Convergence and Religious Terrorism in America

DTIC Science & Technology

2004-09-01

William Miller, 18 progenitor of today’s Seventh Day Adventist Church, and Joseph Smith, the founder of the Mormon Church. Despite the apparent...situation as we analyze the formation of present- day cults and sects that diverge from the social norm. We take note, too, of the fact that growth...Bartholomew’s Day Massacre of French Protestants; mass arrests and executions of Protestants across Europe; and persecutions and executions by

Contribution of the ethics committee of the French society of intensive care medicine to a scenario for the implementation of organ donation after Maastricht III-type cardiac death in France.

PubMed

Graftieaux, J-P; Bollaert, P-E; Haddad, L; Kentish-Barnes, N; Nitenberg, G; Robert, R; Villers, D; Dreyfuss, D

2014-02-01

French law allows organ donation after death due to cardiocirculatory arrest. In the Maastricht classification, type III non-heart-beating donors are those who experience cardiocirculatory arrest after the withdrawal of life-sustaining treatments. French authorities in charge of regulating organ donation (Agence de la Biomédecine, ABM) are considering organ collection from Maastricht type III donors. We describe a scenario for Maastricht type III organ donation that fully complies with the ethical norms governing care to dying patients. That organ donation may occur after death should have no impact on the care given to the patient and family. The dead-donor rule must be followed scrupulously: the organ retrieval procedure must neither cause nor hasten death. The decision to withdraw life-sustaining treatments, withdrawal modalities, and care provided to the patient and family must adhere strictly to the requirements set forth in patient-rights legislation (the 2005 Léonetti law in France) and should not be influenced in any way by the possibility of organ donation. A major ethical issue regarding the family is how best to transition from discussing treatment-withdrawal decisions to discussing possible organ retrieval for donation should the patient die rapidly after treatment withdrawal. Close cooperation between the healthcare team and the organ retrieval team is crucial to minimize the distress of family members during this transition. Modalities for implementing Maastricht type III organ donation are discussed here, including the best location for withdrawing life-sustaining treatments (operating room or intensive care unit). Copyright © 2014. Published by Elsevier SAS.

Gathering the forgotten voices: An oral history of the Canada-France-Hawaii Telescope's early years

NASA Astrophysics Data System (ADS)

Laychak, M. B.; Bryson, L.

2008-06-01

They came to the Big Island from as far away as Murrumbeena, Australia, and as near by as Hilo, Hawaii. They were the progeny of Scottish coal miners, French physicists, Chicago truck drivers, Japanese samurai and Big Island cane workers. Together, these men and women would build and commission one of the most dynamic and productive 3.6-m telescopes in the world and one that remains at the forefront of science and technology. The CFHT oral history DVD preserves the stories of the first decade and a half of the observatory.

BOOK REVIEW: Great Physicists - The Life and Times of Leading Physicists from Galileo to Hawking

NASA Astrophysics Data System (ADS)

Cropper, William H.

2002-11-01

The author, a former American chemistry professor, has organized his book into nine parts with 29 chapters, covering, in a fairly historical sequence and systemtic conceptual progression, all fundamentals of today's physics: i.e., mechanics, thermodynamics, electromagnetism, statistical mechanics, relativity, quantum mechanics, nuclear physics, particle physics, astronomy-astrophysics-cosmology. Obviously, the 20th century (when about 90% of professional physicists of all time worked) assumes with five topics the dominant role in this enterprise. For each topic, a small number (ranging from one to eight) of leading personalities is selected and the biographies of these 29 physicists, including two women (Marie Curie and Lise Meitner), are presented in some detail together with their achievements in the particular topic. Important relevant contributions of other scholars to each topic are also discussed. In addition, Cropper provides each of the topics with a short 'historical synopsis' justifying his selection of key persons. One may argue that concentrating on leading physicists constitutes an old-fashioned approach to displaying the history and contents of fundamental topics in physics. However, the mixture of biographies and explanation of leading contributions given here will certainly serve for a larger public, not just professional physicists and scientists, as a guide through the exciting development of physical ideas and discoveries. In general, the presentation of the material is quite satisfactory (with only few slips, e.g., in the Meitner story, where the author follows too closely a new biography) and gives the essence of the great advances in physics since the 15th century. One notices perhaps the limitation of the author in cases where no biography in English is available - this would also explain the omission of some of the main contributors to atomic and particle physics, such as Arnold Sommerfeld and Hideki Yukawa, or that French or Russian readers might occasionally miss a proper mention of their scientific heroes. These slightly critical observations should not obscure the impression that the chemist Cropper has succeeded with his goal of writing a very useful and informative book, displaying great understanding of the life of the physicists, their ingenious theoretical ideas and experimental discoveries. Simultaneously he has provided a pleasantly readable account of the great success story of physics extending over the past three hundred years. Both laymen and professionals may like to have the book in their public or private libraries. Helmut Rechenberg

The life and achievements of Erwin-Félix Lewy-Bertaut (1913-2003)

NASA Astrophysics Data System (ADS)

Férey, Gérard; Hodeau, Jean-Louis

2015-02-01

Erwin-Félix Lewy-Bertaut was initially a lawyer. He left Germany for France when the Nazis rose to power, having been born into a German Jewish family. He became a French citizen in 1936 and embarked upon a scientific career, first in organic chemistry in Bordeaux. The troubles associated with World War II obliged him to move to Grenoble under the protection of Louis Néel. In addition to his creative activity in the new field of inorganic solid state chemistry, he rapidly became a crystallographer and a physicist of magnetism, noted for his impressive activity in both of these domains. He became a pioneer of neutron diffraction and was pivotal to the creation of the Institut Laue-Langevin. Owing to the impact of his work, he was involved in the key international organizations responsible for shaping crystallography and physics. A member of the French Academy of Sciences, Monsieur Bertaut received many international awards. He was a very kind man of culture.

Laborious and perilous adventures: the triumphant return of Francois Arago to France

NASA Astrophysics Data System (ADS)

Murdin, P.

2005-08-01

As a young man, while measuring the Paris Meridian in the Balearic Islands, the French astronomer Francois Arago was caught up in events of the Peninsular and Napoleonic Wars and found himself under arrest in Algiers. Released from custody and returning from Algiers to Marseille in 1809, he was detained again, this time by the British Royal Navy warship HMS Minstrel, but let go. The Algerian ships with which he was traveling were captured and taken to Gibraltar. The incident caused an abrupt deterioration in Anglo-Algerian relations, which however recovered when Napoleon declared war on Algiers. A comparison of the account in his autobiography with the logs of Royal Navy ships confirms the outline and many details of his account of his arrest but also sheds light on the reliability of his autobiography.

Effect of tidal overwash on the embryonic development of leatherback turtles in French Guiana.

PubMed

Caut, Stéphane; Guirlet, Elodie; Girondot, Marc

2010-05-01

In marine turtles, the physical conditions experienced by eggs during incubation affect embryonic development. In the leatherback, hatching success is known to be low in relation to other marine turtles as a result of high embryonic mortality. Moreover, the hatching success on Yalimapo in French Guiana, one major nesting beach for this species, is lower compared to other nesting sites. We assessed the rate of leatherback turtle embryonic mortality in order to investigate the tolerance of leatherback turtle clutches laid on Yalimapo beach to tidal overwash, and we highlight causes of poor hatching success. Of the 89 nests studied, 27 were overlapped by tide at least once during the incubation period (of which five nests were lost by erosion). The hatching success was on average significantly lower in overwashed nests than in non-overwashed, highlighting the existence of embryonic developmental arrest linked to tidal inundation. The stages of developmental arrest and their proportion are linked with time, frequency and level of overwash events. In the context of global warming and associated sea-level rise, understanding the detrimental effect of tidal inundation on the development of marine turtle nests is of interest in nesting sites where turtles are likely to be forced to nest closer to the tide line, thus exposing their nests to greater risk of nest overlap with sea and tidal inundation. Copyright 2009 Elsevier Ltd. All rights reserved.

Francis Perrin's 1939 Analysis of Uranium Criticality

NASA Astrophysics Data System (ADS)

Reed, Cameron

2012-03-01

In May 1939, French physicist Francis Perrin published the first numerical estimate of the fast-neutron critical mass of a uranium compound. While his estimate of about 40 metric tons (12 tons if tamped) pertained to uranium oxide of natural isotopic composition as opposed to the enriched uranium that would be required for a nuclear weapon, it is interesting to examine Perrin's physics and to explore the subsequent impact of his paper. In this presentation I will discuss Perrin's model, the likely provenance of his parameter values, and how his work compared to the approach taken by Robert Serber in his 1943 Los Alamos Primer.

Angels and Demons: The Science Behind the Scenes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graf, Norman

Does antimatter really exist? How and why do scientists produce and use it? Does CERN exist and is there an underground complex deep beneath the Swiss/French border? Is truth stranger than fiction? Find out at the coming public lecture. On Tuesday, May 12, SLAC physicist Norman Graf will discuss the real science behind Angels & Demons, Dan Brown's blockbuster novel and the basis of an upcoming Tom Hanks movie. Graf's' talk is one in a series of public lectures across the U.S., Canada and Puerto Rico to share the science of antimatter and the Large Hadron Collider, and the excitementmore » of particle physics research.« less

Signing off

NASA Astrophysics Data System (ADS)

2001-11-01

How much do we value our physicists? Some banknotes carry pictures of great physicists. It seems obvious to conduct an investigation using this data to find out how much we value them. Research can be carried out by finding what denomination a country uses for its physicists and using some simple currency conversions. All discussions of the relative merits of physicists have so far ignored this data. Newton, so often the baseline of physics greatness, was once represented on the English one-pound note. Although he has since been shredded and replaced by coins we will use the Newton as our base unit of currency, where one Newton is equal to one pound [those making a dimensional analysis should remember we are talking about currency]. The Danes value Bohr at 42 Newtons, whilst the Austrians consider Schrödinger to be worth 46 Newtons At this point the research becomes interesting because an (only slightly varying) constant emerges. The Danes value Bohr at 42 Newtons, whilst the Austrians consider Schrödinger to be worth 46 Newtons. Obviously, as with all quantum physics effects, those spending Schrödingers (as well as anyone who has retired) will find that when you have money to spend there is not time, and when you have the time there is no money to spend. These figures clearly show a trend that all physicists trade at about 45 Newtons. And they also seem to show how much the UK has undervalued Newton. However, this result may well be a feature of a newly suggested inverse square law of being famous, that the longer ago you lived the less important you seem. Physicists are working hard to reconcile this with the 'never famous before you are dead' postulate. More data is needed. With Marie Curie on the 500 French Franc note, one Curie is worth 48 Newtons, supporting the theory. However, Pierre Curie also appeared on this note so Marie can only really be valued at 24 Newtons. Quite how two physicists superpose in their currency valuations is unknown by theorists. Appearing on two notes also raises questions about the effect on value of working in several countries. The idea is yet to be fully formulated, but it would be nice if it were exponential. Certainly the fact that New Zealand's hero Rutherford has been represented on the one hundred dollar note, valuing him at 28 Newtons, adds to the idea of an attenuation coefficient. There also seem to be transient effects on value, resulting from the personality of the physicist involved. It seems entirely appropriate that the mercurial Tesla should be represented by the ten billion dollar Yugoslavian note, which was nevertheless worth almost nothing. But of course any discussions of great physicists always involve Einstein. Amazingly he has been seen represented on the Israeli five-pound note, valuing him at about 0.08 Newtons. Before rushing off, in support of the great man, to prove that this is clearly a relativistic aberration, just pause. Perhaps calculating your salary in Einsteins could be really rather good for morale... More about physicists on money can be found at www2.physics.umd.edu/~redish/Money/ Philip Britton Head of Physics, Leeds Grammar School, UK

Amygdalin, from Apricot Kernels, Induces Apoptosis and Causes Cell Cycle Arrest in Cancer Cells: An Updated Review.

PubMed

Saleem, Mohammad; Asif, Jawaria; Asif, Muhammad; Saleem, Uzma

2018-01-05

Amygdalin is a cyanogenic glycoside which is described as a naturally occurring anti-cancer agent. In 1830s, French chemists Robiquet and Boutron-Charlard isolated amygdalin from bitter almonds. Apoptosis is an important mechanism in cancer treatment by amygdalin. Amygdalin can probably stimulate apoptotic process in cancerous cells by increasing activity of Bax (pro-apoptotic protein) and caspase-3 and decreasing expression of Bcl-2 (anti-apoptotic protein). Amygdalin promotes arrest of cell cycle in G0/G1 phase followed by decreasing number of S and G2/M phase cells. So, amygdalin enhances deceleration of cell cycle by blocking cell proliferation and growth. The current review highlights that amygdalin has potential to be used as an anticancer agent in cancer therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Arkady Benediktovich Migdal

NASA Astrophysics Data System (ADS)

Agasyan, N. O.; Belyayev, S. T.; Okun, L. B.; Sapershtein, E. E.

2013-06-01

The outstanding theoretical physicist Arkady Benediktovich Migdal was one of the pioneers of theoretical nuclear physics in the Soviet Union, the founder of a major scientific school, a man of diverse gifts and irresistible personal charm. A. B. Migdal was born on March 11, 1911, in Lida (Belarus). In the 1920s his family moved to Leningrad. Migdal produced his first scientific work at age 17. He then enrolled at the physics department of the Leningrad State University (LSU), but studied there only a short while: arrested, he spent over two months under investigation, then was released (releases were still granted sometimes then). From 1931 to 1936, while working at the factory "Electrical Appliance," he produced several scientific works. At this time he managed to recover a place at the LSU extension division. After graduation in 1936 A. B. Migdal enrolled in graduate school at the Leningrad Physical-Technical Institute, where he formed his research interests and his own research style. His thesis adviser was M. P. Bronshtein. [Note: See footnote, p. 171.] Despite the briefness of this contact with Bronshtein - in 1937 Matvei Petrovich was arrested and executed - this bright, talented and deep person played a major role in Migdal's scientific development...

CERN - Six Decades of Science, Innovation, Cooperation, and Inspiration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quigg, Chris

The European Laboratory for Particle Physics, which straddles the Swiss-French border northwest of Geneva, celebrates its sixtieth birthday in 2014 CERN is the preeminent particle-physics institution in the world, currently emphasizing the study of collisions of protons and heavy nuclei at very high energies and the exploration of physics on the electroweak scale (energies where electromagnetism and the weak nuclear force merge). With brilliant accomplishments in research, innovation, and education, and a sustained history of cooperation among people from different countries and cultures, CERN ranks as one of the signal achievements of the postwar European Project. For physicists the worldmore » over, the laboratory is a source of pride and inspiration.« less

Etiological diagnoses of out-of-hospital cardiac arrest survivors admitted to the intensive care unit: Insights from a French registry.

PubMed

Geri, Guillaume; Passouant, Olivier; Dumas, Florence; Bougouin, Wulfran; Champigneulle, Benoit; Arnaout, Michel; Chelly, Jonathan; Chiche, Jean-Daniel; Varenne, Olivier; Guillemet, Lucie; Pène, Frederic; Waldmann, Victor; Mira, Jean-Paul; Marijon, Eloi; Cariou, Alain

2017-08-01

Respective proportions of final etiologies are disparate in cohorts of cardiac arrest patients, depending on examined population and diagnostic algorithms. In particular, prevalence and characteristics of sudden unexplained death syndrome (SUDS) are debated. We aimed at describing etiologies in a large cohort of aborted out-of-hospital cardiac arrest (OHCA) patients, in order to assess prevalence and outcome of SUDS. We analyzed data from our prospective registry of successfully resuscitated OHCA patients admitted to a cardiac arrest centre between January 2002 and December 2014. The in-ICU diagnostic strategy included early coronary angiogram, brain and chest CT scan. This was completed by an extensive diagnostic strategy, encompassing biological and toxicological tests, repeated electrocardiograms and echocardiography, MRI and pharmacologic tests. Two independent investigators reviewed each final diagnosis. Baseline characteristics were compared between subgroups of patients. Three-month mortality was compared between subgroups using univariate Kaplan-Meier curves. Over the study period, 1657 patients were admitted to our unit after an aborted OHCA. The event was attributed to a non-cardiac and a cardiac cause in 478 (32.0%) and 978 (65.5%) patients, respectively. The main cause of cardiac related OHCA was ischemic heart disease (76.7%) while primary electrical diseases accounted for only 2.5%. Sudden unexplained deaths (SUDS) were observed in 37 (2.5%) patients. We observed that ischemic heart disease was by far the most common cause of cardiac arrest, while primary electrical diseases were much less frequent. SUDS accounted for a very small proportion of patients who suffered an aborted OHCA. Copyright © 2017 Elsevier B.V. All rights reserved.

Should We Perform an Immediate Coronary Angiogram in All Patients After Cardiac Arrest?: Insights From a Large French Registry.

PubMed

Bougouin, Wulfran; Dumas, Florence; Karam, Nicole; Maupain, Carole; Marijon, Eloi; Lamhaut, Lionel; Jost, Daniel; Geri, Guillaume; Beganton, Frankie; Varenne, Olivier; Spaulding, Christian; Jouven, Xavier; Cariou, Alain

2018-02-12

This study sought to assess the relationship between an immediate invasive strategy and survival after an out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause, according to prognosis evaluated on hospital arrival. An immediate coronary angiogram (CAG) may be associated with better outcome after OHCA in neurologically preserved patients but could be futile in other cases. From May 2011 to May 2015, we collected data for all patients admitted in hospital after OHCA in Paris and its suburbs (France). Risk of in-hospital death was retrospectively calculated using the validated Cardiac Arrest Hospital Prognosis score, which includes age, setting, initial rhythm, durations from collapse to basic life support and from basic life support to return of spontaneous circulation, pH, and epinephrine dose. Independent predictors of survival at discharge (including immediate CAG) were assessed in multivariate logistic regression in each of the 3 pre-defined subgroups of Cardiac Arrest Hospital Prognosis score: low risk (<150 points), medium risk (150 to 200 points), and high risk (>200 points) for in-hospital death. A total of 1,410 patients were included and overall survival rate at hospital discharge was 32%. Distribution in the low-, medium-, and high-risk Cardiac Arrest Hospital Prognosis subgroups was 667 (47%), 469 (33%), and 274 patients (20%), respectively. The rate of early CAG was 86%, 66%, and 47% in the low-, medium-, and high-risk subgroups, respectively (p < 0.001). Early invasive strategy was independently associated with better survival in low-risk patients (odds ratio: 2.3; 95% confidence interval: 1.4 to 3.9; p = 0.001), but not in medium-risk (p = 0.55) and high-risk (p = 0.43) patients. Sensitivity analysis found consistent results. In cardiac arrest patients, our results suggest that investigations regarding early CAG after OHCA should focus on patients with preserved neurological status. Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Targeted temperature management in the ICU: guidelines from a French expert panel.

PubMed

Cariou, Alain; Payen, Jean-François; Asehnoune, Karim; Audibert, Gerard; Botte, Astrid; Brissaud, Olivier; Debaty, Guillaume; Deltour, Sandrine; Deye, Nicolas; Engrand, Nicolas; Francony, Gilles; Legriel, Stéphane; Levy, Bruno; Meyer, Philippe; Orban, Jean-Christophe; Renolleau, Sylvain; Vigue, Bernard; De Saint Blanquat, Laure; Mathien, Cyrille; Velly, Lionel

2017-12-01

Over the recent period, the use of induced hypothermia has gained an increasing interest for critically ill patients, in particular in brain-injured patients. The term "targeted temperature management" (TTM) has now emerged as the most appropriate when referring to interventions used to reach and maintain a specific level temperature for each individual. TTM may be used to prevent fever, to maintain normothermia, or to lower core temperature. This treatment is widely used in intensive care units, mostly as a primary neuroprotective method. Indications are, however, associated with variable levels of evidence based on inhomogeneous or even contradictory literature. Our aim was to conduct a systematic analysis of the published data in order to provide guidelines. We present herein recommendations for the use of TTM in adult and paediatric critically ill patients developed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. These guidelines were conducted by a group of experts from the French Intensive Care Society (Société de Réanimation de Langue Française [SRLF]) and the French Society of Anesthesia and Intensive Care Medicine (Société Francaise d'Anesthésie Réanimation [SFAR]) with the participation of the French Emergency Medicine Association (Société Française de Médecine d'Urgence [SFMU]), the French Group for Pediatric Intensive Care and Emergencies (Groupe Francophone de Réanimation et Urgences Pédiatriques [GFRUP]), the French National Association of Neuro-Anesthesiology and Critical Care (Association Nationale de Neuro-Anesthésie Réanimation Française [ANARLF]), and the French Neurovascular Society (Société Française Neurovasculaire [SFNV]). Fifteen experts and two coordinators agreed to consider questions concerning TTM and its practical implementation in five clinical situations: cardiac arrest, traumatic brain injury, stroke, other brain injuries, and shock. This resulted in 30 recommendations: 3 recommendations were strong (Grade 1), 13 were weak (Grade 2), and 14 were experts' opinions. After two rounds of rating and various amendments, a strong agreement from voting participants was obtained for all 30 (100%) recommendations, which are exposed in the present article.

Mutations in SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome.

PubMed

Bellanné-Chantelot, Christine; Schmaltz-Panneau, Barbara; Marty, Caroline; Fenneteau, Odile; Callebaut, Isabelle; Clauin, Séverine; Docet, Aurélie; Damaj, Gandhi-Laurent; Leblanc, Thierry; Pellier, Isabelle; Stoven, Cécile; Souquere, Sylvie; Antony-Debré, Iléana; Beaupain, Blandine; Aladjidi, Nathalie; Barlogis, Vincent; Bauduer, Frédéric; Bensaid, Philippe; Boespflug-Tanguy, Odile; Berger, Claire; Bertrand, Yves; Carausu, Liana; Fieschi, Claire; Galambrun, Claire; Schmidt, Aline; Journel, Hubert; Mazingue, Françoise; Nelken, Brigitte; Quah, Thuan Chong; Oksenhendler, Eric; Ouachée, Marie; Pasquet, Marlène; Saada, Véronique; Suarez, Felipe; Pierron, Gérard; Vainchenker, William; Plo, Isabelle; Donadieu, Jean

2018-06-18

Congenital neutropenias (CN) are rare heterogeneous genetic disorders with about 25% of patients without known genetic defects. Using whole-exome sequencing, we identified a heterozygous mutation in the SRP54 gene, encoding the signal recognition particle (SRP) 54 GTPase protein, in 3 sporadic cases and one autosomal dominant family. We subsequently sequenced the SRP54 gene in 66 probands from the French CN registry. In total, we identified 23 mutated cases (16 sporadic, 7 familial) with seven distinct germline SRP54 mutations including a recurrent in-frame deletion (Thr117del) in 14 cases. In nearly all patients, neutropenia was chronic and profound with promyelocytic maturation arrest, occurring within the first months of life and required long-term G-CSF therapy with a poor response. Neutropenia was sometimes associated with a severe neurodevelopmental delay (n=5) and/or an exocrine pancreatic insufficiency requiring enzyme supplementation (n=3) The SRP54 protein is a key component of the ribonucleoprotein complex that mediates the co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). We showed that SRP54 was specifically upregulated during the in vitro granulocytic differentiation and that SRP54 mutations or knockdown led to a drastically reduced proliferation of granulocytic cells associated with an enhanced P53-dependent apoptosis. Bone marrow examination of SRP54 -mutated patients revealed a major dysgranulopoiesis and features of cellular ER stress and autophagy that were confirmed using SRP54 -mutated primary cells and SRP54 knockdown cells. In conclusion, we characterized a pathological pathway, which represents the second most common cause of CN with maturation arrest in the French CN registry. Copyright © 2018 American Society of Hematology.

Clinical outcomes according to symptom presentation in patients with acute myocardial infarction: Results from the FAST-MI 2010 registry.

PubMed

Puymirat, Etienne; Aissaoui, Nadia; Bonello, Laurent; Cayla, Guillaume; Labèque, Jean-Noel; Nallet, Olivier; Motreff, Pascal; Varenne, Olivier; Schiele, François; Ferrières, Jean; Simon, Tabassome; Danchin, Nicolas

2017-12-01

Atypical clinical presentation in acute myocardial infarction (AMI) patients is not uncommon; most studies suggest that it is associated with unfavorable prognosis. Long-term clinical impact differs according to predominant symptom presentation (typical chest pain, atypical chest pain, syncope, cardiac arrest, or dyspnea) in AMI patients. FAST-MI 2010, a nationwide French registry, included 4169 patients with AMI in 213 centers at the end of 2010 (76% of active centers). Demographics, medical history, hospital management, and outcomes were compared according to predominant symptom presentation. Typical chest pain with no other symptom was reported in 3020 patients (68% in STEMI patients, 76% in NSTEMI patients). Atypical chest pain, dyspnea, syncope, and cardiac arrest were reported in 11%, 11%, 5%, and 1%, respectively. Patients with atypical clinical presentation had a higher cardiovascular risk profile and received fewer medications and a less invasive strategy. Using Cox multivariate analysis, atypical chest pain was not associated with higher death rate at 3 years (HR: 0.96, 95% CI: 0.69-1.33, P = 0.78), whereas cardiac arrest (HR: 2.44, 95% CI: 1.00-5.97, P = 0.05), syncope (HR: 1.70, 95% CI: 1.18-2.46, P = 0.005), and dyspnea (HR: 1.66, 95% CI: 1.31-2.10, P < 0.001) were associated with higher long-term mortality compared with patients with typical isolated chest pain. Similar trends were observed in STEMI and NSTEMI populations. Atypical clinical presentation is observed in about 20% of AMI patients. Cardiac arrest, dyspnea, and syncope represent independent predictors of long-term mortality in STEMI and NSTEMI populations. © 2017 Wiley Periodicals, Inc.

Biological effects and equivalent doses in radiotherapy: A software solution

PubMed Central

Voyant, Cyril; Julian, Daniel; Roustit, Rudy; Biffi, Katia; Lantieri, Céline

2013-01-01

Background The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding delivered doses or any future prescriptions relating to treatment changes. Aim We, therefore, propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). Materials and methods The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. Results and conclusions The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to an equivalent dose computed using standard calculators in seven French radiotherapy centers. PMID:24936319

Medical Physicists and Health Physicists: Radiation Occupations

ERIC Educational Resources Information Center

LaPointe, Jeffrey

2011-01-01

Physics is the study of matter and energy and the ways in which the two interact. Some physicists use their expertise in physics to focus on radiation. These specialists, called medical physicists and health physicists, work to help people or protect the environment. Medical physicists work with physicians, assisting patients who need imaging…

Closed-chest cardiopulmonary bypass and cardioplegia: basis for less invasive cardiac surgery.

PubMed

Peters, W S; Siegel, L C; Stevens, J H; St Goar, F G; Pompili, M F; Burdon, T A

1997-06-01

We developed a method of closed-chest cardiopulmonary bypass to arrest and protect the heart with cardioplegic solution. This method was used in 54 dogs and the results were retrospectively analyzed. Bypass cannulas were placed in the right femoral vessels. A balloon occlusion catheter was passed via the left femoral artery and positioned in the ascending aorta. A pulmonary artery vent was placed via the jugular vein. In 17 of the dogs retrograde cardioplegia was provided with a percutaneous coronary sinus catheter. Cardiopulmonary bypass time was 111 +/- 27 minutes (mean +/- standard deviation) and cardiac arrest time was 66 +/- 21 minutes. Preoperative cardiac outputs were 2.9 +/- 0.70 L/min and postoperative outputs were 2.9 +/- 0.65 L/min (p = not significant). Twenty-one-French and 23F femoral arterial cannulas that allowed coaxial placement of the ascending aortic balloon catheter were tested in 3 male calves. Line pressures were higher, but not clinically limiting, with the balloon catheter placed coaxially. Adequate cardiopulmonary bypass and cardioplegia can be achieved in the dog without opening the chest, facilitating less invasive cardiac operations. A human clinical trial is in progress.

Conducted electrical weapons or stun guns: a review of 46 cases examined in casualty.

PubMed

Becour, Bertrand

2013-06-01

Low-lethality weapons are intended to neutralize a person with maximum security and with minimal risk of injury or death to the user of the weapon, the person arrested, and the witnesses. Under the same circumstances, the use of a firearm is causing mortality of 50%. Marketed since 1974, the Taser X26 is currently staffing services in the French police and gendarmerie. The Taser device has 3 damaging mechanisms: the direct effect of electric current on the tissues, the conversion of electrical energy into thermal energy, and the injuries caused by the general muscle contraction and resulting fall. The study aimed to analyze the specificities of the conducted electrical weapon-related injuries treated in a emergency department on a series of 46 cases. The study population was predominantly middle-aged men. The circumstances of use of the Taser X26 were most often related to an arrest. The frequency of consultation after a shot by Taser X26 was stable. The management is essentially an outpatient because of frequent and benign lesions. The impacts of electrical impulse mainly affect the chest and abdomen. This distribution of impact zones is inhomogeneous, depending on the circumstances of use.

[Cardiac arrest during anesthesia and recovery period].

PubMed

Otteni, J C; Steib, A; Pottecher, T

1990-01-01

Cardiac arrests (CA) occurring during anaesthesia and recovery can be classified into three groups: CA not related to anaesthesia (NACA), CA related to anaesthesia (ACA), whether partially (PACA) or totally (TACA). In the French survey, NACAs were three times more frequent than ACAs. Nearly 25% of ACAs occurred at induction and consisted mainly in TACAs. Another quarter of ACAs occurred during maintenance and consisted mainly in PACAs. About 50% of ACAs occurred after the end of anaesthesia and had the highest mortality rate. Cardiac arrest corresponds to the status of a heart unable to generate the minimum aortic blood flow required for functioning of vital organs. For the brain, a zero-blood flow of more than 4 seconds results in coma. Consequently CA exists when the time interval between two subsequent efficient systoles is greater than 4 seconds. Anaesthetic agents can result in CA by 1) overdose (absolute, relative), 2) anaphylactoid/anaphylactic reactions, 3) specific effects (acetylcholine-like effect, hyperkalaemia and malignant hyperthermia for succinylcholine; vagal effect of vecuronium and atracurium; cardiotoxicity of bupivacaine) and 4) drug interaction. In hypoxic CA, severe neurologic impairment often still exists at the time of onset of CA. The anaesthesia machine and controlled ventilation can induce CA by hypoxic ventilation, overdose of anaesthetic vapour, excessive CO2 reinhalation, hypoventilation, disconnection, excessive pressure in airways. Cardiac hypothermia can be a cause of CA as well as a cause of unsuccessful CPR. Massive infusion of unwarmed fluids and IPPV with unheated gases generate a temperature gradient within the heart which may result in severe arrhythmias and CA.(ABSTRACT TRUNCATED AT 250 WORDS)

Status and Future Manpower Needs of Physicists in Medicine in the United States.

ERIC Educational Resources Information Center

Food and Drug Administration (DHEW), Rockville, MD. Bureau of Radiological Health.

This study describes the duties and responsibilities of the medical physicist and estimates the number of medical physicists needed in the next decade. A questionnaire, sent to members of the American Association of Physicists in Medicine, was designed to cover: characteristics of medical physicists, nature of work in medical physics, distribution…

Eurekas and Euphorias - The Oxford Book of Scientific Anecdotes

NASA Astrophysics Data System (ADS)

Gratzer, Walter

2002-11-01

The march of science has been marked through the years by episodes of drama and comedy, of failure as well as triumph, by outrageous strokes of luck, deserved and undeserved, and sometimes by human tragedy. In Eurekas and Euphorias , Walter Gratzer captures the human face of discovery as he relates many intriguing tales of scientific adventures spanning over two thousand years. Open this book at random and you may chance on the clumsy chemist named Sapper who broke a thermometer in a reaction vat and made the discovery that launched the modern dyestuff industry. Or the physicist who dissolved his gold Nobel Prize medal in acid to prevent it from falling into the hands of the Nazis. The book uncovers deep intellectual friendships, as well as ferocious animosities, and even acts of theft and malice, deceit, and a hoax or two. Indeed, we discover that scientists come in all shapes--the obsessive and the dilettantish, the genial, the envious, the preternaturally brilliant and the slow-witted who sometimes saw further in the end, the open-minded and the intolerant, recluses and arrivistes . We meet mathematicians and physicists in prison cells, and even in a madhouse, making important advances in their field. And we witness the careers, sometimes tragic, sometimes carefree, of the great women scientists, from Hypatia of Alexandria, to Sophie Germain and Sonia Kovalevskaya, to Marie Curie and her relentless battle with the French Academy. Told with wit and relish, here then is a glorious parade to delight the reader, with stories to astonish, to instruct, and most especially, to entertain.

[Training of medical physicists in radiation therapy at the International Educational Center of the Association of Medical Physicists in Russia].

PubMed

Kostylev, V A; Lysenko, M N; Zhgutov, A V; Ulanov, D V; Kislyakova, M V; Kazantsev, P V; Kostylev, D V; Narkevich, B Y

2015-01-01

The efficiency of radiotherapy treatment for cancer patients and use of the state-of-the-art accelerator facilities, in the first place, depends on the qualification and number of medical physicists. The need for the training and continuing professional development (CPD) of medical radiation physicists in Russia and CIS countries has dramatically increased today. The article considers the system of refresher training which should provide the continuing professional development and advance training of medical radiation physicists. The authors analyze the experience of the International Educational Center of the Association of Medical Physicists in Russia involved in the CPD of medical physicists under the IAEA TC projects, RMAPO and N.N. Blokhin RCRC joint educational programs.

Age discrimination in out-of-hospital cardiac arrest care: a case-control study.

PubMed

Wiel, Eric; Di Pompéo, Christophe; Segal, Nicolas; Luc, Gérald; Marc, Jean-Baptiste; Vanderstraeten, Carine; El Khoury, Carlos; Escutnaire, Joséphine; Tazarourte, Karim; Gueugniaud, Pierre-Yves; Hubert, Hervé

2017-12-01

Although some studies have questioned whether cardiopulmonary resuscitation (CPR) in older people could be futile, age is not considered an essential out-of-hospital cardiac arrest (OHCA) prognostic factor. However, in the daily clinical practice of mobile medical teams (MMTs), age seems to be an important factor affecting OHCA care. The purpose of this study was to compare OHCA care and outcomes between young patients (<65 years old) and older patients. We performed a case-control study based on data extracted from the French National Cardiac Arrest (CA) registry. All adult patients with CA recorded between July 2011 and May 2014 were included. Each older patient was matched on three criteria: sex, initial cardiac rhythm and no-flow duration. We studied 4347 pairs. We found significantly less basic life support initiation, shorter advanced cardiac life support duration, less MMT automated chest compression, less MMT ventilation and less MMT epinephrine injection in the older patients. Significant differences were also observed for return of spontaneous circulation (odds ratio (OR)=0.84, 95% confidence interval (CI) 0.77-0.92, p<0.001), transport to hospital (OR=0.58, 95% CI 0.51-0.61, p<0.001), vital status at hospital admission (OR=0.55, 95% CI 0.50-0.60, p<0.001) and vital status 30 days after CA (OR=0.42, 95% CI 0.35-0.50, p<0.001). All OHCA guidelines, ethical statements and clinical procedures do not propose age as a discrimination criterion in OHCA care. However, in our case-control study, we notice a shorter duration and less intensive care among older patients. This finding may partly explain the lower survival rate compared with younger people.

An innovative pedagogic course combining video and simulation to teach medical students about pediatric cardiopulmonary arrest: a prospective controlled study.

PubMed

Drummond, David; Arnaud, Cécile; Thouvenin, Guillaume; Guedj, Romain; Grimprel, Emmanuel; Duguet, Alexandre; de Suremain, Nathalie; Petit, Arnaud

2016-06-01

Compliance by residents in pediatrics to pediatric resuscitation guidelines is low. In many French faculties, a 1-h traditional lecture is still used to educate medical students about pediatric cardiopulmonary arrest (CPA). We developed an innovative pedagogic course combining a 23-min video and 3-h simulation exercises to improve knowledge and skills of medical students. A prospective controlled study was conducted. Medical student knowledge was tested before, just after, and 6-12 months after the innovative course and compared to that of a cohort who attended the traditional lecture. A high-fidelity mannequin simulator simulating cardiopulmonary arrest was used to assess and compare the skills of the study and control groups. Costs of the courses were evaluated; 809 of 860 (94 %) medical students were assessed for knowledge. Six to 12 months after the courses, the median score was significantly higher for the innovative group than that for the traditional lecture group (p < 0.001). In terms of skills, student in the innovative group scored higher on the performance score than the control group (p < 0.01). The innovative course was 24 times more expensive. Combination of video and simulation allows better retention of knowledge than a traditional lecture and leads to better compliance to resuscitation guidelines. • Compliance by residents to pediatric resuscitation guidelines is low. • We developed an innovative pedagogic course combining an educational video and simulation. What is new: • Knowledge retention after the innovative course was better than after a traditional lecture. • Sixty-six students tested on their skills demonstrated better compliance to resuscitation guidelines.

Brief, Embedded, Spontaneous Metacognitive Talk Indicates Thinking Like a Physicist

ERIC Educational Resources Information Center

Sayre, Eleanor C.; Irving, Paul W.

2015-01-01

Instructors and researchers think "thinking like a physicist" is important for students' professional development. However, precise definitions and observational markers remain elusive. We reinterpret popular beliefs inventories in physics to indicate what physicists think thinking like a physicist entails. Through discourse analysis of…

Serious game versus online course for pretraining medical students before a simulation-based mastery learning course on cardiopulmonary resuscitation: A randomised controlled study.

PubMed

Drummond, David; Delval, Paul; Abdenouri, Sonia; Truchot, Jennifer; Ceccaldi, Pierre-François; Plaisance, Patrick; Hadchouel, Alice; Tesnière, Antoine

2017-12-01

Although both recorded lectures and serious games have been used to pretrain health professionals before simulation training on cardiopulmonary resuscitation, they have never been compared. The aim of this study was to compare an online course and a serious game for pretraining medical students before simulation-based mastery learning on the management of sudden cardiac arrest. A randomised controlled trial. Participants were pretrained using the online course or the serious game on day 1 and day 7. On day 8, each participant was evaluated repeatedly on a scenario of cardiac arrest until reaching a minimum passing score. Department of Simulation in Healthcare in a French medical faculty. Eighty-two volunteer second-year medical students participated between June and October 2016 and 79 were assessed for primary outcome. The serious game used was Staying Alive, which involved a 3D realistic environment, and the online course involved a PowerPoint lecture. The median total training time needed for students to reach the minimum passing score on day 8. This same outcome was also assessed 4 months later. The median training time (interquartile range) necessary for students to reach the minimum passing score was similar between the two groups: 20.5 (15.8 to 30.3) minutes in the serious game group versus 23 (15 to 32) minutes in the online course group, P = 0.51. Achieving an appropriate degree of chest compression was the most difficult requirement to fulfil for students in both groups. Four months later, the median training time decreased significantly in both groups, but no correlation was found at an individual level with the training times observed on day 8. The serious game used in this study was not superior to an online course to pretrain medical students in the management of a cardiac arrest. The absence of any correlation between the performances of students evaluated during two training sessions separated by 4 months suggests that some elements in the management of cardiac arrest such as compression depth can only be partially learned and retained after a simulation-based training. ClinicalTrials.gov-NCT02758119.

The current status of education and career paths of students after completion of medical physicist programs in Japan: a survey by the Japanese Board for Medical Physicist Qualification.

PubMed

Kadoya, Noriyuki; Karasawa, Kumiko; Sumida, Iori; Arimura, Hidetaka; Yamada, Syogo

2015-07-01

To standardize educational programs and clinical training for medical physics students, the Japanese Board for Medical Physicist Qualification (JBMP) began to accredit master's, doctorate, and residency programs for medical physicists in 2012. At present, 16 universities accredited by the JBMP offer 22 courses. In this study, we aimed to survey the current status of educational programs and career paths of students after completion of the medical physicist program in Japan. A questionnaire was sent in August 2014 to 32 universities offering medical physicist programs. The questionnaire was created and organized by the educational course certification committee of the JBMP and comprised two sections: the first collected information about the university attended, and the second collected information about characteristics and career paths of students after completion of medical physicist programs from 2008 to 2014. Thirty universities (16 accredited and 14 non-accredited) completed the survey (response rate 94 %). A total of 209, 40, and 3 students graduated from the master's, doctorate, and residency programs, respectively. Undergraduates entered the medical physicist program constantly, indicating an interest in medical physics among undergraduates. A large percentage of the students held a bachelor's degree in radiological technology (master's program 94 %; doctorate program 70 %); graduates obtained a national radiological technologist license. Regarding career paths, although the number of the graduates who work as medical physicist remains low, 7 % with a master's degree and 50 % with a doctorate degree worked as medical physicists. Our results could be helpful for improving the medical physicist program in Japan.

MO-E-213-02: Medical Physicist Involvement in Implementing Patient Protection Standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seibert, J.

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

MO-E-213-01: Increasing Role of Medical Physicist in Radiation Protection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rehani, M.

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

Before Big Science: The Pursuit of Modern Chemistry and Physics 1800-1940

NASA Astrophysics Data System (ADS)

Todd, David

1997-07-01

Mary Jo Nye. Twayne, An Imprint of Simon & Schuster Macmillan: New York, 1996. 282 pp, 11 illus. ISBN 0-8057-9512-X. Cloth. $32.95. Mary Jo Nye, Professor of Humanities and History at Oregon State University, has, since at least 1972, been publishing in the area of the history of science - in particular, physics and chemistry. Her latest book goes at length into the difficulties encountered by 19th century chemists in working out relative atomic weights and the geometry of bound carbon, and by physicists in coping with the problems of the nature of light, whether heat was a fluid or not, and the mechanical equivalent of heat, and problems posed by magnetism and electricity. An example of the mental blocks that had to be overcome is the author's quotation of a French chemist's statement to his students in the late 19th century that "bodies which are not volatile do not have molecular weight", since their molecular weights could not be determined by the Dumas method.

Observational astrophysics.

NASA Astrophysics Data System (ADS)

Léna, P.; Lebrun, F.; Mignard, F.

This book is the 2nd edition of an English translation published in 1988 (45.003.105) of the French original "Astrophysique: Méthodes physiques de l'observation" published in 1986 (42.003.048). Written specifically for physicists and graduate students in astronomy, this textbook focuses on astronomical observation and on the basic physical principles that astronomers use to conceive, build and exploit their instruments at their ultimate limits in sensitivity or resolution. This second edition has been entirely restructured and almost doubled in size, in order to improve its clarity and to account for the great progress achieved in the last 15 years. It deals with ground-based and space-based astronomy and their respective fields. It presents the new generation of giant ground-based telescopes, with the new methods of optical interferometry and adaptive optics, and also the ambitious concepts behind planned space missions for the next decades. Avoiding particulars, it covers the whole of the electromagnetic spectrum and touches upon the "new astronomies" becoming possible with gravitational waves and neutrinos.

Secret Lives of the Hidden Physicists---from Spandex to Spintronics

NASA Astrophysics Data System (ADS)

White, Gary

2006-10-01

What is a physicist? A case is made for defining a physicist as anyone with a bachelor's degree (or higher) in physics. Under this definition, a large fraction of physicists are hidden, that is, they have left, or never belonged to, the traditional lot of Ph.D. academicians. Data from the Statistical Research Center at the American Institute of Physics and from a survey of members of the national physics honor society, Sigma Pi Sigma, show the vast array of actual career paths taken by physicists. From spandex to blackberries to bioinformatics to flight control to wind energy to spintronics, physicists can be found in nearly every job sector in some of the coolest and most farfetched careers imaginable.

[Chronic kidney disease and kidney transplantation].

PubMed

Thuret, R; Timsit, M O; Kleinclauss, F

2016-11-01

To report epidemiology and characteristics of end-stage renal disease (ESRD) patients and renal transplant candidates, and to evaluate access to waiting list and results of renal transplantation. An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords: "chronic kidney disease, epidemiology, kidney transplantation, cost, survival, graft, brain death, cardiac arrest, access, allocation". French legal documents have been reviewed using the government portal (http://www.legifrance.gouv.fr). Articles were selected according to methods, language of publication and relevance. The reference lists were used to identify additional historical studies of interest. Both prospective and retrospective series, in French and English, as well as review articles and recommendations were selected. In addition, French national transplant and health agencies (http://www.agence-biomedecine.fr and http://www.has-sante.fr) databases were screened using identical keywords. A total of 3234 articles, 6 official reports and 3 newspaper articles were identified; after careful selection 99 publications were eligible for our review. The increasing prevalence of chronic kidney disease (CKD) leads to worsen organ shortage. Renal transplantation remains the best treatment option for ESRD, providing recipients with an increased survival and quality of life, at lower costs than other renal replacement therapies. The never-ending lengthening of the waiting list raises issues regarding treatment strategies and candidates' selection, and underlines the limits of organ sharing without additional source of kidneys available for transplantation. Allocation policies aim to reduce medical or geographical disparities regarding enrollment on a waiting list or access to an allotransplant. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Superconductivity in doped fullerenes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hebard, A.F.

1992-11-01

While there is not complete agreement on the microscopic mechanism of superconductivity in alkali-metal-doped C[sub 60], further research may well lead to the production of analogous materials that lose resistance at even higher temperatures. Carbon 60 is a fascinating and arrestingly beautiful molecule. With 12 pentagonal and 20 hexagonal faces symmetrically arrayed in a soccer-ball-like structure that belongs to the icosahedral point group, I[sub h], its high symmetry alone invites special attention. The publication in September 1990 of a simple technique for manufacturing and concentrating macroscopic amounts of this new form of carbon announced to the scientific community that enablingmore » technology had arrived. Macroscopic amounts of C[sub 60] (and the higher fullerenes, such as C[sub 70] and C[sub 84]) can now be made with an apparatus as simple as an arc furnace powered with an arc welding supply. Accordingly, chemists, physicists and materials scientists have joined forces in an explosion of effort to explore the properties of this unusual molecular building block. 23 refs., 6 figs.« less

Mechanical Properties of Semiconductors and Their Alloys

DTIC Science & Technology

1992-02-01

Sher, Associate Director M.A. Berding, Research Physicist A.T. Paxton, International Fellow S. Krishnamurthy, Research Physicist Physical Electronics...Laboratory A.-B. Chen Auburn University Auburn, Alabama SRI Project 6682 Prepared for: . - Office of Scientific Research United States Air Force...THEIR ALLOYS A. Sher, Associate Director M.A. Berding, Research Physicist A.T. Paxton, International Fellow S. Knshnamurthy, Research Physicist Physical

Nuclear Physicists in Finance

NASA Astrophysics Data System (ADS)

Mattoni, Carlo

2017-01-01

The financial services industry presents an interesting alternative career path for nuclear physicists. Careers in finance typically offer intellectual challenge, a fast pace, high caliber colleagues, merit-based compensation with substantial upside, and an opportunity to deploy skills learned as a physicist. Physicists are employed at a wide range of financial institutions on both the ``buy side'' (hedge fund managers, private equity managers, mutual fund managers, etc.) and the ``sell side'' (investment banks and brokerages). Historically, physicists in finance were primarily ``quants'' tasked with applying stochastic calculus to determine the price of financial derivatives. With the maturation of the field of derivative pricing, physicists in finance today find work in a variety of roles ranging from quantification and management of risk to investment analysis to development of sophisticated software used to price, trade, and risk manage securities. Only a small subset of today's finance careers for physicists require the use of advanced math and practically none provide an opportunity to tinker with an apparatus, yet most nevertheless draw on important skills honed during the training of a nuclear physicist. Intellectually rigorous critical thinking, sophisticated problem solving, an attention to minute detail and an ability to create and test hypotheses based on incomplete information are key to both disciplines.

Some Interesting Data About Women Physicists in Cuba (abstract)

NASA Astrophysics Data System (ADS)

de Fuentes, Olimpia Arias

2009-04-01

Although the number of women physicists in Cuba, as in the entire world, is less than men physicists, their presence in the academic leadership is strong, unlike the limited women's role in many other countries. Some interesting numeral data are presented to demonstrate this affirmation. This fact emphasizes the advantages reached by women and the increasing prestige obtained by women physicists in our country.

MO-E-213-03: Newer Radiation Protection Requirements in Last Decade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, J.

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

MO-E-213-00: What Is Medical Physics Without Radiation Safety?

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

Future trends in the supply and demand for radiation oncology physicists.

PubMed

Mills, Michael D; Thornewill, Judah; Esterhay, Robert J

2010-04-12

Significant controversy surrounds the 2012 / 2014 decision announced by the Trustees of the American Board of Radiology (ABR) in October of 2007. According to the ABR, only medical physicists who are graduates of a Commission on Accreditation of Medical Physics Education Programs, Inc. (CAMPEP) accredited academic or residency program will be admitted for examination in the years 2012 and 2013. Only graduates of a CAMPEP accredited residency program will be admitted for examination beginning in the year 2014. An essential question facing the radiation oncology physics community is an estimation of supply and demand for medical physicists through the year 2020. To that end, a Demand & Supply dynamic model was created using STELLA software. Inputs into the model include: a) projected new cancer incidence and prevalence 1990-2020; b) AAPM member ages and retirement projections 1990-2020; c) number of ABR physics diplomates 1990-2009; d) number of patients per Qualified Medical Physicist from Abt Reports I (1995), II (2002) and III (2008); e) non-CAMPEP physicists trained 1990-2009 and projected through 2014; f) CAMPEP physicists trained 1993-2008 and projected through 2014; and g) working Qualified Medical Physicists in radiation oncology in the United States (1990-2007). The model indicates that the number of qualified medical physicists working in radiation oncology required to meet demand in 2020 will be 150-175 per year. Because there is some elasticity in the workforce, a portion of the work effort might be assumed by practicing medical physicists. However, the minimum number of new radiation oncology physicists (ROPs) required for the health of the profession is estimated to be 125 per year in 2020. The radiation oncology physics community should plan to build residency programs to support these numbers for the future of the profession.

Postdoctoral Opportunities in Medical Physics

NASA Astrophysics Data System (ADS)

Hogstrom, Kenneth

2006-04-01

The medical physicist is a professional who specializes in the application of the concepts and methods of physics to the diagnosis and treatment of human disease. Medical physicists identify their primary discipline to be radiation therapy (78%), medical imaging (16%), nuclear medicine (3%), or radiation safety (2%). They state their primary responsibility to be clinical (78%), academic (9%), research (4%), etc. Correspondingly, medical physicists reveal their primarily employment to be a private hospital (42%), university hospital (32%), physicist's service group (9%), physician's service group (9%), industry (5%), and government (3%). The most frequent job of medical physicists is clinical radiation therapy physicist, whose clinical duties include: equipment acquisition, facility design, commissioning, machine maintenance, calibration and quality assurance, patient treatment planning, patient dose calculation, management of patient procedures, development of new technology, radiation safety, and regulatory compliance. The number of medical physicists in the United States can be estimated by the number of members of the American Association of Physicists in Medicine (AAPM), which has increased 5.5% annually since 1969, currently being 5,000. New positions plus retirements create a current need >300 new medical physicists per year, which exceeds supply. This is supported by the steady growth in average salaries, being 100,000 for PhDs entering the field and reaching 180,000. Graduate programs alone cannot meet demand, and physicists entering the field through postdoctoral training in medical physics remain important. Details of postdoctoral research programs and medical physics residency programs will provide direction to physics PhD graduates interested in medical physics. [The AAPM, its annual Professional Information Report, and its Public Education Committee are acknowledged for information contributing to this presentation.

Medical physics aspects of cancer care in the Asia Pacific region

PubMed Central

Kron, T; Cheung, KY; Dai, J; Ravindran, P; Soejoko, D; Inamura, K; Song, JY; Bold, L; Srivastava, R; Rodriguez, L; Wong, TJ; Kumara, A; Lee, CC; Krisanachinda, A; Nguyen, XC; Ng, KH

2008-01-01

Medical physics plays an essential role in modern medicine. This is particularly evident in cancer care where medical physicists are involved in radiotherapy treatment planning and quality assurance as well as in imaging and radiation protection. Due to the large variety of tasks and interests, medical physics is often subdivided into specialties such as radiology, nuclear medicine and radiation oncology medical physics. However, even within their specialty, the role of radiation oncology medical physicists (ROMPs) is diverse and varies between different societies. Therefore, a questionnaire was sent to leading medical physicists in most countries/areas in the Asia/Pacific region to determine the education, role and status of medical physicists. Answers were received from 17 countries/areas representing nearly 2800 radiation oncology medical physicists. There was general agreement that medical physicists should have both academic (typically at MSc level) and clinical (typically at least 2 years) training. ROMPs spent most of their time working in radiotherapy treatment planning (average 17 hours per week); however radiation protection and engineering tasks were also common. Typically, only physicists in large centres are involved in research and teaching. Most respondents thought that the workload of physicists was high, with more than 500 patients per year per physicist, less than one ROMP per two oncologists being the norm, and on average, one megavoltage treatment unit per medical physicist. There was also a clear indication of increased complexity of technology in the region with many countries/areas reporting to have installed helical tomotherapy, IMRT (Intensity Modulated Radiation Therapy), IGRT (Image Guided Radiation Therapy), Gamma-knife and Cyber-knife units. This and the continued workload from brachytherapy will require growing expertise and numbers in the medical physics workforce. Addressing these needs will be an important challenge for the future. PMID:21611001

Synergistic inhibitory effects of deferasirox in combination with decitabine on leukemia cell lines SKM-1, THP-1, and K-562.

PubMed

Li, Nianyi; Chen, Qinfen; Gu, Jingwen; Li, Shuang; Zhao, Guangjie; Wang, Wei; Wang, Zhicheng; Wang, Xiaoqin

2017-05-30

A multi-center study from the French Myelodysplastic Syndrome (MDS) Group confirmed that iron chelation therapy is an independent prognostic factor that can increase the survival rate of patients who are suffering from transfusion-dependent low-risk MDS. In this study, we aimed to explore this clinical phenomena in vitro, by exploring the synergistic effect of the iron chelator Deferasirox (DFX) and the DNA methyl transferase inhibitor Decitabine (DAC) in the leukemia cell lines SKM-1, THP-1, and K-562. Treatment with both DFX or DAC promoted apoptosis, induced cell cycle arrest, and inhibited proliferation in all three of these cell lines. The combination of DFX and DAC was much greater than the effect of using either drug alone. DFX showed a synergistic effect with DAC on cell apoptosis in all three cell lines and on cell cycle arrest at the G0/G1 phase in K-562 cells. DFX decreased the ROS levels to varying degrees. In contrast, DAC increased ROS levels and an increase in ROS was also noted when the two drugs were used in combination. Treatment of cells with DAC induced re-expression of ABAT, APAF-1, FADD, HJV, and SMPD3, presumably through demethylation. However the combination of DAC and DFX just had strong synergistic effect on the re-expression of HJV.

Synergistic inhibitory effects of deferasirox in combination with decitabine on leukemia cell lines SKM-1, THP-1, and K-562

PubMed Central

Li, Nianyi; Chen, Qinfen; Gu, Jingwen; Li, Shuang; Zhao, Guangjie; Wang, Wei; Wang, Zhicheng; Wang, Xiaoqin

2017-01-01

A multi-center study from the French Myelodysplastic Syndrome (MDS) Group confirmed that iron chelation therapy is an independent prognostic factor that can increase the survival rate of patients who are suffering from transfusion-dependent low-risk MDS. In this study, we aimed to explore this clinical phenomena in vitro, by exploring the synergistic effect of the iron chelator Deferasirox (DFX) and the DNA methyl transferase inhibitor Decitabine (DAC) in the leukemia cell lines SKM-1, THP-1, and K-562. Treatment with both DFX or DAC promoted apoptosis, induced cell cycle arrest, and inhibited proliferation in all three of these cell lines. The combination of DFX and DAC was much greater than the effect of using either drug alone. DFX showed a synergistic effect with DAC on cell apoptosis in all three cell lines and on cell cycle arrest at the G0/G1 phase in K-562 cells. DFX decreased the ROS levels to varying degrees. In contrast, DAC increased ROS levels and an increase in ROS was also noted when the two drugs were used in combination. Treatment of cells with DAC induced re-expression of ABAT, APAF-1, FADD, HJV, and SMPD3, presumably through demethylation. However the combination of DAC and DFX just had strong synergistic effect on the re-expression of HJV. PMID:28388554

Brief, embedded, spontaneous metacognitive talk indicates thinking like a physicist

NASA Astrophysics Data System (ADS)

Sayre, Eleanor C.; Irving, Paul W.

2015-12-01

[This paper is part of the Focused Collection on Upper Division Physics Courses.] Instructors and researchers think "thinking like a physicist" is important for students' professional development. However, precise definitions and observational markers remain elusive. We reinterpret popular beliefs inventories in physics to indicate what physicists think thinking like a physicist entails. Through discourse analysis of upper-division students' speech in natural settings, we show that students may appropriate or resist these elements. We identify a new element in the physicist speech genre: brief, embedded, spontaneous metacognitive talk (BESM talk). BESM talk communicates students' in-the-moment enacted expectations about physics as a technical field and a cultural endeavor. Students use BESM talk to position themselves as physicists or nonphysicists. Students also use BESM talk to communicate their expectations in four ways: understanding, confusion, spotting inconsistencies, and generalized expectations.

Blindness and the age of enlightenment: Diderot's letter on the blind.

PubMed

Margo, Curtis E; Harman, Lynn E; Smith, Don B

2013-01-01

Several months after anonymously publishing an essay in 1749 with the title "Letter on the Blind for the Use of Those Who Can See," the chief editor of the French Encyclopédie was arrested and taken to the prison fortress of Vincennes just east of Paris, France. The correctly assumed author, Denis Diderot, was 35 years old and had not yet left his imprint on the Age of Enlightenment. His letter, which recounted the life of Nicolas Saunderson, a blind mathematician, was intended to advance secular empiricism and disparage the religiously tinged rationalism put forward by Rene Descartes. The letter's discussion of sensory perception in men born blind dismissed the supposed primacy of visual imagery in abstract thinking. The essay did little to resolve any philosophical controversy, but it marked a turning point in Western attitudes toward visual disability.

The specifics of superconductivity

NASA Astrophysics Data System (ADS)

Grant, Paul M.

2011-07-01

When addressing the general audience of any scientific discipline, it is wise to remember Abraham Lincoln, who (almost) said "You can please all physicists some of the time and some physicists all of the time, but never all physicists all of the time."

Diagnostic medical physicists and their clinical activities.

PubMed

Cypel, Yasmin S; Sunshine, Jonathan H

2004-02-01

The primary objective of this study was to obtain basic, descriptive information about medical physicists involved in diagnostic radiology-related activities, the diagnostic-related activities that they performed, and the time spent on these activities. A survey was sent to a randomly selected sample of 1511 medical physicists from July through October 2001 using primarily e-mail methods; a total of 851 surveys was received, for a response rate of 56%. Of these, 427 were responses from physicists who do partly or only clinical diagnostic medical physics; it is this group for which results are presented. Fifty-four percent of the physicists who reported doing any clinical diagnostic medical physics performed clinical activities only in diagnostic medical physics. Fourteen percent of all those doing clinical diagnostic medical physics were women. Over 97% of the physicists doing clinical diagnostic medical physics reported having graduate degrees in physics; 53% had PhDs. The mean total weekly hours worked by physicists doing clinical diagnostic medical physics was 42. Medical physicists doing only clinical diagnostic activities reported working approximately 40 hours weekly, whereas those doing partly clinical diagnostic medical physics reported working 14 hours weekly in the field (approximately one-third of their work time). Radiography and fluoroscopy, computed tomography, nuclear medicine, and mammography are all fields in which the majority of those doing any clinical diagnostic medical physics are active. Full-time physicists working only in diagnostic medical physics were responsible for a median of 25 units of equipment, compared with a median of 10 units for those working only partly in the field. Number of units evaluated, frequency of evaluation, and hours per evaluation were reported for almost 20 types of equipment. Medical physicists performing diagnostic clinical activities typically are responsible for a large number and wide variety of imaging equipment. It would be helpful to study their work further, focusing in particular on whether there is a shortage, as is true of diagnostic radiologists, and whether the variety of responsibilities creates strain.

SU-E-P-01: An Informative Review On the Role of Diagnostic Medical Physicist in the Academic and Private Medical Centers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weir, V; Zhang, J

Purpose: The role of physicist in the academic and private hospital environment continues to evolve and expand. This becomes more obvious with the newly revised requirements of the Joint Commission (JC) on imaging modalities and the continued updated requirements of ACR accreditation for medical physics (i.e., starting in June 2014, a physicists test will be needed before US accreditation). We provide an informative review on the role of diagnostic medical physicist and hope that our experience will expedite junior physicists in understanding their role in medical centers, and be ready to more opportunities. Methods: Based on our experience, diagnostic medicalmore » physicists in both academic and private medical centers perform several clinical functions. These include providing clinical service and physics support, ensuring that all ionizing radiation devices are tested and operated in compliance with the State and Federal laws, regulations and guidelines. We also discuss the training and education required to ensure that the radiation exposure to patients and staff is as low as reasonably achievable. We review the overlapping roles of medical and health physicist in some institutions. Results: A detailed scheme on the new requirements (effective 7/1/2014) of the JC is provided. In 2015, new standards for fluoroscopy, cone beam CT and the qualifications of staff will be phased in. A summary of new ACR requirements for different modalities is presented. Medical physicist have other duties such as sitting on CT and fluoroscopy committees for protocols design, training of non-radiologists to meet the new fluoroscopy rules, as well as helping with special therapies such as Yittrium 90 cases. Conclusion: Medical physicists in both academic and private hospitals are positioned to be more involved and prominent. Diagnostic physicists need to be more proactive to involve themselves in the day to day activities of the radiology department.« less

Mário Schenberg: Physicist, politician and art critic

NASA Astrophysics Data System (ADS)

Guzzo, M. M.; Reggiani, N.

2015-12-01

Mário Schenberg is considered one of the greatest theoretical physicists of Brazil. He worked in different fields of physics including thermodynamics, quantum mechanics, statistical mechanics, general relativity, astrophysics and mathematics. He was assistant of the Ukrainian naturalized Italian physicist Gleb Wataghin and worked with prestigious physicists like as the Brazilians José Leite Lopes and César Lattes, the Russian-born American George Gamow and the Indian astrophysicist Subrahmanyan Chandrasekhar. Besides, he was also an active politician and critic of art.

Mário Schenberg: Physicist, politician and art critic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guzzo, M. M., E-mail: guzzo@ifi.unicamp.br; Reggiani, N.

2015-12-17

Mário Schenberg is considered one of the greatest theoretical physicists of Brazil. He worked in different fields of physics including thermodynamics, quantum mechanics, statistical mechanics, general relativity, astrophysics and mathematics. He was assistant of the Ukrainian naturalized Italian physicist Gleb Wataghin and worked with prestigious physicists like as the Brazilians José Leite Lopes and César Lattes, the Russian-born American George Gamow and the Indian astrophysicist Subrahmanyan Chandrasekhar. Besides, he was also an active politician and critic of art.

LGBT Roundtable Discussion: Meet-up and Mentoring Discussion

NASA Astrophysics Data System (ADS)

2014-03-01

The LGBT+ Physicists group welcomes those who identify as gender sexual minorities, as LGBTQQIAAP+, or as allies to participate in a round-table discussion on mentoring physicists. The session will provide an opportunity to learn and discuss successful mentoring strategies at different career stages for physicists in all environments, including academia, industry, etc. Attendees are encouraged to attend a social event to follow the panel to continue to network. Allies are especially welcome at this event to learn how to support and mentor LGBT+ physicists.

Cardiac arrest in the workplace and its outcome: a systematic review and meta-analysis.

PubMed

Descatha, Alexis; Dagrenat, Céline; Cassan, Pascal; Jost, Daniel; Loeb, Thomas; Baer, Michel

2015-11-01

Out-of-hospital cardiac arrest (OHCA) in the workplace appears to be managed more effectively than OHCA occurring in other places. A systematic review and meta-analysis of the available epidemiological data was performed, comparing the rate of survival for OHCA in the workplace, versus survival in other locations. Four databases (Pub-Med, Scopus, Web of science, "Base de Données de Santé Publique", BDSP, i.e. the French Public Health Database) were searched from 01/2000 to 03/2015, using the key words: ("Cardiac arrest") and ("occupational" OR "workplace" OR "public location"). A two stage process with two independent readers was used to select relevant papers. Numbers of subjects who suffered from OHCA in the workplace versus other locations were extracted when possible, as well as their respective outcomes (admitted alive to the hospital, discharged alive, good neurological outcome). Metarisks were calculated using the generic variance approach (meta-odds ratios metaOR). After full-text reading, 17 papers were included, from 9 countries, mostly published after 2005, and coming mostly from prospective registers. "Workplace" was defined differently in different studies, mostly in terms of industrial sites and offices. The workplace was an exceptional location for occurrences of OHCA (from 0.3% to 4.7% of all OHCA, from 1.3 to 23.8 events per million people per year), based on 2077 OHCA. In the quantitative analyses (survival available, 10 studies), MetaOR were found to be relatively consistent and high (from 1.9 (1.5-2.3) to 5.9(2.7-13.0)). When OHCA occurring at workplaces were compared to other public sites, no significant differences were found. There is sufficient evidence to support the view that there will be better outcomes for OHCA cases that occur in the workplace than for those occurring elsewhere. Requirements for occupational health and safety should include prevention of such major (albeit rare) events. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Major traumatic complications after out-of-hospital cardiac arrest: Insights from the Parisian registry.

PubMed

Champigneulle, B; Haruel, P A; Pirracchio, R; Dumas, F; Geri, G; Arnaout, M; Paul, M; Pène, F; Mira, J P; Bougouin, W; Cariou, A

2018-07-01

Due to collapse and cardiopulmonary resuscitation (CPR) maneuvers, major traumatic injuries may complicate the course of resuscitation for out-of-hospital cardiac arrest patients (OHCA). Our goals were to assess the prevalence of these injuries, to describe their characteristics and to identify predictive factors. We conducted an observational study over a 9-year period (2007-2015) in a French cardiac arrest (CA) center. All non-traumatic OHCA patients admitted alive in the ICU were studied. Major injuries identified were ranked using a functional two-level scale of severity (life-threatening or consequential) and were classified as CPR-related injuries or collapse-related injuries, depending of the predominant mechanism. Factors associated with occurrence of a CPR-related injury and ICU survival were identified using multivariable logistic regression. A major traumatic injury following OHCA was observed in 91/1310 patients (6.9%, 95%CI: 5.6, 8.3%), and was classified as a life-threatening injury in 36% of cases. The traumatic injury was considered as contributing to the death in 19 (21%) cases. Injuries were related to CPR maneuvers in 65 patients (5.0%, (95%CI: 3.8, 6.1%)). In multivariable analysis, age [OR 1.02; 95%CI (1.00, 1.04); p = 0.01], male gender [OR 0.53; 95%CI (0.31, 0.91); p = 0.02] and CA occurring at home [OR 0.54; 95%CI (0.31, 0.92); p = 0.02] were significantly associated with the occurrence of a CPR-related injury. CPR-related injuries were not associated with the ICU survival [OR 0.69; 95%CI (0.36, 1.33); p = 0.27]. Major traumatic injuries are common after cardiopulmonary resuscitation. Further studies are necessary to evaluate the interest of a systematic traumatic check-up in resuscitated OHCA patients in order to detect these injuries. Copyright © 2018 Elsevier B.V. All rights reserved.

[Adélaïde Hautval (1906-1988): An exemplary medical personality].

PubMed

Halioua, Bruno; Hauptmann, Georges

2015-12-01

Adélaïde Hautval (1906-1988), psychiatrist, was arrested in April 1942 having defended a Jewish family abused by German soldiers. She was imprisoned in Bourges and in several camps in France (Pithiviers, Beaune-la-Rolande, Orléans, Romainville) before being deported as a "Friend of the Jews" at Auschwitz in the convoy of 23 January 1943, said 31,000 convoy with 229 other resistant women, Marie-Claude Vaillant-Couturier, Charlotte Delbo, Danielle Casanova. She refused to participate in the "medical" experience of Nazi doctors Clauberg, Schumann, Wirths and Mengele at Birkenau. She was then deported to Ravensbrück. During her deportation, she illustrated her dedication in the medical management of the deportees. She testified repeatedly on her experience of remote doctor. Hautval Adélaïde was the first French woman doctor named Righteous among the Nations in 1965. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

Code of Federal Regulations, 2011 CFR

2011-01-01

..., teletherapy or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF... pharmacist, and authorized nuclear pharmacist. (a)(1) An individual identified as a Radiation Safety Officer...

10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

Code of Federal Regulations, 2014 CFR

2014-01-01

..., teletherapy or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF... pharmacist, and authorized nuclear pharmacist. (a)(1) An individual identified as a Radiation Safety Officer...

10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

Code of Federal Regulations, 2012 CFR

2012-01-01

..., teletherapy or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF... pharmacist, and authorized nuclear pharmacist. (a)(1) An individual identified as a Radiation Safety Officer...

10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

Code of Federal Regulations, 2013 CFR

2013-01-01

..., teletherapy or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF... pharmacist, and authorized nuclear pharmacist. (a)(1) An individual identified as a Radiation Safety Officer...

10 CFR 35.57 - Training for experienced Radiation Safety Officer, teletherapy or medical physicist, authorized...

Code of Federal Regulations, 2010 CFR

2010-01-01

..., teletherapy or medical physicist, authorized medical physicist, authorized user, nuclear pharmacist, and authorized nuclear pharmacist. 35.57 Section 35.57 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF... pharmacist, and authorized nuclear pharmacist. (a)(1) An individual identified as a Radiation Safety Officer...

Physicists and Astronomy--Will You Join the Dance?

ERIC Educational Resources Information Center

Harwit, Martin

1981-01-01

Focuses on past achievements of physicists beginning with the discovery of gaseous nebulae and listing seven commonly found characteristics of this and other observational discoveries which can foster further discovery. Suggests how theory is related to observation and where physicists make their greatest contributions to astronomy. (Author/JN)

The Role of the Medical Physicist in Radiation Protection in Hospitals.

ERIC Educational Resources Information Center

Harrison, R. M.

1989-01-01

Described is the role of the medical physicist in five areas of medical application, including radiotherapy, nuclear medicine, diagnostic radiology, environmental radioactivity, and dosimetry and personal monitoring. The management contribution of the medical physicist is discussed. Provided are two examples of new techniques influencing radiation…

Fermilab Today

Science.gov Websites

physicist invents new way to clean up oil spills Fermilab physicist Arden Warner revolutionizes oil spill cleanup with magnetizable-oil invention. Photo: Hanae Armitage Four years ago, Fermilab accelerator physicist Arden Warner watched national news of the BP oil spill and found himself frustrated with the

Identical Collision Terms/Solutions of Kinetic Eqn. and Explanation of Damping of Waves in Plasmas and Solids Known by Different Names

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharma, S. K.

2010-11-23

In this paper we show that identical collision terms are known by different names in gaseous plasmas and solids. Method used by plasma physicists and the one used by solid state physicists to solve Kinetic equation are also exactly same but they are also known by different names. In fact the physical explanation of damping of plasma Waves given by plasma physicists is quite similar to that given by solid state physicists to explain the absorption of acoustic waves in solids.

Physics in Industry: A Case Study

NASA Astrophysics Data System (ADS)

Pratt-Ferguson, Ben

2007-10-01

Often ignored and sometimes even considered ``black sheep'' by the university & government-lab physicists, many industrial physicists continue making valuable scientific contributions in diverse areas, from computer science to aero and thermo-dynamics, communications, mathematics, engineering, and simulation, to name a few. This talk will focus on what industrial physicists do, what preparations are beneficial to obtaining a first industrial job, and what the business environment is like for physicists. The case study will be that of the author, starting with undergraduate and graduate studies and continuing on to jobs in industry.

A Gendered Approach to Science Ethics for US and UK Physicists.

PubMed

Ecklund, Elaine Howard; Di, Di

2017-02-01

Some research indicates that women professionals-when compared to men-may be more ethical in the workplace. Existing literature that discusses gender and ethics is confined to the for-profit business sector and primarily to a US context. In particular, there is little attention paid to gender and ethics in science professions in a global context. This represents a significant gap, as science is a rapidly growing and global professional sector, as well as one with ethically ambiguous areas. Adopting an international comparative perspective, this paper relies on 121 semi-structured interviews with US and UK academic physicists to examine how physicists perceive the impact of gender on science ethics. Findings indicate that some US and UK physicists believe that female scientists handle ethical issues within science in a feminine way whereas their male colleagues approach ethics in a masculine way. Some of these physicists further claim that these different approaches to science ethics lead to male and female scientists' different levels of competitiveness in academic physics. In both the US and the UK, there are "gender-blind" physicists, who do not think gender is related to professional ethics. Relying on physicists' nuanced descriptions this paper contributes to the current understanding of gender and science and engineering ethics.

Medical physics in radiotherapy: The importance of preserving clinical responsibilities and expanding the profession's role in research, education, and quality control

PubMed Central

Malicki, Julian

2015-01-01

Medical physicists have long had an integral role in radiotherapy. In recent decades, medical physicists have slowly but surely stepped back from direct clinical responsibilities in planning radiotherapy treatments while medical dosimetrists have assumed more responsibility. In this article, I argue against this gradual withdrawal from routine therapy planning. It is essential that physicists be involved, at least to some extent, in treatment planning and clinical dosimetry for each and every patient; otherwise, physicists can no longer be considered clinical specialists. More importantly, this withdrawal could negatively impact treatment quality and patient safety. Medical physicists must have a sound understanding of human anatomy and physiology in order to be competent partners to radiation oncologists. In addition, they must possess a thorough knowledge of the physics of radiation as it interacts with body tissues, and also understand the limitations of the algorithms used in radiotherapy. Medical physicists should also take the lead in evaluating emerging challenges in quality and safety of radiotherapy. In this sense, the input of physicists in clinical audits and risk assessment is crucial. The way forward is to proactively take the necessary steps to maintain and advance our important role in clinical medicine. PMID:25949219

The Preston of the Guinier-Preston Zones. Guinier

NASA Astrophysics Data System (ADS)

Hardouin Duparc, O. B. M.

2010-10-01

Almost all materials scientists know about the Guinier-Preston (GP) zones, which were discovered in age-hardened aluminum-copper alloys in 1938. One of the discoverers, the French André Guinier, is rightly well known. The other discoverer, the British G.D. Preston, is totally ignored, even in English scientific biographies. I wish here to partly make up for this “oblivion” by giving elements about George Preston’s life (August 8, 1896 to June 22, 1972) and scientific work. Born in Ireland to the physicist Thomas Preston and deceased in Scotland, G. Preston carried out his scientific achievements in England, mainly studying the crystallographic structure of metals, metallic alloys, and thin films of metal oxides in a pioneering way. He also discussed the atomistic structure of twins in 1927. He mastered many kinds of X-ray and electron diffraction techniques up to diffuse scattering, which allowed him to detect the GP zones. Although he was involved in several controversies, including one about diamonds, he always remained a forthright person until his final professorship in Dundee. André Guinier’s career is briefly recalled in a parallel way.

The Preston of the Guinier-Preston Zones. Guinier

NASA Astrophysics Data System (ADS)

Hardouin Duparc, O. B. M.

2010-08-01

Almost all materials scientists know about the Guinier-Preston (GP) zones, which were discovered in age-hardened aluminum-copper alloys in 1938. One of the discoverers, the French André Guinier, is rightly well known. The other discoverer, the British G.D. Preston, is totally ignored, even in English scientific biographies. I wish here to partly make up for this “oblivion” by giving elements about George Preston’s life (August 8, 1896 to June 22, 1972) and scientific work. Born in Ireland to the physicist Thomas Preston and deceased in Scotland, G. Preston carried out his scientific achievements in England, mainly studying the crystallographic structure of metals, metallic alloys, and thin films of metal oxides in a pioneering way. He also discussed the atomistic structure of twins in 1927. He mastered many kinds of X-ray and electron diffraction techniques up to diffuse scattering, which allowed him to detect the GP zones. Although he was involved in several controversies, including one about diamonds, he always remained a forthright person until his final professorship in Dundee. André Guinier’s career is briefly recalled in a parallel way.

Techniques for hazard analysis and their use at CERN.

PubMed

Nuttall, C; Schönbacher, H

2001-01-01

CERN, The European Organisation for Nuclear Research is situated near Geneva and has its accelerators and experimental facilities astride the Swiss and French frontiers attracting physicists from all over the world to this unique laboratory. The main accelerator is situated in a 27 km underground ring and the experiments take place in huge underground caverns in order to detect the fragments resulting from the collision of subatomic particles at speeds approaching that of light. These detectors contain many hundreds of tons of flammable materials, mainly plastics in cables and structural components, flammable gases in the detectors themselves, and cryogenic fluids such as helium and argon. The experiments consume high amounts of electrical power, thus the dangers involved have necessitated the use of analytical techniques to identify the hazards and quantify the risks to personnel and the infrastructure. The techniques described in the paper have been developed in the process industries where they have been to be of great value. They have been successfully applied to CERN industrial and experimental installations and, in some cases, have been instrumental in changing the philosophy of the experimentalists and their detectors.

MO-C-BRB-04: Observations of a Nuclear Radiologist on the Value of the Medical Physicist

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenspan, B.

With the profound changes currently occurring in medicine, the role of the medical physicist cannot stagnate, but must evolve to meet the challenges and opportunities that are presented. Medical physicists must understand these changes and establish themselves not only as relevant but as leaders in this new environment. We must increase our presence in clinical settings such as tumor boards, patient rounds, and the development of new diagnosis, imaging, and treatment techniques. By establishing ourselves as competent scientists, we can and must participate in the development of technologies through research, teaching, and clinical implementation. As medical physicists we must definemore » our roles and value to our physician colleagues, patients, referring physicians, and senior administrators. We cannot afford to be viewed solely as quality assurance technologists, but need to move forward in step with medical and practice advances, becoming recognized as having a leadership role in providing quality research, technological development, and quality patient care. In this session, four leaders in medical research and healthcare will discuss their observations on how medical physicists have contributed to advancements in healthcare and opportunities to continue leadership in providing quality medicine through the applications of physics to research, education, and clinical practice. Learning Objectives: Understand the changes in the healthcare environment and how medical physicists can contribute to improving patient care. Learn how medical physicists are currently leading research efforts to improve clinical imaging and diagnosis. Understand the role of medical physicists in developing new technology and leading its translation into clinical care.« less

Is the "glass ceiling" a real problem for women physicists in Argentina?

NASA Astrophysics Data System (ADS)

Frechero, Marisa A.; Amador, Ana; Pastor, Antonio J. Ramirez; Tamarit, Francisco

2015-12-01

We evaluate the distribution of female physicists in the Argentinean workforce, analyzing the distribution of women at different levels of education and research using several indicators. Although important imbalances still occur, our findings are encouraging and the distribution of female physicists seems to be changing for the better.

NREL Researcher is Top World Physicist

Science.gov Websites

is Top World Physicist For more information contact: Kerry Masson, (303) 275-4083 e:mail physicists in the world by the Institute of Scientific Information (ISI). The standing is based on the number your peers is the ultimate measure of the quality and quantity of world class research being conducted

Alternate Careers for Physicists: Science Policy and Government Relations

NASA Astrophysics Data System (ADS)

Mack, Gregory

While physics is an investigation of the world around us, physicists and the practice of physics research exist within the world in combination with aspects of society. This means that physicists and physics research are subject to federal policies and regulations that affect how physics is done. Who decides or influences those policies? Who speaks up on our behalf? Who investigates policy issues from a physics point of view? As physicists, we can lend our expertise and insight in order to ensure a fruitful future for physics and science more broadly, whether it be an occasional policy action taken or a career in science policy and government relations. In this talk I'll share the story of my transition from academia to a policy-focused career at APS and what it means to be a physicist on the frontlines of government relations.

Physics and nuclear power

NASA Astrophysics Data System (ADS)

Buttery, N. E.

2008-03-01

Nuclear power owes its origin to physicists. Fission was demonstrated by physicists and chemists and the first nuclear reactor project was led by physicists. However as nuclear power was harnessed to produce electricity the role of the engineer became stronger. Modern nuclear power reactors bring together the skills of physicists, chemists, chemical engineers, electrical engineers, mechanical engineers and civil engineers. The paper illustrates this by considering the Sizewell B project and the role played by physicists in this. This covers not only the roles in design and analysis but in problem solving during the commissioning of first of a kind plant. Looking forward to the challenges to provide sustainable and environmentally acceptable energy sources for the future illustrates the need for a continuing synergy between physics and engineering. This will be discussed in the context of the challenges posed by Generation IV reactors.

The Dark Side of the Earth

NASA Astrophysics Data System (ADS)

Frankel, Henry

1986-10-01

Wood's The Dark Side of the Earth is another addition to the growing list of books on the recent revolution in the earth sciences. Wood rightly points out that any new book on the topic should break new ground. In the preface, he writes of himself and his book that he has benefited from previous accounts by saving himself research time, and that his book, unlike others, “attempts to tell one complete story of the study of the Earth, geologists, geophysicists, dreamers and all” (p. vi). Wood is ambitious, for his work covers much of 19th-century geology as well as the development, reception, rejection, and eventual acceptance of mobilist ideas. Before discussing the work of the German meteorologist and geophysicist Alfred L. Wegener, American glacial geomorphologist Frank Taylor, and several of their predecessors who proposed “mobilist” ideas, he manages to string together brief descriptions of the contributions of (among others) German mineralogist Abraham Gottlob Werner, British geologists James Hutten and John Playfair, British engineer William Smith, British geologist Charles Lyell, American geologists James Hall and James Dwight Dana, British volcanologist William Lowthian Green, American geologist Grove Karl Gilbert, French geologist Elie de Beaumont, British geologist and mathematician Osmond Fisher, American geologist Clarence Dutton, British mathematician and physicist Lord Kelvin, Austrian geologist Eduard Suess, French geologist Marcel Bertrand, and American geologist Thomas Chrowder Chamberlin. Moreover, Wood offers an interesting thesis about the revolution in the earth sciences. He claims that the real revolution was not the replacement of fixist views with the mobilist ones of sea floor spreading and plate tectonics, but rather the replacement of geology with the new discipline of the earth sciences in which geophysics and geochemistry play the central role.

NRG Oncology medical physicists' manpower survey quantifying support demands for multi-institutional clinical trials.

PubMed

Monroe, James I; Boparai, Karan; Xiao, Ying; Followill, David; Galvin, James M; Klein, Eric E; Low, Daniel A; Moran, Jean M; Zhong, Haoyu; Sohn, Jason W

2018-02-04

A survey was created by NRG to assess a medical physicists' percent full time equivalent (FTE) contribution to multi-institutional clinical trials. A 2012 American Society for Radiation Oncology report, "Safety Is No Accident," quantified medical physics staffing contributions in FTE factors for clinical departments. No quantification of FTE effort associated with clinical trials was included. To address this lack of information, the NRG Medical Physics Subcommittee decided to obtain manpower data from the medical physics community to quantify the amount of time medical physicists spent supporting clinical trials. A survey, consisting of 16 questions, was designed to obtain information regarding physicists' time spent supporting clinical trials. The survey was distributed to medical physicists at 1996 radiation therapy institutions included on the membership rosters of the 5 National Clinical Trials Network clinical trial groups. Of the 451 institutions who responded, 50% (226) reported currently participating in radiation therapy trials. On average, the designated physicist at each institution spent 2.4 hours (standard deviation [SD], 5.5) per week supervising or interacting with clinical trial staff. On average, 1.2 hours (SD, 3.1), 1.8 hours (SD, 3.9), and 0.6 hours (SD, 1.1) per week were spent on trial patient simulations, treatment plan reviews, and maintaining a Digital Imaging and Communications in Medicine server, respectively. For all trial credentialing activities, physicists spent an average of 32 hours (SD, 57.2) yearly. Reading protocols and supporting dosimetrists, clinicians, and therapists took an average of 2.1 hours (SD, 3.4) per week. Physicists also attended clinical trial meetings, on average, 1.2 hours (SD, 1.9) per month. On average, physicist spent a nontrivial total of 9 hours per week (0.21 FTE) supporting an average of 10 active clinical trials. This time commitment indicates the complexity of radiation therapy clinical trials and should be taken into account when staffing radiation therapy institutions. Copyright © 2018 Elsevier Inc. All rights reserved.

Lithuanian female physicists: Reality and plans for the future

NASA Astrophysics Data System (ADS)

Šatkovskienė, Dalia; Giriunienė, Ramutė; Ruželė, Živilė; Rutkunienė, Živilė

2013-03-01

Changes in the issue of women in physics in Lithuanian in the three years since the 3rd IUPAP International Conference on Women in Physics are discussed on the basis of statistics as well as an exploratory study recently conducted among women physicists. The situation has changed slowly since 2008. However, the study shows that women physicists more clearly understand the inequities and the need for changes, including an active European Union mainstreaming policy targeted to ensure gender equality in the sciences, which gives hope for accelerating changes. Continued plans for improving women physicists' situation in Lithuania are discussed.

Chinese physicists educated in Germany and America: Their scientific contributions and their impact on China's higher education

NASA Astrophysics Data System (ADS)

Qu, Jing Cheng

1998-11-01

This dissertation records the historical paths of Chinese physicists educated in Germany and America, explores their representative achievements in modern physics that have not been recognized by Chinese scholars, and provides sociological analyses of their contributions to China's higher education. We have found that Chinese students of physics in Germany and America were not passive recipients of Western science, but active contributors. They were also crucial contributors to science education and important scientific projects upon their return to China. Chapter One briefly describes physics knowledge in ancient China and introduces the transplantation of modern science and technology to China. Three distinct historical periods have been identified. In Chapter Two and Chapter Three, 30 Chinese physicists educated in Germany and 89 in America have been investigated. This research analyzes the significant achievements of these physicists. It also examines the political changes, the social background, and other factors impacting on their studies in the two countries. The selected cases in the two chapters are Li Fo-ki, Chinese physics students in Berlin, Werner Heisenberg and his Chinese students, Max Born and his Chinese students, Robert Millikan and Chinese physicists, the first two Chinese physicists from Harvard, and the Science Society of China. Chapter Four explores the geographical distribution, education and careers, return and expatriation, and the social influence exerted by these Chinese physicists. Statistical compilation and quantitative analyses comprise the basic methodology. In terms of two periods and two generations, this dissertation explores the physicists' contributions to the development of modern science in China and to education in China. Significant cases from Beijing University, Qinghua University, and Yanjing University are analyzed. The last chapter, Chapter Five, concludes that some of the achievements of these Chinese physicists were critical steps in modern physics even though China remained domestically rather weak in the development of modern science. Returning to China, most of them became pioneers and active contributors to modern science and to higher education in China. They comprised the majority of the physics community of China and played a leading role in the formation of modern science in China. After 1949, China continued to benefit from the contributions of these physicists. China independently constructed an atomic bomb in 1964 and a hydrogen bomb in 1967. In 1970, China successfully launched a man-made satellite. The Chinese physicists trained in Western countries constituted the main research force behind these projects.

The Status of African American Physicists within the DOE Laboratories

NASA Astrophysics Data System (ADS)

Jackson, Keith

2005-03-01

In May 2002 there was a backpage article published in American Physical Society Newsletter by the President of the National Society of Black Physicists (NSBP). This article showed that of the 3372 professional physicists employed at the DOE national labs, only 11 are African American, which on a percentage basis is 4 times less than the total availability of Ph.D. African American physicists in the labor force. NSBP want to provide an update of the interaction between National Society of Black Physicists (NSBP) and the department of Energy in particular the Office of Science on the issue of employment of African American Physicists in scientific and technical. You might ask the following question: Why should the current generation of African American Physicists be concerned about their underepresentation on the scientific staffs of the DOE National Laboratories? The answer to this question may vary from person to person, but I would like to propose the following: The National Laboratories are the largest providers of career opportunities in Physics in the United States. There is a general view in the community; African Americans are not getting a return on their national investment in the DOE National Labs. Failure to engage with HBCU’s through their user facilities causes a training or skills deficit when it comes to preparing students to participate at the forefront of physics research. By rebuffing interactions with HBCU¹s, as many the laboratories have done, the national laboratories are in effect refusing to transfer scientific knowledge to the stakeholders in the African American community. The update will contain some additional information about NSBP proposals to solve the problem of underepresentation of African American and Hispanic physicists within the National Laboratories and how the Office of Science has response these proposals.

FIAP Forum on Entrepreneurship in Physics

NASA Astrophysics Data System (ADS)

2015-03-01

With the changes in science as globalization has taken root, the future role of physicists becoming a part of the industrial physics community is more imperative. When 80% of graduating physicists will not be employed in academic positions, and 50% of all jobs for these physicists will be industrial sector, the importance of bringing our next generation of scientists up to speed on industrial applications is becoming much more important with the rapid, world-wide development of technology. FIAP is initiating a forum on entrepreneurship as a major role for the next generation of scientists. As physicists are problem solvers and the entrepreneurial experience is all about problem solving: whether involving technology, building a team, or financing a business. This forum seeks to link successful entrepreneurial physicists with the upcoming generation, through the dissemination of their global expertise and experience. The forum will consist of a panel discussion and then be open to question and answers from the audience.

Becoming a Physicist: The Roles of Research, Mindsets, and Milestones in Upper-Division Student Perceptions

ERIC Educational Resources Information Center

Irving, Paul W.; Sayre, Eleanor C.

2015-01-01

As part of a longitudinal study into identity development in upper-level physics students, we used a phenomenographic research method to examine students' perceptions of what it means to be a physicist. Analysis revealed six different categories of perception of what it means to be a physicist. We found the following themes: research and its…

Developing Technology Products - A Physicist's Perspective

NASA Astrophysics Data System (ADS)

Burka, Michael

2014-03-01

There are many physicists working in the industrial sector. We rarely have the word physicist in our job title; we are far more commonly called engineers or scientists. But, we are physicists, and we succeed because our training in physics has given us the habits of mind and the technical skills that one needs to solve complex technical challenges. This talk will explore the transition from physics research to technology product development using examples from my own career, first as a postdoctoral fellow and research scientist on the LIGO project, and then developing products in the spectroscopy, telecommunications, and medical device industries. Approaches to identifying and pursuing opportunities in industry will be discussed.

Moon-Mars Analogue Mission (EuroMoonMars 1 at the Mars Desert Research Station)

NASA Astrophysics Data System (ADS)

Lia Schlacht, Irene; Voute, Sara; Irwin, Stacy; Foing, Bernard H.; Stoker, Carol R.; Westenberg, Artemis

The Mars Desert Research Station (MDRS) is situated in an analogue habitat-based Martian environment, designed for missions to determine the knowledge and equipment necessary for successful future planetary exploration. For this purpose, a crew of six people worked and lived together in a closed-system environment. They performed habitability experiments within the dwelling and conducted Extra-Vehicular Activities (EVAs) for two weeks (20 Feb to 6 Mar 2010) and were guided externally by mission support, called "Earth" within the simulation. Crew 91, an international, mixed-gender, and multidisciplinary group, has completed several studies during the first mission of the EuroMoonMars campaign. The crew is composed of an Italian designer and human factors specialist, a Dutch geologist, an American physicist, and three French aerospace engineering students from Ecole de l'Air, all with ages between 21 and 31. Each crewmember worked on personal research and fulfilled a unique role within the group: commander, executive officer, engineer, health and safety officer, scientist, and journalist. The expedition focused on human factors, performance, communication, health and safety pro-tocols, and EVA procedures. The engineers' projects aimed to improve rover manoeuvrability, far-field communication, and data exchanges between the base and the rover or astronaut. The crew physicist evaluated dust control methods inside and outside the habitat. The geologist tested planetary geological sampling procedures. The crew designer investigated performance and overall habitability in the context of the Mars Habitability Experiment from the Extreme-Design group. During the mission the crew also participated in the Food Study and in the Ethospace study, managed by external groups. The poster will present crew dynamics, scientific results and daily schedule from a Human Factors perspective. Main co-sponsors and collaborators: ILEWG, ESA ESTEC, NASA Ames, Ecole de l'Air, SKOR, Extreme-Design, Universit` di Torino, MMS TU-Berlin, Space Florida, DAAD, Uni-a versity of Utrecht, The Mars Society.

Transits of Venus and Colonial India

NASA Astrophysics Data System (ADS)

Kochhar, Rajesh

2012-09-01

Astronomical expeditions during the colonial period had a political and national significance also. Measuring the earth and mapping the sky were activities worthy of powerful and power- seeking nations. Such was the sanctity of global astronomical activity that many other agendas could be hidden under it. An early astronomy-related expedition turned out to be extremely beneficial, to botany. The expedition sent by the French Government in 1735 to South America under the leadership of Charles Marie de la Condamine (1701--1774) ostensibly for the measurement of an arc of the meridian at Quito in Ecuador surreptitiously collected data that enabled Linnaeus to describe the genus cinchona in 1742. When the pair of transits of Venus occurred in 1761 and 1769, France and England were engaged in a bitter rivalry for control of India. The observation of the transits became a part of the rivalry. A telescope presented by the British to a South Indian King as a decorative toy was borrowed back for actual use. Scientifically the transit observations were a wash out, but the exercise introduced Europe to details of living Indian tradition of eclipse calculations. More significantly, it led to the institutionalization of modern astronomy in India under the auspices of the English East India Company (1787). The transits of Venus of 1874 and 1882 were important not so much for the study of the events as for initiating systematic photography of the Sun. By this, Britain owned most of the world's sunshine, and was expected to help European solar physicists get data from its vast Empire on a regular basis. This and the then genuinely held belief that a study of the sun would help predict failure of monsoons led to the institutionalization of solar physics studies in India (1899). Of course, when the solar physicists learnt that solar activity did not quite determine rainfall in India, they forgot to inform the Government.

Physicists for Human Rights in the Former Soviet Union

NASA Astrophysics Data System (ADS)

Chernyak, Yuri

2005-03-01

In his 1940 paper `Freedom and Science' Albert Einstein emphasized that ``intellectual independence is a primary necessity for the scientific inquirer'' and that ``political liberty is also extraordinarily important for his work.'' Raised in the tradition of intellectual independence and dedicated to the scientific truth, physicists were among the first to stand up for freedom in the USSR. It was no coincidence that the founders of the first independent Human Rights Committee (1970) were physicists: Andrei Sakharov, Valery Chalidze and Andrei Tverdokhlebov. In 1973 a physicist, Alexander Voronel, founded a Moscow Sunday (refusenik) Seminar -- the first openly independent scientific body in the history of the USSR. In 1976 physicists Andrei Sakharov, Yuri Orlov and a mathematician Natan Sharansky were the leading force in founding the famous Moscow Helsinki Human Rights Watch group. This talk briefly describes the special position of physicists (often viewed as Einstein's colleagues) in Soviet society, as well as their unique role in the struggle for human rights. It describes in some detail the Moscow Sunday Seminar, and extensions thereof such as International Conferences, the Computer School and the Computer Database of Refuseniks. The Soviet government considered such truly independent organizations as a challenge to Soviet authority and tried to destroy them. The Seminar's success and its very existence owed much to the support of Western scientific organizations, who persuaded their members to attend the Seminar and visit scientist-refuseniks. The human rights struggle led by physicists contributed substantially to the demise of the Soviet system.

Core curriculum for medical physicists in radiology. Recommendations from an EFOMP/ESR working group.

PubMed

Geleijns, Jacob; Breatnach, Eamann; Cantera, Alfonso Calzado; Damilakis, John; Dendy, Philip; Evans, Anthony; Faulkner, Keith; Padovani, Renato; Van Der Putten, Wil; Schad, Lothar; Wirestam, Ronnie; Eudaldo, Teresa

2012-06-01

Some years ago it was decided that a European curriculum should be developed for medical physicists professionally engaged in the support of clinical diagnostic imaging departments. With this in mind, EFOMP (European Federation of Organisations for Medical Physics) in association with ESR (European Society of Radiology) nominated an expert working group. This curriculum is now to hand. The curriculum is intended to promote best patient care in radiology departments through the harmonization of education and training of medical physicists to a high standard in diagnostic radiology. It is recommended that a medical physicist working in a radiology department should have an advanced level of professional expertise in X-ray imaging, and additionally, depending on local availability, should acquire knowledge and competencies in overseeing ultrasound imaging, nuclear medicine, and MRI technology. By demonstrating training to a standardized curriculum, medical physicists throughout Europe will enhance their mobility, while maintaining local high standards of medical physics expertise. This document also provides the basis for improved implementation of articles in the European medical exposure directives related to the medical physics expert. The curriculum is divided into three main sections: The first deals with general competencies in the principles of medical physics. The second section describes specific knowledge and skills required for a medical physicist (medical physics expert) to operate clinically in a department of diagnostic radiology. The final section outlines research skills that are also considered to be necessary and appropriate competencies in a career as medical physicist.

THE EDUCATION OF A PHYSICIST. AN ACCOUNT OF THE INTERNATIONAL CONFERENCE ON THE EDUCATION OF PROFESSIONAL PHYSICISTS, LONDON 15-21 JULY 1965.

ERIC Educational Resources Information Center

BROWN, SANBORN C.; CLARKE, NORMAN

CONTAINED IN THIS BOOK ARE INTERPRETATIONS OF PAPERS AND DISCUSSIONS PRESENTED AT THE "THIRD INTERNATIONAL CONFERENCE ON THE EDUCATION OF THE PROFESSIONAL PHYSICIST" WHICH WAS HELD IN LONDON IN JULY, 1965, AND WAS ATTENDED BY REPRESENTATIVES FROM 25 COUNTRIES. THE MATERIAL WAS EDITED, AND ORGANIZED TO STRESS THE ESSENTIAL DIFFERENCES IN…

The role, responsibilities and status of the clinical medical physicist in AFOMP.

PubMed

Ng, K H; Cheung, K Y; Hu, Y M; Inamura, K; Kim, H J; Krisanachinda, A; Leung, J; Pradhan, A S; Round, H; van Doomo, T; Wong, T J; Yi, B Y

2009-12-01

This document is the first of a series of policy statements being issued by the Asia-Oceania Federation of Organizations for Medical Physics (AFOMP). The document was developed by the AFOMP Professional Development Committee (PDC) and was endorsed for official release by AFOMP Council in 2006. The main purpose of the document was to give guidance to AFOMP member organizations on the role and responsibilities of clinical medical physicists. A definition of clinical medical physicist has also been provided. This document discusses the following topics: professional aspects of education and training; responsibilities of the clinical medical physicist; status and organization of the clinical medical physics service and the need for clinical medical physics service.

Report on the 4th International IUPAP Women in Physics Conference

NASA Astrophysics Data System (ADS)

Correa, Cynthia

2011-10-01

Stellenbosch, South Africa was the site of the 4^th International Union of Pure and Applied Physics (IUPAP) International Conference on Women in Physics, which took place on April 5^th-8^th. This conference brought together the diverse contributions of 250 female physicist attendees from nearly 60 countries worldwide to dissect the challenges faced by female physicists worldwide and to propose strategies to attract and retain more girls and women to the field. Having served as a member of the U.S. Delegation, I will discuss the resolutions reached and highlight the most important results of Global Survey of Physicists, where nearly 15,000 physicists shine light on how gender affects their lives and careers.

Solving a Problem by Using What You Know: A Physicist Looks at a Problem in Ecology

ERIC Educational Resources Information Center

Greenler, Robert

2015-01-01

Two philosophical ideas motivate this paper. The first is an answer to the question of what is an appropriate activity for a physicist. My answer is that an appropriate activity is anything where the tools of a physicist enable him or her to make a contribution to the solution of a significant problem. This may be obvious in areas that overlap…

``Physics and the girly girl—there is a contradiction somewhere'': doctoral students' positioning around discourses of gender and competence in physics

NASA Astrophysics Data System (ADS)

Gonsalves, Allison J.

2014-06-01

Doctoral physics students have stories about what kinds of actions, behaviours and ways of doing physics allow individuals to be recognized as physicists. Viewing a physics department as a case study, and individual participants as embedded cases, this study used a sociocultural approach to examine the ways doctoral students construct these stories about becoming physicists. Through observations, photo-elicitation, and life history interviews, eleven men and women shared stories about their experiences with physics, and the contexts that have enabled or constrained their trajectories into doctoral physics. The results of this study revealed the salience of recognition in the constitution of physicist identities; but how recognition was achieved often entailed the reproduction or reworking of persistent discourses of gender norms. Various interchangeable forms of competence (technical, analytical, and academic) emerged as assets that can be used to achieve recognition in this physics community. However, competence was not the only means by which one might be recognized as a physicist. Contributing to the possibility for recognition was the performance of stereotypical Discourses for physicist that relied on traditional gender norms for the field. The results demonstrated that achieving recognition as a competent physicist often involved a complex negotiation of gender roles and the practice of physics.

Radiotherapy and Nuclear Medicine Project for an Integral Oncology Center at the Oaxaca High Specialization Regional Hospital

NASA Astrophysics Data System (ADS)

De Jesús, M.; Trujillo-Zamudio, F. E.

2010-12-01

A building project of Radiotherapy & Nuclear Medicine services (diagnostic and therapy), within an Integral Oncology Center (IOC), requires interdisciplinary participation of architects, biomedical engineers, radiation oncologists and medical physicists. This report focus on the medical physicist role in designing, building and commissioning stages, for the final clinical use of an IOC at the Oaxaca High Specialization Regional Hospital (HRAEO). As a first step, during design stage, the medical physicist participates in discussions about radiation safety and regulatory requirements for the National Regulatory Agency (called CNSNS in Mexico). Medical physicists propose solutions to clinical needs and take decisions about installing medical equipment, in order to fulfill technical and medical requirements. As a second step, during the construction stage, medical physicists keep an eye on building materials and structural specifications. Meanwhile, regulatory documentation must be sent to CNSNS. This documentation compiles information about medical equipment, radioactivity facility, radiation workers and nuclear material data, in order to obtain the license for the linear accelerator, brachytherapy and nuclear medicine facilities. As a final step, after equipment installation, the commissioning stage takes place. As the conclusion, we show that medical physicists are essentials in order to fulfill with Mexican regulatory requirements in medical facilities.

MO-C-BRB-02: The Physicists’ Leadership Role in Academic Radiology: The Chair’s Perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arenson, R.

With the profound changes currently occurring in medicine, the role of the medical physicist cannot stagnate, but must evolve to meet the challenges and opportunities that are presented. Medical physicists must understand these changes and establish themselves not only as relevant but as leaders in this new environment. We must increase our presence in clinical settings such as tumor boards, patient rounds, and the development of new diagnosis, imaging, and treatment techniques. By establishing ourselves as competent scientists, we can and must participate in the development of technologies through research, teaching, and clinical implementation. As medical physicists we must definemore » our roles and value to our physician colleagues, patients, referring physicians, and senior administrators. We cannot afford to be viewed solely as quality assurance technologists, but need to move forward in step with medical and practice advances, becoming recognized as having a leadership role in providing quality research, technological development, and quality patient care. In this session, four leaders in medical research and healthcare will discuss their observations on how medical physicists have contributed to advancements in healthcare and opportunities to continue leadership in providing quality medicine through the applications of physics to research, education, and clinical practice. Learning Objectives: Understand the changes in the healthcare environment and how medical physicists can contribute to improving patient care. Learn how medical physicists are currently leading research efforts to improve clinical imaging and diagnosis. Understand the role of medical physicists in developing new technology and leading its translation into clinical care.« less

SU-F-P-13: NRG Oncology Medical Physics Manpower Survey Quantifying Support Demands for Multi Institutional Clinical Trials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Monroe, J; Case Western Reserve University; Boparai, K

Purpose: A survey was taken by NRG Oncology to assess Full Time Equivalent (FTE) contributions to multi institutional clinical trials by medical physicists.No current quantification of physicists’ efforts in FTE units associated with clinical trials is available. The complexity of multi-institutional trials increases with new technologies and techniques. Proper staffing may directly impact the quality of trial data and outcomes. The demands on physics time supporting clinical trials needs to be assessed. Methods: The NRG Oncology Medical Physicist Subcommittee created a sixteen question survey to obtain this FTE data. IROC Houston distributed the survey to their list of 1802 contactmore » physicists. Results: After three weeks, 363 responded (20.1% response). 187 (51.5%) institutions reporting external beam participation were processed. There was a wide range in number of protocols active and supported at each institution. Of the 187 clinics, 134 (71.7%) participate in 0 to 10 trials, 28 (15%) in 11 to 20 trials, 10 (5.3%) in 21 to 30 trials, 9 (4.8%) had 40 to 75 trials. On average, physicist spent 2.7 hours (SD: 6.0) per week supervising or interacting with clinical trial staff. 1.25 hours (SD: 3.37), 1.83 hours (SD: 4.13), and 0.64 hours(SD: 1.13) per week were spent on patient simulation, reviewing treatment plans, and maintaining a DICOM server, respectively. For all protocol credentialing activities, physicist spent an average of 37.05 hours (SD: 96.94) yearly. To support dosimetrists, clinicians, and therapists, physicist spend on average 2.07 hours (SD: 3.52) per week just reading protocols. Physicist attended clinical trial meetings for on average 1.13 hours (SD: 1.85) per month. Conclusion: Responding physicists spend a nontrivial amount of time: 8.8 hours per week (0.22 FTE) supporting, on average, 9 active multi-institutional clinical trials.« less

TU-F-BRD-01: Biomedical Informatics for Medical Physicists

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, M; Kalet, I; McNutt, T

Biomedical informatics encompasses a very large domain of knowledge and applications. This broad and loosely defined field can make it difficult to navigate. Physicists often are called upon to provide informatics services and/or to take part in projects involving principles of the field. The purpose of the presentations in this symposium is to help medical physicists gain some knowledge about the breadth of the field and how, in the current clinical and research environment, they can participate and contribute. Three talks have been designed to give an overview from the perspective of physicists and to provide a more in-depth discussionmore » in two areas. One of the primary purposes, and the main subject of the first talk, is to help physicists achieve a perspective about the range of the topics and concepts that fall under the heading of 'informatics'. The approach is to de-mystify topics and jargon and to help physicists find resources in the field should they need them. The other talks explore two areas of biomedical informatics in more depth. The goal is to highlight two domains of intense current interest--databases and models--in enough depth into current approaches so that an adequate background for independent inquiry is achieved. These two areas will serve as good examples of how physicists, using informatics principles, can contribute to oncology practice and research. Learning Objectives: To understand how the principles of biomedical informatics are used by medical physicists. To put the relevant informatics concepts in perspective with regard to biomedicine in general. To use clinical database design as an example of biomedical informatics. To provide a solid background into the problems and issues of the design and use of data and databases in radiation oncology. To use modeling in the service of decision support systems as an example of modeling methods and data use. To provide a background into how uncertainty in our data and knowledge can be incorporated into modeling methods.« less

Etiologies, clinical features and outcome of cardiac arrest in HIV-infected patients.

PubMed

Mongardon, Nicolas; Geri, Guillaume; Deye, Nicolas; Sonneville, Romain; Boissier, Florence; Perbet, Sébastien; Camous, Laurent; Lemiale, Virginie; Thirion, Marina; Mathonnet, Armelle; Argaud, Laurent; Bodson, Laurent; Gaudry, Stéphane; Kimmoun, Antoine; Legriel, Stéphane; Lerolle, Nicolas; Luis, David; Luyt, Charles-Edouard; Mayaux, Julien; Guidet, Bertrand; Pène, Frédéric; Mira, Jean-Paul; Cariou, Alain

2015-12-15

Compared to many other cardiovascular diseases, there is a paucity of data on the characteristics of successfully resuscitated cardiac arrest (CA) patients with human immunodeficiency virus (HIV) infection. We investigated causes, clinical features and outcome of these patients, and assessed the specific burden of HIV on outcome. Retrospective analysis of HIV-infected patients admitted to 20 French ICUs for successfully resuscitated CA (2000-2012). Characteristics and outcome of HIV-infected patients were compared to those of a large cohort of HIV-uninfected patients admitted after CA in the Cochin Hospital ICU during the same period. 99 patients were included (median CD4 lymphocyte count 233/mm(3), viral load 43 copies/ml). When compared with the control cohort of 1701 patients, HIV-infected patients were younger, with a predominance of male, a majority of in-hospital CA (52%), and non-shockable initial rhythm (80.8%). CA was mostly related to respiratory cause (n=36, including 23 pneumonia), cardiac cause (n=33, including 16 acute myocardial infarction), neurologic cause (n=8) and toxic cause (n=5). CA was deemed directly related to HIV infection in 18 cases. Seventy-one patients died in the ICU, mostly for care withdrawal after post-anoxic encephalopathy. After propensity score matching, ICU mortality was not significantly affected by HIV infection. Similarly, HIV disease characteristics had no impact on ICU outcome. Etiologies of CA in HIV-infected patients are miscellaneous and mostly not related to HIV infection. Outcome remains bleak but is similar to outcome of HIV-negative patients. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Benefit of immediate coronary angiography after out-of-hospital cardiac arrest in France: A nationwide propensity score analysis from the RéAC Registry.

PubMed

Jaeger, Déborah; Dumas, Florence; Escutnaire, Josephine; Sadoune, Sonia; Lauvray, Adrien; Elkhoury, Carlos; Bassand, Adrien; Girerd, Nicolas; Gueugniaud, Pierre Yves; Tazarourte, Karim; Hubert, Hervé; Cariou, Alain; Chouihed, Tahar

2018-05-01

The survival rate of out-of-hospital cardiac arrest (OHCA) remains extremely low, generally under 10%. Post-resuscitation care, and particularly early coronary reperfusion, may improve this outcome. The main objective of the present study was to determine whether patients with immediate coronary angiography at hospital admission (CAA) had a better outcome than patients without immediate CAA. This cohort analysis study was based on data extracted from the French National Cardiac Arrest registry (RéAC). To control for attribution bias, patients were matched using a propensity score, which included age clusters, low flow and no flow delays, initial rhythm and bystander cardiopulmonary resuscitation (CPR). The main endpoint was survival at day 30 (D30). Secondary endpoint was neurological recovery of survivors assessed by the Cerebral Performance Category (CPC) scale, with CPC 1 and 2 at D30 considered as a favorable outcome. From July 1st, 2011 to October 1st, 2016, 63394 OHCA were registered in the database, of which 39444 were of an unknown or suspected cardiac origin. After on-site resuscitation by a mobile medical team, 7584 patients were transported to a hospital facility. Among these patients, 4046 were retained in the analysis after matching for the aforementioned factors and constituted into 2 groups: immediate coronary angiography (iCAA) group (n = 2023) and non-immediate coronary angiography (niCAA) group (n = 2023). The survival rate at D30 after matching was 43.3% in the iCAA group versus 34.5% in the niCAA group (OD = 0.66 [0.58; 0.75], p < 0.001). In the iCAA group, (n = 707) 36% of the patients at D30 were CPC 1-2 comparatively to (n = 539) 27.3% in the niCAA group (p < 0.01). Both the survival and proportion of patients with favorable neurological recovery were significantly higher in patients who underwent an immediate coronary angiography after a resuscitated OHCA. These observational results warrant further exploration of the benefit of this invasive strategy in randomized studies. Copyright © 2018 Elsevier B.V. All rights reserved.

Transcriptome analysis of PCOS arrested 2-cell embryos.

PubMed

Lu, Cuiling; Chi, Hongbin; Wang, Yapeng; Feng, Xue; Wang, Lina; Huang, Shuo; Yan, Liying; Lin, Shengli; Liu, Ping; Qiao, Jie

2018-06-18

In an attempt to explore the early developmental arrest in embryos from polycystic ovarian syndrome (PCOS) patients, we sequenced the transcriptome profiles of PCOS arrested 2-cell embryos, non-PCOS arrested 2-cell embryos and non-arrested 2-cell embryos using single-cell RNA-Seq technique. Differential expression analysis was performed using the DEGSeq R package. Gene Ontology (GO) enrichment was analyzed using the GOseq R package. Data revealed 62 differentially expressed genes between non-PCOS arrested and PCOS arrested embryos and 2217 differentially expressed genes between PCOS arrested and non-arrested 2-cell embryos. A total of 49 differently expressed genes (DEGs) were annotated with GO terms in the up-regulated genes between PCOS arrested and non-PCOS arrested embryos after GO enrichment. A total of 29 DEGs were annotated with GO terms in the down-regulated genes between PCOS arrested and non-arrested 2-cell embryos after GO enrichment. These data can provide a reference for screening specific genes involved in the arrest of PCOS embryos.

Stretched exponential distributions in nature and economy: ``fat tails'' with characteristic scales

NASA Astrophysics Data System (ADS)

Laherrère, J.; Sornette, D.

1998-04-01

To account quantitatively for many reported "natural" fat tail distributions in Nature and Economy, we propose the stretched exponential family as a complement to the often used power law distributions. It has many advantages, among which to be economical with only two adjustable parameters with clear physical interpretation. Furthermore, it derives from a simple and generic mechanism in terms of multiplicative processes. We show that stretched exponentials describe very well the distributions of radio and light emissions from galaxies, of US GOM OCS oilfield reserve sizes, of World, US and French agglomeration sizes, of country population sizes, of daily Forex US-Mark and Franc-Mark price variations, of Vostok (near the south pole) temperature variations over the last 400 000 years, of the Raup-Sepkoski's kill curve and of citations of the most cited physicists in the world. We also discuss its potential for the distribution of earthquake sizes and fault displacements. We suggest physical interpretations of the parameters and provide a short toolkit of the statistical properties of the stretched exponentials. We also provide a comparison with other distributions, such as the shifted linear fractal, the log-normal and the recently introduced parabolic fractal distributions.

Making sense of absolute measurement: James Clerk Maxwell, William Thomson, Fleeming Jenkin, and the invention of the dimensional formula

NASA Astrophysics Data System (ADS)

Mitchell, Daniel Jon

2017-05-01

During the 1860s, the Committee on Electrical Standards convened by the British Association for the Advancement of Science (BAAS) attempted to articulate, refine, and realize a system of absolute electrical measurement. I describe how this context led to the invention of the dimensional formula by James Clerk Maxwell and subsequently shaped its interpretation, in particular through the attempts of William Thomson and Fleeming Jenkin to make absolute electrical measurement intelligible to telegraph engineers. I identify unit conversion as the canonical purpose for dimensional formulae during the remainder of the nineteenth century and go on to explain how an operational interpretation was developed by the French physicist Gabriel Lippmann. The focus on the dimensional formula reveals how various conceptual, theoretical, and material aspects of absolute electrical measurement were taken up or resisted in experimental physics, telegraphic engineering, and electrical practice more broadly, which leads to the conclusion that the integration of electrical theory and telegraphic practice was far harder to achieve and maintain than historians have previously thought. This ultimately left a confusing legacy of dimensional concepts and practices in physics.

Spectacular Layers Exposed in Becquerel Crater

NASA Technical Reports Server (NTRS)

2001-01-01

Toward the end of its Primary Mapping Mission, the Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) acquired one of its most spectacular pictures of layered sedimentary rock exposed within the ancient crater Becquerel. Pictures such as this one from January 25, 2001, underscore the fact that you never know from one day to the next what the next MOC images will uncover. While the Primary Mission ends January 31, 2001, thousands of new pictures--revealing as-yet-unseen terrain on the red planet--may be obtained during the Extended Mission phase, scheduled to run through at least April 2002.

The picture shown here reveals hundreds of light-toned layers in the 167 kilometers (104 miles) wide basin named for 19th Century French physicist Antoine H. Becquerel (1852-1908). These layers are interpreted to be sedimentary rocks deposited in the crater at some time in the distant past. They have since been eroded and exposed, revealing faults, dark layers between the bright layers, and a long geologic history (of unknown duration) recorded in these materials. Sets of parallel faults can be seen cutting across the layers in the left third of the image. Sunlight illuminates this scene from the top/upper right.

SU-F-T-250: What Does It Take to Correctly Assess the High Failure Modes of an Advanced Radiotherapy Procedure Such as Stereotactic Body Radiation Therapy?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Han, D; Vile, D; Rosu, M

Purpose: Assess the correct implementation of risk-based methodology of TG 100 to optimize quality management and patient safety procedures for Stereotactic Body Radiation Therapy. Methods: A detailed process map of SBRT treatment procedure was generated by a team of three physicists with varying clinical experience at our institution to assess the potential high-risk failure modes. The probabilities of occurrence (O), severity (S) and detectability (D) for potential failure mode in each step of the process map were assigned by these individuals independently on the scale from1 to 10. The risk priority numbers (RPN) were computed and analyzed. The highest 30more » potential modes from each physicist’s analysis were then compared. Results: The RPN values assessed by the three physicists ranged from 30 to 300. The magnitudes of the RPN values from each physicist were different, and there was no concordance in the highest RPN values recorded by three physicists independently. The 10 highest RPN values belonged to sub steps of CT simulation, contouring and delivery in the SBRT process map. For these 10 highest RPN values, at least two physicists, irrespective of their length of experience had concordance but no general conclusions emerged. Conclusion: This study clearly shows that the risk-based assessment of a clinical process map requires great deal of preparation, group discussions, and participation by all stakeholders. One group albeit physicists cannot effectively implement risk-based methodology proposed by TG100. It should be a team effort in which the physicists can certainly play the leading role. This also corroborates TG100 recommendation that risk-based assessment of clinical processes is a multidisciplinary team effort.« less

MO-DE-304-01: The Abt Study of Medical Physicist Work Values for Radiation Oncology Physics Services: Round IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mills, M.

The Abt study of medical physicist work values for radiation oncology physics services, Round IV is completed. It supersedes the Abt III study of 2008. The 2015 Abt study measured qualified medical physicist (QMP) work associated with routine radiation oncology procedures as well as some special procedures. As before, a work model was created to allow the medical physicist to defend QMP work based on both routine and special procedures service mix. The work model can be used to develop a cost justification report for setting charges for radiation oncology physics services. The Abt study Round IV was designed tomore » empower the medical physicist to negotiate a service or employment contract with providers based on measured national QMP workforce and staffing data. For a variety of reasons, the diagnostic imaging contingent of AAPM has had a more difficult time trying estimate workforce requirements than their therapy counterparts. Over the past several years, the Diagnostic Work and Workforce Study Subcommittee (DWWSS) has collected survey data from AAPM members, but the data have been very difficult to interpret. The DWWSS has reached out to include more AAPM volunteers to create a more full and accurate representation of actual clinical practice models on the subcommittee. Though much work remains, through hours of discussion and brainstorming, the DWWSS has somewhat of a clear path forward. This talk will provide attendees with an update on the efforts of the subcommittee. Learning Objectives: Understand the new information documented in the Abt studies. Understand how to use the Abt studies to justify medical physicist staffing. Learn relevant historical information on imaging physicist workforce. Understand the process of the DWWSS in 2014. Understand the intended path forward for the DWWSS.« less

Book Review: The genius of science: a portrait gallery of twentieth-century physicists. Abraham Pais, Oxford University Press, New York, 2000, 365 pp., UK £26.50, ISBN 0-19-850614-7

NASA Astrophysics Data System (ADS)

Kragh, Helge

Abraham Pais made important contributions to the physics of elementary particles and other areas of theoretical physics before he turned, in the 1970s, to the history of modern physics, a field he cultivated energetically and successfully until his death in 2000. Among the best works of the prolific physicist-historian (a better term, in this case, than historian of physics) is the acclaimed Einstein biography Subtle is the Lord (1982) and Inward Bound (1986), a comprehensive chronicle of elementary particle physics. More recently his autobiography, A Tale of Two Continents (1997), appeared, a book to a large extent based on Pais's friendship and acquaintance with many of the greatest physicists of the twentieth century. In the present book, the physicists who appeared as supporting cast in his autobiography are presented in their own right, chapter by chapter. Yet Pais himself is present throughout the book and the reader is constantly reminded of his friendship with the physicists portrayed.

Converting Radiology Operations in a Six-Hospital Healthcare System from Film-Based to Digital: Another Leadership Role for the Diagnostic Medical Physicist

NASA Astrophysics Data System (ADS)

Arreola, Manuel M.; Rill, Lynn N.

2004-09-01

As medical facilities across the United States continue to convert their radiology operations from film-based to digital environments, partially accomplished and failed endeavors are frequent because of the lack of competent and knowledgeable leadership. The diagnostic medical physicist is, without a doubt, in a privileged position to take such a leadership role, not only because of her/his understanding of the basics principles of new imaging modalities, but also because of her/his inherent participation in workflow design and educational/training activities. A well-structured approach by the physicist will certainly lead the project to a successful completion, opening, in turn, new opportunities for the medical physicist to become an active participant in the decision-making process for an institution.

A survey of Canadian medical physicists: software quality assurance of in-house software.

PubMed

Salomons, Greg J; Kelly, Diane

2015-01-05

This paper reports on a survey of medical physicists who write and use in-house written software as part of their professional work. The goal of the survey was to assess the extent of in-house software usage and the desire or need for related software quality guidelines. The survey contained eight multiple-choice questions, a ranking question, and seven free text questions. The survey was sent to medical physicists associated with cancer centers across Canada. The respondents to the survey expressed interest in having guidelines to help them in their software-related work, but also demonstrated extensive skills in the area of testing, safety, and communication. These existing skills form a basis for medical physicists to establish a set of software quality guidelines.

Careers and people

NASA Astrophysics Data System (ADS)

2009-02-01

Early-career scientists honoured Nine physicists were among 67 US-based researchers to be awarded a Presidential Early Career Award for Scientists and Engineers at a White House ceremony in late December 2008. The award comes with up to five years' funding for research deemed critical to government missions. This year's winners include nuclear physicist Mickey Chiu and particle physicist Hooman Davoudiasl, both of the Brookhaven National Laboratory; biophysicist Michael Elowitz of the California Institute of Technology; Chad Fertig, an atomic physicist at the University of Georgia; astronomer Charles Kankelborg of Montana State University; astrophysicist Merav Opher of George Mason University; theorist Robin Santra of the Argonne National Laboratory; quantum-computing researcher Raymond Simmons of the National Institute of Standards and Technologies in Boulder, Colorado; and string theorist Anastasia Volovich of Brown University.

Impacts of reforestation and gravel mining on the Malnant River, Haute-Savoie, French Alps

NASA Astrophysics Data System (ADS)

Marston, Richard A.; Bravard, Jean-Paul; Green, Tim

2003-09-01

The Malnant River is a rapidly incising river with a French name that translates as "bad creek," reflecting local opinion of the hazards from dramatic channel changes that have occurred in the last few centuries. Downcutting in the last three decades has created severe problems for farmers in this small watershed (16 km 2) as bridges are undermined, streamside roads are threatened, and irrigation diversion structures are rendered unusable. The purpose of our study was to determine the extent and causes of downcutting. A detailed landcover map dated 1732 revealed that forest cover had been reduced by that time to 10% of the present-day cover. The Malnant was strongly affected by floods and debris torrents during the 18th and 19th centuries that delivered massive amounts of sediment. During the 20th century, reforestation reduced the sediment delivery from hillslopes. In addition, gravel extraction in the Malnant and in the Fier River (of which the Malnant is a tributary) has lowered the base level for the river. This initiated a knickpoint that moved upstream. Weirs placed in the Malnant in 1968 were used to measure rates of bed incision in the field. With a mean width of 4.0 m and degradation up to 36 cubic meters per meter channel length, the lower 4.5 km of the Malnant has experienced a net loss of approximately 163,000 m 3 of bed material. Above the 4.5-km point on the Malnant, bedrock controls exist that have arrested the upstream-progressing degradation.

Children detained in French police cells.

PubMed

Fablet, Dorothée; Chariot, Patrick

2018-02-14

Police custody is detention in response to a suspicion of crime. In France, until the age of 13, pre-trial detention and police custody are not allowed. We aimed to evaluate the practical implementation of police detention of children aged between 10 and 12 years and describe the medical characteristics and history, perceived health status and opinion on custody of the potentially affected children. A descriptive study was conducted in a French reference regional department of forensic medicine at the time of medical examination in police cells among arrestees younger than 13 years old examined over a 5-year period (1 January 2011-31 December 2015). Children aged 10-12 years (n = 60; males, 48, 80%), accounting for 60 of 57 687 examined arrestees (0.1%), were examined over the study period. Six individuals (10%) were arrested twice or more times during the study period (for a total of 76 detentions analysed). The most common suspected crimes were theft or robbery (42/76, 55%) and physical assault (22/76, 29%). Arrestees had a favourable opinion of custody in 33 of 76 cases (43%). Children reported physical assault by the police in 6 of 76 cases (8%), and the physicians observed recent traumatic injuries in 7 of 76 cases (9%). Daily tobacco consumption was reported by 4 of 60 children (7%). No child was considered unfit for detention by the physician. Children aged 10-12 years suspected of serious crimes accounted for 0.1% of detained individuals in police cells. Although infrequent, such situations are a matter of concern. © 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

Women Physicists Speak Again

NASA Astrophysics Data System (ADS)

Ivie, Rachel; Guo, Stacy

2005-10-01

More than 1350 women physicists from more than 70 countries responded to a survey designed to identify issues important to women in physics. Women physicists had many areas of concern, notably discrimination and career/family balance. However, they also had many successes in physics. The majority would choose physics again and felt that they had progressed in their careers at least as quickly as their colleagues. Many spoke eloquently about their love of physics, the support they had received from others, and about their own determination and hard work.

Belarusian female physicists: Statistics and perspectives

NASA Astrophysics Data System (ADS)

Fedotova, Julia; Tashlykova-Bushkevich, Iya

2013-03-01

The experience for women in physics remains challenging in Belarus. The proportion of female physics master's degree recipients is approximately 30%, while the percentage of female physics PhD recipients is 50%. Still, only a few female physicists occupy top positions in research laboratories, institutes, or universities. The basic problem for career-oriented female physicists in Belarus is public opinion, which cultivates a passive and dependent life philosophy for women. The Belarusian Women in Physics group was formed in 2003 as part of the Belarusian Physical Society.

Fireworks on the 4th of July

NASA Astrophysics Data System (ADS)

Barnett, R. Michael

2013-02-01

After half a century of waiting, the drama was intense. Physicists slept overnight outside the auditorium to get seats for the seminar at the CERN lab in Geneva, Switzerland. Ten thousand miles away on the other side of the planet, at the world's most prestigious international particle physics conference, hundreds of physicists from every corner of the globe lined up to hear the seminar streamed live from Geneva (see Fig. 1). And in universities from North America to Asia, physicists and students gathered to watch the streaming talks.

Early Jet Engines and the Transition from Centrifugal to Axial Compressors: A Case Study in Technological Change

DTIC Science & Technology

1988-01-01

report, prepared by physicist Edgar Buckingham in 1922, did not encourage further development of the concept. 3 1 But Buckingham did not actually...because Buckingham , an able physicist, treated the problem as well-defined, as is usual in solving a scientific problem. Buckingham was not a...But Buckingham did not have the same purpose in mind as those later inventors. Buckingham the physicist did not ask the same questions as Whittle

Fear rises among Iranian physicists

NASA Astrophysics Data System (ADS)

Dacey, James

2011-01-01

Academics in Iran have been left in a state of fear following the murder in Tehran last November of nuclear physicist Majid Shahriari and the attempted assassination of another nuclear researcher, Fereydoon Abbasi.

ECPR for Refractory Out-Of-Hospital Cardiac Arrest

ClinicalTrials.gov

2018-05-09

Cardiac Arrest; Heart Arrest; Sudden Cardiac Arrest; Cardiopulmonary Arrest; Death, Sudden, Cardiac; Cardiopulmonary Resuscitation; CPR; Extracorporeal Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation

Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology.

PubMed

Uray, Thomas; Lamade, Andrew; Elmer, Jonathan; Drabek, Tomas; Stezoski, Jason P; Missé, Amalea; Janesko-Feldman, Keri; Garman, Robert H; Chen, Niel; Kochanek, Patrick M; Dezfulian, Cameron; Callaway, Clifton W; Doshi, Ankur A; Frisch, Adam; Guyette, Francis X; Reynolds, Josh C; Rittenberger, Jon C

2018-06-01

Cardiac arrest etiology may be an important source of between-patient heterogeneity, but the impact of etiology on organ injury is unknown. We tested the hypothesis that asphyxial cardiac arrest results in greater neurologic injury than cardiac etiology cardiac arrest (ventricular fibrillation cardiac arrest), whereas ventricular fibrillation cardiac arrest results in greater cardiovascular dysfunction after return of spontaneous circulation. Prospective observational human and randomized animal study. University laboratory and ICUs. Five-hundred forty-three cardiac arrest patients admitted to ICU. Seventy-five male Sprague-Dawley rats. We examined neurologic and cardiovascular injury in Isoflurane-anesthetized rat cardiac arrest models matched by ischemic time. Hemodynamic and neurologic outcomes were assessed after 5 minutes no flow asphyxial cardiac arrest or ventricular fibrillation cardiac arrest. Comparison was made to injury patterns observed after human asphyxial cardiac arrest or ventricular fibrillation cardiac arrest. In rats, cardiac output (20 ± 10 vs 45 ± 9 mL/min) and pH were lower and lactate higher (9.5 ± 1.0 vs 6.4 ± 1.3 mmol/L) after return of spontaneous circulation from ventricular fibrillation cardiac arrest versus asphyxial cardiac arrest (all p < 0.01). Asphyxial cardiac arrest resulted in greater early neurologic deficits, 7-day neuronal loss, and reduced freezing time (memory) after conditioned fear (all p < 0.05). Brain antioxidant reserves were more depleted following asphyxial cardiac arrest. In adjusted analyses, human ventricular fibrillation cardiac arrest was associated with greater cardiovascular injury based on peak troponin (7.8 ng/mL [0.8-57 ng/mL] vs 0.3 ng/mL [0.0-1.5 ng/mL]) and ejection fraction by echocardiography (20% vs 55%; all p < 0.0001), whereas asphyxial cardiac arrest was associated with worse early neurologic injury and poor functional outcome at hospital discharge (n = 46 [18%] vs 102 [44%]; p < 0.0001). Most ventricular fibrillation cardiac arrest deaths (54%) were the result of cardiovascular instability, whereas most asphyxial cardiac arrest deaths (75%) resulted from neurologic injury (p < 0.0001). In transcending rat and human studies, we find a consistent phenotype of heart and brain injury after cardiac arrest based on etiology: ventricular fibrillation cardiac arrest produces worse cardiovascular dysfunction, whereas asphyxial cardiac arrest produces worsened neurologic injury associated with greater oxidative stress.

What physicists should learn about finance (if they want to)

NASA Astrophysics Data System (ADS)

Schmidt, Anatoly

2006-03-01

There has been growing interest among physicists to Econophysics, i.e. analysis and modeling of financial and economic processes using the concepts of theoretical Physics. There has been also perception that the financial industry is a viable alternative for those physicists who are not able or are not willing to pursue career in their major field. However in our times, the Wall Street expects from applicants for quantitative positions not only the knowledge of the stochastic calculus and the methods of time series analysis but also of such concepts as option pricing, portfolio management, and risk measurement. Here I describe a synthetic course based on my book ``Quantitative Finance for Physicists'' (Elsevier, 2004) that outlines both worlds: Econophysics and Mathematical Finance. This course may be offered as elective for senior undergraduate or graduate Physics majors.

WE-G-19A-01: Radiologists and Medical Physicists: Working Together to Achieve Common Goals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, A; Ma, J; Steele, J

It is vitally important that medical physicists understand the clinical questions that radiologists are trying to answer with patient images. Knowledge of the types of information the radiologist needs helps medical physicists configure imaging protocols that appropriately balance radiation dose, time, and image quality. The ability to communicate with radiologists and understand medical terminology, anatomy, and physiology is key to creating such imaging protocols. In this session, radiologists will present clinical cases and describe the information they are seeking in the clinical images. Medical physicists will then discuss how imaging protocols are configured. Learning Objectives: Understand the types of informationmore » that radiologists seek in medical images. Apply this understanding in configuring the imaging equipment to deliver this information. Develop strategies for working with physician colleagues.« less

A survey of Canadian medical physicists: software quality assurance of in‐house software

PubMed Central

Kelly, Diane

2015-01-01

This paper reports on a survey of medical physicists who write and use in‐house written software as part of their professional work. The goal of the survey was to assess the extent of in‐house software usage and the desire or need for related software quality guidelines. The survey contained eight multiple‐choice questions, a ranking question, and seven free text questions. The survey was sent to medical physicists associated with cancer centers across Canada. The respondents to the survey expressed interest in having guidelines to help them in their software‐related work, but also demonstrated extensive skills in the area of testing, safety, and communication. These existing skills form a basis for medical physicists to establish a set of software quality guidelines. PACS number: 87.55.Qr PMID:25679168

SU-B-213-03: Evaluation of Graduate Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, B.

2015-06-15

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

SU-B-213-04: Evaluation of Residency Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reft, C.

2015-06-15

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

SU-B-213-06: Development of ABR Examination Questions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allison, J.

2015-06-15

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

SU-B-213-02: Development of CAMPEP Standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beckham, W.

2015-06-15

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

SU-B-213-01: Introduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Starkschall, G.

2015-06-15

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

SU-B-213-07: Panel Discussion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Starkschall, G.

2015-06-15

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

Physics, Physicists and Revolutionary Capabilities for the Intelligence Community

NASA Astrophysics Data System (ADS)

Porter, Lisa

2009-05-01

Over the past several decades, physicists have made seminal contributions to technological capabilities that have enabled the U.S. intelligence community to provide unexpected and unparalleled information to our nation's decision makers and help dispel the cloud of uncertainty they face in dealing with crises and challenges around the world. As we look to the future, we recognize that the ever-quickening pace of changes in the world and the threats we must confront demand continued innovation and improvement in the capabilities needed to provide the information on which our leaders depend. This talk will focus on some of the major technological challenges that the intelligence community faces in the coming years, and the many ways that physicists can help to overcome those challenges. The potential impact of physicists on the future capabilities of the US intelligence community is huge. In addition to the more obvious and direct impact through research in areas ranging from novel sensors to quantum information science, the unique approach physicists bring to a problem can also have an indirect but important effect by influencing how challenges in areas ranging from cybersecurity to advanced analytics are approached and solved. Several examples will be given.

Medical physics is alive and well and growing in South East Asia.

PubMed

Ng, K; Pirabul, R; Peralta, A; Soejoko, D

1997-03-01

In recent years there has been a significant economic growth in South East Asia, along with it a concurrent development of medical physics. The status of four countries--Malaysia, Thailand, the Philippines and Indonesia are presented. Medical physicists in these countries have been experiencing the usual problems of lack of recognition, low salaries, and insufficient facilities for education and training opportunities. However the situation has improved recently through the initiative of local enthusiastic medical physicists who have started MS graduate programs in medical physics and begun organizing professional activities to raise the profile of medical physics. The tremendous support and catalytic roles of the American Association of Physicists in Medicine (AAPM) and international organizations such as International Organization for Medical Physics (IOMP), International Atomic Energy Agency (IAEA), World Health Organization (WHO), and International Center for Theoretical Physics (ICTP) have been instrumental in achieving progress. Contributions by these organizations include co-sponsorship of workshops and conferences, travel grants, medical physics libraries programs, and providing experts and educators. The demand for medical physicists is expected to rise in tandem with the increased emphasis on innovative technology for health care, stringent governmental regulation, and acceptance by the medical community of the important role of medical physicists.

SU-B-213-05: Development of ABR Certification Standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seibert, J.

2015-06-15

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

Engaging Cuban Physicists Through the APS/CPS Partnership

NASA Astrophysics Data System (ADS)

Lerch, Irving A.; Lerch, Irving A.

In his reflections on Cuban physics, Marcelo Alonso urges APS to take steps to promote interactions between Cuban and US physicists. As an introduction to Marcello's essay, this note will summarize past and current activities.

Epidemiology and Outcomes After In-Hospital Cardiac Arrest After Pediatric Cardiac Surgery

PubMed Central

Gupta, Punkaj; Jacobs, Jeffrey P.; Pasquali, Sara K.; Hill, Kevin D.; Gaynor, J. William; O’Brien, Sean M.; He, Max; Sheng, Shubin; Schexnayder, Stephen M.; Berg, Robert A.; Nadkarni, Vinay M.; Imamura, Michiaki; Jacobs, Marshall L.

2014-01-01

Background Multicenter data regarding cardiac arrest in children undergoing heart operations are limited. We describe epidemiology and outcomes associated with postoperative cardiac arrest in a large multiinstitutional cohort. Methods Patients younger than 18 years in the Society of Thoracic Surgeons Congenital Heart Surgery Database (2007 through 2012) were included. Patient factors, operative characteristics, and outcomes were described for patients with and without postoperative cardiac arrest. Multivariable models were used to evaluate the association of center volume with cardiac arrest rate and mortality after cardiac arrest, adjusting for patient and procedural factors. Results Of 70,270 patients (97 centers), 1,843 (2.6%) had postoperative cardiac arrest. Younger age, lower weight, and presence of preoperative morbidities (all p < 0.0001) were associated with cardiac arrest. Arrest rate increased with procedural complexity across common benchmark operations, ranging from 0.7% (ventricular septal defect repair) to 12.7% (Norwood operation). Cardiac arrest was associated with significant mortality risk across procedures, ranging from 15.4% to 62.3% (all p < 0.0001). In multivariable analysis, arrest rate was not associated with center volume (odds ratio, 1.06; 95% confidence interval, 0.71 to 1.57 in low- versus high-volume centers). However, mortality after cardiac arrest was higher in low-volume centers (odds ratio, 2.00; 95% confidence interval, 1.52 to 2.63). This association was present for both high- and low-complexity operations. Conclusions Cardiac arrest carries a significant mortality risk across the stratum of procedural complexity. Although arrest rates are not associated with center volume, lower-volume centers have increased mortality after cardiac arrest. Further study of mechanisms to prevent cardiac arrest and to reduce mortality in those with an arrest is warranted. PMID:25443018

A day with the women physicists of Pakistan

NASA Astrophysics Data System (ADS)

Hasnain, Aziz Fatima; Islam, Aquila; Ali, Asima; Qureshi, Riffat Mehmood; Qamar, Anisa

2015-12-01

The Working Group on Women in Physics successfully organized a national-level meeting of women physicists at the National Centre for Physics, Quaid-e-Azam University, to discuss the agenda for the 5th IUPAP International Conference on Women in Physics. This report describes the outcome of the meeting and the status of female physicists in Pakistan. It also includes a comparative study of the enrollment of women in undergraduate and graduate programs in physics, along with a brief description of factors that create hurdles for female students opting for higher education in this field.

Programming (Tips) for Physicists & Engineers

ScienceCinema

Ozcan, Erkcan

2018-02-19

Programming for today's physicists and engineers. Work environment: today's astroparticle, accelerator experiments and information industry rely on large collaborations. Need more than ever: code sharing/resuse, code building--framework integration, documentation and good visualization, working remotely, not reinventing the wheel.

Will new gender policies stop the decrease of women physicists in Portugal?

NASA Astrophysics Data System (ADS)

Rosa, Carla Carmelo; Peña, Maria Teresa; Saavedra, Luisa; Providência, Constança

2013-03-01

The present context of women physicists in Portugal is discussed, updating our report for the 2002 IUPAP International Conference on Women in Physics, in which the 30 years prior to 2000 were analyzed.

Programming (Tips) for Physicists & Engineers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozcan, Erkcan

2010-07-13

Programming for today's physicists and engineers. Work environment: today's astroparticle, accelerator experiments and information industry rely on large collaborations. Need more than ever: code sharing/resuse, code building--framework integration, documentation and good visualization, working remotely, not reinventing the wheel.

Analysis of recurrent patterns in toroidal magnetic fields.

PubMed

Sanderson, Allen R; Chen, Guoning; Tricoche, Xavier; Pugmire, David; Kruger, Scott; Breslau, Joshua

2010-01-01

In the development of magnetic confinement fusion which will potentially be a future source for low cost power, physicists must be able to analyze the magnetic field that confines the burning plasma. While the magnetic field can be described as a vector field, traditional techniques for analyzing the field's topology cannot be used because of its Hamiltonian nature. In this paper we describe a technique developed as a collaboration between physicists and computer scientists that determines the topology of a toroidal magnetic field using fieldlines with near minimal lengths. More specifically, we analyze the Poincaré map of the sampled fieldlines in a Poincaré section including identifying critical points and other topological features of interest to physicists. The technique has been deployed into an interactive parallel visualization tool which physicists are using to gain new insight into simulations of magnetically confined burning plasmas.

Dr. Inside and Dr. Outside: Physicists Involved With National Security and Foreign Policy

NASA Astrophysics Data System (ADS)

Zimmerman, Peter D.

2009-05-01

Physicists have had a special interest in American national security and arms control since at least the Manhattan Project. They have served our country in uniform and in the career civil service. Some have left academic careers for brief periods to work as political appointees, consultants, or resident scholars and then returned to an academic life, but often with changed goals. Some have tried government life and left nearly immediately, while others dipped a toe in and decided to stay. I will look at real-life examples, mostly using real names, drawn from my career and circle of colleagues to try to explain why some physicists have been extremely successful, why others have not, and what happens to a physicist who moved to Washington and decides to stay. I will also discuss routes into public service for those interesting in giving it a try.

The Mental Aftermath - The Mentality of German Physicists 1945-1949

NASA Astrophysics Data System (ADS)

Hentschel, Klaus

2007-01-01

Few scientific communities have been more thoroughly studied than 20th-century German physicists. Yet their behavior and patterns of thinking immediately after the war remains puzzling. During the first five postwar years they suspended their internecine battles and a strange solidarity emerged. Former enemies were suddenly willing to exonerate each other blindly and even morally upright physicists began to write tirades against the 'denazification mischief' or the 'export of scientists'. Personal idiosyncracies melded into a strangely uniform pattern of rejection or resistance to the Allied occupiers, with attendant repressed feelings and self-pity. Politics was once again perceived as remote, dirty business. It was feared that the least concession of guilt would bring down even more severe sanctions on their discipline. Using tools from the history of mentality, such as analysis of serial publications, these tendenciesare examined. The perspective of emigre physicists, as reflected in their private letters and reports, embellish this portrait.

Temporal patterns of change in vital signs and Cardiac Arrest Risk Triage scores over the 48 hours preceding fatal in-hospital cardiac arrest.

PubMed

Oh, HyunSoo; Lee, KangIm; Seo, WhaSook

2016-05-01

To determine temporal patterns of vital sign and Cardiac Arrest Risk Triage score changes over the 48-hour period preceding cardiac arrest in an ICU setting. Vital sign instability usually occurs prior to cardiac arrest. However, few studies have been conducted on the temporal patterns of individual vital signs preceding cardiac arrest. A retrospective case-control study. The study subjects were 140 ICU patients (1 June 2011-31 December 2012): 46 died of cardiac arrest (case group), 45 died of other illnesses (control I group) and 49 were discharged after recovering (control II group). Initial detectable changes in blood pressure appeared 18-20 hours and became dramatic at 5-10 hours before cardiac arrest. Noticeable changes in heart rates began at 4 hours and became more prominent at 2 hours pre-arrest. No apparent patterns in respiratory rate changes were observed. Body temperatures usually indicated a hypothermic state pre-arrest. Cardiac Arrest Risk Triage scores were 16-18 at 48 hours pre-arrest and then continuously increased to 20. Only mean values of systolic blood pressures were significantly different between the three study groups. Mean diastolic blood pressures, heart rates, respiratory rates and Cardiac Arrest Risk Triage scores differed between the case and control II groups and between the control I and II groups. The study demonstrates vital sign instability preceded cardiac arrest and that the temporal patterns of changes in individual vital signs and Cardiac Arrest Risk Triage scores differed between groups. The findings of this study may aid the development of management strategies for cardiac arrest. © 2016 John Wiley & Sons Ltd.

SU-E-T-635: Process Mapping of Eye Plaque Brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huynh, J; Kim, Y

Purpose: To apply a risk-based assessment and analysis technique (AAPM TG 100) to eye plaque brachytherapy treatment of ocular melanoma. Methods: The role and responsibility of personnel involved in the eye plaque brachytherapy is defined for retinal specialist, radiation oncologist, nurse and medical physicist. The entire procedure was examined carefully. First, major processes were identified and then details for each major process were followed. Results: Seventy-one total potential modes were identified. Eight major processes (corresponding detailed number of modes) are patient consultation (2 modes), pretreatment tumor localization (11), treatment planning (13), seed ordering and calibration (10), eye plaque assembly (10),more » implantation (11), removal (11), and deconstruction (3), respectively. Half of the total modes (36 modes) are related to physicist while physicist is not involved in processes such as during the actual procedure of suturing and removing the plaque. Conclusion: Not only can failure modes arise from physicist-related procedures such as treatment planning and source activity calibration, but it can also exist in more clinical procedures by other medical staff. The improvement of the accurate communication for non-physicist-related clinical procedures could potentially be an approach to prevent human errors. More rigorous physics double check would reduce the error for physicist-related procedures. Eventually, based on this detailed process map, failure mode and effect analysis (FMEA) will identify top tiers of modes by ranking all possible modes with risk priority number (RPN). For those high risk modes, fault tree analysis (FTA) will provide possible preventive action plans.« less

Dad's in the Garage: Santa Barbara Physicists in the Long 1970s

NASA Astrophysics Data System (ADS)

Mody, Cyrus

2013-03-01

American physicists faced many challenges in the 1970s: declining research budgets; public skepticism of scientific authority; declining student enrollments; and pressure to shift to topics such as biomedicine, environmental remediation, alternative energy, public housing and transport, and disability technologies. This paper examines the responses to these challenges of a small group of Santa Barbara physicists. While this group is not representative of the American physics profession, the success and failure of their responses to changed conditions tells us something about how American physicists got through the 1970s, and about the origins of some features of American physics today. The three physicists examined here are Philip Wyatt, David Phillips, and Virgil Elings. In the late `60s, Wyatt left a defense think tank to found an instrumentation firm. The Santa Barbara oil spill and other factors pushed that firm toward civilian markets in biomedicine and pollution measurement. Phillips joined Wyatt's firm from UCSB, while also founding his own company, largely to sell electronic devices for parapsychology. Phillips was also the junior partner in a master's of scientific instrumentation degree curriculum founded by Elings in order to save UCSB Physics' graduate program. Through the MSI program, Elings moved into biomedical research and became a serial entrepreneur. By the 1990s, Wyatt, Phillips, and Elings' turn toward academic entrepreneurship, dual military-civilian markets for physics start-ups, and interdisciplinary collaborations between physicists and life scientists were no longer unusual. Together, their journey through the `70s shows how varied the physics' profession's response to crisis was, and how much it pivoted on new interactions between university and industry.

New US philanthropy alliance picks physicist as boss

NASA Astrophysics Data System (ADS)

Kruesi, Liz

2015-04-01

Marc Kastner, a physicist at the Massachusetts Institute of Technology (MIT), has become the first president of the Science Philanthropy Alliance (SPA) - a new group of six organizations aiming to increase private funding for fundamental research in the US.

Pattern of perioperative cardiac arrests at University of Maiduguri Teaching Hospital.

PubMed

Kwari, Y D; Bello, M R; Eni, U E

2010-01-01

Perioperative cardiac arrests and death on the table represent the most serious complications of surgery and anaesthesia. This paper was designed to study their pattern, causes and outcomes following cardiopulmonary resuscitation (CPR) and intensive care unit (ICU) management in our institution. Three year retrospective review of perioperative cardiac arrests and death on operating table following surgical procedure under anaesthesia. For each cardiac arrest or death on the table the sequence of events leading to the arrest was evaluated using case notes, anaesthetic chart and ICU records. Study variables which include demographic data, ASA score, anaesthetic technique, causes and outcome were analysed and discussed. Fourteen perioperative cardiac arrests were encountered following 4051 anaesthetics administered over the three year study period. Twelve out of the fourteen cardiac arrests occurred following general anaesthesia, while the remaining two occurred following spinal anaesthesia. There was no cardiac arrest following local anaesthesia. Children suffered more cardiac arrest than adults. ASA class III and IV risk status suffered more arrests than ASA I and II. Hypoxia from airway problems was the commonest cause of cardiac arrest followed by septic shock. Monitoring with pulse oximeter was done in only 4 out of the 14 cardiac arrests. Only 2 (14%) out of 14 cardiac arrests recovered to home discharge, one of them with significant neurological deficit. Majority of arrests were due to hypoxia from airway problems that were not detected early There is need to improve on patient monitoring, knowledge of CPR and intensive care so as to improve the outcome of perioperative cardiac arrest.

On the Late Development and Possible Astronomical Origin of the Gyroscope

NASA Astrophysics Data System (ADS)

Brecher, Kenneth

2013-01-01

The invention of the gyroscope is usually attributed to the French physicist Jean-Bernard-Leon Foucault in the year 1852. He certainly created the word and also used his gyroscope to demonstrate the rotation of the Earth. However, the gyroscope was actually invented around 1812 by the German scientist Johann Bohnenberger who called his device simply the “machine”. Bohnenberger was a professor of astronomy and mathematics and published a book about astronomy in 1811. Several other scientists, including American physicist Walter R. Johnson (who called his apparatus the “rotascope”), independently invented the gyroscope. Each of these devices employed a central object (sphere or disc) that could spin on a shaft. This object was placed between three independent gimbals, two of which could move freely. Bohnenberger’s “machine” has much the same appearance as an armillary sphere. Those astronomical devices had been produced for at least the preceding three centuries and were widely dispersed and well known throughout Europe. They were used to display the apparent motion of celestial bodies. However, armillary spheres were used only as simulations of celestial appearances, not as actual demonstrations of physical phenomena. It is not known if the inertial properties of armillary spheres (and also of terrestrial and celestial globes) had been studied before about 1800. Nonetheless, as a matter of practice, gimbal systems similar to those found in gyroscopes were used on ships to level oil lamps at least as early as the sixteenth century AD. And the ideas behind armillary spheres date back at least a millennium before that. So why did the invention of the gyroscope in its modern form take such a long time when the individual underlying components had been around and utilized for some two millennia? Perhaps because the understanding of angular momentum, including its conservation, was not developed until the start of the 19th century and also because the technologies necessary to make practical gyroscopes were only developed later in the 19th century. This study was supported in part by NSF Grant # DUE-0715975 for Project LITE.

Physicist scorns syllabus that 'ill-equips' students

NASA Astrophysics Data System (ADS)

Randall, Ian

2017-03-01

Quantum physicist Michelle Simmons from the University of New South Wales has criticized the Australian school physics curriculum for reducing maths-based teaching and over-emphasizing essay-based questions - a move she says has left students “ill-equipped” on reaching university.

AFOMP Policy Statement No. 3: recommendations for the education and training of medical physicists in AFOMP countries.

PubMed

Round, W H; Ng, K H; Healy, B; Rodriguez, L; Thayalan, K; Tang, F; Fukuda, S; Srivastava, R; Krisanachinda, A; Shiau, A C; Deng, X; Han, Y

2011-09-01

AFOMP recognizes that clinical medical physicists should demonstrate that they are competent to practice their profession by obtaining appropriate education, training and supervised experience in the specialties of medical physics in which they practice, as well as having a basic knowledge of other specialties. To help its member countries to achieve this, AFOMP has developed this policy to provide guidance when developing medical physicist education and training programs. The policy is compatible with the standards being promoted by the International Organization for Medical Physics and the International Medical Physics Certification Board.

Professional development

NASA Astrophysics Data System (ADS)

Yoon, Jin Hee; Hartline, Beverly Karplus; Milner-Bolotin, Marina

2013-03-01

The three sessions of the professional development workshop series were each designed for a different audience. The purpose of the first session was to help mid-career physicists aspire for and achieve leadership roles. The second session brought together students, postdoctoral fellows, and early-career physicists to help them plan their career goals and navigate the steps important to launching a successful career. The final session sought to increase awareness of the results of physics education research, and how to use them to help students-especially women-learn physics better. The presentations and discussions were valuable for both female and male physicists.

The Role of Physicists in Policy Making

NASA Astrophysics Data System (ADS)

Handler, Thomas

2011-10-01

Since World War II, physicists have been involved in various aspects of national life. The roles played have included: 1) Pure or applied researcher, 2) Advisor to policy makers, and 3) Congressman. Today there are many challenges and questions that the United States faces and scientists, physicists included, are often asked on how these challenges should be addressed. In addressing these concerns what is the ``proper'' role that scientists should play? Do scientists even know what the possible roles are? This talk will briefly address the possible roles that scientists play and what other avenues of input go into the making of policy.

Physics and the car business

NASA Astrophysics Data System (ADS)

Compton, W. Dale; Reitz, John R.

1981-01-01

Physicists have made important contributions to many areas of Ford Motor Company activity, particularly in areas of basic and applied research and product development. A number have assumed positions with management responsibility. Many of the technical problems facing the automotive industry today require a fundamental understanding, and the ability of physicists to contribute to the solution of these problems is greater now than it has been in the past. The present paper discusses some of these problems, and also traces a few case histories of physicists at Ford Motor Company; these illustrate the wide diversity of career paths for persons entering industry with a physics background.

Physics Climate as Experienced by LGBT+ Physicists

NASA Astrophysics Data System (ADS)

Long, Elena

2012-02-01

In 2009, Elena Long created the LGBT+ Physicists website (http://lgbtphysicists.x10hosting.com) as a warehouse for resources useful for sexual and gender minorities working in physics. This resource has grown to include networking resources, lists of LGBT-friendly universities and localities, recommendations for enacting positive change in physics communities, and out-reach to other STEM-oriented LGBT organizations. This has been possible in large part by the dynamic community of LGBT+ physicists and allies looking to make physics more welcoming towards our community. In 2011, Elena used hir position as Member at Large on the executive committee of the Forum of Graduate Student Affairs (FGSA) to conduct a climate survey that included, among other things, the first serious look at LGBT+ demographics in physics. The survey focused particularly on issues of language heard and harassment experienced by physicists and was broken down into categories based on race, physical and mental ability, gender, and sexuality. Furthermore, it examined the outcomes of experienced harassment and the reasons for when harassment was not reported. Due to the nature of the study, overlapping demographics, especially ``multiple minorities,'' were also explored. This talk will give a brief history of the LGBT+ Physicists resource as well as an overview of the FGSA study.

SU-B-213-00: Education Council Symposium: Accreditation and Certification: Establishing Educational Standards and Evaluating Candidates Based on these Standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization.more » In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.« less

Importance of the first link: description and recognition of an out-of-hospital cardiac arrest in an emergency call.

PubMed

Berdowski, Jocelyn; Beekhuis, Freerk; Zwinderman, Aeilko H; Tijssen, Jan G P; Koster, Rudolph W

2009-04-21

The content of emergency calls for suspected cardiac arrest is rarely analyzed. This study investigated the recognition of a cardiac arrest by dispatchers and its influence on survival rates. During 8 months, voice recordings of 14,800 consecutive emergency calls were collected to audit content and cardiac arrest recognition. The presence of cardiac arrest during the call was assessed from the ambulance crew report. Included calls were placed by laypersons on site and did not involve trauma. Prevalence of cardiac arrest was 3.0%. Of the 285 cardiac arrests, 82 (29%) were not recognized during the call, and 64 of 267 suspected calls (24%) were not cardiac arrest. We analyzed a random sample (n=506) of 9230 control calls. Three-month survival was 5% when a cardiac arrest was not recognized versus 14% when it was recognized (P=0.04). If the dispatcher did not recognize the cardiac arrest, the ambulance was dispatched a mean of 0.94 minute later (P<0.001) and arrived 1.40 minutes later on scene (P=0.01) compared with recognized calls. The main reason for not recognizing the cardiac arrest was not asking if the patient was breathing (42 of 82) and not asking to describe the type of breathing (16 of 82). Normal breathing was never mentioned in true cardiac arrest calls. A logistic regression model identified spontaneous trigger words like facial color that could contribute to cardiac arrest recognition (odds ratio, 7.8 to 9.7). Not recognizing a cardiac arrest during emergency calls decreases survival. Spontaneous words that the caller uses to describe the patient may aid in faster and better recognition of a cardiac arrest.

Statistical correlations of crime with arrests

NASA Astrophysics Data System (ADS)

Kuelling, Albert C.

1997-01-01

Regression analysis shows that the overall crime rate correlates with the overall arrest rate. Violent crime only weakly correlates with the violent arrest rate, but strongly correlates with the property arrest rate. Contrary to common impressions, increasing arrest rates do not significantly increase loading on incarceration facilities.

Ya.B. Zel''dovich (1914-1987). Chemist, Nuclear Physicist, Cosmologist

NASA Astrophysics Data System (ADS)

Sahni, Varun

2011-06-01

A scientific biography of the outstanding Soviet Chemist, Physicist and Cosmologist Yakov Borisovich Zeldovich (1914-1987) has been given by one of his pupils. A special concern has been given to cosmological works by Zel'dovich. Figures 4,Bibliography: 9.

The Vector Calculus Gap: Mathematics (Does Not Equal) Physics.

ERIC Educational Resources Information Center

Dray, Tevian; Manogue, Corinne A.

1999-01-01

Discusses some of the differences between the ways mathematicians and physicists view vector calculus and the gap between the way this material is traditionally taught by mathematicians and the way physicists use it. Suggests some ways to narrow the gap. (Author/ASK)

Site-specific thromboembolism: a novel animal model for stroke.

PubMed

Ringer, Andrew J; Guterman, Lee R; Hopkins, L Nelson

2004-02-01

To develop a technique for site-specific placement of a thrombus of predetermined volume in an animal model for the purpose of evaluating methods of intravascular thrombolysis and clot retrieval. Six swine were subjected to thrombus injection bilaterally in the ascending pharyngeal artery (APA). Each animal underwent transfemoral angiography while under general anesthesia. A nondetachable balloon catheter and a 3-French microcatheter were then advanced into the common carotid artery through a 7-French guide catheter. With the microcatheter in the proximal APA and the balloon inflated proximally, a bolus of preformed thrombus composed of 0.9 mL of autologous blood and 0.1 mL of bovine thrombin (200 IU/mL) was injected through the microcatheter while local flow arrest was maintained for 15 min. The balloon was deflated and removed. The occluded arteries were observed by serial angiography for 3 hr and then resected for gross examination and hematoxylin and eosin staining. Each APA was occluded angiographically and did not recanalize during the 3-hr observation period. Persistent, proximal progression of thrombus to the superior thyroid artery origin occurred in three animals. Gross inspection revealed that the resected arteries contained thrombus in the proximal APA but not in the common carotid artery. Histologic examination revealed organized thrombus, without evidence of intimal injury. Our model provides a simple, reliable method for site-specific injection of a thrombus of predetermined volume. Site-specific placement is important for evaluation of the efficacy of thrombolytic agents and techniques. Angiographic evidence of brain revascularization can be used to grade revascularization and clot volume. The ability to specifically localize and estimate clot volume makes our model well suited for the evaluation and comparison of thrombolytic agents and endovascular techniques.

MO-DE-304-02: Diagnostic Workforce Subcommittee Status and Direction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gress, D.

2015-06-15

The Abt study of medical physicist work values for radiation oncology physics services, Round IV is completed. It supersedes the Abt III study of 2008. The 2015 Abt study measured qualified medical physicist (QMP) work associated with routine radiation oncology procedures as well as some special procedures. As before, a work model was created to allow the medical physicist to defend QMP work based on both routine and special procedures service mix. The work model can be used to develop a cost justification report for setting charges for radiation oncology physics services. The Abt study Round IV was designed tomore » empower the medical physicist to negotiate a service or employment contract with providers based on measured national QMP workforce and staffing data. For a variety of reasons, the diagnostic imaging contingent of AAPM has had a more difficult time trying estimate workforce requirements than their therapy counterparts. Over the past several years, the Diagnostic Work and Workforce Study Subcommittee (DWWSS) has collected survey data from AAPM members, but the data have been very difficult to interpret. The DWWSS has reached out to include more AAPM volunteers to create a more full and accurate representation of actual clinical practice models on the subcommittee. Though much work remains, through hours of discussion and brainstorming, the DWWSS has somewhat of a clear path forward. This talk will provide attendees with an update on the efforts of the subcommittee. Learning Objectives: Understand the new information documented in the Abt studies. Understand how to use the Abt studies to justify medical physicist staffing. Learn relevant historical information on imaging physicist workforce. Understand the process of the DWWSS in 2014. Understand the intended path forward for the DWWSS.« less

MO-DE-304-00: Workforce Assessment Committee Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2015-06-15

The Abt study of medical physicist work values for radiation oncology physics services, Round IV is completed. It supersedes the Abt III study of 2008. The 2015 Abt study measured qualified medical physicist (QMP) work associated with routine radiation oncology procedures as well as some special procedures. As before, a work model was created to allow the medical physicist to defend QMP work based on both routine and special procedures service mix. The work model can be used to develop a cost justification report for setting charges for radiation oncology physics services. The Abt study Round IV was designed tomore » empower the medical physicist to negotiate a service or employment contract with providers based on measured national QMP workforce and staffing data. For a variety of reasons, the diagnostic imaging contingent of AAPM has had a more difficult time trying estimate workforce requirements than their therapy counterparts. Over the past several years, the Diagnostic Work and Workforce Study Subcommittee (DWWSS) has collected survey data from AAPM members, but the data have been very difficult to interpret. The DWWSS has reached out to include more AAPM volunteers to create a more full and accurate representation of actual clinical practice models on the subcommittee. Though much work remains, through hours of discussion and brainstorming, the DWWSS has somewhat of a clear path forward. This talk will provide attendees with an update on the efforts of the subcommittee. Learning Objectives: Understand the new information documented in the Abt studies. Understand how to use the Abt studies to justify medical physicist staffing. Learn relevant historical information on imaging physicist workforce. Understand the process of the DWWSS in 2014. Understand the intended path forward for the DWWSS.« less

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.

PubMed

Blagosklonny, Mikhail V

2012-03-01

Cell cycle arrest is not yet senescence. When the cell cycle is arrested, an inappropriate growth-promotion converts an arrest into senescence (geroconversion). By inhibiting the growth-promoting mTOR pathway, rapamycin decelerates geroconversion of the arrested cells. And as a striking example, while causing arrest, p53 may decelerate or suppress geroconversion (in some conditions). Here I discuss the meaning of geroconversion and also the terms gerogenes, gerossuppressors, gerosuppressants, gerogenic pathways, gero-promoters, hyperfunction and feedback resistance, regenerative potential, hypertrophy and secondary atrophy, pro-gerogenic and gerogenic cells.

Explaining Discrepancies in Arrest Rates Between Black and White Male Juveniles

PubMed Central

Fite, Paula J.; Wynn, Porche’; Pardini, Dustin A.

2010-01-01

The authors investigated discrepancies in arrest rates between Black and White male juveniles by examining the role of early risk factors for arrest. Two hypotheses were evaluated: (a) Disproportionate minority arrest is due to increased exposure to early risk factors, and (b) a differential sensitivity to early risk factors contributes to disproportionate minority arrest. The study included 481 Black and White boys who were followed from childhood to early adulthood. A higher incidence of early risk factors accounted for racial differences related to any juvenile arrest, as well as differences in violence- and theft-related arrests. However, increased exposure to early risk factors did not explain race differences in drug-related arrests. Minimal support was found for the hypothesis that a differential sensitivity to risk factors accounts for disproportionate rate of minority male arrests. In sum, most racial discrepancies in juvenile male arrests were accounted for by an increased exposure to childhood risk factors. Specifically, Black boys were more likely to display early conduct problems and low academic achievement and experience poor parent–child communication, peer delinquency, and neighborhood problems, which increased their risk for juvenile arrest. PMID:19803571

A Primer for Education/Outreach to the Classroom and Community

NASA Astrophysics Data System (ADS)

Zaleskiewicz, Ted

2002-11-01

As one example of successful cooperation among major plasma/fusion research laboratories in the United States and Europe, we discuss the development of the well-known classroom teaching chart, "Fusion - Physics of a Fundamental Energy Source", and associated materials produced by the Contemporary Physics Education Project(CPEP). CPEP is a not-for-profit organization of physicists and teachers incorporated to develop teaching materials on contemporary physics topics suitable for use in the introductory (high school and college) classroom. The Fusion Chart is currently available in 7 languages: English, Flemish, French, German, Italian, Portuguese, and Spanish. The series of supporting materials include a Teacher's Guide, 7 hands-on classroom activities, and a Web supplement at http://FusEdWeb.pppl.gov/CPEP/chart.html. All materials are being used successfully in high school teacher training workshops across North America under the auspices of APS/DPP, AAPT, and PTRA (Physics Teaching Resource Agents) programs. Though the materials were developed primarily for use by classroom teachers, they are also valuable resources for individual experts who have the opportunity to make presentations to educational or civic groups. This talk will illustrate various teaching strategies which increase the effectiveness of the materials, including demonstrations of two of the classroom activities, with audience participation invited.

AAPM Task Group 103 report on peer review in clinical radiation oncology physics

PubMed Central

Halvorsen, Per H.; Das, Indra J.; Fraser, Martin; Freedman, D. Jay; Rice, Robert E.; Ibbott, Geoffrey S.; Parsai, E. Ishmael; Robin, T. Tydings; Thomadsen, Bruce R.

2005-01-01

This report provides guidelines for a peer review process between two clinical radiation oncology physicists. While the Task Group's work was primarily focused on ensuring timely and productive independent reviews for physicists in solo practice, these guidelines may also be appropriate for physicists in a group setting, particularly when dispersed over multiple separate clinic locations. To ensure that such reviews enable a collegial exchange of professional ideas and productive critique of the entire clinical physics program, the reviews should not be used as an employee evaluation instrument by the employer. Such use is neither intended nor supported by this Task Group. Detailed guidelines are presented on the minimum content of such reviews, as well as a recommended format for reporting the findings of a review. In consideration of the full schedules faced by most clinical physicists, the process outlined herein was designed to be completed in one working day. PACS numbers: 87.53.Xd, 87.90.+y PMID:16421500

Future forum, Hobart, October 29, 2017: examining the role of medical physics in cancer research.

PubMed

Ebert, Martin A; Hardcastle, Nicholas; Kron, Tomas

2018-06-25

This commentary reports on a forum held in October 2017 in Hobart, Tasmania, attended by 20 Australasian medical physicists, to consider the future role of medical physics, as well as non-medical physics and allied disciplines, in oncology research. Attendees identified important areas of oncology research which physicists can be contributing to, with these evaluated in the context of a set of "Provocative Questions" recently generated by the American Association of Physicists in Medicine. Primary perceived barriers to participation in research were identified, including a "lack of knowledge of cancer science", together with potential solutions. Mechanisms were considered for engagement with the broader scientific community, consumers, advocates and policy makers. In considering future opportunities in oncology research for medical physicists, it was noted that a professional need to focus on the safety and accuracy of current treatments applied to patients, encouraging risk-aversion, is somewhat in competition with the role of physical scientists in the exploration and discovery of new concepts and understandings.

Radiation Oncology Physics and Medical Physics Education

NASA Astrophysics Data System (ADS)

Bourland, Dan

2011-10-01

Medical physics, an applied field of physics, is the applications of physics in medicine. Medical physicists are essential professionals in contemporary healthcare, contributing primarily to the diagnosis and treatment of diseases through numerous inventions, advances, and improvements in medical imaging and cancer treatment. Clinical service, research, and teaching by medical physicists benefits thousands of patients and other individuals every day. This talk will cover three main topics. First, exciting current research and development areas in the medical physics sub-specialty of radiation oncology physics will be described, including advanced oncology imaging for treatment simulation, image-guided radiation therapy, and biologically-optimized radiation treatment. Challenges in patient safety in high-technology radiation treatments will be briefly reviewed. Second, the educational path to becoming a medical physicist will be reviewed, including undergraduate foundations, graduate training, residency, board certification, and career opportunities. Third, I will introduce the American Association of Physicists in Medicine (AAPM), which is the professional society that represents, advocates, and advances the field of medical physics (www.aapm.org).

Women in physics in Bangladesh

NASA Astrophysics Data System (ADS)

Choudhury, Shamima K.

2013-03-01

Bangladesh has had a glorious physics tradition since the beginning of the last century, when the physicist S.N. Bose published a groundbreaking paper with Albert Einstein on Bose-Einstein statistics. However, women in Bangladesh traditionally have not been able to make their way in the realm of science in general and physics in particular. Since Bangladesh achieved independence in 1971, the situation has gradually changed and more and more women choose physics as an academic discipline. The percentage of women students in physics rose from 10% in 1970 to almost 30% in 2010. In recent years, women physicists have actively participated in many activities promoting science and technology, creating awareness among the public about the importance of physics education. The present status of women physicists in academic, research, and administrative programs in the government and private sectors in Bangladesh is reported. The greater inclusion of women scientists, particularly physicists, in policy-making roles on important issues of global and national interest is suggested.

SU-B-BRA-00: The Medical Physicist Value Proposition for Tomorrow and Today

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherouse, G.

In the current rapidly changing Healthcare environment, many groups are competing for limited resources. How can medical physicists position themselves to be a relevant stakeholder in the discussion of how those resources are allocated Our value goes beyond what can be shown in a business plan and is heavily involved with safety and quality. Three areas will be explored: What is our value? Who needs to receive that message? How do we communicate that message? To help frame the discussion in terms of how other stakeholders may view the value of medical physicists, a physician and an administrator will presentmore » their perspective. Lastly, a multidisciplinary panel will present real life examples of strategies that can be utilized today to establish the value of medical physicists. The presentation of these examples will lead into an interactive question and answer time. V. Willcut, I work for Elekta. There was no research associated with this talk.« less

Physicists in Primary Schools (PIPS) Project: Fun Presentations for Physicists to Take into Schools Worldwide (abstract)

NASA Astrophysics Data System (ADS)

Marks, Ann

2009-04-01

The Physicists in Primary Schools (PIPS) project is a joint venture initiated by the UK Women in Physics Group. A team from the University of Sheffield, with Engineering and Physical Sciences Research Council funding, has developed fun presentations and novel class activities using everyday articles for physicists to take into primary schools. The objectives are to instill enthusiasm in young children-including girls-through the enjoyment and excitement of physics, and support primary school teachers with a curriculum which includes many abstract concepts. All PIPS material is free to download from the Institute of Physics website (www.iop.org/pips), providing PowerPoint presentations and detailed explanations, as well as videos of the activities in classrooms. The topics are suitable for children age 4 to 11 years. There is interest in translating the presentations into other languages as there are few words on the slides and the material is likely valuable for older age groups. The presentations therefore have the potential to be useful worldwide.

Germany-US Nuclear Theory Exchange Program for QCD Studies of Hadrons & Nuclei 'GAUSTEQ'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dudek, Jozef; Melnitchouk, Wally

GAUSTEQ was a Germany-U.S. exchange program in nuclear theory whose purpose was to focus research efforts on QCD studies of hadrons and nuclei, centered around the current and future research programs of Jefferson Lab and the Gesellschaft fur Schwerionenforschung (GSI) in Germany. GAUSTEQ provided travel support for theoretical physicists at US institutions conducting collaborative research with physicists in Germany. GSI (with its Darmstadt and Helmholtz Institute Mainz braches) served as the German “hub” for visits of U.S. physicists, while Jefferson Lab served as the corresponding “hub” for visits of German physicists visiting U.S. institutions through the reciprocal GUSTEHP (German-US Theorymore » Exchange in Hadron Physics) program. GAUSTEQ was funded by the Office of Nuclear Physics of the U.S. Department of Energy, under Contract No.DE-SC0006758 and officially managed through Old Dominion University in Norfolk, Virginia. The program ran between 2011 and 2015.« less

Nuclear and radiological emergencies: Building capacity in medical physics to support response.

PubMed

Berris, Theocharis; Nüsslin, Fridtjof; Meghzifene, Ahmed; Ansari, Armin; Herrera-Reyes, Eduardo; Dainiak, Nicholas; Akashi, Makoto; Gilley, Debbie; Ohtsuru, Akira

2017-10-01

Medical physicists represent a valuable asset at the disposal of a structured and planned response to nuclear or radiological emergencies (NREs), especially in the hospital environment. The recognition of this fact led the International Atomic Energy Agency (IAEA) and the International Organization for Medical Physics (IOMP) to start a fruitful collaboration aiming to improve education and training of medical physicists so that they may support response efforts in case of NREs. Existing shortcomings in specific technical areas were identified through international consultations supported by the IAEA and led to the development of a project aiming at preparing a specific and standardized training package for medical physicists in support to NREs. The Project was funded through extra-budgetary contribution from Japan within the IAEA Nuclear Safety Action Plan. This paper presents the work accomplished through that project and describes the current steps and future direction for enabling medical physicists to better support response to NREs. Copyright © 2017 Associazione Italiana di Fisica Medica. All rights reserved.

After the War: Women in Physics in the United States

NASA Astrophysics Data System (ADS)

Howes, Ruth H.; Herzenberg, Caroline L.

2015-12-01

This book examines the lives and contributions of American women physicists who were active in the years following World War II, during the middle decades of the 20th century. It covers the strategies they used to survive and thrive in a time where their gender was against them. The percentage of woman taking PhDs in physics has risen from 6% in 1983 to 20% in 2012 (an all-time high for women). By understanding the history of women in physics, these gains can continue. It discusses two major classes of women physicists; those who worked on military projects, and those who worked in industrial laboratories and at universities largely in the late 1940s and 1950s. While it includes minimal discussion of physics and physicists in the 1960s and later, this book focuses on the challenges and successes of women physicists in the years immediately following World War II and before the eras of affirmative actions and the use of the personal computer.

An observational study describing the geographic-time distribution of cardiac arrests in Singapore: what is the utility of geographic information systems for planning public access defibrillation? (PADS Phase I).

PubMed

Ong, Marcus Eng Hock; Tan, Eng Hoe; Yan, Xiuyuan; Anushia, P; Lim, Swee Han; Leong, Benjamin Sieu-Hon; Ong, Victor Yeok Kein; Tiah, Ling; Yap, Susan; Overton, Jerry; Anantharaman, V

2008-03-01

Public access defibrillation (PAD) has shown potential to increase cardiac arrest survival rates. To describe the geographic epidemiology of prehospital cardiac arrest in Singapore using geographic information systems (GIS) technology and assess the potential for deployment of a PAD program. We conducted an observational prospective study looking at the geographic location of pre-hospital cardiac arrests in Singapore. Included were all patients with out-of-hospital cardiac arrest (OHCA) presented to emergency departments. Patient characteristics, cardiac arrest circumstances, emergency medical service (EMS) response and outcomes were recorded according to the Utstein style. Location of cardiac arrests was spot-mapped using GIS. From 1 October 2001 to 14 October 2004, 2428 patients were enrolled into the study. Mean age for arrests was 60.6 years with 68.0% male. 67.8% of arrests occurred in residences, with 54.5% bystander witnessed and another 10.5% EMS witnessed. Mean EMS response time was 9.6 min with 21.7% receiving prehospital defibrillation. Cardiac arrest occurrence was highest in the suburban town centers in the Eastern and Southern part of the country. We also identified communities with the highest arrest rates. About twice as many arrests occurred during the day (07:00-18:59 h) compared to night (19:00-06:59 h). The categories with the highest frequencies of occurrence included residential areas, in vehicles, healthcare facilities, along roads, shopping areas and offices/industrial areas. We found a definite geographical distribution pattern of cardiac arrest. This study demonstrates the utility of GIS with a national cardiac arrest database and has implications for implementing a PAD program, targeted CPR training, AED placement and ambulance deployment.

Sex Disparities in Arrest Outcomes for Domestic Violence

ERIC Educational Resources Information Center

Hamilton, Melissa; Worthen, Meredith G. F.

2011-01-01

Domestic violence arrests have been historically focused on protecting women and children from abusive men. Arrest patterns continue to reflect this bias with more men arrested for domestic violence compared to women. Such potential gender variations in arrest patterns pave the way to the investigation of disparities by sex of the offender in…

"House Arrest" or "Developmental Arrest"? A Study of Youth Under House Arrest.

PubMed

Chamiel, Elad; Walsh, Sophie D

2018-06-01

Studies have examined the potential benefits and risks of alternative forms of detention, such as house arrest, for adults but, despite its growing use, little research has examined the implications of house arrest for juveniles. The current research examined the experience of 14 adolescents under house arrest. Six main themes were identified in the narratives of the participants: the experience of detention, daily schedule and utilization of time, emotions and self-reflection, relationships with peers, relation to parents and supervisor(s), and contact with professionals. Findings emphasized the potential developmental dangers of house arrest at the critical stage of adolescence. Yet, analysis also showed that the period of house arrest has the potential to be a period of positive changes, and can be used for successful rehabilitation.

A Different Laboratory Tale: Fifty Years of Mössbauer Spectroscopy

NASA Astrophysics Data System (ADS)

Westfall, Catherine

2006-05-01

I explore the fifty-year development of Mössbauer spectroscopy by focusing on three episodes in its development at Argonne National Laboratory: work by nuclear physicists using radioactive sources in the early 1960s, work by solid-state physicists using radioactive resources from the mid- 1960s through the 1970s,and work by solid-state physicists using the Advanced Photon Source from the 1980s to 2005. These episodes show how knowledge about the properties of matter was produced in a national-laboratory context and highlights the web of connections that allow nationallaboratory scientists working at a variety of scales to produce both technological and scientific innovations.

Herbert Fröhlich: A Physicist Ahead of His Time, by G.J. Hyland [Book Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devanathan, Ram

This authoritative biography of Herbert Fröhlich (1905-1991), a well-known theoretical physicist, paints an intimate portrait of a pioneering scientist who made seminal contributions to condensed matter physics and left his mark on other domains such as biology over a 60-year career. From his vantage point as the last graduate student of this eminent physicist, Gerard Hyland has produced an account that weaves the personal experiences and travails of Fröhlich with detailed discussion of the theory of dielectrics. The political upheavals in Europe during the 20th century provide a dramatic backdrop for the narrative.

Wars of the holographic world

NASA Astrophysics Data System (ADS)

Preskill, John

2008-12-01

In the popular imagination, the iconic American theoretical physicist is Richard Feynman, in all his safe-cracking, bongo-thumping, woman-chasing glory. I suspect that many physicists, if asked to name a living colleague who best captures the spirit of Feynman, would give the same answer as me: Leonard Susskind. As far as I know, Susskind does not crack safes, thump bongos, or chase women, yet he shares Feynman's brash cockiness (which in Susskind's case is leavened by occasional redeeming flashes of self-deprecation) and Feynman's gift for spinning fascinating anecdotes. If you are having a group of physicists over for dinner and want to be sure to have a good time, invite Susskind.

From Newton to Einstein; Ask the physicist about mechanics and relativity

NASA Astrophysics Data System (ADS)

Baker, F. Todd

2014-12-01

Since 2006 the author has run a web site, WWW.AskThePhysicist.com, where he answers questions about physics. The site is not intended for answering highly technical questions; rather the purpose is to answer, with as little mathematics and formalism as possible, questions from intelligent and curious laypersons. This book is about classical mechanics. Usually `classical' calls to mind Newtonian mechanics and that is indeed where modern physics started. The bulk of the book is devoted to sections which will contain mainly categorized groups of Q&As from the web site, sort of a Best of Ask the Physicist.

Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion

PubMed Central

Rolland, Stéphane G.; Motori, Elisa; Memar, Nadin; Hench, Jürgen; Frank, Stephan; Winklhofer, Konstanze F.; Conradt, Barbara

2013-01-01

Mitochondrial morphology changes in response to various stimuli but the significance of this is unclear. In a screen for mutants with abnormal mitochondrial morphology, we identified MMA-1, the Caenorhabditis elegans homolog of the French Canadian Leigh Syndrome protein LRPPRC (leucine-rich pentatricopeptide repeat containing). We demonstrate that reducing mma-1 or LRPPRC function causes mitochondrial hyperfusion. Reducing mma-1/LRPPRC function also decreases the activity of complex IV of the electron transport chain, however without affecting cellular ATP levels. Preventing mitochondrial hyperfusion in mma-1 animals causes larval arrest and embryonic lethality. Furthermore, prolonged LRPPRC knock-down in mammalian cells leads to mitochondrial fragmentation and decreased levels of ATP. These findings indicate that in a mma-1/LRPPRC–deficient background, hyperfusion allows mitochondria to maintain their functions despite a reduction in complex IV activity. Our data reveal an evolutionary conserved mechanism that is triggered by reduced complex IV function and that induces mitochondrial hyperfusion to transiently compensate for a drop in the activity of the electron transport chain. PMID:23878239

77 FR 62538 - Advisory Committee on the Medical Uses of Isotopes: Call for Nominations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

...) nuclear medicine physicist; (d) therapy medical physicist; (e) radiation safety officer; (f) nuclear... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Call for Nominations AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Call for nominations. SUMMARY: The U.S...

ORNL Physicist Aims for the Stars with JENSA System

ScienceCinema

Chipps, Kelly

2018-01-16

Physicists studying stellar explosions, the origin of life and just about everything in between could gain light years in precision because of a system inspired by a team led by Kelly Chipps of the Department of Energy’s Oak Ridge National Laboratory.

Good scientists and honest people

NASA Astrophysics Data System (ADS)

Robinson, Andrew

2014-06-01

In early 1948, less than three years after the end of the Second World War in Europe, Werner Heisenberg - the Nobel laureate and physicist leader of the failed German atomic bomb project - was invited to the UK as part of an attempt to repair relations between British and German physicists.

"Shut up and calculate": the available discursive positions in quantum physics courses

NASA Astrophysics Data System (ADS)

Johansson, Anders; Andersson, Staffan; Salminen-Karlsson, Minna; Elmgren, Maja

2018-03-01

Educating new generations of physicists is often seen as a matter of attracting good students, teaching them physics and making sure that they stay at the university. Sometimes, questions are also raised about what could be done to increase diversity in recruitment. Using a discursive perspective, in this study of three introductory quantum physics courses at two Swedish universities, we instead ask what it means to become a physicist, and whether certain ways of becoming a physicist and doing physics is privileged in this process. Asking the question of what discursive positions are made accessible to students, we use observations of lectures and problem solving sessions together with interviews with students to characterize the discourse in the courses. Many students seem to have high expectations for the quantum physics course and generally express that they appreciate the course more than other courses. Nevertheless, our analysis shows that the ways of being a "good quantum physics student" are limited by the dominating focus on calculating quantum physics in the courses. We argue that this could have negative consequences both for the education of future physicists and the discipline of physics itself, in that it may reproduce an instrumental "shut up and calculate"-culture of physics, as well as an elitist physics education. Additionally, many students who take the courses are not future physicists, and the limitation of discursive positions may also affect these students significantly.

TH-B-12A-01: TG124 “A Guide for Establishing a Credentialing and Privileging Program for Users of Fluoroscopic Equipment in Healthcare Organizations”

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, M

Fluoroscopy credentialing and privileging programs are being instituted because of recorded patient injuries and the widespread growth in fluoroscopy use by operators whose medical education did not include formal fluoroscopy training. This lack of training is recognized as a patient safety deficiency, and medical physicists and health physicists are finding themselves responsible for helping to establish fluoroscopy credentialing programs. While physicians are very knowledgeable about clinical credentials review and the privileging process, medical physicists and health physicists are not as familiar with the process and associated requirements. To assist the qualified medical physicist (QMP) and the radiation safety officer (RSO)more » with these new responsibilities, TG 124 provides an overview of the credentialing process, guidance for policy development and incorporating trained fluoroscopy users into a facility's established process, as well as recommendations for developing and maintaining a risk-based fluoroscopy safety training program. This lecture will review the major topics addressed in TG124 and relate them to practical situations. Learning Objectives: Understand the difference between credentialing and privileging. Understand the responsibilities, interaction and coordination among key individuals and committees. Understand options for integrating the QMP and/or RSO and Radiation Safety Committee into the credentialing and privileging process. Understand issues related to implementing the fluoroscopy safety training recommendations and with verifying and documenting successful completion.« less

Where no guideline has gone before: retrospective analysis of resuscitation in the 24th century.

PubMed

Hörburger, David; Haslinger, Julia; Bickel, Hubert; Graf, Nikolaus; Schober, Andreas; Testori, Christoph; Weiser, Christoph; Sterz, Fritz; Haugk, Moritz

2014-12-01

Evaluation of the treatment, epidemiology and outcome of cardiac arrest in the television franchise Star Trek. Retrospective cohort study of prospective events. Screening of all episodes of Star Trek: The Next Generation, Star Trek: Deep Space Nine and Star Trek: Voyager for cardiac arrest events. Documentation was performed according to the Utstein guidelines for cardiac arrest documentation. All adult, single person cardiac arrests were included. Patients were excluded if cardiac arrest occurred during mass casualties, if the victims were annihilated by energy weapons or were murdered and nobody besides the assassin could provide first aid. Epidemiological data, treatment and outcome of cardiac arrest victims in the 24th century were studied. Ninety-six cardiac arrests were included. Twenty-three individuals were female (24%). Cardiac arrest was witnessed in 91 cases (95%), trauma was the leading cause (n = 38; 40%). Resuscitation was initiated in 17 cases (18%) and 12 patients (13%) had return of spontaneous circulation. Favorable neurological outcome and long-term survival was documented in nine patients (9%). Technically diagnosed cardiac arrest was associated with higher rates of favorable neurological outcome and long-term survival. Neurological outcome and survival did not depend on cardiac arrest location. Cardiac arrest remains a critical event in the 24th century. We observed a change of etiology from cardiac toward traumatic origin. Quick access to medical help and new prognostic tools were established to treat cardiac arrest.

Fermilab Education: Physicists

Science.gov Websites

Search Education and Outreach: Resources and Opportunties for Fermilab employees and Users A variety of resources and opportunities are available for physicists interested in education and outreach (For general Data (6–12) Physical Science/Physics Instructional Resources (K–12) US Particle Physics Education and

Matter and Interactions: A Particle Physics Perspective

ERIC Educational Resources Information Center

Organtini, Giovanni

2011-01-01

In classical mechanics, matter and fields are completely separated; matter interacts with fields. For particle physicists this is not the case; both matter and fields are represented by particles. Fundamental interactions are mediated by particles exchanged between matter particles. In this article we explain why particle physicists believe in…

Gendered Hegemony and Its Contradictions among Finnish University Physicists

ERIC Educational Resources Information Center

Sannino, Annalisa; Vainio, Jenny

2015-01-01

This article addresses the issue of gender imbalance in Finnish universities in the domain of physics as a historical and dialectical phenomenon. Drawing from the Gramscian notion of hegemony and the activity-theoretical notion of contradiction, this paper analyses gendered hegemonic and contradictory forces steering physicists' careers. This…

History of Physicists in Industry. Final Report

ERIC Educational Resources Information Center

Anderson, R. Joseph; Butler, Orville R.

2008-01-01

This project is the first systematic study of the organizational structure, communications patterns, and archival records of industrial physicists in the U.S., and it provides general guidelines for understanding and documenting their work. The study confirms that the organization and management of industrial R&D is volatile, changing in response…

Complementary Colours for a Physicist

ERIC Educational Resources Information Center

Babic, Vitomir; Cepic, Mojca

2009-01-01

This paper reports on a simple experiment which enables splitting incident light into two different modes, each having a colour exactly complementary to the other. A brief historical development of colour theories and differences in a physicist's point of view with respect to an artist's one is discussed. An experimental system for producing…

Christmas in Physics Land

NASA Astrophysics Data System (ADS)

1999-01-01

A short story of everyday folk for the Yuletide season It was a beautiful scene. Children were sledging, or at least adults were sledging whilst the children waited for a go. Snow flakes were falling gently to the ground. The physicist was extremely content. All the snow flakes had a perfectly symmetric hexagonal crystal structure; the sledges were all reaching the bottom of the slope at just the correct velocity, neglecting heat loss due to friction. A skater went past. The physicist smiled. The change in melting point under the blades was just as it should have been, and angular momentum was completely conserved in the pirouette. A snowball hit the physicist squarely in the face, probably thrown by a geographer. But even this made the physicist laugh, as the trajectory was perfect, as long as you accounted for the changing mass. How different to last year when the physicist had spent Christmas in the real world. How glad he was that he had come to Physics Land for the festive season where everything was just as it ought to be. Someone in the crowd barged into him, but it didn't matter, he was a boson, so they just ignored each other. How horrid it had been last Christmas.... As a young man carrying a light ladder went past, whistling merrily and enjoying the experience of the Doppler effect, the physicist leant back against the perfectly smooth wall, revelling in the joy of resolving his forces on the rough ground... and began to think dark thoughts about the previous year. You see the problem with the real world was that it didn't understand physicists at all. Probably the worst place of all for a physicist was at a party. So often things would go wrong and he would leave early in disgrace. How well he remembered the evening when he had been curious whether it was a pnp or npn type semiconductor controlling the disco lights. It had taken barely three hours to reassemble the lights, and indeed improve on the flashing sequence by altering the reverse bias voltage, but no-one thanked him. Oh no, they were all just annoyed that he had dismantled the lights at all. That was the real world for you. Conversation had been difficult. People kept asking questions, but then didn't appear to be interested in the answer. One host had commented on the weather and then very rudely drifted off to another guest just as the physicist was making a clear distinction between rotating and inertial reference frames as the fundamental cause of the geostrophic wind. Another guest had made an equally bad impression by being clearly uninterested in a small digression on energy balance which seemed the obvious response to his comment about how warm the room had become as people began to dance. The physicist came out of his day dream. An old man was walking a dog on the end of a light inextensible string. A young girl on a swing was executing simple harmonic motion using a small-angle approximation in the park. Two older boys were investigating moments on a see-saw. A boisterous teenager was having a great time with the centripetal force on a roundabout. Yes, this was the life. In Physics Land, it would be a very merry Christmas. Philip Britton

Alcohol-related legal infractions and student retention.

PubMed

Thompson, Kevin M

2007-09-01

The present study employed municipal alcohol-related arrest reports to determine if being arrested/cited reduced the probability of academic retention. Alcohol-related legal infraction data implicating 1,310 college students was gathered during a 4-year period. First- through third-year students were identified in the database by cross-checking names in the campus directory. A random sample of nonarrested students functioned as the comparison group (n = 856). Students not appearing in the directory the following year were defined as nonretained students. Retention was not affected by the experience of one alcohol-related legal infraction. Retention odds were 31% lower for students experiencing multiple arrests, however, than for nonarrested or single-arrested students. Gender moderated the association between arrest and retention, with women who had been arrested more likely to return to school than those who had not been arrested. Retention odds were higher for arrested/cited students if they were in their second or third year of college, a fraternity/sorority member, or charged with an offense other than driving under the influence. Multi-arrested college students are at risk for attrition. Immersion in college life may reduce the odds of attrition among arrested college students.

Cardiac Arrest during Hospitalization for Delivery in the United States, 1998–2011

PubMed Central

Mhyre, Jill M.; Tsen, Lawrence C.; Einav, Sharon; Kuklina, Elena V.; Leffert, Lisa R.; Bateman, Brian T.

2015-01-01

Background The objective of this analysis was to evaluate the frequency, distribution of potential etiologies, and survival rates of maternal cardiopulmonary arrest during the hospitalization for delivery in the United States. Methods By using data from the Nationwide Inpatient Sample during the years 1998 through 2011, the authors obtained weighted estimates of the number of U.S. hospitalizations for delivery complicated by maternal cardiac arrest. Clinical and demographic risk factors, potential etiologies, and outcomes were identified and compared in women with and without cardiac arrest. The authors tested for temporal trends in the occurrence and survival associated with maternal arrest. Results Cardiac arrest complicated 1 in 12,000 or 8.5 per 100,000 hospitalizations for delivery (99% CI, 7.7 to 9.3 per 100,000). The most common potential etiologies of arrest included hemorrhage, heart failure, amniotic fluid embolism, and sepsis. Among patients with cardiac arrest, 58.9% of patients (99% CI, 54.8 to 63.0%) survived to hospital discharge. Conclusions Approximately 1 in 12,000 hospitalizations for delivery is complicated by cardiac arrest, most frequently due to hemorrhage, heart failure, amniotic fluid embolism, or sepsis. Survival depends on the underlying etiology of arrest. PMID:24694844

Characterizing cardiac arrest in children undergoing cardiac surgery: A single-center study.

PubMed

Gupta, Punkaj; Wilcox, Andrew; Noel, Tommy R; Gossett, Jeffrey M; Rockett, Stephanie R; Eble, Brian K; Rettiganti, Mallikarjuna

2017-02-01

To characterize cardiac arrest in children undergoing cardiac surgery using single-center data from the Society of Thoracic Surgeons and Pediatric Advanced Life Support Utstein-Style Guidelines. Patients aged 18 years or less having a cardiac arrest for 1 minute or more during the same hospital stay as heart operation qualified for inclusion (2002-2014). Patients having a cardiac arrest both before or after heart operation were included. Heart operations were classified on the basis of the first cardiovascular operation of each hospital admission (the index operation). The primary outcome was survival to hospital discharge. A total of 3437 children undergoing at least 1 heart operation were included. Overall rate of cardiac arrest among these patients was 4.5% (n = 154) with survival to hospital discharge of 84 patients (66.6%). Presurgery cardiac arrest was noted among 28 patients, with survival of 21 patients (75%). Among the 126 patients with postsurgery cardiac arrest, survival was noted among 84 patients (66.6%). Regardless of surgical case complexity, the median days between heart operation and cardiac arrest, duration of cardiac arrest, and survival after cardiac arrest were similar. The independent risk factors associated with improved chances of survival included shorter duration of cardiac arrest (odds ratio, 1.12; 95% confidence interval, 1.05-1.20; P = .01) and use of defibrillator (odds ratio, 4.51; 95% confidence interval, 1.08-18.87; P = .03). This single-center study demonstrates that characterizing cardiac arrest in children undergoing cardiac surgery using definitions from 2 societies helps to increase data granularity and understand the relationship between cardiac arrest and heart operation in a better way. Copyright © 2016 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

Distinct mechanisms act in concert to mediate cell cycle arrest.

PubMed

Toettcher, Jared E; Loewer, Alexander; Ostheimer, Gerard J; Yaffe, Michael B; Tidor, Bruce; Lahav, Galit

2009-01-20

In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfill at least 3 requirements: it must be activated promptly; it must be sustained as long as damage is present to prevent loss of genomic information; and after the arrest, cells must re-enter into the appropriate cell cycle phase to ensure proper ploidy. Multiple molecular mechanisms capable of arresting the cell cycle have been identified in mammalian cells; however, it is unknown whether each mechanism meets all 3 requirements or whether they act together to confer specific functions to the arrest. To address this question, we integrated mathematical models describing the cell cycle and the DNA damage signaling networks and tested the contributions of each mechanism to cell cycle arrest and re-entry. Predictions from this model were then tested with quantitative experiments to identify the combined action of arrest mechanisms in irradiated cells. We find that different arrest mechanisms serve indispensable roles in the proper cellular response to DNA damage over time: p53-independent cyclin inactivation confers immediate arrest, whereas p53-dependent cyclin downregulation allows this arrest to be sustained. Additionally, p21-mediated inhibition of cyclin-dependent kinase activity is indispensable for preventing improper cell cycle re-entry and endoreduplication. This work shows that in a complex signaling network, seemingly redundant mechanisms, acting in a concerted fashion, can achieve a specific cellular outcome.

Risk for Arrest: The Role of Social Bonds in Protecting Foster Youth Making the Transition to Adulthood

PubMed Central

Cusick, Gretchen Ruth; Havlicek, Judy R.; Courtney, Mark E.

2012-01-01

This study examines a sample of foster youth at the onset of the transition to adulthood and explores how social bonds are related to the risk of arrest during adulthood. Drawing from official arrest records, event history models are used to examine the time to arrest. Because individuals may be at risk for different types of crime, competing risk regression models are used to distinguish among arrests for drug-related, nonviolent, or violent crimes. Between the ages of 17–18 and 24, 46% of former foster youth experience an arrest. Arrests were evenly distributed across drug, nonviolent, and violent crimes columns. Although findings fail to support the significance of social bonds to interpersonal domains, bonds to employment and education are associated with a lower risk for arrest. Child welfare policy and practice implications for building connections and protections around foster youth are discussed. PMID:22239390

WE-H-201-00: Opportunities for Physicists to Support Low and Mid-Income Countries

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved. This session will help to explain the specific ways that Medical Physicists can uniquely assistmore » in this grand effort to help bring radiotherapy to grossly-underserved areas. Not only can these experts fulfill an important purpose, they also can benefit professionally, academically, emotionally and socially from the endeavor. By assisting others worldwide with their skillset, Medical Physicists can end up helping themselves. Learning Objectives: Understand the need for radiotherapy in LMICs. Understand which agencies are seeking Medical Physicists for help in LMICs. Understand the potential research funding mechanisms are available to establish academic collaborations with LMIC researchers/physicians. Understand the potential social and emotional benefits for both the physicist and the LMIC partners when collaborations are made. Understand the potential for collaboration with other high-income scientists that can develop as the physicist partners with other large institutions to assist LMICs. Wil Ngwa - A recent United Nations Study reports that in developing countries more people have access to cell phones than toilets. In Africa, only 63% of the population has access to piped water, yet, 93% of Africans have cell phone service. Today, these cell phones, Skype, WhatsApp and other information and communication technologies (ICTs) connect us in unprecedented ways and are increasingly recognized as powerful, indispensable to global health. Thanks to ICTs, there are growing opportunities for Medical Physicists to reach out beyond the bunker and impact the world far beyond, without even having to travel. These growing opportunities in global health for Medical Physicists, powered by ICTs, will be highlighted in this presentation, illustrated by high impact examples/models across the globe that are improving patient safety and healthcare outcomes, saving lives. Learning Objectives: Published definitions of global health and the emerging field of global radiation oncology Learn about the transformative potential of ICTs in global radiation oncology care, research and education with focus on Medical Physics Learn about high impact examples of ICT-powered global radiation oncology and the increasing opportunities for participation by Medical Physicists. Yakov Pipman - The number and scope of volunteer Medical Physics activities in support of low-to-middle income countries has been increasing gradually. This happens through a variety of formal channels and to some extent through less formal but personal initiatives. A good deal of effort is dedicated by many, but many more could be recruited through a structured framework to volunteer. We will look into typical volunteer activities and how they fit with organizations already involved in advancing Medical Physics in LMIC. We will identify the range of these organizational activities and their scope to reveal areas of further need. We will point to a few key features of MPWB ( http://www.mpwb.org ) as a volunteering and collaborating structure and how members can get involved and contribute to these efforts at the grass roots level. The goal is that scarce resources can thus be channeled to complement rather than compete with those already in place. Learning Objectives: Understand the strengths and limitations of various organizations that support Medical Physics efforts in LMIC. Learn about ways to volunteer and contribute to Global Health through a grass roots organization focused on Medical Physics in LMIC. Perry Sprawls - With the growing capability and complexity of medical imaging methods in all countries of the world, the expanding role of medical physicists includes optimizing imaging procedures with respect to image quality, radiation dose, and other conflicting factors. With access to appropriate educational resources local medical physicists in all countries can provide direct clinical support and educational for other medical professionals. This is being supported through the process of Collaborative Teaching that combines the capabilities and experience of medical physicists in countries spanning the spectrum of economic, technological, and clinical development. The supporting resources are on the web at: http://www.sprawls.org/resources . Learning Objectives: Identify the medical physics educational needs to support effective and optimized medical imaging procedures. Use collaborative teaching resources to enhance the role of medical physicists in all countries of the world.« less

WE-H-201-02: Emerging Models and Opportunities in Global Health for Medical Physicists Powered by Information and Communication Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ngwa, W.

The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved. This session will help to explain the specific ways that Medical Physicists can uniquely assistmore » in this grand effort to help bring radiotherapy to grossly-underserved areas. Not only can these experts fulfill an important purpose, they also can benefit professionally, academically, emotionally and socially from the endeavor. By assisting others worldwide with their skillset, Medical Physicists can end up helping themselves. Learning Objectives: Understand the need for radiotherapy in LMICs. Understand which agencies are seeking Medical Physicists for help in LMICs. Understand the potential research funding mechanisms are available to establish academic collaborations with LMIC researchers/physicians. Understand the potential social and emotional benefits for both the physicist and the LMIC partners when collaborations are made. Understand the potential for collaboration with other high-income scientists that can develop as the physicist partners with other large institutions to assist LMICs. Wil Ngwa - A recent United Nations Study reports that in developing countries more people have access to cell phones than toilets. In Africa, only 63% of the population has access to piped water, yet, 93% of Africans have cell phone service. Today, these cell phones, Skype, WhatsApp and other information and communication technologies (ICTs) connect us in unprecedented ways and are increasingly recognized as powerful, indispensable to global health. Thanks to ICTs, there are growing opportunities for Medical Physicists to reach out beyond the bunker and impact the world far beyond, without even having to travel. These growing opportunities in global health for Medical Physicists, powered by ICTs, will be highlighted in this presentation, illustrated by high impact examples/models across the globe that are improving patient safety and healthcare outcomes, saving lives. Learning Objectives: Published definitions of global health and the emerging field of global radiation oncology Learn about the transformative potential of ICTs in global radiation oncology care, research and education with focus on Medical Physics Learn about high impact examples of ICT-powered global radiation oncology and the increasing opportunities for participation by Medical Physicists. Yakov Pipman - The number and scope of volunteer Medical Physics activities in support of low-to-middle income countries has been increasing gradually. This happens through a variety of formal channels and to some extent through less formal but personal initiatives. A good deal of effort is dedicated by many, but many more could be recruited through a structured framework to volunteer. We will look into typical volunteer activities and how they fit with organizations already involved in advancing Medical Physics in LMIC. We will identify the range of these organizational activities and their scope to reveal areas of further need. We will point to a few key features of MPWB ( http://www.mpwb.org ) as a volunteering and collaborating structure and how members can get involved and contribute to these efforts at the grass roots level. The goal is that scarce resources can thus be channeled to complement rather than compete with those already in place. Learning Objectives: Understand the strengths and limitations of various organizations that support Medical Physics efforts in LMIC. Learn about ways to volunteer and contribute to Global Health through a grass roots organization focused on Medical Physics in LMIC. Perry Sprawls - With the growing capability and complexity of medical imaging methods in all countries of the world, the expanding role of medical physicists includes optimizing imaging procedures with respect to image quality, radiation dose, and other conflicting factors. With access to appropriate educational resources local medical physicists in all countries can provide direct clinical support and educational for other medical professionals. This is being supported through the process of Collaborative Teaching that combines the capabilities and experience of medical physicists in countries spanning the spectrum of economic, technological, and clinical development. The supporting resources are on the web at: http://www.sprawls.org/resources . Learning Objectives: Identify the medical physics educational needs to support effective and optimized medical imaging procedures. Use collaborative teaching resources to enhance the role of medical physicists in all countries of the world.« less

WE-H-201-04: Models for Developing Medical Physics Educators and Education Programs in the Developing Countries and the Potential Role of US Universities and Individual Medical Physicists

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sprawls, P.

The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved. This session will help to explain the specific ways that Medical Physicists can uniquely assistmore » in this grand effort to help bring radiotherapy to grossly-underserved areas. Not only can these experts fulfill an important purpose, they also can benefit professionally, academically, emotionally and socially from the endeavor. By assisting others worldwide with their skillset, Medical Physicists can end up helping themselves. Learning Objectives: Understand the need for radiotherapy in LMICs. Understand which agencies are seeking Medical Physicists for help in LMICs. Understand the potential research funding mechanisms are available to establish academic collaborations with LMIC researchers/physicians. Understand the potential social and emotional benefits for both the physicist and the LMIC partners when collaborations are made. Understand the potential for collaboration with other high-income scientists that can develop as the physicist partners with other large institutions to assist LMICs. Wil Ngwa - A recent United Nations Study reports that in developing countries more people have access to cell phones than toilets. In Africa, only 63% of the population has access to piped water, yet, 93% of Africans have cell phone service. Today, these cell phones, Skype, WhatsApp and other information and communication technologies (ICTs) connect us in unprecedented ways and are increasingly recognized as powerful, indispensable to global health. Thanks to ICTs, there are growing opportunities for Medical Physicists to reach out beyond the bunker and impact the world far beyond, without even having to travel. These growing opportunities in global health for Medical Physicists, powered by ICTs, will be highlighted in this presentation, illustrated by high impact examples/models across the globe that are improving patient safety and healthcare outcomes, saving lives. Learning Objectives: Published definitions of global health and the emerging field of global radiation oncology Learn about the transformative potential of ICTs in global radiation oncology care, research and education with focus on Medical Physics Learn about high impact examples of ICT-powered global radiation oncology and the increasing opportunities for participation by Medical Physicists. Yakov Pipman - The number and scope of volunteer Medical Physics activities in support of low-to-middle income countries has been increasing gradually. This happens through a variety of formal channels and to some extent through less formal but personal initiatives. A good deal of effort is dedicated by many, but many more could be recruited through a structured framework to volunteer. We will look into typical volunteer activities and how they fit with organizations already involved in advancing Medical Physics in LMIC. We will identify the range of these organizational activities and their scope to reveal areas of further need. We will point to a few key features of MPWB ( http://www.mpwb.org ) as a volunteering and collaborating structure and how members can get involved and contribute to these efforts at the grass roots level. The goal is that scarce resources can thus be channeled to complement rather than compete with those already in place. Learning Objectives: Understand the strengths and limitations of various organizations that support Medical Physics efforts in LMIC. Learn about ways to volunteer and contribute to Global Health through a grass roots organization focused on Medical Physics in LMIC. Perry Sprawls - With the growing capability and complexity of medical imaging methods in all countries of the world, the expanding role of medical physicists includes optimizing imaging procedures with respect to image quality, radiation dose, and other conflicting factors. With access to appropriate educational resources local medical physicists in all countries can provide direct clinical support and educational for other medical professionals. This is being supported through the process of Collaborative Teaching that combines the capabilities and experience of medical physicists in countries spanning the spectrum of economic, technological, and clinical development. The supporting resources are on the web at: http://www.sprawls.org/resources . Learning Objectives: Identify the medical physics educational needs to support effective and optimized medical imaging procedures. Use collaborative teaching resources to enhance the role of medical physicists in all countries of the world.« less

Epidemiology and outcomes of cardiac arrest among children with Down Syndrome: a multicenter analysis.

PubMed

Padiyath, Asif; Rettiganti, Mallikarjuna; Gossett, Jeffrey M; Tadphale, Sachin D; Garcia, Xiomara; Seib, Paul M; Gupta, Punkaj

2017-06-01

With the increasing prevalence of Down Syndrome, it is unknown if children with Down Syndrome are associated with increased incidence of cardiac arrest and poor outcomes after cardiac arrest. The objective of this study was to evaluate the epidemiology of cardiac arrest and mortality after cardiac arrest among critically ill children with and without Down Syndrome. Patients ≤18 years admitted at a Pediatric Health Information Systems (PHIS) participating Intensive Care Unit were included (2004-2014). Multivariable logistic regression models were fitted to evaluate association of Down Syndrome with study outcomes after adjusting for patient and center characteristics. A total of 849,250 patients from 44 centers were included. Of the 25,143 patients with Down Syndrome, cardiac arrest was noted among 568 (2.3%) patients with an associated mortality at hospital discharge of 248 (43.6%) patients. In contrast, of the 824,107 patients without Down Syndrome, cardiac arrest was noted among 15,822 (1.9%) patients with an associated mortality at hospital discharge of 7775 (49.1%) patients. In adjusted models, patients with Down Syndrome had a higher likelihood of having cardiac arrest as compared to patients without Down Syndrome (with vs. without Down, OR: 1.14, 95% CI: 1.03-1.25, P=0.01). Despite having a higher likelihood of cardiac arrest, patients with Down Syndrome were associated with a lower mortality after cardiac arrest (OR: 0.78, 95% CI: 0.63-0.96, P=0.02). Both incidence of cardiac arrest, and mortality at hospital discharge in those with cardiac arrest vary substantially in children with and without Down Syndrome.

Physicists' Forced Migrations under Hitler

NASA Astrophysics Data System (ADS)

Beyerchen, Alan

2011-03-01

When the Nazis came to power in early 1933 they initiated formal and informal measures that forced Jews and political opponents from public institutions such as universities. Some physicists retired and others went into industry, but most emigrated. International communication and contact made emigration a viable option despite the desperate economic times in the Great Depression. Another wave of emigrations followed the annexation of Austria in 1938. Individual cases as well as general patterns of migration and adaptation to new environments will be examined in this presentation. One important result of the forced migrations was that many of the physicists expelled under Hitler played important roles in strengthening physics elsewhere, often on the Allied side in World War II.

Physicists in the Wild

NASA Astrophysics Data System (ADS)

Miller, Michael L.

2017-09-01

Startups and large corporations are full of physicists, many hiding in plain sight. Why? I will discuss the strong parallels between basic research in nuclear/particle physics, founding teams at great startups, and leaders at some of the world's largest corporations. How big are these opportunities (mission and capital), and what can we do to help prepare more physicists for such roles? I will provide lessons learned from my winding career that began at the NSCL as a philosophy undergrad, proceeded through a PhD, postdoc and brief stint as faculty, and continued through the founding of an early cloud computing startup, a sale to IBM, and the founding of one of Silicon Valley's most active venture capital firms.

Rejoice in the hubris: useful things biologists could do for physicists

NASA Astrophysics Data System (ADS)

Austin, Robert H.

2014-10-01

Political correctness urges us to state how wonderful it is to work with biologists and how, just as the lion will someday lie down with the lamb, so will interdisciplinary work, where biologists and physicists are mixed together in light, airy buildings designed to force socialization, give rise to wonderful new science. But it has been said that the only drive in human nature stronger than the sex drive is the drive to censor and suppress, and so I claim that it is OK for physicists and biologists to maintain a wary distance from each other, so that neither one censors or suppresses the wild ideas of the other.

The rationale behind Pierre Duhem's natural classification.

PubMed

Bhakthavatsalam, Sindhuja

2015-06-01

The central concern of this paper is the interpretation of Duhem's attitude towards physical theory. Based on his view that the classification of experimental laws yielded by theory progressively approaches a natural classification-a classification reflecting that of underlying realities-Duhem has been construed as a realist of sorts in recent literature. Here I argue that his positive attitude towards the theoretic classification of laws had rather to do with the pragmatic rationality of the physicist. Duhem's idea of natural classification was an intuitive idea in the mind of the physicist that had to be affirmed in order to justify the physicist's pursuit of theory. Copyright © 2015 Elsevier Ltd. All rights reserved.

AFOMP Policy No 5: career progression for clinical medical physicists in AFOMP countries.

PubMed

Round, W H; Stefanoyiannis, A P; Ng, K H; Rodriguez, L V; Thayalan, K; Han, Y; Tang, F; Fukuda, S; Srivastava, R; Krisanachinda, A; Shiau, A C; Deng, X

2015-06-01

This policy statement, which is the fifth of a series of documents being prepared by the Asia-Oceania Federation of Organizations for Medical Physics Professional Development Committee, gives guidance on how clinical medical physicists' careers should progress from their initial training to career end. It is not intended to be prescriptive as in some AFOMP countries career structures are already essentially defined by employment awards and because such matters will vary considerably from country to country depending on local culture, employment practices and legislation. It is intended to be advisory and set out options for member countries and employers of clinical medical physicists to develop suitable career structures.

Mid-Career PhD Physicists: Academia & Beyond

NASA Astrophysics Data System (ADS)

White, Susan

2017-01-01

What jobs do mid-career PhD physicists hold? In a first-ever study, we collected data in 2011 from over 1,500 physics PhD recipients from the classes of 1996, 1997, 2000, and 2001. About 45% of the physics PhD recipients in these classes immediately took jobs that were not temporary, and over 40% accepted postdocs. How does taking a postdoc affect mid-career employment? What is the relationship between first job (after any postdocs) and mid-career employment? How do physicists' actual jobs compare with what they thought they would be doing when they graduated? Using our initial employment and mid-career data, I will answer these questions and more.

Rejoice in the hubris: useful things biologists could do for physicists.

PubMed

Austin, Robert H

2014-10-08

Political correctness urges us to state how wonderful it is to work with biologists and how, just as the lion will someday lie down with the lamb, so will interdisciplinary work, where biologists and physicists are mixed together in light, airy buildings designed to force socialization, give rise to wonderful new science. But it has been said that the only drive in human nature stronger than the sex drive is the drive to censor and suppress, and so I claim that it is OK for physicists and biologists to maintain a wary distance from each other, so that neither one censors or suppresses the wild ideas of the other.

The development and implementation of cardiac arrest centers.

PubMed

Donnino, Michael W; Rittenberger, Jon C; Gaieski, David; Cocchi, Michael N; Giberson, Brandon; Peberdy, Mary Ann; Abella, Benjamin S; Bobrow, Bentley J; Callaway, Clifton

2011-08-01

In the last decade, many regionalized centers for the care of post-cardiac arrest patients (cardiac arrest centers) have all independently developed with a common goal of providing multi-disciplinary and organized care plans for this patient population. The American Heart Association recently issued support for regionalized and organized comprehensive care for post-arrest patients through a position paper as well as the 2010 American Heart Association BLS/ACLS guidelines. This paper outlines the formation, structure, and implementation of four cardiac arrest centers, and also discusses a statewide model of post-arrest center care. This paper may assist other potential clinical sites that are considering or actively developing cardiac arrest centers of their own. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Arrest and incarceration of civil commitment candidates.

PubMed

Hiday, V A

1991-07-01

To gauge whether more stringent civil commitment criteria have led to the criminalization of mentally ill persons, forcing them into jails and prisons instead of treating them, a statewide sample of 1,226 civil commitment candidates in North Carolina was tracked for six months after their commitment hearings. Only 72 sample members were arrested during the period, mostly for burglary or larceny (22 arrests), simple or aggravated assault (17 arrests), and minor offenses (40 arrests), including drunkenness, trespassing, and traffic violations. Fourteen sample members were jailed, and two were sent to prison. The mentally ill who were not involuntarily hospitalized or who were hospitalized for only short periods were seldom arrested; when they were arrested, the charges were generally for nondangerous offenses.

Same-Sex and Race-Based Disparities in Statutory Rape Arrests.

PubMed

Chaffin, Mark; Chenoweth, Stephanie; Letourneau, Elizabeth J

2016-01-01

This study tests a liberation hypothesis for statutory rape incidents, specifically that there may be same-sex and race/ethnicity arrest disparities among statutory rape incidents and that these will be greater among statutory rape than among forcible sex crime incidents. 26,726 reported incidents of statutory rape as defined under state statutes and 96,474 forcible sex crime incidents were extracted from National Incident-Based Reporting System data sets. Arrest outcomes were tested using multilevel modeling. Same-sex statutory rape pairings were rare but had much higher arrest odds. A victim-offender romantic relationship amplified arrest odds for same-sex pairings, but damped arrest odds for male-on-female pairings. Same-sex disparities were larger among statutory than among forcible incidents. Female-on-male incidents had uniformly lower arrest odds. Race/ethnicity effects were smaller than gender effects and more complexly patterned. The findings support the liberation hypothesis for same-sex statutory rape arrest disparities, particularly among same-sex romantic pairings. Support for race/ethnicity-based arrest disparities was limited and mixed. © The Author(s) 2014.

Williams Holistic Approach Model (WHAM): Sustainable University Leadership from the Perspective of a Woman Physicist

ERIC Educational Resources Information Center

Williams, Elvira S.

2010-01-01

University leadership from career and organizational viewpoints are discussed from the perspective of a woman physicist. Laws of physics are used, through appropriate analogies, as templates for structuring useful life lessons on holistic WHAM leadership. Interactive university skill sets and program policies based on holistic WHAM approaches are…

Why Aren’t Lightsabers Real Yet? Get the Lowdown from a Laser Physicist

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunsberger, Maren; Liao, Zhi

The release of "Star Wars: The Force Awakens" begs the obvious question: Why aren't lightsabers real yet? LLNL science communicator Maren Hunsberger gets the lowdown from laser physicist Zhi Liao in this first installment of "Inside the Lab," a new YouTube series exploring crazy-cool science questions.

My Collaboration with Cuban Physicists

NASA Astrophysics Data System (ADS)

Leccabue, Fabrizio

My first meeting with the scientific Cuban community was in 1969 when the first of four young Cuban physicists, Joaquín Torres Orosco†, came to the Physics Department of Parma University through the `Andrea Levialdi Fellowship,' an Italian bursary promoted by Roberto Fieschi using a fund, subscribed to voluntarily by the Italian physics community.

No Space for Girliness in Physics: Understanding and Overcoming the Masculinity of Physics

ERIC Educational Resources Information Center

Götschel, Helene

2014-01-01

Allison Gonsalves' article on "women doctoral students' positioning around discourses of gender and competence in physics" explores narratives of Canadian women physicists concerning their strategies to gain recognition as physicists. In my response to her rewarding and inspiring analysis I will reflect on her findings and arguments and…

Mathematics for Physicists and Engineers.

ERIC Educational Resources Information Center

Organisation for Economic Cooperation and Development, Paris (France).

The text is a report of the OEEC Seminar on "The Mathematical Knowledge Required by the Physicist and Engineer" held in Paris, 1961. There are twelve major papers presented: (1) An American Parallel (describes the work of the Panel on Physical Sciences and Engineering of the Committee on the Undergraduate Program in Mathematics of the Mathematical…

You Don't Look Like a Physicist

ERIC Educational Resources Information Center

Santos, Antonio Carlos Fontes

2017-01-01

"You don't look like a physicist!" "Sorry, this bus only goes to the university, Sir." "Where are you going, sir?" "So, you are a university professor? But a substitute one, aren't you?" "OK, you're a professor, but do you do research?" As a person of color teaching physics in Brazil, those are…

Thoughts of Modern Women in Physics

ERIC Educational Resources Information Center

Ainsbury, Liz; Heaney, Libby; Hodges, Vicki; Harkness, Laura; Russell, Laura

2011-01-01

In 2007, the Women in Physics Group of the Institute of Physics initiated the Very Early Career Woman Physicist of the Year Award. The award seeks to recognise the outstanding achievements of women physicists who are embarking on a career in physics and to promote the career opportunities open to people with physics qualifications. The prize is…

Collaborative Lab Reports with Google Docs

ERIC Educational Resources Information Center

Wood, Michael

2011-01-01

Science is a collaborative endeavor. The solitary genius working on the next great scientific breakthrough is a myth not seen much today. Instead, most physicists have worked in a group at one point in their careers, whether as a graduate student, faculty member, staff scientist, or industrial researcher. As an experimental nuclear physicist with…

"Angels & Demons" May Help Physicists Explain What Matters

ERIC Educational Resources Information Center

Basken, Paul

2009-01-01

It's not every day that scientific researchers need to defend themselves against charges of destroying humanity. And yet a group of several dozen physicists associated with the Large Hadron Collider may be getting pretty good at it--and, at the same time, actively engaging in public education and debate in ways that university scientists have…

Factors Influencing International PhD Students to Study Physics in Australia

ERIC Educational Resources Information Center

Choi, Serene H.-J.; Nieminen, Timo A.; Townson, Peter

2012-01-01

Since physics research is an activity of an active international community, international visits are a common way for physicists to share scientific knowledge and skills. International mobility of physicists is also important for PhD physics study and research training. We investigated personal and social factors that influenced the decision for…

Fireworks on the 4th of July

ERIC Educational Resources Information Center

Barnett, R. Michael

2013-01-01

After half a century of waiting, the drama was intense. Physicists slept overnight outside the auditorium to get seats for the seminar at the CERN lab in Geneva, Switzerland. Ten thousand miles away on the other side of the planet, at the world's most prestigious international particle physics conference, hundreds of physicists from every corner…

Predicting Arrest in a Sample of Youth Perinatally Exposed to HIV: The Intersection of HIV and Key Contextual Factors.

PubMed

Elkington, Katherine S; Peters, Zachary; Choi, C Jean; Bucek, Amelia; Leu, Cheng-Shiun; Abrams, Elaine J; Mellins, Claude A

2017-11-22

We examined the role of youth HIV status and other key factors on past-year arrest in perinatally HIV-exposed but uninfected (PHIV-) and perinatally HIV-infected (PHIV+) youth using data from a multi-site study of psychosocial behaviors in PHIV-exposed urban youth (N = 340; 61% PHIV+; 51% female; ages 9-16 at baseline). Youth and caregivers were administered 5 interviews, spanning approximately 7.5 years. Using longitudinal logistic mixed-effect models, we explored the association between past year arrest, internal [e.g., substance use disorder (SUD)] and external (e.g., neighborhood arrest rates) contextual factors, and social-regulation processes (e.g., in-school/work). Arrest rates increased from 2.6 to 19.7% across follow-ups; there were no differences in arrest over time by HIV status. In the final model, odds of arrest were greater for youth who were male, with SUD, ≥ 18 years old, with high levels of city stress, and neither in school nor employed. PHIV-exposed, urban youth have much higher rates of arrest than national samples. Lack of differences in arrest by HIV status suggests key contextual factors are more important in promoting arrest.

Can Industrial Physics Avoid Being Creatively Destroyed?

NASA Astrophysics Data System (ADS)

Hass, Kenneth C.

2004-03-01

Opportunities abound for physics and physicists to remain vital contributors to industrial innovation throughout the 21st century. The key questions are whether those trained in physics are sufficiently willing and flexible to continuously enhance their value to their companies by adapting to changing business priorities and whether business leaders are sufficiently enlightened to recognize and exploit the unique skills and creativity that physicists often provide. "Industrial physics" today is more diverse than ever, and answers to the above questions will vary with sector, company, and even individual physicists. Such heterogeneity creates new challenges for the physics community in general, which may need to undergo significant cultural change to maintain strong ties between physicists in industry, academia, and government. Insights from the emerging science of complex systems will be used to emphasize the importance of realistic mental models for the interactions between science and technology and the pathways from scientific advance to successful commercialization. Examples will be provided of the ongoing value of physics-based research in the auto industry and of the growing importance of interdisciplinary approaches to the technical needs of industry.

Medical Physicists and AAPM

NASA Astrophysics Data System (ADS)

Amols, Howard

2006-03-01

The American Association of Physicists in Medicine (AAPM), a member society of the AIP is the largest professional society of medical physicists in the world with nearly 5700 members. Members operate in medical centers, university and community hospitals, research laboratories, industry, and private practice. Medical physics specialties include radiation therapy physics, medical diagnostic and imaging physics, nuclear medicine physics, and medical radiation safety. The majority of AAPM members are based in hospital departments of radiation oncology or radiology and provide technical support for patient diagnosis and treatment in a clinical environment. Job functions include support of clinical care, calibration and quality assurance of medical devices such as linear accelerators for cancer therapy, CT, PET, MRI, and other diagnostic imaging devices, research, and teaching. Pathways into a career in medical physics require an advanced degree in medical physics, physics, engineering, or closely related field, plus clinical training in one or more medical physics specialties (radiation therapy physics, imaging physics, or radiation safety). Most clinically based medical physicists also obtain certification from the American Board of Radiology, and some states require licensure as well.

Careers in Medical Physics and the American Association of Physicists in Medicine

NASA Astrophysics Data System (ADS)

Amols, Howard

2006-03-01

The American Association of Physicists in Medicine (AAPM), a member society of the AIP is the largest professional society of medical physicists in the world with nearly 5700 members. Members operate in medical centers, university and community hospitals, research laboratories, industry, and private practice. Medical physics specialties include radiation therapy physics, medical diagnostic and imaging physics, nuclear medicine physics, and medical radiation safety. The majority of AAPM members is based in hospital departments of radiation oncology or radiology and provide technical support for patient diagnosis and treatment in a clinical environment. Job functions include support of clinical care, calibration and quality assurance of medical devices such as linear accelerators for cancer therapy, CT, PET, MRI, and other diagnostic imaging devices, research, and teaching. Pathways into a career in medical physics require an advanced degree in medical physics, physics, engineering, or closely related field, plus clinical training in one or more medical physics specialties (radiation therapy physics, imaging physics, or radiation safety). Most clinically based medical physicists also obtain certification from the American Board of Radiology, and some states require licensure as well.

Physics is …; The Physicist explores attributes of physics

NASA Astrophysics Data System (ADS)

Baker, F. Todd

2016-12-01

He's back! 'The physicist'returns with an entirely new compilation of questions and answers from his long-lived website where laypeople can ask questions about anything physics related. This book focuses on adjectives (practical, beautiful, surprising, cool, frivolous) instead of nouns like the first two books (atoms, photons, quanta, mechanics, relativity). The answers within 'Physics Is' are responses to people looking for answers to fascinating (and often uninformed) questions. It covers topics such as sports, electromagnetism, gravitational theory, special relativity, superheroes, videogames, and science fiction. These books are designed for laypeople and rely heavily on concepts rather than formalism. That said, they keep the physics correct and don't water down, so expert physicists will find this book and its two companion titles fun reads. They may actually recognize similar questions posed to them by friends and family. As with the first two books, 'Physics Is' ends with a chapter with questions from people who think that 'The physicist' is a psychic and from people who think they have the answers to life, the universe and everything.

The role of medical physics in prostate cancer radiation therapy.

PubMed

Fiorino, Claudio; Seuntjens, Jan

2016-03-01

Medical physics, both as a scientific discipline and clinical service, hugely contributed and still contributes to the advances in the radiotherapy of prostate cancer. The traditional translational role in developing and safely implementing new technology and methods for better optimizing, delivering and monitoring the treatment is rapidly expanding to include new fields such as quantitative morphological and functional imaging and the possibility of individually predicting outcome and toxicity. The pivotal position of medical physicists in treatment personalization probably represents the main challenge of current and next years and needs a gradual change of vision and training, without losing the traditional and fundamental role of physicists to guarantee a high quality of the treatment. The current focus issue is intended to cover traditional and new fields of investigation in prostate cancer radiation therapy with the aim to provide up-to-date reference material to medical physicists daily working to cure prostate cancer patients. The papers presented in this focus issue touch upon present and upcoming challenges that need to be met in order to further advance prostate cancer radiation therapy. We suggest that there is a smart future for medical physicists willing to perform research and innovate, while they continue to provide high-quality clinical service. However, physicists are increasingly expected to actively integrate their implicitly translational, flexible and high-level skills within multi-disciplinary teams including many clinical figures (first of all radiation oncologists) as well as scientists from other disciplines. Copyright © 2016. Published by Elsevier Ltd.

Using non-specialist observers in 4AFC human observer studies

NASA Astrophysics Data System (ADS)

Elangovan, Premkumar; Mackenzie, Alistair; Dance, David R.; Young, Kenneth C.; Wells, Kevin

2017-03-01

Virtual clinical trials (VCTs) are an emergent approach for rapid evaluation and comparison of various breast imaging technologies and techniques using computer-based modeling tools. Increasingly 4AFC (Four alternative forced choice) virtual clinical trials are used to compare detection performances of different breast imaging modalities. Most prior studies have used physicists and/or radiologists and physicists interchangeably. However, large scale use of statistically significant 4AFC observer studies is challenged by the individual time commitment and cost of such observers, often drawn from a limited local pool of specialists. This work aims to investigate whether non-specialist observers can be used to supplement such studies. A team of five specialist observers (medical physicists) and five non-specialists participated in a 4AFC study containing simulated 2D-mammography and DBT (digital breast tomosynthesis) images, produced using the OPTIMAM toolbox for VCTs. The images contained 4mm irregular solid masses and 4mm spherical targets at a range of contrast levels embedded in a realistic breast phantom background. There was no statistically significant difference between the detection performance of medical physicists and non-specialists (p>0.05). However, non-specialists took longer to complete the study than their physicist counterparts, which was statistically significant (p<0.05). Overall, the results from both observer groups indicate that DBT has a lower detectable threshold contrast than 2D-mammography for both masses and spheres, and both groups found spheres easier to detect than irregular solid masses.

The Smallest Drops of the Hottest Matter? New Investigations at the Relativistic Heavy Ion Collider (493rd Brookhaven Lecture)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sickles, Anne

2014-03-19

Pool sharks at the billiards hall know that sometimes you aim to rocket the cue ball for a head-on collision, and other times, a mere glance will do. Physicists need to know more than a thing or two about collision geometry too, as they sift through data from the billions of ions that smash together at the Relativistic Heavy Ion Collider (RHIC). Determining whether ions crash head-on or just glance is crucial for the physicists analyzing data to study quark-gluon plasma—the ultra-hot, "perfect" liquid of quarks and gluons that existed more than 13 billion years ago, before the first protonsmore » and neutrons formed. For these physicists, collision geometry data provides insights about quark-gluon plasma's extremely low viscosity and other unusual properties, which are essential for understanding more about the "strong force" that holds together the nucleus, protons, and neutrons of every atom in the universe. Dr. Sickles explains how physicists use data collected at house-sized detectors like PHENIX and STAR to determine what happens before, during, and after individual particle collisions among billions at RHIC. She also explains how the ability to collide different "species" of nuclei at RHIC—including protons and gold ions today and possibly more with a proposed future electron-ion collider upgrade (eRHIC)—enables physicists to probe deeper into the mysteries of quark-gluon plasma and the strong force.« less

The medical physics specialization system in Poland.

PubMed

Bulski, Wojciech; Kukołowicz, Paweł; Skrzyński, Witold

2016-07-01

This paper presents the situation of the profession of medical physicists in Poland. The official recognition of the profession of medical physicist in Polish legislation was in 2002. In recent years, more and more Universities which have Physics Faculties introduce a medical physics specialty. At present, there are about 15 Universities which offer such programmes. These Universities are able to graduate about 150 medical physicists per year. In 2002, the Ministry of Health introduced a programme of postgraduate specialization in medical physics along the same rules employed in the specialization of physicians in various branches of medicine. Five institutions, mostly large oncology centres, were selected as teaching institutions, based on their experience, the quality of the medical physics professionals, staffing levels, equipment availability, lecture halls, etc. The first cycle of the specialization programme started in 2006, and the first candidates completed their training at the end of 2008, and passed their official state exams in May 2009. As of January 2016, there are 196 specialized medical physicists in Poland. Another about 120 medical physicists are undergoing specialization. The system of training of medical physics professionals in Poland is well established. The principles of postgraduate training and specialization are well defined and the curriculum of the training is very demanding. The programme of specialization was revised in 2011 and is in accordance with EC and EFOMP recommendations. Copyright © 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

The Rhetoric of Physics: AN Ethnography of the Research and Writing Processes in a Physics Laboratory.

NASA Astrophysics Data System (ADS)

Graves, Heather Ann Brodie

1992-01-01

This dissertation explores the extent to which rhetoric plays a role in the research and writing processes of physicists. It seeks to join the on-going conversation in the rhetoric of inquiry about the ways in which rhetorical forces shape all knowledge systems. Based on data collected during a six-month ethnography in a thin films laboratory, this study argues that these physicists use rhetoric in all stages of the knowledge creation process. After following the experimental process through all its stages from the inception of an experiment through to publication, this study maps out the types of heuristic devices employed by the physicists as they analyzed, interpreted, and presented their research data in a persuasive scientific article. In light of the insights gained from studying the dynamic interactions between physicists, this dissertation also comments on the theoretical and philosophical debates under discussion in the rhetoric of inquiry and the rhetoric of science. It examines current theories of language (as expressed by rhetoricians, critical theorists, and the physicists in this laboratory) to explore the relationship between reality and language, the role that rhetoric plays in knowledge creation in physics, and the ways in which reality and knowledge may be socially constructed. It concludes that these physicists use rhetorical invention strategies to interpret and present their data. It also argues that scientific knowledge is subject to rhetorical forces because it deals with contingent affairs--phenomena about which scientists advance propositions which appear to be true but about which there is no way to gain absolute certainty or truth. Finally, it concludes that rhetoric both is and is not epistemic in the physics research studied here, and it argues that instead of asking "Is rhetoric epistemic?" perhaps we might shift our attention to inquiring "When is rhetoric epistemic?".

SU-F-E-16: A Specific Training Package for Medical Physicists in Support to Nuclear and Radiological Emergency Situations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meghzifene, A; Berris, T

Purpose: To provide the professional medical physicists with adequate competencies and skills in order to help them get prepared to support Nuclear or Radiological Emergency (NRE) situations. Methods: Although clinical medical physicists working have in-depth knowledge in radiation dosimetry, including dose reconstruction and dose measurements, they are usually not involved in NRE situations. However, in a few instances where medical physicists were involved in NREs, it appeared that many lacked specific knowledge and skills that are required in such situations. This lack of specific knowledge and skills is probably due to the fact that most current medical physics curricula domore » not include a specific module on this topic. As a response to this finding, the IAEA decided to initiate a project to develop a specific training package to help prepare medical physicists to support NRE situations. The training package was developed with the kind support of the Government of Japan and in collaboration with Fukushima Medical University (FMU) and the National Institute of Radiological Sciences (NIRS). Results: The first International Workshop to test the training package was held in Fukushima, Japan in June 2015. It consisted of lectures, demonstrations, simulation, role play, and practical sessions followed by discussions. The training was delivered through 14 modules which were prepared with the support of 12 lecturers. A knowledge assessment test was done before the workshop, followed by the same test done at the end of the Workshop, to assess the knowledge acquired during the training. Conclusion: The Workshop was successfully implemented. The overall rating of the workshop by the participants was excellent and all participants reported that they acquired a good understanding of the main issues that are relevant to medical physics support in case of NRE situations. They are expected to disseminate the knowledge to other medical physicists in their countries.« less

TU-F-213AB-01: Diagnostic Workforce and Manpower Survey.

PubMed

Mills, M; Nickoloff, E

2012-06-01

Since AAPM Report No. 33 on Diagnostic Radiology Physics staffing is more than 20 years old, the Diagnostic Work and Workforce Study Subcommittee (DWWSS) of the Professional Council was formed to conduct a new study and update the data. The intent of the DWWSS study has two goals. First, it wanted to assess the number of FTE diagnostic physicists needed to support the QC, acceptance tests, radiation safety and other clinical functions for various imaging modalities, such as: CT scanners, MRI units, angiography rooms, ultrasound units, nuclear medicine imagers and other equipment. For example, the preliminary results indicate that the median annual physics support for one CT scanner is 0.007 FTE or 12.6 hours per unit. Second, the study wanted to provide an estimate of the cost of these physics services in terms of a fraction of a dollar per patient examination performed. For example, the cost for physics support of CT would be $0.27 for each CT procedure. This information would be similar to the Abt study conducted in Radiation Oncology. Radiation therapy physicists have utilized the Abt studies to generate re-imbursement for physics services and to justify financially the cost of their work efforts. Appropriate recognition for physics efforts in Diagnostic Radiology has never been properly quantified nor appreciated. With all the current and future changes occurring in healthcare, the information from the DWWSS survey could be important to the future of diagnostic physicists. Although diagnostic physicists are involved with many other activities such as teaching of residents and research, information about the clinical equipment support effort could be used to assess diagnostic physics staffing needs. The goals of the DWWSS study and the preliminary findings will be presented. 1. Present the goals of the DWWSS Diagnostic Physicist Survey.2. Present potential benefits to the AAPM members from this survey.3. Present findings from the preliminary analysis of the survey. © 2012 American Association of Physicists in Medicine.

The role of the health physicist in nuclear security.

PubMed

Waller, Edward J; van Maanen, Jim

2015-04-01

Health physics is a recognized safety function in the holistic context of the protection of workers, members of the public, and the environment against the hazardous effects of ionizing radiation, often generically designated as radiation protection. The role of the health physicist as protector dates back to the Manhattan Project. Nuclear security is the prevention and detection of, and response to, criminal or intentional unauthorized acts involving or directed at nuclear material, other radioactive material, associated facilities, or associated activities. Its importance has become more visible and pronounced in the post 9/11 environment, and it has a shared purpose with health physics in the context of protection of workers, members of the public, and the environment. However, the duties and responsibilities of the health physicist in the nuclear security domain are neither clearly defined nor recognized, while a fundamental understanding of nuclear phenomena in general, nuclear or other radioactive material specifically, and the potential hazards related to them is required for threat assessment, protection, and risk management. Furthermore, given the unique skills and attributes of professional health physicists, it is argued that the role of the health physicist should encompass all aspects of nuclear security, ranging from input in the development to implementation and execution of an efficient and effective nuclear security regime. As such, health physicists should transcend their current typical role as consultants in nuclear security issues and become fully integrated and recognized experts in the nuclear security domain and decision making process. Issues regarding the security clearances of health physics personnel and the possibility of insider threats must be addressed in the same manner as for other trusted individuals; however, the net gain from recognizing and integrating health physics expertise in all levels of a nuclear security regime far outweighs any negative aspects. In fact, it can be argued that health physics is essential in achieving an integrated approach toward nuclear safety, security, and safeguards.

The Role of the Health Physicist in Nuclear Security

PubMed Central

Waller, Edward J.; van Maanen, Jim

2015-01-01

Abstract Health physics is a recognized safety function in the holistic context of the protection of workers, members of the public, and the environment against the hazardous effects of ionizing radiation, often generically designated as radiation protection. The role of the health physicist as protector dates back to the Manhattan Project. Nuclear security is the prevention and detection of, and response to, criminal or intentional unauthorized acts involving or directed at nuclear material, other radioactive material, associated facilities, or associated activities. Its importance has become more visible and pronounced in the post 9/11 environment, and it has a shared purpose with health physics in the context of protection of workers, members of the public, and the environment. However, the duties and responsibilities of the health physicist in the nuclear security domain are neither clearly defined nor recognized, while a fundamental understanding of nuclear phenomena in general, nuclear or other radioactive material specifically, and the potential hazards related to them is required for threat assessment, protection, and risk management. Furthermore, given the unique skills and attributes of professional health physicists, it is argued that the role of the health physicist should encompass all aspects of nuclear security, ranging from input in the development to implementation and execution of an efficient and effective nuclear security regime. As such, health physicists should transcend their current typical role as consultants in nuclear security issues and become fully integrated and recognized experts in the nuclear security domain and decision making process. Issues regarding the security clearances of health physics personnel and the possibility of insider threats must be addressed in the same manner as for other trusted individuals; however, the net gain from recognizing and integrating health physics expertise in all levels of a nuclear security regime far outweighs any negative aspects. In fact, it can be argued that health physics is essential in achieving an integrated approach toward nuclear safety, security, and safeguards. PMID:25706142

Epidemiological characteristics of sudden cardiac arrest in schools.

PubMed

Nishiuchi, Tatsuya; Hayashino, Yasuaki; Iwami, Taku; Kitamura, Tetsuhisa; Nishiyama, Chika; Kajino, Kentaro; Nitta, Masahiko; Hayashi, Yasuyuki; Hiraide, Atsushi

2014-08-01

The present study aimed to clarify the incidence and outcomes of sudden cardiac arrests in schools and the clinically relevant characteristics of individuals who experienced sudden cardiac arrests. We obtained data on sudden cardiac arrests that occurred in schools between January 1, 2005 and December 31, 2009 from the database of the Utstein Osaka Project, a population-based observational study on out-of-hospital cardiac arrests in Osaka, Japan. The data were analyzed to show the epidemiological features of sudden cardiac arrests in schools in conjunction with prehospital documentation. In total, 44 cases were registered as sudden cardiac arrests in schools during the study period. Of these, 34 cases had nontraumatic cardiac arrests. Twenty-one cases (62%) had pre-existing cardiac diseases and/or collapsed during physical exercise. Twenty-three cases (68%) presented with ventricular fibrillation or pulseless ventricular tachycardia, with cases of survival 1 month after cardiac arrest and those having favourable neurological outcome (Cerebral Performance Category 1 or 2) being 12 (52%) and 10 (43%), respectively. The incidence of sudden cardiac arrests in students was 0.23 per 100,000 persons per year, ranging from 0.08 in junior high school to 0.64 in high school. The incidence of sudden cardiac arrests in school faculty and staff was 0.51 per 100,000 persons per year, a rate approximately 2 times of that observed in the students. Although sudden cardiac arrests in schools is rare, they majorly occurred in individuals with cardiac diseases and/or during physical exercise and presented as ventricular fibrillation or pulseless ventricular tachycardia observed initially as cardiac arrhythmia. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

C.A.U.S.E.: Cardiac arrest ultra-sound exam--a better approach to managing patients in primary non-arrhythmogenic cardiac arrest.

PubMed

Hernandez, Caleb; Shuler, Klaus; Hannan, Hashibul; Sonyika, Chionesu; Likourezos, Antonios; Marshall, John

2008-02-01

Cardiac arrest is a condition frequently encountered by physicians in the hospital setting including the Emergency Department, Intensive Care Unit and medical/surgical wards. This paper reviews the current literature involving the use of ultrasound in resuscitation and proposes an algorithmic approach for the use of ultrasound during cardiac arrest. At present there is the need for a means of differentiating between various causes of cardiac arrest, which are not a direct result of a primary ventricular arrhythmia. Identifying the cause of pulseless electrical activity or asystole is important as the underlying cause is what guides management in such cases. This approach, incorporating ultrasound to manage cardiac arrest aids in the diagnosis of the most common and easily reversible causes of cardiac arrest not caused by primary ventricular arrhythmia, namely; severe hypovolemia, tension pneumothorax, cardiac tamponade, and massive pulmonary embolus. These four conditions are addressed in this paper using four accepted emergency ultrasound applications to be performed during resuscitation of a cardiac arrest patient with the aim of determining the underlying cause of a cardiac arrest. Identifying the underlying cause of cardiac arrest represents the one of the greatest challenges of managing patients with asystole or PEA and accurate determination has the potential to improve management by guiding therapeutic decisions. We include several clinical images demonstrating examples of cardiac tamponade, massive pulmonary embolus, and severe hypovolemia secondary to abdominal aortic aneurysm. In conclusion, this protocol has the potential to reduce the time required to determine the etiology of a cardiac arrest and thus decrease the time between arrest and appropriate therapy.

Prescription Monitoring Program Trends Among Individuals Arrested in Maine for Trafficking Prescription Drugs in 2014.

PubMed

McCall, Kenneth; Nichols, Stephanie D; Holt, Christina; Ochs, Leslie; Cattabriga, Gary; Tu, Chunhao

2016-06-01

To evaluate controlled substance prescribing trends available in the Maine Prescription Monitoring Program (PMP) among individuals arrested for prescription drug "trafficking." The demographic characteristics of the individuals who had matching prescription records in the PMP within 90 days of the arrest were identified. A population-based, retrospective cohort study using data from the Maine Diversion Alert Program (DAP) and the Maine PMP. The study population consisted of persons arrested for trafficking prescription drugs in Maine during the 2014 calendar year from January 1 to December 31. There were 594 trafficking arrests reported by the Maine DAP in 2014. The study population consisted of the 235 persons (40%) with arrests involving controlled prescription medications. The mean age of these persons was 33 years (range 18-77 yrs), and 156 (66%) were male. Arrests involved 154 prescription opioids (65%), seven stimulants (3%), seven benzodiazepines (3%), and 77 unspecified controlled prescription drugs (33%). A minority of individuals (n=57, 24%) had a prescription record in the PMP that matched the substance involved in the arrest. Only one person with matching PMP and arrest records utilized ≥ 5 prescribers, while none used ≥ 5 pharmacies within 90 days before the arrest. Payment methods for matching prescriptions were commercial insurance (n=28, 49%), Medicaid (n=19, 33%), Medicare (n=5, 9%), and cash (n=5, 9%). The majority (76%) of persons arrested for prescription drug trafficking did not have PMP records and did not directly obtain the diverted medication from a licensed pharmacy. Traditional red flags, like cash payment and using multiple prescribers or pharmacies, were uncommon. Therefore, arrest records for diversion and PMPs are distinct and complementary tools for identifying individuals at risk for substance misuse. © 2016 Pharmacotherapy Publications, Inc.

Automated external defibrillators inaccessible to more than half of nearby cardiac arrests in public locations during evening, nighttime, and weekends.

PubMed

Hansen, Carolina Malta; Wissenberg, Mads; Weeke, Peter; Ruwald, Martin Huth; Lamberts, Morten; Lippert, Freddy Knudsen; Gislason, Gunnar Hilmar; Nielsen, Søren Loumann; Køber, Lars; Torp-Pedersen, Christian; Folke, Fredrik

2013-11-12

Despite wide dissemination, use of automated external defibrillators (AEDs) in community settings is limited. We assessed how AED accessibility affected coverage of cardiac arrests in public locations. We identified cardiac arrests in public locations (1994-2011) in terms of location and time and viewed them in relation to the location and accessibility of all AEDs linked to the emergency dispatch center as of December 31, 2011, in Copenhagen, Denmark. AED coverage of cardiac arrests was defined as cardiac arrests within 100 m (109.4 yd) of an AED and further categorized according to AED accessibility at the time of cardiac arrest. Daytime, evening, and nighttime were defined as 8 am to 3:59 pm, 4 to 11:59 pm, and midnight to 7:59 am, respectively. Of 1864 cardiac arrests in public locations, 61.8% (n=1152) occurred during the evening, nighttime, or weekends. Of 552 registered AEDs, 9.1% (n=50) were accessible at all hours, and 96.4% (n=532) were accessible during the daytime on all weekdays. Regardless of AED accessibility, 28.8% (537 of 1864) of all cardiac arrests were covered by an AED. Limited AED accessibility decreased coverage of cardiac arrests by 4.1% (9 of 217) during the daytime on weekdays and by 53.4% (171 of 320) during the evening, nighttime, and weekends. Limited AED accessibility at the time of cardiac arrest decreased AED coverage by 53.4% during the evening, nighttime, and weekends, which is when 61.8% of all cardiac arrests in public locations occurred. Thus, not only strategic placement but also uninterrupted AED accessibility warrant attention if public-access defibrillation is to improve survival after out-of-hospital cardiac arrest.

Right ventricular dysfunction after resuscitation predicts poor outcomes in cardiac arrest patients independent of left ventricular function.

PubMed

Ramjee, Vimal; Grossestreuer, Anne V; Yao, Yuan; Perman, Sarah M; Leary, Marion; Kirkpatrick, James N; Forfia, Paul R; Kolansky, Daniel M; Abella, Benjamin S; Gaieski, David F

2015-11-01

Determination of clinical outcomes following resuscitation from cardiac arrest remains elusive in the immediate post-arrest period. Echocardiographic assessment shortly after resuscitation has largely focused on left ventricular (LV) function. We aimed to determine whether post-arrest right ventricular (RV) dysfunction predicts worse survival and poor neurologic outcome in cardiac arrest patients, independent of LV dysfunction. A single-center, retrospective cohort study at a tertiary care university hospital participating in the Penn Alliance for Therapeutic Hypothermia (PATH) Registry between 2000 and 2012. 291 in- and out-of-hospital adult cardiac arrest patients at the University of Pennsylvania who had return of spontaneous circulation (ROSC) and post-arrest echocardiograms. Of the 291 patients, 57% were male, with a mean age of 59 ± 16 years. 179 (63%) patients had LV dysfunction, 173 (59%) had RV dysfunction, and 124 (44%) had biventricular dysfunction on the initial post-arrest echocardiogram. Independent of LV function, RV dysfunction was predictive of worse survival (mild or moderate: OR 0.51, CI 0.26-0.99, p<0.05; severe: OR 0.19, CI 0.06-0.65, p=0.008) and neurologic outcome (mild or moderate: OR 0.33, CI 0.17-0.65, p=0.001; severe: OR 0.11, CI 0.02-0.50, p=0.005) compared to patients with normal RV function after cardiac arrest. Echocardiographic findings of post-arrest RV dysfunction were equally prevalent as LV dysfunction. RV dysfunction was significantly predictive of worse outcomes in post-arrest patients after accounting for LV dysfunction. Post-arrest RV dysfunction may be useful for risk stratification and management in this high-mortality population. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Medical physics in 2020: will we still be relevant?

PubMed

Ng, K H

2008-06-01

From the time when Roentgen and other physicists made the discoveries which led to the development of radiology, radiotherapy and nuclear medicine, medical physicists have played a pivotal role in the development of new technologies that have revolutionized the way medicine is practiced today. Medical physicists have been transforming scientific advances in the research laboratories to improving the quality of life for patients; indeed innovations such as computed tomography, positron emission tomography and linear accelerators which collectively have improved the medical outcomes for millions of people. In order for radiation-delivery techniques to improve in targeting accuracy, optimal dose distribution and clinical outcome, convergence of imaging and therapy is the key. It is timely for these two specialties to work closer again. This can be achieved by means of cross-disciplinary research, common conferences and workshops, and collaboration in education and training for all. The current emphasis is on enhancing the specific skill development and competency of a medical physicist at the expense of their future roles and opportunities. This emphasis is largely driven by financial and political pressures for optimizing limited resources in health care. This has raised serious concern on the ability of the next generation of medical physicists to respond to new technologies. In addition in the background loom changes of tsunami proportion. The clearly defined boundaries between the different disciplines in medicine are increasingly blurred and those between diagnosis, therapy and management are also following suit. The use of radioactive particles to treat tumours using catheters, high-intensity focused ultrasound, electromagnetic wave ablation and photodynamic therapy are just some areas challenging the old paradigm. The uncertainty and turf battles will only explode further and medical physicists will not be spared. How would medical physicists fit into this changing scenario? We are in the midst of molecular revolution. Are we prepared to explore the newer technologies such as nanotechnology, drug discovery, pre-clinical imaging, optical imaging and biomedical informatics? How are our curricula adapting to the changing needs? We should remember the late Professor John Cameron who advocated imagination and creativity - these important attributes will make us still relevant in 2020 and beyond. To me the future is clear: "To achieve more, we should imagine together."

Post-arrest therapeutic hypothermia in pediatric patients with congenital heart disease.

PubMed

Cheng, Henry H; Rajagopal, Satish K; Sansevere, Arnold J; McDavitt, Erica; Wigmore, Daniel; Mecklosky, Jessica; Andren, Kristofer; Williams, Kathryn A; Danehy, Amy; Soul, Janet S

2018-05-01

While therapeutic hypothermia (TH) is an effective neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy, TH has not been demonstrated to improve outcome in other pediatric populations. Patients with acquired or congenital heart disease (CHD) are at high risk of both cardiac arrest and neurodevelopmental impairments, and therapies are needed to improve neurologic outcome. The primary goal of our study was to compare safety/efficacy outcomes in post-arrest CHD patients treated with TH versus controls not treated with TH. Patients with CHD treated during the first 18 months after initiation of a post-arrest TH protocol (temperature goal: 33.5 °C) were compared to historical and contemporary post-arrest controls not treated with TH. Post-arrest data, including temperature, safety measures (e.g. arrhythmia, bleeding), neurodiagnostic data (EEG, neuroimaging), and survival were compared. Thirty arrest episodes treated with TH and 51 control arrest episodes were included. The groups did not differ in age, duration of arrest, post-arrest lactate, or use of ECMO-CPR. The TH group's post-arrest temperature was significantly lower than control's (33.6 ± 0.2 °C vs 34.7 ± 0.5 °C, p < 0.001). There was no difference between the groups in safety/efficacy measures, including arrhythmia, infections, chest-tube output, or neuroimaging abnormalities, nor in hospital survival (TH 61.5% vs control 59.1%, p = NS). Significantly more controls had seizures than TH patients (26.1% vs. 4.0%, p = 0.04). Almost all seizures were subclinical and occurred more than 24 h post-arrest. Our data show that pediatric CHD patients who suffer cardiac arrest can be treated effectively and safely with TH, which may decrease the incidence of seizures. Copyright © 2018 Elsevier B.V. All rights reserved.

Risk factors and outcomes of in-hospital cardiac arrest following pediatric heart operations of varying complexity.

PubMed

Gupta, Punkaj; Rettiganti, Mallikarjuna; Jeffries, Howard E; Scanlon, Matthew C; Ghanayem, Nancy S; Daufeldt, Jennifer; Rice, Tom B; Wetzel, Randall C

2016-08-01

Multi center data regarding cardiac arrest in children undergoing heart operations of varying complexity are limited. Children <18 years undergoing heart surgery (with or without cardiopulmonary bypass) in the Virtual Pediatric Systems (VPS, LLC) Database (2009-2014) were included. Multivariable mixed logistic regression models were adjusted for patient's characteristics, surgical risk category (STS-EACTS Categories 1, 2, and 3 classified as "low" complexity and Categories 4 and 5 classified as "high" complexity), and hospital characteristics. Overall, 26,909 patients (62 centers) were included. Of these, 2.7% had cardiac arrest after cardiac surgery with an associated mortality of 31%. The prevalence of cardiac arrest was lower among patients undergoing low complexity operations (low complexity vs. high complexity: 1.7% vs. 5.9%). Unadjusted outcomes after cardiac arrest were significantly better among patients undergoing low complexity operations (mortality: 21.6% vs. 39.1%, good neurological outcomes: 78.7% vs. 71.6%). In adjusted models, odds of cardiac arrest were significantly lower among patients undergoing low complexity operations (OR: 0.55, 95% CI: 0.46-0.66). Adjusted models, however, showed no difference in mortality or neurological outcomes after cardiac arrest regardless of surgical complexity. Further, our results suggest that incidence of cardiac arrest and mortality after cardiac arrest are a function of patient characteristics, surgical risk category, and hospital characteristics. Presence of around the clock in-house attending level pediatric intensivist coverage was associated with lower incidence of post-operative cardiac arrest, and presence of a dedicated cardiac ICU was associated with lower mortality after cardiac arrest. This study suggests that the patients undergoing high complexity operations are a higher risk group with increased prevalence of post-operative cardiac arrest. These data further suggest that patients undergoing high complexity operations can be rescued after cardiac arrest with a high survival rate. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Crack propagation and arrest in CFRP materials with strain softening regions

NASA Astrophysics Data System (ADS)

Dilligan, Matthew Anthony

Understanding the growth and arrest of cracks in composite materials is critical for their effective utilization in fatigue-sensitive and damage susceptible applications such as primary aircraft structures. Local tailoring of the laminate stack to provide crack arrest capacity intermediate to major structural components has been investigated and demonstrated since some of the earliest efforts in composite aerostructural design, but to date no rigorous model of the crack arrest mechanism has been developed to allow effective sizing of these features. To address this shortcoming, the previous work in the field is reviewed, with particular attention to the analysis methodologies proposed for similar arrest features. The damage and arrest processes active in such features are investigated, and various models of these processes are discussed and evaluated. Governing equations are derived based on a proposed mechanistic model of the crack arrest process. The derived governing equations are implemented in a numerical model, and a series of simulations are performed to ascertain the general characteristics of the proposed model and allow qualitative comparison to existing experimental results. The sensitivity of the model and the arrest process to various parameters is investigated, and preliminary conclusions regarding the optimal feature configuration are developed. To address deficiencies in the available material and experimental data, a series of coupon tests are developed and conducted covering a range of arrest zone configurations. Test results are discussed and analyzed, with a particular focus on identification of the proposed failure and arrest mechanisms. Utilizing the experimentally derived material properties, the tests are reproduced with both the developed numerical tool as well as a FEA-based implementation of the arrest model. Correlation between the simulated and experimental results is analyzed, and future avenues of investigation are identified. Utilizing the developed model, a sensitivity study is conducted to assess the current proposed arrest configuration. Optimum distribution and sizing of the arrest zones is investigated, and general design guidelines are developed.

Location of cardiac arrest and impact of pre-arrest chronic disease and medication use on survival.

PubMed

Granfeldt, Asger; Wissenberg, Mads; Hansen, Steen Møller; Lippert, Freddy K; Torp-Pedersen, Christian; Christensen, Erika Frischknecht; Christiansen, Christian Fynbo

2017-05-01

Cardiac arrest in a private location is associated with a higher mortality when compared to public location. Past studies have not accounted for pre-arrest factors such as chronic disease and medication. To investigate whether the association between cardiac arrest in a private location and a higher mortality can be explained by differences in chronic diseases and medication. We identified 27,771 out-of-hospital cardiac arrest patients ≥18 years old from the Danish Cardiac Arrest Registry (2001-2012). Using National Registries, we identified pre-arrest chronic disease and medication. To investigate the importance of cardiac arrest related factors and chronic disease and medication use we performed adjusted Cox regression analyses during day 0-7 and day 8-365 following cardiac arrest to calculate hazard ratios (HR) for death. Day 0-7: Un-adjusted HR for death day 0-7 was 1.21 (95%CI:1.18-1.25) in private compared to public location. When including cardiac arrest related factors HR for death was 1.09 (95%CI:1.06-1.12). Adding chronic disease and medication to the analysis changed HR for death to 1.08 (95%CI:1.05-1.12). 8-365 day: The un-adjusted HR for death day 8-365 was 1.70 (95% CI: 1.43-2.02) in private compared to public location. When including cardiac arrest related factors the HR decreased to 1.39 (95% CI: 1.14-1.68). Adding chronic disease and medication to the analysis changed HR for death to 1.27 (95% CI:1.04-1.54). The higher mortality following cardiac arrest in a private location is partly explained by a higher prevalence of chronic disease and medication use in patients surviving until day 8. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluation of the Housing First program in patients with severe mental disorders in France: study protocol for a randomized controlled trial

PubMed Central

2013-01-01

Background Recent studies in North American contexts have suggested that the Housing First model is a promising strategy for providing effective services to homeless people with mental illness. In the context of the highly generous French national health and social care system, which is easily accessible and does not require out-of-pocket payment, the French Health Ministry insists on rigorous techniques, including randomized protocols, to evaluate the impact of Housing First approaches in France. Method and design A prospective randomized trial was designed to assess the impact of a Housing First intervention on health outcomes and costs over a period of 24 months on homeless people with severe mental illness, compared to Treatment-As-Usual. The study is being conducted in four cities in France: Lille, Marseille, Paris and Toulouse. The inclusion criteria are as follows: over 18 years of age, absolutely homeless or in precarious housing, and possessing a ‘high’ level of need: diagnosis of schizophrenia or bipolar disorder and moderate to severe disability according to the Multnomah Community Ability Scale (score ≤ 62) and at least one of the following three criteria: 1) having been hospitalized for mental illness two or more times in any one year during the preceding five years; 2) co-morbid alcohol or substance use; and 3) having been recently arrested or incarcerated. Participants will be randomized to receiving the Housing First intervention or Treatment-As-Usual. The Housing First intervention provides immediate access to independent housing and community care. The primary outcome criterion is the use of high-cost health services (that is,, number of hospital admissions and number of emergency department visits) during the 24-month follow-up period. Secondary outcome measures include health outcomes, social functioning, housing stability and contact with police services. An evaluation of the cost-effectiveness and cost-utility of Housing First will also be conducted. A total of 300 individuals per group will be included. Discussion This is the first study to examine the impact of a Housing First intervention compared to Treatment-As-Usual in France. It should provide key information to policymakers concerning the cost-effectiveness and health outcomes of the Housing First model in the French context. Trial registration The current clinical trial number is NCT01570712 PMID:24063556

Association between a Hospital’s Rate of Cardiac Arrest Incidence and Cardiac Arrest Survival

PubMed Central

Chen, Lena M.; Nallamothu, Brahmajee K.; Spertus, John A.; Li, Yan; Chan, Paul S.

2014-01-01

Context National efforts to measure hospital performance for cardiac arrest have focused on case survival, with the hope of improving survival after cardiac arrest. However, it is plausible that hospitals with high case-survival rates do a poor job of preventing cardiac arrests in the first place. Objective To describe the association between inpatient cardiac arrest incidence and survival rates. Design, Setting, and Patients Within a large, national registry, we identified hospitals with at least 50 adult in-hospital cardiac arrest cases between January 1, 2000 and November 30, 2009. We used multivariable hierarchical regression to evaluate the correlation between a hospital’s cardiac arrest incidence rate and its case-survival rate after adjusting for patient and hospital characteristics. Main Outcome Measure The correlation between a hospital’s incidence rate and case-survival rate for cardiac arrest. Results Of 102,153 cases at 358 hospitals, the median hospital cardiac arrest incidence rate was 4.02 per 1000 admissions (IQR: 2.95 to 5.65 per 1000 admissions), and the median hospital case-survival rate was 18.8% (IQR: 14.5% to 22.6%). In crude analyses, hospitals with higher case-survival rates also had lower cardiac arrest incidence (correlation of -0.16; P=0.003). This relationship persisted after adjusting for patient characteristics (correlation of -0.15; P=0.004). After adjusting for potential mediators of this relationship (i.e., hospital characteristics), the relationship between incidence and case-survival was attenuated (correlation of -0.07; P=0.18). The one modifiable hospital factor that most attenuated this relationship was a hospital’s nurse-to-bed ratio (correlation of -0.12; P=0.03). Conclusions Hospitals with exceptional rates of survival for in-hospital cardiac arrest are also better at preventing cardiac arrests, even after adjusting for patient case-mix. This relationship is partially mediated by measured hospital attributes. Performance measures focused on case-survival rates appear to be an appropriate first step in quality measurement for in-hospital cardiac arrest. PMID:23689900

Sudden Cardiac Arrest during Participation in Competitive Sports.

PubMed

Landry, Cameron H; Allan, Katherine S; Connelly, Kim A; Cunningham, Kris; Morrison, Laurie J; Dorian, Paul

2017-11-16

The incidence of sudden cardiac arrest during participation in sports activities remains unknown. Preparticipation screening programs aimed at preventing sudden cardiac arrest during sports activities are thought to be able to identify at-risk athletes; however, the efficacy of these programs remains controversial. We sought to identify all sudden cardiac arrests that occurred during participation in sports activities within a specific region of Canada and to determine their causes. In this retrospective study, we used the Rescu Epistry cardiac arrest database (which contains records of every cardiac arrest attended by paramedics in the network region) to identify all out-of-hospital cardiac arrests that occurred from 2009 through 2014 in persons 12 to 45 years of age during participation in a sport. Cases were adjudicated as sudden cardiac arrest (i.e., having a cardiac cause) or as an event resulting from a noncardiac cause, on the basis of records from multiple sources, including ambulance call reports, autopsy reports, in-hospital data, and records of direct interviews with patients or family members. Over the course of 18.5 million person-years of observation, 74 sudden cardiac arrests occurred during participation in a sport; of these, 16 occurred during competitive sports and 58 occurred during noncompetitive sports. The incidence of sudden cardiac arrest during competitive sports was 0.76 cases per 100,000 athlete-years, with 43.8% of the athletes surviving until they were discharged from the hospital. Among the competitive athletes, two deaths were attributed to hypertrophic cardiomyopathy and none to arrhythmogenic right ventricular cardiomyopathy. Three cases of sudden cardiac arrest that occurred during participation in competitive sports were determined to have been potentially identifiable if the athletes had undergone preparticipation screening. In our study involving persons who had out-of-hospital cardiac arrest, the incidence of sudden cardiac arrest during participation in competitive sports was 0.76 cases per 100,000 athlete-years. The occurrence of sudden cardiac arrest due to structural heart disease was uncommon during participation in competitive sports. (Funded by the National Heart, Lung, and Blood Institute and others.).

30 CFR 77.508-1 - Lightning arresters; wires entering buildings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Lightning arresters; wires entering buildings... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.508-1 Lightning arresters; wires entering buildings. Lightning arresters protecting exposed telephone wires entering buildings shall be provided at...

30 CFR 77.508-1 - Lightning arresters; wires entering buildings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Lightning arresters; wires entering buildings... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.508-1 Lightning arresters; wires entering buildings. Lightning arresters protecting exposed telephone wires entering buildings shall be provided at...

30 CFR 77.508-1 - Lightning arresters; wires entering buildings.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Lightning arresters; wires entering buildings... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.508-1 Lightning arresters; wires entering buildings. Lightning arresters protecting exposed telephone wires entering buildings shall be provided at...

30 CFR 77.508-1 - Lightning arresters; wires entering buildings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Lightning arresters; wires entering buildings... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.508-1 Lightning arresters; wires entering buildings. Lightning arresters protecting exposed telephone wires entering buildings shall be provided at...

30 CFR 77.508-1 - Lightning arresters; wires entering buildings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Lightning arresters; wires entering buildings... OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.508-1 Lightning arresters; wires entering buildings. Lightning arresters protecting exposed telephone wires entering buildings shall be provided at...

Development of a simple algorithm to guide the effective management of traumatic cardiac arrest.

PubMed

Lockey, David J; Lyon, Richard M; Davies, Gareth E

2013-06-01

Major trauma is the leading worldwide cause of death in young adults. The mortality from traumatic cardiac arrest remains high but survival with good neurological outcome from cardiopulmonary arrest following major trauma has been regularly reported. Rapid, effective intervention is required to address potential reversible causes of traumatic cardiac arrest if the victim is to survive. Current ILCOR guidelines do not contain a standard algorithm for management of traumatic cardiac arrest. We present a simple algorithm to manage the major trauma patient in actual or imminent cardiac arrest. We reviewed the published English language literature on traumatic cardiac arrest and major trauma management. A treatment algorithm was developed based on this and the experience of treatment of more than a thousand traumatic cardiac arrests by a physician - paramedic pre-hospital trauma service. The algorithm addresses the need treat potential reversible causes of traumatic cardiac arrest. This includes immediate resuscitative thoracotomy in cases of penetrating chest trauma, airway management, optimising oxygenation, correction of hypovolaemia and chest decompression to exclude tension pneumothorax. The requirement to rapidly address a number of potentially reversible pathologies in a short time period lends the management of traumatic cardiac arrest to a simple treatment algorithm. A standardised approach may prevent delay in diagnosis and treatment and improve current poor survival rates. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Enforcement following 0.08% BAC law change: Sex-specific consequences of changing arrest practices?

PubMed Central

Schwartz, Jennifer; Davaran, Ardavan

2013-01-01

This research evaluated effects of stricter 0.08% BAC drunken driving law on changes in sex-specific DUI arrest rates, controlling for increased law enforcement resources and shifts in DUI-related behaviors. Another main purpose, the study assessed female/male differences in arrest increases due to broader enforcement standards and efforts. Panel data was assembled for 24 states over 1990–2007 on DUI arrests, alcohol policy, law enforcement resources, drinking and drunken driving prevalence. Two-way fixed-effects seemingly unrelated regression models predicted female versus male changes in DUI arrests following implementation of lower legal limits of intoxication, net controls. Findings suggest, first, a broader legal definition of drunken driving intending to officially sanction less serious offenders (0.08% vs. 0.10% BAC) was associated with increased DUI arrests for both sexes. Second, growth in specialized DUI-enforcement units also was related to increased arrests. Whereas male and female arrest trends were equally affected by the direct net-widening effects of 0.08% BAC alcohol-policy, specialized DUI-enforcement efforts to dig deeper into the offender-pool had stronger arrest-producing effects on females, particularly prior to law change. Specifying how changes in law and enforcement resources affect arrest outcomes is an important precursor to alcohol-policy analyses of effectiveness. A potential unintended consequence, effects of law and enforcement may differ across population segments. PMID:23773958

Does Quality-of-Life Policing Widen the Net? A Partial Analysis

PubMed Central

Golub, Andrew; Johnson, Bruce D.; Taylor, Angela; Eterno, John

2013-01-01

In the 1990s, the New York City Police Department instituted a policy of arresting individuals for less serious offenses that impinge on the city’s quality of life (QOL). Critics contend that QOL policing widened the net for arrest, especially among minorities. Alternatively, QOL policing could have created additional opportunities for arresting individuals from the same populations that tend to incur arrests for more serious offenses. This article reports on a comparison of New York City QOL and serious arrestees interviewed in 1999 that provides partial support for this alternative hypothesis; the two groups were similar regarding prior arrests, participation in QOL offenses, and demographic composition. Of note, blacks and Hispanics comprised close to 90% of both arrest populations. These findings suggest that QOL policing does not necessarily widen the net for arrest. PMID:25309134

A proposal to study the experience of female scientists in Mexico: Physicists as a case study

NASA Astrophysics Data System (ADS)

Martínez, Amalia; Blázquez, Norma; Gómez, Yolanda; Vales, Caridad; Meza-Montes, Lilia

2013-03-01

Although the design of public policies to support and improve the status and opportunities for female scientists requires reliable data, studies of this type have not been done in Mexico. We present a proposal to conduct such a study at the national level, with physicists as a test group.

SPIRES (STANFORD PHYSICS INFORMATION RETRIEVAL SYSTEM). ANNUAL REPORT.

ERIC Educational Resources Information Center

PARKER, EDWIN B.

SPIRES WAS PLANNED AS A FIVE-YEAR EFFORT TO DEVELOP AND STUDY AN EXPERIMENTAL SYSTEM FOR PROVIDING FOR THE SCIENTIFIC INFORMATION NEEDS OF PHYSICISTS AT STANFORD. THERE ARE TWO COMPONENTS TO THE SPIRES PROJECT. ONE IS TO STUDY THE INFORMATION NEEDS AND INFORMATION-SEEKING BEHAVIOR OF A USER POPULATION OF ABOUT 100 HIGH- ENERGY PHYSICISTS. DETAILS…

Women and Men of the Manhattan Project

ERIC Educational Resources Information Center

Marshall, Jill; Herzenber, Caroline; Howes, Ruth; Weaver, Ellen; Gans, Dorothy

2010-01-01

In the early 1990s Ruth Howes, a nuclear physicist on the faculty at Ball State University, and Caroline Herzenberg, a nuclear physicist at Argonne National Laboratory, were asked to write a chapter on the Manhattan Project for a volume on women working on weapons development for the military. Realizing that they knew very little about the women…

Women Physicists Speak Again. AIP Report, Number R-441

ERIC Educational Resources Information Center

Ivie, Rachel; Guo, Stacy

2006-01-01

Across the world, women in physics have much in common. In almost all countries, women are largely under represented in physics. In the majority of countries for which data was obtainable for this report from reliable statistical agencies, women earned no more than one-fifth of the PhDs in physics. Many women physicists across the world also…

Why Aren’t Lightsabers Real Yet? Get the Lowdown from a Laser Physicist

ScienceCinema

Hunsberger, Maren; Liao, Zhi

2018-06-22

The release of "Star Wars: The Force Awakens" begs the obvious question: Why aren't lightsabers real yet? LLNL science communicator Maren Hunsberger gets the lowdown from laser physicist Zhi Liao in this first installment of "Inside the Lab," a new YouTube series exploring crazy-cool science questions.

Educational Pathways of Black Women Physicists: Stories of Experiencing and Overcoming Obstacles in Life

ERIC Educational Resources Information Center

Rosa, Katemari; Mensah, Felicia Moore

2016-01-01

This is an empirical study on the underrepresentation of people of color in scientific careers. Grounded in critical race theory, the paper examines the lived experiences of six Black women physicists and addresses obstacles faced in their career paths and strategies used to overcome these obstacles. Data for this study were collected through…

Learning from Mistakes: The Effect of Students' Written Self-Diagnoses on Subsequent Problem Solving

ERIC Educational Resources Information Center

Mason, Andrew; Yerushalmi, Edit; Cohen, Elisheva; Singh, Chandralekha

2016-01-01

Helping students learn to think like a physicist is an important goal of many introductory physics courses. One characteristic distinguishing more experienced physicists from novice students is that they make better use of problem solving as a learning opportunity. Experts were found to spend more time than novices in monitoring their work,…

Critique and Fiction: Doing Science Right in Rural Education Research

ERIC Educational Resources Information Center

Howley, Craig B.

2006-01-01

This essay explains the relevance of critique in rural education to novels about rural places. The most important quoted passage in the essay is from the noted physicist Richard Feynman: "Science is the belief in the ignorance of experts." Novelist-physicist C. P. Snow, historian Henry Adams, and poet and student-of-mathematics Kelly Cherry also…

Higgs Boson: god particle or divine comedy?

NASA Astrophysics Data System (ADS)

Rangacharyulu, Chary

2013-10-01

While particle physicists around the world rejoice the announcement of discovery of Higgs particle as a momentous event, it is also an opportune moment to assess the physicists' conception of nature. Particle theorists, in their ingenious efforts to unravel mysteries of the physical universe at a very fundamental level, resort to macroscopic many body theoretical methods of solid state physicists. Their efforts render the universe a superconductor of correlated quasi-particle pairs. Experimentalists, devoted to ascertain the elementary constituents and symmetries, depend heavily on numerical simulations based on those models and conform to theoretical slang in planning and interpretation of measurements . It is to the extent that the boundaries between theory/modeling and experiment are blurred. Is it possible that they are meandering in Dante's Inferno?

Half Century of Black-Hole Theory: From Physicists' Purgatory to Mathematicians' Paradise

NASA Astrophysics Data System (ADS)

Carter, Brandon

2006-06-01

Although implicit in the discovery of the Schwarzschild solution 40 years earlier, the issues raised by the theory of what are now known as black holes were so unsettling to physicists of Einstein's generation that the subject remained in a state of semiclandestine gestation until his demise. That turning point — just half a century after Einstein's original foundation of relativity theory, and just half a century ago today — can be considered to mark the birth of black hole theory as a subject of systematic development by physicists of a new and less inhibited generation, whose enthusastic investigations have revealed structures of unforeseen mathematical beauty, even though questions about the physical significance of the concomitant singularities remain controversial.

Device physics vis-à-vis fundamental physics in Cold War America: the case of quantum optics.

PubMed

Bromberg, Joan Lisa

2006-06-01

Historians have convincingly shown the close ties U.S. physicists had with the military during the Cold War and have raised the question of whether this alliance affected the content of physics. Some have asserted that it distorted physics, shifting attention from fundamental problems to devices. Yet the papers of physicists in quantum electronics and quantum optics, fields that have been exemplary for those who hold the distortion thesis, show that the same scientists who worked on military devices simultaneously pursued fundamental and foundational topics. This essay examines one such physicist, Marlan O. Scully, with attention to both his extensive foundational studies and the way in which his applied and basic researches played off each other.

Rationale, development and implementation of the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest.

PubMed

Morrison, Laurie J; Nichol, Graham; Rea, Thomas D; Christenson, Jim; Callaway, Clifton W; Stephens, Shannon; Pirrallo, Ronald G; Atkins, Dianne L; Davis, Daniel P; Idris, Ahamed H; Newgard, Craig

2008-08-01

To describe the development, design and consequent scientific implications of the Resuscitation Outcomes Consortium (ROC) population-based registry; ROC Epistry-Cardiac Arrest. The ROC Epistry--Cardiac Arrest is designed as a prospective population-based registry of all Emergency Medical Services (EMSs)-attended 9-1-1 calls for patients with out-of-hospital cardiac arrest occurring in the geographical area described by the eight US and three Canadian regions. The dataset was derived by an North American interdisciplinary steering committee. Enrolled cases include individuals of all ages who experience cardiac arrest outside the hospital, with evaluation by organized EMS personnel and: (a) attempts at external defibrillation (by lay responders or emergency personnel), or chest compressions by organized EMS personnel; (b) were pulseless but did not receive attempts to defibrillate or CPR by EMS personnel. Selected data items are categorized as mandatory or optional and undergo revisions approximately every 12 months. Where possible all definitions are referenced to existing literature. Where a common definition did not exist one was developed. Optional items include standardized CPR process data elements. It is anticipated the ROC Epistry--Cardiac Arrest will enroll between approximately 9000 and 13,500 treated all rhythm arrests and 4000 and 5000 ventricular fibrillation arrests annually and approximately 8000 EMS-attended but untreated arrests. We describe the rationale, development, design and future implications of the ROC Epistry--Cardiac Arrest. This paper will serve as the reference for subsequent ROC manuscripts and for the common data elements captured in both ROC Epistry--Cardiac Arrest and the ROC trials.

Differential arrest and adhesion of tumor cells and microbeads in the microvasculature

PubMed Central

Guo, Peng; Cai, Bin; Lei, Ming; Liu, Yang

2013-01-01

To investigate the mechanical mechanisms behind tumor cell arrest in the microvasculature, we injected fluorescently labeled human breast carcinoma cells or similarly sized rigid beads into the systemic circulation of a rat. Their arrest patterns in the microvasculature of mesentery were recorded and quantified. We found that 93% of rigid beads were arrested either at arteriole–capillary intersections or in capillaries. Only 3% were at the capillary–postcapillary venule intersections and in postcapillary venules. In contrast, most of the flexible tumor cells were either entrapped in capillaries or arrested at capillary or postcapillary venule–postcapillary venule intersections and in postcapillary venules. Only 12% of tumor cells were arrested at the arteriole–capillary intersections. The differential arrest and adhesion of tumor cells and microbeads in the microvasculature was confirmed by a χ2 test (p < 0.001). These results demonstrate that mechanical trapping was responsible for almost all the arrest of beads and half the arrest of tumor cells. Based on the measured geometry and blood flow velocities at the intersections, we also performed a numerical simulation using commercial software (ANSYS CFX 12.01) to depict the detailed distribution profiles of the velocity, shear rate, and vorticity at the intersections where tumor cells preferred to arrest and adhere. Simulation results reveal the presence of localized vorticity and shear rate regions at the turning points of the microvessel intersections, implying that hemodynamic factors play an important role in tumor cell arrest in the microcirculation. Our study helps elucidate long-debated issues related to the dominant factors in early-stage tumor hematogenous metastasis. PMID:23880911

Differential arrest and adhesion of tumor cells and microbeads in the microvasculature.

PubMed

Guo, Peng; Cai, Bin; Lei, Ming; Liu, Yang; Fu, Bingmei M

2014-06-01

To investigate the mechanical mechanisms behind tumor cell arrest in the microvasculature, we injected fluorescently labeled human breast carcinoma cells or similarly sized rigid beads into the systemic circulation of a rat. Their arrest patterns in the microvasculature of mesentery were recorded and quantified. We found that 93% of rigid beads were arrested either at arteriole-capillary intersections or in capillaries. Only 3% were at the capillary-postcapillary venule intersections and in postcapillary venules. In contrast, most of the flexible tumor cells were either entrapped in capillaries or arrested at capillary or postcapillary venule-postcapillary venule intersections and in postcapillary venules. Only 12% of tumor cells were arrested at the arteriole-capillary intersections. The differential arrest and adhesion of tumor cells and microbeads in the microvasculature was confirmed by a χ(2) test (p < 0.001). These results demonstrate that mechanical trapping was responsible for almost all the arrest of beads and half the arrest of tumor cells. Based on the measured geometry and blood flow velocities at the intersections, we also performed a numerical simulation using commercial software (ANSYS CFX 12.01) to depict the detailed distribution profiles of the velocity, shear rate, and vorticity at the intersections where tumor cells preferred to arrest and adhere. Simulation results reveal the presence of localized vorticity and shear rate regions at the turning points of the microvessel intersections, implying that hemodynamic factors play an important role in tumor cell arrest in the microcirculation. Our study helps elucidate long-debated issues related to the dominant factors in early-stage tumor hematogenous metastasis.

Legal system involvement and costs for persons in treatment for severe mental illness and substance use disorders.

PubMed

Clark, R E; Ricketts, S K; McHugo, G J

1999-05-01

Persons with co-occurring severe mental illness and substance use disorders were followed for three years to better understand how they are involved with the legal system and to identify factors associated with different kinds of involvement. Data came from a three-year study of 203 persons enrolled in specialized treatment for dual disorders. Cost and utilization data were collected from multiple data sources, including police, sheriffs and deputies, officers of the court, public defenders, prosecutors, private attorneys, local and county jails, state prisons, and paid legal guardians. Over three years 169 participants (83 percent) had contact with the legal system, and 90 (44 percent) were arrested at least once. Participants were four times more likely to have encounters with the legal system that did not result in arrest than they were to be arrested. Costs associated with nonarrest encounters were significantly less than costs associated with arrests. Mean costs per person associated with an arrest were $2,295, and mean costs associated with a nonarrest encounter were $385. Combined three-year costs averaged $2,680 per person. Arrests and incarcerations declined over time. Continued substance use and unstable housing were associated with a greater likelihood of arrest. Poor treatment engagement was associated with multiple arrests. Men were more likely to be arrested, and women were more likely to be the victims of crime. Effective treatment of substance use among persons with mental illness appears to reduce arrests and incarcerations but not the frequency of nonarrest encounters. Stable housing may also reduce the likelihood and number of arrests.

Racial/Ethnic Differences in the Association between Arrest and Unprotected Anal Sex among Young Men Who Have Sex with Men: The P18 Cohort Study.

PubMed

Ompad, Danielle C; Kapadia, Farzana; Bates, Francesca C; Blachman-Forshay, Jaclyn; Halkitis, Perry N

2015-08-01

This analysis aimed to determine whether the relationship between a history of arrest and unprotected anal sex (UAS) is the same for Black/Latino gay, bisexual, and other young men who have sex with men (YMSM) as compared to White/Asian/Pacific Islander (API) YMSM in New York City (NYC). Baseline audio-computer-assisted self-interview (ACASI) and interviewer-administered survey data from a sample of 576 YMSM aged 18-19 years old who self-reported being HIV-negative were analyzed. Data included history of arrest and incarceration as well as UAS in the past 30 days. Race/ethnicity was an effect modifier of the association between arrest and UAS among YMSM: White/API YMSM with a lifetime arrest history were more than three times as likely to report UAS, and Black/Latino YMSM with a lifetime history of arrest were approximately 70 % less likely to report UAS as compared with White/API YMSM with no reported arrest history. Race/ethnicity may modify the relationship between arrest and sexual risk behavior because the etiology of arrest differs by race, as partially evidenced by racial/ethnic disparities in police stop, arrest, and incarceration rates in NYC. Arrest could not only be an indicator of risky behavior for White/API YMSM but also an indicator of discrimination for Black/Latino YMSM. Further research is needed to assess whether the differential associations observed here vis-à-vis race/ethnicity are robust across different populations and different health outcomes.

Post-resuscitation care following out-of-hospital and in-hospital cardiac arrest

PubMed Central

Girotra, Saket; Chan, Paul S; Bradley, Steven M

2016-01-01

Cardiac arrest is a leading cause of death in developed countries. Although a majority of cardiac arrest patients die during the acute event, a substantial proportion of cardiac arrest deaths occur in patients following successful resuscitation and can be attributed to the development of post-cardiac arrest syndrome. There is growing recognition that integrated post-resuscitation care, which encompasses targeted temperature management (TTM), early coronary angiography and comprehensive critical care, can improve patient outcomes. TTM has been shown to improve survival and neurological outcome in patients who remain comatose especially following out-of-hospital cardiac arrest due to ventricular arrhythmias. Early coronary angiography and revascularisation if needed may also be beneficial during the post-resuscitation phase, based on data from observational studies. In addition, resuscitated patients usually require intensive care, which includes mechanical ventilator, haemodynamic support and close monitoring of blood gases, glucose, electrolytes, seizures and other disease-specific intervention. Efforts should be taken to avoid premature withdrawal of life-supporting treatment, especially in patients treated with TTM. Given that resources and personnel needed to provide high-quality post-resuscitation care may not exist at all hospitals, professional societies have recommended regionalisation of post-resuscitation care in specialised ‘cardiac arrest centres’ as a strategy to improve cardiac arrest outcomes. Finally, evidence for post-resuscitation care following in-hospital cardiac arrest is largely extrapolated from studies in patients with out-of-hospital cardiac arrest. Future studies need to examine the effectiveness of different post-resuscitation strategies, such as TTM, in patients with in-hospital cardiac arrest. PMID:26385451

Developmentally arrested structures preceding cerebellar tumors in von Hippel–Lindau disease

PubMed Central

Shively, Sharon B; Falke, Eric A; Li, Jie; Tran, Maxine G B; Thompson, Eli R; Maxwell, Patrick H; Roessler, Erich; Oldfield, Edward H; Lonser, Russell R; Vortmeyer, Alexander O

2011-01-01

There is increasing evidence that suggests that knockout of tumor-suppressor gene function causes developmental arrest and protraction of cellular differentiation. In the peripheral nervous system of patients with the tumor-suppressor gene disorder, von Hippel–Lindau disease, we have demonstrated developmentally arrested structural elements composed of hemangioblast progenitor cells. Some developmentally arrested structural elements progress to a frank tumor, hemangioblastoma. However, in von Hippel–Lindau disease, hemangioblastomas are frequently observed in the cerebellum, suggesting an origin in the central nervous system. We performed a structural and topographic analysis of cerebellar tissues obtained from von Hippel–Lindau disease patients to identify and characterize developmentally arrested structural elements in the central nervous system. We examined the entire cerebella of five tumor-free von Hippel–Lindau disease patients and of three non-von Hippel–Lindau disease controls. In all, 9 cerebellar developmentally arrested structural elements were detected and topographically mapped in 385 blocks of von Hippel–Lindau disease cerebella. No developmentally arrested structural elements were seen in 214 blocks from control cerebella. Developmentally arrested structural elements are composed of poorly differentiated cells that express hypoxia-inducible factor (HIF)2α, but not HIF1α or brachyury, and preferentially involve the molecular layer of the dorsum cerebelli. For the first time, we identify and characterize developmentally arrested structural elements in the central nervous system of von Hippel–Lindau patients. We provide evidence that developmentally arrested structural elements in the cerebellum are composed of developmentally arrested hemangioblast progenitor cells in the molecular layer of the dorsum cerebelli. PMID:21499240

The Spatial-Temporal Pattern of Policing Following a Drug Policy Reform: Triangulating Self-Reported Arrests With Official Crime Statistics

PubMed Central

Gaines, Tommi L.; Werb, Daniel; Arredondo, Jaime; Alaniz, Victor M.; Vilalta, Carlos; Beletsky, Leo

2017-01-01

Background In 2009, Mexico enacted a drug policy reform (Narcomenudeo) designed to divert persons possessing small amounts of illicit drugs to treatment rather than incarceration. To assess reform impact, this study examines the spatial-temporal trends of drug-related policing in Tijuana, Mexico post-enactment. Method Location of self-reported arrests (N=1,160) among a prospective, community-recruited cohort of people who inject drugs (PWID) in Tijuana (N=552) was mapped across city neighborhoods. Official police reports detailing drug-related arrests was triangulated with PWID self-reported arrests. Exploratory spatial data analysis examined the distribution of arrests and spatial association between both datasets across three successive years, 2011–2013. Results In 2011, over half of PWID reported being detained but not officially charged with a criminal offense; in 2013, 90% of arrests led to criminal charges. Official drug-related arrests increased by 67.8% (p < 0.01) from 2011 to 2013 despite overall arrest rates remaining stable throughout Tijuana. For each successive year, we identified a high degree of spatial association between the location of self-reported and official arrests (p < 0.05). Conclusion Two independent data sources suggest that intensity of drug law enforcement had risen in Tijuana despite the promulgation of a public health-oriented drug policy reform. The highest concentrations of arrests were in areas traditionally characterized by higher rates of drug crime. High correlation between self-reported and official arrest data underscores opportunities for future research on the role of policing as a structural determinant of public health. PMID:27767367

Patterns and Prevalence of Arrest in a Statewide Cohort of Mental Health Care Consumers

PubMed Central

Fisher, William H.; Roy-Bujnowski, Kristen M.; Grudzinskas, Albert J.; Clayfield, Jonathan C.; Banks, Steven M.; Wolff, Nancy

2010-01-01

Objective Although criminal justice involvement among persons with severe mental illness is a much discussed topic, few large-scale studies systematically describe the patterns and prevalence of arrest in this population. This study examined rates, patterns, offenses, and sociodemographic correlates of arrest in a large cohort of mental health service recipients. Methods The arrest records of 13,816 individuals receiving services from the Massachusetts Department of Mental Health from 1991 to 1992 were examined over roughly a ten-year period. Bivariate relationships between sociodemographic factors and arrest were also examined. Results About 28 percent of the cohort experienced at least one arrest. The most common charges were crimes against public order followed by serious violent offenses and minor property crime. The number of arrests per individual ranged from one to 71. Five percent of arrestees (roughly 1.5 percent of the cohort) accounted for roughly 17 percent of arrests. The proportion of men arrested was double that of women. Persons 18 to 25 years of age had a 50 percent chance of at least one arrest. This rate declined with age but did so unevenly across offense types. Conclusions The likelihood of arrest appeared substantial among persons with severe mental illness, but the bulk of offending appeared concentrated in a small group of persons and among persons with sociodemographic features similar to those of offenders in the general population. Data such as these could provide a platform for designing jail diversion and other services to reduce both initial and repeat offending among persons with serious mental illness. PMID:17085611

14 CFR 1203b.103 - Arrest authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Arrest authority. 1203b.103 Section 1203b.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND USE OF FORCE BY NASA SECURITY FORCE PERSONNEL § 1203b.103 Arrest authority. (a) NASA security...

14 CFR 1203b.103 - Arrest authority.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Arrest authority. 1203b.103 Section 1203b.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND USE OF FORCE BY NASA SECURITY FORCE PERSONNEL § 1203b.103 Arrest authority. (a) NASA security...

14 CFR 1203b.103 - Arrest authority.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Arrest authority. 1203b.103 Section 1203b.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND USE OF FORCE BY NASA SECURITY FORCE PERSONNEL § 1203b.103 Arrest authority. (a) NASA security...

14 CFR 1203b.103 - Arrest authority.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Arrest authority. 1203b.103 Section 1203b.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND USE OF FORCE BY NASA SECURITY FORCE PERSONNEL § 1203b.103 Arrest authority. (a) NASA security...

10 CFR 1047.5 - Exercise of arrest authority-general guidelines.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Exercise of arrest authority-general guidelines. 1047.5 Section 1047.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS General Provisions § 1047.5 Exercise of arrest authority—general...

10 CFR 1047.5 - Exercise of arrest authority-general guidelines.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Exercise of arrest authority-general guidelines. 1047.5 Section 1047.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS General Provisions § 1047.5 Exercise of arrest authority—general...

10 CFR 1047.5 - Exercise of arrest authority-general guidelines.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Exercise of arrest authority-general guidelines. 1047.5 Section 1047.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS General Provisions § 1047.5 Exercise of arrest authority—general...

10 CFR 1047.5 - Exercise of arrest authority-general guidelines.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Exercise of arrest authority-general guidelines. 1047.5 Section 1047.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS General Provisions § 1047.5 Exercise of arrest authority—general...

10 CFR 1047.5 - Exercise of arrest authority-general guidelines.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Exercise of arrest authority-general guidelines. 1047.5 Section 1047.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS General Provisions § 1047.5 Exercise of arrest authority—general...

Gender and Relational-Distance Effects in Arrests for Domestic Violence

ERIC Educational Resources Information Center

Lally, William; DeMaris, Alfred

2012-01-01

This study tests two hypotheses regarding factors affecting arrest of the perpetrator in domestic violence incidents. Black's relational-distance thesis is that the probability of arrest increases with increasing relational distance between perpetrator and victim. Klinger's leniency principle suggests that the probability of arrest is lower for…

Postcardiac Arrest Management.

PubMed

Rittenberger, Jon C; Doshi, Ankur A; Reynolds, Joshua C

2015-08-01

Cardiac arrest afflicts more than 300,000 persons annually in North America alone. Advances in systematic, regimented postresuscitation care have lowered mortality and improved neurologic outcomes in select cohorts of patients over the last decade. Postcardiac arrest care now comprises its own link in the chain of survival. For most patients, high-quality postcardiac arrest care begins in the Emergency Department. This article reviews the evidence and offers treatment strategies for the key components of postcardiac arrest care. Copyright © 2015 Elsevier Inc. All rights reserved.

Inducing Therapeutic Hypothermia in Cardiac Arrest Caused by Lightning Strike.

PubMed

Scantling, Dane; Frank, Brian; Pontell, Mathew E; Medinilla, Sandra

2016-09-01

Only limited clinical scenarios are grounds for induction of therapeutic hypothermia. Its use in traumatic cardiac arrests, including those from lightning strikes, is not well studied. Nonshockable cardiac arrest rhythms have only recently been included in resuscitation guidelines. We report a case of full neurological recovery with therapeutic hypothermia after a lightning-induced pulseless electrical activity cardiac arrest in an 18-year-old woman. We also review the important pathophysiology of lightning-induced cardiac arrest and neurologic sequelae, elaborate upon the mechanism of therapeutic hypothermia, and add case-based evidence in favor of the use of targeted temperature management in lightning-induced cardiac arrest. Copyright © 2016 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Evidence for arrested bone formation during spaceflight

NASA Technical Reports Server (NTRS)

Turner, R. T.; Bobyn, J. D.; Duvall, P.; Morey, E. R.; Baylink, D. J.; Spector, M.

1982-01-01

Addressing the question of whether the bone formed in space is unusual, the morphology of bone made at the tibial diaphysis of rats before, during, and after spaceflight is studied. Evidence of arrest lines in the bone formed in space is reported suggesting that bone formation ceases along portions of the periosteum during spaceflight. Visualized by microradiography, the arrest lines are shown to be less mineralized than the surrounding bone matrix. When viewed by scanning electron microscopy, it is seen that bone fractures more readily at the site of an arrest line. These observations are seen as suggesting that arrest lines are a zone of weakness and that their formation may result in decreased bone strength in spite of normalization of bone formation after flight. The occurrence, location, and morphology of arrest lines are seen as suggesting that they are a visible result of the phenomenon of arrested bone formation.

Arrest types and co-occurring disorders in persons with schizophrenia or related psychoses.

PubMed

McCabe, Patrick J; Christopher, Paul P; Druhn, Nicholas; Roy-Bujnowski, Kristen M; Grudzinskas, Albert J; Fisher, William H

2012-07-01

This study examined the patterns of criminal arrest and co-occurring psychiatric disorders among individuals with schizophrenia or related psychosis that were receiving public mental health services and had an arrest history. Within a 10-year period, 65% of subjects were arrested for crimes against public order, 50% for serious violent crimes, and 45% for property crimes. The presence of any co-occurring disorder increased the risk of arrest for all offense categories. For nearly all offense types, antisocial personality disorder and substance use disorders conferred the greatest increase in risk for arrest. Among anxiety disorders, post-traumatic stress disorder was associated with a greater risk of arrest for serious violent crimes but not other offense types. Criminal risk assessments and clinical management in this population should focus on co-occurring antisocial personality disorder and substance use disorders in addition to other clinical and non-clinical factors.

10 CFR 1049.5 - Exercise of arrest authority-General guidelines.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Exercise of arrest authority-General guidelines. 1049.5 Section 1049.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.5 Exercise of arrest authority...

10 CFR 1049.5 - Exercise of arrest authority-General guidelines.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Exercise of arrest authority-General guidelines. 1049.5 Section 1049.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.5 Exercise of arrest authority...

10 CFR 1049.5 - Exercise of arrest authority-General guidelines.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Exercise of arrest authority-General guidelines. 1049.5 Section 1049.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.5 Exercise of arrest authority...

10 CFR 1049.5 - Exercise of arrest authority-General guidelines.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Exercise of arrest authority-General guidelines. 1049.5 Section 1049.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.5 Exercise of arrest authority...

10 CFR 1049.5 - Exercise of arrest authority-General guidelines.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Exercise of arrest authority-General guidelines. 1049.5 Section 1049.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.5 Exercise of arrest authority...

Explaining Discrepancies in Arrest Rates between Black and White Male Juveniles

ERIC Educational Resources Information Center

Fite, Paula J.; Wynn, Porche'; Pardini, Dustin A.

2009-01-01

The authors investigated discrepancies in arrest rates between Black and White male juveniles by examining the role of early risk factors for arrest. Two hypotheses were evaluated: (a) Disproportionate minority arrest is due to increased exposure to early risk factors, and (b) a differential sensitivity to early risk factors contributes to…

33 CFR 150.619 - What are the fall arrest system requirements?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false What are the fall arrest system... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Fall Arrest § 150.619 What are the fall arrest system requirements? (a) The deepwater port operator must ensure that...

33 CFR 150.619 - What are the fall arrest system requirements?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false What are the fall arrest system... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Fall Arrest § 150.619 What are the fall arrest system requirements? (a) The deepwater port operator must ensure that...

33 CFR 150.619 - What are the fall arrest system requirements?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false What are the fall arrest system... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Fall Arrest § 150.619 What are the fall arrest system requirements? (a) The deepwater port operator must ensure that...

33 CFR 150.619 - What are the fall arrest system requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false What are the fall arrest system... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Fall Arrest § 150.619 What are the fall arrest system requirements? (a) The deepwater port operator must ensure that...

33 CFR 150.619 - What are the fall arrest system requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What are the fall arrest system... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Fall Arrest § 150.619 What are the fall arrest system requirements? (a) The deepwater port operator must ensure that...

25 CFR 11.301 - Arrests.

Code of Federal Regulations, 2011 CFR

2011-04-01

... AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Criminal Procedure § 11.301 Arrests. (a) Arrest is the taking of a person into police custody in order that he or she may be held to answer for a criminal offense. (b) No law enforcement officer shall arrest...

30 CFR 75.521 - Lightning arresters; ungrounded and exposed power conductors and telephone wires.

Code of Federal Regulations, 2013 CFR

2013-07-01

... of the point where the circuit enters the mine. Lightning arresters shall be connected to a low... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Lightning arresters; ungrounded and exposed... Electrical Equipment-General § 75.521 Lightning arresters; ungrounded and exposed power conductors and...

30 CFR 75.521 - Lightning arresters; ungrounded and exposed power conductors and telephone wires.

Code of Federal Regulations, 2012 CFR

2012-07-01

... of the point where the circuit enters the mine. Lightning arresters shall be connected to a low... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Lightning arresters; ungrounded and exposed... Electrical Equipment-General § 75.521 Lightning arresters; ungrounded and exposed power conductors and...

30 CFR 75.521 - Lightning arresters; ungrounded and exposed power conductors and telephone wires.

Code of Federal Regulations, 2014 CFR

2014-07-01

... of the point where the circuit enters the mine. Lightning arresters shall be connected to a low... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Lightning arresters; ungrounded and exposed... Electrical Equipment-General § 75.521 Lightning arresters; ungrounded and exposed power conductors and...

Myocardial Dysfunction and Shock after Cardiac Arrest

PubMed Central

Jentzer, Jacob C.; Chonde, Meshe D.; Dezfulian, Cameron

2015-01-01

Postarrest myocardial dysfunction includes the development of low cardiac output or ventricular systolic or diastolic dysfunction after cardiac arrest. Impaired left ventricular systolic function is reported in nearly two-thirds of patients resuscitated after cardiac arrest. Hypotension and shock requiring vasopressor support are similarly common after cardiac arrest. Whereas shock requiring vasopressor support is consistently associated with an adverse outcome after cardiac arrest, the association between myocardial dysfunction and outcomes is less clear. Myocardial dysfunction and shock after cardiac arrest develop as the result of preexisting cardiac pathology with multiple superimposed insults from resuscitation. The pathophysiology involves cardiovascular ischemia/reperfusion injury and cardiovascular toxicity from excessive levels of inflammatory cytokine activation and catecholamines, among other contributing factors. Similar mechanisms occur in myocardial dysfunction after cardiopulmonary bypass, in sepsis, and in stress-induced cardiomyopathy. Hemodynamic stabilization after resuscitation from cardiac arrest involves restoration of preload, vasopressors to support arterial pressure, and inotropic support if needed to reverse the effects of myocardial dysfunction and improve systemic perfusion. Further research is needed to define the role of postarrest myocardial dysfunction on cardiac arrest outcomes and identify therapeutic strategies. PMID:26421284

Myocardial Dysfunction and Shock after Cardiac Arrest.

PubMed

Jentzer, Jacob C; Chonde, Meshe D; Dezfulian, Cameron

2015-01-01

Postarrest myocardial dysfunction includes the development of low cardiac output or ventricular systolic or diastolic dysfunction after cardiac arrest. Impaired left ventricular systolic function is reported in nearly two-thirds of patients resuscitated after cardiac arrest. Hypotension and shock requiring vasopressor support are similarly common after cardiac arrest. Whereas shock requiring vasopressor support is consistently associated with an adverse outcome after cardiac arrest, the association between myocardial dysfunction and outcomes is less clear. Myocardial dysfunction and shock after cardiac arrest develop as the result of preexisting cardiac pathology with multiple superimposed insults from resuscitation. The pathophysiology involves cardiovascular ischemia/reperfusion injury and cardiovascular toxicity from excessive levels of inflammatory cytokine activation and catecholamines, among other contributing factors. Similar mechanisms occur in myocardial dysfunction after cardiopulmonary bypass, in sepsis, and in stress-induced cardiomyopathy. Hemodynamic stabilization after resuscitation from cardiac arrest involves restoration of preload, vasopressors to support arterial pressure, and inotropic support if needed to reverse the effects of myocardial dysfunction and improve systemic perfusion. Further research is needed to define the role of postarrest myocardial dysfunction on cardiac arrest outcomes and identify therapeutic strategies.

Teenage cardiac arrest following abuse of synthetic cannabis.

PubMed

Davis, C; Boddington, D

2015-10-01

The cardiac effects of many illegal substances (cocaine, methadone) have previously been well described [1,2]. However the association between synthetic cannabis and cardiac arrest is less well documented. Here we describe an out-of-hospital cardiac arrest in a previously healthy 16-year-old female associated with the use of inhaled synthetic cannabis. An electronic systematic search of online databases PubMed and Embase was performed using keywords, "synthetic cannabis death" and "cardiac arrest". In this case study a previously healthy 16-year-old had a cardiac arrest after synthetic cannabis use. Despite extensive investigations no other cause for her arrest was found. To the best of our knowledge there has been one previous case report of cardiac arrest following synthetic cannabis use in a 56-year-old man [3]. This case report augments the relationship between synthetic cannabis and cardiac arrest in the medical community. More awareness surrounding the risk of synthetic cannabinoids is warranted. Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

An audit of in-hospital cardiopulmonary resuscitation in a teaching hospital in Saudi Arabia: A retrospective study

PubMed Central

Kaki, Abdullah Mohammed; Alghalayini, Kamal Waheeb; Alama, Mohamed Nabil; Almazroaa, Adnan Abdullah; Khathlan, Norah Abdullah A.; Sembawa, Hassan; Ouseph, Beena M.

2017-01-01

Objectives: Data reflecting cardiopulmonary resuscitation (CPR) efforts in Saudi Arabia are limited. In this study, we analyzed the characteristics, and estimated the outcome, of in-hospital CPR in a teaching hospital in Saudi Arabia over 4 years. Methods: A retrospective, observational study was conducted between January 2009 and December 2012 and included 4361 patients with sudden cardiopulmonary arrest. Resuscitation forms were reviewed. Demographic data, resuscitation characteristics, and survival outcomes were recorded. Results: The mean ± standard deviation age of arrested patient was 40 ± 31 years. The immediate survival rate was 64%, 43% at 24 h, and 30% at discharge. The death rate was 70%. Respiratory type of arrest, time and place of arrest, short duration of arrest, witnessed arrest, the use of epinephrine and atropine boluses, and shockable arrhythmias were associated with higher 24-h survival rates. A low survival rate was found among patients with cardiac types of arrest, and those with a longer duration of arrest, pulseless electrical activity, and asystole. Comorbidities were present in 3786 patients with cardiac arrest and contributed to a poor survival rate (P < 0.001). Conclusions: The study confirms the findings of previously published studies in highly developed countries and provides some reflection on the practice of resuscitation in Saudi Arabia. PMID:29033721

TU-G-213-00: The International Electrotechnical Commission (IEC): What Is It and Why Should Medical Physicists Care?

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The International Electrotechnical Commission (IEC) writes standards that manufacturers of electrical equipment must comply with. Medical electrical equipment, such as medical imaging, radiation therapy, and radiation dosimetry devices, fall under Technical Committee 62. Of particular interest to medical physicists are the standards developed within Subcommittees (SC) 62B, which addresses diagnostic radiological imaging equipment, and 62C, which addresses equipment for radiation therapy, nuclear medicine and dosimetry. For example, a Working Group of SC 62B is responsible for safety and quality assurance standards for CT scanners and a Working Group of SC 62C is responsible for standards that set requirements for dosimetricmore » safety and accuracy of linacs and proton accelerators. IEC standards thus have an impact on every aspect of a medical physicist’s job, including equipment testing, shielding design, room layout, and workflow. Consequently, it is imperative that US medical physicists know about existing standards, as well as have input on those under development or undergoing revision. The structure of the IEC and current standards development work will be described in detail. The presentation will explain how US medical physicists can learn about IEC standards and contribute to their development. Learning Objectives: Learn about the structure of the IEC and the influence that IEC standards have on the design of equipment for radiology and radiation therapy. Learn about the mechanisms by which the US participates in the development and revision of standards. Understand the specific requirements of several standards having direct relevance to diagnostic and radiation therapy physicists.« less

Curriculum for education and training of medical physicists in nuclear medicine: recommendations from the EANM Physics Committee, the EANM Dosimetry Committee and EFOMP.

PubMed

Del Guerra, Alberto; Bardies, Manuel; Belcari, Nicola; Caruana, Carmel J; Christofides, Stelios; Erba, Paola; Gori, Cesare; Lassmann, Michael; Lonsdale, Markus Nowak; Sattler, Bernhard; Waddington, Wendy

2013-03-01

To provide a guideline curriculum covering theoretical and practical aspects of education and training for Medical Physicists in Nuclear Medicine within Europe. National training programmes of Medical Physics, Radiation Physics and Nuclear Medicine physics from a range of European countries and from North America were reviewed and elements of best practice identified. An independent panel of experts was used to achieve consensus regarding the content of the curriculum. Guidelines have been developed for the specialist theoretical knowledge and practical experience required to practice as a Medical Physicist in Nuclear Medicine in Europe. It is assumed that the precondition for the beginning of the training is a good initial degree in Medical Physics at master level (or equivalent). The Learning Outcomes are categorised using the Knowledge, Skill and Competence approach along the lines recommended by the European Qualifications Framework. The minimum level expected in each topic in the theoretical knowledge and practical experience sections is intended to bring trainees up to the requirements expected of a Medical Physicist entering the field of Nuclear Medicine. This new joint EANM/EFOMP European guideline curriculum is a further step to harmonise specialist training of Medical Physicists in Nuclear Medicine within Europe. It provides a common framework for national Medical Physics societies to develop or benchmark their own curricula. The responsibility for the implementation and accreditation of these standards and guidelines resides within national training and regulatory bodies. Copyright © 2012 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Physicists' views on hadrontherapy: a survey of members of the Italian Association of Medical Physics (AIFM).

PubMed

Giandini, Tommaso; Tenconi, Chiara; Carrara, Mauro; Ciocca, Mario; Russo, Stefania; Panaino, Costanza M V; Cattani, Federica; Ciardo, Delia; Morlino, Sara; Avuzzi, Barbara; Bedini, Nice; Villa, Sergio; Marvaso, Giulia; Romanelli, Paola; Hasegawa, Azusa; Vischioni, Barbara; Valvo, Francesca; Jereczek-Fossa, Barbara A; Orecchia, Roberto; Valdagni, Riccardo; Pignoli, Emanuele

2017-09-18

This study was based on a survey to investigate perceptions of hadrontherapy of the members of the Italian Association of Medical Physics (AIFM). The survey was digitally submitted to the 991 members between the end of January and the beginning of April 2016. A 19-item questionnaire was designed focusing on advantages and disadvantages of hadrontherapy, current status and possible future improvements, and need and opportunities for future investments in Italy and abroad. Information about professional qualifications, main fields of clinical involvement and specific competencies of the respondents was also collected. The survey was completed by 121 AIFM members (response rate 12.2%). In the answers collected, it was shown that medical physicists expressed interest in hadrontherapy mainly for reasons of personal interest rather than for professional needs (90% ± 2.5% vs. 52% ± 4.3% of the respondents, respectively), with a good knowledge of the related basic aspects as well as of the pros and cons of its application. However, poor knowledge of the current status of hadrontherapy was observed among the medical physicists not directly involved at a professional level, who were less than 3% of the physicists working in radiotherapy. In light of these results, the implementation of new training and education initiatives should be devised to promote a deeper and global knowledge of hadrontherapy-related issues, not only from a theoretical point of view but also in practical terms. Moreover, a close collaboration between highly specialized medical physicists employed in hadrontherapy centers and others in oncology hospitals should be -encouraged.

Enforcement following 0.08% BAC law change: sex-specific consequences of changing arrest practices?

PubMed

Schwartz, Jennifer; Davaran, Ardavan

2013-10-01

This research evaluated effects of stricter 0.08% BAC drunken driving law on changes in sex-specific DUI arrest rates, controlling for increased law enforcement resources and shifts in DUI-related behaviors. Another main purpose, the study assessed female/male differences in arrest increases due to broader enforcement standards and efforts. Panel data was assembled for 24 states over 1990-2007 on DUI arrests, alcohol policy, law enforcement resources, drinking and drunken driving prevalence. Two-way fixed-effects seemingly unrelated regression models predicted female versus male changes in DUI arrests following implementation of lower legal limits of intoxication, net controls. Findings suggest, first, that a broader legal definition of drunken driving intending to officially sanction less serious offenders (0.08% vs. 0.10% BAC) was associated with increased DUI arrests for both sexes. Second, growth in specialized DUI-enforcement units also was related to increased arrests. Whereas male and female arrest trends were equally affected by the direct net-widening effects of 0.08% BAC alcohol-policy, specialized DUI-enforcement efforts to dig deeper into the offender-pool had stronger arrest-producing effects on females, particularly prior to law change. Specifying how changes in law and enforcement resources affect arrest outcomes is an important pre-cursor to alcohol-policy analyses of effectiveness. A potential unintended consequence, effects of law and enforcement may differ across population segments. Copyright © 2013 Elsevier Ltd. All rights reserved.

Cardiac arrest while exercising on mountains in national or provincial parks: A national observational study from 2012 to 2015.

PubMed

Jung, Eujene; Park, Jeong Ho; Kong, So Yeon; Hong, Ki Jeong; Ro, Young Sun; Song, Kyoung Jun; Ryu, Hyun Ho; Shin, Sang Do

2017-12-20

Previous studies on cardiac arrest in mountainous areas were focused on environmental features such as altitude and temperature. However, those are limited to factors affecting the prognosis of patients after cardiac arrest. We analyzed the cardiac arrests in national or provincial parks located in the mountains and determined the factors affecting the prognosis of patients after cardiac arrest. This study included all emergency medical service (EMS) treated patients over the age of 40 experiencing out-of-hospital cardiac arrests (OHCAs) of presumed cardiac etiology during exercise, between January 2012 and December 2015. The main focus of interest was the location of cardiac arrest occurrence (national mountain parks and provincial parks vs. other sites). The main outcome was survival to discharge and multivariable logistic regression was performed to adjust for possible confounding effects. A total 1835 patients who suffered a cardiac arrest while exercising were included. From these, 68 patients experienced cardiac arrest in national or provincial parks, and 1767 occurred in other locations. The unadjusted and adjusted ORs (95% CI) for a good cerebral performance scale (CPC) were 0.09 (0.01-0.63) and 0.08(0.01-0.56), survival discharges were 0.13(0.03-0.53) and 0.11 (0.03-0.48). Cardiac arrests occurring while exercising in the mountainous areas have worse prognosis compared to alternative locations. Copyright © 2017. Published by Elsevier Inc.

Echocardiography in cardiac arrest: An emergency medicine review.

PubMed

Long, Brit; Alerhand, Stephen; Maliel, Kurian; Koyfman, Alex

2018-03-01

Cardiac arrest management primarily focuses on optimal chest compressions and early defibrillation for shockable cardiac rhythms. Non-shockable rhythms such as pulseless electrical activity (PEA) and asystole present challenges in management. Point-of-care ultrasound (POCUS) in cardiac arrest is promising. This review provides a focused assessment of POCUS in cardiac arrest, with an overview of transthoracic (TTE) and transesophageal echocardiogram (TEE), uses in arrest, and literature support. Cardiac arrest can be distinguished between shockable and non-shockable rhythms, with management varying based on the rhythm. POCUS provides a diagnostic and prognostic tool in the emergency department (ED), which may improve accuracy in clinical decision-making. Several protocols incorporate POCUS based on different cardiac views. TTE includes parasternal long axis, parasternal short axis, apical 4-chamber, and subxiphoid views, which may be used in cardiac arrest for diagnosis of underlying cause and potential prognostication. TEE is conducted by inserting the probe into the esophagus of intubated patients, with several studies evaluating its use in cardiac arrest. It is associated with few adverse effects, while allowing continued compressions (and evaluation of those compressions) and not interrupting resuscitation efforts. POCUS is a valuable diagnostic and prognostic tool in cardiac arrest, with recent literature supporting its diagnostic ability. TTE can guide resuscitation efforts dependent on the rhythm, though TTE should not interrupt other resuscitation measures. TEE can be useful during arrest, but further studies based in the ED are needed. Published by Elsevier Inc.

Post-resuscitation care following out-of-hospital and in-hospital cardiac arrest.

PubMed

Girotra, Saket; Chan, Paul S; Bradley, Steven M

2015-12-01

Cardiac arrest is a leading cause of death in developed countries. Although a majority of cardiac arrest patients die during the acute event, a substantial proportion of cardiac arrest deaths occur in patients following successful resuscitation and can be attributed to the development of post-cardiac arrest syndrome. There is growing recognition that integrated post-resuscitation care, which encompasses targeted temperature management (TTM), early coronary angiography and comprehensive critical care, can improve patient outcomes. TTM has been shown to improve survival and neurological outcome in patients who remain comatose especially following out-of-hospital cardiac arrest due to ventricular arrhythmias. Early coronary angiography and revascularisation if needed may also be beneficial during the post-resuscitation phase, based on data from observational studies. In addition, resuscitated patients usually require intensive care, which includes mechanical ventilator, haemodynamic support and close monitoring of blood gases, glucose, electrolytes, seizures and other disease-specific intervention. Efforts should be taken to avoid premature withdrawal of life-supporting treatment, especially in patients treated with TTM. Given that resources and personnel needed to provide high-quality post-resuscitation care may not exist at all hospitals, professional societies have recommended regionalisation of post-resuscitation care in specialised 'cardiac arrest centres' as a strategy to improve cardiac arrest outcomes. Finally, evidence for post-resuscitation care following in-hospital cardiac arrest is largely extrapolated from studies in patients with out-of-hospital cardiac arrest. Future studies need to examine the effectiveness of different post-resuscitation strategies, such as TTM, in patients with in-hospital cardiac arrest. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Anesthesia-related cardiac arrest in children: the Thai Anesthesia Incidents Study (THAI Study).

PubMed

Bunchungmongkol, Nutchanart; Punjasawadwong, Yodying; Chumpathong, Saowapark; Somboonviboon, Wanna; Suraseranivongse, Suwannee; Vasinanukorn, Mayuree; Srisawasdi, Surirat; Thienthong, Somboon; Pranootnarabhal, Tharnthip

2009-04-01

The Thai Anesthesia Incidents study (THAI Study) is the first national study of anesthesia outcomes during anesthesia practice in Thailand. The authors extracted data of 25,098 pediatric cases from the THAI Study in order to examine the incidence, suspected causes, contributory factors, and suggested corrective strategies associated with anesthesia-related cardiac arrest. A multi-centered prospective descriptive study was conducted among 20 hospitals across Thailand over a year between March 1, 2003 and February 28, 2004. Data of cardiac arrests in children aged 15 years and younger were collected during anesthesia, in the recovery room and 24 hours postoperative period, and reviewed independently by at least two reviewers. Incidence of anesthesia- related cardiac arrest was 5.1 per 10,000 anesthetics, with 46% mortality rate. Infants accounted for 61% of cases. Incidences of overall cardiac arrest and anesthesia-related arrest were significantly higher in infants than older children and in children with ASA physical status 3-5 than those with ASA physical status 1-2. Most of the anesthesia-related arrests occurred in the operating room (61%) during induction or maintenance of anesthesia (84%). Respiratory-related cardiac arrest was the most common suspected cause of anesthesia-related cardiac arrest. Improving supervision, additional training, practice guidelines, efficient blood bank, equipment maintenance, and quality assurance monitoring are suggested corrective strategies to improve the quality of care in pediatric anesthesia. The incidence of anesthesia-related cardiac arrest was 5.1:10,000 anesthetics. Major risk factors were children younger than 1 year of age and ASA 3-5. The identifications of airway management and medication-related problems as the main causes of anesthesia-related cardiac arrest have important implications for preventive strategies.

Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage

PubMed Central

Manson, Margaret M.

2013-01-01

The chemopreventive agent curcumin has anti-proliferative effects in many tumour types, but characterization of cell cycle arrest, particularly with physiologically relevant concentrations, is still incomplete. Following oral ingestion, the highest concentrations of curcumin are achievable in the gut. Although it has been established that curcumin induces arrest at the G2/M stage of the cell cycle in colorectal cancer lines, it is not clear whether arrest occurs at the G2/M transition or in mitosis. To elucidate the precise stage of arrest, we performed a direct comparison of the levels of curcumin-induced G2/M boundary and mitotic arrest in eight colorectal cancer lines (Caco-2, DLD-1, HCA-7, HCT116p53+/+, HCT116p53–/–, HCT116p21–/–, HT-29 and SW480). Flow cytometry confirmed that these lines underwent G2/M arrest following treatment for 12h with clinically relevant concentrations of curcumin (5–10 μM). In all eight lines, the majority of this arrest occurred at the G2/M transition, with a proportion of cells arresting in mitosis. Examination of the mitotic index using fluorescence microscopy showed that the HCT116 and Caco-2 lines exhibited the highest levels of curcumin-induced mitotic arrest. Image analysis revealed impaired mitotic progression in all lines, exemplified by mitotic spindle abnormalities and defects in chromosomal congression. Pre-treatment with inhibitors of the DNA damage signalling pathway abrogated curcumin-induced mitotic arrest, but had little effect at the G2/M boundary. Moreover, pH2A.X staining seen in mitotic, but not interphase, cells suggests that this aberrant mitosis results in DNA damage. PMID:23125222

Drinking and driving and perceptions of arrest risk among California drivers: Relationships with DUI arrests in their city of residence.

PubMed

MacLeod, Kara E; Karriker-Jaffe, Katherine J; Satariano, William A; Kelley-Baker, Tara; Lacey, John H; Ragland, David R

2017-08-18

Addressing drinking and driving remains a challenge in the United States. The present study aims to provide feedback on driving under the influence (DUI) in California by assessing whether drinking and driving behavior is associated with the DUI arrest rates in the city in which the driver lives; whether this is due to perceptions that one can get arrested for this behavior; and whether this differed by those drivers who would be most affected by deterrence efforts (those most likely to drink outside the home). This study consisted of a 2012 roadside survey of 1,147 weekend nighttime drivers in California. City DUI arrest rates for 2009-2011 were used as an indicator of local enforcement efforts. Population average logistic modeling was conducted modeling the odds of perceived high arrest likelihood for DUI and drinking and driving behavior within the past year. As the DUI arrest rates for the city in which the driver lives increased, perceived high risk of DUI arrest increased. There was no significant relationship between either city DUI arrest rates or perceived high risk of DUI arrest with self-reported drinking and driving behavior in the full sample. Among a much smaller sample of those most likely to drink outside the home, self-reported drinking and driving behavior was negatively associated with DUI arrests rates in their city of residence but this was not mediated by perceptions. The results of the present study suggest that perceptions are correlated with one aspect of DUI efforts in one's community. Those who were more likely to drink outside the home could be behaviorally influenced by these efforts.

Temporal trends in coverage of historical cardiac arrests using a volunteer-based network of automated external defibrillators accessible to laypersons and emergency dispatch centers.

PubMed

Hansen, Carolina Malta; Lippert, Freddy Knudsen; Wissenberg, Mads; Weeke, Peter; Zinckernagel, Line; Ruwald, Martin H; Karlsson, Lena; Gislason, Gunnar Hilmar; Nielsen, Søren Loumann; Køber, Lars; Torp-Pedersen, Christian; Folke, Fredrik

2014-11-18

Although increased dissemination of automated external defibrillators (AEDs) has been associated with more frequent AED use, the trade-off between the number of deployed AEDs and coverage of cardiac arrests remains unclear. We investigated how volunteer-based AED dissemination affected public cardiac arrest coverage in high- and low-risk areas. All public cardiac arrests (1994-2011) and all registered AEDs (2007-2011) in Copenhagen, Denmark, were identified and geocoded. AED coverage of cardiac arrests was defined as historical arrests ≤100 m from an AED. High-risk areas were defined as those with ≥1 arrest every 2 years and accounted for 1.0% of the total city area. Of 1864 cardiac arrests, 18.0% (n=335) occurred in high-risk areas throughout the study period. From 2007 to 2011, the number of AEDs and the corresponding coverage of cardiac arrests increased from 36 to 552 and from 2.7% to 32.6%, respectively. The corresponding increase for high-risk areas was from 1 to 30 AEDs and coverage from 5.7% to 51.3%, respectively. Since the establishment of the AED network (2007-2011), few arrests (n=55) have occurred ≤100 m from an AED with only 14.5% (n=8) being defibrillated before the arrival of emergency medical services. Despite the lack of a coordinated public access defibrillation program, the number of AEDs increased 15-fold with a corresponding increase in cardiac arrest coverage from 2.7% to 32.6% over a 5-year period. The highest increase in coverage was observed in high-risk areas (from 5.7% to 51.3%). AED networks can be used as useful tools to optimize AED placement in community settings. © 2014 American Heart Association, Inc.

Early Presence of Sleep Spindles on Electroencephalography Is Associated With Good Outcome After Pediatric Cardiac Arrest.

PubMed

Ducharme-Crevier, Laurence; Press, Craig A; Kurz, Jonathan E; Mills, Michele G; Goldstein, Joshua L; Wainwright, Mark S

2017-05-01

The role of sleep architecture as a biomarker for prognostication after resuscitation from cardiac arrest in children hospitalized in an ICU remains poorly defined. We sought to investigate the association between features of normal sleep architecture in children after cardiac arrest and a favorable neurologic outcome at 6 months. Retrospective review of medical records and continuous electroencephalography monitoring. Cardiac and PICU of a tertiary children's hospital. All patients from 6 months to 18 years old resuscitated from cardiac arrest who underwent continuous electroencephalography monitoring in the first 24 hours after in- or out-of-hospital cardiac arrest from January 2010 to June 2015. None. Thirty-four patients underwent continuous electroencephalography monitoring after cardiac arrest. The median age was 6.1 years (interquartile range, 1.5-12.5 yr), 20 patients were male (59%). Most cases (n = 23, 68%) suffered from in-hospital cardiac arrest. Electroencephalography monitoring was initiated a median of 9.3 hours (5.8-14.9 hr) after return of spontaneous circulation, for a median duration of 14.3 hours (6.0-16.0 hr) within the first 24-hour period after the cardiac arrest. Five patients had normal spindles, five had abnormal spindles, and 24 patients did not have any sleep architecture. The presence of spindles was associated with a favorable neurologic outcome at 6-month postcardiac arrest (p = 0.001). Continuous electroencephalography monitoring can be used in children to assess spindles in the ICU. The presence of spindles on continuous electroencephalography monitoring in the first 24 hours after resuscitation from cardiac arrest is associated with a favorable neurologic outcome. Assessment of sleep architecture on continuous electroencephalography after cardiac arrest could improve outcome prediction.

Epidemiology of Cardiac Arrest During Hospitalization for Delivery in Canada: A Nationwide Study.

PubMed

Balki, Mrinalini; Liu, Shiliang; León, Juan Andrés; Baghirzada, Leyla

2017-03-01

Cardiac arrest in pregnancy is a rare and devastating condition with high mortality and morbidity. The objective of this study was to generate information about maternal cardiac arrest in Canada by examining the frequency, temporal incidence, associated conditions, potential etiologies, and survival rates. This retrospective population-based study used hospitalization data from the discharge abstract database of the Canadian Institute for Health Information relating to obstetric deliveries in Canada from April 1, 2002, to March 31, 2015. The data were accessed through the Public Health Agency of Canada's (PHAC) Canadian Perinatal Surveillance System. Cases of cardiac arrest were identified using the diagnostic and intervention codes from the International Statistical Classification of Diseases and the Canadian Classification of Health Interventions, respectively. Data on patient demographics, medical and obstetrical conditions, and potential etiologies of cardiac arrest were collected. Multivariable logistic regression analysis was used to identify conditions associated with cardiac arrest. There were 286 cases of maternal cardiac arrest among 3,568,597 hospitalizations for delivery during the 13-year period. A total of 204 (71.3%) women survived to hospital discharge (95% confidence interval, 65.7%-76.5%). There was no significant variation in the incidence of cardiac arrest or survival from arrest over time or across provinces. Among the pre-existing conditions, hypertensive disorders of pregnancy, gestational diabetes, malignancy, and diseases of the respiratory and nervous system were found to be significantly associated with cardiac arrest. Among the obstetrical conditions, placental abnormalities and polyhydramnios were associated with cardiac arrest. The common potential etiologies included postpartum hemorrhage, heart failure, amniotic fluid embolism, and complications of anesthesia. In this first Canadian study, the incidence of cardiac arrest during pregnancy was found to be 1:12,500 deliveries. The survival rate reported in our study is higher than reported previously in other countries. Our study findings contribute to better inform the development and implementation of policies and programs in an effort to prevent and manage this condition.

Women's perspectives on the context of violence and role of police in their intimate partner violence arrest experiences.

PubMed

Li, Simiao; Levick, Ani; Eichman, Adelaide; Chang, Judy C

2015-02-01

Intimate partner violence (IPV) accounts for up to 50% of all calls to police. In an effort to standardize arrest criteria, mandatory arrest laws were established. It is unclear whether subsequent increased rates of female arrest are due to greater recognition of female IPV perpetrators or of women acting in self-defense. This study aims to understand the context and consequences of IPV-related arrest from perspectives of women arrested in a single metropolitan area. Semi-structured qualitative interviews were conducted with women arrested and court-ordered to attend IPV education groups at a women's shelter in the Northeast United States. Interviews addressed circumstances surrounding arrest, experience with past violence, and reasoning regarding use of partner violence. Two researchers independently coded transcripts and met to iteratively refine the code and review transcripts for themes. Eighteen women were interviewed. Major themes that emerged were as follows: (a) Women's use of violence occurred within the context of their own victimization; (b) the arrest included a complex interplay between subject, partner, and police; (c) women perceived police arrest decisions to be based on a limited understanding of context; and (d) women experienced both positive and negative consequences of arrest. Many relationships did not fall under the traditional victim/perpetrator construct. Rather, women's use of violence evolved, influenced by prior experiences with violence. More appropriate methods must be developed for making arrest decisions, guiding justice system responses, and developing interventions for couples experiencing IPV. Recognition that women's use of partner violence often represented either a retaliatory or self-defensive gesture within the context of prior victimization suggests that victims' interventions should not only focus on empowerment but also provide skills and strategies to avoid temptation to adopt aggression as a primary method of self-protection. © The Author(s) 2014.

Real-Time Risk Prediction on the Wards: A Feasibility Study.

PubMed

Kang, Michael A; Churpek, Matthew M; Zadravecz, Frank J; Adhikari, Richa; Twu, Nicole M; Edelson, Dana P

2016-08-01

Failure to detect clinical deterioration in the hospital is common and associated with poor patient outcomes and increased healthcare costs. Our objective was to evaluate the feasibility and accuracy of real-time risk stratification using the electronic Cardiac Arrest Risk Triage score, an electronic health record-based early warning score. We conducted a prospective black-box validation study. Data were transmitted via HL7 feed in real time to an integration engine and database server wherein the scores were calculated and stored without visualization for clinical providers. The high-risk threshold was set a priori. Timing and sensitivity of electronic Cardiac Arrest Risk Triage score activation were compared with standard-of-care Rapid Response Team activation for patients who experienced a ward cardiac arrest or ICU transfer. Three general care wards at an academic medical center. A total of 3,889 adult inpatients. The system generated 5,925 segments during 5,751 admissions. The area under the receiver operating characteristic curve for electronic Cardiac Arrest Risk Triage score was 0.88 for cardiac arrest and 0.80 for ICU transfer, consistent with previously published derivation results. During the study period, eight of 10 patients with a cardiac arrest had high-risk electronic Cardiac Arrest Risk Triage scores, whereas the Rapid Response Team was activated on two of these patients (p < 0.05). Furthermore, electronic Cardiac Arrest Risk Triage score identified 52% (n = 201) of the ICU transfers compared with 34% (n = 129) by the current system (p < 0.001). Patients met the high-risk electronic Cardiac Arrest Risk Triage score threshold a median of 30 hours prior to cardiac arrest or ICU transfer versus 1.7 hours for standard Rapid Response Team activation. Electronic Cardiac Arrest Risk Triage score identified significantly more cardiac arrests and ICU transfers than standard Rapid Response Team activation and did so many hours in advance.

Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome.

PubMed

Meert, Kathleen L; Telford, Russell; Holubkov, Richard; Slomine, Beth S; Christensen, James R; Dean, J Michael; Moler, Frank W

2016-12-01

To investigate relationships between cardiac arrest characteristics and survival and neurobehavioral outcome among children recruited to the Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital trial. Secondary analysis of Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital trial data. Thirty-six PICUs in the United States and Canada. All children (n = 295) had chest compressions for greater than or equal to 2 minutes, were comatose, and required mechanical ventilation after return of circulation. Neurobehavioral function was assessed using the Vineland Adaptive Behavior Scales, Second Edition at baseline (reflecting prearrest status) and 12 months postarrest. U.S. norms for Vineland Adaptive Behavior Scales, Second Edition scores are 100 (mean) ± 15 (SD). Higher scores indicate better functioning. Outcomes included 12-month survival and 12-month survival with Vineland Adaptive Behavior Scales, Second Edition greater than or equal to 70. Cardiac etiology of arrest, initial arrest rhythm of ventricular fibrillation/tachycardia, shorter duration of chest compressions, compressions not required at hospital arrival, fewer epinephrine doses, and witnessed arrest were associated with greater 12-month survival and 12-month survival with Vineland Adaptive Behavior Scales, Second Edition greater than or equal to 70. Weekend arrest was associated with lower 12-month survival. Body habitus was associated with 12-month survival with Vineland Adaptive Behavior Scales, Second Edition greater than or equal to 70; underweight children had better outcomes, and obese children had worse outcomes. On multivariate analysis, acute life threatening event/sudden unexpected infant death, chest compressions more than 30 minutes, and weekend arrest were associated with lower 12-month survival; witnessed arrest was associated with greater 12-month survival. Acute life threatening event/sudden unexpected infant death, other respiratory causes of arrest except drowning, other/unknown causes of arrest, and compressions more than 30 minutes were associated with lower 12-month survival with Vineland Adaptive Behavior Scales, Second Edition greater than or equal to 70. Many factors are associated with survival and neurobehavioral outcome among children who are comatose and require mechanical ventilation after out-of-hospital cardiac arrest. These factors may be useful for identifying children at risk for poor outcomes, and for improving prevention and resuscitation strategies.

France's grandes écoles accused of elitism

NASA Astrophysics Data System (ADS)

Hellemans, Alexander

2010-02-01

Physicists in France have backed government plans to open up the country's elite grandes écoles to more students from poorer backgrounds. The government wants to allow up to 30% of students to be given free scholarships in an attempt to broaden the social mix of the student body. The physicists say this would not lead to a lowering of standards.

Using Conceptual Metaphor and Functional Grammar to Explore How Language Used in Physics Affects Student Learning

ERIC Educational Resources Information Center

Brookes, David T.; Etkina, Eugenia

2007-01-01

This paper introduces a theory about the role of language in learning physics. The theory is developed in the context of physics students and physicists talking and writing about the subject of quantum mechanics. We found that physicists' language encodes different varieties of analogical models through the use of grammar and conceptual metaphor.…

Students Know What Physicists Believe, but They Don't Agree: A Study Using the CLASS Survey

ERIC Educational Resources Information Center

Gray, Kara E.; Adams, Wendy K.; Wieman, Carl E.; Perkins, Katherine K.

2008-01-01

We measured what students perceive physicists to believe about physics and solving physics problems and how those perceptions differ from the students' personal beliefs. In this study, we used a modified version of the Colorado Learning Attitudes about Science Survey which asked students to respond to each statement with both their personal belief…

How the wave mechanics of Schrodinger was met in the USSR?

NASA Astrophysics Data System (ADS)

Vizgin, Vl. P.

1990-12-01

The author is giving an almost complete review of the era of quantum mechanics in the USSR during 20-th of XX-th century. The author is making accent on the vision of Soviet physicists visavi the new area of science. The most important European and Soviet physicists with major and notable contributions in quantum mechanics are cited.

A Superannuated Physicist's Attempts to Master Music Theory: Resolving Cognitive Conflicts and a Paradigm Clash

ERIC Educational Resources Information Center

Page-Shipp, Roy; van Niekerk, Caroline

2014-01-01

A sexagenarian retired physicist (the first author) set out, with the assistance of members of a university music department, to acquire some insight into Western music theory. For a lifelong singer and seasoned autodidact, this appeared to be a not too formidable challenge, yet he experienced significant difficulty in penetrating the music theory…

T$sup 2$WR (think, talk, write, and reason)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unruh, C.M.; Willis, C.A.

1972-01-01

From third Health Physics Society midyear topical symposium; Los Angeles, California, USA (29 Jan 1969). See CONF-690103P3. The health physicist, if he is to be effective in his profession, needs to develop his communication capabilities with craftsmen, management, and the public. His communications should meet the needs of and be understood by those receiving them. Second only to a thorough knowledge of the principles of health physics, persuasion is the health physicist' s biggest and best tool. By effective persuasion the health physicist should be able to accomplish his necessary work but he should always be ready to insist andmore » to stand firm to assure a safe course of action should his persuasive efforts prove to be ineffective. Public communications in the health physics field should be frequent. The organizational location of a health physics program in a corporate structure is optional. Good people will lead to a good program. In most situations an organizational position high in the corporate structure will help to assure proper importance and emphasis to the health physics program. In all cases clear lines of authority should be established and mutually understood by the health physicist, the craftsmen, and management. (auth)« less

Anniversary paper: evolution of ultrasound physics and the role of medical physicists and the AAPM and its journal in that evolution.

PubMed

Carson, Paul L; Fenster, Aaron

2009-02-01

Ultrasound has been the greatest imaging modality worldwide for many years by equipment purchase value and by number of machines and examinations. It is becoming increasingly the front end imaging modality; serving often as an extension of the physician's fingers. We believe that at the other extreme, high-end systems will continue to compete with all other imaging modalities in imaging departments to be the method of choice for various applications, particularly where safety and cost are paramount. Therapeutic ultrasound, in addition to the physiotherapy practiced for many decades, is just coming into its own as a major tool in the long progression to less invasive interventional treatment. The physics of medical ultrasound has evolved over many fronts throughout its history. For this reason, a topical review, rather than a primarily chronological one is presented. A brief review of medical ultrasound imaging and therapy is presented, with an emphasis on the contributions of medical physicists, the American Association of Physicists in Medicine (AAPM) and its publications, particularly its journal Medical Physics. The AAPM and Medical Physics have contributed substantially to training of physicists and engineers, medical practitioners, technologists, and the public.

The Importance of Science Policy and its Challenges

NASA Astrophysics Data System (ADS)

Preis, Benjamin

2015-03-01

I worked for physicist and Congressman Bill Foster (D-IL) as the Mather Public Policy Intern through the American Institute of Physics and the Society of Physics Students during the summer of 2014. This internship is meant to connect undergraduate physics students with the policy process in Washington DC. As a Mather Public Policy Intern, I worked for Congressman Foster researching policy initiatives such as science funding, STEM education, and environmental regulations. This talk will discuss my experience and many of the things that I learned as an undergraduate physicist working on Capitol Hill. For example, through my experience with the internship, I attended lectures and hearings that illuminated for me how members of Congress conceive of scientific research. I also met with many physicists on Capitol Hill working to improve government interest in physics research -- AAAS Fellows, Members of Congress, and Government Relations Specialists -- and I will talk about how I saw physicists impacting governmental policies relating to scientific research and development. This internship is part of the Society of Physics Students internship program and was funded by the John and Jane Mather Foundation for Science and the Arts. This work was part of the Society of Physics Students internship Program.

M. Hildred Blewett and the Blewett Scholarship

NASA Astrophysics Data System (ADS)

Whitten, Barbara

2011-03-01

M. Hildred Blewett became a physicist at a time when few women were physicists. After beginning her career at General Electric, she became a respected accelerator physicist, working at Brookhaven, Argonne, and eventually CERN. Blewett was married for a time to John Blewett, another accelerator physicist, but the couple divorced without children and she never remarried. She felt that her career in physics was hampered by her gender, and when she died in 2004 at the age of 93, she left the bulk of her estate to the American Physical Society, to found a Scholarship for women in physics. Since 2005 the Blewett Scholarship has been awarded to women in physics who are returning to physics after a career break, usually for family reasons. Family/career conflicts are one of the most important reasons why young women in early careers leave physics---a loss for them as well as the physics community, which has invested time and money in their training. The Blewett Scholarship is one way for the physics community, under the leadership of CSWP, to help these young women resume their careers. I will discuss the life and work of Hildred Blewett, the Blewett Scholarship, and its benefits to the physics community.

WE-H-201-03: Enthusiasm and Generosity of Spirit Necessitate a Volunteering Structure to Make Them More Meaningful

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pipman, Y.

The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved. This session will help to explain the specific ways that Medical Physicists can uniquely assistmore » in this grand effort to help bring radiotherapy to grossly-underserved areas. Not only can these experts fulfill an important purpose, they also can benefit professionally, academically, emotionally and socially from the endeavor. By assisting others worldwide with their skillset, Medical Physicists can end up helping themselves. Learning Objectives: Understand the need for radiotherapy in LMICs. Understand which agencies are seeking Medical Physicists for help in LMICs. Understand the potential research funding mechanisms are available to establish academic collaborations with LMIC researchers/physicians. Understand the potential social and emotional benefits for both the physicist and the LMIC partners when collaborations are made. Understand the potential for collaboration with other high-income scientists that can develop as the physicist partners with other large institutions to assist LMICs. Wil Ngwa - A recent United Nations Study reports that in developing countries more people have access to cell phones than toilets. In Africa, only 63% of the population has access to piped water, yet, 93% of Africans have cell phone service. Today, these cell phones, Skype, WhatsApp and other information and communication technologies (ICTs) connect us in unprecedented ways and are increasingly recognized as powerful, indispensable to global health. Thanks to ICTs, there are growing opportunities for Medical Physicists to reach out beyond the bunker and impact the world far beyond, without even having to travel. These growing opportunities in global health for Medical Physicists, powered by ICTs, will be highlighted in this presentation, illustrated by high impact examples/models across the globe that are improving patient safety and healthcare outcomes, saving lives. Learning Objectives: Published definitions of global health and the emerging field of global radiation oncology Learn about the transformative potential of ICTs in global radiation oncology care, research and education with focus on Medical Physics Learn about high impact examples of ICT-powered global radiation oncology and the increasing opportunities for participation by Medical Physicists. Yakov Pipman - The number and scope of volunteer Medical Physics activities in support of low-to-middle income countries has been increasing gradually. This happens through a variety of formal channels and to some extent through less formal but personal initiatives. A good deal of effort is dedicated by many, but many more could be recruited through a structured framework to volunteer. We will look into typical volunteer activities and how they fit with organizations already involved in advancing Medical Physics in LMIC. We will identify the range of these organizational activities and their scope to reveal areas of further need. We will point to a few key features of MPWB ( http://www.mpwb.org ) as a volunteering and collaborating structure and how members can get involved and contribute to these efforts at the grass roots level. The goal is that scarce resources can thus be channeled to complement rather than compete with those already in place. Learning Objectives: Understand the strengths and limitations of various organizations that support Medical Physics efforts in LMIC. Learn about ways to volunteer and contribute to Global Health through a grass roots organization focused on Medical Physics in LMIC. Perry Sprawls - With the growing capability and complexity of medical imaging methods in all countries of the world, the expanding role of medical physicists includes optimizing imaging procedures with respect to image quality, radiation dose, and other conflicting factors. With access to appropriate educational resources local medical physicists in all countries can provide direct clinical support and educational for other medical professionals. This is being supported through the process of Collaborative Teaching that combines the capabilities and experience of medical physicists in countries spanning the spectrum of economic, technological, and clinical development. The supporting resources are on the web at: http://www.sprawls.org/resources . Learning Objectives: Identify the medical physics educational needs to support effective and optimized medical imaging procedures. Use collaborative teaching resources to enhance the role of medical physicists in all countries of the world.« less

WE-H-201-01: The Opportunities and Benefits of Helping LMICs: How Helping Them Can Help You

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pollard, J.

The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved. This session will help to explain the specific ways that Medical Physicists can uniquely assistmore » in this grand effort to help bring radiotherapy to grossly-underserved areas. Not only can these experts fulfill an important purpose, they also can benefit professionally, academically, emotionally and socially from the endeavor. By assisting others worldwide with their skillset, Medical Physicists can end up helping themselves. Learning Objectives: Understand the need for radiotherapy in LMICs. Understand which agencies are seeking Medical Physicists for help in LMICs. Understand the potential research funding mechanisms are available to establish academic collaborations with LMIC researchers/physicians. Understand the potential social and emotional benefits for both the physicist and the LMIC partners when collaborations are made. Understand the potential for collaboration with other high-income scientists that can develop as the physicist partners with other large institutions to assist LMICs. Wil Ngwa - A recent United Nations Study reports that in developing countries more people have access to cell phones than toilets. In Africa, only 63% of the population has access to piped water, yet, 93% of Africans have cell phone service. Today, these cell phones, Skype, WhatsApp and other information and communication technologies (ICTs) connect us in unprecedented ways and are increasingly recognized as powerful, indispensable to global health. Thanks to ICTs, there are growing opportunities for Medical Physicists to reach out beyond the bunker and impact the world far beyond, without even having to travel. These growing opportunities in global health for Medical Physicists, powered by ICTs, will be highlighted in this presentation, illustrated by high impact examples/models across the globe that are improving patient safety and healthcare outcomes, saving lives. Learning Objectives: Published definitions of global health and the emerging field of global radiation oncology Learn about the transformative potential of ICTs in global radiation oncology care, research and education with focus on Medical Physics Learn about high impact examples of ICT-powered global radiation oncology and the increasing opportunities for participation by Medical Physicists. Yakov Pipman - The number and scope of volunteer Medical Physics activities in support of low-to-middle income countries has been increasing gradually. This happens through a variety of formal channels and to some extent through less formal but personal initiatives. A good deal of effort is dedicated by many, but many more could be recruited through a structured framework to volunteer. We will look into typical volunteer activities and how they fit with organizations already involved in advancing Medical Physics in LMIC. We will identify the range of these organizational activities and their scope to reveal areas of further need. We will point to a few key features of MPWB ( http://www.mpwb.org ) as a volunteering and collaborating structure and how members can get involved and contribute to these efforts at the grass roots level. The goal is that scarce resources can thus be channeled to complement rather than compete with those already in place. Learning Objectives: Understand the strengths and limitations of various organizations that support Medical Physics efforts in LMIC. Learn about ways to volunteer and contribute to Global Health through a grass roots organization focused on Medical Physics in LMIC. Perry Sprawls - With the growing capability and complexity of medical imaging methods in all countries of the world, the expanding role of medical physicists includes optimizing imaging procedures with respect to image quality, radiation dose, and other conflicting factors. With access to appropriate educational resources local medical physicists in all countries can provide direct clinical support and educational for other medical professionals. This is being supported through the process of Collaborative Teaching that combines the capabilities and experience of medical physicists in countries spanning the spectrum of economic, technological, and clinical development. The supporting resources are on the web at: http://www.sprawls.org/resources . Learning Objectives: Identify the medical physics educational needs to support effective and optimized medical imaging procedures. Use collaborative teaching resources to enhance the role of medical physicists in all countries of the world.« less

Age and benefit of early coronary angiography after out-of-hospital cardiac arrest in patients presenting with shockable rhythm: Insights from the Sudden Death Expertise Center registry.

PubMed

Aissaoui, Nadia; Bougouin, Wulfran; Dumas, Florence; Beganton, Franckie; Chocron, Richard; Varenne, Olivier; Spaulding, Christian; Karam, Nicole; Montalescot, Gilles; Aubry, Pierre; Sideris, Georges; Marijon, Eloi; Jouven, Xavier; Cariou, Alain

2018-07-01

Little is known about the association between provision of post-resuscitation care and prognosis of out-of-hospital cardiac arrest (OHCA) in elderly patients. Previous studies have suggested futility after 65 years of age. We aimed to evaluate the association of early coronary angiogram (CAG) followed if necessary by percutaneous coronary intervention (PCI), with favorable outcome after OHCA among elderly patients, compared to younger patients. Using a large French registry, we included all OHCA patients with an initial shockable rhythm, transported to hospital from 2011 to 2015. Favorable outcome was defined as hospital discharge with Cerebral Performance Category (CPC) 1 or 2. and were evaluated by multivariate logistic regression. Subgroup analyses were performed according to age groups: <65, 65-75 and >75 years. Among 1502 included patients, 31% were older than 65 and 12% older than 75 years. An early CAG was performed in 79%, 88% and 76% of patients below 65, between 65 and 75 and above 75, respectively (P = 0.002). The rate of patients discharged with CPC1 or 2 was 42% below 65, 38% between 65 and 75 and 24% above 75 (P < 0.001). Among the whole population, early CAG (OR = 6.4, 95% CI = 3.9-10.5, P < 0.001) was associated with favorable outcome. In subgroups analysis, CAG was associated with favorable outcome among patients <65 and 65-75. In patients >75, there was a trend towards a favorable outcome (OR2.9, 95CI = 0.9-9.1). In a large registry of OHCA survivors, the early CAG use was associated with a better prognosis. This benefit was persistent up to 75 years of age, suggesting that age alone should not guide the decision for early invasive strategy. Copyright © 2018 Elsevier B.V. All rights reserved.

14 CFR § 1203b.103 - Arrest authority.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Arrest authority. § 1203b.103 Section § 1203b.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SECURITY PROGRAMS; ARREST AUTHORITY AND USE OF FORCE BY NASA SECURITY FORCE PERSONNEL § 1203b.103 Arrest authority. (a) NASA security...

10 CFR 1049.6 - Exercise of arrest authority-Use of non-deadly force.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Exercise of arrest authority-Use of non-deadly force. 1049... OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.6 Exercise of arrest... for additional guidance on the use of non-deadly force in the exercise of arrest authority, as...

10 CFR 1049.6 - Exercise of arrest authority-Use of non-deadly force.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Exercise of arrest authority-Use of non-deadly force. 1049... OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.6 Exercise of arrest... for additional guidance on the use of non-deadly force in the exercise of arrest authority, as...

10 CFR 1049.7 - Exercise of arrest authority-Use of deadly force.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Exercise of arrest authority-Use of deadly force. 1049.7 Section 1049.7 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.7 Exercise of arrest authority...

10 CFR 1049.7 - Exercise of arrest authority-Use of deadly force.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Exercise of arrest authority-Use of deadly force. 1049.7 Section 1049.7 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.7 Exercise of arrest authority...

10 CFR 1049.6 - Exercise of arrest authority-Use of non-deadly force.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Exercise of arrest authority-Use of non-deadly force. 1049... OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.6 Exercise of arrest... for additional guidance on the use of non-deadly force in the exercise of arrest authority, as...

10 CFR 1049.7 - Exercise of arrest authority-Use of deadly force.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Exercise of arrest authority-Use of deadly force. 1049.7 Section 1049.7 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.7 Exercise of arrest authority...

10 CFR 1049.6 - Exercise of arrest authority-Use of non-deadly force.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Exercise of arrest authority-Use of non-deadly force. 1049... OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.6 Exercise of arrest... for additional guidance on the use of non-deadly force in the exercise of arrest authority, as...

10 CFR 1049.7 - Exercise of arrest authority-Use of deadly force.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Exercise of arrest authority-Use of deadly force. 1049.7 Section 1049.7 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.7 Exercise of arrest authority...

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

10 CFR 1047.6 - Use of physical force when making an arrest.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Use of physical force when making an arrest. 1047.6 Section 1047.6 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS General Provisions § 1047.6 Use of physical force when making an arrest...

10 CFR 1049.7 - Exercise of arrest authority-Use of deadly force.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Exercise of arrest authority-Use of deadly force. 1049.7 Section 1049.7 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) LIMITED ARREST AUTHORITY AND USE OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.7 Exercise of arrest authority...

10 CFR 1047.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... General Provisions § 1047.3 Definitions. (a) Act means section 161.k. of the Atomic Energy Act of 1954, as amended, (42 U.S.C. 2201.k.). (b) Arrest means any act, including taking, seizing or detaining of a person... of the person making the arrest. (c) Citizen's Arrest means that type of arrest which can be made by...

U.S. Juvenile Arrests: Gang Membership, Social Class, and Labeling Effects

ERIC Educational Resources Information Center

Tapia, Mike

2011-01-01

This study addresses the link between gang membership and arrest frequency, exploring the Gang x Socioeconomic status interaction on those arrests. Notoriously poor, delinquent, and often well-known to police, America's gang youth should have very high odds of arrest. Yet it is unclear whether mere membership in a gang increases the risk of arrest…

How Risky Is Marijuana Possession? Considering the Role of Age, Race, and Gender

ERIC Educational Resources Information Center

Nguyen, Holly; Reuter, Peter

2012-01-01

Arrest rates per capita for possession of marijuana have increased threefold over the last 20 years and now constitute the largest single arrest offense category. Despite the increase in arrest numbers, rates of use have remained stable during much of the same period. This article presents the first estimates of the arrest probabilities for…

The analysis on nonlinear control of the aircraft arresting system

NASA Astrophysics Data System (ADS)

Song, Jinchun; Du, Tianrong

2005-12-01

The aircraft arresting system is a complicated nonlinear system. This paper analyzes the mechanical-hydraulic structure of aircraft arresting system composed of electro hydraulic valve and establishes the dynamic equation of the aircraft arresting system. Based on the state-feedback linearization of nonlinear system, a PD-based controller is synthesized. Simulation studies indicate, while arresting the different type aircraft, the proposed controller has fast response, good tracking performance and strong robustness. By tuning the parameters of the PD controller, a satisfactory control performance can be guaranteed.

Deterring Rearrests for Drinking and Driving

PubMed Central

Eldred, Lindsey; McCutchan, Sabrina; Platt, Alyssa

2016-01-01

This study assesses why some individuals are re-arrested for driving while intoxicated (DWI). Using longitudinal data from North Carolina containing information on arrests and arrest outcomes, we test hypotheses that individuals prosecuted and convicted of DWI are less likely to be re-arrested for DWI. We allow for possible endogeneity of prosecution and conviction outcomes by using instrumental variables for the prosecutor’s prosecution rate and the judge’s conviction rate. With a three-year follow-up, the probability of DWI re-arrest was reduced by 6.6 percent if the person was prosecuted for DWI and, for those prosecuted, by 24.5 percent if convicted on this charge. Prosecution and conviction for DWI deters re-arrest for DWI. PMID:28626266

Girls InSpace project: A new space physics outreach initiative.

NASA Astrophysics Data System (ADS)

Abe Pacini, A.; Tegbaru, D.; Max, A., Sr.

2017-12-01

We present here the concept and state-of-art of the new space physics youth education and outreach initiative called "Girls InSpace project". The project goal is to spread quality scientific information to underrepresented groups, motivate girls in STEM and promote gender equality in the Space Physics area. Initially, the "Girls InSpace project" will be available in two languages (Portuguese and English) aiming to reach out to the youth of Brazil, United States, Nigeria, South Africa, Ethiopia and Angola. Eventually, the material will be translated to French and Spanish, focusing on French-speaking countries in Africa and Latin America. The project spans a collection of four books about a group of young girls and their adventures (always related to the sky and simultaneously introducing earth and space science concepts). Ancillary content such as a webpage, mobile applications and lesson plans are also in development. The books were written by a Space Physicist PhD woman, illustrated by a Brazilian young artist and commented by senior female scientists, creating positive role models for the next generation of girls in STEM. The story lines were drawn around the selected topics of astronomy and space physics, introducing scientific information to the target readers (girls from 8-13 years old) and enhancing their curiosity and critical thinking. The books instill the readers to explore the available extra web-content (with images, videos, interviews with scientists, real space data, coding and deeper scientific information) and game apps (with Virtual Reality components and real space images). Moreover, for teachers K-12, a collection of lesson plans will be made available, aiming to facilitate scientific content discussed in the books and inside classroom environments. Gender bias in STEM reported earlier this year in Nature and based on a study of the American Geophysical Union's member database showed a competitive disadvantage for women in the Earth and Space Sciences. The AGU has since challenged the scientific community to act and support gender balance initiatives as crucial path to progress. This project aligns well with AGU's mission and similar-thinking organizations, and aims to educate and promote development of young girls in underrepresented communities.

Women physicists in Russia: Problems and solutions at a time of fiscal crisis

NASA Astrophysics Data System (ADS)

Didenko, Nelli; Ermolaeva, Elena; Kunitsyna, Ekaterina; Kratasyuk, Valentina; Vitman, Renata

2013-03-01

Recently Russia has been affected by the global financial crisis, which has had both positive and negative effects on women physicists. The feminization of science and the stratification that characterize the Russian scientific community in general also affect the field of physics. This paper discusses the proportion of women in leadership and managerial positions in different areas of science and education and highlights the differences between women and men in their careers in physics and defense of their theses. Lomonosov Moscow State University is used to demonstrate the dynamics of gender in different academic positions. The professional activity of young women physicists is illustrated by their participation in all-Russian scientific forums, demonstrating their commitment to remain active in their careers despite the challenges of the current economic conditions.

Bradycardia as an early warning sign for cardiac arrest during routine laparoscopic surgery.

PubMed

Yong, Jonathan; Hibbert, Peter; Runciman, William B; Coventry, Brendon J

2015-12-01

The aim of this study was to identify clinical patterns of occurrence, management and outcomes surrounding cardiac arrest during laparoscopic surgery using the Australian Incident Monitoring Study (AIMS) database to guide possible prevention and treatment. The AIMS database includes incident reports from participating clinicians from secondary and tertiary healthcare centres across Australia and New Zealand. The AIMS database holds over 11 000 peri- and intraoperative incidents. The primary outcome was to characterize the pattern of events surrounding cardiac arrest. The secondary outcome was to identify successful management strategies in the possible prevention and treatment of cardiac arrest during laparoscopic surgery. Fourteen cases of cardiac arrest during laparoscopic surgery were identified. The majority of cases occurred in 'fit and healthy' patients during elective gynaecological and general surgical procedures. Twelve cases of cardiac arrest were directly associated with pneumoperitoneum with bradycardia preceding cardiac arrest in 75% of these. Management included deflation of pneumoperitoneum, atropine administration and cardiopulmonary resuscitation with circulatory restoration in all cases. The results imply vagal mechanisms associated with peritoneal distension as the predominant contributor to bradycardia and subsequent cardiac arrest during laparoscopy. Bradycardia during gas insufflation is not necessarily a benign event and appears to be a critical early warning sign for possible impending and unexpected cardiac arrest. Immediate deflation of pneumoperitoneum and atropine administration are effective measures that may alleviate bradycardia and possibly avert progression to cardiac arrest. © The Author 2015. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved.

A complex mechanism determines polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilis.

PubMed

Duggin, Iain G; Matthews, Jacqueline M; Dixon, Nicholas E; Wake, R Gerry; Mackay, Joel P

2005-04-01

Two dimers of the replication terminator protein (RTP) of Bacillus subtilis bind to a chromosomal DNA terminator site to effect polar replication fork arrest. Cooperative binding of the dimers to overlapping half-sites within the terminator is essential for arrest. It was suggested previously that polarity of fork arrest is the result of the RTP dimer at the blocking (proximal) side within the complex binding very tightly and the permissive-side RTP dimer binding relatively weakly. In order to investigate this "differential binding affinity" model, we have constructed a series of mutant terminators that contain half-sites of widely different RTP binding affinities in various combinations. Although there appeared to be a correlation between binding affinity at the proximal half-site and fork arrest efficiency in vivo for some terminators, several deviated significantly from this correlation. Some terminators exhibited greatly reduced binding cooperativity (and therefore have reduced affinity at each half-site) but were highly efficient in fork arrest, whereas one terminator had normal affinity over the proximal half-site, yet had low fork arrest efficiency. The results show clearly that there is no direct correlation between the RTP binding affinity (either within the full complex or at the proximal half-site within the full complex) and the efficiency of replication fork arrest in vivo. Thus, the differential binding affinity over the proximal and distal half-sites cannot be solely responsible for functional polarity of fork arrest. Furthermore, efficient fork arrest relies on features in addition to the tight binding of RTP to terminator DNA.

Long-term increase in coherence between the basal ganglia and motor cortex after asphyxial cardiac arrest and resuscitation in developing rats.

PubMed

Aravamuthan, Bhooma R; Shoykhet, Michael

2015-10-01

The basal ganglia are vulnerable to injury during cardiac arrest. Movement disorders are a common morbidity in survivors. Yet, neuronal motor network changes post-arrest remain poorly understood. We compared function of the motor network in adult rats that, during postnatal week 3, underwent 9.5 min of asphyxial cardiac arrest (n = 9) or sham intervention (n = 8). Six months after injury, we simultaneously recorded local field potentials (LFP) from the primary motor cortex (MCx) and single neuron firing and LFP from the rat entopeduncular nucleus (EPN), which corresponds to the primate globus pallidus pars interna. Data were analyzed for firing rates, power, and coherence between MCx and EPN spike and LFP activity. Cardiac arrest survivors display chronic motor deficits. EPN firing rate is lower in cardiac arrest survivors (19.5 ± 2.4 Hz) compared with controls (27.4 ± 2.7 Hz; P < 0.05). Cardiac arrest survivors also demonstrate greater coherence between EPN single neurons and MCx LFP (3-100 Hz; P < 0.001). This increased coherence indicates abnormal synchrony in the neuronal motor network after cardiac arrest. Increased motor network synchrony is thought to be antikinetic in primary movement disorders. Characterization of motor network synchrony after cardiac arrest may help guide management of post-hypoxic movement disorders.

Evaluation of related factors and the outcome in cardiac arrest resuscitation at Thammasat Emergency Department.

PubMed

Amnuaypattanapon, Kumpol; Udomsubpayakul, Umaporn

2010-12-01

In the present study, we aimed to define the factors contributing to patient survival after treatment by cardiopulmonary resuscitation (CPR) following cardiac arrest. Retrospective analysis was performed on cardiac arrest patients (n=138) who had CPR in the emergency department (ED) at Thammasat University hospital from 2007-2009. Logistic regression was used to analyze factors that related to the sustained return of spontaneous circulation (ROSC) for 20 minutes, survival until discharge, and survival up to 1 month post discharge. The sustained ROSC was 22.5%, survival to discharge 5.6%, and survival from discharge to 1 month 3.6%. Significant factors related to sustained ROSC was the location of cardiac arrest, the cause of arrest, shockable rhythm with defibrillation, the time until chest compression, and CPR duration. The factor influencing survival to discharge was chest compression performed within 15 minutes after cardiac arrest (p = 0.048). No factor however could be attributed to survivability up to 1 month following discharge. Our findings attribute six factors associated to ROSC including the location of arrest, the cause of cardiac arrest, initial cardiac rhythm, shockable rhythm with defibrillation, the time until chest compression and CPR duration. Statistically, resuscitation performed within 15 minutes of cardiac arrest increases the survivability of patients until discharge. However no factors could be related to the percentage of patients surviving up to 1 month post discharge.

76 FR 80966 - Agency Information Collection Activities; Proposed Collection: Age, Sex, and Race of Persons...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... Collection Activities; Proposed Collection: Age, Sex, and Race of Persons Arrested 18 Years of Age and Over; Age, Sex, and Race of Persons Arrested Under 18 Years of Age; Revision of a Currently Approved..., Sex, and Race of Persons Arrested 18 Years of Age and Over; Age, Sex, and Race of Persons Arrested...

10 CFR 1049.6 - Exercise of arrest authority-Use of non-deadly force.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Exercise of arrest authority-Use of non-deadly force. 1049... OF FORCE BY PROTECTIVE FORCE OFFICERS OF THE STRATEGIC PETROLEUM RESERVE § 1049.6 Exercise of arrest authority—Use of non-deadly force. (a) When a Protective Force Officer is authorized to make an arrest as...

Extracorporeal Membrane Oxygenation for Refractory Cardiac Arrest

PubMed Central

Conrad, Steven A; Rycus, Peter T

2017-01-01

Extracorporeal cardiopulmonary resuscitation (ECPR) is the use of rapid deployment venoarterial (VA) extracorporeal membrane oxygenation to support systemic circulation and vital organ perfusion in patients in refractory cardiac arrest not responding to conventional cardiopulmonary resuscitation (CPR). Although prospective controlled studies are lacking, observational studies suggest improved outcomes compared with conventional CPR when ECPR is instituted within 30–60 min following cardiac arrest. Adult and pediatric patients with witnessed in-hospital and out-of-hospital cardiac arrest and good quality CPR, failure of at least 15 min of conventional resuscitation, and a potentially reversible cause for arrest are candidates. Percutaneous cannulation where feasible is rapid and can be performed by nonsurgeons (emergency physicians, intensivists, cardiologists, and interventional radiologists). Modern extracorporeal systems are easy to prime and manage and are technically easy to manage with proper training and experience. ECPR can be deployed in the emergency department for out-of-hospital arrest or in various inpatient units for in-hospital arrest. ECPR should be considered for patients with refractory cardiac arrest in hospitals with an existing extracorporeal life support program, able to provide rapid deployment of support, and with resources to provide postresuscitation evaluation and management. PMID:28074817

Communication between members of the cardiac arrest team--a postal survey.

PubMed

Pittman, J; Turner, B; Gabbott, D A

2001-05-01

Effective communication enhances team building and is perceived to improve the quality of team performance. A recent publication from the Resuscitation Council (UK) has highlighted this fact and recommended that cardiac arrest team members make contact daily. We wished to identify how often members of this team communicate prior to a cardiopulmonary arrest. A questionnaire on cardiac arrest team composition, leadership, communication and debriefing was distributed nationally to Resuscitation Training Officers (RTOs) and their responses analysed. One hundred and thirty (55%) RTOs replied. Physicians and anaesthetists were the most prominent members of the team. The Medical Senior House Officer is usually nominated as the team leader. Eighty-seven centres (67%) have no communication between team members prior to attending a cardiopulmonary arrest. In 33%, communication occurs but is either informal or fortuitous. The RTOs felt that communication is important to enhance team dynamics and optimise task allocation. Only 7% achieve a formal debrief following a cardiac arrest. Communication between members of the cardiac arrest team before and after a cardiac arrest is poor. Training and development of these skills may improve performance and should be prioritised. Team leadership does not necessarily reflect experience or training.

FAST TRACK COMMUNICATION: A closer look at arrested spinodal decomposition in protein solutions

NASA Astrophysics Data System (ADS)

Gibaud, Thomas; Schurtenberger, Peter

2009-08-01

Concentrated aqueous solutions of the protein lysozyme undergo a liquid-solid transition upon a temperature quench into the unstable spinodal region below a characteristic arrest temperature of Tf = 15 °C. We use video microscopy and ultra-small angle light scattering in order to investigate the arrested structures as a function of initial concentration, quench temperature and rate of the temperature quench. We find that the solid-like samples show all the features of a bicontinuous network that is formed through an arrested spinodal decomposition process. We determine the correlation length ξ and demonstrate that ξ exhibits a temperature dependence that closely follows the critical scaling expected for density fluctuations during the early stages of spinodal decomposition. These findings are in agreement with an arrest scenario based on a state diagram where the arrest or gel line extends far into the unstable region below the spinodal line. Arrest then occurs when during the early stage of spinodal decomposition the volume fraction phi2 of the dense phase intersects the dynamical arrest threshold phi2,Glass, upon which phase separation gets pinned into a space-spanning gel network with a characteristic length ξ.

Arrested embryonic development: a review of strategies to delay hatching in egg-laying reptiles

PubMed Central

Rafferty, Anthony R.; Reina, Richard D.

2012-01-01

Arrested embryonic development involves the downregulation or cessation of active cell division and metabolic activity, and the capability of an animal to arrest embryonic development results in temporal plasticity of the duration of embryonic period. Arrested embryonic development is an important reproductive strategy for egg-laying animals that provide no parental care after oviposition. In this review, we discuss each type of embryonic developmental arrest used by oviparous reptiles. Environmental pressures that might have directed the evolution of arrest are addressed and we present previously undiscussed environmentally dependent physiological processes that may occur in the egg to bring about arrest. Areas for future research are proposed to clarify how ecology affects the phenotype of developing embryos. We hypothesize that oviparous reptilian mothers are capable of providing their embryos with a level of phenotypic adaptation to local environmental conditions by incorporating maternal factors into the internal environment of the egg that result in different levels of developmental sensitivity to environmental conditions after they are laid. PMID:22438503

Physicists and Physics in Munich

NASA Astrophysics Data System (ADS)

Teichmann, Jürgen; Eckert, Michael; Wolff, Stefan

We give a tour of Munich and some outlying sites that focuses on the lives and work of the most prominent physicists who lived in the city, Count Rumford, Joseph Fraunhofer, Georg Simon Ohm, Max Planck, Ludwig Boltzmann, Albert Einstein, Wilhelm Conrad Röntgen, Wilhelm Wien, Arnold Sommerfeld, Max von Laue, and Werner Heisenberg. We close with a self-guided tour that describes how to reach these sites in Munich.

Epistemic Views of the Relationship between Physics and Mathematics: Its Influence on the Approach of Undergraduate Students to Problem Solving

ERIC Educational Resources Information Center

Pereira de Ataide, Ana Raquel; Greca, Ileana Maria

2013-01-01

The relationship between physics and mathematics is hardly ever presented with sufficient clarity to satisfy either physicists or mathematicians. It is a situation that often leads to misunderstandings that may spread quickly from teacher to student, such as the idea that mathematics is a mere instrument for the physicist. In this paper, we…

The "Hard Problem" and the Quantum Physicists. Part 2: Modern Times

ERIC Educational Resources Information Center

Smith, C. U. M.

2009-01-01

This is the second part of a review of the work of quantum physicists on the "hard part" of the problem of mind. After an introduction which sets the scene and a brief review of contemporary work on the neural correlates of consciousness (NCC) the work of four prominent modern investigators is examined: J.C. Eccles/Friedrich Beck; Henry Stapp;…

Young physicists' forum

DOE Office of Scientific and Technical Information (OSTI.GOV)

T. Adams et al.

2001-11-02

The Young Physicists' Forum was an opportunity for the younger members of the particle-physics community to gather at Snowmass 2001 and to study and debate major issues that face the field over the next twenty years. Discussions were organized around three major topics: outreach and education, the impact of globalization, and building a robust and balanced field. We report on the results of these discussions, as presented on July 17, 2001.

A perspective on slow-relaxing molecular magnets built from rare-earths and nitronyl-nitroxide building blocks (invited)

NASA Astrophysics Data System (ADS)

Bogani, Lapo

2011-04-01

We offer a perspective, accessible to both chemists and physicists, of recent developments in the synthesis and characterization of molecular magnetic materials based on rare-earths and nitronyl-nitroxide radicals. We show both the rationale of the synthetic strategies and the observed behaviors. We highlight the relevance of these findings for synthetic chemists, material scientists, and physicists.

Weapons Storage Area Survey of Munitions Storage Igloos at Medina Annex, San Antonio, Texas

DTIC Science & Technology

2013-11-13

School of Aerospace Medicine Occupational and Environmental Health Department Consultative Services Division/OEC 2510 Fifth St. Wright-Patterson AFB...a. Purpose: The United States Air Force School of Aerospace Medicine, Occupational and Environmental Health Department, Radiation Health ...Attachment 3 with other pertinent regulatory issues. c. Survey Personnel: (1) Health Physicist, Air Force Safety Center (2) Health Physicist, USAFSAM

SU-A-210-04: Panel Discussion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stanford, J.

The purpose of this student annual meeting is to address topics that are becoming more relevant to medical physicists, but are not frequently addressed, especially for students and trainees just entering the field. The talk is divided into two parts: medical billing and regulations. Hsinshun Wu – Why should we learn radiation oncology billing? Many medical physicists do not like to be involved with medical billing or coding during their career. They believe billing is not their responsibility and sometimes they even refuse to participate in the billing process if given the chance. This presentation will talk about a physicist’smore » long career and share his own experience that knowing medical billing is not only important and necessary for every young medical physicist, but that good billing knowledge could provide a valuable contribution to his/her medical physics development. Learning Objectives: The audience will learn the basic definition of Current Procedural Terminology (CPT) codes performed in a Radiation Oncology Department. Understand the differences between hospital coding and physician-based or freestanding coding. Apply proper CPT coding for each Radiation Oncology procedure. Each procedure with its specific CPT code will be discussed in detail. The talk will focus on the process of care and use of actual workflow to understand each CPT code. Example coding of a typical Radiation Oncology procedure. Special procedure coding such as brachytherapy, proton therapy, radiosurgery, and SBRT. Maryann Abogunde – Medical physics opportunities at the Nuclear Regulatory Commission (NRC) The NRC’s responsibilities include the regulation of medical uses of byproduct (radioactive) materials and oversight of medical use end-users (licensees) through a combination of regulatory requirements, licensing, safety oversight including inspection and enforcement, operational experience evaluation, and regulatory support activities. This presentation will explore the career options for medical physicists in the NRC, how the NRC interacts with clinical medical physicists, and a physicist’s experience as a regulator. Learning Objectives: Explore non-clinical career pathways for medical physics students and trainees at the Nuclear Regulatory Commission. Overview of NRC medical applications and medical use regulations. Understand the skills needed for physicists as regulators. Abogunde is funded to attend the meeting by her employer, the NRC.« less

SU-A-210-03: Panel Discussion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodrigues, A.

The purpose of this student annual meeting is to address topics that are becoming more relevant to medical physicists, but are not frequently addressed, especially for students and trainees just entering the field. The talk is divided into two parts: medical billing and regulations. Hsinshun Wu – Why should we learn radiation oncology billing? Many medical physicists do not like to be involved with medical billing or coding during their career. They believe billing is not their responsibility and sometimes they even refuse to participate in the billing process if given the chance. This presentation will talk about a physicist’smore » long career and share his own experience that knowing medical billing is not only important and necessary for every young medical physicist, but that good billing knowledge could provide a valuable contribution to his/her medical physics development. Learning Objectives: The audience will learn the basic definition of Current Procedural Terminology (CPT) codes performed in a Radiation Oncology Department. Understand the differences between hospital coding and physician-based or freestanding coding. Apply proper CPT coding for each Radiation Oncology procedure. Each procedure with its specific CPT code will be discussed in detail. The talk will focus on the process of care and use of actual workflow to understand each CPT code. Example coding of a typical Radiation Oncology procedure. Special procedure coding such as brachytherapy, proton therapy, radiosurgery, and SBRT. Maryann Abogunde – Medical physics opportunities at the Nuclear Regulatory Commission (NRC) The NRC’s responsibilities include the regulation of medical uses of byproduct (radioactive) materials and oversight of medical use end-users (licensees) through a combination of regulatory requirements, licensing, safety oversight including inspection and enforcement, operational experience evaluation, and regulatory support activities. This presentation will explore the career options for medical physicists in the NRC, how the NRC interacts with clinical medical physicists, and a physicist’s experience as a regulator. Learning Objectives: Explore non-clinical career pathways for medical physics students and trainees at the Nuclear Regulatory Commission. Overview of NRC medical applications and medical use regulations. Understand the skills needed for physicists as regulators. Abogunde is funded to attend the meeting by her employer, the NRC.« less

Cardiac arrest

MedlinePlus

... it does not necessarily cause death. Sometimes a heart attack can trigger a cardiac arrest, however. Cardiac arrest is caused by a problem with the heart's electrical system, such as: Ventricular fibrillation (VF) . When ...

Flashback flame arrester devices for fuel cargo tank vapor vents

NASA Technical Reports Server (NTRS)

Bjorklund, R. A.; Kushida, R. O.

1981-01-01

The flame quenching capability of four types of flame arresting devices suitable for installation on fuel cargo tank vents of marine transport vessels is evaluated. A single 30 mesh screen, a dual 20 mesh screen, a spiral wound crimped metal ribbon, and a packed bed of ballast rings were tested. Flame speed and flame penetration of the test arresters were determined. Eight fuels representative of bulk cargoes were tested. The test arresters quenched a minimum of three flashback flames from all eight fuels, with one exception: high speed ethylene flames penetrated the dual 20 mesh screen on three tests. The arresters withstood the sustained flame from a propane/air mixture for 30 minutes. None of the arresters withstood the sustained flame from an ethylene/air mixture for more than 7 minutes.

Estimating cost-effectiveness of mass cardiopulmonary resuscitation training strategies to improve survival from cardiac arrest in private locations.

PubMed

Swor, Robert; Compton, Scott

2004-01-01

Most cardiopulmonary resuscitation (CPR) trainees are young, and most cardiac arrests occur in private residences witnessed by older individuals. To estimate the cost-effectiveness of a CPR training program targeted at citizens over the age of 50 years compared with that of current nontargeted public CPR training. A model was developed using cardiac arrest and known demographic data from a single suburban zip code (population 36,325) including: local data (1997-1999) regarding cardiac arrest locations (public vs. private); incremental survival with CPR (historical survival rate 7.8%, adjusted odds ratio for CPR 2.0); arrest bystander demographics obtained from bystander telephone interviews; zip code demographics regarding population age and distribution; and 12.50 dollars per student for the cost of CPR training. Published rates of CPR training programs by age were used to estimate the numbers typically trained. Several assumptions were made: 1) there would be one bystander per. arrest; 2) the bystander would always perform CPR if trained; 3) cardiac arrest would be evenly distributed in the population; and 4) CPR training for a proportion of the population would proportionally increase CPR provision. Rates of arrest, bystanders by age, number of CPR trainees needed to result in increased arrest survival, and training cost per life saved for a one-year study period were calculated. There were 24.3 cardiac arrests per year, with 21.9 (90%) occurring in homes. In 66.5% of the home arrests, the bystander was more than 50 years old. To yield one additional survivor using the current CPR training strategy, 12,306 people needed to be trained (3,510 bystanders aged < or = 50 years and 8,796 bystanders aged > 50 years), which resulted in CPR provision to 7.14 additional patients. The training cost per life saved for a bystander aged < or = 50 years was 313,214 dollars, and that for a bystander aged > 50 years was 785,040 dollars. Using a strategy of training only those < or = 50 years, 583 elders per cardiac arrest would need to be trained, with a cost of 53,383 dollars per life saved. Using these assumptions, current CPR training strategy is not a cost-effective intervention for home cardiac arrests. The high rate of elders witnessing CPR mandates focused CPR interventions for this population.

Biophysics at the Boundaries: The Next Problem Sets

NASA Astrophysics Data System (ADS)

Skolnick, Malcolm

2009-03-01

The interface between physics and biology is one of the fastest growing subfields of physics. As knowledge of such topics as cellular processes and complex ecological systems advances, researchers have found that progress in understanding these and other systems requires application of more quantitative approaches. Today, there is a growing demand for quantitative and computational skills in biological research and the commercialization of that research. The fragmented teaching of science in our universities still leaves biology outside the quantitative and mathematical culture that is the foundation of physics. This is particularly inopportune at a time when the needs for quantitative thinking about biological systems are exploding. More physicists should be encouraged to become active in research and development in the growing application fields of biophysics including molecular genetics, biomedical imaging, tissue generation and regeneration, drug development, prosthetics, neural and brain function, kinetics of nonequilibrium open biological systems, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems to name a few. In addition to moving into basic research in these areas, there is increasing opportunity for physicists in industry beginning with entrepreneurial roles in taking research results out of the laboratory and in the industries who perfect and market the inventions and developments that physicists produce. In this talk we will identify and discuss emerging opportunities for physicists in biophysical and biotechnological pursuits ranging from basic research through development of applications and commercialization of results. This will include discussion of the roles of physicists in non-traditional areas apart from academia such as patent law, financial analysis and regulatory science and the problem sets assigned in education and training that will enable future biophysicists to fill these roles.

Physicists and Economic Growth: Preparing the Next Generation

NASA Astrophysics Data System (ADS)

Arion, Douglas

2012-02-01

For many years it has been recognized that many physicists are ``hidden'' -- deep in the industrial world or holding positions not named ``physicist.'' In parallel with this phenomenon is the recognition that many new and innovative product ideas are, in fact, generated by physicists. There are many more ideas that could be brought to market to the benefit of both society and the inventor, but physicists don't often see themselves as the innovators and inventors that they actually are. A number of education programs have arisen to try to address this issue and to engender a greater entrepreneurial spirit in the scientific community. The ScienceWorks program at Carthage College was one of the first to do so, and has for nearly twenty years prepared undergraduate science majors to understand and practice innovation and value creation. Other programs, such as professional masters degrees, also serve to bridge the technical and business universes. As it is no doubt easier to teach a scientist the world of business than it is to teach a businessperson the world of physics, providing educational experiences in innovation and commercialization to physics students can have tremendous economic impact, and will also better prepare them for whatever career direction they may ultimately pursue, even if it is the traditional tenure-track university position. This talk will discuss education programs that have been effective at preparing physics students for the professional work environment, and some of the positive outcomes that have resulted. Also discussed will be the variety of opportunities and resources that exist for faculty and students to develop the skills, knowledge and abilities to recognize and successfully commercialize innovations.

Medical physics aspects of cancer care in the Asia Pacific region: 2011 survey results

PubMed Central

Kron, T; Azhari, HA; Voon, EO; Cheung, KY; Ravindran, P; Soejoko, D; Inamura, K; Han, Y; Ung, NM; Bold, L; Win, UM; Srivastava, R; Meyer, J; Farrukh, S; Rodriguez, L; Kuo, M; Lee, JCL; Kumara, A; Lee, CC; Krisanachinda, A; Nguyen, XC; Ng, KH

2012-01-01

Background: Medical physicists are essential members of the radiation oncology team. Given the increasing complexity of radiotherapy delivery, it is important to ensure adequate training and staffing. The aim of the present study was to update a similar survey from 2008 and assess the situation of medical physicists in the large and diverse Asia Pacific region. Methods: Between March and July 2011, a survey on profession and practice of radiation oncology medical physicists (ROMPs) in the Asia Pacific region was performed. The survey was sent to senior physicists in 22 countries. Replies were received from countries that collectively represent more than half of the world’s population. The survey questions explored five areas: education, staffing, work patterns including research and teaching, resources available, and job satisfaction. Results and discussion: Compared to a data from a similar survey conducted three years ago, the number of medical physicists in participating countries increased by 29% on average. This increase is similar to the increase in the number of linear accelerators, showing that previously identified staff shortages have yet to be substantially addressed. This is also highlighted by the fact that most ROMPs are expected to work overtime often and without adequate compensation. While job satisfaction has stayed similar compared to the previous survey, expectations for education and training have increased somewhat. This is in line with a trend towards certification of ROMPs. Conclusion: As organisations such as the International Labour Organization (ILO) start to recognise medical physics as a profession, it is evident that despite some encouraging signs there is still a lot of work required towards establishing an adequately trained and resourced medical physics workforce in the Asia Pacific region. PMID:22970066

Radiation risk perception and public information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boggs-Mayes, C.J.

1988-01-01

We as Health Physicists face what, at many times, appears to be a hopeless task. The task simply stated is informing the public about the risks (or lack thereof) of radiation. Unfortunately, the public has perceived radiation risks to be much greater than they actually are. An example of this problem is shown in a paper by Arthur C. Upton. Three groups of people -- the League of Women Voters, students, and Business and Professional Club members -- were asked to rank 30 sources of risk according to their contribution to the number of deaths in the United States. Notmore » surprisingly, they ranked nuclear power much higher and medical x-rays much lower than the actual values. In addition to the perception problem, we are faced with another hurdle: health physicists as communicators. Members of the Health Physics Society (HPS) found that the communication styles of most health physicists appear to be dissimilar to those of the general public. These authors administered the Myers-Briggs Type Indicator to the HPS Baltimore-Washington Chapter. This test, a standardized test for psychological type developed by Isabel Myers, ask questions that provide a quantitative measure of our natural preferences in four areas. Assume that you as a health physicist have the necessary skills to communicate information about radiation to the public. Health physicists do nothing with these tools. Most people involved in radiation protection do not get involved with public information activies. What I will attempt to do is heighten your interest in such activities. I will share information about public information activities in which I have been involved and give you suggestions for sources of information and materials. 2 refs., 1 tab.« less

In vivo Post-Cardiac Arrest Myocardial Dysfunction is Supported by CaMKII-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2

PubMed Central

Downey, Peter; Zalewski, Adrian; Rubio, Gabriel R.; Liu, Jing; Homburger, Julian R.; Grunwald, Zachary; Qi, Wei; Bollensdorff, Christian; Thanaporn, Porama; Ali, Ayyaz; Riemer, Kirk; Kohl, Peter; Mochly-Rosen, Daria; Gerstenfeld, Edward; Large, Stephen; Ali, Ziad; Ashley, Euan

2016-01-01

Background Survival after sudden cardiac arrest is limited by post-arrest myocardial dysfunction but understanding of this phenomenon is constrained by lack of data from a physiological model of disease. In this study, we established an in vivo model of cardiac arrest and resuscitation, characterized the biology of the associated myocardial dysfunction, and tested novel therapeutic strategies. Methods We developed rodent models of in vivo post-arrest myocardial dysfunction using extra-corporeal membrane oxygenation (ECMO) resuscitation followed by invasive hemodynamics measurement. In post-arrest isolated cardiomyocytes, we assessed mechanical load and Ca2+ induced Ca2+ release (CICR) simultaneously using the micro-carbon-fiber technique and observed reduced function and myofilament calcium sensitivity. We used a novel-designed fiber optic catheter imaging system, and a genetically encoded calcium sensor GCaMP6f, to image CICR in vivo. Results We found potentiation of CICR in isolated cells from this ECMO model and also in cells isolated from an ischemia-reperfusion Langendorff model perfused with oxygenated blood from an arrested animal, but not when reperfused in saline. We established that CICR potentiation begins in vivo. The augmented CICR observed post-arrest was mediated by the activation of Ca2+/calmodulin kinase II (CaMKII). Increased phosphorylation of CaMKII, phospholamban and ryanodine receptor 2 (RyR2) was detected in the post-arrest period. Exogenous adrenergic activation in vivo recapitulated Ca2+ potentiation but was associated with lesser CaMKII activation. Since oxidative stress and aldehydic adduct formation were high post arrest, we tested a small molecule activator of aldehyde dehydrogenase type 2, Alda-1, which reduced oxidative stress, restored calcium and CaMKII homeostasis, and improved cardiac function and post-arrest outcome in vivo. Conclusions Cardiac arrest and reperfusion lead to CaMKII activation and calcium long-term potentiation which support cardiomyocyte contractility in the face of impaired post-ischemic myofilament calcium sensitivity. Alda-1 mitigates these effects, normalizes calcium cycling and improves outcome. PMID:27582424

Which drugs are associated with highest risk for being arrested for driving under the influence? A case-control study.

PubMed

Bogstrand, Stig Tore; Gjerde, Hallvard

2014-07-01

The aim of this study was to determine the association between drug type and arrest for driving under the influence of drugs (DUID) by calculating odds ratios (ORs) using a case-control design. A DUID arrest is in most cases related to aberrant or risky driving and might therefore be regarded as a proxy for a drug related traffic crash. The 'cases' were 2738 drivers arrested on suspicion of drugged driving from April 2008 to March 2009 with blood alcohol concentrations below the legal limit of 0.2g/L; 794 were arrested due to involvement in road traffic crashes, whereas 1944 were arrested for other reasons, mainly dangerous driving, suspected impairment when stopped in traffic controls, or because of phone calls to the police from other road users or observers. The 'controls' were 9375 random drivers in normal traffic, also with alcohol concentrations below this limit. Blood samples from 'cases' and oral fluid samples from 'controls' were analyzed for 15 drugs that have legislative concentration limits in Norway, in addition to two other commonly detected psychoactive drugs. The most prevalent illicit drug in the control group was tetrahydrocannabinol (THC; 0.58%), which was also commonly found in samples from drivers arrested due to road crash (15.6%) or arrested for other reasons (21.8%). Amphetamine/methamphetamine was most prevalent among arrested drivers involved in crashes (30.6%) and drivers arrested for other reasons (56.9%), whereas only 0.18% of the control group was positive for amphetamine/methamphetamine. The single-use substances which gave highest OR for police arrest were amphetamine/methamphetamine, alprazolam, clonazepam and oxazepam. The majority of the alprazolam and clonazepam findings were probably due to non-therapeutic use of medicinal drugs purchased on the illegal market. Combinations of two or more drugs yielded higher ORs than the use of single substances; combinations of amphetamine/methamphetamine and benzodiazepines gave the highest risk. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Characterization of mitochondrial injury after cardiac arrest (COMICA).

PubMed

Donnino, Michael W; Liu, Xiaowen; Andersen, Lars W; Rittenberger, Jon C; Abella, Benjamin S; Gaieski, David F; Ornato, Joseph P; Gazmuri, Raúl J; Grossestreuer, Anne V; Cocchi, Michael N; Abbate, Antonio; Uber, Amy; Clore, John; Peberdy, Mary Anne; Callaway, Clifton W

2017-04-01

Mitochondrial injury post-cardiac arrest has been described in pre-clinical settings but the extent to which this injury occurs in humans remains largely unknown. We hypothesized that increased levels of mitochondrial biomarkers would be associated with mortality and neurological morbidity in post-cardiac arrest subjects. We performed a prospective multicenter study of post-cardiac arrest subjects. Inclusion criteria were comatose adults who suffered an out-of-hospital cardiac arrest. Mitochondrial biomarkers were measured at 0, 12, 24, 36 and 48h after return of spontaneous circulation as well as in healthy controls. Out of 111 subjects enrolled, 102 had evaluable samples at 0h. Cardiac arrest subjects had higher baseline cytochrome c levels compared to controls (2.18ng/mL [0.74, 7.74] vs. 0.16ng/mL [0.03, 0.91], p<0.001), and subjects who died had higher 0h cytochrome c levels compared to survivors (3.66ng/mL [1.40, 14.9] vs. 1.27ng/mL [0.16, 2.37], p<0.001). There were significantly higher Ribonuclease P (RNaseP) (3.3 [1.2, 5.7] vs. 1.2 [0.8, 1.2], p<0.001) and Beta-2microglobulin (B2M) (12.0 [1.0, 22.9], vs. 0.6 [0.6, 1.3], p<0.001) levels in cardiac arrest subjects at baseline compared to the control subjects. There were no differences between survivors and non-survivors for mitochondrial DNA, nuclear DNA, or cell free DNA. Cytochrome c was increased in post- cardiac arrest subjects compared to controls, and in post-cardiac arrest non-survivors compared to survivors. Nuclear DNA and cell free DNA was increased in plasma of post-cardiac arrest subjects. There were no differences in mitochondrial DNA, nuclear DNA, or cell free DNA between survivors and non-survivors. Mitochondrial injury markers showed mixed results in the post-cardiac arrest period. Future research needs to investigate these differences. Copyright © 2017 Elsevier B.V. All rights reserved.

Characterization of Mitochondrial Injury after Cardiac Arrest (COMICA)

PubMed Central

Donnino, Michael W.; Liu, Xiaowen; Andersen, Lars W.; Rittenberger, Jon C.; Abella, Benjamin S.; Gaieski, David F.; Ornato, Joseph P.; Gazmuri, Raúl J.; Grossestreur, Anne V.; Cocchi, Michaen N.; Abbate, Antonio; Uber, Amy; Clore, John; Peberdy, Mary Anne; Callaway, Clifton

2017-01-01

Introduction Mitochondrial injury post-cardiac arrest has been described in pre-clinical settings but the extent to which this injury occurs in humans remains largely unknown. We hypothesized that increased levels of mitochondrial biomarkers would be associated with mortality and neurological morbidity in post-cardiac arrest subjects. Methods We performed a prospective multicenter study of post-cardiac arrest subjects. Inclusion criteria were comatose adults who suffered an out-of-hospital cardiac arrest. Mitochondrial biomarkers were measured at 0, 12, 24, 36 and 48 hours after return of spontaneous circulation as well as in healthy controls. Results Out of 111 subjects enrolled, 102 had evaluable samples at 0 hours. Cardiac arrest subjects had higher baseline cytochrome c levels compared to controls (2.18 ng/mL [0.74, 7.74] vs. 0.16 ng/mL [0.03, 0.91], p<0.001), and subjects who died had higher 0 hours cytochrome c levels compared to survivors (3.66 ng/mL [1.40, 14.9] vs. 1.27 ng/mL [0.16, 2.37], p<0.001). There were significantly higher RNAase P (3.3 [1.2, 5.7] vs. 1.2 [0.8, 1.2], p<0.001) and B2M (12.0 [1.0, 22.9], vs. 0.6 [0.6, 1.3], p<0.001) levels in cardiac arrest subjects at baseline compared to the control subjects. There were no differences between survivors and non-survivors for mitochondrial DNA, nuclear DNA, or cell free DNA. Conclusions Cytochrome C was increased in post-cardiac arrest subjects compared to controls, and in post-cardiac arrest non-survivors compared to survivors. Nuclear DNA and cell free DNA was increased in plasma of post-cardiac arrest subjects. There were no differences in mitochondrial DNA, nuclear DNA, or cell free DNA between survivors and non-survivors. Mitochondrial injury markers showed mixed results in post-arrest period. Future research needs to investigate these differences. PMID:28126408

Oocyte transport: Developmental competence of bovine oocytes arrested at germinal vesicle stage by cycloheximide under air.

PubMed

Hashimoto, Shu; Kimura, Kouji; Iwata, Hisataka; Takakura, Ryo

2003-02-01

The effects of the medium (TCM 199 or SOFaa) and temperature (20 or 39 C) during meiotic arrest by cycloheximide (CHX) under air on the developmental competence of bovine oocytes after in vitro maturation (IVM) and fertilization (IVF) were investigated. Oocytes were maintained in meiotic arrest by 10 microg/ml CHX in a 50-microl droplet of 25-mM HEPES-buffered TCM 199 (H199) at 39 C or synthetic oviduct fluid (HSOFaa) at 20 or 39 C in air for 24 h. After release from the arrest, the oocytes was matured and fertilized in vitro and their developmental competence was examined. The developmental rate of oocytes arrested in HSOFaa at 20 C to the blastocyst stage was similar to that of non-arrested oocytes but was significantly higher (P<0.05) than that of oocytes arrested at 39 C in H199 or in HSOFaa. In consideration of oocyte transport conditions, we also investigated the meiotic arrest of oocytes maintained in a 0.25-ml straw by CHX individually with 10 microl HSOFaa or as a group (40-50 oocytes) with 170-200 microl HSOFaa at 20 C in air for 24 h. After release from meiotic arrest, the developmental competence of these oocytes was assessed similarly. The developmental rate of oocytes treated with CHX individually was similar to that of those treated with CHX in 50-microl droplet of HSOFaa at 20 C. However, the developmental rate of oocytes treated with CHX as a group was lower than that of oocytes treated with CHX in a 50-microl droplet. Five blastocysts developed from oocytes maintained in meiotic arrest in a plastic straw were transferred to five recipient heifers. Consequently, three recipients became pregnant and 2 calves were delivered. The results of the present study indicate that bovine oocytes treated with CHX in HSOFaa at 20 C under air retain the same developmental competence as non-arrested oocytes.

Use of Lung Allografts from Brain-Dead Donors after Cardiopulmonary Arrest and Resuscitation

PubMed Central

Worni, Mathias; Osho, Asishana A.; Snyder, Laurie D.; Palmer, Scott M.; Pietrobon, Ricardo; Davis, R. Duane; Hartwig, Matthew G.

2013-01-01

Rationale: Patients who progress to brain death after resuscitation from cardiac arrest have been hypothesized to represent an underused source of potential organ donors; however, there is a paucity of data regarding the viability of lung allografts after a period of cardiac arrest in the donor. Objectives: To analyze postoperative complications and survival after lung transplant from brain-dead donors resuscitated after cardiac arrest. Methods: The United Network for Organ Sharing database records donors with cardiac arrest occurring after brain death. Adult recipients of lung allografts from these arrest/resuscitation donors between 2005 and 2011 were compared with nonarrest donors. Propensity score matching was used to reduce the effect of confounding. Postoperative complications and overall survival were assessed using McNemar’s test for correlated binary proportions and Kaplan–Meier methods. Measurements and Main Results: A total of 479 lung transplant recipients from arrest/resuscitation donors were 1:1 propensity matched from a cohort of 9,076 control subjects. Baseline characteristics in the 1:1-matched cohort were balanced. There was no significant difference in perioperative mortality, airway dehiscence, dialysis requirement, postoperative length of stay (P ≥ 0.38 for all), or overall survival (P = 0.52). A subanalysis of the donor arrest group demonstrated similar survival when stratified by resuscitation time quartile (P = 0.38). Conclusions: There is no evidence of inferior outcomes after lung transplant from brain-dead donors who have had a period of cardiac arrest provided that good lung function is preserved and the donor is otherwise deemed acceptable for transplantation. Potential expansion of the donor pool to include cardiac arrest as the cause of brain death requires further study. PMID:23777361

Perioperative cardiac arrest: an evolutionary analysis of the intra-operative cardiac arrest incidence in tertiary centers in Brazil.

PubMed

Vane, Matheus Fachini; do Prado Nuzzi, Rafael Ximenes; Aranha, Gustavo Fabio; da Luz, Vinicius Fernando; Sá Malbouisson, Luiz Marcelo; Gonzalez, Maria Margarita Castro; Auler, José Otávio Costa; Carmona, Maria José Carvalho

2016-01-01

Great changes in medicine have taken place over the last 25 years worldwide. These changes in technologies, patient risks, patient profile, and laws regulating the medicine have impacted the incidence of cardiac arrest. It has been postulated that the incidence of intraoperative cardiac arrest has decreased over the years, especially in developed countries. The authors hypothesized that, as in the rest of the world, the incidence of intraoperative cardiac arrest is decreasing in Brazil, a developing country. The aim of this study was to search the literature to evaluate the publications that relate the incidence of intraoperative cardiac arrest in Brazil and analyze the trend in the incidence of intraoperative cardiac arrest. There were 4 articles that met our inclusion criteria, resulting in 204,072 patients undergoing regional or general anesthesia in two tertiary and academic hospitals, totalizing 627 cases of intraoperative cardiac arrest. The mean intraoperative cardiac arrest incidence for the 25 years period was 30.72:10,000 anesthesias. There was a decrease from 39:10,000 anesthesias to 13:10,000 anesthesias in the analyzed period, with the related lethality from 48.3% to 30.8%. Also, the main causes of anesthesia-related cause of mortality changed from machine malfunction and drug overdose to hypovolemia and respiratory causes. There was a clear reduction in the incidence of intraoperative cardiac arrest in the last 25 years in Brazil. This reduction is seen worldwide and might be a result of multiple factors, including new laws regulating the medicine in Brazil, incorporation of technologies, better human development level of the country, and better patient care. Copyright © 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

Association between a Hospital’s Quality Performance for In-Hospital Cardiac Arrest and Common Medical Conditions

PubMed Central

Chen, Lena M.; Nallamothu, Brahmajee K.; Krumholz, Harlan M.; Spertus, John A.; Tang, Fengming; Chan, Paul S.

2015-01-01

Background Public reporting on hospital quality has been widely adopted for common medical conditions. Adding a measure of inpatient survival after cardiac arrest is being considered. It is unknown if this measure would be redundant, given evidence that hospital organization and culture can have hospital-wide effects on quality. Therefore, we sought to evaluate the correlation between inpatient survival after cardiac arrest and 30-day risk-standardized mortality rates for common medical conditions. Methods and Results Using data between 2007 and 2010 from a national in-hospital cardiac arrest registry, we calculated risk-standardized in-hospital survival rates for cardiac arrest at each hospital. We obtained risk-standardized 30-day mortality rates for acute myocardial infarction (AMI), heart failure (HF), and pneumonia from Hospital Compare for the same period. The relationship between a hospital’s performance on cardiac arrest and these other medical conditions was assessed using weighted Pearson correlation coefficients. Among 26,270 patients with in-hospital cardiac arrest at 130 hospitals, survival rates varied across hospitals, with a median risk-standardized hospital survival rate of 22.1% and an inter-quartile range (IQR) of 19.7% to 24.2%. There were no significant correlations between a hospital’s outcomes for its cardiac arrest patients and its patients admitted for AMI (correlation of −0.12; P=0.16), HF (correlation of −0.05; P=0.57), or pneumonia (correlation of −0.15, P=0.10). Conclusions Hospitals that performed better on publicly reported outcomes for three common medical conditions did not necessarily have better cardiac arrest survival rates. Public reporting on cardiac arrest outcomes could provide new information about hospital quality. PMID:24221831

Prognostic value of adrenal gland volume after cardiac arrest: Association of CT-scan evaluation with shock and mortality.

PubMed

Mongardon, Nicolas; Savary, Guillaume; Geri, Guillaume; El Bejjani, Marie-Rose; Silvera, Stéphane; Dumas, Florence; Charpentier, Julien; Pène, Frédéric; Mira, Jean-Paul; Cariou, Alain

2018-05-28

Adrenal gland volume is associated with survival in septic shock. As sepsis and post-cardiac arrest syndrome share many pathophysiological features, we assessed the association between adrenal gland volume measured by computerized tomography (CT)-scan and post-cardiac arrest shock and intensive care unit (ICU) mortality, in a large cohort of out-of-hospital cardiac arrest (OHCA) patients. We also investigated the association between adrenal hormonal function and both adrenal gland volume and outcomes. Prospective analysis of CT-scan performed at hospital admission in patients admitted after OHCA (2007-2012). A pair of blinded radiologist calculated manually adrenal gland volume. In a subgroup of patients, plasma cortisol was measured at admission and 60 min after a cosyntropin test. Factors associated with post-cardiac arrest shock and ICU mortality were identified using multivariate logistic regression. Among 775 patients admitted during this period after OHCA, 138 patients were included: 72 patients (52.2%) developed a post-cardiac arrest shock, and 98 patients (71.1%) died. In univariate analysis, adrenal gland volume was not different between patients with and without post-cardiac arrest shock: 10.6 and 11.3 cm 3 , respectively (p = 0.9) and between patients discharged alive or dead: 10.2 and 11.8 cm 3 , respectively (p = 0.4). Multivariate analysis confirmed that total adrenal gland volume was associated neither with post-cardiac arrest shock nor mortality. Neither baseline cortisol level nor delta between baseline and after cosyntropin test cortisol levels were associated with adrenal volume, post-cardiac arrest shock onset or mortality. After OHCA, adrenal gland volume is not associated with post-cardiac arrest shock onset or ICU mortality. Adrenal gland volume does not predict adrenal gland hormonal response. Copyright © 2018 Elsevier B.V. All rights reserved.

Self-Reported Arrests Among Indigenous Adolescents: a Longitudinal Analysis of Community, Family, and Individual Risk Factors

PubMed Central

Gentzler, Kari C.

2018-01-01

Purpose North American indigenous (American Indian/Canadian First Nations) adolescents are overrepresented in the juvenile justice systems in the USA and Canada. One explanation advanced for disproportionate numbers of racial and ethnic minorities in the justice systems is the unequal distribution of risk factors across groups. The purpose of this study is to investigate the prevalence of and risk factors for first arrest within a population sample of indigenous adolescents. Methods The data come from an 8-year longitudinal panel study of indigenous youth (n = 641) from the northern Midwest and Canada, spanning ages 10 to 19 years. We used a discrete-time survival model to estimate the overall hazard of first arrest and change in the arrest hazard over time and included both time-invariant and time varying risk factors. Results The risk of arrest increased over time, although the largest increase occurred between waves 3 and 4, when the adolescents averaged 13.1 and 14.3 years, respectively. The youth had a 55 % probability of being arrested at least once by the end of the study. Of the time-invariant risk factors, exposure to violence, parent arrest, age, and income were associated with overall risk of first arrest. Three time-varying risk factors (alcohol use, marijuana use, and peer delinquency) were associated with changes in the risk of first arrest. Conclusions Being arrested carries significant repercussions for young people, including involvement in the juvenile justice system as well as consequences into adulthood. Communities must go beyond programs that target problem behaviors because community, family, and peer factors are also important. PMID:29503797

Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.

PubMed

Mori, Hiroyuki; Sakashita, Sohei; Ito, Jun; Ishii, Eiji; Akiyama, Yoshinori

2018-02-23

VemP ( V ibrio protein e xport m onitoring p olypeptide) is a secretory protein comprising 159 amino acid residues, which functions as a secretion monitor in Vibrio and regulates expression of the downstream V.secDF2 genes. When VemP export is compromised, its translation specifically undergoes elongation arrest at the position where the Gln 156 codon of vemP encounters the P-site in the translating ribosome, resulting in up-regulation of V.SecDF2 production. Although our previous study suggests that many residues in a highly conserved C-terminal 20-residue region of VemP contribute to its elongation arrest, the exact role of each residue remains unclear. Here, we constructed a reporter system to easily and exactly monitor the in vivo arrest efficiency of VemP. Using this reporter system, we systematically performed a mutational analysis of the 20 residues (His 138 -Phe 157 ) to identify and characterize the arrest motif. Our results show that 15 residues in the conserved region participate in elongation arrest and that multiple interactions between important residues in VemP and in the interior of the exit tunnel contribute to the elongation arrest of VemP. The arrangement of these important residues induced by specific secondary structures in the ribosomal tunnel is critical for the arrest. Pro scanning analysis of the preceding segment (Met 120 -Phe 137 ) revealed a minor role of this region in the arrest. Considering these results, we conclude that the arrest motif in VemP is mainly composed of the highly conserved multiple residues in the C-terminal region. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

Inhibition of the Mitochondrial Fission Protein Drp1 Improves Survival in a Murine Cardiac Arrest Model

PubMed Central

Sharp, Willard W.; Beiser, David G.; Fang, Yong Hu; Han, Mei; Piao, Lin; Varughese, Justin; Archer, Stephen L.

2015-01-01

Objectives Survival following sudden cardiac arrest is poor despite advances in cardiopulmonary resuscitation (CPR) and the use of therapeutic hypothermia. Dynamin related protein 1 (Drp1), a regulator of mitochondrial fission, is an important determinant of reactive oxygen species generation, myocardial necrosis, and left ventricular function following ischemia/reperfusion injury, but its role in cardiac arrest is unknown. We hypothesized that Drp1 inhibition would improve survival, cardiac hemodynamics, and mitochondrial function in an in vivo model of cardiac arrest. Design Laboratory investigation. Setting University laboratory Interventions Anesthetized and ventilated adult female C57BL/6 wild-type mice underwent an 8-min KCl induced cardiac arrest followed by 90 seconds of CPR. Mice were then blindly randomized to a single intravenous injection of Mdivi-1 (0.24 mg/kg), a small molecule Drp1 inhibitor or vehicle (DMSO). Measurements and Main Results Following resuscitation from cardiac arrest, mitochondrial fission was evidenced by Drp1 translocation to the mitochondrial membrane and a decrease in mitochondrial size. Mitochondrial fission was associated with increased lactate and evidence of oxidative damage. Mdivi-1 administration during CPR inhibited Drp1 activation, preserved mitochondrial morphology, and decreased oxidative damage. Mdivi-1 also reduced the time to return of spontaneous circulation (ROSC) 116±4 vs. 143±7 sec (p<. 001) during CPR and enhanced myocardial performance post-ROSC. These improvements were associated with significant increases in survival (65% vs. 33%) and improved neurological scores up to 72 hours post cardiac arrest. Conclusions Post cardiac arrest inhibition of Drp1 improves time to ROSC and myocardial hemodynamics resulting in improved survival and neurological outcomes in a murine model of cardiac arrest. Pharmacological targeting of mitochondrial fission may be a promising therapy for cardiac arrest. PMID:25599491

WE-D-16A-01: ACR Radiology Leadership Institute

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rubin, G

The Radiology Leadership Institute (RLI) was established in 2011 by the American College of Radiology with a mission to prepare leaders who will shape the future of radiology to ensure quality, elevate service and deliver extraordinary patient care. Leadership skills are critical to medical physicists in order for them to assure that imaging and therapy are safe and of the highest quality possible. This session will provide an introduction to the RLI and its programs with an emphasis on how medical physicists can get involved and what they might expect to gain through their engagement with the RLI. The sessionmore » will also provide a framework for leadership in healthcare with an emphasis on roles and opportunities for medical physicists to enhance their effectiveness as members of the healthcare, medical education, and research communities.« less

Ask not what physics can do for biology--ask what biology can do for physics.

PubMed

Frauenfelder, Hans

2014-10-08

Stan Ulam, the famous mathematician, said once to Hans Frauenfelder: 'Ask not what Physics can do for biology, ask what biology can do for physics'. The interaction between biologists and physicists is a two-way street. Biology reveals the secrets of complex systems, physics provides the physical tools and the theoretical concepts to understand the complexity. The perspective gives a personal view of the path to some of the physical concepts that are relevant for biology and physics (Frauenfelder et al 1999 Rev. Mod. Phys. 71 S419-S442). Schrödinger's book (Schrödinger 1944 What is Life? (Cambridge: Cambridge University Press)), loved by physicists and hated by eminent biologists (Dronamraju 1999 Genetics 153 1071-6), still shows how a great physicist looked at biology well before the first protein structure was known.

The Role of Physicists in Anti-Terrorism: Transportation

NASA Astrophysics Data System (ADS)

Fainberg, Anthony

2002-04-01

Physicists, along with many other categories of scientists, participate in efforts against terrorism in a multitude of ways, including developing explosive detectors, sensors, security procedures, technical analyses, and decision tools. Transportation, especially civil aviation, is a field of focus within the anti- and counterterrorism arenas. The most spectacular terrorist acts have generally aimed at this sector and this trend is likely to continue. Physicists play their roles in all sectors: government, private industry, and even academia. Defense against terrorism has become a national priority in the United States, and one may expect the roles of scientific experts to become more important. The tactics of terrorists will change and develop, so it will become necessary to develop ever more sophisticated measures to fight them. Technology is part of the answer, but human factors, vulnerability analyses, threat assessment, and security procedures are equally important.

About Cardiac Arrest

MedlinePlus

... Options for Heart Failure Living With HF and Advanced HF High Blood Pressure ... Updated:Mar 10,2017 What is cardiac arrest? Cardiac arrest is the abrupt loss of heart function in a person who may or may not ...

Incidence and outcome of in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit.

PubMed

Nolan, Jerry P; Soar, Jasmeet; Smith, Gary B; Gwinnutt, Carl; Parrott, Francesca; Power, Sarah; Harrison, David A; Nixon, Edel; Rowan, Kathryn

2014-08-01

To report the incidence, characteristics and outcome of adult in-hospital cardiac arrest in the United Kingdom (UK) National Cardiac Arrest Audit database. A prospectively defined analysis of the UK National Cardiac Arrest Audit (NCAA) database. 144 acute hospitals contributed data relating to 22,628 patients aged 16 years or over receiving chest compressions and/or defibrillation and attended by a hospital-based resuscitation team in response to a 2222 call. The main outcome measures were incidence of adult in-hospital cardiac arrest and survival to hospital discharge. The overall incidence of adult in-hospital cardiac arrest was 1.6 per 1000 hospital admissions with a median across hospitals of 1.5 (interquartile range 1.2-2.2). Incidence varied seasonally, peaking in winter. Overall unadjusted survival to hospital discharge was 18.4%. The presenting rhythm was shockable (ventricular fibrillation or pulseless ventricular tachycardia) in 16.9% and non-shockable (asystole or pulseless electrical activity) in 72.3%; rates of survival to hospital discharge associated with these rhythms were 49.0% and 10.5%, respectively, but varied substantially across hospitals. These first results from the NCAA database describing the current incidence and outcome of adult in-hospital cardiac arrest in UK hospitals will serve as a benchmark from which to assess the future impact of changes in service delivery, organisation and treatment for in-hospital cardiac arrest. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Criminal justice involvement, trauma, and negative affect in Iraq and Afghanistan war era veterans.

PubMed

Elbogen, Eric B; Johnson, Sally C; Newton, Virginia M; Straits-Troster, Kristy; Vasterling, Jennifer J; Wagner, H Ryan; Beckham, Jean C

2012-12-01

Although criminal behavior in veterans has been cited as a growing problem, little is known about why some veterans are at increased risk for arrest. Theories of criminal behavior postulate that people who have been exposed to stressful environments or traumatic events and who report negative affect such as anger and irritability are at increased risk of antisocial conduct. We hypothesized veterans with posttraumatic stress disorder (PTSD) or traumatic brain injury (TBI) who report anger/irritability would show higher rates of criminal arrests. To test this, we examined data in a national survey of N = 1,388 Iraq and Afghanistan war era veterans. We found that 9% of respondents reported arrests since returning home from military service. Most arrests were associated with nonviolent criminal behavior resulting in incarceration for less than 2 weeks. Unadjusted bivariate analyses revealed that veterans with probable PTSD or TBI who reported anger/irritability were more likely to be arrested than were other veterans. In multivariate analyses, arrests were found to be significantly related to younger age, male gender, having witnessed family violence, prior history of arrest, alcohol/drug misuse, and PTSD with high anger/irritability but were not significantly related to combat exposure or TBI. Findings show that a subset of veterans with PTSD and negative affect may be at increased risk of criminal arrest. Because arrests were more strongly linked to substance abuse and criminal history, clinicians should also consider non-PTSD factors when evaluating and treating veterans with criminal justice involvement.

Criminal Justice Involvement, Trauma, and Negative Affect in Iraq and Afghanistan War Era Veterans

PubMed Central

Elbogen, Eric B.; Johnson, Sally C.; Newton, Virginia M.; Straits-Troster, Kristy; Vasterling, Jennifer J.; Wagner, H. Ryan; Beckham, Jean C.

2012-01-01

Although criminal behavior in veterans has been cited as a growing problem, little is known about why some veterans are at increased risk for arrest. Theories of criminal behavior postulate that people who have been exposed to stressful environments or traumatic events and who report negative affect such as anger and irritability are at increased risk of antisocial conduct. We thus hypothesized that veterans with posttraumatic stress disorder (PTSD) or traumatic brain injury (TBI) who report anger/irritability would show higher rates of criminal arrests. To test this, we examined data in a national survey of N=1388 Iraq and Afghanistan War Era Veterans. We found that 9% of respondents reported arrests since returning home from military service. Most arrests were associated with nonviolent criminal behavior resulting in incarceration for less than two weeks. Unadjusted bivariate analyses revealed that veterans with probable PTSD or TBI who reported anger/irritability were most likely to be arrested. In multivariate analyses, arrests were found to be significantly related to younger age, male gender, having witnessed family violence, prior history of arrest, alcohol/drug misuse, and PTSD with high anger/irritability but were not significantly related to combat exposure or TBI. Findings show that a subset of veterans with PTSD and negative affect may be at increased risk of criminal arrest. Since arrests are more strongly linked to substance abuse and criminal history, clinicians should also consider non-PTSD factors when evaluating and treating veterans with criminal justice involvement. PMID:23025247

In-hospital pediatric cardiac arrest in Spain.

PubMed

López-Herce, Jesús; del Castillo, Jimena; Cañadas, Sonia; Rodríguez-Núñez, Antonio; Carrillo, Angel

2014-03-01

The objective was to analyze the characteristics and prognostic factors of in-hospital pediatric cardiac arrest in Spain. A prospective observational study was performed to examine in-hospital pediatric cardiac arrest. Two hundred children were studied, aged between 1 month and 18 years, with in-hospital cardiac arrest. Univariate and multivariate logistic regression analyses were performed to assess the influence of each factor on survival to hospital discharge. Return of spontaneous circulation was achieved in 74% of the patients and 41% survived to hospital discharge. The survival rate was significantly higher than that reported in a previous Spanish study 10 years earlier (25.9%). In the univariate analysis, the factors related to mortality were body weight higher than 10 kg; continuous infusion of vasoactive drugs prior to cardiac arrest; sepsis and neurological disorders as causes of cardiac arrest, the need for treatment with adrenaline, bicarbonate, and volume expansion, and prolonged cardiopulmonary resuscitation. In the multivariate analysis, the factors related to mortality were hematologic/oncologic diseases, continuous infusion of vasoactive drugs prior to cardiac arrest, cardiopulmonary resuscitation for more than 20 min, and treatment with bicarbonate and volume expansion. Survival after in-hospital cardiac arrest in children has significantly improved in recent years. The factors related to in-hospital mortality were hematologic/oncologic diseases, continuous infusion of vasoactive drugs prior to cardiac arrest, the duration of cardiopulmonary resuscitation, and treatment with bicarbonate and volume expansion. Copyright © 2013 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

Involvement of Mos-MEK-MAPK pathway in cytostatic factor (CSF) arrest in eggs of the parthenogenetic insect, Athalia rosae.

PubMed

Yamamoto, Daisuke S; Tachibana, Kazunori; Sumitani, Megumi; Lee, Jae Min; Hatakeyama, Masatsugu

2008-01-01

Extensive survey of meiotic metaphase II arrest during oocyte maturation in vertebrates revealed that the mitogen-activated protein kinase (MAPK) pathway regulated by the c-mos proto-oncogene product, Mos, has an essential role in cytostatic activity, termed cytostatic factor (CSF). In contrast, little is known in invertebrates in which meiotic arrest occurs in most cases at metaphase I (MI arrest). A parthenogenetic insect, the sawfly Athalia rosae, in which artificial egg activation is practicable, has advantages to investigate the mechanisms of MI arrest. Both the MAPK/extracellular signal-regulated protein kinase kinase (MEK) and MAPK were phosphorylated and maintained active in MI-arrested sawfly eggs, whereas they were dephosphorylated soon after egg activation. Treatment of MI-arrested eggs with U0126, an inhibitor of MEK, resulted in dephosphorylation of MAPK and MI arrest was resumed. The sawfly c-mos gene orthologue encoding a serine/threonine kinase was cloned and analyzed. It was expressed in nurse cells in the ovaries. To examine CSF activity of the sawfly Mos, synthesized glutathione S-transferase (GST)-fusion sawfly Mos protein was injected into MI-resumed eggs in which MEK and MAPK were dephosphorylated. Both MEK and MAPK were phosphorylated again upon injection. In these GST-fusion sawfly Mos-injected eggs subsequent mitotic (syncytial) divisions were blocked and embryonic development was ceased. These results demonstrated that the MEK-MAPK pathway was involved in maintaining CSF arrest in sawfly eggs and Mos functioned as its upstream regulatory molecule.

Off the Beat. An Appreciation of Werner Heisenberg and Some Talk About How Physics Was in the Good Old Days

ERIC Educational Resources Information Center

Thomsen, Dietrick E.

1976-01-01

Presented is an insight into man's idea about physics and being a physicist in the days when Heisenberg, P. A. M. Dirac, Louis de Broglic and other famous physicists were young men. Heisenberg is compared to Newton, inventing new math as he needed it. Emphasis is placed on the fact that he was not a Nazi sympathizer. (EB)

Kristian Camilleri: Heisenberg and the Interpretation of Quantum Mechanics—The Physicist as Philosopher. Cambridge University Press, 2009, ISBN-13:9780521884846, 211 pp.

NASA Astrophysics Data System (ADS)

Kleemans, Machiel

2010-11-01

The book Heisenberg and the Interpretation of Quantum Mechanics—The Physicist as Philosopher, by Kristian Camilleri is critically reviewed. The work details Heisenberg’s philosophical development from an early positivist commitment towards a later philosophy of language. It is of interest to researchers and graduate students in the history and philosophy of quantum mechanics.

The Bohr paradox

NASA Astrophysics Data System (ADS)

Crease, Robert P.

2008-05-01

In his book Niels Bohr's Times, the physicist Abraham Pais captures a paradox in his subject's legacy by quoting three conflicting assessments. Pais cites Max Born, of the first generation of quantum physics, and Werner Heisenberg, of the second, as saying that Bohr had a greater influence on physics and physicists than any other scientist. Yet Pais also reports a distinguished younger colleague asking with puzzlement and scepticism "What did Bohr really do?".

Intuitive Space Weather Displays to Improve Space Situational Awareness (SSA)

DTIC Science & Technology

2011-09-01

parsimonious offering. After engaging several mathematicians and space physicists to devise valid computational formulas for aggregating the four hazard... PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Aptima, Inc.,12 Gill Street Ste 200,Woburn,MA... physicists , the operational users find little use in receiving particle fluxes or magnetometer readings collected by the scientific community. Fortunately

Dmitry Ivanenko-a superstar of Soviet Physics

NASA Astrophysics Data System (ADS)

Sardanashvily, Gennady

A detailed biography and bibliography (about 300 articles and a number of books available in Libraries) of professor Dmitry Dmitryevich Ivanenko (Iwanenko) (1904-1994) has beeen given by one of his disciples. The book includes also references of some widely known physicists about one of the lieding theoretical physicists of the Physics Department of the Moscow State University. Some documents from the personal archive of Ivanenko(Iwanenko) are included in the book.

Physicist falls foul of US export law

NASA Astrophysics Data System (ADS)

Gwynne, Peter

2008-10-01

A retired US plasma physicist is seeking to overturn his conviction last month of offences under the American Arms Export Control Act, which prohibits the export, without a government licence, of technology and data to foreign nationals or nations. A jury in Knoxville, Tennessee, found JReece Roth, 70, guilty of illegally exporting technical information about a military project to develop plasma technology for guiding spyplanes that operate as weapons or surveillance devices.

Post-modern physics, bathtub style

NASA Astrophysics Data System (ADS)

Robinson, Andrew

2008-01-01

We recently renovated our bathroom. One of the things that my wife - also a physicist - and I both agreed on was the absolute necessity for a large bathtub in which to stretch out, read a book and think. I find that most of my best ideas occur to me in the bath, and apparently I am not alone - the distinguished nuclear physicist Leo Szilárd is also reputed to have used bathtub meditation.

The Status of Women Physicists in Pakistan

NASA Astrophysics Data System (ADS)

Hasnain, Aziz Fatima; Islam, Jabeen

2009-04-01

A significant number of women physicists work in high-ranking positions in the universities and research institutes of Pakistan; however, the number of women is much lower compared with men. We surveyed these women about the challenges they faced in the workplace and the pace of their progress and scientific work in a male-dominant society. We also surveyed girls' attitudes toward studying physics at the graduate and undergraduate levels.

DNA synthesis arrest sites at the right terminus of rat long interspersed repeated (LINE or L1Rn) DNA family members.

PubMed Central

d'Ambrosio, E; Furano, A V

1987-01-01

An approximately equal to 150-bp GC-rich (approximately equal to 60%) region is at the right end of rat long interspersed repeated DNA (LINE or L1Rn) family members. We report here that one of the DNA strands from this region contains several non-palindromic sites that strongly arrest DNA synthesis in vitro by the prokaryotic Klenow and T4 DNA polymerases, the eukaryotic alpha polymerase, and AMV reverse transcriptase. The strongest arrest sites are G-rich (approximately equal to 70%) homopurine stretches of 18 or more residues. Shorter homopurine stretches (12 residues or fewer) did not arrest DNA synthesis even if the stretch contains 11/12 G residues. Arrest of the prokaryotic polymerases was not affected by their respective single strand binding proteins or polymerase accessory proteins. The region of duplex DNA which contains DNA synthesis arrest sites reacts with bromoacetaldehyde when present in negatively supercoiled molecules. By contrast, homopurine stretches that do not arrest DNA synthesis do not react with bromoacetaldehyde. The presence of bromoacetaldehyde-reactive bases in a G-rich homopurine-containing duplex under torsional stress is thought to be caused by base stacking in the homopurine strand. Therefore, we suggest that base-stacked regions of the template arrest DNA synthesis. Images PMID:2436148

Clinical and Electroencephalographic Correlates in Pediatric Cardiac Arrest: Experience at a Tertiary Care Center.

PubMed

Brooks, Garrett A; Park, Jun T

2018-06-01

Pediatric cardiac arrest is a significant cause of death and neurologic disability; however, there is a paucity of literature specifically evaluating the utility of prognostic factors in the pediatric population. This retrospective chart review examines clinical, laboratory, and electroencephalographic (EEG) data in children following cardiopulmonary arrest to better characterize findings that may inform prognosis. Pre-arrest clinical characteristics, resuscitation details, and post-arrest hospital course variables were analyzed and neurologic outcome was determined using the Pediatric Cerebral Performance Category scale. Forty-one patients were identified who had cardiac arrest from March, 2011 to January, 2015. Duration of cardiopulmonary resuscitation ( p  = 0.013), out-of-hospital arrest ( p  = 0.005), arterial pH (0.014), arterial lactate (0.004), lack of pupil reactivity to light ( p  < 0.001), absent motor response to noxious stimuli ( p  < 0.001), and absent brainstem reflexes ( p  < 0.001) were all predictors of poor neurologic outcome. EEG background suppression ( p  = 0.005) was associated with poor outcome. Nine patients had electrographically recorded seizures, which began up to 1 week following cardiac arrest. Two patients (4.9%) experienced post-anoxic myoclonic status epilepticus and both had a poor outcome. Georg Thieme Verlag KG Stuttgart · New York.

A longitudinal examination of offending and specialization among a sample of Massachusetts domestic violence offenders.

PubMed

Richards, Tara N; Jennings, Wesley G; Tomsich, Elizabeth A; Gover, Angela R

2013-02-01

A paucity of existing research focuses on longitudinal examinations of criminal trajectories among reoffenses committed by domestic violence offenders. Specifically, few studies have longitudinally assessed whether domestic violence offenders specialize, recidivating in domestic violence assault, or generalize, committing a range of personal and property crimes. Acknowledging these research deficiencies, the current study uses longitudinal data from a cohort of 317 batterers who were processed in a domestic violence court to investigate the trajectories of domestic violence arrests and nondomestic violence arrests over a 10-year period. The degree of overlap between domestic and nondomestic violence arrest trajectory groups is examined through a cross-tabulation and chi-square analysis. Logistic and multinomial regression models are applied to identify risk factors that distinguish trajectory groups. A PROC TRAJ procedure identifies two trajectory groups for domestic violence arrests (low and high rate) and three trajectory groups for nondomestic violence arrests (very low, low, and high rate). Results indicate that specialization among domestic violence offenders is rare-prior alcohol and drug crimes predict membership in the high-rate domestic violence arrest trajectory group and prior domestic violence arrests predict membership in both the low-rate and high-rate nondomestic violence arrest trajectories. Implications for future research and policy are discussed in this article.

Chromosomal Aneuploidies and Early Embryonic Developmental Arrest.

PubMed

Maurer, Maria; Ebner, Thomas; Puchner, Manuela; Mayer, Richard Bernhard; Shebl, Omar; Oppelt, Peter; Duba, Hans-Christoph

2015-01-01

Selecting the best embryo for transfer, with the highest chance of achieving a vital pregnancy, is a major goal in current in vitro fertilization (IVF) technology. The high rate of embryonic developmental arrest during IVF treatment is one of the limitations in achieving this goal. Chromosomal abnormalities are possibly linked with chromosomal arrest and selection against abnormal fertilization products. The objective of this study was to evaluate the frequency and type of chromosomal abnormalities in preimplantation embryos with developmental arrest. This cohort study included blastomeres of embryos with early developmental arrest that were biopsied and analyzed by fluorescence in-situ hybridization (FISH) with probes for chromosomes 13, 16, 18, 21 and 22. Forty-five couples undergoing IVF treatment were included, and 119 arrested embryos were biopsied. All probes were obtained from the Kinderwunsch Zentrum, Linz, Austria, between August 2009 and August 2011. Of these embryos, 31.6% were normal for all chromosomes tested, and 68.4% were abnormal. Eleven embryos were uniformly aneuploid, 20 were polyploid, 3 were haploid, 11 displayed mosaicism and 22 embryos exhibited chaotic chromosomal complement. Nearly 70% of arrested embryos exhibit chromosomal errors, making chromosomal abnormalities a major cause of embryonic arrest and may be a further explanation for the high developmental failure rates during culture of the embryos in the IVF setting.

Pre-resuscitation factors associated with mortality in 49,130 cases of in-hospital cardiac arrest: a report from the National Registry for Cardiopulmonary Resuscitation.

PubMed

Larkin, Gregory Luke; Copes, Wayne S; Nathanson, Brian H; Kaye, William

2010-03-01

To evaluate key pre-arrest factors and their collective ability to predict post-cardiopulmonary arrest mortality. CPR is often initiated indiscriminately after in-hospital cardiopulmonary arrest. Improved understanding of pre-arrest factors associated with mortality may inform advance care planning. A cohort of 49,130 adults who experienced pulseless cardiopulmonary arrest from January 2000 to September 2004 was obtained from 366 US hospitals participating in the National Registry for Cardiopulmonary Resuscitation (NRCPR). Logistic regression with bootstrapping was used to model in-hospital mortality, which included those discharged in unfavorable and severely worsened neurologic state (Cerebral Performance Category >/=3). Overall in-hospital mortality was 84.1%. Advanced age, black race, non-cardiac, non-surgical illness category, pre-existing malignancy, acute stroke, trauma, septicemia, hepatic insufficiency, general floor or Emergency Department location, and pre-arrest use of vasopressors or assisted/mechanical ventilation were independently predictive of in-hospital mortality. Retained peri-arrest factors including cardiac monitoring, and shockable initial pulseless rhythms, were strongly associated with survival. The validation model's AUROC curve (0.77) revealed fair performance. Predictive pre-resuscitation factors may supplement patient-specific information available at bedside to assist in revising resuscitation plans during the patient's hospitalization. Copyright 2009. Published by Elsevier Ireland Ltd.

A proposed protocol for acceptance and constancy control of computed tomography systems: a Nordic Association for Clinical Physics (NACP) work group report.

PubMed

Kuttner, Samuel; Bujila, Robert; Kortesniemi, Mika; Andersson, Henrik; Kull, Love; Østerås, Bjørn Helge; Thygesen, Jesper; Tarp, Ivanka Sojat

2013-03-01

Quality assurance (QA) of computed tomography (CT) systems is one of the routine tasks for medical physicists in the Nordic countries. However, standardized QA protocols do not yet exist and the QA methods, as well as the applied tolerance levels, vary in scope and extent at different hospitals. To propose a standardized protocol for acceptance and constancy testing of CT scanners in the Nordic Region. Following a Nordic Association for Clinical Physics (NACP) initiative, a group of medical physicists, with representatives from four Nordic countries, was formed. Based on international literature and practical experience within the group, a comprehensive standardized test protocol was developed. The proposed protocol includes tests related to the mechanical functionality, X-ray tube, detector, and image quality for CT scanners. For each test, recommendations regarding the purpose, equipment needed, an outline of the test method, the measured parameter, tolerance levels, and the testing frequency are stated. In addition, a number of optional tests are briefly discussed that may provide further information about the CT system. Based on international references and medical physicists' practical experiences, a comprehensive QA protocol for CT systems is proposed, including both acceptance and constancy tests. The protocol may serve as a reference for medical physicists in the Nordic countries.

TH-A-16A-01: Image Quality for the Radiation Oncology Physicist: Review of the Fundamentals and Implementation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seibert, J; Imbergamo, P

The expansion and integration of diagnostic imaging technologies such as On Board Imaging (OBI) and Cone Beam Computed Tomography (CBCT) into radiation oncology has required radiation oncology physicists to be responsible for and become familiar with assessing image quality. Unfortunately many radiation oncology physicists have had little or no training or experience in measuring and assessing image quality. Many physicists have turned to automated QA analysis software without having a fundamental understanding of image quality measures. This session will review the basic image quality measures of imaging technologies used in the radiation oncology clinic, such as low contrast resolution, highmore » contrast resolution, uniformity, noise, and contrast scale, and how to measure and assess them in a meaningful way. Additionally a discussion of the implementation of an image quality assurance program in compliance with Task Group recommendations will be presented along with the advantages and disadvantages of automated analysis methods. Learning Objectives: Review and understanding of the fundamentals of image quality. Review and understanding of the basic image quality measures of imaging modalities used in the radiation oncology clinic. Understand how to implement an image quality assurance program and to assess basic image quality measures in a meaningful way.« less

[An alchemist or swindler? The case of Zbigniew Dunikowski].

PubMed

Łotysz, Sławomir

2009-01-01

In early 1930s the newspapers and street journals in Europe and the United States were frequently reporting on a case of Zbigniew Dunikowski, a Polish engineer, who claimed to be in possession of a secret formula allowing production of gold from ordinary sand and rocks. He believed that most of those materials contain some particles of gold. For the precious metal however, it takes millions of years to precipitate into the ledges that could be mined. His method was based on a conviction, that the process can be accelerated. Although he was nicknamed "Polish alchemist" very soon, his vain promises attracted attention of financiers and even some European political leaders. After few years of futile experiments, he was sued by his impatient financial backers, and arrested. While in detention, he was allowed to make the last attempt to produce gold and regain his repute and freedom. When this attempt failed, the judge sentenced him for two years in prison and ordered him to repay some 3 million francs ($100,000) to his investors. He was also fined with ... 100 francs fine (some 4 dollars). It can not be definitively stated, whether Dunikowski was truly convicted that his formula for making gold could have been working or he acted as a swindler from the very beginning. He exclaimed that the accusation of fraud was caused by bankers, who would never let his method to undermine the status quo of world's economy. The experiments conducted in Ecole Centrale in Paris during his trial, were assisted buy several eminent French scientist. But although the judge sentenced, that Dunikowki's "secret process for turning sand into gold is an impracticable combination of absurdities and contradictions," Polish engineer was still able to find other backers after being released from French prison. We find the traces of his further activity in Italy, Switzerland, Belgium and Philippines. Finally, in early 1950s he ended his journey in the United States as a political refugee.

Sudden Cardiac Arrest (SCA) Risk Assessment

MedlinePlus

... HRS Find a Specialist Share Twitter Facebook SCA Risk Assessment Sudden Cardiac Arrest (SCA) occurs abruptly and without ... people of all ages and health conditions. Start Risk Assessment The Sudden Cardiac Arrest (SCA) Risk Assessment Tool ...

Effects of Maternal Work Incentives on Teen Drug Arrests

PubMed Central

Corman, Hope; Dave, Dhaval; Kalil, Ariel; Reichman, Nancy E.

2017-01-01

Purpose This study exploits differences in the implementation of welfare reform across states and over time in the United States in the attempt to identify causal effects of welfare reform on youth arrests for drug-related crimes between 1990 and 2005, the period during which welfare reform unfolded. Methodology Using monthly arrest data from the U.S. Federal Bureau of Investigation's Uniform Crime Reports, we estimate the effects of welfare reform implementation on drug-related arrests among 15–17 year olds in the United States between 1990 and 2005. We use a difference-in-differences (DD) approach that exploits the implementation of welfare reform across states and over time to estimate effects for teens exposed to welfare reform. Findings The findings, based on numerous different model specifications, suggest that welfare reform had no statistically significant effect on teen drug arrests. Most estimates were positive and suggestive of a small (3%) increase in arrests. Originality/Value This study investigated the effects of a broad-based policy change that altered maternal employment, family income, and other family characteristics on youth drug arrests. PMID:28989228

Cell cycle arrest in the jewel wasp Nasonia vitripennis in larval diapause.

PubMed

Shimizu, Yuta; Mukai, Ayumu; Goto, Shin G

2018-04-01

Insects enter diapause to synchronise their life cycle with biotic and abiotic environmental conditions favourable for their development, reproduction, and survival. One of the most noticeable characteristics of diapause is the blockage of ontogeny. Although this blockage should occur with the cessation of cellular proliferation, i.e. cell cycle arrest, it was confirmed only in a few insect species and information on the molecular pathways involved in cell cycle arrest is limited. In the present study, we investigated developmental and cell cycle arrest in diapause larvae of the jewel wasp Nasonia vitripennis. Developmental and cell cycle arrest occur in the early fourth instar larval stage of N. vitripennis under short days. By entering diapause, the S fraction of the cell cycle disappears and approximately 80% and 20% of cells arrest their cell cycle in the G0/G1 and G2 phases, respectively. We further investigated expression of cell cycle regulatory genes and some housekeeping genes to dissect molecular mechanisms underlying the cell cycle arrest. Copyright © 2016 Elsevier Ltd. All rights reserved.

Gender as a moderator in predicting re-arrest among treated drug-involved offenders.

PubMed

Yang, Yang; Knight, Kevin; Joe, George W; Rowan, Grace A; Lehman, Wayne E K; Flynn, Patrick M

2015-02-01

The primary aim of the current study is to explore gender differences on the relationships of pre-treatment risk factors and psychosocial functioning with time to re-arrest following termination from prison. The sample consisted of 384 males and 313 females who were admitted to four prison-based substance abuse treatment programs. Results showed that female inmates experienced a longer time to re-arrest than male inmates. Higher self-reported ratings of decision making confidence and peer support were associated with a lower likelihood of re-arrest for males. Males with higher self-esteem ratings were more likely to be re-arrested than males who reported lower self-esteem. Females with more self-reported criminal involvement had a higher rate of re-arrest than did those with less criminal involvement. In contrast to males, females with relatively high self-reported self-esteem had a lower rate of re-arrest than their counterparts who reported low self-esteem. Clinical implications include the importance of enhancing decision-making confidence and peer support for males and self-esteem for females. Copyright © 2015 Elsevier Inc. All rights reserved.

A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I – Protection via specific pathways)

PubMed Central

2014-01-01

Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological deficits are limited. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following cardiac arrest with associated global cerebral ischemia. The search was limited to investigational therapies that were utilized to treat global cerebral ischemia associated with cardiac arrest. In this review we discuss potential mechanisms of neurologic protection following cardiac arrest including actions of several medical gases such as xenon, argon, and nitric oxide. The 3 included mechanisms are: 1. Modulation of neuronal cell death; 2. Alteration of oxygen free radicals; and 3. Improving cerebral hemodynamics. Only a few approaches have been evaluated in limited fashion in cardiac arrest patients and results show inconclusive neuroprotective effects. Future research focusing on combined neuroprotective strategies that target multiple pathways are compelling in the setting of global brain ischemia resulting from cardiac arrest. PMID:24808942

From door to recovery: a collaborative approach to the development of a post-cardiac arrest center.

PubMed

Williams, Donna; Calder, Shelley; Cocchi, Michael N; Donnino, Michael W

2013-10-01

Out-of-hospital cardiac arrest remains common and, despite advances in resuscitation practices, continues to carry a high mortality that may be influenced by several factors, including where a patient is cared for after the cardiac arrest. Implementing a post-cardiac arrest care guideline for survivors of out-of-hospital and in-hospital cardiac arrest involves a multidisciplinary approach with short-term and long-term strategies. Physician and nursing leaders must work in synergy to guide the implementation of an evidence-based plan of care. A collaborative approach was used at a hospital to develop processes, build consensus for protocols, and provide support to staff and teams. A joint approach has allowed the hospital to move from traditional silos of individual departmental care to a continuum of patient-focused management after cardiac arrest. This care coordination is initiated in the emergency department and follows the patient through to discharge.

Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells.

PubMed

Ly, Tony; Endo, Aki; Lamond, Angus I

2015-01-02

Previously, we analyzed protein abundance changes across a 'minimally perturbed' cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014). In this study, we compare data from elutriated cells with NB4 cells arrested at comparable phases using serum starvation, hydroxyurea, or RO-3306. While elutriated and arrested cells have similar patterns of DNA content and cyclin expression, a large fraction of the proteome changes detected in arrested cells are found to reflect arrest-specific responses (i.e., starvation, DNA damage, CDK1 inhibition), rather than physiological cell cycle regulation. For example, we show most cells arrested in G2 by CDK1 inhibition express abnormally high levels of replication and origin licensing factors and are likely poised for genome re-replication. The protein data are available in the Encyclopedia of Proteome Dynamics (

Mental health court outcomes: a comparison of re-arrest and re-arrest severity between mental health court and traditional court participants.

PubMed

Moore, Marlee E; Hiday, Virginia Aldigé

2006-12-01

Mental health courts have been proliferating across the country since their establishment in the late 1990's. Although numerous advocates have proclaimed their merit, only few empirical studies have evaluated their outcomes. This paper evaluates the effect of one mental health court on criminal justice outcomes by examining arrests and offense severity from one year before to one year after entry into the court, and by comparing mental health court participants to comparable traditional criminal court defendants on these measures. Multivariate models support the prediction that mental health courts reduce the number of new arrests and the severity of such re-arrests among mentally ill offenders. Similar analysis of mental health court completers and non-completers supports the prediction that a "full dose" of mental health treatment and court monitoring produce even fewer re-arrests.

Strategies for reducing police arrest in the context of an HIV prevention programme for female sex workers: evidence from structural interventions in Karnataka, South India.

PubMed

Bhattacharjee, Parinita; Isac, Shajy; McClarty, Leigh M; Mohan, Haranahalli L; Maddur, Srinath; Jagannath, Sunitha B; Venkataramaiah, Balasubramanya K; Moses, Stephen; Blanchard, James F; Gurnani, Vandana

2016-01-01

Female sex workers (FSWs) frequently experience violence in their work environments, violating their basic rights and increasing their vulnerability to HIV infection. Structural interventions addressing such violence are critical components of comprehensive HIV prevention programmes. We describe structural interventions developed to address violence against FSWs in the form of police arrest, in the context of the Bill and Melinda Gates Foundation's India AIDS Initiative (Avahan) in Karnataka, South India. We examine changes in FSW arrest between two consecutive time points during the intervention and identify characteristics that may increase FSW vulnerability to arrest in Karnataka. Structural interventions with police involved advocacy work with senior police officials, sensitization workshops, and integration of HIV and human rights topics in pre-service curricula. Programmes for FSWs aimed to enhance collectivization, empowerment and awareness about human rights and to introduce crisis response mechanisms. Three rounds of integrated behavioural and biological assessment surveys were conducted among FSWs from 2004 to 2011. We conducted bivariate and multivariate analyses using data from the second (R2) and third (R3) survey rounds to examine changes in arrests among FSWs over time and to assess associations between police arrest, and the sociodemographic and sex work-related characteristics of FSWs. Among 4110 FSWs surveyed, rates of ever being arrested by the police significantly decreased over time, from 9.9% in R2 to 6.1% in R3 (adjusted odds ratio (AOR) [95% CI]=0.63 [0.48 to 0.83]). Arrests in the preceding year significantly decreased, from 5.5% in R2 to 2.8% in R3 (AOR [95% CI]=0.59 [0.41 to 0.86]). FSWs arrested as part of arbitrary police raids also decreased from 49.6 to 19.5% (AOR [95% CI]=0.21 [0.11 to 0.42]). Certain characteristics, including financial dependency on sex work, street- or brothel-based solicitation and high client volumes, were found to significantly increase the odds of arrest for participants. Structural interventions addressing police arrest of FSWs are feasible to implement. Based on our findings, the design of violence prevention and response interventions in Karnataka can be tailored to focus on FSWs, who are disproportionately vulnerable to arrest by police. Context-specific structural interventions can reduce police arrests, create a safer work environment for FSWs and protect fundamental human rights.

Strategies for reducing police arrest in the context of an HIV prevention programme for female sex workers: evidence from structural interventions in Karnataka, South India

PubMed Central

Bhattacharjee, Parinita; Isac, Shajy; McClarty, Leigh M; Mohan, Haranahalli L; Maddur, Srinath; Jagannath, Sunitha B; Venkataramaiah, Balasubramanya K; Moses, Stephen; Blanchard, James F; Gurnani, Vandana

2016-01-01

Introduction Female sex workers (FSWs) frequently experience violence in their work environments, violating their basic rights and increasing their vulnerability to HIV infection. Structural interventions addressing such violence are critical components of comprehensive HIV prevention programmes. We describe structural interventions developed to address violence against FSWs in the form of police arrest, in the context of the Bill and Melinda Gates Foundation's India AIDS Initiative (Avahan) in Karnataka, South India. We examine changes in FSW arrest between two consecutive time points during the intervention and identify characteristics that may increase FSW vulnerability to arrest in Karnataka. Methods Structural interventions with police involved advocacy work with senior police officials, sensitization workshops, and integration of HIV and human rights topics in pre-service curricula. Programmes for FSWs aimed to enhance collectivization, empowerment and awareness about human rights and to introduce crisis response mechanisms. Three rounds of integrated behavioural and biological assessment surveys were conducted among FSWs from 2004 to 2011. We conducted bivariate and multivariate analyses using data from the second (R2) and third (R3) survey rounds to examine changes in arrests among FSWs over time and to assess associations between police arrest, and the sociodemographic and sex work-related characteristics of FSWs. Results Among 4110 FSWs surveyed, rates of ever being arrested by the police significantly decreased over time, from 9.9% in R2 to 6.1% in R3 (adjusted odds ratio (AOR) [95% CI]=0.63 [0.48 to 0.83]). Arrests in the preceding year significantly decreased, from 5.5% in R2 to 2.8% in R3 (AOR [95% CI]=0.59 [0.41 to 0.86]). FSWs arrested as part of arbitrary police raids also decreased from 49.6 to 19.5% (AOR [95% CI]=0.21 [0.11 to 0.42]). Certain characteristics, including financial dependency on sex work, street- or brothel-based solicitation and high client volumes, were found to significantly increase the odds of arrest for participants. Conclusion Structural interventions addressing police arrest of FSWs are feasible to implement. Based on our findings, the design of violence prevention and response interventions in Karnataka can be tailored to focus on FSWs, who are disproportionately vulnerable to arrest by police. Context-specific structural interventions can reduce police arrests, create a safer work environment for FSWs and protect fundamental human rights. PMID:27435708

Perturbation of the endothelial glycocalyx in post cardiac arrest syndrome.

PubMed

Grundmann, Sebastian; Fink, Katrin; Rabadzhieva, Lyubomira; Bourgeois, Natascha; Schwab, Tilmann; Moser, Martin; Bode, Christoph; Busch, Hans-Joerg

2012-06-01

The prognosis of immediate survivors of cardiac arrest remains poor, as the majority of these patients develops an inflammatory disorder known as the post-cardiac arrest syndrome (PCAS). Recently, the endothelial glycocalyx has been shown to be a key modulator of vascular permeability and inflammation, but its role in PCAS remains unknown. Plasma levels of the glycocalyx components syndecan-1, heparan sulfate and hyaluronic acid were measured in 25 patients after immediate survival of cardiac arrest during different phases of PCAS. Twelve hemodynamically stable patients with acute coronary syndrome served as controls. Cardiac arrest resulted in a significant increase in syndecan-1, heparan sulfate and hyaluronic acid levels compared to controls, indicating a shedding of the endothelial glycocalyx as a pathophysiological component of the post cardiac arrest syndrome. The time course differed between the individual glycocalyx components, with a higher increase of syndecan-1 in the early phase of PCAS (2.8-fold increase vs. controls) and a later peak of heparan sulfate (1.7-fold increase) and hyaluronic acid (2-fold increase) in the intermediate phase. Only the plasma levels of syndecan-1 correlated positively with the duration of CPR and negatively with the glycocalyx-protective protease inhibitor antithrombin III. Plasma levels of both syndecan-1 and heparan sulfate were higher in eventual non-survivors than in survivors of cardiac arrest. Our data for the first time demonstrates a perturbation of the endothelial glycocalyx in immediate survivors of cardiac arrest and indicate a potential important role of this endothelial surface layer in the development of post-cardiac arrest syndrome. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Early Cardiac Arrest in Patients Hospitalized With Pneumonia

PubMed Central

Yuen, Trevor C.; McConville, John F.; Kress, John P.; VandenHoek, Terry L.; Hall, Jesse B.; Edelson, Dana P.

2012-01-01

Background: Pneumonia is the leading infectious cause of death. Early deterioration and death commonly result from progressive sepsis, shock, respiratory failure, and cardiac complications. Recent data suggest that cardiac arrest may also be common, yet few previous studies have addressed this. Accordingly, we sought to characterize early cardiac arrest in patients who are hospitalized with coexisting pneumonia. Methods: We performed a retrospective analysis of a multicenter cardiac arrest database, with data from > 500 North American hospitals. We included in-hospital cardiac arrest events that occurred in community-dwelling adults with pneumonia within the first 72 h after hospital admission. We compared patient and event characteristics for patients with and without pneumonia. For patients with pneumonia, we also compared events according to event location. Results: We identified 4,453 episodes of early cardiac arrest in patients who were hospitalized with pneumonia. Among patients with preexisting pneumonia, only 36.5% were receiving mechanical ventilation and only 33.3% were receiving infusions of vasoactive drugs prior to cardiac arrest. Only 52.3% of patients on the ward were receiving ECG monitoring prior to cardiac arrest. Shockable rhythms were uncommon in all patients with pneumonia (ventricular tachycardia or fibrillation, 14.8%). Patients on the ward were significantly older than patients in the ICU. Conclusions: In patients with preexisting pneumonia, cardiac arrest may occur in the absence of preceding shock or respiratory failure. Physicians should be alert to the possibility of abrupt cardiopulmonary collapse, and future studies should address this possibility. The mechanism may involve myocardial ischemia, a maladaptive response to hypoxia, sepsis-related cardiomyopathy, or other phenomena. PMID:22194592

Smoking marijuana in public: the spatial and policy shift in New York City arrests, 1992–2003

PubMed Central

Golub, Andrew; Johnson, Bruce D; Dunlap, Eloise

2006-01-01

Background During the 1990s, the New York Police Department (NYPD) greatly expanded arrests for smoking marijuana in public view (MPV). By 2000, MPV accounted for 15% of all arrests. The NYPD's supporters report this arrest activity is just part of quality-of-life (QOL) policing, which seeks to promote order in public locations by aggressively patrolling for behaviors that offend the general population. The NYPD's critics contend the NYPD has disproportionately targeted poor, black and Hispanic communities. Methods This paper analyzes the geographic distribution of MPV arrests from 1992 to 2003 to evaluate these alternative perspectives. A sequence of maps identify that the focus of MPV arrests shifted over time. Results In the early 1990s, most MPV arrests were recorded in the lower half of Manhattan (NYC's business and cultural center) and by the transit police. However, in the later 1990s and into the 2000s, most MPV arrests were recorded in high poverty, minority communities outside the lower Manhattan area and by the NYPD's policing of low-income housing projects. Conclusion These findings suggest that current levels of MPV arrests in NYC may not be justifiable, at least based solely on the purpose of QOL policing. Accordingly, we suggest the NYPD seriously consider less stringent measures for public marijuana smokers, especially for use outside of highly public locations in recessed locations hidden from open view (like the stairwell of a housing project). Alternatives could include Desk Appearance Tickets, fines, or simply requiring smokers to desist, discard their product, and move along. PMID:16889660

Release from meiotic arrest in ascidian eggs requires the activity of two phosphatases but not CaMKII

PubMed Central

Levasseur, Mark; Dumollard, Remi; Chambon, Jean-Philippe; Hebras, Celine; Sinclair, Maureen; Whitaker, Michael; McDougall, Alex

2013-01-01

The fertilising sperm triggers a transient Ca2+ increase that releases eggs from cell cycle arrest in the vast majority of animal eggs. In vertebrate eggs, Erp1, an APC/Ccdc20 inhibitor, links release from metaphase II arrest with the Ca2+ transient and its degradation is triggered by the Ca2+-induced activation of CaMKII. By contrast, many invertebrate groups have mature eggs that arrest at metaphase I, and these species do not possess the CaMKII target Erp1 in their genomes. As a consequence, it is unknown exactly how cell cycle arrest at metaphase I is achieved and how the fertilisation Ca2+ transient overcomes the arrest in the vast majority of animal species. Using live-cell imaging with a novel cyclin reporter to study cell cycle arrest and its release in urochordate ascidians, the closest living invertebrate group to the vertebrates, we have identified a new signalling pathway for cell cycle resumption in which CaMKII plays no part. Instead, we find that the Ca2+-activated phosphatase calcineurin (CN) is required for egg activation. Moreover, we demonstrate that parthenogenetic activation of metaphase I-arrested eggs by MEK inhibition, independent of a Ca2+ increase, requires the activity of a second egg phosphatase: PP2A. Furthermore, PP2A activity, together with CN, is required for normal egg activation during fertilisation. As ascidians are a sister group of the vertebrates, we discuss these findings in relation to cell cycle arrest and egg activation in chordates. PMID:24194472

An evaluation of three methods of in-hospital cardiac arrest educational debriefing: The cardiopulmonary resuscitation debriefing study.

PubMed

Couper, Keith; Kimani, Peter K; Davies, Robin P; Baker, Annalie; Davies, Michelle; Husselbee, Natalie; Melody, Teresa; Griffiths, Frances; Perkins, Gavin D

2016-08-01

The use of cardiac arrest educational debriefing has been associated with improvements in cardiopulmonary resuscitation (CPR) quality and patient outcome. The practical challenges associated with delivering some debriefing approaches may not be generalisable to the UK health setting. The aim of this study was to evaluate the deliverability and effectiveness of three cardiac arrest debriefing approaches that were tailored to UK working practice. We undertook a before/after study at three hospital sites. During the post-intervention period of the study, three cardiac arrest educational debriefing models were implemented at study hospitals (one model per hospital). To evaluate the effectiveness of the interventions, CPR quality and patient outcome data were collected from consecutive adult cardiac arrest events attended by the hospital cardiac arrest team. The primary outcome was chest compression depth. Between November 2011 and July 2014, 1198 cardiac arrest events were eligible for study inclusion (782 pre-intervention; 416 post-intervention). The quality of CPR was high at baseline. During the post-intervention period, cardiac arrest debriefing interventions were delivered to 191 clinicians on 344 occasions. Debriefing interventions were deliverable in practice, but were not associated with a clinically important improvement in CPR quality. The interventions had no effect on patient outcome. The delivery of these cardiac arrest educational debriefing strategies was feasible, but did not have a large effect on CPR quality. This may be attributable to the high-quality of CPR being delivered in study hospitals at baseline. ISRCTN39758339. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

How does early adulthood arrest alter substance use behavior? Are there differential effects by race/ethnicity and gender?

PubMed Central

Hassett-Walker, Connie; Walsemann, Katrina; Bell, Bethany; Fisk, Calley; Shadden, Mark; Zhou, Weidan

2017-01-01

Purpose Much criminal justice research has ignored racial/ethnic and gender differences in substance use subsequent to criminal justice involvement. This paper investigated how early adulthood arrest (i.e., 18 to 21 years of age) influences individuals’ subsequent transitions from non-substance use to substance use, and substance use to non-substance use through age 30. We also consider if these relationships differ by race/ethnicity and gender. Processes proscribed by labeling theory subsequent to getting arrested are considered. Methods We analyzed 15 waves of data from the National Longitudinal Survey of Youth 1997. Multinomial logistic regressions were performed using Stata software version 14. Results We found racial/ethnic differences in the effect of arrest on subsequent substance use, particularly marijuana. Being arrested was associated with shifting non-binge drinkers and non-marijuana users into binge drinking and marijuana use; as well as shifting binge drinkers and marijuana users into non-use. This pattern was most evident among White and Black men. For Black men, the association between arrest and both becoming a binge drinker and becoming a non-binge drinker was experienced most strongly during their early twenties. Women’s patterns in substance use transitions following an arrest were less clear than for the men. Conclusion Some results, particularly transitioning into marijuana use, offer qualified support for processes proscribed through labeling theory. Findings that arrest shifts individuals into non-marijuana use suggest that factors not accounted for by labeling theory – arrest serving as a teachable moment for those using substances - may be at play. PMID:29123972

[Anesthesia-related cardiac arrest in children. Data from a tertiary referral hospital registry].

PubMed

Sanabria-Carretero, P; Ochoa-Osorio, C; Martín-Vega, A; Lahoz-Ramón, A; Rodríguez-Pérez, E; Reinoso-Barbero, F; Goldman-Tarlovsky, L

2013-10-01

The aim of this study is to analyze the cardiac arrests related to anesthesia in a tertiary children's hospital, in order to identify risk factors that would lead to opportunities for improvement. A 5-year retrospective study was conducted on anesthesia related cardiac arrest occurring in pediatric patients. All urgent and elective anesthetic procedures performed by anesthesiologists were included. Data collected included patient characteristics, the procedure, the probable cause, and outcome of the cardiac arrest. Odds ratio was calculated by univariate analysis to determine the clinical factors associated with cardiac arrest and mortality. There were a total of 15 cardiac arrests related to anesthesia in 43,391 anesthetic procedures (3.4 per 10,000), with an incidence in children with ASA I-II versus ASA≥III of 0.28 and 19.27 per 10,000, respectively. The main risk factors were children ASA≥III (P<.001), less than one month old (P<.001), less than one year old (P<.001), emergency procedures (P<.01), cardiac procedures (P<.001) and procedures performed in the catheterization laboratory (P<.05). The main causes of cardiac arrest were cardiovascular (53.3%), mainly due to hypovolemia, and cardiovascular depression associated with induction of anesthesia, followed by respiratory causes (20%), and medication causes (20%). The incidence of mortality and neurological injury within the first 24h after the cardiac arrest was 0.92 and 1.38 per 10,000, respectively. The mortality in the first 3 months was 1.6 per 10,000. The main causes of death were ASA≥III, age under one year, pulmonary arterial hypertension, cardiac arrest in areas remote from the surgery area, a duration of cardiopulmonary resuscitation over 20min, and when hypothermia was not applied after cardiac arrest. The main risk factors for cardiac arrest were ASA≥III, age under one year, emergency procedures, cardiology procedures and procedures performed in the catheterization laboratory. The main cause of the cardiac arrest was due mainly to cardiovascular hypovolemia. All patients who died or had neurological injury were ASA≥III. Pulmonary arterial hypertension is a risk of anesthesia-related mortality. Copyright © 2012 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

Appropriating Written French: Literacy Practices in a Parisian Elementary Classroom

ERIC Educational Resources Information Center

Rockwell, Elsie

2012-01-01

In this article, I examine French language instruction in an elementary classroom serving primarily children of Afro-French immigrants in Paris. I show that a prevalent French language ideology privileges written over oral expression and associates full mastery of written French with rational thought and full inclusion in the French polity. This…

Gender studies and the role of women in physics

NASA Astrophysics Data System (ADS)

Horton, K. Renee; Holbrook, J. C.

2013-03-01

While many physicists care about improving the success of women in physics, research on effective intervention strategies has been meager. What research that does exist focuses largely on the dynamics of under-representation: the factors that discourage women from choosing and remaining committed to the physics community. Rather than focusing on these deficits, this workshop set out to provide tools physicists can use to produce, analyze, and apply evidence about what works for women.

Beyond the Standard Models

NASA Astrophysics Data System (ADS)

Weinberg, Steven

2014-03-01

I am grateful for this chance to return to Stockholm and speak in honor of a great theoretical physicist, Oskar Klein. All physicists know of Klein's famous contributions to quantum mechanics, recalled to us when we speak of the Klein-Nishina formula, the Klein paradox, and the Klein-Gordon equation. More than that, Klein seems to have had the gift of prophecy -- he could see farther into the future of physics than is given to most of us...

Theory of Anion-Substituted Nitrogen-Bearing III-V Alloys

DTIC Science & Technology

1998-07-20

was found by Zunger group). When more than 4% arsenic is incorporated into GaN in an ordered array, the band gap closes . Calculations of the...arsenic is incorporated into GaN in an ordered array, the band gap closes . Calculations of the properties of random alloys predict smaller bowing...BEARING lll-V ALLOYS Prepared by: M. A. Berding, Senior Research Physicist M. van Schilfgaarde, Senior Research Physicist A. Sher, Associate Director

PARTICLE PHYSICS: CERN Collider Glimpses Supersymmetry--Maybe.

PubMed

Seife, C

2000-07-14

Last week, particle physicists at the CERN laboratory in Switzerland announced that by smashing together matter and antimatter in four experiments, they detected an unexpected effect in the sprays of particles that ensued. The anomaly is subtle, and physicists caution that it might still be a statistical fluke. If confirmed, however, it could mark the long-sought discovery of a whole zoo of new particles--and the end of a long-standing model of particle physics.

Guide of good practices for occupational radiological protection in plutonium facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-06-01

This Technical Standard (TS) does not contain any new requirements. Its purpose is to provide guides to good practice, update existing reference material, and discuss practical lessons learned relevant to the safe handling of plutonium. the technical rationale is given to allow US Department of Energy (DOE) health physicists to adapt the recommendations to similar situations throughout the DOE complex. Generally, DOE contractor health physicists will be responsible to implement radiation protection activities at DOE facilities and DOE health physicists will be responsible for oversight of those activities. This guidance is meant to be useful for both efforts. This TSmore » replaces PNL-6534, Health Physics Manual of Good Practices for Plutonium Facilities, by providing more complete and current information and by emphasizing the situations that are typical of DOE`s current plutonium operations; safe storage, decontamination, and decommissioning (environmental restoration); and weapons disassembly.« less

Physics and Diplomacy: A True Story

NASA Astrophysics Data System (ADS)

Sessoms, Allen

2017-01-01

Physics has played a prominent role in U.S. diplomacy since the development of nuclear weapons during World War II. The discipline expanded its reach during the Atoms for Peace initiative of president Eisenhower and continued through the Cold War with the Soviet Union. Physics maintains a prominent role in the diplomatic dialogue through efforts in the nuclear non-proliferation arena and in major international science collaborations such as in experiments at CERN, ITER and the International Space Station. Physics has also served as the template for the much broader impact of science on diplomacy. For example, climate change, energy efficiency and ocean science have all benefitted from the path blazed by physicists. But how effective have physicists been in steering clear of political dynamics while trying to infuse scientific facts into policy debates? This talk will consider this through the eyes of a physicist who has spent many years providing advice to policy makers, both inside and outside of government.

Woman in Physics in Slovenia

NASA Astrophysics Data System (ADS)

Zeleznik, Nadja; Conradi, Marjetka; Remskar, Maja

2009-04-01

Slovenian female physicists are organized in an informal network that incorporates more than 100 women working in research, academia, government, and industry. In the past three years we have accomplished several actions in order to motivate young girls and students to pursue physics. Our main achievement was publishing the monograph Physics—My Education in September 2007. The book includes 79 autobiographic contributions of female physicists presenting their life and work in different areas: science (institutes and universities), teaching, industry, and government. We have also organized an exhibition about Slovene women in physics, presenting the very first female physicists and all the next generations. A very popular item among women and men was also a T-shirt with our logo. By selling the books and T-shirts we have collected money for scholarships for female students of physics. The first four scholarships were awarded on March 8, 2008, in the spirit of the International Women's Day.

Ask not what physics can do for biology—ask what biology can do for physics

NASA Astrophysics Data System (ADS)

Frauenfelder, Hans

2014-10-01

Stan Ulam, the famous mathematician, said once to Hans Frauenfelder: ‘Ask not what Physics can do for biology, ask what biology can do for physics’. The interaction between biologists and physicists is a two-way street. Biology reveals the secrets of complex systems, physics provides the physical tools and the theoretical concepts to understand the complexity. The perspective gives a personal view of the path to some of the physical concepts that are relevant for biology and physics (Frauenfelder et al 1999 Rev. Mod. Phys. 71 S419-S442). Schrödinger’s book (Schrödinger 1944 What is Life? (Cambridge: Cambridge University Press)), loved by physicists and hated by eminent biologists (Dronamraju 1999 Genetics 153 1071-6), still shows how a great physicist looked at biology well before the first protein structure was known.

Workshop on Models for Plasma Spectroscopy

NASA Astrophysics Data System (ADS)

1993-09-01

A meeting was held at St. Johns College, Oxford from Monday 27th to Thursday 30th of September 1993 to bring together a group of physicists working on computational modelling of plasma spectroscopy. The group came from the UK, France, Israel and the USA. The meeting was organized by myself, Dr. Steven Rose of RAL and Dr. R.W. Lee of LLNL. It was funded by the U.S. European Office of Aerospace Research and Development and by LLNL. The meeting grew out of a wish by a group of core participants to make available to practicing plasma physicists (particularly those engaged in the design and analysis of experiments) sophisticated numerical models of plasma physics. Additional plasma physicists attended the meeting in Oxford by invitation. These were experimentalists and users of plasma physics simulation codes whose input to the meeting was to advise the core group as to what was really needed.

MO-DE-201-03: This course presents a review of radiologic anatomy and physiology as it applies to projection radiography, fluoroscopy, CT, MRI, U/S, and nuclear medicine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fahey, F.

Fundamental knowledge of radiologic anatomy and physiology is critical for medical physicists. Many physicists are exposed to this topic only in graduate school, and knowledge is seldom formally evaluated or assessed after Part I of the ABR exam. Successful interactions with clinicians, including surgeons, radiologists, and oncologists requires that the medical physicist possess this knowledge. This course presents a review of radiologic anatomy and physiology as it applies to projection radiography, fluoroscopy, CT, MRI, U/S, and nuclear medicine. We will review structural anatomy, manipulation of tissue contrast, the marriage between anatomy and physiology, and explore how medical imaging exploits normalmore » and pathological processes in the body to generate contrast. Learning Objectives: Review radiologic anatomy. Examine techniques to manipulate tissue contrast in radiology. Integrate anatomy and physiology in molecular imaging.« less

Heinrich Hertz and Philipp Lenard: Two Distinguished Physicists, Two Disparate Men

NASA Astrophysics Data System (ADS)

Mulligan, Joseph F.

1999-12-01

Heinrich Hertz (1857-1894) and Philipp Lenard (1862-1947) both had distinguished careers as physicists. They were together in Bonn from April 1891 to January 1894, Hertz as Director of the Bonn Physics Institute, and Lenard as his assistant. Each did important experimental work on cathode rays and the photoelectric effect, and in 1905 Lenard received the Nobel Prize for his work in these fields. Lenard had great respect and admiration for Hertz before going to Bonn and while there, but gradually allowed his esteem for his mentor (who died in 1894) to diminish as Lenard became increasingly anti-Semitic and involved in National Socialism and the Nazi movement. This article illustrates how differences in their characters and personalities, together with the tragic events of the Great War and its aftermath, resulted in Hertz deservedly being much more highly regarded today both as a physicist and as a man than is Lenard.

Thirty years from now: future physics contributions in nuclear medicine.

PubMed

Bailey, Dale L

2014-12-01

This paper is the first in a series of invited perspectives by pioneers of nuclear medicine imaging and physics. A medical physicist and a nuclear medicine physician each take a backward and a forward look at the contributions of physics to nuclear medicine. Here, we provide a forward look from the medical physicist's perspective. The author examines a number of developments in nuclear medicine and discusses the ways in which physics has contributed to these. Future developments are postulated in the context of an increasingly personalised approach to medical diagnostics and therapies. A skill set for the next generation of medical physicists in nuclear medicine is proposed in the context of the increasing complexity of 'Molecular Imaging' in the next three decades. The author sees a shift away from 'traditional' roles in instrumentation QA to more innovative approaches in understanding radiobiology and human disease.

A special report of current state of the medical physicist workforce — results of the 2012 ASTRO Comprehensive Workforce Study

PubMed Central

Arnone, Anna; Sillanpaa, Jussi K; Yu, Yan; Mills, Michael D.

2015-01-01

The medical physics profession is undergoing significant changes. Starting in 2014, candidates registering for certification exams by the American Board of Radiology must have completed a CAMPEP‐accredited residency. This requirement, along with tightened state regulations, uncertainty in future reimbursement, and a stronger emphasis on board certification, have raised questions concerning the state of the medical physics workforce and its ability to adapt to changing requirements. In 2012, ASTRO conducted a workforce study of the comprehensive field of radiation oncology. This article reviews the findings of the medical physics section of the study, including age and gender distribution, educational background, workload, and primary work setting. We also report on job satisfaction, the perceived supply and demand of medical physicists, and the medical physicists' main concerns pertaining to patient safety and quality assurance. PACS number: 87.90 PMID:26103483

SU-B-BRA-07: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halvorsen, P.

2016-06-15

In the current rapidly changing Healthcare environment, many groups are competing for limited resources. How can medical physicists position themselves to be a relevant stakeholder in the discussion of how those resources are allocated Our value goes beyond what can be shown in a business plan and is heavily involved with safety and quality. Three areas will be explored: What is our value? Who needs to receive that message? How do we communicate that message? To help frame the discussion in terms of how other stakeholders may view the value of medical physicists, a physician and an administrator will presentmore » their perspective. Lastly, a multidisciplinary panel will present real life examples of strategies that can be utilized today to establish the value of medical physicists. The presentation of these examples will lead into an interactive question and answer time. V. Willcut, I work for Elekta. There was no research associated with this talk.« less

SU-B-BRA-09: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willcut, V.

2016-06-15

In the current rapidly changing Healthcare environment, many groups are competing for limited resources. How can medical physicists position themselves to be a relevant stakeholder in the discussion of how those resources are allocated Our value goes beyond what can be shown in a business plan and is heavily involved with safety and quality. Three areas will be explored: What is our value? Who needs to receive that message? How do we communicate that message? To help frame the discussion in terms of how other stakeholders may view the value of medical physicists, a physician and an administrator will presentmore » their perspective. Lastly, a multidisciplinary panel will present real life examples of strategies that can be utilized today to establish the value of medical physicists. The presentation of these examples will lead into an interactive question and answer time. V. Willcut, I work for Elekta. There was no research associated with this talk.« less

SU-B-BRA-08: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hazle, J.

2016-06-15

In the current rapidly changing Healthcare environment, many groups are competing for limited resources. How can medical physicists position themselves to be a relevant stakeholder in the discussion of how those resources are allocated Our value goes beyond what can be shown in a business plan and is heavily involved with safety and quality. Three areas will be explored: What is our value? Who needs to receive that message? How do we communicate that message? To help frame the discussion in terms of how other stakeholders may view the value of medical physicists, a physician and an administrator will presentmore » their perspective. Lastly, a multidisciplinary panel will present real life examples of strategies that can be utilized today to establish the value of medical physicists. The presentation of these examples will lead into an interactive question and answer time. V. Willcut, I work for Elekta. There was no research associated with this talk.« less

SU-B-BRA-05: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pavord, D.

2016-06-15

In the current rapidly changing Healthcare environment, many groups are competing for limited resources. How can medical physicists position themselves to be a relevant stakeholder in the discussion of how those resources are allocated Our value goes beyond what can be shown in a business plan and is heavily involved with safety and quality. Three areas will be explored: What is our value? Who needs to receive that message? How do we communicate that message? To help frame the discussion in terms of how other stakeholders may view the value of medical physicists, a physician and an administrator will presentmore » their perspective. Lastly, a multidisciplinary panel will present real life examples of strategies that can be utilized today to establish the value of medical physicists. The presentation of these examples will lead into an interactive question and answer time. V. Willcut, I work for Elekta. There was no research associated with this talk.« less

SU-B-BRA-06: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, J.

2016-06-15

In the current rapidly changing Healthcare environment, many groups are competing for limited resources. How can medical physicists position themselves to be a relevant stakeholder in the discussion of how those resources are allocated Our value goes beyond what can be shown in a business plan and is heavily involved with safety and quality. Three areas will be explored: What is our value? Who needs to receive that message? How do we communicate that message? To help frame the discussion in terms of how other stakeholders may view the value of medical physicists, a physician and an administrator will presentmore » their perspective. Lastly, a multidisciplinary panel will present real life examples of strategies that can be utilized today to establish the value of medical physicists. The presentation of these examples will lead into an interactive question and answer time. V. Willcut, I work for Elekta. There was no research associated with this talk.« less

[After your heart arrest, would you like to test a medicinal elixir?].

PubMed

Carron, P-N; Hugli, O; Liaudet, L; Yersin, B

2005-02-09

So far, cardiac arrest is still associated with high mortality or severe neurological disability in survivors. At the tissue level, cardiac arrest results into an acute condition of generalized hypoxia. A better understanding of the pathophysiology of ischemia-reperfusion and of the inflammatory response that develops after cardiac arrest could help to design novel therapeutic strategies in the future. It seems unlikely that a single drug, acting as a , might be able to improve survival or neurological prognosis. Lessons learned from pathophysiological mechanisms rather indicate that combined therapies, involving thrombolysis, neuroprotective agents, antioxidants and anti-inflammatory molecules, together with temperature cooling, might represent helpful strategies to improve patient's outcome after cardiac arrest.

A model of survival following pre-hospital cardiac arrest based on the Victorian Ambulance Cardiac Arrest Register.

PubMed

Fridman, Masha; Barnes, Vanessa; Whyman, Andrew; Currell, Alex; Bernard, Stephen; Walker, Tony; Smith, Karen L

2007-11-01

This study describes the epidemiology of sudden cardiac arrest patients in Victoria, Australia, as captured via the Victorian Ambulance Cardiac Arrest Register (VACAR). We used the VACAR data to construct a new model of out-of-hospital cardiac arrest (OHCA), which was specified in accordance with observed trends. All cases of cardiac arrest in Victoria that were attended by Victorian ambulance services during the period of 2002-2005. Overall survival to hospital discharge was 3.8% among 18,827 cases of OHCA. Survival was 15.7% among 1726 bystander witnessed, adult cardiac arrests of presumed cardiac aetiology, presenting in ventricular fibrillation or ventricular tachycardia (VF/VT), where resuscitation was attempted. In multivariate logistic regression analysis, bystander CPR, cardiac arrest (CA) location, response time, age and sex were predictors of VF/VT, which, in turn, was a strong predictor of survival. The same factors that affected VF/VT made an additional contribution to survival. However, for bystander CPR, CA location and response time this additional contribution was limited to VF/VT patients only. There was no detectable association between survival and age younger than 60 years or response time over 15min. The new model accounts for relationships among predictors of survival. These relationships indicate that interventions such as reduced response times and bystander CPR act in multiple ways to improve survival.

Discrimination, arrest history, and major depressive disorder in the U.S. Black population.

PubMed

Anglin, Deidre M; Lighty, Quenesha; Yang, Lawrence H; Greenspoon, Michelle; Miles, Rashun J; Slonim, Tzachi; Isaac, Kathleen; Brown, Monique J

2014-09-30

Everyday discrimination contributes negatively to depressive symptomatology among Blacks in the US and being arrested could add to this depression. Using data from the National Survey on American Life, the present study determined the association between an arrest history and major depressive disorder (MDD), while accounting for discrimination among African Americans, US-born Afro-Caribbeans and first-generation Black immigrants. Findings from logistic regression analyses adjusted for discrimination suggested an arrest history is associated with 12-month MDD (Adjusted OR=1.47; 95% CI=1.02-2.10) and lifetime MDD (Adjusted OR=1.56 CI=1.17-2.09). Accounting for drug and alcohol dependence attenuated the association between arrest history and 12-month MDD, but not lifetime MDD. The associations between arrest history and both 12-month and lifetime MDD, and discrimination and lifetime MDD varied by ethnic/immigrant group. Specifically, while the association between arrest history and MDD (both 12-month and lifetime) was strongest among US-born Afro-Caribbeans, evidence consistent with the immigrant paradox, the association between discrimination and lifetime MDD was particularly relevant for first-generation Black immigrants, suggesting discrimination may hinder the protection of first-generation status. Mental health prevention and treatment programs should target the stress associated with being arrested and experiencing discrimination among US Blacks. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chromosomal Aneuploidies and Early Embryonic Developmental Arrest

PubMed Central

Maurer, Maria; Ebner, Thomas; Puchner, Manuela; Mayer, Richard Bernhard; Shebl, Omar; Oppelt, Peter; Duba, Hans-Christoph

2015-01-01

Background Selecting the best embryo for transfer, with the highest chance of achieving a vital pregnancy, is a major goal in current in vitro fertilization (IVF) technology. The high rate of embryonic developmental arrest during IVF treatment is one of the limitations in achieving this goal. Chromosomal abnormalities are possibly linked with chromosomal arrest and selection against abnormal fertilization products. The objective of this study was to evaluate the frequency and type of chromosomal abnormalities in preimplantation embryos with developmental arrest. Materials and Methods This cohort study included blastomeres of embryos with early developmental arrest that were biopsied and analyzed by fluorescence in-situ hybridization (FISH) with probes for chromosomes 13, 16, 18, 21 and 22. Forty-five couples undergoing IVF treatment were included, and 119 arrested embryos were biopsied. All probes were obtained from the Kinderwunsch Zentrum, Linz, Austria, between August 2009 and August 2011. Results Of these embryos, 31.6% were normal for all chromosomes tested, and 68.4% were abnormal. Eleven embryos were uniformly aneuploid, 20 were polyploid, 3 were haploid, 11 displayed mosaicism and 22 embryos exhibited chaotic chromosomal complement. Conclusion Nearly 70% of arrested embryos exhibit chromosomal errors, making chromosomal abnormalities a major cause of embryonic arrest and may be a further explanation for the high developmental failure rates during culture of the embryos in the IVF setting. PMID:26644858

Identifying Important Gaps in Randomized Controlled Trials of Adult Cardiac Arrest Treatments: A Systematic Review of the Published Literature.

PubMed

Sinha, Shashank S; Sukul, Devraj; Lazarus, John J; Polavarapu, Vivek; Chan, Paul S; Neumar, Robert W; Nallamothu, Brahmajee K

2016-11-01

Cardiac arrest is a major public health concern worldwide. The extent and types of randomized controlled trials (RCT)-our most reliable source of clinical evidence-conducted in these high-risk patients over recent years are largely unknown. We performed a systematic review, identifying all RCTs published in PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library from 1995 to 2014 that focused on the acute treatment of nontraumatic cardiac arrest in adults. We then extracted data on the setting of study populations, types and timing of interventions studied, risk of bias, outcomes reported, and how these factors have changed over time. Over this 20-year period, 92 RCTs were published containing 64 309 patients (median, 225.5 per trial). Of these, 81 RCTs (88.0%) involved out-of-hospital cardiac arrest, whereas 4 (4.3%) involved in-hospital cardiac arrest and 7 (7.6%) included both. Eighteen RCTs (19.6%) were performed in the United States, 68 (73.9%) were performed outside the United States, and 6 (6.5%) were performed in both settings. Thirty-eight RCTs (41.3%) evaluated drug therapy, 39 (42.4%) evaluated device therapy, and 15 (16.3%) evaluated protocol improvements. Seventy-four RCTs (80.4%) examined interventions during the cardiac arrest, 15 (16.3%) examined post cardiac arrest treatment, and 3 (3.3%) studied both. Overall, reporting of the risk of bias was limited. The most common outcome reported was return of spontaneous circulation: 86 (93.5%) with only 22 (23.9%) reporting survival beyond 6 months. Fifty-three RCTs (57.6%) reported global ordinal outcomes, whereas 15 (16.3%) reported quality-of-life. RCTs in the past 5 years were more likely to be focused on protocol improvements and postcardiac arrest care. Important gaps in RCTs of cardiac arrest treatments exist, especially those examining in-hospital cardiac arrest, protocol improvement, postcardiac arrest care, and long-term or quality-of-life outcomes. © 2016 American Heart Association, Inc.

Resuscitation Practices Associated With Survival After In-Hospital Cardiac Arrest: A Nationwide Survey.

PubMed

Chan, Paul S; Krein, Sarah L; Tang, Fengming; Iwashyna, Theodore J; Harrod, Molly; Kennedy, Mary; Lehrich, Jessica; Kronick, Steven; Nallamothu, Brahmajee K

2016-05-01

Although survival of patients with in-hospital cardiac arrest varies markedly among hospitals, specific resuscitation practices that distinguish sites with higher cardiac arrest survival rates remain unknown. To identify resuscitation practices associated with higher rates of in-hospital cardiac arrest survival. Nationwide survey of resuscitation practices at hospitals participating in the Get With the Guidelines-Resuscitation registry and with 20 or more adult in-hospital cardiac arrest cases from January 1, 2012, through December 31, 2013. Data analysis was performed from June 10 to December 22, 2015. Risk-standardized survival rates for cardiac arrest were calculated at each hospital and were then used to categorize hospitals into quintiles of performance. The association between resuscitation practices and quintiles of survival was evaluated using hierarchical proportional odds logistic regression models. Overall, 150 (78.1%) of 192 eligible hospitals completed the study survey, and 131 facilities with 20 or more adult in-hospital cardiac arrest cases comprised the final study cohort. Risk-standardized survival rates after in-hospital cardiac arrest varied substantially (median, 23.7%; range, 9.2%-37.5%). Several resuscitation practices were associated with survival on bivariate analysis, although only 3 were significant after multivariable adjustment: monitoring for interruptions in chest compressions (adjusted odds ratio [OR] for being in a higher survival quintile category, 2.71; 95% CI, 1.24-5.93; P = .01), reviewing cardiac arrest cases monthly (adjusted OR for being in a higher survival quintile category, 8.55; 95% CI, 1.79-40.00) or quarterly (OR, 6.85; 95% CI, 1.49-31.30; P = .03), and adequate resuscitation training (adjusted OR, 3.23; 95% CI, 1.21-8.33; P = .02). Using survey information from acute care hospitals participating in a national quality improvement registry, we identified 3 resuscitation strategies associated with higher hospital rates of survival for patients with in-hospital cardiac arrest. These strategies can form the foundation for best practices for resuscitation care at hospitals given the high incidence and variation in survival for in-hospital cardiac arrest.

Identifying Important Gaps in Randomized Controlled Trials of Adult Cardiac Arrest Treatments: A Systematic Review of the Published Literature

PubMed Central

Sinha, Shashank S.; Sukul, Devraj; Lazarus, John J.; Polavarapu, Vivek; Chan, Paul S.; Neumar, Robert W.; Nallamothu, Brahmajee K.

2016-01-01

Background Cardiac arrests are a major public health concern worldwide. The extent and types of randomized controlled trials (RCTs) – our most reliable source of clinical evidence – conducted in these high-risk patients over recent years are largely unknown. Methods and Results We performed a systematic review, identifying all RCTs published in PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library from 1995 to 2014 that focused on acute treatment of non-traumatic cardiac arrest in adults. We then extracted data on the setting of study populations, types and timing of interventions studied, risk of bias, outcomes reported and how these factors have changed over time. Over this twenty-year period, 92 RCTs were published containing 64,309 patients (median, 225.5 per trial). Of these, 81 RCTs (88.0%) involved out-of-hospital cardiac arrest whereas 4 (4.3%) involved in-hospital cardiac arrest and 7 (7.6%) included both. Eighteen RCTs (19.6%) were performed in the U.S., 68 (73.9%) were performed outside the U.S., and 6 (6.5%) were performed in both settings. Thirty-eight RCTs (41.3%) evaluated drug therapy, 39 (42.4%) evaluated device therapy, and 15 (16.3%) evaluated protocol improvements. Seventy-four RCTs (80.4%) examined interventions during the cardiac arrest, 15 (16.3%) examined post-cardiac arrest treatment, and 3 (3.3%) studied both. Overall, reporting of risk of bias was limited. The most common outcome reported was ROSC: 86 (93.5%) with only 22 (23.9%) reporting survival beyond 6 months. Fifty-three RCTs (57.6%) reported global ordinal outcomes whereas 15 (16.3%) reported quality-of-life. RCTs in the last 5 years were more likely to be focused on protocol improvement and post-cardiac arrest care. Conclusions Important gaps in RCTs of cardiac arrest treatments exist, especially those examining in-hospital cardiac arrest, protocol improvement, post-cardiac arrest care, and long-term or quality-of-life outcomes. PMID:27756794

dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest.

PubMed

Kaplan, Rebecca E W; Chen, Yutao; Moore, Brad T; Jordan, James M; Maxwell, Colin S; Schindler, Adam J; Baugh, L Ryan

2015-12-01

Nutrient availability has profound influence on development. In the nematode C. elegans, nutrient availability governs post-embryonic development. L1-stage larvae remain in a state of developmental arrest after hatching until they feed. This "L1 arrest" (or "L1 diapause") is associated with increased stress resistance, supporting starvation survival. Loss of the transcription factor daf-16/FOXO, an effector of insulin/IGF signaling, results in arrest-defective and starvation-sensitive phenotypes. We show that daf-16/FOXO regulates L1 arrest cell-nonautonomously, suggesting that insulin/IGF signaling regulates at least one additional signaling pathway. We used mRNA-seq to identify candidate signaling molecules affected by daf-16/FOXO during L1 arrest. dbl-1/TGF-β, a ligand for the Sma/Mab pathway, daf-12/NHR and daf-36/oxygenase, an upstream component of the daf-12 steroid hormone signaling pathway, were up-regulated during L1 arrest in a daf-16/FOXO mutant. Using genetic epistasis analysis, we show that dbl-1/TGF-β and daf-12/NHR steroid hormone signaling pathways are required for the daf-16/FOXO arrest-defective phenotype, suggesting that daf-16/FOXO represses dbl-1/TGF-β, daf-12/NHR and daf-36/oxygenase. The dbl-1/TGF-β and daf-12/NHR pathways have not previously been shown to affect L1 development, but we found that disruption of these pathways delayed L1 development in fed larvae, consistent with these pathways promoting development in starved daf-16/FOXO mutants. Though the dbl-1/TGF-β and daf-12/NHR pathways are epistatic to daf-16/FOXO for the arrest-defective phenotype, disruption of these pathways does not suppress starvation sensitivity of daf-16/FOXO mutants. This observation uncouples starvation survival from developmental arrest, indicating that DAF-16/FOXO targets distinct effectors for each phenotype and revealing that inappropriate development during starvation does not cause the early demise of daf-16/FOXO mutants. Overall, this study shows that daf-16/FOXO promotes developmental arrest cell-nonautonomously by repressing pathways that promote larval development.

Frequency and survival pattern of in-hospital cardiac arrests: The impacts of etiology and timing.

PubMed

Tran, Sheri; Deacon, Naomi; Minokadeh, Anushirvan; Malhotra, Atul; Davis, Daniel P; Villanueva, Sheri; Sell, Rebecca E

2016-10-01

Define the frequency and survival pattern of cardiac arrests in relation to the hospital day of event and etiology of arrest. Retrospective cohort study of adult in-hospital cardiac arrests between July 1, 2005, and June 30, 2013, that were classified by etiology of deterioration. Arrests were divided based on hospital day (HD) of event (HD1, HD2-7, HD>7 days), and analysis of frequency was performed. The primary outcome of survival to discharge and secondary outcomes of return of spontaneous circulation (ROSC) and favorable neurological outcomes were compared using multivariable logistic regression analysis. A total of 627 cases were included, 193 (30.8%) cases in group HD1, 206 (32.9%) in HD2-7, and 228 (36.4%) in HD>7. Etiology of arrest demonstrated variability across the groups (p<0.001). Arrests due to ventilation issues increased in frequency with longer hospitalization (p<0.001) while arrests due to dysrhythmia had the opposite trend (p=0.014). Rates of survival to discharge (p=0.038) and favorable neurological outcomes (p=0.002) were lower with increasing hospital days while ROSC was not different among the groups (p=0.183). Survival was highest for HD1 (HD1: 38.9% [95% CI, 32.0-45.7%], p=0.002 vs HD2-7: 34.0% [95% CI, 27.5-40.4%], p<0.001 vs HD>7: 27.2% [95% CI, 21.4-33.0%], p<0.001). The etiology of cardiac arrests varies in frequency as length of hospitalization increases. Survival rates and favorable neurological outcomes are lower for in-hospital arrests occurring later in the hospitalization, even when adjusted for age, sex, and location of event. Understanding these issues may help with focusing therapies and accurate prognostication. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Frequency and survival pattern of in-hospital cardiac arrests: The impacts of etiology and timing☆,☆☆,★

PubMed Central

Tran, Sheri; Deacon, Naomi; Minokadeh, Anushirvan; Malhotra, Atul; Davis, Daniel P.; Villanueva, Sheri; Sell, Rebecca E.

2017-01-01

Objective Define the frequency and survival pattern of cardiac arrests in relation to the hospital day of event and etiology of arrest. Subject and methods Retrospective cohort study of adult in-hospital cardiac arrests between July 1, 2005, and June 30, 2013, that were classified by etiology of deterioration. Arrests were divided based on hospital day (HD) of event (HD1, HD2–7, HD>7 days), and analysis of frequency was performed. The primary outcome of survival to discharge and secondary outcomes of return of spontaneous circulation (ROSC) and favorable neurological outcomes were compared using multivariable logistic regression analysis. Results A total of 627 cases were included, 193 (30.8%) cases in group HD1, 206 (32.9%) in HD2–7, and 228 (36.4%) in HD>7. Etiology of arrest demonstrated variability across the groups (p < 0.001). Arrests due to ventilation issues increased in frequency with longer hospitalization (p < 0.001) while arrests due to dysrhythmia had the opposite trend (p = 0.014). Rates of survival to discharge (p = 0.038) and favorable neurological outcomes (p = 0.002) were lower with increasing hospital days while ROSC was not different among the groups (p = 0.183). Survival was highest for HD1 (HD1: 38.9% [95% CI, 32.0–45.7%], p = 0.002 vs HD2–7: 34.0% [95% CI, 27.5–40.4%], p < 0.001 vs HD>7: 27.2% [95% CI, 21.4–33.0%], p < 0.001). Conclusions The etiology of cardiac arrests varies in frequency as length of hospitalization increases. Survival rates and favorable neurological outcomes are lower for in-hospital arrests occurring later in the hospitalization, even when adjusted for age, sex, and location of event. Understanding these issues may help with focusing therapies and accurate prognostication. PMID:27456394

Cardiac Arrest in Patients Managed for Convulsive Status Epilepticus: Characteristics, Predictors, and Outcome.

PubMed

Legriel, Stephane; Bresson, Edouard; Deye, Nicolas; Grimaldi, David; Sauneuf, Bertrand; Lesieur, Olivier; Lascarrou, Jean-Baptiste; Argaud, Laurent; Chelly, Jonathan; Beuret, Pascal; Schnell, David; Chateauneuf, Anne-Laure; Holleville, Mathilde; Perier, François; Lemiale, Virginie; Bruel, Cedric; Cronier, Pierrick; Pichon, Nicolas; Mongardon, Nicolas; de-Prost, Nicolas; Dumas, Florence; Cariou, Alain

2018-05-08

Cardiac arrest is a catastrophic event that may arise during the management of convulsive status epilepticus. We aimed to report the clinical characteristics, outcomes, and early predictors of convulsive status epilepticus-related cardiac arrest. Retrospective multicenter study. Seventeen university or university affiliated participating ICUs in France and Belgium. Consecutive patients admitted to the participating ICUs for management of successfully resuscitated out-of-hospital cardiac arrest complicating the initial management of convulsive status epilepticus between 2000 and 2015. Patients were compared with controls without cardiac arrest identified in a single-center registry of convulsive status epilepticus patients, regarding characteristics, management, and outcome. None. We included 49 cases with convulsive status epilepticus-cardiac arrest and 235 controls. In the cases, median time from medical team arrival to cardiac arrest was 25 minutes (interquartile range, 5-85 min). First recorded rhythm was asystole in 25 patients (51%) and pulseless electrical activity in 13 patients (27%). A significantly larger proportion of patients had a favorable 1-year outcome (Glasgow Outcome Scale score of 5) among controls (90/235; 38%) than among cases (10/49; 21%; p = 0.02). By multivariate analysis, independent predictors of cardiac arrest were pulse oximetry less than 97% on scene (odds ratio, 2.66; 95% CI, 1.03-7.26; p = 0.04), drug poisoning as the cause of convulsive status epilepticus (odds ratio, 4.13; 95% CI, 1.27-13.53; p = 0.02), and complications during early management (odds ratio, 11.98; 95% CI, 4.67-34.69; p < 0.0001). Having at least one comorbidity among cardiac, respiratory, and neurologic (other than epilepsy) conditions predicted absence of cardiac arrest (odds ratio, 0.28; 95% CI, 0.10-0.80; p = 0.02). In patients managed for convulsive status epilepticus, relative hypoxemia, on-scene management complications, and drug poisoning as the cause of convulsive status epilepticus were strong early predictors of cardiac arrest, suggesting areas for improvement.

Critical incident technique analysis applied to perianesthetic cardiac arrests at a university teaching hospital.

PubMed

Hofmeister, Erik H; Reed, Rachel A; Barletta, Michele; Shepard, Molly; Quandt, Jane

2018-05-01

To apply the critical incident technique (CIT) methodology to a series of perianesthetic cardiac arrest events at a university teaching hospital to describe the factors that contributed to cardiac arrest. CIT qualitative analysis of a case series. A group of 16 dogs and cats that suffered a perioperative cardiac arrest between November 2013 and November 2016. If an arrest occurred, the event was discussed among the anesthesiologists. The discussion included a description of the case, a description of the sequence of events leading up to the arrest and a discussion of what could have been done to affect the outcome. A written description of the case and the event including animal signalment and a timeline of events was provided by the supervising anesthesiologist following discussion among the anesthesiologists. Only dogs or cats were included. After the data collection period, information from the medical record was collected. A qualitative document analysis was performed on the summaries provided about each case by the supervising anesthesiologist, the medical record and any supporting documents. Each case was then classified into one or more of the following: animal, human, equipment, drug and procedural factors for cardiac arrest. The most common factor was animal (n=14), followed by human (n=12), procedural (n=4), drugs (n=1) and equipment (n=1). The majority (n=11) of animals had multiple factors identified. Cardiac arrests during anesthesia at a referral teaching hospital were primarily a result of animal and human factors. Arrests because of procedural, drug and equipment factors were uncommon. Most animals experienced more than one factor and two animals arrested after a change in recumbency. Future work should focus on root cause analysis and interventions designed to minimize all factors, particularly human ones. Copyright © 2018 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.

[Chronobiology of out-of-hospital cardiac arrest in Galicia with semi-automatic external defibrillators].

PubMed

Soto-Araujo, L; Costa-Parcero, M; López-Campos, M; Sánchez-Santos, L; Iglesias-Vázquez, J A; Rodríguez-Núñez, A

2015-04-01

To analyze the chronobiological variations of out-hospital cardiac arrest in which an automated external defibrillator was used in Galicia. Descriptive retrospective study of the cardiac arrest attended by the Emergency Medical Service in which an automated external defibrillator was in use during a period of 5 years (2007-2011). An Utstein style database was used. The sex, age, date and hour of the event, location, cardiac arrest attended, beginning of resuscitation by the professional, first monitored rhythm, emergency team activation time and care, endotracheal intubation, and recovery of spontaneous circulation were studied as independent variables. A total of 2,005 cases (0.14/1,000 population-year) was recorded. Time slot with more frequency of cardiac arrest: between 09-11 hrs (18.4%). Months with more cases: January (10.4%) and December (9.8%). It was significantly more probable that the cardiac arrest occurred in the home between 00-08 hrs, and in the street between 08-16 hrs. Asystole was more frequent in the night period (00-08 hrs), whereas the shockable rhythm was in the evening (16-00 hrs). There is more probability of death after cardiac arrest between 00-08 hrs, with recovery of spontaneous circulation being more probable between 16-00 hrs. The time between the emergency team activation and time care was longer in night schedule. In Galicia, cardiac arrest is more frequent in the winter months and in morning schedule. There is a circadian distribution of the cardiac arrest and the rhythm detected at the time of the first assistance, with asystole being more common in night schedule and the shockable rhythm in the evening. The chronobiology of the cardiac arrest should be taken into account in order to organize the distribution and the schedule of the healthcare resources. Copyright © 2013 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

Cardiac arrest due to lymphocytic colitis: a case report

PubMed Central

2012-01-01

Introduction We present a case of cardiac arrest due to hypokalemia caused by lymphocytic colitis. Case presentation A 69-year-old Caucasian man presented four months prior to a cardiac arrest with watery diarrhea and was diagnosed with lymphocytic colitis. Our patient experienced a witnessed cardiac arrest at his general practitioner's surgery. Two physicians and the emergency medical services resuscitated our patient for one hour and four minutes before arriving at our university hospital. Our patient was defibrillated 16 times due to the recurrence of ventricular tachyarrhythmias. An arterial blood sample revealed a potassium level of 2.0 mmol/L (reference range: 3.5 to 4.6 mmol/L) and pH 6.86 (reference range: pH 7.37 to 7.45). As the potassium level was corrected, the propensity for ventricular tachyarrhythmias ceased. Our patient recovered from his cardiac arrest without any neurological deficit. Further tests and examinations revealed no other reason for the cardiac arrest. Conclusion Diarrhea can cause life-threatening situations due to the excretion of potassium, ultimately causing cardiac arrest due to hypokalemia. Physicians treating patients with severe diarrhea should consider monitoring their electrolyte levels. PMID:22405093

The nature of the colloidal 'glass' transition.

PubMed

Dawson, Kenneth A; Lawlor, A; DeGregorio, Paolo; McCullagh, Gavin D; Zaccarelli, Emanuela; Foffi, Giuseppe; Tartaglia, Piero

2003-01-01

The dynamically arrested state of matter is discussed in the context of athermal systems, such as the hard sphere colloidal arrest. We believe that the singular dynamical behaviour near arrest expressed, for example, in how the diffusion constant vanishes may be 'universal', in a sense to be discussed in the paper. Based on this we argue the merits of studying the problem with simple lattice models. This, by analogy with the the critical point of the Ising model, should lead us to clarify the questions, and begin the program of establishing the degree of universality to be expected. We deal only with 'ideal' athermal dynamical arrest transitions, such as those found for hard sphere systems. However, it is argued that dynamically available volume (DAV) is the relevant order parameter of the transition, and that universal mechanisms may be well expressed in terms of DAV. For simple lattice models we give examples of simple laws that emerge near the dynamical arrest, emphasising the idea of a near-ideal gas of 'holes', interacting to give the power law diffusion constant scaling near the arrest. We also seek to open the discussion of the possibility of an underlying weak coupling theory of the dynamical arrest transition, based on DAV.

Arrest scenarios in concentrated protein solutions - from hard sphere glasses to arrested spinodal decomposition

NASA Astrophysics Data System (ADS)

Stradner, Anna; Bucciarelli, Saskia; Casal, Lucia; Foffi, Giuseppe; Thurston, George; Farago, Bela; Schurtenberger, Peter

2014-03-01

The occurrence of an arrest transition in concentrated colloid suspensions and its dependence on the interaction potential is a hot topic in soft matter. Such arrest transitions can also occur in concentrated protein solutions, as they exist e.g. in biological cells or are increasingly used in pharmaceutical formulations. Here we demonstrate the applicability of concepts from colloid science to understand the dynamics of concentrated protein solutions. In this presentation we report a combination of 3D light scattering, small-angle X-ray scattering and neutron spin echo measurements to study the structural properties as well as the collective and self diffusion of proteins in highly concentrated solutions on the relevant length and time scales. We demonstrate that various arrest scenarios indeed exist for different globular proteins. The proteins chosen are different bovine lens crystallins. We report examples of hard and attractive glass transitions and arrested spinodal decomposition directly linked to the effective pair potentials determined in static scattering experiments for the different proteins. We discuss these different arrest scenarios in view of possible applications of dense protein solutions as well as in view of their possible relevance for living systems.

The Development of French Nuclear Forces

DTIC Science & Technology

1987-11-01

4.1 a rc I -MM RON -- .’-.U . . tn L) L- _*z T M - N EppCV :c 4:-ea THE DEVELOPMENT OF FRENCH NUCLEAR FORCES SMEEC TEV46 P 1 9 1988 Martin J. Wisda...TABLES 1. Transformation of the French Nuclear Force ..... . 100 2. Characteristics of French Nucleac Weapons . . .. 01 3. French Defense Expenditures...pap-er is to examine how and why the French undertook the development of their own nuclear force and through this examination, argue that the French

SU-A-210-01: Why Should We Learn Radiation Oncology Billing?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, H.

The purpose of this student annual meeting is to address topics that are becoming more relevant to medical physicists, but are not frequently addressed, especially for students and trainees just entering the field. The talk is divided into two parts: medical billing and regulations. Hsinshun Wu – Why should we learn radiation oncology billing? Many medical physicists do not like to be involved with medical billing or coding during their career. They believe billing is not their responsibility and sometimes they even refuse to participate in the billing process if given the chance. This presentation will talk about a physicist’smore » long career and share his own experience that knowing medical billing is not only important and necessary for every young medical physicist, but that good billing knowledge could provide a valuable contribution to his/her medical physics development. Learning Objectives: The audience will learn the basic definition of Current Procedural Terminology (CPT) codes performed in a Radiation Oncology Department. Understand the differences between hospital coding and physician-based or freestanding coding. Apply proper CPT coding for each Radiation Oncology procedure. Each procedure with its specific CPT code will be discussed in detail. The talk will focus on the process of care and use of actual workflow to understand each CPT code. Example coding of a typical Radiation Oncology procedure. Special procedure coding such as brachytherapy, proton therapy, radiosurgery, and SBRT. Maryann Abogunde – Medical physics opportunities at the Nuclear Regulatory Commission (NRC) The NRC’s responsibilities include the regulation of medical uses of byproduct (radioactive) materials and oversight of medical use end-users (licensees) through a combination of regulatory requirements, licensing, safety oversight including inspection and enforcement, operational experience evaluation, and regulatory support activities. This presentation will explore the career options for medical physicists in the NRC, how the NRC interacts with clinical medical physicists, and a physicist’s experience as a regulator. Learning Objectives: Explore non-clinical career pathways for medical physics students and trainees at the Nuclear Regulatory Commission. Overview of NRC medical applications and medical use regulations. Understand the skills needed for physicists as regulators. Abogunde is funded to attend the meeting by her employer, the NRC.« less

SU-A-210-02: Medical Physics Opportunities at the NRC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abogunde, M.

The purpose of this student annual meeting is to address topics that are becoming more relevant to medical physicists, but are not frequently addressed, especially for students and trainees just entering the field. The talk is divided into two parts: medical billing and regulations. Hsinshun Wu – Why should we learn radiation oncology billing? Many medical physicists do not like to be involved with medical billing or coding during their career. They believe billing is not their responsibility and sometimes they even refuse to participate in the billing process if given the chance. This presentation will talk about a physicist’smore » long career and share his own experience that knowing medical billing is not only important and necessary for every young medical physicist, but that good billing knowledge could provide a valuable contribution to his/her medical physics development. Learning Objectives: The audience will learn the basic definition of Current Procedural Terminology (CPT) codes performed in a Radiation Oncology Department. Understand the differences between hospital coding and physician-based or freestanding coding. Apply proper CPT coding for each Radiation Oncology procedure. Each procedure with its specific CPT code will be discussed in detail. The talk will focus on the process of care and use of actual workflow to understand each CPT code. Example coding of a typical Radiation Oncology procedure. Special procedure coding such as brachytherapy, proton therapy, radiosurgery, and SBRT. Maryann Abogunde – Medical physics opportunities at the Nuclear Regulatory Commission (NRC) The NRC’s responsibilities include the regulation of medical uses of byproduct (radioactive) materials and oversight of medical use end-users (licensees) through a combination of regulatory requirements, licensing, safety oversight including inspection and enforcement, operational experience evaluation, and regulatory support activities. This presentation will explore the career options for medical physicists in the NRC, how the NRC interacts with clinical medical physicists, and a physicist’s experience as a regulator. Learning Objectives: Explore non-clinical career pathways for medical physics students and trainees at the Nuclear Regulatory Commission. Overview of NRC medical applications and medical use regulations. Understand the skills needed for physicists as regulators. Abogunde is funded to attend the meeting by her employer, the NRC.« less

SU-A-210-00: AAPM Medical Physics Student Meeting: Medical Billing and Regulations: Everything You Always Wanted To Know, But Were Too Afraid To Ask

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The purpose of this student annual meeting is to address topics that are becoming more relevant to medical physicists, but are not frequently addressed, especially for students and trainees just entering the field. The talk is divided into two parts: medical billing and regulations. Hsinshun Wu – Why should we learn radiation oncology billing? Many medical physicists do not like to be involved with medical billing or coding during their career. They believe billing is not their responsibility and sometimes they even refuse to participate in the billing process if given the chance. This presentation will talk about a physicist’smore » long career and share his own experience that knowing medical billing is not only important and necessary for every young medical physicist, but that good billing knowledge could provide a valuable contribution to his/her medical physics development. Learning Objectives: The audience will learn the basic definition of Current Procedural Terminology (CPT) codes performed in a Radiation Oncology Department. Understand the differences between hospital coding and physician-based or freestanding coding. Apply proper CPT coding for each Radiation Oncology procedure. Each procedure with its specific CPT code will be discussed in detail. The talk will focus on the process of care and use of actual workflow to understand each CPT code. Example coding of a typical Radiation Oncology procedure. Special procedure coding such as brachytherapy, proton therapy, radiosurgery, and SBRT. Maryann Abogunde – Medical physics opportunities at the Nuclear Regulatory Commission (NRC) The NRC’s responsibilities include the regulation of medical uses of byproduct (radioactive) materials and oversight of medical use end-users (licensees) through a combination of regulatory requirements, licensing, safety oversight including inspection and enforcement, operational experience evaluation, and regulatory support activities. This presentation will explore the career options for medical physicists in the NRC, how the NRC interacts with clinical medical physicists, and a physicist’s experience as a regulator. Learning Objectives: Explore non-clinical career pathways for medical physics students and trainees at the Nuclear Regulatory Commission. Overview of NRC medical applications and medical use regulations. Understand the skills needed for physicists as regulators. Abogunde is funded to attend the meeting by her employer, the NRC.« less