76 FR 23528 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... flood insurance premium rates for new buildings and the contents in those buildings. DATES: Comments are... premium rates for new buildings built after these elevations are made final, and for the contents in those buildings. Comments on any aspect of the Flood Insurance Study and FIRM, other than the proposed BFEs, will...

76 FR 13569 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

..., FEMA published in the Federal Register a proposed rule that included erroneous Base Flood Elevation... for the proposed BFE of 1,290 feet, referenced to the North American Vertical Datum of 1988, should... Vertical Datum of 1988, should have located the proposed BFE as being approximately 0.24 mile upstream of...

76 FR 14359 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

..., FEMA published in the Federal Register a proposed rule that included erroneous Base Flood Elevation... description for the proposed BFE of 1,032 feet, referenced to the North American Vertical Datum of 1988... description for the proposed BFE of 1,049 feet, referenced to the North American Vertical Datum of 1988...

76 FR 50443 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-15

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2011-0002; Internal Agency Docket No. FEMA-B-1196] Proposed Flood Elevation Determinations Correction In proposed rule document 2011-16640 appearing on pages 39063 through 39067 in the issue of Tuesday...

76 FR 12308 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2011-0002; Internal Agency Docket No. FEMA-B-1174] Proposed Flood Elevation Determinations Correction In proposed rule document 2011-2281 beginning on page 5769 in the issue of Wednesday, February 2...

75 FR 62057 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... buildings. Comments on any aspect of the Flood Insurance Study and FIRM, other than the proposed BFEs, will... State Highway 274. Duck Creek Approximately 925 feet None +458 Unincorporated Areas of downstream of...

75 FR 67317 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... buildings. Comments on any aspect of the Flood Insurance Study and FIRM, other than the proposed BFEs, will... Approximately 700 feet None +41 City of Brooksville, downstream of Duck Unincorporated Areas Pond Road (at...

17 CFR 240.14a-8 - Shareholder proposals.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Exchange Act of 1934 Regulation 14a: Solicitation of Proxies § 240.14a-8 Shareholder proposals. Link to an amendment published at 75 FR 56782, Sept. 16, 2010. Link to a delay published at 75 FR 64641, Oct. 20, 2010. Link to an amendment published at 76 FR 6045, Feb. 2, 2011. This section addresses when a company must...

76 FR 8965 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

... buildings. Comments on any aspect of the Flood Insurance Study and FIRM, other than the proposed BFEs, will.... Approximately 1,320 None +410 feet upstream of Uncle Duck Road. Hall Branch At the Shaws Creek None +426...

44 CFR 61.14 - Standard Flood Insurance Policy Interpretations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES § 61.14 Standard Flood Insurance Policy Interpretations. (a... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Standard Flood Insurance...

44 CFR 61.14 - Standard Flood Insurance Policy Interpretations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES § 61.14 Standard Flood Insurance Policy Interpretations. (a... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Standard Flood Insurance...

44 CFR 61.14 - Standard Flood Insurance Policy Interpretations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES § 61.14 Standard Flood Insurance Policy Interpretations. (a... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Standard Flood Insurance...

44 CFR 61.14 - Standard Flood Insurance Policy Interpretations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES § 61.14 Standard Flood Insurance Policy Interpretations. (a... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Standard Flood Insurance...

44 CFR 61.14 - Standard Flood Insurance Policy Interpretations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES § 61.14 Standard Flood Insurance Policy Interpretations. (a... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Standard Flood Insurance...

76 FR 46716 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

... rule published at 75 FR 31373, in the June 3, 2010, issue of the Federal Register, FEMA published a... Tributary, Unnamed Tributary Number 1, Unnamed Tributary Number 2, Unnamed Tributary Number 3, and Unnamed...: Federal Emergency Management Agency, DHS. ACTION: Proposed rule; correction. SUMMARY: On June 3, 2010...

77 FR 73396 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2010-0003; Internal Agency Docket No. FEMA-B-1089] Proposed Flood Elevation Determinations AGENCY.... ADDRESSES: You may submit comments, identified by Docket No. FEMA-B- 1089, to Luis Rodriguez, Chief...

77 FR 73398 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2010-0003; Internal Agency Docket No. FEMA-B-1085] Proposed Flood Elevation Determinations AGENCY..., identified by Docket No. FEMA-B- 1085, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...

77 FR 73393 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2010-0003; Internal Agency Docket No. FEMA-B-1085] Proposed Flood Elevation Determinations AGENCY..., identified by Docket No. FEMA-B- 1085, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...

76 FR 13571 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2008-0020; Internal Agency Docket No. FEMA-B-1072] Proposed Flood Elevation Determinations AGENCY... June 13, 2011. ADDRESSES: You may submit comments, identified by Docket No. FEMA-B- 1072, to Luis...

76 FR 26980 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

...-2010-0003; Internal Agency Docket No. FEMA-B-1155] Proposed Flood Elevation Determinations AGENCY... Lake Michigan and White Ditch in La Porte County, Indiana. The City of Michiana Shores should have been listed as the Town of Michiana Shores. DATES: Comments pertaining to the Lake Michigan and White Ditch...

78 FR 45944 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

...; Internal Agency Docket No. FEMA-B-1247] Proposed Flood Hazard Determinations AGENCY: Federal Emergency... at www.msc.fema.gov for comparison. You may submit comments, identified by Docket No. FEMA-B-1247, to...-4064 or (email) [email protected] ; or visit the FEMA Map Information eXchange (FMIX) online...

75 FR 47737 - Proposed Revocation of Colored Federal Airway G-4; AK

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-09

...-0453; Airspace Docket No. 10-AAL-14] RIN 2120-AA66 Proposed Revocation of Colored Federal Airway G-4... Register on June 8, 2010 (75 FR 32317). In that action, the FAA proposed to remove Federal Airway Green (G... NPRM proposing to remove Federal Airway G-4 (75 FR 32317), Docket No. FAA- 2010-0453. A review of...

75 FR 75666 - Advanced Placement (AP) Test Fee Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-06

... DEPARTMENT OF EDUCATION [CFDA No. 84.330B] Advanced Placement (AP) Test Fee Program AGENCY: Office... AP Test Fee fiscal year (FY) 2011 competition. SUMMARY: On September 1, 2010, we published in the Federal Register (75 FR 53681) a notice inviting applications for the AP Test Fee FY 2011 competition...

76 FR 8984 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

... buildings. Comments on any aspect of the Flood Insurance Study and FIRM, other than the proposed BFEs, will... Glacier Highway. At the Auke Bay ferry [caret]22 [caret]29 terminal. Duck Creek At the downstream side... [caret]52 upstream of Taku Boulevard. East Fork Duck Creek Approximately 150 feet [caret]31 [caret]34...

76 FR 32896 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... buildings. Comments on any aspect of the Flood Insurance Study and FIRM, other than the proposed BFEs, will... Creek confluence. At the downstream side +489 +491 of Oak Gate Lane. Long Branch (of Duck Creek) Bypass.. At the upstream side of +498 +490 City of Mesquite. the Long Branch (of Duck Creek) confluence...

76 FR 70403 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

... Flood Insurance Rate Map located at the community map repository (see below) for exact locations of all... Insurance Rate Map located at the community map repository (see below) for exact locations of all BFEs to be... Insurance Rate Map (FIRM) for the proposed BFEs for each community is available for inspection at the...

76 FR 26978 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... Insurance Rate Map located at the community map repository (see below) for exact locations of all BFEs to be... Insurance Rate Map located at the community map repository (see below) for exact locations of all BFEs to be... Flood Insurance Rate Map (FIRM) for the proposed BFEs for each community is available for inspection at...

77 FR 8842 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... DEPARTMENT OF DEFENSE Department of the Army [Docket ID USA-2008-0006] Proposed Collection... effort as a useful self-assessment, self-improvement, and benchmarking tool, while ensuring that data..., Department of Defense. [FR Doc. 2012-3506 Filed 2-14-12; 8:45 am] BILLING CODE 5001-06-P ...

76 FR 3596 - Proposed Flood Elevation Determinations for York County, Maine (All Jurisdictions)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

...-2008-0020; Internal Agency Docket No. FEMA-B-1066] Proposed Flood Elevation Determinations for York... notice of proposed rulemaking concerning proposed flood elevation determinations for York County, Maine...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration...

76 FR 13990 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-HA-0033] Proposed Collection; Comment Request AGENCY: Office of the Assistant Secretary of Defense for Health Affairs, DoD. ACTION... Officer, Department of Defense. [FR Doc. 2011-5910 Filed 3-14-11; 8:45 am] BILLING CODE 5001-06-P ...

76 FR 8986 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

... Main Street, Bloomfield, IN 47424. King County, Washington, and Incorporated Areas Black River... East Valley Road. Springbrook Creek At the upstream side of +19 +10 City of Kent, City of Black River... Assistance No. 97.022, ``Flood Insurance.'') Dated: February 7, 2011. Sandra K. Knight, Deputy Federal...

44 CFR 65.12 - Revision of flood insurance rate maps to reflect base flood elevations caused by proposed...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Revision of flood insurance rate maps to reflect base flood elevations caused by proposed encroachments. 65.12 Section 65.12... INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IDENTIFICATION AND MAPPING OF SPECIAL...

76 FR 62395 - Proposed Agency Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-07

... the agency's estimate of the burden of the proposed collection of information, including the validity... Delivery and Energy Reliability. [FR Doc. 2011-26061 Filed 10-6-11; 8:45 am] BILLING CODE 6450-01-P ...

77 FR 55787 - Proposed Flood Elevation Determinations for the City of Carson City, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

...-2011-0002; Internal Agency Docket No. FEMA-B-1233] Proposed Flood Elevation Determinations for the City of Carson City, NV AGENCY: Federal Emergency Management Agency, DHS. ACTION: Proposed rule... concerning proposed flood elevation determinations for the City of Carson City, Nevada. DATES: This...

AP1000{sup R} design robustness against extreme external events - Seismic, flooding, and aircraft crash

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfister, A.; Goossen, C.; Coogler, K.

2012-07-01

Both the International Atomic Energy Agency (IAEA) and the U.S. Nuclear Regulatory Commission (NRC) require existing and new nuclear power plants to conduct plant assessments to demonstrate the unit's ability to withstand external hazards. The events that occurred at the Fukushima-Dai-ichi nuclear power station demonstrated the importance of designing a nuclear power plant with the ability to protect the plant against extreme external hazards. The innovative design of the AP1000{sup R} nuclear power plant provides unparalleled protection against catastrophic external events which can lead to extensive infrastructure damage and place the plant in an extended abnormal situation. The AP1000 plantmore » is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance and safety. The plant's compact safety related footprint and protection provided by its robust nuclear island structures prevent significant damage to systems, structures, and components required to safely shutdown the plant and maintain core and spent fuel pool cooling and containment integrity following extreme external events. The AP1000 nuclear power plant has been extensively analyzed and reviewed to demonstrate that it's nuclear island design and plant layout provide protection against both design basis and extreme beyond design basis external hazards such as extreme seismic events, external flooding that exceeds the maximum probable flood limit, and malicious aircraft impact. The AP1000 nuclear power plant uses fail safe passive features to mitigate design basis accidents. The passive safety systems are designed to function without safety-grade support systems (such as AC power, component cooling water, service water, compressed air or HVAC). The plant has been designed to protect systems, structures, and components critical to placing the reactor in a safe shutdown condition within the steel containment

76 FR 46715 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

... table provided here represents the flooding sources, location of referenced elevations, effective and.... Specifically, it addresses the following flooding sources: Cabin Branch, Franklin Branch, Hall Creek, Little... Incorporated Areas'' addressed the following flooding sources: Cabin Branch, Franklin Branch, Little Patuxent...

77 FR 15664 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... table provided here represents the flooding sources, location of referenced elevations, and effective and modified elevations for the City of Cadiz, Kentucky. Specifically, it addresses the flooding... Cadiz, Kentucky'' addressed the flooding sources Little River (backwater effects from Lake Barkley) and...

77 FR 66790 - Proposed Flood Elevation Determinations for Madison County, AL and Incorporated Areas

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

...-2011-0002; Internal Agency Docket No. FEMA-B-1189] Proposed Flood Elevation Determinations for Madison... concerning proposed flood elevation determinations for Madison County, Alabama and Incorporated Areas. DATES... Mitigation Administration, Federal Emergency Management Agency, 500 C Street SW., Washington, DC 20472, (202...

76 FR 26981 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... table provided here represents the flooding sources, location of referenced elevations, effective and.... Specifically, it addresses the following flooding sources: Cache Creek, Cache Creek Left Bank Overflow, and... ``Unincorporated Areas of Yolo County, California'' addressed the flooding source Cache Creek Settling Basin. That...

76 FR 13570 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

.... The table provided here represents the flooding sources, location of referenced elevations, effective.... Specifically, it addresses the flooding source South Creek. DATES: Comments are to be submitted on or before... table, entitled ``Sanpete County, Utah, and Incorporated Areas'' addressed the flooding source South...

77 FR 50667 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... table provided here represents the flooding sources, location of referenced elevations, effective and...). Specifically, it addresses the flooding sources Fourmile Creek and Lake Erie. DATES: Comments are to be... Jurisdictions)'' addressed the flooding sources Fourmile Creek and Lake Erie. That table contained inaccurate...

78 FR 22221 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... table provided here represents the flooding sources, location of referenced elevations, effective and.... Specifically, it addresses the following flooding sources: Pea Branch and Reedy Branch. DATES: Comments are to... Areas'' did not address the flooding sources Pea Branch and Reedy Branch. That table omitted information...

77 FR 51745 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

.... Specifically, it addresses the following flooding sources: Back Creek, Big Elk Creek, Bohemia River, Chesapeake... Areas'' addressed the following flooding sources: Back Creek, Big Elk Creek, Bohemia River, Chesapeake... modified elevation in feet, and/or communities affected for the following flooding sources: Big Elk Creek...

78 FR 69703 - 10-Day Notice of Proposed Information Collection: Generic Customer Satisfaction Surveys; Physical...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5683-N-102] 10-Day Notice of Proposed Information Collection: Generic Customer Satisfaction Surveys; Physical Inspection Pilot Program...

78 FR 8089 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... flooding sources Big Run, Little Loyalsock Creek, Loyalsock Creek, and Muncy Creek. DATES: Comments are to..., Pennsylvania (All Jurisdictions)'' addressed the flooding sources Big Run, Little Loyalsock Creek, Loyalsock... Sullivan County, Pennsylvania (All Jurisdictions) Big Run At the Muncy Creek +968 +965 Township of Davidson...

77 FR 67324 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

...). Specifically, it addresses the flooding sources Big Run, Little Loyalsock Creek, Loyalsock Creek, and Muncy..., Pennsylvania (All Jurisdictions)'' addressed the flooding sources Big Run, Little Loyalsock Creek, Loyalsock... Sullivan County, Pennsylvania (All Jurisdictions) Big Run At the Muncy Creek +968 +965 Township of Davidson...

76 FR 12665 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-08

... Areas. Specifically, it addresses the following flooding sources: Hungry Hollow Gulch, Ice House Creek, Ice House Creek Tributary A, Riggs Gulch, Spearfish Creek, and Unnamed Tributary to Higgins Gulch... Incorporated Areas'' addressed the following flooding sources: Hungry Hollow Gulch, Ice House Creek, Ice House...

76 FR 26982 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

.... Specifically, it addresses the flooding source Licking River (Cave Run Lake). DATES: Comments are to be... Incorporated Areas,'' addressed the flooding source Licking River (Cave Run Lake). That table contained... River (Cave Run Lake)....... At the Buck Creek None +765 City of Frenchburg, confluence. Unincorporated...

76 FR 43968 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... qualify or remain qualified for participation in the National Flood Insurance Program (NFIP). In addition, these elevations, once finalized, will be used by insurance agents and others to calculate appropriate flood insurance premium rates for new buildings and the contents in those buildings. DATES: Comments are...

77 FR 50665 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... addresses the flooding sources Allegheny River, East Sandy Creek, and Sugar Creek. DATES: Comments are to be... Jurisdictions)'' addressed the flooding sources Allegheny River, East Sandy Creek, and Sugar Creek. That table...,000 None +961 feet upstream of the confluence with the Allegheny River. Sugar Creek Approximately 0.79...

78 FR 8177 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... insurance agents and others to calculate appropriate flood insurance premium rates for new buildings and the contents of those buildings. DATES: Comments are to be submitted on or before May 6, 2013. ADDRESSES: The... buildings built after the FIRM and FIS report become effective. The communities affected by the flood hazard...

76 FR 16722 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

..., Overflow Creek Tributary, Red Cut Slough, Red Cut Slough Tributary, Red Cut Slough Tributary 2, and Red Cut... flooding sources: Gum Creek Flooding Effects, Little Red River, Overflow Creek Tributary, Red Cut Slough, Red Cut Slough Tributary, Red Cut Slough Tributary 2, and Red Cut Slough Tributary A. In this notice...

75 FR 60758 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

... through the use of automated collection techniques or other forms of information technology. Proposed...'s ``Medication-Assisted Treatment for Opioid Addiction State Profiles.'' These publications will be..., Technology, and Operations. [FR Doc. 2010-24505 Filed 9-30-10; 8:45 am] BILLING CODE 4162-20-P ...

75 FR 81249 - Intent To Prepare a Supplemental Draft Environmental Impact Statement for a Proposed Flood Risk...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

... Draft Environmental Impact Statement for a Proposed Flood Risk Management Project on the Red River of... Study (EIS/FS) for a Proposed Fargo- Moorhead Flood Risk Management Project on the Red River of the North in Fargo, ND, and Moorhead, MN (Proposed Fargo-Moorhead Project). On May 5, 2009, the St. Paul...

46 CFR 62.35-10 - Flooding safety.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Flooding safety. 62.35-10 Section 62.35-10 Shipping... Requirements for Specific Types of Automated Vital Systems § 62.35-10 Flooding safety. (a) Automatic bilge.... (b) Remote controls for flooding safety equipment must remain functional under flooding conditions to...

46 CFR 62.35-10 - Flooding safety.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Flooding safety. 62.35-10 Section 62.35-10 Shipping... Requirements for Specific Types of Automated Vital Systems § 62.35-10 Flooding safety. (a) Automatic bilge.... (b) Remote controls for flooding safety equipment must remain functional under flooding conditions to...

46 CFR 62.35-10 - Flooding safety.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Flooding safety. 62.35-10 Section 62.35-10 Shipping... Requirements for Specific Types of Automated Vital Systems § 62.35-10 Flooding safety. (a) Automatic bilge.... (b) Remote controls for flooding safety equipment must remain functional under flooding conditions to...

46 CFR 62.35-10 - Flooding safety.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Flooding safety. 62.35-10 Section 62.35-10 Shipping... Requirements for Specific Types of Automated Vital Systems § 62.35-10 Flooding safety. (a) Automatic bilge.... (b) Remote controls for flooding safety equipment must remain functional under flooding conditions to...

46 CFR 62.35-10 - Flooding safety.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Flooding safety. 62.35-10 Section 62.35-10 Shipping... Requirements for Specific Types of Automated Vital Systems § 62.35-10 Flooding safety. (a) Automatic bilge.... (b) Remote controls for flooding safety equipment must remain functional under flooding conditions to...

44 CFR 65.14 - Remapping of areas for which local flood protection systems no longer provide base flood protection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... local flood protection systems no longer provide base flood protection. 65.14 Section 65.14 Emergency... § 65.14 Remapping of areas for which local flood protection systems no longer provide base flood protection. (a) General. (1) This section describes the procedures to follow and the types of information...

44 CFR 65.14 - Remapping of areas for which local flood protection systems no longer provide base flood protection.

Code of Federal Regulations, 2013 CFR

2013-10-01

... local flood protection systems no longer provide base flood protection. 65.14 Section 65.14 Emergency... § 65.14 Remapping of areas for which local flood protection systems no longer provide base flood protection. (a) General. (1) This section describes the procedures to follow and the types of information...

44 CFR 65.14 - Remapping of areas for which local flood protection systems no longer provide base flood protection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... local flood protection systems no longer provide base flood protection. 65.14 Section 65.14 Emergency... § 65.14 Remapping of areas for which local flood protection systems no longer provide base flood protection. (a) General. (1) This section describes the procedures to follow and the types of information...

Ap4A induces apoptosis in human cultured cells.

PubMed

Vartanian, A; Alexandrov, I; Prudowski, I; McLennan, A; Kisselev, L

1999-07-30

Diadenosine oligophosphates (Ap(n)A) have been proposed as intracellular and extracellular signaling molecules in animal cells. The ratio of diadenosine 5',5'''-P1,P3-triphosphate to diadenosine 5',5'''-P1,P4-tetraphosphate (Ap3A/Ap4A) is sensitive to the cellular status and alters when cultured cells undergo differentiation or are treated with interferons. In cells undergoing apoptosis induced by DNA topoisomerase II inhibitor VP16, the concentration of Ap3A decreases significantly while that of Ap4A increases. Here, we have examined the effects of exogenously added Ap3A and Ap4A on apoptosis and morphological differentiation. Penetration of Ap(n)A into cells was achieved by cold shock. Ap4A at 10 microM induced programmed cell death in human HL60, U937 and Jurkat cells and mouse VMRO cells and this effect appeared to require Ap4A breakdown as hydrolysis-resistant analogues of Ap4A were inactive. On its own, Ap3A induced neither apoptosis nor cell differentiation but did display strong synergism with the protein kinase C activators 12-deoxyphorbol-13-O-phenylacetate and 12-deoxyphorbol-13-O-phenylacetate-20-acetate in inducing differentiation of HL60 cells. We propose that Ap4A and Ap3A are physiological antagonists in determination of the cellular status: Ap4A induces apoptosis whereas Ap3A is a co-inductor of differentiation. In both cases, the mechanism of signal transduction remains unknown.

Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia.

PubMed

Boord, Jeffrey B; Maeda, Kazuhisa; Makowski, Liza; Babaev, Vladimir R; Fazio, Sergio; Linton, MacRae F; Hotamisligil, Gökhan S

2002-10-01

The adipocyte fatty acid-binding protein, aP2, has important effects on insulin resistance, lipid metabolism, and atherosclerosis. Its expression in macrophages enhances early foam cell formation and atherosclerosis in vivo. This study was designed to determine whether aP2 deficiency has a similar effect in the setting of advanced atherosclerosis and severe hypercholesterolemia. Mice deficient in aP2 and apolipoprotein E (aP2(-/-)apoE(-/-) mice) and apolipoprotein E-deficient control mice (apoE(-/-) mice) were fed a Western diet for 14 weeks. No significant differences in fasting serum levels of cholesterol, triglycerides, or free fatty acids were found between groups for each sex. Compared with apoE(-/-) control mice, male and female aP2(-/-)apoE(-/-) mice had significant reductions in mean atherosclerotic lesion size in the proximal aorta, en face aorta, and innominate/right carotid artery. Feeding the Western diet in the apoE-deficient background did not cause a significant reduction in insulin sensitivity in vivo, as determined by steady-state serum glucose levels and insulin tolerance testing. These data demonstrate an important role for aP2 expression in the advanced stages of atherosclerotic lesion formation. Thus, aP2 provides an important physiological link between different features of the metabolic syndrome and is a potential target for therapy of atherosclerosis.

Flood susceptibility analysis through remote sensing, GIS and frequency ratio model

NASA Astrophysics Data System (ADS)

Samanta, Sailesh; Pal, Dilip Kumar; Palsamanta, Babita

2018-05-01

Papua New Guinea (PNG) is saddled with frequent natural disasters like earthquake, volcanic eruption, landslide, drought, flood etc. Flood, as a hydrological disaster to humankind's niche brings about a powerful and often sudden, pernicious change in the surface distribution of water on land, while the benevolence of flood manifests in restoring the health of the thalweg from excessive siltation by redistributing the fertile sediments on the riverine floodplains. In respect to social, economic and environmental perspective, flood is one of the most devastating disasters in PNG. This research was conducted to investigate the usefulness of remote sensing, geographic information system and the frequency ratio (FR) for flood susceptibility mapping. FR model was used to handle different independent variables via weighted-based bivariate probability values to generate a plausible flood susceptibility map. This study was conducted in the Markham riverine precinct under Morobe province in PNG. A historical flood inventory database of PNG resource information system (PNGRIS) was used to generate 143 flood locations based on "create fishnet" analysis. 100 (70%) flood sample locations were selected randomly for model building. Ten independent variables, namely land use/land cover, elevation, slope, topographic wetness index, surface runoff, landform, lithology, distance from the main river, soil texture and soil drainage were used into the FR model for flood vulnerability analysis. Finally, the database was developed for areas vulnerable to flood. The result demonstrated a span of FR values ranging from 2.66 (least flood prone) to 19.02 (most flood prone) for the study area. The developed database was reclassified into five (5) flood vulnerability zones segmenting on the FR values, namely very low (less that 5.0), low (5.0-7.5), moderate (7.5-10.0), high (10.0-12.5) and very high susceptibility (more than 12.5). The result indicated that about 19.4% land area as `very high

Proposal of global flood vulnerability scenarios for evaluating future potential flood losses

NASA Astrophysics Data System (ADS)

Kinoshita, Y.; Tanoue, M.; Watanabe, S.; Hirabayashi, Y.

2015-12-01

Flooding is one of the most hazardous and damaging natural disasters causing serious economic loss and casualties across the world (Jongman et al., 2015). Previous studies showed that the global temperature increase affects regional weather pattern, and several general circulation model (GCM) simulations suggest the increase of flood events in both frequency and magnitude in many parts of the world (Hirabayashi et al., 2013). Effective adaptation to potential flood risks under the warming climate requires an in-depth understanding of both the physical and socioeconomic contributors of the flood risk. To assess the realistic future potential flood risk, future sophisticated vulnerability scenarios associated with the shared socioeconomic pathways (SSPs) are necessary. In this study we propose a new future vulnerability scenarios in mortality. Our vulnerability scenarios are constructed based on the modeled flood exposure (population potentially suffered by flooding) and a past from 1980 to 2005. All the flood fatality data were classified according to four income levels (high, mid-high, mid-low and low). Our proposed scenarios have three pathways regarding to SSPs; High efficiency (HE) scenario (SSP1, SSP4 (rich country) and SSP5), Medium efficiency (ME) scenario (SSP2), and Low efficiency (LE) scenario (SSP3 and SSP4 (poor country)). The maximum mortality protection level on each category was detected by applying exponential curve fitting with offset term. Slopes in the HE scenario are assumed to be equal to slopes estimated by regression analysis in each category. The slope in the HE scenario is defined by the mean value of all countries' slope value that is approximately -0.33 mortality decreases per year. The EM-DAT mortality data shows a decreasing trend in time in almost all of the countries. Although mortalities in some countries show an increasing trend, this is because these countries were affected by once-in-hundred-years floods after 1990's. The slope in

Adipocyte Fatty Acid–Binding Protein, aP2, Alters Late Atherosclerotic Lesion Formation in Severe Hypercholesterolemia

PubMed Central

Boord, Jeffrey B.; Maeda, Kazuhisa; Makowski, Liza; Babaev, Vladimir R.; Fazio, Sergio; Linton, MacRae F.; Hotamisligil, Gökhan S.

2014-01-01

Objective The adipocyte fatty acid-binding protein, aP2, has important effects on insulin resistance, lipid metabolism, and atherosclerosis. Its expression in macrophages enhances early foam cell formation and atherosclerosis in vivo. This study was designed to determine whether aP2 deficiency has a similar effect in the setting of advanced atherosclerosis and severe hypercholesterolemia. Methods and Results Mice deficient in aP2 and apolipoprotein E (aP2−/−apoE−/− mice) and apolipoprotein E-deficient control mice (apoE−/− mice) were fed a Western diet for 14 weeks. No significant differences in fasting serum levels of cholesterol, triglycerides, or free fatty acids were found between groups for each sex. Compared with apoE−/− control mice, male and female aP2−/−apoE−/− mice had significant reductions in mean atherosclerotic lesion size in the proximal aorta, en face aorta, and innominate/right carotid artery. Feeding the Western diet in the apoE-deficient background did not cause a significant reduction in insulin sensitivity in vivo, as determined by steady-state serum glucose levels and insulin tolerance testing. Conclusions These data demonstrate an important role for aP2 expression in the advanced stages of atherosclerotic lesion formation. Thus, aP2 provides an important physiological link between different features of the metabolic syndrome and is a potential target for therapy of atherosclerosis. PMID:12377750

75 FR 62137 - Notice of Public Meeting; Proposed Alluvial Valley Floor Coal Exchange Public Interest Factors...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

...; MTM-99236] Notice of Public Meeting; Proposed Alluvial Valley Floor Coal Exchange Public Interest... (SMCRA) of 1977. This exchange (serial number MTM-99236) has been proposed by Jay Nance, Brett A... Director. [FR Doc. 2010-25060 Filed 10-6-10; 8:45 am] BILLING CODE 4310-DN-P ...

Diagnostic utility of aP2/FABP4 expression in soft tissue tumours.

PubMed

Kashima, T G; Turley, H; Dongre, A; Pezzella, F; Athanasou, N A

2013-04-01

Adipocyte P2 (aP2), also known as fatty acid-binding protein 4 (FABP4), is a fatty acid-binding protein found in the cytoplasm of cells of adipocyte differentiation. In this study, we examined a large number of soft tissue tumours with a commercial polyclonal anti-aP2/FABP4 antibody and a newly developed mouse monoclonal antibody raised against this protein to determine the diagnostic utility of aP2/FABP4 as a marker of tumours of adipose differentiation. A mouse monoclonal antibody, clone 175d, was raised against a mixture of synthetic peptides corresponding to the amino acid sequence of residues 10-28 and 121-132 of the human aP2/FABP4 protein. Antigen expression with polyclonal and monoclonal antibodies was immunohistochemically determined in paraffin sections of normal adipose tissue and a wide range of benign and malignant primary soft tissue tumours (n = 200). aP2/FABP4 was expressed around the cytoplasmic lipid vacuole in white and brown fat cells in benign lipomas and hibernomas. Immature fat cells and lipoblasts in spindle cell/pleomorphic lipoma, atypical lipomatous tumour/well-differentiated liposarcoma, myxoid/round cell liposarcoma and pleomorphic liposarcoma also reacted strongly for aP2/FABP4. No specific staining was seen in non-adipose benign and malignant mesenchymal and non-mesenchymal tumours. aP2/FABP4 is expressed by mature and immature fat cells and is a marker of tumours of adipose differentiation. Immunophenotypic aP2/FABP4 expression is useful in identifying lipoblasts, and immunohistochemistry with polyclonal/monoclonal anti-aP2/FABP4 antibodies should be useful in distinguishing liposarcoma from other malignancies, particularly round cell, myxoid and pleomorphic soft tissue sarcomas.

Is the Shine off the A.P. Apple?

ERIC Educational Resources Information Center

Hurwitz, Nina; Hurwitz, Sol

2003-01-01

Describes challenges facing College Board's efforts to expand Advanced Placement (A.P.) courses to provide equal access to previously underserved low-performing urban and rural school students while maintaining the program's high academic standards. Includes list of strategies school boards can use to achieve greater access to A.P. courses while…

78 FR 41005 - Airworthiness Directives; Vulcanair S.p.A. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... Internet at http://www.regulations.gov ; or in person at the Docket Management Facility between 9 a.m. and... after receipt. FOR FURTHER INFORMATION CONTACT: Mike Kiesov, Aerospace Safety Engineer, FAA, Small...,'' AP68TP 600 ``VIATOR,'' and P68 ``OBSERVER 2'' airplanes. Since we issued AD 2008-24-11 (73 FR 72314...

78 FR 45943 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

... Health Department, Road and Bridge Building, 3800 Five Notch Road, Marshall, TX 75670. Unincorporated... Five Notch Road, Marshall, TX 75670. (Catalog of Federal Domestic Assistance No. 97.022, ``Flood...

76 FR 3595 - Proposed Flood Elevation Determinations for Cumberland County, ME (All Jurisdictions)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2008-0020; Internal Agency Docket No. FEMA-B-1060] Proposed Flood Elevation Determinations for Cumberland County, ME (All Jurisdictions) AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of...

75 FR 59192 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... of Perry, downstream of the Township of Toby. confluence with Black Fox Run. Approximately 480 feet... No. 97.022, ``Flood Insurance.'') Dated: September 13, 2010. Sandra K. Knight, Deputy Federal...

14 CFR 1260.10 - Proposals.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Pre-Award Requirements § 1260.10 Proposals. (a) Consistent with 31 U.S.C. 6301(3), NASA's policy is to... submitted in response to a Broad Agency Announcement (BAA) such as a NASA Research Announcement (NRA) or an... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's...

14 CFR 1260.10 - Proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Pre-Award Requirements § 1260.10 Proposals. (a) Consistent with 31 U.S.C. 6301(3), NASA's policy is to... submitted in response to a Broad Agency Announcement (BAA) such as a NASA Research Announcement (NRA) or an... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's...

14 CFR 1260.10 - Proposals.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Pre-Award Requirements § 1260.10 Proposals. (a) Consistent with 31 U.S.C. 6301(3), NASA's policy is to... submitted in response to a Broad Agency Announcement (BAA) such as a NASA Research Announcement (NRA) or an... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's...

14 CFR 1260.10 - Proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Pre-Award Requirements § 1260.10 Proposals. (a) Consistent with 31 U.S.C. 6301(3), NASA's policy is to... submitted in response to a Broad Agency Announcement (BAA) such as a NASA Research Announcement (NRA) or an... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's...

75 FR 78650 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

..., Mississippi, and Incorporated Areas Big Black River Approximately 21.9 None +149 Unincorporated Areas of miles.... 97.022, ``Flood Insurance.'') Dated: December 3, 2010. Sandra K. Knight, Deputy Federal Insurance and...

77 FR 18846 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

... panels of experts in hydrology, hydraulics, and other pertinent sciences established to review... Incorporated Areas Maps Available for Inspection Online at: http://www.dnr.sc.gov/water/flood/comaps.html City...

77 FR 18841 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other pertinent....gov/water/flood/comaps.html City of Greenville City Hall, 206 South Main Street, Greenville, SC 29602...

77 FR 58562 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-21

.... Village of Black River Village Office, 107 Jefferson Place, Black River, NY 13612. Weber County, Utah, and... Assistance No. 97.022, ``Flood Insurance.'') Dated: September 3, 2012. Sandra K. Knight, Deputy Associate...

77 FR 44651 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other pertinent... Online at: http://www.dnr.sc.gov/water/flood/comaps.html Town of Springfield Town Hall, 1505 Georgia...

77 FR 55856 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other pertinent... Inspection Online at: http://www.dnr.sc.gov/water/flood/comaps.html City of Florence Planning, Research and...

Dissociation between the effects of P1, P4-diadenosine tetraphosphate (Ap4A) on renal haemodynamics and tubular function in anaesthetized rats.

PubMed

Jankowski, M; Angielski, S; Szczepańska-Konkel, M

2008-03-01

Previous studies from our laboratory have reported a marked reduction in glomerular filtration rate (GFR) and sodium reabsorption in renal proximal tubule during intravenous infusion of P(1),P(4)-diadenosine tetraphosphate (Ap(4)A) at dose of 1.0 micromol/kg + 10 nmol/kg/min (i.v., injection followed by infusion) in anaesthetized Wistar rats. In the present study, the changes of GFR and urine sodium excretion were investigated in response to systemic infusion of Ap(4)A at different doses. Ap(4)A at dose of 0.1 micromol/kg + 1.0 nmol/kg/min did not change GFR and sodium urinary excretion whereas 2-fold higher dose produced significant (3.4-fold) increase in sodium excretion without changes in GFR. Significant but transient reduction in GFR by approximately 21% was observed during infusion of Ap(4)A at dose of 0.5 micromol/kg + 5.0 nmol/kg/min. Higher doses of Ap(4)A (1.0 micromol/kg + 10 nmol/kg/min and 2.0 micromol/kg + 20 nmol/kg/min) reduction in GFR and marked natriuresis. Our results suggest that tubular sodium transport systems are more sensitive to Ap(4)A than systems involved in GFR regulation.

75 FR 3885 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-25

... meters (MSL) Effective Modified Napa County, California, and Incorporated Areas Napa Creek At the... flooding area, +17 2 approximately 1,400 feet northeast of intersection of Imola Avenue and Gasser Drive... meter. [[Page 3886

Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula.

PubMed

Zhou, Bin; Wu, Yan; Dalal, Seema; Cassera, Maria B; Yue, Jian-Min

2016-08-26

Aqueous ethanol extracts of powdered twigs of Euphorbia esula afforded 16 new diterpenoids, named euphorbesulins A-P. These euphorbesulins included presegetane (1-3), jatrophane (4-14), paraliane (15), and isopimarane (16) diterpenoids as well as six known analogues. Compounds 1-3 represent a rare type of presegetane diterpenoid. Their structures were determined by analysis of the spectroscopic data, and the absolute configuration of 1 was established by X-ray crystallography. Diterpenoid 7 showed low nanomolar antimalarial activity, while the remaining compounds showed only moderate or no antimalarial activity.

WCPSS Advanced Placement (AP) Test Results, 2009-10. E&R Report No. 10.29

ERIC Educational Resources Information Center

McMillen, Brad

2010-01-01

Analysis of WCPSS' 2009-10 AP reports from the College Board reveal that the number and proportion of WCPSS students taking AP courses and exams continues to grow. Between 1996-97 and 2009-10, the number of students enrolled in WCPSS grew by approximately 63% and the number taking AP exams increased by 238% with a corresponding increase in exams…

48 CFR 215.404-1 - Proposal analysis techniques.

Code of Federal Regulations, 2010 CFR

2010-10-01

... reliability of its estimating and accounting systems. [63 FR 55040, Oct. 14, 1998, as amended at 71 FR 69494... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Proposal analysis techniques. 215.404-1 Section 215.404-1 Federal Acquisition Regulations System DEFENSE ACQUISITION...

76 FR 58436 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-21

.... Approximately 105 feet None [caret]500 upstream of Haihai Street. Shallow Flooding Approximately 2.8 miles None 2 Hawaii County. northeast of the intersection of Ka'Ulu Street and 'Ahinahina Place. Shallow... and Naupaka Kai Place. [[Page 58438

77 FR 76998 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... provides corrections to that table, to be used in lieu of the information published at 75 FR 29219. The..., Hickory Camp Creek (backwater effects from Green River), Hickory Camp Creek Tributary 1 (backwater effects... 39.1 (backwater effects from Green River), Panther Creek (backwater effects from Green River), Pipe...

76 FR 54415 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

... following flooding sources: Bear Creek (backwater effects from Cumberland River), Big Renox Creek (backwater effects from Cumberland River), Big Whetstone Creek (backwater effects from Cumberland River), Big Willis... River), Big Renox Creek (backwater effects from Cumberland River), Big Whetstone Creek (backwater...

75 FR 59741 - Notice of Proposed Withdrawal and Opportunity for Public Meeting; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMTB072000-L14300000-ET0000; MTM 98499] Notice of Proposed Withdrawal and Opportunity for Public Meeting; Montana AGENCY: Bureau of Land.... [FR Doc. 2010-24281 Filed 9-27-10; 8:45 am] BILLING CODE 4310-$$-P ...

77 FR 66788 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

...). Specifically, it addresses the following flooding sources: Demarest Kill, East Branch Hackensack River, Golf... Hackensack River, Golf Course Brook, Hackensack River, Minisceongo Creek, Nauraushaun Brook, North Branch... Town of Clarkstown. Old Mill Road. Approximately 600 feet +150 +151 downstream of Rockland Lake. Golf...

77 FR 73394 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... and modified elevations, and communities affected for Mercer County, Pennsylvania (All Jurisdictions... determinations of Base (1% annual-chance) Flood Elevations (BFEs) and modified BFEs for communities participating... not be construed to mean that the community must change any existing ordinances that are more...

78 FR 22222 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... of referenced elevations, effective and modified elevations, and communities affected for Mercer...) and modified BFEs for communities participating in the National Flood Insurance Program (NFIP), in... CFR 60.3, are minimum requirements. They should not be construed to mean that the community must...

77 FR 51743 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... modified elevations, and communities affected for the City of Newport News, Virginia. Specifically, it.... The table, entitled ``City of Newport News, Virgina'' addressed the flooding sources Newmarket Creek... Modified City of Newport News, Virginia Virginia City of Newport News.... Newmarket Creek Approximately 0...

Ministry of Defence Main Estimates 2009-10

DTIC Science & Technology

2009-07-02

fR 2 M O G C ha ng es " 13 .7 " 13 .7 " 13 .7 0. 0 F le x C ap it al to R es ou rc e. 60 0. 0 60 0. 0...as h R el ea se 48 .9 48 .9 " 48 .9 0 0. 0 N D P B C os ts 13 2. 1 9. 5 14 1. 6 14 1. 6 0. 9 0. 9 R fR 1 T ot al 23 ,8 87 .1 11 ,6 32 .5 35 ,5 19 .6 17...rs O ut " 28 .0 " 28 .0 " 28 .0 R es er ve B id 2, 38 4. 3 42 2.

77 FR 70454 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... which included a Web page address through which the Preliminary Flood Insurance Rate Map (FIRM), and... be accessed. The information available through the Web page address has subsequently been updated... through the web page address listed in the table has been updated to reflect the Revised Preliminary...

76 FR 72661 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

... Environmental Policy Act. This proposed rule is categorically excluded from the requirements of 44 CFR part 10... County, Connecticut (All Jurisdictions) Long Island Sound Approximately 1,000 +9 +10 Borough of Fenwick... Jurisdictions) Choconut Creek Approximately 0.9 mile +1039 +1038 Township of Choconut. downstream of Kellum Road...

76 FR 56724 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

.../town/county Source of flooding Location ** ground [caret] Elevation in meters (MSL) Existing Modified... Datum. Depth in feet above ground. [caret] Mean Sea Level, rounded to the nearest 0.1 meter. ** BFEs to... upstream of Cradduck Road None +876 Oklahoma Unincorporated Areas of Town Branch Approximately 400 feet...

78 FR 20339 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-04

... may submit comments, identified by Docket No. FEMA-B-1301, to Luis Rodriguez, Chief, Engineering... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... accordance with section 110 of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a...

76 FR 13572 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

.... Specifically, it addresses the following flooding sources: Left Bank Overflow Main Stem Skagit River, Left Bank Overflow Main Stem Skagit River/South Fork Skagit River, Left Bank Overflow North Fork Skagit River, Main Stem Skagit River, North Fork Skagit River, Overflow from the Main Stem Skagit River between the North...

77 FR 46994 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... referenced locations above. Please refer to the revised Flood Insurance Rate Map located at the community map repository (see below) for exact locations of all BFEs to be changed. Send comments to Luis Rodriguez, Chief... Agency, 500 C Street SW., Washington, DC 20472. ADDRESSES City of Cleveland Maps are available for...

77 FR 67325 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

... the revised Flood Insurance Rate Map located at the community map repository (see below) for exact...., Washington, DC 20472. ADDRESSES City of Baraboo Maps are available for inspection at City Hall, 135 4th Street, Baraboo, WI 53913. City of Reedsburg Maps are available for inspection at City Hall, 134 South...

76 FR 43966 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... confluence. Approximately 650 feet None +657 downstream of Farm Road. School Creek At the Farm Creek None.... Specifically, it addresses the flooding sources Bull Run Creek, Dempsey Creek, Farm Creek, Fond Du Lac Creek, Illinois River, Lick Creek, Mackinaw River, Prairie Creek, and School Creek. DATES: Comments are to be...

77 FR 29678 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other pertinent..., and Incorporated Areas Maps Available for Inspection Online at: http://www.in.gov/dnr/water/7293.htm... Online at: http://www.dnr.sc.gov/water/flood/comaps.html City of Manning 29 West Boyce Street, Manning...

77 FR 66791 - Proposed Flood Elevation Determinations for Wicomico County, MD, and Incorporated Areas

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA-2010-0003; Internal Agency Docket No. FEMA-B-1085] Proposed Flood Elevation Determinations for Wicomico..., identified by Docket No. FEMA-B- 1085, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...

77 FR 50668 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... County, Texas, and Incorporated Areas. Specifically, it addresses the flooding sources: Black Fork Creek, Black Fork Creek Tributary BF-1, Black Fork Creek Tributary BF-M-1, Black Fork Creek Tributary D, Black Fork Creek Tributary D-1, Black Fork Creek Tributary D-2, Black Fork Creek Tributary D-3, Butler Creek...

75 FR 61373 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... located at the community map repository (see below) for exact locations of all BFEs to be changed. Send... located at the community map repository (see below) for exact locations of all BFEs to be changed. Send.... Please refer to the revised Flood Insurance Rate Map located at the community map repository (see below...

77 FR 17462 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

... DEPARTMENT OF DEFENSE Department of the Army [Docket ID USA-2012-0006] Proposed Collection..., Department of Defense. [FR Doc. 2012-7074 Filed 3-23-12; 8:45 am] BILLING CODE 5001-06-P ... of 1995, the Department of the Army announces a proposed public information collection and seeks...

Flood triggering in Switzerland: the role of daily to monthly preceding precipitation

NASA Astrophysics Data System (ADS)

Froidevaux, P.; Schwanbeck, J.; Weingartner, R.; Chevalier, C.; Martius, O.

2015-09-01

Determining the role of different precipitation periods for peak discharge generation is crucial for both projecting future changes in flood probability and for short- and medium-range flood forecasting. In this study, catchment-averaged daily precipitation time series are analyzed prior to annual peak discharge events (floods) in Switzerland. The high number of floods considered - more than 4000 events from 101 catchments have been analyzed - allows to derive significant information about the role of antecedent precipitation for peak discharge generation. Based on the analysis of precipitation times series, a new separation of flood-related precipitation periods is proposed: (i) the period 0 to 1 day before flood days, when the maximum flood-triggering precipitation rates are generally observed, (ii) the period 2 to 3 days before flood days, when longer-lasting synoptic situations generate "significantly higher than normal" precipitation amounts, and (iii) the period from 4 days to 1 month before flood days when previous wet episodes may have already preconditioned the catchment. The novelty of this study lies in the separation of antecedent precipitation into the precursor antecedent precipitation (4 days before floods or earlier, called PRE-AP) and the short range precipitation (0 to 3 days before floods, a period when precipitation is often driven by one persistent weather situation like e.g., a stationary low-pressure system). A precise separation of "antecedent" and "peak-triggering" precipitation is not attempted. Instead, the strict definition of antecedent precipitation periods permits a direct comparison of all catchments. The precipitation accumulating 0 to 3 days before an event is the most relevant for floods in Switzerland. PRE-AP precipitation has only a weak and region-specific influence on flood probability. Floods were significantly more frequent after wet PRE-AP periods only in the Jura Mountains, in the western and eastern Swiss plateau, and at

Flood triggering in Switzerland: the role of daily to monthly preceding precipitation

NASA Astrophysics Data System (ADS)

Froidevaux, P.; Schwanbeck, J.; Weingartner, R.; Chevalier, C.; Martius, O.

2015-03-01

Determining the role of different precipitation periods for peak discharge generation is crucial for both projecting future changes in flood probability and for short- and medium-range flood forecasting. We analyze catchment-averaged daily precipitation time series prior to annual peak discharge events (floods) in Switzerland. The high amount of floods considered - more than 4000 events from 101 catchments have been analyzed - allows to derive significant information about the role of antecedent precipitation for peak discharge generation. Based on the analysis of precipitation times series, we propose a new separation of flood-related precipitation periods: (i) the period 0 to 1 day before flood days, when the maximum flood-triggering precipitation rates are generally observed, (ii) the period 2 to 3 days before flood days, when longer-lasting synoptic situations generate "significantly higher than normal" precipitation amounts, and (iii) the period from 4 days to one month before flood days when previous wet episodes may have already preconditioned the catchment. The novelty of this study lies in the separation of antecedent precipitation into the precursor antecedent precipitation (4 days before floods or earlier, called PRE-AP) and the short range precipitation (0 to 3 days before floods, a period when precipitation is often driven by one persistent weather situation like e.g. a stationary low-pressure system). Because we consider a high number of events and because we work with daily precipitation values, we do not separate the "antecedent" and "peak-triggering" precipitation. The whole precipitation recorded during the flood day is included in the short-range antecedent precipitation. The precipitation accumulating 0 to 3 days before an event is the most relevant for floods in Switzerland. PRE-AP precipitation has only a weak and region-specific influence on flood probability. Floods were significantly more frequent after wet PRE-AP periods only in the Jura

76 FR 61649 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... Insurance Rate Map located at the community map repository (see below) for exact locations of all BFEs to be... Insurance Rate Map located at the community map repository (see below) for exact locations of all BFEs to be... revised Flood Insurance Rate Map located at the community map repository (see below) for exact locations...

75 FR 19320 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... Incorporated Areas Basin 10, Stream 14 At the Franklin/Wake +306 +307 Unincorporated Areas of county boundary... Approximately 250 feet None +344 Unincorporated Areas of upstream of Keighlely Franklin County. Forest Drive.../Wake None +327 Unincorporated Areas of county boundary. Franklin County. Approximately 0.6 mile None...

Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindner, Scott E.; De Silva, Erandi K.; Keck, James L.

2010-11-05

Putative transcription factors have only recently been identified in the Plasmodium spp., with the major family of regulators comprising the Apicomplexan Apetala2 (AP2) proteins. To better understand the DNA-binding mechanisms of these transcriptional regulators, we characterized the structure and in vitro function of an AP2 DNA-binding domain from a prototypical Apicomplexan AP2 protein, PF14{_}0633 from Plasmodium falciparum. The X-ray crystal structure of the PF14{_}0633 AP2 domain bound to DNA reveals a {beta}-sheet fold that binds the DNA major groove through base-specific and backbone contacts; a prominent {alpha}-helix supports the {beta}-sheet structure. Substitution of predicted DNA-binding residues with alanine weakened ormore » eliminated DNA binding in solution. In contrast to plant AP2 domains, the PF14{_}0633 AP2 domain dimerizes upon binding to DNA through a domain-swapping mechanism in which the {alpha}-helices of the AP2 domains pack against the {beta}-sheets of the dimer mates. DNA-induced dimerization of PF14{_}0633 may be important for tethering two distal DNA loci together in the nucleus and/or for inducing functional rearrangements of its domains to facilitate transcriptional regulation. Consistent with a multisite binding mode, at least two copies of the consensus sequence recognized by PF14{_}0633 are present upstream of a previously identified group of sporozoite-stage genes. Taken together, these findings illustrate how Plasmodium has adapted the AP2 DNA-binding domain for genome-wide transcriptional regulation.« less

78 FR 10195 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes...- March 6, 2013 090072 Falls (12-01- Gerald F. Hall, 10 Maple team.com/starr/ 1573P). Smith, First Avenue...://www.starr- March 27, 2013 160090 (11-10-1574P). Nancy Chaney, Development, 221 team.com/starr/LOMR...

76 FR 2892 - Proposed Subsequent Arrangement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-18

... Peaceful Uses of Nuclear Energy and the Agreement for Cooperation in the Peaceful Uses of Nuclear Energy... Energy. Thomas P. D'Agostino, Administrator, National Nuclear Security Administration. [FR Doc. 2011-905... DEPARTMENT OF ENERGY Proposed Subsequent Arrangement AGENCY: Office of Nonproliferation and...

75 FR 9568 - Standard Time Zone Boundary in the State of North Dakota: Proposed Change for Mercer County...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-03

... hearing on this issue from 7-10 p.m. (Mountain Daylight Time) on Friday, May 14, 2010, in the ``Large Room... referendum favored changing to central time by a vote of 1,180 to 1038. However, a majority of written... middle of the Missouri River. * * * * * [FR Doc. 2010-4372 Filed 3-2-10; 8:45 am] BILLING CODE 4910-9X-P ...

14 CFR § 1260.10 - Proposals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Pre-Award Requirements § 1260.10 Proposals. (a) Consistent with 31 U.S.C. 6301(3), NASA's policy is to... submitted in response to a Broad Agency Announcement (BAA) such as a NASA Research Announcement (NRA) or an... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's...

Congenital hyperinsulinism and Poland syndrome in association with 10p13-14 duplication.

PubMed

Giri, Dinesh; Patil, Prashant; Hart, Rachel; Didi, Mohammed; Senniappan, Senthil

2017-01-01

Poland syndrome (PS) is a rare congenital condition, affecting 1 in 30 000 live births worldwide, characterised by a unilateral absence of the sternal head of the pectoralis major and ipsilateral symbrachydactyly occasionally associated with abnormalities of musculoskeletal structures. A baby girl, born at 40 weeks' gestation with birth weight of 3.33 kg (-0.55 SDS) had typical phenotypical features of PS. She had recurrent hypoglycaemic episodes early in life requiring high concentration of glucose and glucagon infusion. The diagnosis of congenital hyperinsulinism (CHI) was biochemically confirmed by inappropriately high plasma concentrations of insulin and C-peptide and low plasma free fatty acids and β-hydroxyl butyrate concentrations during hypoglycaemia. Sequencing of ABCC8 , KCNJ11 and HNF4A did not show any pathogenic mutation. Microarray analysis revealed a novel duplication in the short arm of chromosome 10 at 10p13-14 region. This is the first reported case of CHI in association with PS and 10p duplication. We hypothesise that the HK1 located on the chromosome 10 encoding hexokinase-1 is possibly linked to the pathophysiology of CHI. Congenital hyperinsulinism (CHI) is known to be associated with various syndromes.This is the first reported association of CHI and Poland syndrome (PS) with duplication in 10p13-14.A potential underlying genetic link between 10p13-14 duplication, PS and CHI is a possibility.

45 CFR 1641.14 - Notice of proposed suspension.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Notice of proposed suspension. 1641.14 Section 1641.14 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION DEBARMENT, SUSPENSION AND REMOVAL OF RECIPIENT AUDITORS Suspension § 1641.14 Notice of proposed suspension...

45 CFR 1641.14 - Notice of proposed suspension.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Notice of proposed suspension. 1641.14 Section 1641.14 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION DEBARMENT, SUSPENSION AND REMOVAL OF RECIPIENT AUDITORS Suspension § 1641.14 Notice of proposed suspension...

Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.

PubMed

Marriott, Andrew S; Copeland, Nikki A; Cunningham, Ryan; Wilkinson, Mark C; McLennan, Alexander G; Jones, Nigel J

2015-09-01

The level of intracellular diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) increases several fold in mammalian cells treated with non-cytotoxic doses of interstrand DNA-crosslinking agents such as mitomycin C. It is also increased in cells lacking DNA repair proteins including XRCC1, PARP1, APTX and FANCG, while >50-fold increases (up to around 25 μM) are achieved in repair mutants exposed to mitomycin C. Part of this induced Ap4A is converted into novel derivatives, identified as mono- and di-ADP-ribosylated Ap4A. Gene knockout experiments suggest that DNA ligase III is primarily responsible for the synthesis of damage-induced Ap4A and that PARP1 and PARP2 can both catalyze its ADP-ribosylation. Degradative proteins such as aprataxin may also contribute to the increase. Using a cell-free replication system, Ap4A was found to cause a marked inhibition of the initiation of DNA replicons, while elongation was unaffected. Maximum inhibition of 70-80% was achieved with 20 μM Ap4A. Ap3A, Ap5A, Gp4G and ADP-ribosylated Ap4A were without effect. It is proposed that Ap4A acts as an important inducible ligand in the DNA damage response to prevent the replication of damaged DNA. Copyright © 2015 Elsevier B.V. All rights reserved.

77 FR 55785 - Proposed Flood Elevation Determinations; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... stream reach between the referenced locations above. Please refer to the revised Flood Insurance Rate Map located at the community map repository (see below) for exact locations of all BFEs to be changed. Send... Mechanicsville Maps are available for inspection at the Borough Hall, 1342 Pottsville Street, Mechanicsville, PA...

P1,P4-diadenosine tetraphosphate (Ap4A) inhibits proximal tubular reabsorption of sodium in rats.

PubMed

Stiepanow-Trzeciak, Anna; Jankowski, Maciej; Angielski, Stefan; Szczepanska-Konkel, Miroslawa

2007-01-01

P1,P4-diadenosine tetraphosphate (Ap4A) is a vasoactive dinucleotide possessing natriuretic activity. It is unclear, however, which part of the nephron is the target site of action for Ap4A. We evaluated the tubular sites of Ap4A action using the lithium clearance technique. Ap4A at a priming dose of 2 micromol/kg with subsequent infusion at 20 nmol/kg/min increased fractional water and sodium excretion 2.5- and 5.6-fold, respectively. Moreover, Ap4A increased lithium clearance 1.9-fold and fractional lithium excretion 2.8-fold. Fractional water and sodium excretion from distal nephron segments was not significantly affected by Ap4A. These results suggest that Ap4A induces natriuresis mainly through inhibition of proximal tubular reabsorption of sodium. Copyright 2007 S. Karger AG, Basel.

The adipocyte fatty acid–binding protein aP2 is required in allergic airway inflammation

PubMed Central

Shum, Bennett O.V.; Mackay, Charles R.; Gorgun, Cem Z.; Frost, Melinda J.; Kumar, Rakesh K.; Hotamisligil, Gökhan S.; Rolph, Michael S.

2006-01-01

The adipocyte fatty acid–binding protein aP2 regulates systemic glucose and lipid metabolism. We report that aP2, in addition to being abundantly expressed by adipocytes, is also expressed by human airway epithelial cells and shows a striking upregulation following stimulation of epithelial cells with the Th2 cytokines IL-4 and IL-13. Regulation of aP2 mRNA expression by Th2 cytokines was highly dependent on STAT6, a transcription factor with a major regulatory role in allergic inflammation. We examined aP2-deficient mice in a model of allergic airway inflammation and found that infiltration of leukocytes, especially eosinophils, into the airways was highly dependent on aP2 function. T cell priming was unaffected by aP2 deficiency, suggesting that aP2 was acting locally within the lung, and analysis of bone marrow chimeras implicated non-hematopoietic cells, most likely bronchial epithelial cells, as the site of action of aP2 in allergic airway inflammation. Thus, aP2 regulates allergic airway inflammation and may provide a link between fatty acid metabolism and asthma. PMID:16841093

Baculovirus p35 gene is oppositely regulated by P53 and AP-1 like factors in Spodoptera frugiperda

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohareer, Krishnaveni; Institute of Life Sciences, University of Hyderabad Campus, Prof. C.R. Rao Road, Gachibowli, Hyderabad 500046; Sahdev, Sudhir

2011-11-04

Highlights: Black-Right-Pointing-Pointer Baculovirus p35 is regulated by both viral and host factors. Black-Right-Pointing-Pointer Baculovirus p35 is negatively regulated by SfP53-like factor. Black-Right-Pointing-Pointer Baculovirus p35 is positively regulated by SfAP-1-like factor. -- Abstract: Baculovirus p35 belongs to the early class of genes of AcMNPV and requires viral factors like Immediate Early protein-1 for its transcription. To investigate the role of host factors in regulating p35 gene expression, the putative transcription factor binding sites were examined in silico and the role of these factors in influencing the transcription of p35 gene was assessed. We focused our studies on AP-1 and P53-like factors,more » which are activated under oxidative stress conditions. The AP-1 motif is located at -1401 while P53 motif is at -1912 relative to p35 translation start site. The predicted AP-1 and P53 elements formed specific complexes with Spodoptera frugiperda nuclear extracts. Both AP-1 and P53 motif binding proteins were down regulated as a function of AcMNPV infection in Spodoptera cells. To address the question whether during an oxidative outburst, the p35 transcription is enhanced; we investigated the role of these oxidative stress induced host transcription factors in influencing p35 gene transcription. Reporter assays revealed that AP-1 element enhances the transcription of p35 by a factor of two. Interestingly, P53 element appears to repress the transcription of p35 gene.« less

Flood Control, Mississippi River, La Crosse, Wisconsin.

DTIC Science & Technology

1975-10-01

end SuP.,tifle) S TYPE OF REPORT & PERIOD COVEkr FINAL ENVIRONMENTAL IMPACT STATEMENT FLOOD CONTROL MISSISSIPPI RIVER LA CROSSE, WISCONSIN Pinal FIq 6...PERFORMING ORG. REPORT NUMBER 7. AUTHOR(e) 0 CONTRACT OR GRANT NUMBER( s ) 9 PERFORMING ORGANIZATION NAME AND ADrRESS 10. PROGRAM ELEMENT. PROJECT, T...rev s eflA ff r,,.e.. ind IdeInify by block rnmber) "-The proposed action is a flood control project consisting of levees, road raises, flood wall

Characterisation of a rare, reassortant human G10P[14] rotavirus strain detected in Honduras

PubMed Central

Quaye, Osbourne; Roy, Sunando; Rungsrisuriyachai, Kunchala; Esona, Mathew D; Xu, Ziqian; Tam, Ka Ian; Banegas, Dina J Castro; Rey-Benito, Gloria; Bowen, Michael D

2018-01-01

BACKGROUND Although first detected in animals, the rare rotavirus strain G10P[14] has been sporadically detected in humans in Slovenia, Thailand, United Kingdom and Australia among other countries. Earlier studies suggest that the strains found in humans resulted from interspecies transmission and reassortment between human and bovine rotavirus strains. OBJECTIVES In this study, a G10P[14] rotavirus genotype detected in a human stool sample in Honduras during the 2010-2011 rotavirus season, from an unvaccinated 30-month old boy who reported at the hospital with severe diarrhea and vomiting, was characterised to determine the possible evolutionary origin of the rare strain. METHODS For the sample detected as G10P[14], 10% suspension was prepared and used for RNA extraction and sequence independent amplification. The amplicons were sequenced by next-generation sequencing using the Illumina MiSeq 150 paired end method. The sequence reads were analysed using CLC Genomics Workbench 6.0 and phylogenetic trees were constructed using PhyML version 3.0. FINDINGS The next generation sequencing and phylogenetic analyses of the 11-segmented genome of the G10P[14] strain allowed classification as G10-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3. Six of the genes (VP1, VP2, VP3, VP6, NSP2 and NSP4) were DS-1-like. NSP1 and NSP5 were AU-1-like and NSP3 was T6, which suggests that multiple reassortment events occurred in the evolution of the strain. The phylogenetic analyses and genetic distance calculations showed that the VP7, VP4, VP6, VP1, VP3, NSP1, NSP3 and NSP4 genes clustered predominantly with bovine strains. NSP2 and VP2 genes were most closely related to simian and human strains, respectively, and NSP5 was most closely related to a rhesus strain. MAIN CONCLUSIONS The genetic characterisation of the G10P[14] strain from Honduras suggests that its genome resulted from multiple reassortment events which were possibly mediated through interspecies transmissions. PMID:29211103

Characterisation of a rare, reassortant human G10P[14] rotavirus strain detected in Honduras.

PubMed

Quaye, Osbourne; Roy, Sunando; Rungsrisuriyachai, Kunchala; Esona, Mathew D; Xu, Ziqian; Tam, Ka Ian; Banegas, Dina J Castro; Rey-Benito, Gloria; Bowen, Michael D

2018-01-01

Although first detected in animals, the rare rotavirus strain G10P[14] has been sporadically detected in humans in Slovenia, Thailand, United Kingdom and Australia among other countries. Earlier studies suggest that the strains found in humans resulted from interspecies transmission and reassortment between human and bovine rotavirus strains. In this study, a G10P[14] rotavirus genotype detected in a human stool sample in Honduras during the 2010-2011 rotavirus season, from an unvaccinated 30-month old boy who reported at the hospital with severe diarrhea and vomiting, was characterised to determine the possible evolutionary origin of the rare strain. For the sample detected as G10P[14], 10% suspension was prepared and used for RNA extraction and sequence independent amplification. The amplicons were sequenced by next-generation sequencing using the Illumina MiSeq 150 paired end method. The sequence reads were analysed using CLC Genomics Workbench 6.0 and phylogenetic trees were constructed using PhyML version 3.0. The next generation sequencing and phylogenetic analyses of the 11-segmented genome of the G10P[14] strain allowed classification as G10-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3. Six of the genes (VP1, VP2, VP3, VP6, NSP2 and NSP4) were DS-1-like. NSP1 and NSP5 were AU-1-like and NSP3 was T6, which suggests that multiple reassortment events occurred in the evolution of the strain. The phylogenetic analyses and genetic distance calculations showed that the VP7, VP4, VP6, VP1, VP3, NSP1, NSP3 and NSP4 genes clustered predominantly with bovine strains. NSP2 and VP2 genes were most closely related to simian and human strains, respectively, and NSP5 was most closely related to a rhesus strain. The genetic characterisation of the G10P[14] strain from Honduras suggests that its genome resulted from multiple reassortment events which were possibly mediated through interspecies transmissions.

Congenital hyperinsulinism and Poland syndrome in association with 10p13–14 duplication

PubMed Central

Giri, Dinesh; Patil, Prashant; Hart, Rachel; Didi, Mohammed

2017-01-01

Summary Poland syndrome (PS) is a rare congenital condition, affecting 1 in 30 000 live births worldwide, characterised by a unilateral absence of the sternal head of the pectoralis major and ipsilateral symbrachydactyly occasionally associated with abnormalities of musculoskeletal structures. A baby girl, born at 40 weeks’ gestation with birth weight of 3.33 kg (−0.55 SDS) had typical phenotypical features of PS. She had recurrent hypoglycaemic episodes early in life requiring high concentration of glucose and glucagon infusion. The diagnosis of congenital hyperinsulinism (CHI) was biochemically confirmed by inappropriately high plasma concentrations of insulin and C-peptide and low plasma free fatty acids and β-hydroxyl butyrate concentrations during hypoglycaemia. Sequencing of ABCC8, KCNJ11 and HNF4A did not show any pathogenic mutation. Microarray analysis revealed a novel duplication in the short arm of chromosome 10 at 10p13–14 region. This is the first reported case of CHI in association with PS and 10p duplication. We hypothesise that the HK1 located on the chromosome 10 encoding hexokinase-1 is possibly linked to the pathophysiology of CHI. Learning points: Congenital hyperinsulinism (CHI) is known to be associated with various syndromes. This is the first reported association of CHI and Poland syndrome (PS) with duplication in 10p13–14. A potential underlying genetic link between 10p13–14 duplication, PS and CHI is a possibility. PMID:28458900

78 FR 54632 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2013-OS-0189] Proposed Collection...) 372-0857. SUPPLEMENTARY INFORMATION: Title; Associated Form; and OMB Number: Department of Defense... Officer, Department of Defense. [FR Doc. 2013-21582 Filed 9-4-13; 8:45 am] BILLING CODE 5001-06-P ...

Molecular Basis for Association of PIPKIγ-p90 with Clathrin Adaptor AP-2*

PubMed Central

Kahlfeldt, Nina; Vahedi-Faridi, Ardeschir; Koo, Seong Joo; Schäfer, Johannes G.; Krainer, Georg; Keller, Sandro; Saenger, Wolfram; Krauss, Michael; Haucke, Volker

2010-01-01

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an essential determinant in clathrin-mediated endocytosis (CME). In mammals three type I phosphatidylinositol-4-phosphate 5-kinase (PIPK) enzymes are expressed, with the Iγ-p90 isoform being highly expressed in the brain where it regulates synaptic vesicle (SV) exo-/endocytosis at nerve terminals. How precisely PI(4,5)P2 metabolism is controlled spatially and temporally is still uncertain, but recent data indicate that direct interactions between type I PIPK and components of the endocytic machinery, in particular the AP-2 adaptor complex, are involved. Here we demonstrated that PIPKIγ-p90 associates with both the μ and β2 subunits of AP-2 via multiple sites. Crystallographic data show that a peptide derived from the splice insert of the human PIPKIγ-p90 tail binds to a cognate recognition site on the sandwich subdomain of the β2 appendage. Partly overlapping aromatic and hydrophobic residues within the same peptide also can engage the C-terminal sorting signal binding domain of AP-2μ, thereby potentially competing with the sorting of conventional YXXØ motif-containing cargo. Biochemical and structure-based mutagenesis analysis revealed that association of the tail domain of PIPKIγ-p90 with AP-2 involves both of these sites. Accordingly the ability of overexpressed PIPKIγ tail to impair endocytosis of SVs in primary neurons largely depends on its association with AP-2β and AP-2μ. Our data also suggest that interactions between AP-2 and the tail domain of PIPKIγ-p90 may serve to regulate complex formation and enzymatic activity. We postulate a model according to which multiple interactions between PIPKIγ-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P2 synthesis during clathrin-mediated SV endocytosis. PMID:19903820

A hydrodynamic modelling of proposed dams in reducing flood hazard in Kelantan Catchment

NASA Astrophysics Data System (ADS)

Maruti, S. F.; Amerudin, S.; Kadir, W. H. W.; Yusof, Z. M.

2018-04-01

Flood is natural disaster that can cause damage and death. The flood that hit Kelantan in 2014 was the worst flood in Malaysian history. Although the disaster could not be avoided, awareness and preparedness could have helped to reduce the impact. Kuala Krai located at the downstream area in Kelantan catchment is the most affected due to the 2014 floods. The confluence of Lebir and Galas rivers into Kelantan river has led to the increase of flood magnitude to the downstream area. Therefore, Kemubu dam and Lebir dam, located along Galas river and Lebir river, respectively, have been proposed by the Kelantan authority to reduce the flood hazard. In this paper, a hydrodynamic modelling study is carried out, which is coupled of 1D and 2D model to simulate the flood event with and without the proposed dams. The model is developed using a Digital Terrain Model (DTM), which was generated from Airborne LiDAR and SRTM data sources. The hydrograph and water level for 2014 floods event were obtained and was set as an input data for boundary conditions. The modelling results of maximum velocity of 33 m/s and water depth of 19 m were used to generate flood hazard map. The result has found that the proposed dams were able to reduce the flood hazard, particularly at Kuala Krai, Kelantan.

78 FR 57622 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-19

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DoD-2013-OS-0194] Proposed Collection; Comment Request AGENCY: Defense Logistics Agency (DLA), DoD. ACTION: Notice. SUMMARY: In compliance with..., Department of Defense. [FR Doc. 2013-22789 Filed 9-18-13; 8:45 am] BILLING CODE 5001-06-P ...

Effects of proposed highway embankment modifications on water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana

USGS Publications Warehouse

Gilbert, J.J.; Schuck-Kolben, R. E.

1987-01-01

Major flooding in the lower Pearl River basin in recent years has caused extensive damage to homes and highways in the area. In 1980 and 1983, Interstate Highway 10 and U.S. Highway 190 were overtopped. In 1983, the Interstate Highway 10 crossing was seriously damaged by the flood. The U.S. Geological Survey, in cooperation with the Louisiana Department of Transportation and Development, Office of Highways, used a two-dimensional finite-element surface-water flow model to evaluate the effects the proposed embankment modifications at Interstate Highway 10 and U.S. Highway 90 on the water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana. The proposed modifications that were considered for the 1983 flood are: (1) Removal of all highway embankments, the natural condition, (2) extension of the West Pearl River bridge by 1,000 feet at U.S. Highway 90, (3) construction of a new 250-foot bridge opening in the U.S. Highways 190 and 90, west of the intersection of the highways. The proposed highway bridge modifications also incorporated lowering of ground-surface elevations under the new bridges to sea level. The modification that provided the largest reduction in backwater, about 35 percent, was a new bridge in Interstate Highway 10. The modification of the West Pearl River bridge at U.S. Highway 90 and replacement of the bridge in U.S. Highway 190 provide about a 25% reduction in backwater each. For the other modification conditions that required structural modifications, maximum backwater computed on the west side of the flood plain ranges from 0.0 to 0.8 foot and on the east side from 0.0 to 0.6 foot. Results show that although backwater is greater on the west side of the flood plain than on the east side, upstream of highway embankments, backwater decreases more rapidly in the upstream direction on the west side of the flood plain than on the east side. Analysis of the proposed modifications indicates that backwater would still occur on

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

PubMed Central

Martinez-Zapien, Denise; Ruiz, Francesc Xavier; Poirson, Juline; Mitschler, André; Ramirez-Ramos, Juan; Forster, Anne; Cousido-Siah, Alexandra; Masson, Murielle; Pol, Scott Vande; Podjarny, Alberto; Travé, Gilles; Zanier, Katia

2015-01-01

Summary The p53 pro-apoptotic tumor suppressor is mutated or functionally altered in most cancers. In epithelial tumors induced by “high-risk” mucosal Human Papillomaviruses (hrm-HPVs), including human cervical carcinoma and a growing number of head-and-neck cancers 1, p53 is degraded by the viral oncoprotein E6 2. In this process, E6 binds to a short LxxLL consensus sequence within the cellular ubiquitin ligase E6AP 3. Subsequently, the E6/E6AP heterodimer recruits and degrades p53 4. Neither E6 nor E6AP are separately able to recruit p53 3,5, and the precise mode of assembly of E6, E6AP and p53 is unknown. Here, we solved the crystal structure of a ternary complex comprising full-length HPV16 E6, the LxxLL motif of E6AP and the core domain of p53. The LxxLL motif of E6AP renders the conformation of E6 competent for interaction with p53 by structuring a p53-binding cleft on E6. Mutagenesis of critical positions at the E6-p53 interface disrupts p53 degradation. The E6-binding site of p53 is distal from previously described DNA- and protein-binding surfaces of the core domain. This suggests that, in principle, E6 may avoid competition with cellular factors by targeting both free and bound p53 molecules. The E6/E6AP/p53 complex represents a prototype of viral hijacking of both the ubiquitin-mediated protein degradation pathway and the p53 tumor suppressor pathway. The present structure provides a framework for the design of inhibitory therapeutic strategies against HPV-mediated oncogenesis. PMID:26789255

Comparison of expression and enzymatic properties of Aspergillus oryzae lysine aminopeptidases ApsA and ApsB.

PubMed

Marui, Junichiro; Matsushita-Morita, Mayumi; Tada, Sawaki; Hattori, Ryota; Suzuki, Satoshi; Amano, Hitoshi; Ishida, Hiroki; Yamagata, Youhei; Takeuchi, Michio; Kusumoto, Ken-Ichi

2012-08-01

The apsA and apsB genes encoding family M1 aminopeptidases were identified in the industrial fungus Aspergillus oryzae. The apsB was transcriptionally up-regulated up to 2.5-fold in response to the deprivation of nitrogen or carbon sources in growth media, while up-regulation of apsA was less significant. The encoded proteins were bacterially expressed and purified to characterize their enzymatic properties. ApsA and ApsB were optimally active at pH 7.0 and 35 °C and stable at pH ranges of 6-10 and 4-10, respectively, up to 40 °C. The enzymes were inhibited by bestatin and EDTA, as has been reported for family M1 aminopeptidases that characteristically contain a zinc-binding catalytic motif. Both enzymes preferentially liberated N-terminal lysine, which is an essential amino acid and an important additive to animal feed. Enzymes that efficiently release N-terminal lysine from peptides could be useful for food and forage industries. Examination of the reactivity toward peptide substrate of varying length revealed that ApsB exhibited broader substrate specificity than ApsA although the reactivity of ApsB decreased as the length of peptide substrate decreased.

75 FR 74608 - Airworthiness Directives; CENTRAIR Models 101, 101A, 101P, and 101AP Gliders

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... Airworthiness Directives; CENTRAIR Models 101, 101A, 101P, and 101AP Gliders AGENCY: Federal Aviation...[eacute] Nouvelle (SN) Centrair. This tube had been reinforced in 1984 with a modification. Gliders...[eacute] Nouvelle (SN) Centrair. This tube had been reinforced in 1984 with a modification. Gliders...

75 FR 60421 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2010-OS-0130] Proposed Collection; Comment Request AGENCY: Office of the Under Secretary of Defense (Personnel and Readiness), DoD. ACTION... Federal Register Liaison Officer, Department of Defense. [FR Doc. 2010-24525 Filed 9-29-10; 8:45 am...

Novel fluorescent labelled affinity probes for diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A)-binding studies.

PubMed

Wright, Michael; Miller, Andrew D

2006-02-15

Tandem synthetic-biosynthetic procedures were used to prepare two novel fluorescent labelled affinity probes for diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A)-binding studies. These compounds (dial-mant-Ap4A and azido-mant-Ap4A) are shown to clearly distinguish known Ap4A-binding proteins from Escherichia coli (LysU and GroEL) and a variety of other control proteins. Successful labelling of chaperonin GroEL appears to be allosteric with respect to the well-characterized adenosine 5'-triphosphate (ATP)-binding site, suggesting that GroEL possesses a distinct Ap4A-binding site.

Building a world-class A/P function: how UPMC went paperless.

PubMed

DeLuca, Michael; Smith, Corey

2010-03-01

UPMC engaged people, processes, and technology to move its A/P function from a highly manual, paper-based operation to a completely automated process. UPMC's CFO hired a chief supply chain officer to develop a strategic plan, and UPMC named a value analysis team to gain clinician buy-in. UPMC automated A/P by enabling receipt of electronic invoices. UPMC streamlined its processes for invoices.

77 FR 25499 - Notice of Proposed Information Collection: Comment Request; Personal Financial and Credit Statement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5607-N-14] Notice of Proposed Information Collection: Comment Request; Personal Financial and Credit Statement AGENCY: Office of the... Proposal: Personal Financial and Credit Statement. OMB Control Number, if applicable: 2502-0001...

75 FR 5779 - Proposed Emergency Agency Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... proposed collection of information, including the validity of the methodology and assumptions used; (c... Collection Request Title: Electricity Delivery and Energy Reliability Recovery Act Smart Grid Grant Program..., Chief Operating Officer, Electricity Delivery and Energy Reliability. [FR Doc. 2010-2422 Filed 2-3-10; 8...

Mathematical modeling of high-pH chemical flooding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhuyan, D.; Lake, L.W.; Pope, G.A.

1990-05-01

This paper describes a generalized compositional reservoir simulator for high-pH chemical flooding processes. This simulator combines the reaction chemistry associated with these processes with the extensive physical- and flow-property modeling schemes of an existing micellar/polymer flood simulator, UTCHEM. Application of the model is illustrated for cases from a simple alkaline preflush to surfactant-enhanced alkaline-polymer flooding.

10 CFR 1045.20 - Ongoing call for declassification proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... from the public or agencies or contractors for declassification of RD and FRD information on an ongoing basis. Declassification proposals for RD and FRD information shall be forwarded to the Chief Health... declassification proposals for FRD information. [62 FR 68509, Dec. 31, 1997, as amended at 71 FR 68737, Nov. 28...

10 CFR 1045.20 - Ongoing call for declassification proposals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... from the public or agencies or contractors for declassification of RD and FRD information on an ongoing basis. Declassification proposals for RD and FRD information shall be forwarded to the Chief Health... declassification proposals for FRD information. [62 FR 68509, Dec. 31, 1997, as amended at 71 FR 68737, Nov. 28...

10 CFR 1045.20 - Ongoing call for declassification proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... from the public or agencies or contractors for declassification of RD and FRD information on an ongoing basis. Declassification proposals for RD and FRD information shall be forwarded to the Chief Health... declassification proposals for FRD information. [62 FR 68509, Dec. 31, 1997, as amended at 71 FR 68737, Nov. 28...

10 CFR 1045.20 - Ongoing call for declassification proposals.

Code of Federal Regulations, 2013 CFR

2013-01-01

... from the public or agencies or contractors for declassification of RD and FRD information on an ongoing basis. Declassification proposals for RD and FRD information shall be forwarded to the Chief Health... declassification proposals for FRD information. [62 FR 68509, Dec. 31, 1997, as amended at 71 FR 68737, Nov. 28...

10 CFR 1045.20 - Ongoing call for declassification proposals.

Code of Federal Regulations, 2012 CFR

2012-01-01

... from the public or agencies or contractors for declassification of RD and FRD information on an ongoing basis. Declassification proposals for RD and FRD information shall be forwarded to the Chief Health... declassification proposals for FRD information. [62 FR 68509, Dec. 31, 1997, as amended at 71 FR 68737, Nov. 28...

Introduction to SNPP/VIIRS Flood Mapping Software Version 1.0

NASA Astrophysics Data System (ADS)

Li, S.; Sun, D.; Goldberg, M.; Sjoberg, W.; Santek, D.; Hoffman, J.

2017-12-01

Near real-time satellite-derived flood maps are invaluable to river forecasters and decision-makers for disaster monitoring and relief efforts. With support from the JPSS (Joint Polar Satellite System) Proving Ground and Risk Reduction (PGRR) Program, flood detection software has been developed using Suomi-NPP/VIIRS (Suomi National Polar-orbiting Partnership/Visible Infrared Imaging Radiometer Suite) imagery to automatically generate near real-time flood maps for National Weather Service (NWS) River Forecast Centers (RFC) in the USA. The software, which is called VIIRS NOAA GMU Flood Version 1.0 (hereafter referred to as VNG Flood V1.0), consists of a series of algorithms that include water detection, cloud shadow removal, terrain shadow removal, minor flood detection, water fraction retrieval, and floodwater determination. The software is designed for flood detection in any land region between 80°S and 80°N, and it has been running routinely with direct broadcast SNPP/VIIRS data at the Space Science and Engineering Center at the University of Wisconsin-Madison (UW/SSEC) and the Geographic Information Network of Alaska at the University of Alaska-Fairbanks (UAF/GINA) since 2014. Near real-time flood maps are distributed via the Unidata Local Data Manager (LDM), reviewed by river forecasters in AWIPS-II (the second generation of the Advanced Weather Interactive Processing System) and applied in flood operations. Initial feedback from operational forecasters on the product accuracy and performance has been largely positive. The software capability has also been extended to areas outside of the USA via a case-driven mode to detect major floods all over the world. Offline validation efforts include the visual inspection of over 10,000 VIIRS false-color composite images, an inter-comparison with MODIS automatic flood products and a quantitative evaluation using Landsat imagery. The steady performance from the 3-year routine process and the promising validation results

Flood Plain Information, Buffalo Creek, New York in the Towns of Elma and West Seneca. Main Report and Technical Appendix.

DTIC Science & Technology

1971-06-01

addition to Elma Methodist Church showing comparative flood lev-ls. 14 27. Home on Winspear Road near mile 7.4, 36 raised 5 feet in 1963. 28. Supermarket ...and other local governrient ?gencies. "hr flooded outlines, profiles -nd -stimntrd flood fr-quenciee can b- uFsd to deter- mine the relative risk of...7rovisions hich re.rlite the us- of land with resect to flood risk . The General Provis ons of the 2onin- Ordinance of W4st "eneca do indicate that te

The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1.

PubMed Central

Diccianni, M B; Imagawa, M; Muramatsu, M

1992-01-01

Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE). GPEI is active in AP1-lacking F9 cells as well in AP1-containing HeLa cells. Despite GPEI's similarity to a TRE, c-jun co-transfection has only a minimal effect on transactivation. Antisense c-jun and c-fos co-transfection experiments further demonstrate the lack of a role for AP1 in GPEI mediated trans-activation in F9 cells, although endogenously present AP1 can influence GPEI in HeLa cells. Co-transfection of delta fosB with c-jun, which forms an inactive c-Jun/delta FosB heterodimer that binds TRE sequences, inhibits GPEI-mediated transcription in AP1-lacking F9 cells as well as AP1-containing HeLa cells. These data suggest novel factor(s) other than AP1 are influencing GPEI. Binding studies reveal multiple nucleoproteins bind to GPEI. These factors are likely responsible for the high level of GPEI-mediated transcription observed in the absence of AP1 and during hepatocarcinogenesis. Images PMID:1408831

The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1.

PubMed

Diccianni, M B; Imagawa, M; Muramatsu, M

1992-10-11

Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE). GPEI is active in AP1-lacking F9 cells as well in AP1-containing HeLa cells. Despite GPEI's similarity to a TRE, c-jun co-transfection has only a minimal effect on transactivation. Antisense c-jun and c-fos co-transfection experiments further demonstrate the lack of a role for AP1 in GPEI mediated trans-activation in F9 cells, although endogenously present AP1 can influence GPEI in HeLa cells. Co-transfection of delta fosB with c-jun, which forms an inactive c-Jun/delta FosB heterodimer that binds TRE sequences, inhibits GPEI-mediated transcription in AP1-lacking F9 cells as well as AP1-containing HeLa cells. These data suggest novel factor(s) other than AP1 are influencing GPEI. Binding studies reveal multiple nucleoproteins bind to GPEI. These factors are likely responsible for the high level of GPEI-mediated transcription observed in the absence of AP1 and during hepatocarcinogenesis.

17 CFR 240.14d-10 - Equal treatment of security holders.

Code of Federal Regulations, 2010 CFR

2010-04-01

...: (1) Affect dissemination under Rule 14d-4 (§ 240.14d-4); or (2) Prohibit a bidder from making a... protection of investors. [51 FR 25882, July 17, 1986, as amended at 71 FR 65408, Nov. 8, 2006] ...

Floods in Central Texas, September 7-14, 2010

USGS Publications Warehouse

Winters, Karl E.

2012-01-01

Severe flooding occurred near the Austin metropolitan area in central Texas September 7–14, 2010, because of heavy rainfall associated with Tropical Storm Hermine. The U.S. Geological Survey, in cooperation with the Upper Brushy Creek Water Control and Improvement District, determined rainfall amounts and annual exceedance probabilities for rainfall resulting in flooding in Bell, Williamson, and Travis counties in central Texas during September 2010. We documented peak streamflows and the annual exceedance probabilities for peak streamflows recorded at several streamflow-gaging stations in the study area. The 24-hour rainfall total exceeded 12 inches at some locations, with one report of 14.57 inches at Lake Georgetown. Rainfall probabilities were estimated using previously published depth-duration frequency maps for Texas. At 4 sites in Williamson County, the 24-hour rainfall had an annual exceedance probability of 0.002. Streamflow measurement data and flood-peak data from U.S. Geological Survey surface-water monitoring stations (streamflow and reservoir gaging stations) are presented, along with a comparison of September 2010 flood peaks to previous known maximums in the periods of record. Annual exceedance probabilities for peak streamflow were computed for 20 streamflow-gaging stations based on an analysis of streamflow-gaging station records. The annual exceedance probability was 0.03 for the September 2010 peak streamflow at the Geological Survey's streamflow-gaging stations 08104700 North Fork San Gabriel River near Georgetown, Texas, and 08154700 Bull Creek at Loop 360 near Austin, Texas. The annual exceedance probability was 0.02 for the peak streamflow for Geological Survey's streamflow-gaging station 08104500 Little River near Little River, Texas. The lack of similarity in the annual exceedance probabilities computed for precipitation and streamflow might be attributed to the small areal extent of the heaviest rainfall over these and the other gaged

Ca(2+)-stores mobilization by diadenosine tetraphosphate, Ap4A, through a putative P2Y purinoceptor in adrenal chromaffin cells.

PubMed Central

Castro, E.; Pintor, J.; Miras-Portugal, M. T.

1992-01-01

1. Diadenosine tetraphosphate (Ap4A) evoked a concentration-dependent increase in cytosolic [Ca2+] in resting chromaffin cells. The EC50 value for this action was 28.2 +/- 6.6 microM. This effect was also produced by diadenosine pentaphosphate (Ap5A) with an EC50 of 50 +/- 7 microM. 2. In contrast with this effect, pretreatment with Ap4A or Ap5A induced a 30% reduction in Ca2+ entry following 10 microM dimethylphenylpiperazinium. 3. The elevation in cytosolic [Ca2+] induced by Ap4A was persistent in approximately 100 nM external [Ca2+] and was sensitive to depletion of internal Ca2+ stores by a bradykinin prepulse or whole cell depletion in Ca2+. 4. The effect of Ap4A was mimicked and desensitized by the agonist adenosine 5'-O-(2-thiodiphosphate), and blocked by the P2Y-receptor antagonist, cibachrome blue. The P2X-receptor agonist alpha,beta-methylene adenosine 5'-triphosphate was inactive both by itself or in combination with Ap4A. This is compatible with a P2Y-purinoceptor-mediated action. PMID:1393282

Ca(2+)-stores mobilization by diadenosine tetraphosphate, Ap4A, through a putative P2Y purinoceptor in adrenal chromaffin cells.

PubMed

Castro, E; Pintor, J; Miras-Portugal, M T

1992-08-01

1. Diadenosine tetraphosphate (Ap4A) evoked a concentration-dependent increase in cytosolic [Ca2+] in resting chromaffin cells. The EC50 value for this action was 28.2 +/- 6.6 microM. This effect was also produced by diadenosine pentaphosphate (Ap5A) with an EC50 of 50 +/- 7 microM. 2. In contrast with this effect, pretreatment with Ap4A or Ap5A induced a 30% reduction in Ca2+ entry following 10 microM dimethylphenylpiperazinium. 3. The elevation in cytosolic [Ca2+] induced by Ap4A was persistent in approximately 100 nM external [Ca2+] and was sensitive to depletion of internal Ca2+ stores by a bradykinin prepulse or whole cell depletion in Ca2+. 4. The effect of Ap4A was mimicked and desensitized by the agonist adenosine 5'-O-(2-thiodiphosphate), and blocked by the P2Y-receptor antagonist, cibachrome blue. The P2X-receptor agonist alpha,beta-methylene adenosine 5'-triphosphate was inactive both by itself or in combination with Ap4A. This is compatible with a P2Y-purinoceptor-mediated action.

PAI-OFF: A new proposal for online flood forecasting in flash flood prone catchments

NASA Astrophysics Data System (ADS)

Schmitz, G. H.; Cullmann, J.

2008-10-01

SummaryThe Process Modelling and Artificial Intelligence for Online Flood Forecasting (PAI-OFF) methodology combines the reliability of physically based, hydrologic/hydraulic modelling with the operational advantages of artificial intelligence. These operational advantages are extremely low computation times and straightforward operation. The basic principle of the methodology is to portray process models by means of ANN. We propose to train ANN flood forecasting models with synthetic data that reflects the possible range of storm events. To this end, establishing PAI-OFF requires first setting up a physically based hydrologic model of the considered catchment and - optionally, if backwater effects have a significant impact on the flow regime - a hydrodynamic flood routing model of the river reach in question. Both models are subsequently used for simulating all meaningful and flood relevant storm scenarios which are obtained from a catchment specific meteorological data analysis. This provides a database of corresponding input/output vectors which is then completed by generally available hydrological and meteorological data for characterizing the catchment state prior to each storm event. This database subsequently serves for training both a polynomial neural network (PoNN) - portraying the rainfall-runoff process - and a multilayer neural network (MLFN), which mirrors the hydrodynamic flood wave propagation in the river. These two ANN models replace the hydrological and hydrodynamic model in the operational mode. After presenting the theory, we apply PAI-OFF - essentially consisting of the coupled "hydrologic" PoNN and "hydrodynamic" MLFN - to the Freiberger Mulde catchment in the Erzgebirge (Ore-mountains) in East Germany (3000 km 2). Both the demonstrated computational efficiency and the prediction reliability underline the potential of the new PAI-OFF methodology for online flood forecasting.

APS Science 2009.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibson, J. M; Mills, D. M.; Gerig, R.

It is my pleasure to introduce the 2009 annual report of the Advanced Photon Source. This was a very good year for us. We operated with high reliability and availability, despite growing problems with obsolete systems, and our users produced a record output of publications. The number of user experiments increased by 14% from 2008 to more than 3600. We congratulate the recipients of the 2009 Nobel Prize in Chemistry-Venkatraman Ramakrishnan (Cambridge Institute for Medical Research), Thomas Steitz (Yale University), and Ada Yonath (Weizmann Institute) - who did a substantial amount of this work at APS beamlines. Thanks to themore » efforts of our users and staff, and the ongoing counsel of the APS Scientific Advisory Committee, we made major progress in advancing our planning for the upgrade of the APS (APS-U), producing a proposal that was positively reviewed. We hope to get formal approval in 2010 to begin the upgrade. With advocacy from our users and the support of our sponsor, the Office of Basic Energy Sciences in the Department of Energy (DOE) Office of Science, our operating budgets have grown to the level needed to more adequately staff our beamlines. We were also extremely fortunate to have received $7.9 M in American Recovery and Reinvestment Act ('stimulus') funding to acquire new detectors and improve several of our beamlines. The success of the new Linac Coherent Light Source at Stanford, the world's first x-ray free-electron laser, made us particularly proud since the undulators were designed and built by the APS. Among other highlights, we note that more than one-quarter of the 46 Energy Frontier Research Centers, funded competitively across the U.S. in 2009 by the DOE, included the Advanced Photon Source in their proposed work, which shows that synchrotron radiation, and the APS in particular, are central to energy research. While APS research covers everything from fundamental to applied science (reflected by the highlights in this report), the

10 CFR 51.14 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Definitions. 51.14 Section 51.14 Energy NUCLEAR REGULATORY... respect to any environmental impact involved in a proposal (or a reasonable alternative) for legislation... Environmental Quality (CEQ) established by Title II of NEPA. DOE means the U.S. Department of Energy or its duly...

10 CFR 51.14 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Definitions. 51.14 Section 51.14 Energy NUCLEAR REGULATORY... respect to any environmental impact involved in a proposal (or a reasonable alternative) for legislation... Environmental Quality (CEQ) established by Title II of NEPA. DOE means the U.S. Department of Energy or its duly...

75 FR 21370 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

... public comment on new or revised data collections, the Railroad Retirement Board (RRB) will publish... Charles[email protected] . Comments regarding the information collection should be addressed to Patricia A.... Charles Mierzwa, Clearance Officer. [FR Doc. 2010-9435 Filed 4-22-10; 8:45 am] BILLING CODE 7905-01-P ...

76 FR 67784 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Order Approving Proposed Rule Change To...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-02

... connection with this reclassification, the Exchange has proposed certain voting rights,\\4\\ transfer... Securities Exchange Act of 1934 (``Act''),\\1\\ and Rule 19b-4 thereunder,\\2\\ a proposed rule change to amend... Exchange Act Release No. 65299 (September 8, 2011), 76 FR 56833 (September 14, 2011) (``Notice''). II...

76 FR 62148 - Title VI; Proposed Circular, Environmental Justice; Proposed Circular

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

...-0055] Title VI; Proposed Circular, Environmental Justice; Proposed Circular AGENCY: Federal Transit... the September 29, 2011, Federal Register Notices titled ``Title VI; Proposed Circular'' and... September 29, 2011, Federal Register Notices titled ``Title VI; Proposed Circular'' (76 FR 60593) and...

76 FR 72627 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

.... confluence with Black Fox Run. Approximately 480 feet +868 upstream of State Route 368. Allegheny River... Assistance No. 97.022, ``Flood Insurance.'' Dated: November 14, 2011. Sandra K. Knight, Deputy Associate...

78 FR 45936 - Agency Information Collection Activities: Proposed Collection; Comment Request; National Flood...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

... establish by regulation an additional process for the appeal of decisions of flood insurance claims issued... informal process to handle appeals regarding decisions related to coverage, or claims under the NFIP... to the flood insurance claims process. DATES: Comments must be submitted on or before September 30...

FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2.

PubMed

Steen, Kaylee A; Xu, Hongliang; Bernlohr, David A

2017-01-15

Obesity-linked metabolic disease is mechanistically associated with the accumulation of proinflammatory macrophages in adipose tissue, leading to increased reactive oxygen species (ROS) production and chronic low-grade inflammation. Previous work has demonstrated that deletion of the adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via upregulation of the uncoupling protein 2 (UCP2). Here, we demonstrate that ablation of FABP4/aP2 regulates systemic redox capacity and reduces cellular protein sulfhydryl oxidation and, in particular, oxidation of mitochondrial protein cysteine residues. Coincident with the loss of FABP4/aP2 is the upregulation of the antioxidants superoxide dismutase (SOD2), catalase, methionine sulfoxide reductase A, and the 20S proteasome subunits PSMB5 and αβ. Reduced mitochondrial protein oxidation in FABP4/aP2 -/- macrophages attenuates the mitochondrial unfolded-protein response (mtUPR) as measured by expression of heat shock protein 60, Clp protease, and Lon peptidase 1. Consistent with a diminished mtUPR, FABP4/aP2 -/- macrophages exhibit reduced expression of cleaved caspase-1 and NLRP3. Secretion of interleukin 1β (IL-1β), in response to inflammasome activation, is ablated in FABP4/aP2 -/- macrophages, as well as in FABP4/aP2 inhibitor-treated cells, but partially rescued in FABP4/aP2-null macrophages when UCP2 is silenced. Collectively, these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression. Copyright © 2017 American Society for Microbiology.

77 FR 23270 - Agency Information Collection Activities: Proposed Collection; Comment Request, National Flood...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... information collection that allows the National Flood Insurance Program (NFIP) to facilitate the availability of flood insurance to those who have a need to purchase such. The NFIP will collect information from... available by the NFIP would be adversely affected. DATES: Comments must be submitted on or before June 18...

77 FR 73097 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-07

... Exchange on the matter at issue. Retail Liquidity Identifier Under proposed Nasdaq Rule 4780(e), the... (January 14, 2010), 75 FR 3594 (January 21, 2010) (noting that dark pools and internalizing broker- dealers...

10 CFR 61.14 - Institutional information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Institutional information. 61.14 Section 61.14 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE... proposed disposal site is on land not owned by the Federal or a State government, the applicant must submit...

10 CFR 61.14 - Institutional information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Institutional information. 61.14 Section 61.14 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE... proposed disposal site is on land not owned by the Federal or a State government, the applicant must submit...

10 CFR 61.14 - Institutional information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Institutional information. 61.14 Section 61.14 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE... proposed disposal site is on land not owned by the Federal or a State government, the applicant must submit...

10 CFR 61.14 - Institutional information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Institutional information. 61.14 Section 61.14 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE... proposed disposal site is on land not owned by the Federal or a State government, the applicant must submit...

10 CFR 61.14 - Institutional information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Institutional information. 61.14 Section 61.14 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE... proposed disposal site is on land not owned by the Federal or a State government, the applicant must submit...

10. VIEW OF THE SOUTH ELEVATION AND THE FLOOD GATE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. VIEW OF THE SOUTH ELEVATION AND THE FLOOD GATE ON THE PRESSURE CULVERT, LOOKING NORTH. - Wyoming Valley Flood Control System, Woodward Pumping Station, East of Toby Creek crossing by Erie-Lackawanna Railroad, Edwardsville, Luzerne County, PA

Characterization of diadenosine tetraphosphate (Ap4A) binding sites in cultured chromaffin cells: evidence for a P2y site.

PubMed Central

Pintor, J.; Torres, M.; Castro, E.; Miras-Portugal, M. T.

1991-01-01

1. Diadenosine tetraphosphate (Ap4A) a dinucleotide, which is stored in secretory granules, presents two types of high affinity binding sites in chromaffin cells. A Kd value of 8 +/- 0.65 x 10(-11) M and Bmax value of 5420 +/- 450 sites per cell were obtained for the high affinity binding site. A Kd value of 5.6 +/- 0.53 x 10(-9) M and a Bmax value close to 70,000 sites per cell were obtained for the second binding site with high affinity. 2. The diadenosine polyphosphates, Ap3A, Ap4A, Ap5A and Ap6A, displaced [3H]-Ap4A from the two binding sites, the Ki values being 1.0 nM, 0.013 nM, 0.013 nM and 0.013 nM for the very high affinity binding site and 0.5 microM, 0.13 microM, 0.062 microM and 0.75 microM for the second binding site. 3. The ATP analogues displaced [3H]-Ap4A with the potency order of the P2y receptors, adenosine 5'-O-(2 thiodiphosphate) (ADP-beta-S) greater than 5'-adenylyl imidodiphosphate (AMP-PNP) greater than alpha, beta-methylene ATP (alpha, beta-MeATP), in both binding sites. The Ki values were respectively 0.075 nM, 0.2 nM and 0.75 nM for the very high affinity binding site and 0.125 microM, 0.5 microM and 0.9 microM for the second binding site. PMID:1912985

Bilateral comparison of 10 pF and 100 pF standards (ongoing BIPM key comparisons BIPM.EM-K14.a and 14.b) between the NIS (Egypt) and the BIPM

NASA Astrophysics Data System (ADS)

Gournay, Pierre; Helmy, M.; Raouf, A.; Hamed, Heba A. M.; Eliwa Gad, A.

2017-01-01

This report presents the results of a bilateral comparison of 10 pF and 100 pF capacitance standards between the NIS (Egypt) and the BIPM carried out in 2016. The comparison at 10 pF forms part of the ongoing BIPM key comparison BIPM.EM-K14.a and that at 100 pF of the ongoing BIPM key comparison BIPM.EM-K14.b. The BIPM is the pilot laboratory for both of these comparisons. Two 10 pF and 100 pF travelling standards belonging to the BIPM were used in this comparison carried out with an 'A-B-A' pattern of measurements. The standards were measured first at the BIPM for a period of about one month, then for a similar period at the NIS, and finally again at the BIPM. The measurand was the two terminal-pair capacitance at a frequency of either 1000 Hz or 1592 Hz, for a measuring rms voltage of 15 V at 10 pF and 10 V at 100 pF. One of the 10 pF travelling standards had to be eliminated from the comparison due to a bistable behaviour, possibly due to transportation. The results from the NIS and the BIPM at both 1000 Hz and 1592 Hz were found to be in good agreement, with a difference smaller than the relative expanded uncertainty (95 % confidence, k = 2) of about 0.72 × 10-6 at 10 pF and about 0.65 × 10-6 at 100 pF. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

Staging of chronic myeloid leukemia in the imatinib era: an evaluation of the World Health Organization proposal.

PubMed

Cortes, Jorge E; Talpaz, Moshe; O'Brien, Susan; Faderl, Stefan; Garcia-Manero, Guillermo; Ferrajoli, Alessandra; Verstovsek, Srdan; Rios, Mary B; Shan, Jenny; Kantarjian, Hagop M

2006-03-15

Several staging classification systems, all of which were designed in the preimatinib era, are used for chronic myeloid leukemia (CML). The World Health Organization (WHO) recently proposed a new classification system that has not been validated clinically. The authors investigated the significance of the WHO classification system and compared it with the classification systems used to date in imatinib trials ("standard definition") to determine its impact in establishing the outcome of patients after therapy with imatinib. In total, 809 patients who received imatinib for CML were classified into chronic phase (CP), accelerated phase (AP), and blast phase (BP) based on standard definitions and then were reclassified according to the new WHO classification system. Their outcomes with imatinib therapy were compared, and the value of individual components of these classification systems was determined. With the WHO classification, 78 patients (10%) were reclassified: 45 patients (6%) were reclassified from CP to AP, 14 patients (2%) were reclassified from AP to CP, and 19 patients (2%) were reclassified from AP to BP. The rates of complete cytogenetic response for patients in CP, AP, and BP according to the standard definition were 72%, 45%, and 8%, respectively. After these patients were reclassified according to WHO criteria, the response rates were 77% (P = 0.07), 39% (P = 0.28), and 11% (P = 0.61), respectively. The 3-year survival rates were 91%, 65%, and 10%, respectively, according to the standard classification and 95% (P = 0.05), 63% (P = 0.76), and 16% (P = 0.18), respectively, according to the WHO classification. Patients who had a blast percentage of 20-29%, which is considered CML-BP according to the WHO classification, had a significantly better response rate (21% vs. 8%; P = 0.11) and 3-year survival rate (42% vs. 10%; P = 0.0001) compared with patients who had blasts > or = 30%. Different classification systems had an impact on the outcome of patients

Modeling the Historical Flood Events in France

NASA Astrophysics Data System (ADS)

Ali, Hani; Blaquière, Simon

2017-04-01

We will present the simulation results for different scenarios based on the flood model developed by AXA Global P&C CAT Modeling team. The model uses a Digital Elevation Model (DEM) with 75 m resolution, a hydrographic system (DB Carthage), daily rainfall data from "Météo France", water level from "HYDRO Banque" the French Hydrological Database (www.hydro.eaufrance.fr), for more than 1500 stations, hydrological model from IRSTEA and in-house hydraulic tool. In particular, the model re-simulates the most important and costly flood events that occurred during the past decade in France: we will present the re-simulated meteorological conditions since 1964 and estimate insurance loss incurred on current AXA portfolio of individual risks.

77 FR 21592 - Proposal Review Panel for Materials Research; Notice of Meeting: Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-10

... 19362, column 3, line 3, please replace: ``7 p.m.-8:30p.m. Open-Poster Session'' with ``7 p.m.-10:30p.m. Open-Poster Session''. Dated: April 5, 2012. Susanne Bolton, Committee Management Officer. [FR Doc...

5',5'''-P1, P4 diadenosine tetraphosphate (Ap4A): a putative initiator of DNA replication.

PubMed

Baril, E F; Coughlin, S A; Zamecnik, P C

1985-01-01

The proposal that Ap4A acts as an inducer of DNA replication is based primarily on two pieces of evidence (7). The intracellular levels of Ap4A increase ten- to 1000-fold as cells progress into S phase and the introduction of Ap4A into nonproliferating cells stimulated DNA synthesis. There is also some additional suggestive evidence such as the binding of Ap4A to a protein that is associated with multiprotein forms of the replicative DNA polymerase alpha and the ability of this enzyme to use Ap4A as a primer for DNA synthesis in vitro with single-stranded DNA templates. These observations have stimulated interest in the cellular metabolism of Ap4A. This is well since there is a great need for additional experimentation in order to clearly establish Ap4A as an inducer of DNA replication. Microinjection experiments of Ap4A into quiescent cells are needed in order to ascertain if Ap4A will stimulate DNA replication and possibly cell division in intact cells. Studies of the effects of nonhydrolyzable analogs of Ap4A on DNA replication in intact quiescent cells could also prove valuable. Although Ap4A can function as a primer for in vitro DNA synthesis by DNA polymerase alpha this may not be relevant in regard to its in vivo role in DNA replication. Ap4A in vivo could interact with key protein(s) in DNA replication and in this way act as an effector molecule in the initiation of DNA replication. In this regard the interaction of Ap4A with a protein associated with a multiprotein form of DNA polymerase alpha isolated from S-phase cells is of interest. More experiments are required to determine if there is a specific target protein(s) for Ap4A in vivo and what its role in DNA replication is. The cofractionation of tryptophanyl-tRNA synthetase with the replicative DNA polymerase alpha from animal and plant cells is of interest. The DNA polymerase alpha from synchronized animal cells also interacted with Ap4A. Although the plant cell alpha-like DNA polymerase did not

P4-ATPase Requirement for AP-1/Clathrin Function in Protein Transport from the trans-Golgi Network and Early Endosomes

PubMed Central

Liu, Ke; Surendhran, Kavitha; Nothwehr, Steven F.

2008-01-01

Drs2p is a resident type 4 P-type ATPase (P4-ATPase) and potential phospholipid translocase of the trans-Golgi network (TGN) where it has been implicated in clathrin function. However, precise protein transport pathways requiring Drs2p and how it contributes to clathrin-coated vesicle budding remain unclear. Here we show a functional codependence between Drs2p and the AP-1 clathrin adaptor in protein sorting at the TGN and early endosomes of Saccharomyces cerevisiae. Genetic criteria indicate that Drs2p and AP-1 operate in the same pathway and that AP-1 requires Drs2p for function. In addition, we show that loss of AP-1 markedly increases Drs2p trafficking to the plasma membrane, but does not perturb retrieval of Drs2p from the early endosome back to the TGN. Thus AP-1 is required at the TGN to sort Drs2p out of the exocytic pathway, presumably for delivery to the early endosome. Moreover, a conditional allele that inactivates Drs2p phospholipid translocase (flippase) activity disrupts its own transport in this AP-1 pathway. Drs2p physically interacts with AP-1; however, AP-1 and clathrin are both recruited normally to the TGN in drs2Δ cells. These results imply that Drs2p acts independently of coat recruitment to facilitate AP-1/clathrin-coated vesicle budding from the TGN. PMID:18508916

77 FR 53242 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... Exchange on the matter at issue. Retail Liquidity Identifier Under proposed Rule 11.24(e), the Exchange... Exchange Act Release No. 61358 (January 14, 2010), 75 FR 3594 (January 21, 2010) (noting that dark pools...

44 CFR 78.14 - Alternative procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Alternative procedures. 78.14 Section 78.14 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION...

44 CFR 78.14 - Alternative procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Alternative procedures. 78.14 Section 78.14 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION...

44 CFR 78.14 - Alternative procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Alternative procedures. 78.14 Section 78.14 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION...

44 CFR 78.14 - Alternative procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Alternative procedures. 78.14 Section 78.14 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION...

44 CFR 78.14 - Alternative procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Alternative procedures. 78.14 Section 78.14 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION...

Overexpression of two PsnAP1 genes from Populus simonii × P. nigra causes early flowering in transgenic tobacco and Arabidopsis.

PubMed

Zheng, Tangchun; Li, Shuang; Zang, Lina; Dai, Lijuan; Yang, Chuanping; Qu, Guan-Zheng

2014-01-01

In Arabidopsis, AP1 is a floral meristem identity gene and plays an important role in floral organ development. In this study, PsnAP1-1 and PsnAP1-2 were isolated from the male reproductive buds of poplar (Populus simonii × P. nigra), which are the orthologs of AP1 in Arabidopsis, by sequence analysis. Northern blot and qRT-PCR analysis showed that PsnAP1-1 and PsnAP1-2 exhibited high expression level in early inflorescence development of poplar. Subcellular localization showed the PsnAP1-1 and PsnAP1-2 proteins are localized in the nucleus. Overexpression of PsnAP1-1 and PsnAP1-2 in tobacco under the control of a CaMV 35S promoter significantly enhanced early flowering. These transgenic plants also showed much earlier stem initiation and higher rates of photosynthesis than did wild-type tobacco. qRT-PCR analysis further indicated that overexpression of PsnAP1-1 and PsnAP1-2 resulted in up-regulation of genes related to flowering, such as NtMADS4, NtMADS5 and NtMADS11. Overexpression of PsnAP1-1 and PsnAP1-2 in Arabidopsis also induced early flowering, but did not complement the ap1-10 floral morphology to any noticeable extent. This study indicates that PsnAP1-1 and PsnAP1-2 play a role in floral transition of poplar.

Overexpression of Two PsnAP1 Genes from Populus simonii × P. nigra Causes Early Flowering in Transgenic Tobacco and Arabidopsis

PubMed Central

Zheng, Tangchun; Li, Shuang; Zang, Lina; Dai, Lijuan; Yang, Chuanping; Qu, Guan-Zheng

2014-01-01

In Arabidopsis, AP1 is a floral meristem identity gene and plays an important role in floral organ development. In this study, PsnAP1-1 and PsnAP1-2 were isolated from the male reproductive buds of poplar (Populus simonii × P. nigra), which are the orthologs of AP1 in Arabidopsis, by sequence analysis. Northern blot and qRT-PCR analysis showed that PsnAP1-1 and PsnAP1-2 exhibited high expression level in early inflorescence development of poplar. Subcellular localization showed the PsnAP1-1 and PsnAP1-2 proteins are localized in the nucleus. Overexpression of PsnAP1-1 and PsnAP1-2 in tobacco under the control of a CaMV 35S promoter significantly enhanced early flowering. These transgenic plants also showed much earlier stem initiation and higher rates of photosynthesis than did wild-type tobacco. qRT-PCR analysis further indicated that overexpression of PsnAP1-1 and PsnAP1-2 resulted in up-regulation of genes related to flowering, such as NtMADS4, NtMADS5 and NtMADS11. Overexpression of PsnAP1-1 and PsnAP1-2 in Arabidopsis also induced early flowering, but did not complement the ap1-10 floral morphology to any noticeable extent. This study indicates that PsnAP1-1 and PsnAP1-2 play a role in floral transition of poplar. PMID:25360739

76 FR 49769 - Proposed Agency Information Collection Activities; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-11

... partner or limited partner, (4) adding event types to the 4(k) schedule, (5) requiring the reporting of...: FR Y-10, FR Y-6, and FR Y-7. OMB control number: 7100-0297. Frequency: FR Y-10: Event-generated; FR Y... an event generated information collection submitted by FBOs; top-tier BHCs; state member banks...

Bilateral comparison of 10 pF and 100 pF standards (ongoing BIPM key comparisons BIPM.EM-K14.a and 14.b) between the NMISA (South Africa) and the BIPM

NASA Astrophysics Data System (ADS)

Gournay, Pierre; Khoza, Michael

2017-01-01

This report presents the results of a bilateral comparison of 10 pF and 100 pF capacitance standards between the NMISA (South Africa) and the BIPM carried out in 2016. The comparison at 10 pF forms part of the ongoing BIPM key comparison BIPM.EM-K14.a and that at 100 pF of the ongoing BIPM key comparison BIPM.EM-K14.b. The BIPM is the pilot laboratory for both of these comparisons. Two 10 pF and 100 pF travelling standards belonging to the BIPM were used in this comparison carried out with an 'A-B-A' pattern of measurements. The standards were measured first at the BIPM for a period of about one month, then for a similar period at the NMISA, and finally again at the BIPM. The measurand was the two terminal-pair capacitance at a frequency of either 1000 Hz or 1592 Hz, for a measuring rms voltage of 15 V at 10 pF and 10 V at 100 pF. One of the 10 pF travelling standards had to be eliminated from the comparison due to a bistable behaviour, possibly due to transportation. The results from the NMISA and the BIPM at both 1000 Hz and 1592 Hz were found to be in good agreement, with a difference smaller than the relative expanded uncertainty (95 % confidence, k = 2) of maximum value 0.33 × 10-6 at 10 pF and 0.24 × 10-6 at 100 pF (and 1000 Hz in both cases). Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

7 CFR 3405.14 - Proposal review.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Proposal review. 3405.14 Section 3405.14 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Proposal Review and Evaluation § 3405.14 Proposal review. The proposal...

7 CFR 3405.14 - Proposal review.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Proposal review. 3405.14 Section 3405.14 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Proposal Review and Evaluation § 3405.14 Proposal review. The proposal...

7 CFR 3405.14 - Proposal review.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Proposal review. 3405.14 Section 3405.14 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Proposal Review and Evaluation § 3405.14 Proposal review. The proposal...

7 CFR 3405.14 - Proposal review.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Proposal review. 3405.14 Section 3405.14 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Proposal Review and Evaluation § 3405.14 Proposal review. The proposal...

Characteristics of the April 2007 Flood at 10 Streamflow-Gaging Stations in Massachusetts

USGS Publications Warehouse

Zarriello, Phillip J.; Carlson, Carl S.

2009-01-01

A large 'nor'easter' storm on April 15-18, 2007, brought heavy rains to the southern New England region that, coupled with normal seasonal high flows and associated wet soil-moisture conditions, caused extensive flooding in many parts of Massachusetts and neighboring states. To characterize the magnitude of the April 2007 flood, a peak-flow frequency analysis was undertaken at 10 selected streamflow-gaging stations in Massachusetts to determine the magnitude of flood flows at 5-, 10-, 25-, 50-, 100-, 200-, and 500-year return intervals. The magnitude of flood flows at various return intervals were determined from the logarithms of the annual peaks fit to a Pearson Type III probability distribution. Analysis included augmenting the station record with longer-term records from one or more nearby stations to provide a common period of comparison that includes notable floods in 1936, 1938, and 1955. The April 2007 peak flow was among the highest recorded or estimated since 1936, often ranking between the 3d and 5th highest peak for that period. In general, the peak-flow frequency analysis indicates the April 2007 peak flow has an estimated return interval between 25 and 50 years; at stations in the northeastern and central areas of the state, the storm was less severe resulting in flows with return intervals of about 5 and 10 years, respectively. At Merrimack River at Lowell, the April 2007 peak flow approached a 100-year return interval that was computed from post-flood control records and the 1936 and 1938 peak flows adjusted for flood control. In general, the magnitude of flood flow for a given return interval computed from the streamflow-gaging station period-of-record was greater than those used to calculate flood profiles in various community flood-insurance studies. In addition, the magnitude of the updated flood flow and current (2008) stage-discharge relation at a given streamflow-gaging station often produced a flood stage that was considerably different than

The 2-3 November 2015 flood of the Sió River (NE Iberian Peninsula): a flash flood that turns into a mudflow downstream

NASA Astrophysics Data System (ADS)

Carles Balasch Solanes, Josep; Lluís Ruiz-Bellet, Josep; Rodríguez, Rafael; Tuset, Jordi; Castelltort, Xavier; Barriendos, Mariano; Pino, David; Mazón, Jordi

2016-04-01

Historical and recent evidence shows that many floods in the interior of Catalonia (NE Iberian Peninsula) usually have such a great sediment load that can even alter the hydraulic behaviour of the flow. This is especially true in catchments with a great proportion of agricultural soils, which are the main source of sediment. The night of 2-3 November 2015 torrential rains fell on the headwaters of the Sió River catchment (508 km2); the subsequent flood caused four deaths and many damages along the stream. The hydrological, hydraulic and sedimentary characteristics of this recent flood have been analysed in order to gain a better insight on the characteristics of the major historical floods in the same catchment. The rainfall height on the headwaters was between 139 and 146 mm in ten hours, with a maximum intensity of about 50 mm·h-1. In the rest of the catchment it rained much less (22-71 mm). The agricultural soils in the headwaters show evidence of intense erosion by laminar and concentrated Hortonian overland flow in their superficial layer (Ap1; 10 cm), which uncovered the more compact underlying layer (Ap2). The peak flow in the headwaters (Oluges) was 90 m3·s-1 (that is, a specific peak flow near 1 m3·s-1·km-2) and it diminished downstream: 40 m3·s-1 in the centre of the catchment (Oluges + 27 km) and 15 m3·s-1 in the outlet (Oluges + 54 km). The suspended sediment load was 10-15% in volume in the headwaters and, judging from recorded images and eyewitnesses, it increased as the flow moved downstream, turning the flash flood into a mudflow. This concentration gain was most probably caused by the flood wave's water loss due to the dryness of the riverbed and translated in an increased viscosity that ultimately altered the hydraulic behaviour of the flow, slowing it down. This process of water loss has been observed in flash floods in dry riverbeds in arid and semiarid areas such as Negev (Israel) and Atacama (Chile). Historical floods in neighbouring

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas.

PubMed

Attia, Steven; Kolesar, Jill; Mahoney, Michelle R; Pitot, Henry C; Laheru, Daniel; Heun, James; Huang, Wei; Eickhoff, Jens; Erlichman, Charles; Holen, Kyle D

2008-08-01

3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) is a novel small molecule inhibitor of ribonucleotide reductase (RR) with clinical signs of activity in pancreatic cancer. Therefore, the Phase 2 Consortium (P2C) initiated a trial (two single stage studies with planned interim analysis) of 3-AP at 96 mg/m(2) intravenously days 1-4 and 15-18 of a 28-day cycle in both chemotherapy-naive and gemcitabine-refractory (GR) patients with advanced pancreatic cancer. The primary endpoint was survival at six months (chemotherapy-naive) and four months (GR). Secondary endpoints were toxicity, response, overall survival, time to progression and mechanistic studies. Fifteen patients were enrolled including one chemotherapy-naïve and 14 GR. The chemotherapy-naïve patient progressed during cycle 1 with grade 3 and 4 toxicities. Of 14 GR patients, seven received two cycles, six received one cycle and one received eight cycles. Progression precluded further treatment in 11 GR patients. Additionally, one died of an ileus in cycle 1 considered related to treatment and two stopped treatment due to toxicity. Five GR patients had grade 4 toxicities possibly related to 3-AP and six GR patients had grade 3 fatigue. Toxicities and lack of meaningful clinical benefit prompted early study closure. Four-month survival in GR patients was 21% (95% CI: 8-58%). Correlative studies confirmed that 3-AP increased the percentage of S-phase buccal mucosal cells, the presence of multidrug resistance gene polymorphisms appeared to predict leukopenia, and baseline pancreatic tumor RR M2 expression was low relative to other tumors treated with 3-AP. In conclusion, this regimen appears inactive against predominantly GR pancreatic cancer. RR M2 protein may not have a critical role in the malignant potential of pancreatic cancer.

Diadenosine polyphosphates Ap3A and Ap4A, but not Ap5A or Ap6A, induce proliferation of vascular smooth muscle cells.

PubMed

Bobbert, Peter; Schlüter, Hartmut; Schultheiss, Heinz Peter; Reusch, Hans Peter

2008-05-15

Depending on the number of phosphate groups, diadenosine polyphosphates (ApnA, Ap3A, Ap4A, Ap5A and Ap6A) differ in properties such as proliferation, apoptosis, vasoconstriction and vasodilatation of vascular smooth muscle cells (VSMCs). Possible signaling pathways leading to effects such as proliferation are still unknown. This study examined the proliferative effects of diadenosine polyphosphates on VSMCs and their intracellular pathways. Proliferation of VSMCs was measured by the cell count and [(3)H] thymidine incorporation. Phosphorylation of the MAP kinases ERK1/2 was determined by Western blotting. Single-cell [Ca(2+)](i) measurements were done to determine the influence of [Ca(2+)](i) on intracellular signaling. Stress fiber formation was assessed by fluorescence microscopy to detect an influence of G alpha(12). Ap3A and Ap4A, but not Ap5A or Ap6A, were shown to increase proliferation of VSMCs by activating P2Y receptors, which leads to stimulation of the Ras-Raf-MEK-ERK1/2 cascade. Ap3A- and Ap4A-induced activation of the MAP kinases ERK1/2 was dependent on a signaling pathway that included the EGF receptor, PKC, PLCbeta and the increase of [Ca(2+)](i). In conclusion, Ap3A and Ap4A, but not Ap5A or Ap6A, induce proliferation of VSMCs by a signaling pathway that begins with activation of P2Y receptors and leads to stimulation of the MAP kinases ERK1/2.

Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals.

PubMed Central

Pintor, J.; Díaz-Rey, M. A.; Miras-Portugal, M. T.

1993-01-01

1. Diadenosine tetraphosphate (Ap4A) a dinucleotide stored and released from rat brain synaptic terminals presents two types of affinity binding sites in synaptosomes. When [3H]-Ap4A was used for binding studies a Kd value of 0.10 +/- 0.014 nM and a Bmax value of 16.6 +/- 1.2 fmol mg-1 protein were obtained for the high affinity binding site from the Scatchard analysis. The second binding site, obtained by displacement studies, showed a Ki value of 0.57 +/- 0.09 microM. 2. Displacement of [3H]-Ap4A by non-labelled Ap4A and P2-purinoceptor ligands showed a displacement order of Ap4A > adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) > 5'-adenylyl-imidodiphosphate (AMP-PNP) > alpha,beta-methylene adenosine 5'-triphosphate (alpha,beta-MeATP) in both sites revealed by the Ki values of 0.017 nM, 0.030 nM, 0.058 nM and 0.147 nM respectively for the high affinity binding site and values of 0.57 microM, 0.87 microM, 2.20 microM and 4.28 microM respectively for the second binding site. 3. Studies of the P2-purinoceptors present in synaptosomes were also performed with [35S]-ADP-beta-S. This radioligand showed two binding sites the first with Kd and Bmax values of 0.11 +/- 0.022 nM and 3.9 +/- 2.1 fmol mg-1 of protein respectively for the high affinity binding site obtained from the Scatchard plot. The second binding site showed a Ki of 0.018 +/- 0.0035 microM obtained from displacement curves. 4. Competition studies with diadenosine polyphosphates of [35S]-ADP-beta-S binding showed a displacement order of Ap4A > Ap5A > Ap6A in the high affinity binding site and Ki values of 0.023 nM, 0.081 nM and 5.72 nM respectively.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8485620

Ecto-diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A)-hydrolase is expressed as an ectoenzyme in a variety of mammalian and human cells and adds new aspects to the turnover of Ap4A.

PubMed

von Drygalski, A; Ogilvie, A

2000-01-01

Ap4A and other dinucleotides participate in the regulation of hemostasis and blood pressure control. With the exception of two previously reported surface anchored ectoAp4A-hydrolases on bovine aortic endothelial and chromaffine cells, all Ap4A-hydrolases reported are intracellular or freely soluble. We demonstrated that ectoAp4A-hydrolases are present on a broad variety of cell types of different species: rat mesangial, bovine corneal epithelial, human Hep-G2 and peridontal cells. Ectoenzyme properties were evaluated on rat mesangium cells. Chromatography of purified plasma membranes on Sephacel 300 resulted in enrichment of ectoAp4A-hydrolase and in separation from ectoATPase. In contrast to ATPase, Ap4A-hydrolase was stable at room temperature. EctoAp4A-hydrolase also recognized ATP as substrate, and therefore is not highly specific. The molecular weight was 180 kD. Unlike ectoAMPase ectoAp4A-hydrolase was not attached via a glycosyl-phosphatidylinositol (GPI)-moiety. Concentrations of PI-PLC 10-100-fold higher than effective for ectoAMPase cleavage (10-100 mU/ml) plus extensively extended incubation times up to eight hours did not result in cleavage of ectoAp4A-hydrolase. The enzyme ectoAp4A-hydrolase might presage a direction for pharmaceutical manipulation in the control of blood pressure and hemostasis.

Crystal structures of Salmonella typhimurium propionate kinase and its complex with Ap4A: evidence for a novel Ap4A synthetic activity.

PubMed

Simanshu, Dhirendra K; Savithri, H S; Murthy, M R N

2008-03-01

Propionate kinase catalyses the last step in the anaerobic breakdown of L-threonine to propionate in which propionyl phosphate and ADP are converted to propionate and ATP. Here we report the structures of propionate kinase (TdcD) in the native form as well as in complex with diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) by X-ray crystallography. Structure of TdcD obtained after cocrystallization with ATP showed Ap4A bound to the active site pocket suggesting the presence of Ap4A synthetic activity in TdcD. Binding of Ap4A to the enzyme was confirmed by the structure determination of a TdcD-Ap4A complex obtained after cocrystallization of TdcD with commercially available Ap4A. Mass spectroscopic studies provided further evidence for the formation of Ap4A by propionate kinase in the presence of ATP. In the TdcD-Ap4A complex structure, Ap4A is present in an extended conformation with one adenosine moiety present in the nucleotide binding site and other in the proposed propionate binding site. These observations tend to support direct in-line transfer of phosphoryl group during the kinase reaction. 2007 Wiley-Liss, Inc.

78 FR 21199 - Migratory Bird Hunting; Proposed 2013-14 Migratory Game Bird Hunting Regulations (Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

... 50 CFR Part 20 Migratory Bird Hunting; Proposed 2013-14 Migratory Game Bird Hunting Regulations... Migratory Bird Hunting; Proposed 2013-14 Migratory Game Bird Hunting Regulations (Preliminary) With Requests... to establish annual hunting regulations for certain migratory game birds for the 2013-14 hunting...

78 FR 59907 - Endangered and Threatened Species: Proposed Rule To Designate Critical Habitat for the Northwest...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... for the proposed rule published on July 18, 2013 (78 FR 43005) is reopened. Comments and information on this document, identified by NOAA-NMFS-2013-0079, must be received by November 29, 2013. Requests for public hearings must be made in writing (see ADDRESSES) by November 14, 2013. ADDRESSES: You may...

77 FR 66785 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... Lafayette Parish. Approximately 1.27 +30 +29 miles upstream of Ridge Road. Coulee Ile Des Cannes--Lateral 3.... SUMMARY: On January 24, 2008, September 27, 2010, and August 3, 2011, FEMA published proposed rules in the Federal Register. The August 3, 2011 proposed rule contained an erroneous table. This notice provides...

The Black Hills-Rapid City flood of June 9-10, 1972: A description of the storm and flood

USGS Publications Warehouse

Schwarz, Francis K.; Hughes, L.A.; Hansen, E.M.; Petersen, M.S.; Kelly, Donovan B.

1975-01-01

Almost all the flood peaks occurred between 2230 MDT on June 9 and 0100 MDT on June 10, 1972, in a flood belt about 40 miles long and 20 miles wide along the eastern slopes of the Black Hills. This belt extended from Sturgis, S. Dak., on the north to Hermosa, S. Dak., on the south, with Rapid City near the center. To document the flood, peak discharge determinations were made at 49 sites. Records show that about 13,000 acre-feet of water flowed through Rapid City during the 2 days of flooding. At one point during the night of June 9, the floodwaters rose about 3.5 feet in 15 minutes. Coming off the slopes of the Black Hills, the flood peak traveled the 22 miles between Deer Creek and Rapid City in about 3.5 hours.

75 FR 55604 - Notice of Proposed Withdrawal Extension and Opportunity for Public Meeting; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMTM01000-L14300000.ET0000; MTM 79264] Notice of Proposed Withdrawal Extension and Opportunity for Public Meeting; Montana AGENCY: Bureau of... Miller, Acting Chief, Branch of Land Resources. [FR Doc. 2010-22740 Filed 9-10-10; 8:45 am] BILLING CODE...

Diadenosine polyphosphates as antagonists of the endogenous P2Y1 receptor in rat brain capillary endothelial cells of the B7 and B10 clones

PubMed Central

Vigne, Paul; Breittmayer, Jean Philippe; Frelin, Christian

2000-01-01

Diadenosine polyphosphates (ApnAs, n=2–7) are considered as stress mediators in the cardiovascular system. They act both via identified P2 purinoceptors and via yet to be characterized receptors. This study analyses the actions of ApnAs in clones of rat brain capillary endothelial cells that express P2Y1 receptors (B10 cells) or both P2Y1 and P2Y2 receptors (B7 cells).B10 cells responded to Ap3A with rises in intracellular Ca2+ concentration ([Ca2+]i). This response was prevented by adenosine-3′-phosphate-5′-phosphate, an antagonist of P2Y1 receptors. It was largely suppressed by a treatment with apyrase VII or with creatine phosphokinase/creatine phosphate to degrade contaminating ADP.ApnAs inhibited ADP induced increases in [Ca2+]i mediated by P2Y1 receptors by shifting ADP concentration-response curves to larger concentrations. Apparent Ki values were estimated to be 6 μM for Ap4A, 10 μM for Ap5A and 47 μM for Ap6A. Ap2A and Ap3A were much less active.ApnAs were neither agonists nor antagonists of the endogenous P2Y2 receptor in B7 cells.ApnAs are neither agonists nor antagonists of the Gi-coupled, ADP receptor in B10 cells.The results suggest that most actions of ApnAs in B7 and B10 cells can be accounted for by endogenous P2Y1 receptors. Ap4A, Ap5A and Ap6A are specific antagonists of endogenous Ca2+-coupled P2Y1 receptors. PMID:10742308

Historical flood data series of Eastern Spanish Coast (14th-20th centuries). Improving identification of climatic patterns and human factors of flood events from primary documentary sources

NASA Astrophysics Data System (ADS)

Alberola, Armando; Barriendos, Mariano; Gil-Guirado, Salvador; Pérez-Morales, Alfredo; Balasch, Carles; Castelltort, Xavier; Mazón, Jordi; Pino, David; Lluís Ruiz-Bellet, Josep; Tuset, Jordi

2016-04-01

major flood events on Eastern coast of Iberian Peninsula, with identification and evaluation of natural and human factors involved on that. References: Alberola, A. 2006. "Entre la sequía y la inundación. Una aproximación a las avenidas históricas de los ríos valencianos durante el siglo XVIII", in Gérard Chastagnaret and Antonio Gil Olcina (eds.), Riesgo de inundaciones en el Mediterráneo occidental, Casa de Velázquez-Universidad de Alicante, p. 1-30. ISBN 84-95555-89-1. Barriendos, M., Ruiz-Bellet, J.L., Tuset, J., Mazón, J., Balasch, C., Pino, D., Ayala, J.L.: 2014, "The 'Prediflood' database of historical floods in Catalonia (NE Iberian Peninsula) AD 1035-2013, and its potential applications in flood analysis", Hydrology and Earth System Sciences, 18: 1-17. DOI: 10.5194/hess-18-1-2014. Gil-Guirado, S.: 2013. Reconstrucción climática histórica y análisis evolutivo de la vulnerabilidad y adaptación a las sequías e inundaciones en la Cuenca del Segura (España) y en la Cuenca del Río Mendoza (Argentina). Doctoral dissertation. Universidad de Murcia, Murcia, España.

75 FR 14091 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... CFR part 10, Environmental Consideration. An environmental impact assessment has not been prepared... No.: FEMA-B-1038 Cottonwood Creek Approximately 2,000 feet + 1313 Unincorporated Areas of upstream of... Homeland Security, Federal Emergency Management Agency. [FR Doc. 2010-6421 Filed 3-23-10; 8:45 am] BILLING...

Structural characterization of the N-terminal mineral modification domains from the molluscan crystal-modulating biomineralization proteins, AP7 and AP24.

PubMed

Wustman, Brandon A; Morse, Daniel E; Evans, John Spencer

2004-08-05

The AP7 and AP24 proteins represent a class of mineral-interaction polypeptides that are found in the aragonite-containing nacre layer of mollusk shell (H. rufescens). These proteins have been shown to preferentially interfere with calcium carbonate mineral growth in vitro. It is believed that both proteins play an important role in aragonite polymorph selection in the mollusk shell. Previously, we demonstrated the 1-30 amino acid (AA) N-terminal sequences of AP7 and AP24 represent mineral interaction/modification domains in both proteins, as evidenced by their ability to frustrate calcium carbonate crystal growth at step edge regions. In this present report, using free N-terminal, C(alpha)-amide "capped" synthetic polypeptides representing the 1-30 AA regions of AP7 (AP7-1 polypeptide) and AP24 (AP24-1 polypeptide) and NMR spectroscopy, we confirm that both N-terminal sequences possess putative Ca (II) interaction polyanionic sequence regions (2 x -DD- in AP7-1, -DDDED- in AP24-1) that are random coil-like in structure. However, with regard to the remaining sequences regions, each polypeptide features unique structural differences. AP7-1 possesses an extended beta-strand or polyproline type II-like structure within the A11-M10, S12-V13, and S28-I27 sequence regions, with the remaining sequence regions adopting a random-coil-like structure, a trait common to other polyelectrolyte mineral-associated polypeptide sequences. Conversely, AP24-1 possesses random coil-like structure within A1-S9 and Q14-N16 sequence regions, and evidence for turn-like, bend, or loop conformation within the G10-N13, Q17-N24, and M29-F30 sequence regions, similar to the structures identified within the putative elastomeric proteins Lustrin A and sea urchin spicule matrix proteins. The similarities and differences in AP7 and AP24 N-terminal domain structure are discussed with regard to joint AP7-AP24 protein modification of calcium carbonate growth. Copyright 2004 Wiley Periodicals, Inc.

Cardioprotective effect of diadenosine tetraphosphate (AP4A) cardioplegia in isolated rat hearts.

PubMed

Ahmet, I; Sawa, Y; Nishimura, M; Matsuda, H

2000-01-01

Preischemic administration of diadenosine tetraphosphate (AP4A) has been shown to be cardioprotective. We evaluated the protective effect of AP4A when used as a cardioplegic adjuvant and tested contributions of the ATP-sensitive potassium channel (K ATP channel), adenosine receptor (AR), and purine 2y receptor (P2yR) to the effect of AP4A. Isolated buffer-perfused rat hearts were subjected to 23 min of ischemia (37 degrees C) followed by 20 min of reperfusion. Cardioplegia solution (St. Thomas Hospital solution) was infused during the first 3 min of ischemia. AP4A (10 microM) or AP4A with glibenclamide (K ATP channel blocker, 100 microM), 8-SPT (AR antagonist, 300 microM) or reactive blue (P2yR antagonist, 13 nM) were added to the cardioplegia solution. Compared with the cardioplegia solution alone, administration of AP4A with the solution significantly increased the recovery of rate-pressure production (75% +/- 11% vs 58% +/- 10%; P < 0.05) and dp/dt at the end of reperfusion, and reduced the leakage of creatine kinase (3.2 +/- 3.7 vs 13.2 +/- 10.1 IU/g; P < 0.05) during reperfusion. This effect was reversed by coadministration of glibenclamide or reactive blue but not 8-SPT. The addition of AP4A into the cardioplegia solution led to an added cardioprotective effect, either by opening the K ATP channel or by activating P2yR.

Seismic Monitoring and Characterization of the 2012 Outburst Flood of the Ice-Dammed Lake A.P.Olsen (NE Greenland)

NASA Astrophysics Data System (ADS)

Behm, M.; Walter, J. I.; Binder, D.; Mertl, S.

2017-12-01

Since the Zackenberg Research Station (ZRS) in NE-Greenland was established in 1995, regular floods of the adjacent Zackenberg River have been observed. The floods result from the sudden discharge of a marginal, ice-dammed lake at the pre-dominantly cold-based A.P. Olsen Ice Cap about 35 km inland. The lake filling usually starts with the melting season in May/June and ends with the flood sometime after early July. The run-off water from the lake discharges through the subsurface of the adjacent Argo glacier. The actual migration paths and depth of the water within the glacier are unknown until it re-appears at the glacier terminus at a distance of 4 km to the ice-dam. In spring 2012 a surface seismic monitoring network was installed on Argo glacier in 2-3 m boreholes near the lake to acquire continuous data for the whole fill- and drain cycle from start of May to end of November. The network comprises 3 stations with three-component sensors and 2 stations designed as tripartite arrays with vertically oriented sensors. The maximum interstation distance is 1.2 km. Microseismic event detection and localization is facilitated by the homogenous seismic structure of the ice and the extremely high S/N ratio of the borehole installations. An initial detection based on an STA/LTA algorithm and event assocator results in order-of-magnitude 100,000 seismic events. These events are generally attributed to the opening of surface crevasses due to the presence of weak body waves and strong surface wave energy, interpreted to be Rayleigh waves with dominant frequencies around 1-4 Hz. Time-lapse cross-correlations of the ambient seismic noise field reconstruct the surface waves travelling between the stations. Weekly stacks of the cross-correlations are stable, and show a distinct change correlated with the outburst flood. Apparent surface wave velocities increase slightly several weeks prior to the outburst event, which itself is characterized by a decrease in the correlation

Proposal for a quantitative index of flood disasters.

PubMed

Feng, Lihua; Luo, Gaoyuan

2010-07-01

Drawing on calculations of wind scale and earthquake magnitude, this paper develops a new quantitative method for measuring flood magnitude and disaster intensity. Flood magnitude is the quantitative index that describes the scale of a flood; the flood's disaster intensity is the quantitative index describing the losses caused. Both indices have numerous theoretical and practical advantages with definable concepts and simple applications, which lend them key practical significance.

75 FR 22699 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... from the requirements of 44 CFR part 10, Environmental Consideration. An environmental impact..., Nebraska, and Incorporated Areas Docket No.: FEMA-B-7759 Hell Creek Approximately 100 feet +1038 City of La... of Homeland Security, Federal Emergency Management Agency. [FR Doc. 2010-10053 Filed 4-29-10; 8:45 am...

A proposed STAR microvertex detector using Active Pixel Sensors with some relevant studies on APS performance

NASA Astrophysics Data System (ADS)

Kleinfelder, S.; Li, S.; Bieser, F.; Gareus, R.; Greiner, L.; King, J.; Levesque, J.; Matis, H. S.; Oldenburg, M.; Ritter, H. G.; Retiere, F.; Rose, A.; Schweda, K.; Shabetai, A.; Sichtermann, E.; Thomas, J. H.; Wieman, H. H.; Bichsel, H.

2006-09-01

A vertex detector that can measure particles with charm or bottom quarks would dramatically expand the physics capability of the STAR detector at RHIC. To accomplish this, we are proposing to build the Heavy Flavor Tracker (HFT) using 2×2 cm Active Pixels Sensors (APS). Ten of these APS chips will be arranged on a ladder (0.28% of a radiation length) at radii of 1.5 and at 5.0 cm. We have examined several properties of APS chips, so that we can characterize the performance of this detector. Using 1.5 GeV/ c electrons, we have measured the charge collected and compared it to the expected charge. To achieve high efficiency, we have considered two different cluster finding algorithms and found that the choice of algorithm is dependent on noise level. We have demonstrated that a Scanning Electron Microscope can probe properties of an APS chip. In particular, we studied several position resolution algorithms. Finally, we studied the properties of pixel pitches from 5 to 30 μm.

7 CFR 3406.14 - Proposal review-teaching.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal review-teaching. 3406.14 Section 3406.14... Review and Evaluation of a Teaching Proposal § 3406.14 Proposal review—teaching. The proposal evaluation process includes both internal staff review and merit evaluation by peer review panels comprised of...

10 CFR 501.14 - Notice to Environmental Protection Agency.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Notice to Environmental Protection Agency. 501.14 Section 501.14 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 501.14 Notice to Environmental Protection Agency. A copy of any proposed rule or...

44 CFR 65.16 - Standard Flood Hazard Determination Form and Instructions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... by the Director as an area having special flood hazards and in which flood insurance under this title.... Finally, the form is available through the Internet at http://www.fema.gov/nfip/mpurfi.htm. [63 FR 27857...

78 FR 36098 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

... of 1978, 3 CFR, 1978 Comp., p. 329; E.O. 12127, 44 FR 19367, 3 CFR, 1979 Comp., p. 376. Sec. 67.11... Areas Docket No.: FEMA-B-1216 Mississippi River Approximately 1.67 miles +38 City of Plaquemine, Town upstream of the White of White Castle. Castle-Carville Ferry. Approximately 2 miles +38 upstream of the...

76 FR 12983 - Notice of Proposed Information Collection: Comment Request; Tenant Resource Network Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5484-N-06] Notice of Proposed Information Collection: Comment Request; Tenant Resource Network Program AGENCY: Office of the Assistant...: Tenant Resource Network Program. OMB Control Number, if applicable: 2502-new-65pTRNP. Description of the...

Surfactant-enhanced alkaline flooding: Buffering at intermediate alkaline pH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rudin, J.; Wasan, D.T.

1993-11-01

The alkaline flooding process involves injecting alkaline agents into the reservoir to produce more oil than is produced through conventional waterflooding. The interaction of the alkali in the flood water with the naturally occurring acids in the reservoir oil results in in-situ formation of soaps, which are partially responsible for lowering IFT and improving oil recovery. The extent to which IFT is lowered depends on the specific oil and injection water properties. Numerous investigators have attempted to clarify the relationship between system chemical composition and IFT. An experimental investigation of buffered alkaline flooding system chemistry was undertaken to determine themore » influence of various species present on interfacial tension (IFT) as a function of pH and ionic strength. IFT was found to go through an ultralow minimum in certain pH ranges. This synergism results from simultaneous adsorption of un-ionized and ionized acid species on the interface.« less

Evidence for a G protein-coupled diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) receptor binding site in lung membranes from rat.

PubMed

Laubinger, W; Reiser, G

1999-01-29

Nucleotide receptors are of considerable importance in the treatment of lung diseases, such as cystic fibrosis. Because diadenosine polyphosphates may also be of significance as signalling molecules in lung, as they are in a variety of tissues, in the present work we investigated the binding sites for [3H]diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) in plasma membranes from rat lung and studied their possible coupling to G proteins. We present evidence for a single high-affinity binding site for [3H]Ap4A with similar affinity for other diadenosine polyphosphates ApnA (n = 2 to 6). Displacement studies with different nucleotides revealed that the [3H]Ap4A binding site was different from P2X and P2Y2 receptor binding sites. Pretreatment of lung membranes with GTPgammaS or GTP in the presence of Mg2+ increased the Ki for Ap4A from 91 nM to 5.1 microM, which is indicative of G protein coupling. The putative coupling to G proteins was further confirmed by the enhancement of [35S]GTPgammaS binding (to Galpha proteins) to lung membranes by Ap4A (63% increase over basal) in a concentration-dependent manner. Therefore, our data for the first time provide evidence of a G protein-coupled Ap4A binding site in lung membranes.

76 FR 19007 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Birch Creek Road. Black Mingo Creek At the upstream side of None +14 Unincorporated Areas of County Line... Road. Boggy Swamp A At the Black Mingo None +25 Unincorporated Areas of Creek confluence. Williamsburg... mile None +35 Unincorporated Areas of upstream of the Black Williamsburg County. River confluence...

Precipitation thresholds for triggering floods in Corgo hydrographic basin (Northern Portugal)

NASA Astrophysics Data System (ADS)

Santos, Monica; Fragoso, Marcelo

2016-04-01

The precipitation is a major cause of natural hazards and is therefore related to the flood events (Borga et al., 2011; Gaál et al., 2014; Wilhelmi & Morss, 2013). The severity of a precipitation event and their potential damage is dependent on the total amount of rain but also on the intensity and duration event (Gaál et al., 2014). In this work, it was established thresholds based on critical combinations: amount / duration of flood events with daily rainfall data for Corgo hydrographic basin, in northern Portugal. In Corgo basin are recorded 31 floods events between 1865 and 2011 (Santos et al., 2015; Zêzere et al., 2014). We determined the minimum, maximum and pre-warning thresholds that define the boundaries so that an event may occur. Additionally, we applied these thresholds to different flood events occurred in the past in the study basin. The results show that the ratio between the flood events and precipitation events that occur above the minimum threshold has relatively low probability of a flood happen. These results may be related to the reduced number of floods events (only those that caused damage reported by the media and produced some type of damage). The maximum threshold is not useful for floods forecasting, since the majority of true positives are below this limit. The retrospective analysis of the thresholds defined suggests that the minimum and pre warning thresholds are well adjusted. The application of rainfall thresholds contribute to minimize possible situations of pre-crisis or immediate crisis, reducing the consequences and the resources involved in emergency response of flood events. References Borga, M., Anagnostou, E. N., Blöschl, G., & Creutin, J. D. (2011). Flash flood forecasting, warning and risk management: the HYDRATE project. Environmental Science & Policy, 14(7), 834-844. doi: 10.1016/j.envsci.2011.05.017 Gaál, L., Molnar, P., & Szolgay, J. (2014). Selection of intense rainfall events based on intensity thresholds and

Base (100-year) flood elevations for selected sites in Livingston County, Missouri

USGS Publications Warehouse

Southard, Rodney E.; Richards, Joseph M.

2002-01-01

The primary criteria for community participation in the National Flood Insurance Program is the adoption and enforcement of floodplain management requirements that minimize the potential for flood damages to existing and proposed development in flood-hazard areas. This report provides base flood elevations (BFE) for a 100-year recurrence-interval flood for use in the management and regulation of 18 flood-hazard areas designated by the Federal Emergency Management Agency as approximate Zone A areas in Livingston County, Missouri. The one-dimensional surface-water flow models HEC-RAS and Water-Surface PROfile (WSPRO) were used to compute base (100-year) flood elevations for 18 Zone A sites. The HEC-RAS model was used at BFE sites 1 to 6, 9, 10, and 15 to 18. The WSPRO model was used at BFE sites 7, 8, and 11 to 14. The 18 sites are all located in Livingston County, Missouri, at U.S., State, or County road crossings, and the base flood elevation was determined at the upstream side of each crossing. The base (100-year) flood elevations for BFE 1, 2, and 3 on Shoal Creek at Dawn and Shoal Creek Drainage Ditch near Dawn are 701.0, 701.0, and 696.5 feet, respectively. The base (100-year) flood elevations for BFE 4 and 5 on Indian Branch near Sampsel and a tributary to Indian Branch near Sampsel are 711.7 and 755.4 feet, respectively. Site BFE 6 is located on Honey Creek near Farmersville and the base (100-year) flood elevation for this site is 730.8 feet. One site (BFE 7) is located on No Creek near Farmersville. The base (100-year) flood elevation for this site is 731.3 feet. Site BFE 8 is located on Crooked Creek near Chillicothe and the base (100-year) elevation is 716.4 feet. One site (BFE 9) is located on a tributary to Coon Creek at Chillicothe. The base (100-year) flood elevation for this site is 734.9 feet. Two sites (BFE 10 and 11) are located on Blackwell Branch at Chillicothe. The base (100-year) flood elevation for BFE 10 is 738.9 feet and for BFE 11 is 701

10 CFR 501.14 - Notice to Environmental Protection Agency.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Notice to Environmental Protection Agency. 501.14 Section 501.14 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 501.14 Notice to Environmental Protection Agency. A copy of any proposed rule or order that imposes a prohibition, order that...

75 FR 19415 - Agency Information Collection Activities: Proposed Collection; Comment Request, 1660-0022...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... implement practices, such as building codes and public education activities, that are considered to reduce..., Department of Homeland Security. [FR Doc. 2010-8496 Filed 4-13-10; 8:45 am] BILLING CODE 9110-11-P ...

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

PubMed Central

Attia, Steven; Kolesar, Jill; Mahoney, Michelle R.; Pitot, Henry C.; Laheru, Daniel; Heun, James; Huang, Wei; Eickhoff, Jens; Erlichman, Charles

2015-01-01

Summary 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) is a novel small molecule inhibitor of ribonucleotide reductase (RR) with clinical signs of activity in pancreatic cancer. Therefore, the Phase 2 Consortium (P2C) initiated a trial (two single stage studies with planned interim analysis) of 3-AP at 96 mg/m2 intravenously days 1–4 and 15–18 of a 28-day cycle in both chemotherapy-naive and gemcitabine-refractory (GR) patients with advanced pancreatic cancer. The primary endpoint was survival at six months (chemotherapy-naive) and four months (GR). Secondary endpoints were toxicity, response, overall survival, time to progression and mechanistic studies. Fifteen patients were enrolled including one chemotherapy-naïve and 14 GR. The chemotherapy-naïve patient progressed during cycle 1 with grade 3 and 4 toxicities. Of 14 GR patients, seven received two cycles, six received one cycle and one received eight cycles. Progression precluded further treatment in 11 GR patients. Additionally, one died of an ileus in cycle 1 considered related to treatment and two stopped treatment due to toxicity. Five GR patients had grade 4 toxicities possibly related to 3-AP and six GR patients had grade 3 fatigue. Toxicities and lack of meaningful clinical benefit prompted early study closure. Four-month survival in GR patients was 21% (95% CI: 8–58%). Correlative studies confirmed that 3-AP increased the percentage of S-phase buccal mucosal cells, the presence of multidrug resistance gene polymorphisms appeared to predict leukopenia, and baseline pancreatic tumor RR M2 expression was low relative to other tumors treated with 3-AP. In conclusion, this regimen appears inactive against predominantly GR pancreatic cancer. RR M2 protein may not have a critical role in the malignant potential of pancreatic cancer. PMID:18278438

76 FR 30326 - Proposed Subsequent Arrangement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... International Security, National Nuclear Security Administration, Department of Energy. ACTION: Proposed... United States of America and the Government of Japan Concerning Peaceful Uses of Nuclear Energy. DATES... Energy. Anne M. Harrington, Deputy Administrator, Defense Nuclear Nonproliferation. [FR Doc. 2011-12919...

75 FR 42726 - Proposed Agency Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... the agency's estimate of the burden of the proposed collection of information, including the validity... July 19, 2010. Terri T. Lee, Chief Operating Officer, Electricity Delivery and Energy Reliability. [FR...

A method of semi-quantifying β-AP in brain PET-CT 11C-PiB images.

PubMed

Jiang, Jiehui; Lin, Xiaoman; Wen, Junlin; Huang, Zhemin; Yan, Zhuangzhi

2014-01-01

Alzheimer's disease (AD) is a common health problem for elderly populations. Positron emission tomography-computed tomography (PET-CT)11C-PiB for beta-P (amyloid-β peptide, β-AP) imaging is an advanced method to diagnose AD in early stage. However, in practice radiologists lack a standardized value to semi-quantify β-AP. This paper proposes such a standardized value: SVβ-AP. This standardized value measures the mean ratio between the dimension of β-AP areas in PET and CT images. A computer aided diagnosis approach is also proposed to achieve SVβ-AP. A simulation experiment was carried out to pre-test the technical feasibility of the CAD approach and SVβ-AP. The experiment results showed that it is technically feasible.

76 FR 70745 - Agency Information Collection Activities: Proposed Collection; Comment Request; National Flood...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2011-0034...; National Flood Insurance Program--Mortgage Portfolio Protection Program AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency Management Agency, as part of its...

76 FR 64361 - Agency Information Collection Activities: Proposed Collection; Comment Request; National Flood...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-18

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2011-0029...; National Flood Insurance Program Claims Appeals Process AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: The Federal Emergency Management Agency, as part of its continuing effort to...

7 CFR 3405.14 - Proposal review.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal review. 3405.14 Section 3405.14 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Proposal Review and...

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding Protein

NASA Astrophysics Data System (ADS)

Hotamisligil, Gokhan S.; Johnson, Randall S.; Distel, Robert J.; Ellis, Ramsey; Papaioannou, Virginia E.; Spiegelman, Bruce M.

1996-11-01

Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to fatty acids such as oleic and retinoic acid. Mice with a null mutation in aP2, the gene encoding the adipocyte FABP, were developmentally and metabolically normal. The aP2-deficient mice developed dietary obesity but, unlike control mice, they did not develop insulin resistance or diabetes. Also unlike their obese wild-type counterparts, obese aP2-/- animals failed to express in adipose tissue tumor necrosis factor-α (TNF-α), a molecule implicated in obesity-related insulin resistance. These results indicate that aP2 is central to the pathway that links obesity to insulin resistance, possibly by linking fatty acid metabolism to expression of TNF-α.

CitAP2.10 activation of the terpene synthase CsTPS1 is associated with the synthesis of (+)-valencene in ‘Newhall’ orange

PubMed Central

Shen, Shu-ling; Yin, Xue-ren; Zhang, Bo; Xie, Xiu-lan; Jiang, Qian; Grierson, Donald; Chen, Kun-song

2016-01-01

Aroma is a vital characteristic that determines the quality and commercial value of citrus fruits, and characteristic volatiles have been analyzed in different citrus species. In sweet orange, Citrus sinensis, the sesquiterpene (+)-valencene is a key volatile compound in the fruit peel. Valencene synthesis is catalyzed by the terpene synthase CsTPS1, but the transcriptional mechanisms controlling its gene expression are unknown. Here, the AP2/ERF (APETALA2/ethylene response factor) transcription factor, CitAP2.10, is characterized as a regulator of (+)-valencene synthesis. The expression pattern of CitAP2.10 was positively correlated with (+)-valencene content and CsTPS1 expression. Dual-luciferase assays indicated that CitAP2.10 could trans-activate the CsTPS1 promoter. Ethylene enhanced expression of CitAP2.10 and this effect was abolished by the ethylene antagonist 1-methylcyclopropene. The role and function of CitAP2.10 in (+)-valencene biosynthesis were confirmed using the Arabidopsis homolog (AtWRI1), which also transiently activated the CsTPS1 promoter. Furthermore, transient over-expression of CitAP2.10 triggered (+)-valencene biosynthesis in sweet orange fruit. These results indicate that CitAP2.10 regulates (+)-valencene synthesis via induction of CsTPS1 mRNA accumulation. PMID:27194737

Permeability of ferret trachea in vitro to {sup 99m}{Tc}-DTPA and [{sup 14}C]antipyrine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanafi, Z.; Webber, S.E.; Widdicombe, J.G.

1994-09-01

Platelet-activating factor (PAF) and vasoactive drugs were tested on permeability of ferret trachea in vitro by measuring fluxes of {sup 99m}{Tc}-diethylenetriamine pentaacetic acid ({sup 99m}{Tc}-DTPA; hydrophilic) and [{sup 14}C]antipyrine ([{sup 14}C]AP; lipophilic) across the tracheal wall. Tracheae were bathed on both sides with Krebs-Henseleit buffer, with luminal buffer containing either {sup 99m}{Tc}-DTPA or [{sup 14}C]AP. Luminal and abluminal radioactivities, potential difference, and tracheal smooth muscle tone were measured. Baseline {sup 99m}{Tc}-DTPA and [{sup 14}C]AP permeability coefficients were - 4.7 {+-} 0.6 (SE) x 10{sup {minus}7} and -2.2 {+-} 0.1 x 10{sup {minus}5} cm/s, respectively. PAF (10 {mu}M) increased permeability tomore » {sup 99m}{Tc}-DTPA to -35.3 {+-} 7.6 x 10{sup {minus}7} cm/s (P < 0.05), but permeability to [{sup 14}C]AP did not change, suggesting that paracellular but not transcellular transport was affected. Abluminal and luminal applications of methacholine (MCh, 20 {mu}M), phenylephrine (PE, 100 {mu}M), and albuterol (Alb, 100 {mu}M) caused no change in permeability to {sup 99m}{Tc}-DTPA before or after exposure to luminal PAF, but abluminal histamine (Hist, 10 {mu}M) significantly increased permeability. Abluminal Hist decreased permeability to [{sup 14}C]AP before and after exposure to PAF. MCh, PE, and Hist increased smooth muscle tone; Alb and PAF had no effect. Thus, only PAF and Hist altered permeability to {sup 99m}{Tc}-DTPA, and MCh, PE, and Hist changed smooth muscle tone. Tracheal permeability changes were greater for the hydrophilic than for the lipophilic agent. 37 refs., 11 figs., 1 tab.« less

77 FR 31814 - National Flood Insurance Program (NFIP); Insurance Coverage and Rates

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

... structures (target repetitive loss buildings) insured under the NFIP. The Notice of Proposed Rulemaking (NPRM) defined target repetitive loss buildings as those with four or more losses, or with two or more flood... flood insurance coverage to a target repetitive loss building, if an owner declined an offer of...

The duality of LysU, a catalyst for both Ap4A and Ap3A formation.

PubMed

Wright, Michael; Boonyalai, Nonlawat; Tanner, Julian A; Hindley, Alison D; Miller, Andrew D

2006-08-01

Heat shock inducible lysyl-tRNA synthetase of Escherichia coli (LysU) is known to be a highly efficient diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) synthase. However, we use an ion-exchange HPLC technique to demonstrate that active LysU mixtures actually have a dual catalytic activity, initially producing Ap4A from ATP, before converting that tetraphosphate to a triphosphate. LysU appears to be an effective diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) synthase. Mechanistic investigations reveal that Ap3A formation requires: (a) that the second step of Ap4A formation is slightly reversible, thereby leading to a modest reappearance of adenylate intermediate; and (b) that phosphate is present to trap the intermediate (either as inorganic phosphate, as added ADP, or as ADP generated in situ from inorganic phosphate). Ap3A forms readily from Ap4A in the presence of such phosphate-based adenylate traps (via a 'reverse-trap' mechanism). LysU is also clearly demonstrated to exist in a phosphorylated state that is more physically robust as a catalyst of Ap4A formation than the nonphosphorylated state. However, phosphorylated LysU shows only marginally improved catalytic efficiency. We note that Ap3A effects have barely been studied in prokaryotic organisms. By contrast, there is a body of literature that describes Ap3A and Ap4A having substantially different functions in eukaryotic cells. Our data suggest that Ap3A and Ap4A biosynthesis could be linked together through a single prokaryotic dual 'synthase' enzyme. Therefore, in our view there is a need for new research into the effects and impact of Ap3A alone and the intracellular [Ap3A]/[Ap4A] ratio on prokaryotic organisms.

Effect of diadenosine tetraphosphate (AP4A) on coronary arterial microvessels in the beating canine heart.

PubMed

Sugimura, A; Kanatsuka, H; Tanikawa, T; Ong, B H; Shirato, K

2000-11-01

Diadenosine tetraphosphate (AP4A) can be released from activated platelets and the present study examined its effect on coronary arterial microvessels. The role of purinoceptors in the coronary microcirculation in vivo was also investigated. In open chest dogs, coronary arterioles were observed using a microscope with a floating objective. In Protocol 1, AP4A (1, 10, 100 and 1,000 micromol/L) was superfused onto the heart surface before and during the superfusion of 10 micromol/L of 8-phenyltheophylline (8-PT), a P1 purinoceptor blocker. In Protocol 2, AP4A (0.1, 1, 10, and 100 nmol x kg(-1) x min(-1)) was infused into the left anterior descending coronary artery before and during the superfusion of 10 micromol/L of 8-PT. In addition to 8-PT, 30 micromol/L of pyridoxalphosphate-6-azophenyl 2',4'-disulphonic acid (PPADS), a P2X purinoceptor blocker in Protocol 3, or 300 micromol/L of N(omega)-nitro-L-arginine (LNNA) in Protocol 4, was continuously superfused, and 4 doses of AP4A were cumulatively superfused as in Protocol 1. In Protocol 5, 10 micromol/L of alpha,beta-methylene ATP, an agonist of P2X purinoceptors, was superfused for 60 min. Superfused AP4A dilated arterioles in a dose-dependent manner. The magnitude of dilatation was greater in smaller arterioles (small vessel < or = 150 microm: 24.5+/-2.2% vs large vessel > 150 microm: 10.6+/-1.5% at a dose of 1,000 micromol/L, p<0.001). On the other hand, intraluminally applied AP4A also dilated arterioles, but no size dependency was shown. In the presence of 8-PT, vasodilatory responses to superfused and intraluminally applied AP4A were attenuated and the lower doses of AP4A constricted arterioles. This vasoconstrictor effect was not affected by PPADS. The vasodilatory effect of the higher doses of AP4A was almost abolished in the presence of LNNA. Alpha,beta-methylene ATP had no effect on coronary microvascular diameters. AP4A has bidirectional effects on coronary arterial microvessels: vasodilatory effects

Baseline water quality of Long Meadow Lake, Ponds AP-9 and AP-10, and Black Dog Creek, Hennepin and Dakota counties, Minnesota

USGS Publications Warehouse

Payne, G.A.

1977-01-01

Long Meadow Lake, Black Dog Creek, and Ponds AP-9 and AP-10 which lie in an area designated for a trunk highway bridge crossing the Minnesota River, were sampled for baseline water quality prior to construction of the bridge. Data collected show that dissolved solids fluctuate seasonally. Dissolved oxygen:/ranged from less than 1 milligram per liter under an ice cover to 13-9 milligrams per liter in the September sample at site 4 in Long Meadow Lake. The phytoplankton analyses showed pulses in algae populations, blue-green algae being the dominant type in at least one sample from each of the water courses.

76 FR 26976 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

..., identified by Docket No. FEMA-B-1193, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal... Order 12988, Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order...

75 FR 78647 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

..., identified by Docket No. FEMA-B-1163, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal.... Executive Order 12988, Civil Justice Reform. This proposed rule meets the applicable standards of Executive...

76 FR 3590 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

..., identified by Docket No. FEMA-B-1171, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

76 FR 59960 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

..., identified by Docket No. FEMA-B-1220, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. [[Page...

76 FR 19018 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

..., identified by Docket No. FEMA-B-1179, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

76 FR 19005 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

..., identified by Docket No. FEMA-B-1187, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

76 FR 66887 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

..., identified by Docket No. FEMA-B-1226, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. [[Page...

76 FR 40738 - Agency Information Collection Activities: Proposed Collection; Comment Request; Standard Flood...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... Community Development and Regulatory Improvement Act of 1994 was signed into law. Section 303 (a) of this... requirement for federally regulated lending institutions to determine whether a building or mobile home... Regulatory Improvement Act of 1994. The establishment of the Standard Flood Hazard Determination form has...

75 FR 78664 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... submit comments, identified by Docket No. FEMA-B-1169, to Luis Rodriguez, Chief, Engineering Management... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

77 FR 22551 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

... Tributary 5, Puyallup River (overflow through golf course between State Route 162 and Puyallup River... Waterway via numerous flow paths), Puyallup River (with consideration of levees), Puyallup River (without..., State, or regional entities. These proposed elevations are used to meet the floodplain management...

Pakistan Flooding

Atmospheric Science Data Center

2013-04-16

article title:  Flooding in Pakistan     View Larger Image In late July 2010, flooding caused by heavy monsoon rains began in several regions of Pakistan, ... river is 23 kilometers (14 miles) wide or more in spots, and flooding in much of the surrounding region, particularly in the Larkana ...

Floods of February 1989 in Tennessee

USGS Publications Warehouse

Quinones, Ferdinand; Gamble, C.R.

1990-01-01

Rainfall amounts of over 5 inches the night of February 13 and the morning of February 14, 1989, caused flooding in areas of Middle and West Tennessee. The towns of Lebanon in Middle Tennessee and Obion in West Tennessee were most severely affected. Most of the business district in Lebanon and many residential areas in Obion were flooded. Recurrence intervals for 24-hour rainfall totals were as high as 25 years at some sites but most peak discharges had recurrence intervals of less than 10 years. Rainfall amounts for the period February 13-20, 1989, peak stages and discharges for this flood, the peak of record, and a list of discharge measurements made during the flood are documented. (USGS)

Combining empirical approaches and error modelling to enhance predictive uncertainty estimation in extrapolation for operational flood forecasting. Tests on flood events on the Loire basin, France.

NASA Astrophysics Data System (ADS)

Berthet, Lionel; Marty, Renaud; Bourgin, François; Viatgé, Julie; Piotte, Olivier; Perrin, Charles

2017-04-01

France (major spring floods in June 2016 on the Loire river tributaries and flash floods in fall 2016) will be shown and discussed. References Bourgin, F. (2014). How to assess the predictive uncertainty in hydrological modelling? An exploratory work on a large sample of watersheds, AgroParisTech Wang, Q. J., Shrestha, D. L., Robertson, D. E. and Pokhrel, P (2012). A log-sinh transformation for data normalization and variance stabilization. Water Resources Research, , W05514, doi:10.1029/2011WR010973

Exercise Intensity and Technical Demands of Small-Sided Soccer Games for Under-12 and Under-14 Players: Effect of Area per Player.

PubMed

Martone, Domenico; Giacobbe, Moreno; Capobianco, Adriano; Imperlini, Esther; Mancini, Annamaria; Capasso, Mario; Buono, Pasqualina; Orrù, Stefania

2017-06-01

The aim of this study was to evaluate the effects of 6 different areas per player (AP) on exercise intensity (EI) measured during small-sided games (SSGs) and expressed as percentage of maximal heart rate (%MHR) and technical actions (TAs) involvement with the ball, crosses, headers, tackles, shots on goal, dribbling, passing, and target passing-in U-12 and U-14 soccer players during SSGs. Seventeen male U-12 soccer players (age 10.0 ± 0.5 years, body mass 39.3 ± 5.3 kg, and height 143.8 ± 4.6 cm) and 16 male U-14 soccer players (age 13.2 ± 0.3 years, body mass 46.6 ± 11.9 kg, and height 154.8 ± 8.5 cm) performed SSGs with different AP: 40, 50, 66.7, 90, 112.5, and 150 m. Our results indicate that at larger AP, the U-12 group's mean EI values were significantly higher than those at smaller AP (p ≤ 0.05); in addition, intergroup comparison showed that EI was higher in U-12 than that in U-14 players when AP of 112.5 and 150 m were considered (p ≤ 0.05). Technical action analysis evidenced that moving from smaller to larger AP, U-14 players adapted better to AP changes. In conclusion, these results suggest that AP influences differently EI and TAs in U-12 and U-14 players. Our results could be taken into account by conditioning coaches to better tailor the physiological and technical training in young players through the modulation of AP.

APS Science 2007.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2008-05-30

This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure,more » each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience.« less

14 CFR 14.10 - Contents of application.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Contents of application. 14.10 Section 14.10 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES RULES IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants...

14 CFR 14.10 - Contents of application.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Contents of application. 14.10 Section 14.10 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES RULES IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants...

14 CFR 14.10 - Contents of application.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Contents of application. 14.10 Section 14.10 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES RULES IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants...

14 CFR 14.10 - Contents of application.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Contents of application. 14.10 Section 14.10 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES RULES IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants...

14 CFR 14.10 - Contents of application.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Contents of application. 14.10 Section 14.10 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES RULES IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants...

75 FR 77598 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-13

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency 44 CFR Part 67 [Docket ID FEMA...: Federal Emergency Management Agency, DHS. ACTION: Proposed rule. SUMMARY: Comments are requested on the... locations in the table below. The BFEs and modified BFEs are a part of the floodplain management measures...

Another Strategy for Teaching Histology to A&P Students: Classification versus Memorization.

ERIC Educational Resources Information Center

Bavis, Ryan W.; Seveyka, Jerred; Shigeoka, Cassie A.

2000-01-01

Defines dichotomous keys as common learning tools based on identification rather than memorization. Provides an example of a dichotomous key developed for introducing histology in human anatomy and physiology (A&P) courses and explains how students can use the dichotomous key. Discusses the goals of the exercises and the process of…

78 FR 14565 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

..., Building and team.com/lomrs.htm. County (12-03- Chairman at Development 1200P). Large, Loudoun Department... D. Public Works, team.com/lomrs.htm. 2078P). Sessoms, Jr., Municipal Center, Mayor, City of Building... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes...

75 FR 3278 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... Boeing 747-8/8F model airplane. [FR Doc. 2010-927 Filed 1-19-10; 8:45 am] BILLING CODE 4910-13-P .... Petitioner: The Boeing Company. Section of 14 CFR Affected: 14 CFR 25.981(a)(3). Description of Relief Sought...

76 FR 60572 - Self-Regulatory Organizations; The Options Clearing Corporation; Order Approving Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

..., 2008), 73 FR 42646 (July 22, 2008) (SR-OCC-2007-20)); give itself time to prepare updated comparative...\\ Proposed Interpretation and Policy .01 to OCC Rule 1001. The new formula is designed to more directly take...\\ \\10\\ Note the comparative data described in this paragraph was obtained using confidence levels set at...

76 FR 40815 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

..., 2010 460046 1172). 08-0269P). November 17, 2010; Krambeck, Mayor, City of The Black Hills Spearfish... Assistance No. 97.022, ``Flood Insurance.'') Dated: June 15, 2011 Sandra K. Knight, Deputy Federal Insurance...

75 FR 63468 - Notice of Revocation of Market-Based Rate Tariff

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... market-based rate tariffs. \\1\\ Electric Quarterly Reports, 132 FERC ] 61,251 (2010) (September 22 Order.... Kimberly D. Bose, Secretary. [FR Doc. 2010-25955 Filed 10-14-10; 8:45 am] BILLING CODE 6717-01-P ...

76 FR 50915 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... indicated on the following table and revise the Flood Insurance Rate Maps (FIRMs) in effect for the listed... Rock, CO 80104. Delaware: Sussex, (FEMA Docket Unincorporated areas June 16, 2010; June The Honorable... 480076 1162). 06-1185P). August 16, 2010; Martin, Mayor, City of The Alvin Sun. Manvel, P.O. Box 187...

VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3

PubMed Central

Li, Haiyan; Santos, Magda S.; Park, Chihyung K.; Dobry, Yuriy; Voglmaier, Susan M.

2017-01-01

Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that broadly distinguishes cortical (VGLUT1) and subcortical (VGLUT2) systems, and correlates with distinct physiological properties in synapses expressing these isoforms. Differential trafficking of VGLUT1 and 2 has been suggested to underlie their functional diversity. Increasing evidence suggests individual synaptic vesicle proteins use specific sorting signals to engage specialized biochemical mechanisms to regulate their recycling. We observed that VGLUT2 recycles differently in response to high frequency stimulation than VGLUT1. Here we further explore the trafficking of VGLUT2 using a pHluorin-based reporter, VGLUT2-pH. VGLUT2-pH exhibits slower rates of both exocytosis and endocytosis than VGLUT1-pH. VGLUT2-pH recycling is slower than VGLUT1-pH in both hippocampal neurons, which endogenously express mostly VGLUT1, and thalamic neurons, which endogenously express mostly VGLUT2, indicating that protein identity, not synaptic vesicle membrane or neuronal cell type, controls sorting. We characterize sorting signals in the C-terminal dileucine-like motif, which plays a crucial role in VGLUT2 trafficking. Disruption of this motif abolishes synaptic targeting of VGLUT2 and essentially eliminates endocytosis of the transporter. Mutational and biochemical analysis demonstrates that clathrin adaptor proteins (APs) interact with VGLUT2 at the dileucine-like motif. VGLUT2 interacts with AP-2, a well-studied adaptor protein for clathrin mediated endocytosis. In addition, VGLUT2 also interacts with the alternate adaptors, AP-1 and AP-3. VGLUT2 relies on distinct recycling mechanisms from VGLUT1. Abrogation of these differences by pharmacological and molecular inhibition reveals that

VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.

PubMed

Li, Haiyan; Santos, Magda S; Park, Chihyung K; Dobry, Yuriy; Voglmaier, Susan M

2017-01-01

Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that broadly distinguishes cortical (VGLUT1) and subcortical (VGLUT2) systems, and correlates with distinct physiological properties in synapses expressing these isoforms. Differential trafficking of VGLUT1 and 2 has been suggested to underlie their functional diversity. Increasing evidence suggests individual synaptic vesicle proteins use specific sorting signals to engage specialized biochemical mechanisms to regulate their recycling. We observed that VGLUT2 recycles differently in response to high frequency stimulation than VGLUT1. Here we further explore the trafficking of VGLUT2 using a pHluorin-based reporter, VGLUT2-pH. VGLUT2-pH exhibits slower rates of both exocytosis and endocytosis than VGLUT1-pH. VGLUT2-pH recycling is slower than VGLUT1-pH in both hippocampal neurons, which endogenously express mostly VGLUT1, and thalamic neurons, which endogenously express mostly VGLUT2, indicating that protein identity, not synaptic vesicle membrane or neuronal cell type, controls sorting. We characterize sorting signals in the C-terminal dileucine-like motif, which plays a crucial role in VGLUT2 trafficking. Disruption of this motif abolishes synaptic targeting of VGLUT2 and essentially eliminates endocytosis of the transporter. Mutational and biochemical analysis demonstrates that clathrin adaptor proteins (APs) interact with VGLUT2 at the dileucine-like motif. VGLUT2 interacts with AP-2, a well-studied adaptor protein for clathrin mediated endocytosis. In addition, VGLUT2 also interacts with the alternate adaptors, AP-1 and AP-3. VGLUT2 relies on distinct recycling mechanisms from VGLUT1. Abrogation of these differences by pharmacological and molecular inhibition reveals that

75 FR 5930 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-05

... include BFEs located on the stream reach between the referenced locations above. Please refer to the... 20472. ADDRESSES City of Fort Ransom Maps are available for inspection at P.O. Box 17, Fort Ransom, ND 58033. City of Lisbon Maps are available for inspection at P.O. Box 1079, Lisbon, ND 58054...

78 FR 3041 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

... marital relationships. The circumstances requiring an applicant to submit documentary evidence of marriage are prescribed in 20 CFR 219.30. In the absence of documentary evidence, the RRB needs to determine if..., Chief of Information Resources Management. [FR Doc. 2013-00613 Filed 1-14-13; 8:45 am] BILLING CODE 7905...

75 FR 28227 - National Emission Standards for Hazardous Air Pollutants: Gold Mine Ore Processing and Production...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... published a proposed rule for mercury emissions from the gold mine ore processing and production area source... proposed rule (75 FR 22470). Several parties requested that EPA extend the comment period. EPA has granted...-AP48 National Emission Standards for Hazardous Air Pollutants: Gold Mine Ore Processing and Production...

77 FR 71404 - Intent To Prepare an Environmental Impact Statement for the Proposed Flood Risk Management Study...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... Policy Act (NEPA) of 1969 as implemented by the Council on Environmental Quality regulations (40 CFR... specifically, this document will discuss measures to improve flood risk management, navigation, water quality.... The overall goal of the study is to reduce flood risk by saving lives and minimizing property damage...

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

PubMed

Tomlinson, Ian P M; Webb, Emily; Carvajal-Carmona, Luis; Broderick, Peter; Howarth, Kimberley; Pittman, Alan M; Spain, Sarah; Lubbe, Steven; Walther, Axel; Sullivan, Kate; Jaeger, Emma; Fielding, Sarah; Rowan, Andrew; Vijayakrishnan, Jayaram; Domingo, Enric; Chandler, Ian; Kemp, Zoe; Qureshi, Mobshra; Farrington, Susan M; Tenesa, Albert; Prendergast, James G D; Barnetson, Rebecca A; Penegar, Steven; Barclay, Ella; Wood, Wendy; Martin, Lynn; Gorman, Maggie; Thomas, Huw; Peto, Julian; Bishop, D Timothy; Gray, Richard; Maher, Eamonn R; Lucassen, Anneke; Kerr, David; Evans, D Gareth R; Schafmayer, Clemens; Buch, Stephan; Völzke, Henry; Hampe, Jochen; Schreiber, Stefan; John, Ulrich; Koessler, Thibaud; Pharoah, Paul; van Wezel, Tom; Morreau, Hans; Wijnen, Juul T; Hopper, John L; Southey, Melissa C; Giles, Graham G; Severi, Gianluca; Castellví-Bel, Sergi; Ruiz-Ponte, Clara; Carracedo, Angel; Castells, Antoni; Försti, Asta; Hemminki, Kari; Vodicka, Pavel; Naccarati, Alessio; Lipton, Lara; Ho, Judy W C; Cheng, K K; Sham, Pak C; Luk, J; Agúndez, Jose A G; Ladero, Jose M; de la Hoya, Miguel; Caldés, Trinidad; Niittymäki, Iina; Tuupanen, Sari; Karhu, Auli; Aaltonen, Lauri; Cazier, Jean-Baptiste; Campbell, Harry; Dunlop, Malcolm G; Houlston, Richard S

2008-05-01

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition.

Power Saving Control for Battery-Powered Portable WLAN APs

NASA Astrophysics Data System (ADS)

Ogawa, Masakatsu; Hiraguri, Takefumi

This paper proposes a power saving control function for battery-powered portable wireless LAN (WLAN) access points (APs) to extend the battery life. The IEEE802.11 standard does not support power saving control for APs. To enable a sleep state for an AP, the AP forces the stations (STAs) to refrain from transmitting frames using the network allocation vector (NAV) while the AP is sleeping. Thus the sleep state for the AP can be employed without causing frame loss at the STAs. Numerical analysis and computer simulation reveal that the newly proposed control technique conserves power compared to the conventional control.

78 FR 20331 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-04

... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes............ 350070 (12-06-1488P). David Coss, Avenue, Santa Fe, team.com/lomrs.htm. Mayor, City of NM 87501. Santa Fe... Design http://www.rampp- May 28, 2013......... 405381 06-1019P). Dewey F. Office, 2317 team.com/lomrs.htm...

A paradoxical increase of a metabolite upon increased expression of its catabolic enzyme: the case of diadenosine tetraphosphate (Ap4A) and Ap4A phosphorylase I in Saccharomyces cerevisiae.

PubMed Central

Avila, D M; Robinson, A K; Kaushal, V; Barnes, L D

1991-01-01

The APA1 gene in Saccharomyces cerevisiae encodes Ap4A phosphorylase I, the catabolic enzyme for diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A). APA1 has been inserted into a multicopy plasmid and into a centromeric plasmid with a GAL1 promoter. Enhanced expression of APA1 via the plasmids resulted in 10- and 90-fold increases in Ap4A phosphorylase activity, respectively, as assayed in vitro. However, the intracellular concentration of Ap4A exhibited increases of 2- and 15-fold, respectively, from the two different plasmids. Intracellular Ap4A increased 3- to 20-fold during growth on galactose of a transformant with APA1 under the control of the GAL1 promoter. Intracellular adenosine 5'-P1-tetraphospho-P4-5"'-guanosine (Ap4G) and diguanosine 5',5"'-P1,P4-tetraphosphate (Gp4G) also increased in the transformant under these conditions. The chromosomal locus of APA1 has been disrupted in a haploid strain. The Ap4A phosphorylase activity decreased by 80% and the intracellular Ap4A concentration increased by a factor of five in the null mutant. These results with the null mutant agree with previous results reported by Plateau et al. (P. Plateau, M. Fromant, J.-M. Schmitter, J.-M. Buhler, and S. Blancquet, J. Bacteriol. 171:6437-6445, 1989). The paradoxical increase in Ap4A upon enhanced expression of APA1 indicates that the metabolic consequences of altered gene expression may be more complex than indicated solely by assay of enzymatic activity of the gene product. PMID:1660456

A paradoxical increase of a metabolite upon increased expression of its catabolic enzyme: the case of diadenosine tetraphosphate (Ap4A) and Ap4A phosphorylase I in Saccharomyces cerevisiae.

PubMed

Avila, D M; Robinson, A K; Kaushal, V; Barnes, L D

1991-12-01

The APA1 gene in Saccharomyces cerevisiae encodes Ap4A phosphorylase I, the catabolic enzyme for diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A). APA1 has been inserted into a multicopy plasmid and into a centromeric plasmid with a GAL1 promoter. Enhanced expression of APA1 via the plasmids resulted in 10- and 90-fold increases in Ap4A phosphorylase activity, respectively, as assayed in vitro. However, the intracellular concentration of Ap4A exhibited increases of 2- and 15-fold, respectively, from the two different plasmids. Intracellular Ap4A increased 3- to 20-fold during growth on galactose of a transformant with APA1 under the control of the GAL1 promoter. Intracellular adenosine 5'-P1-tetraphospho-P4-5"'-guanosine (Ap4G) and diguanosine 5',5"'-P1,P4-tetraphosphate (Gp4G) also increased in the transformant under these conditions. The chromosomal locus of APA1 has been disrupted in a haploid strain. The Ap4A phosphorylase activity decreased by 80% and the intracellular Ap4A concentration increased by a factor of five in the null mutant. These results with the null mutant agree with previous results reported by Plateau et al. (P. Plateau, M. Fromant, J.-M. Schmitter, J.-M. Buhler, and S. Blancquet, J. Bacteriol. 171:6437-6445, 1989). The paradoxical increase in Ap4A upon enhanced expression of APA1 indicates that the metabolic consequences of altered gene expression may be more complex than indicated solely by assay of enzymatic activity of the gene product.

14th-16th century Danube floods and long-term water-level changes reflected in archaeological-sedimentary evidence - in comparison with documentary evidence

NASA Astrophysics Data System (ADS)

Kiss, Andrea; Laszlovszky, József

2014-05-01

In the present paper an overview of published and unpublished results of archaeological and sedimentary investigations, predominantly reflect on 14th-16th-century changes, are provided and compared to documentary information on flood events and long-term changes. Long-term changes in flood behaviour and average water-level conditions had long-term detectable impacts on sedimentation and fluvio-morphological processes. Moreover, the available archaeological evidence might also provide information on the reaction of the society, in the form of changes in settlement organisation, building structures and processes. At present, information is mainly available concerning the 16th, and partly to the 14th-15th centuries. Medium and short term evidence mainly corresponds to the main flood peaks or even to single catastrophic flood events. Such processes may be identified in archaeological evidence concerning the second half of the 14th, early 15th centuries; while most of the cases listed above were connected to the flood peak (and/or generally increasing water-level conditions) of the late 15th and early 16th centuries. In other cases connections between sedimentary/archaeological evidence and the mid- and late 16th-century high flood-frequency period were presumed. Documentary evidence referring to the same period suggests that higher flood frequency and intensity periods occurred in the early and mid 16th century; a probably more prolonged flood rich period took place in the second half of the 16th century, with a peak in the late 1560s-early 1570s and maybe with another at the end of the 16th century. Earlier flood peaks in documentary evidence were detected on the Danube at the turn of the 14th-15th centuries and in the last decades of the 15th century, continuing in the early 16th century.

Flooding and Clostridium difficile Infection: A Case-Crossover Analysis.

PubMed

Lin, Cynthia J; Wade, Timothy J; Hilborn, Elizabeth D

2015-06-17

Clostridium difficile is a bacterium that can spread by water. It often causes acute gastrointestinal illness in older adults who are hospitalized and/or receiving antibiotics; however, community-associated infections affecting otherwise healthy individuals have become more commonly reported. A case-crossover study was used to assess emergency room (ER) and outpatient visits for C. difficile infection following flood events in Massachusetts from 2003 through 2007. Exposure status was based on whether or not a flood occurred prior to the case/control date during the following risk periods: 0-6 days, 7-13 days, 14-20 days, and 21-27 days. Fixed-effects logistic regression was used to estimate the risk of diagnosis with C. difficile infection following a flood. There were 129 flood events and 1575 diagnoses of C. difficile infection. Among working age adults (19-64 years), ER and outpatient visits for C. difficile infection were elevated during the 7-13 days following a flood (Odds Ratio, OR = 1.69; 95% Confidence Interval, CI: 0.84, 3.37). This association was more substantial among males (OR = 3.21; 95% CI: 1.01-10.19). Associations during other risk periods were not observed (p < 0.05). Although we were unable to differentiate community-associated versus nosocomial infections, a potential increase in C. difficile infections should be considered as more flooding is projected due to climate change.

Silencing of P2Y2 receptor delays Ap4A-corneal re-epithelialization process

PubMed Central

Crooke, Almudena; Mediero, Aránzazu; Guzmán-Aránguez, Ana

2009-01-01

Purpose There are no selective antagonists for the metabotropic nucleotide P2Y2 receptor subtype. This implies that it is not possible to demonstrate the importance of such a receptor in the relevant process of corneal wound healing. Therefore, we have cloned and designed a small interference RNA (siRNA) against the rabbit P2Y2 receptor (P2Y2-R) mRNA, which clearly demonstrates the importance of this receptor in the process of wound healing triggered by nucleotides and dinucleotides both in vitro and in vivo. Methods Rabbit P2Y2-R cDNA was cloned using a combination of degenerate reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE). To test the efficacy of synthesized siRNAs targeting P2Y2-R, immunocytochemistry, immunohistochemistry, and quantitative RT-PCR (qRT–PCR) assays were performed. Migration assays were performed both in vitro and in vivo by wounding the epithelium with a pipette tip and n-heptanol, respectively. These wounds were performed 72 h after siRNA transfection either in the presence or the absence of the P2Y2 agonist, 100 μM Ap4A (diadenosine tetraphosphate). Results The cloned receptor presents 93% homology compared to the human gene. Two siRNAs were designed and synthesized against a rabbit P2Y2-R sequence. After transfection (in vitro assays) or topical instillation (in vivo assays), we demonstrated P2Y2-R siRNA efficient transfection/delivery and its efficient gene silencing. Clear reduction of P2Y2-R expression was observed at both the mRNA and protein levels in corneas treated with siRNA. In vitro and in vivo migration analysis showed that the silencing process has concomitantly reduced the ability of corneal cells to close the wounds in the presence of the Ap4A. In addition, both synthesized siRNAs exert a delay effect on the Ap4A-induced migration rate in vitro. These results suggest the absence of non-specific (off-target) effects by our siRNA. Conclusions The application of P2Y2-R si

Silencing of P2Y2 receptor delays Ap4A-corneal re-epithelialization process.

PubMed

Crooke, Almudena; Mediero, Aránzazu; Guzmán-Aránguez, Ana; Pintor, Jesús

2009-06-11

There are no selective antagonists for the metabotropic nucleotide P2Y(2) receptor subtype. This implies that it is not possible to demonstrate the importance of such a receptor in the relevant process of corneal wound healing. Therefore, we have cloned and designed a small interference RNA (siRNA) against the rabbit P2Y(2) receptor (P2Y(2)-R) mRNA, which clearly demonstrates the importance of this receptor in the process of wound healing triggered by nucleotides and dinucleotides both in vitro and in vivo. Rabbit P2Y(2)-R cDNA was cloned using a combination of degenerate reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE). To test the efficacy of synthesized siRNAs targeting P2Y(2)-R, immunocytochemistry, immunohistochemistry, and quantitative RT-PCR (qRT-PCR) assays were performed. Migration assays were performed both in vitro and in vivo by wounding the epithelium with a pipette tip and n-heptanol, respectively. These wounds were performed 72 h after siRNA transfection either in the presence or the absence of the P2Y(2) agonist, 100 muM Ap(4)A (diadenosine tetraphosphate). The cloned receptor presents 93% homology compared to the human gene. Two siRNAs were designed and synthesized against a rabbit P2Y(2)-R sequence. After transfection (in vitro assays) or topical instillation (in vivo assays), we demonstrated P2Y(2)-R siRNA efficient transfection/delivery and its efficient gene silencing. Clear reduction of P2Y(2)-R expression was observed at both the mRNA and protein levels in corneas treated with siRNA. In vitro and in vivo migration analysis showed that the silencing process has concomitantly reduced the ability of corneal cells to close the wounds in the presence of the Ap(4)A. In addition, both synthesized siRNAs exert a delay effect on the Ap(4)A-induced migration rate in vitro. These results suggest the absence of non-specific (off-target) effects by our siRNA. The application of P2Y(2)-R siRNA has

Cellular microRNA miR-10a-5p inhibits replication of porcine reproductive and respiratory syndrome virus by targeting the host factor signal recognition particle 14.

PubMed

Zhao, Guangwei; Hou, Jianye; Xu, Gaoxiao; Xiang, Aoqi; Kang, Yanmei; Yan, Yunhuan; Zhang, Xiaobin; Yang, Gongshe; Xiao, Shuqi; Sun, Shiduo

2017-04-01

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viruses affecting the swine industry worldwide. MicroRNAs have recently been demonstrated to play vital roles in virus-host interactions. Our previous research on small RNA deep sequencing showed that the expression level of miR-10a increased during the viral life cycle. The present study sought to determine the function of miR-10a and its molecular mechanism during PRRSV infection. In the current study, the result of PRRSV infection inducing miR-10a expression was validated by quantitative reverse transcriptase PCR. Overexpression of miR-10a-5p using its mimics markedly reduced the expression level of intracellular PRRSV ORF7 mRNA and N protein. Simultaneously, overexpression of miR-10a-5p also significantly decreased the expression level of extracellular viral RNA and virus titres in the supernatants. These results demonstrated that miR-10a-5p could suppress the replication of PRRSV. A direct interaction between miR-10a-5p and signal recognition particle 14 (SRP14) was confirmed using bioinformatic prediction and experimental verification. miR-10a-5p could directly target the 3'UTR of pig SRP14 mRNA in a sequence-specific manner and decrease SRP14 expression through translational repression but not mRNA degradation. Further, knockdown of SRP14 by small interfering RNA also inhibits the replication of PRRSV. Collectively, these results suggested that miR-10a-5p inhibits PRRSV replication through suppression of SRP14 expression, which not only provides new insights into virus-host interactions during PRRSV infection but also suggests potential new antiviral strategies against PRRSV infection.

The use of water marks mapping to understand flood overflow events inside karstic cavities: Cueva Fría and Cueva Rosa (Asturias, NW Spain)

NASA Astrophysics Data System (ADS)

González Lemos, Saúl; Stoll, Heather M.

2014-05-01

Several karst systems in Asturias (NW Spain) present evidence of fluvial deposits cemented in speleothems that may provide good chronology of past flood events inside the caves. This flood record is under research in two karstic caves of this region, Cueva Fría and Cueva Rosa, which have in common the presence of a perennial stream inside the cave and a low gradient of the cave passage. Immediately after a flood overflow event, water marks, foam and detritus are visible at different heights on the cave walls and correspond to heights of bottlenecks in overflow drainage through the cave passage. Flood events also deposit sand and gravel on terraces on the cave wall and move large volumes of sand in the cave bed. We have noted that detrital particles (like sand or silt particles) are preserved as inclusions inside the stalagmites and that their abundance inside coeval stalagmites decreases as altitude and distance from the perennial stream increase, supporting its fluvial affinity. However, not all the stalagmites that contain detrital particles are located close to the perennial streams. In this work, we have mapped the water marks preserved in the cave walls to reconstruct water levels associated to flood overflow events of different magnitude. We have found that water mark correlation along the cave passage is very useful to define the hydrological behaviour and flood model of the cave during these extreme events. The water mark mapping and correlation have been also useful to prove that during periods of high rainfall, the movement of the sand-bars inside the cave can cover partially or completely active stalagmites, facilitating the cementation process and trapping abundant detrital material inside the stalagmite carbonate. 14C and U/Th dating of the stalagmites can provide a chronology for the detrital rich layers, so that the abundance of fluvial material in the stalagmites can reveal periods of enhanced vs. reduced flooding in the cave over the past several

Simulations of Flooding on Pea River and Whitewater Creek in the Vicinity of the Proposed Elba Bypass at Elba, Alabama

USGS Publications Warehouse

Hedgecock, T. Scott

2003-01-01

A two-dimensional finite-element surface-water model was used to study the effects of proposed modifications to the State Highway 203 corridor (proposed Elba Bypass/relocated U.S. Highway 84) on water-surface elevations and flow distributions during flooding in the Pea River and Whitewater Creek Basins at Elba, Coffee County, Alabama. Flooding was first simulated for the March 17, 1990, flood, using the 1990 flood-plain conditions to calibrate the model to match measured data collected by the U.S. Geological Survey and the U.S. Army Corps of Engineers after the flood. After model calibration, the effects of flooding were simulated for four scenarios: (1) floods having the 50- and 100-year recurrence intervals for the existing flood-plain, bridge, highway, and levee conditions; (2) floods having the 50- and 100-year recurrence intervals for the existing flood-plain and levee conditions with the State Highway 203 embankment and bridge removed; (3) floods having the 50- and 100-year recurrence intervals for the existing flood-plain, bridge, and highway conditions with proposed modifications (elevating) to the levee; and (4) floods having the 50- and 100-year recurrence intervals for the proposed conditions reflecting the Elba Bypass and modified levee. The simulation of floodflow for the Pea River and Whitewater Creek flood of March 17, 1990, in the study reach compared closely to flood profile data obtained after the flood. The flood of March 17, 1990, had an estimated peak discharge of 58,000 cubic feet per second at the gage (just below the confluence) and was estimated to be between a 50-year and 100-year flood event. The estimated peak discharge for Pea River and Whitewater Creek was 40,000 and 42,000 cubic feet per second, respectively. Simulation of floodflows for the 50-year flood (51,400 cubic feet per second) at the gage for existing flood-plain, bridge, highway, and levee conditions indicated that about 31 percent of the peak flow was conveyed by the State

Hypermethylation of AP-2Alpha as a Prognostic Marker for DCIS

DTIC Science & Technology

2008-05-01

Unfortunately, among the methylation status of the AP2, CYCLIN D, ECAD , GSTP, and SSOCS genes, either as individual genes, or in combinations, no...0.61 to 4.10) 1.00 (referent) 0.35 ECAD M UM 0 100 3 97 GSTP M UM 40 60 24 76 2.02 (0.72 to 5.64) 1.00...Missing data: 1.4% for AP2, CYCLIN D, ECAD , GSTP; 4.2% for SSOCS; 2.8% for nuclear grade. §M=methylated; UM=unmethylated; +Two-sided

78 FR 45938 - Final Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

...] Final Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final notice. SUMMARY: Flood hazard determinations, which may include additions or modifications of Base Flood Elevations (BFEs), base flood depths, Special Flood Hazard Area (SFHA) boundaries or zone designations, or...

78 FR 31899 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2013-OS-0111] Proposed Collection; Comment Request AGENCY: Defense Logistics Agency, DoD. ACTION: Notice. SUMMARY: In compliance with Section... Siegel, Alternate OSD Federal Register Liaison Officer, Department of Defense. [FR Doc. 2013-12549 Filed...

78 FR 21143 - Final Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

... County, South Carolina, and Incorporated Areas Docket No.: FEMA-B-1251 City of Manning 29 West Boyce Street, Manning, SC 29102. Town of Summerton 10 West Main Street, Summerton, SC 29148. Town of Turbeville..., County. Manning, SC 29102. (Catalog of Federal Domestic Assistance No. 97.022, ``Flood Insurance.'') Roy...

77 FR 64330 - Notice of Proposed Information Collection Requests; Institute of Education Sciences; 2012/14...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-19

... DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Institute of Education Sciences; 2012/14 Beginning Postsecondary Students Longitudinal Study: (BPS:12/14) Field Test SUMMARY: The... comment period will not be accepted. Written requests for information or comments submitted by postal mail...

Impact of the proposed I-326 crossing on the 500-year flood stages of the Congaree River near Columbia, South Carolina

USGS Publications Warehouse

Bennett, C.S.

1984-01-01

A two-dimensional finite-element surface water flow modeling system based on the shallow water equations was used to study the hydraulic impact of the proposed Interstate crossing on the 500-year flood. Infrared aerial photography was used to define regions of homogeneous roughness in the flood plain. Finite-element networks approximating flood plain topography were designed using elements of three roughness types. High water marks established during an 8-year flood that occurred in October 1976 were used to calibrate the model. The 500-year flood (630,000 cu ft/sec) was simulated using the dike on the left bank as the left boundary and the right edge of the flood plain as the right boundary. Simulations were performed without and with the proposed highway embankments in place. Detailed information was obtained about backwater effects upstream from the proposed highway embankments, changes in flow distribution resulting from embankments, and velocities in the vicinity of the bridge openings. The results of the study indicate that the four bridge openings in the right flood plain should be adequate to handle the 500-yr flood flow. Forty percent of the flow passes through the main channel bridge, while the remaining 60% of the flow passes through the three overflow bridges. Average velocities in the bridge openings ranged from 3.4 ft/sec to 6.9 ft/sec with a maximum vertically averaged velocity of 9.3 ft/sec occurring at the right edge of one of the overflow bridges. (Author 's abstract)

44 CFR 65.11 - Evaluation of sand dunes in mapping coastal flood hazard areas.

Code of Federal Regulations, 2010 CFR

2010-10-01

... storm-induced dune erosion potential in its determination of coastal flood hazards and risk mapping... base flood storm surges and associated wave action where the cross-sectional area of the primary... storm surges and associated wave action. [53 FR 16279, May 6, 1988] ...

44 CFR 65.11 - Evaluation of sand dunes in mapping coastal flood hazard areas.

Code of Federal Regulations, 2013 CFR

2013-10-01

... storm-induced dune erosion potential in its determination of coastal flood hazards and risk mapping... base flood storm surges and associated wave action where the cross-sectional area of the primary... storm surges and associated wave action. [53 FR 16279, May 6, 1988] ...

44 CFR 65.11 - Evaluation of sand dunes in mapping coastal flood hazard areas.

Code of Federal Regulations, 2012 CFR

2012-10-01

... storm-induced dune erosion potential in its determination of coastal flood hazards and risk mapping... base flood storm surges and associated wave action where the cross-sectional area of the primary... storm surges and associated wave action. [53 FR 16279, May 6, 1988] ...

44 CFR 65.11 - Evaluation of sand dunes in mapping coastal flood hazard areas.

Code of Federal Regulations, 2014 CFR

2014-10-01

... storm-induced dune erosion potential in its determination of coastal flood hazards and risk mapping... base flood storm surges and associated wave action where the cross-sectional area of the primary... storm surges and associated wave action. [53 FR 16279, May 6, 1988] ...

44 CFR 65.11 - Evaluation of sand dunes in mapping coastal flood hazard areas.

Code of Federal Regulations, 2011 CFR

2011-10-01

... storm-induced dune erosion potential in its determination of coastal flood hazards and risk mapping... base flood storm surges and associated wave action where the cross-sectional area of the primary... storm surges and associated wave action. [53 FR 16279, May 6, 1988] ...

Update on the development of cotton gin PM10 emission factors for EPA's AP-42

USDA-ARS?s Scientific Manuscript database

A cotton ginning industry-supported project was initiated in 2008 to update the U.S. Environmental Protection Agency’s (EPA) Compilation of Air Pollution Emission Factors (AP-42) to include PM10 emission factors. This study develops emission factors from the PM10 emission factor data collected from ...

77 FR 8826 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2008-OS-0043] Proposed Collection; Comment Request AGENCY: Office of the Under Secretary of Defense (Personnel and Readiness), DoD. ACTION...: January 12, 2012. Patricia L. Toppings, OSD Federal Register Liaison Officer, Department of Defense. [FR...

Development of cotton gin PM10 emission factors for EPA’s AP-42

USDA-ARS?s Scientific Manuscript database

The Compilation of Air Pollution Emission Factors (AP-42) emission factors are assigned ratings, from A (Excellent) to E (Poor), based on the quality of data used to develop them. All current PM10 cotton gin emission factors received quality ratings of D or lower. In an effort to improve these ratin...

Aqueous flooding methods for tertiary oil recovery

DOEpatents

Peru, Deborah A.

1989-01-01

A method of aqueous flooding of subterranean oil bearing formation for tertiary oil recovery involves injecting through a well into the formation a low alkaline pH aqueous sodium bicarbonate flooding solution. The flooding solution's pH ranges from about 8.25 to 9.25 and comprises from 0.25 to 5 weight percent and preferably about 0.75 to 3.0 weight percent of sodium bicarbonate and includes a petroleum recovery surfactant of 0.05 to 1.0 weight percent and between 1 and 20 weight percent of sodium chloride. After flooding, an oil and water mixture is withdrawn from the well and the oil is separated from the oil and water mixture.

Development of a national Flash flood warning system in France using the AIGA method: first results and main issues

NASA Astrophysics Data System (ADS)

Javelle, Pierre; Organde, Didier; Demargne, Julie; de Saint-Aubin, Céline; Garandeau, Léa; Janet, Bruno; Saint-Martin, Clotilde; Fouchier, Catherine

2016-04-01

Developing a national flash flood (FF) warning system is an ambitious and difficult task. On one hand it rises huge expectations from exposed populations and authorities since induced damages are considerable (ie 20 casualties in the recent October 2015 flood at the French Riviera). But on the other hand, many practical and scientific issues have to be addressed and limitations should be clearly stated. The FF warning system to be implemented by 2016 in France by the SCHAPI (French national service in charge of flood forecasting) will be based on a discharge-threshold flood warning method called AIGA (Javelle et al. 2014). The AIGA method has been experimented in real time in the south of France in the RHYTMME project (http://rhytmme.irstea.fr). It consists in comparing discharges generated by a simple conceptual hourly hydrologic model run at a 1-km² resolution to reference flood quantiles of different return periods, at any point along the river network. The hydrologic model ingests operational rainfall radar-gauge products from Météo-France. Model calibration was based on ~700 hydrometric stations over the 2002-2015 period and then hourly discharges were computed at ~76 000 catchment outlets, with areas ranging from 10 to 3 500 km², over the last 19 years. This product makes it possible to calculate reference flood quantiles at each outlet. The on-going evaluation of the FF warnings is currently made at two levels: in a 'classical' way, using discharges available at the hydrometric stations, but also in a more 'exploratory' way, by comparing past flood reports and warnings issued by the system over the 76 000 catchment outlets. The interest of the last method is that it better fit the system objectives since it is designed to monitor small ungauged catchments. Javelle, P., Demargne, J., Defrance, D, .Pansu, J, .Arnaud, P. (2014). Evaluating flash-flood warnings at ungauged locations using post-event surveys: a case study with the AIGA warning system

78 FR 48150 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-07

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DoD-2013-OS-0170] Proposed Collection..., Alternate OSD Federal Register Liaison Officer, Department of Defense. [FR Doc. 2013-18991 Filed 8-6-13; 8...), ATTN: Chris Cothran, 2743 Defense Boulevard, SW Washington, DC 20373-5815. Title; Associated Form; and...

Simulations of the effects of U.S. Highway 231 and the proposed Montgomery outer loop on flooding in the Catoma Creek and Little Catoma Creek Basins near Montgomery, Alabama

USGS Publications Warehouse

Hedgecock, T. Scott

1999-01-01

.5 feet, respectively. For the 500-year flood, no overtopping of U.S. Highway 231 occurred. Simulation of the 100-year floodflow for Little Catoma Creek for the proposed conditions indicates that, for the existing bridges on U.S. Highway 231, 54 percent of the flow (8,190 cubic feet per second) was conveyed by the northernmost bridge, 22 percent (3,350 cubic feet per second) by the middle bridge, and 24 percent (3,490 cubic feet per second) by the southernmost bridge. The two proposed relief bridges on the Montgomery Outer Loop upstream from the proposed remaining catfish ponds conveyed about 7,750 cubic feet per second (3,400 cubic feet per second for the west relief bridge and 4,350 cubic feet per second for the east relief bridge) with an average depth of flow of about 7 feet. The average water-surface elevation at the upstream limit of the study reach for Little Catoma Creek was 218.8 feet, which is about 0.5 foot higher than the average water-surface elevation for the existing conditions. For the 100-year flood, there was no overtopping of either U.S. Highway 231 or the Montgomery Outer Loop. However, the levees of the proposed remaining catfish ponds were completely overtopped. For the Montgomery Outer Loop crossing of Catoma Creek, simulation of the 100-year floodflow indicates that about 58 percent of the flow (14,100 cubic feet per second) was conveyed by the proposed main channel bridge and 42 percent (10,200 cubic feet per second) by the proposed relief bridge. The average water-surface elevation at the upstream limit of the study reach for Catoma Creek was 216.9 feet, which is the same as the water-surface elevation for the existing conditions. Results of model simulations for the 500-year flood for the proposed conditions indicate that there was no overtopping on either U.S. Highway 231 or the Montgomery Outer Loop. For the existing bridges on U.S. Highway 231, 42 percent of the flow (11,300 cubic feet per second) was conveyed by the northernmost bridge

Planetary radar targets 1999 AP10, 2000 TO64, 2000 UJ1, and 2000 XK44: Four S-complex near-Earth asteroids.

NASA Astrophysics Data System (ADS)

Hicks, M.; Lawrence, K.

2009-12-01

We report taxonomic classifications of four near-Earth asteroids (1999 AP10, 2000 TO64, 2000 UJ1, and 2000 XK44) scheduled for radar observation by the JPL radar group at the Arecibo facility in Oct-Nov 2009, using long-slit CCD spectroscopy acquired at the Palomar 5-m telescope on 2009 Nov 09 UT. Table 1 lists the observation circumstances. Normalized reflectance spectra are shown in Figures 1-4 [1]Flood risk assessment in France: comparison of extreme flood estimation methods (EXTRAFLO project, Task 7)

NASA Astrophysics Data System (ADS)

Garavaglia, F.; Paquet, E.; Lang, M.; Renard, B.; Arnaud, P.; Aubert, Y.; Carre, J.

2013-12-01

In flood risk assessment the methods can be divided in two families: deterministic methods and probabilistic methods. In the French hydrologic community the probabilistic methods are historically preferred to the deterministic ones. Presently a French research project named EXTRAFLO (RiskNat Program of the French National Research Agency, https://extraflo.cemagref.fr) deals with the design values for extreme rainfall and floods. The object of this project is to carry out a comparison of the main methods used in France for estimating extreme values of rainfall and floods, to obtain a better grasp of their respective fields of application. In this framework we present the results of Task 7 of EXTRAFLO project. Focusing on French watersheds, we compare the main extreme flood estimation methods used in French background: (i) standard flood frequency analysis (Gumbel and GEV distribution), (ii) regional flood frequency analysis (regional Gumbel and GEV distribution), (iii) local and regional flood frequency analysis improved by historical information (Naulet et al., 2005), (iv) simplify probabilistic method based on rainfall information (i.e. Gradex method (CFGB, 1994), Agregee method (Margoum, 1992) and Speed method (Cayla, 1995)), (v) flood frequency analysis by continuous simulation approach and based on rainfall information (i.e. Schadex method (Paquet et al., 2013, Garavaglia et al., 2010), Shyreg method (Lavabre et al., 2003)) and (vi) multifractal approach. The main result of this comparative study is that probabilistic methods based on additional information (i.e. regional, historical and rainfall information) provide better estimations than the standard flood frequency analysis. Another interesting result is that, the differences between the various extreme flood quantile estimations of compared methods increase with return period, staying relatively moderate up to 100-years return levels. Results and discussions are here illustrated throughout with the example

77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... DEPARTMENT OF EDUCATION Application for New Awards; Advanced Placement (AP) Test Fee Program--Reopening the AP Test Fee Fiscal Year 2012 Competition AGENCY: Office of Elementary and Secondary Education (OESE), Department of Education. ACTION: Notice reopening the AP Test Fee fiscal year 2012 competition...

P alpha-chiral phosphorothioate analogues of bis(5'-adenosyl)tetraphosphate (Ap4A); their enzymatic synthesis and degradation.

PubMed Central

Lazewska, D; Guranowski, A

1990-01-01

the Ap4A-metabolizing enzymes with respect to the potential substrates modified at the Ap4A-P alpha are discussed. PMID:2172926

Base (100-year) flood elevations for selected sites in Marion County, Missouri

USGS Publications Warehouse

Southard, Rodney E.; Wilson, Gary L.

1998-01-01

The primary requirement for community participation in the National Flood Insurance Program is the adoption and enforcement of floodplain management requirements that minimize the potential for flood damages to new construction and avoid aggravating existing flooding conditions. This report provides base flood elevations (BFE) for a 100-year recurrence flood for use in the management and regulation of 14 flood-hazard areas designated by the Federal Emergency Management Agency as approximate Zone A areas in Marion County, Missouri. The one-dimensional surface-water flow model, HEC-RAS, was used to compute the base (100-year) flood elevations for the 14 Zone A sites. The 14 sites were located at U.S., State, or County road crossings and the base flood elevation was determined at the upstream side of each crossing. The base (100-year) flood elevations for BFE 1, 2, and 3 on the South Fork North River near Monroe City, Missouri, are 627.7, 579.2, and 545.9 feet above sea level. The base (100-year) flood elevations for BFE 4, 5, 6, and 7 on the main stem of the North River near or at Philadelphia and Palmyra, Missouri, are 560.5, 539.7, 504.2, and 494.4 feet above sea level. BFE 8 is located on Big Branch near Philadelphia, a tributary to the North River, and the base (100-year) flood elevation at this site is 530.5 feet above sea level. One site (BFE 9) is located on the South River near Monroe City, Missouri. The base (100-year) flood elevation at this site is 619.1 feet above sea level. Site BFE 10 is located on Bear Creek near Hannibal, Missouri, and the base (100-year) elevation is 565.5 feet above sea level. The four remaining sites (BFE 11, 12, 13, and 14) are located on the South Fabius River near Philadelphia and Palmyra, Missouri. The base (100-year) flood elevations for BFE 11, 12, 13, and 14 are 591.2, 578.4, 538.7, and 506.9 feet above sea level.

A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins

PubMed Central

Negishi, Masamitsu; Wongpalee, Somsakul P.; Sarkar, Sukumar; Park, Jonghoon; Lee, Kyung Yong; Shibata, Yoshiyuki; Reon, Brian J.; Abounader, Roger; Suzuki, Yutaka; Sugano, Sumio; Dutta, Anindya

2014-01-01

Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cell physiology, but many of which have no known function. CDKN1A/p21 is an important inhibitor of the cell-cycle, regulator of the DNA damage response and effector of the tumor suppressor p53, playing a crucial role in tumor development and prevention. In order to identify a regulator for tumor progression, we performed an siRNA screen of human lncRNAs required for cell proliferation, and identified a novel lncRNA, APTR, that acts in trans to repress the CDKN1A/p21 promoter independent of p53 to promote cell proliferation. APTR associates with the promoter of CDKN1A/p21 and this association requires a complementary-Alu sequence encoded in APTR. A different module of APTR associates with and recruits the Polycomb repressive complex 2 (PRC2) to epigenetically repress the p21 promoter. A decrease in APTR is necessary for the induction of p21 after heat stress and DNA damage by doxorubicin, and the levels of APTR and p21 are anti-correlated in human glioblastomas. Our data identify a new regulator of the cell-cycle inhibitor CDKN1A/p21 that acts as a proliferative factor in cancer cell lines and in glioblastomas and demonstrate that Alu elements present in lncRNAs can contribute to targeting regulatory lncRNAs to promoters. PMID:24748121

78 FR 18966 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... DEPARTMENT OF DEFENSE Department of the Air Force [Docket ID USAF-2013-0022] Proposed Collection; Comment Request AGENCY: Department of Defense/Department of the Air Force/National Museum of the United..., Alternate OSD Federal Liaison Officer, Department of Defense. [FR Doc. 2013-07170 Filed 3-27-13; 8:45 am...

44 CFR 9.10 - Identify impacts of proposed actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... consider whether the proposed action will result in an increase in the useful life of any structure or facility in question, maintain the investment at risk and exposure of lives to the flood hazard or forego... lives and property and on natural and beneficial floodplain and wetland values; and the three categories...

44 CFR 9.10 - Identify impacts of proposed actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... consider whether the proposed action will result in an increase in the useful life of any structure or facility in question, maintain the investment at risk and exposure of lives to the flood hazard or forego... lives and property and on natural and beneficial floodplain and wetland values; and the three categories...

44 CFR 9.10 - Identify impacts of proposed actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... consider whether the proposed action will result in an increase in the useful life of any structure or facility in question, maintain the investment at risk and exposure of lives to the flood hazard or forego... lives and property and on natural and beneficial floodplain and wetland values; and the three categories...

44 CFR 9.10 - Identify impacts of proposed actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... consider whether the proposed action will result in an increase in the useful life of any structure or facility in question, maintain the investment at risk and exposure of lives to the flood hazard or forego... lives and property and on natural and beneficial floodplain and wetland values; and the three categories...

44 CFR 9.10 - Identify impacts of proposed actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... consider whether the proposed action will result in an increase in the useful life of any structure or facility in question, maintain the investment at risk and exposure of lives to the flood hazard or forego... lives and property and on natural and beneficial floodplain and wetland values; and the three categories...

10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

Code of Federal Regulations, 2013 CFR

2013-01-01

... design, in accordance with 10 CFR part 52, subpart B. The applicant for certification of the AP600 design... appendix. B. Generic technical specifications means the information, required by 10 CFR 50.36 and 50.36a... licensee must meet the requirement in Section III.B of this appendix to reference Tier 2 when referencing...

Flooding and Clostridium difficile Infection: A Case-Crossover Analysis

PubMed Central

Lin, Cynthia J.; Wade, Timothy J.; Hilborn, Elizabeth D.

2015-01-01

Clostridium difficile is a bacterium that can spread by water. It often causes acute gastrointestinal illness in older adults who are hospitalized and/or receiving antibiotics; however, community-associated infections affecting otherwise healthy individuals have become more commonly reported. A case-crossover study was used to assess emergency room (ER) and outpatient visits for C. difficile infection following flood events in Massachusetts from 2003 through 2007. Exposure status was based on whether or not a flood occurred prior to the case/control date during the following risk periods: 0–6 days, 7–13 days, 14–20 days, and 21–27 days. Fixed-effects logistic regression was used to estimate the risk of diagnosis with C. difficile infection following a flood. There were 129 flood events and 1575 diagnoses of C. difficile infection. Among working age adults (19–64 years), ER and outpatient visits for C. difficile infection were elevated during the 7–13 days following a flood (Odds Ratio, OR = 1.69; 95% Confidence Interval, CI: 0.84, 3.37). This association was more substantial among males (OR = 3.21; 95% CI: 1.01–10.19). Associations during other risk periods were not observed (p < 0.05). Although we were unable to differentiate community-associated versus nosocomial infections, a potential increase in C. difficile infections should be considered as more flooding is projected due to climate change. PMID:26090609

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

PubMed Central

Timofeeva, Maria N.; Hung, Rayjean J.; Rafnar, Thorunn; Christiani, David C.; Field, John K.; Bickeböller, Heike; Risch, Angela; McKay, James D.; Wang, Yufei; Dai, Juncheng; Gaborieau, Valerie; McLaughlin, John; Brenner, Darren; Narod, Steven A.; Caporaso, Neil E.; Albanes, Demetrius; Thun, Michael; Eisen, Timothy; Wichmann, H.-Erich; Rosenberger, Albert; Han, Younghun; Chen, Wei; Zhu, Dakai; Spitz, Margaret; Wu, Xifeng; Pande, Mala; Zhao, Yang; Zaridze, David; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Krokan, Hans E.; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Vatten, Lars; Njølstad, Inger; Chen, Chu; Goodman, Gary; Lathrop, Mark; Benhamou, Simone; Vooder, Tõnu; Välk, Kristjan; Nelis, Mari; Metspalu, Andres; Raji, Olaide; Chen, Ying; Gosney, John; Liloglou, Triantafillos; Muley, Thomas; Dienemann, Hendrik; Thorleifsson, Gudmar; Shen, Hongbing; Stefansson, Kari; Brennan, Paul; Amos, Christopher I.; Houlston, Richard; Landi, Maria Teresa

2012-01-01

Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21–6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P = 7.2 × 10−16), 6p21 (P = 2.3 × 10−14) and 15q25 (P = 2.2 × 10−63). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16INK4A/p14ARF/CDKN2B/p15INK4B/ANRIL; rs1333040, P = 3.0 × 10−7) which was replicated in a series of 5415 Han Chinese (P = 0.03; combined analysis, P = 2.3 × 10−8). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer. PMID:22899653

Beyond 'flood hotspots': Modelling emergency service accessibility during flooding in York, UK

NASA Astrophysics Data System (ADS)

Coles, Daniel; Yu, Dapeng; Wilby, Robert L.; Green, Daniel; Herring, Zara

2017-03-01

This paper describes the development of a method that couples flood modelling with network analysis to evaluate the accessibility of city districts by emergency responders during flood events. We integrate numerical modelling of flood inundation with geographical analysis of service areas for the Ambulance Service and the Fire & Rescue Service. The method was demonstrated for two flood events in the City of York, UK to assess the vulnerability of care homes and sheltered accommodation. We determine the feasibility of emergency services gaining access within the statutory 8- and 10-min targets for high-priority, life-threatening incidents 75% of the time, during flood episodes. A hydrodynamic flood inundation model (FloodMap) simulates the 2014 pluvial and 2015 fluvial flood events. Predicted floods (with depth >25 cm and areas >100 m2) were overlain on the road network to identify sites with potentially restricted access. Accessibility of the city to emergency responders during flooding was quantified and mapped using; (i) spatial coverage from individual emergency nodes within the legislated timeframes, and; (ii) response times from individual emergency service nodes to vulnerable care homes and sheltered accommodation under flood and non-flood conditions. Results show that, during the 2015 fluvial flood, the area covered by two of the three Fire & Rescue Service stations reduced by 14% and 39% respectively, while the remaining station needed to increase its coverage by 39%. This amounts to an overall reduction of 6% and 20% for modelled and observed floods respectively. During the 2014 surface water flood, 7 out of 22 care homes (32%) and 15 out of 43 sheltered accommodation nodes (35%) had modelled response times above the 8-min threshold from any Ambulance station. Overall, modelled surface water flooding has a larger spatial footprint than fluvial flood events. Hence, accessibility of emergency services may be impacted differently depending on flood mechanism

Flash flood warnings for ungauged basins based on high-resolution precipitation forecasts

NASA Astrophysics Data System (ADS)

Demargne, Julie; Javelle, Pierre; Organde, Didier; de Saint Aubin, Céline; Janet, Bruno

2016-04-01

ingested as time-lagged ensembles. The time-lagged approach is a practical choice of accounting for the atmospheric forecast uncertainty when no extensive forecast archive is available for statistical modelling. The evaluation on 185 basins in the South of France showed significant improvements in terms of flash flood event detection and effective warning lead-time, compared to warnings from the current AIGA setup (without any future precipitation). Various verification metrics (e.g., Relative Mean Error, Brier Skill Score) show the skill of ensemble precipitation and flow forecasts compared to single-valued persistency benchmarks. Planned enhancements include integrating additional probabilistic NWP products (e.g., AROME precipitation ensembles on longer forecast horizon), accounting for and reducing hydrologic uncertainties from the model parameters and initial conditions via data assimilation, and developing a comprehensive observational and post-event damage database to determine decision-relevant warning thresholds for flood magnitude and probability. Javelle, P., Demargne, J., Defrance, D., Arnaud, P., 2014. Evaluating flash flood warnings at ungauged locations using post-event surveys: a case study with the AIGA warning system. Hydrological Sciences Journal, doi: 10.1080/02626667.2014.923970 Auger, L., Dupont, O., Hagelin, S., Brousseau, P., Brovelli, P., 2015. AROME-NWC: a new nowcasting tool based on an operational mesoscale forecasting system. Quarterly Journal of the Royal Meteorological Society, 141: 1603-1611, doi: 10.1002/qj.2463

Solar modulation of flood frequency in Central Europe during spring and summer on inter-annual to millennial time-scales

NASA Astrophysics Data System (ADS)

Czymzik, M.; Muscheler, R.; Brauer, A.

2015-10-01

Solar influences on climate variability are one of the most controversially discussed topics in climate research. We analyze solar forcing of flood frequency in Central Europe on inter-annual to millennial time-scales using daily discharge data of River Ammer (southern Germany) back to AD 1926 and revisiting the 5500 year flood layer time-series from varved sediments of the downstream Lake Ammersee. Flood frequency in the discharge record is significantly correlated to changes in solar activity during solar cycles 16-23 (r = -0.47, p < 0.0001, n = 73). Flood layer frequency (n = 1501) in the sediment record depicts distinct multi-decadal variability and significant correlations to 10Be fluxes from a Greenland ice core (r = 0.45, p < 0.0001) and 14C production rates (r =0.36, p < 0.0001), proxy records of solar activity. Flood frequency is higher when solar activity is reduced. These correlations between flood frequency and solar activity might provide empirical support for the solar top-down mechanism expected to modify the mid-latitude storm tracks over Europe by model studies. A lag of flood frequency responses in the Ammer discharge record to changes in solar activity of about one to three years could be explained by a modelled ocean-atmosphere feedback delaying the atmospheric reaction to solar activity variations up to a few years.

10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

Code of Federal Regulations, 2014 CFR

2014-01-01

... design, in accordance with 10 CFR part 52, subpart B. The applicant for certification of the AP600 design....55(b) and 52.57(b). This appendix remains valid for an applicant or licensee who references this.... Exemptions from Tier 1 information are governed by the requirements in 10 CFR 52.63(b)(1) and 52.98(f). The...

24 CFR 10.14 - Hearings.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Hearings. 10.14 Section 10.14... RULEMAKING: POLICY AND PROCEDURES Procedures § 10.14 Hearings. (a) The provisions of 5 U.S.C. 556 and 557, which govern formal hearings in adjudicatory proceedings, do not apply to informal rule making...

24 CFR 10.14 - Hearings.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Hearings. 10.14 Section 10.14... RULEMAKING: POLICY AND PROCEDURES Procedures § 10.14 Hearings. (a) The provisions of 5 U.S.C. 556 and 557, which govern formal hearings in adjudicatory proceedings, do not apply to informal rule making...

24 CFR 10.14 - Hearings.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Hearings. 10.14 Section 10.14... RULEMAKING: POLICY AND PROCEDURES Procedures § 10.14 Hearings. (a) The provisions of 5 U.S.C. 556 and 557, which govern formal hearings in adjudicatory proceedings, do not apply to informal rule making...

75 FR 81589 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 11 a.m., Friday, January 14, 2011. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS.... [FR Doc. 2010-32781 Filed 12-23-10; 4:15 pm] BILLING CODE 6351-01-P ...

75 FR 43941 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meetings TIME AND DATE: 11 a.m., Friday, August 14, 2010. PLACE: 1155 21st St., NW., Washington, DC, 9th Floor Commission Conference Room. STATUS.... [FR Doc. 2010-18493 Filed 7-23-10; 4:15 pm] BILLING CODE 6351-01-P ...

7 CFR 3411.14 - Proposal review.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal review. 3411.14 Section 3411.14 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL RESEARCH INITIATIVE COMPETITIVE GRANTS PROGRAM Scientific Peer...

7 CFR 3415.14 - Proposal review.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal review. 3415.14 Section 3415.14 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer...

78 FR 29760 - Final Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-21

... accordance with section 110 of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR part 67...] Final Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final Notice. SUMMARY: Flood hazard determinations, which may include additions or modifications of Base Flood...

Model simulations of potential contribution of the proposed Huangpu Gate to flood control in the Lake Taihu basin of China

NASA Astrophysics Data System (ADS)

Zhang, Hanghui; Liu, Shuguang; Ye, Jianchun; Yeh, Pat J.-F.

2017-10-01

The Lake Taihu basin (36 895 km2), one of the most developed regions in China located in the hinterland of the Yangtze River Delta, has experienced increasing flood risk. The largest flood in history occurred in 1999 with a return period estimate of 200 years, considerably larger than the current capacity of the flood defense with a design return period of 50 years. Due to its flat saucer-like terrain, the capacity of the flood control system in this basin depends on flood control infrastructures and peripheral tidal conditions. The Huangpu River, an important river of the basin connecting Lake Taihu upstream and Yangtze River estuaries downstream, drains two-fifths of the entire basin. Since the water level in the Huangpu River is significantly affected by the high tide conditions in estuaries, constructing an estuary gate is considered an effective solution for flood mitigation. The main objective of this paper is to assess the potential contributions of the proposed Huangpu Gate to the flood control capacity of the basin. To achieve this goal, five different scenarios of flooding conditions and the associated gate operations are considered by using numerical model simulations. Results of quantitative analyses show that the Huangpu Gate is effective for evacuating floodwaters. It can help to reduce both peak values and duration of high water levels in Lake Taihu to benefit surrounding areas along the Taipu Canal and the Huangpu River. The contribution of the gate to the flood control capacity is closely associated with its operation modes and duration. For the maximum potential contribution of the gate, the net outflow at the proposed site is increased by 52 %. The daily peak level is decreased by a maximum of 0.12 m in Lake Taihu, by maxima of 0.26-0.37 and 0.46-0.60 m in the Taipu Canal and the Huangpu River, respectively, and by 0.05-0.39 m in the surrounding areas depending on the local topography. It is concluded that the proposed Huangpu Gate can reduce

78 FR 14573 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... Municipal team.com/lomrs.htm. Mayor, City of Building, 503 Waynesboro, 503 West Main Street, West Main... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes... http://www.rampp- April 22, 2013......... 050192 06-0842P). Mattingly, Mayor, Street, Benton, team.com...

77 FR 59953 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... areas of Terry L. Baker, Administration team.com/lomrs.htm. Washington County President, Building, 100... Jackson Township http://www.rampp- November 26, 2012.... 421805 (12-03-0843P). O. Moyer, Building, 60 team... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes...

76 FR 58409 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-21

... changes in BFEs are in accordance with 44 CFR 65.4. National Environmental Policy Act. This interim rule is categorically excluded from the requirements of 44 CFR part 10, Environmental Consideration. An environmental impact assessment has not been prepared. Regulatory Flexibility Act. As flood elevation...

Proactive AP Selection Method Considering the Radio Interference Environment

NASA Astrophysics Data System (ADS)

Taenaka, Yuzo; Kashihara, Shigeru; Tsukamoto, Kazuya; Yamaguchi, Suguru; Oie, Yuji

In the near future, wireless local area networks (WLANs) will overlap to provide continuous coverage over a wide area. In such ubiquitous WLANs, a mobile node (MN) moving freely between multiple access points (APs) requires not only permanent access to the Internet but also continuous communication quality during handover. In order to satisfy these requirements, an MN needs to (1) select an AP with better performance and (2) execute a handover seamlessly. To satisfy requirement (2), we proposed a seamless handover method in a previous study. Moreover, in order to achieve (1), the Received Signal Strength Indicator (RSSI) is usually employed to measure wireless link quality in a WLAN system. However, in a real environment, especially if APs are densely situated, it is difficult to always select an AP with better performance based on only the RSSI. This is because the RSSI alone cannot detect the degradation of communication quality due to radio interference. Moreover, it is important that AP selection is completed only on an MN, because we can assume that, in ubiquitous WLANs, various organizations or operators will manage APs. Hence, we cannot modify the APs for AP selection. To overcome these difficulties, in the present paper, we propose and implement a proactive AP selection method considering wireless link condition based on the number of frame retransmissions in addition to the RSSI. In the evaluation, we show that the proposed AP selection method can appropriately select an AP with good wireless link quality, i.e., high RSSI and low radio interference.

75 FR 67086 - Proposed Subsequent Arrangement

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-01

... Cooperation Concerning Civil Uses of Nuclear Energy Between the Government of the United States of America and the Government of Canada and the Agreement for Cooperation in the Peaceful Uses of Nuclear Energy... Department of Energy. Thomas P. D'Agostino, Administrator, National Nuclear Security Administration. [FR Doc...

75 FR 67086 - Proposed Subsequent Arrangement

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-01

... Cooperation Concerning Civil Uses of Nuclear Energy Between the Government of the United States of America and the Government of Canada and the Agreement for Cooperation in the Peaceful Uses of Nuclear Energy... Energy. Thomas P. D'Agostino, Administrator, National Nuclear Security Administration. [FR Doc. 2010...

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus.

PubMed

Mutso, Margit; Morro, Ainhoa Moliner; Smedberg, Cecilia; Kasvandik, Sergo; Aquilimeba, Muriel; Teppor, Mona; Tarve, Liisi; Lulla, Aleksei; Lulla, Valeria; Saul, Sirle; Thaa, Bastian; McInerney, Gerald M; Merits, Andres; Varjak, Margus

2018-04-27

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus replicase. These proteins also interact with numerous host proteins and some crucial interactions are mediated by the unstructured C-terminal hypervariable domain (HVD) of nsP3. In this study, a human cell line expressing EGFP tagged with CHIKV nsP3 HVD was established. Using quantitative proteomics, it was found that CHIKV nsP3 HVD can bind cytoskeletal proteins, including CD2AP, SH3KBP1, CAPZA1, CAPZA2 and CAPZB. The interaction with CD2AP was found to be most evident; its binding site was mapped to the second SH3 ligand-like element in nsP3 HVD. Further assessment indicated that CD2AP can bind to nsP3 HVDs of many different New and Old World alphaviruses. Mutation of the short binding element hampered the ability of the virus to establish infection. The mutation also abolished ability of CD2AP to co-localise with nsP3 and replication complexes of CHIKV; the same was observed for Semliki Forest virus (SFV) harbouring a similar mutation. Similar to CD2AP, its homolog SH3KBP1 also bound the identified motif in CHIKV and SFV nsP3.

7 CFR 3415.14 - Proposal review.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Proposal review. 3415.14 Section 3415.14 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications...

75 FR 22771 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... effective 4/14/2010. Filed Date: 04/15/2010. Accession Number: 20100415-5095. Comment Date: 5 p.m. Eastern... on Friday, May 7, 2010. Docket Numbers: ER10-1060-000. Applicants: Southern California Edison Company... TTY, call (202) 502-8659. Nathaniel J. Davis, Sr., Deputy Secretary. [FR Doc. 2010-10077 Filed 4-29-10...

Resistance on Aisle Three?: Exploring the Big Curriculum of Consumption and the (Im)Possibility of Resistance in John Updike's "A&P"

ERIC Educational Resources Information Center

Stearns, Jennie; Sandlin, Jennifer A.; Burdick, Jake

2011-01-01

In this article, we examine John Updike's short story "A&P" and its depiction of the grocery store as a curricular space re/presenting consumption and resistance to it. We position Updike's fictional A&P as a space where the "big curriculum" (Schubert, 2006a) of consumption is enacted in everyday life and explore both how the curriculum of…

78 FR 8174 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... Smaligo, Chairman, Building, 633 West team.com/lomrs.hrm. County (12-06- Tulsa County Board 3rd Street... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes....rampp- March 28, 2013 400360 Collinsville (12- Weaver, Mayor, Street, team.com/lomrs.hrm. 06-4005P...

78 FR 8170 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... Development team.com/ of Sachse, 3815 Department, 3815 lomrs.htm. Sachse Road, Sachse Road, Building B... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes... http://www.rampp- March 7, 2013 350146 (12-06-2669P). Thomas E. Civic Center team.com/ Swisstack, Mayor...

78 FR 35305 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

....rampp- August 12, 2013 350002 Albuquerque, (12- Richard J. Berry, Building team.com/ 06-3488P). Mayor... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes... 420 West Main http://www.rampp- August 12, 2013 405378 City,. Cornett, Mayor, Street, Suite team.com...

78 FR 48885 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

...- August 12, 2013...... 420713 Whitpain (12-03- Joseph J. Palmer, Building, 960 team.com/lomrs.htm. 1849P... team.com/lomrs.htm. City of Sachse, Department, 5560 3815 Sachse Road, Highway 78, Building B, Sachse... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes...

77 FR 77081 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... Regulations (44 CFR part 65). The LOMR will be used by insurance agents and others to calculate appropriate flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes... of North Pinal Supervisors, P.O. Street, Building Box 827, F, Florence, AZ Florence, AZ 85232. 85132...

76 FR 39009 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... buildings. The changes in BFEs are in accordance with 44 CFR 65.4. National Environmental Policy Act. This final rule is categorically excluded from the requirements of 44 CFR part 10, Environmental Consideration. An environmental impact assessment has not been prepared. Regulatory Flexibility Act. As flood...

Ap4A is not an efficient Zn(II) binding agent. A concerted potentiometric, calorimetric and NMR study.

PubMed

Wszelaka-Rylik, Małgorzata; Witkiewicz-Kucharczyk, Aleksandra; Wójcik, Jacek; Bal, Wojciech

2007-05-01

Diadenosine 5',5''-P(1)P(4) tetraphosphate (Ap(4)A) has been considered as an intracellular partner for Zn(II). We applied potentiometry, ITC and NMR to study protonation equilibria of Ap(4)A and Zn(II) complexation by this dinucleotide. The values of binding constants obtained by these three techniques under various experimental conditions coherently demonstrated that Ap(4)A binds Zn(II) weakly, with an apparent binding constant of ca. 10(4) at neutral pH. Such a low stability of Zn(II) complexes with Ap(4)A excludes a possibility for interactions between these two agents in vivo.

7 CFR 3411.14 - Proposal review.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Proposal review. 3411.14 Section 3411.14 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE NATIONAL RESEARCH INITIATIVE COMPETITIVE GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3411...

Study and proposals related to extensive flooding in the Siret River area during the summer of 2008 in Romania

NASA Astrophysics Data System (ADS)

Stefanescu, Victor; Stefan, Sabina; Irimescu, Anisoara

2010-05-01

Extensive flooding due to overflowing of the Siret River and associated runoff in smaller rivers in northeastern Romania at the end of July 2008 are discussed, taking into account the meteorological and hydrological contexts. The flooding events in Romania claimed human deaths and population displacement, large-scale destruction of housing and infrastructure. Although the Siret river is quite shallow, and several dams and reservoirs restrict and control its flow, the area along the river remains prone to periodic flooding, mainly in spring and summer. Several observations are made on the viability of settlements close to Siret riverbed in Romania, related to the repeatability of situations such as that during the summer of 2008. Generally, the relative shallowness of the river Siret may cause flash floods, when its level increases rapidly due to abundant precipitation. As such, the horizontal extent of the flooding due to runoff is a factor seemingly more important than the short-lived increases in depth, combined with the speed of the flow. As a direct result of the flooding, crops and buildings were damaged. The probability that similar meteorological contexts can cause flooding with the extent of that in 2008 will be discussed. Also, some possible means to improve the reaction of authorities and delivery of relief by them to the affected population will be proposed. Regarding the meteorological context, a presentation of the cyclonic system that has brought heavy and/or continuous rain in northern and northeastern Romania will be made. As proposal for improving the delivery of resources toward the affected area and population, a software system designed to shorten the process of conveying relevant information to decisional factors, and to increase the speed of information between interesed parties will be discussed. The possible outcome of this specific case study will be the improvement of the decisional flux required in times of natural disasters, flooding

Artificial pancreas (AP) clinical trial participants' acceptance of future AP technology.

PubMed

Bevier, Wendy C; Fuller, Serena M; Fuller, Ryan P; Rubin, Richard R; Dassau, Eyal; Doyle, Francis J; Jovanovič, Lois; Zisser, Howard C

2014-09-01

Artificial pancreas (AP) systems are currently an active field of diabetes research. This pilot study examined the attitudes of AP clinical trial participants toward future acceptance of the technology, having gained firsthand experience. After possible influencers of AP technology adoption were considered, a 34-question questionnaire was developed. The survey assessed current treatment satisfaction, dimensions of clinical trial participant motivation, and variables of the technology acceptance model (TAM). Forty-seven subjects were contacted to complete the survey. The reliability of the survey scales was tested using Cronbach's α. The relationship of the factors to the likelihood of AP technology adoption was explored using regression analysis. Thirty-six subjects (76.6%) completed the survey. Of the respondents, 86.1% were either highly likely or likely to adopt the technology once available. Reliability analysis of the survey dimensions revealed good internal consistency, with scores of >0.7 for current treatment satisfaction, convenience (motivation), personal health benefit (motivation), perceived ease of use (TAM), and perceived usefulness (TAM). Linear modeling showed that future acceptance of the AP was significantly associated with TAM and the motivation variables of convenience plus the individual item benefit to others (R(2)=0.26, P=0.05). When insulin pump and continuous glucose monitor use were added, the model significance improved (R(2)=0.37, P=0.02). This pilot study demonstrated that individuals with direct AP technology experience expressed high likelihood of future acceptance. Results support the factors of personal benefit, convenience, perceived usefulness, and perceived ease of use as reliable scales that suggest system adoption in this highly motivated patient population.

44 CFR 65.16 - Standard Flood Hazard Determination Form and Instructions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance.... Finally, the form is available through the Internet at http://www.fema.gov/nfip/mpurfi.htm. [63 FR 27857...

44 CFR 65.16 - Standard Flood Hazard Determination Form and Instructions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance.... Finally, the form is available through the Internet at http://www.fema.gov/nfip/mpurfi.htm. [63 FR 27857...

44 CFR 65.16 - Standard Flood Hazard Determination Form and Instructions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance.... Finally, the form is available through the Internet at http://www.fema.gov/nfip/mpurfi.htm. [63 FR 27857...

77 FR 70495 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... reporting burden of 322 hours (2 hours per response x 161 responses). Written comments are invited on: (a...'Neill, Deputy Secretary. [FR Doc. 2012-28530 Filed 11-23-12; 8:45 am] BILLING CODE 8011-01-P ...

78 FR 32676 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-31

... flood insurance premium rates for new buildings and the contents of those buildings. For rating purposes...://www.rampp-team.com/ September 23, 2013........ 050084 Springs (13-06- Ruth Carney, 111 Opera lomrs.htm... http://www.rampp-team.com/ July 25, 2013 340343 Hanover (12-02- Ronald F. Engineering lomrs.htm. 1077P...

Effects of the tripeptide substance P antagonist, FR113680, on airway constriction and airway edema induced by neurokinins in guinea-pigs.

PubMed

Murai, M; Morimoto, H; Maeda, Y; Fujii, T

1992-06-24

FR113680 is a newly developed tripeptide substance P (SP) receptor antagonist. The effects of FR113680 on airway constriction and airway edema induced by neurokinins were investigated in guinea-pigs. In in vitro experiments, FR113680 inhibited the contraction of isolated guinea-pig trachea induced by SP and neurokinin A (NKA) in a dose-dependent manner with IC50 values of 2.3 x 10(-6) and 1.5 x 10(-5) M, respectively. The tracheal contraction induced by histamine and acetylcholine was not affected by FR113680. FR113680 (5 x 10(-5) M) also significantly inhibited the atropine-resistant contraction of isolated guinea-pig bronchi induced by electrical field stimulation. In in vivo experiments, FR113680 given i.v. inhibited SP-induced airway constriction in guinea-pigs at doses of 1 and 10 mg kg-1. However, FR113680 only inhibited NKA- and capsaicin-induced airway constriction by 40-50% even at a dose of 10 mg kg-1. FR113680 also inhibited SP-induced airway edema in guinea-pigs with the same potency as it inhibited SP-induced airway constriction. Histamine-induced airway constriction and airway edema were not affected at a dose of 10 mg kg-1. These results suggest that FR113680 preferentially inhibits responses induced by NK1 receptor activation (SP-induced airway constriction and airway edema), but is less effective on a NK2 receptor-induced response (airway constriction by NKA and neurogenic stimulation).

75 FR 75945 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... CFR part 10, Environmental Consideration. An environmental impact assessment has not been prepared... mile of Skagit County. east of Beaver Marsh Road. Approximately 1,600 feet 3 +19 east of the intersection of Beaver Marsh Road and Marsh Road. [[Page 75948

75 FR 15422 - Proposed Agency Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-29

...) Information Collection Request Title: Batteries; (3) Type of Review: Emergency; (4) Purpose: To collect data... Technology, Office of Energy Efficiency and Renewable Energy. [FR Doc. 2010-6877 Filed 3-26-10; 8:45 am...

76 FR 36044 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

..., Environmental Consideration. An environmental impact assessment has not been prepared. Regulatory Flexibility... Communities affected in meters (MSL) Effective Modified Kane County, Illinois, and Incorporated Areas Big Rock... Jericho Road (at the of Big Rock. Kendall County boundary). Approximately 1.0 mile None +689 upstream of...

SU-E-T-14: A Feasibility Study of Using Modified AP Proton Beam for Post-Operative Pancreatic Cancer Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ding, X; Witztum, A; Kenton, O

2014-06-01

Purpose: Due to the unpredictability of bowel gas movement, the PA beam direction is always favored for robust proton therapy in post-operative pancreatic cancer treatment. We investigate the feasibility of replacing PA beam with a modified AP beam to take the bowel gas uncertainty into account. Methods: Nine post-operative pancreatic cancer patients treated with proton therapy (5040cGy, 28 fractions) in our institution were randomly selected. The original plan uses PA and lateral direction passive-scattering proton beams. Beam weighting is about 1:1. All patients received weekly verification CTs to assess the daily variations(total 17 verification CTs). The PA direction beam wasmore » replaced by two other groups of AP direction beam. Group AP: takes 3.5% range uncertainty into account. Group APmod: compensates the bowel gas uncertainty by expanding the proximal margin to 2cm more. The 2cm margin was acquired from the average bowel diameter in from 100 adult abdominal CT scans near pancreatic region (+/- 5cm superiorly and inferiorly). Dose Volume Histograms(DVHs) of the verification CTs were acquired for robustness study. Results: Without the lateral beam, Group APmod is as robust as Group PA. In Group AP, more than 10% of iCTV D98/D95 were reduced by 4–8%. LT kidney and Liver dose robustness are not affected by the AP/PA beam direction. There is 10% of chance that RT kidney and cord will be hit by AP proton beam due to the bowel gas. Compared to Group PA, APmod plan reduced the dose to kidneys and cord max significantly, while there is no statistical significant increase in bowel mean dose. Conclusion: APmod proton beam for the target coverage could be as robust as the PA direction without sacrificing too much of bowel dose. When the AP direction beam has to be selected, a 2cm proximal margin should be considered.« less

7 CFR 3400.14 - Proposal review.

Code of Federal Regulations, 2012 CFR

2012-01-01

... RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3400.14 Proposal review. (a... review will be made for responsiveness to the request for proposals (e.g., relationship of application to... carefully reviewed by the Director, qualified officers or employees of the Department, the respective peer...

7 CFR 3400.14 - Proposal review.

Code of Federal Regulations, 2014 CFR

2014-01-01

... RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3400.14 Proposal review. (a... review will be made for responsiveness to the request for proposals (e.g., relationship of application to... carefully reviewed by the Director, qualified officers or employees of the Department, the respective peer...

7 CFR 3400.14 - Proposal review.

Code of Federal Regulations, 2013 CFR

2013-01-01

... RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3400.14 Proposal review. (a... review will be made for responsiveness to the request for proposals (e.g., relationship of application to... carefully reviewed by the Director, qualified officers or employees of the Department, the respective peer...

76 FR 62329 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-07

...] Communities affected elevation * * Elevation in meters (MSL) Effective Modified Anne Arundel County, Maryland... + 8 + 10 Unincorporated Areas of Crain Highway. Anne Arundel County. Approximately 400 feet None + 105... American Vertical Datum. [caret] Mean Sea Level, rounded to the nearest 0.1 meter. * * BFEs to be changed...

77 FR 55862 - Notice of Lodging of Proposed Consent Judgment Under the Resource Recovery and Conservation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

...., Whitestone Gasoline, Inc., Java Gasoline, Inc., BBZZ Equities, Inc., 21st Century Fuel, LLC, A Penny Less..., Environment and Natural Resources Division. [FR Doc. 2012-22273 Filed 9-10-12; 8:45 am] BILLING CODE 4410-15-P ...

Rhizosphere dynamics of two riparian plant species from the water fluctuation zone of Three Gorges Reservoir, P.R. China - pH, oxygen and LMWOA monitoring during short flooding events

NASA Astrophysics Data System (ADS)

Schreiber, Christina M.; Schurr, Ulrich; Zeng, Bo; Höltkemeier, Agnes; Kuhn, Arnd J.

2010-05-01

Since the construction of the Three Gorges Dam at the Yangtze River in China, the reservoir management created a new 30m water fluctuation zone 45-75m above the original water level. Only species well adapted to long-time flooding (up to several months) will be able to vegetate the river banks and replace the original vegetation. To investigate how common species of the riverbanks cope with submergence, Alternanthera philoxeroides Mart. and Arundinella anomala Steud., two flooding resistant riparian species, have been examined in a rhizotron environment. Short-time (2 days waterlogging, 2 days flooding, 2 days recovery) flooding cycles in the original substrate and long time (14 days waterlogging, flooding, recovery) flooding cycles, in original substrate and sterile glass bead substrate, have been simulated in floodable two-way access rhizotrons. Oxygen- and pH-sensitive foils (planar optodes, PreSens) automatically monitored root reaction in a confined space (2cm2 each) on the backside of the rhizotron, while soil solution samples were taken 2 times a day from the other side of the rhizotron at the corresponding area through filter and steel capillaries. The samples were analyzed by capillary electrophoresis for low molecular weight organic acids (LMWOA, i.e. oxalic, formic, succinic, malic, acetic, glyoxylic, lactic and citric acid). Results show diurnal rhythms of rhizospheric acidification for both species in high resolution, combined with oxygen entry into the root surrounding during waterlogged state. Flooding caused stronger acidification in the rhizosphere, that were however not accompanied by increased occurrence of LMWOA except for acetic and glyoxylic acid. First results from longer flooding periods show stable diurnal rhythms during waterlogging, but no strongly increased activity during the flooding event. Performance of the two species is not hampered by being waterlogged, and they follow a silencing strategy during a longer phase of anoxia without

7 CFR 3400.14 - Proposal review.

Code of Federal Regulations, 2011 CFR

2011-01-01

... RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3400.14 Proposal review. (a... review will be made for responsiveness to the request for proposals (e.g., relationship of application to... peer review group, and ad hoc reviewers, as required. Written comments will be solicited from ad hoc...

75 FR 61371 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... Black Creek Approximately 1.9 mile None +581 City of Trussville, downstream of Whites Town of Argo, Town.... Approximately 0.3 mile None +695 upstream of Kelly Creek Road. Little Black Creek Approximately 110 feet None... County. Approximately 2.5 miles None +860 upstream of the railroad. Middle Black Creek Approximately 1.0...

Minnesota River at Chaska, Minnesota, Flood Control. Final Environmental Impact Statement.

DTIC Science & Technology

1975-07-01

and 10 acres of floodplain wetland interspersed with bottouland trees.J IAN is03 ~ UNCLASSIFIED >ZD D W 3 W ~ a " r I n w a s s O ft t f r a S &c u m A...T C L M P IC A? I O W O f! ThU S C A B S ( M an WS. S w r Drainage of about 30 acres ot wetland WOU14 be cmpeted by the Last Claek bypasschanne. ada...Final Statement to CEQ: ii "WJI RO:N:TAL I.WACT STATMM1N2 FLOOD JOXTPOLFO AT M IIIEZOTA. 14INESOTA RIVEP TAbLk OF C::,Er SUMMAY ENVI ROU *rA. 0-AX: I

78 FR 27 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-02

...-2012-0003] Final Flood Elevation Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final rule. SUMMARY: Base (1% annual-chance) Flood Elevations (BFEs) and modified BFEs are made... effect in order to qualify or remain qualified for participation in the National Flood Insurance Program...

75 FR 78926 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-17

...-2010-0003] Final Flood Elevation Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final rule. SUMMARY: Base (1% annual-chance) Flood Elevations (BFEs) and modified BFEs are made... effect in order to qualify or remain qualified for participation in the National Flood Insurance Program...

77 FR 74610 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

...-2012-0003] Final Flood Elevation Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final rule. SUMMARY: Base (1% annual-chance) Flood Elevations (BFEs) and modified BFEs are made... effect in order to qualify or remain qualified for participation in the National Flood Insurance Program...

76 FR 44276 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

... Fe, NM 87504. Oklahoma: Cleveland City of Norman (10-06- October 6, 2010; The Honorable Cindy S. September 29, 2010 400046 1004P). October 13, 2010; Rosenthal, Mayor, City The Norman of Norman, 201 West Gray Transcript. Street, Norman, OK 73069. Kay City of Ponca City March 14, 2011; The Honorable Homer...

Instructional Design Changes in an Undergraduate A&P Course to Facilitate Student Engagement and Interest

ERIC Educational Resources Information Center

Hurtt, Barbekka; Bryant, Jennifer

2016-01-01

We describe changes in an undergraduate anatomy and physiology (A&P) curriculum designed to address educational goals at a private, comprehensive university. Educational goals included making course material more relevant to students' future career interests, exposing students to professionals in their careers of interest, and incorporating…

Influence of diadenosine tetraphosphate (Ap4A) on lipid metabolism.

PubMed

Rüsing, D; Verspohl, E J

2004-01-01

Diadenosine polyphosphates (Ap(x)A) are physiologically released and may be partly involved in the pathogenesis of diabetes mellitus. Ap(4)A (diadenosine tetraphosphate) leads to an increase in blood glucose while it decreases insulin levels in plasma. A possible link between Ap(x)A and diabetes mellitus-associated diseases such as insulin resistance and hyperlipidemia (plasma free fatty acids, cholesterol and its biosynthesis, triacylglycerols) has not been investigated yet. Parameters such as free fatty acid and cholesterol content in blood were determined enzymically. The biosynthesis of cholesterol and triacylglycerols was determined in HepG2 cells using the radioactive precursor [(14)C]-acetate and by using gas chromatography. Plasma free fatty acids were significantly decreased 5 and 10 min after an Ap(4)A bolus (0.75 mg kg(-1) b.w.) given to rats. Plasma cholesterol was reduced 5 and 60 min after Ap(4)A administration. LPDS (lipoprotein-deficient serum)-stimulated cholesterol biosynthesis in HepG2 cells was significantly reduced after 1 h incubation with Ap(4)A. Triacylglycerol (TAG) biosynthesis in HepG2 cells was not significantly influenced by Ap(4)A; there was just a tendency for a concentration-dependent decrease in TAG levels. In conclusion Ap(4)A as a diabetogenetic compound is not likely to be responsible for the development of insulin resistance or of hyperlipidemia. Parameters such as free fatty acids, cholesterol and triacylglycerols are not elevated by Ap(4)A, but are even decreased. Ap(4)A seems to be involved in the development of diabetes mellitus by increasing blood glucose and decreasing plasma insulin as shown earlier, but not in diabetes mellitus-associated diseases such as insulin resistance or hyperlipidemia.

Peak flood estimation using gene expression programming

NASA Astrophysics Data System (ADS)

Zorn, Conrad R.; Shamseldin, Asaad Y.

2015-12-01

As a case study for the Auckland Region of New Zealand, this paper investigates the potential use of gene-expression programming (GEP) in predicting specific return period events in comparison to the established and widely used Regional Flood Estimation (RFE) method. Initially calibrated to 14 gauged sites, the GEP derived model was further validated to 10 and 100 year flood events with a relative errors of 29% and 18%, respectively. This is compared to the RFE method providing 48% and 44% errors for the same flood events. While the effectiveness of GEP in predicting specific return period events is made apparent, it is argued that the derived equations should be used in conjunction with those existing methodologies rather than as a replacement.

Multiplicity among chemically peculiar stars. II. Cool magnetic Ap stars

NASA Astrophysics Data System (ADS)

Carrier, F.; North, P.; Udry, S.; Babel, J.

2002-10-01

We present new orbits for sixteen Ap spectroscopic binaries, four of which might in fact be Am stars, and give their orbital elements. Four of them are SB2 systems: HD 5550, HD 22128, HD 56495 and HD 98088. The twelve other stars are: HD 9996, HD 12288, HD 40711, HD 54908, HD 65339, HD 73709, HD 105680, HD 138426, HD 184471, HD 188854, HD 200405 and HD 216533. Rough estimates of the individual masses of the components of HD 65339 (53 Cam) are given, combining our radial velocities with the results of speckle interferometry and with Hipparcos parallaxes. Considering the mass functions of 74 spectroscopic binaries from this work and from the literature, we conclude that the distribution of the mass ratio is the same for cool Ap stars and for normal G dwarfs. Therefore, the only differences between binaries with normal stars and those hosting an Ap star lie in the period distribution: except for the case of HD 200405, all orbital periods are longer than (or equal to) 3 days. A consequence of this peculiar distribution is a deficit of null eccentricities. There is no indication that the secondary has a special nature, like e.g. a white dwarf. Based on observations collected at the Observatoire de Haute-Provence (CNRS), France. Tables 1 to 3 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/394/151 Appendix B is only available in electronic form at http://www.edpsciences.org

78 FR 14577 - Final Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... regulatory floodways on the Flood Insurance Rate Maps (FIRMs) and where applicable, in the supporting Flood Insurance Study (FIS) reports have been made final for the communities listed in the table below. The FIRM... participation in the Federal Emergency Management Agency's (FEMA's) National Flood Insurance Program (NFIP). In...

78 FR 43899 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

..., ``Flood Insurance.'') Dated: July 2, 2013. Roy E. Wright, Deputy Associate Administrator for Mitigation...] Changes in Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final notice. SUMMARY: New or modified Base (1% annual-chance) Flood Elevations (BFEs), base flood depths...

76 FR 12308 - Modernizing the FCC Form 477 Data Program; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Parts 1, 20, and 43 [WCB: WC Docket Nos. 07-38, 09-190, 10-132, 11-10; FCC 11-14] Modernizing the FCC Form 477 Data Program; Correction AGENCY: Federal..., Deputy Manager. [FR Doc. 2011-5095 Filed 3-4-11; 8:45 am] BILLING CODE 6712-01-P ...

78 FR 73504 - Procurement List; Proposed Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

... Logistics Support Detachment, Undisclosed Location*, Ft. Belvoir, VA. NPA: MVLE, Inc., Springfield, VA. Contracting Activity: Directorate of Contracting Procurement Logistics Support Detachment, Fort Belvoir, VA.... Lineback, Director, Business Operations. [FR Doc. 2013-29139 Filed 12-5-13; 8:45 am] BILLING CODE 6353-01-P ...

Peak discharge of a Pleistocene lava-dam outburst flood in Grand Canyon, Arizona, USA

NASA Astrophysics Data System (ADS)

Fenton, Cassandra R.; Webb, Robert H.; Cerling, Thure E.

2006-03-01

The failure of a lava dam 165,000 yr ago produced the largest known flood on the Colorado River in Grand Canyon. The Hyaloclastite Dam was up to 366 m high, and geochemical evidence linked this structure to outburst-flood deposits that occurred for 32 km downstream. Using the Hyaloclastite outburst-flood deposits as paleostage indicators, we used dam-failure and unsteady flow modeling to estimate a peak discharge and flow hydrograph. Failure of the Hyaloclastite Dam released a maximum 11 × 10 9 m 3 of water in 31 h. Peak discharges, estimated from uncertainty in channel geometry, dam height, and hydraulic characteristics, ranged from 2.3 to 5.3 × 10 5 m 3 s -1 for the Hyaloclastite outburst flood. This discharge is an order of magnitude greater than the largest known discharge on the Colorado River (1.4 × 10 4 m 3 s -1) and the largest peak discharge resulting from failure of a constructed dam in the USA (6.5 × 10 4 m 3 s -1). Moreover, the Hyaloclastite outburst flood is the oldest documented Quaternary flood and one of the largest to have occurred in the continental USA. The peak discharge for this flood ranks in the top 30 floods (>10 5 m 3 s -1) known worldwide and in the top ten largest floods in North America.

76 FR 43194 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

... the dates listed in the table below and revise the Flood Insurance Rate Maps (FIRMs) in effect prior... Express-News. Street, Suite 1.20, San Antonio, TX 78205. Brazos City of College May 9, 2011; May 16, The... Unincorporated areas May 9, 2011; May 16, The Honorable Duane September 13, 2011 481195 of Brazos County (10...

New developments at the Flood Forecasting Centre: operational flood risk assessment and guidance

NASA Astrophysics Data System (ADS)

Pilling, Charlie

2017-04-01

The Flood Forecasting Centre (FFC) is a partnership between the UK Met Office, the Environment Agency and Natural Resources Wales. The FFC was established in 2009 to provide an overview of flood risk across England and Wales and to provide flood guidance services primarily for the emergency response community. The FFC provides forecasts for all natural sources of flooding, these being fluvial, surface water, coastal and groundwater. This involves an assessment of possible hydrometeorological events and their impacts over the next five days. During times of heightened flood risk, the close communication between the FFC, the Environment Agency and Natural Resources Wales allows mobilization and deployment of staff and flood defences. Following a number of severe flood events during winters 2013-14 and 2015-16, coupled with a drive from the changing landscape in national incident response, there is a desire to identify flood events at even longer lead time. This earlier assessment and mobilization is becoming increasingly important and high profile within Government. For example, following the exceptional flooding across the north of England in December 2015 the Environment Agency have invested in 40 km of temporary barriers that will be moved around the country to help mitigate against the impacts of large flood events. Efficient and effective use of these barriers depends on identifying the broad regions at risk well in advance of the flood, as well as scaling the magnitude and duration of large events. Partly in response to this, the FFC now produce a flood risk assessment for a month ahead. In addition, since January 2017, the 'new generation' daily flood guidance statement includes an assessment of flood risk for the 6 to 10 day period. Examples of both these new products will be introduced, as will some of the new developments in science and technical capability that underpin these assessments. Examples include improvements to fluvial forecasting from 'fluvial

76 FR 33121 - List of Approved Spent Fuel Storage Casks: HI-STORM Flood/Wind Addition

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... Storage Casks: HI-STORM Flood/Wind Addition AGENCY: Nuclear Regulatory Commission. ACTION: Direct final... regulations to add the Holtec HI-STORM Flood/Wind cask system to the ``List of Approved Spent Fuel Storage... Title 10 of the Code of Federal Regulations Section 72.214 to add the Holtec HI- STORM Flood/Wind cask...

75 FR 74103 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on AP1000...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-30

... Impact Assessment for the proposed AP1000 design. The Subcommittee will hear presentations by and hold... be obtained from the website cited above or by contacting the identified DFO. Moreover, in view of...

76 FR 42143 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-18

... Announcement: [76 FR 41534, July 14, 2011]. STATUS: Open Meeting. PLACE: 100 F Street, NE., Washington, DC...: Cancellation of Meeting. The Open Meeting scheduled for Thursday, July 14, 2011 at 10 a.m. has been cancelled..., 2011. Cathy H. Ahn, Deputy Secretary. [FR Doc. 2011-18051 Filed 7-14-11; 11:15 am] BILLING CODE 8011-01...

78 FR 64186 - Boundary Expansion of Thunder Bay National Marine Sanctuary

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

.... Basta, Director, Office of National Marine Sanctuaries. [FR Doc. 2013-25138 Filed 10-25-13; 8:45 am.... 130403324-3 376-01 RIN 0648-BC94] Boundary Expansion of Thunder Bay National Marine Sanctuary AGENCY: Office... June 14, 2013, NOAA published a proposed rule in the Federal Register to revise the regulations for the...

Effects of environmental estrogenic chemicals on AP1 mediated transcription with estrogen receptors alpha and beta.

PubMed

Fujimoto, Nariaki; Honda, Hiroaki; Kitamura, Shigeyuki

2004-01-01

There has been much discussion concerning endocrine disrupting chemicals suspected of exerting adverse effects in both wildlife and humans. Since the majority of these compounds are estrogenic, a large number of in vitro tests for estrogenic characteristics have been developed for screening purpose. One reliable and widely used method is the reporter gene assay employing estrogen receptors (ERs) and a reporter gene with a cis-acting estrogen responsive element (ERE). Other elements such as AP1 also mediate estrogenic signals and the manner of response could be quite different from that of ERE. Since this has yet to be explored, the ER mediated AP1 activity in response to a series of environmental estrogens was investigated in comparison with ERE findings. All the compounds exhibited estrogenic properties with ERE-luc and their AP1 responses were quite similar. These was one exception, however, p,p'-DDT (1,1,1,-trichloro-2,2-bis(p-chlorophenyl)ethane) did not exert any AP1-luc activity, while it appeared to be estrogenic at 10(-7) to 10(-5)M with the ERE action. None of the compounds demonstrated ER beta:AP1 activity. These data suggest that significant differences can occur in responses through the two estrogen pathways depending on environmental chemicals.

78 FR 5162 - Designation of a Nonessential Experimental Population of Central Valley Spring-Run Chinook Salmon...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

... Director, Office of Protected Resources, National Marine Fisheries Service. [FR Doc. 2013-01343 Filed 1-23.... SUMMARY: On January 16, 2013, we, NMFS, published a proposed rule to designate a nonessential experimental... January 29, 2013, at the Fresno Metropolitan Flood Control District, Board Meeting Room, 5469 E. Olive...

Anthropogenic greenhouse gas contribution to UK autumn flood risk

NASA Astrophysics Data System (ADS)

Pall, Pardeep; Aina, Tolu; Stone, Dáithí; Stott, Peter; Nozawa, Toru; Hilberts, Arno; Lohmann, Dag; Allen, Myles

2010-05-01

Interest in attributing the risk of damaging weather-related events to anthropogenic climate change is increasing[1]. Yet climate models typically used for studying the attribution problem do not resolve weather at scales causing damage[2]. Here we present the first multi-step study that attributes increasing risk of a damaging regional weather-related event to global anthropogenic greenhouse gas emissions. The event was the UK flooding of October and November 2000, occurring during the wettest autumn in England & Wales since records began in 1766[3] and inundating several river catchments[4]. Nearly 10,000 properties were flooded and transport services and power supplies severely disrupted, with insured losses estimated at £1.3bn[5,6]. Though the floods were deemed a ‘wake up call' to the impacts of climate change[7], anthropogenic drivers cannot be blamed for this individual event: but they could be blamed for changing its risk[8,9]. Indeed, typically quoted thermodynamic arguments do suggest increased probability of precipitation extremes under anthropogenic warming[10]. But these arguments are too simple[11,12,13] to fully account for the complex weather[4,14] associated with the flooding. Instead we use a Probabilistic Event Attribution framework, to rigorously estimate the contribution of anthropogenic greenhouse gas emissions to England & Wales Autumn 2000 flood risk. This involves comparing an unprecedented number of daily river runoff realisations for the region, under Autumn 2000 scenarios both with and without the emissions. These realisations are produced using publicly volunteered distributed computing power to generate several thousand seasonal forecast resolution climate model simulations[15,16] that are then fed into a precipitation-runoff model[17,18]. Autumn 2000 flooding is characterised by realisations exceeding the highest daily river runoff for that period, derived from the observational-based ERA-40 re-anaylsis[19]. We find that our

10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Design Certification Rule for the AP600 Design C Appendix C to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Pt. 52, App. C Appendix C to Part 52—Design Certification Rule for the...

Analogs of diadenosine tetraphosphate (Ap4A).

PubMed

Guranowski, Andrzej

2003-01-01

This review summarizes our knowledge of analogs and derivatives of diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A), the most extensively studied member of the dinucleoside 5',5"'-P1,Pn-polyphosphate (NpnN) family. After a short discussion of enzymes that may be responsible for the accumulation and degradation of Np4)N's in the cell, this review focuses on chemically and/or enzymatically produced analogs and their practical applications. Particular attention is paid to compounds that have aided the study of enzymes involved in the metabolism of Ap4A (Np4N'). Certain Ap4A analogs were alternative substrates of Ap4A-degrading enzymes and/or acted as enzyme inhibitors, some other helped to establish enzyme mechanisms, increased the sensitivity of certain enzyme assays or produced stable enzyme:ligand complexes for structural analysis.

75 FR 42830 - Proposed Collection; Comment Request for Regulation 112841-10

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... an existing proposed regulation, REG-112841-10, Indoor Tanning Services; Cosmetic Services; Excise... through the Internet, at [email protected] . SUPPLEMENTARY INFORMATION: Title: Indoor Tanning... (124 Stat. 119 (2010)) to impose an excise tax on indoor tanning services. This information is required...

A Framework for Flood Risk Analysis and Benefit Assessment of Flood Control Measures in Urban Areas