erythrocyte sedimentation rate. No serious side effects were observed in either group. The patients receiving auranofin had more adverse reactions, mainly affecting the gastrointestinal system. PMID:3041924

  5. Non-Toxic Orbiter Maneuvering System (OMS) and Reaction Control System

    NASA Technical Reports Server (NTRS)

    Hurlbert, Eric A.; Nicholson, Leonard S. (Technical Monitor)

    1999-01-01

    NASA is pursuing the technology and advanced development of a non-toxic (NT) orbital maneuvering system (OMS) and reaction control system (RCS) for shuttle upgrades, RLV, and reusable first stages. The primary objectives of the shuttle upgrades program are improved safety, improved reliability, reduced operations time and cost, improved performance or capabilities, and commonality with future space exploration needs. Non-Toxic OMS/RCS offers advantages in each of these categories. A non-toxic OMS/RCS eliminates the ground hazards and the flight safety hazards of the toxic and corrosive propellants. The cost savings for ground operations are over $24M per year for 7 flights, and the savings increase with increasing flight rate up to $44M per year. The OMS/RCS serial processing time is reduced from 65 days to 13 days. The payload capability can be increased up to 5100 Ibms. The non-toxic OMS/RCS also provides improved space station reboost capability up to 20 nautical miles over the current toxic system of 14 nautical miles. A NT OMS/RCS represents a clear advancement in the SOA over MMH/NTO. Liquid oxygen and ethanol are clean burning, high-density propellants that provide a high degree of commonality with other spacecraft subsystems including life support, power, and thermal control, and with future human exploration and development of space missions. The simple and reliable pressure-fed design uses sub-cooled liquid oxygen at 250 to 350 psia, which allows a propellant to remain cryogenic for longer periods of time. The key technologies are thermal insulation and conditioning techniques are used to maintain the sub-cooling. Phase I successfully defined the system architecture, designed an integrated OMS/RCS propellant tank, analyzed the feed system, built and tested the 870 lbf RCS thrusters, and tested the 6000 lbf OMS engine. Phase 11 is currently being planned for the development and test of full-scale prototype of the system in 1999 and 2000

  6. Distinct effects of Broncho-Vaxom (OM-85 BV) on gp130 binding cytokines

    PubMed Central

    Roth, M; Block, L

    2000-01-01

    BACKGROUND—Broncho-Vaxom (OM-85 BV) is known to support respiratory tract resistance to bacterial infections. In vivo and in vitro studies in animals and humans have shown that the action of the drug is based on the modulation of the host immune response, and it has been found to upregulate interferon γ (IFN-γ) and interleukin (IL)-2, IL-6, and IL-8. These immunomodulatory effects of the compound may explain its stimulation on T helper cells and natural killer cells. Following earlier findings that OM-85 BV induces the synthesis of IL-6, a study was undertaken to investigate its possible effect on other gp130 binding cytokines including IL-11, IL-12, leukaemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neutrophil factor (CNTF). Its modulation of the corresponding receptors of the above mentioned cytokines and of the signal transducer gp130 in human pulmonary fibroblasts and peripheral blood lymphocytes was also studied.
METHODS—Transcription of cytokines was assessed by Northern blot analysis. Secretion of cytokines was analysed using commercially available enzyme linked immunosorbent assay kits. Cytokine receptors and gp130 proteins were determined by Western blot analysis.
RESULTS—OM-85 BV increased the expression of IL-11 in human lung fibroblasts, but not in lymphocytes, in a dose and time dependent manner by maximal fivefold within 20 hours. The compound inhibited serum induced IL-12 expression in peripheral blood lymphocytes but did not induce OSM, LIF, or CNTF at any concentration. In lung fibroblasts the expression of the IL-6 receptor was enhanced fourfold at a concentration of 10 µg/ml OM-85 BV while that of the IL-11 receptor was not altered. In peripheral blood lymphocytes LIF receptor α expression was downregulated in the presence of 10 µg/ml OM-85 BV. At a concentration of 10 µg/ml OM-85 BV enhanced gp130 gene transcription fivefold and increased gp130 protein accumulation in cell membranes by 2.5times

  7. 78 FR 36016 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel OM; Invitation for Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... comments electronically via the Internet at http://www.regulations.gov . All comments will become part of...-2013-0068 at http://www.regulations.gov . Interested parties may comment on the effect this action may... the waiver will have an unduly adverse effect on a U.S.-vessel builder or a business that uses...

  8. Effects of effluent organic matter (EfOM) on the removal of emerging contaminants by ozonation.

    PubMed

    Cai, Ming-Jhih; Lin, Yi-Pin

    2016-05-01

    Removal of emerging contaminants in wastewater treatment is essential to ensure the ecological health of the receiving water bodies. Ozonation is a promising technology to achieve this purpose but important wastewater characteristics affecting the optimal removal efficiency need to be elucidated. Secondary effluents contain effluent organic matter (EfOM), which can react directly with ozone as well as react as the initiator, promoter and inhibitor in the hydroxyl radical (.OH) chain reactions resulting from ozone decomposition. These different reaction modes of EfOM, coupled with alkalinity and pH value, collectively determine the ozone and .OH exposures and the degradation of pharmaceutical compounds by ozonation. In this study, we determined the rate constants of EfOM collected from two municipal wastewater treatment plants in terms of direct ozone reaction, initiation, promotion and inhibition at various pH values (pH 6.0-7.5) and temperatures (10-30 °C). The rate constants of direct reaction and initiation generally increased with the increasing pH value while the rate constants of promotion and inhibition did not vary significantly. All rate constants increased with the increasing temperature. The removal of ibuprofen, acetylsulfamethoxazole and metoprolol in diluted secondary effluent by ozonation can be fairly-well modeled by using the determined rate constants of EfOM.

  9. Controlling O&M Costs of Advanced SMRs using Prognostics and Enhanced Risk Monitoring

    SciTech Connect

    Ramuhalli, Pradeep; Hirt, Evelyn H.; Coles, Garill A.; Meyer, Ryan M.; Coble, Jamie B.; Wood, Richard T.

    2014-02-25

    Advanced small modular reactors (AdvSMRs) can contribute to safe, sustainable, and carbon-neutral energy production. The economics of small reactors (including AdvSMRs) will be impacted by the reduced economy-of-scale savings when compared to traditional light water reactors. The most significant controllable element of the day-to-day costs involves operations and maintenance (O&M). Enhancing affordability of AdvSMRs through technologies that help control O&M costs will be critical to ensuring their practicality for wider deployment.A significant component of O&M costs is the management and mitigation of degradation of components due to their impact on planning maintenance activities and staffing levels. Technologies that help characterize real-time risk of failure of key components are important in this context. Given the possibility of frequently changing AdvSMR plant configurations, approaches are needed to integrate three elements – advanced plant configuration information, equipment condition information, and risk monitors – to provide a measure of risk that is customized for each AdvSMR unit and support real-time decisions on O&M. This article describes an overview of ongoing research into diagnostics/prognostics and enhanced predictive risk monitors (ERM) for this purpose.

  10. Glow experiment documentation of OMS/RCS pod and vertical stabilizer

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Glow experiment documentation of one of the orbital maneuvering system (OMS) reaction control system (RCS) pods and a portion of the vertical stabilizer shows chemoluminescent effectresulting from atomic oxygen impacting the spacecraft and building to the point that the atomic oxygen atoms combine to form molecules of oxygen. The Image Intensifier on NIKON 35mm camera was used to record the glow.

  11. Solid-phase photocatalytic degradation of polyethylene film with manganese oxide OMS-2

    NASA Astrophysics Data System (ADS)

    Liu, Guanglong; Liao, Shuijiao; Zhu, Duanwei; Cui, Jingzhen; Zhou, Wenbing

    2011-01-01

    Solid-phase photocatalytic degradation of polyethylene (PE) film with cryptomelane-type manganese oxide (OMS-2) as photocatalyst was investigated in the ambient air under ultraviolet and visible light irradiation. The properties of the composite films were compared with those of the pure PE film through performing weight loss monitoring, IR spectroscopy, scanning electron microscopic (SEM) and X-ray photoelectron spectroscopy (XPS). The photoinduced degradation of PE-OMS-2 composite films was higher than that of the pure films, while there has been little change under the visible light irradiation. The weight loss of PE-OMS-2 (1.0 wt%) composite films steadily decreased and reached 16.5% in 288 h under UV light irradiation. Through SEM observation there were some cavities on the surface of composite films, but few change except some surface chalking phenomenon occurred in pure PE film. The degradation rate with ultraviolet irradiation is controllable by adjusting the content of OMS-2 particles in PE plastic. Finally, the mechanism of photocatalytic degradation of the composite films was briefly discussed.

  12. Closeup of STS-26 Discovery, OV-103, orbital maneuvering system (OMS) leak

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Closeup of STS-26 Discovery, Orbiter Vehicle (OV) 103, orbital maneuvering system (OMS) reaction control system (RCS) nitrogen tetroxide gas leak was captured by a Cobra borescope and displayed on a video monitor. The borescope has a miniature videocamera at the end of a flexible rubber tube and is able to be maneuvered into other inaccessible locations.

  13. Ortho-isopropoxyphenyl methylcarbamate (OMS-33) as a residual spray for control of anopheline mosquitos

    PubMed Central

    Wright, James W.; Fritz, Roy F.; Hocking, Kay S.; Babione, Robert; Gratz, Norman G.; Pal, Rajindar; Stiles, Alan R.; Vandekar, Milutin

    1969-01-01

    More than 1300 compounds have so far been included in the WHO Programme for Evaluating and Testing New Insecticides, which is designed to disclose compounds that may satisfactorily replace those to which insect vectors of disease have become resistant. The authors describe the successful passage of o-isopropoxyphenyl methylcarbamate (OMS-33) through the first 6 stages of the 7-stage programme that has been established for compounds intended for use against anopheline mosquitos and conclude that this product is suitable for testing in the final stage—large-scale epidemiological evaluation. In operational field trials (at 2 g/m2) OMS-33 has been shown capable of controlling Anopheles stephensi (in Iran), An. gambiae and An. funestus (in Nigeria) for 3-4 months, An. albimanus (in El Salvador) for 2-4 months and An. dthali (in Iran) for 2½ months. It has an airborne effect by which anophelines are killed for a considerable time after OMS-33 has been sprayed, even though they do not make contact with a sprayed surface; this quality would appear advantageous in areas where anophelines enter houses and bite man but do not rest long enough on sprayed surfaces to acquire a lethal dose of insecticide or where significant outdoor biting occurs. The observance of simple safety precautions protects occupants of sprayed houses, spraymen and others from danger. Chemical studies have indicated that commercially produced water-dispersible powders of OMS-33 are stable under field conditions of storage and use. PMID:5306320

  14. Bacterial extract OM-85 BV protects mice against experimental chronic rhinosinusitis

    PubMed Central

    Tao, Yanli; Yuan, Tiejun; Li, Xuechang; Yang, Shuqin; Zhang, Fanping; Shi, Li

    2015-01-01

    Objectives: To investigate the therapeutic effects of OM-85 BV as an adjunctive treatment on experimental chronic rhinosinusitis (CRS) in mice. Methodology: Female BALB/c mice aged 8-12 weeks were sensitized and administrated by intranasal Aspergillus fumigatis (AF) three times per week for 1 week, 3 weeks, 2 months and 3 months (n = 10 each time point). The mice were randomly and equally assigned to four groups: normal control group, model group, OM-85-BV plus amoxicillin group, and isolated amoxicillin group. Inflammatory changes were determined by hematoxylin-eosin (HE) staining. The expression levels of suppressor of cytokine signaling (SOCS) 1, SOCS3, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ in samples were assessed by using real-time PCR (RT-PCR) and Western blotting. Results: There were significantly inflammatory and structural changes between the model and other groups. Compared to the model group, the mRNA expression levels of SOCS1, SOCS3, TNF-α, and IFN-γ were significantly decreased in OM-85-BV plus amoxicillin group and isolated amoxicillin group, along with the protein levels. Conclusion: The bacterial extract OM-85 BV is a low-cost alternatively adjunctive drug to treat CRS with simple oral administration, good safety, and few side effects. PMID:26261565

  15. A view of the Columbia's OMS engine pods during a burn

    NASA Image and Video Library

    2013-11-18

    STS093-347-031 (22-27 July 1999) --- Black space forms the backdrop for this scene of the Orbital Maneuvering System (OMS) engine pods during a thruster burn photographed by one of the astronauts on the aft flight deck of the Space Shuttle Columbia.

  16. Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study

    PubMed Central

    Bodemer, Christine; Guillet, Gerard; Cambazard, Frederic; Boralevi, Franck; Ballarini, Stefania; Milliet, Christian; Bertuccio, Paola; La Vecchia, Carlo; Bach, Jean-François; de Prost, Yves

    2017-01-01

    Background Environmental factors play a major role on atopic dermatitis (AD) which shows a constant rise in prevalence in western countries over the last decades. The Hygiene Hypothesis suggesting an inverse relationship between incidence of infections and the increase in atopic diseases in these countries, is one of the working hypothesis proposed to explain this trend. Objective This study tested the efficacy and safety of oral administration of the bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®), in the treatment of established AD in children. Methods Children aged 6 months to 7 years, with confirmed AD diagnosis, were randomized in a double-blind, placebo-controlled trial to receive, in addition to conventional treatment with emollients and topical corticosteroids, 3.5mg of the bacterial extract OM-85 or placebo daily for 9 months. The primary end-point was the difference between groups in the occurrence of new flares (NF) during the study period, evaluated by Hazard Ratio (HR) derived from conditional Cox proportional hazard regression models accounting for repeated events. Results Among the 179 randomized children, 170 were analysed, 88 in the OM-85 and 82 in the placebo group. As expected most children in both treatment groups experienced at least 1 NF during the study period (75 (85%) patients in the OM-85 group and 72 (88%) in the placebo group). Patients treated with OM-85 as adjuvant therapy had significantly fewer and delayed NFs (HR of repeated flares = 0.80; 95% confidence interval (CI): 0.67–0.96), also when potential confounding factors, as family history of atopy and corticosteroids use, were taken into account (HR = 0.82; 95% CI: 0.69–0.98). No major side effect was reported, with comparable and good tolerability for OM-85 and placebo. Conclusions Results show an adjuvant therapeutic effect of a well standardized bacterial lysate OM-85 on established AD. PMID:28333952

  17. Synthesis of OMS-2/graphite nanocomposites with enhanced activity for pollutants degradation in the presence of peroxymonosulfate.

    PubMed

    Fang, Jia; Li, Jun; Gao, Long; Jiang, Xiwang; Zhang, Jingwen; Xu, Aihua; Li, Xiaoxia

    2017-05-15

    The octahedral molecular sieve manganese oxide (OMS-2) and graphite (Gt) composites (OMS-2/Gt) were prepared by a facile refluxing approach. The structure and morphology of the obtained materials were systematically investigated. The results reveal that OMS-2 nanofibers are uniformly dispersed on the surface of Gt, and the ratio of Mn(3+) species in OMS-2 increases lineally with the increase of Gt dosage. The catalytic activity of OMS-2/Gt was evaluated by the degradation of Acid Orange 7 (AO7) in the presence of peroxymonosulfate (PMS). It is found that the OMS-2/Gt composites show enhanced catalytic performance with the degradation rate lineally correlated with the content of OMS-2 in the catalyst, and even with the ratio of Mn(3+)/Mn(4+). XPS and radical scavenger experiments further indicated that the oxidation of Mn(3+) by PMS system occurs in the system with the formation of hydroxyl radicals contributed to the dye degradation. The catalysts also exhibit good stability and reusability during consecutive cycles. Thus, the environmental friendly OMS-2/Gt composites with low cost, facile synthesis process and high efficiency are very promising catalysts for PMS activation and pollutants degradation. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Selective Activation of Human Dendritic Cells by OM-85 through a NF-kB and MAPK Dependent Pathway

    PubMed Central

    Scutera, Sara; Somma, Paolo; Salvi, Valentina; Musso, Tiziana; Tabbia, Giuseppe; Bardessono, Marco; Pasquali, Christian; Mantovani, Alberto; Sozzani, Silvano; Bosisio, Daniela

    2013-01-01

    OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®), a product made of the water soluble fractions of 21 inactivated bacterial strain patterns responsible for respiratory tract infections, is used for the prevention of recurrent upper respiratory tract infections and acute exacerbations in chronic obstructive pulmonary disease patients. OM-85 is able to potentiate both innate and adaptive immune responses. However, the molecular mechanisms responsible for OM-85 activation are still largely unknown. Purpose of this study was to investigate the impact of OM-85 stimulation on human dendritic cell functions. We show that OM-85 selectively induced NF-kB and MAPK activation in human DC with no detectable action on the interferon regulatory factor (IRF) pathway. As a consequence, chemokines (i.e. CXCL8, CXCL6, CCL3, CCL20, CCL22) and B-cell activating cytokines (i.e. IL-6, BAFF and IL-10) were strongly upregulated. OM-85 also synergized with the action of classical pro-inflammatory stimuli used at suboptimal concentrations. Peripheral blood mononuclear cells from patients with COPD, a pathological condition often associated with altered PRR expression pattern, fully retained the capability to respond to OM-85. These results provide new insights on the molecular mechanisms of OM-85 activation of the immune response and strengthen the rational for its use in clinical settings. PMID:24386121

  19. The Relation between Speech Perception and Phonemic Awareness: Evidence from Low-SES Children and Children with Chronic OM.

    ERIC Educational Resources Information Center

    Nittrouer, Susan

    1996-01-01

    This study of 41 children (ages 7 and 8) studied the effects of low socioeconomic status (SES) and chronic otitis media (OM) on speech perception and phonemic awareness. Findings indicated the children with low SES did poorly on both kinds of tasks whether or not they had chronic OM. (CR)

  20. Development of a New O&M Clinical Competency Evaluation Tool and Examination of Validity and Reliability Evidence

    ERIC Educational Resources Information Center

    Renshaw, Rebecca L.

    2010-01-01

    The goal of this study was to create an evaluation tool that would be the new standard for evaluating clinical competencies of interns in the field of orientation and mobility (O&M). Using results from previous research in this area, specific competency skills were identified and the O&M Clinical Competency Evaluation Matrix (CCEM) was…

  1. The Relation between Speech Perception and Phonemic Awareness: Evidence from Low-SES Children and Children with Chronic OM.

    ERIC Educational Resources Information Center

    Nittrouer, Susan

    1996-01-01

    This study of 41 children (ages 7 and 8) studied the effects of low socioeconomic status (SES) and chronic otitis media (OM) on speech perception and phonemic awareness. Findings indicated the children with low SES did poorly on both kinds of tasks whether or not they had chronic OM. (CR)

  2. Development of a New O&M Clinical Competency Evaluation Tool and Examination of Validity and Reliability Evidence

    ERIC Educational Resources Information Center

    Renshaw, Rebecca L.

    2010-01-01

    The goal of this study was to create an evaluation tool that would be the new standard for evaluating clinical competencies of interns in the field of orientation and mobility (O&M). Using results from previous research in this area, specific competency skills were identified and the O&M Clinical Competency Evaluation Matrix (CCEM) was…

  3. Extracellular secretion of the Borrelia burgdorferi Oms28 porin and Bgp, a glycosaminoglycan binding protein.

    PubMed

    Cluss, Robert G; Silverman, Damon A; Stafford, Thomas R

    2004-11-01

    Borrelia burgdorferi, the Lyme disease pathogen, cycles between its Ixodes tick vector and vertebrate hosts, adapting to vastly different biochemical environments. Spirochete gene expression as a function of temperature, pH, growth phase, and host milieu is well studied, and recent work suggests that regulatory networks are involved. Here, we examine the release of Borrelia burgdorferi strain B31 proteins into conditioned medium. Spirochetes intrinsically radiolabeled at concentrations ranging from 10(7) to 10(9) cells per ml secreted Oms28, a previously characterized outer membrane porin, into RPMI medium. As determined by immunoblotting, this secretion was not associated with outer membrane blebs or cytoplasmic contamination. A similar profile of secreted proteins was obtained for spirochetes radiolabeled in mixtures of RPMI medium and serum-free Barbour-Stoenner-Kelly (BSK II) medium. Proteomic liquid chromatography-tandem mass spectrometry analysis of tryptic fragments derived from strain B31 culture supernatants confirmed the identity of the 28-kDa species as Oms28 and revealed a 26-kDa protein as 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs-2), previously described as Bgp, a glycosaminoglycan-binding protein. The release of Oms28 into the culture medium is more selective when the spirochetes are in logarithmic phase of growth compared to organisms obtained from stationary phase. As determined by immunoblotting, stationary-phase spirochetes released OspA, OspB, and flagellin. Oms28 secreted by strains B31, HB19, and N40 was also recovered by radioimmunoprecipitation. This is the first report of B. burgdorferi protein secretion into the extracellular environment. The possible roles of Oms28 and Bgp in the host-pathogen interaction are considered.

  4. Extracellular Secretion of the Borrelia burgdorferi Oms28 Porin and Bgp, a Glycosaminoglycan Binding Protein

    PubMed Central

    Cluss, Robert G.; Silverman, Damon A.; Stafford, Thomas R.

    2004-01-01

    Borrelia burgdorferi, the Lyme disease pathogen, cycles between its Ixodes tick vector and vertebrate hosts, adapting to vastly different biochemical environments. Spirochete gene expression as a function of temperature, pH, growth phase, and host milieu is well studied, and recent work suggests that regulatory networks are involved. Here, we examine the release of Borrelia burgdorferi strain B31 proteins into conditioned medium. Spirochetes intrinsically radiolabeled at concentrations ranging from 107 to 109 cells per ml secreted Oms28, a previously characterized outer membrane porin, into RPMI medium. As determined by immunoblotting, this secretion was not associated with outer membrane blebs or cytoplasmic contamination. A similar profile of secreted proteins was obtained for spirochetes radiolabeled in mixtures of RPMI medium and serum-free Barbour-Stoenner-Kelly (BSK II) medium. Proteomic liquid chromatography-tandem mass spectrometry analysis of tryptic fragments derived from strain B31 culture supernatants confirmed the identity of the 28-kDa species as Oms28 and revealed a 26-kDa protein as 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs-2), previously described as Bgp, a glycosaminoglycan-binding protein. The release of Oms28 into the culture medium is more selective when the spirochetes are in logarithmic phase of growth compared to organisms obtained from stationary phase. As determined by immunoblotting, stationary-phase spirochetes released OspA, OspB, and flagellin. Oms28 secreted by strains B31, HB19, and N40 was also recovered by radioimmunoprecipitation. This is the first report of B. burgdorferi protein secretion into the extracellular environment. The possible roles of Oms28 and Bgp in the host-pathogen interaction are considered. PMID:15501754

  5. Prevention of respiratory tract infections with bacterial lysate OM-85 bronchomunal in children and adults: a state of the art

    PubMed Central

    2013-01-01

    Respiratory tract infections (RTIs) are a leading cause of morbidity and also represent a cause of death in some parts of the world. The treatment of RTIs implies a continuous search for stronger therapies and represents an economical burden for health services and society. In this context the prevention of infections is absolutely required. The use of bacterial lysates as immuno-modulators to boost immunological response is widely debated. Aim of this review is to summarize the main clinical studies on the effect of the bacterial lysate OM-85 in treating RTIs in susceptible subjects - namely children and chronic obstructive pulmonary disease (COPD)-affected adults. Results from clinical trials and recent systematic reviews are reported. The results show that mean number of RTIs decreases upon treatment with OM-85, as measured by frequency of exacerbations or number of antibiotic courses. Data from systematic reviews indicated that OM-85 is particularly beneficial in children at high risk of RTIs. In COPD-affected adults, clinical studies showed that treatment with OM-85 reduced exacerbations, although systematic reviews did not legitimate the protective effect of OM-85 toward COPD as significant. The use of OM-85 could be efficacious in reducing exacerbation frequency of RTIs in children and adults at risk. However further high-quality studies are needed to better explain the mechanism of action and confirm the beneficial results of OM85. PMID:23692890

  6. Ordered mesoporous silica (OMS) as an adsorbent and membrane for separation of carbon dioxide (CO2).

    PubMed

    Chew, Thiam-Leng; Ahmad, Abdul L; Bhatia, Subhash

    2010-01-15

    Separation of carbon dioxide (CO(2)) from gaseous mixture is an important issue for the removal of CO(2) in natural gas processing and power plants. The ordered mesoporous silicas (OMS) with uniform pore structure and high density of silanol groups, have attracted the interest of researchers for separation of carbon dioxide (CO(2)) using adsorption process. These mesoporous silicas after functionalization with amino groups have been studied for the removal of CO(2). The potential of functionalized ordered mesoporous silica membrane for separation of CO(2) is also recognized. The present paper reviews the synthesis of mesoporous silicas and important issues related to the development of mesoporous silicas. Recent studies on the CO(2) separation using ordered mesoporous silicas (OMS) as adsorbent and membrane are highlighted. The future prospectives of mesoporous silica membrane for CO(2) adsorption and separation are also presented and discussed. Copyright 2009 Elsevier B.V. All rights reserved.

  7. Four years of immunization with OM-85 BV to prevent respiratory infections in HIV+ patients

    PubMed Central

    Capetti, Amedeo; Cossu, Maria Vittoria; Carenzi, Laura; Rizzardini, Giuliano

    2013-01-01

    We report an interventional, non-randomized experience of OM-85 BV immunization in a group of 104 HIV-infected subjects presenting recurrent seasonal respiratory bacterial infections. We compared the number of respiratory events, the use of antibiotics and the cost related to antibiotics before (2005–2006) and after (2008–2011) the introduction of such intervention. The year 2007 was excluded from the analysis since half of the patients were immunized in that year in an exploratory approach. Respiratory infections dropped in all groups but in subjects with recurrent otitis, leading to a reduction in the use of antibiotics. This is the first report of the effect of OM-85 BV in vivo in HIV-infected subjects. PMID:23792443

  8. An advanced regulator for the helium pressurization systems of the Space Shuttle OMS and RCS

    NASA Technical Reports Server (NTRS)

    Wichmann, H.

    1973-01-01

    The Space Shuttle Orbit Maneuvering System and Reaction Control System are pressure-fed rocket propulsion systems utilizing earth storable hypergolic propellants and featuring engines of 6000 lbs and 900 lbs thrust, respectively. The helium pressurization system requirements for these propulsion systems are defined and the current baseline pressurization systems are described. An advanced helium pressure regulator capable of meeting both OMS and RCS helium pressurization system requirements is presented and its operating characteristics and predicted performance characteristics are discussed.

  9. View of the starboard OMS pod of the STS-6 Challenger

    NASA Technical Reports Server (NTRS)

    1983-01-01

    This view centers on the starboard orbital maneuvering system (OMS) pod of the shuttle Challenger during its STS-6 mission. Two pieces of thermal protection system tile appear to have loosened. The view also shows one of the cargo bay television cameras, part of the extravehicular activity (EVA) slide wire system, three handrails and other features on the aft bulkhead. Part of the airborne support equipment (ASE) is in the lower right foreground.

  10. An O(m log m)-Time Algorithm for Detecting Superbubbles.

    PubMed

    Sung, Wing-Kin; Sadakane, Kunihiko; Shibuya, Tetsuo; Belorkar, Abha; Pyrogova, Iana

    2015-01-01

    In genome assembly graphs, motifs such as tips, bubbles, and cross links are studied in order to find sequencing errors and to understand the nature of the genome. Superbubble, a complex generalization of bubbles, was recently proposed as an important subgraph class for analyzing assembly graphs. At present, a quadratic time algorithm is known. This paper gives an O(m log m)-time algorithm to solve this problem for a graph with m edges.

  11. Columbia: The first five flights entry heating data series. Volume 2: The OMS Pod

    NASA Technical Reports Server (NTRS)

    Williams, S. D.

    1983-01-01

    Entry heating flight data and wind tunnel data on the OMS Pod are presented for the first five flights of the Space Shuttle Orbiter. The heating rate data are presented in terms of normalized film heat transfer coefficients as a function of angle-of-attack, Mach number, and normal shock Reynolds number. The surface heating rates and temperatures were obtained via the JSC NONLIN/INVERSE computer program. Time history plots of the surface heating rates and temperatures are also presented.

  12. OMS Pods and Vertical Stabilizer on Space Shuttle Atlantis during STS-132

    NASA Image and Video Library

    2010-05-25

    S132-E-011670 (25 May 2010) --- Backdropped over parts of Michigan and the Canadian province of Ontario, space shuttle Atlantis? vertical stabilizer, orbital maneuvering system (OMS) pods and aft payload bay are featured in this image photographed by an STS-132 on the shuttle during flight day 12 activities. Recognizable features in the photo include Lake St. Clair and parts of Lake Huron and Lake Erie.

  13. Vertical Stabilizer and OMS pods from the aft FD window during STS-123 mission

    NASA Image and Video Library

    2008-03-11

    S123-E-005073 (11 Mar. 2008) --- This view out the aft windows on Endeavour's flight deck was one of a series of images recorded by the STS-123 crewmembers during their first full day in space. The end of the Canadian-built remote manipulator system's robot arm (right edge) along with the shuttle's vertical stabilizer and its two orbital maneuvering system (OMS) pods are visible. A heavily cloud-covered area of Earth fills the top half of the frame.

  14. Thermosensitive omsA mutation of Escherichia coli that causes thermoregulated release of periplasmic proteins.

    PubMed

    Tsuruoka, T; Ito, M; Tomioka, S; Hirata, A; Matsuhashi, M

    1988-11-01

    A mutant of Escherichia coli with a thermosensitive defect, possibly in the outer membrane (omsA mutant), was isolated from E. coli K-12 by mutagenization and selection for thermosensitivity and beta-lactam supersensitivity of growth. The mutant also showed very high sensitivity to other antibiotics, such as macarbomycin, midecamycin, rifampin, and bacitracin. The mutation was recessive to the wild type and was mapped at about 4 min on the E. coli chromosome between fhuA and metD. The mutation caused rapid release into the medium of periplasmic enzymes such as RTEM penicillinase but practically no cytoplasmic enzyme when cells grown at 30 degrees C were transferred to 37 or 42 degrees C. Electron microscopic observations showed many large double-layered vesicles attached to the surface of cells incubated at 42 degrees C. We conclude that the mutant had a mutation that caused a temperature-dependent defect in the outer membrane structure or its assembly (named an oms mutation). The omsA mutant may be useful for production of periplasmic proteins, which it releases into the culture medium on shift up of temperature.

  15. Cosmic age, statefinder, and Om diagnostics in the decaying vacuum cosmology

    NASA Astrophysics Data System (ADS)

    Tong, M. L.; Zhang, Y.

    2009-07-01

    As an extension of the cosmological constant model (ΛCDM), the decaying vacuum (DV) model describes dark energy as a varying vacuum whose energy density decays linearly with the Hubble parameter at late times, ρΛ(t)∝H(t), and produces the matter component. We examine the high-z cosmic age problem in the DV model, and compare it with ΛCDM and the Yang-Mills condensate (YMC) dark energy model. Without employing a dynamical scalar field for dark energy, these three models share a similar behavior of late-time evolution. It is found that the DV model, like the YMC, can accommodate the high-z quasar APM 08279+5255, thus greatly alleviating the high-z cosmic age problem. We also calculate the statefinder (r,s) and the Om diagnostics in the model. It is found that the evolutionary trajectories of r(z) and s(z) in the DV model are similar to those in the kinessence model, but are distinguished from those in ΛCDM and the YMC. The Om(z) in the DV model has a negative slope and its height depends on the matter fraction, while the YMC has a rather flat Om(z), whose magnitude depends sensitively on the coupling.

  16. Improving interpretation of infrared spectra for OM characterization by subtraction of spectra from incinerated samples

    NASA Astrophysics Data System (ADS)

    Ellerbrock, Ruth H.; Gerke, Horst H.; Leue, Martin

    2017-04-01

    Non-destructive methods such as diffuse reflectance infrared Fourier transform spectroscopy (DRIFT) have been applied to characterize organic matter (OM) at intact structural surfaces among others. However, it is often difficult to distinguish effects of organic components on DRIFT signal intensities from those of mineral components. The objective of this study was to re-evaluate DRIFT spectra from intact earthworm burrow walls and coated cracks to improve the interpretation of C-H and C=O bands. We compared DRIFT and transmission Fourier transform infrared (FTIR) spectra of entire samples that were from the same pedogenetic soil horizon, but different in mineral composition and texture (i.e., glacial till versus loess). Spectra of incinerated samples were subtracted from the original spectra. Transmission FTIR and DRIFT spectra were almost identical for entire soil samples. However, the DRIFT spectra were affected by the bulk mode bands (i.e., wavenumbers 2000 to 1700 cm-1) that affected spectral resolution and reproducibility. The ratios between C-H and C=O band intensities as indicator for OM quality obtained with DRIFT were smaller than those obtained from transmission FTIR. A spectral subtraction procedure was found to reduce effects of mineral absorption bands on DRIFT spectra allowing an improved interpretation. DRIFT spectroscopy as a non-destructive method for analyzing OM composition at intact surfaces in structured soils could be calibrated with information obtained with the more detailed transmission FTIR and complementary methods.

  17. Study on optics integrated manufacture technology based on Windows DNA-OM

    NASA Astrophysics Data System (ADS)

    Yu, Min; Yang, Li; Wang, Yong-jan

    2006-02-01

    As the shortcoming and insufficiency of CNC systems applied in optics manufacturing, a design and application based on Windows DNA-OM is presented. After introducing the prime principles and logic structures of Windows DNA-OM, a specific solution of optics integrated manufacture based on this framework is discussed in detail. In this solution, the OPC(OLE for Process Control) technology based on COM(Component Object Model) of Microsoft company is used for CNC equipment in the workshop, and this could provide a general interface for communication of hetero-structure CNC equipment of workshop and so all hetero-structure CNC can be accessed in a simple way. The experience and knowledge of optic manufacturing is stored and integrated in Windows DNA-OM Data part, this data part can guide optics manufacture. By completing this data part, an optics manufacture expert system can be realized. Then the prime characteristics of the integrated manufacture system are given. Finally this system is proved to has a good flexibility and opening, ease realizing, low cost and high feasibility.

  18. Top Operations and Maintenance (O&M) Efficiency Opportunities at DoD/Army Sites - A Guide for O&M/Energy Managers and Practitioners

    SciTech Connect

    Sullivan, Gregory P.; Dean, Jesse D.; Dixon, Douglas R.

    2007-05-25

    This report, sponsored the Army's Energy Engineering Analysis Program, provides the Operations and Maintenance (O&M) Energy manager and practitioner with useful information about the top O&M opportunities consistently found across the DoD/Army sector. The target is to help the DoD/Army sector develop a well-structured and organized O&M program.

  19. OM-X®, Fermented Vegetables Extract Suppresses Antigen-Stimulated Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells and Passive Cutaneous Anaphylaxis Reaction in Mice.

    PubMed

    Itoh, Tomohiro; Miyake, Yasuyoshi; Kasashima, Takuya; Shimomiya, Yoshie; Nakamura, Yuki; Ando, Masashi; Tsukamasa, Yasuyuki; Takahata, Muneaki

    2015-09-01

    OM-X® is a hand-made and naturally manufactured probiotic supplement. This fermented food product is made from vegetables, fruits, seaweeds and mushrooms, using 12 strains of lactic acid bacteria and bifidobacteria. OM-X® is also known to have beneficial health properties, and some of its components show effects on antigen (Ag)-stimulated degranulation activity, indicating that OM-X® may be useful in the treatment of allergy responses and symptoms. In this study, we evaluated the inhibitory effects of OM-X® on Ag-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells, clarified the underlying mechanisms, and determined the active compounds in OM-X® for suppression of degranulation. Treatment with OM-X® gradually suppressed Ag-stimulated degranulation throughout the maturation period. OM-X® also gradually produced melanoidins by lactic acid bacterial fermentation during the maturation process. There was a high correlation between the suppression levels of Ag-stimulated degranulation and the browning of OM-X®. Furthermore, the inhibition of Ag-stimulated degranulation by OM-X® was found to be partially due to the direct inactivation of NADPH oxidase. To elucidate the in vivo effects of OM- X®, type I allergy model mice were orally administered with OM-X®, and the passive cutaneous anaphylaxis (PCA) reaction was measured. OM-X® intake remarkably suppressed the PCA reaction. Taken together, our findings suggest that OMX® could be a beneficial food to ameliorate allergic reactions.

  20. Theory and Observations of Plasma Waves Excited Space Shuttle OMS Burns in the Ionosphere

    NASA Astrophysics Data System (ADS)

    Bernhardt, P. A.; Pfaff, R. F.; Schuck, P. W.; Hunton, D. E.; Hairston, M. R.

    2010-12-01

    Measurements of artificial plasma turbulence were obtained during two Shuttle Exhaust Ionospheric Turbulence Experiments (SEITE) conducted during the flights of the Space Shuttle (STS-127 and STS-129). Based on computer modeling at the NRL PPD and Laboratory for Computational Physics & Fluid Dynamics (LCP), two dedicated burns of the Space Shuttle Orbital Maneuver Subsystem (OMS) engines were scheduled to produce 200 to 240 kg exhaust clouds that passed over the Air Force Research Laboratory (AFRL) Communications, Navigation, and Outage Forecast System (C/NOFS) satellite. This operation required the coordination by the DoD Space Test Program (STP), the NASA Flight Dynamics Officer (FDO), the C/NOFS payload operations, and the C/NOFS instrument principal investigators. The first SEITE mission used exhaust from a 12 Second OMS burn to deposit 1 Giga-Joules of energy into the upper atmosphere at a range of 230 km from C/NOFS. The burn was timed so C/NOFS could fly though the center of the exhaust cloud at a range of 87 km above the orbit of the Space Shuttle. The first SEITE experiment is important because is provided plume detection by ionospheric plasma and electric field probes for direct sampling of irregularities that can scatter radar signals. Three types of waves were detected by C/NOFS during and after the first SEITE burn. With the ignition and termination of the pair of OMS engines, whistler mode signals were recorded at C/NOFS. Six seconds after ignition, a large amplitude electromagnetic pulse reached the satellite. This has been identified as a fast magnetosonic wave propagating across magnetic field lines to reach the electric field (VEFI) sensors on the satellite. Thirty seconds after the burn, the exhaust cloud reach C/NOFS and engulfed the satellite providing very strong electric field turbulence along with enhancements in electron and ion densities. Kinetic modeling has been used to track the electric field turbulence to an unstable velocity

  1. Effects of precursor and sulfation on OMS-2 catalyst for oxidation of ethanol and acetaldehyde at low temperatures.

    PubMed

    Wang, Renhu; Li, Junhua

    2010-06-01

    Volatile organic compounds (VOCs) emitted from many industrial processes and transportation activities are major organic pollutants in the atmosphere and toxic to human health. Octahedral molecular sieve (OMS-2) catalysts with different precursors and sulfate-acidified OMS-2 catalysts were synthesized using refluxing methods. The catalysts were investigated on complete oxidation of ethanol and acetaldehyde, and both demonstrated good reactivity. However, acidification resulted in a decrease in activity. OMS-2 catalyst using MnSO(4) as precursor exhibited the best catalytic performance and, thus, was selected for catalyst deactivation by sulfur dioxide. The results of this study suggested that the Mn-O bond of OMS-2 catalysts was the main determinant of the catalytic activity toward oxygenated VOC oxidation and weaker acid sites benefited higher acetaldehyde selectivity. Catalyst deactivation resulted from a strong but slow chemical interaction between the Mn-O bond and sulfur dioxide, probably forming manganese sulfate.

  2. Determining the Spatial and Seasonal Variability in OM/OC Ratios across the U.S. Using Multiple Regression

    EPA Science Inventory

    Data from the Interagency Monitoring of Protected Visual Environments (IMPROVE) network are used to estimate organic mass to organic carbon (OM/OC) ratios across the United States by extending previously published multiple regression techniques. Our new methodology addresses com...

  3. Determining the Spatial and Seasonal Variability in OM/OC Ratios across the U.S. Using Multiple Regression

    EPA Science Inventory

    Data from the Interagency Monitoring of Protected Visual Environments (IMPROVE) network are used to estimate organic mass to organic carbon (OM/OC) ratios across the United States by extending previously published multiple regression techniques. Our new methodology addresses com...

  4. Enhanced Photocatalytic Degradation of Methyl Orange Dye under the Daylight Irradiation over CN-TiO₂ Modified with OMS-2.

    PubMed

    Hassan, Mohamed Elfatih; Chen, Jing; Liu, Guanglong; Zhu, Duanwei; Cai, Jianbo

    2014-12-12

    In this study, CN-TiO₂ was modified with cryptomelane octahedral molecular sieves (OMS-2) by the sol-gel method based on the self-assembly technique to enhance its photocatalytic activity under the daylight irradiation. The synthesized samples were characterized by X-ray diffraction (XRD), UV-vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR) and porosimeter analysis. The results showed that the addition of OMS-2 in the sol lead to higher Brunauer-Emmett-Teller (BET) surface area, pore volume, porosity of particle after heat treatment and the specific surface area, porosity, crystallite size and pore size distribution could be controlled by adjusting the calcination temperature. Compared to the CN-TiO₂-400 sample, CN-TiO₂/OMS-2-400 exhibited greater red shift in absorption edge of samples in visible region due to the OMS-2 coated. The enhancement of photocatalytic activity of CN-TiO₂/OMS-2 composite photocatalyst was subsequently evaluated for the degradation of the methyl orange dye under the daylight irradiation in water. The results showed that the methyl orange dye degradation rate reach to 37.8% for the CN-TiO₂/OMS-2-400 sample under the daylight irradiation for 5 h, which was higher than that of reference sample. The enhancement in daylight photocatalytic activities of the CN-TiO₂/OMS samples could be attributed to the synergistic effects of OMS-2 coated, larger surface area and red shift in adsorption edge of the prepared sample.

  5. OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria.

    PubMed

    Lesnik, Chen; Cohen, Yifat; Atir-Lande, Avigail; Schuldiner, Maya; Arava, Yoav

    2014-12-09

    It is well established that import of proteins into mitochondria can occur after their complete synthesis by cytosolic ribosomes. Recently, an additional model was revived, proposing that some proteins are imported co-translationally. This model entails association of ribosomes with the mitochondrial outer membrane, shown to be mediated through the ribosome-associated chaperone nascent chain-associated complex (NAC). However, the mitochondrial receptor of this complex is unknown. Here, we identify the Saccharomyces cerevisiae outer membrane protein OM14 as a receptor for NAC. OM14Δ mitochondria have significantly lower amounts of associated NAC and ribosomes, and ribosomes from NAC[Δ] cells have reduced levels of associated OM14. Importantly, mitochondrial import assays reveal a significant decrease in import efficiency into OM14Δ mitochondria, and OM14-dependent import necessitates NAC. Our results identify OM14 as the first mitochondrial receptor for ribosome-associated NAC and reveal its importance for import. These results provide a strong support for an additional, co-translational mode of import into mitochondria.

  6. OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria

    PubMed Central

    Lesnik, Chen; Cohen, Yifat; Atir-Lande, Avigail; Schuldiner, Maya; Arava, Yoav

    2014-01-01

    It is well established that import of proteins into mitochondria can occur after their complete synthesis by cytosolic ribosomes. Recently, an additional model was revived, proposing that some proteins are imported co-translationally. This model entails association of ribosomes with the mitochondrial outer membrane, shown to be mediated through the ribosome-associated chaperone nascent chain-associated complex (NAC). However, the mitochondrial receptor of this complex is unknown. Here, we identify the Saccharomyces cerevisiae outer membrane protein OM14 as a receptor for NAC. OM14Δ mitochondria have significantly lower amounts of associated NAC and ribosomes, and ribosomes from NAC[Δ] cells have reduced levels of associated OM14. Importantly, mitochondrial import assays reveal a significant decrease in import efficiency into OM14Δ mitochondria, and OM14-dependent import necessitates NAC. Our results identify OM14 as the first mitochondrial receptor for ribosome-associated NAC and reveal its importance for import. These results provide a strong support for an additional, co-translational mode of import into mitochondria. PMID:25487825

  7. Simultaneous removal of phosphorus and EfOM using MIEX, coagulation, and low-pressure membrane filtration.

    PubMed

    Kim, Hyun-Chul; Timmes, Thomas C; Dempsey, Brian A

    2015-01-01

    The feasibility of using magnetic ion exchange (MIEX) treatment, in-line alum coagulation, and low-pressure membrane filtration was investigated for the simultaneous removal of total phosphorus (TP) and effluent organic matter (EfOM) from biologically treated wastewater. The focus was also placed on minimizing fouling of polyvinylidene fluoride and polyethersulfone membranes, which are the most commonly used low-pressure membranes in new and retrofit wastewater treatment plants. MIEX alone was effective for the removal of EfOM, and MIEX plus a small alum dose was very effective in removing both EfOM and TP. MIEX removed phosphorus, but organic acids in EfOM were preferentially removed, and the effects of competing anions on the removal of EfOM were insignificant. All the pretreatment strategies decreased the resistance to filtration. The greatest decrease in fouling was achieved by using MIEX (15 mL L⁻¹) plus a very low dose of alum (∼0.5 mg Al L⁻¹). Sweep floc coagulation using alum and without MIEX also significantly decreased fouling but did not effectively remove EfOM and produced high floc volume that could be problematic for inside-out hollow-fibre modules. The addition of these reagents into rapid mix followed by membrane filtration would provide operational simplicity and could be easily retrofitted at existing membrane filtration facilities.

  8. 76 FR 15360 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ...; 68 FR 13360; 68 FR 15037; 69 FR 52741; 70 FR 12265; 70 FR 14747; 70 FR 16887; 70 FR 2701; 70 FR 7545... Federal Register on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf... exemption from the vision requirements (63 FR 66226; 64 FR 16517; 65 FR 20245; 65 FR 57230; 65 FR 66286; 65...

  9. OM-FBA: Integrate Transcriptomics Data with Flux Balance Analysis to Decipher the Cell Metabolism.

    PubMed

    Guo, Weihua; Feng, Xueyang

    2016-01-01

    Constraint-based metabolic modeling such as flux balance analysis (FBA) has been widely used to simulate cell metabolism. Thanks to its simplicity and flexibility, numerous algorithms have been developed based on FBA and successfully predicted the phenotypes of various biological systems. However, their phenotype predictions may not always be accurate in FBA because of using the objective function that is assumed for cell metabolism. To overcome this challenge, we have developed a novel computational framework, namely omFBA, to integrate multi-omics data (e.g. transcriptomics) into FBA to obtain omics-guided objective functions with high accuracy. In general, we first collected transcriptomics data and phenotype data from published database (e.g. GEO database) for different microorganisms such as Saccharomyces cerevisiae. We then developed a "Phenotype Match" algorithm to derive an objective function for FBA that could lead to the most accurate estimation of the known phenotype (e.g. ethanol yield). The derived objective function was next correlated with the transcriptomics data via regression analysis to generate the omics-guided objective function, which was next used to accurately simulate cell metabolism at unknown conditions. We have applied omFBA in studying sugar metabolism of S. cerevisiae and found that the ethanol yield could be accurately predicted in most of the cases tested (>80%) by using transcriptomics data alone, and revealed valuable metabolic insights such as the dynamics of flux ratios. Overall, omFBA presents a novel platform to potentially integrate multi-omics data simultaneously and could be incorporated with other FBA-derived tools by replacing the arbitrary objective function with the omics-guided objective functions.

  10. A Xhosa language translation of the CORE-OM using South African university student samples.

    PubMed

    Campbell, Megan M; Young, Charles

    2016-10-01

    The translation of well established psychometric tools from English into Xhosa may assist in improving access to psychological services for Xhosa speakers. The aim of this study was to translate the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM), a measure of general distress and dysfunction developed in the UK, into Xhosa for use at South African university student counselling centres. The CORE-OM and embedded CORE-10 were translated into Xhosa using a five-stage translation design. This design included (a) forward-translation, (b) back-translation, (c) committee approach, (d) qualitative piloting, and (e) quantitative piloting on South African university students. Clinical and general samples were drawn from English-medium South African universities. Clinical samples were generated from university student counselling centres. General student samples were generated through random stratified cluster sampling of full-time university students. Qualitative feedback from the translation process and results from quantitative piloting of the 34-item CORE-OM English and Xhosa versions supported the reduction of the scale to 10 items. This reduced scale is referred to as the South African CORE-10 (SA CORE-10). A measurement and structural model of the SA CORE-10 English version was developed and cross-validated using an English-speaking university student sample. Equivalence of this model with the SA CORE-10 Xhosa version was investigated using a first-language Xhosa-speaking university sample. Partial measurement equivalence was achieved at the metric level. The resultant SA CORE-10 Xhosa and English versions provide core measures of distress and dysfunction. Additional, culture- and language-specific domains could be added to increase sensitivity and specificity.

  11. PLB, vertical tail, OMS pods above Earth with moon in distant background

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Payload bay (PLB) equipment, payloads, and experiments include remote manipulator system (RMS) stowed on port side sill longeron, Development Flight Instrument (DFI) pallet with High Capacity Heat Pipe Experiment, Special Philatelic Covers in two large storage (mail) boxes, Evaluation of Oxygen Interaction with Materials (EOIM) experiment trays, and Advanced Flexible Reusable Surface Insulation (AFRSI) blanket in foreground and Payload Flight Test Article (PFTA) behind DFI pallet. Vertical tail with orbital maneuvering system (OMS) pods at base points to Earth's cloud-covered surface with gibbous moon in distance.

  12. Chromosomal and Genetic Analysis of a Human Lung Adenocarcinoma Cell Line OM

    PubMed Central

    Li, Yong-Wu; Bai, Lin; Dai, Lyu-Xia; He, Xu; Zhou, Xian-Ping

    2016-01-01

    Background: Lung cancer has become the leading cause of death in many regions. Carcinogenesis is caused by the stepwise accumulation of genetic and chromosomal changes. The aim of this study was to investigate the chromosome and gene alterations in the human lung adenocarcinoma cell line OM. Methods: We used Giemsa banding and multiplex fluorescence in situ hybridization focusing on the human lung adenocarcinoma cell line OM to analyze its chromosome alterations. In addition, the gains and losses in the specific chromosome regions were identified by comparative genomic hybridization (CGH) and the amplifications of cancer-related genes were also detected by polymerase chain reaction (PCR). Results: We identified a large number of chromosomal numerical alterations on all chromosomes except chromosome X and 19. Chromosome 10 is the most frequently involved in translocations with six different interchromosomal translocations. CGH revealed the gains on chromosome regions of 3q25.3-28, 5p13, 12q22-23.24, and the losses on 3p25-26, 6p25, 6q26-27, 7q34-36, 8p22-23, 9p21-24, 10q25-26.3, 12p13.31-13.33 and 17p13.1-13.3. And PCR showed the amplification of genes: Membrane metalloendopeptidase (MME), sucrase-isomaltase (SI), butyrylcholinesterase (BCHE), and kininogen (KNG). Conclusions: The lung adenocarcinoma cell line OM exhibited multiple complex karyotypes, and chromosome 10 was frequently involved in chromosomal translocation, which may play key roles in tumorigenesis. We speculated that the oncogenes may be located at 3q25.3-28, 5p13, 12q22-23.24, while tumor suppressor genes may exist in 3p25-26, 6p25, 6q26-27, 7q34-36, 8p22-23, 9p21-24, 10q25-26.3, 12p13.31-13.33, and 17p13.1-13.3. Moreover, at least four genes (MME, SI, BCHE, and KNG) may be involved in the human lung adenocarcinoma cell line OM. PMID:26879013

  13. Summary of LO2/Ethanol OMS/RCS Technology and Advanced Development 99-2744

    NASA Technical Reports Server (NTRS)

    Curtis, Leslie A.; Hurlbert, Eric A.

    1999-01-01

    NASA is pursuing non-toxic propellant technologies applicable to RLV and Space Shuttle orbital maneuvering system (OMS) and reaction control system (RCS). The primary objectives of making advancements in an OMS/RCS system are improved safety, reliability, and reduced operations and maintenance cost, while meeting basic operational and performance requirements. An OMS/RCS has a high degree of direct interaction with the vehicle and crew and requires subsystem and components that are compatible with integration into the vehicle with regard to external mold-line, power, and thermal control. In July 1997, a Phase I effort for the technology and advanced development of an upgrade of the space shuttle was conducted to define the system architecture, propellant tank, feed system, RCS thrusters, and OMS engine. Phase I of the project ran from July 1997 to October 1998. Phase II is currently being planned for the development and test of full-scale prototype of the system in 1999 and 2000. The choice of pressure-fed liquid oxygen (LO2) and ethanol is the result of numerous trade studies conducted from 1980 to 1996. Liquid oxygen and ethanol are clean burning, high-density propellants that provide a high degree of commonality with other spacecraft subsystems including life support, power, and thermal control, and with future human exploration and development of space missions. The key to this pressure-fed system is the use of subcooled liquid oxygen at 350 psia. In this approach, there is 80 degrees R of subcooling, which means that boil-off will not occur until the temperature has risen 80 R. The sub-cooling results naturally from loading propellants at 163 R, which is the saturation temperature at 14.7 psia, and then pressurizing to 350 psia on the launch pad. Thermal insulation and conditioning techniques are then used to limit the LO2 temperature to 185 R maximum, and maintain the sub-cooling. The other key is the wide temperature range of ethanol, -173 F to +300 F, which

  14. Biodiversity Data Interoperability Issues: on the Opportunity of Exploiting O&M for Biotic Data Management

    NASA Astrophysics Data System (ADS)

    Oggioni, A.; Tagliolato, P.; Schleidt, K.; Carrara, P.; Grellet, S.; Sarretta, A.

    2016-02-01

    The state of the art in biodiversity data management unfortunately encompases a plethora of diverse data formats. Compared to other research fields, there is a lack in harmonization and standardization of these data. While data from traditional biodiversity collections (e.g. from museums) can be easily represented by existing standard as provided by TDWG, the growing number of field observations stemming from both VGI activities (e.g. iNaturalist) as well as from automated systems (e.g. animal biotelemetry) would at the very least require upgrades of current formats. Moreover, from an eco-informatics perspective, the integration and use of data from different scientific fields is the norm (abiotic data, geographic information, etc.); the possibility to represent this information and biodiversity data in a homogeneous way would be an advantage for interoperability, allowing for easy integration across environmental media. We will discuss the possibility to exploit the Open Geospatial Consortium/ISO standard, Observations and Measurements (O&M) [1], a generic conceptual model developed for observation data but with strong analogies with the biodiversity-oriented OBOE ontology [2]. The applicability of OGC O&M for the provision of biodiviersity occurence data has been suggested by the INSPIRE Cross Thematic Working Group on Observations & Measurements [3], Inspire Environmental Monitoring Facilities Thematic Working Group [4] and New Zealand Environmental Information Interoperability Framework [5]. This approach, in our opinion, could be an advantage for the biodiversity community. We will provide some examples for encoding biodiversity occurence data using the O&M standard in addition to highlighting the advatages offered by O&M in comparison to other representation formats. [1] Cox, S. (2013). Geographic information - Observations and measurements - OGC and ISO 19156. [2] Madin, J., Bowers, S., Schildhauer, M., Krivov, S., Pennington, D., & Villa, F. (2007). An

  15. Cosmological reconstruction and Om diagnostic analysis of Einstein-Aether theory

    NASA Astrophysics Data System (ADS)

    Pasqua, Antonio; Chattopadhyay, Surajit; Momeni, Davood; Raza, Muhammad; Myrzakulov, Ratbay; Faizal, Mir

    2017-04-01

    In this paper, we analyze the cosmological models in Einstein-Aether gravity, which is a modified theory of gravity in which a time-like vector field breaks the Lorentz symmetry. We use this formalism to analyse different cosmological models with different behavior of the scale factor. In this analysis, we use a certain functional dependence of the Dark Energy (DE) on the Hubble parameter H. It will be demonstrated that the Aether vector field has a non-trivial effect on these cosmological models. We also perform the Om diagnostic in Einstein-Aether gravity and we fit the parameters of the cosmological models using recent observational data.

  16. Characterization of a novel β-barrel protein (AtOM47) from the mitochondrial outer membrane of Arabidopsis thaliana

    PubMed Central

    Li, Lu; Kubiszewski-Jakubiak, Szymon; Radomiljac, Jordan; Wang, Yan; Law, Simon R.; Keech, Olivier; Narsai, Reena; Berkowitz, Oliver; Duncan, Owen; Murcha, Monika W.; Whelan, James

    2016-01-01

    In plant cells, mitochondria are major providers of energy and building blocks for growth and development as well as abiotic and biotic stress responses. They are encircled by two lipid membranes containing proteins that control mitochondrial function through the import of macromolecules and metabolites. Characterization of a novel β-barrel protein, OUTER MEMBRANE PROTEIN 47 (OM47), unique to the green lineage and related to the voltage-dependent anion channel (VDAC) protein family, showed that OM47 can complement a VDAC mutant in yeast. Mutation of OM47 in Arabidopsis thaliana by T-DNA insertion had no effect on the import of proteins, such as the β-barrel proteins translocase of the outer membrane 40 (TOM40) or sorting and assembly machinery 50 (SAM50), into mitochondria. Molecular and physiological analyses revealed a delay in chlorophyll breakdown, higher levels of starch, and a delay in the induction of senescence marker genes in the mutant lines. While there was a reduction of >90% in OM47 protein in mitochondria isolated from 3-week-old om47 mutants, in mitochondria isolated from 8-week-old plants OM47 levels were similar to that of the wild type. This recovery was achieved by an up-regulation of OM47 transcript abundance in the mutants. Combined, these results highlight a role in leaf senescence for this plant-specific β-barrel protein, probably mediating the recovery and recycling of chloroplast breakdown products by transporting metabolic intermediates into and out of mitochondria. PMID:27811077

  17. Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1.

    PubMed

    Bareth, Bettina; Nikolov, Miroslav; Lorenzi, Isotta; Hildenbeutel, Markus; Mick, David U; Helbig, Christin; Urlaub, Henning; Ott, Martin; Rehling, Peter; Dennerlein, Sven

    2016-05-15

    The mitochondrial cytochrome c oxidase assembles in the inner membrane from subunits of dual genetic origin. The assembly process of the enzyme is initiated by membrane insertion of the mitochondria-encoded Cox1 subunit. During complex maturation, transient assembly intermediates, consisting of structural subunits and specialized chaperone-like assembly factors, are formed. In addition, cofactors such as heme and copper have to be inserted into the nascent complex. To regulate the assembly process, the availability of Cox1 is under control of a regulatory feedback cycle in which translation of COX1 mRNA is stalled when assembly intermediates of Cox1 accumulate through inactivation of the translational activator Mss51. Here we isolate a cytochrome c oxidase assembly intermediate in preparatory scale from coa1Δ mutant cells, using Mss51 as bait. We demonstrate that at this stage of assembly, the complex has not yet incorporated the heme a cofactors. Using quantitative mass spectrometry, we define the protein composition of the assembly intermediate and unexpectedly identify the putative methyltransferase Oms1 as a constituent. Our analyses show that Oms1 participates in cytochrome c oxidase assembly by stabilizing newly synthesized Cox1.

  18. Code cases for implementing risk-based inservice testing in the ASME OM code

    SciTech Connect

    Rowley, C.W.

    1996-12-01

    Historically inservice testing has been reasonably effective, but quite costly. Recent applications of plant PRAs to the scope of the IST program have demonstrated that of the 30 pumps and 500 valves in the typical plant IST program, less than half of the pumps and ten percent of the valves are risk significant. The way the ASME plans to tackle this overly-conservative scope for IST components is to use the PRA and plant expert panels to create a two tier IST component categorization scheme. The PRA provides the quantitative risk information and the plant expert panel blends the quantitative and deterministic information to place the IST component into one of two categories: More Safety Significant Component (MSSC) or Less Safety Significant Component (LSSC). With all the pumps and valves in the IST program placed in MSSC or LSSC categories, two different testing strategies will be applied. The testing strategies will be unique for the type of component, such as centrifugal pump, positive displacement pump, MOV, AOV, SOV, SRV, PORV, HOV, CV, and MV. A series of OM Code Cases are being developed to capture this process for a plant to use. One Code Case will be for Component Importance Ranking. The remaining Code Cases will develop the MSSC and LSSC testing strategy for type of component. These Code Cases are planned for publication in early 1997. Later, after some industry application of the Code Cases, the alternative Code Case requirements will gravitate to the ASME OM Code as appendices.

  19. 78 FR 67452 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... 69434; 69 FR 19611; 70 FR 48797; 70 FR 53412; 70 FR 57353; 70 FR 61493; 70 FR 67776; 70 FR 72689; 70 FR... January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief, Medical Programs... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR...

  20. 76 FR 25762 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... 62741; 70 FR 2701; 70 FR 7545; 70 FR 12265; 70 FR 14747; 70 FR 17504; 70 FR 30997; 70 FR 16886; 70 FR... Federal Register on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR...

  1. A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11.

    PubMed

    Cohen-Tannoudji, M; Vandormael-Pournin, S; Le Bras, S; Coumailleau, F; Babinet, C; Baldacci, P

    2000-09-15

    The embryonic lethal phenotype observed when DDK females are crossed with males from other strains results from a deleterious interaction between the egg cytoplasm and the paternal pronucleus soon after fertilization. We have previously mapped the Om locus responsible for this phenotype, called the DDK syndrome, to an approximately 2-cM region of chromosome 11. Here, we report the generation of a physical map of 28 yeast and bacterial artificial chromosome clones encompassing the entire genetic interval containing the Om locus. This contig, spanning approximately 2 Mb, was used to map precisely genes and genetic markers of the region. We determined the maximum physical interval for Om to be 1400 kb. In addition, 11 members of the Scya gene family were found to be organized into two clusters at the borders of the Om region. Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome. Copyright 2000 Academic Press.

  2. A genetic test to determine the origin of maternal transmission ratio distortion. Meiotic drive at the mouse Om locus.

    PubMed Central

    Pardo-Manuel de Villena, F; de la Casa-Esperon, E; Briscoe, T L; Sapienza, C

    2000-01-01

    We have shown previously that the progeny of crosses between heterozygous females and C57BL/6 males show transmission ratio distortion at the Om locus on mouse chromosome 11. This result has been replicated in several independent experiments. Here we show that the distortion maps to a single locus on chromosome 11, closely linked to Om, and that gene conversion is not implicated in the origin of this phenomenon. To further investigate the origin of the transmission ratio distortion we generated a test using the well-known effect of recombination on maternal meiotic drive. The genetic test presented here discriminates between unequal segregation of alleles during meiosis and lethality, based on the analysis of genotype at both the distorted locus and the centromere of the same chromosome. We used this test to determine the cause of the transmission ratio distortion observed at the Om locus. Our results indicate that transmission ratio distortion at Om is due to unequal segregation of alleles to the polar body at the second meiotic division. Because the presence of segregation distortion at Om also depends on the genotype of the sire, our results confirm that the sperm can influence segregation of maternal chromosomes to the second polar body. PMID:10628992

  3. Theoretical studies of structure, stability, and chemical bonding on oxohydride OM{sub 4}H{sub 6} complexes

    SciTech Connect

    Rykova, E.A.; Klimenko; Grigorev, A.I.

    1996-02-15

    The results of ab initio RHF/3-21G, RHF/6-31G*, and MP2/6-31G**//HF/6-31G* calculations for 10 possible configurations of OM{sub 4}H{sub 6} molecules (MO{center_dot}3MH{sub 2}, M = Be, Mg) are reported. Five isomers of OBe{sub 4}H{sub 6} and three isomers of OMg{sub 4}H{sub 6} have been found within and energy range of {approximately} 15 kcal mol{sup -1}. The {open_quotes}lanternlike{close_quotes} C{sub 3v} structure is the most favorable one for both complexes. Both molecules OM{sub 4}H{sub 6} are stable to decomposition through all of the studied pathways. Chemical bonding in the OM{sub k} polyhedra containing two-, three-, and four-coordinated oxygen atoms is discussed. 15 refs., 1 fig., 6 tab.

  4. Obesity-resistant S5B rats showed great cocaine conditioned place preference than the obesity-prone OM rats

    SciTech Connect

    Thanos, P.K.; Wang, G.; Thanos, P.K..; Kim, R.; Cho, J.; Michaelides, M.; Anderson, B.J.; Primeaux, S.D.; Bray, G.A.; Wang, G.-J.; Robinson, J.K.; Volkow, N.D.

    2010-12-01

    Dopamine (DA) and the DA D2 receptor (D2R) are involved in the rewarding and conditioned responses to food and drug rewards. Osborne-Mendel (OM) rats are genetically prone and S5B/P rats are genetically resistant to obesity when fed a high-fat diet. We hypothesized that the differential sensitivity of these two rat strains to natural rewards may also be reflected in sensitivity to drugs of abuse. Therefore, we tested whether OM and S5B/P rats showed a differential preference to cocaine using conditioned place preference (CPP). To also evaluate whether there is specific involvement of the D2R in this differential conditioning sensitivity, we then tested whether the D2R agonist bromocriptine (BC) would differentially affect the effects of cocaine in the two strains. OM and S5B/P rats were conditioned with cocaine (5 or 10 mg/kg) in one chamber and saline in another for 8 days. Rats were then tested for cocaine preference. The effects of BC (0.5, 1, 5, 10, 20 mg/kg) on cocaine preference were then assessed in subsequent test sessions. OM rats did not show a significant preference for the cocaine-paired chamber on test day. Only the S5B/P rats showed cocaine CPP. Later treatment with only the highest dose of BC resulted in reduced cocaine CPP in S5B/P rats when treated with 5 mg/kg cocaine and in OM rats treated with 10 mg/kg cocaine. Our results indicated that obesity-resistant S5B rats showed greater cocaine CPP than the obesity-prone OM rats. These findings do not support a theory of common vulnerability for reinforcer preferences (food and cocaine). However, they show that BC reduced cocaine conditioning effects supporting at least a partial regulatory role of D2R in conditioned responses to drugs.

  5. Application of magnetic OMS-2 in sequencing batch reactor for treating dye wastewater as a modulator of microbial community.

    PubMed

    Pan, Fei; Yu, Yang; Xu, Aihua; Xia, Dongsheng; Sun, Youmin; Cai, Zhengqing; Liu, Wen; Fu, Jie

    2017-10-15

    The potential and mechanism of synthesized magnetic octahedral molecular sieve (Fe3O4@OMS-2) nanoparticles in enhancing the aerobic microbial ability of sequencing batch reactor (SBR) for treating dye wastewater have been revealed in this study. The addition of Fe3O4@OMS-2 of 0.25g/L enhanced the decolorization of SBRs with an operation cycle of 24h by more than 20%. The 16S rRNA gene high-throughput sequencing indicated Fe3O4@OMS-2 increased the microbial richness and diversity of SBRs, and more importantly, promoted the potential dye-degrading bacteria. After a series of enriching and screening, four bacterial strains with the considerable decolorizing ability were isolated from SBRs, designating Alcaligenes faecalis FP-G1, Bacillus aryabhattai FP-F1, Escherichia fergusonii FP-D1 and Rhodococcus ruber FP-E1, respectively. The growth and decolorization of these pure strains were promoted in the presence of Fe3O4@OMS-2, which agrees with the result of high-throughput sequencing. Monitoring dissolved Fe/Mn ions and investigating the change of oxidation states of Fe/Mn species discovered OMS-2 composition played the critical role in modulating the microbial community. The significant enhancement of Mn-oxidizing/-reducing bacteria suggested microbial Mn redox may be the key action mechanism of Fe3O4@OMS-2, which can provide numerous benefits for the microbial community and decolorization of SBRs. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Ocular Motor Score (OMS): a clinical tool to evaluating ocular motor functions in children. Intrarater and inter-rater agreement.

    PubMed

    Olsson, Monica; Teär Fahnehjelm, Kristina; Rydberg, Agneta; Ygge, Jan

    2015-08-01

    Ocular motor score (OMS) is a new clinical test protocol for evaluating ocular motor functions in children and young adults. OMS is a set of 15 important and relevant non-invasive ocular motor function parameters derived from clinical practice. The aim of the study was to evaluate OMS according to intrarater and inter-rater agreement. Forty children aged 4-10 years, 23 girls median age 6.5 (range 4.3-9.3) and 17 boys median age 5.8 (range 4.1-9.8) were included. The ocular motor functions were assessed and scored according to the OMS protocol. The examinations were videotaped. To obtain the intrarater agreement, the first author examined and scored the children twice, first in the clinic and 2 weeks later by watching the videotape. To obtain the inter-rater agreement, three other raters independently scored the ocular motor function of the children by watching the videotapes. The overall observed intrarater agreement was 88%, and the observed inter-rater agreement between the three raters was 80%. For none of the subtests was there an observed intrarater agreement lower than 65%. Three of the subtests had an observed inter-rater agreement of 65% or below. Overall there was high observed intra- and inter-rater agreement for the OMS test protocol. Subtests such as saccades and smooth pursuit were more difficult for raters to score similarly according the clinical OMS test protocol. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  7. Full solar spectrum light driven thermocatalysis with extremely high efficiency on nanostructured Ce ion substituted OMS-2 catalyst for VOCs purification

    NASA Astrophysics Data System (ADS)

    Hou, Jingtao; Li, Yuanzhi; Mao, Mingyang; Yue, Yuanzheng; Greaves, G. Neville; Zhao, Xiujian

    2015-01-01

    The nanostructured Ce ion substituted cryptomelane-type octahedral molecular sieve (OMS-2) catalyst exhibits strong absorption in the entire solar spectrum region. The Ce ion substituted OMS-2 catalyst can efficiently transform the absorbed solar energy to thermal energy, resulting in a considerable increase of temperature. By combining the efficient photothermal conversion and thermocatalytic activity of the Ce ion substituted OMS-2 catalyst, we carried out full solar spectrum, visible-infrared, and infrared light driven catalysis with extremely high efficiency. Under the irradiation of full solar spectrum, visible-infrared, and infrared light, the Ce ion substituted OMS-2 catalyst exhibits extremely high catalytic activity and excellent durability for the oxidation of volatile organic pollutants such as benzene, toluene, and acetone. Based on the experimental evidence, we propose a novel mechanism of solar light driven thermocatalysis for the Ce ion substituted OMS-2 catalyst. The reason why the Ce ion substituted OMS-2 catalyst exhibits much higher catalytic activity than pure OMS-2 and CeO2/OMS-2 nano composite under the full solar spectrum irradiation is discussed.The nanostructured Ce ion substituted cryptomelane-type octahedral molecular sieve (OMS-2) catalyst exhibits strong absorption in the entire solar spectrum region. The Ce ion substituted OMS-2 catalyst can efficiently transform the absorbed solar energy to thermal energy, resulting in a considerable increase of temperature. By combining the efficient photothermal conversion and thermocatalytic activity of the Ce ion substituted OMS-2 catalyst, we carried out full solar spectrum, visible-infrared, and infrared light driven catalysis with extremely high efficiency. Under the irradiation of full solar spectrum, visible-infrared, and infrared light, the Ce ion substituted OMS-2 catalyst exhibits extremely high catalytic activity and excellent durability for the oxidation of volatile organic pollutants

  8. Effect of preparation method on the surface characteristics and activity of the Pd/OMS-2 catalysts for the oxidation of carbon monoxide, toluene, and ethyl acetate

    NASA Astrophysics Data System (ADS)

    Liu, Lisha; Song, Yong; Fu, Zhidan; Ye, Qing; Cheng, Shuiyuan; Kang, Tianfang; Dai, Hongxing

    2017-02-01

    The cryptomelane-type manganese oxide octahedral molecular sieve (OMS-2)-supported Pd (0.5 wt% Pd/OMS-2-DP, 0.5 wt% Pd/OMS-2-PI, and 0.5 wt% Pd/OMS-2-EX) catalysts were prepared by the deposition-precipitation, pre-incorporation, and ion-exchanging strategies, respectively. It is shown that the preparation method exerted an important effect on the physicochemical property of the sample. Among the OMS-2-supported Pd catalysts, 0.5 wt% Pd/OMS-2-DP possessed the highest surface (Mn2+ + Mn3+)/Mn4+ atomic ratio and the highest surface Pd loading and acid sites. The 0.5 wt% Pd/OMS-2 catalysts outperformed the Pd-free counterpart, among which 0.5 wt% Pd/OMS-2-DP presented the best catalytic activity (T50% and T90% were 25 and 55 °C for CO oxidation, 240 and 285 °C for toluene oxidation, and 160 and 200 °C for ethyl acetate oxidation, respectively). We believe that the high Pd surface loading, high surface atomic ratio of (Mn2+ + Mn3+)/Mn4+, and good low-temperature reducibility, good oxygen mobility, and high acidity were responsible for the excellent performance of the 0.5 wt% Pd/OMS-2-DP catalyst.

  9. Origami microfluidic paper-analytical-devices (omPAD) for sensing and diagnostics.

    PubMed

    Punjiya, Meera; Chung Hee Moon; Yu Chen; Sonkusale, Sameer

    2016-08-01

    Recent research activities in the area of low-cost sensing and diagnostics that are realized on cellulosic paper substrate are presented. First a three-dimensional origami paper-based analytical device (omPAD) with multiple electrochemical sensors, an integrated sample reservoir and tight integration with a custom CMOS potentiostat is presented. Second, an optical sensor array with built-in microfluidic channel for sample delivery is presented. The sensors are fabricated using a combination of wax printing and screen-printing using a solution based approach in ambient conditions without the need for expensive fabrication equipment or a cleanroom. Readout is based on using existing consumer grade electronic devices like flatbed scanner (for optical sensor) or custom designed CMOS potentiostat (for electrochemical sensors). Together the 3D paper-based analytical device with integrated sensor, microfluidics and portable readout instrumentation demonstrates a low-cost, self-contained system suitable for sensing and point-of-care diagnostics.

  10. An engineering evaluation of the Space Shuttle OMS engine after 5 orbital flights

    NASA Technical Reports Server (NTRS)

    David, D.

    1983-01-01

    Design features, performances on the first five flights, and condition of the Shuttle OMS engines are summarized. The engines were designed to provide a vacuum-fed 6000 lb of thrust and a 310 sec specific impulse, fueled by a combination of N2O4 and monomethylhydrazine (MMH) at a mixture ratio of 1.65. The design lifetime is 1000 starts and 15 hr of cumulative firing duration. The engine assembly is throat gimballed and features yaw actuators. No degradation of the hot components was observed during the first five flights, and the injector pattern maintained a uniform, enduring level of performance. An increase in the take-off loads have led to enhancing the wall thickness in the nozzle in affected areas. The engine is concluded to be performing to design specifications and is considered an operational system.

  11. Results of ionospheric parameters measurements during injections of exhaust streams of TSC "Progress" OMS

    NASA Astrophysics Data System (ADS)

    Khakhinov, Vitaly; Alsatkin, Sergey; Medvedev, Andrey; Kushnarev, Dmitriy; Lebedev, Valentin; Potekhin, Alexander; Ratovsky, Konstantin; Shpynev, Boris

    Since 2006 we have carried out active space experiments using the transport spacecraft (TSC) "Progress" and the ground-base Radio-Optic Complex of ISTP SB RAS including Irkutsk Incoherent Scatter Radar (IISR). Engine burns of TSC orbital maneuvering subsystem (OMS) were used as a source of ionospheric disturbances and changing radar signature characteristics of TSC. The flight altitudes were about 340 km. The amount of engine exhaust products was varied from 2 to 11 kg. The flow directions relative to IISR and amount of injected exhaust products were changed from flight to flight. The flows directed to IISR were almost parallel to the geomagnetic field line. For these cases the most pronounced effects were observed, the electron density depletion reached 20-40

  12. Clinical Benefits of Memantine Treatment for Alzheimer's Disease in the Okayama Memantine Study II (OMS II).

    PubMed

    Matsuzono, Kosuke; Yamashita, Toru; Ohta, Yasuyuki; Hishikawa, Nozomi; Koike, Makoto; Sato, Kota; Kono, Syoichiro; Deguchi, Kentaro; Nakano, Yumiko; Abe, Koji

    2015-01-01

    The clinical benefits of memantine, depending on the baseline cognitive and affective conditions in real world dementia clinics, have not been completely examined. We performed the "Okayama Memantine Study II (OMS II)" to retrospectively evaluate the clinical effects of memantine monotherapy (n = 38) in Alzheimer's disease (AD) patients using seven batteries to assess dementia at the baseline, at 3, 6, and 12 months. Additionally, we divided 163 AD patients treated with memantine into two subgroups depending on the baseline cognitive score of the Mini-Mental State Examination (MMSE): the MMSE <15 group (n = 36) and the baseline MMSE ≥15 group (n = 127). We also analyzed 71 AD patients based on the baseline behavioral and psychological symptoms of dementia (BPSD) severity using Abe's BPSD score (ABS). Memantine monotherapy maintained cognitive functions until 6 months of treatment, but showed a decrease at 12 months ( *p <  0.05 versus baseline). However, memantine monotherapy greatly improved BPSD symptoms until 12 months ( *p <  0.05,  **p <  0.01) and maintained other affective functions as well as the activity of daily living. Memantine treatment showed similar effects, regardless of the baseline cognitive functions, but showed better effects on ABS for higher baseline cognitive functions. Memantine treatment greatly improved ABS depending on baseline BPSD severity. Our present OMS II showed that memantine monotherapy improved BPSD until 12 months. The higher baseline cognitive subgroup (MMSE ≥15) and the worse baseline BPSD subgroup were expected to show better effects with memantine.

  13. Spectroscopic Classification of ASASSN-16of, ASASSN-16ok, and ASASSN-16om as Type Ia SNe

    NASA Astrophysics Data System (ADS)

    Strader, Jay; Chomiuk, Laura; Salinas, Ricardo

    2016-12-01

    We obtained optical spectra of ASASSN-16of (ATel #9815), ASASSN-16ok (ATel #9826), and ASASSN-16om (ATel #9827), on UT 2016 December 22.3, 22.1, and 22.1, respectively, with the Goodman Spectrograph on the SOAR telescope.

  14. OMS-2-Supported Cu Hydroxide-Catalyzed Benzoxazoles Synthesis from Catechols and Amines via Domino Oxidation Process at Room Temperature.

    PubMed

    Meng, Xu; Wang, Yanmin; Wang, Yuanguang; Chen, Baohua; Jing, Zhenqiang; Chen, Gexin; Zhao, Peiqing

    2017-07-07

    In the presence of manganese oxide octahedral molecular sieve (OMS-2) supported copper hydroxide Cu(OH)x/OMS-2, aerobic synthesis of benzoxazoles from catechols and amines via domino oxidation/cyclization at room temperature is achieved. This heterogeneous benzoxazoles synthesis initiated by the efficient oxidation of catechols over Cu(OH)x/OMS-2 tolerates a variety of substrates, especially amines containing sensitive groups (hydroxyl, cyano, amino, vinyl, ethynyl, ester, and even acetyl groups) and heterocycles, which affords functionalized benzoxazoles in good to excellent yields by employing low catalyst loading (2 mol % Cu). The characterization and plausible catalytic mechanism of Cu(OH)x/OMS-2 are described. The notable features of our catalytic protocol such as the use of air as the benign oxidant and EtOH as the solvent, mild conditions, ease of product separation, being scalable up to the gram level, and superior reusability of catalyst (up to 10 cycles) make it more practical and environmentally friendly for organic synthesis.

  15. STS-46 Atlantis', OV-104's, vertical tail and OMS pods lit up by RCS jet firing

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-46 Atlantis', Orbiter Vehicle (OV) 104's, vertical tail and orbital maneuvering system (OMS) pods are highlighted by the glow of the reaction control system (RCS) jet firings. OV-104 was at an altitude of 128 nautical miles. The remote manipulator system (RMS) arm is partially visible stowed along the port side sill longeron.

  16. Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana.

    PubMed

    Panigrahi, Rashmi; Whelan, James; Vrielink, Alice

    2014-06-01

    The study aims to gain insight into the mode of ligand recognition by tetratricopeptide repeat (TPR) domains of chloroplast translocon at the outer envelope of chloroplast (Toc64) and mitochondrial Om64, two paralogous proteins that mediate import of proteins into chloroplast and mitochondria, respectively. Chaperone proteins associate with precursor proteins in the cytosol to maintain them in a translocation competent conformation and are recognized by Toc64 and Om64 that are located on the outer membrane of the target organelle. Heat shock proteins (Hsp70) and Hsp90 are two chaperones, which are known to play import roles in protein import. The C-termini of these chaperones are known to interact with the TPR domain of chloroplast Toc64 and mitochondrial Om64 in Arabidopsis thaliana (At). Using a molecular dynamics approach and binding energy calculations, we identify important residues involved in the interactions. Our findings suggest that the TPR domain from AtToc64 has higher affinity towards C-terminal residues of Hsp70. The interaction occurs as the terminal helices move towards each other enclosing the cradle on interaction of AtHsp70 with the TPR domain. In contrast, the TPR domain from AtOm64 does not discriminate between the C-termini of Hsp70 and Hsp90. These binding affinities are discussed with respect to our knowledge of protein targeting and specificity of protein import into endosymbiotic organelles in plant cells. Copyright © 2014 John Wiley & Sons, Ltd.

  17. Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells.

    PubMed

    Zavašnik-Bergant, Tina; Vidmar, Robert; Sekirnik, Andreja; Fonović, Marko; Salát, Jiří; Grunclová, Lenka; Kopáček, Petr; Turk, Boris

    2017-01-01

    To ensure successful feeding tick saliva contains a number of inhibitory proteins that interfere with the host immune response and help to create a permissive environment for pathogen transmission. Among the potential targets of the salivary cystatins are two host cysteine proteases, cathepsin S, which is essential for antigen- and invariant chain-processing, and cathepsin C (dipeptidyl peptidase 1, DPP1), which plays a critical role in processing and activation of the granule serine proteases. Here, the effect of salivary cystatin OmC2 from Ornithodoros moubata was studied using differentiated MUTZ-3 cells as a model of immature dendritic cells of the host skin. Following internalization, cystatin OmC2 was initially found to inhibit the activity of several cysteine cathepsins, as indicated by the decreased rates of degradation of fluorogenic peptide substrates. To identify targets, affinity chromatography was used to isolate His-tagged cystatin OmC2 together with the bound proteins from MUTZ-3 cells. Cathepsins S and C were identified in these complexes by mass spectrometry and confirmed by immunoblotting. Furthermore, reduced increase in the surface expression of MHC II and CD86, which are associated with the maturation of dendritic cells, was observed. In contrast, human inhibitor cystatin C, which is normally expressed and secreted by dendritic cells, did not affect the expression of CD86. It is proposed that internalization of salivary cystatin OmC2 by the host dendritic cells targets cathepsins S and C, thereby affecting their maturation.

  18. Structure and composition of Fe-OM co-precipitates that form in soil-derived solutions

    NASA Astrophysics Data System (ADS)

    Fritzsche, Andreas; Schröder, Christian; Wieczorek, Arkadiusz K.; Händel, Matthias; Ritschel, Thomas; Totsche, Kai U.

    2015-11-01

    Iron oxides represent a substantial fraction of secondary minerals and particularly affect the reactive properties of natural systems in which they formed, e.g. in soils and sediments. Yet, it is still obscure how transient conditions in the solution will affect the properties of in situ precipitated Fe oxides. Transient compositions, i.e. compositions that change with time, arise due to predominant non-equilibrium states in natural systems, e.g. between liquid and solid phases in soils. In this study, we characterize Fe-OM co-precipitates that formed in pH-neutral exfiltrates from anoxic topsoils under transient conditions. We applied soil column outflow experiments, in which Fe2+ was discharged with the effluent from anoxic soil and subsequently oxidized in the effluent due to contact with air. Our study features three novel aspects being unconsidered so far: (i) the transient composition of soil-derived solutions, (ii) that pedogenic Fe oxides instead of Fe salts serve as major source for Fe2+ in soil solution and (iii) the presence of exclusively soil-derived organic and inorganic compounds during precipitation. The experiments were carried out with two topsoil materials that differed in composition, texture and land use. Derived from Mössbauer spectroscopy, broad distributions in quadrupole splittings (0-2 mm s-1) and magnetic hyperfine fields (35-53 T) indicated the presence of low-crystalline ferrihydrite and even lower crystalline Fe phases in all Fe-OM co-precipitates. There was no unequivocal evidence for other Fe oxides, i.e. lepidocrocite and (nano)goethite. The Fe-OM co-precipitates contained inorganic (P, sulfate, silicate, Al, As) and organic compounds (proteins, polysaccharides), which were concurrently discharged from the soils. Their content in the Fe-OM co-precipitates was controlled by their respective concentration in the soil-derived solution. On a molar basis, OC and Fe were the main components in the Fe-OM co-precipitates (OC/Fe ratio = 0

  19. Full solar spectrum light driven thermocatalysis with extremely high efficiency on nanostructured Ce ion substituted OMS-2 catalyst for VOCs purification.

    PubMed

    Hou, Jingtao; Li, Yuanzhi; Mao, Mingyang; Yue, Yuanzheng; Greaves, G Neville; Zhao, Xiujian

    2015-02-14

    The nanostructured Ce ion substituted cryptomelane-type octahedral molecular sieve (OMS-2) catalyst exhibits strong absorption in the entire solar spectrum region. The Ce ion substituted OMS-2 catalyst can efficiently transform the absorbed solar energy to thermal energy, resulting in a considerable increase of temperature. By combining the efficient photothermal conversion and thermocatalytic activity of the Ce ion substituted OMS-2 catalyst, we carried out full solar spectrum, visible-infrared, and infrared light driven catalysis with extremely high efficiency. Under the irradiation of full solar spectrum, visible-infrared, and infrared light, the Ce ion substituted OMS-2 catalyst exhibits extremely high catalytic activity and excellent durability for the oxidation of volatile organic pollutants such as benzene, toluene, and acetone. Based on the experimental evidence, we propose a novel mechanism of solar light driven thermocatalysis for the Ce ion substituted OMS-2 catalyst. The reason why the Ce ion substituted OMS-2 catalyst exhibits much higher catalytic activity than pure OMS-2 and CeO2/OMS-2 nano composite under the full solar spectrum irradiation is discussed.

  20. Comparison of ozone and HO· induced conversion of effluent organic matter (EfOM) using ozonation and UV/H2O2 treatment.

    PubMed

    Audenaert, W T M; Vandierendonck, D; Van Hulle, S W H; Nopens, I

    2013-05-01

    This study experimentally examined the impact of oxidation on the properties of effluent organic matter (EfOM) using two different oxidation techniques: ozonation and UV/H2O2 treatment. Multiple surrogates for EfOM related to its spectral properties, molecular size, concentration, polarity and biodegradability were used to study the oxidant induced conversions. Spectral calculations as differential absorbance spectra (DAS) and absorbance slope index (ASI) were applied for the first time to describe EfOM oxidation and proved to be useful to unravel differences in working mechanism between ozone and hydroxyl radical (HO) induced transformation of EfOM. Effluent ozonation inherently led to significant HO production as a result of electron transfers between ozone and electron rich moieties of EfOM. HO production increased as function of ozone dose and was strongly correlated to UV absorption at 254 nm (UV254). During the UV moderated process, pseudo steady-state behaviour of the HO concentration was observed. Ozone decomposition was extremely sensitive to EfOM reactivity. Most likely, the degree of dissociation of EfOM controlled its reactivity towards ozone. The pH effect was quantified by calculating the pseudo-first order decay constant for ozone as function of reaction time and pH. Treatment with both processes led to more oxygen rich, less hydrophobic and more biodegradable EfOM.

  1. Oral vaccine (OM-89) in the recurrent urinary tract infection prophylaxis: a realistic systematic review with meta-analysis.

    PubMed

    Taha Neto, K A; Nogueira Castilho, L; Reis, L O

    2016-05-01

    To evaluate the efficacy of Escherichia Coli extract (OM-89) in the prophylaxis of recurrent uncomplicated urinary tract infection (UTI) through a contemporary systematic review and meta-analysis. Inclusion criteria were double-blind randomized trials using orally administrated OM-89, 6mg daily, during three months with a minimum of three months of monitoring. Outcomes were the frequency of bacteriuria in 3 and 6 months, dysuria in 6 months and UTI in 6 months. PubMed, MEDLINE, Cochrane Collaboration and their key references. After analysis by three independent reviewers, 15 double-blind randomized trials were identified, 10 papers excluded due to methods flaws and 5 used for data analysis due to double blinding and reporting drop-outs. Among 5 selected studies the date of publication ranged from 1985 to 2005, totalizing 396 patients in the OM-89 group and 392 in the control group. Overall, there were 61 dropouts in the control group and 76 in the OM-89 group. As a major limitation there was no appropriate description of their methodologies and none of the studies described conflict of interest or commitment to the pharmaceutical industry. All studies were multi-centric, except for two, which showed no clarity on allocation concealment. All studies show benefit in favor of vaccine. Current literature on prospective randomized controlled trials evaluating the use of oral OM-89 vaccine in the recurrent UTI prophylaxis is of low quality, limited to the first six months only and with variable definition of bacteriuria and UTI. Although all studies show benefit in favor of vaccine, no robust trial was identified, resulting in a high heterogeneity in the data analyzed. Also, publication bias could not be excluded and future higher quality studies are warranted adding intermediate (>12 months) and long-term follow-up. Copyright © 2014 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. Evaluation of extended reach capability of 40G BiDi VCSEL-based WDM transmission over OM4 multimode fibers

    NASA Astrophysics Data System (ADS)

    Chen, Xin; Hurley, Jason E.; Bickham, Scott; Abbott, John; Chow, Bruce; Coleman, Doug; Li, Ming-Jun

    2016-02-01

    40G BiDi is a commercial WDM transceiver with duplex LC connectivity for transmissions over multimode fibers. In this paper, we evaluate the transmission performance of 40G BiDi over OM4 fibers. We have carefully selected OM4 fibers with the lowest and highest peak wavelengths around 850 nm to evaluate the reach capability for 40G BiDi transmission. We demonstrated that the OM4 fiber with the lowest peak wavelength can transmit error free over 325 m while the OM4 fiber with the highest peak wavelength can transmit up to 350-390 m. In both cases, the maximum lengths are much longer than 150 m and 200 m specified for OM4 and wideband MMF transmissions, respectively. We also measured the transceiver encircled flux and found that it was tighter than the encircled flux standard, which may be a factor favoring long system reach at 900 nm.

  3. Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist {alpha}-conotoxin OmIA that discriminates {alpha}3 vs. {alpha}6 nAChR subtypes

    SciTech Connect

    Chi, Seung-Wook; Kim, Do-Hyoung; Olivera, Baldomero M.; McIntosh, J. Michael; Han, Kyou-Hoon . E-mail: khhan600@kribb.re.kr

    2006-06-23

    {alpha}-Conotoxin OmIA from Conus omaria is the only {alpha}-conotoxin that shows a {approx}20-fold higher affinity to the {alpha}3{beta}2 over the {alpha}6{beta}2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of {alpha}-conotoxin OmIA by nuclear magnetic resonance spectroscopy. {alpha}-Conotoxin OmIA has an '{omega}-shaped' overall topology with His{sup 5}-Asn{sup 12} forming an {alpha}-helix. Structural features of {alpha}-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related {alpha}4/7 subfamily conotoxins. Reduced size of the hydrophilic area in {alpha}-conotoxin OmIA seems to be associated with the reduced affinity towards the {alpha}6{beta}2 nAChR subtype.

  4. EDITORIAL: Special section: Selected papers from OMS'05, the 1st Topical Meeting of the European Optical Society on Optical Microsystems (OMS)

    NASA Astrophysics Data System (ADS)

    Rendina, Ivo; Fazio, Eugenio; Ferraro, Pietro

    2006-07-01

    OMS'05 is the first international conference wholly dedicated to optical microsystems. It was organized by the European Optical Society (EOS) in the frame of its international topical meeting activity and was held in Italy, September 2005, amidst the wonderful scenery of the Island of Capri. A possible definition of an optical microsystem is a complex system, able to perform one or more sensing and actuation functions, where optical devices are integrated in a smart way with electronic, mechanical and sensing components by taking advantage of the progress in micro- and nano-technologies. The increasing interest in this field arises from the expected applications that would significantly improve the quality of life. The list of possibilities offered by the optical microsystem enabling technologies is very long and seems to increase day by day. We are not only thinking about the next generation of optical telecommunication networks and computers, but also about low-cost, compact microsystems for environmental monitoring, in order to improve safety in the avionic and automotive fields, medical diagnostics and proteomic/genomic studies, or just finding general applications in several industrial fields. The goal of the conference was to involve scientists and young researchers from the main public and private laboratories, giving them the opportunity to present new scientific results and compare their know-how in the exciting and emerging field of optical microsystems. We believe that we succeeded in this. More than 200 scientists from all over the world attended the conference. We had more than 100 oral presentations and approximately 20 from the keynote lectures and invited speeches. It was an opportunity to define the most recent progress carried out in the field and to outline the possible road-map leading to the expected results in the industrial and social fields. We strongly believe that research and technology are closely interconnected at present and cannot

  5. Exomic variants of an elderly cohort of Brazilians in the ABraOM database.

    PubMed

    Naslavsky, Michel Satya; Yamamoto, Guilherme Lopes; de Almeida, Tatiana Ferreira; Ezquina, Suzana A M; Sunaga, Daniele Yumi; Pho, Nam; Bozoklian, Daniel; Sandberg, Tatiana Orli Milkewitz; Brito, Luciano Abreu; Lazar, Monize; Bernardo, Danilo Vicensotto; Amaro, Edson; Duarte, Yeda A O; Lebrão, Maria Lúcia; Passos-Bueno, Maria Rita; Zatz, Mayana

    2017-07-01

    Brazilians are highly admixed with ancestry from Europe, Africa, America, and Asia and yet still underrepresented in genomic databanks. We hereby present a collection of exomic variants from 609 elderly Brazilians in a census-based cohort (SABE609) with comprehensive phenotyping. Variants were deposited in ABraOM (Online Archive of Brazilian Mutations), a Web-based public database. Population representative phenotype and genotype repositories are essential for variant interpretation through allele frequency filtering; since elderly individuals are less likely to harbor pathogenic mutations for early- and adult-onset diseases, such variant databases are of great interest. Among the over 2.3 million variants from the present cohort, 1,282,008 were high-confidence calls. Importantly, 207,621 variants were absent from major public databases. We found 9,791 potential loss-of-function variants with about 300 mutations per individual. Pathogenic variants on clinically relevant genes (ACMG) were observed in 1.15% of the individuals and were correlated with clinical phenotype. We conducted incidence estimation for prevalent recessive disorders based upon heterozygous frequency and concluded that it relies on appropriate pathogenicity assertion. These observations illustrate the relevance of collecting demographic data from diverse, poorly characterized populations. Census-based datasets of aged individuals with comprehensive phenotyping are an invaluable resource toward the improved understanding of variant pathogenicity. © 2017 Wiley Periodicals, Inc.

  6. Synthesis of OMS Materials and Investigation of Their Acceptor-Donor Characteristics.

    PubMed

    Grajek, H; Paciura-Zadrożna, J; Choma, J; Michalski, E; Witkiewicz, Z

    2012-10-01

    Three ordered mesoporous siliceous (OMS) materials known as MCM41s-unmodified MCM-41C16 ("C16"), and two MCM41s with different surface functionalities: MCM-41C16-SH ("C16-SH") and MCM-41C16-NH2 ("C16-NH2")-were synthesized and studied by inverse gas chromatography in order to determine their acceptor-donor properties. The specific retention volumes of nonpolar and polar probes that were chromatographed on these ordered mesoporous silica adsorbents were evaluated under infinite dilution conditions. Two methods were employed to calculate the standard free energy of adsorption, ΔGads, of each chromatographed probe on the basis its specific retention volume. These ΔGads values were then employed to estimate the van der Waals contribution and the specific contribution of the free surface energy for each MCM41. DN values (donor numbers, based on the Gutmann scale) and AN* values (acceptor numbers, based on the Riddle-Fowkes scale) were employed to determine the values of parameters that characterize the ability of the MCM41s to act as electron acceptors (parameter: KA) and donors (parameter: KD). Considering the different compositions of the probes, each of which has different acceptor-donor properties, a new chromatographic test to supplement the Grob test is suggested.

  7. Effect of Increased Immunosuppression on Developmental Outcome of Opsoclonus Myoclonus Syndrome (OMS).

    PubMed

    Mitchell, Wendy G; Wooten, Amelia A; O'Neil, Sharon H; Rodriguez, Jenny G; Cruz, Rosa E; Wittern, Rachael

    2015-07-01

    Opsoclonus myoclonus syndrome (OMS) produces long-term cognitive, behavioral, and motor deficits. Objective was to see if more aggressive treatment improved outcome. Assessment included opsoclonus myoclonus syndrome rating, developmental/cognitive and motor assessment, and adaptive behavior. Fourteen subjects completed testing. Nine had neuroblastoma. Onset was at 10 to 35 months; onset to diagnosis: 2 days to 14 months, and onset to first treatment: 5 days to 15 months. Initial treatment was corticotropin (12), oral steroids (3), plus intravenous immunoglobulin in all. Ten received rituximab, 5 cyclophosphamide. Age at testing ranged from 2.5 to 10.3 years. Adaptive Behavior Score (11 subjects), mean 93.5; estimated Intelligence Quotient/Developmental Quotient mean 93.5; Motor: mean 92.8. Residual opsoclonus myoclonus syndrome symptoms at the time of the evaluation were generally minor; opsoclonus myoclonus syndrome scores ranged from 0 to 6. Comparison to previously reported opsoclonus myoclonus syndrome subjects showed improved outcomes: Adaptive behavior, cognitive and motor scores were significantly higher (P < .001) in new subjects. Outcomes have improved with more aggressive immunosuppression, with most opsoclonus myoclonus syndrome survivors now functioning at or near normal.

  8. Advantages and limitations of OM, SEM, TEM and AFM in the study of ancient decorated pottery

    NASA Astrophysics Data System (ADS)

    Arenas-Alatorre, J.; Silva-Velazquez, Y.; Alva Medina, A.; Rivera, M.

    2010-03-01

    This paper presents results from the study of two fragments of pre-Hispanic pottery, decorated with red pigment, using Optical Microscopy (OM), Scanning Electron Microscopy (SEM), High Resolution Transmission Electron Microscopy (HRTEM), Atomic Force Microscopy (AFM) and Magnetic Force Microscopy (MFM). Capabilities and limitations of these techniques in the analysis of archaeological material are highlighted with special emphasis on TEM, AFM and MFM due to their contribution in the study of the pigment layer at micro and nano scale. The analyzed samples come from the archaeological sites of El Tajin and Xochicalco, both in Mexico. Results of conventional TEM and HRTEM analysis of the red pigment showed nanometric Fe2O3 particles in both samples but different particle shape and size distributions: specimen from El Tajin presented irregular particles between 50-100 nm while that from Xochicalco exhibited semispherical shapes in the 3-25 nm range. AFM images showed the topography of the pigments, which are related to the texture of their surface and thus to the production process. Finally, MFM showed different contrast regions suggesting the presence of ferromagnetic elements forming clusters and domain orientations on the color layer.

  9. Modeling and simulation of offshore wind farm O&M processes

    SciTech Connect

    Joschko, Philip; Widok, Andi H.; Appel, Susanne; Greiner, Saskia; Albers, Henning; Page, Bernd

    2015-04-15

    This paper describes a holistic approach to operation and maintenance (O&M) processes in the domain of offshore wind farm power generation. The acquisition and process visualization is followed by a risk analysis of all relevant processes. Hereafter, a tool was designed, which is able to model the defined processes in a BPMN 2.0 notation, as well as connect and simulate them. Furthermore, the notation was enriched with new elements, representing other relevant factors that were, to date, only displayable with much higher effort. In that regard a variety of more complex situations were integrated, such as for example new process interactions depending on different weather influences, in which case a stochastic weather generator was combined with the business simulation or other wind farm aspects important to the smooth running of the offshore wind farms. In addition, the choices for different methodologies, such as the simulation framework or the business process notation will be presented and elaborated depending on the impact they had on the development of the approach and the software solution. - Highlights: • Analysis of operation and maintenance processes of offshore wind farms • Process modeling with BPMN 2.0 • Domain-specific simulation tool.

  10. Effluent organic matter (EfOM) characterization by simultaneous measurement of proteins and humic matter.

    PubMed

    Vakondios, Nikos; Koukouraki, Elisavet E; Diamadopoulos, Evan

    2014-10-15

    This work developed a method, based on the Lowry method and Frølund modification, for the simultaneous determination of proteins and humic matter in wastewater effluent samples at low concentrations. The method was based on simultaneous spectrophotometric measurements of proteins and humic matter at 750 nm in the absence and presence of CuSO4, which is responsible for increasing the absorbance only in the presence of to proteins. Statistical analysis through ANOVA showed that the response surface of the method fit the experimental measurements at significance level lower than 0.05, indicating satisfactory fit. The quantification limits of the proposed method were 0.5-30 mg/l for proteins and 2-30 mg/l for humic matter. The presence of carbohydrates did not interfere with the analysis of proteins and humic matter at carbohydrate concentrations below 35-40 mg/l. The Lowry method overestimated the concentration of the proteins because of the presence of humic substances. A carbon balance indicated that the analytical method developed could provide a satisfactory distribution of the main organic constituents in wastewater and effluents.

  11. 78 FR 9961 - Self-Regulatory Organizations; NASDAQ OMS BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... posting Protected Quotations within the meaning of Regulation NMS (i.e. ``dark venues'' or ``dark pools... seek to execute on BX or on dark pools without executing on another exchange. Members may seek to....00- $10.01, and BX, DarkVenueA and ARCA each offer 100 shares at $10.01, a BDRK order to buy...

  12. RNA interference-based resistance in transgenic tomato plants against Tomato yellow leaf curl virus-Oman (TYLCV-OM) and its associated betasatellite.

    PubMed

    Ammara, Um e; Mansoor, Shahid; Saeed, Muhammad; Amin, Imran; Briddon, Rob W; Al-Sadi, Abdullah Mohammed

    2015-03-04

    Tomato yellow leaf curl virus (TYLCV), a monopartite begomovirus (family Geminiviridae) is responsible for heavy yield losses for tomato production around the globe. In Oman at least five distinct begomoviruses cause disease in tomato, including TYLCV. Unusually, TYLCV infections in Oman are sometimes associated with a betasatellite (Tomato leaf curl betasatellite [ToLCB]; a symptom modulating satellite). RNA interference (RNAi) can be used to develop resistance against begomoviruses at either the transcriptional or post-transcriptional levels. A hairpin RNAi (hpRNAi) construct to express double-stranded RNA homologous to sequences of the intergenic region, coat protein gene, V2 gene and replication-associated gene of Tomato yellow leaf curl virus-Oman (TYLCV-OM) was produced. Initially, transient expression of the hpRNAi construct at the site of virus inoculation was shown to reduce the number of plants developing symptoms when inoculated with either TYLCV-OM or TYLCV-OM with ToLCB-OM to Nicotiana benthamiana or tomato. Solanum lycopersicum L. cv. Pusa Ruby was transformed with the hpRNAi construct and nine confirmed transgenic lines were obtained and challenged with TYLCV-OM and ToLCB-OM by Agrobacterium-mediated inoculation. For all but one line, for which all plants remained symptomless, inoculation with TYLCV-OM led to a proportion (≤25%) of tomato plants developing symptoms of infection. For inoculation with TYLCV-OM and ToLCB-OM all lines showed a proportion of plants (≤45%) symptomatic. However, for all infected transgenic plants the symptoms were milder and virus titre in plants was lower than in infected non-transgenic tomato plants. These results show that RNAi can be used to develop resistance against geminiviruses in tomato. The resistance in this case is not immunity but does reduce the severity of infections and virus titer. Also, the betasatellite may compromise resistance, increasing the proportion of plants which ultimately show symptoms.

  13. Size-controlled synthesis and formation mechanism of manganese oxide OMS-2 nanowires under reflux conditions with KMnO4 and inorganic acids

    NASA Astrophysics Data System (ADS)

    Zhang, Qin; Cheng, Xiaodi; Qiu, Guohong; Liu, Fan; Feng, Xionghan

    2016-05-01

    This study presents a simplified approach for size-controlled synthesis of manganese oxide octahedral molecular sieve (OMS-2) nanowires using potassium permanganate (KMnO4) and different inorganic acids (HCl, HNO3, and H2SO4) under reflux conditions. The morphology and nanostructure of the synthesized products are characterized by X-ray diffraction, Ar adsorption, and electron microscopy analysis, in order to elucidate the controlling effects of acid concentration and type as well as the formation mechanism of OMS-2 nanowires. The concentration of inorganic acid is a crucial factor controlling the phase of the synthesized products. OMS-2 nanowires are obtained with HCl at the concentration ≥0.96 mol/L or with HNO3 and H2SO4 at the concentrations ≥0.72 mol/L. Differently, the type of inorganic acid effectively determines the particle size of OMS-2 nanowires. When the acid is changed from HCl to HNO3 and H2SO4 in the reflux system, the average length of OMS-2 declines significantly by 60-70% (1104-442 and 339 nm), with minor decreased in the average width (43-39 and 34 nm). The formation of OMS-2 nanowires under reflux conditions with KMnO4 and inorganic acids involves a two-step process, i.e., the initial formation of layered manganese oxides, and subsequent transformation to OMS-2 via a dissolution-recrystallization process under acidic conditions. The proposed reflux route provides an alternative approach for synthesizing OMS-2 nanowires as well as other porous nano-crystalline OMS materials.

  14. [Self-assessment of tasks and roles of occupational medicine service (OMS) nurses in the Polish system of workers' health protection].

    PubMed

    Sakowski, Piotr

    2010-01-01

    This paper presents the results of survey performed to find out how occupational medicine service (OMS) nurses assess their tasks and roles in the Polish system of workers' health protection. The survey was carried out in a random group of 200 OMS nurses. The survey showed that OMS nurses form-an experienced professional group. According to self-assessment they have an opportunity to use their competence in its full scope. Almost half of respondents agreed that in Poland the skills of OMS nurses are properly used. There are two reasons why certain tasks are not performed by OMS nurses, first, certain tasks are assigned to other persons in the unit; second, employers are sometimes not interested in those tasks or find them not necessary. The majority of nurses assess their knowledge and preparation to perform tasks relatively well, however they want to broaden their knowledge and improve their skills. OMS nurses play an important role in the Polish system of workers' health protection. They perform many tasks, which fall within the scope of OMS activities being currently implemented. Their competences are usually properly used. There is a need to convince employers that the scope of services provided by OMS units should be extended and adequately financed. This should result in the better use of OMS nurses' competences. Nurses are well educated and skilled to perform their jobs. Nevertheless, they feel the need to broaden their knowledge. Although the programs of specialization and qualification courses are rather comprehensive, nurses declare that some areas should be enriched with additional information.

  15. Badania Ekologiczne Ryzyka Zachorowań Na Kleszczowe Zapalenie Mózgu W Polsce-Omówienie Metody

    PubMed Central

    Stefanoff, Paweł; Staszewska, Ewa; Ustrnul, Zbigniew; Rogalska, Justyna; Łankiewicz, Aleksandra; Rosińska, Magdalena

    2009-01-01

    W pracy omówiono metodologię aktualnie prowadzonych badań ekologicznych kleszczowego zapalenia mózgu (kzm) na terenie Polski. W celu oceny wpływu zróżnicowanych czynników środowiskowych, klimatycznych oraz społecznych na występowanie kzm w różnych regionach Polski zostanie przeprowadzona wieloczynnikoica analiza statystyczna na poziomie gmin dla lat 1999-2006. PMID:22320045

  16. Combined use of SEM-EDS, OM and XRD for the characterization of corrosion products grown on silver roman coins

    NASA Astrophysics Data System (ADS)

    Ingo, G. M.; Balbi, S.; de Caro, T.; Fragalà, I.; Angelini, E.; Bultrini, G.

    2006-06-01

    In the framework of the PROMET project (European Commission contract No. 509126) aimed to develop new analytical techniques and materials for monitoring and protecting metal artefacts and monuments from the Mediterranean region, the corrosion products grown on silver Roman coins during archaeological burial is studied by means of scanning electron microscopy combined with energy dispersive spectrometry (SEM-EDS), X-ray diffraction (XRD) and optical microscopy (OM) techniques.

  17. Differentiating prescription omega-3-acid ethyl esters (P-OM3) from dietary-supplement omega-3 fatty acids.

    PubMed

    Brunton, Stephen; Collins, Nancy

    2007-05-01

    A reliable means of treating hyper-triglyceridemia is the use of large doses of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Modest levels of EPA and DHA may be obtained from food, particularly fatty fish. This article is intended to review clinically relevant differences between dietary-supplement omega-3 fatty acids and prescription omega-3-acid ethyl esters (P-OM3). PubMed and the Food and Drug Administration (FDA) Website were searched for articles published between 1995 and 2007 that contained the terms fish oil, fatty acids, n-3 fatty acids, omega fatty acids, docosahexaenoic acid, or eicosapentaenoic acid. Articles discussing sources, recommended intake, and differences among various formulations of omega-3 fatty acids were selected for review. A limitation to this review is the lack of head-to-head clinical trials using P-OM3 and dietary-supplement omega-3 fatty acids. Many types of nonprescription dietary supplements of omega-3 fatty acids are available; however, the efficacy, quality, and safety of these products are open to question because they are not regulated by the same standards as pharmaceutical agents. P-OM3 is the only omega-3 fatty acid product (Omacor capsules) approved by the US FDA available in the United States as an adjunct to diet to reduce very high (> or = 500 mg/dL) triglyceride levels in adult patients. P-OM3 can be used with confidence by practitioners who want to provide therapeutic doses of omega-3 fatty acids in a preparation that has been documented to be both safe and effective.

  18. Controlling the onset of OB/OM in a semiconductor quantum well system in an inverted Y-type configuration

    NASA Astrophysics Data System (ADS)

    Raheli, Ali; Hamedi, H. R.; Sahrai, M.

    2016-01-01

    The problem of optical bistability (OB) and optical multistability (OM) is numerically investigated in a four-level inverted Y-type semiconductor quantum well (SQW) structure immersed in a unidirectional ring cavity. In the four-level SQW system under consideration, a closed loop configuration is coupled to the upper level through a tunable probe field. We show that the OB threshold intensity can be controlled via the intensity of coupling fields which gives rise to the absorption variation of the probe field. In addition, due to the existence of the closed-loop configuration, the OB and OM behaviors of the proposed SQW medium are dependent on the relative phase of the applied fields. It is found that the OB can be switched to OM or vice versa by properly adjusting the relative phase of the applied fields. The results may provide new possibilities in real experiments for realizing an all-optical switching or coding element in a solid-state platform.

  19. The challenges of translating the clinical outcomes in Routine Evaluation-Outcome Measure (CORE-OM) into British Sign Language.

    PubMed

    Rogers, Katherine D; Young, Alys; Lovell, Karina; Evans, Chris

    2013-01-01

    This article discusses translation issues arising during the production of a British Sign Language (BSL) version of the psychological outcome measure "Clinical Outcomes in Routine Evaluation-Outcome Measure" (CORE-OM). The process included forward translation, meeting with a team of translators, producing a second draft of the BSL version and back translating into English. Further modifications were made to the BSL version before piloting it with d/Deaf populations. Details of the translation process are addressed, including (a) the implications of translating between modalities (written text to visual language); (b) clarity of frequency anchors: analog versus digital encoding; (c) pronouns and the direction of signing; and (iv) the influence of the on-screen format. The discussion of item-specific issues encountered when producing a BSL version of the CORE-OM includes the expression of precise emotional states in a language that uses visual modifiers, problems associated with iconic signs, and the influence of Deaf world knowledge when interpreting specific statements. Finally, it addresses the extent to which lessons learned through this translation process are generalizable to other signed languages and spoken language translations of standardized instruments. Despite the challenges, a BSL version of the CORE-OM has been produced and found to be reliable.

  20. 75 FR 16120 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... 4010, FR 4011, FR 4012, FR 4017, FR 4019, FR 4023, FR 4013, or FR 4014 by any of the following methods... Delegated Authority the Extension for Three Years, With Revision, of the Following Reports 1. Report title: Report of Selected Balance Sheet Items for Discount Window Borrowers. Agency form numbers: FR 2046. OMB...

  1. Enhanced Photocatalytic Degradation of Methyl Orange Dye under the Daylight Irradiation over CN-TiO2 Modified with OMS-2

    PubMed Central

    Hassan, Mohamed Elfatih; Chen, Jing; Liu, Guanglong; Zhu, Duanwei; Cai, Jianbo

    2014-01-01

    In this study, CN-TiO2 was modified with cryptomelane octahedral molecular sieves (OMS-2) by the sol-gel method based on the self-assembly technique to enhance its photocatalytic activity under the daylight irradiation. The synthesized samples were characterized by X-ray diffraction (XRD), UV-vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR) and porosimeter analysis. The results showed that the addition of OMS-2 in the sol lead to higher Brunauer-Emmett-Teller (BET) surface area, pore volume, porosity of particle after heat treatment and the specific surface area, porosity, crystallite size and pore size distribution could be controlled by adjusting the calcination temperature. Compared to the CN-TiO2-400 sample, CN-TiO2/OMS-2-400 exhibited greater red shift in absorption edge of samples in visible region due to the OMS-2 coated. The enhancement of photocatalytic activity of CN-TiO2/OMS-2 composite photocatalyst was subsequently evaluated for the degradation of the methyl orange dye under the daylight irradiation in water. The results showed that the methyl orange dye degradation rate reach to 37.8% for the CN-TiO2/OMS-2-400 sample under the daylight irradiation for 5 h, which was higher than that of reference sample. The enhancement in daylight photocatalytic activities of the CN-TiO2/OMS samples could be attributed to the synergistic effects of OMS-2 coated, larger surface area and red shift in adsorption edge of the prepared sample. PMID:28788288

  2. Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo

    PubMed Central

    Shin, Mi Hee; Park, Raeeun; Nojima, Hideo; Kim, Hyung-Chel; Kim, Yeon Kyung; Chung, Jin Ho

    2013-01-01

    Recently, there has been much effort to find effective ingredients which can prevent or retard cutaneous skin aging after topical or systemic use. Here, we investigated the effects of the atomic hydrogen surrounded by water molecules, H(H2O)m, on acute UV-induced responses and as well as skin aging. Interestingly, we observed that H(H2O)m application to human skin prevented UV-induced erythema and DNA damage. And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1β mRNA expressions in human skin in vivo. We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells. Next, we investigated the effects of H(H2O)m on intrinsically aged or photoaged skin of elderly subjects. In intrinsically aged skin, H(H2O)m application significantly reduced constitutive expressions of MMP-1, IL-6, and IL-1β mRNA. Additionally, H(H2O)m significantly increased procollagen mRNA and also decreased MMP-1 and IL-6 mRNA expressions in photoaged facial skin. These results demonstrated that local application of H(H2O)m may prevent UV-induced skin inflammation and can modulate intrinsic skin aging and photoaging processes. Therefore, we suggest that modifying the atmospheric gas environment within a room may be a new way to regulate skin functions or skin aging. PMID:23637886

  3. Kidney-specific chloride channel, OmClC-K, predominantly expressed in the diluting segment of freshwater-adapted tilapia kidney

    PubMed Central

    Miyazaki, Hiroaki; Kaneko, Toyoji; Uchida, Shinichi; Sasaki, Sei; Takei, Yoshio

    2002-01-01

    The kidney plays an important role in osmoregulation in freshwater teleosts, which are exposed to the danger of osmotic loss of Na+ and Cl−. However, ion-transport mechanisms in the kidney are poorly understood, and ion transporters of the fish nephron have not been identified thus far. From Mozambique tilapia, Oreochromis mossambicus, we have cloned a chloride channel, which is a homologue of the mammalian kidney-specific chloride channel, ClC-K. The cDNA of the channel, named OmClC-K, encodes a protein whose amino acid sequence has high homology to Xenopus and mammalian ClC-K (Xenopus ClC-K, 41.8%; rat ClC-K2, 40.9%; rat ClC-K1, 40.1%). The mRNA of OmClC-K was expressed exclusively in the kidney, and the expression level of mRNA was increased more in freshwater-adapted fish than seawater-adapted fish. The immunohistochemical study using a specific antibody showed that OmClC-K-positive cells were specifically located in the distal nephron segments. Immunoelectron microscopy further showed that immunoreaction of OmClC-K was recognizable on the structure of basolateral membrane infoldings in the distal tubule cells. The localization of OmClC-K and its induction in hypoosmotic media suggest that OmClC-K is involved in Cl− reabsorption in the distal tubule of freshwater-adapted tilapia. PMID:12427972

  4. Acute effects of 3G mobile phone radiations on frontal haemodynamics during a cognitive task in teenagers and possible protective value of Om chanting.

    PubMed

    Bhargav, Hemant; N K, Manjunath; Varambally, Shivarama; Mooventhan, A; Bista, Suman; Singh, Deepeshwar; Chhabra, Harleen; Venkatasubramanian, Ganesan; T M, Srinivasan; H R, Nagendra

    2016-06-01

    Mobile phone induced electromagnetic field (MPEMF) as well as chanting of Vedic mantra 'OM' has been shown to affect cognition and brain haemodynamics, but findings are still inconclusive. Twenty right-handed healthy teenagers (eight males and 12 females) in the age range of 18.25 ± 0.44 years were randomly divided into four groups: (1) MPONOM (mobile phone 'ON' followed by 'OM' chanting); (2) MPOFOM (mobile phone 'OFF' followed by 'OM' chanting); (3) MPONSS (mobile phone 'ON' followed by 'SS' chanting); and (4) MPOFSS (mobile phone 'OFF' followed by 'SS' chanting). Brain haemodynamics during Stroop task were recorded using a 64-channel fNIRS device at three points of time: (1) baseline, (2) after 30 min of MPON/OF exposure, and (3) after 5 min of OM/SS chanting. RM-ANOVA was applied to perform within- and between-group comparisons, respectively. Between-group analysis revealed that total scores on incongruent Stroop task were significantly better after OM as compared to SS chanting (MPOFOM vs MPOFSS), pre-frontal activation was significantly lesser after OM as compared to SS chanting in channel 13. There was no significant difference between MPON and MPOF conditions for Stroop performance, as well as brain haemodynamics. These findings need confirmation through a larger trial in future.

  5. Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element.

    PubMed Central

    Keul, R.; Roth, M.; Papakonstantinou, E.; Nauck, M.; Perruchoud, A. P.; Block, L. H.

    1996-01-01

    BACKGROUND: Broncho-Vaxom (OM-85 BV) increases the resistance of the respiratory tract to bacterial infections by modulating host immune responses. The compound increases serum IgG levels but decreases IgE levels in patients suffering from chronic bronchitis or chronic obstructive pulmonary disease. It increases concentrations of gamma-interferon (IFN-gamma), IgA, and interleukin (IL)-2 in bronchoalveolar lavage fluid of patients with bronchitis. Treatment with OM-85 BV increases the number of T helper and natural killer cells. In this study the effects of OM-85 BV on transcription of cytokines is investigated in human lung fibroblasts. METHODS: Transcription and synthesis of IL-6 and IL-8 were assessed in cultured primary human lung fibroblasts using standard methods of Northern blot analysis for the level of mRNAs and enzyme linked immunosorbent assay for proteins. RESULTS: Broncho-Vaxom (OM-85 BV) at different concentrations induced transcription of IL-6 and IL-8. The effect of the drug on transcription of IL-6 and IL-8 genes correlated with secretion of the proteins into cell supernatants. OM-85 BV-dependent expression of the interleukin genes involved C-Fos/serum responsive element (C-Fos/SRE). CONCLUSIONS: The data suggest that the various immunopharmacological activities of OM-85 BV that have been described in clinical studies may be explained by its ability to induce expression of IL-6 and IL-8. Images PMID:8711646

  6. Kidney-specific chloride channel, OmClC-K, predominantly expressed in the diluting segment of freshwater-adapted tilapia kidney.

    PubMed

    Miyazaki, Hiroaki; Kaneko, Toyoji; Uchida, Shinichi; Sasaki, Sei; Takei, Yoshio

    2002-11-26

    The kidney plays an important role in osmoregulation in freshwater teleosts, which are exposed to the danger of osmotic loss of Na(+) and Cl(-). However, ion-transport mechanisms in the kidney are poorly understood, and ion transporters of the fish nephron have not been identified thus far. From Mozambique tilapia, Oreochromis mossambicus, we have cloned a chloride channel, which is a homologue of the mammalian kidney-specific chloride channel, ClC-K. The cDNA of the channel, named OmClC-K, encodes a protein whose amino acid sequence has high homology to Xenopus and mammalian ClC-K (Xenopus ClC-K, 41.8%; rat ClC-K2, 40.9%; rat ClC-K1, 40.1%). The mRNA of OmClC-K was expressed exclusively in the kidney, and the expression level of mRNA was increased more in freshwater-adapted fish than seawater-adapted fish. The immunohistochemical study using a specific antibody showed that OmClC-K-positive cells were specifically located in the distal nephron segments. Immunoelectron microscopy further showed that immunoreaction of OmClC-K was recognizable on the structure of basolateral membrane infoldings in the distal tubule cells. The localization of OmClC-K and its induction in hypoosmotic media suggest that OmClC-K is involved in Cl(-) reabsorption in the distal tubule of freshwater-adapted tilapia.

  7. 78 FR 32387 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... 4010, FR 4011, FR 4012, FR 4017, FR 4019, or FR 4023 by any of the following methods: Agency Web Site... curing the deficiencies and to execute a formal cure agreement with the Federal Reserve.\\5\\ \\4\\ 12...

  8. Estimating a Preference-Based Index from the Clinical Outcomes in Routine Evaluation–Outcome Measure (CORE-OM)

    PubMed Central

    Brazier, John E.; Rowen, Donna; Barkham, Michael

    2013-01-01

    Background. The Clinical Outcomes in Routine Evaluation–Outcome Measure (CORE-OM) is used to evaluate the effectiveness of psychological therapies in people with common mental disorders. The objective of this study was to estimate a preference-based index for this population using CORE-6D, a health state classification system derived from the CORE-OM consisting of a 5-item emotional component and a physical item, and to demonstrate a novel method for generating states that are not orthogonal. Methods. Rasch analysis was used to identify 11 emotional health states from CORE-6D that were frequently observed in the study population and are, thus, plausible (in contrast, conventional statistical design might generate implausible states). Combined with the 3 response levels of the physical item of CORE-6D, they generate 33 plausible health states, 18 of which were selected for valuation. A valuation survey of 220 members of the public in South Yorkshire, United Kingdom, was undertaken using the time tradeoff (TTO) method. Regression analysis was subsequently used to predict values for all possible states described by CORE-6D. Results. A number of multivariate regression models were built to predict values for the 33 health states of CORE-6D, using the Rasch logit value of the emotional state and the response level of the physical item as independent variables. A cubic model with high predictive value (adjusted R2 = 0.990) was selected to predict TTO values for all 729 CORE-6D health states. Conclusion. The CORE-6D preference-based index will enable the assessment of cost-effectiveness of interventions for people with common mental disorders using existing and prospective CORE-OM data sets. The new method for generating states may be useful for other instruments with highly correlated dimensions. PMID:23178639

  9. What a Shame: Increased Rates of OMS Resident Burnout May Be Related to the Frequency of Shamed Events During Training.

    PubMed

    Shapiro, Michael C; Rao, Sowmya R; Dean, Jason; Salama, Andrew R

    2017-03-01

    Shame is an ineffective tool in residency education that often results in depression, isolation, and worse patient care. This study aimed to assess burnout, depersonalization, and personal achievement levels in current oral and maxillofacial surgery (OMS) residents, to assess the prevalence of the use of shame in OMS residency training, and to determine whether there is a relation between shame exposure and resident burnout, depersonalization, and personal achievement levels. An anonymous 20-question cross-sectional survey was developed incorporating the Maslach Burnout Index and a previously validated shame questionnaire and sent to all OMS program directors affiliated with the American Association of Oral and Maxillofacial Surgeons for distribution among their respective residents in 2016. Univariate analyses were used to determine the distribution of the predictor (shame) and outcome (burnout) by gender and by frequency of shaming events. Multivariable logistic regression analysis was used to assess the relation of shame to burnout. A 2-sided P value less than .05 was considered statistically significant. Two hundred seventeen responses were received; 82% of respondents were men (n = 178), 95% were 25 to 34 years old (n = 206), and 58% (n = 126) were enrolled in a 4-year program. Frequently shamed residents were more likely to have depression (58 vs 22%; P < .0001), isolation (55 vs 22%; P < .0001), and poor job performance (50 vs 30%; P < .0001). Residents who were frequently shamed were more likely to experience moderate to severe burnout (odds ratio = 4.6; 95% confidence interval, 2.1-10.0; P < .001) and severe depersonalization (odds ratio = 5.1; 95% confidence interval, 2.1-12.0; P < .0001) than residents who had never or infrequently been shamed. There is a clear relation between the number of shame events and burnout and depersonalization levels. It is important to understand the negative impact that the experience of shame has on residents

  10. Intracameral phenylephrine and ketorolac injection (OMS302) for maintenance of intraoperative pupil diameter and reduction of postoperative pain in intraocular lens replacement with phacoemulsification

    PubMed Central

    Lindstrom, Richard L; Loden, James C; Walters, Thomas R; Dunn, Steven H; Whitaker, J Steven; Kim, Terry; Demopulos, Gregory A; Tjia, Khiun

    2014-01-01

    Background The purpose of this study was to evaluate the effect of OMS302 on intraoperative pupil diameter and early postoperative ocular pain when administered during intraocular lens replacement surgery. Methods Four hundred and six patients (406 study eyes; 202 in the OMS302 group and 204 in the placebo group) were entered into this randomized, double-masked, placebo-controlled, multicenter Phase III study, which was conducted at 15 centers in the USA and the Netherlands. The patients received OMS302 (60.75 mM phenylephrine HCl and 11.25 mM ketorolac tromethamine) or placebo in irrigation solution during intraocular lens replacement. No other changes in procedure were required. Coprimary endpoints were change in pupil diameter over time from surgical baseline to end of procedure and patient-reported ocular pain during the first 12 hours postoperatively. Secondary endpoints included additional measures of pupil diameter and postoperative pain. Results OMS302 was superior to placebo in maintaining intraoperative mydriasis, preventing miosis, and reducing postoperative pain. The weighted mean (standard error) difference (OMS302 – placebo) in change in the area under the curve from baseline for pupil diameter was 0.590 ([0.049]; 95% confidence interval 0.494 to 0.686; P<0.0001). For ocular pain scores, the weighted mean (standard error) difference was −4.580 ([1.192]; 95% confidence interval −6.917 to 2.244; P=0.0002). All secondary efficacy results favored OMS302. Specifically, analyses supporting prevention of miosis (patients with ≥6 mm pupil diameter at completion of cortical clean-up and those with <6 mm diameter at any time during surgery) were significant for OMS302 (95.9% versus 77.0% and 9.2% versus 38.0%, respectively; P<0.0001 for each endpoint). OMS302 was well tolerated and not associated with any unexpected adverse events. Conclusion OMS302 maintained mydriasis, prevented miosis, and reduced early postoperative pain when administered in

  11. Opening Minds Stigma Scale for Health Care Providers (OMS-HC): Examination of psychometric properties and responsiveness

    PubMed Central

    2014-01-01

    Background Diminishing stigmatization for those with mental illnesses by health care providers (HCPs) is becoming a priority for programming and policy, as well as research. In order to be successful, we must accurately measure stigmatizing attitudes and behaviours among HCPs. The Opening Minds Stigma Scale for Health Care Providers (OMS-HC) was developed to measure stigma in HCP populations. In this study we revisit the factor structure and the responsiveness of the OMS-HC in a larger, more representative sample of HCPs that are more likely to be targets for anti-stigma interventions. Methods Baseline data were collected from HCPs (n = 1,523) during 12 different anti-stigma interventions across Canada. The majority of HCPs were women (77.4%) and were either physicians (MDs) (41.5%), nurses (17.0%), medical students (13.4%), or students in allied health programs (14.0%). Exploratory factor analysis (EFA) was conducted using complete pre-test (n = 1,305) survey data and responsiveness to change analyses was examined with pre and post matched data (n = 803). The internal consistency of the OMS-HC scale and subscales was evaluated using the Cronbach’s alpha coefficient. The scale’s sensitivity to change was examined using paired t-tests, effect sizes (Cohen’s d), and standardized response means (SRM). Results The EFA favored a 3-factor structure which accounted for 45.3% of the variance using 15 of 20 items. The overall internal consistency for the 15-item scale (α = 0.79) and three subscales (α = 0.67 to 0.68) was acceptable. Subgroup analysis showed the internal consistency was satisfactory across HCP groups including physicians and nurses (α = 0.66 to 0.78). Evidence for the scale’s responsiveness to change occurred across multiple samples, including student-targeted interventions and workshops for practicing HCPs. The Social Distance subscale had the weakest level of responsiveness (SRM ≤ 0.50) whereas the more attitudinal

  12. Opening Minds Stigma Scale for Health Care Providers (OMS-HC): examination of psychometric properties and responsiveness.

    PubMed

    Modgill, Geeta; Patten, Scott B; Knaak, Stephanie; Kassam, Aliya; Szeto, Andrew C H

    2014-04-23

    Diminishing stigmatization for those with mental illnesses by health care providers (HCPs) is becoming a priority for programming and policy, as well as research. In order to be successful, we must accurately measure stigmatizing attitudes and behaviours among HCPs. The Opening Minds Stigma Scale for Health Care Providers (OMS-HC) was developed to measure stigma in HCP populations. In this study we revisit the factor structure and the responsiveness of the OMS-HC in a larger, more representative sample of HCPs that are more likely to be targets for anti-stigma interventions. Baseline data were collected from HCPs (n = 1,523) during 12 different anti-stigma interventions across Canada. The majority of HCPs were women (77.4%) and were either physicians (MDs) (41.5%), nurses (17.0%), medical students (13.4%), or students in allied health programs (14.0%). Exploratory factor analysis (EFA) was conducted using complete pre-test (n = 1,305) survey data and responsiveness to change analyses was examined with pre and post matched data (n = 803). The internal consistency of the OMS-HC scale and subscales was evaluated using the Cronbach's alpha coefficient. The scale's sensitivity to change was examined using paired t-tests, effect sizes (Cohen's d), and standardized response means (SRM). The EFA favored a 3-factor structure which accounted for 45.3% of the variance using 15 of 20 items. The overall internal consistency for the 15-item scale (α = 0.79) and three subscales (α = 0.67 to 0.68) was acceptable. Subgroup analysis showed the internal consistency was satisfactory across HCP groups including physicians and nurses (α = 0.66 to 0.78). Evidence for the scale's responsiveness to change occurred across multiple samples, including student-targeted interventions and workshops for practicing HCPs. The Social Distance subscale had the weakest level of responsiveness (SRM ≤ 0.50) whereas the more attitudinal-based items comprising the Attitude

  13. High efficiency epitaxial GaAs/GaAs and GaAs/Ge solar cell technology using OM/CVD

    NASA Technical Reports Server (NTRS)

    Wang, K. L.; Yeh, Y. C. M.; Stirn, R. J.; Swerdling, S.

    1980-01-01

    A technology for fabricating high efficiency, thin film GaAs solar cells on substrates appropriate for space and/or terrestrial applications was developed. The approach adopted utilizes organometallic chemical vapor deposition (OM-CVD) to form a GaAs layer epitaxially on a suitably prepared Ge epi-interlayer deposited on a substrate, especially a light weight silicon substrate which can lead to a 300 watt per kilogram array technology for space. The proposed cell structure is described. The GaAs epilayer growth on single crystal GaAs and Ge wafer substrates were investigated.

  14. Millimetre-scale spatial distribution of stable OM components at intact preferential flow path surfaces in the B-horizon of two Luvisols

    NASA Astrophysics Data System (ADS)

    Leue, Martin; Ellerbrock, Ruth H.; Gerke, Horst H.

    2015-04-01

    In structured soils, the interaction of percolating water and reactive solutes with the soil matrix is often restricted to surfaces of preferential flow paths. In the subsoil horizons of Luvisols, surfaces of biopores and aggregates can be enriched in clay and organic matter (OM). These coatings not only contribute to the OM stabilization in subsoil horizons but the OM composition of the coatings also determines the bio-physico-chemical surface properties which are relevant during rapid solute transport. Using a combined approach of Fourier transform infrared spectroscopy in diffuse reflectance mode (DRIFT) and pyrolysis-field ionization mass spectrometry (Py-FIMS), the OM composition of standardized (i.e., diluted and ground) samples separated from soil aggregate coatings was found to be enriched in chemically stable OM components. However, it remained unclear if these results could be verified for intact samples. The objective of this study was to analyse the mm-scale distribution of stable OM components at intact structural surfaces of two Luvisols based on DRIFT mapping and correlations between DRIFT spectra and Py-FI mass spectra. Samples were manually separated from the outermost surfaces of earthworm burrows, coated and uncoated cracks, root channels, and pinhole fillings of the B-horizons of Luvisols developed from loess and glacial till. The DRIFT spectra of these undiluted and particle-intact samples were interpreted by the help of Py-FIMS data to identify spectral regions representative of functional groups of chemically stable (i.e., recalcitrant) OM components. The DRIFT mapping technique was applied to determine OM functional group data (i.e., C=C and C=O signals) from stable OM components at the intact structural surface types in mm-scale transects and grids. The DRIFT signal intensities from C=O and C=C bonds in the infrared range of wave number 1688 … 1565 cm-1 were related to highly stable, chemically recalcitrant OM components, examined by Py

  15. Ordered micro/macro porous K-OMS-2/SiO2 nanocatalysts: Facile synthesis, low cost and high catalytic activity for diesel soot combustion

    PubMed Central

    Yu, Xuehua; Zhao, Zhen; Wei, Yuechang; Liu, Jian

    2017-01-01

    A series of novel oxide catalysts, which contain three-dimensionally ordered macroporous (3DOM) and microporous structure, were firstly designed and successfully synthesized by simple method. In the as-prepared catalysts, 3DOM SiO2 is used as support and microporous K-OMS-2 oxide nanoparticles are supported on the wall of SiO2. 3DOM K-OMS-2/SiO2 oxide catalysts were firstly used in soot particle oxidation reaction and they show very high catalytic activities. The high activities of K-OMS-2/SiO2 oxide catalysts can be assigned to three possible reasons: macroporous effect of 3DOM structure for improving contact between soot and catalyst, microporous effect of K-OMS-2 for adsorption of small gas molecules and interaction of K and Mn for activation of gas molecules. The catalytic activities of catalysts are comparable to or even higher than noble metal catalyst in the medium and high temperature range. For example, the T50 of K-OMS-2/SiO2-50, 328 °C, is much lower than those of Pt/Al2O3 and 3DOM Au/LaFeO3, 464 and 356 °C,respectively. Moreover, catalysts exhibited high catalytic stability. It is attributed to that the K+ ions are introduced into the microporous structure of OMS-2 and stabilized in the catalytic reaction. Meanwhile, the K+ ions play an important role in templating and stabilizing the tunneled framework of OMS-2. PMID:28443610

  16. Ordered micro/macro porous K-OMS-2/SiO2 nanocatalysts: Facile synthesis, low cost and high catalytic activity for diesel soot combustion.

    PubMed

    Yu, Xuehua; Zhao, Zhen; Wei, Yuechang; Liu, Jian

    2017-04-26

    A series of novel oxide catalysts, which contain three-dimensionally ordered macroporous (3DOM) and microporous structure, were firstly designed and successfully synthesized by simple method. In the as-prepared catalysts, 3DOM SiO2 is used as support and microporous K-OMS-2 oxide nanoparticles are supported on the wall of SiO2. 3DOM K-OMS-2/SiO2 oxide catalysts were firstly used in soot particle oxidation reaction and they show very high catalytic activities. The high activities of K-OMS-2/SiO2 oxide catalysts can be assigned to three possible reasons: macroporous effect of 3DOM structure for improving contact between soot and catalyst, microporous effect of K-OMS-2 for adsorption of small gas molecules and interaction of K and Mn for activation of gas molecules. The catalytic activities of catalysts are comparable to or even higher than noble metal catalyst in the medium and high temperature range. For example, the T50 of K-OMS-2/SiO2-50, 328 °C, is much lower than those of Pt/Al2O3 and 3DOM Au/LaFeO3, 464 and 356 °C,respectively. Moreover, catalysts exhibited high catalytic stability. It is attributed to that the K(+) ions are introduced into the microporous structure of OMS-2 and stabilized in the catalytic reaction. Meanwhile, the K(+) ions play an important role in templating and stabilizing the tunneled framework of OMS-2.

  17. Ordered micro/macro porous K-OMS-2/SiO2 nanocatalysts: Facile synthesis, low cost and high catalytic activity for diesel soot combustion

    NASA Astrophysics Data System (ADS)

    Yu, Xuehua; Zhao, Zhen; Wei, Yuechang; Liu, Jian

    2017-04-01

    A series of novel oxide catalysts, which contain three-dimensionally ordered macroporous (3DOM) and microporous structure, were firstly designed and successfully synthesized by simple method. In the as-prepared catalysts, 3DOM SiO2 is used as support and microporous K-OMS-2 oxide nanoparticles are supported on the wall of SiO2. 3DOM K-OMS-2/SiO2 oxide catalysts were firstly used in soot particle oxidation reaction and they show very high catalytic activities. The high activities of K-OMS-2/SiO2 oxide catalysts can be assigned to three possible reasons: macroporous effect of 3DOM structure for improving contact between soot and catalyst, microporous effect of K-OMS-2 for adsorption of small gas molecules and interaction of K and Mn for activation of gas molecules. The catalytic activities of catalysts are comparable to or even higher than noble metal catalyst in the medium and high temperature range. For example, the T50 of K-OMS-2/SiO2-50, 328 °C, is much lower than those of Pt/Al2O3 and 3DOM Au/LaFeO3, 464 and 356 °C,respectively. Moreover, catalysts exhibited high catalytic stability. It is attributed to that the K+ ions are introduced into the microporous structure of OMS-2 and stabilized in the catalytic reaction. Meanwhile, the K+ ions play an important role in templating and stabilizing the tunneled framework of OMS-2.

  18. Ir Spectroscopy Study on the (HCl)N(H2O)M Aggregation in Helium Nanodroplets

    NASA Astrophysics Data System (ADS)

    Nieto, Pablo; Letzner, Melanie; Habig, Daniel; Poerschke, Toersten; Grün, Sarah Angelique; Hanke, Kenny; Schwaab, Gerhard; Havenith, Martina

    2011-06-01

    The study of acid-water clusters is an active area of research due to its fundamental importance for chemistry. In particular the (HCl)N(H2O)M clusters have been extensively investigated both theoretically and experimentally as a benchmark system. Despite of the great effort devoted to its understanding HCl dissociation in water clusters is still not well understood. An IR-Spectroscopy study on (HCl)N(H2O)M embedded in helium nanodroplets will be presented. The H216O→H218O and isotopic substitution was used in the experiments to probe the bands in the 2650-2760 Cm-1 spectral range which has been object of some debate recently. The observed isotopic shifts for the different bands raise some new questions to be addressed. D. Marx, Chem. Phys. Chem. 7, 1848, (2006). V. E. Bondybey et al., Int. Rev. Phys. Chem. 21, 277 (2002). A. Gutberlet et al., Science 324, 1545 (2009). S. D. Flynn et al., Phys. Chem. Lett. 1, 2233 (2010).

  19. Linking wood source and charring temperature to the stability and biological reactivity of PyOM in a temperate forest soil.

    NASA Astrophysics Data System (ADS)

    Gibson, Christy; Filley, Timothy; Hatton, Pierre Joseph; Nadelhoffer, Knute; Stark, Ruth; Bird, Jeffrey

    2015-04-01

    Fire is a major mediator of carbon (C) and nitrogen (N) cycling in forests, releasing significant quantities of greenhouse gases, soot, and aerosols while simultaneously depositing pyrogenic organic matter (PyOM) onto forest soil. The condensed aromatic structure of PyOM imparts a resistance to weathering and decay and potentially promotes soil C stabilization and sequestration. This resistance however, is largely dependent upon the physiochemical characteristics of source material and production temperature. Few studies have been able to determine the stability and reactivity of well-characterized PyOM in field or laboratory decay studies. To address this, we added highly 13C-enriched red maple (RM) or jack pine (JP) pyrolyzed at 200, 300, 450 or 600°C to a low C, near-surface soil (0.5%; 0-20 cm-depth) at 60% water holding capacity and 11% of native soil C. We then incubated the samples in the dark at 25°C for 6 months. The results of 13CO2 evolution measurements indicated that both pyrolysis temperature and wood species played a significant role in PyOM mineralization. PyOM mineralization rates decreased with increasing pyrolysis temperature for either species. RM mineralization rates were consistently greater (~5 to ~25%) than for JP <600°C during the first 17 days, but declined after this time point with the exception of RM PyOM 300°C and 450°C, which had higher mineralization rates than JP throughout the entire incubation period. These observations of relative reactivity were consistent with our detailed spectroscopic, elemental, and stable isotope analysis of the PyOM samples across this pyrolysis gradient, which shows significant physicochemical changes happening more readily for JP (~300°C) than for RM (450°C). These results highlight how differences in PyOM physiochemical characteristics linked to wood species thermal transformation thresholds may be predictors in determining the relative stability of PyOM in soil.

  20. Tuning the K+ concentration in the tunnel of OMS-2 nanorods leads to a significant enhancement of the catalytic activity for benzene oxidation.

    PubMed

    Hou, Jingtao; Liu, Liangliang; Li, Yuanzhi; Mao, Mingyang; Lv, Haiqin; Zhao, Xiujian

    2013-12-03

    OMS-2 nanorods with tunable K(+) concentration were prepared by a facile hydrothermal redox reaction of MnSO4, (NH4)2S2O8, and (NH4)2SO4 at 120 °C by adding KNO3 at different KNO3/MnSO4 molar ratios. The OMS-2 nanorod catalysts are characterized by X-ray diffraction, transmission electron microscopy, N2 adsorption and desorption, inductively coupled plasma, and X-ray photoelectron spectrometry. The effect of K(+) concentration on the lattice oxygen activity of OMS-2 is theoretically and experimentally studied by density functional theory calculations and CO temperature-programmed reduction. The results show that increasing the K(+) concentration leads to a considerable enhancement of the lattice oxygen activity in OMS-2 nanorods. An enormous decrease (ΔT50 = 89 °C; ΔT90 > 160 °C) in reaction temperatures T50 and T90 (corresponding to 50 and 90% benzene conversion, respectively) for benzene oxidation has been achieved by increasing the K(+) concentration in the K(+)-doped OMS-2 nanorods due to the considerable enhancement of the lattice oxygen activity.

  1. Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mouse.

    PubMed Central

    Pardo-Manuel De Villena, F; de La Casa-Esperón, E; Williams, J W; Malette, J M; Rosa, M; Sapienza, C

    2000-01-01

    Matings between (C57BL/6 x DDK)F(1) females and C57BL/6 males result in a significant excess of offspring inheriting maternal DDK alleles in the central region of mouse chromosome 11 due to meiotic drive at the second meiotic division. We have shown previously that the locus subject to selection is in the vicinity of D11Mit66, a marker closely linked to the Om locus that controls the preimplantation embryo-lethal phenotype known as the "DDK syndrome." We have also shown that observation of meiotic drive in this system depends upon the genotype of the sire. Here we show that females that are heterozygous at Om retain the meiotic drive phenotype and define a 0.32-cM candidate interval for the Responder locus in this drive system. In addition, analysis of the inheritance of alleles at Om among the offspring of F(1) intercrosses indicates that the effect of the sire is determined by the sperm genotype at Om or a locus linked to Om. PMID:10790402

  2. Transmission-ratio distortion through F{sub 1} females at chromosome 11 loci linked to Om in the mouse DDK syndrome

    SciTech Connect

    Villena, F.P.M. de; Naumova, A.K.; Smith, M.; Verner, A.

    1996-04-01

    We determined the genotypes of >200 offspring that are survivors of matings between female reciprocal F{sub 1} hybrids (between the DDK and C57BL/6J inbred mouse strains) and C57BL/6J males at markers linked to the Ovum mutant (Om) locus on chromosome 11. In contrast to the expectations of our previous genetic model to explain the {open_quotes}DDK syndrome,{close_quotes} the genotypes of these offspring do not reflect preferential survival of individuals that receive C57BL/6J alleles from the F{sub 1} females in the region of chromosome 11 to which the Om locus has been mapped. In face, we observe significant transmission-ratio distortion in favor of DDK alleles in this region. These results are also in contrast to the expectation of Wakasugi`s genetic model for the inheritance of Om, in which he proposed equal transmission of DDK and non-DDK alleles from F{sub 1} females. We propose that the results of these experiments may be explained by reduced expression of the maternal DDK Om allele or expression of the maternal DDK Om allele in only a portion of the ova of F{sub 1} females. 23 refs., 2 figs., 2 tabs.

  3. Effect of anoxic vs. oxic conditions in soils on composition of mobile OM as revealed from comprehensive fluorescence analysis of soil effluents

    NASA Astrophysics Data System (ADS)

    Fritzsche, Andreas; Ritschel, Thomas; Totsche, Kai

    2014-05-01

    The fractionation of OM due to sorption of DOM on mineral surfaces has drawn much attention in soil science. This is mainly motivated by the implied stabilization of OM and the disposition of less affine organic molecules as mobile compounds within porous media, both processes significantly affecting the carbon cycling and that of OM-associated elements. In this study, we provide a time-resolved assessment of mobile OM in soil effluents on the basis of fluorescence excitation-emission-matrices (EEM). Our comprehensive fluorescence EEM analysis was based on a supervised parallel factor analysis (PARAFAC) that permits the fixing of selected components. We estimated the protein content in soil effluent OM with a reference for microbially produced proteins from Bacillus subtilis. The soil effluent was obtained from soil columns filled with topsoil either from a floodplain site or a maize field. Except for the 1 mM NaCl influent, nothing was added to the soil columns. Under water-saturated conditions, the activity of autochthonous microbial communities induced anoxic conditions within the soil columns resulting in the microbial reduction of pedogenic Fe(III) oxides and subsequent discharge of mobile Fe2+ during percolation. Upon re-aeration of the soil effluent, Fe2+ re-oxidized and precipitated as organo-mineral ferrihydrite in the soil effluent. EEM from consecutively sampled effluent fractions pointed to a mainly invariant soil effluent OM composition, where fulvic acid-like components were predominant. However, the OM, which was associated with the effluent ferrihydrite, was enriched in proteins, which was confirmed by corresponding FTIR spectra. This suggests the preferential association of proteins with in situ-precipitated ferrihydrite, rendering proteins less mobile in soils, where precipitation and immobilization of ferrihydrite occurs. Consequently, one would assume lower protein concentrations in the soil effluent if ferrihydrite precipitation occurs within

  4. Understanding the fouling of UF/MF hollow fibres of biologically treated wastewaters using advanced EfOM characterization and statistical tools.

    PubMed

    Filloux, E; Labanowski, J; Croue, J P

    2012-08-01

    Five secondary effluents and a river water source were characterized using size exclusion chromatography (LC-OCD-UVD-OND) and emission-excitation matrix (EEM) fluorescence spectroscopy in order to identify the major effluent organic matter (EfOM) fractions responsible for membrane fouling. This study showed the feasibility of coupling fluorescence EEM and LC-OCD-UVD-OND to investigate the fouling potential as well as a means to differentiate natural organic matter (NOM) from EfOM. The secondary effluents and river water showed a significant difference in organic matter characteristics and fouling potential, highlighting the importance of biological processes and the feed water source on EfOM characteristics and fouling potential. On the basis of statistical analysis, protein-like substances were found to be highly correlated to the fouling potential of secondary effluents. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. Brazilian Portuguese version of the CORE-OM: cross-cultural adaptation of an instrument to assess the efficacy and effectiveness of psychotherapy.

    PubMed

    Santana, Márcia Rosane Moreira; da Silva, Marília Marques; de Moraes, Danielle Souza; Fukuda, Cláudia Cristina; Freitas, Lucia Helena; Ramos, Maria Eveline Cascardo; Fleury, Heloísa Junqueira; Evans, Chris

    2015-01-01

    The Clinical Outcome in Routine Evaluation - Outcome Measurement (CORE-OM) was developed in the 1990s, with the aim of assessing the efficacy and effectiveness of mental health treatments. To adapt the CORE-OM for use in the Brazilian population. The instrument was translated and adapted based on the international protocol developed by the CORE System Trust which contains seven steps: translation, semantic equivalence analysis, synthesis of the translated versions, pre-testing in the target population, data analysis and back translation. After semantic analysis, modifications were necessary in seven of the 34 original items. Changes were made to avoid repetition of words and the use of terms difficult to understand. Internal consistency analysis showed evidence of score stability in the CORE-OM adapted to Brazilian Portuguese. The instrument was successfully adapted to Brazilian Portuguese, and its semantic and conceptual properties were equivalent to those of the original instrument.

  6. Identification of TL-Om1, an Adult T-Cell Leukemia (ATL) Cell Line, as Reference Material for Quantitative PCR for Human T-Lymphotropic Virus 1

    PubMed Central

    Okuma, Kazu; Yamagishi, Makoto; Yamochi, Tadanori; Firouzi, Sanaz; Momose, Haruka; Mizukami, Takuo; Takizawa, Kazuya; Araki, Kumiko; Sugamura, Kazuo; Yamaguchi, Kazunari; Watanabe, Toshiki

    2014-01-01

    Quantitative PCR (qPCR) for human T-lymphotropic virus 1 (HTLV-1) is useful for measuring the amount of integrated HTLV-1 proviral DNA in peripheral blood mononuclear cells. Many laboratories in Japan have developed different HTLV-1 qPCR methods. However, when six independent laboratories analyzed the proviral load of the same samples, there was a 5-fold difference in their results. To standardize HTLV-1 qPCR, preparation of a well-defined reference material is needed. We analyzed the integrated HTLV-1 genome and the internal control (IC) genes of TL-Om1, a cell line derived from adult T-cell leukemia, to confirm its suitability as a reference material for HTLV-1 qPCR. Fluorescent in situ hybridization (FISH) showed that HTLV-1 provirus was monoclonally integrated in chromosome 1 at the site of 1p13 in the TL-Om1 genome. HTLV-1 proviral genome was not transferred from TL-Om1 to an uninfected T-cell line, suggesting that the HTLV-1 proviral copy number in TL-Om1 cells is stable. To determine the copy number of HTLV-1 provirus and IC genes in TL-Om1 cells, we used FISH, digital PCR, and qPCR. HTLV-1 copy numbers obtained by these three methods were similar, suggesting that their results were accurate. Also, the ratio of the copy number of HTLV-1 provirus to one of the IC genes, RNase P, was consistent for all three methods. These findings indicate that TL-Om1 cells are an appropriate reference material for HTLV-1 qPCR. PMID:25502533

  7. Identification of TL-Om1, an adult T-cell leukemia (ATL) cell line, as reference material for quantitative PCR for human T-lymphotropic virus 1.

    PubMed

    Kuramitsu, Madoka; Okuma, Kazu; Yamagishi, Makoto; Yamochi, Tadanori; Firouzi, Sanaz; Momose, Haruka; Mizukami, Takuo; Takizawa, Kazuya; Araki, Kumiko; Sugamura, Kazuo; Yamaguchi, Kazunari; Watanabe, Toshiki; Hamaguchi, Isao

    2015-02-01

    Quantitative PCR (qPCR) for human T-lymphotropic virus 1 (HTLV-1) is useful for measuring the amount of integrated HTLV-1 proviral DNA in peripheral blood mononuclear cells. Many laboratories in Japan have developed different HTLV-1 qPCR methods. However, when six independent laboratories analyzed the proviral load of the same samples, there was a 5-fold difference in their results. To standardize HTLV-1 qPCR, preparation of a well-defined reference material is needed. We analyzed the integrated HTLV-1 genome and the internal control (IC) genes of TL-Om1, a cell line derived from adult T-cell leukemia, to confirm its suitability as a reference material for HTLV-1 qPCR. Fluorescent in situ hybridization (FISH) showed that HTLV-1 provirus was monoclonally integrated in chromosome 1 at the site of 1p13 in the TL-Om1 genome. HTLV-1 proviral genome was not transferred from TL-Om1 to an uninfected T-cell line, suggesting that the HTLV-1 proviral copy number in TL-Om1 cells is stable. To determine the copy number of HTLV-1 provirus and IC genes in TL-Om1 cells, we used FISH, digital PCR, and qPCR. HTLV-1 copy numbers obtained by these three methods were similar, suggesting that their results were accurate. Also, the ratio of the copy number of HTLV-1 provirus to one of the IC genes, RNase P, was consistent for all three methods. These findings indicate that TL-Om1 cells are an appropriate reference material for HTLV-1 qPCR. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  8. OmGOGAT-disruption in the ericoid mycorrhizal fungus Oidiodendron maius induces reorganization of the N pathway and reduces tolerance to heavy-metals.

    PubMed

    Khouja, H R; Daghino, S; Abbà, S; Boutaraa, F; Chalot, M; Blaudez, D; Martino, E; Perotto, S

    2014-10-01

    Mycorrhizal fungi are key mediators of soil-to-plant movement of mineral nutrients, including essential and non-essential metals. In soil conditions that facilitate mobilization of metal ions, potentially toxic metals can interfere with nitrogen metabolism in both plants and microorganisms. Less is known about possible relationships between nitrogen metabolism and responses to heavy metals. Aim of this study was to investigate this aspect in the ericoid mycorrhizal fungus Oidiodendron maius strain Zn, a metal tolerant ascomycete. Growth of O. maius Zn on zinc and cadmium containing media was significantly affected by the nitrogen source. Screening of a library of O. maius Zn random genetic transformants for sensitivity to heavy metals (zinc and cadmium) and oxidative stress (menadione) yielded a mutant strain that carried a partial deletion of the glutamate synthase (NADH-GOGAT EC 1.4.1.14) gene and its adjacent gene, the APC15 subunit of the anaphase promoting complex. Comparison of WT and OmGOGAT-OmAPC15 mutant strains indicated an impaired N-metabolism and altered stress tolerance, and assays on the OmAPC15-recomplemented strains ascribed the observed phenotypes to the deletion in the OmGOGAT gene. OmGOGAT disruption modified the nitrogen pathway, with a strong reduction of the associated glutamine synthetase (GS, EC 6.3.1.2) activity and an up-regulation of the alternative NADP-glutamate dehydrogenase (NADP-GDH, EC 1.4.1.4) pathway for glutamate biosynthesis. Unless they were supplemented with glutamine, O. maius Zn transformants lacking OmGOGAT were very sensitive to zinc. These results highlight the importance of nitrogen metabolism not only for nitrogen assimilation and transformation, but also for stress tolerance. For mycorrhizal fungi, such as O. maius, this may bear consequences not only to the fungus, but also to the host plant.

  9. Maltose- and maltotriose-modified, hyperbranched poly(ethylene imine)s (OM-PEIs): Physicochemical and biological properties of DNA and siRNA complexes.

    PubMed

    Höbel, Sabrina; Loos, Andrea; Appelhans, Dietmar; Schwarz, Simona; Seidel, Jürgen; Voit, Brigitte; Aigner, Achim

    2011-01-20

    Polycationic non-viral polymers are widely employed as delivery platforms of plasmid DNA, or of small interfering RNAs (siRNAs) for the induction of RNA interference (RNAi). Among those, poly(ethylene imine)s (PEIs) take a prominent position due to their relatively high efficacy; however, their biodistribution profiles upon systemic delivery and their toxicity pose limitations which can be addressed by the introduction of PEI modifications. In this paper, we systematically analyse physicochemical and biological properties of DNA and siRNA complexes prepared from a set of maltose-, maltotriose- or maltoheptaose-modified hyperbranched PEIs (termed (oligo-)maltose-modified PEIs; OM-PEIs). We show that pH-dependent charge densities of the OM-PEIs correlate with the structure and degree of grafting, and the length of the oligomaltose. Decreased zeta potentials of OM-PEI-based complexes and changes in the thermodynamics of DNA complex formation are observed, while the complex sizes are largely unaffected by maltose grafting and the presence of serum proteins. Furthermore, although complexation efficacies of siRNAs are not altered, complex stabilities are markedly increased in OM-PEI complexes. DNA complex uptake and transfection kinetics are slowed down upon maltose-grafting of the PEI which can be attributed to decreased zeta potentials, and alterations in the uptake mechanisms (clathrin-dependent/clathrin-independent endocytosis) are observed. Independent of the maltose architecture, DNA and siRNA complexes based on maltose-grafted PEI show considerably lower cytotoxicity as compared to PEI complexes. While maltose grafting generally leads to reduced in vitro transfection efficacies, this effect is less profound in some OM-PEI/siRNA complexes as compared to OM-PEI/DNA complexes. Importantly, upon their systemic application in vivo, OM-PEI/siRNA complexes show marked differences in the siRNA biodistribution profile with e.g. substantially decreased siRNA levels in the

  10. New insights into the structure of Om Ali-Thelepte basin, central Tunisia, inferred from gravity data: Hydrogeological implications

    NASA Astrophysics Data System (ADS)

    Harchi, Mongi; Gabtni, Hakim; El Mejri, Hatem; Dassi, Lassaad; Mammou, Abdallah Ben

    2016-08-01

    This work presents new results from gravity data analyses and interpretation within the Om Ali-Thelepte (OAT) basin, central Tunisia. It focuses on the hydrogeological implication, using several qualitative and quantitative techniques such as horizontal gradient, upward continuation and Euler deconvolution on boreholes log data, seismic reflection data and electrical conductivity measurements. The structures highlighted using the filtering techniques suggest that the Miocene aquifer of OAT basin is cut by four major fault systems that trend E-W, NE-SW, NW-SE and NNE-SSW. In addition, a NW-SE gravity model established shows the geometry of the Miocene sandstone reservoir and the Upper Cretaceous limestone rocks. Moreover, the superimposition of the electrical conductivity and the structural maps indicates that the low conductivity values of sampled water from boreholes are located around main faults.

  11. CORE-OM Mental Health Norms of Students Attending University Counselling Services Benchmarked against an Age-Matched Primary Care Sample

    ERIC Educational Resources Information Center

    Connell, Janice; Barkham, Michael; Mellor-Clark, John

    2007-01-01

    Whilst concern has been expressed at the increasing severity of the mental health of students, there has been very little research on this growing population outside of small, single institution studies. The aims of this paper are to provide CORE Outcome Measure (CORE-OM) norms for the psychological health of students across multiple sites…

  12. Synthesis and characterization of novel mesocomposites Co3O4 and CuO@OMS (ordered mesoporous silica) as active catalysts for hydrocarbon oxidation

    NASA Astrophysics Data System (ADS)

    Comănescu, Cezar

    2014-03-01

    Novel metal nanoporous transition metal oxides M x O y (Co3O4, CuO) have been synthesized by thermal decomposition of inorganic salts precursors (acetates, nitrates) impregnated into hexagonal mesoporous silica (OMS, ordered mesoporous silica) of SBA-15 type (prepared in-house) at different precursor loadings, the mesocomposites thus obtained being monitored after each impregnation-calcination step by small and wide angle powder XRD. The pore size for the ordered silica host range from 5.08 to 7.06 nm. Retention of the hexagonal silica framework has been observed in spite of the temperatures up to 500 °C. Mesoporous Co3O4 has been obtained by leaching the silica through overnight HF dissolution, which partially preserved the small-range ordering found in the parent Co3O4@OMS composite prior to leaching. Both Co3O4 ( meso) and Co3O4@SBA-15 have been tested in methane oxidation and were found to be superior to the bulk Co3O4 performance, with mesoporous Co3O4 being able to fully oxidize methane to CO2 and H2O at 350 °C, while Co3O4@OMS exhibits a lower activity with 20 % conversion at 350 °C. CuO@OMS shows the lowest activity, with only 13 % conversion at 500 °C.

  13. The CORE-OM Intake Norms of Students Attending a South African University Counseling Service: A Comparison with UK Counseling Service Data

    ERIC Educational Resources Information Center

    Young, Charles

    2009-01-01

    This paper provides CORE-OM intake norms for a South African university counseling service, and compares these to the United Kingdom counseling service data reported by Connell, Barkham and Mellor-Clark (2007). The South African norms are very similar to the United Kingdom norms, with no statistical differences in the total or domain scores. There…

  14. Ultra-Wideband Optical Modulation Spectrometer (OMS) Development: Study of the Optical Setup of a Wide-Band Optical Modulation Spectrometer

    NASA Technical Reports Server (NTRS)

    Tolls, Volker; Stringfellow, Guy (Technical Monitor)

    2001-01-01

    The purpose of this study is to advance the design of the optical setup for a wide-band Optical Modulation Spectrometer (OMS) for use with astronomical heterodyne receiver systems. This report describes the progress of this investigation achieved from March until December 2001.

  15. Novel Bifunctional Nucleases, OmBBD and AtBBD1, Are Involved in Abscisic Acid-Mediated Callose Deposition in Arabidopsis1[W][OA

    PubMed Central

    You, Min Kyoung; Shin, Hyun Young; Kim, Young Jin; Ok, Sung Han; Cho, Sung Ki; Jeung, Ji Ung; Yoo, Sang Dong; Kim, Jeong Kook; Shin, Jeong Sheop

    2010-01-01

    Screening of the expressed sequence tag library of the wild rice species Oryza minuta revealed an unknown gene that was rapidly and strongly induced in response to attack by a rice fungal pathogen (Magnaporthe oryzae) and an insect (Nilaparvata lugens) and by wounding, abscisic acid (ABA), and methyl jasmonate treatments. Its recombinant protein was identified as a bifunctional nuclease with both RNase and DNase activities in vitro. This gene was designated OmBBD (for O. minuta bifunctional nuclease in basal defense response). Overexpression of OmBBD in an Arabidopsis (Arabidopsis thaliana) model system caused the constitutive expression of the PDF1.2, ABA1, and AtSAC1 genes, which are involved in priming ABA-mediated callose deposition. This activation of defense responses led to an increased resistance against Botrytis cinerea. atbbd1, the knockout mutant of the Arabidopsis ortholog AtBBD1, was susceptible to attack by B. cinerea and had deficient callose deposition. Overexpression of either OmBBD or AtBBD1 in atbbd1 plants complemented the susceptible phenotype of atbbd1 against B. cinerea as well as the deficiency of callose deposition. We suggest that OmBBD and AtBBD1 have a novel regulatory role in ABA-mediated callose deposition. PMID:20018603

  16. N/om, Change, and Social Work: A Recursive Frame Analysis of the Transformative Rituals of the Ju/'hoan Bushmen

    ERIC Educational Resources Information Center

    Keeney, Hillary; Keeney, Bradford

    2013-01-01

    The Ju/'hoan Bushman origin myth is depicted as a contextual frame for their healing and transformative ways. Using Recursive Frame Analysis, these performances are shown to be an enactment of the border crossing between First and Second Creation, that is, pre-linguistic and linguistic domains of experience. Here n/om, or the presumed creative…

  17. H2 Production Through the Water-gas Shift Reaction: An In situ Time-resolved X-ray Diffraction Investigation of Manganese OMS-2 Catalyst

    SciTech Connect

    Hanson, J.C.; Sithambaram, S.; Wen, W.; Njagi, E.; Shen, X.-F.; Suib, S.L.

    2010-10-01

    Manganese oxide octahedral molecular sieve (OMS-2) catalyst prepared by the reflux method was investigated for hydrogen generation via the water-gas shift reaction. Catalysts were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), The Brunauer-Emmett-Teller (BET) surface area and determination of average oxidation state (AOS). The OMS-2 catalyst showed very good catalytic activity for the water-gas shift reaction to generate hydrogen under laboratory conditions. An in situ study was conducted to monitor the structural changes in the catalyst during the water-gas shift reaction using synchrotron radiation-based time-resolved X-ray diffraction (TR-XRD). During the water-gas shift reaction, the mixed valent OMS-2 catalyst undergoes a structural transformation to form Mn{sub 2}O{sub 3} and finally to form MnO. The study showed that OMS-2 catalysts can be used as inexpensive catalysts for hydrogen generation.

  18. H2 production Through the Water-gas Shift Reaction: An in Situ Time-resolved X-ray Diffraction Investigation of Manganese OMS-2 Catalyst

    SciTech Connect

    Sithambaram, S.; Wen, W; Njagi, E; Shen, X; Hanson, J; Suib, S

    2010-01-01

    Manganese oxide octahedral molecular sieve (OMS-2) catalyst prepared by the reflux method was investigated for hydrogen generation via the water-gas shift reaction. Catalysts were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), The Brunauer-Emmett-Teller (BET) surface area and determination of average oxidation state (AOS). The OMS-2 catalyst showed very good catalytic activity for the water-gas shift reaction to generate hydrogen under laboratory conditions. An in situ study was conducted to monitor the structural changes in the catalyst during the water-gas shift reaction using synchrotron radiation-based time-resolved X-ray diffraction (TR-XRD). During the water-gas shift reaction, the mixed valent OMS-2 catalyst undergoes a structural transformation to form Mn{sub 2}O{sub 3} and finally to form MnO. The study showed that OMS-2 catalysts can be used as inexpensive catalysts for hydrogen generation.

  19. 78 FR 79481 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... actions in response to violations of Commission APOs and the 24-hour rule. See 56 FR 4846 (February 6, 1991); 57 FR 12335 (April 9, 1992); 58 FR 21991 (April 26, 1993); 59 FR 16834 (April 8, 1994); 60 FR 24880 (May 10, 1995); 61 FR 21203 (May 9, 1996); 62 FR 13164 (March 19, 1997); 63 FR 25064 (May 6,...

  20. To investigate the prevention of OM-85 on bronchiectasis exacerbations (iPROBE) in Chinese patients: study protocol for a randomized controlled trial

    PubMed Central

    2014-01-01

    Background Non-cystic fibrosis bronchiectasis is characterized by the irreversible dilatation of the medium-sized bronchi as a result of airway injury from recurrent or chronic inflammation and lower respiratory tract infections. Bronchiectasis airways are commonly colonized with bacterial species. Infections of the airways play important role in bronchiectasis exacerbations. The non-specific prevention of recurrent airway infections by immunostimulating agents has gained growing interest. OM-85, consisting of extracts of eight kinds of bacteria important in respiratory infections, could support the respiratory tract resistance to the pathogens. OM-85 has been shown to be a benefit by decreasing the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) in several perspective clinical trials. Exacerbation of bronchiectasis substantially contributes to a more rapid decline in lung function, reduced quality of life, and healthcare costs. In this context, we plan to conduct a clinical trial to investigate the PReventive effect of OM-85 on Bronchiectasis Exacerbation in Chinese patients (iPROBE). Methods/Design This study is designed as a prospective, randomized, double blind, placebo-controlled multicenter trial. A total of 244 patients with bronchiectasis, who have had at least one exacerbation of bronchiectasis in the previous year, will be included. The subjects will randomly receive two courses of 7 mg of OM-85 or a matching placebo. The treatment dose of OM-85 will be one daily capsule taken orally for 10 days each month for 3 consecutive months at the beginning of the study, followed by 3 months of no drug. This schedule will repeat until the patient has been seen for one year. Discussion We will investigate whether long-term treatment with an oral immunostimulant (OM-85) could decrease exacerbations of bronchiectasis over a one-year period. We will also assess other relevant outcomes, including the rate of event-based exacerbation, lung

  1. Safety and efficacy of two courses of OM-85 BV in the prevention of respiratory tract infections in children during 12 months.

    PubMed

    Gutiérrez-Tarango, M D; Berber, A

    2001-06-01

    Acute respiratory tract infections (ARTIs) are among the main causes of morbidity and mortality in children. The bacterial extract OM-85 BV (bronchovaxom) has shown protective effect for ARTIs on children. We report a double-blind, placebo-controlled, parallel, prospective clinical trial to assess the safety and efficacy of two courses of OM-85 BV in the prevention of ARTIs in susceptible children during 12 months. Fifty-four susceptible children from 1 to 12 years of age living in the metropolitan area of Chihuahua City were selected. They were randomized to receive either OM-85 BV or placebo (one capsule a day for 10 days a month for 3 consecutive months) at the beginning of the trial and 6 months later with the same schedule. Patients were followed up for 12 months, including the administration period. The trial began in July 1997 and ended in April 1999. The number (mean +/- SD) of ARTIs was 5.04 +/- 1.99 (median, 5.0) in the OM-85 BV group vs 8.0 +/- 2.55 (median, 8.0) in the placebo group, with a mean difference of - 2.96 (95% confidence interval [CI], - 4.22 to - 1.7). The number of antibiotic courses was 2.46 +/- 2.08 (median, 1.5) in the treatment group vs 4.46 +/- 2.08 (median, 4.0) in the control group, a difference of - 2.0 (95% CI, - 3.14 to - 0.86). The total duration of ARTIs was 35.23 +/- 17.64 days (median, 30.5 days) in the OM-85 BV group vs 60.75 +/- 25.44 days (median, 55.0 days) in the placebo group, ie, a difference of - 25.52 days (95% CI, - 37.56 to - 13.47 days), p < 0.001 by Student's t test and Mann-Whitney U test for all the items. Four patients in the OM-85 BV group had five adverse events. Only one episode of skin rash was related to the medication intake. Six patients in the control group had six adverse events. OM-85 BV had a preventive effect on ARTI in the susceptible children for 12 months with an important reduction on the antibiotic requirements and the number of days of suffering ARTIs.

  2. CCR4 agonists CCL22 and CCL17 are elevated in pediatric OMS sera: rapid and selective down-regulation of CCL22 by ACTH or corticosteroids.

    PubMed

    Pranzatelli, Michael R; Tate, Elizabeth D; McGee, Nathan R; Colliver, Jerry A; Ransohoff, Richard M

    2013-05-01

    To study the role of Th2-attracting chemokines in opsoclonus-myoclonus syndrome (OMS), a serious neurological paraneoplastic disorder in need of better immunological understanding and therapy. The CCR4 agonists CCL22 and CCL17 were measured in serum by ELISA in children with OMS (238 and 260, respectively), pediatric controls (115 and 143), and other inflammatory neurological disorders (33 and 24). Both CCL22 (+55 %) and CCL17 (+121 %) were significantly elevated in untreated OMS compared to controls and inter-correlated (p < 0.0001). Their concentrations in untreated OMS also were higher than in OIND (21 %, 41 %). The concentration of CCL22 in ACTH and steroids groups (not IVIg) was 51 % lower than in controls, but only a smaller effect of ACTH on CCL17 was found. Prospective longitudinal studies revealed a precipitous 81 % drop in CCL22 even by the first week of high-dose ACTH therapy, staying below control mean for at least 12 weeks, and a 34 % reduction after 8 months of combined treatment. Response to ACTH was dose-related (r = -0.50, p < 0.0001). Luminex detection confirmed the ELISA results for CCL22, which were about 200 % higher. These data reveal an elevated serum concentration of Th2-attracting chemokines CCL22 and CCL17 in OMS. Marked and rapid reduction in CCL22, not CCL17, with either ACTH or steroid therapy suggests differential regulation and cellular sources of CCR4 ligands, and CCL22 as a potential candidate biomarker for ACTH or corticosteroid effect.

  3. The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase

    SciTech Connect

    Ridder, Mark de . E-mail: Mark.De.Ridder@vub.ac.be; Verovski, Valeri N.; Chiavaroli, Carlo; Berge, Dirk L. van den; Monsaert, Christinne; Law, Kalun; Storme, Guy A.

    2006-12-01

    Purpose: To explore whether antitumor immunoadjuvant OM-174 can stimulate immune cells to produce interferon-{gamma} (IFN-{gamma}) and thereby radiosensitize tumor cells. Methods and Materials: Splenocytes from BALB/c mice were stimulated by OM-174 at plasma-achievable concentrations (0.03-3 {mu}g/mL), and afterward analyzed for the expression and secretion of IFN-{gamma} by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Stimulated splenocytes were used as a source of IFN-{gamma} to radiosensitize hypoxic EMT-6 tumor cells through the cytokine-inducible isoform of nitric oxide synthase (iNOS). Results: OM-174 activated the production of IFN-{gamma} at high levels that reached 70 ng/mL in normoxia (21% oxygen) and 27 ng/mL in tumor-relevant hypoxia (1% oxygen). This caused up to 2.1-fold radiosensitization of EMT-6 tumor cells, which was associated with the iNOS-mediated production of the radiosensitizing molecule nitric oxide, as confirmed by accumulation of its oxidative metabolite nitrite, Western blot analysis, and reverse transcriptase-polymerase chain reaction. Both iNOS activation and radiosensitization were counteracted by neutralizing antibodies against IFN-{gamma}. The same mechanism of radiosensitization through the IFN-{gamma} secretion pathway was identified for IL-12 + IL-18, which are known to mediate IFN-{gamma} responses. Hypoxia displayed a dual effect on the immune-tumor cell interaction, by downregulating the expression of the IFN-{gamma} gene while upregulating iNOS at transcriptional level. Conclusion: Immunoadjuvant OM-174 is an efficient radiosensitizer of tumor cells through activation of the IFN-{gamma} secretion pathway in immune cells. This finding indicates a rationale for combining immunostimulatory and radiosensitizing strategies and extends the potential therapeutic applications of OM-174.

  4. Effective removal of effluent organic matter (EfOM) from bio-treated coking wastewater by a recyclable aminated hyper-cross-linked polymer.

    PubMed

    Yang, Wenlan; Li, Xuchun; Pan, Bingcai; Lv, Lu; Zhang, Weiming

    2013-09-01

    Effluent organic matter (EfOM) is a complex matrix of organic substance mainly from bio-treated sewage effluent and is considered as the main constraint to further advanced treatment. Here a recyclable aminated hyper-cross-linked polymeric adsorbent (NDA-802) featured with aminated functional groups, large specific surface area, and sufficient micropore region was synthesized for effective removal of EfOM from the bio-treated coking wastewater (BTCW), and its removal characteristics was investigated. It was found that hydrophobic fraction was the main constituent (64.8% of DOC) in EfOM of BTCW, and the hydrophobic-neutral fraction had the highest SUVA level (7.06 L mg(-1) m(-1)), which were significantly different from that in the domestic wastewater. Column adsorption experiments showed that NDA-802 exhibited much higher removal efficiency of EfOM than other polymeric adsorbents D-301, XAD-4, and XAD-7, and the efficiency could be readily sustained according to continuous 28-cycle batch adsorption-regeneration experiments. Moreover, dissolved organic matter (DOM) fractionation and excitation-emission matrix (EEM) fluorescence spectroscopy study indicated that NDA-802 showed attractive adsorption preference as well as high removal efficiency of hydrophobic and aromatic compounds. Possibly ascribed to the presence of functional aminated groups, relatively large specific surface area and micropore region of the unique polymer, NDA-802 possesses high and sustained efficiency for the removal of EfOM, and provides a potential alternative for the advanced treatment. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Chemokine/cytokine profiling after rituximab: reciprocal expression of BCA-1/CXCL13 and BAFF in childhood OMS.

    PubMed

    Pranzatelli, Michael R; Tate, Elizabeth D; Travelstead, Anna L; Verhulst, Steven J

    2011-03-01

    The aim of the study was to test the hypothesis that B-cell repopulation following rituximab (anti-CD20) therapy is orchestrated by chemokines and non-chemokine cytokines. Twenty-five children with opsoclonus-myoclonus syndrome (OMS) received rituximab with or without conventional agents. A comprehensive panel of 40 chemokines and other cytokines were measured in serum by ELISA and multiplexed fluorescent bead-based immunoassay. Serum BAFF concentration changed dramatically (even after first infusion) and inversely with B-cell depletion/repopulation and CXCL13 concentration at 1, 3, and 6 months. Negative correlations were found for BAFF concentration vs blood B cell percentage and serum CXCL13 concentration; positive correlations with serum rituximab concentrations. Six months after initiation of therapy, no significant difference in the levels of APRIL, CXCL10, IL-6, or 17 other cytokines/chemokines were detected. These data reveal a major role for BAFF in peripheral B cell repopulation following rituximab-induced B-cell depletion, and novel changes in CXCL13. ClinicalTrials.gov NCT0024436.

  6. Metroplex Optimization Model Expansion and Analysis: The Airline Fleet, Route, and Schedule Optimization Model (AFRS-OM)

    NASA Technical Reports Server (NTRS)

    Sherry, Lance; Ferguson, John; Hoffman, Karla; Donohue, George; Beradino, Frank

    2012-01-01

    This report describes the Airline Fleet, Route, and Schedule Optimization Model (AFRS-OM) that is designed to provide insights into airline decision-making with regards to markets served, schedule of flights on these markets, the type of aircraft assigned to each scheduled flight, load factors, airfares, and airline profits. The main inputs to the model are hedged fuel prices, airport capacity limits, and candidate markets. Embedded in the model are aircraft performance and associated cost factors, and willingness-to-pay (i.e. demand vs. airfare curves). Case studies demonstrate the application of the model for analysis of the effects of increased capacity and changes in operating costs (e.g. fuel prices). Although there are differences between airports (due to differences in the magnitude of travel demand and sensitivity to airfare), the system is more sensitive to changes in fuel prices than capacity. Further, the benefits of modernization in the form of increased capacity could be undermined by increases in hedged fuel prices

  7. Post-irradiation effect of Broncho-Vaxom, OM-85 BV, and its relationship to anti-oxidant activities.

    PubMed

    Saada, H N; Azab, K S; Zahran, A M

    2001-08-01

    This study was conducted to test the efficacy of Broncho-Vaxom (OM-85 BV) in rats after exposure to radiation-induced oxidative stress. Daily administration of Broncho-Vaxom (2.5 mg/kg/day) to rats for a period of 28 days produced a progressive significant increase in the activities of superoxide dismutase (SOD) and catalase in lungs and erythrocytes. No changes were recorded in reduced glutathione (GSH) content in lungs, while an increase was recorded in erythrocytes. Significant increase was also observed in serum gamma-globulin content. Intraperitoneal administration of Broncho-Vaxom to rats for 11 days before gamma-irradiation and daily during the period of irradiation, delivered as 1 Gy every other day to reach 9 Gy, significantly reduced radiation-induced lipid peroxidation (LPO) measured as thiobarbituric acid-reactive substances (TBARS) in the lungs and erythrocytes. Treatment with Broncho-Vaxom modified the radiation-induced decrease of serum gamma-globulins contents. It is postulated that Broncho-Vaxom, by enhancing the antioxidant system and increasing serum gamma-globulin content, could play an important role in modifying radiation-induced oxidative stress.

  8. Growth of InSb and InAs(1-x)Sb(x) by OM-CVD

    NASA Technical Reports Server (NTRS)

    Chiang, P. K.; Bedair, S. M.

    1984-01-01

    Organometallic chemical vapor deposition (OM-CVD) growth of InSb and InAs(1-x)Sb(x) has been obtained using triethylindium (TEI), trimethylantimony (TMS), and arsine (AsH3) on (100) GaAs, (100) InSb, and (111)-B InSb substrates. InSb with excellent morphology was achieved on both (100) InSb and (111)-B InSb substrates. The measured electron mobility at 300 K of undoped InSb grown on (100) GaAs semi-insulating substrates was 40,000 sq cm/V-s at a carrier concentration of ND-NA = 2.0 x 10 to the 16th per cu cm. Carrier concentration of ND-NA = 1.2 x 10 to the 15th per cu cm has been measured at 77 K. InAs(1-x)Sb(x) (x = 0.07-0.75) with mirror-like surfaces have been grown on (100) InSb and InAs substrates. This composition range of x between 0.55 and 0.75 (Eg = 0.1 eV) has been successfully achieved for the first time. Solid composition variations as a function of growth temperature and InSb substrate orientations are also discussed.

  9. New synthetic routes to catalytically active manganite, K-OMS-2 and K-OMS-2/silicon dioxide and a preliminary study on the use of a continuous flow microwave technique in the synthesis of nanosized manganese and cerium oxides and cobalt and iron oxyhydroxides

    NASA Astrophysics Data System (ADS)

    Crisostomo, Vincent Mark B.

    The work presented here comprises three main parts. The first part is a new route to nano-sized gamma-MnOOH (manganite). gamma-MnOOH has been synthesized via the reduction of KMnO4 with sucrose and MnSO 4 in acidic medium under refluxing conditions for four and six hours. Characterization of these manganite materials using XRD, FESEM, TEM, TGA and IR were done. The obtained manganite samples using the new route were compared against a conventionally prepared one where synthesis involved the oxidation of MnSO4 with H2O2 in basic medium. Two new synthetic methods were developed, one involving addition of KMnO4 into a solution of both sucrose and MnSO4 while the other involved addition of KMnO4 solution into sucrose followed by addition of MnSO4 (s). The latter method yielded smaller particles (up to 30 nm) than the former method (up to 80 nm) and the conventionally prepared manganite (up to 50 nm). The synthesized manganite materials exhibited promising characteristics when tested as electrocatalysts in O2 reduction. The larger particles gave higher peak currents in CV than smaller particles. When incorporated in Yardney's medium-sized lithium-air battery, the larger (up to 80 nm) particles gave higher specific capacity (up to 2.2 Ah/g), which corresponds to about 38% increase in specific energy of the battery when compared to a battery where no manganite was incorporated. The second part of the research reported here involves the synthesis of K-OMS-2 and SiO2-supported K-OMS-2. K-OMS-2 (or OMS-2 from hereon) was successfully synthesized using a reflux method where, for the first time, oxone or KHSO5 was used as the oxidant. Nano-sized fibers with widths ranging from 8--40 nm were obtained. We also report for the first time the synthesis and catalytic activity of OMS-2 supported on SiO2 with surface area ranging from 228 to 513 m2/g and weight % OMS-2 ranging from 1.0 to 13.6%. An optimization study on styrene oxidation using OMS-2 and OMS-2/SiO2 as catalysts was

  10. Service profiling and outcomes benchmarking using the CORE-OM: toward practice-based evidence in the psychological therapies. Clinical Outcomes in Routine Evaluation-Outcome Measures.

    PubMed

    Barkham, M; Margison, F; Leach, C; Lucock, M; Mellor-Clark, J; Evans, C; Benson, L; Connell, J; Audin, K; McGrath, G

    2001-04-01

    To complement the evidence-based practice paradigm, the authors argued for a core outcome measure to provide practice-based evidence for the psychological therapies. Utility requires instruments that are acceptable scientifically, as well as to service users, and a coordinated implementation of the measure at a national level. The development of the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) is summarized. Data are presented across 39 secondary-care services (n = 2,710) and within an intensively evaluated single service (n = 1,455). Results suggest that the CORE-OM is a valid and reliable measure for multiple settings and is acceptable to users and clinicians as well as policy makers. Baseline data levels of patient presenting problem severity, including risk, are reported in addition to outcome benchmarks that use the concept of reliable and clinically significant change. Basic quality improvement in outcomes for a single service is considered.

  11. A magnetic route to measure the average oxidation state of mixed-valent manganese in manganese oxide octahedral molecular sieves (OMS).

    PubMed

    Shen, Xiong-Fei; Ding, Yun-Shuang; Liu, Jia; Han, Zhao-Hui; Budnick, Joseph I; Hines, William A; Suib, Steven L

    2005-05-04

    A magnetic route has been applied for measurement of the average oxidation state (AOS) of mixed-valent manganese in manganese oxide octahedral molecular sieves (OMS). The method gives AOS measurement results in good agreement with titration methods. A maximum analysis deviation error of +/-7% is obtained from 10 sample measurements. The magnetic method is able to (1) confirm the presence of mixed-valent manganese and (2) evaluate AOS and the spin states of d electrons of both single oxidation state and mixed-valent state Mn in manganese oxides. In addition, the magnetic method may be extended to (1) determine AOS of Mn in manganese oxide OMS with dopant "diamagnetic" ions, such as reducible V5+ (3d0) ions, which is inappropriate for the titration method due to interference of redox reactions between these dopant ions and titration reagents, such as KMnO4, (2) evaluate the dopant "paramagnetic" ions that are present as clusters or in the OMS framework, and (3) determine AOS of other mixed-valent/single oxidation state ion systems, such as Mo3+(3d3)-Mo4+(3d2) systems and Fe3+ in FeCl3.

  12. Seasonal and spatial variability of the OM/OC mass ratios and high regional correlation between oxalic acid and zinc in Chinese urban organic aerosols

    NASA Astrophysics Data System (ADS)

    Xing, L.; Fu, T.-M.; Cao, J. J.; Lee, S. C.; Wang, G. H.; Ho, K. F.; Cheng, M.-C.; You, C.-F.; Wang, T. J.

    2013-04-01

    We calculated the organic matter to organic carbon mass ratios (OM/OC mass ratios) in PM2.5 collected from 14 Chinese cities during summer and winter of 2003 and analyzed the causes for their seasonal and spatial variability. The OM/OC mass ratios were calculated two ways. Using a mass balance method, the calculated OM/OC mass ratios averaged 1.92 ± 0.39 year-round, with no significant seasonal or spatial variation. The second calculation was based on chemical species analyses of the organic compounds extracted from the PM2.5 samples using dichloromethane/methanol and water. The calculated OM/OC mass ratio in summer was relatively high (1.75 ± 0.13) and spatially-invariant due to vigorous photochemistry and secondary organic aerosol (OA) production throughout the country. The calculated OM/OC mass ratio in winter (1.59 ± 0.18) was significantly lower than that in summer, with lower values in northern cities (1.51 ± 0.07) than in southern cities (1.65 ± 0.15). This likely reflects the wider usage of coal for heating purposes in northern China in winter, in contrast to the larger contributions from biofuel and biomass burning in southern China in winter. On average, organic matter constituted 36% and 34% of Chinese urban PM2.5 mass in summer and winter, respectively. We report, for the first time, a high regional correlation between Zn and oxalic acid in Chinese urban aerosols in summer. This is consistent with the formation of stable Zn oxalate complex in the aerosol phase previously proposed by Furukawa and Takahashi (2011). We found that many other dicarboxylic acids were also highly correlated with Zn in the summer Chinese urban aerosol samples, suggesting that they may also form stable organic complexes with Zn. Such formation may have profound implications for the atmospheric abundance and hygroscopic properties of aerosol dicarboxylic acids.

  13. KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare to remove one of two orbital maneuvering system (OMS) pods from Endeavour. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

    NASA Image and Video Library

    2003-09-05

    KENNEDY SPACE CENTER, FLA. - Workers in the Orbiter Processing Facility prepare to remove one of two orbital maneuvering system (OMS) pods from Endeavour. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

  14. KENNEDY SPACE CENTER, FLA. - Technicians in the Orbiter Processing Facility oversee removal of one of two orbital maneuvering system (OMS) pods from Endeavour. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

    NASA Image and Video Library

    2003-09-05

    KENNEDY SPACE CENTER, FLA. - Technicians in the Orbiter Processing Facility oversee removal of one of two orbital maneuvering system (OMS) pods from Endeavour. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

  15. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods removed from Endeavour is lowered toward a transporter. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

    NASA Image and Video Library

    2003-09-05

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods removed from Endeavour is lowered toward a transporter. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

  16. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods removed from Endeavour is suspended overhead. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

    NASA Image and Video Library

    2003-09-05

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods removed from Endeavour is suspended overhead. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

  17. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods removed from Endeavour is lowered onto a transporter. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

    NASA Image and Video Library

    2003-09-05

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods removed from Endeavour is lowered onto a transporter. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts. OMS pods are removed during Orbiter Major Modifications. Once removed, the OMS pods undergo in-depth structural inspections, system checks and the thrusters are changed out.

  18. Novel synthesis of manganese and vanadium mixed oxide (V{sub 2}O{sub 5}/OMS-2) as an efficient and selective catalyst for the oxidation of alcohols in liquid phase

    SciTech Connect

    Mahdavi, Vahid Soleimani, Shima

    2014-03-01

    Graphical abstract: Oxidation of various alcohols is studied in the liquid phase over new composite mixed oxide (V{sub 2}O{sub 5}/OMS-2) catalyst using tert-butyl hydroperoxide (TBHP). The activity of V{sub 2}O{sub 5}/OMS-2 samples was considerably increased with respect to OMS-2 catalyst and these samples are found to be suitable for the selective oxidation of alcohols. - Highlights: • V{sub 2}O{sub 5}/K-OMS-2 with different V/Mn molar ratios prepared by the impregnation method. • Oxidation of alcohols was studied in the liquid phase over V{sub 2}O{sub 5}/K-OMS-2 catalyst. • V{sub 2}O{sub 5}/K-OMS-2 catalyst had excellent activity for alcohol oxidation. • Benzyl alcohol oxidation using excess TBHP followed a pseudo-first order kinetic. • The selected catalyst was reused without significant loss of activity. - Abstract: This work reports the synthesis and characterization of mixed oxide vanadium–manganese V{sub 2}O{sub 5}/K-OMS-2 at various V/Mn molar ratios and prepared by the impregnation method. Characterization of these new composite materials was made by elemental analysis, BET, XRD, FT-IR, SEM and TEM techniques. Results of these analyses showed that vanadium impregnated samples contained mixed phases of cryptomelane and crystalline V{sub 2}O{sub 5} species. Oxidation of various alcohols was studied in the liquid phase over the V{sub 2}O{sub 5}/K-OMS-2 catalyst using tert-butyl hydroperoxide (TBHP) and H{sub 2}O{sub 2} as the oxidant. Activity of the V{sub 2}O{sub 5}/K-OMS-2 samples was increased considerably with respect to K-OMS-2 catalyst due to the interaction of manganese oxide and V{sub 2}O{sub 5}. The kinetic of benzyl alcohol oxidation using excess TBHP over V{sub 2}O{sub 5}/K-OMS-2 catalyst was investigated at different temperatures and a pseudo-first order reaction was determined with respect to benzyl alcohol. The effects of reaction time, oxidant/alcohol molar ratio, reaction temperature, solvents, catalyst recycling potential and

  19. 76 FR 65653 - New Source Performance Standards (NSPS) Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-24

    ... Plants: Electric Arc Furnaces AA 09/23/1975 (40FR43850) 02/22/2005 (70FR8532) Steel Plants: Electric Arc... 12/24/1980 (45FR85410) 10/17/2000 3 4 (65FR61760) Coating. Basic Oxygen Process Furnaces...... N 03... (65FR61778) Industries. Coal Prep Plants Y 01/15/1976 (41FR2234) 10/08/2009 (74FR51977) Electric Utility...

  20. Zeitschriftenschau. Lernziel: Kommunikation (Review of Journals. Teaching Goal: Communication)

    ERIC Educational Resources Information Center

    Zielsprache Franzosisch, 1975

    1975-01-01

    Reviews four articles on communicative competence as a goal of study, chosen from 1974-75 issues of four journals. Topics discussed include: Setting goals, ascertaining levels of achievement in communication, possibility of sectioning groups according to ability, and actualizing communicative activity in the classroom. (Text is in German.)…

  1. Definition von Datenarten zur konsistenten Kommunikation im Unternehmen

    NASA Astrophysics Data System (ADS)

    Piro, Andrea; Gebauer, Marcus

    Probleme in der Informationsqualität (IQ) treten in den unterschiedlichsten Bereichen eines Unternehmens auf und werden durch die unterschiedlichsten Bereiche verursacht. Daher ist es um so wichtiger, diese Probleme klar und eindeutig kommunizieren zu können. Insbesondere wenn Kollegen fachübergreifend IQ-Probleme beheben wollen, kann dies schwierig sein. Erst wenn klar ist, worüber geredet wird, und häufig sind dies Datenfelder und ihr Inhalt, kann das Problem eindeutig beschrieben und gelöst werden.

  2. Visuelle Kommunikation im Fremdsprachenunterricht (Visual Communication in Foreign Language Teaching)

    ERIC Educational Resources Information Center

    Koehring, Klaus H.

    1975-01-01

    Starts with a critique of the skill-oriented, teacher-centered concept of language learning: teacher as director and explainer, giving purely verbal training. Presents then a communication-oriented, learner-centered, "all-pragmatic" concept, emphasizing "social events." Suggests, with examples, reforming practice to develop learners'"signal…

  3. Definition von Datenarten zur konsistenten Kommunikation im Unternehmen

    NASA Astrophysics Data System (ADS)

    Piro, Andrea; Gebauer, Marcus

    Probleme in der Informationsqualität (IQ) treten in den unterschiedlichsten Bereichen eines Unternehmens auf und werden durch die unterschiedlichsten Bereiche verursacht. Daher ist es um so wichtiger, diese Probleme klar und eindeutig kommunizieren zu können. Insbesondere wenn Kollegen fachübergreifend IQProbleme beheben wollen, kann dies schwierig sein. Erst wenn klar ist, worüber geredet wird, und häufig sind dies Datenfelder und ihr Inhalt, kann das Problem eindeutig beschrieben und gelöst werden.

  4. Comprehensive Genomic Analyses of the OM43 Clade, Including a Novel Species from the Red Sea, Indicate Ecotype Differentiation among Marine Methylotrophs

    PubMed Central

    Jimenez-Infante, Francy; Ngugi, David Kamanda; Vinu, Manikandan; Alam, Intikhab; Kamau, Allan Anthony; Blom, Jochen; Bajic, Vladimir B.

    2015-01-01

    The OM43 clade within the family Methylophilaceae of Betaproteobacteria represents a group of methylotrophs that play important roles in the metabolism of C1 compounds in marine environments and other aquatic environments around the globe. Using dilution-to-extinction cultivation techniques, we successfully isolated a novel species of this clade (here designated MBRS-H7) from the ultraoligotrophic open ocean waters of the central Red Sea. Phylogenomic analyses indicate that MBRS-H7 is a novel species that forms a distinct cluster together with isolate KB13 from Hawaii (Hawaii-Red Sea [H-RS] cluster) that is separate from the cluster represented by strain HTCC2181 (from the Oregon coast). Phylogenetic analyses using the robust 16S-23S internal transcribed spacer revealed a potential ecotype separation of the marine OM43 clade members, which was further confirmed by metagenomic fragment recruitment analyses that showed trends of higher abundance in low-chlorophyll and/or high-temperature provinces for the H-RS cluster but a preference for colder, highly productive waters for the HTCC2181 cluster. This potential environmentally driven niche differentiation is also reflected in the metabolic gene inventories, which in the case of the H-RS cluster include those conferring resistance to high levels of UV irradiation, temperature, and salinity. Interestingly, we also found different energy conservation modules between these OM43 subclades, namely, the existence of the NADH:quinone oxidoreductase complex I (NUO) system in the H-RS cluster and the nonhomologous NADH:quinone oxidoreductase (NQR) system in the HTCC2181 cluster, which might have implications for their overall energetic yields. PMID:26655752

  5. Evaluation of different conditions to enhance the performances of Lactobacillus pentosus OM13 during industrial production of Spanish-style table olives.

    PubMed

    Martorana, Alessandra; Alfonzo, Antonio; Gaglio, Raimondo; Settanni, Luca; Corona, Onofrio; La Croce, Francesco; Vagnoli, Paola; Caruso, Tiziano; Moschetti, Giancarlo; Francesca, Nicola

    2017-02-01

    The main objective was to set up a methodology to improve the high volume production of green table olives, cv. Nocellara del Belice. Lactobacillus pentosus OM13 was applied during three different industrial processes of table olives as follows: trial one (IOP1) was subjected to an addition of lactic acid until a brine level of pH 7.0 was reached; trial two (IOP2) subjected to same addition of lactic acid as in trial one plus nutrient adjuvant and trial three (IOP3) subjected to same addition as trial two, but with the strain L. pentosus OM13 acclimatized in brine for 12 h before inoculation. These trials were compared against two untreated controls (spontaneously fermented and addition of L. pentosus OM13 only). Within the third day of fermentation, the pH of the brines decreased significantly, reaching pH 4.85 for trial three, pH 5.15 for trial two, and pH 5.92 for trial one. The pH of both controls decreased more slowly, and had values below pH 5.0 only after the fifteenth day of fermentation (control one) and the sixty-fifth day of fermentation (control two). Trial three reached the highest lactic acid bacteria (LAB) concentration on the third day of fermentation. After six days of fermentation, all trials showed similar values of LAB counts that were significantly higher compared to control number one. The result from genotypic identification showed that L. pentosus OM13 was the most frequently isolated in the inoculated trials. Lactobacillus plantarum, Lactobacillus coryniformis and Pediococcus pentosaceous were also detected at very low concentrations. Homoguaiacol, 2-butanol, 4-ethylphenol, phenylethyl alcohol and 4-ethylphenol were the volatile organic compounds detected at the highest levels in all experimental trials. Trial three showed a higher concentration of squalene that was not detected in other trials. The highest sensory scores of green olive aroma and overall satisfaction were found for all experimental olives, especially for those of trial

  6. Removal and transformation of effluent organic matter (EfOM) in biotreated textile wastewater by GAC/O3 pre-oxidation and enhanced coagulation.

    PubMed

    Qian, Feiyue; Sun, Xianbo; Liu, Yongdi; Xu, Hongyong

    2013-01-01

    GAC/O3 (ozonation in the presence of granular activated carbon) combined with enhanced coagulation was employed to process biotreated textile wastewater for possible reuse. The doses of ozone, GAC and coagulant were the variables studied for optimization. The effects of different treatment processes on effluent organic matter (EfOM) characteristics, including biodegradability, hydrophobic and hydrophilic nature, and apparent molecular weight (AMW) distribution were also investigated. Compared with ozonation, GAC/O3 not only presented a higher pre-oxidation efficiency, but also improved the treatability of hydrophobic and high molecular weight compounds by enhanced coagulation. After treatment by GAC/O3 pre-oxidation (0.6 mg O3 x mg(-1) COD and 20 g x L(-1) GAC) and enhanced coagulation (25 mg x L(-1) Al3+ at pH 5.5), the removal efficiencies of chemical oxygen demand (COD), dissolved organic carbon (DOC) and colour were higher than those for coagulation alone by 17.3%, 12.0% and 25.6%, respectively. Residual organic matter consisted mainly of hydrophobic acids and hydrophilic compounds of AMW < 1 kDa, which were colourless and of limited biological availability. The combination of GAC/O3 and enhanced coagulation was proved to be a simple and effective treatment strategy for removing EfOM from biotreated textile wastewater.

  7. Structural and electronic properties of UnOm (n=1-3,m=1-3n) clusters: A theoretical study using screened hybrid density functional theory.

    PubMed

    Yang, Yu; Liu, Haitao; Zhang, Ping

    2016-05-14

    The structural and electronic properties of small uranium oxide clusters UnOm (n=1-3, m=1-3n) are systematically studied within the screened hybrid density functional theory. It is found that the formation of U-O-U bondings and isolated U-O bonds are energetically more stable than U-U bondings. As a result, no uranium cores are observed. Through fragmentation studies, we find that the UnOm clusters with the m/n ratio between 2 and 2.5 are very stable, hinting that UO2+x hyperoxides are energetically stable. Electronically, we find that the O-2p states always distribute in the deep energy range, and the U-5f states always distribute at the two sides of the Fermi level. The U-6d states mainly hybridize with the U-5f states in U-rich clusters, while hybridizing with O-2p states in O-rich clusters. Our work is the first one on the screened hybrid density functional theory level studying the atomic and electronic properties of the actinide oxide clusters.

  8. Aqueous magnesium ion battery based on carbon-coated FeVO4 as anode and Mg-OMS-1 as cathode with high energy density.

    PubMed

    Zhang, Hongyu; Ye, Ke; Zhu, Kai; Cang, Ruibai; Yan, Jun; Cheng, Kui; Wang, Guiling; Cao, Dianxue

    2017-09-21

    The porous FeVO4 is prepared by hydrothermal method and further modified by coating carbon to obtain the FeVO4/C with hierarchical pore structure, which are used as anodic electrodes in aqueous rechargeable magnesium ion battery. And the FeVO4/C material can not only improve the electrical conductivity by coating a carbon layer but also increase the specific surface area by hierarchical pore structure, which is more beneficial for magnesium ion insertion/deinsertion. Therefore, the aqueous rechargeable magnesium ion full battery is successfully constructed by FeVO4/C as anode, Mg-OMS-1 as cathode and in 1.0 mol L-1 MgSO4 as electrolyte. The discharge capacity of Mg-OMS-1 // FeVO4/C aqueous battery can be obtained 58.9 mAh g-1 at the current density of 100 mA g-1 by calculating the total mass of two electrodes and the capacity retention rate of this device is 97.7% after 100 cycles with the nearly 100% coulombic efficiency, which indicates that the system owns a good electrochemical reversibility. More than that, this system can achieve a high energy density of 70.4 Wh kg-1, which provides a powerful evidence to make the aqueous magnesium ion battery possible. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Observ-OM and Observ-TAB: Universal syntax solutions for the integration, search, and exchange of phenotype and genotype information.

    PubMed

    Adamusiak, Tomasz; Parkinson, Helen; Muilu, Juha; Roos, Erik; van der Velde, Kasper Joeri; Thorisson, Gudmundur A; Byrne, Myles; Pang, Chao; Gollapudi, Sirisha; Ferretti, Vincent; Hillege, Hans; Brookes, Anthony J; Swertz, Morris A

    2012-05-01

    Genetic and epidemiological research increasingly employs large collections of phenotypic and molecular observation data from high quality human and model organism samples. Standardization efforts have produced a few simple formats for exchange of these various data, but a lightweight and convenient data representation scheme for all data modalities does not exist, hindering successful data integration, such as assignment of mouse models to orphan diseases and phenotypic clustering for pathways. We report a unified system to integrate and compare observation data across experimental projects, disease databases, and clinical biobanks. The core object model (Observ-OM) comprises only four basic concepts to represent any kind of observation: Targets, Features, Protocols (and their Applications), and Values. An easy-to-use file format (Observ-TAB) employs Excel to represent individual and aggregate data in straightforward spreadsheets. The systems have been tested successfully on human biobank, genome-wide association studies, quantitative trait loci, model organism, and patient registry data using the MOLGENIS platform to quickly setup custom data portals. Our system will dramatically lower the barrier for future data sharing and facilitate integrated search across panels and species. All models, formats, documentation, and software are available for free and open source (LGPLv3) at http://www.observ-om.org.

  10. Recessive loci Pps-1 and OM differentially regulate PISTILLATA-1 and APETALA3-1 expression for sepal and petal development in Papaver somniferum.

    PubMed

    Singh, Sharad K; Shukla, Ashutosh K; Dhawan, Om P; Shasany, Ajit K

    2014-01-01

    The involvement of PISTILLATA (PI) and APETALA (AP) transcription factors in the development of floral organs has previously been elucidated but little is known about their upstream regulation. In this investigation, two novel mutants generated in Papaver somniferum were analyzed--one with partially petaloid sepals and another having sepaloid petals. Progeny from reciprocal crosses of respective mutant parent genotypes showed a good fit to the monogenic Mendelian inheritance model, indicating that the mutant traits are likely controlled by the single, recessive nuclear genes named "Pps-1" and "OM" in the partially petaloid sepal and sepaloid petal phenotypes, respectively. Both paralogs of PISTILLATA (PapsPI-1 and PapsPI-3) were obtained from the sepals and petals of P. somniferum. Ectopic expression of PapsPI-1 in tobacco resulted in a partially petaloid sepal phenotype at a low frequency. Upregulation of PapsPI-1 and PapsAP3-1 in the petal and the petal part of partially petaloid sepal mutant and down-regulation of the same in sepaloid petal mutant indicates a differential pattern of regulation for flowering-related genes in various whorls. Similarly, it was found that the recessive mutation OM in sepaloid petal mutant downregulates PapsPI-1 and PapsAP3-1 transcripts. The recessive nature of the mutations was confirmed by the segregation ratios obtained in this analysis.

  11. Cross Sections: No. 1 Hold section at Fr 24 Looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Cross Sections: No. 1 Hold section at Fr 24 Looking Fwd, No 1 Hold Section at Fr 28 Looking Aft, No 2 Hold Section at Fr 48 Looking Aft, No 3 Hold Section at Fr 70 Looking Aft, No 4 Hold Section at Fr 90 Looking Aft - General John Pope, Suisun Bay Reserve Fleet, Benicia, Solano County, CA

  12. 77 FR 49024 - Sai Wentum, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ..., 71 FR 39130, 39131 (2006); Dominick A. Ricci, 58 FR 51104, 51105 (1993); Bobby Watts, 53 FR 11919... practitioner has lost his state authority to dispense controlled substances. James L. Hooper, 76 FR...

  13. 75 FR 24785 - Employee Contribution Elections and Contribution Allocations; Methods of Withdrawing Funds From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... in the Federal Register of June 14, 2003 (68 FR 35492) and April 25, 2005 (70 FR 21290). As published... corrections were published in the Federal Register on June 14, 2003 (68 FR 35492) and April 25, 2005 (70 FR...

  14. OM85-BV Induced the Productions of IL-1β, IL-6, and TNF-α via TLR4- and TLR2-Mediated ERK1/2/NF-κB Pathway in RAW264.7 Cells

    PubMed Central

    Luan, Hong; Zhang, Qian; Wang, Le; Wang, Chuanxiao; Zhang, Miao; Xu, Xiaoli; Zhou, Huan; Li, Xing'ai; Xu, Qing; He, Fan

    2014-01-01

    Broncho-Vaxom (OM85-BV) is an extract mixture from 8 strains of Gram+ and Gram− bacteria and plays an important role in anti-infection immune response by regulating macrophage activity and cytokine productions. However, the mechanism by which OM85-BV enhances the cytokine expression is still obscure. In this study, we evaluated the effects of OM85-BV on the productions of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in RAW264.7 murine macrophages. Exposure of RAW264.7 cells to 100 μg/mL OM85-BV upregulated the expression of IL-1β, IL-6, and TNF-α at the mRNA and protein levels in a time- and dose-dependent manner. In addition, OM85-BV induced extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappa B (NF-κB) phosphorylation. Pretreatment with U0126 or Bay11-7082, respectively, could decrease IL-1β, IL-6, and TNF-α productions induced by OM85-BV. Application of Toll-like receptor (TLR) 4 or TLR2 small-interfering RNA (siRNA) into RAW264.7 cells could inhibit the productions of cytokines and ERK1/2 and NF-κB phosphorylation induced by OM85-BV. Consistent with this, downregulating either myeloid differentiation factor 88 (MyD88) or TRIF-related adaptor molecule (TRAM) gene with MyD88-siRNA or TRAM-siRNA separately could reduce the productions of cytokines and ERK1/2 and NF-κB phosphorylation induced by OM85-BV. Our study demonstrated that the productions of IL-1β, IL-6, and TNF-α induced by OM85-BV in RAW264.7 cells were through TLR4 and TLR2 signaling pathway-mediated activation of ERK1/2 and NF-κB. PMID:24605772

  15. OM85-BV induced the productions of IL-1β, IL-6, and TNF-α via TLR4- and TLR2-mediated ERK1/2/NF-κB pathway in RAW264.7 cells.

    PubMed

    Luan, Hong; Zhang, Qian; Wang, Le; Wang, Chuanxiao; Zhang, Miao; Xu, Xiaoli; Zhou, Huan; Li, Xing'ai; Xu, Qing; He, Fan; Yuan, Jin; Lv, Yongman

    2014-07-01

    Broncho-Vaxom (OM85-BV) is an extract mixture from 8 strains of Gram(+) and Gram(-) bacteria and plays an important role in anti-infection immune response by regulating macrophage activity and cytokine productions. However, the mechanism by which OM85-BV enhances the cytokine expression is still obscure. In this study, we evaluated the effects of OM85-BV on the productions of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in RAW264.7 murine macrophages. Exposure of RAW264.7 cells to 100 μg/mL OM85-BV upregulated the expression of IL-1β, IL-6, and TNF-α at the mRNA and protein levels in a time- and dose-dependent manner. In addition, OM85-BV induced extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappa B (NF-κB) phosphorylation. Pretreatment with U0126 or Bay11-7082, respectively, could decrease IL-1β, IL-6, and TNF-α productions induced by OM85-BV. Application of Toll-like receptor (TLR) 4 or TLR2 small-interfering RNA (siRNA) into RAW264.7 cells could inhibit the productions of cytokines and ERK1/2 and NF-κB phosphorylation induced by OM85-BV. Consistent with this, downregulating either myeloid differentiation factor 88 (MyD88) or TRIF-related adaptor molecule (TRAM) gene with MyD88-siRNA or TRAM-siRNA separately could reduce the productions of cytokines and ERK1/2 and NF-κB phosphorylation induced by OM85-BV. Our study demonstrated that the productions of IL-1β, IL-6, and TNF-α induced by OM85-BV in RAW264.7 cells were through TLR4 and TLR2 signaling pathway-mediated activation of ERK1/2 and NF-κB.

  16. Prospective, randomized comparison of OM-85 BV and a prophylactic antibiotic in children with recurrent infections and immunoglobulin A and/or G subclass deficiency☆

    PubMed Central

    Genel, Ferah; Kutukculer, Necil

    2003-01-01

    Background Patients with immunoglobulin (Ig)A and/or IgG subclass deficiency may be asymptomatic or may have recurrent, mainly respiratory infections. Objective This study compared the clinical efficacy and tolerability of prophylactic therapy with either the oral immunomodulator bacterial extract OM-85 BV or benzathine penicillin G (BPG) in the prevention of recurrent infections in symptomatic patients. Methods In this 26-month, prospective, randomized study conducted at the Department of Pediatric Immunology, Ege University (Izmir, Turkey), children aged 1 to 12 years with recurrent infections and IgA and/or IgG subclass deficiency were enrolled. After an initial 12-month control period, patients were randomized to receive OM-85 BV or BPG. OM-85 BV (3.5-mg capsule) was given once daily for the first 10 days of each month for the first 3 months of the study. IM injections of BPG were given at a dose of 1.2 million units (for patients with body weight > 27 kg) or at a half-dose (for patients with body weight ≤27 kg) every 3 weeks for 12 months. In nonresponders (ie, those who continued to have recurrent infections at 12-month follow-up), IV immunoglobulin (IVIG) replacement therapy at 400 mg/kg body weight was given every 4 weeks for an additional 12 months. The results of IVIG therapy were assessed by the authors using clinical observation. Adverse effects and adverse drug reactions were documented by the authors for each vaccine, prophylactic therapy, and IVIG. Results A total of 91 children (56 boys, 35 girls; mean [SD] age at the start of the control period, 46.4 [31.0] months) were enrolled. Of these, 44 were randomized to the OM-85 BV group and 47 to the BPG group. The year before prophylactic therapy, the mean (SD) number of reported infections was 10.7 (3.6) and the mean (SD) number of antibiotic courses was 9.7 (3.6) (OM-85 BV group: mean [SD] number of reported infections, 10.5 [3.3]; mean (SD) number of antibiotic courses, 9.3 [3.3]; BPG group: mean

  17. 77 FR 71592 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... Investments Held for an Extended Period. Agency form number: FR Y-12, FR Y12A, respectively. OMB control number: 7100-0300. Frequency: FR Y-12: quarterly or semi-annually, FR Y-12A: annually. Reporters: Bank...). Estimated annual reporting hours: FR Y-12: 2,112 hours, FR Y-12A: 126 hours. Estimated average hours...

  18. 75 FR 47540 - Extension of the Award Period for Certain Minority Business Enterprise Centers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Beach MSA. Mississippi MBEC Arkansas Regional State of Mississippi.... 71 FR 42351, as amended by 71 FR.../ 71 FR 42351, as amended by 74 FR 58246. Arlington MSA. El Paso MBEC El Paso Hispanic Chamber El Paso MSA 72 FR 71621, as amended by 74 FR 58246. of Commerce. New Mexico MBEC NEDA Business State of...

  19. The development and psychometric properties of a new scale to measure mental illness related stigma by health care providers: the Opening Minds Scale for Health Care Providers (OMS-HC).

    PubMed

    Kassam, Aliya; Papish, Andriyka; Modgill, Geeta; Patten, Scott

    2012-06-13

    Research on the attitudes of health care providers towards people with mental illness has repeatedly shown that they may be stigmatizing. Many scales used to measure attitudes towards people with mental illness that exist today are not adequate because they do not have items that relate specifically to the role of the health care provider. We developed and tested a new scale called the Opening Minds Scale for Health Care Providers (OMS-HC). After item-pool generation, stakeholder consultations and content validation, focus groups were held with 64 health care providers/trainees and six people with lived experience of mental illness to develop the scale. The OMS-HC was then tested with 787 health care providers/trainees across Canada to determine its psychometric properties. The initial testing OMS-HC scale showed good internal consistency, Cronbach's alpha = 0.82 and satisfactory test-retest reliability, intraclass correlation = 0.66 (95% CI 0.54 to 0.75). The OMC-HC was only weakly correlated with social desirability, indicating that the social desirability bias was not likely to be a major determinant of OMS-HC scores. A factor analysis favoured a two-factor structure which accounted for 45% of the variance using 12 of the 20 items tested. The OMS-HC provides a good starting point for further validation as well as a tool that could be used in the evaluation of programs aimed at reducing mental illness related stigma by health care providers. The OMS-HC incorporates various dimensions of stigma with a modest number of items that can be used with busy health care providers.

  20. Experimental immunization with anti-rheumatic bacterial extract OM-89 induces T cell responses to heat shock protein (hsp)60 and hsp70; modulation of peripheral immunological tolerance as its possible mode of action in the treatment of rheumatoid arthritis (RA)

    PubMed Central

    BLOEMENDAL, A; VAN DER ZEE, R; RUTTEN, V P M G; VAN KOOTEN, P J S; FARINE, J C; VAN EDEN, W

    1997-01-01

    OM-89 is a bacterial (Escherichia coli) extract used for oral administration in the treatment of RA. Given the evidence that immunity to bacterial heat shock antigens plays a critical role in the immunomodulation of arthritis and possibly inflammation in general, the purpose of the present studies was to evaluate the presence and immunogenicity of hsp in OM-89. Furthermore, we studied the effects of OM-89 in an experimental arthritis, where hsp are known to have a critical significance in disease development. In rats immunization with OM-89 was found to lead to proliferative T cell responses to hsp60 and hsp70 of both E. coli and mycobacterial origin. Conversely, immunization with hsp antigens was also found to induce T cell reactivity specific for OM-89. Based on this and the antigen specificity analysis of specific T cell lines, hsp70 (DnaK) turned out to be one of the major immunogenic constituents of OM-89. Parenteral immunization with OM-89 was found to reduce resistance to adjuvant arthritis (AA), whereas oral administration was found to protect against AA. Given the arthritis-inhibitory effect of oral OM-89 in AA, it is possible that peripheral tolerance is induced at the level of regulatory T cells with specificity for hsp. This may also constitute a mode of action for OM-89 as an arthritis-suppressive oral drug. PMID:9353151

  1. Engineering description of the OMS/RCS/DAP modes used in the HP-9825A High Fidelity Relative Motion Program (HFRMP)

    NASA Technical Reports Server (NTRS)

    Wilson, S. W.

    1978-01-01

    Simplified mathematical models are reported for the space shuttle's Orbital Maneuvering System (OMS), Reaction Control System (RCS), and on-orbit Digital Autopilot (DAP) that have been incorporated in the High-Fidelity Relative Motion Program (HFRMP) for the HP-9825A desk-top calculator. Comparisons were made between data generated by the HFRMP and by the Space Shuttle Functional Simulator (SSFS), which models the cited shuttle systems in much greater detail. These data include propellant requirements for representative translational maneuvers, rotational maneuvers, and attitude maintenance options. Also included are data relating to on-orbit trajectory deviations induced by RCS translational cross coupling. Potential close-range stationkeeping problems that are suggested by HFRMP simulations of 80 millisecond (as opposed to 40 millisecond) DAP cycle effects are described. The principal function of the HFRMP is to serve as a flight design tool in the area of proximity operations.

  2. a Study of Om-Cvd Processes for GALLIUM(1-X)INDIUM(X)ARSENIDE Growth on Gallium-Arsenide Substrates.

    NASA Astrophysics Data System (ADS)

    Kim, Myung Kul

    This work investigates OM-CVD growth processes of Ga(,l-x)In(,x)As. The motivation for this work has been the eventual application of this material in two-junction, cascaded solar cells. The growths were made using trimethylgallium, triethylindium and arsine and growths have been done on GaAs substrates. An attempt has been made to understand the growth process itself, and a possible mechanism for the growth process is proposed to explain the observations made in many aspects of crystal growth by OM-CVD. Heterogeneous catalysis of AsH(,3) on GaAs is viewed as providing a key step in understanding the growth mechanism. The growth of GaInAs on GaAs is interpreted in terms of an interfacial interaction between the grown layer and the substrate. The growth of InAs is found to be difficult on GaAs due to the large lattice mismatch. As the InAs composition is decreased, a coherent interface appears to be reached below an InAs composition of around 30-40%, where the growth displays single crystal epitaxy. The growth rate of GaInAs on GaAs is found to be more complicated than that for the lattice-matched situation of AlGaAs growth on the same GaAs substrate. Also, introduction of lattice strain appears to make the growth rate smaller than in the strain-free case. Growth of GaInAs on GaAs substrates of different orientations shows that good epitaxial growth with low defect densities can be obtained by some combinations of (100) and (111) faces. It is argued that the excellent epitaxial growth observed on the (511) surface should be on the "B" face by considering predicted growth behaviors on basic planes combined with the crystal growth mechanism of OM-CVD proposed. Background doping concentrations of layers grown by OM-CVD are found to be a strong function of source material purity as concluded by other workers. It is also found that incorporation of group II and group VI dopants decreaes with increasing growth temperature in contrast to group IV impurities, namely, C and

  3. Orientational order parameter, S, in N-(p-n-ethoxy benzylidene)-p-n-alkoxy anilines, 2O.Om LC compounds

    NASA Astrophysics Data System (ADS)

    Sastry, P. S.; Srinivasu, Ch.; Pardhasaradhi, P.; Pisipati, V. G. K. M.

    2016-01-01

    The orientational order parameter, S, is estimated in N-(p-n-ethoxy benzylidene)-p-n-alkoxy anilines, 2O.Om liquid crystalline (LC) compounds with alkoxy chain number, m = 3, 4, and 6-10 using four different methods. The methods employed are (1) from birefringence, ? where ne and no are extraordinary and ordinary refractive indices, (2) from effective geometry parameter, αg, where α = no/ne, (3) from the Haller approximation (1 - T/TNIβ where β is obtained from method (1), and (4) the Maier and Saupe method from density. In the four methods proposed no field is chosen to explain the nematic liquid crystal and provides the S values obtained are identical to one another except in the case of 2O.O9 compound where the S values are higher when compared to the others. All the methods are explained in detail.

  4. Beetle and plant arrow poisons of the Ju|’hoan and Hai||om San peoples of Namibia (Insecta, Coleoptera, Chrysomelidae; Plantae, Anacardiaceae, Apocynaceae, Burseraceae)

    PubMed Central

    Chaboo, Caroline S.; Biesele, Megan; Hitchcock, Robert K.; Weeks, Andrea

    2016-01-01

    Abstract The use of archery to hunt appears relatively late in human history. It is poorly understood but the application of poisons to arrows to increase lethality must have occurred shortly after developing bow hunting methods; these early multi-stage transitions represent cognitive shifts in human evolution. This paper is a synthesis of widely-scattered literature in anthropology, entomology, and chemistry, dealing with San (“Bushmen”) arrow poisons. The term San (or Khoisan) covers many indigenous groups using so-called ‘click languages’ in southern Africa. Beetles are used for arrow poison by at least eight San groups and one non-San group. Fieldwork and interviews with Ju|’hoan and Hai||om hunters in Namibia revealed major differences in the nature and preparation of arrow poisons, bow and arrow construction, and poison antidote. Ju|’hoan hunters use leaf-beetle larvae of Diamphidia Gerstaecker and Polyclada Chevrolat (Chrysomelidae: Galerucinae: Alticini) collected from soil around the host plants Commiphora africana (A. Rich.) Engl. and Commiphora angolensis Engl. (Burseracaeae). In the Nyae Nyae area of Namibia, Ju|’hoan hunters use larvae of Diamphidia nigroornata Ståhl. Larvae and adults live above-ground on the plants and eat leaves, but the San collect the underground cocoons to extract the mature larvae. Larval hemolymph is mixed with saliva and applied to arrows. Hai||om hunters boil the milky plant sap of Adenium bohemianum Schinz (Apocynaceae) to reduce it to a thick paste that is applied to their arrows. The socio-cultural, historical, and ecological contexts of the various San groups may determine differences in the sources and preparation of poisons, bow and arrow technology, hunting behaviors, poison potency, and perhaps antidotes. PMID:27006594

  5. Beetle and plant arrow poisons of the Ju|'hoan and Hai||om San peoples of Namibia (Insecta, Coleoptera, Chrysomelidae; Plantae, Anacardiaceae, Apocynaceae, Burseraceae).

    PubMed

    Chaboo, Caroline S; Biesele, Megan; Hitchcock, Robert K; Weeks, Andrea

    2016-01-01

    The use of archery to hunt appears relatively late in human history. It is poorly understood but the application of poisons to arrows to increase lethality must have occurred shortly after developing bow hunting methods; these early multi-stage transitions represent cognitive shifts in human evolution. This paper is a synthesis of widely-scattered literature in anthropology, entomology, and chemistry, dealing with San ("Bushmen") arrow poisons. The term San (or Khoisan) covers many indigenous groups using so-called 'click languages' in southern Africa. Beetles are used for arrow poison by at least eight San groups and one non-San group. Fieldwork and interviews with Ju|'hoan and Hai||om hunters in Namibia revealed major differences in the nature and preparation of arrow poisons, bow and arrow construction, and poison antidote. Ju|'hoan hunters use leaf-beetle larvae of Diamphidia Gerstaecker and Polyclada Chevrolat (Chrysomelidae: Galerucinae: Alticini) collected from soil around the host plants Commiphora africana (A. Rich.) Engl. and Commiphora angolensis Engl. (Burseracaeae). In the Nyae Nyae area of Namibia, Ju|'hoan hunters use larvae of Diamphidia nigroornata Ståhl. Larvae and adults live above-ground on the plants and eat leaves, but the San collect the underground cocoons to extract the mature larvae. Larval hemolymph is mixed with saliva and applied to arrows. Hai||om hunters boil the milky plant sap of Adenium bohemianum Schinz (Apocynaceae) to reduce it to a thick paste that is applied to their arrows. The socio-cultural, historical, and ecological contexts of the various San groups may determine differences in the sources and preparation of poisons, bow and arrow technology, hunting behaviors, poison potency, and perhaps antidotes.

  6. 78 FR 16894 - In the Matter of Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Units 1 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... notice that was published in the Federal Register (FR) on March 5, 2013 (78 FR 14361), regarding the....Bladey@nrc.gov . Correction In the FR of March 5, 2013, in FR Doc. 2013-05021, on page 14362,...

  7. 76 FR 68127 - Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ...] [FR Doc No: 2011-28540] ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular...

  8. Actinide Oxidation State and O/M Ratio in Hypostoichiometric Uranium-Plutonium-Americium U0.750Pu0.246Am0.004O2-x Mixed Oxides.

    PubMed

    Vauchy, Romain; Belin, Renaud C; Robisson, Anne-Charlotte; Lebreton, Florent; Aufore, Laurence; Scheinost, Andreas C; Martin, Philippe M

    2016-03-07

    Innovative americium-bearing uranium-plutonium mixed oxides U1-yPuyO2-x are envisioned as nuclear fuel for sodium-cooled fast neutron reactors (SFRs). The oxygen-to-metal (O/M) ratio, directly related to the oxidation state of cations, affects many of the fuel properties. Thus, a thorough knowledge of its variation with the sintering conditions is essential. The aim of this work is to follow the oxidation state of uranium, plutonium, and americium, and so the O/M ratio, in U0.750Pu0.246Am0.004O2-x samples sintered for 4 h at 2023 K in various Ar + 5% H2 + z vpm H2O (z = ∼ 15, ∼ 90, and ∼ 200) gas mixtures. The O/M ratios were determined by gravimetry, XAS, and XRD and evidenced a partial oxidation of the samples at room temperature. Finally, by comparing XANES and EXAFS results to that of a previous study, we demonstrate that the presence of uranium does not influence the interactions between americium and plutonium and that the differences in the O/M ratio between the investigated conditions is controlled by the reduction of plutonium. We also discuss the role of the homogeneity of cation distribution, as determined by EPMA, on the mechanisms involved in the reduction process.

  9. 76 FR 63177 - Airworthiness Directives; Airbus Model A300 B2-1C, A300 B2-203, A300 B2K-3C, A300-B4-103, A300 B4...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... and RH (FR54 3,600 flight cycles. through FR58). All STGR22 LH and RH 2,700 flight cycles. (FR26 through FR40). All STGR22 RH (FR58 3,000 flight cycles. through FR65). All STGR31 LH/RH (FR26 3,000 flight cycles. through FR39). MSN 0003 STGR31 LH/RH (FR54 3,600 flight cycles. through FR58). (h) For airplanes...

  10. 75 FR 21963

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Title Identifier Number Number 432 Rule 15c2-2: Confirmation of Transactions in Open-End Management... Education Savings 433 Rule 15c2-3: Point-of-Sale Disclosure of Purchases in Open-End Management Investment... NPRM 07/17/09 74 FR 35076 NPRM Comment Period End 09/15/09 Final Action 12/23/09 74 FR 68334 ]...

  11. The development and psychometric properties of a new scale to measure mental illness related stigma by health care providers: The opening minds scale for Health Care Providers (OMS-HC)

    PubMed Central

    2012-01-01

    Background Research on the attitudes of health care providers towards people with mental illness has repeatedly shown that they may be stigmatizing. Many scales used to measure attitudes towards people with mental illness that exist today are not adequate because they do not have items that relate specifically to the role of the health care provider. Methods We developed and tested a new scale called the Opening Minds Scale for Health Care Providers (OMS-HC). After item-pool generation, stakeholder consultations and content validation, focus groups were held with 64 health care providers/trainees and six people with lived experience of mental illness to develop the scale. The OMS-HC was then tested with 787 health care providers/trainees across Canada to determine its psychometric properties. Results The initial testing OMS-HC scale showed good internal consistency, Cronbach’s alpha = 0.82 and satisfactory test-retest reliability, intraclass correlation = 0.66 (95% CI 0.54 to 0.75). The OMC-HC was only weakly correlated with social desirability, indicating that the social desirability bias was not likely to be a major determinant of OMS-HC scores. A factor analysis favoured a two-factor structure which accounted for 45% of the variance using 12 of the 20 items tested. Conclusions The OMS–HC provides a good starting point for further validation as well as a tool that could be used in the evaluation of programs aimed at reducing mental illness related stigma by health care providers. The OMS-HC incorporates various dimensions of stigma with a modest number of items that can be used with busy health care providers. PMID:22694771

  12. Sequence analysis and characterization of pOM1, a small cryptic plasmid from Butyrivibrio fibrisolvens, and its use in construction of a new family of cloning vectors for Butyrivibrios.

    PubMed Central

    Hefford, M A; Kobayashi, Y; Allard, S E; Forster, R J; Teather, R M

    1997-01-01

    As a preliminary step in the development of vector systems, we have isolated and begun to characterize small, cryptic plasmids from several strains of the rumen bacterium Butyrivibrio fibrisolvens. We present here the complete nucleotide sequence of Butyrivibrio plasmid pOM1, which was isolated from B. fibrisolvens Bu49. While it is very similar in size to the previously characterized Butyrivibrio plasmids pRJF1 and pRJF2, pOM1 exhibits a restriction pattern which is quite distinct. Analysis of sequence data reveals that pOM1 contains only two open reading frames of significant length (ORF1 and ORF2), both of which are required for self-replication and maintenance. The protein encoded in ORF1 shows homologies with Pre (plasmid recombination enzyme) proteins encoded in plasmids from gram-positive organisms such as Staphylococcus aureus, Streptococcus agalactiae, Lactobacillus plantarum, and Bacillus thuringiensis. The putative translation product of ORF2, on the other hand, resembles Rep (replication) proteins of a different group of gram-positive plasmids, for which the Staphylococcus plasmid pSN2 is a prototype. Unlike the other characterized-Butyrivibrio plasmids, pOM1 appears to replicate via a rolling-circle mechanism. Experimental evidence showing the presence of a single-stranded replication intermediate consistent with this mechanism is presented. pOM1 has been used in the construction of a new Escherichia coli-B. fibrisolvens shuttle vector, pSMerm1, which has been successfully used to introduce a cloned gene into B. fibrisolvens harboring the pRJF1 plasmid. PMID:9143105

  13. 75 FR 2560 - Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    .... 217648 U.S. Fish and Wildlife 74 FR 37240, July 28, December 8, 2009 Service. 2009. 222610 Atlanta-Fulton.... Pylman....... 74 FR 58977; November December 23, 2009 16, 2009. 231522 Robert B. Spencer...... 74...

  14. Hierarchically multifunctional K-OMS-2/TiO2/Fe3O4 heterojunctions for the photocatalytic oxidation of humic acid under solar light irradiation.

    PubMed

    Zhang, Tong; Yan, Xiaoli; Sun, Darren Delai

    2012-12-01

    A multifunctional heterojunctioned K-OMS-2/TiO(2)/Fe(3)O(4) (KTF) nanocomposite was successfully synthesized using a combination of hydrothermal and co-precipitation techniques. The resultant sample was characterized by XRD, FESEM, TEM, N(2) adsorption, XPS and VSM. Its photocatalytic activity was demonstrated in the photocatalytic degradation of humic acid (HA). Morphology characterization showed the hierarchical structure of the synthesized material, and XRD results revealed that both the rutile and anatase TiO(2) structures are present in the sample. The average pore diameters and BET surface area of the synthesized KTF heterojunctions were 40 nm and 134.42 m(2)/g, respectively. XPS spectra confirmed the presence of Fe(3)O(4) and TiO(2) in the synthesized material, and the valences of Mn were kept at +3 and +4 after the grafting of Fe(3)O(4) and TiO(2). The synthesized material showed good magnetic response and photocatalytic activity under simulated solar light irradiation, and 85.7% of HA was decomposed after 120 min in the presence of KTF nanocomposites. The reusability study suggested that the magnetic recovered material was stable enough for multiple recycling usages, verifying its potential application in water purification. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Recessive Loci Pps-1 and OM Differentially Regulate PISTILLATA-1 and APETALA3-1 Expression for Sepal and Petal Development in Papaver somniferum

    PubMed Central

    Singh, Sharad K.; Shukla, Ashutosh K.; Dhawan, Om P.; Shasany, Ajit K.

    2014-01-01

    The involvement of PISTILLATA (PI) and APETALA (AP) transcription factors in the development of floral organs has previously been elucidated but little is known about their upstream regulation. In this investigation, two novel mutants generated in Papaver somniferum were analyzed - one with partially petaloid sepals and another having sepaloid petals. Progeny from reciprocal crosses of respective mutant parent genotypes showed a good fit to the monogenic Mendelian inheritance model, indicating that the mutant traits are likely controlled by the single, recessive nuclear genes named “Pps-1” and “OM” in the partially petaloid sepal and sepaloid petal phenotypes, respectively. Both paralogs of PISTILLATA (PapsPI-1 and PapsPI-3) were obtained from the sepals and petals of P. somniferum. Ectopic expression of PapsPI-1 in tobacco resulted in a partially petaloid sepal phenotype at a low frequency. Upregulation of PapsPI-1 and PapsAP3-1 in the petal and the petal part of partially petaloid sepal mutant and down-regulation of the same in sepaloid petal mutant indicates a differential pattern of regulation for flowering-related genes in various whorls. Similarly, it was found that the recessive mutation OM in sepaloid petal mutant downregulates PapsPI-1 and PapsAP3-1 transcripts. The recessive nature of the mutations was confirmed by the segregation ratios obtained in this analysis. PMID:24979593

  16. A High Throughput, Whole Cell Screen for Small Molecule Inhibitors of the Mitotic Spindle Checkpoint Identifies OM137, a Novel Aurora Kinase Inhibitor

    PubMed Central

    DeMoe, Joanna H.; Santaguida, Stefano; Daum, John R.; Musacchio, Andrea; Gorbsky, Gary J.

    2008-01-01

    In mitosis the kinetochores of chromosomes that lack full microtubule attachments and/or mechanical tension activate a signaling pathway called the mitotic spindle checkpoint that blocks progression into anaphase and prevents premature segregation of the chromatids until chromosomes become aligned at the metaphase plate (1). The spindle checkpoint is responsible for arresting cells in mitosis in response to chemotherapeutic spindle poisons such as paclitaxel or vinblastine. Some cancer cells show a weakened checkpoint signaling system that may contribute to chromosome instability in tumors. Since complete absence of the spindle checkpoint leads to catastrophic cell division, we reasoned that drugs targeting the checkpoint might provide a therapeutic window in which the checkpoint would be eliminated in cancer cells but sufficiently preserved in normal cells. We developed an assay to identify lead compounds that inhibit the spindle checkpoint. Most cells respond to microtubule drugs by activating the spindle checkpoint and arresting in mitosis with a rounded morphology. Our assay depended on the ability of checkpoint inhibitor compounds to drive mitotic exit and cause cells to flatten onto the substrate in the continuous presence of microtubule drugs. In this study we characterize one of the compounds, OM137, as an inhibitor of Aurora kinases. We find that this compound is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel. PMID:19190331

  17. 78 FR 79292 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... corresponds to FAA AD 2007-14-01, Amendment 39-15123, (72 FR 38006, July 12, 2007)] to require compliance with... 2007-14-01, Amendment 39-15123, (72 FR 38006, July 12, 2007)] to require compliance with FAL specified... also adds new airplanes to the applicability of this AD. AD 2011-24-09 (76 FR 73486, November 29,...

  18. 76 FR 73496 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ...., Monday through Friday, except Federal holidays. The AD docket contains the NPRM (76 FR 42602, July 19... the fasteners installation in the junction keel beam fitting at FR 40, in accordance with Airbus... installation in the junction keel beam fitting at FR 40, in accordance with Airbus Service Bulletin...

  19. 75 FR 41233 - Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... Jarvis 75 FR 19656; April 15, June 4, 2010 2010. 080731 and 716917 George Carden Circus 75 FR 2561; January 15, July 1, 2010 International, Inc.. 2010. 070854, 079868, 079870, 079871, and George Carden Circus 75 FR 27814; May 18, July 1, 2010 079872. International, Inc.. 2010. 128999 and 12311A George...

  20. 77 FR 58556 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... by FR Y-12 or FR Y-12A, by any of the following methods: Agency Web Site: http://www.federalreserve... viewed electronically or in paper form in Room MP- 500 of the Board's Martin Building (20th and C Streets... Investments Held for an Extended Period. Agency form number: FR Y-12, FR Y12A, respectively. OMB...

  1. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

  2. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

  3. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

  4. 76 FR 44353 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... Permit No. Applicant Federal date Register notice 28080A St. John Fisher 76 FR 12990; June 16, 2011. College. March 9, 2011. 38879A Scott Ackleson.. 76 FR 27660; June 17, 2011. May 12, 2011. 44242A Larry Hildreth.. 76 FR 32223; July 05, 2011. June 3, 2011. 43070A Keith Jefferson. 76 FR 32223; July 12,...

  5. 78 FR 48712 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... 78 FR 9725; February 11, June 14, 2013. the University of 2013. Illinois. 675484 Birmingham Zoo, Inc..... 78 FR 16292; March 14, May 1, 2013. 2013. 036218 Brevard Zoo 78 FR 1771; March 22, May 1, 2013. 2013. 682781 Chicago Zoological 78 FR 1771; March 22, May 1, 2013. Society. 2013. 808265 Gary Johnson 78...

  6. 75 FR 79763 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... for the common cold. Timetable: Action Date FR Cite Reopening of Administrative Record 08/25/00 65 FR 51780 NPRM (Amendment) (Common Cold) 10/00/11 Regulatory Flexibility Analysis Required: Yes Agency... Plan Seq No. 45) 313 Over-the-Counter (OTC) Drug Review--Cough/Cold (Antihistamine) Products 0910-AF31...

  7. 75 FR 52376 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... [Federal Register Volume 75, Number 164 (Wednesday, August 25, 2010)] [Notices] [Pages 52376-52377] [FR Doc No: 2010-21069] OFFICE OF PERSONNEL MANAGEMENT Excepted Service AGENCY: U.S. Office of.... 218. John Berry, Director, U.S. Office of Personnel Management. [FR Doc. 2010-21069 Filed 8-24-10;...

  8. 75 FR 16153 - Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); and November 7, 2003 (68 FR 63098), December 7, 2005 (70 FR 72840). ] Proposed Substances To Be Evaluated for Set 24... BROMODICHLOROETHANE 000683-53-4 3 1,2,3-TRICHLOROBENZ 000087-61-6 ENE. 4 POLONIUM-210....... 013981-52-7 5 LEAD-210...

  9. 77 FR 24409 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... INFORMATION CONTACT: Erick Chuang, (410) 786-1816. SUPPLEMENTARY INFORMATION: I. Regulatory Overview In FR Doc. 2011-26812 of November 30, 2011 (76 FR 74122) and FR Doc. 2011-33751 of January 4, 2012 (77 FR 217... for payment in the claims year but did not meet the Medicare requirements for payment (76 FR...

  10. Mixotrophic growth of bacteriochlorophyll a-containing members of the OM60/NOR5 clade of marine gammaproteobacteria is carbon-starvation independent and correlates with the type of carbon source and oxygen availability

    PubMed Central

    2013-01-01

    Background Populations of aerobic anoxygenic photoheterotrophic bacteria in marine environments are dominated by members of the Roseobacter lineage within the Alphaproteobacteria and the OM60/NOR5 clade of gammaproteobacteria. A wealth of information exists about the regulation of pigment production and mixotrophic growth in various members of the Roseobacter clade, but a detailed knowledge about aerobic bacteriochlorophyll a-containing gammaproteobacteria is still limited to one strain of the species Congregibacter litoralis. Results The production of photosynthetic pigments and light-dependent mixotrophic growth was analysed in Luminiphilus syltensis DSM 22749T, Chromatocurvus halotolerans DSM 23344T and Pseudohaliea rubra DSM 19751T, representing three taxonomically diverse strains of bacteriochlorophyll a-containing gammaproteobacteria affiliated to the OM60/NOR5 clade. In these strains the expression of a photosynthetic apparatus depended mainly on the type of carbon source and availability of oxygen. The effect of illumination on pigment expression varied significantly between strains. In contrast to Chromatocurvus halotolerans, pigment production in Luminiphilus syltensis and Pseudohaliea rubra was repressed by light of moderate intensities, probably indicating a higher sensitivity to light-induced oxidative stress. The efficiency of using light for mixotrophic growth did not correlate with the cellular level of photosynthetic pigments, but depended mainly on the type of metabolized substrate with malate being the optimal carbon source in most cases. Conclusions Oligotrophic growth conditions or carbon limitation were not required for light-dependent mixotrophic growth in members of the OM60/NOR5 clade. The ability of using light as energy source and the fine tuning of photosynthesis gene expression depended mainly on the type of carbon source and oxygen availability, which indicates that the regulation of pigment production is controlled by the cellular

  11. Mixotrophic growth of bacteriochlorophyll a-containing members of the OM60/NOR5 clade of marine gammaproteobacteria is carbon-starvation independent and correlates with the type of carbon source and oxygen availability.

    PubMed

    Spring, Stefan; Riedel, Thomas

    2013-05-24

    Populations of aerobic anoxygenic photoheterotrophic bacteria in marine environments are dominated by members of the Roseobacter lineage within the Alphaproteobacteria and the OM60/NOR5 clade of gammaproteobacteria. A wealth of information exists about the regulation of pigment production and mixotrophic growth in various members of the Roseobacter clade, but a detailed knowledge about aerobic bacteriochlorophyll a-containing gammaproteobacteria is still limited to one strain of the species Congregibacter litoralis. The production of photosynthetic pigments and light-dependent mixotrophic growth was analysed in Luminiphilus syltensis DSM 22749T, Chromatocurvus halotolerans DSM 23344T and Pseudohaliea rubra DSM 19751T, representing three taxonomically diverse strains of bacteriochlorophyll a-containing gammaproteobacteria affiliated to the OM60/NOR5 clade. In these strains the expression of a photosynthetic apparatus depended mainly on the type of carbon source and availability of oxygen. The effect of illumination on pigment expression varied significantly between strains. In contrast to Chromatocurvus halotolerans, pigment production in Luminiphilus syltensis and Pseudohaliea rubra was repressed by light of moderate intensities, probably indicating a higher sensitivity to light-induced oxidative stress. The efficiency of using light for mixotrophic growth did not correlate with the cellular level of photosynthetic pigments, but depended mainly on the type of metabolized substrate with malate being the optimal carbon source in most cases. Oligotrophic growth conditions or carbon limitation were not required for light-dependent mixotrophic growth in members of the OM60/NOR5 clade. The ability of using light as energy source and the fine tuning of photosynthesis gene expression depended mainly on the type of carbon source and oxygen availability, which indicates that the regulation of pigment production is controlled by the cellular redox state. While light has the

  12. Structural Health and Prognostics Management for Offshore Wind Turbines: Sensitivity Analysis of Rotor Fault and Blade Damage with O&M Cost Modeling

    SciTech Connect

    Myrent, Noah J.; Barrett, Natalie C.; Adams, Douglas E.; Griffith, Daniel Todd

    2014-07-01

    Operations and maintenance costs for offshore wind plants are significantly higher than the current costs for land-based (onshore) wind plants. One way to reduce these costs would be to implement a structural health and prognostic management (SHPM) system as part of a condition based maintenance paradigm with smart load management and utilize a state-based cost model to assess the economics associated with use of the SHPM system. To facilitate the development of such a system a multi-scale modeling and simulation approach developed in prior work is used to identify how the underlying physics of the system are affected by the presence of damage and faults, and how these changes manifest themselves in the operational response of a full turbine. This methodology was used to investigate two case studies: (1) the effects of rotor imbalance due to pitch error (aerodynamic imbalance) and mass imbalance and (2) disbond of the shear web; both on a 5-MW offshore wind turbine in the present report. Sensitivity analyses were carried out for the detection strategies of rotor imbalance and shear web disbond developed in prior work by evaluating the robustness of key measurement parameters in the presence of varying wind speeds, horizontal shear, and turbulence. Detection strategies were refined for these fault mechanisms and probabilities of detection were calculated. For all three fault mechanisms, the probability of detection was 96% or higher for the optimized wind speed ranges of the laminar, 30% horizontal shear, and 60% horizontal shear wind profiles. The revised cost model provided insight into the estimated savings in operations and maintenance costs as they relate to the characteristics of the SHPM system. The integration of the health monitoring information and O&M cost versus damage/fault severity information provides the initial steps to identify processes to reduce operations and maintenance costs for an offshore wind farm while increasing turbine availability

  13. What Are the Omh^2 (z1, z2) and Om (z1, z2) Diagnostics Telling us in Light of H(z) Data?

    NASA Astrophysics Data System (ADS)

    Zheng, Xiaogang; Ding, Xuheng; Biesiada, Marek; Cao, Shuo; Zhu, Zong-Hong

    2016-07-01

    The two-point diagnostics Om(z i , z j ) and Omh 2(z i , z j ) have been introduced as an interesting tool for testing the validity of the Λ cold dark matter (ΛCDM) model. Recently, Sahni et al. combined two independent measurements of H(z) from baryon acoustic oscillation (BAO) data with the value of the Hubble constant H 0, and used the second of these diagnostics to test the ΛCDM (a constant equation-of-state parameter for dark energy) model. Their result indicated a considerable tension between observations and predictions of the ΛCDM model. Since reliable data concerning the expansion rates of the universe at different redshifts H(z) are crucial for the successful application of this method, we investigate both two-point diagnostics on the most comprehensive set of N = 36 measurements of H(z) from BAOs and the differential ages (DAs) of passively evolving galaxies. We discuss the uncertainties of the two-point diagnostics and find that they are strongly non-Gaussian and follow the patterns deeply rooted in their very construction. Therefore we propose that non-parametric median statistics is the most appropriate way of treating this problem. Our results support the claims that ΛCDM is in tension with H(z) data according to the two-point diagnostics developed by Shafieloo, Sahni, and Starobinsky. However, other alternatives to the ΛCDM model, such as the wCDM or Chevalier-Polarski-Linder models, perform even worse. We also note that there are serious systematic differences between the BAO and DA methods that ought to be better understood before H(z) measurements can compete with other probes methods.

  14. Single photon ionization of van der Waals clusters with a soft x-ray laser: (CO2)n and (CO2)n(H2O)m

    NASA Astrophysics Data System (ADS)

    Heinbuch, S.; Dong, F.; Rocca, J. J.; Bernstein, E. R.

    2006-10-01

    Pure neutral (CO2)n clusters and mixed (CO2)n(H2O)m clusters are investigated employing time of flight mass spectroscopy and single photon ionization at 26.5eV. The distribution of pure (CO2)n clusters decreases roughly exponentially with increasing cluster size. During the ionization process, neutral clusters suffer little fragmentation because almost all excess cluster energy above the vertical ionization energy is taken away by the photoelectron and only a small part of the photon energy is deposited into the (CO2)n cluster. Metastable dissociation rate constants of (CO2)n+ are measured in the range of (0.2-1.5)×104s-1 for cluster sizes of 5⩽n⩽16. Mixed CO2-H2O clusters are studied under different generation conditions (5% and 20% CO2 partial pressures and high and low expansion pressures). At high CO2 concentration, predominant signals in the mass spectrum are the (CO2)n + cluster ions. The unprotonated cluster ion series (CO2)nH2O+ and (CO2)n(H2O)2+ are also observed under these conditions. At low CO2 concentration, protonated cluster ions (H2O)nH+ are the dominant signals, and the protonated CO2(H2O)nH+ and unprotonated (H2O)n+ and (CO2)(H2O)n+ cluster ion series are also observed. The mechanisms and dynamics of the formation of these neutral and ionic clusters are discussed.

  15. Determination of OM/OC ratios and specific attenuation coefficients (SAC) in ambient fine PM at a rural site in southern Ontario: implications for emission sources, particle aging, and radiative forcing

    NASA Astrophysics Data System (ADS)

    Chan, T. W.; Huang, L.; Leaitch, W. R.; Sharma, S.; Brook, J. R.; Slowik, J. G.; Abbatt, J. P. D.; Brickell, P. C.; Liggio, J.; Li, S.-M.; Moosmüller, H.

    2009-07-01

    Ambient particulate matter (PM) samples were collected on quartz filters at a rural site in southern Ontario during intensive studies in 2005 and 2007. The concentrations of organic carbon (OC), pyrolysis organic carbon (POC), and elemental carbon (EC) were determined by thermal analysis. These results were compared to the organic aerosol mass concentration (OM) measured by an Aerodyne Aerosol Mass Spectrometer (AMS) and to the particle absorption coefficient (b_asp) obtained from a Radiance Research Particle Soot Absorption Photometer (PSAP). The total organic mass to organic carbon ratios (OM/OC) and specific attenuation coefficients (SAC) were also derived. According to the results, the POC mass is proportional to the approximated oxygen mass in the aerosols and OM/OC ratios can be estimated directly from thermal measurements. The study also suggests that the air masses from the south, with relatively low OC/EC ratios, high EC, sulphate contents and OM/OC ratios, were originated from urban and industrial emissions and subsequently experienced photo-oxidations in the atmosphere, implying that the oxygenated organics could come from both primary and secondary sources. Whereas the air masses from the north, with relatively high OC/EC ratios, low EC, sulphate contents and OM/OC ratios, were dominant by the background clean air with relatively larger contributions from biogenic emissions. The mean SAC derived from the 2005 and 2007 studies are 4.9 m2 g-1 and 3.8 m2 g-1, respectively. When POC mass approaching zero (i.e. the impact of atmospheric aging is minimized), the SAC for primary emitted soot is estimated to be 5.8 m2 g-1 and 6.3 m2 g-1 for the northern and southern air masses, respectively, supported by the corresponding values when particulate sulphate concentration approaches zero. A decreasing trend in the SAC value with atmospheric aging of the aerosol was observed at the site, suggesting that during the study, the light absorption enhancement due to the

  16. 75 FR 38061 - Airworthiness Directives; Airbus Model A300 B4-600 Series Airplanes; Model A300 B4-600R Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... reinforcement of the junction of frame bases at FR48, FR49 and FR51 to FR53 is necessary to enable the aircraft... (42 500 FC ), it has been concluded that a reinforcement of the junction of frame bases at FR48, FR49... above, this AD requires the reinforcement of the affected junction of frame bases. Required...

  17. 75 FR 61975 - Airworthiness Directives; Airbus Model A300 B4-600 Series Airplanes, Model A300 B4-600R Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... a reinforcement of the junction of frame bases at FR48, FR49 and FR51 to FR53 is necessary to enable... (42,500 FC ), it has been concluded that a reinforcement of the junction of frame bases at FR48, FR49... above, this AD requires the reinforcement of the affected junction of frame bases. Required...

  18. 76 FR 58269 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... procedures prescribed in 5 CFR 1320.12. On May 9, 2011 (76 FR 26900), EPA sought comments on this ICR... Manufacturing were proposed on October 4, 2001 (66 FR 50768), and promulgated on October 18, 2002 (67 FR...

  19. 75 FR 14441 - General Services Administration; Office of Governmentwide Policy; Submission for Review; Tangible...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... Register at 72 FR 64648, November 16, 2007 and 73 FR 67175, November 13, 2008. Comments were received... over specific reporting requirements in the provisions of existing awards. The response in 73 FR...

  20. Quadrupole moments of high spin isomers in sup 213 Fr, sup 212 Fr, and sup 211 Fr

    SciTech Connect

    Hardeman, F.; Neyens, G.; Scheveneels, G.; Nouwen, R.; S'heeren, G.; Van Den Bergh, M.; Coussement, R. ); Byrne, A.P.; Muesseler, R.; Huebel, H.; Baldsiefen, G. )

    1991-02-01

    The level mixing spectroscopy method has been applied to measure the static quadrupole moments of six isomeric states in {sup 213}Fr, {sup 212}Fr, and {sup 211}Fr ({ital Z}=87). For isomers with the proton configuration {pi}{ital h}{sub 9/2}{sup 4}{ital i}{sub 13/2} a large increase of the quadrupole moment was observed with the removal of neutrons from the closed {ital N}=126 core: {ital Q}(29/2{sup +},{sup 213}Fr)={minus}70(7) {ital e} fm{sup 2}, {ital Q}(15{sup {minus}},{sup 212}Fr)={minus}80(12) {ital e} fm{sup 2}, and {ital Q}(29/2{sup +},{sup 211}Fr)={minus}107(18) {ital e} fm{sup 2}. Quadrupole moments for very high spin states were also measured: {ital Q}(65/2{sup {minus}},{sup 213}Fr)={minus}219(53) {ital e} fm{sup 2}, {ital Q}(27{sup {minus}},{sup 212}Fr)={minus}152(31) {ital e} fm{sup 2}, and {ital Q}(45/2{sup {minus}},{sup 211}Fr) ={minus}198(56) {ital e} fm{sup 2}. The observed values are in good agreement with shell-model calculations, but are lower than that predicted using the deformed-independent particle model. The implantation behavior of Fr in a Tl host is also discussed.

  1. B Vitamin and/or n-3 Fatty Acid Supplementation and Health-Related Quality of Life: Ancillary Findings from the SU.FOL.OM3 Randomized Trial

    PubMed Central

    Andreeva, Valentina A.; Latarche, Clotilde; Hercberg, Serge; Briançon, Serge; Galan, Pilar; Kesse-Guyot, Emmanuelle

    2014-01-01

    Background Despite growing attention to nutrition and quality of life in cardiovascular disease survivors, the impact of dietary factors according to disease type or to quality of life domain is poorly understood. We investigated the effects of B vitamin and/or n-3 fatty acid supplementation on health-related quality of life among survivors of stroke, myocardial infarction, or unstable angina. Methods We performed ancillary analyses of the SU.FOL.OM3 trial (2003–2009; France). In total, 2,501 men (mean age = 61 y) and women (mean age = 63 y) were randomized in a 2×2 factorial design to: 1) 0.56 mg 5-methyl-tetrahydrofolate, 3 mg vitamin B6, 0.02 mg vitamin B12; 2) 600 mg eicosapentaenoic and docosahexaenoic acids in a 2∶1 ratio; 3) B vitamins and n-3 fatty acids combined; or 4) placebo. Health-related quality of life was evaluated at follow-up with the Medical Outcomes Study 36-Item Short Form Health Survey. Data from 2,029 individuals were used in this analysis. Results After 3.1±0.4 y, no effects of supplementation with either B vitamins or n-3 fatty acids on quality of life (physical or mental health domains) were found. However, participants receiving B vitamins had slightly more activity limitations due to emotional problems compared with those not receiving B vitamins (mean difference = 3.8; 95% CI: 0.4, 7.1). A significant interaction of treatment by prior disease revealed an inverse association between n-3 fatty acids and vitality among myocardial infarction survivors (mean difference = 2.9; 95% CI: 0.5, 5.2). Conclusions There were no beneficial effects of supplementation with relatively low doses of B vitamins or n-3 fatty acids on health-related quality of life in cardiovascular disease survivors. The adverse effects of B vitamins on activity limitations and of n-3 fatty acids on vitality among individuals with prior myocardial infarction merit confirmation. PMID:24465438

  2. B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.OM3 randomized trial.

    PubMed

    Andreeva, Valentina A; Latarche, Clotilde; Hercberg, Serge; Briançon, Serge; Galan, Pilar; Kesse-Guyot, Emmanuelle

    2014-01-01

    Despite growing attention to nutrition and quality of life in cardiovascular disease survivors, the impact of dietary factors according to disease type or to quality of life domain is poorly understood. We investigated the effects of B vitamin and/or n-3 fatty acid supplementation on health-related quality of life among survivors of stroke, myocardial infarction, or unstable angina. We performed ancillary analyses of the SU.FOL.OM3 trial (2003-2009; France). In total, 2,501 men (mean age = 61 y) and women (mean age = 63 y) were randomized in a 2×2 factorial design to: 1) 0.56 mg 5-methyl-tetrahydrofolate, 3 mg vitamin B6, 0.02 mg vitamin B12; 2) 600 mg eicosapentaenoic and docosahexaenoic acids in a 2∶1 ratio; 3) B vitamins and n-3 fatty acids combined; or 4) placebo. Health-related quality of life was evaluated at follow-up with the Medical Outcomes Study 36-Item Short Form Health Survey. Data from 2,029 individuals were used in this analysis. After 3.1±0.4 y, no effects of supplementation with either B vitamins or n-3 fatty acids on quality of life (physical or mental health domains) were found. However, participants receiving B vitamins had slightly more activity limitations due to emotional problems compared with those not receiving B vitamins (mean difference = 3.8; 95% CI: 0.4, 7.1). A significant interaction of treatment by prior disease revealed an inverse association between n-3 fatty acids and vitality among myocardial infarction survivors (mean difference = 2.9; 95% CI: 0.5, 5.2). There were no beneficial effects of supplementation with relatively low doses of B vitamins or n-3 fatty acids on health-related quality of life in cardiovascular disease survivors. The adverse effects of B vitamins on activity limitations and of n-3 fatty acids on vitality among individuals with prior myocardial infarction merit confirmation.

  3. Glacial-interglacial changes in H218O, HDO and deuterium excess - results from the fully coupled ECHAM5/MPI-OM Earth system model

    NASA Astrophysics Data System (ADS)

    Werner, M.; Haese, B.; Xu, X.; Zhang, X.; Butzin, M.; Lohmann, G.

    2016-02-01

    In this study we present the first results of a new isotope-enabled general circulation model set-up. The model consists of the fully coupled ECHAM5/MPI-OM atmosphere-ocean model, enhanced by the JSBACH interactive land surface scheme and an explicit hydrological discharge scheme to close the global water budget. Stable water isotopes H218O and HDO have been incorporated into all relevant model components. Results of two equilibrium simulations under pre-industrial and Last Glacial Maximum conditions are analysed and compared to observational data and paleoclimate records for evaluating the model's performance in simulating spatial and temporal variations in the isotopic composition of the Earth's water cycle. For the pre-industrial climate, many aspects of the simulation results of meteoric waters are in good to very good agreement with both observations and earlier atmosphere-only simulations. The model is capable of adequately simulating the large spread in the isotopic composition of precipitation between low and high latitudes. A comparison to available ocean data also shows a good model-data agreement; however, a strong bias of overly depleted ocean surface waters is detected for the Arctic region. Simulation results under Last Glacial Maximum boundary conditions also fit to the wealth of available isotope records from polar ice cores, speleothems, as well as marine calcite data. Data-model evaluation of the isotopic composition in precipitation reveals a good match of the model results and indicates that the temporal glacial-interglacial isotope-temperature relation was substantially lower than the present spatial gradient for most mid- to high-latitudinal regions. As compared to older atmosphere-only simulations, a remarkable improvement is achieved for the modelling of the deuterium excess signal in Antarctic ice cores. Our simulation results indicate that cool sub-tropical and mid-latitudinal sea surface temperatures are key for this progress. A recently

  4. 76 FR 58300 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-005-C. FR Notice: 74 FR 23747 (May 20... CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-006-C. FR Notice: 74 FR 23748 (May 20, 2009.... Regulation Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-039-C. FR Notice: 74 FR...

  5. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, workers discuss the next step in moving the orbital maneuvering system (OMS) pod behind them. The OMS pod will be installed on Atlantis. Two OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, workers discuss the next step in moving the orbital maneuvering system (OMS) pod behind them. The OMS pod will be installed on Atlantis. Two OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  6. Dust in 3CR radio galaxies: On the FR 1 - FR 2 difference

    NASA Astrophysics Data System (ADS)

    Müller, S. A. H.; Haas, M.; Siebenmorgen, R.; Klaas, U.; Meisenheimer, K.; Chini, R.; Albrecht, M.

    2004-11-01

    We compare three 3CR samples of 11 FR 1 galaxies, 17 FR 2 galaxies and 18 lobe-dominated quasars contained in the ISO Data Archive. In contrast to the powerful FR 2 galaxies with edge-brightened lobes, the low radio power FR 1 galaxies in our sample do not exhibit any high MIR or FIR dust luminosity, which is typical for a buried, intrinsically more luminous AGN. This consolidates the fact already inferred from optical studies that their AGNs have only a relatively low luminosity. Also the FR 1 galaxies show a high FIR/MIR luminosity ratio, compared to quasars, suggesting that their FIR luminosity is substantially powered by the interstellar radiation field (ISRF) of the giant elliptical hosts. Finally, we discuss the FR 1 - FR 2 morphological dichotomy. FR 1 galaxies do not have more interstellar matter (ISM) than FR 2s as traced - on the large scale - by the cool FIR emitting dust and - in the nuclear region - by the warm MIR emitting dust. Due to the lack of central gas we suggest that the black holes of our FR 1 galaxies are fed at a lower accretion rate than those of the FR 2 galaxies. Based on observations with the Infrared Space Observatory ISO, an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, the Netherlands and the UK) and with the participation of ISAS and NASA.

  7. 78 FR 19098 - Wage Methodology for the Temporary Non-Agricultural Employment H-2B Program; Delay of Effective Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... 1, 2012, and which was previously made effective September 30, 2011, at 76 FR 45667 (August 1, 2011); delayed to November 30, 2011, at 76 FR 59896 (September 28, 2011); to January 1, 2012, at 76 FR 73508 (November 29, 2011); to October 1, 2012, at 76 FR 82115 (December 30, 2011); and to March 27, 2013, at 77 FR...

  8. Quadrupole moment of 203Fr

    NASA Astrophysics Data System (ADS)

    Wilkins, S. G.; Lynch, K. M.; Billowes, J.; Binnersley, C. L.; Bissell, M. L.; Cocolios, T. E.; Goodacre, T. Day; de Groote, R. P.; Farooq-Smith, G. J.; Flanagan, K. T.; Franchoo, S.; Ruiz, R. F. Garcia; Gins, W.; Heylen, H.; Koszorús, Á.; Neyens, G.; Stroke, H. H.; Vernon, A. R.; Wendt, K. D. A.; Yang, X. F.

    2017-09-01

    The spectroscopic electric quadrupole moment of the neutron-deficient francium isotope 203Fr was measured by using high-resolution collinear resonance ionization spectroscopy (CRIS) at the CERN Isotope Separation On-Line Device (ISOLDE) facility. A remeasurement of the 207Fr quadrupole moment was also performed, resulting in a departure from the established literature value. A sudden increase in magnitude of the 203Fr quadrupole moment, with respect to the general trend in the region, points to an onset of static deformation at N =116 in the 87Fr isotopic chain. Calculation of the static and total deformation parameters show that the increase in static deformation only cannot account for the observed departure of its relative charge radius from the 82Pb chain.

  9. 75 FR 79759 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Action 04/16/10 75 FR 2012 Regulatory Flexibility Analysis Required: Yes Agency Contact: Mohammed Khan Phone: 202 586-7892 Email: mohammed.khan@ee.doe.gov RIN: 1904-AA90 BILLING CODE 6450-01-S ...

  10. 78 FR 79333 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    .... Discussion On June 9, 2000, we issued AD 2000-12-12, Amendment 39-11790 (65 FR 39072, June 23, 2000). That AD... superseded AD 95-10-03, Amendment 39-9220 (60 FR 25604, May 12, 1995). Since we issued AD 2000-12-12, Amendment 39-11790 (65 FR 39072, June 23, 2000), The European Aviation Safety Agency (EASA), which is...

  11. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods is being moved for installation on Atlantis. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods is being moved for installation on Atlantis. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  12. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, technicians move an orbital maneuvering system (OMS) pod into the correct position on Atlantis. The OMS pod is one of two that are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, technicians move an orbital maneuvering system (OMS) pod into the correct position on Atlantis. The OMS pod is one of two that are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  13. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, technicians make final adjustments to the orbital maneuvering system (OMS) pod being installed on Atlantis. The OMS pod is one of two that are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, technicians make final adjustments to the orbital maneuvering system (OMS) pod being installed on Atlantis. The OMS pod is one of two that are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  14. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, an orbital maneuvering system (OMS) pod is moved into place on Atlantis. It is one of two OMS pods attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, an orbital maneuvering system (OMS) pod is moved into place on Atlantis. It is one of two OMS pods attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  15. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods is lifted off its stand to move it toward Atlantis for installation. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, one of two orbital maneuvering system (OMS) pods is lifted off its stand to move it toward Atlantis for installation. The OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  16. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, technicians make adjustments to the orbital maneuvering system (OMS) pod being installed on Atlantis. The OMS pod is one of two that are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, technicians make adjustments to the orbital maneuvering system (OMS) pod being installed on Atlantis. The OMS pod is one of two that are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  17. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, an orbital maneuvering system (OMS) pod is moved closer to Atlantis for installation. Two OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, an orbital maneuvering system (OMS) pod is moved closer to Atlantis for installation. Two OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  18. KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, an orbital maneuvering system (OMS) pod is suspended in air as it is moved toward Atlantis for installation. Two OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

    NASA Image and Video Library

    2003-10-30

    KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, an orbital maneuvering system (OMS) pod is suspended in air as it is moved toward Atlantis for installation. Two OMS pods are attached to the upper aft fuselage left and right sides. Fabricated primarily of graphite epoxy composite and aluminum, each pod is 21.8 feet long and 11.37 feet wide at its aft end and 8.41 feet wide at its forward end, with a surface area of approximately 435 square feet. Each pod houses the Reaction Control System propulsion components used for inflight maneuvering and is attached to the aft fuselage with 11 bolts.

  19. 77 FR 34943 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ...-01) The Graduate Fellowship Programs Participants Study, 70 FR 51348-51351 (August 30, 2005). 2. (18... Graduate Fellowship Programs Participants Study, 70 FR 51348- 51351 (August 30, 2005). 18-17-02 Follow...

  20. 75 FR 68169 - Participants' Choices of TSP Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... Thrift Savings Plan regulations, which was published in the Federal Register of June 1, 2005 (70 FR 32208... correction was published in the Federal Register on June 1, 2005 (70 FR 32208). As published, the final...

  1. 75 FR 62111 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ..., 1993; 58 FR 10562). KPAC.01, Classified Container Information Form DA 727 (February 22, 1993; 58 FR 10562). KDCE.03, DA Form 727 Classified Container Information File 503-02 (February 22, 1993; 58...

  2. 78 FR 37565 - Endangered Species; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ..., 2012. 91700A Reptile Wrangler LLC... 77 FR 74506; December January 17, 2013. 14, 2012. 89184A Cinco... 12777; February April 11, 2013. 25, 2013. 034669 Randar's Reptiles...... 78 FR 12777; February April...

  3. 77 FR 47787 - Additional Requirements for Charitable Hospitals; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ...) that was published in the Federal Register on Tuesday, June 26, 2012 (77 FR 38148). The proposed... subject of FR Doc. 2012-15537, is corrected as follows: 1. On page 38153, in the preamble, column 1,...

  4. La contribución de los Centros Colaboradores de la OMS/OPS en los avances de la promoción de la salud en América Latina.

    PubMed

    Arroyo, Hiram V; Mantilla Uribe, Blanca P; Contreras Rengifo, Adolfo; Westphal, Marcia F; Mendes, Rosilda

    2016-09-01

    Los "Centros Colaboradores" de la Organización Mundial de la Salud (OMS) son instituciones designadas para prestar apoyo estratégico en el desarrollo de los objetivos y la ejecución de las actividades de la OMS, y para generar capacidad institucional en países y regiones. En las Américas existen ocho Centros Colaboradores directamente relacionados a la promoción de la salud. Cuatro centros se ubican en Norteamérica y los otros cuatro en América Latina. El propósito de este artículo es describir los Centros Colaboradores de la Región de América Latina. Los centros han sido importantes en el desarrollo de la agenda de promoción de la salud de la región, la consolidación de la estrategia de entornos saludables y el fortalecimiento de las redes académicas y profesionales de promoción de la salud. © The Author(s) 2015.

  5. Space Shuttle AFRSI OMS pod environment test using model 81-0 test fixture in the Ames Research Center 9x7-foot supersonic wind tunnel (OS-314A/B/C)

    NASA Technical Reports Server (NTRS)

    Collette, J. G. R.

    1984-01-01

    A test was conducted in the NASA/Ames Research Center 9x7-foot Supersonic Wind Tunnel to help resolve an anomaly that developed during the STS-6 orbiter flight wherein sections of the Advanced Flexible Reusable Surface Insulation (AFRSI) covering the OMS pods suffered some damage. A one-third scale two-dimensional shell structure model of an OMS pod cross-section was employed to support the test articles. These consisted of 15 AFRSI blanket panels form-fitted over the shell structures for exposure to simulated flight conditions. Of six baseline blankets, two were treated with special surface coatings. Two other panels were configured with AFRSI sections removed from the OV099 orbiter vehicle after the STS-6 flight. Seven additional specimens incorporated alternative designs and repairs. Following a series of surface pressure calibration runs, the specimens were exposed to simulated ascent and entry dynamic pressure profiles. Entry conditions included the use of a vortex generator to evaluate the effect of shed vortices on the AFRSI located in the area of concern.

  6. α-Conotoxin OmIA Is a Potent Ligand for the Acetylcholine-binding Protein as Well as α3β2 and α7 Nicotinic Acetylcholine Receptors*

    PubMed Central

    Talley, Todd T.; Olivera, Baldomero M.; Han, Kyou-Hoon; Christensen, Sean B.; Dowell, Cheryl; Tsigelny, Igor; Ho, Kwok-Yiu; Taylor, Palmer; McIntosh, J. Michael

    2016-01-01

    The molluskan acetylcholine-binding protein (AChBP) is a homolog of the extracellular binding domain of the pentameric ligand-gated ion channel family. AChBP most closely resembles the α-subunit of nicotinic acetylcholine receptors and in particular the homomeric α7 nicotinic receptor. We report the isolation and characterization of an α-conotoxin that has the highest known affinity for the Lymnaea AChBP and also potently blocks the α7 nAChR subtype when expressed in Xenopus oocytes. Remarkably, the peptide also has high affinity for the α3β2 nAChR indicating that α-conotoxin OmIA in combination with the AChBP may serve as a model system for understanding the binding determinants of α3β2 nAChRs. α-Conotoxin OmIA was purified from the venom of Conus omaria. It is a 17-amino-acid, two-disulfide bridge peptide. The ligand is the first α-conotoxin with higher affinity for the closely related receptor subtypes, α3β2 versus α6β2, and selectively blocks these two subtypes when compared with α2β2, α4β2, and α1β1δε nAChRs. PMID:16803900

  7. 78 FR 29624 - Rules on Determining Hearing Appearances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ... 76940) \\2\\ and July 8, 2010 (75 FR 39154).\\3\\ \\1\\ The NPRM is available at: http://www.gpo.gov/fdsys/pkg/FR2007-1029/pdf/E7-20690.pdf . \\2\\ The final rules are available at: http://www.gpo.gov/fdsys/pkg/FR-2008-12-18/pdf/E8-30056.pdf . \\3\\ The final rules are available at: http://www.gpo.gov/fdsys/pkg/FR-2010...

  8. 76 FR 29279 - Calvert Cliffs 3 Nuclear Project, LLC and Unistar Nuclear Operating Services, LLC; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... the Federal Register on April 21, 2010 (76 FR 20867), and by the U.S. Environmental Protection Agency on April 26, 2010 and April 30, 2010 (76 FR 21625 and 76 FR 22778). The purpose of this notice is...

  9. 78 FR 79660 - Enhancing Agricultural Coexistence; Extension of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Page 79660] [FR... on November 4, 2013 (78 FR 65960) is extended. We will consider all comments that we receive on or...: On November 4, 2013, we published in the Federal Register (78 FR 65960-65962, Docket No....

  10. 78 FR 80379 - Federal Acquisition Regulation; Trade Agreements Thresholds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 80379-80381] [FR Doc No: 2013-31151] DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION... (78 FR 76700), the United States Trade Representative published new procurement thresholds. The United... and Remedies (DEC 2013) * * * * * [FR Doc. 2013-31151 Filed 12-30-13; 8:45 am] BILLING CODE 6820-EP-P...

  11. 78 FR 30327 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... William Bean 77 FR 26779; May 7, February 27, 2013. 2012. 71354A Canyon Exotic Game 77 FR 26779; May 7... 26779; May 7, June 21, 2012. 2012. 72653A William Bean 77 FR 26779; May 7, June 21, 2012. 2012. 71823A...

  12. 78 FR 79329 - Airworthiness Directives; Bombardier, Inc. Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... (70 FR 43032, July 26, 2005). That AD required actions intended to address an unsafe condition on the products listed above. Since we issued AD 2005-15-04, Amendment 39-14193 (70 FR 43032, July 26, 2005... that are required by AD 2005-15-04, Amendment 39-14193 (70 FR 43032, July 26, 2005), and retained...

  13. 78 FR 65583 - Capital Planning and Stress Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... stress tests of federally insured credit unions (FICUs) with assets of $10 billion or more. NCUA further... stress tests.\\3\\ \\1\\ 76 FR 74631 (Dec. 1, 2011). \\2\\ Id. \\3\\ See 77 FR 61238 (Oct. 9, 2012); 77 FR 62378... Supervisory Stress Testing NCUA will conduct independent stress tests on all covered credit unions based...

  14. 76 FR 4936 - Granular Polytetrafluoroethylene Resin From Italy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... on granular PTFE resin from Italy and Japan (75 FR 67082-67083 and 67105-67108, November 1, 2010... correction of the initiation notice on January 12, 2011 (76 FR 2083). On January 13, 2011, Commerce notified... 17, 2011; Responses to the 13 items requested in the Commission's notice of institution (75 FR...

  15. Cross Sections: No 6 Hold Section at Fr 178 Looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Cross Sections: No 6 Hold Section at Fr 178 Looking Fwd, No 7 Hold Section at No 154 Looking Fwd, No 7 Hold Section at Fr 195 Looking Fwd Showing Trans 194, No 7 Hold Section at Fr 198 Looking Fwd - General John Pope, Suisun Bay Reserve Fleet, Benicia, Solano County, CA

  16. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959...

  17. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959...

  18. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959...

  19. 76 FR 72968 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    .... Applicant Federal Register notice Permit issuance date 46259A Jefferey Spivery...... 76 FR 54480; September 1, November 2, 2011. 2011. 52683A Carlos Ramirez........ 76 FR 60862; September 30, November 3, 2011. 2011. 50923A Woolsey Caye 76 FR 60862; September 30, November 3, 2011. 2011. 49805A Graham Banes 76...

  20. 78 FR 2304 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Approving a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... (November 19, 2012), 77 FR 70511 (November 26, 2012) (SR-CBOE-2012-109) (``Notice''). II. Description of the... corresponding order to the other trading center. \\4\\ See Notice, 77 FR at 70511. \\5\\ See Notice, 77 FR at 70511..., 77 FR at 70512. For examples of some of the circumstances in which the Exchange may decide to...

  1. 78 FR 69612 - Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee Meetings-Title...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... Federal Register (77 FR 25658) announcing our intent to establish a negotiated rulemaking committee under... in the Federal Register (78 FR 22467), which we corrected on April 30, 2013 (78 FR 25235), announcing... the Federal Register (78 FR 27880) the addition of a fourth hearing. The hearings were held on May...

  2. 78 FR 79619 - Patient Protection and Affordable Care Act; Program Integrity: Exchange, Premium Stabilization...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 79619-79620] [FR Doc No: 2013-31319] DEPARTMENT OF HEALTH AND HUMAN SERVICES 45 CFR Part 155 [CMS.... Background In FR Doc. 2013-25326 of October 30, 2013 (78 FR 65046), final rule entitled ``Patient Protection... Standards; Amendments to the HHS Notice of Benefit and Payment Parameters for 2014 (78 FR 65046), there...

  3. 77 FR 35652 - Approval and Promulgation of Implementation Plans and Designations of Areas for Air Quality...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... attainment. See 60 FR 36723 (July 18, 1995) (Salt Lake and Davis Counties, Utah, 1-hour ozone); 61 FR 20458... 12, 2003) (St Louis, Missouri, 1-hour ozone); 69 FR 21717 (April 22, 2004) (San Francisco Bay Area, 1.... Louis, Missouri-Illinois, 1997 8-hour ozone), 76 FR 7145 (November 15, 2011) (Charlotte, North Carolina...

  4. 75 FR 69653 - Energy Conservation Program for Consumer Products: Decision and Order Granting a Waiver to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ...] [FR Doc No: 2010-28646] DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy [Case No... 22, 2006. 71 FR 48913. DOE received one comment on the Whirlpool petition, from a private citizen who... Samsung's interim waivers on September 16, 2010. (75 FR 57915; 75 FR 57937). Table 5.1 of Appendix...

  5. 77 FR 72851 - California State Nonroad Engine Pollution Control Standards; Portable Equipment Registration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... PERP for portable engines and equipment fall within the scope of previously issued authorizations or...(e)(2)(ii). \\29\\ See 74 FR 32744, 32761 (July 8, 2009); 49 FR 18887, 18889- 18890 (May 3, 1984). \\30\\ CARB, Resolution 07-9 at 5. \\31\\ 49 FR 18887, 18890 (May 3, 1984); see also 76 FR 34693 (June 14,...

  6. 76 FR 13188 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... description of report: These information collections are authorized pursuant to Section 11(d) of the Federal Reserve Act (12 U.S.C. 248(d)) and are voluntary. The ability of the Federal Reserve to maintain the.... Treasury's Bureau of Engraving and Printing and the CTO. The FR 3054a, FR 3054b, FR 3054c, and FR 3054d...

  7. 76 FR 34633 - Medicare Program; Proposed Changes to the Hospital Inpatient Prospective Payment Systems for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    .... SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2011-9644 of May 5, 2011 (76 FR 25788), there were a number...InpatientPPS/01_overview.asp ). III. Correction of Errors In FR Doc. 2011-9644 of May 5, 2011 (76 FR...

  8. 78 FR 39730 - Medicare Program; Notification of Closure of Teaching Hospitals and Opportunity To Apply for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... INFORMATION CONTACT: Miechal Lefkowitz, (212)-616-2517. SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2013-12952 of May 31, 2013 (78 FR 32663), there was a typographical error that is identified and.... Correction of Errors In FR Doc. 2013-12952 of May 31, 2013 (78 FR 32663), make the following corrections:...

  9. A comparison of observed extreme water levels at the German Bight elaborated through an extreme value analysis (EVA) with extremes derived from a regionally coupled ocean-atmospheric climate model (MPI-OM)

    NASA Astrophysics Data System (ADS)

    Möller, Jens; Heinrich, Hartmut

    2017-04-01

    As a consequence of climate change atmospheric and oceanographic extremes and their potential impacts on coastal regions are of growing concern for governmental authorities responsible for the transportation infrastructure. Highest risks for shipping as well as for rail and road traffic originate from combined effects of extremes of storm surges and heavy rainfall which sometimes lead to insufficient dewatering of inland waterways. The German Ministry of Transport and digital Infrastructure therefore has tasked its Network of Experts to investigate the possible evolutions of extreme threats for low lands and especially for Kiel Canal, which is an important shortcut for shipping between the North and Baltic Seas. In this study we present results of a comparison of an Extreme Value Analysis (EVA) carried out on gauge observations and values derived from a coupled Regional Ocean-Atmosphere Climate Model (MPI-OM). High water levels at the coasts of the North and Baltic Seas are one of the most important hazards which increase the risk of flooding of the low-lying land and prevents such areas from an adequate dewatering. In this study changes in the intensity (magnitude of the extremes) and duration of extreme water levels (above a selected threshold) are investigated for several gauge stations with data partly reaching back to 1843. Different methods are used for the extreme value statistics, (1) a stationary general Pareto distribution (GPD) model as well as (2) an instationary statistical model for better reproduction of the impact of climate change. Most gauge stations show an increase of the mean water level of about 1-2 mm/year, with a stronger increase of the highest water levels and a decrease (or lower increase) of the lowest water levels. Also, the duration of possible dewatering time intervals for the Kiel-Canal was analysed. The results for the historical gauge station observations are compared to the statistics of modelled water levels from the coupled

  10. 78 FR 79712 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Page 79712] [FR Doc No: 2013-31243] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment Request Upon..., Secretary. [FR Doc. 2013-31243 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  11. 78 FR 79714 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Page 79714] [FR Doc No: 2013-31240] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment Request Upon.... [FR Doc. 2013-31240 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  12. 78 FR 79712 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Pages 79712-79714] [FR Doc No: 2013-31239] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment..., Secretary. [FR Doc. 2013-31239 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  13. 78 FR 79711 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Pages 79711-79712] [FR Doc No: 2013-31241] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment..._Mailbox@sec.gov . Dated: December 24, 2013. Elizabeth M. Murphy, Secretary. [FR Doc. 2013-31241 Filed...

  14. 78 FR 79714 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Pages 79714-79715] [FR Doc No: 2013-31242] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment.... Elizabeth M. Murphy, Secretary. [FR Doc. 2013-31242 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  15. 78 FR 79714 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Page 79714] [FR Doc No: 2013-31238] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment Request Upon...@sec.gov . Dated: December 24, 2013. Elizabeth M. Murphy, Secretary. [FR Doc. 2013-31238 Filed...

  16. 75 FR 51444 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ..., CT. Contracting Activity: Department of Defense, Defense Contract Management Agency (DCMA), Boston... 10800, 1421 Jefferson Davis Highway, Arlington, Virginia 22202-3259. FOR FURTHER INFORMATION CONTACT... . SUPPLEMENTARY INFORMATION: Additions On 6/4/2010 (75 FR 31768-31769); 6/11/2010 (75 FR 33270-33271); 6/...

  17. 75 FR 43152 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... . SUPPLEMENTARY INFORMATION: Additions On 5/28/2010 (75 FR 29994-29995) and 6/4/2010 (75 FR 31768-31769), the...-01-285-8355--Padded, yellow, 4 x 6'' unruled self stick notes. NSN: 7530-01-385-7560--Padded,...

  18. 77 FR 37043 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... [Federal Register Volume 77, Number 119 (Wednesday, June 20, 2012)] [Notices] [Page 37043] [FR Doc No: 2012-15232] FEDERAL ELECTION COMMISSION Sunshine Act Meeting AGENCY: Federal Election Commission. FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCMENT: 77 FR 36275 (June 18, 2012). DATE AND TIME:...

  19. 77 FR 37043 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... [Federal Register Volume 77, Number 119 (Wednesday, June 20, 2012)] [Notices] [Page 37043] [FR Doc No: 2012-15194] FEDERAL ELECTION COMMISSION Sunshine Act Meeting AGENCY: Federal Election Commission. Federal Register Citation of Previous Announcement: 77 FR 35680 (June 14, 2012). DATE AND TIME:...

  20. 78 FR 52956 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency... Register (78 FR 36220-36222) a proposed flood hazard determination notice that contained an erroneous table... FR 36220. The table provided here represents the proposed flood hazard determinations and communities...

  1. 62 FR 65388 - Occupational Exposure to Tuberculosis

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-12-12

    ... Tuberculosis AGENCY: Occupational Safety and Health Administration (OSHA), Labor ACTION: Proposed rule... tuberculosis (62 FR 54160). An informal public hearing was scheduled for Washington, D.C., and deadlines were... a new standard for occupational exposure to tuberculosis on October 17, 1997 (62 FR 54160)....

  2. 75 FR 68755 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ...] [FR Doc No: 2010-28354] COMMISSION ON CIVIL RIGHTS Sunshine Act Notice AGENCY: United States Commission on Civil Rights. ACTION: Notice of meeting cancellation. SUMMARY: On October 12, 2010 (75 FR 63144-63145), the U.S. Commission on Civil Rights announced a business meeting to be held on Friday,...

  3. 75 FR 62423 - Proposed Collection, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... [Federal Register Volume 75, Number 195 (Friday, October 8, 2010)] [Notices] [Page 62423] [FR Doc No: 2010-25404] DEPARTMENT OF LABOR Bureau of Labor Statistics Proposed Collection, Comment Request... Labor Statistics. [FR Doc. 2010-25404 Filed 10-7-10; 8:45 am] BILLING CODE 4510-24-P ...

  4. 75 FR 49912 - Foreign-Trade Zone 40-Cleveland, OH; Site Renumbering Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... (Board Order 1351, 69 FR 56038, 9/17/04), April 15, 2005 (Board Order 1384, 70 FR 21736, 4/27/05), April 15, 2005 (Board Order 1386, 70 FR 21736, 4/27/05), December 9, 2005 (Board Order 1425, 70 FR 76023-76024, 12/22/05), December 21, 2005 (Board Order 1428, 70 FR 77376, 12/30/05), December 21, 2005 (Board...

  5. 76 FR 26962 - Airworthiness Directives; Airbus Model A300 B2-1C, A300 B2-203, A300 B2K-3C, A300-B4-103, A300 B4...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... Inspect special Repeat at intervals For airplanes-- area-- not to exceed-- All STGR5 LH and RH 3,600 flight cycles (FR54 through FR58). All STGR22 LH and RH 2,700 flight cycles (FR26 through FR40). All STGR22 RH (FR58 3,000 flight cycles through FR65). All STGR31 LH/RH (FR26 3,000 flight cycles through...

  6. 78 FR 2302 - Self-Regulatory Organizations; C2 Options Exchange, Incorporated; Order Approving a Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... Act Release No. 68260 (November 19, 2012), 77 FR 70496 (November 26, 2012) (SR-C2-2012-038) (``Notice... FR at 70496. \\5\\ See Notice, 77 FR at 70496-97 n.5, n.9, and accompanying text. In its proposal, C2..., routing brokers, or another exchange.\\7\\ \\6\\ See Notice, 77 FR at 70497. For examples of some of...

  7. 77 FR 72846 - California State Nonroad Engine Pollution Control Standards; In-Use Portable Diesel Engines 50...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... FR 36969 (July 20, 1994). \\16\\ See 62 FR 67733 (December 30, 1997). The applicable regulations, now... the California standard. \\17\\ See 59 FR 36969 (July 20, 1994). In order to be consistent with section... EPA review of the State decision to be a narrow one.'' \\22\\ \\22\\ See, e.g., 40 FR 21102-103 (May...

  8. 78 FR 44054 - Wage Methodology for the Temporary Non-Agricultural Employment H-2B Program; Proposed Delay of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... effective on January 1, 2012, and the effective date has been extended a number of times, most recently to... (Aug. 1, 2011); to November 30, 2011, 76 FR 59896 (Sept. 28, 2011); to January 1, 2012, 76 FR 73508 (Nov. 29, 2011); to October 1, 2012, 76 FR 82115 (Dec. 30, 2011); to March 27, 2013, 77 FR 60040 (Oct...

  9. 77 FR 41742 - Reorganization and Expansion of Foreign-Trade Zone 202 Under Alternative Site Framework Los...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ..., the Board adopted the alternative site framework (ASF) (74 FR 1170, 01/12/2009; correction 74 FR 3987, 01/22/2009; 75 FR 71069- 71070, 11/22/2010) as an option for the establishment or reorganization of..., notice inviting public comment was given in the Federal Register (77 FR 8804-8805, 02/15/2012) and the...

  10. 78 FR 40043 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... published a final rule to implement Gulf Reef Fish Amendment 37 (78 FR 27084). That final rule, in part... November 10, 2012 (77 FR 28308, May 14, 2012), and extended through May 15, 2013 (77 FR 67303, November 9... opportunity to comment on the proposed rule for Gulf Reef Fish Amendment 37 (78 FR 10122, February 13,...

  11. 76 FR 76375 - Fresh Garlic From the People's Republic of China: Preliminary Results of the 2009-2010...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ...: Silicon Carbide From the People's Republic of China, 59 FR 22585 (May 2, 1994) (Silicon Carbide). However... rates. \\42\\ See Silicon Carbide, 59 FR at 22586-87. The absence of de facto government control over... management.\\43\\ \\43\\ See, e.g., Silicon Carbide, 59 FR at 22587, and Sparklers, 56 FR at 20589; see also...

  12. 77 FR 43048 - Foreign-Trade Zone 8-Toledo, OH; Application for Reorganization and Expansion Under Alternative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Order 92, 38 FR 3015, 1/31/1973); January 11, 1985 (Board Order 277, 50 FR 2702, 1/18/1985); August 19... FR 9613-9614, 2/28/2005); August 23, 2005 (Board Order 1408, 70 FR 51335, 8/30/2005); and, August 5...; Site 5 (167 acres)--Ohio Northern Global Distribution and Business Training Center, 6722 Commodore...

  13. 75 FR 69484 - Self-Regulatory Organizations; BATS Exchange, Inc.; NASDAQ OMX BX, Inc.; Chicago Board Options...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... Release Nos. 62945 (September 20, 2010), 75 FR 58460 (September 24, 2010) (SR-BATS-2010-025); 62954 (September 20, 2010), 75 FR 59305 (September 27, 2010) (SR-BX- 2010-66); 62951 (September 20, 2010), 75 FR 59309 (September 27, 2010) (SR-CBOE-2010-087); 62949 (September 20, 2010), 75 FR 59315 (September...

  14. 78 FR 60937 - Joint Industry Plan; Order Approving the Fifth Amendment to the National Market System Plan to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ...\\ See Securities Exchange Act Release No. 70274 (August 27, 2013), 78 FR 54305 (``Notice''). II... (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025); 62883 (September 10, 2010), 75 FR... (February 20, 2013), 78 FR 13113 (February 26, 2013). B. Fifth Amendment to the Plan The Fifth...

  15. 78 FR 18246 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... these requirements. DATES: 47 CFR 1.80 and 64.1202, published at 77 FR 71131, November 29, 2012, and at 78 FR 10099, February 13, 2013, are effective March 26, 2013. FOR FURTHER INFORMATION CONTACT..., FCC 12- 129, published at 77 FR 71131, November 29, 2012, and at 78 FR 10099, February 13, 2013....

  16. A polynomial f(R) inflation model

    SciTech Connect

    Huang, Qing-Guo

    2014-02-01

    Motivated by the ultraviolet complete theory of quantum gravity, for example the string theory, we investigate a polynomial f(R) inflation model in detail. We calculate the spectral index and tensor-to-scalar ratio in the f(R) inflation model with the form of f(R) = R + (R{sup 2})/6M{sup 2} + (λn)/2n (R{sup n})/(3M{sup 2}){sup n-1}. Compared to Planck 2013, we find that R{sup n} term should be exponentially suppressed, i.e. |λ{sub n}|∼<10{sup −2n+2.6}.

  17. Zeitgesteuerte und selbstorganisierende Fahrzeug-zu-Fahrzeug-Kommunikation auf Basis von Ad-hoc-WLAN

    NASA Astrophysics Data System (ADS)

    Munstermann, Marco; Heitmann, Hans Heinrich

    Da das Basisprotokoll (CSMA/CA) des WLAN-Standards nicht in der Lage ist, der geforderten Aufgabenstellung gerecht zu werden, muss ein zuverlässiges, fehlertolerantes, faires und skalierbares Protokoll entwickelt werden. Zudem sollte es sich durch eine hohe Verfügbarkeit, eine bestimmbare Aktualisierungsrate und definierte Latenzzeiten auszeichnen.

  18. Literarische Kommunikation und literarische Verfahrensweisen im Fremdsprachenunterricht (Literary Communication and Literary Procedures in Foreign Language Teaching)

    ERIC Educational Resources Information Center

    Kloepfer, Rolf; Melenk, Hartmut

    1978-01-01

    Argues that literature should have a place in the language learning process. Since colloquial and literary styles overlap, it is felt that the two styles should not remain separated in actual life. (Text is in German.) (IFS/WGA)

  19. 75 FR 10692 - Maritime Communications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 80 Maritime Communications ACTION: Final rule; correction. SUMMARY: The Federal Communications Commission published in the Federal Register of February 2, 2010 (75 FR 5241), a document in...

  20. 78 FR 1634 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... analysis is required, and the status of regulations previously reported. ADDRESSES: Director, for Internal... ``disability'' in lieu of the term ``handicap,'' changes to definitions, and other sections based on the... Date FR Cite NPRM 02/00/13 Regulatory Flexibility Analysis Required: No. Agency Contact: Robert W...

  1. 78 FR 44329 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... analysis is required, and the status of regulations previously reported. ADDRESSES: Acting Assistant... of the term ``disability'' in lieu of the term ``handicap,'' changes to definitions, and other....nasa.gov/open . Timetable: Action Date FR Cite NPRM 10/00/13 Regulatory Flexibility Analysis Required...

  2. 78 FR 44251 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... proposing a rule to add the common cold indication to certain over-the-counter (OTC) antihistamine active..... 08/25/00 65 FR 51780 Comment Period End 11/24/00 NPRM (Amendment) (Common Cold)...... 11/00/13... Certain Reference Amounts Customarily Consumed. 5 Over-the-Counter (OTC) 0910-AF31 Drug Review--Cough/Cold...

  3. 78 FR 40430 - De Facto

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... at Less Than Fair Value: Silicon ] Carbide from the People's Republic of China, 59 FR 22585 (May 2, 1994) (``Silicon Carbide'').\\5\\ However, if the Department determined that an exporter of NME-produced... control is critical in determining whether an exporter should receive a separate rate. \\8\\ See Silicon...

  4. 77 FR 59339 - Contractor Qualifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... [Federal Register Volume 77, Number 188 (Thursday, September 27, 2012)] [Rules and Regulations] [Page 59339] [FR Doc No: 2012-23905] DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 209 Contractor Qualifications CFR Correction In Title 48 of the Code of Federal...

  5. 78 FR 20244 - Product Valuation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Office of Natural Resources Revenue 30 CFR Part 1206 Product Valuation CFR Correction In FR Doc. 2013... ``Surface Mining Reclamation and Enforcement'' is corrected to read ``Office of Natural Resources...

  6. 77 FR 73475 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    ..., 2012 120061 areas of Christopher Community www.bakeraecom.c Charlotte County, Constance, Development om..., GA 30009. Muscogee City of Columbus-- The Honorable 420 10th Street, http:// November 12, 2012 135158 Muscogee County Teresa Tomlinson, 2nd Floor, www.bakeraecom.c (Consolidated Mayor, City of Columbus, GA om...

  7. 78 FR 22538 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ...-003; ER12-1329-001. Applicants: EC&R O&M, LLC, Munnsville Wind Farm, LLC, Pioneer Trail Wind Farm, LLC, Settlers Trail Wind Farm, LLC, Stony Creek Wind Farm, LLC, Wildcat Wind Farm I, LLC. Description: EC&R O&M... in the Commission's eLibrary system by clicking on the links or querying the docket number. Any...

  8. 76 FR 30326 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... Nonproliferation and International Security, National Nuclear Security Administration, Department of Energy. ACTION... Nuclear Security Administration, Department of Energy. Telephone: 202-586-3806 or e- mail: Sean.Oehlbert... Energy. Anne M. Harrington, Deputy Administrator, Defense Nuclear Nonproliferation. [FR Doc....

  9. Final CSAPR Revisions Rule (77 FR 10324)

    EPA Pesticide Factsheets

    EPA finalizes revisions to the Transport Rule (76 FR 48208). These revisions address discrepancies in unit-specific modeling assumptions that affect the proper calculation of Transport Rule state budgets and assurance levels in several states.

  10. 75 FR 68789 - Sunshine Act Notices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... (Ninth Floor) Status: This meeting will be open to the public. Items To Be Discussed: Correction and... Werth, Secretary and Clerk of the Commission. [FR Doc. 2010-28223 Filed 11-8-10; 8:45 am] BILLING...

  11. 78 FR 44247 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... published previously a final rule establishing energy conservation standards for ice-cream freezers, self... measuring ice maker energy use. Timetable: Action Date FR Cite NPRM 07/00/13 Final Action...

  12. 76 FR 6134 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    .... Robert E. Feldman, Executive Secretary of the Corporation, at 202-898-7043. Dated: January 31, 2011. Federal Deposit Insurance Corporation. Robert E. Feldman, Executive Secretary. [FR Doc. 2011-2445 Filed...

  13. 78 FR 35812 - Revisions to Procedural Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... Counsel, at 202-789-6820. SUPPLEMENTARY INFORMATION: Regulatory history: 77 FR 23176 (April 18, 2012... because these changes were approved by the Citizens Awareness Court for use in Nuclear Regulatory...

  14. 78 FR 70207 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... FR 46 at junction radius level. This frame, that was previously repaired due to a crack finding in... Friday, except Federal holidays. The AD docket contains this AD, the MCAI, the regulatory evaluation,...

  15. 77 FR 22804 - Sunshine Act Meeting; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Sunshine Act Meeting; Correction AGENCY HOLDING THE MEETING: United States International Trade Commission. Federal Register CITATION OF PREVIOUS ANNOUNCEMENT: 77 FR 22344. ORIGINALLY PUBLISHED TIME...

  16. 77 FR 7942 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... Action 10/31/11 76 FR 67037 Regulatory Flexibility Analysis Required: Yes. Agency Contact: Mohammed Khan, Phone: 202 586-7892, Email: mohammed.khan@ee.doe.gov Wes Anderson, Phone: 202 586-7335, Email: wes...

  17. 77 FR 23513 - Sunshine Act Meeting; Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ... ``News & Events'' on the NTSB home page at www.ntsb.gov . Schedule updates including weather-related..., Iowa, April 17, 2011 (DCA-11-FR-002) NEWS MEDIA CONTACT: Telephone: (202) 314-6100. The press and...

  18. 77 FR 39677 - Performance Review Board Membership

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... [Federal Register Volume 77, Number 129 (Thursday, July 5, 2012)] [Notices] [Page 39677] [FR Doc No: 2012-16331] ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD Performance Review Board Membership AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice....

  19. 75 FR 45562 - Enhancing Airline Passenger Protections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... travel for persons with peanut allergies. See 75 FR 32318 (June 8, 2010). Comments on the matters... coordination regarding the proposals. Accordingly, the Department finds that good cause exists to extend...

  20. Loop quantum f(R) theories

    NASA Astrophysics Data System (ADS)

    Zhang, Xiangdong; Ma, Yongge

    2011-09-01

    As modified gravity theories, the four-dimensional metric f(R) theories are cast into connection-dynamical formalism with real su(2) connections as configuration variables. This formalism enables us to extend the nonperturbative loop quantization scheme of general relativity to any metric f(R) theories. The quantum kinematical framework of f(R) gravity is rigorously constructed, where the quantum dynamics can be launched. Both Hamiltonian constraint operator and master constraint operator for f(R) theories are well defined. Our results show that the nonperturbative quantization procedure of loop quantum gravity are valid not only for general relativity but also for a rather general class of four-dimensional metric theories of gravity.

  1. 77 FR 56607 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... conference call is open to the public. The following business will be conducted: Finish reviewing project..., Forest Supervisor. [FR Doc. 2012-22531 Filed 9-12-12; 8:45 am] BILLING CODE 3410-11-P ...

  2. 76 FR 63601 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ...: 624 Ninth Street, NW., Room 540, Washington, DC 20425. Meeting Agenda This meeting is open to the..., 2011. Kimberly A. Tolhurst, Senior Attorney-Advisor. [FR Doc. 2011-26583 Filed 10-11-11; 11:15 am...

  3. 77 FR 62237 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ...: Open. MATTERS TO BE CONSIDERED: The Commission will consider and act upon the following in open session..., Administrative Assistant. [FR Doc. 2012-25234 Filed 10-10-12; 11:15 am] BILLING CODE 6735-01-P ...

  4. 75 FR 82025 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... [Federal Register Volume 75, Number 249 (Wednesday, December 29, 2010)] [Notices] [Page 82025] [FR Doc No: 2010-32962] EQUAL EMPLOYMENT OPPORTUNITY COMMISSION Sunshine Act Notice AGENCY HOLDING THE MEETING: Equal Employment Opportunity Commission. ``Federal Register'' CITATION OF PREVIOUS ANNOUNCEMENT...

  5. 75 FR 68010 - Federal Salary Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... Management, 1900 E Street, NW., Room 5H17, Washington, DC. FOR FURTHER INFORMATION CONTACT: Charles D. Grimes...-performance-policy@opm.gov . For the President's Pay Agent. John Berry, Director. [FR Doc. 2010-27835 Filed 11...

  6. 76 FR 17521 - Assessments, Large Bank Pricing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... 327 RIN 3064-AD66 Assessments, Large Bank Pricing AGENCY: Federal Deposit Insurance Corporation (FDIC... Register of February 25, 2011 (76 FR 10672), regarding Assessments, Large Bank Pricing. This correction...

  7. 78 FR 67201 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... call on hold if doing so will trigger recorded music or other sound. From time to time, the presiding... sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies with the Americans...

  8. 78 FR 38076 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... disrupting the meeting, please refrain from placing the call on hold if doing so will trigger recorded music.... Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies with...

  9. 78 FR 45568 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... Counsel, at (202) 295-1500. Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov...

  10. 78 FR 73210 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... & General Counsel, at (202) 295-1500. Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc...

  11. 78 FR 39781 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... call on hold if doing so will trigger recorded music or other sound. From time to time, the Chair may... may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . Accessibility: LSC complies with the...

  12. 78 FR 30339 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From.... Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies with...

  13. 78 FR 36602 - Sunshine Act Meeting; Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies with the Americans...

  14. 78 FR 28895 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... Counsel, at (202) 295-1500. Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov...

  15. 78 FR 40515 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... & General Counsel, at (202) 295-1500. Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc...

  16. 78 FR 33114 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From.... Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . Accessibility: LSC complies with...

  17. 78 FR 71725 - Household Movers' Disclosure Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Household Movers' Disclosure Requirements AGENCY: Surface Transportation..., Household Movers' Disclosure Requirements. See 78 FR 18421-01 (Mar. 26, 2013). This collection has been...

  18. Wormhole solutions in f(R) gravity satisfying energy conditions

    NASA Astrophysics Data System (ADS)

    Mazharimousavi, S. Habib; Halilsoy, M.

    2016-10-01

    Without reference to exotic sources construction of viable wormholes in Einstein’s general relativity remained ever a myth. With the advent of modified theories, however, specifically the f(R) theory, new hopes arose for the possibility of such objects. From this token, we construct traversable wormholes in f(R) theory supported by a fluid source which respects at least the weak energy conditions. We provide an example (Example 1) of asymptotically flat wormhole in f(R) gravity without ghosts.

  19. 78 FR 20620 - Procurement List; Additions to and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ...: 7510-00-NIB-9843--Self Stick Rectangular Flag, .5'' x 1.7'', Multi Pack (Red/yellow/blue/green) NPA.... DATES: Effective Date: 5/6/2013. ADDRESSES: Committee for Purchase From People Who Are Blind or Severely.../2012 (77 FR 25146-25147), 5/11/ 2012 (77 FR 27737), 5/25/2012 (77 FR 31335-31336), 6/29/2012 (77...

  20. Nuclear Data Sheets for 225Fr

    SciTech Connect

    Baglin, Coral M.

    2005-05-16

    Nuclear structure data pertaining to {sup 225}Fr have been evaluated, and incorporated into the ENSDF data file. This evaluation includes literature available by 16 May 2005 and supersedes the previous publication for {sup 225}Fr (Y.A. Akovali, ''Nuclear Data Sheets 60, 617 (1990)'', literature cutoff date 1 June 1989). Data have been incorporated from the following references: 1987Co19, 1997BuO3 and 2003AuO3.

  1. Ion transport of Fr nuclear reaction products

    SciTech Connect

    Behr, J.A.; Cahn, S.B.; Dutta, S.B.

    1993-04-01

    Experiments planned for fundamental studies of radioactive atoms in magneto-optic traps require efficient deceleration and transport of nuclear reaction products to energies and locations where they can be trapped. The authors have built a low-energy ion transport system for Francium and other alkalis. A thick Au target is held on a W rod at 45{degrees} to the accelerator beam direction. The heavy-ion fusion reaction 115 MeV {sup 18}O + {sup 197}Au produces {sup 211,210,209}Fr recoil products which are stopped in the target. The target is heated to close to the melting point of Au to allow the Fr to diffuse to the surface, where it is ionized due to Au`s high work function, and is directly extracted by an electrode at 90{degrees} to the accelerator beam direction. The Fr is transported by electrostatic optics {approximately}1 m to a catcher viewed by an {alpha} detector: {ge}15% of the Fr produced in the target reaches the catcher. 2{times}10{sup 5} Fr/sec have been produced at the catcher, yielding at equilibrium a sample of 3x10{sup 7}Fr nuclei. This scheme physically decouples the target diffusion from the surface neutralization process, which can occur at a lower temperature more compatible with the neutral-atom trap.

  2. 76 FR 50714 - Federal Acquisition Regulation; Documenting Contractor Performance; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... Federal Acquisition Regulation; Documenting Contractor Performance; Correction AGENCY: Department of... Performance. DATES: The comment period for the proposed rule published June, 28, 2011, at 76 FR 37704,...

  3. 75 FR 49934 - Notice of Request for Public Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... establish two certification programs, a temporary certification program and a permanent certification... (``Establishment of the Temporary Certification Program for Health Information Technology,'' 75 FR 36158...

  4. 75 FR 10254 - Environmental Impact Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    .... 20100050, Draft EIS, BLM, CA, Stirling Energy Systems (SES) Solar 2 Project, Construct and Operate..., 2010. Robert W. Hargrove, Director, NEPA Compliance Division, Office of Federal Activities. [FR...

  5. 76 FR 80344 - Privacy Act of 1974: Systems of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ...] [FR Doc No: 2011-32942] DEPARTMENT OF COMMERCE National Telecommunications and Information...: National Telecommunications and Information Administration, U.S. Department of Commerce. ACTION: Notice. [[Page 80345

  6. 75 FR 27846 - Alabama Disaster Number AL-00029

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... disaster: Primary Counties (Physical Damage and Economic Injury Loans): Walker. Contiguous Counties... 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR Doc. 2010-11745...

  7. 78 FR 52517 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... Counseling Record (July 6, 2011, 76 FR 39389). Changes: * * * * * ] System name: Delete entry and replace with ``Chaplain Counseling Care Files.'' * * * * * Retention and disposal: Delete entry and replace...

  8. Exploring plane-symmetric solutions in f(R) gravity

    SciTech Connect

    Shamir, M. F.

    2016-02-15

    The modified theories of gravity, especially the f(R) gravity, have attracted much attention in the last decade. This paper is devoted to exploring plane-symmetric solutions in the context of metric f(R) gravity. We extend the work on static plane-symmetric vacuum solutions in f(R) gravity already available in the literature [1, 2]. The modified field equations are solved using the assumptions of both constant and nonconstant scalar curvature. Some well-known solutions are recovered with power-law and logarithmic forms of f(R) models.

  9. 75 FR 27845 - Tennessee Disaster Number TN-00038

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ..., Hardin, Jackson, Lauderdale, Lawrence, Lewis, Macon, Robertson, Smith, Stewart, Trousdale, Wayne, Wilson... Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR...

  10. 77 FR 75560 - Chlorantraniliprole; Pesticide Tolerances, Technical Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... insecticide chlorantraniliprole on multiple commodities. This document corrects inadvertent errors and... for residues of the insecticide chlorantraniliprole in or on multiple commodities. (77 FR 60311). That...

  11. Gravitomagnetic gyroscope precession in Palatini f(R) gravity

    SciTech Connect

    Ruggiero, Matteo Luca

    2009-04-15

    We study gravitomagnetic effects in the Palatini formalism of f(R) gravity. On using the Kerr-de Sitter metric, which is a solution of f(R) field equations, we calculate the impact of f(R) gravity on the gravitomagnetic precession of an orbiting gyroscope. We show that, even though an f(R) contribution is present in principle, its magnitude is negligibly small and far to be detectable in the present (like GP-B) and foreseeable space missions or observational tests around the Earth.

  12. Pollen Fertility Restoration by Nuclear Gene Fr in Cms Bean: Nuclear-Directed Alteration of a Mitochondrial Population

    PubMed Central

    He, S.; Lyznik, A.; Mackenzie, S.

    1995-01-01

    Two nuclear genes, Fr and Fr2, have been identified that restore pollen fertility to cytoplasmic male sterile (CMS) common bean (Phaseolus vulgaris L.) by apparently distinct mechanisms. Whereas Fr2 appears to suppress the expression of a male sterility associated mitochondrial sequence (designated pvs), Fr restores pollen fertility by causing the elimination of this unusual mitochondrial DNA segment. To further investigate the mechanism of Fr action, Fr and Fr2 were cointroduced into the nucleus of a bean line containing the sterility inducing cytoplasm. When the effect of pvs was suppressed by Fr2, the presence of Fr no longer directed the elimination of the mitochondrial pvs sequence. This result suggests that the Fr function is dependent on proper expression of the pvs sequence. To evaluate the temporal and spatial patterns of Fr action, we undertook a polymerase chain reaction-based approach to trace the fate of the pvs sequence in different tissues of F(2) and F(3) fertile-restored plants derived from a genetic cross between a cytoplasmic male sterile line of common bean, CMS-Sprite (frfr), and fertility restorer line R351 (FrFr). We demonstrate that the Fr-directed disappearance of pvs sequence occurs during flower development. Elimination of the pvs sequence from developing megaspores results in permanent fertility restoration in the following generations. Genetic analysis demonstrated that permanent fertility restoration, that is, the complete elimination of pvs from reproductive tissues requires two doses of the Fr allele or the absence of fr in F(2) individuals. The effect of Fr was reversible until full fertility was achieved. On the basis of these results, we propose a model for the mechanism of pvs elimination by the Fr gene and discuss the dynamics of pvs-containing mitochondrial transmission in the presence of the Fr gene. PMID:7713444

  13. 76 FR 2712 - Ocwen Loan Servicing, LLC, Including Workers Whose Wages Were Reported Under Barclays Capital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Register on December 8, 2010 (75 FR 76488). The notice as amended on December 17, 2010 to include workers... January 3, 2011 (76 FR 178). At the request of the company, the Department reviewed the certification...

  14. 77 FR 32704 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Order Granting Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ..., 2012), 77 FR 22367 (``Notice''). \\5\\ See letter to Elizabeth M. Murphy, Secretary, Commission, from.... 66625 (March 20, 2012), 77 FR 17548 (March 26, 2012) (SR-MSRB-2012-04). The MSRB noted that,...

  15. 78 FR 79362 - Proposed Flood Elevation Determinations for Nicollet County, Minnesota, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Incorporated Areas. DATES: The proposed rule published October 6, 2011, at 76 FR 62006, is withdrawn as of... INFORMATION: On October 6, 2011, FEMA published a proposed rulemaking at 76 FR 62006, proposing...

  16. 78 FR 79298 - Securities Exempted; Distribution of Shares by Registered Open-End Management Investment Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Business Investment Companies, 23 FR 10484 (Dec. 30, 1958). \\2\\ Amendments to the Offering Exemption Under Regulation E of the Securities Act of 1933, 49 FR 35342 (Sept. 7, 1984). As part of Regulation E, rule...

  17. 78 FR 13007 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Allegheny County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    .../2001 66 FR 52867. PACT--Pennsylvania Allegheny 03/04/1996 NOX 10/12/2001 66 FR 52044. County Thermal... Environmental protection, Air pollution control, Incorporation by reference, Nitrogen dioxide, Ozone,...

  18. 77 FR 60096 - Adding International Energy Efficiency (IEE) Certificate to List of Certificates a Recognized...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... International Anti-Fouling System Certificate. See, respectively, 74 FR 21554, May 8, 2009; and 76 FR 76896, Dec... Security Delegation No. 0170.1 and Aug. 8, 2011 Delegation of Authority, Anti-Fouling Systems. 2. Revise...

  19. 76 FR 62148 - Title VI; Proposed Circular, Environmental Justice; Proposed Circular

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... Federal Transit Administration Title VI; Proposed Circular, Environmental Justice; Proposed Circular...; Proposed Circular'' and ``Environmental Justice; Proposed Circular.'' FOR FURTHER INFORMATION CONTACT: For... Circular'' (76 FR 60593) and ``Environmental Justice; Proposed Circular'' (76 FR 60590). Corrections The...

  20. 76 FR 15224 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... Regulatory Burden; Retrospective Review Under E.O. 13563 AGENCY: Office of the Secretary, Labor. ACTION...: E.O. 13653, 76 FR 3821, Jan. 21, 2011; E.O. 12866, 58 FR 51735, Oct. 4, 1993. Dated: March 15,...

  1. 76 FR 18104 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... Regulatory Burden; Retrospective Review Under E.O. 13563 AGENCY: Office of the Secretary, Labor. ACTION...: E.O. 13653, 76 FR 3821, Jan. 21, 2011; E.O. 12866, 58 FR 51735, Oct. 4, 1993. William E....

  2. 78 FR 33977 - Approval and Promulgation of Air Quality Implementation Plans; Delaware, District of Columbia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ...?collectionCode=CFR . C. Maryland Section 52.1072 Conditional approval. On April 17, 2003, (68 FR 19106), EPA... section is being removed because on April 15, 2004 (69 FR 19937), 40 CFR 52.1072 was stayed...

  3. 76 FR 66995 - David T. Koon, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ...); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, 58 FR 51104, 51105 (1993); Bobby Watts... registration (when required), the Agency has revoked the practitioner's registration. James Stephen...

  4. 77 FR 38289 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ..., without extension, Capital Assessments and Stress Testing information collection (FR Y- 14A/Q/M). The... Stress Testing information collection (FR Y-14A/Q/M). In recognition of the complexities of the...

  5. 78 FR 25254 - Announcing an Open Meeting of the Information Security and Privacy Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR 13024, February...

  6. 78 FR 72063 - Open Meeting of the Information Security and Privacy Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... include the following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR 13024...

  7. 77 FR 69910 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Withdrawal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... Release No. 67481 (July 20, 2012), 77 FR 43879 (July 26, 2012). \\4\\ See Securities Exchange Act Release No. 67794 (September 6, 2012), 77 FR 56247 (September 12, 2012). For the Commission, by the Division of...

  8. 76 FR 27904 - Approval and Promulgation of Air Quality Implementation Plans; Indiana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ..., Lead, Nitrogen dioxide, Ozone, Particulate matter, Reporting and recordkeeping requirements, Sulfur.../1992, 57 FR 8082. 1-2-22 Cutback asphalt 9/26/1980 11/5/1981, 46 FR 54943. 1-2-22.5 ``Department...

  9. 77 FR 50163 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... facilities). Docket Number: M-2011-010-M FR Notice: 76 FR 69766 (11/9/2011). Petitioner: Specialty Granules... Granules, Inc., 1101 Opal Court, Suite 315 Hagerstown, Maryland 21740. Mine: Specialty Granules (Ione) LLC...

  10. 76 FR 16595 - Endangered and Threatened Species; Extension of Public Comment Period on Proposed Range Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... of comments on the proposed rule published on February 4, 2011, (76 FR 6383), is extended from April... Spring, MD, (301) 713-1401. SUPPLEMENTARY INFORMATION: Background On February 4, 2011 (76 FR 6383), we...

  11. 78 FR 16817 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; 2013 Commercial Accountability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... implemented the final rule (65 FR 16336, March 28, 2000) that divided the Florida west coast subzone of the... southern Florida west coast subzone (78 FR 15642, March 12, 2013). Under 50 CFR 622.43(a), NMFS is...

  12. 77 FR 30559 - Entergy Nuclear Operations, Inc.; Establishment of Atomic Safety and Licensing Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... delegation by the Commission dated December 29, 1972, published in the Federal Register, 37 FR 28,710 (1972... accordance with the NRC E-filing rule, which the NRC promulgated in August 2007 (72 FR 49,139). Issued...

  13. 75 FR 5040 - Extension of Period for Comments on Enhancement in the Quality of Patents

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... of Patents, 74 FR 65093 (Dec. 9, 2009), 1350 Off. Gaz. Pat. Office 46 (Jan. 5, 2010). The USPTO..., 2010. See Request for Comments on Enhancement in the Quality of Patents, 74 FR at 65094, 1350 Off. Gaz...

  14. 76 FR 21381 - Determination of Regulatory Review Period for Purposes of Patent Extension; ATRYN; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... Register of March 21, 2011 (76 FR 15323). The document announced the determination of the regulatory review...-796-9138. SUPPLEMENTARY INFORMATION: In FR Doc. 2011-6509, appearing on page 15323, in the Federal...

  15. 76 FR 40374 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... Control Number 0910-0646)--Extension In the Federal Register of July 28, 2009 (74 FR 37163), FDA published... April 13, 2011 (76 FR 20677), FDA published a 60-day notice requesting public comment on the proposed...

  16. 77 FR 64827 - Certain Lighting Control Devices Including Dimmer Switches and Parts Thereof (IV); Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... filed by Lutron Electronics Co., Inc. (``Lutron'') of Coopersburg, Pennsylvania. 76 FR 35015-16. The... bonding from the parties and interested non-parties. 77 FR 43612-14 (July 25, 2012). On August 2 and...

  17. 77 FR 69499 - Certain LED Photographic Lighting Devices and Components Thereof; Notice of the Commission's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... Litepanels, Ltd. (collectively, ``Litepanels''). 76 FR 55416 (Sept. 7, 2011). The complaint alleged... disapprove the Commission's action. See Presidential Memorandum of July 21, 2005, 70 FR 43251 (July 26,...

  18. 76 FR 25565 - Defense Federal Acquisition Regulations Supplement; Guidance on Personal Services (DFARS Case...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... their own procedures. DoD published an interim rule at 75 FR 54524 on September 8, 2010, to implement... published at 75 FR 54524 on September 8, 2010, with the following changes: 0 1. The authority citation...

  19. 77 FR 55186 - Executive-Led Indonesia Vietnam Infrastructure Business Development Mission Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ...-Led Indonesia Vietnam Infrastructure Business Development Mission Statement, 77 FR, No. 131, July 9... Statement, 77 FR, No. 131, July 9, 2012, is amended to read as follows: Timeframe for Recruitment...

  20. 76 FR 43347 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... pursuant to Section 6(b) of the Act on February 26, 2009 (74 FR 8813). The last notification was filed with...) of the Act on June 4, 2010 (75 FR 31816). Patricia A. Brink, Director of Civil Enforcement, Antitrust...