Science.gov

Sample records for fr13my10n additional designations

  1. 77 FR 48609 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... Narcotics Kingpin Designation Act (``Kingpin Act''). DATES: The designation by the Director of OFAC of the... of significant foreign narcotics traffickers and their organizations on a worldwide basis....

  2. 78 FR 59766 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... Narcotics Kingpin Designation Act (``Kingpin Act''). DATES: The designation by the Director of OFAC of the... establishes a program targeting the activities of significant foreign narcotics ] traffickers and...

  3. 77 FR 22846 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property has been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  4. 75 FR 65554 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... interests in property has been blocked pursuant to the Foreign Narcotics Kingpin Designation Act (``Kingpin..., 1999. The Kingpin Act establishes a program targeting the activities of significant foreign...

  5. 77 FR 36041 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  6. 78 FR 29814 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property has been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  7. 78 FR 3083 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  8. 78 FR 53007 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  9. 77 FR 56271 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  10. 76 FR 56875 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation Act (``Kingpin... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  11. 76 FR 25407 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property are blocked pursuant to the Foreign Narcotics Kingpin Designation Act... targeting the activities of significant foreign narcotics ] traffickers and their organizations on...

  12. 76 FR 5857 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... the activities of significant foreign narcotics traffickers and their organizations on a...

  13. 77 FR 28670 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  14. 77 FR 63418 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  15. 78 FR 28289 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... of significant foreign narcotics traffickers and their organizations on a worldwide basis....

  16. 77 FR 2347 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... of significant foreign narcotics traffickers and their organizations on a worldwide basis....

  17. 76 FR 5858 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... the activities of significant foreign narcotics traffickers and their organizations on a...

  18. 78 FR 13760 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  19. 78 FR 9997 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... Narcotics Kingpin Designation Act (``Kingpin Act'') (21 U.S.C. 1901-1908, 8 U.S.C. 1182). In addition, OFAC... establishes a program targeting the activities of significant foreign narcotics traffickers and...

  20. Transient design of landfill liquid addition systems.

    PubMed

    Jain, Pradeep; Townsend, Timothy G; Tolaymat, Thabet M

    2014-09-01

    This study presents the development of design charts that can be used to estimate lateral and vertical spacing of liquids addition devices (e.g., vertical well, horizontal trenches) and the operating duration needed for transient operating conditions (conditions until steady-state operating conditions are achieved). These design charts should be used in conjunction with steady-state design charts published earlier by Jain et al. (2010a, 2010b). The data suggest that the liquids addition system operating time can be significantly reduced by utilizing moderately closer spacing between liquids addition devices than the spacing needed for steady-state conditions. These design charts can be used by designers to readily estimate achievable flow rate and lateral and vertical extents of the zone of impact from liquid addition devices, and analyze the sensitivity of various input variables (e.g., hydraulic conductivity, anisotropy, well radius, screen length) to the design. The applicability of the design charts, which are developed based on simulations of a continuously operated system, was also evaluated for the design of a system that would be operated intermittently (e.g., systems only operated during facility operating hours). The design charts somewhat underestimates the flow rate achieved and overestimates the lateral extent of the zone of impact over an operating duration for an intermittently operated system. The associated estimation errors would be smaller than the margin of errors associated with measurement of other key design inputs such as waste properties (e.g., hydraulic conductivity) and wider variation of these properties at a given site due to heterogeneous nature of waste.

  1. 78 FR 66105 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  2. 78 FR 8701 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entity whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  3. 77 FR 58912 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entity whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  4. 77 FR 838 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-06

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities) whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  5. 77 FR 69706 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  6. 75 FR 64781 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... interests in property have been blocked pending investigation pursuant to the Foreign Narcotics Kingpin... the activities of significant foreign narcotics traffickers and their organizations on a...

  7. 77 FR 14592 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... whose property and interests in property have ] been blocked pursuant to the Foreign Narcotics Kingpin... the activities of significant foreign narcotics traffickers and their organizations on a...

  8. 77 FR 4400 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... establishes a program targeting the activities of significant foreign narcotics traffickers and...

  9. 76 FR 25405 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... whose property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin... the activities of significant foreign narcotics traffickers and their organizations on a...

  10. 77 FR 38140 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities) whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  11. 78 FR 62946 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entity whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  12. 77 FR 69707 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property has been blocked pursuant to the Foreign Narcotics Kingpin...

  13. 76 FR 10668 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entities whose property and interests in property have been blocked pursuant to the Foreign Narcotics... program targeting the activities of significant foreign narcotics traffickers and their organizations on...

  14. 75 FR 24773 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation Act... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  15. 75 FR 44311 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation Act (``Kingpin... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  16. 76 FR 58562 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation Act... narcotics traffickers and their organizations on a worldwide basis with the objective of denying...

  17. 76 FR 23644 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation Act... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  18. 75 FR 20425 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  19. 77 FR 6191 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... Narcotics Kingpin Designation Act (``Kingpin Act'') (21 U.S.C. 1901-1908, 8 U.S.C. 1182). DATES: The... establishes a program targeting the activities of significant foreign narcotics traffickers and...

  20. 77 FR 14859 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... interests in property have been blocked pursuant to the Foreign Narcotics Kingpin Designation Act (``Kingpin... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  1. 77 FR 39573 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... Narcotics Kingpin Designation Act (``Kingpin Act'') (21 U.S.C. 1901-1908, 8 U.S.C. 1182). OFAC is also.... The Kingpin Act establishes a program targeting the activities of significant foreign...

  2. 78 FR 53007 - Additional Designation, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... Office of Foreign Assets Control Additional Designation, Foreign Narcotics Kingpin Designation Act AGENCY... property and interests in property has been blocked pursuant to the Foreign Narcotics Kingpin Designation... significant foreign narcotics traffickers and their organizations on a worldwide basis. It provides...

  3. 77 FR 74915 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... entity whose property and interests in property have been blocked pursuant to the Foreign Narcotics... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  4. 76 FR 25406 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin Designation Act... whose property and interests in property have been blocked pursuant to the Foreign Narcotics Kingpin... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  5. 76 FR 58562 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... THE TREASURY Office of Foreign Assets Control Additional Designations, Foreign Narcotics Kingpin... individuals whose property and interests in property have been blocked pursuant to the Foreign Narcotics... activities of significant foreign narcotics traffickers and their organizations on a worldwide basis with...

  6. 78 FR 70630 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... Designations, Foreign Narcotics Kingpin Designation Act AGENCY: Office of Foreign Assets Control, Treasury... been blocked pursuant to the Foreign Narcotics Kingpin Designation Act (``Kingpin Act'') (21 U.S.C... narcotics traffickers and their organizations on a worldwide basis. It provides a statutory framework...

  7. 77 FR 29755 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ..., Foreign Narcotics Kingpin Designation Act AGENCY: Office of Foreign Assets Control, Treasury. ACTION... to the Foreign Narcotics Kingpin Designation Act (``Kingpin Act'') (21 U.S.C. 1901-1908, 8 U.S.C.... The Kingpin Act establishes a program targeting the activities of significant foreign...

  8. 75 FR 36474 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... designated pursuant to the Kingpin Act: 1. MELO PERILLA, Jose Cayetano, c/o CARILLANCA COLOMBIA Y CIA S EN CS..., Jose Cayetano, c/o CARILLANCA COLOMBIA Y CIA S EN CS, Bogota, Colombia; c/o CARILLANCA S.A., San...

  9. Additive Manufacturing of Metal Cellular Structures: Design and Fabrication

    NASA Astrophysics Data System (ADS)

    Yang, Li; Harrysson, Ola; Cormier, Denis; West, Harvey; Gong, Haijun; Stucker, Brent

    2015-03-01

    With the rapid development of additive manufacturing (AM), high-quality fabrication of lightweight design-efficient structures no longer poses an insurmountable challenge. On the other hand, much of the current research and development with AM technologies still focuses on material and process development. With the design for additive manufacturing in mind, this article explores the design issue for lightweight cellular structures that could be efficiently realized via AM processes. A unit-cell-based modeling approach that combines experimentation and limited-scale simulation was demonstrated, and it was suggested that this approach could potentially lead to computationally efficient design optimizations with the lightweight structures in future applications.

  10. Design and fabrication of the progressive addition lenses

    NASA Astrophysics Data System (ADS)

    Qin, Linling; Qian, Lin; Yu, Jingchi

    2011-11-01

    The use of progressive addition lenses (PALs) for the correction of presbyopia has increased dramatically in recent years. These lenses are now being used as the preferred alternative to bifocal and trifocal lenses in many parts of the world. Progressive addition lenses are a kind of opthalmic lenses with freeform surface. The surface curvature of the Progressive addition lenses varies gradually from a minimum value in the upper area, to a maximum value in the lower area. Thus a PAL has a surface with three zones which have very small astigmatism: far-view zone, near-view zone, and intermediate zone. The far view zone and near view zone have relatively constant powers and connected by the intermediate zone with power varies progressively. The design and fabrication technologies of progressive addition lenses have fast progresses because of the massive development of the optical simulation software, multi-axis ultraprecision machining technologies and CNC machining technologies. The design principles of progressive addition lenses are discussed in a historic review. Several kinds of design methods are illustrated, and their advantages and disadvantages are also represented. In the current study, it is shown that the optical characteristics of the different progressive addition lenses designs are significantly different from one another. The different fabrication technologies of Progressive addition lenses are also discussed in the paper. Plastic injection molding and precision-machine turning are the common fabrication technologies for exterior PALs and Interior PALs respectively.

  11. Hyperbolic tangential function-based progressive addition lens design.

    PubMed

    Qiu, Gufeng; Cui, Xudong

    2015-12-10

    The diopter distribution is key to the successful design of a progressive addition lens. A hyperbolic tangential function is then introduced to describe well the desired diopter distribution on the lens. Simulation and fabrication show that the astigmia on the whole surface is very close to the addition, exhibiting superior performance than that of currently used high-order polynomials and cosine functions. Our investigations found that once the diopter distribution design is reasonable, both the direct and indirect methods of constructing a progressive addition lens can give consistent results. With this function we are able to effectively control the design of critical areas, the position, sizes of far-view and near-view zones, as well as the channel of the lens. This study would provide an efficient way to customize different progressive lenses not only for presbyopia, but also for anti-fatigue, office progressive usages, etc.

  12. Applying Additive Manufacturing to a New Liquid Oxygen Turbopump Design

    NASA Technical Reports Server (NTRS)

    O’Neal, T. Derek

    2016-01-01

    A liquid oxygen turbopump has been designed at Marshall Space Flight Center as part of the in-house, Advanced Manufacturing Demonstrator Engine (AMDE) project. Additive manufacturing, specifically direct metal laser sintering (DMLS) of Inconel 718, is used for 77% of the parts by mass. These parts include the impeller, turbine components, and housings. This paper discusses the impacts of the DMLS fabrication technique on the design of the turbopump and lessons learned during DMLS hardware fabrication and material testing.

  13. Additive Manufacturing Design Considerations for Liquid Engine Components

    NASA Technical Reports Server (NTRS)

    Whitten, Dave; Hissam, Andy; Baker, Kevin; Rice, Darron

    2014-01-01

    The Marshall Space Flight Center's Propulsion Systems Department has gained significant experience in the last year designing, building, and testing liquid engine components using additive manufacturing. The department has developed valve, duct, turbo-machinery, and combustion device components using this technology. Many valuable lessons were learned during this process. These lessons will be the focus of this presentation. We will present criteria for selecting part candidates for additive manufacturing. Some part characteristics are 'tailor made' for this process. Selecting the right parts for the process is the first step to maximizing productivity gains. We will also present specific lessons we learned about feature geometry that can and cannot be produced using additive manufacturing machines. Most liquid engine components were made using a two-step process. The base part was made using additive manufacturing and then traditional machining processes were used to produce the final part. The presentation will describe design accommodations needed to make the base part and lessons we learned about which features could be built directly and which require the final machine process. Tolerance capabilities, surface finish, and material thickness allowances will also be covered. Additive Manufacturing can produce internal passages that cannot be made using traditional approaches. It can also eliminate a significant amount of manpower by reducing part count and leveraging model-based design and analysis techniques. Information will be shared about performance enhancements and design efficiencies we experienced for certain categories of engine parts.

  14. A Modular Aerospike Engine Design Using Additive Manufacturing

    NASA Technical Reports Server (NTRS)

    Peugeot, John; Garcia, Chance; Burkhardt, Wendel

    2014-01-01

    A modular aerospike engine concept has been developed with the objective of demonstrating the viability of the aerospike design using additive manufacturing techniques. The aerospike system is a self-compensating design that allows for optimal performance over the entire flight regime and allows for the lowest possible mass vehicle designs. At low altitudes, improvements in Isp can be traded against chamber pressure, staging, and payload. In upper stage applications, expansion ratio and engine envelope can be traded against nozzle efficiency. These features provide flexibility to the System Designer optimizing a complete vehicle stage. The aerospike concept is a good example of a component that has demonstrated improved performance capability, but traditionally has manufacturing requirements that are too expensive and complex to use in a production vehicle. In recent years, additive manufacturing has emerged as a potential method for improving the speed and cost of building geometrically complex components in rocket engines. It offers a reduction in tooling overhead and significant improvements in the integration of the designer and manufacturing method. In addition, the modularity of the engine design provides the ability to perform full scale testing on the combustion devices outside of the full engine configuration. The proposed design uses a hydrocarbon based gas-generator cycle, with plans to take advantage of existing powerhead hardware while focusing DDT&E resources on manufacturing and sub-system testing of the combustion devices. The major risks for the modular aerospike concept lie in the performance of the propellant feed system, the structural integrity of the additive manufactured components, and the aerodynamic efficiency of the exhaust flow.

  15. Applying Additive Manufacturing to a New Liquid Oxygen Turbopump Design

    NASA Technical Reports Server (NTRS)

    O'Neal, Derek

    2016-01-01

    A liquid oxygen turbopump has been designed at Marshall Space Flight Center as part of the in-house, Advanced Manufacturing Demonstrator Engine (AMDE) project. Additive manufacturing, specifically direct metal laser sintering (DMLS) of Inconel 718, is used for 77% of the parts by mass. These parts include the impeller, turbine components, and housings. The near-net shape DMLS parts have been delivered and final machining is underway. Fabrication of the traditionally manufactured hardware is also proceeding. Testing in liquid oxygen is planned for Q2 of FY2017. This topic explores the design of the turbopump along with fabrication and material testing of the DMLS hardware.

  16. Progressive addition lens design by optimizing NURBS surface

    NASA Astrophysics Data System (ADS)

    Liu, Yen-Liang; Hsu, Wei-Yao; Cheng, Yuan-Chieh; Su, Guo-Dung

    2011-10-01

    Progressive addition lenses (PAL) are used to compensate presbyopia, which is induced by losing accommodation of elder eyes. These eyes need different optical power provided by eye glasses while watching objects at different distance. A smaller optical power is required in further distance and a larger one in nearer zone. A progressive addition lens can provides different power requirements in one piece of lens. This paper introduces a whole process of PAL production, from design, fabrication, to measurement. The PAL is designed by optimizing NURBS surface. Parameters of merit function are adjusted to design lenses with different specifications. The simulation results confirm that the power distributes as expected and cylinders are controlled under an acceptable level. Besides, sample lenses have been fabricated and measured. We apply precise-machining to produce the molds for plastic injection. Then, the samples are produced by injecting polycorbonate to the molds. Finally, Ultra Accuracy 3D Profilemeter is used to measure the sample PALs. Practical examinations shows that our designs are achievable and feasible in practice use.

  17. Additives

    NASA Technical Reports Server (NTRS)

    Smalheer, C. V.

    1973-01-01

    The chemistry of lubricant additives is discussed to show what the additives are chemically and what functions they perform in the lubrication of various kinds of equipment. Current theories regarding the mode of action of lubricant additives are presented. The additive groups discussed include the following: (1) detergents and dispersants, (2) corrosion inhibitors, (3) antioxidants, (4) viscosity index improvers, (5) pour point depressants, and (6) antifouling agents.

  18. Design and calibration of zero-additional-phase SPIDER

    SciTech Connect

    Baum, Peter; Riedle, Eberhard

    2005-09-01

    Zero-additional-phase spectral phase interferometry for direct electric field reconstruction (ZAP-SPIDER) is a novel technique for measuring the temporal shape and phase of ultrashort optical pulses directly at the interaction point of a spectroscopic experiment. The scheme is suitable for an extremely wide wavelength region from the ultraviolet to the near infrared. We present a comprehensive description of the experimental setup and design guidelines to effectively apply the technique to various wavelengths and pulse durations. The calibration of the setup and procedures to check the consistency of the measurement are discussed in detail. We show experimental data for various center wavelengths and pulse durations down to 7 fs to verify the applicability to a wide range of pulse parameters.

  19. 49 CFR 173.412 - Additional design requirements for Type A packages.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Additional design requirements for Type A packages. In addition to meeting the general design requirements... gas by chemical reaction and radiolysis. (f) The containment system will retain its...

  20. 49 CFR 173.412 - Additional design requirements for Type A packages.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Additional design requirements for Type A packages. In addition to meeting the general design requirements... gas by chemical reaction and radiolysis. (f) The containment system will retain its...

  1. 49 CFR 173.412 - Additional design requirements for Type A packages.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Additional design requirements for Type A packages. In addition to meeting the general design requirements... gas by chemical reaction and radiolysis. (f) The containment system will retain its...

  2. 49 CFR 173.412 - Additional design requirements for Type A packages.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Additional design requirements for Type A packages. In addition to meeting the general design requirements... gas by chemical reaction and radiolysis. (f) The containment system will retain its...

  3. Optimized and Automated design of Plasma Diagnostics for Additive Manufacture

    NASA Astrophysics Data System (ADS)

    Stuber, James; Quinley, Morgan; Melnik, Paul; Sieck, Paul; Smith, Trevor; Chun, Katherine; Woodruff, Simon

    2016-10-01

    Despite having mature designs, diagnostics are usually custom designed for each experiment. Most of the design can be now be automated to reduce costs (engineering labor, and capital cost). We present results from scripted physics modeling and parametric engineering design for common optical and mechanical components found in many plasma diagnostics and outline the process for automated design optimization that employs scripts to communicate data from online forms through proprietary and open-source CAD and FE codes to provide a design that can be sent directly to a printer. As a demonstration of design automation, an optical beam dump, baffle and optical components are designed via an automated process and printed. Supported by DOE SBIR Grant DE-SC0011858.

  4. Using Generalized Additive Models to Analyze Single-Case Designs

    ERIC Educational Resources Information Center

    Shadish, William; Sullivan, Kristynn

    2013-01-01

    Many analyses for single-case designs (SCDs)--including nearly all the effect size indicators-- currently assume no trend in the data. Regression and multilevel models allow for trend, but usually test only linear trend and have no principled way of knowing if higher order trends should be represented in the model. This paper shows how Generalized…

  5. 2015 Summer Design Challenge: Team A&E (2241) Additively Manufactured Discriminator.

    SciTech Connect

    Miller, Sarah E.; Moore, Brandon James

    2016-11-01

    Current discriminator designs are based on historical designs and traditional manufacturing methods. The goal of this project was to form non-traditional groups to create novel discriminator designs by taking advantage of additive manufacturing. These designs would expand current discriminator designs and provide insight on the applicability of additive manufacturing for future projects. Our design stretched the current abilities of additive manufacturing and noted desired improvements for the future. Through collaboration with NSC, we noted several additional technologies which work well with additive manufacturing such as topology optimization and CT scanning and determined how these technologies could be improved to better combine with additive manufacturing.

  6. 49 CFR 173.466 - Additional tests for Type A packagings designed for liquids and gases.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Additional tests for Type A packagings designed...) Materials § 173.466 Additional tests for Type A packagings designed for liquids and gases. (a) In addition to the tests prescribed in § 173.465, Type A packagings designed for liquids and gases must...

  7. 77 FR 9251 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... designate a class of employees from the Linde Ceramics Plant in Tonawanda, New York, as an addition to the... addition to the SEC: All Atomic Weapons Employees who worked in any area at the Linde Ceramics Plant...

  8. 13 CFR 108.1940 - Procedures for designation of additional Low-Income Geographic Areas

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) as LI Areas. (b) Criteria. SBA will consider one or more of the following factors in determining whether to designate a particular census tract (or equivalent county division) as an additional LI Area... designation of an additional LI Area, SBA will publish in the Federal Register a notice that it is...

  9. Expanding the Design Space: Forging the Transition from 3D Printing to Additive Manufacturing

    NASA Astrophysics Data System (ADS)

    Amend, Matthew

    The synergy of Additive Manufacturing and Computational Geometry has the potential to radically expand the "design space" of solutions available to designers. Additive Manufacturing (AM) is capable of fabricating objects that are highly complex both in geometry and material properties. However, the introduction of any new technology can have a disruptive effect on established design practices and organizations. Before "Design for Additive Manufacturing" (DFAM) is a commonplace means of producing objects employed in "real world" products, appropriate design knowledge must be sufficiently integrated within industry. First, materials suited to additive manufacturing methods must be developed to satisfy existing industry standards and specifications, or new standards must be developed. Second, a new class of design representation (CAD) tools will need to be developed. Third, designers and design organizations will need to develop strategies for employing such tools. This thesis describes three DFAM exercises intended to demonstrate the potential for innovative design when using advanced additive materials, tools, and printers. These design exercises included 1) a light-weight composite layup mold developed with topology optimization, 2) a low-pressure fluid duct enhanced with an external lattice structure, and 3) an airline seat tray designed using a non-uniform lattice structure optimized with topology optimization.

  10. 78 FR 77686 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... designate a class of employees from the Rocky Flats Plant in Golden, Colorado, as an addition to the Special... subcontractors who worked at the Rocky Flats Plant in Golden, Colorado, from April 1, 1952, through December...

  11. 77 FR 9250 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... designate a class of employees from the Savannah River Site in Aiken, South Carolina, as an addition to the... contractors and subcontractors who worked at the Savannah River Site from January 1, 1953, through...

  12. 77 FR 32640 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... designate a class of employees from Sandia National Laboratories in Albuquerque, New Mexico, as an addition... their contractors and subcontractors who worked in any area at Sandia National Laboratories...

  13. 77 FR 32640 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... designate a class of employees from the Clinton Engineer Works in Oak Ridge, Tennessee, as an addition to... Carbon Chemicals Corporation (1947-1949) who were employed at the Clinton Engineer Works in Oak...

  14. Design optimization of heat transfer and fluidic devices by using additive manufacturing

    NASA Astrophysics Data System (ADS)

    Kumar, Nikhil

    After the development of additive manufacturing technology in the 1980s, it has found use in many applications like aerospace, automotive, marine, machinery, consumer and electronic applications. In recent time, few researchers have worked on the applications of additive manufacturing for heat transfer and fluidic devices. As the world has seen a drastic increase in population in last decades which have put stress on already scarce energy resources, optimization of energy devices which include energy storing devices, heat transfer devices, energy capturing devices etc. is need for the hour. Design of energy devices is often constrained by manufacturing constraints thus current design of energy devices is not an optimized one. In this research we want to conceptualize, design and manufacture optimized heat transfer and fluidic devices by exploiting the advantages provided by additive manufacturing. We want to benefit from the fact that very intricate geometry and desired surface finish can be obtained by using additive manufacturing. Additionally, we want to compare the efficacy of our designed device with conventional devices. Work on usage of Additive manufacturing for increasing efficiency of heat transfer devices can be found in the literature. We want to extend this approach to other heat transfer devices especially tubes with internal flow. By optimizing the design of energy systems we hope to solve current energy shortage and help conserve energy for future generation. We will also extend the application of additive manufacturing technology to fabricate "device for uniform flow distribution".

  15. Strengthening the Regression Discontinuity Design Using Additional Design Elements: A Within-Study Comparison

    ERIC Educational Resources Information Center

    Wing, Coady; Cook, Thomas D.

    2013-01-01

    The sharp regression discontinuity design (RDD) has three key weaknesses compared to the randomized clinical trial (RCT). It has lower statistical power, it is more dependent on statistical modeling assumptions, and its treatment effect estimates are limited to the narrow subpopulation of cases immediately around the cutoff, which is rarely of…

  16. STEADY-STATE DESIGN OF VERTICAL WELLS FOR LIQUIDS ADDITION AT BIOREACTOR LANDFILLS

    EPA Science Inventory

    This paper presents design charts that a landfill engineer can use for the design of a vertical well system for liquids addition at bioreactor landfills. The flow rate and lateral and vertical zones of impact of a vertical well were estimated as a function of input variables su...

  17. 75 FR 22409 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... the Santa Susana Field Laboratory as an addition to the Special Exposure Cohort (SEC) under the Energy... HUMAN SERVICES Designation of a Class of Employees for Addition to the Special Exposure Cohort AGENCY: National Institute for Occupational Safety and Health (NIOSH), Department of Health and Human Services...

  18. 78 FR 77685 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... designate a class of employees from the Sandia National Laboratories-Livermore in Livermore, California, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness... employees as an addition to the SEC: ] All employees of the Department of Energy, its predecessor...

  19. Assessment of additive/nonadditive effects in structure-activity relationships: implications for iterative drug design.

    PubMed

    Patel, Yogendra; Gillet, Valerie J; Howe, Trevor; Pastor, Joaquin; Oyarzabal, Julen; Willett, Peter

    2008-12-11

    Free-Wilson (FW) analysis is common practice in medicinal chemistry and is based on the assumption that the contributions to activity made by substituents at different substitution positions are additive. We analyze eight near complete combinatorial libraries assayed on several different biological response(s) (GPCR, ion channel, kinase and P450 targets) and show that only half-exhibit clear additive behavior, which leads us to question the concept of additivity that is widely taken for granted in drug discovery. Next, we report a series of retrospective experiments in which subsets are extracted from the libraries for FW analysis to determine the minimum attributes (size, distribution of substituents, and activity range) necessary to reach the same conclusion about additive/nonadditive effects. These attributes can provide guidelines on when it is appropriate to apply FW analysis as well as for library design, and they also have important implications for further steps in iterative drug design.

  20. Rationally designed multifunctional supramolecular iminium catalysis: direct vinylogous Michael addition of unmodified linear dienol substrates.

    PubMed

    Gu, Yun; Wang, Yao; Yu, Tian-Yang; Liang, Yong-Min; Xu, Peng-Fei

    2014-12-15

    The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long-standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to α,β-unsaturated aldehydes, to afford chiral 1,7-dioxo compounds with good yields and excellent regio- as well as enantioselectivity, has been developed.

  1. 77 FR 40948 - Additional Designation of Persons Whose Property and Interests in Property Are Blocked Pursuant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Persons Whose Property and Interests in... security situation and the persistence of violence in Somalia and acts of piracy and armed robbery at...

  2. 78 FR 50313 - Final Additional Airworthiness Design Standards: Night Visual Flight Rules (VFR) Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... Visual Flight Rules (VFR) Under the Special Class (JAR-VLA) Regulations; AQUILA Aviation by Excellence... visual flight rules (VFR) expansion and substantiation for the ] Aquila GmbH AT01. These additional... Airworthiness Design Standards: Night visual flight rules (VFR) Under the Special Class (JAR-VLA) Regulations...

  3. 77 FR 76490 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ...). ACTION: Notice. SUMMARY: HHS gives notice of a decision to designate a class of employees from the Oak Ridge National Laboratory (X-10) in Oak Ridge, Tennessee, as an addition to the Special Exposure Cohort... who worked in any area at the Oak Ridge National Laboratory (X-10) in Oak Ridge, Tennessee, from...

  4. Design and development of a layer-based additive manufacturing process for the realization of metal parts of designed mesostructure

    NASA Astrophysics Data System (ADS)

    Williams, Christopher Bryant

    Low-density cellular materials, metallic bodies with gaseous voids, are a unique class of materials that are characterized by their high strength, low mass, good energy absorption characteristics, and good thermal and acoustic insulation properties. In an effort to take advantage of this entire suite of positive mechanical traits, designers are tailoring the cellular mesostructure for multiple design objectives. Unfortunately, existing cellular material manufacturing technologies limit the design space as they are limited to certain part mesostructure, material type, and macrostructure. The opportunity that exists to improve the design of existing products, and the ability to reap the benefits of cellular materials in new applications is the driving force behind this research. As such, the primary research goal of this work is to design, embody, and analyze a manufacturing process that provides a designer the ability to specify the material type, material composition, void morphology, and mesostructure topology for any conceivable part geometry. The accomplishment of this goal is achieved in three phases of research: (1) Design---Following a systematic design process and a rigorous selection exercise, a layer-based additive manufacturing process is designed that is capable of meeting the unique requirements of fabricating cellular material geometry. Specifically, metal parts of designed mesostructure are fabricated via three-dimensional printing of metal oxide ceramic powder followed by post-processing in a reducing atmosphere. (2) Embodiment ---The primary research hypothesis is verified through the use of the designed manufacturing process chain to successfully realize metal parts of designed mesostructure. (3) Modeling & Evaluation ---The designed manufacturing process is modeled in this final research phase so as to increase understanding of experimental results and to establish a foundation for future analytical modeling research. In addition to an analysis of

  5. Design, methodology, and baseline data of the Personalized Addition Lenses Clinical Trial (PACT)

    PubMed Central

    Yu, Xinping; Zhang, Binjun; Bao, Jinhua; Zhang, Junxiao; Wu, Ge; Xu, Jinling; Zheng, Jingwei; Drobe, Björn; Chen, Hao

    2017-01-01

    Abstract Background: The aim of this study was to describe the design, methods, and baseline characteristics of children enrolled in the Personalized Addition lenses Clinical Trial (PACT). PACT aims to test the myopia control efficacy of progressive addition lenses (PALs) with personalized addition values compared with standard (+2.00 D) addition PALs and single vision lenses (SVLs). Methods: PACT is a randomized, controlled, double-masked clinical trial. Two hundred eleven myopic Chinese children (7–12 years) were enrolled and randomized into 1 of the 3 following groups: personalized addition PALs; +2.00 addition PALs; and SVLs. Personalized addition values were determined based on the highest addition that satisfied Sheard criterion. Axial length and other biometric data were also recorded. Results: At baseline, no differences were found between the right and left eyes for any of the main parameters. The enrolled children were 9.7 ± 1.1 years’ old with cycloplegic autorefraction (right eye [OD]: −2.36 ± 0.64 D), near phoria (1.0 ± 5.0 prism diopter esophoria), lag of accommodation (1.40 ± 0.50 D) and axial length (OD: 24.58 ± 0.74 mm). The personalized addition values ranged from +0.75 to +3.00 (average ± SD: 2.19 ± 0.73 D). Conclusion: PACT is a clinical trial evaluating whether myopia progression in children can be slowed by wearing personalized addition PALs compared with fixed addition PALs and SVLs as measured by cycloplegic autorefraction and axial length. Baseline data were comparable with those of previous myopia control studies in children. Subjects will be followed up every 6 months for 2 years. PMID:28296722

  6. Just-in-time Design and Additive Manufacture of Patient-specific Medical Implants

    NASA Astrophysics Data System (ADS)

    Shidid, Darpan; Leary, Martin; Choong, Peter; Brandt, Milan

    Recent advances in medical imaging and manufacturing science have enabled the design and production of complex, patient-specific orthopaedic implants. Additive Manufacture (AM) generates three-dimensional structures layer by layer, and is not subject to the constraints associated with traditional manufacturing methods. AM provides significant opportunities for the design of novel geometries and complex lattice structures with enhanced functional performance. However, the design and manufacture of patient-specific AM implant structures requires unique expertise in handling various optimization platforms. Furthermore, the design process for complex structures is computationally intensive. The primary aim of this research is to enable the just-in-time customisation of AM prosthesis; whereby AM implant design and manufacture be completed within the time constraints of a single surgical procedure, while minimising prosthesis mass and optimising the lattice structure to match the stiffness of the surrounding bone tissue. In this research, a design approach using raw CT scan data is applied to the AM manufacture of femoral prosthesis. Using the proposed just-in-time concept, the mass of the prosthesis was rapidly designed and manufactured while satisfying the associated structural requirements. Compressive testing of lattice structures manufactured using proposed method shows that the load carrying capacity of the resected composite bone can be recovered by up to 85% and the compressive stiffness of the AM prosthesis is statistically indistinguishable from the stiffness of the initial bone.

  7. Design, Development and Hotfire Testing of Monolithic Copper and Bimetallic Additively Manufactured Combustion Chambers

    NASA Technical Reports Server (NTRS)

    Gradl, Paul; Barnett, Greg; Brandsmeier, Will; Greene, Sandy Elam; Protz, Chris

    2016-01-01

    NASA and industry partners are working towards fabrication process development to reduce costs and schedules associated with manufacturing liquid rocket engine components with the goal of reducing overall mission costs. One such technique being evaluated is powder-bed fusion or selective laser melting (SLM) otherwise commonly referred to as additive manufacturing. The NASA Low Cost Upper Stage Propulsion (LCUSP) program was designed to develop processes and material characterization for the GRCop-84 copper-alloy commensurate with powder bed additive manufacturing, evaluate bimetallic deposition and complete testing of a full scale combustion chamber. As part of this development, the process has been transferred to industry partners to enable a long-term supply chain of monolithic copper combustion chambers. As a direct spin off of this program, NASA is working with industry partners to further develop the printing process for the GRCop-84 material in addition to the C-18150 (CuCrZr) material. To advance the process further and allow for optimization with multiple materials, NASA is also investigating the feasibility of bimetallic additively manufactured chambers. A 1.2k sized thrust-chamber was designed and developed to compare the printing process of the GRCop-84 and C-18150 SLM materials. A series of similar MCC liners also completed development with an Inconel 625 jacket bonded to the GRcop-84 liner evaluating direct metal deposition (DMD) laser and arc-based techniques. This paper describes the design, development, manufacturing and testing of these combustion chambers and associated lessons learned throughout the design and development process.

  8. The effect of alkaline additives on the performance of surfactant systems designed to recover light oils

    SciTech Connect

    French, T.R.; Josephson, C.B.; Evans, D.B.

    1991-02-01

    Surfactant flooding is flexible because of the ability to optimize formulations for a wide range of reservoir conditions and crude oil types. The objective for this work was to determine if the addition of alkaline additives will allow the design of surfactant formulations that are effective for the recovery of crude oil, while, at the same time, maintaining the surfactant concentration at a much lower level than has previously been used for micellar flooding. Specifically, the focus of the work was on light, midcontinent crudes that typically have very low acid contents. These oils are typical of much of the midcontinent resource. The positive effect of alkaline additives on the phase behavior of the surfactant formulations and acidic crude oils is well known. The extension to nonacidic and slightly acidic oils is not obvious. Three crude oils, a variety of commercial surfactants, and several alkaline additives were tested. The oils had acid numbers that ranged from 0.13, which is quite low, to less than 0.01 mg KOH/g of oil. Alkaline additives were found to be very effective in recovering Delaware-Childers (OK) oil at elevated temperatures, but much less effective at reservoir temperatures. Alkaline additives were very effective with Teapot Dome (WY) oil. With Teapot Dome oil, surfactant/alkali systems produced ultralow IFT values and recovered 60% of the residual oil that remained after waterflooding. The effect of alkaline additives on recovering Hepler (KS) oil was minimal. The results of this work indicate that alkaline additives do have merit for use in surfactant flooding of low acid crude oils; however, no universal statement about applicability can be made. Each oil behaves differently, with this treatment, and the effect of alkaline additives must be determined (at reservoir conditions) for each oil. 23 refs., 13 figs., 3 tabs.

  9. Numerical Method for the Design of Healing Chamber in Additive-Manufactured Dental Implants.

    PubMed

    Lee, Hsiao-Chien; Tsai, Pei-I; Huang, Chih-Chieh; Chen, San-Yuan; Chao, Chuen-Guang; Tsou, Nien-Ti

    2017-01-01

    The inclusion of a healing chamber in dental implants has been shown to promote biological healing. In this paper, a novel numerical approach to the design of the healing chamber for additive-manufactured dental implants is proposed. This study developed an algorithm for the modeling of bone growth and employed finite element method in ANSYS to facilitate the design of healing chambers with a highly complex configuration. The model was then applied to the design of dental implants for insertion into the posterior maxillary bones. Two types of ITI® solid cylindrical screwed implant with extra rectangular-shaped healing chamber as an initial design are adopted, with which to evaluate the proposed system. This resulted in several configurations for the healing chamber, which were then evaluated based on the corresponding volume fraction of healthy surrounding bone. The best of these implants resulted in a healing chamber surrounded by around 9.2% more healthy bone than that obtained from the original design. The optimal design increased the contact area between the bone and implant by around 52.9%, which is expected to have a significant effect on osseointegration. The proposed approach is highly efficient which typically completes the optimization of each implant within 3-5 days on an ordinary personal computer. It is also sufficiently general to permit extension to various loading conditions.

  10. Numerical Method for the Design of Healing Chamber in Additive-Manufactured Dental Implants

    PubMed Central

    Lee, Hsiao-Chien; Tsai, Pei-I; Huang, Chih-Chieh; Chen, San-Yuan; Chao, Chuen-Guang

    2017-01-01

    The inclusion of a healing chamber in dental implants has been shown to promote biological healing. In this paper, a novel numerical approach to the design of the healing chamber for additive-manufactured dental implants is proposed. This study developed an algorithm for the modeling of bone growth and employed finite element method in ANSYS to facilitate the design of healing chambers with a highly complex configuration. The model was then applied to the design of dental implants for insertion into the posterior maxillary bones. Two types of ITI® solid cylindrical screwed implant with extra rectangular-shaped healing chamber as an initial design are adopted, with which to evaluate the proposed system. This resulted in several configurations for the healing chamber, which were then evaluated based on the corresponding volume fraction of healthy surrounding bone. The best of these implants resulted in a healing chamber surrounded by around 9.2% more healthy bone than that obtained from the original design. The optimal design increased the contact area between the bone and implant by around 52.9%, which is expected to have a significant effect on osseointegration. The proposed approach is highly efficient which typically completes the optimization of each implant within 3–5 days on an ordinary personal computer. It is also sufficiently general to permit extension to various loading conditions. PMID:28293628

  11. Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review.

    PubMed

    Wang, Xiaojian; Xu, Shanqing; Zhou, Shiwei; Xu, Wei; Leary, Martin; Choong, Peter; Qian, M; Brandt, Milan; Xie, Yi Min

    2016-03-01

    One of the critical issues in orthopaedic regenerative medicine is the design of bone scaffolds and implants that replicate the biomechanical properties of the host bones. Porous metals have found themselves to be suitable candidates for repairing or replacing the damaged bones since their stiffness and porosity can be adjusted on demands. Another advantage of porous metals lies in their open space for the in-growth of bone tissue, hence accelerating the osseointegration process. The fabrication of porous metals has been extensively explored over decades, however only limited controls over the internal architecture can be achieved by the conventional processes. Recent advances in additive manufacturing have provided unprecedented opportunities for producing complex structures to meet the increasing demands for implants with customized mechanical performance. At the same time, topology optimization techniques have been developed to enable the internal architecture of porous metals to be designed to achieve specified mechanical properties at will. Thus implants designed via the topology optimization approach and produced by additive manufacturing are of great interest. This paper reviews the state-of-the-art of topological design and manufacturing processes of various types of porous metals, in particular for titanium alloys, biodegradable metals and shape memory alloys. This review also identifies the limitations of current techniques and addresses the directions for future investigations.

  12. Design of additive quantum codes via the code-word-stabilized framework

    NASA Astrophysics Data System (ADS)

    Kovalev, Alexey A.; Dumer, Ilya; Pryadko, Leonid P.

    2011-12-01

    We consider design of the quantum stabilizer codes via a two-step, low-complexity approach based on the framework of codeword-stabilized (CWS) codes. In this framework, each quantum CWS code can be specified by a graph and a binary code. For codes that can be obtained from a given graph, we give several upper bounds on the distance of a generic (additive or nonadditive) CWS code, and the lower Gilbert-Varshamov bound for the existence of additive CWS codes. We also consider additive cyclic CWS codes and show that these codes correspond to a previously unexplored class of single-generator cyclic stabilizer codes. We present several families of simple stabilizer codes with relatively good parameters.

  13. Theoretical and experimental investigation of design for multioptical-axis freeform progressive addition lenses

    NASA Astrophysics Data System (ADS)

    Xiang, HuaZhong; Chen, JiaBi; Zhu, TianFen; Wei, YeFei; Fu, DongXiang

    2015-11-01

    A freeform progressive addition lens (PAL) provides a good solution to correct presbyopia and prevent juvenile myopia by distributing pupils' optical powers of distance zone, near zone, and intermediate zone and is more widely adopted in the present optometric study. However, there is still a lack of a single-optical-axis system for the design of a PAL. This paper focuses on the research for an approach for designing a freeform PAL. A multioptical-axis system based on real viewing conditions using the eyes is employed for the representation of the freeform surface. We filled small pupils in the intermediate zone as a progressive corridor and the distance- and near-vision portions were defined as the standard spherical surfaces delimited by quadratic curves. Three freeform PALs with a spherical surface as the front side and a freeform surface as the backside were designed. We demonstrate the fabrication and measurement technologies for the PAL surface using computer numerical control machine tools from Schneider Smart and a Visionix VM-2000 Lens Power Mapper. Surface power and astigmatic values were obtained. Preliminary results showed that the approach for the design and fabrication is helpful to advance the design procedure optimization and mass production of PALs in optometry.

  14. On the design of novel multifunctional materials by using particulate additives

    NASA Astrophysics Data System (ADS)

    Dunnigan, Ross Daniel

    This thesis has been organized into five chapters. The main focus of this thesis is to design novel multifunctional materials by using particulate additives. Chapter 1 is devoted to reviewing recent studies in additive manufacturing (AM) and other background information. In Chapter 2, the synthesis and characterization of novel Ti3SiC2-reinforced Zn-matrix composites is reported. During this study, all the Zn composites were hot pressed at 500°C for 5 min at a uniaxial pressure of ~150 MPa. Microstructure analysis by SEM (Scanning Electron Microscopy) and phase analysis by XRD (X-ray Diffraction) confirmed that there was minimal interfacial reaction between Ti3SiC 2 particles and the Zn matrix. The addition of Ti3SiC 2 improved the tribological performance of these composites against alumina substrates but did not have any beneficial effect on the mechanical performance. The addition of Ti3SiC2 particulates to metal and polymer matrices show interesting properties. Chapter 3 will focus on additive manufacturing of Ti3SiC2 particulates in a polymer matrix. Waste materials are a big problem in the world. Chapters 4 and 5 focus on recycling materials. The mechanical and tribological properties of the Resin-Nylon and ResinPolyester composites are reported, respectively.

  15. PID Controller Design Based on Global Optimization Technique with Additional Constraints

    NASA Astrophysics Data System (ADS)

    Ozana, Stepan; Docekal, Tomas

    2016-05-01

    This paper deals with design of PID controller with the use of methods of global optimization implemented in Matlab environment and Optimization Toolbox. It is based on minimization of a chosen integral criterion with respect to additional requirements on control quality such as overshoot, phase margin and limits for manipulated value. The objective function also respects user-defined weigh coefficients for its particular terms for a different penalization of individual requirements that often clash each other such as for example overshoot and phase margin. The described solution is designated for continuous linear time-invariant static systems up to 4th order and thus efficient for the most of real control processes in practice.

  16. Evaluation of critical materials in five additional advance design photovoltaic cells

    SciTech Connect

    Smith, S.A.; Watts, R.L.; Martin, P.; Gurwell, W.E.

    1981-02-01

    The objective of this study is to identify potential material supply constraints due to the large-scale deployment of five advanced photovoltaic (PV) cell designs, and to suggest strategies to reduce the impacts of these production capacity limitations and potential future material shortages. The Critical Materials Assessment Program (CMAP) screens the designs and their supply chains and identifies potential shortages which might preclude large-scale use of the technologies. The results of the screening of five advanced PV cell designs are presented: (1) indium phosphide/cadmium sulfide, (2) zinc phosphide, (3) cadmium telluride/cadmium sulfide, (4) copper indium selenium, and (5) cadmium selenide photoelectrochemical. Each of these five cells is screened individually assuming that they first come online in 1991, and that 25 Gwe of peak capacity is online by the year 2000. A second computer screening assumes that each cell first comes online in 1991 and that each cell has a 5 GWe of peak capacity by the year 2000, so that the total online capacity for the five cells is 25 GWe. Based on a review of the preliminary baseline screening results, suggestions were made for varying such parameters as the layer thickness, cell production processes, etc. The resulting PV cell characterizations were then screened again by the CMAP computer code. The CMAP methodology used to identify critical materials is described; and detailed characterizations of the advanced photovoltaic cell designs under investigation, descriptions of additional cell production processes, and the results are presented. (WHK)

  17. A Novel Multiscale Design of Interfaces for Polymeric Composites and Bonded Joints using Additive Manufacturing

    DTIC Science & Technology

    2016-09-13

    AFRL-AFOSR-VA-TR-2016-0317 A Novel Multiscale Design of Interfaces for Polymeric Composites and Bonded Joints using Additive Manufacturing Pavana...PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8...PERFORMING ORGANIZATION REPORT NUMBER 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 9. SPONSORING/MONITORING AGENCY NAME(S) AND

  18. An identification method for enclosed voids restriction in manufacturability design for additive manufacturing structures

    NASA Astrophysics Data System (ADS)

    Liu, Shutian; Li, Quhao; Chen, Wenjiong; Tong, Liyong; Cheng, Gengdong

    2015-06-01

    Additive manufacturing (AM) technologies, such as selective laser sintering (SLS) and fused deposition modeling (FDM), have become the powerful tools for direct manufacturing of complex parts. This breakthrough in manufacturing technology makes the fabrication of new geometrical features and multiple materials possible. Past researches on designs and design methods often focused on how to obtain desired functional performance of the structures or parts, specific manufacturing capabilities as well as manufacturing constraints of AM were neglected. However, the inherent constraints in AM processes should be taken into account in design process. In this paper, the enclosed voids, one type of manufacturing constraints of AM, are investigated. In mathematics, enclosed voids restriction expressed as the solid structure is simplyconnected. We propose an equivalent description of simply-connected constraint for avoiding enclosed voids in structures, named as virtual temperature method (VTM). In this method, suppose that the voids in structure are filled with a virtual heating material with high heat conductivity and solid areas are filled with another virtual material with low heat conductivity. Once the enclosed voids exist in structure, the maximum temperature value of structure will be very high. Based upon this method, the simplyconnected constraint is equivalent to maximum temperature constraint. And this method can be easily used to formulate the simply-connected constraint in topology optimization. The effectiveness of this description method is illustrated by several examples. Based upon topology optimization, an example of 3D cantilever beam is used to illustrate the trade-off between manufacturability and functionality. Moreover, the three optimized structures are fabricated by FDM technology to indicate further the necessity of considering the simply-connected constraint in design phase for AM.

  19. Design and tuning of standard additive model based fuzzy PID controllers for multivariable process systems.

    PubMed

    Harinath, Eranda; Mann, George K I

    2008-06-01

    This paper describes a design and two-level tuning method for fuzzy proportional-integral derivative (FPID) controllers for a multivariable process where the fuzzy inference uses the inference of standard additive model. The proposed method can be used for any n x n multi-input-multi-output process and guarantees closed-loop stability. In the two-level tuning scheme, the tuning follows two steps: low-level tuning followed by high-level tuning. The low-level tuning adjusts apparent linear gains, whereas the high-level tuning changes the nonlinearity in the normalized fuzzy output. In this paper, two types of FPID configurations are considered, and their performances are evaluated by using a real-time multizone temperature control problem having a 3 x 3 process system.

  20. Half a degree additional warming, prognosis and projected impacts (HAPPI): background and experimental design

    NASA Astrophysics Data System (ADS)

    Mitchell, Daniel; AchutaRao, Krishna; Allen, Myles; Bethke, Ingo; Beyerle, Urs; Ciavarella, Andrew; Forster, Piers M.; Fuglestvedt, Jan; Gillett, Nathan; Haustein, Karsten; Ingram, William; Iversen, Trond; Kharin, Viatcheslav; Klingaman, Nicholas; Massey, Neil; Fischer, Erich; Schleussner, Carl-Friedrich; Scinocca, John; Seland, Øyvind; Shiogama, Hideo; Shuckburgh, Emily; Sparrow, Sarah; Stone, Dáithí; Uhe, Peter; Wallom, David; Wehner, Michael; Zaaboul, Rashyd

    2017-02-01

    The Intergovernmental Panel on Climate Change (IPCC) has accepted the invitation from the UNFCCC to provide a special report on the impacts of global warming of 1.5 °C above pre-industrial levels and on related global greenhouse-gas emission pathways. Many current experiments in, for example, the Coupled Model Inter-comparison Project (CMIP), are not specifically designed for informing this report. Here, we document the design of the half a degree additional warming, projections, prognosis and impacts (HAPPI) experiment. HAPPI provides a framework for the generation of climate data describing how the climate, and in particular extreme weather, might differ from the present day in worlds that are 1.5 and 2.0 °C warmer than pre-industrial conditions. Output from participating climate models includes variables frequently used by a range of impact models. The key challenge is to separate the impact of an additional approximately half degree of warming from uncertainty in climate model responses and internal climate variability that dominate CMIP-style experiments under low-emission scenarios.Large ensembles of simulations (> 50 members) of atmosphere-only models for three time slices are proposed, each a decade in length: the first being the most recent observed 10-year period (2006-2015), the second two being estimates of a similar decade but under 1.5 and 2 °C conditions a century in the future. We use the representative concentration pathway 2.6 (RCP2.6) to provide the model boundary conditions for the 1.5 °C scenario, and a weighted combination of RCP2.6 and RCP4.5 for the 2 °C scenario.

  1. Cloud-Based Automated Design and Additive Manufacturing: A Usage Data-Enabled Paradigm Shift

    PubMed Central

    Lehmhus, Dirk; Wuest, Thorsten; Wellsandt, Stefan; Bosse, Stefan; Kaihara, Toshiya; Thoben, Klaus-Dieter; Busse, Matthias

    2015-01-01

    Integration of sensors into various kinds of products and machines provides access to in-depth usage information as basis for product optimization. Presently, this large potential for more user-friendly and efficient products is not being realized because (a) sensor integration and thus usage information is not available on a large scale and (b) product optimization requires considerable efforts in terms of manpower and adaptation of production equipment. However, with the advent of cloud-based services and highly flexible additive manufacturing techniques, these obstacles are currently crumbling away at rapid pace. The present study explores the state of the art in gathering and evaluating product usage and life cycle data, additive manufacturing and sensor integration, automated design and cloud-based services in manufacturing. By joining and extrapolating development trends in these areas, it delimits the foundations of a manufacturing concept that will allow continuous and economically viable product optimization on a general, user group or individual user level. This projection is checked against three different application scenarios, each of which stresses different aspects of the underlying holistic concept. The following discussion identifies critical issues and research needs by adopting the relevant stakeholder perspectives. PMID:26703606

  2. Towards the design of new and improved drilling fluid additives using molecular dynamics simulations.

    PubMed

    Anderson, Richard L; Greenwel, H Christopher; Suter, James L; Jarvis, Rebecca M; Coveney, Peter V

    2010-03-01

    During exploration for oil and gas, a technical drilling fluid is used to lubricate the drill bit, maintain hydrostatic pressure, transmit sensor readings, remove rock cuttings and inhibit swelling of unstable clay based reactive shale formations. Increasing environmental awareness and resulting legislation has led to the search for new, improved biodegradable drilling fluid components. In the case of additives for clay swelling inhibition, an understanding of how existing effective additives interact with clays must be gained to allow the design of improved molecules. Owing to the disordered nature and nanoscopic dimension of the interlayer pores of clay minerals, computer simulations have become an increasingly useful tool for studying clay-swelling inhibitor interactions. In this work we briefly review the history of the development of technical drilling fluids, the environmental impact of drilling fluids and the use of computer simulations to study the interactions between clay minerals and swelling inhibitors. We report on results from some recent large-scale molecular dynamics simulation studies on low molecular weight water-soluble macromolecular inhibitor molecules. The structure and interactions of poly(propylene oxide)-diamine, poly(ethylene glycol) and poly(ethylene oxide)-diacrylate inhibitor molecules with montmorillonite clay are studied.

  3. Cloud-Based Automated Design and Additive Manufacturing: A Usage Data-Enabled Paradigm Shift.

    PubMed

    Lehmhus, Dirk; Wuest, Thorsten; Wellsandt, Stefan; Bosse, Stefan; Kaihara, Toshiya; Thoben, Klaus-Dieter; Busse, Matthias

    2015-12-19

    Integration of sensors into various kinds of products and machines provides access to in-depth usage information as basis for product optimization. Presently, this large potential for more user-friendly and efficient products is not being realized because (a) sensor integration and thus usage information is not available on a large scale and (b) product optimization requires considerable efforts in terms of manpower and adaptation of production equipment. However, with the advent of cloud-based services and highly flexible additive manufacturing techniques, these obstacles are currently crumbling away at rapid pace. The present study explores the state of the art in gathering and evaluating product usage and life cycle data, additive manufacturing and sensor integration, automated design and cloud-based services in manufacturing. By joining and extrapolating development trends in these areas, it delimits the foundations of a manufacturing concept that will allow continuous and economically viable product optimization on a general, user group or individual user level. This projection is checked against three different application scenarios, each of which stresses different aspects of the underlying holistic concept. The following discussion identifies critical issues and research needs by adopting the relevant stakeholder perspectives.

  4. Extracellular matrix protein in calcified endoskeleton: a potential additive for crystal growth and design

    NASA Astrophysics Data System (ADS)

    Azizur Rahman, M.; Fujimura, Hiroyuki; Shinjo, Ryuichi; Oomori, Tamotsu

    2011-06-01

    In this study, we demonstrate a key function of extracellular matrix proteins (ECMPs) on seed crystals, which are isolated from calcified endoskeletons of soft coral and contain only CaCO 3 without any living cells. This is the first report that an ECMP protein extracted from a marine organism could potentially influence in modifying the surface of a substrate for designing materials via crystallization. We previously studied with the ECMPs from a different type of soft coral ( Sinularia polydactyla) without introducing any seed crystals in the process , which showed different results. Thus, crystallization on the seed in the presence of ECMPs of present species is an important first step toward linking function to individual proteins from soft coral. For understanding this interesting phenomenon, in vitro crystallization was initiated in a supersaturated solution on seed particles of calcite (1 0 4) with and without ECMPs. No change in the crystal growth shape occurred without ECMPs present during the crystallization process. However, with ECMPs, the morphology and phase of the crystals in the crystallization process changed dramatically. Upon completion of crystallization with ECMPs, an attractive crystal morphology was found. Scanning electron microscopy (SEM) was utilized to observe the crystal morphologies on the seeds surface. The mineral phases of crystals nucleated by ECMPs on the seeds surface were examined by Raman spectroscopy. Although 50 mM Mg 2+ is influential in making aragonite in the crystallization process, the ECMPs significantly made calcite crystals even when 50 mM Mg 2+ was present in the process. Crystallization with the ECMP additive seems to be a technically attractive strategy to generate assembled micro crystals that could be used in crystals growth and design in the Pharmaceutical and biotechnology industries.

  5. Vacuum infusion equipment design and the influence of reinforcement layers addition to the resin infusion time

    NASA Astrophysics Data System (ADS)

    Saputra, A. H.; Setyarso, G.

    2016-11-01

    The characteristic of composite material is greatly influenced by the manufacture method of composite. The conventional method that has been used such as hand lay-up and spray up are simple and easy to apply but the composite tend to have a void in it because of the air trapped during the manufacture process. Vacuum infusion is one of the modern composite manufacture process which can replace the conventional method. The problem of this method happens when the resin infusion time become longer due to the addition of reinforcement layers. When the resin infusion time is longer than the resin's gel time, the resin will become gel and not able to flow into the mold. In order to overcome this problem, a study that observe the influence of reinforcement layers addition to the resin infusion time is needed. In this study, vacuum infusion equipment for composite materials manufacturing process that are designed consists of: 1×1m glass as the mold, 1L PVC tube for the resin container, 1L glass tube for the resin trap, and ‘A HP vacuum pump with 7 CFM vacuum speed. The resin that is used in this study is unsaturated polyester resin (UPR) and the fiber used as reinforcement is fiber glass. It is observed that the more number of reinforcement layers the longer resin infusion time will be. The resin infusion time (in seconds) from two until six layers respectively for the area of 15×20cm are: 88, 115, 145, 174, 196; for the area of 15×25cm are: 119, 142, 168, 198, 235; and for the area of 15×35cm are: 181, 203, 235, 263, 303. The maximum reinforcement layers that can be accommodated for each 15×20cm, 15×25cm, and 15×35cm area are respectively 31 layers, 29 layers, and 25 layers.

  6. Automated microbial metabolism laboratory. [design of advanced labeled release experiment based on single addition of soil and multiple sequential additions of media into test chambers

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The design and rationale of an advanced labeled release experiment based on single addition of soil and multiple sequential additions of media into each of four test chambers are outlined. The feasibility for multiple addition tests was established and various details of the methodology were studied. The four chamber battery of tests include: (1) determination of the effect of various atmospheric gases and selection of that gas which produces an optimum response; (2) determination of the effect of incubation temperature and selection of the optimum temperature for performing Martian biochemical tests; (3) sterile soil is dosed with a battery of C-14 labeled substrates and subjected to experimental temperature range; and (4) determination of the possible inhibitory effects of water on Martian organisms is performed initially by dosing with 0.01 ml and 0.5 ml of medium, respectively. A series of specifically labeled substrates are then added to obtain patterns in metabolic 14CO2 (C-14)O2 evolution.

  7. Additive Manufacturing, Design, Testing, and Fabrication: A Full Engineering Experience at JSC

    NASA Technical Reports Server (NTRS)

    Zusack, Steven

    2016-01-01

    I worked on several projects this term. While most projects involved additive manufacturing, I was also involved with two design projects, two testing projects, and a fabrication project. The primary mentor for these was Richard Hagen. Secondary mentors were Hai Nguyen, Khadijah Shariff, and fabrication training from James Brown. Overall, my experience at JSC has been successful and what I have learned will continue to help me in my engineering education and profession long after I leave. My 3D printing projects ranged from less than a 1 cubic centimeter to about 1 cubic foot and involved several printers using different printing technologies. It was exciting to become familiar with printing technologies such as industrial grade FDM (Fused Deposition Modeling), the relatively new SLA (Stereolithography), and PolyJet. My primary duty with the FDM printers was to model parts that came in from various sources to print effectively and efficiently. Using methods my mentor taught me and the Stratasys Insight software, I was able to minimize imperfections, hasten build time, improve strength for specific forces (tensile, shear, etc...), and reduce likelihood of a print-failure. Also using FDM, I learned how to repair a part after it was printed. This is done by using a special kind of glue that chemically melts the two faces of plastic parts together to form a fused interface. My first goal with SLA technology was to bring the printer back to operational readiness. In becoming familiar with the Pegasus SLA printer, I researched the leveling, laser settings, and different vats to hold liquid material. With this research, I was successfully able to bring the Pegasus back online and have successfully printed multiple sample parts as well as functional parts. My experience with PolyJet technology has been focused on an understanding of the abilities/limits, costs, and the maintenance for daily use. Still upcoming will be experience with using a composite printer that uses FDM

  8. An introduction to modeling longitudinal data with generalized additive models: applications to single-case designs.

    PubMed

    Sullivan, Kristynn J; Shadish, William R; Steiner, Peter M

    2015-03-01

    Single-case designs (SCDs) are short time series that assess intervention effects by measuring units repeatedly over time in both the presence and absence of treatment. This article introduces a statistical technique for analyzing SCD data that has not been much used in psychological and educational research: generalized additive models (GAMs). In parametric regression, the researcher must choose a functional form to impose on the data, for example, that trend over time is linear. GAMs reverse this process by letting the data inform the choice of functional form. In this article we review the problem that trend poses in SCDs, discuss how current SCD analytic methods approach trend, describe GAMs as a possible solution, suggest a GAM model testing procedure for examining the presence of trend in SCDs, present a small simulation to show the statistical properties of GAMs, and illustrate the procedure on 3 examples of different lengths. Results suggest that GAMs may be very useful both as a form of sensitivity analysis for checking the plausibility of assumptions about trend and as a primary data analysis strategy for testing treatment effects. We conclude with a discussion of some problems with GAMs and some future directions for research on the application of GAMs to SCDs.

  9. 10 CFR 60.133 - Additional design criteria for the underground facility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Technical Criteria Design Criteria for the Geologic Repository... waste. The underground facility shall be designed to permit retrieval of waste in accordance with the performance objectives of § 60.111. (d) Control of water and gas. The design of the underground facility...

  10. 76 FR 72928 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... decision to designate a class of employees from the Y-12 facility in Oak Ridge, Tennessee, as an addition... facility in Oak Ridge, Tennessee, during the period from January 1, 1948 through December 31, 1957, for...

  11. 76 FR 33762 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... decision to designate a class of employees from the Wah Chang facility, Albany, Oregon, as an addition to... who worked in any building at the Wah Chang facility in Albany, Oregon, for the operational...

  12. 77 FR 65310 - Additional Air Quality Designations for the 2006 24-Hour Fine Particle National Ambient Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... AGENCY 40 CFR Part 81 Additional Air Quality Designations for the 2006 24-Hour Fine Particle National Ambient Air Quality Standards AGENCY: Environmental Protection Agency (EPA). ACTION: Supplemental... particle (PM 2.5 ) national ambient air quality standards (NAAQS) air quality designations for the...

  13. 75 FR 51817 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... Safety and Health Final Effect of Designation of a Class of Employees for Addition to the Special... and Human Services (HHS). ACTION: Notice. SUMMARY: HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from BWX Technologies, Inc., in Lynchburg, Virginia,...

  14. 76 FR 7852 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... HUMAN SERVICES Final Effect of Designation of a Class of Employees for Addition to the Special Exposure... Human Services (HHS). ACTION: Notice. SUMMARY: HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from BWX Technologies, Inc., Lynchburg, Virginia, as an...

  15. 78 FR 21955 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ..., Division of Compensation Analysis and Support, NIOSH, 4676 Columbia Parkway, MS C-46, Cincinnati, OH 45226... U.S.C. 7384q(b), the Secretary of HHS designated the following class of employees as an addition to... Exposure Cohort. This designation became effective on April 5, 2013, as provided for under 42 U.S.C....

  16. 77 FR 69845 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees for Addition to the Special Exposure... notice concerning the final effect of the HHS decision to designate a class of employees from the...

  17. 75 FR 37812 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees for Addition to the Special Exposure... notice concerning the final effect of the HHS decision to designate a class of employees at the...

  18. 78 FR 70949 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees for Addition to the Special Exposure... notice concerning the final effect of the HHS decision to designate a class of employees from the...

  19. 78 FR 3897 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees for Addition to the Special Exposure... notice concerning the final effect of the HHS decision to designate a class of employees from the...

  20. 77 FR 58382 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... designate a class of employees from Winchester Engineering and Analytical Center in Winchester... Analytical Center in Winchester, Massachusetts, from January 1, 1952, through December 31, 1961, for a...

  1. 75 FR 22409 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Berkeley National Laboratory in Berkeley, California, as an addition to the Special Exposure Cohort (SEC... Lawrence Berkeley National Laboratory in Berkeley, California, from August 13, 1942 through December...

  2. Modeling Longitudinal Data with Generalized Additive Models: Applications to Single-Case Designs

    ERIC Educational Resources Information Center

    Sullivan, Kristynn J.; Shadish, William R.

    2013-01-01

    Single case designs (SCDs) are short time series that assess intervention effects by measuring units repeatedly over time both in the presence and absence of treatment. For a variety of reasons, interest in the statistical analysis and meta-analysis of these designs has been growing in recent years. This paper proposes modeling SCD data with…

  3. 77 FR 58381 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... designate a class of employees from Clarksville Modification Center, Ft. Campbell, in Clarksville, Tennessee... Campbell, in Clarksville, Tennessee, from August 1, 1949, through December 31, 1967, for a number of...

  4. 76 FR 68460 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... Ames Laboratory at Iowa State University during the period from August 13, 1942 through December 31...). ACTION: Notice. SUMMARY: HHS gives notice of a decision to designate a class of employees from the...

  5. 77 FR 76489 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ...). ACTION: Notice. SUMMARY: HHS gives notice of a decision to designate a class of employees from the Mound... Mound Plant in Miamisburg, Ohio, from September 1, 1972, through December 31, 1972, or from January...

  6. 75 FR 44967 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-30

    ...: Notice. SUMMARY: HHS gives notice of a decision to designate a class of employees from the Mound Plant in... worked at the Mound Plant in Miamisburg, Ohio from March 1, 1959 through March 5, 1980, for a number...

  7. 10 CFR 60.133 - Additional design criteria for the underground facility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... specific site conditions identified through in situ monitoring, testing, or excavation. (c) Retrieval of waste. The underground facility shall be designed to permit retrieval of waste in accordance with...

  8. 10 CFR 60.133 - Additional design criteria for the underground facility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... specific site conditions identified through in situ monitoring, testing, or excavation. (c) Retrieval of waste. The underground facility shall be designed to permit retrieval of waste in accordance with...

  9. 77 FR 32641 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... designate a class of employees from the Electro Metallurgical site in Niagara Falls, New York, as an... their contractors and subcontractors who worked at the Electro Metallurgical site in Niagara Falls,...

  10. 76 FR 51035 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ...). ACTION: Notice. SUMMARY: HHS gives notice of a decision to designate a class of employees from Sandia... at the Sandia National Laboratories in Albuquerque, New Mexico, from January 1, 1949 through...

  11. 75 FR 22410 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ...). ACTION: Notice. SUMMARY: HHS gives notice of a decision to designate a class of employees at Westinghouse... Employer employees who worked at Westinghouse Electric Corp., Bloomfield, New Jersey, from August 13,...

  12. 76 FR 3907 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... Chemicals, Inc., Texas City, Texas, as an addition to the Special Exposure Cohort (SEC) under the Energy... who worked at Texas City Chemicals, Inc., from October 5, 1953, through September 30, 1955, for...

  13. 76 FR 26299 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... Linde Ceramics Plant in Tonawanda, New York, as an addition to the Special Exposure Cohort (SEC) under... Employees who worked at the Linde Ceramics Plant in Tonawanda, New York, from January 1, 1954...

  14. 77 FR 40059 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... as the Fernald Environmental Management Project (FEMP), as an addition to the Special Exposure Cohort... Production Center (FMPC) in Fernald, Ohio, also known as the Fernald Environmental Management Project...

  15. 76 FR 68459 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... facility in Oak Ridge, Tennessee, as an addition to the Special Exposure Cohort (SEC) under the Energy... facility in Oak Ridge, Tennessee, during the period from January 1, 1948 through December 31, 1957, for...

  16. 76 FR 68459 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... and Company in Curtis Bay, Maryland, as an addition to the Special Exposure Cohort (SEC) under the... Employees who worked at any building or area at the facility owned by W.R. Grace and Company in Curtis...

  17. 76 FR 28436 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Chang facility in Albany, Oregon, as an addition to the Special Exposure Cohort (SEC) under the Energy... who worked in any building at the Wah Chang facility in Albany, Oregon, for the operational...

  18. CHARMM additive and polarizable force fields for biophysics and computer-aided drug design

    PubMed Central

    Vanommeslaeghe, K.

    2014-01-01

    Background Molecular Mechanics (MM) is the method of choice for computational studies of biomolecular systems owing to its modest computational cost, which makes it possible to routinely perform molecular dynamics (MD) simulations on chemical systems of biophysical and biomedical relevance. Scope of Review As one of the main factors limiting the accuracy of MD results is the empirical force field used, the present paper offers a review of recent developments in the CHARMM additive force field, one of the most popular bimolecular force fields. Additionally, we present a detailed discussion of the CHARMM Drude polarizable force field, anticipating a growth in the importance and utilization of polarizable force fields in the near future. Throughout the discussion emphasis is placed on the force fields’ parametrization philosophy and methodology. Major Conclusions Recent improvements in the CHARMM additive force field are mostly related to newly found weaknesses in the previous generation of additive force fields. Beyond the additive approximation is the newly available CHARMM Drude polarizable force field, which allows for MD simulations of up to 1 microsecond on proteins, DNA, lipids and carbohydrates. General Significance Addressing the limitations ensures the reliability of the new CHARMM36 additive force field for the types of calculations that are presently coming into routine computational reach while the availability of the Drude polarizable force fields offers a model that is an inherently more accurate model of the underlying physical forces driving macromolecular structures and dynamics. PMID:25149274

  19. Rational Design of Solution Additives for the Prevention of Protein Aggregation

    PubMed Central

    Baynes, Brian M.; Trout, Bernhardt L.

    2004-01-01

    We have developed a statistical-mechanical model of the effect of solution additives on protein association reactions. This model incorporates solvent radial distribution functions obtained from all-atom molecular dynamics simulations of particular proteins into simple models of protein interactions. In this way, the effects of additives can be computed along the entire association/dissociation reaction coordinate. We used the model to test our hypothesis that a class of large solution additives, which we term “neutral crowders,” can slow protein association and dissociation by being preferentially excluded from protein-protein encounter complexes, in a manner analogous to osmotic stress. The magnitude of this proposed “gap effect” was probed for two simple model systems: the association of two spheres and the association of two planes. Our results suggest that for a protein of 20 Å radius, an 8 Å additive can increase the free energy barrier for association and dissociation by as much as 3–6 kcal/mol. Because the proposed gap effect is present only for reactions involving multiple molecules, it can be exploited to develop novel additives that affect protein association reactions although having little or no effect on unimolecular reactions such as protein folding. This idea has many potential applications in areas such as the stabilization of proteins against aggregation during folding and in pharmaceutical formulations. PMID:15345542

  20. Rational design of solution additives for the prevention of protein aggregation.

    PubMed

    Baynes, Brian M; Trout, Bernhardt L

    2004-09-01

    We have developed a statistical-mechanical model of the effect of solution additives on protein association reactions. This model incorporates solvent radial distribution functions obtained from all-atom molecular dynamics simulations of particular proteins into simple models of protein interactions. In this way, the effects of additives can be computed along the entire association/dissociation reaction coordinate. We used the model to test our hypothesis that a class of large solution additives, which we term "neutral crowders," can slow protein association and dissociation by being preferentially excluded from protein-protein encounter complexes, in a manner analogous to osmotic stress. The magnitude of this proposed "gap effect" was probed for two simple model systems: the association of two spheres and the association of two planes. Our results suggest that for a protein of 20 A radius, an 8 A additive can increase the free energy barrier for association and dissociation by as much as 3-6 kcal/mol. Because the proposed gap effect is present only for reactions involving multiple molecules, it can be exploited to develop novel additives that affect protein association reactions although having little or no effect on unimolecular reactions such as protein folding. This idea has many potential applications in areas such as the stabilization of proteins against aggregation during folding and in pharmaceutical formulations.

  1. Large Advanced Space Systems (LASS) computer-aided design program additions

    NASA Technical Reports Server (NTRS)

    Farrell, C. E.

    1982-01-01

    The LSS preliminary and conceptual design requires extensive iteractive analysis because of the effects of structural, thermal, and control intercoupling. A computer aided design program that will permit integrating and interfacing of required large space system (LSS) analyses is discussed. The primary objective of this program is the implementation of modeling techniques and analysis algorithms that permit interactive design and tradeoff studies of LSS concepts. Eight software modules were added to the program. The existing rigid body controls module was modified to include solar pressure effects. The new model generator modules and appendage synthesizer module are integrated (interfaced) to permit interactive definition and generation of LSS concepts. The mass properties module permits interactive specification of discrete masses and their locations. The other modules permit interactive analysis of orbital transfer requirements, antenna primary beam n, and attitude control requirements.

  2. Laser and electron-beam powder-bed additive manufacturing of metallic implants: A review on processes, materials and designs.

    PubMed

    Sing, Swee Leong; An, Jia; Yeong, Wai Yee; Wiria, Florencia Edith

    2016-03-01

    Additive manufacturing (AM), also commonly known as 3D printing, allows the direct fabrication of functional parts with complex shapes from digital models. In this review, the current progress of two AM processes suitable for metallic orthopaedic implant applications, namely selective laser melting (SLM) and electron beam melting (EBM) are presented. Several critical design factors such as the need for data acquisition for patient-specific design, design dependent porosity for osteo-inductive implants, surface topology of the implants and design for reduction of stress-shielding in implants are discussed. Additive manufactured biomaterials such as 316L stainless steel, titanium-6aluminium-4vanadium (Ti6Al4V) and cobalt-chromium (CoCr) are highlighted. Limitations and future potential of such technologies are also explored.

  3. 76 FR 73758 - Additional Designation of Four Entities Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ...: Designation of Nuclear Reactors Fuel Company (SUREH), Noor Afzar Gostar Company (NAGCO), Fulmen Group, and... determined that four Iranian entities, Nuclear Reactors Fuel Company (SUREH), Noor Afzar Gostar Company... NUCLEAR REACTORS FUEL COMPANY (a.k.a.: SUREH. Location: 61 Shahid Abtahi St., Karegar e Shomali,...

  4. 10 CFR 60.133 - Additional design criteria for the underground facility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... specific site conditions identified through in situ monitoring, testing, or excavation. (c) Retrieval of... deleterious rock movement or fracturing of overlying or surrounding rock. (f) Rock excavation. The design of the underground facility shall incorporate excavation methods that will limit the potential...

  5. 78 FR 54791 - Proposed Additional Airworthiness Design Standards: Advanced Avionics Under the Special Class...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ... current regulations only address traditional federated gauges. The European Aviation Safety Agency (EASA... through EASA special conditions or new regulations. These Federal Aviation Administration (FAA) design... overburdensome and to encourage EASA to follow suit. DATES: Comments must be received on or before October...

  6. 76 FR 52384 - Designation of Additional Entities Pursuant to Executive Order 13405

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... Democratic Processes or Institutions in Belarus.'' DATES: The designation by the Director of OFAC of the four... repression, electoral fraud, and public corruption in Belarus. The Order imposes economic sanctions on persons responsible for actions or policies that undermine democratic processes or institutions in...

  7. 75 FR 44968 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-30

    ... Airport Storage Site in St. Louis, Missouri, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On July 14, 2010, the Secretary... Department of Energy, its predecessor agencies, and its contractors and subcontractors who worked in any...

  8. Design of additive quantum codes via the codeword-stabilized framework

    NASA Astrophysics Data System (ADS)

    Pryadko, Leonid P.; Dumer, Ilya; Kovalev, Alexey A.

    2012-02-01

    Codeword stabilized (CWS) construction defines a quantum code by combining a classical binary code with some underlying graph state. In general, CWS codes are non-additive but become additive stabilizer codes if derived from a linear binary code. Generic CWS codes typically require complex error correction; however, we show that the CWS framework is an efficient tool for constructing good stabilizer codes with simple decoding. We start by proving the lower Gilbert-Varshamov bound on the parameters of an additive CWS code which can be obtained from a given graph. We also show that cyclic additive CWS codes belong to a previously overlooked family of single-generator cyclic stabilizer codes; these codes are derived from a circulant graph and a cyclic binary code. Finally, we present several families of simple stabilizer codes with relatively good parameters, including a family of the smallest toric-like cyclic CWS codes which have length, dimension, and distance as follows: [[t^2+(t+1)^2,1,2t+1

  9. 77 FR 58911 - Additional Identifying Information for One (1) Individual Designated Pursuant to Executive Order...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... Threaten to Disrupt the Middle East Peace Process'' (the ``Order''). DATES: The addition by the Director of... sanctions on persons who threaten to disrupt the Middle East peace process. The President identified in the... Middle East peace ] process; or (2) assist in, sponsor, or provide financial, material, or...

  10. 75 FR 22410 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Livermore National Laboratory in Livermore, California, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On April 5, 2010, the... Department of Energy, its predecessor agencies, and their contractors and subcontractors who worked at...

  11. 75 FR 44966 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-30

    ... Soto Avenue Facility in Los Angeles County, California, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On July 14... employees of the Department of Energy, its predecessor agencies, and their contractors and...

  12. Designing Location-Based Learning Experiences for People with Intellectual Disabilities and Additional Sensory Impairments

    ERIC Educational Resources Information Center

    Brown, David J.; McHugh, David; Standen, Penny; Evett, Lindsay; Shopland, Nick; Battersby, Steven

    2011-01-01

    The research reported here is part of a larger project which seeks to combine serious games (or games-based learning) with location-based services to help people with intellectual disabilities and additional sensory impairments to develop work based skills. Specifically this paper reports on where these approaches are combined to scaffold the…

  13. 76 FR 7852 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from Simonds Saw and Steel Co., Lockport, New York, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On January 6, 2011, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following......

  14. 77 FR 38835 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Brookhaven National Laboratory in Upton, New York, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On May 11, 2012, as provided for under 42 U.S.C. Sec. 7384q(b), the Secretary of HHS designated the......

  15. 76 FR 7852 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from Texas City Chemicals, Inc., Texas City, Texas, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On January 6, 2011, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following......

  16. 76 FR 72928 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from Vitro Manufacturing in Canonsburg, Pennsylvania, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On October 18, 2011, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following......

  17. 77 FR 38835 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Sandia National Laboratories in Albuquerque, New Mexico, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On May 11, 2012, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the......

  18. 76 FR 59701 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Sandia National Laboratories, Albuquerque, New Mexico, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On July 29, 2011, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the......

  19. 77 FR 38835 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Electro Metallurgical site in Niagara Falls, New York, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On May 11, 2012, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the......

  20. 77 FR 5254 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Pantex Plant in Amarillo, Texas, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On December 21, 2011, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following class of......

  1. Design of a Soil Science practical exercise to understand the soil carbon sequestration after biochar addition

    NASA Astrophysics Data System (ADS)

    Gascó, Gabriel; Cely, Paola; Saa-Requejo, Antonio; Mendez, Ana; Antón, Jose Manuel; Sánchez, Elena; Moratiel, Ruben; Tarquis, Ana M.

    2014-05-01

    The adaptation of the Universities to European Higher Education Area (EHEA) involves changes in the learning system. Students must obtain specific capabilities in the different degrees or masters. For example, in the degree of Agronomy at the Universidad Politécnica de Madrid (UPM, Spain), they must command Soil science, Mathematics or English. Sometimes, There is not a good communication between teachers and it causes that students do not understand the importance of the different subjects of a career. For this reason, teachers of the Soil Science and Mathematics Departments of the UPM designed a common practice to teach to the students the role of soil on the carbon sequestration. The objective of this paper is to explain the followed steps to the design of the practice. Acknowledgement to Universidad Politécnica de Madrid for the Projects in Education Innovation IE12_13-02009 and IE12_13-02012.

  2. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

    PubMed Central

    Moehle, Erica A.; Rock, Jeremy M.; Lee, Ya-Li; Jouvenot, Yann; DeKelver, Russell C.; Gregory, Philip D.; Urnov, Fyodor D.; Holmes, Michael C.

    2007-01-01

    Efficient incorporation of novel DNA sequences into a specific site in the genome of living human cells remains a challenge despite its potential utility to genetic medicine, biotechnology, and basic research. We find that a precisely placed double-strand break induced by engineered zinc finger nucleases (ZFNs) can stimulate integration of long DNA stretches into a predetermined genomic location, resulting in high-efficiency site-specific gene addition. Using an extrachromosomal DNA donor carrying a 12-bp tag, a 900-bp ORF, or a 1.5-kb promoter-transcription unit flanked by locus-specific homology arms, we find targeted integration frequencies of 15%, 6%, and 5%, respectively, within 72 h of treatment, and with no selection for the desired event. Importantly, we find that the integration event occurs in a homology-directed manner and leads to the accurate reconstruction of the donor-specified genotype at the endogenous chromosomal locus, and hence presumably results from synthesis-dependent strand annealing repair of the break using the donor DNA as a template. This site-specific gene addition occurs with no measurable increase in the rate of random integration. Remarkably, we also find that ZFNs can drive the addition of an 8-kb sequence carrying three distinct promoter-transcription units into an endogenous locus at a frequency of 6%, also in the absence of any selection. These data reveal the surprising versatility of the specialized polymerase machinery involved in double-strand break repair, illuminate a powerful approach to mammalian cell engineering, and open the possibility of ZFN-driven gene addition therapy for human genetic disease. PMID:17360608

  3. Additional Drug Resistance Patterns among Multidrug-Resistant Tuberculosis Patients in Korea: Implications for Regimen Design

    PubMed Central

    2017-01-01

    Detailed information on additional drug resistance patterns of multidrug-resistant tuberculosis (MDR-TB) is essential to build an effective treatment regimen; however, such data are scarce in Korea. We retrospectively analyzed the results of phenotypic drug susceptibility testing (DST) of culture confirmed-TB patients from January 2010 to December 2014 in 7 university hospitals in Korea. MDR-TB was identified among 6.8% (n = 378) of 5,599 isolates. A total of 57.1% (n = 216) of the MDR-TB patients had never been treated for TB. Strains from MDR-TB patients showed additional resistance to pyrazinamide (PZA) (35.7%), any second-line injectable drug (19.3%), and any fluoroquinolone (26.2%). Extensively drug resistant TB comprised 12.4% (n = 47) of the MDR-TB patients. Of 378 MDR-TB patients, 50.3% (n = 190) were eligible for the shorter MDR-TB regimen, and 50.0% (n = 189) were fully susceptible to the 5 drugs comprising the standard conventional regimen (PZA, kanamycin, ofloxoacin, prothionamide, and cycloserine). In conclusion, the proportion of new patients and the levels of additional drug resistance were high in MDR-TB patients. Considering the high levels of drug resistance, the shorter MDR-TB treatment regimen may not be feasible; instead, an individually tailored regimen based on the results of molecular and phenotypic DST may be more appropriate in MDR-TB patients in Korea. PMID:28244290

  4. Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design.

    PubMed

    Keller, Matthew C; Coventry, William L; Heath, Andrew C; Martin, Nicholas G

    2005-11-01

    Studies using the classical twin design often conclude that most genetic variation underlying personality is additive in nature. However, studies analyzing only twins are very limited in their ability to detect non-additive genetic variation and are unable to detect sources of variation unique to twins, which can mask non-additive genetic variation. The current study assessed 9672 MZ and DZ twin individuals and 3241 of their siblings to investigate the environmental and genetic architecture underlying eight dimensions of personality: four from Eysenck's Personality Questionnaire and four from Cloninger's Temperament and Character Inventory. Broad-sense heritability estimates from best-fitting models were two to three times greater than the narrow-sense heritability estimates for Harm Avoidance, Novelty Seeking, Reward Dependence, Persistence, Extraversion, and Neuroticism. This genetic non-additivity could be due to dominance, additive-by-additive epistasis, or to additive genetic effects combined with higher-order epistasis. Environmental effects unique to twins were detected for both Lie and Psychoticism but accounted for little overall variation. Our results illustrate the increased sensitivity afforded by extending the classical twin design to include siblings, and may provide clues to the evolutionary origins of genetic variation underlying personality.

  5. Novel Overhang Support Designs for Powder-Based Electron Beam Additive Manufacturing (EBAM)

    NASA Technical Reports Server (NTRS)

    Nabors, Sammy A.

    2014-01-01

    NASA Marshall Space Flight Center, in collaboration with the University of Alabama, has developed a contact-free support structure used to fabricate overhang-type geometries via EBAM. The support structure is used for 3-D metal-printed components for the aerospace, automotive, biomedical and other industries. Current techniques use support structures to address deformation challenges inherent in 3-D metal printing. However, these structures (overhangs) are bonded to the component and need to be removed in post-processing using a mechanical tool. This new technology improves the overhang support structure design for components by eliminating associated geometric defects and post-processing requirements.

  6. 78 FR 70949 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Feed Materials Production Center (FMPC) in Fernald, Ohio, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of...

  7. 78 FR 70949 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Pantex Plant in Amarillo, Texas, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of...

  8. 76 FR 47646 - Additional Designation of Person Whose Property and Interests in Property Are Blocked Pursuant to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Person Whose Property and Interests in... piracy and armed robbery at sea off the coast of Somalia. Section 1 of the Order blocks, with...

  9. 76 FR 47647 - Additional Designation of Person Whose Property and Interests in Property Are Blocked Pursuant to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Person Whose Property and Interests in... piracy and armed robbery at sea off the coast of Somalia. Section 1 of the Order blocks, with...

  10. 75 FR 51817 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... decision to designate a class of employees from the St. Louis Airport Storage Site in St. Louis, Missouri, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness... Department of Energy, its predecessor agencies, and its contractors and subcontractors who worked in any...

  11. Testing for Additivity in Chemical Mixtures Using a Fixed-Ratio Ray Design and Statistical Equivalence Testing Methods

    EPA Science Inventory

    Fixed-ratio ray designs have been used for detecting and characterizing interactions of large numbers of chemicals in combination. Single chemical dose-response data are used to predict an “additivity curve” along an environmentally relevant ray. A “mixture curve” is estimated fr...

  12. 77 FR 60437 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ... Analysis and Support, NIOSH, 4676 Columbia Parkway, MS C-46, Cincinnati, OH 45226, Telephone 877-222-7570... 42 U.S.C. 7384q(b), the Secretary of HHS designated the following class of employees as an addition... effective on September 22, 2012, as provided for under 42 U.S.C. 7384l(14)(C). Hence, beginning on...

  13. 75 FR 27784 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... concerning the final effect of the decision to designate a class of employees at the Lawrence Berkeley National Laboratory in Berkeley, California, as an addition to the Special Exposure Cohort (SEC) under the..., and their contractors and subcontractors who worked at the Lawrence Berkeley National Laboratory...

  14. Determining a Robust D-Optimal Design for Testing for Departure from Additivity in a Mixture of Four Perfluoroalkyl Acids.

    EPA Science Inventory

    Our objective is to determine an optimal experimental design for a mixture of perfluoroalkyl acids (PFAAs) that is robust to the assumption of additivity. PFAAs are widely used in consumer products and industrial applications. The presence and persistence of PFAAs, especially in ...

  15. DETERMINING A ROBUST D-OPTIMAL DESIGN FOR TESTING FOR DEPARTURE FROM ADDITIVITY IN A MIXTURE OF FOUR PFAAS

    EPA Science Inventory

    Our objective was to determine an optimal experimental design for a mixture of perfluoroalkyl acids (PFAAs) that is robust to the assumption of additivity. Of particular focus to this research project is whether an environmentally relevant mixture of four PFAAs with long half-liv...

  16. 78 FR 3898 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... notice concerning the final effect of the HHS decision to designate a class of employees from Oak Ridge National Laboratory (X-10), in Oak Ridge, Tennessee, as an addition to the Special Exposure Cohort (SEC..., and their contractors and subcontractors who worked in any area at the Oak Ridge National...

  17. 75 FR 3469 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... notice concerning the final effect of the HHS decision to designate a class of employees at the Oak Ridge Hospital in Oak Ridge, Tennessee, as an addition to the Special Exposure Cohort (SEC) under the Energy... and subcontractors who worked in any location at the Oak Ridge Hospital in Oak Ridge, Tennessee,...

  18. 75 FR 67364 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees for Addition to the Special Exposure... Human Services (HHS). ACTION: Notice. SUMMARY: HHS gives notice concerning the final effect of the...

  19. Additional testing of the inlets designed for a tandem fan V/STOL nacelle

    NASA Technical Reports Server (NTRS)

    Ybarra, A. H.

    1981-01-01

    The wind tunnel testing of a scale model of a tandem fan nacelle designed for a type (subsonic cruise) V/STOL aircraft configuration is discussed. The performance for the isolated front inlet and for the combined front and aft inlets is reported. Model variables include front and aft inlets with aft inlet variations of short and long aft inlet cowls, with a shaft simulator and diffuser vortex generators, cowl lip fillets, and nacelle strakes. Inlet pressure recovery, distortion, and inlet angle-to-attack separation limits were evaluated at tunnel velocity from 0 to 240 knots, angles-of-attack from -10 to +40 degrees and inlet flow rates corresponding to throat Mach number from 0.0 to 0.6. Combined nacelle pitch and yaw runs up to 30 deg. were also made.

  20. Design rules for rational control of polymer glass formation behavior and mechanical properties with small molecular additives

    NASA Astrophysics Data System (ADS)

    Mangalara, Jayachandra Hari; Simmons, David

    Small molecule additives have long been employed to tune polymers' glass formation, mechanical and transport properties. For example, plasticizers are commonly employed to suppress polymer Tg and soften the glassy state, while antiplasticizers, which stiffen the glassy state of a polymer while suppressing its Tg, are employed to enhance protein and tissue preservation in sugar glasses. Recent literature indicates that additives can have a wide range of possible effects, but all of these have not been clearly understood and well appreciated. Here we employ molecular dynamics simulations to establish design rules for the selection of small molecule additives with size, molecular stiffness, and interaction energy chosen to achieve targeted effects on polymer properties. We furthermore find that a given additive's effect on a polymer's Tg can be predicted from its Debye-Waller factor via a function previously found to describe nanoconfinement effects on the glass transition. These results emphasize the potential for a new generation of targeted molecular additives to contribute to more targeted rational design of polymers. We acknowledge the Keck Foundation and the Ohio Supercomputing Center for financial and computational support of this effort, respectively.

  1. 75 FR 3470 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...The Department of Health and Human Services (HHS) gives notice concerning the final effect of the HHS decision to designate a class of employees at the Brookhaven National Laboratory in Upton, New York, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On December 10, 2009, as provided for under 42 U.S.C.......

  2. 75 FR 3470 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...The Department of Health and Human Services (HHS) gives notice concerning the final effect of the HHS decision to designate a class of employees at the Metals and Controls Corp. in Attleboro, Massachusetts, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On December 10, 2009, as provided for under 42 U.S.C.......

  3. 75 FR 3469 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...The Department of Health and Human Services (HHS) gives notice concerning the final effect of the HHS decision to designate a class of employees at the Hanford site in Richland, Washington, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On December 10, 2009, as provided for under 42 U.S.C. 7384q(b), the......

  4. 75 FR 3469 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...The Department of Health and Human Services (HHS) gives notice concerning the final effect of the HHS decision to designate a class of employees at the Piqua Organic Moderated Reactor site in Piqua, Ohio, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On December 10, 2009, as provided for under 42 U.S.C.......

  5. Magneto-rheological fluids redispersibility - a factorial design study of phosphate shell on carbonyl iron powder with dispersing additives

    NASA Astrophysics Data System (ADS)

    Bombard, Antonio J. F.; Antunes, Laís S.; Balestrassi, Pedro P.; Paiva, Anderson P.

    2009-02-01

    We showed, in a previous paper, that Magneto-Rheological Fluids (MRFs) have different rheology when prepared with Carbonyl Iron Powders (CIP) phosphate (coated or uncoated). This was especially so when done without a magnetic field. This paper employs factorial design to examine the redispersibility and rheology of some MRF formulations; we use the same CIPs but with different dispersing additives. The factors are: CIP A (uncoated) or B (phosphate shell); additives with carboxylic acid or primary amine as the polar group; and n-octyl (C8H17) or n-dodecyl (C12H25) as the alkyl hydrocarbon chain (R-). CIP B was much more redispersible than CIP A, especially with amine additives; typical work values were > 5mJ @ 20 mm depth. In terms of viscosity, CIP A generated lower values, at shear rates above 100 s-1. It also realized higher yield stress values (Ho = 300 kA/m) than CIP B (50% and beyond).

  6. Effect of Additives on Green Sand Molding Properties using Design of Experiments and Taguchi's Quality Loss Function - An Experimental Study

    NASA Astrophysics Data System (ADS)

    Desai, Bhagyashree; Mokashi, Pavani; Anand, R. L.; Burli, S. B.; Khandal, S. V.

    2016-09-01

    The experimental study aims to underseek the effect of various additives on the green sand molding properties as a particular combination of additives could yield desired sand properties. The input parameters (factors) selected were water and powder (Fly ash, Coconut shell and Tamarind) in three levels. Experiments were planned using design of experiments (DOE). On the basis of plans, experiments were conducted to understand the behavior of sand mould properties such as compression strength, shear strength, permeability number with various additives. From the experimental results it could be concluded that the factors have significant effect on the sand properties as P-value found to be less than 0.05 for all the cases studied. The optimization based on quality loss function was also performed. The study revealed that the quality loss associated with the tamarind powder was lesser compared to other additives selected for the study. The optimization based on quality loss function and the parametric analysis using ANOVA suggested that the tamarind powder of 8 gm per Kg of molding sand and moisture content of 7% yield better properties to obtain sound castings.

  7. A Comparison of Dimensional Accuracy of Addition Silicone of Different Consistencies with Two Different Spacer Designs - In-vitro Study

    PubMed Central

    Eswaran, B; Eswaran, MA; Prabhu, R; Geetha, KR; Krishna, GP; Jagadeshwari

    2014-01-01

    Introduction: Dimensional accuracy of impression materials is crucial for the production of working casts in Fixed Prosthodontics. The accurate replication of tooth preparations and their arch position requires impression materials that exhibit limited distortion. Methods: This study was conducted to comparatively evaluate the dimensional accuracy of additional silicones by comparing two different techniques and spacer designs, by measuring the linear changes in interpreparation distance. The impressions were made from a stainless steel master die simulating a three unit bridge. A total 80 die stone (type IV, Ultrarock) models were obtained from the impressions made using two different parameters. The two different parameters are Multimix and Monophasic technique and different spacer designs. Result: The interpreparation distance of the abutments in the casts was measured using a travelling microscope. Each sample was measured thrice and the mean value was calculated. The results obtained were statistically analysed and the values fall within the clinically acceptable range. Conclusion: The most accurate combination is multimix technique with spacer design which uses less bulk of impression material. PMID:25177635

  8. Additive manufacturing and mechanical characterization of graded porosity scaffolds designed based on triply periodic minimal surface architectures.

    PubMed

    Afshar, M; Anaraki, A Pourkamali; Montazerian, H; Kadkhodapour, J

    2016-09-01

    Since the advent of additive manufacturing techniques, triply periodic minimal surfaces have emerged as a novel tool for designing porous scaffolds. Whereas scaffolds are expected to provide multifunctional performance, spatially changing pore patterns have been a promising approach to integrate mechanical characteristics of different architectures into a unique scaffold. Smooth morphological variations are also frequently seen in nature particularly in bone and cartilage structures and can be inspiring for designing of artificial tissues. In this study, we carried out experimental and numerical procedures to uncover the mechanical properties and deformation mechanisms of linearly graded porosity scaffolds for two different mathematically defined pore structures. Among TPMS-based scaffolds, P and D surfaces were subjected to gradient modeling to explore the mechanical responses for stretching and bending dominated deformations, respectively. Moreover, the results were compared to their corresponding uniform porosity structures. Mechanical properties were found to be by far greater for the stretching dominated structure (P-Surface). For bending dominated architecture (D-Surface), although there was no global fracture for uniform structures, graded structure showed a brittle fracture at 0.08 strain. A layer by layer deformation mechanism for stretching dominated structure was observed. For bending dominated scaffolds, deformation was accompanied by development of 45° shearing bands. Finite element simulations were also performed and the results showed a good agreement with the experimental observations.

  9. Integrated Autopilot/Autothrottle Based on a Total Energy Control Concept: Design and Evaluation of Additional Autopilot Modes

    NASA Technical Reports Server (NTRS)

    Bruce, Kevin R.

    1988-01-01

    An integrated autopilot/autothrottle system was designed using a total energy control design philosophy. This design ensures that the system can differentiate between maneuvers requiring a change in thrust to accomplish a net energy change, and those maneuvers which only require elevator control to redistribute energy. The system design, the development of the system, and a summary of simulation results are defined.

  10. Additive effects on the improvement of insecticidal activity: Design, synthesis, and insecticidal activity of novel pymetrozine derivatives.

    PubMed

    Yang, Yan; Liu, Yuxiu; Song, Hongjian; Li, Yongqiang; Wang, Qingmin

    2016-02-01

    A series of new pymetrozine analogues containing both methyl on the imine carbon and phenoxy group at the pyridine ring were designed and synthesized. Their insecticidal activities against bean aphid (Aphis craccivora), mosquito larvae (Culex pipiens pallens), cotton bollworm (Helicoverpa armigera), corn borer (Ostrinia nubilalis) and oriental armyworm (Mythimna separata) were evaluated. The results of bioassays indicated that most of the target compounds showed good insecticidal activity against bean aphid; especially, IIIf (80%) and IIIl (80%) exhibited higher aphicidal activity than pymetrozine (30%) at 5mg/kg, and the two compounds still showed 20% and 30% mortality at 2.5mg/kg, respectively, whereas pymetrozine displayed no activity at the same concentration. These compounds exhibited a completely different structure-activity relationship to that of known pymetrozine derivatives, in which it is thought introducing alkyl group on the imine carbon could be detrimental to the activities. Our new result suggested that the methyl on the imine carbon and phenoxy group at the pyridine ring of phenoxy group may play additive effects on the improvement of aphicidal activity. Besides this, compound IIIs, containing an allyl at the para position of phenoxy group, exhibited excellent insecticidal activity against mosquito larvae, lepidoptera pests cotton bollworm, corn borer and oriental armyworm.

  11. Toxicological features of maleilated polyflavonoids from Pinus radiata (D. Don.) as potential functional additives for biomaterials design.

    PubMed

    García, Danny E; Medina, Paulina A; Zúñiga, Valentina I

    2017-03-14

    Polyflavonoids from Pinus radiata (D. Don.) are an abundant natural oligomers highly desirable as renewable chemicals. However, structural modification of polyflavonoids is a viable strategy in order to use such polyphenols as macrobuilding-blocks for biomaterial design. Polyflavonoids were esterified with three five-member cyclic anhydrides (maleic, itaconic, and citraconic) at 20 °C during 24 h in order to diversify physicochemical-, and biological-properties for agricultural, and food-packaging applications. In addition, the influence of the chemical modification, as well as the chemical structure of the grafting on toxicological features was evaluated. Structural features of derivatives were analyzed by spectroscopy (FT-IR and (1)H-NMR), and the degree of substitution was calculated. Toxicological profile was assessed by using three target species in a wide range of concentration (0.01-100 mgL(-)(1)). Effect of polyflavonoids on the growth rate (Selenastrum capricornutum), mortality (Daphnia magna), and germination and radicle length (Lactuca sativa) was determined. Chemical modification affects the toxicological profile on the derivatives in a high extent. Results described remarkable differences in function of the target specie. The bioassays indicate differences of the polyflavonoids toxicological profile associated to the chemical structure of the grafting. Results allowed conclude that polyflavonoids from pine bark show slight toxic properties.

  12. D-OPTIMAL EXPERIMENTAL DESIGNS TO TEST FOR DEPARTURE FROM ADDITIVITY IN A FIXED-RATIO MIXTURE RAY.

    EPA Science Inventory

    Traditional factorial designs for evaluating interactions among chemicals in a mixture are prohibitive when the number of chemicals is large. However, recent advances in statistically-based experimental design have made it easier to evaluate interactions involving many chemicals...

  13. 40 CFR 267.1103 - What additional design and operating standards apply if liquids will be in my containment building?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the migration of hazardous constituents into the barrier (for example, a geomembrane covered by a... containment system, including a secondary barrier designed and constructed to prevent migration of...

  14. 40 CFR 267.1103 - What additional design and operating standards apply if liquids will be in my containment building?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the migration of hazardous constituents into the barrier (for example, a geomembrane covered by a... containment system, including a secondary barrier designed and constructed to prevent migration of...

  15. 40 CFR 267.1103 - What additional design and operating standards apply if liquids will be in my containment building?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the migration of hazardous constituents into the barrier (for example, a geomembrane covered by a... containment system, including a secondary barrier designed and constructed to prevent migration of...

  16. 77 FR 60437 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ... Compensation Analysis and Support, NIOSH, 4676 Columbia Parkway, MS C- ] 46, Cincinnati, OH 45226, Telephone... for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following class of employees as an... designation became effective on September 22, 2012, as provided for under 42 U.S.C. 7384l(14)(C)....

  17. 75 FR 27784 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... [Federal Register Volume 75, Number 95 (Tuesday, May 18, 2010)] [Notices] [Page 27784] [FR Doc No: 2010-11881] DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees... concerning the final effect of the decision to designate a class of employees from Lawrence...

  18. 75 FR 27785 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... [Federal Register Volume 75, Number 95 (Tuesday, May 18, 2010)] [Notices] [Page 27785] [FR Doc No: 2010-11878] DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees... concerning the final effect of the decision to designate a class of employees from Area IV of the...

  19. 75 FR 27784 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... [Federal Register Volume 75, Number 95 (Tuesday, May 18, 2010)] [Notices] [Page 27784] [FR Doc No: 2010-11880] DEPARTMENT OF HEALTH AND HUMAN SERVICES Final Effect of Designation of a Class of Employees... concerning the final effect of the decision to designate a class of employees from the Nevada Test Site as...

  20. Performance of portland limestone cements: Cements designed to be more sustainable that include up to 15% limestone addition

    NASA Astrophysics Data System (ADS)

    Barrett, Timothy J.

    In 2009, ASTM and AASHTO permitted the use of up to 5% interground limestone in ordinary portland cement (OPC) as a part of a change to ASTM C150/AASHTO M85. When this work was initiated a new proposal was being discussed that would enable up to 15% interground limestone cement to be considered in ASTM C595/AASHTO M234. This work served to provide rapid feedback to the state department of transportation and concrete industry for use in discussions regarding these specifications. Since the time this work was initiated, ASTM C595/AASHTO M234 was passed (2012c) and PLCs are now able to be specified, however they are still not widely used. The proposal for increasing the volume of limestone that would be permitted to be interground in cement is designed to enable more sustainable construction, which may significantly reduce the CO2 that is embodied in the built infrastructure while also extending the life of cement quarries. Research regarding the performance of cements with interground limestone has been conducted by the cement industry since these cements became widely used in Europe over three decades ago, however this work focuses on North American Portland Limestone Cements (PLCs) which are specifically designed to achieve similar performance as the OPCs they replace.This thesis presents a two-phase study in which the potential for application of cements containing limestone was assessed. The first phase of this study utilized a fundamental approach to determine whether cement with up to 15% of interground or blended limestone can be used as a direct substitute to ordinary portland cement. The second phase of the study assessed the concern of early age shrinkage and cracking potential when using PLCs, as these cements are typically ground finer than their OPC counterparts. For the first phase of the study, three commercially produced PLCs were obtained and compared to three commercially produced OPCs made from the same clinker. An additional cement was tested

  1. 76 FR 33762 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... decision to designate a class of employees from the Linde Ceramics Plant in Tonawanda, New York, as an... worked at the Linde Ceramics Plant in Tonawanda, New York, from January 1, 1954 through December 31,...

  2. 76 FR 72929 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Ames Laboratory at Iowa State University during the period from August 13, 1942 through December 31... decision to designate a class of employees from the Ames Laboratory at Iowa State University, as...

  3. 75 FR 51816 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... HHS decision to designate a class of employees from the Mound Plant in Miamisburg, Ohio, as an... tritium bioassay sample and worked at the Mound Plant in Miamisburg, Ohio from March 1, 1959 through...

  4. 78 FR 3898 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... notice concerning the final effect of the HHS decision to designate a class of employees from the Mound... contractors and subcontractors who worked at the Mound Plant in Miamisburg, Ohio, from September 1,...

  5. D-OPTIMAL EXPERIMENTAL DESIGNS TO TEST FOR DEPARTURE FROM ADDITIVITY IN A FIXED-RATIO RAY MIXTURE.

    EPA Science Inventory

    Risk assessors are becoming increasingly aware of the importance of assessing interactions between chemicals in a mixture. Most traditional designs for evaluating interactions are prohibitive when the number of chemicals in the mixture is large. However, evaluation of interacti...

  6. 76 FR 72928 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... decision to designate a class of employees from W.R. Grace and Company in Curtis Bay, Maryland, as an... worked at any building or area at the facility owned by W.R. Grace and Company in Curtis Bay,...

  7. 75 FR 27784 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... concerning the final effect of the decision to designate a class of employees from Westinghouse Electric Corp... Atomic Weapons Employer employees who worked at Westinghouse Electric Corp., Bloomfield, New Jersey,...

  8. Recommendations for Additional Design Development of Components for the SpinTek Rotary Microfilter Prior to Radioactive Service

    SciTech Connect

    Herman, D.T.

    2004-02-13

    The SpinTek rotary microfilter is being considered as an alternative to crossflow filtration. Prior testing evaluated the vendor's standard design for a 1-disk and 3-disk design. We noted several areas of improvement during the testing of the two filter systems that can be included in the 25-disk plant size unit.This report outlines several potential enhancements and improvements to the vendor's standard design which would extend the lifetime of the unit and increase the ability to perform maintenance for units deployed in radioactive service. The enhancements proposed in this report can be implemented to the current design with minimal impact to the cost and schedule of the purchase of the standard unit. An example of this is the replacement of the current mechanical seal with a bellows seal. The improvements proposed will require an extensive redesign of components found in the current system such as the filter chamber.

  9. 77 FR 15759 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... Ceramics Plant in Tonawanda, New York, as an addition to the Special Exposure Cohort (SEC) under the Energy... to the SEC: All Atomic Weapons Employees who worked in any area at the Linde Ceramics Plant...

  10. 77 FR 60438 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ... Winchester Engineering and Analytical Center Site, in Winchester, Massachusetts, as an addition to the... Analytical Center in Winchester, Massachusetts, from January 1, 1952, through December 31, 1961, for a...

  11. 77 FR 60437 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ... Clarksville Modification Center Site, Ft. Campbell, in Clarksville, Tennessee, as an addition to the Special.... Campbell, in Clarksville, Tennessee, from August 1, 1949, through December 31, 1967, for a number of...

  12. 77 FR 15759 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... Savannah River Site in Aiken, South Carolina, as an addition to the Special Exposure Cohort (SEC) under the... contractors and subcontractors who worked at the Savannah River Site from January 1, 1953, through...

  13. 77 FR 38834 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Engineer Works in Oak Ridge, Tennessee, as an addition to the Special Exposure Cohort (SEC) under the... Carbon Chemicals Corporation (1947-1949) who were employed at the Clinton Engineer Works in Oak...

  14. 77 FR 42500 - Designation of a Class of Employees for Addition to the Special Exposure Cohort; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... give notice of a decision to designate a class of employees from the Feed Materials Production Center (FMPC) in Fernald, Ohio, also known as the Fernald Environmental Management Project (FEMP), as an... worked at the Feed Materials Production Center (FMPC) in Fernald, Ohio, from January 1, 1968...

  15. 78 FR 21954 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ..., 2013, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following class of..., 2013, as provided for under 42 U.S.C. 7384l(14)(C). Hence, beginning on April 5, 2013, members of this... INFORMATION CONTACT: Stuart L. Hinnefeld, Director, Division of Compensation Analysis and Support, NIOSH,...

  16. 78 FR 21954 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... provided for under 42 U.S.C. Sec. 7384q(b), the Secretary of HHS designated the following class of..., 2013, as provided for under 42 U.S.C. 7384l(14)(C). Hence, beginning on April 5, 2013, members of this... INFORMATION CONTACT: Stuart L. Hinnefeld, Director, Division of Compensation Analysis and Support, NIOSH,...

  17. 77 FR 46438 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ..., National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS C-46, Cincinnati... under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following class of employees as an... effective on July 27, 2012, as provided for under 42 U.S.C. 7384l(14)(C). Hence, beginning on July 27,...

  18. 40 CFR 267.1103 - What additional design and operating standards apply if liquids will be in my containment building?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... appropriate means, you must include: (a) A primary barrier designed and constructed of materials to prevent...) Constructed of a granular drainage material with a hydraulic conductivity of 1 × 10− 2 cm/sec or more and a thickness of 12 inches (30.5 cm) or more, or constructed of synthetic or geonet drainage materials with...

  19. 76 FR 6056 - Additional Air Quality Designations for the 2006 24-Hour Fine Particle National Ambient Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... Order Reviews A. Executive Order 12866: Regulatory Planning and Review B. Paperwork Reduction Act C... and is subject to CAA section 107(d)(2)(B), which does not require that the Agency issue a notice of.../attainment,'' while a portion of Pinal County is being designated as ``nonattainment.'' This action...

  20. 78 FR 3897 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... and Prevention, Department of Health and Human Services (HHS). ACTION: Notice. SUMMARY: HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Nuclear... Nuclear Metals, Inc. (or a subsequent owner) in West Concord, Massachusetts, during the period...

  1. Recent Additions in the Modeling Capabilities of an Open-Source Wave Energy Converter Design Tool: Preprint

    SciTech Connect

    Tom, N.; Lawson, M.; Yu, Y. H.

    2015-04-20

    WEC-Sim is a midfidelity numerical tool for modeling wave energy conversion devices. The code uses the MATLAB SimMechanics package to solve multibody dynamics and models wave interactions using hydrodynamic coefficients derived from frequency-domain boundary-element methods. This paper presents the new modeling features introduced in the latest release of WEC-Sim. The first feature discussed conversion of the fluid memory kernel to a state-space form. This enhancement offers a substantial computational benefit after the hydrodynamic body-to-body coefficients are introduced and the number of interactions increases exponentially with each additional body. Additional features include the ability to calculate the wave-excitation forces based on the instantaneous incident wave angle, allowing the device to weathervane, as well as import a user-defined wave elevation time series. A review of the hydrodynamic theory for each feature is provided and the successful implementation is verified using test cases.

  2. Analytical curve or standard addition method: how to elect and design--a strategy applied to copper determination in sugarcane spirits using AAS.

    PubMed

    Honorato, Fernanda Araujo; Honorato, Ricardo Saldanha; Pimentel, Maria Fernanda; Araujo, Mario Cesar Ugulino

    2002-11-01

    In most instrumental analysis, the analyte concentration is usually obtained the by Analytical Curve Method (ACM) or Standard Addition Method (SAM). Thus, it is important for the analyst to select the most appropriate method, to seek the best conditions of analysis, and to provide parameters of analytical performance. A strategy to do so is proposed in this paper in conjunction with MATLAB software to implement it. The proposed strategy was applied to copper determination by atomic absorption spectrometry in Brazilian sugarcane spirits termed 'Cachaça' and SAM was chosen as the most appropriate method. To select the best experimental design for SAM, the influence of some factors, such as the number of standard additions and concentration levels, the location of the levels and the average concentration of the standard additions were demonstrated. The design with six standard additions, four concentration levels located near the inferior and superior levels and the average concentration of the standard additions closer to zero yielded SAM with an adequate compromise between precision, cost and time of analysis. The uniform distribution of concentration levels, usually used in routine analysis, is not a good design regarding precision. On the other hand, it is adequate when the linear range is unknown. Generally, the proposed strategy can be applied to different instrumental techniques and samples, which aim to improve their analytical performance.

  3. Viscosity modification of high-oleic sunflower oil with polymeric additives for the design of new biolubricant formulations.

    PubMed

    Quinchia, L A; Delgado, M A; Valencia, C; Franco, J M; Gallegos, C

    2009-03-15

    Although most common lubricants contain mineral or synthetic oils as basestocks, new environmental regulations are demanding environmentally friendly lubricants. In this sense, vegetable oils represent promising alternatives to mineral-based lubricants because of their high biodegradability, good lubricity, and low volatility. However, their poor thermooxidative stability and the small range of viscosity represent a clear disadvantage to be used as suitable biolubricants. The main objective of this work was to develop new environmentally friendly lubricant formulations with improved kinematic viscosity values and viscosity thermal susceptibility. With this aim, a high-oleic sunflower oil (HOSO) was blended with polymeric additives, such as ethylene vinyl acetate (EVA) and styrene-butadiene-styrene (SBS) copolymers, at different concentrations (0.5-5% w/w). Dynamic viscosity and density measurements were performed in a rotational rheometer and capillary densimeter, respectively, in a temperature range between 25 and 120 degrees C. An Arrhenius-like equation fits the evolution of viscosity with temperature fairly well. Both EVA and SBS copolymers may be satisfactorily used as additives to increase the viscosity of HOSO, thus improving the low viscosity values of this oil. HOSO viscosity increases with polymer concentration. Specifically, EVA/HOSO blends exhibit higher viscosity values, which are needed for applications such as lubrication of bearings and four-stroke engines. On the other hand, viscositythermal susceptibility of HOSO samples increases with EVA or SBS concentration.

  4. Designating Additions to the Current List of Tropical Diseases in the Federal Food, Drug, and Cosmetic Act. Final order.

    PubMed

    2015-08-20

    The Federal Food, Drug, and Cosmetic Act (the FD&C Act) authorizes the Food and Drug Administration (FDA or Agency) to award priority review vouchers (PRVs) to tropical disease product applicants when the applications meet certain criteria. The FD&C Act lists the diseases that are considered to be tropical diseases for purposes of obtaining PRVs, and also provides for Agency expansion of that list to include other diseases that satisfy the definition of ``tropical diseases'' as set forth in the FD&C Act. FDA has determined that Chagas disease and neurocysticercosis satisfy this definition, and therefore is adding them to the list of designated tropical diseases whose product applications may result in the award of PRVs. Sponsors submitting certain applications for the treatment of Chagas disease and neurocysticercosis may be eligible to receive a PRV if such applications are approved by FDA.

  5. Design and Application of Wuhan Ionospheric Oblique Backscattering Sounding System with the Addition of an Antenna Array (WIOBSS-AA)

    PubMed Central

    Cui, Xiao; Chen, Gang; Wang, Jin; Song, Huan; Gong, Wanlin

    2016-01-01

    The Wuhan Ionospheric Oblique Backscattering Sounding System with the addition of an antenna array (WIOBSS-AA) is the newest member of the WIOBSS family. It is a multi-channel radio system using phased-array antenna technology. The transmitting part of this radio system applies an array composed of five log-periodic antennas to form five beams that span an area to the northwest of the radar site. The hardware and the antenna array of the first multi-channel ionosonde in the WIOBSS family are introduced in detail in this paper. An ionospheric detection experiment was carried out in Chongyang, Hubei province, China on 16 March 2015 to examine the performance of WIOBSS-AA. The radio system demonstrated its ability to obtain ionospheric electron density information over a wide area. The observations indicate that during the experiment, the monitored large-area ionospheric F2-layer was calm and electron density increased with decreasing latitude. PMID:27314360

  6. Design and Application of Wuhan Ionospheric Oblique Backscattering Sounding System with the Addition of an Antenna Array (WIOBSS-AA).

    PubMed

    Cui, Xiao; Chen, Gang; Wang, Jin; Song, Huan; Gong, Wanlin

    2016-06-15

    The Wuhan Ionospheric Oblique Backscattering Sounding System with the addition of an antenna array (WIOBSS-AA) is the newest member of the WIOBSS family. It is a multi-channel radio system using phased-array antenna technology. The transmitting part of this radio system applies an array composed of five log-periodic antennas to form five beams that span an area to the northwest of the radar site. The hardware and the antenna array of the first multi-channel ionosonde in the WIOBSS family are introduced in detail in this paper. An ionospheric detection experiment was carried out in Chongyang, Hubei province, China on 16 March 2015 to examine the performance of WIOBSS-AA. The radio system demonstrated its ability to obtain ionospheric electron density information over a wide area. The observations indicate that during the experiment, the monitored large-area ionospheric F2-layer was calm and electron density increased with decreasing latitude.

  7. Design of Selective Gas Sensors Using Additive-Loaded In2O3 Hollow Spheres Prepared by Combinatorial Hydrothermal Reactions

    PubMed Central

    Kim, Sun-Jung; Hwang, In-Sung; Kang, Yun Chan; Lee, Jong-Heun

    2011-01-01

    A combinatorial hydrothermal reaction has been used to prepare pure and additive (Sb, Cu, Nb, Pd, and Ni)-loaded In2O3 hollow spheres for gas sensor applications. The operation of Pd- and Cu-loaded In2O3 sensors at 371 °C leads to selective H2S detection. Selective detection of CO and NH3 was achieved by the Ni-In2O3 sensor at sensing temperatures of 371 and 440 °C, respectively. The gas responses of six different sensors to NH3, H2S, H2, CO and CH4 produced unique gas sensing patterns that can be used for the artificial recognition of these gases. PMID:22346661

  8. Measurement of water by oven evaporation using a novel oven design. 2. Water in motor oils and motor oil additives.

    PubMed

    Margolis, Sam A; Vaishnav, Kevin; Sieber, John R

    2004-11-01

    The measurement of water in lubricating oils is important because water accelerates the corrosion of metal parts and bearings in motors. Some of the additives added to lubricating oils to improve their performance react with the Karl Fischer reagent (KFR) causing a positive bias in the water measurement. A new oven evaporation technique for measuring water in oils has been developed that is automated, requires less sample handling, is easily calibrated, and is capable of measuring relatively small mass fractions of water (> or =50 mg/kg sample). A series of motor oils was analyzed with the standard KFR, a reagent that detects interfering substances that reduce iodine, and the aldehyde-ketone reagent that does not detect substances that react with methanol and form water. The oil samples were heated to 107 degrees C and then reheated to 160 degrees C. At both temperatures, material was measured by both KFRs, but only zinc dithiophosphate released sulfur compounds that would react with the reagent that detects interfering substances. Mass fractions of between 20 and 70% of the volatile material released at either temperature were measured with the standard KFR but not with the aldehyde-ketone reagent. These results demonstrate that there are a number of sources of positive bias in the measurement of water in motor oils and that the standard KFR cannot be used to measure water in motor oils and motor oil additives. These results also indicate that some of the material reacts with methanol to form water. Finally, these results suggest that some of the material that is volatile at 160 degrees C and not at 107 degrees C may be water that is physically occluded or may be substances that react with diethyleneglycol monomethylether to produce water.

  9. Tandem Solar Cells Using GaAs Nanowires on Si: Design, Fabrication, and Observation of Voltage Addition.

    PubMed

    Yao, Maoqing; Cong, Sen; Arab, Shermin; Huang, Ningfeng; Povinelli, Michelle L; Cronin, Stephen B; Dapkus, P Daniel; Zhou, Chongwu

    2015-11-11

    Multijunction solar cells provide us a viable approach to achieve efficiencies higher than the Shockley-Queisser limit. Due to their unique optical, electrical, and crystallographic features, semiconductor nanowires are good candidates to achieve monolithic integration of solar cell materials that are not lattice-matched. Here, we report the first realization of nanowire-on-Si tandem cells with the observation of voltage addition of the GaAs nanowire top cell and the Si bottom cell with an open circuit voltage of 0.956 V and an efficiency of 11.4%. Our simulation showed that the current-matching condition plays an important role in the overall efficiency. Furthermore, we characterized GaAs nanowire arrays grown on lattice-mismatched Si substrates and estimated the carrier density using photoluminescence. A low-resistance connecting junction was obtained using n(+)-GaAs/p(+)-Si heterojunction. Finally, we demonstrated tandem solar cells based on top GaAs nanowire array solar cells grown on bottom planar Si solar cells. The reported nanowire-on-Si tandem cell opens up great opportunities for high-efficiency, low-cost multijunction solar cells.

  10. Design and analysis of a piezoelectric material based touch screen with additional pressure and its acceleration measurement functions

    NASA Astrophysics Data System (ADS)

    Chu, Xiang-Cheng; Liu, Jia-Yi; Gao, Ren-Long; Chang, Jie; Li, Long-Tu

    2013-12-01

    Touch screens are becoming more and more prevalent in everyday environments due to their convenience and humanized operation. In this paper, a piezoelectric material based touch screen is developed and investigated. Piezoelectric ceramics arrayed under the touch panel at the edges or corners are used as tactile sensors to measure the touch positioning point similarly to conventional touch screens. However, additional touch pressure and its acceleration performance can also be obtained to obtain a higher-level human-machine interface. The piezoelectric ceramics can also be added to a traditional touch screen structure, or they can be used independently to construct a novel touch screen with a high light transmittance approach to a transparent glass. The piezoelectric ceramics were processed from PZT piezoelectric ceramic powder into a round or rectangular shape. According to the varied touch position and physical press strength of a finger, or even a gloved hand or fingernail, the piezoelectric tactile sensors will have different output voltage responses. By calculating the ratio of different piezoelectric tactile sensors’ responses and summing up all piezoelectric tactile sensors’ output voltages, the touch point position, touch pressure and touch force acceleration can be detected. A prototype of such a touch screen is manufactured and its position accuracy, touch pressure and response speed are measured in detail. The experimental results show that the prototype has many advantages such as high light transmittance, low energy cost and high durability.

  11. Demonstration of the Recent Additions in Modeling Capabilities for the WEC-Sim Wave Energy Converter Design Tool: Preprint

    SciTech Connect

    Tom, N.; Lawson, M.; Yu, Y. H.

    2015-03-01

    WEC-Sim is a mid-fidelity numerical tool for modeling wave energy conversion (WEC) devices. The code uses the MATLAB SimMechanics package to solve the multi-body dynamics and models the wave interactions using hydrodynamic coefficients derived from frequency domain boundary element methods. In this paper, the new modeling features introduced in the latest release of WEC-Sim will be presented. The first feature discussed is the conversion of the fluid memory kernel to a state-space approximation that provides significant gains in computational speed. The benefit of the state-space calculation becomes even greater after the hydrodynamic body-to-body coefficients are introduced as the number of interactions increases exponentially with the number of floating bodies. The final feature discussed is the capability toadd Morison elements to provide additional hydrodynamic damping and inertia. This is generally used as a tuning feature, because performance is highly dependent on the chosen coefficients. In this paper, a review of the hydrodynamic theory for each of the features is provided and successful implementation is verified using test cases.

  12. β-Amino acid catalyzed asymmetric Michael additions: design of organocatalysts with catalytic acid/base dyad inspired by serine proteases.

    PubMed

    Yang, Hui; Wong, Ming Wah

    2011-09-16

    A new type of chiral β-amino acid catalyst has been computationally designed, mimicking the enzyme catalysis of serine proteases. Our catalyst approach is based on the bioinspired catalytic acid/base dyad, namely, a carboxyl and imidazole pair. DFT calculations predict that this designed organocatalyst catalyzes Michael additions of aldehydes to nitroalkenes with excellent enantioselectivities and remarkably high anti diastereoselectivities. The unusual stacked geometry of the enamine intermediate, hydrogen bonding network, and the adoption of an exo transition state are the keys to understand the stereoselectivity.

  13. The Development of Mathematical Prediction Model to Predict Resilient Modulus for Natural Soil Stabilized by Pofa-Opc Additive for the Use in Unpaved Road Design

    NASA Astrophysics Data System (ADS)

    Gamil, Y. M. R.; Bakar, I. H.

    2016-07-01

    Resilient Modulus (Mr) is considered one of the most important parameters in the design of road structure. This paper describes the development of the mathematical model to predict resilient modulus of organic soil stabilized by the mix of Palm Oil Fuel Ash - Ordinary Portland Cement (POFA-OPC) soil stabilization additives. It aims to optimize the use of the use of POFA in soil stabilization. The optimization models enable to eliminate the arbitrary selection and its associated disadvantages in determination of the optimum additive proportion. The model was developed based on Scheffe regression theory. The mix proportions of the samples in the experiment were adopted from similar studies reported in the literature Twenty five samples were designed, prepared and then characterized for each mix proportion based on the MR in 28 days curing. The results are used to develop the mathematical prediction model. The model was statistically analyzed and verified for its adequacy and validity using F-test.

  14. Food additives

    PubMed Central

    Spencer, Michael

    1974-01-01

    Food additives are discussed from the food technology point of view. The reasons for their use are summarized: (1) to protect food from chemical and microbiological attack; (2) to even out seasonal supplies; (3) to improve their eating quality; (4) to improve their nutritional value. The various types of food additives are considered, e.g. colours, flavours, emulsifiers, bread and flour additives, preservatives, and nutritional additives. The paper concludes with consideration of those circumstances in which the use of additives is (a) justified and (b) unjustified. PMID:4467857

  15. Fuel characteristics pertinent to the design of aircraft fuel systems, Supplement I : additional information on MIL-F-7914(AER) grade JP-5 fuel and several fuel oils

    NASA Technical Reports Server (NTRS)

    Barnett, Henry C; Hibbard, Robert R

    1953-01-01

    Since the release of the first NACA publication on fuel characteristics pertinent to the design of aircraft fuel systems (NACA-RM-E53A21), additional information has become available on MIL-F7914(AER) grade JP-5 fuel and several of the current grades of fuel oils. In order to make this information available to fuel-system designers as quickly as possible, the present report has been prepared as a supplement to NACA-RM-E53A21. Although JP-5 fuel is of greater interest in current fuel-system problems than the fuel oils, the available data are not as extensive. It is believed, however, that the limited data on JP-5 are sufficient to indicate the variations in stocks that the designer must consider under a given fuel specification. The methods used in the preparation and extrapolation of data presented in the tables and figures of this supplement are the same as those used in NACA-RM-E53A21.

  16. Food additives

    MedlinePlus

    ... or natural. Natural food additives include: Herbs or spices to add flavor to foods Vinegar for pickling ... Certain colors improve the appearance of foods. Many spices, as well as natural and man-made flavors, ...

  17. Potlining Additives

    SciTech Connect

    Rudolf Keller

    2004-08-10

    In this project, a concept to improve the performance of aluminum production cells by introducing potlining additives was examined and tested. Boron oxide was added to cathode blocks, and titanium was dissolved in the metal pool; this resulted in the formation of titanium diboride and caused the molten aluminum to wet the carbonaceous cathode surface. Such wetting reportedly leads to operational improvements and extended cell life. In addition, boron oxide suppresses cyanide formation. This final report presents and discusses the results of this project. Substantial economic benefits for the practical implementation of the technology are projected, especially for modern cells with graphitized blocks. For example, with an energy savings of about 5% and an increase in pot life from 1500 to 2500 days, a cost savings of $ 0.023 per pound of aluminum produced is projected for a 200 kA pot.

  18. Phosphazene additives

    DOEpatents

    Harrup, Mason K; Rollins, Harry W

    2013-11-26

    An additive comprising a phosphazene compound that has at least two reactive functional groups and at least one capping functional group bonded to phosphorus atoms of the phosphazene compound. One of the at least two reactive functional groups is configured to react with cellulose and the other of the at least two reactive functional groups is configured to react with a resin, such as an amine resin of a polycarboxylic acid resin. The at least one capping functional group is selected from the group consisting of a short chain ether group, an alkoxy group, or an aryloxy group. Also disclosed are an additive-resin admixture, a method of treating a wood product, and a wood product.

  19. Community-Based Health Education Programs Designed to Improve Clinical Measures Are Unlikely to Reduce Short-Term Costs or Utilization Without Additional Features Targeting These Outcomes.

    PubMed

    Burton, Joe; Eggleston, Barry; Brenner, Jeffrey; Truchil, Aaron; Zulkiewicz, Brittany A; Lewis, Megan A

    2016-06-07

    Stakeholders often expect programs for persons with chronic conditions to "bend the cost curve." This study assessed whether a diabetes self-management education (DSME) program offered as part of a multicomponent initiative could affect emergency department (ED) visits, hospital stays, and the associated costs for an underserved population in addition to the clinical indicators that DSME programs attempt to improve. The program was implemented in Camden, New Jersey, by the Camden Coalition of Healthcare Providers to address disparities in diabetes care. Data used are from medical records and from patient-level information about hospital services from Camden's hospitals. Using multivariate regression models to control for individual characteristics, changes in utilization over time and changes relative to 2 comparison groups were assessed. No reductions in ED visits, inpatient stays, or costs for participants were found over time or relative to the comparison groups. High utilization rates and costs for diabetes are associated with longer term disease progression and its sequelae; thus, DSME or peer support may not affect these in the near term. Some clinical indicators improved among participants, and these might lead to fewer costly adverse health events in the future. DSME deployed at the community level, without explicit segmentation and targeting of high health care utilizers or without components designed to affect costs and utilization, should not be expected to reduce short-term medical needs for participating individuals or care-seeking behaviors such that utilization is reduced. Stakeholders must include financial outcomes in a program's design if those outcomes are to improve. (Population Health Management 20XX;XX:XXX-XXX).

  20. Design of phosphonium-type zwitterion as an additive to improve saturated water content of phase-separated ionic liquid from aqueous phase toward reversible extraction of proteins.

    PubMed

    Ito, Yoritsugu; Kohno, Yuki; Nakamura, Nobuhumi; Ohno, Hiroyuki

    2013-09-05

    We designed phosphonium-type zwitterion (ZI) to control the saturated water content of separated ionic liquid (IL) phase in the hydrophobic IL/water biphasic systems. The saturated water content of separated IL phase, 1-butyl-3-methyimidazolium bis(trifluoromethanesulfonyl)imide, was considerably improved from 0.4 wt% to 62.8 wt% by adding N,N,N-tripentyl-4-sulfonyl-1-butanephosphonium-type ZI (P555C4S). In addition, the maximum water content decreased from 62.8 wt% to 34.1 wt% by increasing KH2PO4/K2HPO4 salt content in upper aqueous phosphate buffer phase. Horse heart cytochrome c (cyt.c) was dissolved selectively in IL phase by improving the water content of IL phase, and spectroscopic analysis revealed that the dissolved cyt.c retained its higher ordered structure. Furthermore, cyt. c dissolved in IL phase was re-extracted again from IL phase to aqueous phase by increasing the concentration of inorganic salts of the buffer solution.

  1. Solving the Big Data (BD) Problem in Advanced Manufacturing (Subcategory for work done at Georgia Tech. Study Process and Design Factors for Additive Manufacturing Improvement)

    SciTech Connect

    Clark, Brett W.; Diaz, Kimberly A.; Ochiobi, Chinaza Darlene; Paynabar, Kamran

    2015-09-01

    3D printing originally known as additive manufacturing is a process of making 3 dimensional solid objects from a CAD file. This ground breaking technology is widely used for industrial and biomedical purposes such as building objects, tools, body parts and cosmetics. An important benefit of 3D printing is the cost reduction and manufacturing flexibility; complex parts are built at the fraction of the price. However, layer by layer printing of complex shapes adds error due to the surface roughness. Any such error results in poor quality products with inaccurate dimensions. The main purpose of this research is to measure the amount of printing errors for parts with different geometric shapes and to analyze them for finding optimal printing settings to minimize the error. We use a Design of Experiments framework, and focus on studying parts with cone and ellipsoid shapes. We found that the orientation and the shape of geometric shapes have significant effect on the printing error. From our analysis, we also determined the optimal orientation that gives the least printing error.

  2. Evaluation of the methylene blue addition in binary polymeric systems composed by poloxamer 407 and Carbopol 934P using quality by design: rheological, textural, and mucoadhesive analysis.

    PubMed

    Junqueira, Mariana Volpato; Borghi-Pangoni, Fernanda Belincanta; Ferreira, Sabrina Barbosa de Souza; Bruschi, Marcos Luciano

    2016-12-01

    This study describes the investigation about the physicochemical behavior of methylene blue (Mb) addition to systems containing poloxamer 407 (Polox), Carbopol 934P (Carb), intended to be locally used by photodynamic therapy. A factorial design 2(3) (plus center point) was used to analyze the rheological, mucoadhesive and textural properties of the preparations. Systems containing the lower concentrations of Polox (15 and 17.5%, w/w) exhibited pseudoplastic flow and low degrees of rheopexy. On the other hand, at higher Polox concentration (20%, w/w) the systems display plastic flow and thixotropy. Carb and Mb exhibited a negative influence for the consistency and flow behavior index, due to the interaction between them. For most of the formulations, the increase of Polox and Mb content significantly increased storage modulus, loss modulus and dynamic viscosity. The systems display a sol-gel transition temperature, existing as a liquid at room temperature and gel at 29-37 °C. Increasing the temperature and the polymer concentration, the compressional properties of systems significantly increased. The mucoadhesion was noted to all formulations, except to systems composed by 15% (w/w) of Polox. The analyses enabled to understand and predict the performance of formulations and the polymer-Mb interactions, tailoring to the suit systems (Polox/Carb/Mb): 17.5/0.50/0.20 and 20/0.15/0.25.

  3. Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

    PubMed Central

    2013-01-01

    Background Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached. The aim of this study is to investigate the effect attributable to exercise on postmenopausal breast cancer risk biomarkers, when equivalent weight loss is achieved compared with diet-induced weight loss. Design The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25–35 kg/m2) are enrolled. After a 4-6 week run-in period, wherein a baseline diet is prescribed, women are randomly allocated to (1) a diet group, (2) an exercise group or (3) a control group. The aim of both intervention groups is to lose an amount of 5–6 kg body weight in 10–14 weeks. The diet group follows an energy restricted diet and maintains the habitual physical activity level. The exercise group participates in a 16-week endurance and strength training programme of 4 hours per week. Furthermore, they are prescribed a moderate caloric restriction. The control group is asked to maintain body weight and continue the run-in baseline diet. Measurements include blood sampling, questionnaires, anthropometrics (weight, height, waist and hip circumference), maximal cycle exercise test (VO2peak), DEXA-scan (body composition) and abdominal MRI (subcutaneous and visceral fat). Primary outcomes are serum levels of oestradiol, oestrone, testosterone and sex hormone binding globulin (SHBG). Discussion This study will give insight in the potential attributable effect of physical activity on breast cancer risk biomarkers and whether this effect is mediated by changes in body composition, in postmenopausal

  4. Study Design and Percent Recoveries of Anthropogenic Organic Compounds With and Without the Addition of Ascorbic Acid to Preserve Water Samples Containing Free Chlorine, 2004-06

    USGS Publications Warehouse

    Valder, Joshua F.; Delzer, Gregory C.; Price, Curtis V.; Sandstrom, Mark W.

    2008-01-01

    The National Water-Quality Assessment (NAWQA) Program of the U.S. Geological Survey (USGS) began implementing Source Water-Quality Assessments (SWQAs) in 2002 that focus on characterizing the quality of source water and finished water of aquifers and major rivers used by some of the larger community water systems in the United States. As used for SWQA studies, source water is the raw (ambient) water collected at the supply well prior to water treatment (for ground water) or the raw (ambient) water collected from the river near the intake (for surface water). Finished water is the water that is treated, which typically involves, in part, the addition of chlorine or other disinfection chemicals to remove pathogens, and is ready to be delivered to consumers. Finished water is collected before the water enters the distribution system. This report describes the study design and percent recoveries of anthropogenic organic compounds (AOCs) with and without the addition of ascorbic acid to preserve water samples containing free chlorine. The percent recoveries were determined by using analytical results from a laboratory study conducted in 2004 by the USGS's National Water Quality Laboratory (NWQL) and from data collected during 2004-06 for a field study currently (2008) being conducted by the USGS's NAWQA Program. The laboratory study was designed to determine if preserving samples with ascorbic acid (quenching samples) adversely affects analytical performance under controlled conditions. During the laboratory study, eight samples of reagent water were spiked for each of five analytical schedules evaluated. Percent recoveries from these samples were then compared in two ways: (1) four quenched reagent spiked samples analyzed on day 0 were compared with four quenched reagent spiked samples analyzed on day 7 or 14, and (2) the combined eight quenched reagent spiked samples analyzed on day 0, 7, or 14 were compared with eight laboratory reagent spikes (LRSs). Percent

  5. Polylactides in additive biomanufacturing.

    PubMed

    Poh, Patrina S P; Chhaya, Mohit P; Wunner, Felix M; De-Juan-Pardo, Elena M; Schilling, Arndt F; Schantz, Jan-Thorsten; van Griensven, Martijn; Hutmacher, Dietmar W

    2016-12-15

    New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed.

  6. Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines.

    PubMed

    Krenske, Elizabeth H; Petter, Russell C; Houk, K N

    2016-12-02

    Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of several covalent drugs (e.g., afatinib, osimertinib, ibrutinib, neratinib, and CC-292). Reversible Michael acceptors have been reported in which an additional electron-withdrawing group was added at the α-carbon of a Michael acceptor. We have performed density functional theory calculations to determine why thiol additions to these Michael acceptors are reversible. The α-EWG group stabilizes the anionic transition state and intermediate of the Michael addition, but less intuitively, it destabilizes the neutral adduct. This makes the reverse reaction (elimination) both faster and more thermodynamically favorable. For thiol addition to be reversible, the Michael acceptor must also contain a suitable substituent on the β-carbon, such as an aryl or branched alkyl group. Computations explain how these structural elements contribute to reversibility and the ability to tune the binding affinities and the residence times of covalent inhibitors.

  7. Evidence-Based Design for Project-Based Learning: A Case Study for a 50,000 SF Addition Dedicated to the New Tech Curriculum

    ERIC Educational Resources Information Center

    Moretti, Richard D.; Conte, Philip R.

    2012-01-01

    The Seaford School District, Seaford, Delaware, determined that a component of their "reinvention" of Seaford High School would be the creation of a New Tech Academy, affiliated with the New Tech Network and housed in an addition to that building. The New Tech Network, headquartered in Napa, California, is a rapidly growing association…

  8. A Quasi-Experimental Study of Two Selected Units of the Industrial Arts Curriculum Project Materials to Determine the Measurable Additive Effects of a Unit on Design in Manfacturing Technology upon a Similar Unit on Design in Construction Technology.

    ERIC Educational Resources Information Center

    Kuwik, Paul David

    The purpose of the study was to determine whether exposing junior high school students to a unit on design in construction technology and to a unit on design in manufacturing technology significantly affects their achievement on a test measuring "Technological Principles of Design" when compared to a group of junior high school students exposed…

  9. Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines.

    PubMed

    Hooijmans, Carlijn R; de Vries, Rob; Leenaars, Marlies; Curfs, Jo; Ritskes-Hoitinga, Merel

    2011-03-01

    Several studies have demonstrated serious omissions in the way research that use animals is reported. In order to improve the quality of reporting of animal experiments, the Animals in research: reporting in vivo experiments (ARRIVE) Guidelines were published in the British Journal of Pharmacology in August 2010. However, not only the quality of reporting of completed animal studies needs to be improved, but also the design and execution of new experiments. With both these goals in mind, we published the Gold Standard Publication Checklist (GSPC) in May 2010, a few months before the ARRIVE guidelines appeared. In this letter, we compare the GSPC checklist with the ARRIVE Guidelines. The GSPC describes certain items in more detail, which makes it both easier to use when designing and conducting an experiment and particularly suitable for making systematic reviews of animal studies more feasible. In order to improve not only the reporting but also the planning, design, execution and thereby, the scientific quality of animal experiments, we strongly recommend to all scientists involved in animal experimentation and to editors of journals publishing animal studies to take a closer look at the contents of both the ARRIVE guidelines and GSPC, and select the set of guidelines which is most appropriate for their particular situation.

  10. Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase

    PubMed Central

    2015-01-01

    A series of α-ketooxazoles incorporating electrophiles at the C5 position of the pyridyl ring of 2 (OL-135) and related compounds were prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH) that additionally target the cytosolic port Cys269. From this series, a subset of the candidate inhibitors exhibited time-dependent FAAH inhibition and noncompetitive irreversible inactivation of the enzyme, consistent with the targeted Cys269 covalent alkylation or addition, and maintained or enhanced the intrinsic selectivity for FAAH versus other serine hydrolases. A preliminary in vivo assessment demonstrates that these inhibitors raise endogenous brain levels of anandamide and other FAAH substrates upon intraperitoneal (i.p.) administration to mice, with peak levels achieved within 1.5–3 h, and that the elevations of the signaling lipids were maintained >6 h, indicating that the inhibitors effectively reach and remain active in the brain, inhibiting FAAH for a sustained period. PMID:24456116

  11. Additional notes on clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance.

    PubMed

    Takaai, Mari; Kayano, Yuichiro; Shimizu, Takako; Taguchi, Masato; Hashimoto, Yukiya

    2008-01-01

    In the previous study, we performed a simulation of a clinical pharmacokinetic trial, in which blood was sampled at two time points corresponding to the peak concentration (C(peak)) and trough concentration (C(trough)) following repetitive oral administration at the dose, D, and dosing interval, tau. The approximate oral clearance (CL/F(approx)), estimated as 2 x D/(C(peak) x tau+C(trough) x tau), is accurate for drugs with an elimination half-life comparative to or longer than tau; however, it was suggested that we might not use CL/F(approx) for drugs with a considerably short elimination half-life relative to tau. In the present study, we evaluated the accuracy of the alternative oral clearance (CL/F(exp)) estimated by the simple monoexponential model. In contrast to CL/F(approx), CL/F(exp) was accurate for drugs with a short elimination half-life relative to tau. The present finding in conjunction with our previous study suggested that the peak-and-trough sampling design is promising for the clinical repeated-dose pharmacokinetic trial for drugs with not only slow but also rapid elimination from the body. We think that the accuracy and precision of the two analysis methods to estimate oral clearance (CL/F(approx) and CL/F(exp)) for a target drug should be evaluated carefully before and after a real clinical trial.

  12. A Low-Cost Environmental Monitoring System: How to Prevent Systematic Errors in the Design Phase through the Combined Use of Additive Manufacturing and Thermographic Techniques.

    PubMed

    Salamone, Francesco; Danza, Ludovico; Meroni, Italo; Pollastro, Maria Cristina

    2017-04-11

    nEMoS (nano Environmental Monitoring System) is a 3D-printed device built following the Do-It-Yourself (DIY) approach. It can be connected to the web and it can be used to assess indoor environmental quality (IEQ). It is built using some low-cost sensors connected to an Arduino microcontroller board. The device is assembled in a small-sized case and both thermohygrometric sensors used to measure the air temperature and relative humidity, and the globe thermometer used to measure the radiant temperature, can be subject to thermal effects due to overheating of some nearby components. A thermographic analysis was made to rule out this possibility. The paper shows how the pervasive technique of additive manufacturing can be combined with the more traditional thermographic techniques to redesign the case and to verify the accuracy of the optimized system in order to prevent instrumental systematic errors in terms of the difference between experimental and actual values of the above-mentioned environmental parameters.

  13. Design.

    ERIC Educational Resources Information Center

    Online-Offline, 1998

    1998-01-01

    Provides an annotated bibliography of resources on this month's theme "Design" for K-8 language arts, art and architecture, music and dance, science, math, social studies, health, and physical education. Includes Web sites, CD-ROMs and software, videos, books, audiotapes, magazines, professional resources and classroom activities.…

  14. Design

    ERIC Educational Resources Information Center

    Buchanan, Richard; Cross, Nigel; Durling, David; Nelson, Harold; Owen, Charles; Valtonen, Anna; Boling, Elizabeth; Gibbons, Andrew; Visscher-Voerman, Irene

    2013-01-01

    Scholars representing the field of design were asked to identify what they considered to be the most exciting and imaginative work currently being done in their field, as well as how that work might change our understanding. The scholars included Richard Buchanan, Nigel Cross, David Durling, Harold Nelson, Charles Owen, and Anna Valtonen. Scholars…

  15. High-Performance Long-Term-Stable Dopant-Free Perovskite Solar Cells and Additive-Free Organic Solar Cells by Employing Newly Designed Multirole π-Conjugated Polymers.

    PubMed

    Kranthiraja, Kakaraparthi; Gunasekar, Kumarasamy; Kim, Hyunji; Cho, An-Na; Park, Nam-Gyu; Kim, Seonha; Kim, Bumjoon J; Nishikubo, Ryosuke; Saeki, Akinori; Song, Myungkwan; Jin, Sung-Ho

    2017-04-10

    Perovskite solar cells (PSCs) and organic solar cells (OSCs) are promising renewable light-harvesting technologies with high performance, but the utilization of hazardous dopants and high boiling additives is harmful to all forms of life and the environment. Herein, new multirole π-conjugated polymers (P1-P3) are developed via a rational design approach through theoretical hindsight, further successfully subjecting them into dopant-free PSCs as hole-transporting materials and additive-free OSCs as photoactive donors, respectively. Especially, P3-based PSCs and OSCs not only show high power conversion efficiencies of 17.28% and 8.26%, but also display an excellent ambient stability up to 30 d (for PSCs only), owing to their inherent superior optoelectronic properties in their pristine form. Overall, the rational approach promises to support the development of environmentally and economically sustainable PSCs and OSCs.

  16. Perspectives on Additive Manufacturing

    NASA Astrophysics Data System (ADS)

    Bourell, David L.

    2016-07-01

    Additive manufacturing (AM) has skyrocketed in visibility commercially and in the public sector. This article describes the development of this field from early layered manufacturing approaches of photosculpture, topography, and material deposition. Certain precursors to modern AM processes are also briefly described. The growth of the field over the last 30 years is presented. Included is the standard delineation of AM technologies into seven broad categories. The economics of AM part generation is considered, and the impacts of the economics on application sectors are described. On the basis of current trends, the future outlook will include a convergence of AM fabricators, mass-produced AM fabricators, enabling of topology optimization designs, and specialization in the AM legal arena. Long-term developments with huge impact are organ printing and volume-based printing.

  17. Additive manufacturing of optical components

    NASA Astrophysics Data System (ADS)

    Heinrich, Andreas; Rank, Manuel; Maillard, Philippe; Suckow, Anne; Bauckhage, Yannick; Rößler, Patrick; Lang, Johannes; Shariff, Fatin; Pekrul, Sven

    2016-08-01

    The development of additive manufacturing methods has enlarged rapidly in recent years. Thereby, the work mainly focuses on the realization of mechanical components, but the additive manufacturing technology offers a high potential in the field of optics as well. Owing to new design possibilities, completely new solutions are possible. This article briefly reviews and compares the most important additive manufacturing methods for polymer optics. Additionally, it points out the characteristics of additive manufactured polymer optics. Thereby, surface quality is of crucial importance. In order to improve it, appropriate post-processing steps are necessary (e.g. robot polishing or coating), which will be discussed. An essential part of this paper deals with various additive manufactured optical components and their use, especially in optical systems for shape metrology (e.g. borehole sensor, tilt sensor, freeform surface sensor, fisheye lens). The examples should demonstrate the potentials and limitations of optical components produced by additive manufacturing.

  18. Color Addition and Subtraction Apps

    NASA Astrophysics Data System (ADS)

    Ruiz, Frances; Ruiz, Michael J.

    2015-10-01

    Color addition and subtraction apps in HTML5 have been developed for students as an online hands-on experience so that they can more easily master principles introduced through traditional classroom demonstrations. The evolution of the additive RGB color model is traced through the early IBM color adapters so that students can proceed step by step in understanding mathematical representations of RGB color. Finally, color addition and subtraction are presented for the X11 colors from web design to illustrate yet another real-life application of color mixing.

  19. 78 FR 22620 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    .... DE C.V.; a.k.a. SUPERTIENDAS & AUTO PARTES HANDAL), 3 Ave y 14 Calle N.O., Barrio Las Acacias... Las Acacias, Apartado Postal No 1018, San Pedro Sula, Cortes, Honduras . 3. EASY CASH S. DE R.L., San... Copan, Copan, Honduras . 5. JM TROYA, 3 Ave y 14 Calle N.O., Barrio Las Acacias, Apartado Postal No...

  20. 76 FR 6843 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ..., Mexico; 4179 Colonia Miravalle, Guadalajara, Jalisco, Mexico; Sendero Las Acacias 92, Guadalajara..., Esteban; a.k.a. ``VALENCIA, Esteban''), Sendera las Acacias 92, Guadalajara, Jalisco, Mexico; Ricardo... Canario 1, Guadalajara, Jalisco, Mexico; Sendero Las Acacias 92, Guadalajara, Jalisco, Mexico; DOB 14...

  1. 78 FR 61000 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ..., Mexico; 4179 Colonia Miravalle, Guadalajara, Jalisco, Mexico; Sendero Las Acacias 92, Guadalajara... Miravalle, Guadalajara, Jalisco, Mexico; Sendero Las Acacias 92, Guadalajara, Jaslico, Mexico; Vereda...

  2. 78 FR 42589 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... LIMITADA; Linked To: GUBEREK GRIMBERG E HIJOS Y CIA. S. EN C.; Linked To: CONSTRUCTORA NACIONAL DE PANAMA S... TEJIDOS S.A.; Linked To: COMPANIA REAL DE PANAMA S.A.; Linked To: GUBEREK GRIMBERG E HIJOS Y CIA. S. EN C... 1730043 (Colombia); alt. Matricula Mercantil No 1816081 (Colombia) . 12. GUBEREK GRIMBERG E HIJOS Y CIA....

  3. 75 FR 27118 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ...); (INDIVIDUAL) 3. JIMENEZ URREGO, Blanca Virginia, c/o JUAN SEBASTIAN Y CAMILA ANDREA JIMENEZ RAMIREZ Y CIA S.C... INTEGRADOS LTDA, Bogota, Colombia; c/o JUAN SEBASTIAN Y CAMILA ANDREA JIMENEZ RAMIREZ Y CIA S.C.S., Bogota... RAMIREZ Y CIA S.C.S., Bogota, Colombia; DOB 28 Jan 1969; Citizen Colombia; Cedula No. 65552011...

  4. 77 FR 44715 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... VILLABONITA, S.A. DE C.V., Av. Alvaro Obregon No. 6040, Col. Villa Bonita, Culiacan, Sinaloa C.P. 80000, Mexico; R.F.C. GSV-100224-773 (Mexico) . 6. GRUPO CINJAB, S.A. DE C.V. (a.k.a. PROVENZA RESIDENCIAL), Av.... PROVENZA CENTER), Av. Adolfo Lopez Mateos No. 5565, Col. Santa Anita, Tlajomulco de Zuniga, Jalisco...

  5. 78 FR 53191 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    .... DE C.V., Av. Alvaro Obregon No. 6040, Col. Villa Bonita, Culiacan, Sinaloa C.P. 80000, Mexico; R.F.C. GSV-100224-773 (Mexico) . 6. PETROBARRANCOS, S.A. DE C.V., Av. Benjamin Hill No. 5602, Col. Industrial.... DE C.V. (n.k.a. GASOLINERAS LA VILLA, S.A. DE C.V.), Av. Alvaro Obregon No. 6040, Col. Villa...

  6. 78 FR 36635 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... Lomas Altas, Zapopan, Jalisco, Mexico; Av. Pablo Neruda No. 4111, Casa 1, Colonia Lomas del Valle..., Av. Vallarta No. 3060, Colonia Vallarta San Jorge, Guadalajara, Jalisco, Mexico; DOB 03 Mar 1971; POB.... DE C.V.). 10. GARZA RODRIGUEZ, Beatriz (a.k.a. GARZA RODRIGUEZ DE SANCHEZ, Beatriz), Av. Vallarta...

  7. 77 FR 23807 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ..., Col. Roma, Zapopan, Jalisco, Mexico; Blvd. Puerta de Hierro No 6094, Zapopan, Jalisco, Mexico; Paseo...- 583093 (Panama) DISTRIBUIDORA MEDICA HOSPITALARIA, S.A. DE C.V., Colima No. 323 Int. 9, Col. Roma...

  8. 75 FR 10557 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... INVERSIONES BUSTOS ARIZA Y CIA. S.C.S., Bogota, Colombia; c/o MODERNA EXPRESS TRANSPORTE DE CARGA LTDA... LOGISTICA Y TRANSPORTE NORVAL LTDA., Bogota, Colombia; Calle 135 No. 17-25 apto. 503, Bogota, Colombia; DOB... de Oro, Meta, Colombia; Matricula Mercantil No 00118073 (Colombia) . 57. LOGISTICA Y...

  9. 75 FR 15772 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ...; Nationality Mexico; (INDIVIDUAL) 12. FLORES BORREGO, Samuel (a.k.a. ``Samuel FLORES FLORES''); Miguel Aleman... Mexico; (INDIVIDUAL) 15. CANO FLORES, Aurelio (a.k.a. SANCHEZ CASTILLO, Efrain); Miguel Aleman...; Nationality Mexico; C.U.R.P. GACA601113HTSLRN00 (Mexico); (INDIVIDUAL) 46. FLORES SOTO, Mario (a.k.a....

  10. 75 FR 64782 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ...-2 (Colombia); (ENTITY) . Individuals 1. FLORES CACHO, Alejandro (a.k.a. CACHO FLORES, Alejandro; a.k.... MACE590807HDFSMD05 (Mexico); (INDIVIDUAL) . 13. FLORES CACHO, Javier, c/o LA NUMERO UNO DE CUAUHTEMOC S.A. DE...

  11. 78 FR 5562 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... 03040074084 (Mexico) (individual) . 2. FLORES APODACA, Augustin (a.k.a. ``EL BARBON''; a.k.a. ``EL INGENIERO..., Mexico; DOB 09 Jun 1964; POB Sinaloa, Mexico; Passport 040070827 (Mexico) (individual) . 3. FLORES...) . 4. FLORES APODACA, Panfilo; DOB 01 Jun 1969; POB Guasave, Sinaloa, Mexico; Passport...

  12. 75 FR 14255 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... 41, No. 29A-29, Maranilla, Antioquia, Colombia; DOB 23 Apr 1979; POB Colombia; Citizen Colombia... Colombia; (INDIVIDUAL) 11. MANCO TORRES, Jhon Freddy, c/o VIGILAR COLOMBIA LTDA., Apartado, Antioquia...); (INDIVIDUAL) 13. TORO OSORIO, Julio Alberto, c/o RENTA CAMPEROS URABA LTDA., Apartado, Antioquia, Colombia;...

  13. 76 FR 59483 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    .... DOB 13 Apr 1968; POB Medellin, Colombia; alt. POB Marinilla, Antioquia, Colombia; C.U.R.P... MARIN, Fabian Rodrigo, c/o IGA LTDA., Itagui, Antioquia, Colombia; c/o RUTA 33 MOTOCICLETAS Y ACCESORIOS LTDA., Medellin, Colombia; Calle 79A Sur No. 46-53, Sabaneta, Antioquia, Colombia; DOB 25 Aug...

  14. 76 FR 11561 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ..., Mexico; DOB 13 May 1965; alt. DOB 13 Apr 1968; POB Medellin, Colombia; alt. POB Marinilla, Antioquia... COMERCIALIZADORA SYSTOLE S.A.S., Envigado, Antioquia, Colombia; Carrera 41A No. 22 Sur-87, Envigado, Antioquia, Colombia; DOB 4 Nov 1956; POB Yolombo, Antioquia, Colombia; Cedula No. 32524640 (Colombia) (individual)...

  15. 78 FR 66990 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... basis, with the objective of denying their businesses and agents access to the U.S. financial system and... Agricola, Zapopan, Jalisco C.P. 45200, Mexico; R.F.C. SOS050203E31 (Mexico); Folio Mercantil No....

  16. 78 FR 47828 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... denying their businesses and agents access to the U.S. financial system and the benefits of trade and... Rosales, Sinaloa 80430, Mexico; Folio Mercantil No. 75483 (Mexico) . 6. RANCHO AGRICOLA GANADERO...

  17. 77 FR 61051 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... Eliseos No. 403 Interior 202, Colonia Polanco, Delegacion Miguel Hidalgo, Distrito Federal Codigo Postal 11550, Mexico; Calle Moliere No. 66, Colonia Palmas Polanco, Delegacion Miguel Hidalgo, Distrito Federal... Venustiano Carranza, Distrito Federal Codigo Postal 15230, Mexico; Calle Moliere No. 227, Colonia...

  18. 77 FR 71480 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    .... CARDONA MARTINEZ, Mayela (a.k.a. CARDONA DE IBARRA, Mayela), Calle Lago de La Doga 5312, Tijuana, Baja... (Mexico) (individual) . 2. CARDONA MARTINEZ, Pedro, Calle Lago La Doga 5301, Tijuana, Baja...

  19. 75 FR 79440 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ..., Colombia; DOB 17 Sep 1968; Cedula No. 51918595 (Colombia) (individual) 5. GALINDO MARTINEZ, Fernando...; Cedula No. 8281272 (Colombia) (individual) 9. MARTINEZ, Alicia (a.k.a. MARTINEZ GALINDO, Alicia), c/o...

  20. 76 FR 67792 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ..., Mexico; Calle Antonio Caso No. 500, Colonia Aurora, Culiacan, Sinaloa, Mexico; Calle Amapola No. 12... AUTODROMO CULIACAN, Culiacan, Sinaloa, Mexico; Calle Antonio Caso No. 500, Colonia Aurora, Culiacan,...

  1. 75 FR 65554 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    .... financial system and to the benefits of trade and transactions involving U.S. companies and individuals. The... blocked entities is as follows: 1. RUNNING BROOK, LLC (USA), Miami, FL, United States;...

  2. 75 FR 34214 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ..., Carretera Nueva Italia- Uruapan, Kilometro 2, Colonia La Estacion, C.P. 61760, Nueva Italia, Michoac n.... Carretera Nueva Italia- Uruapan, Kilometro 2, Colonia La Estacion, C.P. 61760, Nueva Italia, Michoac...

  3. 77 FR 51616 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ...; Registration ID 388175 (Guatemala) . 5. AUTO HOTEL PUNTO CERO, Kilometro 49.5 Carretera A El Salvador, Aldea El... 71152 (Guatemala) . 7. BOUTIQUE MARLLORY, KM 54.5 Carretera Al Salvador, Santa Rosa, Barberena....1 Carretera El Salvador, Centro Comercial Paseo San Sebastian Local 92, Guatemala City,...

  4. Additive Similarity Trees

    ERIC Educational Resources Information Center

    Sattath, Shmuel; Tversky, Amos

    1977-01-01

    Tree representations of similarity data are investigated. Hierarchical clustering is critically examined, and a more general procedure, called the additive tree, is presented. The additive tree representation is then compared to multidimensional scaling. (Author/JKS)

  5. Polyimide processing additives

    NASA Technical Reports Server (NTRS)

    Pratt, J. R.; St. Clair, T. L.; Burks, H. D.; Stoakley, D. M.

    1987-01-01

    A method has been found for enhancing the melt flow of thermoplastic polyimides during processing. A high molecular weight 422 copoly(amic acid) or copolyimide was fused with approximately 0.05 to 5 pct by weight of a low molecular weight amic acid or imide additive, and this melt was studied by capillary rheometry. Excellent flow and improved composite properties on graphite resulted from the addition of a PMDA-aniline additive to LARC-TPI. Solution viscosity studies imply that amic acid additives temporarily lower molecular weight and, hence, enlarge the processing window. Thus, compositions containing the additive have a lower melt viscosity for a longer time than those unmodified.

  6. [Food additives and healthiness].

    PubMed

    Heinonen, Marina

    2014-01-01

    Additives are used for improving food structure or preventing its spoilage, for example. Many substances used as additives are also naturally present in food. The safety of additives is evaluated according to commonly agreed principles. If high concentrations of an additive cause adverse health effects for humans, a limit of acceptable daily intake (ADI) is set for it. An additive is a risk only when ADI is exceeded. The healthiness of food is measured on the basis of nutrient density and scientifically proven effects.

  7. Rationale, design and methods of the Study of Work and Pain (SWAP): a cluster randomised controlled trial testing the addition of a vocational advice service to best current primary care for patients with musculoskeletal pain (ISRCTN 52269669)

    PubMed Central

    2014-01-01

    Background Musculoskeletal pain is a major contributor to short and long term work absence. Patients seek care from their general practitioner (GP) and yet GPs often feel ill-equipped to deal with work issues. Providing a vocational case management service in primary care, to support patients with musculoskeletal problems to remain at or return to work, is one potential solution but requires robust evaluation to test clinical and cost-effectiveness. Methods/Design This protocol describes a cluster randomised controlled trial, with linked qualitative interviews, to investigate the effect of introducing a vocational advice service into general practice, to provide a structured approach to managing work related issues in primary care patients with musculoskeletal pain who are absent from work or struggling to remain in work. General practices (n = 6) will be randomised to offer best current care or best current care plus a vocational advice service. Adults of working age who are absent from or struggling to remain in work due to a musculoskeletal pain problem will be invited to participate and 330 participants will be recruited. Data collection will be through patient completed questionnaires at baseline, 4 and 12 months. The primary outcome is self-reported work absence at 4 months. Incremental cost-utility analysis will be undertaken to calculate the cost per additional QALY gained and incremental net benefits. A linked interview study will explore the experiences of the vocational advice service from the perspectives of GPs, nurse practitioners (NPs), patients and vocational advisors. Discussion This paper presents the rationale, design, and methods of the Study of Work And Pain (SWAP) trial. The results of this trial will provide evidence to inform primary care practice and guide the development of services to provide support for musculoskeletal pain patients with work-related issues. Trial registration Current Controlled Trials ISRCTN52269669. PMID:25012813

  8. Additive Manufactured Product Integrity

    NASA Technical Reports Server (NTRS)

    Waller, Jess; Wells, Doug; James, Steve; Nichols, Charles

    2017-01-01

    NASA is providing key leadership in an international effort linking NASA and non-NASA resources to speed adoption of additive manufacturing (AM) to meet NASA's mission goals. Participants include industry, NASA's space partners, other government agencies, standards organizations and academia. Nondestructive Evaluation (NDE) is identified as a universal need for all aspects of additive manufacturing.

  9. Polyimide processing additives

    NASA Technical Reports Server (NTRS)

    Fletcher, James C. (Inventor); Pratt, J. Richard (Inventor); St.clair, Terry L. (Inventor); Stoakley, Diane M. (Inventor); Burks, Harold D. (Inventor)

    1992-01-01

    A process for preparing polyimides having enhanced melt flow properties is described. The process consists of heating a mixture of a high molecular weight poly-(amic acid) or polyimide with a low molecular weight amic acid or imide additive in the range of 0.05 to 15 percent by weight of additive. The polyimide powders so obtained show improved processability, as evidenced by lower melt viscosity by capillary rheometry. Likewise, films prepared from mixtures of polymers with additives show improved processability with earlier onset of stretching by TMA.

  10. Polyimide processing additives

    NASA Technical Reports Server (NTRS)

    Pratt, J. Richard (Inventor); St.clair, Terry L. (Inventor); Stoakley, Diane M. (Inventor); Burks, Harold D. (Inventor)

    1993-01-01

    A process for preparing polyimides having enhanced melt flow properties is described. The process consists of heating a mixture of a high molecular weight poly-(amic acid) or polyimide with a low molecular weight amic acid or imide additive in the range of 0.05 to 15 percent by weight of the additive. The polyimide powders so obtained show improved processability, as evidenced by lower melt viscosity by capillary rheometry. Likewise, films prepared from mixtures of polymers with additives show improved processability with earlier onset of stretching by TMA.

  11. Food Additives and Hyperkinesis

    ERIC Educational Resources Information Center

    Wender, Ester H.

    1977-01-01

    The hypothesis that food additives are causally associated with hyperkinesis and learning disabilities in children is reviewed, and available data are summarized. Available from: American Medical Association 535 North Dearborn Street Chicago, Illinois 60610. (JG)

  12. Smog control fuel additives

    SciTech Connect

    Lundby, W.

    1993-06-29

    A method is described of controlling, reducing or eliminating, ozone and related smog resulting from photochemical reactions between ozone and automotive or industrial gases comprising the addition of iodine or compounds of iodine to hydrocarbon-base fuels prior to or during combustion in an amount of about 1 part iodine per 240 to 10,000,000 parts fuel, by weight, to be accomplished by: (a) the addition of these inhibitors during or after the refining or manufacturing process of liquid fuels; (b) the production of these inhibitors for addition into fuel tanks, such as automotive or industrial tanks; or (c) the addition of these inhibitors into combustion chambers of equipment utilizing solid fuels for the purpose of reducing ozone.

  13. Group Sparse Additive Models

    PubMed Central

    Yin, Junming; Chen, Xi; Xing, Eric P.

    2016-01-01

    We consider the problem of sparse variable selection in nonparametric additive models, with the prior knowledge of the structure among the covariates to encourage those variables within a group to be selected jointly. Previous works either study the group sparsity in the parametric setting (e.g., group lasso), or address the problem in the nonparametric setting without exploiting the structural information (e.g., sparse additive models). In this paper, we present a new method, called group sparse additive models (GroupSpAM), which can handle group sparsity in additive models. We generalize the ℓ1/ℓ2 norm to Hilbert spaces as the sparsity-inducing penalty in GroupSpAM. Moreover, we derive a novel thresholding condition for identifying the functional sparsity at the group level, and propose an efficient block coordinate descent algorithm for constructing the estimate. We demonstrate by simulation that GroupSpAM substantially outperforms the competing methods in terms of support recovery and prediction accuracy in additive models, and also conduct a comparative experiment on a real breast cancer dataset.

  14. Additive Manufacturing Infrared Inspection

    NASA Technical Reports Server (NTRS)

    Gaddy, Darrell

    2014-01-01

    Additive manufacturing is a rapid prototyping technology that allows parts to be built in a series of thin layers from plastic, ceramics, and metallics. Metallic additive manufacturing is an emerging form of rapid prototyping that allows complex structures to be built using various metallic powders. Significant time and cost savings have also been observed using the metallic additive manufacturing compared with traditional techniques. Development of the metallic additive manufacturing technology has advanced significantly over the last decade, although many of the techniques to inspect parts made from these processes have not advanced significantly or have limitations. Several external geometry inspection techniques exist such as Coordinate Measurement Machines (CMM), Laser Scanners, Structured Light Scanning Systems, or even traditional calipers and gages. All of the aforementioned techniques are limited to external geometry and contours or must use a contact probe to inspect limited internal dimensions. This presentation will document the development of a process for real-time dimensional inspection technique and digital quality record of the additive manufacturing process using Infrared camera imaging and processing techniques.

  15. Phenylethynyl Containing Reactive Additives

    NASA Technical Reports Server (NTRS)

    Connell, John W. (Inventor); Smith, Joseph G., Jr. (Inventor); Hergenrother, Paul M. (Inventor)

    2002-01-01

    Phenylethynyl containing reactive additives were prepared from aromatic diamine, containing phenylethvnvl groups and various ratios of phthalic anhydride and 4-phenylethynviphthalic anhydride in glacial acetic acid to form the imide in one step or in N-methyl-2-pvrrolidinone to form the amide acid intermediate. The reactive additives were mixed in various amounts (10% to 90%) with oligomers containing either terminal or pendent phenylethynyl groups (or both) to reduce the melt viscosity and thereby enhance processability. Upon thermal cure, the additives react and become chemically incorporated into the matrix and effect an increase in crosslink density relative to that of the host resin. This resultant increase in crosslink density has advantageous consequences on the cured resin properties such as higher glass transition temperature and higher modulus as compared to that of the host resin.

  16. Fused Lasso Additive Model

    PubMed Central

    Petersen, Ashley; Witten, Daniela; Simon, Noah

    2016-01-01

    We consider the problem of predicting an outcome variable using p covariates that are measured on n independent observations, in a setting in which additive, flexible, and interpretable fits are desired. We propose the fused lasso additive model (FLAM), in which each additive function is estimated to be piecewise constant with a small number of adaptively-chosen knots. FLAM is the solution to a convex optimization problem, for which a simple algorithm with guaranteed convergence to a global optimum is provided. FLAM is shown to be consistent in high dimensions, and an unbiased estimator of its degrees of freedom is proposed. We evaluate the performance of FLAM in a simulation study and on two data sets. Supplemental materials are available online, and the R package flam is available on CRAN. PMID:28239246

  17. Phenylethynyl Containing Reactive Additives

    NASA Technical Reports Server (NTRS)

    Connell, John W. (Inventor); Smith, Joseph G., Jr. (Inventor); Hergenrother, Paul M. (Inventor)

    2002-01-01

    Phenylethynyl containing reactive additives were prepared from aromatic diamines containing phenylethynyl groups and various ratios of phthalic anhydride and 4-phenylethynylphthalic anhydride in glacial acetic acid to form the imide in one step or in N-methyl-2-pyrrolidi none to form the amide acid intermediate. The reactive additives were mixed in various amounts (10% to 90%) with oligomers containing either terminal or pendent phenylethynyl groups (or both) to reduce the melt viscosity and thereby enhance processability. Upon thermal cure, the additives react and become chemically incorporated into the matrix and effect an increase in crosslink density relative to that of the host resin. This resultant increase in crosslink density has advantageous consequences on the cured resin properties such as higher glass transition temperature and higher modulus as compared to that of the host resin.

  18. Additives in plastics.

    PubMed Central

    Deanin, R D

    1975-01-01

    The polymers used in plastics are generally harmless. However, they are rarely used in pure form. In almost all commercial plastics, they are "compounded" with monomeric ingredients to improve their processing and end-use performance. In order of total volume used, these monomeric additives may be classified as follows: reinforcing fibers, fillers, and coupling agents; plasticizers; colorants; stabilizers (halogen stabilizers, antioxidants, ultraviolet absorbers, and biological preservatives); processing aids (lubricants, others, and flow controls); flame retardants, peroxides; and antistats. Some information is already available, and much more is needed, on potential toxicity and safe handling of these additives during processing and manufacture of plastics products. PMID:1175566

  19. Additives in plastics.

    PubMed

    Deanin, R D

    1975-06-01

    The polymers used in plastics are generally harmless. However, they are rarely used in pure form. In almost all commercial plastics, they are "compounded" with monomeric ingredients to improve their processing and end-use performance. In order of total volume used, these monomeric additives may be classified as follows: reinforcing fibers, fillers, and coupling agents; plasticizers; colorants; stabilizers (halogen stabilizers, antioxidants, ultraviolet absorbers, and biological preservatives); processing aids (lubricants, others, and flow controls); flame retardants, peroxides; and antistats. Some information is already available, and much more is needed, on potential toxicity and safe handling of these additives during processing and manufacture of plastics products.

  20. Biobased lubricant additives

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fully biobased lubricants are those formulated using all biobased ingredients, i.e. biobased base oils and biobased additives. Such formulations provide the maximum environmental, safety, and economic benefits expected from a biobased product. Currently, there are a number of biobased base oils that...

  1. More Than Additional Space...

    ERIC Educational Resources Information Center

    CEFP Journal, 1973

    1973-01-01

    A much needed addition to the Jamestown Elementary School turned out to be more than an expansion of walls for more space. A new educational program, a limited budget, and a short time line were tackled on a team approach basis and were successfully resolved. (Author)

  2. An Additive Manufacturing Test Artifact

    PubMed Central

    Moylan, Shawn; Slotwinski, John; Cooke, April; Jurrens, Kevin; Donmez, M Alkan

    2014-01-01

    A test artifact, intended for standardization, is proposed for the purpose of evaluating the performance of additive manufacturing (AM) systems. A thorough analysis of previously proposed AM test artifacts as well as experience with machining test artifacts have inspired the design of the proposed test artifact. This new artifact is designed to provide a characterization of the capabilities and limitations of an AM system, as well as to allow system improvement by linking specific errors measured in the test artifact to specific sources in the AM system. The proposed test artifact has been built in multiple materials using multiple AM technologies. The results of several of the builds are discussed, demonstrating how the measurement results can be used to characterize and improve a specific AM system. PMID:26601039

  3. An Additive Manufacturing Test Artifact.

    PubMed

    Moylan, Shawn; Slotwinski, John; Cooke, April; Jurrens, Kevin; Donmez, M Alkan

    2014-01-01

    A test artifact, intended for standardization, is proposed for the purpose of evaluating the performance of additive manufacturing (AM) systems. A thorough analysis of previously proposed AM test artifacts as well as experience with machining test artifacts have inspired the design of the proposed test artifact. This new artifact is designed to provide a characterization of the capabilities and limitations of an AM system, as well as to allow system improvement by linking specific errors measured in the test artifact to specific sources in the AM system. The proposed test artifact has been built in multiple materials using multiple AM technologies. The results of several of the builds are discussed, demonstrating how the measurement results can be used to characterize and improve a specific AM system.

  4. The Frontiers of Additive Manufacturing

    SciTech Connect

    Grote, Christopher John

    2016-03-03

    Additive manufacturing, more commonly known as 3-D printing, has become a ubiquitous tool in science for its precise control over mechanical design. For additive manufacturing to work, a 3-D structure is split into thin 2D slices, and then different physical properties, such as photo-polymerization or melting, are used to grow the sequential layers. The level of control allows not only for devices to be made with a variety of materials: e.g. plastics, metals, and quantum dots, but to also have finely controlled structures leading to other novel properties. While 3-D printing is widely used by hobbyists for making models, it also has industrial applications in structural engineering, biological tissue scaffolding, customized electric circuitry, fuel cells, security, and more.

  5. Advances in Additive Manufacturing

    DTIC Science & Technology

    2016-07-14

    casting molds for traditional casting processes on the battlefield, and 3) the use of recycled polymeric materials as feedstock for 3-D printers ...nondestructive characterization technique allows for 3D imaging that readily captures defects and voids on the conditions that the attenuation, which is...of 3D -printed structures. Analysis examples will include quantification of tolerance differences between the designed and manufactured parts, void

  6. Vinyl capped addition polyimides

    NASA Technical Reports Server (NTRS)

    Vannucci, Raymond D. (Inventor); Malarik, Diane C. (Inventor); Delvigs, Peter (Inventor)

    1991-01-01

    Polyimide resins (PMR) are generally useful where high strength and temperature capabilities are required (at temperatures up to about 700 F). Polyimide resins are particularly useful in applications such as jet engine compressor components, for example, blades, vanes, air seals, air splitters, and engine casing parts. Aromatic vinyl capped addition polyimides are obtained by reacting a diamine, an ester of tetracarboxylic acid, and an aromatic vinyl compound. Low void materials with improved oxidative stability when exposed to 700 F air may be fabricated as fiber reinforced high molecular weight capped polyimide composites. The aromatic vinyl capped polyimides are provided with a more aromatic nature and are more thermally stable than highly aliphatic, norbornenyl-type end-capped polyimides employed in PMR resins. The substitution of aromatic vinyl end-caps for norbornenyl end-caps in addition polyimides results in polymers with improved oxidative stability.

  7. Electrophilic addition of astatine

    SciTech Connect

    Norseev, Yu.V.; Vasaros, L.; Nhan, D.D.; Huan, N.K.

    1988-03-01

    It has been shown for the first time that astatine is capable of undergoing addition reactions to unsaturated hydrocarbons. A new compound of astatine, viz., ethylene astatohydrin, has been obtained, and its retention numbers of squalane, Apiezon, and tricresyl phosphate have been found. The influence of various factors on the formation of ethylene astatohydrin has been studied. It has been concluded on the basis of the results obtained that the univalent cations of astatine in an acidic medium is protonated hypoastatous acid.

  8. Functional Generalized Additive Models.

    PubMed

    McLean, Mathew W; Hooker, Giles; Staicu, Ana-Maria; Scheipl, Fabian; Ruppert, David

    2014-01-01

    We introduce the functional generalized additive model (FGAM), a novel regression model for association studies between a scalar response and a functional predictor. We model the link-transformed mean response as the integral with respect to t of F{X(t), t} where F(·,·) is an unknown regression function and X(t) is a functional covariate. Rather than having an additive model in a finite number of principal components as in Müller and Yao (2008), our model incorporates the functional predictor directly and thus our model can be viewed as the natural functional extension of generalized additive models. We estimate F(·,·) using tensor-product B-splines with roughness penalties. A pointwise quantile transformation of the functional predictor is also considered to ensure each tensor-product B-spline has observed data on its support. The methods are evaluated using simulated data and their predictive performance is compared with other competing scalar-on-function regression alternatives. We illustrate the usefulness of our approach through an application to brain tractography, where X(t) is a signal from diffusion tensor imaging at position, t, along a tract in the brain. In one example, the response is disease-status (case or control) and in a second example, it is the score on a cognitive test. R code for performing the simulations and fitting the FGAM can be found in supplemental materials available online.

  9. Design Methodology of an Equalizer for Unipolar Non Return to Zero Binary Signals in the Presence of Additive White Gaussian Noise Using a Time Delay Neural Network on a Field Programmable Gate Array

    PubMed Central

    Pérez Suárez, Santiago T.; Travieso González, Carlos M.; Alonso Hernández, Jesús B.

    2013-01-01

    This article presents a design methodology for designing an artificial neural network as an equalizer for a binary signal. Firstly, the system is modelled in floating point format using Matlab. Afterward, the design is described for a Field Programmable Gate Array (FPGA) using fixed point format. The FPGA design is based on the System Generator from Xilinx, which is a design tool over Simulink of Matlab. System Generator allows one to design in a fast and flexible way. It uses low level details of the circuits and the functionality of the system can be fully tested. System Generator can be used to check the architecture and to analyse the effect of the number of bits on the system performance. Finally the System Generator design is compiled for the Xilinx Integrated System Environment (ISE) and the system is described using a hardware description language. In ISE the circuits are managed with high level details and physical performances are obtained. In the Conclusions section, some modifications are proposed to improve the methodology and to ensure portability across FPGA manufacturers.

  10. Siloxane containing addition polyimides

    NASA Technical Reports Server (NTRS)

    Maudgal, S.; St. Clair, T. L.

    1984-01-01

    Addition polyimide oligomers have been synthesized from bis(gamma-aminopropyl) tetramethyldisiloxane and 3, 3', 4, 4'-benzophenonetetracarboxylic dianhydride using a variety of latent crosslinking groups as endcappers. The prepolymers were isolated and characterized for solubility (in amide, chlorinated and ether solvents), melt flow and cure properties. The most promising systems, maleimide and acetylene terminated prepolymers, were selected for detailed study. Graphite cloth reinforced composites were prepared and properties compared with those of graphite/Kerimid 601, a commercially available bismaleimide. Mixtures of the maleimide terminated system with Kerimid 601, in varying proportions, were also studied.

  11. Platelet additive solution - electrolytes.

    PubMed

    Azuma, Hiroshi; Hirayama, Junichi; Akino, Mitsuaki; Ikeda, Hisami

    2011-06-01

    Recent attention to solutions that replace most or all plasma in platelet concentrates, while maintaining satisfactory platelet function, is motivated by the potential of plasma reduction or depletion to mitigate various transfusion-related adverse events. This report considers the electrolytic composition of previously described platelet additive solutions, in order to draw general conclusions about what is required for platelet function and longevity. The optimal concentrations of Na(+) and Cl(-) are 69-115 mM. The presence of both K(+) and Mg(2+) in platelet suspension at nearly physiological concentrations (3-5mM and 1.5-3mM, respectively) is indispensable for good preservation capacity because both electrolytes are required to prevent platelet activation. In contrast to K(+) and Mg(2+), Ca(2+) may not be important because no free Ca(2+) is available in M-sol, which showed excellent platelet preservation capacity at less than 5% plasma concentration. The importance of bicarbonate (approximately 40 mM) can be recognized when the platelets are suspended in additive solution under less than 5% residual plasma concentration.

  12. The Additive Coloration of Alkali Halides

    ERIC Educational Resources Information Center

    Jirgal, G. H.; and others

    1969-01-01

    Describes the construction and use of an inexpensive, vacuum furnace designed to produce F-centers in alkali halide crystals by additive coloration. The method described avoids corrosion or contamination during the coloration process. Examination of the resultant crystals is discussed and several experiments using additively colored crystals are…

  13. Additive composition, for gasoline

    SciTech Connect

    Vataru, M.

    1989-01-10

    An admixture is described that comprises Diesel fuel and an additive composition added thereto which is between about 0.05 to about 2.0 percent by weight of the fuel, the composition comprising: (a) between about 0.05 and 25% relative weight parts of an organic peroxide, and (b) between about 0.1 and 25% relative weight parts of detergent selected from the component group that consists of: (i) fatty amines; (ii) ethoxylated and propoxylated derivatives of fatty amines; (iii) fatty diamines; (iv) fatty imidazlines; (v) polymeric amines and derivatives thereof; (vi) combination of one or more of the (i) through (v) components with carboxylic acid or acids having from three to forth carbon atoms, (c) from about 99.0 to about 50% by weight of a hydrocarbon solvent.

  14. Teardrop bladder: additional considerations

    SciTech Connect

    Wechsler, R.J.; Brennan, R.E.

    1982-07-01

    Nine cases of teardrop bladder (TDB) seen at excretory urography are presented. In some of these patients, the iliopsoas muscles were at the upper limit of normal in size, and additional evaluation of the perivesical structures with computed tomography (CT) was necessary. CT demonstrated only hypertrophied muscles with or without perivesical fat. The psoas muscles and pelvic width were measured in 8 patients and compared with the measurements of a control group of males without TDB. Patients with TDB had large iliopsoas muscles and narrow pelves compared with the control group. The psoas muscle width/pelvic width ratio was significantly greater (p < 0.0005) in patients with TDB than in the control group, with values of 1.04 + 0.05 and 0.82 + 0.09, respectively. It is concluded that TDB is not an uncommon normal variant in black males. Both iliopsoas muscle hypertrophy and a narrow pelvis are factors that predispose a patient to TDB.

  15. New addition curing polyimides

    NASA Technical Reports Server (NTRS)

    Frimer, Aryeh A.; Cavano, Paul

    1991-01-01

    In an attempt to improve the thermal-oxidative stability (TOS) of PMR-type polymers, the use of 1,4-phenylenebis (phenylmaleic anhydride) PPMA, was evaluated. Two series of nadic end-capped addition curing polyimides were prepared by imidizing PPMA with either 4,4'-methylene dianiline or p-phenylenediamine. The first resulted in improved solubility and increased resin flow while the latter yielded a compression molded neat resin sample with a T(sub g) of 408 C, close to 70 C higher than PME-15. The performance of these materials in long term weight loss studies was below that of PMR-15, independent of post-cure conditions. These results can be rationalized in terms of the thermal lability of the pendant phenyl groups and the incomplete imidization of the sterically congested PPMA. The preparation of model compounds as well as future research directions are discussed.

  16. Sewage sludge additive

    NASA Technical Reports Server (NTRS)

    Kalvinskas, J. J.; Mueller, W. A.; Ingham, J. D. (Inventor)

    1980-01-01

    The additive is for a raw sewage treatment process of the type where settling tanks are used for the purpose of permitting the suspended matter in the raw sewage to be settled as well as to permit adsorption of the dissolved contaminants in the water of the sewage. The sludge, which settles down to the bottom of the settling tank is extracted, pyrolyzed and activated to form activated carbon and ash which is mixed with the sewage prior to its introduction into the settling tank. The sludge does not provide all of the activated carbon and ash required for adequate treatment of the raw sewage. It is necessary to add carbon to the process and instead of expensive commercial carbon, coal is used to provide the carbon supplement.

  17. [Safety of food additives in Japan].

    PubMed

    Ito, Sumio

    2011-01-01

    Recently, many accidents relating to food happened in Japan. The consumer's distrust for food, food companies, and the administration is increasing. The consumer especially has an extreme refusal feeling for chemicals such as food additives and agricultural chemicals, and begins to request agricultural chemical-free vegetables and food additive-free food. Food companies also state no agricultural chemicals and no food additives to correspond with consumers' request and aim at differentiating. The food additive is that the Ministry of Health, Labour and Welfare specifies the one that person's health might not be ruined by providing for Food Sanitation Law Article 10 in our country. The standard for food additives and standard for use of food additives are provided according to regulations of Food Sanitation Law Article 11. Therefore, it is thought that the food additive used is safe now. Then, it reports on the procedure and the safety examination, etc. in our country for designation for food additive this time.

  18. Additive-driven assembly of block copolymers

    NASA Astrophysics Data System (ADS)

    Lin, Ying; Daga, Vikram; Anderson, Eric; Watkins, James

    2011-03-01

    One challenge to the formation of well ordered hybrid materials is the incorporation of nanoscale additives including metal, semiconductor and dielectric nanoparticles at high loadings while maintaining strong segregation. Here we describe the molecular and functional design of small molecule and nanoparticle additives that enhance phase segregation in their block copolymer host and enable high additive loadings. Our approach includes the use of hydrogen bond interactions between the functional groups on the additive or particle that serve as hydrogen bond donors and one segment of the block copolymer containing hydrogen bond acceptors. Further, the additives show strong selectively towards the targeted domains, leading to enhancements in contrast between properties of the phases. In addition to structural changes, we explore how large changes in the thermal and mechanical properties occur upon incorporation of the additives. Generalization of this additive-induced ordering strategy to various block copolymers will be discussed.

  19. Computational materials design of crystalline solids† †Electronic supplementary information (ESI) available: An extended reading list taken from a snapshot of the Mendeley Group on Materials Design available at https://www.mendeley.com/groups/8113991/materials-design. See DOI: 10.1039/c5cs00841g Click here for additional data file.

    PubMed Central

    Butler, Keith T.; Frost, Jarvist M.; Skelton, Jonathan M.; Svane, Katrine L.

    2016-01-01

    The modelling of materials properties and processes from first principles is becoming sufficiently accurate as to facilitate the design and testing of new systems in silico. Computational materials science is both valuable and increasingly necessary for developing novel functional materials and composites that meet the requirements of next-generation technology. A range of simulation techniques are being developed and applied to problems related to materials for energy generation, storage and conversion including solar cells, nuclear reactors, batteries, fuel cells, and catalytic systems. Such techniques may combine crystal-structure prediction (global optimisation), data mining (materials informatics) and high-throughput screening with elements of machine learning. We explore the development process associated with computational materials design, from setting the requirements and descriptors to the development and testing of new materials. As a case study, we critically review progress in the fields of thermoelectrics and photovoltaics, including the simulation of lattice thermal conductivity and the search for Pb-free hybrid halide perovskites. Finally, a number of universal chemical-design principles are advanced. PMID:26992173

  20. Additive lattice kirigami.

    PubMed

    Castle, Toen; Sussman, Daniel M; Tanis, Michael; Kamien, Randall D

    2016-09-01

    Kirigami uses bending, folding, cutting, and pasting to create complex three-dimensional (3D) structures from a flat sheet. In the case of lattice kirigami, this cutting and rejoining introduces defects into an underlying 2D lattice in the form of points of nonzero Gaussian curvature. A set of simple rules was previously used to generate a wide variety of stepped structures; we now pare back these rules to their minimum. This allows us to describe a set of techniques that unify a wide variety of cut-and-paste actions under the rubric of lattice kirigami, including adding new material and rejoining material across arbitrary cuts in the sheet. We also explore the use of more complex lattices and the different structures that consequently arise. Regardless of the choice of lattice, creating complex structures may require multiple overlapping kirigami cuts, where subsequent cuts are not performed on a locally flat lattice. Our additive kirigami method describes such cuts, providing a simple methodology and a set of techniques to build a huge variety of complex 3D shapes.

  1. Ceramics with Different Additives

    NASA Astrophysics Data System (ADS)

    Wang, Juanjuan; Feng, Lajun; Lei, Ali; Zhao, Kang; Yan, Aijun

    2014-09-01

    Li2CO3, MgCO3, BaCO3, and Bi2O3 dopants were introduced into CaCu3Ti4O12 (CCTO) ceramics in order to improve the dielectric properties. The CCTO ceramics were prepared by conventional solid-state reaction method. The phase structure, microstructure, and dielectric behavior were carefully investigated. The pure structure without any impurity phases can be confirmed by the x-ray diffraction patterns. Scanning Electron Microscopy (SEM) analysis illuminated that the grains of Ca0.90Li0.20Cu3Ti4O12 ceramics were greater than that of pure CCTO. It was important for the properties of the CCTO ceramics to study the additives in complex impedance spectroscopy. It was found that the Ca0.90Li0.20Cu3Ti4O12 ceramics had the higher permittivity (>45000), the lower dielectric loss (<0.025) than those of CCTO at 1 kHz at room temperature and good temperature stability from -30 to 75 °C.

  2. Additive lattice kirigami

    PubMed Central

    Castle, Toen; Sussman, Daniel M.; Tanis, Michael; Kamien, Randall D.

    2016-01-01

    Kirigami uses bending, folding, cutting, and pasting to create complex three-dimensional (3D) structures from a flat sheet. In the case of lattice kirigami, this cutting and rejoining introduces defects into an underlying 2D lattice in the form of points of nonzero Gaussian curvature. A set of simple rules was previously used to generate a wide variety of stepped structures; we now pare back these rules to their minimum. This allows us to describe a set of techniques that unify a wide variety of cut-and-paste actions under the rubric of lattice kirigami, including adding new material and rejoining material across arbitrary cuts in the sheet. We also explore the use of more complex lattices and the different structures that consequently arise. Regardless of the choice of lattice, creating complex structures may require multiple overlapping kirigami cuts, where subsequent cuts are not performed on a locally flat lattice. Our additive kirigami method describes such cuts, providing a simple methodology and a set of techniques to build a huge variety of complex 3D shapes. PMID:27679822

  3. Electrochemical performance evaluations and safety investigations of pentafluoro(phenoxy)cyclotriphosphazene as a flame retardant electrolyte additive for application in lithium ion battery systems using a newly designed apparatus for improved self-extinguishing time measurements

    NASA Astrophysics Data System (ADS)

    Dagger, Tim; Lürenbaum, Constantin; Schappacher, Falko M.; Winter, Martin

    2017-02-01

    A modified self-extinguishing time (SET) device which enhances the reproducibility of the results is presented. Pentafluoro(phenoxy)cyclotriphosphazene (FPPN) is investigated as flame retardant electrolyte additive for lithium ion batteries (LIBs) in terms of thermal stability and electrochemical performance. SET measurements and adiabatic reaction calorimetry are applied to determine the flammability and the reactivity of a standard LIB electrolyte containing 5% FPPN. The results reveal that the additive-containing electrolyte is nonflammable for 10 s whereas the commercially available reference electrolyte inflames instantaneously after 1 s of ignition. The onset temperature of the safety enhanced electrolyte is delayed by ≈ 21 °C. Compatibility tests in half cells show that the electrolyte is reductively stable while the cyclic voltammogram indicates oxidative decomposition during the first cycle. Cycling experiments in full cells show improved cycling performance and rate capability, which can be attributed to cathode passivation during the first cycle. Post-mortem analysis of the electrolyte by gas chromatography-mass spectrometry confirms the presence of the additive in high amounts after 501 cycles which ensures enhanced safety of the electrolyte. The investigations present FPPN as stable electrolyte additive that improves the intrinsic safety of the electrolyte and its cycling performance at the same time.

  4. Optics of progressive addition lenses.

    PubMed

    Sheedy, J E; Buri, M; Bailey, I L; Azus, J; Borish, I M

    1987-02-01

    The optical characteristics of the major progressive addition lenses were measured using an automated lensometer with a specially designed lens holder to simulate eye rotation. Measurements were made every 3 degrees (about 1.5 mm) and graphs of isospherical equivalent lines and isocylinder lines were developed. Generally the near zone of these lenses is narrower and lower than in bifocal or trifocal lenses. Distinct differences exist between the various progressive lenses. The width of the near zone, rate of power progression, amount of unwanted cylinder (level with the distance center), and clarity of the distance zone are compared for the various lenses. The optical measurements demonstrate an apparent trade-off between the size of the cylinder-free area of the lens and the amount of the cylinder.

  5. High Flow Addition Curing Polyimides

    NASA Technical Reports Server (NTRS)

    Chuang, Kathy C.; Vannucci, Raymond D.; Ansari, Irfan; Cerny, Lawrence L.; Scheiman, Daniel A.

    1994-01-01

    A new series of high flow PMR-type addition curing polyimides was developed, which employed the substitution of 2,2'-bis (trifluoromethyl) -4,4'-diaminobiphenyl (BTDB) for p-phenylenediamine (p -PDA) in a PMR-IL formulation. These thermoset polyimides, designated as 12F resins, were prepared from BTDB and the dimethyl ester of 4,4'- (hexafluo- roisopropylidene) -diphthalic acid (HFDE) with either nadic ester (NE) or p-aminostyrene (PAS) as the endcaps for addition curing. The 12F prepolymers displayed lower melting temperatures in DSC analysis, and higher melt flow in rheological studies than the cor- responding PMR-11 polyimides. Long-term isothermal aging studies showed that BTDB- based 12F resins exhibited comparable thermo-oxidative stability to P-PDA based PMR-11 polyimides. The noncoplanar 2- and 2'-disubstituted biphenyldiamine (BTDB) not only lowered the melt viscosities of 12F prepolymers, but also retained reasonable thermal sta- bility of the cured resins. The 12F polyimide resin with p-aminostyrene endcaps showed the best promise for long-term, high-temperature application at 343 C (650 F).

  6. Bespoke contrast-matched diblock copolymer nanoparticles enable the rational design of highly transparent Pickering double emulsions† †Electronic supplementary information (ESI) available: GPC chromatograms, additional transmission electron micrographs, digital photographs, visible absorption spectra and laser diffraction data, further optical and fluorescence micrographs. See DOI: 10.1039/c6nr03856e Click here for additional data file.

    PubMed Central

    Thompson, Kate L.; Derry, Matthew J.; Warren, Nicholas J.; Ratcliffe, Liam P. D.; Williams, Clive N.; Brown, Steven L.

    2016-01-01

    We report the preparation of highly transparent oil-in-water Pickering emulsions using contrast-matched organic nanoparticles. This is achieved via addition of judicious amounts of either sucrose or glycerol to an aqueous dispersion of poly(glycerol monomethacrylate)56–poly(2,2,2-trifluoroethyl methacrylate)500 [PGMA–PTFEMA] diblock copolymer nanoparticles prior to high shear homogenization with an equal volume of n-dodecane. The resulting Pickering emulsions comprise polydisperse n-dodecane droplets of 20–100 μm diameter and exhibit up to 96% transmittance across the visible spectrum. In contrast, control experiments using non-contrast-matched poly(glycerol monomethacrylate)56–poly(benzyl methacrylate)300 [PGMA56–PBzMA300] diblock copolymer nanoparticles as a Pickering emulsifier only produced conventional highly turbid emulsions. Thus contrast-matching of the two immiscible phases is a necessary but not sufficient condition for the preparation of highly transparent Pickering emulsions: it is essential to use isorefractive nanoparticles in order to minimize light scattering. Furthermore, highly transparent oil-in-water-in-oil Pickering double emulsions can be obtained by homogenizing the contrast-matched oil-in-water Pickering emulsion prepared using the PGMA56–PTFEMA500 nanoparticles with a contrast-matched dispersion of hydrophobic poly(lauryl methacrylate)39–poly(2,2,2-trifluoroethyl methacrylate)800 [PLMA39–PTFEMA800] diblock copolymer nanoparticles in n-dodecane. Finally, we show that an isorefractive oil-in-water Pickering emulsion enables fluorescence spectroscopy to be used to monitor the transport of water-insoluble small molecules (pyrene and benzophenone) between n-dodecane droplets. Such transport is significantly less efficient than that observed for the equivalent isorefractive surfactant-stabilized emulsion. Conventional turbid emulsions do not enable such a comparison to be made because the intense light scattering leads to

  7. Design of underwater superoleophobic TiO2 coatings with additional photo-induced self-cleaning properties by one-step route bio-inspired from fish scales

    NASA Astrophysics Data System (ADS)

    Wang, Hao; Guo, Zhiguang

    2014-05-01

    Self-cleaning properties inspired by the structures and functions of some creatures are of great interest since the late 20th century. In this paper, TiO2 coatings with hierarchical rutile TiO2 flowers on fluorine-doped tin oxide substrate are fabricated through a simple one-step hydrothermal method. The flower-like coatings exhibit superhydrophilicity in air and superoleophobicity underwater with a contact angle as high as 157°, presenting good underwater self-cleaning performance. In addition, when contaminated by oleic acid, the as-prepared TiO2 coatings also exhibit excellent photocatalytic capability under ultraviolet irradiation, which demonstrated self-cleaning properties in a different way. This self-cleaning film provides a good strategy for some industrial and ocean applications.

  8. Design of underwater superoleophobic TiO{sub 2} coatings with additional photo-induced self-cleaning properties by one-step route bio-inspired from fish scales

    SciTech Connect

    Wang, Hao; Guo, Zhiguang

    2014-05-05

    Self-cleaning properties inspired by the structures and functions of some creatures are of great interest since the late 20th century. In this paper, TiO{sub 2} coatings with hierarchical rutile TiO{sub 2} flowers on fluorine-doped tin oxide substrate are fabricated through a simple one-step hydrothermal method. The flower-like coatings exhibit superhydrophilicity in air and superoleophobicity underwater with a contact angle as high as 157°, presenting good underwater self-cleaning performance. In addition, when contaminated by oleic acid, the as-prepared TiO{sub 2} coatings also exhibit excellent photocatalytic capability under ultraviolet irradiation, which demonstrated self-cleaning properties in a different way. This self-cleaning film provides a good strategy for some industrial and ocean applications.

  9. Neutron Characterization for Additive Manufacturing

    NASA Technical Reports Server (NTRS)

    Watkins, Thomas; Bilheux, Hassina; An, Ke; Payzant, Andrew; DeHoff, Ryan; Duty, Chad; Peter, William; Blue, Craig; Brice, Craig A.

    2013-01-01

    Oak Ridge National Laboratory (ORNL) is leveraging decades of experience in neutron characterization of advanced materials together with resources such as the Spallation Neutron Source (SNS) and the High Flux Isotope Reactor (HFIR) shown in Fig. 1 to solve challenging problems in additive manufacturing (AM). Additive manufacturing, or three-dimensional (3-D) printing, is a rapidly maturing technology wherein components are built by selectively adding feedstock material at locations specified by a computer model. The majority of these technologies use thermally driven phase change mechanisms to convert the feedstock into functioning material. As the molten material cools and solidifies, the component is subjected to significant thermal gradients, generating significant internal stresses throughout the part (Fig. 2). As layers are added, inherent residual stresses cause warping and distortions that lead to geometrical differences between the final part and the original computer generated design. This effect also limits geometries that can be fabricated using AM, such as thin-walled, high-aspect- ratio, and overhanging structures. Distortion may be minimized by intelligent toolpath planning or strategic placement of support structures, but these approaches are not well understood and often "Edisonian" in nature. Residual stresses can also impact component performance during operation. For example, in a thermally cycled environment such as a high-pressure turbine engine, residual stresses can cause components to distort unpredictably. Different thermal treatments on as-fabricated AM components have been used to minimize residual stress, but components still retain a nonhomogeneous stress state and/or demonstrate a relaxation-derived geometric distortion. Industry, federal laboratory, and university collaboration is needed to address these challenges and enable the U.S. to compete in the global market. Work is currently being conducted on AM technologies at the ORNL

  10. Additives in fibers and fabrics.

    PubMed Central

    Barker, R H

    1975-01-01

    The additives and contaminants which occur in textile fibers vary widely, depending on the type of fiber and the pretreatment which it has received. Synthetic fibers such as nylon and polyester contain trace amounts of contaminants such as catalysts and catalyst deactivators which remain after the synthesis of the basic polymers. In addition, there are frequently a number of materials which are added to perform specific functions in almost all man-made fibers. Examples of these would include traces of metals or metal salts used as tracers for identification of specific lots of fiber, TiO2 or similar materials added as delustrants, and a host of organic species added for such special purposes as antistatic agents or flame retardants. There may also be considerable quantities of residual monomer or small oligomers dissolved in the polymer matrix. The situation becomes even more complex after the fibers are converted into fabric form. Numerous materials are applied at various stages of fabric preparation to act as lubricants, sizing agents, antistats, bleaches, and wetting agents to facilitate the processing, but these are normally removed before the fabric reaches the cutters of the ultimate consumers and therefore usually do not constitute potential hazards. However, there are many other chemical agents which are frequently added during the later stages of fabric preparation and which are not designed to be removed. Aside from dyes and printing pigments, the most common additive for apparel fabrics is a durable press treatment. This generally involves the use of materials capable of crosslinking cellulosics by reacting through such functions as N-methylolated amides or related compounds such as ureas and carbamates. These materials pose some potential hazards due to both the nitrogenous bases and the formaldehyde which they usually release. There is usually also some residual catalyst in fabrics which have received such treatments. Other types of chemical treatments

  11. Dynamical systems techniques for designing libration point orbits in proximity of highly-inhomogeneous planetary satellites: Application to the Mars-Phobos elliptic three-body problem with additional gravity harmonics

    NASA Astrophysics Data System (ADS)

    Zamaro, Mattia; Biggs, James D.

    2014-12-01

    The orbital dynamics around the Libration points of the classical circular restricted three-body problem (CR3BP) have been investigated in detail: in the last few decades, dynamical systems theory has provided invaluable analytical and numerical tools for understanding the dynamics of Libration Point Orbits (LPOs). The aim of this paper is to extend the model of the CR3BP to derive the LPOs in the vicinity of the Martian moon Phobos, which is becoming an appealing destination for scientific missions. The case of Phobos is particularly extreme, since the combination of both small mass-ratio and length-scale moves the collinear Libration manifold close to the moon's surface. Thus, a model of this system must consider additional dynamical perturbations, in particular the complete gravity field of Phobos, which is highly-inhomogeneous. This is accomplished using a spherical harmonics series expansion, deriving an enhanced elliptic three-body model. In this paper, we show how methodologies from dynamical systems theory are applied in differential correction continuation schemes to this proposed nonlinear model of the dynamics near Phobos, to derive the structure of the dynamical substitutes of the LPOs in this new system. Results obtained show that the structure of the LPOs differs substantially from the classical case without harmonics. The proposed methodology allows us to identify natural periodic and quasi-periodic orbits that would provide unique low-cost opportunities for close-range observations around Phobos and high-performance landing/take-off pathways to and from Phobos' surface, which could be exploited in upcoming missions targeting the exploration of this Martian moon.

  12. 3D-additive manufactured optical mount

    NASA Astrophysics Data System (ADS)

    Mammini, Paul V.; Ciscel, David; Wooten, John

    2015-09-01

    The Area Defense Anti-Munitions (ADAM) is a low cost and effective high power laser weapon system. It's designed to address and negate important threats such as short-range rockets, UAVs, and small boats. Many critical optical components operate in the system. The optics and mounts must accommodate thermal and mechanical stresses, plus maintain an exceptional wave front during operation. Lockheed Martin Space Systems Company (LMSSC) developed, designed, and currently operates ADAM. This paper covers the design and development of a key monolithic, flexured, titanium mirror mount that was manufactured by CalRAM using additive processes.

  13. Additive Manufacturing: From Rapid Prototyping to Flight

    NASA Technical Reports Server (NTRS)

    Prater, Tracie

    2015-01-01

    Additive manufacturing (AM) offers tremendous promise for the rocket propulsion community. Foundational work must be performed to ensure the safe performance of AM parts. Government, industry, and academia must collaborate in the characterization, design, modeling, and process control to accelerate the certification of AM parts for human-rated flight.

  14. College of Architecture Addition, Burchard Hall.

    ERIC Educational Resources Information Center

    Design Cost Data, 2001

    2001-01-01

    Describes the architectural design, costs, general description, and square footage data for the College of Architecture Addition, Burchard Hall in Blacksburg, Virginia. A floor plan and photos are included along with a list of manufacturers and suppliers used for the project. (GR)

  15. How Safe Are Color Additives?

    MedlinePlus

    ... Home For Consumers Consumer Updates How Safe are Color Additives? Share Tweet Linkedin Pin it More sharing ... Consumer Updates RSS Feed Download PDF (380 K) Color additives give the red tint to your fruit ...

  16. Detergent Additive for Lubricating Oils,

    DTIC Science & Technology

    The Russian patent pertains to a method of producing additives for lubricating oils . A method is known for producing an antiwear additive for... lubricating oils by processing phenols with phosphorus oxychloride, phosphoric acid esters are obtained. In order to give the additive detergent properties

  17. Incorporation of additives into polymers

    DOEpatents

    McCleskey, T. Mark; Yates, Matthew Z.

    2003-07-29

    There has been invented a method for incorporating additives into polymers comprising: (a) forming an aqueous or alcohol-based colloidal system of the polymer; (b) emulsifying the colloidal system with a compressed fluid; and (c) contacting the colloidal polymer with the additive in the presence of the compressed fluid. The colloidal polymer can be contacted with the additive by having the additive in the compressed fluid used for emulsification or by adding the additive to the colloidal system before or after emulsification with the compressed fluid. The invention process can be carried out either as a batch process or as a continuous on-line process.

  18. 28 CFR 571.72 - Additional designated offenses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... pornography or related paraphernalia; (3) Any sexual contact with a minor or other person physically or...) 134-S1 (Kidnaping of a minor (by a person not a parent)); (13) 134-Z (Pornography involving a...

  19. 28 CFR 571.72 - Additional designated offenses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... pornography or related paraphernalia; (3) Any sexual contact with a minor or other person physically or...) 134-S1 (Kidnaping of a minor (by a person not a parent)); (13) 134-Z (Pornography involving a...

  20. 28 CFR 571.72 - Additional designated offenses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... pornography or related paraphernalia; (3) Any sexual contact with a minor or other person physically or...) 134-S1 (Kidnaping of a minor (by a person not a parent)); (13) 134-Z (Pornography involving a...

  1. 28 CFR 571.72 - Additional designated offenses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... pornography or related paraphernalia; (3) Any sexual contact with a minor or other person physically or...) 134-S1 (Kidnaping of a minor (by a person not a parent)); (13) 134-Z (Pornography involving a...

  2. 28 CFR 571.72 - Additional designated offenses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., or sexual battery); (2) Possession, distribution, mailing, production, or receipt of child... instrument, encouraging use of a minor for prostitution purposes, incest); (5) An attempt to commit any...

  3. Breaking Barriers in Polymer Additive Manufacturing

    SciTech Connect

    Love, Lonnie J; Duty, Chad E; Post, Brian K; Lind, Randall F; Lloyd, Peter D; Kunc, Vlastimil; Peter, William H; Blue, Craig A

    2015-01-01

    Additive Manufacturing (AM) enables the creation of complex structures directly from a computer-aided design (CAD). There are limitations that prevent the technology from realizing its full potential. AM has been criticized for being slow and expensive with limited build size. Oak Ridge National Laboratory (ORNL) has developed a large scale AM system that improves upon each of these areas by more than an order of magnitude. The Big Area Additive Manufacturing (BAAM) system directly converts low cost pellets into a large, three-dimensional part at a rate exceeding 25 kg/h. By breaking these traditional barriers, it is possible for polymer AM to penetrate new manufacturing markets.

  4. Information Design: A Bibliography.

    ERIC Educational Resources Information Center

    Albers, Michael J.; Lisberg, Beth Conney

    2000-01-01

    Presents a 17-item annotated list of essential books on information design chosen by members of the InfoDesign e-mail list. Includes a 113-item unannotated bibliography of additional works, on topics of creativity and critical thinking; visual thinking; graphic design; infographics; information design; instructional design; interface design;…

  5. Enantioselective Michael addition of water.

    PubMed

    Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

    2015-02-09

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry.

  6. Enantioselective Michael Addition of Water

    PubMed Central

    Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

    2015-01-01

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry. PMID:25529526

  7. Predicting the performance of batteries having paste additives

    SciTech Connect

    Edwards, D.B.; Cantrell, R.L.; Dayton, T.C.

    1997-12-01

    This paper discusses how models previously developed at the University of Idaho can be used to design high performance batteries containing paste additives. One model characterizes the conductivity of the active material. With this model, the influence of different additives, both conductive and nonconductive, on the capacity of paste containing these additives can be evaluated. The results of this analysis is then used in a second model to characterize the performance of cells. The models are used in the paper to help design and evaluate a battery for a hybrid electric vehicle. This design example illustrates how the models can be used to investigate unique designs for electric and hybrid electric vehicles.

  8. Navy Additive Manufacturing: Adding Parts, Subtracting Steps

    DTIC Science & Technology

    2015-06-01

    DOD Department of Defense DON Department of Navy DREAMS Design, Research, and Education for Additive Manufacturing EBM electron beam melting...Current market leader in SLM technology is the German company EOS (Lou & Grosvenor, 2012, “Sold and Sold Again: 1997-Present”).  Electron Beam Melting...EBM): EBM was invented by the Swedish corporation Arcam. Unlike other Powder Bed Techniques, “EBM uses an electron beam rather than a laser and

  9. Color Addition and Subtraction Apps

    ERIC Educational Resources Information Center

    Ruiz, Frances; Ruiz, Michael J.

    2015-01-01

    Color addition and subtraction apps in HTML5 have been developed for students as an online hands-on experience so that they can more easily master principles introduced through traditional classroom demonstrations. The evolution of the additive RGB color model is traced through the early IBM color adapters so that students can proceed step by step…

  10. Additive Effects on Asymmetric Catalysis.

    PubMed

    Hong, Liang; Sun, Wangsheng; Yang, Dongxu; Li, Guofeng; Wang, Rui

    2016-03-23

    This review highlights a number of additives that can be used to make asymmetric reactions perfect. Without changing other reaction conditions, simply adding additives can lead to improved asymmetric catalysis, such as reduced reaction time, improved yield, or/and increased selectivity.

  11. Additively manufactured metallic pentamode meta-materials

    NASA Astrophysics Data System (ADS)

    Hedayati, R.; Leeflang, A. M.; Zadpoor, A. A.

    2017-02-01

    Mechanical metamaterials exhibit unusual mechanical properties that originate from their topological design. Pentamode metamaterials are particularly interesting because they could be designed to possess any thermodynamically admissible elasticity tensor. In this study, we additively manufacture the metallic pentamode metamaterials from a biocompatible and mechanically strong titanium alloy (Ti-6Al-4V) using an energy distribution method developed for the powder bed fusion techniques. The mechanical properties of the developed materials were a few orders of magnitude higher than those of the similar topologies fabricated previously from polymers. Moreover, the elastic modulus and yield stress of the presented pentamode metamaterials were decoupled from their relative density, meaning that the metallic meta-biomaterials with independently tailored elastic and mass transport (permeability) properties could be designed for tissue regeneration purposes.

  12. Evaluation of advanced polymers for additive manufacturing

    SciTech Connect

    Rios, Orlando; Morrison, Crystal

    2015-09-01

    The goal of this Manufacturing Demonstration Facility (MDF) technical collaboration project between Oak Ridge National Laboratory (ORNL) and PPG Industries, Inc. was to evaluate the feasibility of using conventional coatings chemistry and technology to build up material layer-by-layer. The PPG-ORNL study successfully demonstrated that polymeric coatings formulations may overcome many limitations of common thermoplastics used in additive manufacturing (AM), allow lightweight nozzle design for material deposition and increase build rate. The materials effort focused on layer-by-layer deposition of coatings with each layer fusing together. The combination of materials and deposition results in an additively manufactured build that has sufficient mechanical properties to bear the load of additional layers, yet is capable of bonding across the z-layers to improve build direction strength. The formulation properties were tuned to enable a novel, high-throughput deposition method that is highly scalable, compatible with high loading of reinforcing fillers, and is inherently low-cost.

  13. Additive manufacturing of materials: Opportunities and challenges

    SciTech Connect

    Babu, Sudarsanam Suresh; Love, Lonnie J.; Dehoff, Ryan R.; Peter, William H.; Watkins, Thomas R.; Pannala, Sreekanth

    2015-11-01

    Additive manufacturing (also known as 3D printing) is considered a disruptive technology for producing components with topologically optimized complex geometries as well as functionalities that are not achievable by traditional methods. The realization of the full potential of 3D printing is stifled by a lack of computational design tools, generic material feedstocks, techniques for monitoring thermomechanical processes under in situ conditions, and especially methods for minimizing anisotropic static and dynamic properties brought about by microstructural heterogeneity. In this paper, we discuss the role of interdisciplinary research involving robotics and automation, process control, multiscale characterization of microstructure and properties, and high-performance computational tools to address each of these challenges. In addition, emerging pathways to scale up additive manufacturing of structural materials to large sizes (>1 m) and higher productivities (5–20 kg/h) while maintaining mechanical performance and geometrical flexibility are also discussed.

  14. Additive manufacturing of materials: Opportunities and challenges

    DOE PAGES

    Babu, Sudarsanam Suresh; Love, Lonnie J.; Dehoff, Ryan R.; ...

    2015-11-01

    Additive manufacturing (also known as 3D printing) is considered a disruptive technology for producing components with topologically optimized complex geometries as well as functionalities that are not achievable by traditional methods. The realization of the full potential of 3D printing is stifled by a lack of computational design tools, generic material feedstocks, techniques for monitoring thermomechanical processes under in situ conditions, and especially methods for minimizing anisotropic static and dynamic properties brought about by microstructural heterogeneity. In this paper, we discuss the role of interdisciplinary research involving robotics and automation, process control, multiscale characterization of microstructure and properties, and high-performancemore » computational tools to address each of these challenges. In addition, emerging pathways to scale up additive manufacturing of structural materials to large sizes (>1 m) and higher productivities (5–20 kg/h) while maintaining mechanical performance and geometrical flexibility are also discussed.« less

  15. Adverse reactions to drug additives.

    PubMed

    Simon, R A

    1984-10-01

    There is a long list of additives used by the pharmaceutical industry. Most of the agents used have not been implicated in hypersensitivity reactions. Among those that have, only reactions to parabens and sulfites have been well established. Parabens have been shown to be responsible for rare immunoglobulin E-mediated reactions that occur after the use of local anesthetics. Sulfites, which are present in many drugs, including agents commonly used to treat asthma, have been shown to provoke severe asthmatic attacks in sensitive individuals. Recent studies indicate that additives do not play a significant role in "hyperactivity." The role of additives in urticaria is not well established and therefore the incidence of adverse reactions in this patient population is simply not known. In double-blind, placebo-controlled studies, reactions to tartrazine or additives other than sulfites, if they occur at all, are indeed quite rare for the asthmatic population, even for the aspirin-sensitive subpopulation.

  16. Radiation Therapy: Additional Treatment Options

    MedlinePlus

    ... SNIPEND SNIPSTART Find A Radiation Oncologist SNIPEND Additional Treatment Options SNIPSTART A A SNIPEND Chemotherapy Medicines prescribed ... such as antibodies, to fight cancer. Novel Targeted Therapies Cancer doctors now know much more about how ...

  17. Calculators and Computers: Graphical Addition.

    ERIC Educational Resources Information Center

    Spero, Samuel W.

    1978-01-01

    A computer program is presented that generates problem sets involving sketching graphs of trigonometric functions using graphical addition. The students use calculators to sketch the graphs and a computer solution is used to check it. (MP)

  18. Food additives and preschool children.

    PubMed

    Martyn, Danika M; McNulty, Breige A; Nugent, Anne P; Gibney, Michael J

    2013-02-01

    Food additives have been used throughout history to perform specific functions in foods. A comprehensive framework of legislation is in place within Europe to control the use of additives in the food supply and ensure they pose no risk to human health. Further to this, exposure assessments are regularly carried out to monitor population intakes and verify that intakes are not above acceptable levels (acceptable daily intakes). Young children may have a higher dietary exposure to chemicals than adults due to a combination of rapid growth rates and distinct food intake patterns. For this reason, exposure assessments are particularly important in this age group. The paper will review the use of additives and exposure assessment methods and examine factors that affect dietary exposure by young children. One of the most widely investigated unfavourable health effects associated with food additive intake in preschool-aged children are suggested adverse behavioural effects. Research that has examined this relationship has reported a variety of responses, with many noting an increase in hyperactivity as reported by parents but not when assessed using objective examiners. This review has examined the experimental approaches used in such studies and suggests that efforts are needed to standardise objective methods of measuring behaviour in preschool children. Further to this, a more holistic approach to examining food additive intakes by preschool children is advisable, where overall exposure is considered rather than focusing solely on behavioural effects and possibly examining intakes of food additives other than food colours.

  19. Additively Manufactured and Surface Biofunctionalized Porous Nitinol.

    PubMed

    Gorgin Karaji, Z; Speirs, M; Dadbakhsh, S; Kruth, J-P; Weinans, H; Zadpoor, A A; Amin Yavari, S

    2017-01-18

    Enhanced bone tissue regeneration and improved osseointegration are among the most important goals in design of multifunctional orthopedic biomaterials. In this study, we used additive manufacturing (selective laser melting) to develop multifunctional porous nitinol that combines superelasticity with a rationally designed microarchitecture and biofunctionalized surface. The rational design based on triply periodic minimal surfaces aimed to properly adjust the pore size, increase the surface area (thereby amplifying the effects of surface biofunctionalization), and resemble the curvature characteristics of trabecular bone. The surface of additively manufactured (AM) porous nitinol was biofunctionalized using polydopamine-immobilized rhBMP2 for better control of the release kinetics. The actual morphological properties of porous nitinol measured by microcomputed tomography (e.g., open/close porosity, and surface area) closely matched the design values. The superelasticity originated from the austenite phase formed in the nitinol porous structure at room temperature. Polydopamine and rhBMP2 signature peaks were confirmed by X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy tests. The release of rhBMP2 continued until 28 days. The early time and long-term release profiles were found to be adjustable independent of each other. In vitro cell culture showed improved cell attachment, cell proliferation, cell morphology (spreading, spindle-like shape), and cell coverage as well as elevated levels of ALP activity and increased calcium content for biofunctionalized surfaces as compared to as-manufactured specimens. The demonstrated functionalities of porous nitinol could be used as a basis for deployable orthopedic implants with rationally designed microarchitectures that maximize bone tissue regeneration performance by release of biomolecules with adjustable and well-controlled release profiles.

  20. Evaluation of certain food additives.

    PubMed

    2015-01-01

    This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, and to prepare specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of and assessment of dietary exposure to food additives, including flavouring agents. A summary follows of the Committee's evaluations of technical, toxicological and dietary exposure data for eight food additives (Benzoe tonkinensis; carrageenan; citric and fatty acid esters of glycerol; gardenia yellow; lutein esters from Tagetes erecta; octenyl succinic acid-modified gum arabic; octenyl succinic acid-modified starch; paprika extract; and pectin) and eight groups of flavouring agents (aliphatic and alicyclic hydrocarbons; aliphatic and aromatic ethers; ionones and structurally related substances; miscellaneous nitrogen-containing substances; monocyclic and bicyclic secondary alcohols, ketones and related esters; phenol and phenol derivatives; phenyl-substituted aliphatic alcohols and related aldehydes and esters; and sulfur-containing heterocyclic compounds). Specifications for the following food additives were revised: citric acid; gellan gum; polyoxyethylene (20) sorbitan monostearate; potassium aluminium silicate; and Quillaia extract (Type 2). Annexed to the report are tables summarizing the Committee's recommendations for dietary exposures to and toxicological evaluations of all of the food additives and flavouring agents considered at this meeting.

  1. [INVITED] Lasers in additive manufacturing

    NASA Astrophysics Data System (ADS)

    Pinkerton, Andrew J.

    2016-04-01

    Additive manufacturing is a topic of considerable ongoing interest, with forecasts predicting it to have major impact on industry in the future. This paper focusses on the current status and potential future development of the technology, with particular reference to the role of lasers within it. It begins by making clear the types and roles of lasers in the different categories of additive manufacturing. This is followed by concise reviews of the economic benefits and disadvantages of the technology, current state of the market and use of additive manufacturing in different industries. Details of these fields are referenced rather than expanded in detail. The paper continues, focusing on current indicators to the future of additive manufacturing. Barriers to its development, trends and opportunities in major industrial sectors, and wider opportunities for its development are covered. Evidence indicates that additive manufacturing may not become the dominant manufacturing technology in all industries, but represents an excellent opportunity for lasers to increase their influence in manufacturing as a whole.

  2. Additive manufacturing in production: challenges and opportunities

    NASA Astrophysics Data System (ADS)

    Ahuja, Bhrigu; Karg, Michael; Schmidt, Michael

    2015-03-01

    Additive manufacturing, characterized by its inherent layer by layer fabrication methodology has been coined by many as the latest revolution in the manufacturing industry. Due to its diversification of Materials, processes, system technology and applications, Additive Manufacturing has been synonymized with terminology such as Rapid prototyping, 3D printing, free-form fabrication, Additive Layer Manufacturing, etc. A huge media and public interest in the technology has led to an innovative attempt of exploring the technology for applications beyond the scope of the traditional engineering industry. Nevertheless, it is believed that a critical factor for the long-term success of Additive Manufacturing would be its ability to fulfill the requirements defined by the traditional manufacturing industry. A parallel development in market trends and product requirements has also lead to a wider scope of opportunities for Additive Manufacturing. The presented paper discusses some of the key challenges which are critical to ensure that Additive Manufacturing is truly accepted as a mainstream production technology in the industry. These challenges would highlight on various aspects of production such as product requirements, process management, data management, intellectual property, work flow management, quality assurance, resource planning, etc. In Addition, changing market trends such as product life cycle, mass customization, sustainability, environmental impact and localized production will form the foundation for the follow up discussion on the current limitations and the corresponding research opportunities. A discussion on ongoing research to address these challenges would include topics like process monitoring, design complexity, process standardization, multi-material and hybrid fabrication, new material development, etc.

  3. Additive manufacturing of hybrid circuits

    SciTech Connect

    Bell, Nelson S.; Sarobol, Pylin; Cook, Adam; Clem, Paul G.; Keicher, David M.; Hirschfeld, Deidre; Hall, Aaron Christopher

    2016-03-26

    There is a rising interest in developing functional electronics using additively manufactured components. Considerations in materials selection and pathways to forming hybrid circuits and devices must demonstrate useful electronic function; must enable integration; and must complement the complex shape, low cost, high volume, and high functionality of structural but generally electronically passive additively manufactured components. This article reviews several emerging technologies being used in industry and research/development to provide integration advantages of fabricating multilayer hybrid circuits or devices. First, we review a maskless, noncontact, direct write (DW) technology that excels in the deposition of metallic colloid inks for electrical interconnects. Second, we review a complementary technology, aerosol deposition (AD), which excels in the deposition of metallic and ceramic powder as consolidated, thick conformal coatings and is additionally patternable through masking. As a result, we show examples of hybrid circuits/devices integrated beyond 2-D planes, using combinations of DW or AD processes and conventional, established processes.

  4. Tougher Addition Polyimides Containing Siloxane

    NASA Technical Reports Server (NTRS)

    St. Clair, T. L.; Maudgal, S.

    1986-01-01

    Laminates show increased impact resistances and other desirable mechanical properties. Bismaleamic acid extended by reaction of diaminosiloxane with maleic anhydride in 1:1 molar ratio, followed by reaction with half this molar ratio of aromatic dianhydride. Bismaleamic acid also extended by reaction of diaminosiloxane with maleic anhydride in 1:2 molar ratio, followed by reaction with half this molar ratio of aromatic diamine (Michael-addition reaction). Impact resistances improved over those of unmodified bismaleimide, showing significant increase in toughness. Aromatic addition polyimides developed as both matrix and adhesive resins for applications on future aircraft and spacecraft.

  5. Embedding Sensors During Additive Manufacturing

    SciTech Connect

    Sbriglia, Lexey Raylene

    2015-08-10

    This PowerPoint presentation had the following headings: Fused deposition modeling (FDM); Open source 3D printing; Objectives; Vibration analysis; Equipment; Design; Material choices; Failure causes, such as tension, bubbling; Potential solutions; Simulations; Embedding the sensors; LabView programming; Alternate data acquisition; Problem and proposed solution; and, Conclusions

  6. Responses to additional JAPC questions

    SciTech Connect

    Burke, T.M.

    1998-02-03

    The goals are to improve performance and reduce costs; the variables tested are fuel fabrication and assembly tolerances and cladding materials. Significant results are: goal lifetimes achieved; D9/HT9 alloys superior--reduced swelling potential duct mechanical attachment methods viable; test performance per design predictions.

  7. The Additive Property of Energy.

    ERIC Educational Resources Information Center

    Tsaoussis, Dimitris S.

    1995-01-01

    Presents exercises that analyze the additive property of energy. Concludes that if a body has more than one component of energy depending on the same physical quantity, the body's total energy will be the algebraic sum of the components if a linear relationship exists between the energy components and that physical quantity. (JRH)

  8. Tetrasulfide extreme pressure lubricant additives

    SciTech Connect

    Gast, L.E.; Kenney, H.E.; Schwab, A.W.

    1980-08-19

    A novel class of compounds has been prepared comprising the tetrasulfides of /sup 18/C hydrocarbons, /sup 18/C fatty acids, and /sup 18/C fatty and alkyl and triglyceride esters. These tetrasulfides are useful as extreme pressure lubricant additives and show potential as replacements for sulfurized sperm whale oil.

  9. Out of bounds additive manufacturing

    SciTech Connect

    Holshouser, Chris; Newell, Clint; Palas, Sid; Love, Lonnie J.; Kunc, Vlastimil; Lind, Randall F.; Lloyd, Peter D.; Rowe, John C.; Blue, Craig A.; Duty, Chad E.; Peter, William H.; Dehoff, Ryan R.

    2013-03-01

    Lockheed Martin and Oak Ridge National Laboratory are working on an additive manufacturing system capable of manufacturing components measured not in terms of inches or feet, but multiple yards in all dimensions with the potential to manufacture parts that are completely unbounded in size.

  10. Evaluation of certain food additives.

    PubMed

    2012-01-01

    This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, with a view to concluding as to safety concerns and to preparing specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of and assessment of dietary exposure to food additives, including flavouring agents. A summary follows of the Committee's evaluations of technical, toxicological and dietary exposure data for five food additives (magnesium dihydrogen diphosphate; mineral oil (medium and low viscosity) classes II and III; 3-phytase from Aspergillus niger expressed in Aspergillus niger; serine protease (chymotrypsin) from Nocardiopsis prasina expressed in Bacillus licheniformis; and serine protease (trypsin) from Fusarium oxysporum expressed in Fusarium venenatum) and 16 groups of flavouring agents (aliphatic and aromatic amines and amides; aliphatic and aromatic ethers; aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers containing furan substitution; aliphatic linear alpha,beta-unsaturated aldehydes, acids and related alcohols, acetals and esters; amino acids and related substances; epoxides; furfuryl alcohol and related substances; linear and branched-chain aliphatic, unsaturated, unconjugated alcohols, aldehydes, acids and related esters; miscellaneous nitrogen-containing substances; phenol and phenol derivatives; pyrazine derivatives; pyridine, pyrrole and quinoline derivatives; saturated aliphatic acyclic branched-chain primary alcohols, aldehydes and acids; simple aliphatic and aromatic sulfides and thiols; sulfur-containing heterocyclic compounds; and sulfur-substituted furan derivatives). Specifications for the following food additives were revised: ethyl cellulose, mineral oil (medium viscosity), modified starches and titanium

  11. The teratology testing of food additives.

    PubMed

    Barrow, Paul C; Spézia, François

    2013-01-01

    The developmental and reproductive toxicity testing (including teratogenicity) of new foods and food additives is performed worldwide according to the guidelines given in the FDA Redbook. These studies are not required for substances that are generally recognized as safe, according to the FDA inventory. The anticipated cumulated human exposure level above which developmental or reproduction studies are required depends on the structure-alert category. For food additives of concern, both developmental (prenatal) and reproduction (multigeneration) studies are required. The developmental studies are performed in two species, usually the rat and the rabbit. The reproduction study is generally performed in the rat. The two rat studies are preferably combined into a single experimental design, if possible. The test methods described in the FDA Redbook are similar to those specified by the OECD for the reproductive toxicity testing of chemicals.

  12. PDII- Additional discussion of the dynamic aperture

    SciTech Connect

    Norman M. Gelfand

    2002-07-23

    This note is in the nature of an addition to the dynamic aperture calculations found in the report on the Proton Driver, FERMILAB-TM-2169. A extensive discussion of the Proton Driver lattice, as well as the nomenclature used to describe it can be found in TM-2169. Basically the proposed lattice is a racetrack design with the two arcs joined by two long straight sections. The straight sections are dispersion free. Tracking studies were undertaken with the objective of computing the dynamic aperture for the lattice and some of the results have been incorporated into TM-2169. This note is a more extensive report of those calculations.

  13. Collaborative Design

    ERIC Educational Resources Information Center

    Broderick, Debora

    2014-01-01

    This practitioner research study investigates the power of multimodal texts within a real-world context and argues that a participatory culture focused on literary arts offers marginalized high school students opportunities for collaborative design and authoring. Additionally, this article invites educators to rethink the at-risk label. This…

  14. Additive Manufacturing for Affordable Rocket Engines

    NASA Technical Reports Server (NTRS)

    West, Brian; Robertson, Elizabeth; Osborne, Robin; Calvert, Marty

    2016-01-01

    Additive manufacturing (also known as 3D printing) technology has the potential to drastically reduce costs and lead times associated with the development of complex liquid rocket engine systems. NASA is using 3D printing to manufacture rocket engine components including augmented spark igniters, injectors, turbopumps, and valves. NASA is advancing the process to certify these components for flight. Success Story: MSFC has been developing rocket 3D-printing technology using the Selective Laser Melting (SLM) process. Over the last several years, NASA has built and tested several injectors and combustion chambers. Recently, MSFC has 3D printed an augmented spark igniter for potential use the RS-25 engines that will be used on the Space Launch System. The new design is expected to reduce the cost of the igniter by a factor of four. MSFC has also 3D printed and tested a liquid hydrogen turbopump for potential use on an Upper Stage Engine. Additive manufacturing of the turbopump resulted in a 45% part count reduction. To understanding how the 3D printed parts perform and to certify them for flight, MSFC built a breadboard liquid rocket engine using additive manufactured components including injectors, turbomachinery, and valves. The liquid rocket engine was tested seven times in 2016 using liquid oxygen and liquid hydrogen. In addition to exposing the hardware to harsh environments, engineers learned to design for the new manufacturing technique, taking advantage of its capabilities and gaining awareness of its limitations. Benefit: The 3D-printing technology promises reduced cost and schedule for rocket engines. Cost is a function of complexity, and the most complicated features provide the largest opportunities for cost reductions. This is especially true where brazes or welds can be eliminated. The drastic reduction in part count achievable with 3D printing creates a waterfall effect that reduces the number of processes and drawings, decreases the amount of touch

  15. Decontamination formulation with sorbent additive

    DOEpatents

    Tucker; Mark D. , Comstock; Robert H.

    2007-10-16

    A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a bleaching activator, a sorbent additive, and water. The highly adsorbent, water-soluble sorbent additive (e.g., sorbitol or mannitol) is used to "dry out" one or more liquid ingredients, such as the liquid bleaching activator (e.g., propylene glycol diacetate or glycerol diacetate) and convert the activator into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field.

  16. Additive Manufacturing Integrated Energy Demonstration

    SciTech Connect

    Jackson, Roderick; Lee, Brian; Love, Lonnie; Mabe, Gavin; Keller, Martin; Curran, Scott; Chinthavali, Madhu; Green, Johney; Sawyer, Karma; Enquist, Phil

    2016-02-05

    Meet AMIE - the Additive Manufacturing Integrated Energy demonstration project. Led by Oak Ridge National Laboratory and many industry partners, the AMIE project changes the way we think about generating, storing, and using electrical power. AMIE uses an integrated energy system that shares energy between a building and a vehicle. And, utilizing advanced manufacturing and rapid innovation, it only took one year from concept to launch.

  17. Robust stability under additive perturbations

    NASA Technical Reports Server (NTRS)

    Bhaya, A.; Desoer, C. A.

    1985-01-01

    A MIMO linear time-invariant feedback system 1S(P,C) is considered which is assumed to be U-stable. The plant P is subjected to an additive perturbation Delta P which is proper but not necessarily stable. It is proved that the perturbed system is U-stable if and only if Delta P(I + Q x Delta P) exp -1 is U-stable.

  18. Additive Manufacturing Integrated Energy Demonstration

    ScienceCinema

    Jackson, Roderick; Lee, Brian; Love, Lonnie; Mabe, Gavin; Keller, Martin; Curran, Scott; Chinthavali, Madhu; Green, Johney; Sawyer, Karma; Enquist, Phil

    2016-07-12

    Meet AMIE - the Additive Manufacturing Integrated Energy demonstration project. Led by Oak Ridge National Laboratory and many industry partners, the AMIE project changes the way we think about generating, storing, and using electrical power. AMIE uses an integrated energy system that shares energy between a building and a vehicle. And, utilizing advanced manufacturing and rapid innovation, it only took one year from concept to launch.

  19. Nanoengineered Additives for Active Coatings

    DTIC Science & Technology

    2007-04-01

    commercial ad bial activ component from the coating, leading to eventual depletion of the film. Small TPU samples were evaluated using a Kirby - Bauer ...7 Table 5. Summary of 24-hr ASTM E 2180 tests with 1 weight-percent additive in PUr (solvent dispersible) based on 6-log loading of...Noveon X-1150). The ASTM E 2180 test is run in triplicate (Note that alternative ro 1° amines) was suspended in dry tetrahydrofuran (THF) (150 mL) in

  20. Reversible Oxidative Addition at Carbon.

    PubMed

    Eichhorn, Antonius F; Fuchs, Sonja; Flock, Marco; Marder, Todd B; Radius, Udo

    2017-04-07

    The reactivity of N-heterocyclic carbenes (NHCs) and cyclic alkyl amino carbenes (cAACs) with arylboronate esters is reported. The reaction with NHCs leads to the reversible formation of thermally stable Lewis acid/base adducts Ar-B(OR)2 ⋅NHC (Add1-Add6). Addition of cAAC(Me) to the catecholboronate esters 4-R-C6 H4 -Bcat (R=Me, OMe) also afforded the adducts 4-R-C6 H4 Bcat⋅cAAC(Me) (Add7, R=Me and Add8, R=OMe), which react further at room temperature to give the cAAC(Me) ring-expanded products RER1 and RER2. The boronate esters Ar-B(OR)2 of pinacol, neopentylglycol, and ethyleneglycol react with cAAC at RT via reversible B-C oxidative addition to the carbene carbon atom to afford cAAC(Me) (B{OR}2 )(Ar) (BCA1-BCA6). NMR studies of cAAC(Me) (Bneop)(4-Me-C6 H4 ) (BCA4) demonstrate the reversible nature of this oxidative addition process.

  1. Additive manufacturing of hybrid circuits

    DOE PAGES

    Bell, Nelson S.; Sarobol, Pylin; Cook, Adam; ...

    2016-03-26

    There is a rising interest in developing functional electronics using additively manufactured components. Considerations in materials selection and pathways to forming hybrid circuits and devices must demonstrate useful electronic function; must enable integration; and must complement the complex shape, low cost, high volume, and high functionality of structural but generally electronically passive additively manufactured components. This article reviews several emerging technologies being used in industry and research/development to provide integration advantages of fabricating multilayer hybrid circuits or devices. First, we review a maskless, noncontact, direct write (DW) technology that excels in the deposition of metallic colloid inks for electrical interconnects.more » Second, we review a complementary technology, aerosol deposition (AD), which excels in the deposition of metallic and ceramic powder as consolidated, thick conformal coatings and is additionally patternable through masking. As a result, we show examples of hybrid circuits/devices integrated beyond 2-D planes, using combinations of DW or AD processes and conventional, established processes.« less

  2. Fire-Retardant Polymeric Additives

    NASA Technical Reports Server (NTRS)

    Williams, Martha K.; Smith, Trent M.

    2011-01-01

    Polyhydroxyamide (PHA) and polymethoxyamide (PMeOA) are fire-retardant (FR) thermoplastic polymers and have been found to be useful as an additive for imparting fire retardant properties to other compatible, thermoplastic polymers (including some elastomers). Examples of compatible flammable polymers include nylons, polyesters, and acrylics. Unlike most prior additives, PHA and PMeOA do not appreciably degrade the mechanical properties of the matrix polymer; indeed, in some cases, mechanical properties are enhanced. Also, unlike some prior additives, PHA and PMeOA do not decompose into large amounts of corrosive or toxic compounds during combustion and can be processed at elevated temperatures. PMeOA derivative formulations were synthesized and used as an FR additive in the fabrication of polyamide (PA) and polystyrene (PS) composites with notable reduction (>30 percent for PS) in peak heat release rates compared to the neat polymer as measured by a Cone Calorimeter (ASTM E1354). Synergistic effects were noted with nanosilica composites. These nanosilica composites had more than 50-percent reduction in peak heat release rates. In a typical application, a flammable thermoplastic, thermoplastic blend, or elastomer that one seeks to render flame-retardant is first dry-mixed with PHA or PMeOA or derivative thereof. The proportion of PHA or PMeOA or derivative in the mixture is typically chosen to lie between 1 and 20 weight percent. The dry blend can then be melt-extruded. The extruded polymer blend can further be extruded and/or molded into fibers, pipes, or any other of a variety of objects that may be required to be fire-retardant. The physical and chemical mechanisms which impart flame retardancy of the additive include inhibiting free-radical oxidation in the vapor phase, preventing vaporization of fuel (the polymer), and cooling through the formation of chemical bonds in either the vapor or the condensed phase. Under thermal stress, the cyclic hydroxyl/ methoxy

  3. Evaluation of certain food additives.

    PubMed

    2009-01-01

    This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, with a view to recommending acceptable daily intakes (ADIs) and to preparing specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation and assessment of intake of food additives (in particular, flavouring agents). A summary follows of the Committee's evaluations of technical, toxicological and intake data for certain food additives (asparaginase from Aspergillus niger expressed in A. niger, calcium lignosulfonate (40-65), ethyl lauroyl arginate, paprika extract, phospholipase C expressed in Pichia pastoris, phytosterols, phytostanols and their esters, polydimethylsiloxane, steviol glycosides and sulfites [assessment of dietary exposure]) and 10 groups of related flavouring agents (aliphatic branched-chain saturated and unsaturated alcohols, aldehydes, acids and related esters; aliphatic linear alpha,beta-unsaturated aldehydes, acids and related alcohols, acetals and esters; aliphatic secondary alcohols, ketones and related esters; alkoxy-substituted allylbenzenes present in foods and essential oils and used as flavouring agents; esters of aliphatic acyclic primary alcohols with aliphatic linear saturated carboxylic acids; furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers; miscellaneous nitrogen-containing substances; monocyclic and bicyclic secondary alcohols, ketones and related esters; hydroxy- and alkoxy-substituted benzyl derivatives; and substances structurally related to menthol). Specifications for the following food additives were revised: canthaxanthin; carob bean gum and carob bean gum (clarified); chlorophyllin copper complexes, sodium and potassium salts; Fast Green FCF; guar gum and guar gum (clarified

  4. 29 CFR 1602.19 - Additional reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION RECORDKEEPING....19 Additional reporting requirements. The Commission reserves the right to require reports, other than that designated as Report EEO-2, about apprenticeship procedures of joint...

  5. 29 CFR 1602.19 - Additional reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION RECORDKEEPING....19 Additional reporting requirements. The Commission reserves the right to require reports, other than that designated as Report EEO-2, about apprenticeship procedures of joint...

  6. The Mozart Effect: Additional Data.

    PubMed

    Hughes, John R.

    2002-04-01

    After the review of the Mozart effect was published in this journal (Hughes JR. Epilepsy Behav 2001;2:369-417), additional data from the music of Haydn and Liszt have been analyzed that may account for the decrease in seizure activity originally reported during Mozart music. Even with these added data Mozart music continued to score significantly higher than the selections from the other six composers in one of the important characteristics of this music, namely, the repetition of the melody. However Haydn's values were second highest among Mozart, J. S. Bach, Wagner, Beethoven, Chopin, and Liszt.

  7. Water based drilling mud additive

    SciTech Connect

    McCrary, J.L.

    1983-12-13

    A water based fluid additive useful in drilling mud used during drilling of an oil or gas well is disclosed, produced by reacting water at temperatures between 210/sup 0/-280/sup 0/ F. with a mixture comprising in percent by weight: gilsonite 25-30%, tannin 7-15%, lignite 25-35%, sulfonating compound 15-25%, water soluble base compound 5-15%, methylene-yielding compound 1-5%, and then removing substantially all of the remaining water to produce a dried product.

  8. Metal Additive Manufacturing: A Review

    NASA Astrophysics Data System (ADS)

    Frazier, William E.

    2014-06-01

    This paper reviews the state-of-the-art of an important, rapidly emerging, manufacturing technology that is alternatively called additive manufacturing (AM), direct digital manufacturing, free form fabrication, or 3D printing, etc. A broad contextual overview of metallic AM is provided. AM has the potential to revolutionize the global parts manufacturing and logistics landscape. It enables distributed manufacturing and the productions of parts-on-demand while offering the potential to reduce cost, energy consumption, and carbon footprint. This paper explores the material science, processes, and business consideration associated with achieving these performance gains. It is concluded that a paradigm shift is required in order to fully exploit AM potential.

  9. Theatre fleet's vital additional capacity.

    PubMed

    2012-11-01

    Vanguard Healthcare's fleet of mobile surgical facilities has been deployed to healthcare sites throughout Europe and beyond for over a decade, providing vital additional clinical capacity when existing buildings are refurbished or upgraded, in the event of flood or fire, or simply to help hospitals cater for rising demand. It is a combination of careful planning, teamwork, and the specialist expertise of Vanguard's personnel--many with a clinical background--that ensures not only each unit's successful installation, but equally its subsequent running, servicing, and maintenance, the company explains.

  10. Shale JP-4 Additive Evaluation

    DTIC Science & Technology

    1986-10-01

    8217. •% . , ’ ,,,r ,% . -- - ,.-. ’ ’ 4,w% %’. " - ,’ . . . * ’, .* . TABLE OF CONTENTS .4q ,4 . * SECTION PAGE I. INTRODUCTION 1 II. TEST PARAMETERS 2 1...42 PRECEDING PAGE BLANK TABLE OF CONTENTS (CON’T) SECT ION PAGE V. CONCLUSIONS 44 REFERENCES 46 APPENDIX A Drum to Test Sample Relationship 47 APPENDIX...B.O.C.L.E. Results 40 vii LIST OF TABLES TABLE PAGE 1 Antioxidants 3 2 Raw Shale/Petroleum Fuel Properties 10 3 Drum Sample Additive Content 13 4

  11. Additive and Photochemical Manufacturing of Copper

    NASA Astrophysics Data System (ADS)

    Yung, Winco K. C.; Sun, Bo; Meng, Zhengong; Huang, Junfeng; Jin, Yingdi; Choy, Hang Shan; Cai, Zhixiang; Li, Guijun; Ho, Cheuk Lam; Yang, Jinlong; Wong, Wai Yeung

    2016-12-01

    In recent years, 3D printing technologies have been extensively developed, enabling rapid prototyping from a conceptual design to an actual product. However, additive manufacturing of metals in the existing technologies is still cost-intensive and time-consuming. Herein a novel platform for low-cost additive manufacturing is introduced by simultaneously combining the laser-induced forward transfer (LIFT) method with photochemical reaction. Using acrylonitrile butadiene styrene (ABS) polymer as the sacrificial layer, sufficient ejection momentum can be generated in the LIFT method. A low-cost continuous wave (CW) laser diode at 405 nm was utilized and proved to be able to transfer the photochemically synthesized copper onto the target substrate. The wavelength-dependent photochemical behaviour in the LIFT method was verified and characterized by both theoretical and experimental studies compared to 1064 nm fiber laser. The conductivity of the synthesized copper patterns could be enhanced using post electroless plating while retaining the designed pattern shapes. Prototypes of electronic circuits were accordingly built and demonstrated for powering up LEDs. Apart from pristine PDMS materials with low surface energies, the proposed method can simultaneously perform laser-induced forward transfer and photochemical synthesis of metals, starting from their metal oxide forms, onto various target substrates such as polyimide, glass and thermoplastics.

  12. Additive and Photochemical Manufacturing of Copper

    PubMed Central

    Yung, Winco K. C.; Sun, Bo; Meng, Zhengong; Huang, Junfeng; Jin, Yingdi; Choy, Hang Shan; Cai, Zhixiang; Li, Guijun; Ho, Cheuk Lam; Yang, Jinlong; Wong, Wai Yeung

    2016-01-01

    In recent years, 3D printing technologies have been extensively developed, enabling rapid prototyping from a conceptual design to an actual product. However, additive manufacturing of metals in the existing technologies is still cost-intensive and time-consuming. Herein a novel platform for low-cost additive manufacturing is introduced by simultaneously combining the laser-induced forward transfer (LIFT) method with photochemical reaction. Using acrylonitrile butadiene styrene (ABS) polymer as the sacrificial layer, sufficient ejection momentum can be generated in the LIFT method. A low-cost continuous wave (CW) laser diode at 405 nm was utilized and proved to be able to transfer the photochemically synthesized copper onto the target substrate. The wavelength-dependent photochemical behaviour in the LIFT method was verified and characterized by both theoretical and experimental studies compared to 1064 nm fiber laser. The conductivity of the synthesized copper patterns could be enhanced using post electroless plating while retaining the designed pattern shapes. Prototypes of electronic circuits were accordingly built and demonstrated for powering up LEDs. Apart from pristine PDMS materials with low surface energies, the proposed method can simultaneously perform laser-induced forward transfer and photochemical synthesis of metals, starting from their metal oxide forms, onto various target substrates such as polyimide, glass and thermoplastics. PMID:28000733

  13. Additive and Photochemical Manufacturing of Copper.

    PubMed

    Yung, Winco K C; Sun, Bo; Meng, Zhengong; Huang, Junfeng; Jin, Yingdi; Choy, Hang Shan; Cai, Zhixiang; Li, Guijun; Ho, Cheuk Lam; Yang, Jinlong; Wong, Wai Yeung

    2016-12-21

    In recent years, 3D printing technologies have been extensively developed, enabling rapid prototyping from a conceptual design to an actual product. However, additive manufacturing of metals in the existing technologies is still cost-intensive and time-consuming. Herein a novel platform for low-cost additive manufacturing is introduced by simultaneously combining the laser-induced forward transfer (LIFT) method with photochemical reaction. Using acrylonitrile butadiene styrene (ABS) polymer as the sacrificial layer, sufficient ejection momentum can be generated in the LIFT method. A low-cost continuous wave (CW) laser diode at 405 nm was utilized and proved to be able to transfer the photochemically synthesized copper onto the target substrate. The wavelength-dependent photochemical behaviour in the LIFT method was verified and characterized by both theoretical and experimental studies compared to 1064 nm fiber laser. The conductivity of the synthesized copper patterns could be enhanced using post electroless plating while retaining the designed pattern shapes. Prototypes of electronic circuits were accordingly built and demonstrated for powering up LEDs. Apart from pristine PDMS materials with low surface energies, the proposed method can simultaneously perform laser-induced forward transfer and photochemical synthesis of metals, starting from their metal oxide forms, onto various target substrates such as polyimide, glass and thermoplastics.

  14. New ESP additive controls particulates

    SciTech Connect

    Durham, M.D.; Baldrey, K.E.; Bustard, C.J.; Martin, C.E.; Dharmarajan, N.N.

    1997-06-01

    This article reports that a conditioning agent enhanced precipitator performance after plant switched to low-sulfur coal. Firing low-sulfur coal at a power plant designed for medium- or high-sulfur coal will impact the downstream particulate control device. Since the performance of an electro-static precipitator (ESP) is a strong function of the sulfur content in the coal, switching to a low-sulfur coal will severely impact collection efficiency. Particle resistivity is the dominant parameter affecting the performance of an ESP. When the resistivity is too high, the ESP must be increased in size by a factor of two to three, resulting in proportionally increased capital and operating costs. Fly ash from low-sulfur coal is known to have a typical resistivity one or two orders of magnitude above that for ideal collection efficiency in a well-designed ESP. Therefore, when a utility burning a medium- or high-sulfur coal switches to a low-sulfur coal, the increase in particle resistivity resulting from the reduced SO{sub 3} concentration will lead to severe problems in the ESP. There have been many instances where utilities have switched from a high- to a low-sulfur coal, and the problems caused by the increased resistivity have had such a devastating effect on the performance of the ESP that emissions have increased by a factor of 10.

  15. Fuel Additives: Canada bans MMT

    SciTech Connect

    Sissell, K.

    1997-04-16

    The Canadian Senate voted late last week to ban use of the manganese-based fuel additive MMT, produced only in the US by Ethyl. MMT, which has been sold in Canada for the past 20 years and accounts for about half of Ethyl`s Canadian sales, has been criticized by environmentalists, who have raised public health concerns, and automakers, who say it harms emission control systems. {open_quotes}Canada`s vote is a great victory for public health and the environment,{close_quotes} says Environmental Defense Fund executive director Fred Krupp. {open_quotes}The US should move swiftly to follow suit and suspend sales of MMT until adequate toxicity testing on the additive is completed.{close_quotes} EPA had refused to approve MMT for sale because of health concerns but was compelled to do so by a December 1995 court ruling. Ethyl asserts the ban violates Canada`s obligations under Nafta and says it will file a damage claim with the Nafta arbitration panel.

  16. Additive interaction between heterogeneous environmental ...

    EPA Pesticide Factsheets

    BACKGROUND Environmental exposures often occur in tandem; however, epidemiological research often focuses on singular exposures. Statistical interactions among broad, well-characterized environmental domains have not yet been evaluated in association with health. We address this gap by conducting a county-level cross-sectional analysis of interactions between Environmental Quality Index (EQI) domain indices on preterm birth in the Unites States from 2000-2005.METHODS: The EQI, a county-level index constructed for the 2000-2005 time period, was constructed from five domain-specific indices (air, water, land, built and sociodemographic) using principal component analyses. County-level preterm birth rates (n=3141) were estimated using live births from the National Center for Health Statistics. Linear regression was used to estimate prevalence differences (PD) and 95% confidence intervals (CI) comparing worse environmental quality to the better quality for each model for a) each individual domain main effect b) the interaction contrast and c) the two main effects plus interaction effect (i.e. the “net effect”) to show departure from additive interaction for the all U.S counties. Analyses were also performed for subgroupings by four urban/rural strata. RESULTS: We found the suggestion of antagonistic interactions but no synergism, along with several purely additive (i.e., no interaction) associations. In the non-stratified model, we observed antagonistic interac

  17. Additive manufacturing of RF absorbers

    NASA Astrophysics Data System (ADS)

    Mills, Matthew S.

    The ability of additive manufacturing techniques to fabricate integrated electromagnetic absorbers tuned for specific radio frequency bands within structural composites allows for unique combinations of mechanical and electromagnetic properties. These composites and films can be used for RF shielding of sensitive electromagnetic components through in-plane and out-of-plane RF absorption. Structural composites are a common building block of many commercial platforms. These platforms may be placed in situations in which there is a need for embedded RF absorbing properties along with structural properties. Instead of adding radar absorbing treatments to the external surface of existing structures, which adds increased size, weight and cost; it could prove to be advantageous to integrate the microwave absorbing properties directly into the composite during the fabrication process. In this thesis, a method based on additive manufacturing techniques of composites structures with prescribed electromagnetic loss, within the frequency range 1 to 26GHz, is presented. This method utilizes screen printing and nScrypt micro dispensing to pattern a carbon based ink onto low loss substrates. The materials chosen for this study will be presented, and the fabrication technique that these materials went through to create RF absorbing structures will be described. The calibration methods used, the modeling of the RF structures, and the applications in which this technology can be utilized will also be presented.

  18. Structure Property Studies for Additively Manufactured Parts

    SciTech Connect

    Milenski, Helen M; Schmalzer, Andrew Michael; Kelly, Daniel

    2015-08-17

    Since the invention of modern Additive Manufacturing (AM) processes engineers and designers have worked hard to capitalize on the unique building capabilities that AM allows. By being able to customize the interior fill of parts it is now possible to design components with a controlled density and customized internal structure. The creation of new polymers and polymer composites allow for even greater control over the mechanical properties of AM parts. One of the key reasons to explore AM, is to bring about a new paradigm in part design, where materials can be strategically optimized in a way that conventional subtractive methods cannot achieve. The two processes investigated in my research were the Fused Deposition Modeling (FDM) process and the Direct Ink Write (DIW) process. The objectives of the research were to determine the impact of in-fill density and morphology on the mechanical properties of FDM parts, and to determine if DIW printed samples could be produced where the filament diameter was varied while the overall density remained constant.

  19. High School Science Technology Additions, Midland Public Schools.

    ERIC Educational Resources Information Center

    Design Cost Data, 2001

    2001-01-01

    Discusses design goals, space requirements, and need for mobile furniture and "imagination stations" at Michigan's Midland Public High School science technology addition. Describes the architectural design, costs, and specifications. Includes floor plans, general description, photos and a list of consultants, manufacturers, and suppliers…

  20. 30 CFR 18.32 - Fastenings-additional requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.32 Fastenings—additional requirements. (a) Bolts, screws, or studs shall.... Special fastenings designed to prevent loosening will be acceptable in lieu of lockwashers, provided...

  1. 30 CFR 18.32 - Fastenings-additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.32 Fastenings—additional requirements. (a) Bolts, screws, or studs shall.... Special fastenings designed to prevent loosening will be acceptable in lieu of lockwashers, provided...

  2. Diesel fuel detergent additive performance and assessment

    SciTech Connect

    Vincent, M.W.; Papachristos, M.J.; Williams, D.; Burton, J.

    1994-10-01

    Diesel fuel detergent additives are increasingly linked with high quality automotive diesel fuels. Both in Europe and in the USA, field problems associated with fuel injector coking or fouling have been experienced. In Europe indirect injection (IDI) light duty engines used in passenger cars were affected, while in the USA, a direct injection (DI) engine in heavy duty truck applications experienced field problems. In both cases, a fuel additive detergent performance test has evolved using an engine linked with the original field problem, although engine design modifications employed by the manufacturers have ensured improved operation in service. Increasing awareness of the potential for injector nozzle coking to cause deterioration in engine performance is coupled with a need to meet ever more stringent exhaust emissions legislation. These two requirements indicate that the use of detergency additives will continue to be associated with high quality diesel fuels. The paper examines detergency performance evaluated in a range of IDI and DI engines and correlates performance in the two most widely recognised test engines, namely the Peugeot 1.9 litre IDI, and Cummins L10 DI engines. 17 refs., 18 figs., 5 tabs.

  3. 48 CFR 22.406-3 - Additional classifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Involving Construction 22.406-3 Additional classifications. (a) If any laborer or mechanic is to be employed... mechanics to be employed in the additional classification (if known) or their representatives agree to the... any amount designated for fringe benefits); or (2) If the contractor, the laborers or mechanics to...

  4. 48 CFR 22.406-3 - Additional classifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Involving Construction 22.406-3 Additional classifications. (a) If any laborer or mechanic is to be employed... mechanics to be employed in the additional classification (if known) or their representatives agree to the... any amount designated for fringe benefits); or (2) If the contractor, the laborers or mechanics to...

  5. 48 CFR 22.406-3 - Additional classifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Involving Construction 22.406-3 Additional classifications. (a) If any laborer or mechanic is to be employed... mechanics to be employed in the additional classification (if known) or their representatives agree to the... any amount designated for fringe benefits); or (2) If the contractor, the laborers or mechanics to...

  6. 48 CFR 22.406-3 - Additional classifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Involving Construction 22.406-3 Additional classifications. (a) If any laborer or mechanic is to be employed... mechanics to be employed in the additional classification (if known) or their representatives agree to the... any amount designated for fringe benefits); or (2) If the contractor, the laborers or mechanics to...

  7. 78 FR 38069 - Expansion of Global Entry to Additional Airports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... SECURITY U.S. Customs and Border Protection Expansion of Global Entry to Additional Airports AGENCY: U.S... airports. This document announces the expansion of the program to include eight additional designated... the Federal Register and post the information on the Web site http://www.globalentry.gov ....

  8. 7 CFR 3201.103 - Gasoline fuel additives.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Gasoline fuel additives. 3201.103 Section 3201.103... Designated Items § 3201.103 Gasoline fuel additives. (a) Definition. Chemical agents added to gasoline to increase octane levels, improve lubricity, and provide engine cleaning properties to gasoline-fired...

  9. 7 CFR 3201.13 - Diesel fuel additives.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Diesel fuel additives. 3201.13 Section 3201.13... Designated Items § 3201.13 Diesel fuel additives. (a) Definition. (1) Any substance, other than one composed solely of carbon and/or hydrogen, that is intentionally added to diesel fuel (including any added to...

  10. 7 CFR 3201.13 - Diesel fuel additives.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Diesel fuel additives. 3201.13 Section 3201.13... Designated Items § 3201.13 Diesel fuel additives. (a) Definition. (1) Any substance, other than one composed solely of carbon and/or hydrogen, that is intentionally added to diesel fuel (including any added to...

  11. 43 CFR 4110.4-1 - Additional land acreage.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Additional land acreage. 4110.4-1 Section 4110.4-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Qualifications and Preference § 4110.4-1 Additional land acreage. When lands outside designated allotments...

  12. 17 CFR 38.201 - Additional sources for compliance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Additional sources for compliance. 38.201 Section 38.201 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION DESIGNATED CONTRACT MARKETS Contracts Not Readily Subject to Manipulation § 38.201 Additional sources...

  13. 17 CFR 38.201 - Additional sources for compliance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Additional sources for compliance. 38.201 Section 38.201 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION DESIGNATED CONTRACT MARKETS Contracts Not Readily Subject to Manipulation § 38.201 Additional sources...

  14. Modeling of additive manufacturing processes for metals: Challenges and opportunities

    DOE PAGES

    Francois, Marianne M.; Sun, Amy; King, Wayne E.; ...

    2017-01-09

    Here, with the technology being developed to manufacture metallic parts using increasingly advanced additive manufacturing processes, a new era has opened up for designing novel structural materials, from designing shapes and complex geometries to controlling the microstructure (alloy composition and morphology). The material properties used within specific structural components are also designable in order to meet specific performance requirements that are not imaginable with traditional metal forming and machining (subtractive) techniques.

  15. Depression and Pain: Independent and Additive Relationships to Anger Expression

    DTIC Science & Technology

    2013-10-01

    Naval Health Research Center Depression and Pain : Independent and Additive Relationships to Anger Expression Marcus K. Taylor Gerald E...AND SUBTITLE Depression and Pain : Independent and Additive Relationships to Anger Expression 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...expression are understudied. OBJECTIVE: This study was designed to examine the independent and additive relationships of depression and pain to anger

  16. Application of Additively Manufactured Components in Rocket Engine Turbopumps

    NASA Technical Reports Server (NTRS)

    Calvert, Marty, Jr.; Hanks, Andrew; Schmauch, Preston; Delessio, Steve

    2015-01-01

    The use of additive manufacturing technology has the potential to revolutionize the development of turbopump components in liquid rocket engines. When designing turbomachinery with the additive process there are several benefits and risks that are leveraged relative to a traditional development cycle. This topic explores the details and development of a 90,000 RPM Liquid Hydrogen Turbopump from which 90% of the parts were derived from the additive process. This turbopump was designed, developed and will be tested later this year at Marshall Space Flight Center.

  17. Additively manufactured porous tantalum implants.

    PubMed

    Wauthle, Ruben; van der Stok, Johan; Amin Yavari, Saber; Van Humbeeck, Jan; Kruth, Jean-Pierre; Zadpoor, Amir Abbas; Weinans, Harrie; Mulier, Michiel; Schrooten, Jan

    2015-03-01

    The medical device industry's interest in open porous, metallic biomaterials has increased in response to additive manufacturing techniques enabling the production of complex shapes that cannot be produced with conventional techniques. Tantalum is an important metal for medical devices because of its good biocompatibility. In this study selective laser melting technology was used for the first time to manufacture highly porous pure tantalum implants with fully interconnected open pores. The architecture of the porous structure in combination with the material properties of tantalum result in mechanical properties close to those of human bone and allow for bone ingrowth. The bone regeneration performance of the porous tantalum was evaluated in vivo using an orthotopic load-bearing bone defect model in the rat femur. After 12 weeks, substantial bone ingrowth, good quality of the regenerated bone and a strong, functional implant-bone interface connection were observed. Compared to identical porous Ti-6Al-4V structures, laser-melted tantalum shows excellent osteoconductive properties, has a higher normalized fatigue strength and allows for more plastic deformation due to its high ductility. It is therefore concluded that this is a first step towards a new generation of open porous tantalum implants manufactured using selective laser melting.

  18. Additive Transforms Paint into Insulation

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Tech Traders Inc. sought assistance developing low-cost, highly effective coatings and paints that created useful thermal reflectance and were safe and non-toxic. In cooperation with a group of engineers at Kennedy Space Center., Tech Traders created Insuladd, a powder additive made up of microscopic, inert gas-filled, ceramic microspheres that can be mixed into ordinary interior or exterior paint, allowing the paint to act like a layer of insulation. When the paint dries, this forms a radiant heat barrier, turning the ordinary house paint into heat-reflecting thermal paint. According to Tech Traders, the product works with all types of paints and coatings and will not change the coverage rate, application, or adhesion of the paint. Other useful applications include feed storage silos to help prevent feed spoilage, poultry hatcheries to reduce the summer heat and winter cold effects, and on military vehicles and ships. Tech Traders has continued its connection to the aerospace community by recently providing Lockheed Martin Corporation with one of its thermal products for use on the F-22 Raptor.

  19. Sustainability Characterization for Additive Manufacturing

    PubMed Central

    Mani, Mahesh; Lyons, Kevin W; Gupta, SK

    2014-01-01

    Additive manufacturing (AM) has the potential to create geometrically complex parts that require a high degree of customization, using less material and producing less waste. Recent studies have shown that AM can be an economically viable option for use by the industry, yet there are some inherent challenges associated with AM for wider acceptance. The lack of standards in AM impedes its use for parts production since industries primarily depend on established standards in processes and material selection to ensure the consistency and quality. Inability to compare AM performance against traditional manufacturing methods can be a barrier for implementing AM processes. AM process sustainability has become a driver due to growing environmental concerns for manufacturing. This has reinforced the importance to understand and characterize AM processes for sustainability. Process characterization for sustainability will help close the gaps for comparing AM performance to traditional manufacturing methods. Based on a literature review, this paper first examines the potential environmental impacts of AM. A methodology for sustainability characterization of AM is then proposed to serve as a resource for the community to benchmark AM processes for sustainability. Next, research perspectives are discussed along with relevant standardization efforts. PMID:26601038

  20. Sustainability Characterization for Additive Manufacturing.

    PubMed

    Mani, Mahesh; Lyons, Kevin W; Gupta, S K

    2014-01-01

    Additive manufacturing (AM) has the potential to create geometrically complex parts that require a high degree of customization, using less material and producing less waste. Recent studies have shown that AM can be an economically viable option for use by the industry, yet there are some inherent challenges associated with AM for wider acceptance. The lack of standards in AM impedes its use for parts production since industries primarily depend on established standards in processes and material selection to ensure the consistency and quality. Inability to compare AM performance against traditional manufacturing methods can be a barrier for implementing AM processes. AM process sustainability has become a driver due to growing environmental concerns for manufacturing. This has reinforced the importance to understand and characterize AM processes for sustainability. Process characterization for sustainability will help close the gaps for comparing AM performance to traditional manufacturing methods. Based on a literature review, this paper first examines the potential environmental impacts of AM. A methodology for sustainability characterization of AM is then proposed to serve as a resource for the community to benchmark AM processes for sustainability. Next, research perspectives are discussed along with relevant standardization efforts.

  1. Dynamics of ultrasonic additive manufacturing.

    PubMed

    Hehr, Adam; Dapino, Marcelo J

    2017-01-01

    Ultrasonic additive manufacturing (UAM) is a solid-state technology for joining similar and dissimilar metal foils near room temperature by scrubbing them together with ultrasonic vibrations under pressure. Structural dynamics of the welding assembly and work piece influence how energy is transferred during the process and ultimately, part quality. To understand the effect of structural dynamics during UAM, a linear time-invariant model is proposed to relate the inputs of shear force and electric current to resultant welder velocity and voltage. Measured frequency response and operating performance of the welder under no load is used to identify model parameters. Using this model and in-situ measurements, shear force and welder efficiency are estimated to be near 2000N and 80% when welding Al 6061-H18 weld foil, respectively. Shear force and welder efficiency have never been estimated before in UAM. The influence of processing conditions, i.e., welder amplitude, normal force, and weld speed, on shear force and welder efficiency are investigated. Welder velocity was found to strongly influence the shear force magnitude and efficiency while normal force and weld speed showed little to no influence. The proposed model is used to describe high frequency harmonic content in the velocity response of the welder during welding operations and coupling of the UAM build with the welder.

  2. Dimensionless numbers in additive manufacturing

    NASA Astrophysics Data System (ADS)

    Mukherjee, T.; Manvatkar, V.; De, A.; DebRoy, T.

    2017-02-01

    The effects of many process variables and alloy properties on the structure and properties of additively manufactured parts are examined using four dimensionless numbers. The structure and properties of components made from 316 Stainless steel, Ti-6Al-4V, and Inconel 718 powders for various dimensionless heat inputs, Peclet numbers, Marangoni numbers, and Fourier numbers are studied. Temperature fields, cooling rates, solidification parameters, lack of fusion defects, and thermal strains are examined using a well-tested three-dimensional transient heat transfer and fluid flow model. The results show that lack of fusion defects in the fabricated parts can be minimized by strengthening interlayer bonding using high values of dimensionless heat input. The formation of harmful intermetallics such as laves phases in Inconel 718 can be suppressed using low heat input that results in a small molten pool, a steep temperature gradient, and a fast cooling rate. Improved interlayer bonding can be achieved at high Marangoni numbers, which results in vigorous circulation of liquid metal, larger pool dimensions, and greater depth of penetration. A high Fourier number ensures rapid cooling, low thermal distortion, and a high ratio of temperature gradient to the solidification growth rate with a greater tendency of plane front solidification.

  3. Children's understanding of additive concepts.

    PubMed

    Robinson, Katherine M; Dubé, Adam K; Beatch, Jacqueline-Ann

    2017-04-01

    Most research on children's arithmetic concepts is based on one concept at a time, limiting the conclusions that can be made about how children's conceptual knowledge of arithmetic develops. This study examined six arithmetic concepts (identity, negation, commutativity, equivalence, inversion, and addition and subtraction associativity) in Grades 3, 4, and 5. Identity (a-0=a) and negation (a-a=0) were well understood, followed by moderate understanding of commutativity (a+b=b+a) and inversion (a+b-b=a), with weak understanding of equivalence (a+b+c=a+[b+c]) and associativity (a+b-c=[b-c]+a). Understanding increased across grade only for commutativity and equivalence. Four clusters were found: The Weak Concept cluster understood only identity and negation; the Two-Term Concept cluster also understood commutativity; the Inversion Concept cluster understood identity, negation, and inversion; and the Strong Concept cluster had the strongest understanding of all of the concepts. Grade 3 students tended to be in the Weak and Inversion Concept clusters, Grade 4 students were equally likely to be in any of the clusters, and Grade 5 students were most likely to be in the Two-Term and Strong Concept clusters. The findings of this study highlight that conclusions about the development of arithmetic concepts are highly dependent on which concepts are being assessed and underscore the need for multiple concepts to be investigated at the same time.

  4. Current status of additive solutions for platelets.

    PubMed

    Alhumaidan, Hiba; Sweeney, Joseph

    2012-01-01

    The storage of platelets in additive solution (PAS) had lagged behind red cell concentrates, especially in North America. The partial or complete removal of anticoagulated plasma and storage of platelet concentrates in AS presents many advantages. The PAS can be formulated to optimize aerobic metabolism or decrease platelet activation, thus abrogating the platelet storage lesion and potentially improving in vivo viability. Plasma removal has been shown to reduce allergic reactions and the plasma harvested could contribute to the available plasma pool for transfusion or fractionation. PAS coupled to pathogen reduction technology results in a platelet product of equivalent hemostatic efficacy to conventionally stored platelets. Given the above, the likely future direction of platelet storage will be in new generation designer PAS with an extended shelf life and a superior safety profile to plasma stored platelets. J. Clin. Apheresis, 2012. © 2012 Wiley Periodicals, Inc.

  5. Additive manufacturing of biologically-inspired materials.

    PubMed

    Studart, André R

    2016-01-21

    Additive manufacturing (AM) technologies offer an attractive pathway towards the fabrication of functional materials featuring complex heterogeneous architectures inspired by biological systems. In this paper, recent research on the use of AM approaches to program the local chemical composition, structure and properties of biologically-inspired materials is reviewed. A variety of structural motifs found in biological composites have been successfully emulated in synthetic systems using inkjet-based, direct-writing, stereolithography and slip casting technologies. The replication in synthetic systems of design principles underlying such structural motifs has enabled the fabrication of lightweight cellular materials, strong and tough composites, soft robots and autonomously shaping structures with unprecedented properties and functionalities. Pushing the current limits of AM technologies in future research should bring us closer to the manufacturing capabilities of living organisms, opening the way for the digital fabrication of advanced materials with superior performance, lower environmental impact and new functionalities.

  6. Additives In Meat and Poultry Products

    MedlinePlus

    ... What is a food additive? What is a "direct" food additive? What is an 'indirect" food additive? ... convenience foods. [ Top of Page ] What is a “direct” food additive? According to the FDA, “Direct food ...

  7. Additively manufactured sub-periosteal jaw implants.

    PubMed

    Mommaerts, M Y

    2017-02-28

    Severe bone atrophy jeopardizes the success of endosseous implants. This technical note aims to present the innovative concept of additively manufactured sub-periosteal jaw implants (AMSJIs). Digital datasets of the patient's jaws and wax trial in occlusion are used to segment the bone and dental arches, for the design of a sub-periosteal frame and abutments in the optimal location related to the dental arch and for the design of the suprastructure. The implants and suprastructure are three-dimensionally (3D) printed in titanium alloy. The provisional denture is 3D-printed in polymer. AMSJIs offer an alternative approach for patients with extreme jaw bone atrophy. This report refers to the use of this technique for full maxillary rehabilitation, but partial defects in either jaw and extended post-resection defects may also be approached using the same technique. This customized, prosthesis-driven reverse-engineering approach avoids bone grafting and provides immediate functional restoration with one surgical session.

  8. Additive Manufacturing: Making Imagination the Major Limitation

    NASA Astrophysics Data System (ADS)

    Zhai, Yuwei; Lados, Diana A.; LaGoy, Jane L.

    2014-05-01

    Additive manufacturing (AM) refers to an advanced technology used for the fabrication of three-dimensional near-net-shaped functional components directly from computer models, using unit materials. The fundamentals and working principle of AM offer several advantages, including near-net-shape capabilities, superior design and geometrical flexibility, innovative multi-material fabrication, reduced tooling and fixturing, shorter cycle time for design and manufacturing, instant local production at a global scale, and material, energy, and cost efficiency. Well suiting the requests of modern manufacturing climate, AM is viewed as the new industrial revolution, making its way into a continuously increasing number of industries, such as aerospace, defense, automotive, medical, architecture, art, jewelry, and food. This overview was created to relate the historical evolution of the AM technology to its state-of-the-art developments and emerging applications. Generic thoughts on the microstructural characteristics, properties, and performance of AM-fabricated materials will also be discussed, primarily related to metallic materials. This write-up will introduce the general reader to specifics of the AM field vis-à-vis advantages and common techniques, materials and properties, current applications, and future opportunities.

  9. Additive manufacturing of glass for optical applications

    NASA Astrophysics Data System (ADS)

    Luo, Junjie; Gilbert, Luke J.; Bristow, Douglas A.; Landers, Robert G.; Goldstein, Jonathan T.; Urbas, Augustine M.; Kinzel, Edward C.

    2016-04-01

    Glasses including fused quartz have significant scientific and engineering applications including optics, communications, electronics, and hermetic seals. This paper investigates a filament fed process for Additive Manufacturing (AM) of fused quartz. Additive manufacturing has several potential benefits including increased design freedom, faster prototyping, and lower processing costs for small production volumes. However, current research in AM of glasses is limited and has focused on non-optical applications. Fused quartz is studied here because of its desirability for high-quality optics due to its high transmissivity and thermal stability. Fused quartz also has a higher working temperature than soda lime glass which poses a challenge for AM. In this work, fused quartz filaments are fed into a CO2 laser generated melt pool, smoothly depositing material onto the work piece. Single tracks are printed to explore the effects that different process parameters have on the morphology of printed fused quartz. A spectrometer is used to measure the thermal radiation incandescently emitted from the melt pool. Thin-walls are printed to study the effects of layer-to-layer height. Finally, a 3D fused quartz cube is printed using the newly acquired layer height and polished on each surface. The transmittance and index homogeneity of the polished cube are both measured. These results show that the filament fed process has the potential to print fused quartz with optical transparency and of index of refraction uniformity approaching bulk processed glass.

  10. Additive manufacturing of tools for lapping glass

    NASA Astrophysics Data System (ADS)

    Williams, Wesley B.

    2013-09-01

    Additive manufacturing technologies have the ability to directly produce parts with complex geometries without the need for secondary processes, tooling or fixtures. This ability was used to produce concave lapping tools with a VFlash 3D printer from 3D Systems. The lapping tools were first designed in Creo Parametric with a defined constant radius and radial groove pattern. The models were converted to stereolithography files which the VFlash used in building the parts, layer by layer, from a UV curable resin. The tools were rotated at 60 rpm and used with 120 grit and 220 grit silicon carbide lapping paste to lap 0.750" diameter fused silica workpieces. The samples developed a matte appearance on the lapped surface that started as a ring at the edge of the workpiece and expanded to the center. This indicated that as material was removed, the workpiece radius was beginning to match the tool radius. The workpieces were then cleaned and lapped on a second tool (with equivalent geometry) using a 3000 grit corundum aluminum oxide lapping paste, until a near specular surface was achieved. By using lapping tools that have been additively manufactured, fused silica workpieces can be lapped to approach a specified convex geometry. This approach may enable more rapid lapping of near net shape workpieces that minimize the material removal required by subsequent polishing. This research may also enable development of new lapping tool geometry and groove patterns for improved loose abrasive finishing.

  11. Polymer additives improve cementing in salt formations

    SciTech Connect

    Rae, P. )

    1988-12-05

    Recently, new anionic aromatic polymers (AAP's) have been identified that simultaneously impart to salt-rich cement slurries improved fluid-loss control and exceptional rheological properties. At the same time, these materials do not significantly extend the slurry-thickening time or impair the compressive strength development of the cement. Thus, the casing strings are protected in plastic zones very soon after completing the cement job. The cementing of wells penetrating massive salt formations has posed a number of problems over the years. Contributing to the problem was the fact that some cements displayed poor characteristics in saline environments, and that conventional additives were of limited use in these systems. Other additives, designed for salt water, were found to provide characteristics far from the optimum, while at the same time causing detrimental effects on other slurry properties, notably rheology, thickening time, and early compressive strength. In several areas, the presence of salt domes and massive evaporite sequences cause problems in the drilling, completion, and long-term production of oil and gas wells that penetrate these zones.

  12. Additional results for 'Sequential design approaches for bioequivalence studies with crossover designs'.

    PubMed

    Montague, Timothy H; Potvin, Diane; Diliberti, Charles E; Hauck, Walter W; Parr, Alan F; Schuirmann, Donald J

    2012-01-01

    In 2008, this group published a paper on approaches for two-stage crossover bioequivalence (BE) studies that allowed for the reestimation of the second-stage sample size based on the variance estimated from the first-stage results. The sequential methods considered used an assumed GMR of 0.95 as part of the method for determining power and sample size. This note adds results for an assumed GMR = 0.90. Two of the methods recommended for GMR = 0.95 in the earlier paper have some unacceptable increases in Type I error rate when the GMR is changed to 0.90. If a sponsor wants to assume 0.90 for the GMR, Method D is recommended. Copyright © 2011 John Wiley & Sons, Ltd.

  13. Implementation of Complexity Analyzing Based on Additional Effect

    NASA Astrophysics Data System (ADS)

    Zhang, Peng; Li, Na; Liang, Yanhong; Liu, Fang

    According to the Complexity Theory, there is complexity in the system when the functional requirement is not be satisfied. There are several study performances for Complexity Theory based on Axiomatic Design. However, they focus on reducing the complexity in their study and no one focus on method of analyzing the complexity in the system. Therefore, this paper put forth a method of analyzing the complexity which is sought to make up the deficiency of the researches. In order to discussing the method of analyzing the complexity based on additional effect, this paper put forth two concepts which are ideal effect and additional effect. The method of analyzing complexity based on additional effect combines Complexity Theory with Theory of Inventive Problem Solving (TRIZ). It is helpful for designers to analyze the complexity by using additional effect. A case study shows the application of the process.

  14. Overview of Food Ingredients, Additives and Colors

    MedlinePlus

    ... pesticides where other legal premarket approval requirements apply. Direct food additives are those that are added to ... and other foods to add texture -- is a direct additive. Most direct additives are identified on the ...

  15. Uniform Additivity in Classical and Quantum Information

    NASA Astrophysics Data System (ADS)

    Cross, Andrew; Li, Ke; Smith, Graeme

    2017-01-01

    Information theory quantifies the optimal rates of resource interconversions, usually in terms of entropies. However, nonadditivity often makes evaluating entropic formulas intractable. In a few auspicious cases, additivity allows a full characterization of optimal rates. We study uniform additivity of formulas, which is easily evaluated and captures all known additive quantum formulas. Our complete characterization of uniform additivity exposes an intriguing new additive quantity and identifies a remarkable coincidence—the classical and quantum uniformly additive functions with one auxiliary variable are identical.

  16. Transformation of Breast Reconstruction via Additive Biomanufacturing

    PubMed Central

    Chhaya, Mohit P.; Balmayor, Elizabeth R.; Hutmacher, Dietmar W.; Schantz, Jan-Thorsten

    2016-01-01

    Adipose tissue engineering offers a promising alternative to current breast reconstruction options. However, the conventional approach of using a scaffold in combination with adipose-derived precursor cells poses several problems in terms of scalability and hence clinical feasibility. Following the body-as-a-bioreactor approach, this study proposes a unique concept of delayed fat injection into an additive biomanufactured and custom-made scaffold. Three study groups were evaluated: Empty scaffold, Scaffold containing 4 cm3 lipoaspirate and Empty scaffold +2-week prevascularisation period. In group 3, of prevascularisation, 4 cm3 of lipoaspirate was injected into scaffolds after 2 weeks. Using a well-characterised additive biomanufacturing technology platform, patient-specific scaffolds made of medical-grade-polycaprolactone were designed and fabricated. Scaffolds were implanted in subglandular pockets in immunocompetent minipigs (n = 4) for 24-weeks. Angiogenesis and adipose tissue regeneration were observed in all constructs. Histological evaluation showed that the prevascularisation + lipoaspirate group had the highest relative area of adipose tissue (47.32% ± 4.12) which was significantly higher than both lipoaspirate-only (39.67% ± 2.04) and empty control group (8.31% ± 8.94) and similar to native breast tissue (44.97% ± 14.12). This large preclinical animal study provides proof-of-principle that the clinically applicable prevascularisation and delayed fat-injection techniques can be used for regeneration of large volumes of adipose tissue. PMID:27301425

  17. Feasibility and Testing of Additive Manufactured Components

    SciTech Connect

    Dehoff, Ryan R.; Hummelt, Ed; Solovyeva, Lyudmila

    2016-09-01

    This project focused on demonstrating the ability to fabricate two parts with different geometry: an arc flash interrupter and a hydraulic manifold. Eaton Corporation provided ORNL solid models, information related to tolerances and sensitive parameters of the parts and provided testing and evaluation. ORNL successfully manufactured both components, provided cost models of the manufacturing (materials, labor, time and post processing) and delivered test components for Eaton evaluation. The arc flash suppressor was fabricated using the Renishaw laser powder bed technology in CoCrMo while the manifold was produced from Ti-6Al-4V using the Arcam electron beam melting technology. These manufacturing techniques were selected based on the design and geometrical tolerances required. A full-scale manifold was produced on the Arcam A2 system (nearly 12 inches tall). A portion of the manifold was also produced in the Arcam Q10 system. Although a full scale manifold could not be produced in the system, a full scale manifold is expected to have similar material properties, geometric accuracy, and surface finish as could be fabricated on an Arcam Q20 system that is capable of producing four full scale manifolds in a production environment. In addition to the manifold, mechanical test specimens, geometric tolerance artifacts, and microstructure samples were produced alongside the manifold. The development and demonstration of these two key components helped Eaton understand the impact additive manufacturing can have on many of their existing products. By working within the MDF and leveraging ORNL’s manufacturing and characterization capabilities, the work will ensure the rapid insertion and commercialization of this technology.

  18. 16 CFR 1102.16 - Additional information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Content Requirements § 1102.16 Additional... in the Database any additional information it determines to be in the public interest,...

  19. 16 CFR 1102.16 - Additional information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Content Requirements § 1102.16 Additional... in the Database any additional information it determines to be in the public interest,...

  20. 16 CFR 1102.16 - Additional information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Content Requirements § 1102.16 Additional... in the Database any additional information it determines to be in the public interest,...

  1. 40 CFR 262.43 - Additional reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.43 Additional... require generators to furnish additional reports concerning the quantities and disposition of...

  2. 40 CFR 262.43 - Additional reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.43 Additional... require generators to furnish additional reports concerning the quantities and disposition of...

  3. 40 CFR 262.43 - Additional reporting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.43 Additional... require generators to furnish additional reports concerning the quantities and disposition of...

  4. 40 CFR 262.43 - Additional reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.43 Additional... require generators to furnish additional reports concerning the quantities and disposition of...

  5. 40 CFR 262.43 - Additional reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.43 Additional... require generators to furnish additional reports concerning the quantities and disposition of...

  6. Qualitative Reasoning for Additional Die Casting Applications

    SciTech Connect

    R. Allen Miller; Dehua Cui; Yuming Ma

    2003-05-28

    If manufacturing incompatibility of a product can be evaluated at the early product design stage, the designers can modify their design to reduce the effect of potential manufacturing problems. This will result in fewer manufacturing problems, less redsign, less expensive tooling, lower cost, better quality, and shorter development time. For a given design, geometric reasoning can predict qualitatively the behaviors of a physical manufacturing process by representing and reasoning with incomplete knowledge of the physical phenomena. It integrates a design with manufacturing processes to help designers simultaneously consider design goals and manufacturing constraints during the early design stage. The geometric reasoning approach can encourage design engineers to qualitatively evaluate the compatibility of their design with manufacturing limitations and requirements.

  7. IN718 Additive Manufacturing Properties and Influences

    NASA Technical Reports Server (NTRS)

    Lambert, Dennis M.

    2015-01-01

    The results of tensile, fracture, and fatigue testing of IN718 coupons produced using the selective laser melting (SLM) additive manufacturing technique are presented. The data have been "sanitized" to remove the numerical values, although certain references to material standards are provided. This document provides some knowledge of the effect of variation of controlled build parameters used in the SLM process, a snapshot of the capabilities of SLM in industry at present, and shares some of the lessons learned along the way. For the build parameter characterization, the parameters were varied over a range that was centered about the machine manufacturer's recommended value, and in each case they were varied individually, although some co-variance of those parameters would be expected. Tensile, fracture, and high-cycle fatigue properties equivalent to wrought IN718 are achievable with SLM-produced IN718. Build and post-build processes need to be determined and then controlled to established limits to accomplish this. It is recommended that a multi-variable evaluation, e.g., design-of experiment (DOE), of the build parameters be performed to better evaluate the co-variance of the parameters.

  8. IN718 Additive Manufacturing Properties and Influences

    NASA Technical Reports Server (NTRS)

    Lambert, Dennis M.

    2015-01-01

    The results of tensile, fracture, and fatigue testing of IN718 coupons produced using the selective laser melting (SLM) additive manufacturing technique are presented. The data has been "generalized" to remove the numerical values, although certain references to material standards are provided. This document provides some knowledge of the effect of variation of controlled build parameters used in the SLM process, a snapshot of the capabilities of SLM in industry at present, and shares some of the lessons learned along the way. For the build parameter characterization, the parameters were varied over a range about the machine manufacturer's recommended value, and in each case they were varied individually, although some co-variance of those parameters would be expected. SLM-produced IN718, tensile, fracture, and high-cycle fatigue properties equivalent to wrought IN718 are achievable. Build and post-build processes need to be determined and then controlled to established limits to accomplish this. It is recommended that a multi-variable evaluation, e.g., design-of-experiment (DOE), of the build parameters be performed to better evaluate the co-variance of the parameters.

  9. Computed tomography characterisation of additive manufacturing materials.

    PubMed

    Bibb, Richard; Thompson, Darren; Winder, John

    2011-06-01

    Additive manufacturing, covering processes frequently referred to as rapid prototyping and rapid manufacturing, provides new opportunities in the manufacture of highly complex and custom-fitting medical devices and products. Whilst many medical applications of AM have been explored and physical properties of the resulting parts have been studied, the characterisation of AM materials in computed tomography has not been explored. The aim of this study was to determine the CT number of commonly used AM materials. There are many potential applications of the information resulting from this study in the design and manufacture of wearable medical devices, implants, prostheses and medical imaging test phantoms. A selection of 19 AM material samples were CT scanned and the resultant images analysed to ascertain the materials' CT number and appearance in the images. It was found that some AM materials have CT numbers very similar to human tissues, FDM, SLA and SLS produce samples that appear uniform on CT images and that 3D printed materials show a variation in internal structure.

  10. 14 CFR 1274.917 - Additional funds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Additional funds. 1274.917 Section 1274.917... FIRMS Other Provisions and Special Conditions § 1274.917 Additional funds. Additional Funds July 2002... under the terms of this cooperative agreement. NASA is under no obligation to provide additional...

  11. Novel fundus camera design

    NASA Astrophysics Data System (ADS)

    Dehoog, Edward A.

    A fundus camera a complex optical system that makes use of the principle of reflex free indirect ophthalmoscopy to image the retina. Despite being in existence as early as 1900's, little has changed in the design of a fundus camera and there is minimal information about the design principles utilized. Parameters and specifications involved in the design of fundus camera are determined and their affect on system performance are discussed. Fundus cameras incorporating different design methods are modeled and a performance evaluation based on design parameters is used to determine the effectiveness of each design strategy. By determining the design principles involved in the fundus camera, new cameras can be designed to include specific imaging modalities such as optical coherence tomography, imaging spectroscopy and imaging polarimetry to gather additional information about properties and structure of the retina. Design principles utilized to incorporate such modalities into fundus camera systems are discussed. Design, implementation and testing of a snapshot polarimeter fundus camera are demonstrated.

  12. Oblivious Transfer from the Additive White Gaussian Noise Channel

    NASA Astrophysics Data System (ADS)

    Isaka, Motohiko

    We consider the use of the additive white Gaussian noise channel to achieve information theoretically secure oblivious transfer. A protocol for this primitive that ensures the correctness and privacy for players is presented together with the signal design. We also study the information theoretic efficiency of the protocol, and some more practical issues where the parameter of the channel is unknown to the players.

  13. 23 CFR 658.11 - Additions, deletions, exceptions, and restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    .... Changed conditions or additional information may require the deletion of a designated route or a portion...? Specifically describe lane widths, sight distance, severity and length of grades, horizontal curvature... specific travel lanes of multi-lane facilities, construction zones, adverse weather conditions...

  14. 23 CFR 658.11 - Additions, deletions, exceptions, and restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... Changed conditions or additional information may require the deletion of a designated route or a portion...? Specifically describe lane widths, sight distance, severity and length of grades, horizontal curvature... specific travel lanes of multi-lane facilities, construction zones, adverse weather conditions...

  15. 23 CFR 658.11 - Additions, deletions, exceptions, and restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... Changed conditions or additional information may require the deletion of a designated route or a portion...? Specifically describe lane widths, sight distance, severity and length of grades, horizontal curvature... specific travel lanes of multi-lane facilities, construction zones, adverse weather conditions...

  16. 23 CFR 658.11 - Additions, deletions, exceptions, and restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    .... Changed conditions or additional information may require the deletion of a designated route or a portion...? Specifically describe lane widths, sight distance, severity and length of grades, horizontal curvature... specific travel lanes of multi-lane facilities, construction zones, adverse weather conditions...

  17. Teaching Children about the Inverse Relation between Addition and Subtraction

    ERIC Educational Resources Information Center

    Nunes, Terezinha; Bryant, Peter; Hallett, Darcy; Bell, Daniel; Evans, Deborah

    2009-01-01

    Two intervention studies are described. Both were designed to study the effects of teaching children about the inverse relation between addition and subtraction. The interventions were successful with 8-year-old children in Study 1 and to a limited extent with 5-year-old children in Study 2. In Study 1 teaching children about inversion increased…

  18. Additive Biomanufacturing: An Advanced Approach for Periodontal Tissue Regeneration.

    PubMed

    Carter, Sarah-Sophia D; Costa, Pedro F; Vaquette, Cedryck; Ivanovski, Saso; Hutmacher, Dietmar W; Malda, Jos

    2017-01-01

    Periodontitis is defined as a chronic inflammatory condition, characterized by destruction of the periodontium, composed of hard (i.e. alveolar bone and cementum) and soft tissues (i.e. gingiva and periodontal ligament) surrounding and supporting the teeth. In severe cases, reduced periodontal support can lead to tooth loss, which requires tissue augmentation or procedures that initiate a repair, yet ideally a regenerative response. However, mimicking the three-dimensional complexity and functional integration of the different tissue components via scaffold- and/or matrix-based guided tissue engineering represents a great challenge. Additive biomanufacturing, a manufacturing method in which objects are designed and fabricated in a layer-by-layer manner, has allowed a paradigm shift in the current manufacturing of medical devices and implants. This shift from design-to-manufacture to manufacture-to-design, seen from a translational research point of view, provides the biomedical engineering and periodontology communities a technology with the potential to achieve tissue regeneration instead of repair. In this review, the focus is put on additively biomanufactured scaffolds for periodontal applications. Besides a general overview of the concept of additive biomanufacturing within this field, different developed scaffold designs are described. To conclude, future directions regarding advanced biomaterials and additive biomanufacturing technologies for applications in regenerative periodontology are highlighted.

  19. Recent Additions to the General College Career Development Program Offerings.

    ERIC Educational Resources Information Center

    Hixson, Bruce, Ed.

    1981-01-01

    Recent additions to the career development offerings at the University of Minnesota's General College are described. The aviation training program, which is described by Thomas Brothen, is designed to prepare students for licensure testing through the Federal Aviation Administration. Background information on aviation training at the University of…

  20. 49 CFR 192.171 - Compressor stations: Additional safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Compressor stations: Additional safety equipment...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design...

  1. 49 CFR 192.171 - Compressor stations: Additional safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Compressor stations: Additional safety equipment...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design...

  2. 49 CFR 192.171 - Compressor stations: Additional safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Compressor stations: Additional safety equipment...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design...

  3. 10 CFR 2.1004 - Amendments and additions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Waste at a Geologic Repository § 2.1004 Amendments and additions. Any document that has not been... time is approved by the Pre-License Application Presiding Officer or the Presiding Officer designated for the high-level waste proceeding. The time allowed under this paragraph will be stayed...

  4. 29 CFR 1602.37 - Additional reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AND REPORTING REQUIREMENTS UNDER TITLE VII, THE ADA AND GINA State and Local Government Information Report § 1602.37 Additional reporting requirements. The Commission reserves the right to require reports, other than that designated as the “State and Local Government Information Report EEO-4,” about...

  5. 29 CFR 1602.37 - Additional reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AND REPORTING REQUIREMENTS UNDER TITLE VII, THE ADA AND GINA State and Local Government Information Report § 1602.37 Additional reporting requirements. The Commission reserves the right to require reports, other than that designated as the “State and Local Government Information Report EEO-4,” about...

  6. 29 CFR 1602.37 - Additional reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND REPORTING REQUIREMENTS UNDER TITLE VII, THE ADA AND GINA State and Local Government Information Report § 1602.37 Additional reporting requirements. The Commission reserves the right to require reports, other than that designated as the “State and Local Government Information Report EEO-4,” about...

  7. 29 CFR 1602.37 - Additional reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AND REPORTING REQUIREMENTS UNDER TITLE VII, THE ADA AND GINA State and Local Government Information Report § 1602.37 Additional reporting requirements. The Commission reserves the right to require reports, other than that designated as the “State and Local Government Information Report EEO-4,” about...

  8. 29 CFR 1602.37 - Additional reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND REPORTING REQUIREMENTS UNDER TITLE VII, THE ADA AND GINA State and Local Government Information Report § 1602.37 Additional reporting requirements. The Commission reserves the right to require reports, other than that designated as the “State and Local Government Information Report EEO-4,” about...

  9. 19 CFR 141.37 - Additional requirements for nonresident corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... corporations. 141.37 Section 141.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Additional requirements for nonresident corporations. If a nonresident corporation has not qualified to... authority of the grantor designated to execute the power of attorney on behalf of the corporation....

  10. Improving designer productivity

    NASA Technical Reports Server (NTRS)

    Hill, Gary C.

    1992-01-01

    Designer and design team productivity improves with skill, experience, and the tools available. The design process involves numerous trials and errors, analyses, refinements, and addition of details. Computerized tools have greatly speeded the analysis, and now new theories and methods, emerging under the label Artificial Intelligence (AI), are being used to automate skill and experience. These tools improve designer productivity by capturing experience, emulating recognized skillful designers, and making the essence of complex programs easier to grasp. This paper outlines the aircraft design process in today's technology and business climate, presenting some of the challenges ahead and some of the promising AI methods for meeting those challenges.

  11. Additive Construction using Basalt Regolith Fines

    NASA Technical Reports Server (NTRS)

    Mueller, Robert P.; Sibille, Laurent; Hintze, Paul E.; Lippitt, Thomas C.; Mantovani, James G.; Nugent, Matthew W.; Townsend, Ivan I.

    2014-01-01

    Planetary surfaces are often covered in regolith (crushed rock), whose geologic origin is largely basalt. The lunar surface is made of small-particulate regolith and areas of boulders located in the vicinity of craters. Regolith composition also varies with location, reflecting the local bedrock geology and the nature and efficiency of the micrometeorite-impact processes. In the lowland mare areas (suitable for habitation), the regolith is composed of small granules (20 - 100 microns average size) of mare basalt and volcanic glass. Impacting micrometeorites may cause local melting, and the formation of larger glassy particles, and this regolith may contain 10-80% glass. Studies of lunar regolith are traditionally conducted with lunar regolith simulant (reconstructed soil with compositions patterned after the lunar samples returned by Apollo). The NASA Kennedy Space Center (KSC) Granular Mechanics & Regolith Operations (GMRO) lab has identified a low fidelity but economical geo-technical simulant designated as Black Point-1 (BP-1). It was found at the site of the Arizona Desert Research and Technology Studies (RATS) analog field test site at the Black Point lava flow in adjacent basalt quarry spoil mounds. This paper summarizes activities at KSC regarding the utilization of BP-1 basalt regolith and comparative work with lunar basalt simulant JSC-1A as a building material for robotic additive construction of large structures. In an effort to reduce the import or in-situ fabrication of binder additives, we focused this work on in-situ processing of regolith for construction in a single-step process after its excavation. High-temperature melting of regolith involves techniques used in glassmaking and casting (with melts of lower density and higher viscosity than those of metals), producing basaltic glass with high durability and low abrasive wear. Most Lunar simulants melt at temperatures above 1100 C, although melt processing of terrestrial regolith at 1500 C is not

  12. 40 CFR 79.21 - Information and assurances to be provided by the additive manufacturer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Additive... application for registration submitted by the manufacturer of a designated fuel additive shall include the..., percentage by weight, and method of analysis of each element in the additive are required provided,...

  13. ADHD Diet: Do Food Additives Cause Hyperactivity?

    MedlinePlus

    ... There's no solid evidence that food additives cause attention-deficit/hyperactivity disorder (ADHD). However, the topic of food additives and their possible effects is controversial. Some studies indicate that certain food ...

  14. Additive Manufacturing of Aerospace Propulsion Components

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.; Grady, Joseph E.; Carter, Robert

    2015-01-01

    The presentation will provide an overview of ongoing activities on additive manufacturing of aerospace propulsion components, which included rocket propulsion and gas turbine engines. Future opportunities on additive manufacturing of hybrid electric propulsion components will be discussed.

  15. 7 CFR 1944.686 - Additional grants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Additional grants. 1944.686 Section 1944.686...) PROGRAM REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants § 1944.686 Additional grants. An additional HPG grant may be made when the grantee has achieved or nearly achieved the goals established...

  16. 7 CFR 1944.545 - Additional grants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false Additional grants. 1944.545 Section 1944.545...) PROGRAM REGULATIONS (CONTINUED) HOUSING Technical and Supervisory Assistance Grants § 1944.545 Additional grants. An additional grant may be made to an applicant that has previously received a TSA grant and...

  17. 7 CFR 1944.545 - Additional grants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Additional grants. 1944.545 Section 1944.545...) PROGRAM REGULATIONS (CONTINUED) HOUSING Technical and Supervisory Assistance Grants § 1944.545 Additional grants. An additional grant may be made to an applicant that has previously received a TSA grant and...

  18. 7 CFR 1944.686 - Additional grants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false Additional grants. 1944.686 Section 1944.686...) PROGRAM REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants § 1944.686 Additional grants. An additional HPG grant may be made when the grantee has achieved or nearly achieved the goals established...

  19. 7 CFR 1944.545 - Additional grants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Additional grants. 1944.545 Section 1944.545...) PROGRAM REGULATIONS (CONTINUED) HOUSING Technical and Supervisory Assistance Grants § 1944.545 Additional grants. An additional grant may be made to an applicant that has previously received a TSA grant and...

  20. 10 CFR 55.7 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition...

  1. Polymeric Additives For Graphite/Epoxy Composites

    NASA Technical Reports Server (NTRS)

    Kourtides, D. A.; Nir, Z.

    1990-01-01

    Report describes experimental studies of properties of several graphite/epoxy composites containing polymeric additives as flexibilizing or toughening agents. Emphasizes effects of brominated polymeric additives (BPA's) with or without carboxy-terminated butadiene acrylonitrile rubber. Reviews effects of individual and combined additives on fracture toughnesses, environmental stabilities, hot/wet strengths, thermomechanical behaviors, and other mechanical properties of composites.

  2. 10 CFR 55.7 - Additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition...

  3. 14 CFR 27.927 - Additional tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Additional tests. 27.927 Section 27.927... STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.927 Additional tests. (a) Any additional dynamic, endurance, and operational tests, and vibratory investigations necessary to...

  4. 14 CFR 29.927 - Additional tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Additional tests. 29.927 Section 29.927... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.927 Additional tests. (a) Any additional dynamic, endurance, and operational tests, and vibratory investigations necessary to...

  5. 14 CFR 27.927 - Additional tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Additional tests. 27.927 Section 27.927... STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.927 Additional tests. (a) Any additional dynamic, endurance, and operational tests, and vibratory investigations necessary to...

  6. 14 CFR 27.927 - Additional tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Additional tests. 27.927 Section 27.927... STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.927 Additional tests. (a) Any additional dynamic, endurance, and operational tests, and vibratory investigations necessary to...

  7. 14 CFR 29.927 - Additional tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Additional tests. 29.927 Section 29.927... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.927 Additional tests. (a) Any additional dynamic, endurance, and operational tests, and vibratory investigations necessary to...

  8. 14 CFR 29.927 - Additional tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Additional tests. 29.927 Section 29.927... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.927 Additional tests. (a) Any additional dynamic, endurance, and operational tests, and vibratory investigations necessary to...

  9. 17 CFR 48.10 - Additional contracts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Additional contracts. 48.10...) REGISTRATION OF FOREIGN BOARDS OF TRADE § 48.10 Additional contracts. (a) Generally. A registered foreign board of trade that wishes to make an additional futures, option or swap contract available for trading...

  10. 17 CFR 48.10 - Additional contracts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Additional contracts. 48.10... FOREIGN BOARDS OF TRADE § 48.10 Additional contracts. (a) Generally. A registered foreign board of trade that wishes to make an additional futures, option or swap contract available for trading by...

  11. 12 CFR 615.5460 - Additional provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Additional provisions. 615.5460 Section 615.5460 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FUNDING AND FISCAL AFFAIRS, LOAN... Additional provisions. (a) Additional requirements. In any case or any class of cases arising under...

  12. 46 CFR 355.5 - Additional material.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Additional material. 355.5 Section 355.5 Shipping... STATES CITIZENSHIP § 355.5 Additional material. If additional material is determined to be essential to clarify or support the evidence of U.S. citizenship, such material shall be furnished by...

  13. 7 CFR 1944.545 - Additional grants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 13 2012-01-01 2012-01-01 false Additional grants. 1944.545 Section 1944.545...) PROGRAM REGULATIONS (CONTINUED) HOUSING Technical and Supervisory Assistance Grants § 1944.545 Additional grants. An additional grant may be made to an applicant that has previously received a TSA grant and...

  14. 7 CFR 1944.686 - Additional grants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 13 2012-01-01 2012-01-01 false Additional grants. 1944.686 Section 1944.686...) PROGRAM REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants § 1944.686 Additional grants. An additional HPG grant may be made when the grantee has achieved or nearly achieved the goals established...

  15. 7 CFR 1944.545 - Additional grants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Additional grants. 1944.545 Section 1944.545...) PROGRAM REGULATIONS (CONTINUED) HOUSING Technical and Supervisory Assistance Grants § 1944.545 Additional grants. An additional grant may be made to an applicant that has previously received a TSA grant and...

  16. 7 CFR 1944.686 - Additional grants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Additional grants. 1944.686 Section 1944.686...) PROGRAM REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants § 1944.686 Additional grants. An additional HPG grant may be made when the grantee has achieved or nearly achieved the goals established...

  17. 46 CFR 355.5 - Additional material.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Additional material. 355.5 Section 355.5 Shipping... STATES CITIZENSHIP § 355.5 Additional material. If additional material is determined to be essential to clarify or support the evidence of U.S. citizenship, such material shall be furnished by...

  18. 46 CFR 355.5 - Additional material.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Additional material. 355.5 Section 355.5 Shipping... STATES CITIZENSHIP § 355.5 Additional material. If additional material is determined to be essential to clarify or support the evidence of U.S. citizenship, such material shall be furnished by...

  19. 46 CFR 355.5 - Additional material.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Additional material. 355.5 Section 355.5 Shipping... STATES CITIZENSHIP § 355.5 Additional material. If additional material is determined to be essential to clarify or support the evidence of U.S. citizenship, such material shall be furnished by...

  20. 5 CFR 841.1006 - Additional provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Additional provisions. 841.1006 Section....1006 Additional provisions. These additional provisions are also binding on the State and OPM: (a) A... will issue an accounting. If the State finds this accounting unacceptable, it may then and only...