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Sample records for french intermede study

  1. French Studies: A Bibliography.

    ERIC Educational Resources Information Center

    Markey, William L., Comp.

    A bibliography of materials relating to French language and area studies includes citations of bibliographies, books, articles, and general and specialized reference materials in French and English in these categories: general reference guides; guides to French studies; style manuals; research methodology and handbooks; library resources;…

  2. Ethnobotany in Intermedical Spaces: The Case of the Fulni-ô Indians (Northeastern Brazil)

    PubMed Central

    Soldati, Gustavo Taboada; Paulino de Albuquerque, Ulysses

    2012-01-01

    We analyzed the Fulni-ô medical system and introduced its intermedical character based on secondary data published in the literature. Then we focused on the medicinal plants known to the ethnic group, describing the most important species, their therapeutic uses and the body systems attributed to them. We based this analysis on the field experience of the authors in the project Studies for the Environmental and Cultural Sustainability of the Fulni-ô Medical System: Office of Medicinal Plant Care. This traditional botanical knowledge was used to corroborate the hybrid nature of local practices for access to health. We show that intermedicality is a result not only of the meeting of the Fulni-ô medical system with Biomedicine but also of its meeting with other traditional systems. Finally, we discuss how traditional botanical knowledge may be directly related to the ethnogenesis process led by the Fulni-ô Indians in northeastern Brazil. PMID:21961025

  3. Stimulating Student Interest in Physiology: The Intermedical School Physiology Quiz

    ERIC Educational Resources Information Center

    Cheng, Hwee-Ming

    2010-01-01

    The Intermedical School Physiology Quiz (IMSPQ) was initiated in 2003 during the author's last sabbatical from the University of Malaya. At this inaugural event, there were just seven competing teams from Malaysian medical schools. The challenge trophy for the IMSPQ is named in honor of Prof. A. Raman, who was the first Malaysian Professor of…

  4. Why Study French?

    ERIC Educational Resources Information Center

    Bunge, Gerard

    This brochure for parents and prospective students of French points out career opportunities available to qualified speakers of French. Suggestions concerning student eligibility and the time requirements of language programs are also offered. (RL)

  5. A Film Study Option for HSC French

    ERIC Educational Resources Information Center

    Connole, Pat

    1974-01-01

    In 1974, after a trial period of two years, the study of two selected French feature films will be offered as an option to the study of prescribed texts in Higher School Certificate French in Victoria. (Author)

  6. Misconceptions Highlighted among Medical Students in the Annual International Intermedical School Physiology Quiz

    ERIC Educational Resources Information Center

    Cheng, Hwee-Ming; Durairajanayagam, Damayanthi

    2012-01-01

    The annual Intermedical School Physiology Quiz (IMSPQ), initiated in 2003, is now an event that attracts a unique, large gathering of selected medical students from medical schools across the globe. The 8th IMSPQ, in 2010, hosted by the Department of Physiology, University of Malaya, in Kuala Lumpur, Malaysia, had 200 students representing 41…

  7. Study Guide for TCT in French.

    ERIC Educational Resources Information Center

    Brooks, J. Carroll; Bradley, C. Lee

    This study guide is specifically designed for those individuals preparing to take the Georgia Teacher Certification Test (TCT) in French language instruction. It covers four areas: (1) grammar; (2) usage; (3) history, geography, and literature; and (4) listening and oral skills. This guide provides prospective examinees with test content…

  8. Hierarchies of Authenticity in Study Abroad: French from Canada versus French from France?

    ERIC Educational Resources Information Center

    Wernicke, Meike

    2016-01-01

    For many decades, Francophone regions in Canada have provided language study exchanges for French as a second language (FSL) learners within their own country. At the same time, FSL students and teachers in Canada continue to orient to a native speaker standard associated with European French. This Eurocentric orientation manifested itself in a…

  9. A Modern Curriculum in French Studies.

    ERIC Educational Resources Information Center

    Nelson, Robert J.

    The French department, commonly viewed by chairmen and faculty as the conveyor of culture, is admonished to revamp its curriculum and attempt to embrace a broader, more humane understanding of the nature of culture. With the traditional, belletristic, college French curriculum having been rejected in favor of programs based on "cogency, cohesion,…

  10. Studies in French Grammar and Phonology.

    ERIC Educational Resources Information Center

    Benguerel, Andre-Pierre; Grundstrom, Allan W.

    The monograph contains two papers. The first presents a generative grammar for verbal forms in French. It consists of an ordered set of rewrite rules and a set of tables. It generates all existing verbal forms without generating any non-existing ones. The departure from an ordinary generative grammar lies in the use of a tabular form for…

  11. French Immersion Teacher Education: A Study of Two Programs.

    ERIC Educational Resources Information Center

    Day, Elaine M.; Shapson, Stan M.

    1993-01-01

    A study of French immersion teacher education programs at Simon Fraser University and Faculte Saint-Jean (University of Alberta) in Canada is reported. The in-depth case studies examined program clientele, models, participant experiences and needs, and planning, especially in relation to current research on teacher education. (Author/MSE)

  12. For a Study of Diglossia in French Canada.

    ERIC Educational Resources Information Center

    Spilka, Irene V.

    This paper defines diglossia as "a situation in which two closely related language systems enjoy differing social status, one being the 'high' and the other the 'low' language," and then attempts to show how a study of diglossia in Canada, where such a diglossic situation is seen to exist among varieties of French, might be carried out.…

  13. French contribution to ozone related studies

    NASA Astrophysics Data System (ADS)

    Megie, G.

    Experiments conducted in France to study the tropospheric and stratospheric ozone layer and the minor constituents which are of interest in the prediction of natural and anthropogenic climatic effects are reviewed. With reference to ground-based measurements, consideration is given to continuous ozone monitoring using Dobson instruments, lidar measurements of atmospheric constituents, IR spectroscopy, monitoring of the troposphere pollution level by gas chromatography, measurements of the atmospheric turbulent layers by star scintillation, and microwave measurements of ozone and minor constituents. Airborne measurements include two Spacelab experiments: measurement of stratospheric trace constituents using a grid spectrometer, and solar spectrum and solar constant observations by UV spectrometry. Laboratory experiments and theoretical models are also discussed.

  14. Disciplinary and Research Subjects in French Doctoral Dissertations in Press and Media Studies: A Bibliometric Treatment

    ERIC Educational Resources Information Center

    Herubel, Jean-Pierre V. M.

    2007-01-01

    For English-speaking researchers, French doctoral dissertations can represent a "terra incognita." For this reason, a retrospective bibliometric study of French dissertations in press and media studies offers a useful profile of available research to researchers concentrating in studies of the press and other media. The present study…

  15. Subject-Verb Agreement, Object Clitics and Wh-Questions in Bilingual French-Greek SLI: The Case Study of a French-Greek-Speaking Child with SLI

    ERIC Educational Resources Information Center

    Stavrakaki, Stavroula; Chrysomallis, Marie-Annick; Petraki, Evangelia

    2011-01-01

    In this study we investigate the linguistic performance of a school age French-Greek simultaneous bilingual boy with specific language impairment (SLI) on the production of subject-verb agreement, object clitic pronouns and wh-questions. In addition, we compare his performance on these linguistic structures with that of two French-Greek bilingual…

  16. Euphemism as a Core Feature of "Patientese": A Comparative Study between English and French

    ERIC Educational Resources Information Center

    Faure, Pascaline

    2016-01-01

    The purpose of this lexicological study is to present a typology of patients' euphemizing lay denominations of medical terms illustrated by examples in English and French. Various textbooks and lexicons dealing with English and French for medical purposes served as corpora. The euphemisms were classified according to the three semantic processes…

  17. Franco-American Ethnic Heritage Studies Program. Contributions of the French to America: Dissemination of Materials.

    ERIC Educational Resources Information Center

    Chasse, Paul P.

    The document contains 12 units suitable for use in junior and senior high school social studies classes on experiences and acculturation of first and second generation French people in the Northeastern United States. Each unit is presented in both the English and French language. Units are entitled "Education,""The…

  18. The French Defense and Foreign Policies: Rwanda Case Study

    DTIC Science & Technology

    2013-03-25

    France learnt this lesson harshly in Rwanda in 1994 . Indeed, in the wave of the genocide , accusations not only arose against France and senior...critics to the French policy in Rwanda during the genocide in 1994 . First, the 1983 revision permitted the French military to be involved in combat and... genocide . In 1994 in Rwanda , France learned harsh lessons and lost some of its credibility in Africa and among its allies. Since then, important

  19. Emergency Care for Homeless Patients: A French Multicenter Cohort Study

    PubMed Central

    Feral-Pierssens, Anne-Laure; Aubry, Adeline; Truchot, Jennifer; Raynal, Pierre-Alexis; Boiffier, Mathieu; Hutin, Alice; Leleu, Agathe; Debruyne, Geraud; Joly, Luc-Marie; Juvin, Philippe; Riou, Bruno

    2016-01-01

    Objectives. To determine whether homeless patients experience suboptimal care in the emergency department (ED) by the provision of fewer health care resources. Methods. We conducted a prospective multicenter cohort study in 30 EDs in France. During 72 hours in March 2015, all homeless patients that visited the participating EDs were included in the study. The primary health care service measure was the order by the physician of a diagnostic investigation or provision of a treatment in the ED. Secondary measures of health care services included ED waiting time, number and type of investigations per patient, treatment in the ED, and discharge disposition. Results. A total of 254 homeless patients and 254 nonhomeless patients were included. After excluding homeless patients that attended the ED for the sole purpose of housing, we analyzed 214 homeless and 214 nonhomeless. We found no significant difference between the 2 groups in terms of health care resource consumption, and for our secondary endpoints. Conclusions. We did not find significant differences in the level of medical care delivered in French EDs to homeless patients compared with matched nonhomeless patients. PMID:26985613

  20. Redesigning a Participatory Health Study for a French Industrial Context.

    PubMed

    Allen, Barbara L; Cohen, Alison K; Ferrier, Yolaine; Lees, Johanna; Richards, Travis

    2016-08-21

    The Marseille, France, metropolitan area is home to a heavily concentrated industrial region directly adjacent to residential communities. These towns have been subjected to a wide variety of social science and public health studies, but residents continue to have many questions about health concerns for which they currently have primarily anecdotal evidence. Reflecting on our in-progress research in two of these towns, we argue that community-based participatory research that draws from both social science and public health science can be successfully adapted to the French political and cultural context and is key for developing environmental health research that is relevant for community residents and local leaders. Understanding and working within the customs of the local values and practices culture is critical for community-based participatory research regardless of location but is particularly paramount when working in non-United States contexts, since local values and practices will shape the particular techniques used within the community-based participatory research framework.

  1. French Teaching Aids.

    ERIC Educational Resources Information Center

    Miller, J. Dale

    Supplementary teaching materials for French language programs are presented in this text. Primarily intended for secondary school students, the study contains seven units of material. They include: (1) French gestures, (2) teaching the interrogative pronouns, (3) French cuisine, (4) recreational learning games, (5) French-English cognates, (6)…

  2. Urinary arsenic levels in the French adult population: the French National Nutrition and Health Study, 2006-2007.

    PubMed

    Saoudi, Abdessattar; Zeghnoun, Abdelkrim; Bidondo, Marie-Laure; Garnier, Robert; Cirimele, Vincent; Persoons, Renaud; Fréry, Nadine

    2012-09-01

    The French Nutrition and Health Survey (ENNS) was conducted to describe dietary intakes, nutritional status, physical activity, and levels of various biomarkers for environmental chemicals (heavy metals and pesticides) in the French population (adults aged 18-74 years and children aged 3-17 years living in continental France in 2006-2007). The aim of this paper was to describe the distributions of total arsenic and the sum of iAs+MMA+DMA in the general adult population, and to present their main risk factors. In the arsenic study, 1500 and 1515 adults (requested to avoid seafood intake in the previous 3 days preceding urine collection) were included respectively for the analysis of the sum of inorganic arsenic (iAs) and its two metabolites, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and for the total arsenic. Results were presented as geometric means and selected percentiles of urinary arsenic concentrations (μg/L) and creatinine-adjusted urinary arsenic (μg/g of creatinine) for total arsenic, and the sum of inorganic arsenic and metabolites (iAs+MMA+DMA). The geometric mean concentration of the sum of iAs+MMA+DMA in the adult population living in France was 3.34 μg/g of creatinine [3.23-3.45] (3.75 μg/L [3.61-3.90]) with a 95th percentile of 8.9 μg/g of creatinine (10.68 μg/L). The geometric mean concentration of total arsenic was 11.96 μg/g of creatinine [11.41-12.53] (13.42 μg/L [12.77-14.09]) with a 95th percentile of 61.29 μg/g of creatinine (72.75 μg/L). Urinary concentrations of total arsenic and iAS+MMA+DMA were influenced by sociodemographic and economic factors, and by risk factors such as consumption of seafood products and of wine. In our study, covariate-adjusted geometric means demonstrated several slight differences, due to consumption of fish, shellfish/crustaceans or wine. This study provides the first reference value for arsenic in a representative sample of the French population not particularly exposed to high levels

  3. Subject-verb agreement, object clitics and wh-questions in bilingual French-Greek SLI: the case study of a French-Greek-speaking child with SLI.

    PubMed

    Stavrakaki, Stavroula; Chrysomallis, Marie-Annick; Petraki, Evangelia

    2011-05-01

    In this study we investigate the linguistic performance of a school age French-Greek simultaneous bilingual boy with specific language impairment (SLI) on the production of subject-verb agreement, object clitic pronouns and wh-questions. In addition, we compare his performance on these linguistic structures with that of two French-Greek bilingual children with typical development matched on language age. Furthermore, we discuss the performance of the child with SLI in the light of published data from monolingual French and Greek school-age children with SLI, as reported in the relevant literature. The results indicated that the performance of the bilingual French-Greek-speaking child with SLI was highly comparable to that of bilingual French-Greek typically developing children and monolingual children with SLI speaking French or Greek. In addition, the results revealed a language effect on the performance of the bilingual child with SLI on subject-verb agreement, object clitics and wh-questions. We adopt a comparative linguistic approach to interpret the results and argue that the specific linguistic properties of Greek and French were significant determinants for the manifestation of SLI in each language. We suggest that bilingualism per se did not aggravate the language deficits in this child with SLI. Finally, we discuss the clinical implications of our study for language intervention in bilingual individuals with SLI.

  4. Car Crashes and Central Disorders of Hypersomnolence: A French Study

    PubMed Central

    Lopez, Regis; Pesenti, Carole; Plazzi, Giuseppe; Drouot, Xavier; Leu-Semenescu, Smaranda; Beziat, Severine; Arnulf, Isabelle; Dauvilliers, Yves

    2015-01-01

    Background Drowsiness compromises driving ability by reducing alertness and attentiveness, and delayed reaction times. Sleep-related car crashes account for a considerable proportion of accident at the wheel. Narcolepsy type 1 (NT1), narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) are rare central disorders of hypersomnolence, the most severe causes of sleepiness thus being potential dangerous conditions for both personal and public safety with increasing scientific, social, and political attention. Our main objective was to assess the frequency of recent car crashes in a large cohort of patients affected with well-defined central disorders of hypersomnolence versus subjects from the general population. Methods We performed a cross-sectional study in French reference centres for rare hypersomnia diseases and included 527 patients and 781 healthy subjects. All participants included needed to have a driving license, information available on potential accident events during the last 5 years, and on potential confounders; thus analyses were performed on 282 cases (71 IH, 82 NT2, 129 NT1) and 470 healthy subjects. Results Patients reported more frequently than healthy subjects the occurrence of recent car crashes (in the previous five years), a risk that was confirmed in both treated and untreated subjects at study inclusion (Untreated, OR = 2.21 95%CI = [1.30–3.76], Treated OR = 2.04 95%CI = [1.26–3.30]), as well as in all disease categories, and was modulated by subjective sleepiness level (Epworth scale and naps). Conversely, the risk of car accidents of patients treated for at least 5 years was not different to healthy subjects (OR = 1.23 95%CI = [0.56–2.69]). Main risk factors were analogous in patients and healthy subjects. Conclusion Patients affected with central disorders of hypersomnolence had increased risk of recent car crashes compared to subjects from the general population, a finding potentially reversed by long-term treatment. PMID:26052938

  5. Linguistic Effects of Globalization: A Case Study of French for Specific Purposes (FSP) in Kenyan Vocational Schools

    ERIC Educational Resources Information Center

    Mulenda, Mubalama

    2013-01-01

    The study of French for Specific Purposes (FSP) is a topical subject in this era of globalization. Kenya requires people who can communicate in French in the various specialized areas. It has become crucial in Kenya to respond to the French language needs of students learning tourism and hospitality among other domains which have already shown an…

  6. [French validation study of the levels of emotional awareness scale].

    PubMed

    Bydlowski, S; Corcos, M; Paterniti, S; Guilbaud, O; Jeammet, P; Consoli, S M

    2002-01-01

    According to a thesis based on the idea of an influence of cognitions in the structuring of internal reality, emotional awareness, ie the capacity of representing your own emotional experience and that of others, is a cognitive process that goes into maturation. Defining this concept, Lane and Schwartz present a cognitivo-developmental model in five stages of the processes of symbolization, accounting for the differences in levels of emotional awareness observed in individuals. The organization of these cognitive processes would thus be structured in well differentiated stages, in which the development of the emotions would be inseparable from the development of ego and of the relation to others. These authors focus on the capacity of representing in a conscious way the emotional experience and consider that verbal representations used to describe the contents of what is experience constitute a good reflection of the organization structural of the emotional awareness. Therefore, they worked out an instrument of evaluation: the Levels of Emotional Awareness Scale (LEAS), which measures the capacity to describe your own emotional experience and the one you allow to others, in an emotional situation. The system of quotation of this scale is based on the analysis of the verbal contents of the provided answers, in direct reference to the authors' theory of the levels of differentiation and integration of the emotional experience. It is therefore an empirical measurement which is centered specifically on the structural organization of the emotional experience. The various studies of validation of this instrument show that it presents solid metrological properties. This work presents the validation of the French version of Lane and Schwartz's LEAS. Validity and fidelity were studied in a group of 121 healthy subjects. This setting is part of a larger clinical evaluation, also including a collection of socio-demographic and clinical data, and other instruments of self

  7. To which chemical mixtures is the French population exposed? Mixture identification from the second French Total Diet Study.

    PubMed

    Traoré, T; Béchaux, C; Sirot, V; Crépet, A

    2016-12-01

    Through their diet, humans are exposed to a wide range of substances with possible adverse effects. Total diet studies (TDS) assess exposure and risk for many single substances or mixtures from the same chemical family. This research aims to identify from 440 substances in the second French TDS, the major mixtures to which the French population is exposed and their associated diet. Firstly, substances with a contamination value over the detection limit were selected. Secondly, consumption systems comprising major consumed foods were identified using non-negative matrix factorisation and combined with concentration levels to form the main mixture. Thirdly, individuals were clustered to identify "diet clusters" with similar consumption patterns and co-exposure profiles. Six main consumption systems and their associated mixtures were identified. For example, a mixture of ten pesticides, six trace elements and bisphenol A was identified. Exposure to this mixture is related to fruit and vegetables consumed by a diet cluster comprising 62% of women with a mean age of 51 years. Six other clusters are described with their associated diets and mixtures. Cluster co-exposures were compared to the whole population. This work helps prioritise mixtures for which it is crucial to investigate possible toxicological effects.

  8. Vocational identity and psychological adjustment: a study in French adolescents and emerging adults.

    PubMed

    Lannegrand-Willems, Lyda; Perchec, Cyrille; Marchal, Clotilde

    2016-02-01

    The aim of the present research was to study vocational identity in French adolescent and emerging adult students by using a French adaptation of the Vocational Identity Status Assessment (VISA), and to analyze the links between vocational identity formation and negative and positive psychological adjustment. Participants were 1077 French students who completed self-report scales about vocational identity, depression and satisfaction with life. The French version of the VISA showed good psychometric properties and six identity statuses were derived by means of cluster analysis: achievement, foreclosure, moratorium, searching moratorium, diffused diffusion and carefree diffusion. The main findings show that diffused diffusion and moratorium represent the dark sides of identity because of their negative psychological adjustment, and that the two processes of reconsideration of commitment were differently associated with psychological adjustment. These findings demonstrate that clinical interventions should be adapted to the individual's identity profile.

  9. Seismic ambient noise study at Bouillante geothermal system, French Antilles

    NASA Astrophysics Data System (ADS)

    Jousset, Philippe; Bitri, Adnan; Loiseau, Justine; Bouchot, Vincent

    2010-05-01

    Seismic ambient noise analyses have been shown to be able to image structural features of the crust and to monitor underground changes of seismic wave ground velocity. We present results of cross-correlation techniques at Bouillante geothermal field, French Antilles, the largest French high-enthalpy geothermal system exploited for electrical power from 3 collocated productive wells. Two power plants generate electricity and fluid extraction rate varies with time and wells are sometimes closed for equipment maintenance. Under the support of the French Environment and Energy Management Agency (ADEME) and the French Research Agency (ANR), BRGM has been analyzing seismic data from a network comprising 5 broadband seismological stations set-up at Bouillante area since 2004. Amongst the large number of earthquakes recorded, we show that no single earthquake could be related to the fluid exploitation. Instead, they are due to the intense regional seismicity. Despite the small number of stations, surface wave travel times computed from ambient noise cross-correlation for about a year suggest that the velocity structure is consistent with the conceptual model of hot (250°C) and permeable (fractured) geothermal reservoir of Bouillante. We show at several instances that changes of the fluid extraction rate have spatial and temporal slight perturbations on medium wave velocity. For example, when the production stops for maintenance, velocity increases by several percent and with larger amplitude at stations within 1 km distance from the production wells and lower amplitudes (by more than 50 %) at stations further than 2 km from the production wells. In addition, we note that velocity perturbations have a delay of at most 1 day at further stations. We discuss several mechanisms to explain those observations like pressure and stress variations in the geothermal system. The results suggest that the inferred velocity changes, owing the fine sensibility of the inter

  10. Highlights of recent studies and future plans for the French human biomonitoring (HBM) programme.

    PubMed

    Fréry, Nadine; Vandentorren, Stéphanie; Etchevers, Anne; Fillol, Clémence

    2012-02-01

    This manuscript presents highlights of recent studies and perspectives from the French human biomonitoring (HBM) programme. Until recently, HBM studies focused on specific populations or pollutants to gain a better understanding of exposure to environmental chemicals, to help regulators reduce environmental exposure and to monitor existing policies on specific concerns. Highlights of recent multicentre biomonitoring studies with specific population or pollutant focus are given. These French HBM studies have been implemented to know: (1) the influence of living near an incinerator on serum dioxin and polychlorinated biphenyl (PCB) levels, (2) the influence of consuming river fish contaminated by PCBs on serum PCBs of fishermen, and (3) the evolution of blood lead levels in children from 1 to 6 years old since 1995. Special emphasis is placed on the use of an integrated (HBM coupled with nutrition and health studies), multipollutant approach. This approach has been initiated in France with a recent national population-based biomonitoring survey, the Etude Nationale Nutrition Santé (ENNS; French Nutrition and Health Survey). This survey will provide the first reference distribution for 42 biomarkers in the French population. The current national HBM strategy will build upon the ENNS and include a national survey of people aged between 6 and 74 years complemented for the neonatal period and childhood by the Etude Longitudinale Française depuis l'Enfance (ELFE; French longitudinal study of children). France also contributes to the harmonization of HBM activities in Europe through participation in European HBM projects.

  11. Gender stereotyping in television advertisements: a study of French and Danish television.

    PubMed

    Furnham, A; Babitzkow, M; Uguccioni, S

    2000-02-01

    Two similar, but not identical, content analyses of the portrayals of men and women in French and Danish television advertisements are reported. By partially replicating and extending past investigations conducted in America, Australia, Britain, Hong Kong, Indonesia, Italy, Kenya, and New Zealand, it was predicted that there would be more gender stereotyping in French television advertisements and less gender stereotyping in Danish television advertisements. In the first study, 165 French television advertisements were analyzed by following established coding categories (A. Furnham & E. Skae, 1997; L. Z. McArthur & B. G. Resko, 1975). Contrary to prediction, the results showed that traditional gender role portrayal on French television was no different from that found in other countries. Separate statistical analyses were carried out for visually versus aurally classified central figures, yet this yielded relatively few significant differences. In the second study, a sample of 151 Danish advertisements was analyzed; results showed that Danish television was generally less gender stereotypic than French television in its portrayal of women. Exactly half (5) of the coding categories showed significant differences. Finally, an international statistical comparison between these two studies and similar research in Australia, Britain, and Italy was carried out. The methodological implications of these results are discussed as well as the theoretical issues arising from other studies of this sort.

  12. Language Learning Strategies Used by Adolescents Studying French in New York Schools.

    ERIC Educational Resources Information Center

    Ramirez, Arnulfo G.

    1986-01-01

    Describes a study which attempted to determine the successful strategies utilized by adolescent learners studying French. The learning strategies investigated include: (1) classroom behaviors, (2) individual study tactics, and (3) social interaction behaviors. These strategies are examined in relation to their significance on different language…

  13. Spoken French: Book One.

    ERIC Educational Resources Information Center

    Denoeu, Francois; Hall, R. A., Jr.

    This textbook offers a course in French designed for those who need to make themselves understood on ordinary topics in French and cannot devote years of study to the language. It is a self-instructional course, but it is designed to be used with a native French speaker as a guide or, if no native speaker is available, with recordings that are…

  14. The French Version of the Modified-Checklist for Autism in Toddlers (M-CHAT): A Validation Study on a French Sample of 24 Month-Old Children

    ERIC Educational Resources Information Center

    Baduel, Sophie; Guillon, Quentin; Afzali, Mohammad H.; Foudon, Nadège; Kruck, Jeanne; Rogé, Bernadette

    2017-01-01

    Early ASD screening has the potential to reduce delays between initial parental concerns and diagnosis, and promote early intervention. The aim of this study was to validate the M-CHAT on a French population sample of 24 month-old children. This study included a low-risk sample of 1,227 children. A total of 20 children screened positive on the…

  15. Motivations and the Intent to Study Abroad among U.S., French, and Chinese Students

    ERIC Educational Resources Information Center

    Sanchez, Carol M.; Fornerino, Marianela; Zhang, Mengxia

    2006-01-01

    This paper analyzes the relationship between students' motivations and their intention to participate in study abroad programs using a model based on expectancy theory. We surveyed U.S., Chinese and French business students who studied in their home countries. Results suggest that certain motivations are common among students from the three…

  16. Electronic Mail, a New Written-Language Register: A Study with French-Speaking Adolescents

    ERIC Educational Resources Information Center

    Volckaert-Legrier, Olga; Bernicot, Josie; Bert-Erboul, Alain

    2009-01-01

    The aim of this study was to determine the extent to which the linguistic forms used by adolescents in electronic mail (e-mail) differ from those used in standard written language. The study was conducted in French, a language with a deep orthography that has strict, addressee-dependent rules for using second person personal pronouns (unfamiliar…

  17. Cardiac bioassist: results of the French multicenter cardiomyoplasty study.

    PubMed

    Chachques, Juan C; Jegaden, Olivier; Mesana, Thierry; Glock, Yves; Grandjean, Pierre A; Carpentier, Alain F

    2009-12-01

    The French multicenter experience (6 centers) of dynamic cardiomyoplasty was analyzed for long-term survival and functional outcome, the most important endpoints in congestive heart failure therapy. Cardiomyoplasty was performed in 212 patients with symptoms of chronic heart failure despite maximal pharmacological therapy. The etiology was ischemic (48%), idiopathic (45%) or other (7%). Cardiomyoplasty was performed using the latissimus dorsi muscle which was electrostimulated after surgery. During follow-up, 88% of patients improved clinically. Hospital death occurred in 29 (14%) patients and was related to the severity of preoperative heart failure symptoms. Late mortality occurred in 99 patients due to heart failure (44%), sudden death (37%), or noncardiac causes (18%). Combined dynamic cardiomyoplasty and implantation of a cardiac rhythm management system was safely achieved in 22 patients, and 26 underwent heart transplantation for recurrent heart failure. Long-term functional improvements were observed in most patients, and the best outcome was achieved in those with isolated right ventricular failure. Dynamic cardiomyoplasty can be considered as a destination therapy or a mid- to long-term biological bridge to heart transplantation.

  18. [Complications of transluminal coronary angioplasty. A multicenter French study (1983)].

    PubMed

    Valeix, B; Labrunie, P; Marco, J; Cherrier, F; Cuillière, M; Bertrand, M; Schmitt, R; Sabatier, M; Gaspard, P; Guermonprez, J L

    1985-03-01

    The authors report the complications observed during 1 247 transluminal coronary angioplasties (TCA) performed in 1 187 patients in 17 french centers between 1979 and October 1983. There were 855 primary successes (68.9 p. 100). There were 41 cases of symptomatic dissection (3.3 p. 100) of which 32 underwent aortocoronary bypass surgery with a residual myocardial infarction (MI) in 13 cases (40.6 p. 100). Medical treatment of symptomatic dissection gave very poor results (7 out of 9 MI) and is formally contra-indicated. 67 per- or postoperative occlusions were observed (5.3 p. 100). This is the most serious complication which necessitates an emergency revascularisation procedure (TCA or coronary bypass surgery--CBS--) because MI rapidly follows in patients without a well-developed collateral circulation. In this series MI occurred in 28 out of 45 patients--62 p. 100--despite CBS. This underlines the value of an immediate repeat TCA which, when successful, results in a much faster revascularisation. Seventy-three MI (5.8 p. 100) were observed in the first 24 hours: 50 p. 100 were secondary to an angiographically documented coronary occlusion. The other two causes were coronary dissection and spasm. Emergency CBS was carried out in 107 cases (8.9 p. 100) mainly for coronary occlusion or symptomatic dissection. The mortality was 11 out of 1 187 patients (0.93 p. 100). Death occurred in the catheter laboratory in 3 cases, during the first 24 hours in the operating theatre in 1 case, and after the first 24 hours but before hospital discharge in 7 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. The First Language in Science Class: A Quasi-Experimental Study in Late French Immersion

    ERIC Educational Resources Information Center

    Turnbull, Miles; Cormier, Marianne; Bourque, Jimmy

    2011-01-01

    This article reports analysis of data collected from a quasi-experimental study in 2 Canadian late French immersion science classes. We examine if, how, and when the first language (L1) is used when students in the first years of their second language learning talk about complex science concepts. We compare differences in groups following a…

  20. Perception by French Students of the Gendered Nature of Material Artifacts Studied in Technology Education

    ERIC Educational Resources Information Center

    Colette, Andreucci; Marjolaine, Chatoney

    2017-01-01

    Many studies have shown the importance of the socio-cultural factors that lead girls to desert scientific and technological courses. Over a long period, the contents of the French technology education (TE) college curricula may well have contributed to strengthening the feeling among girls that this discipline was better suited to boys. The choice…

  1. Chinese-French Case Study of English Language Learning via Wikispaces, Animoto and Skype

    ERIC Educational Resources Information Center

    Hartwell, Laura M.; Zou, Bin

    2013-01-01

    This paper reports on the learning experience of Chinese and French students participating in a computer mediated communication (CMC) collaboration conducted in English and supported by Wikispaces, Animoto, and Skype. Several studies have investigated CMC contexts in which at least some participants were native speakers. Here, we address the…

  2. The Acquisition of Pronouns by French Children: A Parallel Study of Production and Comprehension

    ERIC Educational Resources Information Center

    Zesiger, Pascal; Zesiger, Laurence Chillier; Arabatzi, Marina; Baranzini, Lara; Cronel-Ohayon, Stephany; Franck, Julie; Frauenfelder, Ulrich Hans; Hamann, Cornelia; Rizzi, Luigi

    2010-01-01

    This study examines syntactic and morphological aspects of the production and comprehension of pronouns by 99 typically developing French-speaking children aged 3 years, 5 months to 6 years, 5 months. A fine structural analysis of subject, object, and reflexive clitics suggests that whereas the object clitic chain crosses the subject chain, the…

  3. Blended Learning and Disciplinarity: Negotiating Connections in French Studies in Regional Universities

    ERIC Educational Resources Information Center

    Hughes, Neil; Rolls, Alistair

    2012-01-01

    In this article, we outline the challenges facing French Studies in regional Australian universities resulting from an increasingly vocational curriculum and doubts about the cost-effectiveness of language learning in higher education. These pressures have resulted in a process of discipline restructuring and significant cuts in the numbers of…

  4. The Rise and Fall of Mathematical Enrolments in the French Educational System: A Case Study

    ERIC Educational Resources Information Center

    Arnoux, Pierre; Duverney, Daniel; Holton, Derek

    2009-01-01

    In this article, we start by considering the relevant parts of the French educational system and the data relating to science at the end of secondary school and the early years of university. We show an increase, till 1995, and then a decline in the study of mathematics at baccalaureate and university level. However, our main conclusions relate to…

  5. French as a Second Language: Nine-Year Program of Studies (Grade 4 to Grade 12)

    ERIC Educational Resources Information Center

    Online Submission, 2004

    2004-01-01

    The nine-year program of studies for French as a Second Language (FSL) is a legal document that specifies from Grade 4 to 12 what Alberta students are expected to acquire as attitudes and linguistic, cultural, and strategic knowledge as they develop and demonstrate their communicative skills. This document contains an introduction, a rationale,…

  6. How Specific Is the Connection between Morphological Awareness and Spelling? A Study of French Children

    ERIC Educational Resources Information Center

    Casalis, S.; Deacon, S. H.; Pacton, S.

    2011-01-01

    This study examined the relationship between morphological awareness and spelling. We show that French children in Grades 3 and 4 appear to use morphological information in spelling; spelling of sounds for which there are several alternatives was more accurate in derived than in nonderived words. The link between morphological awareness and…

  7. Graphophonological Processes in Dyslexic Readers of French: A Longitudinal Study of the Explicitness Effect of Tasks

    ERIC Educational Resources Information Center

    Daigle, Daniel; Berthiaume, Rachel; Plisson, Anne; Demont, Elisabeth

    2012-01-01

    Given the well-acknowledged phonological deficit found in dyslexic children, this study was aimed at investigating graphophonological processes in dyslexic readers of French over a 1-year period. Among the different types of phonological processing can be distinguished those related to phonological awareness based on knowledge of the oral language…

  8. Upper Secondary French Students, Chemical Transformations and the "Register of Models": A Cross-Sectional Study

    ERIC Educational Resources Information Center

    Cokelez, Aytekin; Dumon, Alain; Taber, Keith S.

    2008-01-01

    The purpose of this study is to identify how upper secondary school French students (Grade 10-12) interpret chemical transformation with regards to the changes within molecules and atoms, and in terms of intramolecular and/or intermolecular bond breaking. In order to identify and describe the students' assimilated knowledge, four questions were…

  9. A Comparative Study of French and Turkish Students' Ideas on Acid-Base Reactions

    ERIC Educational Resources Information Center

    Cokelez, Aytekin

    2010-01-01

    The goal of this comparative study was to determine the knowledge that French and Turkish upper secondary-school students (grades 11 and 12) acquire on the concept of acid-base reactions. Following an examination of the relevant curricula and textbooks in the two countries, 528 students answered six written questions about the acid-base concept.…

  10. The French Version of the Modified-Checklist for Autism in Toddlers (M-CHAT): A Validation Study on a French Sample of 24 Month-Old Children.

    PubMed

    Baduel, Sophie; Guillon, Quentin; Afzali, Mohammad H; Foudon, Nadège; Kruck, Jeanne; Rogé, Bernadette

    2017-02-01

    Early ASD screening has the potential to reduce delays between initial parental concerns and diagnosis, and promote early intervention. The aim of this study was to validate the M-CHAT on a French population sample of 24 month-old children. This study included a low-risk sample of 1227 children. A total of 20 children screened positive on the M-CHAT. Twelve out of 20 of these children received a diagnosis of ASD at 36 months, yielding a PPV of 0.60. These results add to the evidence that the M-CHAT is a useful screening instrument and further demonstrates the importance of the follow-up interview in primary care settings. This study provides French practitioners with guidelines regarding the use of the M-CHAT at 24 months.

  11. [Trends and evolutions of French breast cancer research: a bibliometric study].

    PubMed

    Thonon, Frédérique; Saghatchian, Mahasti; Nerfie, Alexia; Delaloge, Suzette

    2015-05-01

    This article presents a bibliometric study carried out in order to describe the trends and evolutions of French breast cancer research from 2003 to 2013. The results show an increase in the number of publications, especially international publications coordinated by non-French institutions. The most visible topics, in terms of number of publications by keywords, are related to biology, clinical trials and genetics. Most publications are written by authors affiliated to comprehensive cancer centres, followed by universities, research centres, university hospitals and governmental agencies. The importance of publications by topic varies throughout the years: there has been an increase of the number of publications related to targeted therapies or genomics. The importance of institutions or country affiliation of authors varies with the topics. This study, especially the analysis by keywords, enables the coordinators of research programs to identify the predominant actors and themes.

  12. Wild gudgeons (Gobio gobio) from French rivers are contaminated by microplastics: preliminary study and first evidence.

    PubMed

    Sanchez, Wilfried; Bender, Coline; Porcher, Jean-Marc

    2014-01-01

    Marine ecosystem contamination by microplastics is extensively documented. However few data is available on the contamination of continental water bodies and associated fauna. The aim of this study was to address the occurrence of microplastics in digestive tract of gudgeons (Gobio gobio) from French rivers. These investigations confirm that continental fish ingested microplastics while 12% of collected fish are contaminated by these small particles. Further works are needed to evaluate the occurence of this contamination.

  13. Confirmed Beliefs or False Assumptions? A Study of Home Stay Experiences in the French Study Abroad Context

    ERIC Educational Resources Information Center

    Diao, Wenhao; Freed, Barbara; Smith, Leigh

    2011-01-01

    The past 20 years have witnessed enormous growth in a diverse array of studies which explore the linguistic impact of study abroad (SA) experiences. During this period a multitude of research projects have investigated SLA/L2 learning in SA, in a number of different languages (Russian, Japanese, French, Spanish, English), utilizing diverse…

  14. Grammatical and Situational Aspect in French: A Developmental Study

    ERIC Educational Resources Information Center

    Labelle, Marie; Godard, Lucie; Longtin, Catherine-Marie

    2002-01-01

    We study the ability of children to provide an appropriate continuation for a stimulus sentence, taking into account the joint demands of situational aspect and grammatical aspect. We hypothesize that the aspectual transitions required by some aspectual combinations play a role in the difficulty of providing an appropriate continuation for them.…

  15. Dietary patterns, goitrogenic food, and thyroid cancer: a case-control study in French Polynesia.

    PubMed

    Cléro, Énora; Doyon, Françoise; Chungue, Vaïana; Rachédi, Frédérique; Boissin, Jean-Louis; Sebbag, Joseph; Shan, Larrys; Rubino, Carole; de Vathaire, Florent

    2012-01-01

    French Polynesia has one of the world's highest thyroid cancer incidence rates. A case-control study among native residents of French Polynesia included 229 cases of differentiated thyroid cancer diagnosed between 1979 and 2004, and 371 population controls. Dietary patterns and goitrogenic food consumption (cabbage, cassava) were analyzed. We used a factor analysis to identify dietary patterns and a conditional logistic regression analysis to investigate the association between dietary patterns or food items and thyroid cancer risk. Two distinct dietary patterns were identified: traditional Polynesian and Western. A nonsignificant inverse association was observed between the traditional Polynesian dietary pattern and thyroid cancer risk. The Western pattern was not associated with thyroid cancer risk. Cassava consumption was significantly associated with a decreased risk of thyroid cancer. In conclusion, a traditional Polynesian dietary pattern led to a weak reduced risk of thyroid cancer in French Polynesia. The protective effect of cassava on this cancer does not seem to be substantially different from that of cabbage, which was the main goitrogenic food studied to date.

  16. Predictive factors of unprotected sex for female sex workers: first study in French Guiana, the French territory with the highest HIV prevalence

    PubMed Central

    Parriault, Marie-Claire; Basurko, Célia; Van Melle, Astrid; Gaubert-Maréchal, Emilie; Rogier, Stéphanie; Couppié, Pierre; Nacher, Mathieu

    2015-01-01

    French Guiana is the French territory that is most affected by HIV. AIDS incidence is much higher than in mainland France and sex work seems to be an important driver of the epidemic. The objective of this study was to describe consistent condom use among female sex workers (FSW) with their clients and their intimate partners and to identify determinants of non-use of condoms. An HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey was conducted in 2009–2010 among sex workers in French Guiana. A total of 477 sex workers were interviewed. FSW were more likely to use condoms with their clients (97%) than with their intimate partners (45%). The factors associated with non consistent condom use with the intimate partner were having had an abortion, feeling at risk for HIV, not evaluating one’s own risk for HIV, living as a couple, being Dominican, not feeling comfortable asking intimate partners to use condoms. Although, a high proportion of FSW declared using condoms with commercial partners, there is still room for improvement in the prevention of transmission with both commercial and intimate partners. PMID:25080287

  17. Predictive factors of unprotected sex for female sex workers: first study in French Guiana, the French territory with the highest HIV prevalence.

    PubMed

    Parriault, Marie-Claire; Basurko, Célia; Melle, Astrid Van; Gaubert-Maréchal, Emilie; Rogier, Stéphanie; Couppié, Pierre; Nacher, Mathieu

    2015-07-01

    French Guiana is the French territory that is most affected by HIV. AIDS incidence is much higher than in mainland France and sex work seems to be an important driver of the epidemic. The objective of this study was to describe consistent condom use among female sex workers with their clients and their intimate partners and to identify determinants of non-use of condoms. An HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey was conducted in 2009-2010 among sex workers in French Guiana. A total of 477 sex workers were interviewed. Female sex workers were more likely to use condoms with their clients (97%) than with their intimate partners (45%). The factors associated with non-consistent condom use with the intimate partner were having had an abortion, feeling at risk for HIV, not evaluating one's own risk for HIV, living as a couple, being Dominican, and not feeling comfortable asking intimate partners to use condoms. Although a high proportion of female sex workers declared using condoms with commercial partners, there is still room for improvement in the prevention of transmission with both commercial and intimate partners.

  18. Adherence to Hypothermia Guidelines: A French Multicenter Study of Fullterm Neonates

    PubMed Central

    Chevallier, Marie; Ego, Anne; Cans, Christine; Debillon, Thierry

    2013-01-01

    Aim The objective of this study was to describe the French practice of hypothermia treatment (HT) in full-term newborns with hypoxic-ischemic encephalopathy (HIE) and to analyze the deviations from the guidelines of the French Society of Neonatology. Materials and Methods From May 2010 to March 2012 we recorded all cases of HIE treated by HT in a French national database. The population was divided into three groups, "optimal HT" (OHT), “late HT” (LHT) and “non-indicated” HT (NIHT), according to the guidelines. Results Of the 311 newborns registered in the database and having HT, 65% were classified in the OHT group, 22% and 13% in the LHT and NIHT groups respectively. The severity of asphyxia and HIE were comparable between newborns with OHT and LHT, apart from EEG. HT was initiated at a mean time of 12 hours of life in the LHT group. An acute obstetrical event was more likely to be identified among newborns with LHT (46%), compared to OHT (34%) and NIHT (22%). There was a gradation in the rate of complications from the NIHT group (29%) to the LHT (38%) group and the OHT group (52%). Despite an insignificant difference in the rates of death or abnormal neurological examination at discharge, nearly 60% of newborns in the OHT group had an MRI showing abnormalities, compared to 44% and 49% in the LHT and NIHT groups respectively. Conclusion The conduct of the HT for HIE newborns is not consistent with French guidelines for 35% of newborns, 22% being explained by an excessive delay in the start of HT, 13% by the lack of adherence to the clinical indications. This first report illustrates the difficulties in implementing guidelines for HT and should argue for an optimization of perinatal care for HIE. PMID:24391817

  19. [Magnet ingestions in children: a French multicenter study].

    PubMed

    Talvard, M; Mouttalib, S; Flaum, V; Viala, J; Galinier, P; Olives, J-P; Mas, E

    2015-01-01

    Digestive complications related to the ingestion of magnetic foreign bodies in children are increasing, especially in Asia and North America. In France, several case reports have been reported since 2008. We conducted a retrospective multicentric study to evaluate the frequency of ingestion of magnet foreign bodies and to describe the complicated cases that have occurred in France over the last 5 years. We report 40 cases of which 60% were multiple magnet ingestions. Eighty-eight percent of the children of the group who had swallowed multiple magnets needed interventional management by endoscopy (33%) or surgery (58%). Only two children (12.5%) of the group who swallowed one magnet required removal. This problem is not uncommon in France (2% of the 1132 foreign bodies investigated in the Toulouse center over 5 years), which justifies clear information for healthcare professionals and caregivers in order to avoid potential intestinal complications. We suggest interventional management or very close monitoring in the cases of multiple magnet ingestion. Meanwhile, in the majority of confirmed cases of simple magnet ingestions, we propose home monitoring.

  20. Morphostructural study of the Belledonne faults system (French Alps).

    NASA Astrophysics Data System (ADS)

    Billant, Jérémy; Bellier, Olivier; Hippolyte, Jean-Claude; Godard, Vincent; Manchuel, Kevin

    2016-04-01

    The NE trending Belledonne faults system, located in the Alps, is a potentially active faults system that extends from the Aiguilles Rouges and Mont Blanc massifs in the NE to the Vercors massif in the SW (subalpine massifs). It includes the Belledonne border fault (BBF), defined by an alignment of micro earthquakes (ML≤3.5) along the eastern part of the Grésivaudan valley (Thouvenot et al., 2003). Focal mechanisms and their respective depths tend to confirm a dextral strike-slip faulting at crustal scale. In the scope of the Sigma project (http://projet-sigma.com/index.html, EDF), this study aims at better constraining the geometry, kinematic and seismogenic potential of the constitutive faults of the Belledonne fault system, by using a multidisciplinary approach that includes tectonics, geomorphology and geophysics. Fault kinematic analysis along the BBF (Billant et al., 2015) and the Jasneuf fault allows the determination of a strike-slip tectonic regime characterised by an ENE trending σ1 stress axes, which is consistent with stress state deduced from the focal mechanisms. Although no morphological anomalies could be related to recent faulting along the BBF, new clues of potential Quaternary deformations were observed along the other faults of the system: -right lateral offset of morphologic markers (talwegs...) along the NE trending Arcalod fault located at the north-eastern terminations of the BBF; -left lateral offset of the valley formed by the Isère glacier along the NW trending Brion fault which is consistent with its left-lateral slip inferred from the focal mechanisms; -fault scarps and right lateral offsets of cliffs bordering a calcareous plateau and talwegs along the four fault segments of the NE trending Jasneuf fault located at the south-western termination of the BBF in the Vercors massif. Some offsets were measured using a new method that does not require the identification of piercing points and take advantage of the high resolution

  1. Teaching French.

    ERIC Educational Resources Information Center

    Marty, Fernand

    This comprehensive analysis of French teaching methodology reveals basic problems underlying the current philosophy of language learning, while presenting new ideas based on extensive research. Two books, "Active French; Dialogues" and "Active French: Foundations Course" (Books 1 and 2), which stress well specified learning objectives, were…

  2. Le "Francais Populaire" and French as a Second Language: A Comparative Study of Language Simplification.

    ERIC Educational Resources Information Center

    Kenemer, Virginia Lynn

    The French of English speaking students of French as a second language is compared with "francais populaire" (FP) in order to determine similarities in their tendency toward simplified grammar and morphology. Simplifying characteristics that are typical of FP were obtained from French working class sources, while simplification patterns…

  3. Factor Structure of the French Version of the Wechsler Adult Intelligence Scale-III. Validity Studies

    ERIC Educational Resources Information Center

    Gregoire, Jacques

    2004-01-01

    The standardization of the French version of the Wechsler Adult Intelligence Scale (WAIS-III) was conducted after carefully adapting the French version from the U.S. version and extensive field testing. The standardization sample was composed of 1,104 participants from 16 to 89 years. To assess the construct validity of the French version,…

  4. Producing Multimodal Picture Books and Dramatic Performances in a Core French Classroom: An Exploratory Case Study

    ERIC Educational Resources Information Center

    Early, Margaret; Yeung, Cindy

    2009-01-01

    In a Grade 9 core French class, the teacher designed a multi-stage project in which students composed original children's stories in French; illustrated their stories to produce picture books; then, in groups, adapted one group member's story into a play script; and, finally, dramatized the scripts for children from the local French immersion…

  5. English-French Bilingual Education in the Early Grades: The Elgin Study through Grade Four

    ERIC Educational Resources Information Center

    Barik, Henri C.; Swain, Merrill

    1976-01-01

    This paper presents the results of an evaluation of a bilingual education program for English-speaking pupils, grades 1-4, in Ontario. It is a partial French immersion program, with instruction in French or English half of each day. Evaluative tests are described, and English and French language skills examined. (CHK)

  6. Early Predictors of Biliteracy Development in Children in French Immersion: A 4-Year Longitudinal Study

    ERIC Educational Resources Information Center

    Jared, Debra; Cormier, Pierre; Levy, Betty Ann; Wade-Woolley, Lesly

    2011-01-01

    English language predictors of English and French reading development were investigated in a group of 140 children who were enrolled in French immersion programs. Children were first tested in kindergarten, and their reading achievement was tested yearly in both English and French from Grades 1 to 3, with word-level and passage-level measures that…

  7. Dietary patterns in the French adult population: a study from the second French national cross-sectional dietary survey (INCA2) (2006-2007).

    PubMed

    Gazan, R; Béchaux, C; Crépet, A; Sirot, V; Drouillet-Pinard, P; Dubuisson, C; Havard, S

    2016-07-01

    Identification and characterisation of dietary patterns are needed to define public health policies to promote better food behaviours. The aim of this study was to identify the major dietary patterns in the French adult population and to determine their main demographic, socio-economic, nutritional and environmental characteristics. Dietary patterns were defined from food consumption data collected in the second French national cross-sectional dietary survey (2006-2007). Non-negative-matrix factorisation method, followed by a cluster analysis, was implemented to derive the dietary patterns. Logistic regressions were then used to determine their main demographic and socio-economic characteristics. Finally, nutritional profiles and contaminant exposure levels of dietary patterns were compared using ANOVA. Seven dietary patterns, with specific food consumption behaviours, were identified: 'Small eater', 'Health conscious', 'Mediterranean', 'Sweet and processed', 'Traditional', 'Snacker' and 'Basic consumer'. For instance, the Health-conscious pattern was characterised by a high consumption of low-fat and light products. Individuals belonging to this pattern were likely to be older and to have a better nutritional profile than the overall population, but were more exposed to many contaminants. Conversely, individuals of Snacker pattern were likely to be younger, consumed more highly processed foods, had a nutrient-poor profile but were exposed to a limited number of food contaminants. The study identified main dietary patterns in the French adult population with distinct food behaviours and specific demographic, socio-economic, nutritional and environmental features. Paradoxically, for better dietary patterns, potential health risks cannot be ruled out. Therefore, this study demonstrated the need to conduct a risk-benefit analysis to define efficient public health policies regarding diet.

  8. First epidemiological study on occupational radar exposure in the French Navy: a 26-year cohort study.

    PubMed

    Dabouis, Vincent; Arvers, Philippe; Debouzy, Jean-Claude; Sebbah, Charles; Crouzier, David; Perrin, Anne

    2016-01-01

    This retrospective cohort study deals with the causes of death among 57,000 military personnel who served in the French Navy surface vessels and were observed over the period 1975-2000. We successively compared the mortality rate and the specific causes of death between two groups differing in their potential exposure levels to radar. Occupational exposure was defined according to the on-board workplace (radar and control groups). The age-adjusted death ratios of the navy personnel were compared. For all causes of death, the results showed that 885 deaths in the radar group and 299 in the control group occurred (RR = 1.00 (95% CI: 0.88-1.14)). RRs were 0.92 (95% CI: 0.69-1.24) for neoplasms. For the duration of follow-up, the results did not show an increased health risk for military personnel exposed to higher levels of radio frequencies in the radar group, but the number of deaths was very small for some cancer sites.

  9. Impact of Resident Rotations on Critically Ill Patient Outcomes: Results of a French Multicenter Observational Study

    PubMed Central

    Guidet, Bertrand; Aegerter, Philippe; Mentec, Hervé

    2016-01-01

    Purpose The impact of resident rotation on patient outcomes in the intensive care unit (ICU) has been poorly studied. The aim of this study was to address this question using a large ICU database. Methods We retrospectively analyzed the French CUB-REA database. French residents rotate every six months. Two periods were compared: the first (POST) and fifth (PRE) months of the rotation. The primary endpoint was ICU mortality. The secondary endpoints were the length of ICU stay (LOS), the number of organ supports, and the duration of mechanical ventilation (DMV). The impact of resident rotation was explored using multivariate regression, classification tree and random forest models. Results 262,772 patients were included between 1996 and 2010 in the database. The patient characteristics were similar between the PRE (n = 44,431) and POST (n = 49,979) periods. Multivariate analysis did not reveal any impact of resident rotation on ICU mortality (OR = 1.01, 95% CI = 0.94; 1.07, p = 0.91). Based on the classification trees, the SAPS II and the number of organ failures were the strongest predictors of ICU mortality. In the less severe patients (SAPS II<24), the POST period was associated with increased mortality (OR = 1.65, 95%CI = 1.17–2.33, p = 0.004). After adjustment, no significant association was observed between the rotation period and the LOS, the number of organ supports, or the DMV. Conclusion Resident rotation exerts no impact on overall ICU mortality at French teaching hospitals but might affect the prognosis of less severe ICU patients. Surveillance should be reinforced when treating those patients. PMID:27627449

  10. Comparing Written Competency in Core French and French Immersion Graduates

    ERIC Educational Resources Information Center

    Lappin-Fortin, Kerry

    2014-01-01

    Few studies have compared the written competency of French immersion students and their core French peers, and research on these learners at a postsecondary level is even scarcer. My corpus consists of writing samples from 255 students from both backgrounds beginning a university course in French language. The writing proficiency of core French…

  11. Effect of frying instructions for food handlers on acrylamide concentration in French fries: an explorative study.

    PubMed

    Sanny, M; Luning, P A; Jinap, S; Bakker, E J; van Boekel, M A J S

    2013-03-01

    The objective of this study was to obtain insight into the effect of frying instructions on food handlers' control decisions in restaurants and to investigate the impact of control decisions on the variation and concentration of acrylamide in French fries. The concentrations of acrylamide and reducing sugars were analyzed, the frying temperature and time were measured, and thawing practices were observed. The results obtained before and after instructions were provided to the food handlers were compared for restaurants as a group and for each restaurant. Frying instructions supported food handlers' decisions to start frying when the oil temperature reached 175°C; all handlers started frying at the correct temperature. However, the effect of the instructions on the food handlers' decisions for frying time differed; most handlers increased the frying time beyond 240 s to achieve crispier French fries with a final color dictated by their preference. Providing instructions did not result in a significant difference in the mean concentration of acrylamide in French fries for the restaurants as a group. However, data analyzed for each restaurant revealed that when food handlers properly followed the instructions, the mean concentration of acrylamide was significantly lower (169 μg/kg) than that before instructions were provided (1,517 μg/kg). When food handlers did not complying with the frying instructions, mean acrylamide concentrations were even higher than those before instructions were provided. Two different strategies were developed to overcome the noncompliant behavior of food handlers: establishing requirements for the features of commercial fryers and strict monitoring of compliance with instructions.

  12. High prevalence of HPV infection in the remote villages of French Guiana: an epidemiological study.

    PubMed

    Adenis, A; Dufit, V; Douine, M; Corlin, F; Ayhan, G; Najioullah, F; Molinie, V; Brousse, P; Carles, G; Lacoste, V; Cesaire, R; Nacher, M

    2017-04-01

    Cervical cancer is the second most frequent cancer in women in French Guiana. Studies have shown that populations living in the remote areas of the interior have early sexual debut and that multiple sexual partnerships are common. The objective of the present study was thus to determine the prevalence of human papillomavirus (HPV) infection in these areas. A study was conducted in women aged 20-65 years with previous sexual activity. Women were included on a voluntary basis after using local media and leaders to inform them of the visit of the team. HPV infection was defined by the detection of HPV DNA using the Greiner Bio-One kit. In addition to HPV testing cytology was performed. The overall age-standardized prevalence rate was 35%. There was a U-shaped evolution of HPV prevalence by age with women aged >50 years at highest risk for HPV, followed by the 20-29 years group. Twenty-seven percent of women with a positive HPV test had normal cytology. Given the high incidence of cervical cancer in French Guiana and the high prevalence of HPV infections the present results re-emphasize the need for screening for cervical cancer in these remote areas. Vaccination against HPV, preferably with a nonavalent vaccine, also seems an important prevention measure. However, in this region where a large portion of the population has no health insurance, this still represents a challenge.

  13. Manual wheelchair satisfaction among long-term users and caregivers: a French study.

    PubMed

    Marchiori, Claire; Bensmail, Djamel; Gagnon, Dany; Pradon, Didier

    2015-01-01

    Wheelchair mobility is a prerequisite to being able to carry out important activities and to participate in social life. Level of satisfaction with the wheelchair and overall quality of life were found to be positively associated. The aim of this study was to determine the level of satisfaction of French manual wheelchair (MW) users and caregivers with MW characteristics. A total of 132 users and 76 caregivers completed a questionnaire about their level of satisfaction with their MW characteristics. Satisfaction scores were independent of age, sex, reason for MW use, and time of use. As a whole, MW users are satisfied. However, a few parameters such as MW weight and difficulties propelling outdoors demonstrate a low level of satisfaction among users. MW weight, brakes, and height of pushing handles are the less satisfying elements among caregivers. In conclusion, the majority of French MW users are satisfied, but some characteristics, such as weight, must be optimized. Considering caregiver needs is paramount when aiming to improve MW parameters such as brakes or pushing handles. Improvement in some wheelchair parameters seems to be important in achieving improved level of satisfaction and increased participation and active lifestyle among MW users and caregivers.

  14. The Study of the Phenomenon of Hesitation as a Cognitive Process in Iranian French Learners' Oral Production

    ERIC Educational Resources Information Center

    Rahmatian, Rouhollah; Mehrabi, Marzieh; Safa, Parivash; Golfam, Arsalan

    2014-01-01

    Hesitation, when speaking a foreign language, is studied through its components: beginnings, pauses, and repetitions. This paper aims to identify, through the study of this phenomenon, vulnerable zones among Iranian learners when they speak French. A case study of 30 adult learners shows that hesitation is not random and at different levels (A1 to…

  15. [The influence of culture in the oral expression of pain: comparative study between French and Syrian cancer patients].

    PubMed

    Lebreuilly, Romain; Sakkour, Sam; Lebreuilly, Joëlle

    2013-03-01

    This study examines the role of culture in the perception and the verbal expression of pain among syrian and french blood-related cancer patients. The level of intensity (AVS scale) and the different aspects (Saint-Antoine Pain Questionnaire [SAPQ]) of their pain were studied. The sensory and emotional descriptors chosen by the Syrian possessed a stronger semantic content in comparison to those used by the French. The patient's cultural background, which affect the perception and verbal expression of pain should be a new indicator in the optimization of global medical management.

  16. Childhood leukemia around French nuclear power plants--the Geocap study, 2002-2007.

    PubMed

    Sermage-Faure, Claire; Laurier, Dominique; Goujon-Bellec, Stéphanie; Chartier, Michel; Guyot-Goubin, Aurélie; Rudant, Jérémie; Hémon, Denis; Clavel, Jacqueline

    2012-09-01

    The aim of this work is to study the risk of childhood acute leukemia (AL) around French nuclear power plants (NPPs). The nationwide Geocap case-control study included the 2,753 cases diagnosed in mainland France over 2002-2007 and 30,000 contemporaneous population controls. The last addresses were geocoded and located around the 19 NPPs. The study used distance to NPPs and a dose-based geographic zoning (DBGZ), based on the estimated dose to bone marrow related to NPP gaseous discharges. An odds ratio (OR) of 1.9 [1.0-3.3], based on 14 cases, was evidenced for children living within 5 km of NPPs compared to those living 20 km or further away, and a very similar association was observed in the concomitant incidence study (standardized incidence ratio (SIR)=1.9 [1.0-3.2]). These results were similar for all the 5-year-age groups. They persisted after stratification for several contextual characteristics of the municipalities of residence. Conversely, using the DBGZ resulted in OR and SIR close to one in all of the dose categories. There was no increase in AL incidence over 1990-2001 and over the entire 1990-2007 period. The results suggest a possible excess risk of AL in the close vicinity of French NPPs in 2002-2007. The absence of any association with the DBGZ may indicate that the association is not explained by NPP gaseous discharges. Overall, the findings call for investigation for potential risk factors related to the vicinity of NPP and collaborative analysis of multisite studies conducted in various countries.

  17. Continuing French in Grade Four: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching French to Fourth-Grade Children.

    ERIC Educational Resources Information Center

    Thompson, Mary P.; And Others

    This teacher's guide for use in a fourth-grade French course concentrates on the development of basic audiolingual skills. Twelve lessons, each containing an exposition, dialogue, teaching procedures, and dialogue adaptation, emphasize the use of French during classroom instruction. Lessons include: (1) a review unit, (2) "La chemise neuve," (3)…

  18. From Crisis to Opportunity: French and Foreign Language Studies in the Twenty-First Century.

    ERIC Educational Resources Information Center

    Spencer, Samia I.

    2003-01-01

    In response to falling enrollments in French and a diminishing pool of high school teachers, faculty at Auburn University tried to turn the tide through a series of curricular and advocacy initiatives. They introduced new French majors in education and in international trade and a collaborative major with the Consumer Affairs Department in French…

  19. EMPIRICAL STUDIES RELATED TO THE TEACHING OF FRENCH PRONUNCIATION TO AMERICAN STUDENTS.

    ERIC Educational Resources Information Center

    CLARK, JOHN L.D.

    THIS REPORT DESCRIBES IN DETAIL FIVE RELATED EXPERIMENTS THAT WERE CONDUCTED IN AREAS PERTAINING TO THE TEACHING OF FRENCH PRONUNCIATION TO NATIVE SPEAKERS OF AMERICAN ENGLISH. THE FIRST TWO EXPERIMENTS SOUGHT TO DETERMINE THE RELATIVE ACCEPTABILITY OF 38 ENGLISH PHONEMES TO NATIVE FRENCH LISTENERS AT EACH OF TWO ACCEPTABILITY LEVELS--PHONEMIC AND…

  20. Le Francais parle. Etudes sociolinguistiques (Spoken French. Sociolinguistic Studies). Current Inquiry into Languages and Linguistics 30.

    ERIC Educational Resources Information Center

    Thibault, Pierrette

    This volume contains twelve articles dealing with the French language as spoken in Quebec. The following topics are addressed: (1) language change and variation; (2) coordinating expressions in the French spoken in Montreal; (3) expressive language as source of language change; (4) the role of correction in conversation; (5) social change and…

  1. English and French Journal Abstracts in the Language Sciences: Three Exploratory Studies

    ERIC Educational Resources Information Center

    Van Bonn, Sarah; Swales, John M.

    2007-01-01

    This article compares French and English academic article abstracts from the language sciences in an attempt to understand how and why language choice might affect this part-genre--both in actual use and according to authors' linguistic and rhetorical perceptions. Two corpora are used: Corpus A consists of abstracts from a French linguistics…

  2. [Drugs and retinal disorders: A case/non-case study in the French pharmacovigilance database].

    PubMed

    Bourgeois, Nicolas; Chavant, François; Lafay-Chebassier, Claire; Leveziel, Nicolas; Pérault-Pochat, Marie-Christine

    2016-09-01

    Retina is the part of the eye suffering most damage from pharmaceutical molecules. Drug-induced retinopathies have been described but data are scarce and sometimes conflicting especially concerning its potential seriousness. The aim of this study was to investigate potential associations between drugs and retinal disorders using the French Pharmacovigilance data. We used the case/non-case method in the French PharmacoVigilance Database (FPVD) to identify drugs able to induce retinopathies. Cases were reports of retinal disorders in the FPVD between January 2008 and December 2012. Non-cases were all other reports during the same period. To assess the association between retinopathy and drug intake, we calculated the odds-ratio (OR) [with their 95% confidence intervals] for all drugs associated with at least 3 cases of retinopathy. Among the 123 687 adverse drug reactions recorded during the studied period, we identified 164 cases of retinal disorders. Significant associations were found for 11 drugs. The main therapeutic classes were antirhumatismals (hydroxychloroquine, chloroquine and etanercept: 18 cases), anti-infective (ribavirine, PEG-interferon-alfa-2a and cefuroxime: 16 cases) and antineoplastic drugs (imatinib and letrozole: 8 cases. Three other drugs were also found: raloxifene (5 cases), erythropoietin beta (4 cases) and ranibizumab (3 cases). Taking into account the limits of the methodology, our study confirmed the association between retinopathy and some expected drugs such as aminoquinolines, interferons, imatinib or ranibizumab. Other drugs like erythropoietin beta, cefuroxime, letrozole and etanercept were significantly associated with retinal disorders although this was not or poorly described in the literature. Thus, further prospective studies are necessary to confirm such associations.

  3. A Cross-Linguistic Study of the Development of Gesture and Speech in Zulu and French Oral Narratives

    ERIC Educational Resources Information Center

    Nicolas, Ramona Kunene; Guidetti, Michele; Colletta, Jean-Marc

    2017-01-01

    The present study reports on a developmental and cross-linguistic study of oral narratives produced by speakers of Zulu (a Bantu language) and French (a Romance language). Specifically, we focus on oral narrative performance as a bimodal (i.e., linguistic and gestural) behaviour during the late language acquisition phase. We analyzed seventy-two…

  4. [Historical and biological approaches to the study of Modern Age French plague mass burials].

    PubMed

    Bianuccii, Raffaella; Tzortzis, Stéfan; Fornaciari, Gino; Signoli, Michel

    2010-01-01

    The "Black Death" and subsequent epidemics from 1346 to the early 18th century spread from the Caspian Sea all over Europe six hundred years after the outbreak of the Justinian plague (541-767 AD). Plague has been one of the most devastating infectious diseases that affected the humankind and has caused approximately 200 million human deaths historically. Here we describe the different approaches adopted in the study of several French putative plague mass burials dating to the Modern Age (16th-18th centuries). Through complementation of historical, archaeological and paleobiological data, ample knowledge of both the causes that favoured the spread of the Medieval plague in cities, towns and small villages and of the modification of the customary funerary practices in urban and rural areas due to plague are gained.

  5. The expression of cognitive vulnerabilities for depression in daily life: a French-American study.

    PubMed

    Swendsen, J D; Compagnone, P

    2000-06-01

    This prospective study provided a direct comparison of French and American samples concerning a cognitive diathesis for depression. Using the Experience Sampling Method and identical measures across sites, subjects were signaled five times daily by electronic devices to provide in vivo reports of negative events, attributions, and depressed moods. After controlling for effects associating clinical and demographic variables, and despite differences attributable to national origin, attributional style emerged as a highly significant predictor of the numerous specific attributions made to negative events within the course of daily life. However, consistent with the cognitive mediation hypothesis, attributional style did not directly explain depression levels. The results are discussed in terms of the predictive power of cognitive and personality assessments in understanding the day-to-day experience of depression.

  6. Acquisition of Derivational Lexical Rules: A Case Study of the Acquisition of French Agent Noun Forms by L2 Learners

    ERIC Educational Resources Information Center

    Redouane, Rabia

    2007-01-01

    This study investigates L2 learners' use of French derivational processes and their strategies as they form agent nouns. It also attempts to find out which of the acquisitional principles (conventionality, semantic transparency, formal simplicity, and productivity) advanced by Clark (1993, 2003) for various L1s acquisition of word formation…

  7. The Impact of New Work Technologies on Training. Five Case Studies in French Industry. Discussion Paper No. 81.

    ERIC Educational Resources Information Center

    Araujo e Oliveira, Joao Batista

    Case studies of five French firms illustrate the impact of new work technologies on training. Liquid Corporation has embarked on changes in production technology in response to market needs. Four aspects of the change process are as follows: creating the climate for change, selecting operators, defining new training requirements, and training for…

  8. Severe Traumatic Brain Injury, Frontal Lesions, and Social Aspects of Language Use: A Study of French-Speaking Adults

    ERIC Educational Resources Information Center

    Dardier, Virginie; Bernicot, Josie; Delanoe, Anaig; Vanberten, Melanie; Fayada, Catherine; Chevignard, Mathilde; Delaye, Corinne; Laurent-Vannier, Anne; Dubois, Bruno

    2011-01-01

    The purpose of this study was to gain insight into the social (pragmatic) aspects of language use by French-speaking individuals with frontal lesions following a severe traumatic brain injury. Eleven participants with traumatic brain injury performed tasks in three areas of communication: production (interview situation), comprehension (direct…

  9. Cross-Language Transfer of Orthographic Processing Skills: A Study of French Children Who Learn English at School

    ERIC Educational Resources Information Center

    Commissaire, Eva; Duncan, Lynne G.; Casalis, Severine

    2011-01-01

    This study explores the nature of orthographic processing skills among French-speaking children in Grades 6 and 8 who are learning English at school as a second language (L2). Two aspects of orthographic processing skills are thought to form a convergent construct in monolingual beginning readers: word-specific knowledge (e.g. "rain-rane") and…

  10. Intentional Control and Operational Constraints in Prosodic Phrasing: A Study of Picture-Elicited Narrations by French Children

    ERIC Educational Resources Information Center

    Vion, Monique; Colas, Annie

    2009-01-01

    This study deals with the determinants of prosodic phrasing in French schoolchildren's narratives. Children (aged 7 to 11) told picture stories to a silent same-age peer. The establishment of temporal and/or causal relations between the events was more or less guided by the drawings (ordered vs. arbitrary sequences). The comprehension of the…

  11. Evaluating the Risks of School Dropout amongst Children in the Care of the French Child Protection System: An Exploratory Study

    ERIC Educational Resources Information Center

    Derivois, Daniel; Guillier-Pasut, Nathalie; Karray, Amira; Cénat, Jude-Mary; Brolles, Lisbeth; Matsuhara, Hanae

    2015-01-01

    The aim of this pilot study is to identify the best way of preventing and assessing the livelihood and risk of school dropout amongst children entrusted to the care of the French child protection system in the Département of Rhone. The sample comprised 91 children and adolescents aged 4- to 17-years-old, of whom 45 were girls. The data were…

  12. Phrase-Final Prepositions in Quebec French: An Empirical Study of Contact, Code-Switching and Resistance to Convergence

    ERIC Educational Resources Information Center

    Ormel, Ellen; Hermans, Daan; Knoors, Harry; Verhoeven, Ludo

    2012-01-01

    In this study, we investigate whether preposition stranding, a stereotypical non-standard feature of North American French, results from convergence with English, and the role of bilingual code-switchers in its adoption and diffusion. Establishing strict criteria for the validation of contact-induced change, we make use of the comparative…

  13. English-French Bilingual Education in the Early Grades: The Elgin Study

    ERIC Educational Resources Information Center

    Barik, Henri C.; Swain, Merrill

    1974-01-01

    Presents findings of an evaluation of an English-French bilingual education program using partial instruction in the second language in St. Thomas, Ontario. The evaluation covers grades 1-3. The program operates in unilingual English environment. (RM)

  14. Three-Year Evaluation of a Large Scale Early Grade French Immersion Program: The Ottawa Study

    ERIC Educational Resources Information Center

    Barik, Henri; Swain, Marrill

    1975-01-01

    The school performance of pupils in grades K-2 of the French immersion program in operation in Ottawa public schools is evaluated in comparison with that of pupils in the regular English program. (Author/RM)

  15. A Diachronic Study of Initial Stress and Other Prosodic Features in the French News Announcer Style: Corpus-Based Measurements and Perceptual Experiments

    ERIC Educational Resources Information Center

    de Mareuil, Philippe Boula; Rilliard, Albert; Allauzen, Alexandre

    2012-01-01

    This study focuses on prosodic evolution in the French news announcer style, based on acoustic and perceptual analysis of French audiovisual archives. A 10-hour corpus covering six decades of broadcast news is investigated automatically. Two prosodic features, which may give an impression of emphatic style, are explored: word-initial stress and…

  16. Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study.

    PubMed

    Drubay, Damien; Caër-Lorho, Sylvaine; Laroche, Pierre; Laurier, Dominique; Rage, Estelle

    2015-05-01

    A significant association has been observed between radon exposure and cerebrovascular disease (CeVD) mortality among French uranium miners, but risk factors for circulatory system diseases (CSD) have not been previously considered. We conducted new analyses in the recently updated (through 2007) French cohort of uranium miners (n = 5,086), which included 442 deaths from CSD, 167 of them from ischemic heart disease (IHD) and 105 from CeVD. A nested case-control study was then set up to collect and investigate the influence of these risk factors on the relationships between mortality from CSD and occupational external gamma ray and internal ionizing radiation exposure (radon and long-lived radionuclides) in this updated cohort. The nested case-control study included miners first employed after 1955, still employed in 1976 and followed up through 2007. Individual information about CSD risk factors was collected from medical files for the 76 deaths from CSD (including 26 from IHD and 16 from CeVD) and 237 miners who had not died of CSD by the end of follow-up. The exposure-risk relationships were assessed with a Cox proportional hazard model weighted by the inverse sampling probability. A significant increase in all CSD and CeVD mortality risks associated with radon exposure was observed in the total cohort [hazard ratios: HRCSD/100 working level months (WLM) = 1.11, 95% confidence interval (1.01; 1.22) and HRCeVD/100 WLM = 1.25 (1.09; 1.43), respectively]. A nonsignificant exposure-risk relationship was observed for every type of cumulative ionizing radiation exposure and every end point [e.g., HRCSD/100WLM = 1.43 (0.71; 2.87)]. The adjustment for each CSD risk factor did not substantially change the exposure-risk relationships. When the model was adjusted for overweight, hypertension, diabetes, hypercholesterolemia and smoking status, the HR/100WLM for CSD, for example, was equal to 1.21 (0.54; 2.75); and when it was adjusted for risk factors selected with the

  17. Health workforce development: a needs assessment study in French speaking African countries.

    PubMed

    Chastonay, Philippe; Moretti, Roberto; Zesiger, Véronique; Cremaschini, Marco; Bailey, Rebecca; Pariyo, George; Kabengele, Emmanuel Mpinga

    2013-05-01

    In 2006, WHO alerted the world to a global health workforce crisis, demonstrated through critical shortages of health workers, primarily in Sub-Saharan Africa (WHO in World Health Report, 2006). The objective of our study was to assess, in a participative way, the educational needs for public health and health workforce development among potential trainees and training institutions in nine French-speaking African countries. A needs assessment was conducted in the target countries according to four approaches: (1) Review at national level of health challenges. (2) Semi-directed interviews with heads of relevant training institutions. (3) Focus group discussions with key-informants. (4) A questionnaire-based study targeting health professionals identified as potential trainees. A needs assessment showed important public health challenges in the field of health workforce development among the target countries (e.g. unequal HRH distribution in the country, ageing of HRH, lack of adequate training). It also showed a demand for education and training institutions that are able to offer a training programme in health workforce development, and identified training objectives and core competencies useful to potential employers and future trainees (e.g. leadership, planning/evaluation, management, research skill). In combining various approaches our study was able to show a general demand for health managers who are able to plan, develop and manage a nation's health workforce. It also identified specific competencies that should be developed through an education and training program in public health with a focus on health workforce development.

  18. The Montagne Noire migmatitic dome emplacement (French Massif Central): new insights from petrofabric and AMS studies

    NASA Astrophysics Data System (ADS)

    Charles, Nicolas; Faure, Michel; Chen, Yan

    2009-11-01

    In the southern French Massif Central, the Montagne Noire axial zone is a NE-SW elongated granite-migmatite dome emplaced within Visean south-verging recumbent folds and intruded by syn- to late-migmatization granitoids. The tectonic setting of this dome is still disputed, thus several models have been proposed. In order to better understand the emplacement mechanism of this dome, petrofabric and Anisotropy of Magnetic Susceptibility (AMS) studies have been carried out. In the granites and migmatites that form the dome core, magmatic texture and to a lesser extent weak solid-state texture are dominant. As a paramagnetic mineral, biotite is the main carrier of the magnetic susceptibility. On the basis of 135 AMS sites, the magnetic fabrics appear as independent of the lithology but related to the dome architecture. Coupling our results with previous structural and geochronological studies, allows us to propose a new emplacement model. Between 340-325 Ma, the Palaeozoic series underwent a compressional deformation represented by nappes and recumbent folds involving the thermal event leading to partial melting. Until ˜325-310 Ma, the dome emplacement was assisted by diapiric processes. An extensional event took place at ˜300 Ma, after the emplacement of the late to post-migmatitic granitic plutons. In the northeast side of the dome, a brittle normal-dextral faulting controlled the opening of the Graissessac coal basin.

  19. Cohort Profile: The French Childhood Cancer Survivor Study For Leukaemia (LEA Cohort)

    PubMed Central

    Berbis, Julie; Michel, Gérard; Baruchel, André; Bertrand, Yves; Chastagner, Pascal; Demeocq, François; Kanold, Justyna; Leverger, Guy; Plantaz, Dominique; Poirée, Marilyne; Stephan, Jean-Louis; Auquier, Pascal; Contet, Audrey; Dalle, Jean-Hugues; Ducassou, Stéphane; Gandemer, Virginie; Lutz, Patrick; Sirvent, Nicolas; Tabone, Marie-Dominique; Thouvenin-Doulet, Sandrine

    2015-01-01

    The main aim of the Leucémies de l’Enfant et l’Adolescent (LEA) project (Childhood and Adolescent Leukaemia) is to study the determinants (medical, socioeconomic, behavioural and environmental) of medium- and long-term outcomes of patients treated for childhood acute leukaemia (AL). The LEA study began in 2004 and is based on a French multicentric prospective cohort. Included are children treated for AL since January 1980 (incident and prevalent cases), surviving at month 24 for myeloblastic AL and lymphoblastic AL grafted in first complete remission or at month 48 for lymphoblastic AL not grafted in first complete remission. Information is collected during specific medical visits and notably includes the following data: socioeconomic data, AL history, physical late effects (such as fertility, cardiac function and metabolic syndrome) and quality of life. Data are collected every 2 years until the patient is 20 years old and has had a 10-year follow-up duration from diagnosis or last relapse. Thereafter, assessments are planned every 4 years. In active centres in 2013, eligible patients number more than 3000. The cohort has already included 2385 survivors, with rate of exhaustiveness of almost 80%. Data access can be requested from principal coordinators and must be approved by the steering committee. PMID:24639445

  20. Electronic mail, a new written-language register: a study with French-speaking adolescents.

    PubMed

    Volckaert-Legrier, Olga; Bernicot, Josie; Bert-Erboul, Alain

    2009-03-01

    The aim of this study was to determine the extent to which the linguistic forms used by adolescents in electronic mail (e-mail) differ from those used in standard written language. The study was conducted in French, a language with a deep orthography that has strict, addressee-dependent rules for using second person personal pronouns (unfamiliar and familiar forms). Data were collected from 80 adolescents ages 12 to 15 in a natural situation where they had to introduce themselves by e-mail to two addressees (peer/teacher). Participants were divided into two groups (skilled/unskilled in computer-mediated communication). Their emails contained a large number of orthographic deviations (the most frequent being neographic forms). Participants skilled in computer-mediated communication (CMC) deviated more than unskilled ones did. The number of orthographic deviations was not linked to the participants' standard writing ability. The personal-pronoun data clearly showed that adolescents used the familiar form of 'you' (tu) to address the peer and the unfamiliar form (vous) to address the teacher. We conclude that, for adolescents, e-mail constitutes a distinct written-language register. Nevertheless, the e-mail register seems to follow the pragmatic rules of standard spoken and written interaction.

  1. Usage patterns of aromatherapy among the French general population: A descriptive study focusing on dermal exposure.

    PubMed

    Dornic, N; Ficheux, A S; Roudot, A C; Saboureau, D; Ezzedine, K

    2016-04-01

    Although likely benefits of aromatherapy are well documented, little is known about essential oils consumption and exposure to molecules present in the oils. The aim of our study was to determine usage patterns of 12 types of essential oils among a quite large panel, sorted per sex and quintile of age from birth to 70. A survey was conducted in September 2014 among 1507 French individuals, selected to build a representative panel of the general population. The key point of our study, apart from the fact that it has never been done among general population, was the focus on dermal exposure. Information about types of essential oils used, skin areas exposed, frequencies and quantities were collected. Our work revealed that some sub-populations could be significantly exposed to molecules of toxicological concern, especially in terms of skin sensitization. This work is the first step to assess human exposure to these molecules, and will help safety authorities and risk managers to protect the population.

  2. The utilization of ERTS-1 data for the study of the French Atlantic Littoral. [coastal water and geomorphology

    NASA Technical Reports Server (NTRS)

    Demathieu, P. G.; Verger, F. H.

    1974-01-01

    The French Atlantic Littoral (FRALIT) program uses ERTS-1 data to study coastal geomorphology and waters. ERTS-1 gives an overall picture of the phenomena for the first time due mainly to channel 4 data, but the other channels also contribute valuable complementary data on superficial waters. These studies have already resulted in accurate maps of the mud transported south-westwards from the mouth of the River Loire.

  3. Socioeconomic Indicators Are Independently Associated with Nutrient Intake in French Adults: A DEDIPAC Study.

    PubMed

    Si Hassen, Wendy; Castetbon, Katia; Cardon, Philippe; Enaux, Christophe; Nicolaou, Mary; Lien, Nanna; Terragni, Laura; Holdsworth, Michelle; Stronks, Karien; Hercberg, Serge; Méjean, Caroline

    2016-03-10

    Studies have suggested differential associations of specific indicators of socioeconomic position (SEP) with nutrient intake and a cumulative effect of these indicators on diet. We investigated the independent association of SEP indicators (education, income, occupation) with nutrient intake and their effect modification. This cross-sectional analysis included 91,900 French adults from the NutriNet-Santé cohort. Nutrient intake was estimated using three 24-h records. We investigated associations between the three SEP factors and nutrient intake using sex-stratified analysis of covariance, adjusted for age and energy intake, and associations between income and nutrient intake stratified by education and occupation. Low educated participants had higher protein and cholesterol intakes and lower fibre, vitamin C and beta-carotene intakes. Low income individuals had higher complex carbohydrate intakes, and lower magnesium, potassium, folate and vitamin C intakes. Intakes of vitamin D and alcohol were lower in low occupation individuals. Higher income was associated with higher intakes of fibre, protein, magnesium, potassium, beta-carotene, and folate among low educated persons only, highlighting effect modification. Lower SEP, particularly low education, was associated with lower intakes of nutrients required for a healthy diet. Each SEP indicator was associated with specific differences in nutrient intake suggesting that they underpin different social processes.

  4. Classroom Research: GC Studies of Linoleic and Linolenic Fatty Acids Found in French Fries

    NASA Astrophysics Data System (ADS)

    Crowley, Janice P.; Deboise, Kristen L.; Marshall, Megan R.; Shaffer, Hannah M.; Zafar, Sara; Jones, Kevin A.; Palko, Nick R.; Mitsch, Stephen M.; Sutton, Lindsay A.; Chang, Margaret; Fromer, Ilana; Kraft, Jake; Meister, Jessica; Shah, Amar; Tan, Priscilla; Whitchurch, James

    2002-07-01

    A study of fatty-acid ratios in French fries has proved to be an excellent choice for an entry-level research class. This research develops reasoning skills and involves the subject of breast cancer, a major concern of American society. Analysis of tumor samples removed from women with breast cancer revealed high ratios of linoleic to linolenic acid, suggesting a link between the accelerated growth of breast tumors and the combination of these two fatty acids. When the ratio of linoleic to linolenic acid was approximately 9 to 1, accelerated growth was observed. Since these fatty acids are found in cooking oils, Wichita Collegiate students, under the guidance of their chemistry teacher, decided that an investigation of the ratios of these two fatty acids should be conducted. A research class was structured using a gas chromatograph for the analysis. Separation of linoleic from linolenic acid was successfully accomplished. The students experienced inductive experimental research chemistry as it applies to everyday life. The structure of this research class can serve as a model for high school and undergraduate college research curricula.

  5. The psychiatric report as moral tool: a case study in a French district court.

    PubMed

    Fernandez, Fabrice; Lézé, Samuel

    2014-09-01

    Mental health evaluation within a legal setting is widely seen as a power to judge. The aim of this paper is to challenge this current thesis, which was popularised by Michel Foucault, who encapsulated the notion in a brief sentence: "The sordid business of punishing is thus converted into the fine profession of curing" (Foucault, 2003: 23). On the basis of an ethnography of a French district court (between September 2008 and May 2009, n = 60 trials) including interviews with judges (n = 10) and psychiatrists (n = 10), we study the everyday penal treatment of sexual offenders using psychiatric reports. Our findings show how (i.) the expectations of the judges select the psychiatrists' skills (based on the following criteria for their reports: accessibility of knowledge, singularization and individualization of content) and (ii.) reframe the psychiatric report as a moral tool. The clinical reasoning of forensic psychiatrists in their reports offer moral affordances due to their clinical caution regarding the risk of recidivism (therapeutic and criminological reversal, moral prevention). Both the judges' evaluation and the psychiatrists' clinical authority are shaped by a moral economy of dangerousness, which eclipses the idea of lack of criminal responsibility. In conclusion, we show that these unintended effects are necessarily of interest to most clinical practitioners engaged in work as expert witnesses.

  6. Risks of non-lethal weapon use: case studies of three French victims of stinger grenades.

    PubMed

    Scolan, V; Herry, C; Carreta, M; Stahl, C; Barret, L; Romanet, J P; Paysant, F

    2012-11-30

    The development of non-lethal weapons started in the 1960s. In France, they have been used by the police for about 10 years. We relate the cases of three French women, victims of stinger grenades, non-lethal weapons recently adopted by the French law enforcement to distract and disperse crowds. The three victims presented serious injuries requiring emergency surgical care. One lost her eye. Based on these cases, we discuss the lethal character of these weapons and propose measures to be taken to prevent their dramatic consequences. Although the danger is obviously less than for firearms, stinger grenades are nonetheless potentially lethal and cause serious physical injuries.

  7. Is patient education helpful in providing care for patients with rheumatoid arthritis? A qualitative study involving French nurses.

    PubMed

    Fall, Estelle; Chakroun, Nadia; Dalle, Nathalie; Izaute, Marie

    2013-09-01

    This French study explored nurses' involvement in patient education for patients with rheumatoid arthritis. The study design was qualitative. Semistructured interviews were conducted with 16 hospital nurses. Data analysis was performed according to Giorgi's descriptive phenomenological method, and supported by specific qualitative analysis software (Sphinx). The results showed the important role of hospital nurses in rheumatoid arthritis care. Patient education is a core part of nurses' work, allowing them to give patients information and emotional support. The interviewees displayed skills in helping patients learn to care for themselves. However, patient education mostly concerned patients who are already committed to their health care. Non-adherent patients warrant special attention; their acceptance of their disease, perceptions about disease and treatment, motivation, and autonomy should be specifically addressed. French nurses could benefit from more training, and could be aided by psychologists. Ambulatory services could also be developed for patient education in France, based on examples from other countries.

  8. Lifecourse socioeconomic position and alcohol use in young adulthood: results from the French TEMPO cohort study

    PubMed Central

    Yaogo, Ahmed; Fombonne, Eric; Kouanda, Seni; Lert, France; Melchior, Maria

    2013-01-01

    Aims To examine the relationship between lifetime socioeconomic position and alcohol use in young adults. Methods Study participants (n=1,103, age 22–35 years in 2009) belong to the French TEMPO cohort study and are all offspring of participants of the GAZEL cohort study. Alcohol use was assessed by the WHO AUDIT questionnaire (none, low or intermediate alcohol use, alcohol abuse). Childhood socioeconomic position was measured using parental income through the GAZEL cohort study in 1989 (low: ≤2592€/month vs. Intermediate/high: >2592€/month). Adult socioeconomic position was measured by participants’ educational level (<=high school degree vs. > high school degree). Combining family income and educational attainment, we ascertained participants’ social trajectory (stable high, upward, downward and stable low). Data were analyzed using multinomial regression analyses controlled for demographic, social, psychological and family characteristics. Results Participants’ social trajectory was associated with alcohol abstinence: compared to participants with a stable high social trajectory, those with an upward, downward or low social trajectory were more likely to abstain from alcohol (compared to a stable high social trajectory, sex and age-adjusted ORs: OR=2.22, 95% CI 1.35–3.65 for an upward social trajectory; OR=3.20, 95% CI 1.78–5.73 for a downward social trajectory; OR= 3.27, 95% CI 1.75–6.12 for a stable low social trajectory). Additionally, participants with a downward social trajectory were disproportionately likely to abuse alcohol (sex and age-adjusted OR: 1.48, 95% CI 0.89–2.48). In multivariate analyses, social trajectory remained associated with alcohol abstinence. Conclusions Lifelong socioeconomic position may shape patterns of alcohol use early in life. PMID:23900495

  9. Drug-induced Depression: a Case/Non Case Study in the French Pharmacovigilance Database.

    PubMed

    Lafay-Chebassier, Claire; Chavant, François; Favrelière, Sylvie; Pizzoglio, Véronique; Pérault-Pochat, Marie-Christine

    2015-01-01

    Depression is a complex disorder with heterogeneous clinical anomalies whose neurobiological understanding still remains unclear. Medications have been implicated as potential causes of depression but for many of them, data are controversial. The present study aims to investigate association bet ween drugs and reports of depression. We used the case/non case method in the French pharmacovigilance database (FPVD) to identify drugs associated with depression. Cases were reports of depression in the FPVD between January 2007 and December 2011. Non cases were all other reports during the same period. Data were expressed as reporting odds ratio (ROR) with their 95% confidence interval. Of the 114,692 reports recorded in the FPVD during the studied period, we identified 474 cases of depression. For the majority of the patients, they were considered as "non serious" (56%) and evolution was favorable (64%). Significant RORs were found for antiepileptics (topiramate, levetiracetam), anti-infective and especially anti-retroviral drugs (efavirenz, emtricitabine, tenofovir, etravirine, raltegravir), interferons and other agents including isotretinoin, methylphenidate, sodium oxybate, varenicline, montelukast, flunarizine, adalimumab, anastrozole. Taking into account the limits of the methodology, the present study described associations with mainly expected drugs belonging to various therapeutic classes but it also found a signal with some anti-retrovirals. On the contrary, we did not find some assumed associations like cardiovascular medications, antimalarial. For most of the drugs, one or more mechanisms were found to explain these depressogenic effects on the basis of animal and human literature. Even if such associations need to be confirmed by further prospective studies, cautions are necessary for many drugs to early detect depressive symptoms.

  10. RECONSTRUCTION OF INDIVIDUAL RADIATION DOSES FOR A CASE-CONTROL STUDY OF THYROID CANCER IN FRENCH POLYNESIA

    PubMed Central

    Drozdovitch, Vladimir; Bouville, André; Doyon, Françoise; Brindel, Pauline; Cardis, Elisabeth; de Vathaire, Florent

    2014-01-01

    Forty-one atmospheric nuclear weapons tests (plus five safety tests) were conducted in French Polynesia between 1966 and 1974. To evaluate the potential role of atmospheric nuclear weapons testing on a high incidence of thyroid cancer observed since 1985 in French Polynesia, a population-based case-control study was performed. The study included 602 subjects, either cases or controls, all aged less than 40 y at the end of nuclear weapons testing in 1974. Radiation doses to the thyroids of the study subjects were assessed based on the available historical results of radiation measurements. These were mainly found in the annual reports on the radiological situation in French Polynesia that had been sent to the UNSCEAR Secretariat. For each atmospheric nuclear weapons test that contributed substantially to the local deposition of radionuclides, the radiation dose to the thyroid from 131I intake was estimated. In addition, thyroid doses from the intake of short-lived radioiodines (132I, 133I, 135I) and 132Te, external exposure from gamma-emitted radionuclides deposited on the ground, and ingestion of long-lived 137Cs were reconstructed. The mean thyroid dose among the study subjects was found to be around 3 mGy while the highest dose was estimated to be around 40 mGy. Doses from short-lived iodine and tellurium isotopes ranged up to 10 mGy. Thyroid doses from external exposure ranged up to 3 mGy, while those from internal exposure due to cesium ingestion did not exceed 1 mGy. The dose estimates that have been obtained are based on a rather limited number of radiation measurements performed on a limited number of islands and are highly uncertain. A thorough compilation of the results of all radiation monitoring that was performed in French Polynesia in 1966–1974 would be likely to greatly improve the reliability and the precision of the dose estimates. PMID:18403963

  11. A cross-linguistic study of the development of gesture and speech in Zulu and French oral narratives.

    PubMed

    Kunene Nicolas, Ramona; Guidetti, Michèle; Colletta, Jean-Marc

    2017-01-01

    The present study reports on a developmental and cross-linguistic study of oral narratives produced by speakers of Zulu (a Bantu language) and French (a Romance language). Specifically, we focus on oral narrative performance as a bimodal (i.e., linguistic and gestural) behaviour during the late language acquisition phase. We analyzed seventy-two oral narratives produced by L1 Zulu and French adults and primary school children aged between five and ten years old. The data were all collected using a narrative retelling task. The results revealed a strong effect of age on discourse performance, confirming that narrative abilities improve with age, irrespective of language. However, the results also showed cross-linguistic differences. Zulu oral narratives were longer, more detailed, and accompanied by more co-speech gestures than the French narratives. The parallel effect of age and language on gestural behaviour is discussed and highlights the importance of studying oral narratives from a multimodal perspective within a cross-linguistic framework.

  12. Possible causes of variation in acrylamide concentration in French fries prepared in food service establishments: an observational study.

    PubMed

    Sanny, M; Jinap, S; Bakker, E J; van Boekel, M A J S; Luning, P A

    2012-05-01

    Acrylamide is a probable human carcinogen, and its presence in a range of fried and oven-cooked foods has raised considerable health concern world-wide. Dietary intake studies observed significant variations in acrylamide concentrations, which complicate risk assessment and the establishment of effective control measures. The objective of this study was to obtain an insight into the actual variation in acrylamide concentrations in French fries prepared under typical conditions in a food service establishment (FSE). Besides acrylamide, frying time, frying temperature, and reducing sugars were measured and the actual practices at receiving, thawing and frying during French fries preparation were observed and recorded. The variation in the actual frying temperature contributed most to the variation in acrylamide concentrations, followed by the variation in actual frying time; no obvious effect of reducing sugars was found. The lack of standardised control of frying temperature and frying time (due to inadequate frying equipment) and the variable practices of food handlers seem to contribute most to the large variation and high acrylamide concentrations in French fries prepared in a restaurant type of FSE as compared to chain fast-food services, and institutional caterers. The obtained insights in this study can be used to develop dedicated control measures in FSE, which may contribute to a sustainable reduction in the acrylamide intake.

  13. Technical Objects between Categorisation and Learning: An Exploratory Case Study in French Middle School

    ERIC Educational Resources Information Center

    Impedovo, M. A.; Andreucci, C.; Delserieys-Pedregosa, A.; Coiffard, C.; Ginestié, J.

    2015-01-01

    In this article we present exploratory research carried out in order to understand how students (from 12 to 14 years old) relate to technical objects. It uses technical objects that are part of everyday life and mediated reality. A questionnaire was administered to 57 students in French classes. The questionnaire was composed of three parts: 1)…

  14. Individual and contextual covariates of burnout: a cross-sectional nationwide study of French teachers

    PubMed Central

    Vercambre, Marie-Noël; Brosselin, Pauline; Gilbert, Fabien; Nerrière, Eléna; Kovess-Masféty, Viviane

    2009-01-01

    Background Limited information on the covariates of burnout syndrome in French teachers is available. The aim of this study was to evaluate the relative contributions of individual and contextual factors on the three burnout dimensions: emotional exhaustion, depersonalization, and reduced personal accomplishment. Methods The source data come from an epidemiological postal survey on physical and mental health conducted in 2005 among 20,099 education workers (in activity or retired) selected at random from the health plan records of the national education system. The response rate was 52.4%. Teachers in activity currently giving classes to students who participated in the survey (n = 3,940) were invited to complete a self-administered questionnaire including the Maslach Burnout Inventory. 2,558 teachers provided complete data (64.9%). Variables associated with high emotional exhaustion (highest quartile of score), high depersonalization (highest quartile), and reduced personal accomplishment (lowest quartile) were evaluated using multivariate logistic regression. Studied variables referred to demographic characteristics, socio-professional environment, job dissatisfaction, experienced difficulties at work, and teaching motivations. Results Different variables were associated with each burnout dimension. Female teachers were more susceptible to high emotional exhaustion and reduced personal accomplishment, whereas male teachers were more susceptible to high depersonalization. Elementary school teachers were more susceptible to high emotional exhaustion, but less susceptible to high depersonalization and reduced personal accomplishment than their higher school level counterparts. Experienced difficulties with pupils were associated with all three dimensions. A socio-economically underprivileged school neighbourhood was also related to high emotional exhaustion and high depersonalization. Conclusion Programs to enhance teaching environment might be an interesting

  15. Drug-induced progressive multifocal leukoencephalopathy: a case/noncase study in the French pharmacovigilance database.

    PubMed

    Colin, Olivier; Favrelière, Sylvie; Quillet, Alexandre; Neau, Jean-Philippe; Houeto, Jean-Luc; Lafay-Chebassier, Claire; Pérault-Pochat, Marie-Christine

    2017-04-01

    Progressive multifocal leukoencephalopathy (PML) is an often fatal demyelinating disease of the central nervous system. As effective treatment is unavailable, identification of all drugs that could be associated with PML is essential. The objective of this study was to investigate the putative association of reports of PML and drugs. We used the case/noncase method in the French PharmacoVigilance database (FPVD). Cases were reports of PML in the FPVD between January 2008 and December 2015. Noncases were all other reports during the same period. To assess the association between PML and drug intake, we calculated an adverse drug report odds ratio (ROR) with its 95% confidence interval. We have studied the delay of onset of PML for each drug concerned. Among the 101 cases of PML, 39 drugs were mentioned as suspect. The main therapeutic classes suspected with significant ROR were antineoplastic agents (n = 85), immunosuppressants (n = 67), and corticosteroids. A latent interval from the time of drug initiation to the development of PML is established: the median time to onset was 365 days (123-1095 days). The onset of PML is highly variable and differs among drug classes [from 1 to 96 months (IQR: 39.0-126)]. An association between PML and some immunosuppressant drugs was found as expected, but also with antineoplastic agents and glucocorticoids. An important delay of PML onset after stopping treatment is suspected and should alert prescribers. Prescribers but also patients should be informed about the potential associations with all these drugs. Monitoring could be necessary for many drugs to early detect PML.

  16. Chromosome 11-q24 region in Tourette syndrome: association and linkage disequilibrium study in the French Canadian population.

    PubMed

    Díaz-Anzaldúa, Adriana; Rivière, Jean-Baptiste; Dubé, Marie-Pierre; Joober, Ridha; Saint-Onge, Judith; Dion, Yves; Lespérance, Paul; Richer, Francois; Chouinard, Sylvain; Rouleau, Guy Armand

    2005-10-15

    Previous studies have found association and linkage between Tourette syndrome (TS) and markers at the 11q24 region, mainly with markers D11S1377 and D11S933. In order to determine if these positive findings could be replicated in our sample, we undertook a family-based association study in 199 French Canadian TS nuclear families. We genotyped 572 individuals from 174 complete and 25 incomplete TS trios. TDT analysis failed to detect an association between TS and six markers from 11q24. Furthermore, no haplotype combining alleles from D11S1377, D11S933, or any of the other four markers was associated with the disorder. Linkage disequilibrium analysis showed evidence of historical recombination between every contiguous pair of markers, indicating that these genetic variants are probably in equilibrium in the French Canadian population. Further analysis in additional families, with different methodologies (linkage and association) will be required in order to determine if the 11q24 region harbors a susceptibility locus for TS. If it does, this defect may not be frequent in the French Canadian population due to locus heterogeneity.

  17. A comparison study of Zika virus outbreaks in French Polynesia, Colombia and the State of Bahia in Brazil.

    PubMed

    He, Daihai; Gao, Daozhou; Lou, Yijun; Zhao, Shi; Ruan, Shigui

    2017-03-21

    Zika virus (ZIKV) disease outbreaks occurred in French Polynesia in 2013-2014 and in Brazil and Colombia in 2015-2016, respectively. Using our recently developed ZIKV disease model, we simulated the reported ZIKV infection cases from French Polynesia, Colombia and the State of Bahia of Brazil. Moreover, we estimated that the infection attack rates were 78.0% (95% confidence interval (CI): 63.5-86.3%) in French Polynesia which closely matches a previous serological study; 20.8% (95% CI: 1.1-50.0%) in Colombia which suggests that the attack rate was most likely less than 50%; and 32.4% (95% CI: 2.5-94.2%) in the State of Bahia in Brazil which suggests that the attack rate is unidentifiable with monthly data in Bahia. Furthermore, we found that the association of precipitation and ZIKV outbreak was more evident in Colombia than the other two places. These results are helpful for us to understand the possible evolution, to control the on-going outbreaks, to prevent the potential geographic spread, and to study the ecological and epidemiological characteristics of ZIKV.

  18. Mastocytosis among elderly patients: A multicenter retrospective French study on 53 patients.

    PubMed

    Rouet, Audrey; Aouba, Achille; Damaj, Gandhi; Soucié, Erinn; Hanssens, Katia; Chandesris, Marie-Olivia; Livideanu, Cristina Bulai; Dutertre, Marine; Durieu, Isabelle; Grandpeix-Guyodo, Catherine; Barète, Stéphane; Bachmeyer, Claude; Soria, Angèle; Frenzel, Laurent; Fain, Olivier; Grosbois, Bernard; de Gennes, Christian; Hamidou, Mohamed; Arlet, Jean-Benoit; Launay, David; Lavigne, Christian; Arock, Michel; Lortholary, Olivier; Dubreuil, Patrice; Hermine, Olivier; Georgin-Lavialle, Sophie

    2016-06-01

    Mastocytosis is a heterogeneous group of diseases with a young median age at diagnosis. Usually indolent and self-limited in childhood, the disease can exhibit aggressive progression in mid-adulthood. Our objectives were to describe the characteristics of the disease when diagnosed among elderly patients, for which rare data are available.The French Reference Center conducted a retrospective multicenter study on 53 patients with mastocytosis >69 years of age, to describe their clinical, biological, and genetic features.The median age of our cohort of patients was 75 years. Mastocytosis variants included were cutaneous (n = 1), indolent systemic (n = 5), aggressive systemic (n = 11), associated with a hematological non-mast cell disease (n = 34), and mast cell leukemia (n = 2). Clinical manifestations were predominantly mast cell activation symptoms (75.5%), poor performance status (50.9%), hepatosplenomegaly (50.9%), skin involvement (49.1%), osteoporosis (47.2%), and portal hypertension and ascites (26.4%). The main biological features were anemia (79.2%), thrombocytopenia (50.9%), leucopenia (20.8%), and liver enzyme abnormalities (32.1%). Of the 40 patients tested, 34 (85%), 2 (5%), and 4 (10%) exhibited the KIT D816V mutant, other KIT mutations and the wild-type form of the KIT gene, respectively. Additional sequencing detected significant genetic defects in 17 of 26 (65.3%) of the patients with associated hematological non-mast cell disease, including TET2, SRSF2, IDH2, and ASLX1 mutations. Death occurred in 19 (35.8%) patients, within a median delay of 9 months, despite the different treatment options available.Mastocytosis among elderly patients has a challenging early detection, rare skin involvement, and/or limited skin disease; it is heterogeneous and has often an aggressive presentation with nonfortuitous associated myeloid lineage malignant clones, and thus a poor overall prognosis.

  19. Acidosis and nutritional status in hemodialyzed patients. French Study Group for Nutrition in Dialysis.

    PubMed

    Chauveau, P; Fouque, D; Combe, C; Laville, M; Canaud, B; Azar, R; Cano, N; Aparicio, M; Leverve, X

    2000-01-01

    In a cross-sectional study of more than 30% of French dialysis patients (N = 7,123), we evaluated the relationships between predialysis plasma bicarbonate concentration and nutritional markers. Data including age, gender, cause of end-stage renal disease (ESRD), time on dialysis, body mass index (BMI), blood levels of midweek predialysis albumin, prealbumin, and bicarbonate were collected. Normalized protein catabolic rate (nPCR), dialysis adequacy parameters, and estimation of lean body mass (LBM) were computed from pre- and postbicarbonate-dialysis urea and creatinine levels according to the classical formulas of Garred. Average values (+/- 1 SD) were age 61 +/- 16 years, BMI 23.3 +/- 4.6 kg/m2, dialysis time 12.4 +/- 2.7 h/week, HCO3 22.8 +/- 3.5 mmol/L, albumin 38.7 +/- 5.3 g/L, prealbumin 340 +/- 90 mg/L, Kt/V 1.36 +/- 0.36, nPCR 1.13 +/- 0.32 g/kg BW/day, and LBM 0.86 +/- 0.21% of ideal LBM. A highly significant negative correlation was observed between predialysis bicarbonate levels (within a range of 16-30 mmol/L, 95% of this population) and nPCR confirmed by analysis of variance using bicarbonate classes (p < 0.0001). Bicarbonate was also negatively correlated with albumin, prealbumin, BMI, and LBM. No relationship was noted between bicarbonate and Kt/V despite a positive correlation between Kt/V and nPCR. It is likely that a persistent acidosis observed despite standard bicarbonate dialysis was caused by a high dietary protein intake which results in an increased acid load, but also overcomes the usual catabolic effects of acidosis.

  20. Hereditary angioedema and lupus: A French retrospective study and literature review.

    PubMed

    Gallais Sérézal, Irène; Bouillet, Laurence; Dhôte, Robin; Gayet, Stéphane; Jeandel, Pierre-Yves; Blanchard-Delaunay, Claire; Martin, Ludovic; Mekinian, Arsène; Fain, Olivier

    2015-06-01

    Hereditary angioedema (HAE) is a rare genetic disorder that is primarily caused by a defect in the C1 inhibitor (C1-INH). The recurrent symptoms are subcutaneous edema and abdominal pain. Laryngeal edema, which can also occur, is life threatening if it goes untreated. HAE can be associated with some inflammatory and autoimmune disorders, particularly lupus. The aim of this study was to describe cases of lupus among HAE patients in France and to perform a literature review of lupus and HAE studies. Case detection and data collection (a standardized form) were performed, thanks to the French Reference Center for Kinin-related angioedema. Data were collected from 6 patients with type 1 HAE and lupus in France; no cases of systemic lupus erythematosus were reported. In the literature review, 32 cases of lupus combined with HAE were identified, including 26 female patients. The median patient age at the time of first reported HAE symptoms and at diagnosis were 17.5 years (range, 9-41 years) and 19 years (range, 9-64 years), respectively for our 6 patients and 14 years (range, 3-30 years) and 17 years (range, 7-48 years), respectively, for the literature review. The clinical manifestations of HAE were mainly abdominal pain (83% in our patients vs 47% in the literature) and edema of the limbs (83% vs 38%). The C4 levels were low (for 100% of our cases vs 93% in the literature). Eighteen patients in the literature demonstrated HAE symptoms prior to the lupus onset vs 5 for our patients. The mean patient age at lupus onset was 20 years (range, 13-76 years) for our patients and 19.5 years (range, 1-78 years) in the literature, respectively. In the literature, 81% of the patients had skin manifestations, 25% had renal involvement and 28% received systemic steroids to treat lupus. Treatment with danazol did not modify the clinical expression of lupus. The association between lupus and HAE is a rare but not unanticipated event. Patients are often symptomatic for HAE before

  1. An Empirical Study of Readers' Associations with Multilingual Advertising: The Case of French, German and Spanish in Dutch Advertising

    ERIC Educational Resources Information Center

    Hornikx, Jos; van Meurs, Frank; Starren, Marianne

    2007-01-01

    In multilingual advertising, a foreign language is often used for symbolic purposes. In non-French-speaking countries, for instance, French is said to be associated with charm and style. The assumption is that the associations carried by the foreign language are transferred to the product that is advertised. A product advertised using French would…

  2. Breast cancer subtype of French women is not influenced by socioeconomic status: A population-based-study

    PubMed Central

    Auguste, Aviane; Cortet, Marion; Dabakuyo-Yonli, Tienhan Sandrine; Launay, Ludivine; Arnould, Laurent; Desmoulins, Isabelle; Roignot, Patrick; Darut-Jouve, Ariane; Poillot, Marie-Laure; Bertaut, Aurélie; Arveux, Patrick

    2017-01-01

    Context The molecular subtype of breast tumours plays a major role in cancer prognosis and treatment options. Triple negative tumours (TN) carry the worst prognosis and affects most frequently women of low socioeconomic status (SES). Studies have shown that non-biologic factors, such as the socioeconomic status could have an influence on tumour biology. To this date no study has been done investigating this association in French women. The objective is to study the association between the SES and the molecular tumour subtype of breast cancer patients in the French county of Côte d’Or. This study benefits from the population data from the Côte d’Or breast cancer registry known for its strict quality control policy. Methods Invasive breast cancer cases between 2003 and 2013 were extracted from the Breast cancer registry database in Côte d’Or. A multivariate analysis was conducted using a hierarchical polytomous regression for the multinomial outcomes for the cancer subtype with HR+/HER2 as reference category. Results A total of 4553 cases were included in our study. There was no significant association found between SES and tumour subtype in French women at diagnosis. Women older than 75 years were less likely to have a TN and HR+/HER2+ breast cancer (OR = 0.66; CI95% = [0.46–0.94] and OR = 0.51; CI95% = [0.37–0.70] respectively). Women with TN tumour subtype had significantly less lymph node invasion when compared to HR+/HER2- subtype (OR = 0.71; CI95% = [0.54–0.92]). Conclusion No significant association was found between socioeconomic status and molecular subtype. Further studies are needed to clarify the mechanisms associated with developing each tumour subtype. PMID:28199325

  3. Old French for Undergraduates.

    ERIC Educational Resources Information Center

    Sargent, Barbara Nelson

    A list of six main benefits of the study of Old French at the undergraduate level follows a discussion of the value, function, and goals of such a program. The advantages discussed result in: (1) a first-hand acquaintance with medieval masterpieces, (2) a sense of continuity in the history of literature, (3) improved techniques in critical…

  4. Combined adverse effects of cascading events on systems' functionality: an insular case study, French West Indies

    NASA Astrophysics Data System (ADS)

    Desramaut, Nicolas; Wang, Justin; Gehl, Pierre; Marti, Jose; Baills, Audrey; Reveillere, Arnaud

    2013-04-01

    In our modern societies, lifelines play a vital role, even in normal conditions. Therefore, during crises, the dependency to critical infrastructures is likely to be exacerbated. Indeed, in order to provide quick emergency services to the population, systems have to be functional. However, even if not directly damaged, in order to be functional, elements of the different systems have to receive enough resources but also to be able to supply their own services. In a multi-risk approach, this necessity to take into account systemic vulnerability to assess the real impact of natural hazards on society is even made more obvious. For example, impacts of one hazard, taken separately, might not significantly affect societies, but might reduce redundancy, and therefore could increase functional vulnerability to other hazards. The present study aims at analyzing the effects of cascading events on the behaviour of interdependent systems and on the capacities of the health care system to treat the victims. In order to work on a close system, an insular context (Guadeloupe, French West Indies) has been selected. The hazard cascading scenario consists of a M6.3 earthquake striking Basse-Terre, and triggering landslides in the mountainous areas where antecedent precipitations have made the area prone to slide. Damages due to earthquakes have been estimated for the 5 considered systems (buildings, healthcare system, electrical network, water supply network and transportation). Due to their localization in mountainous areas, landslides would affect only transportation networks, with closure of roads. The inter- and intra-dependencies of systems have been modeled thanks to the I2Sim platform developed at UBC. The functionality of each element is therefore the consequence of the physical (direct damage) but also functional (indirect) damage. Analyses are performed for different strategies of resources allocations, and one of the final results is the impact of the induced landslides

  5. Chemoprophylaxis and treatment of African canine trypanosomosis in French military working dogs: a retrospective study.

    PubMed

    Watier-Grillot, Stéphanie; Herder, Stéphane; Marié, Jean-Lou; Cuny, Gérard; Davoust, Bernard

    2013-05-01

    African trypanosomosis is a major threat to livestock production in sub-Saharan Africa. Although the disease mainly concerns cattle, dogs can also be infected by Trypanosoma spp. transmitted by tsetse flies. Between 1997 and 2003, the parasite Trypanosoma congolense was identified in French military dogs sent to Africa. On infected dogs, the diagnosis was made during the mission or just after the return to France, depending on when the symptoms appeared. The high incidence and mortality rate among these dogs led veterinarians of the French Health Service to implement a systematic chemoprophylaxis beginning in 2004. Between 2004 and 2011, the chemoprophylaxis was carried out on more than 400 military dogs. The protocol of chemoprophylaxis relies on the use of isometamidium chloride (Trypamidium(®), Merial). The drug has been used successfully at the dosage of 1mg/kg body weight by deep intramuscular injection, every two or three months. In addition, dogs are given collars impregnated with deltamethrin (Scalibor(®), MSD Animal Health). Isometamidium chloride was also used successfully in the treatment of military dogs infected with T. congolense, with a full recovery and without any relapses.

  6. Research Perspectives on Core French: A Literature Review

    ERIC Educational Resources Information Center

    Lapkin, Sharon; Mady, Callie; Arnott, Stephanie

    2009-01-01

    This article reviews the research literature on core French in three main areas: student diversity, delivery models for the core French program, and instructional approaches. These topics are put into context through a discussion of studies on community attitudes to French as a second language (FSL), dissatisfaction with core French outcomes and…

  7. A validation study of memory and executive functions indexes in French-speaking healthy young and older adults.

    PubMed

    Fortin, Alexandra; Caza, Nicole

    2014-03-01

    Medial temporal lobe (MTL)/memory and frontal lobe (FL)/executive functions indexes are used to measure changes related to cognitive aging. These indexes are based on composite scores of neuropsychological tests validated in English-speaking populations, and their use in aging research is growing in popularity. This study aimed at validating the MTL/memory and FL/executive functions indexes in French-speaking adults. Ninety-eight healthy participants (32 young and 66 older adults) were tested on eight neuropsychological tests, three associated with MTL/memory functions and five associated with FL/executive functions. Factor analysis indicated that residual scores independent of age and associated with MTL/memory functions grouped under one factor, and residual scores associated with FL/executive functions grouped under another factor. Bootstrapping analysis with 1,000 resamples confirmed stability for seven neuropsychological tests. This study provides the first validation of the MTL/memory and FL/executive functions composite scores in French-speaking adults, which may be used to assess cognitive changes in aging research.

  8. Dengue seroprevalence in the French West Indies: a prospective study in adult blood donors.

    PubMed

    L'Azou, Maïna; Jean-Marie, Janick; Bessaud, Maël; Cabié, André; Césaire, Raymond; de Lamballerie, Xavier; Courbil, Rémi; Richard, Pascale

    2015-06-01

    Using an anti-dengue immunoglobulin G (IgG) indirect enzyme-linked immunosorbent assay, seroprevalence was determined among 783 adult blood donors in the French Caribbean islands of Guadeloupe and Martinique in 2011. Overall, 93.5% [91.5; 95.1] samples were positive for dengue antibodies, 90.7% (350 of 386) in Martinique and 96.2% (382 of 397) in Guadeloupe. Only 30% of these adults recalled having had dengue disease before. Serotype-specific neutralization assays applied to a subset of IgG-positive samples indicated that a majority (77 of 96; 80%) reacted to the four serotypes. These seroprevalence findings are the first reported for Guadeloupe and Martinique and are consistent with the dengue epidemiology in these territories.

  9. Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors

    PubMed Central

    L'Azou, Maïna; Jean-Marie, Janick; Bessaud, Maël; Cabié, André; Césaire, Raymond; de Lamballerie, Xavier; Courbil, Rémi; Richard, Pascale

    2015-01-01

    Using an anti-dengue immunoglobulin G (IgG) indirect enzyme-linked immunosorbent assay, seroprevalence was determined among 783 adult blood donors in the French Caribbean islands of Guadeloupe and Martinique in 2011. Overall, 93.5% [91.5; 95.1] samples were positive for dengue antibodies, 90.7% (350 of 386) in Martinique and 96.2% (382 of 397) in Guadeloupe. Only 30% of these adults recalled having had dengue disease before. Serotype-specific neutralization assays applied to a subset of IgG-positive samples indicated that a majority (77 of 96; 80%) reacted to the four serotypes. These seroprevalence findings are the first reported for Guadeloupe and Martinique and are consistent with the dengue epidemiology in these territories. PMID:25846291

  10. [Breast augmentation by implants: a review of surgical practices. A study among French plastic surgeons].

    PubMed

    Chekaroua, K; Delay, E

    2005-10-01

    In the framework of the 2005 report on mammary implants prepared by the Société française de chirurgie plastique reconstructrice et esthétique (SOF.CPRE), we conducted a survey among french plastic surgeons involved in the field. We elaborated a questionnaire that we distributed twice to the 600 members of the society; a total of 261 responded. Analysis of the data collected provides information on the socioprofessional characteristics of the responding surgeons, and on the devices, products and techniques they use. Finally, the survey has permitted to identify their qualitative perception of breast implant products currently available. Ranking these items by order of frequency provides a snapshot of the current procedures and practices in use for breast augmentation surgery in France.

  11. Vigie-Ciel : a french citizen network to study meteors and meteorites

    NASA Astrophysics Data System (ADS)

    Bouley, S.; Zanda, B.; Colas, F.; Vaubaillon, J.; Marmo, C.; Vernazza, P.; Gattacceca, J.

    2013-12-01

    Vigie Ciel is a french citizen network supported by the Muséum National d'Histoire Naturelle (MNHN) and the Université Paris-Sud (UPsud). It is based on the scientific FRIPON program developed by Paris Observatory (Fireball Recovery and Planetary Inter Observation Network) which has for main goal to (i) determine the source region(s) of the various meteorite classes, (ii) collect both fresh and rare meteorite types and (iii) perform scientific outreach. This will be achieved by building the densest camera network in the world, based on state of the art technologies and associated with a participative network for meteorite recovery. We propose to install a network of 100 digital cameras covering the entire French territory to compute impact locations with accuracy of the order of one kilometer. Considering that there are 5 to 25 falls over France per year (~15 on average), during the same time, we will observe ~50 falls out of which we realistically expect to find 10 meteorites. Our project is original in several ways. (i) It is inter-disciplinary, involving experts in meteoritics, asteroidal science as well as fireball observation and dynamics. It will thus create new synergies between prominent institutions and/or laboratories, namely between MNHN, Paris Observatory and Université Paris-Sud in the Parisian region; and between CEREGE and LAM in the Provence region. Overall, scientists from over 25 laboratories will be involved, covering a mix of scientific disciplines and all the regions of France. (ii) It will generate a large body of data, feeding databases of interest to several disciplines (e.g. bird migration, variations of the luminosity of the brightest stars, observation of space debris, meteorology...). (iii) It will for the first time involve the general public (including schools) in the search for the meteorite falls, thus boosting the interest in meteorite and asteroid related science.

  12. [Exploratory study of amitriptyline resistance in depressed patients: results of WHO French collaborating center on depressions resistant to treatments].

    PubMed

    Loas, G; Rose, D; Nowaczkowski, P; Lernout, P; Duron, B

    1996-06-01

    A multicountry, multicentre double-blind study in a group of depressives, coordinated by the Mental Health Division of the World Health Association (WHO) has been done. The goal of the study is to determine whether the therapeutic effects of amitriptyline can be enhanced and potentiated by combining it with an antioxydant (gingko biloba). An exploratory study has preceded the main study which had the objective to estimate the proportion of non-response patient to amitriptyline. We report the results concerning the French center. 23 inpatients meet the ICD-10 criteria for depression (F32 and F33) and were treated during 6 weeks by amitriptyline with the initial daily dose of 50 mg until the maximum dose of 200 mg. The proportion of non-responsive patient to amitriptyline was 34.78 (95% confidence interval : 15.32 to 54.24%), all clinically deteriorated.

  13. Resveratrol: French Paradox Revisited

    PubMed Central

    Catalgol, Betul; Batirel, Saime; Taga, Yavuz; Ozer, Nesrin Kartal

    2012-01-01

    Resveratrol is a polyphenol that plays a potentially important role in many disorders and has been studied in different diseases. The research on this chemical started through the “French paradox,” which describes improved cardiovascular outcomes despite a high-fat diet in French people. Since then, resveratrol has been broadly studied and shown to have antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic effects, with those on oxidative stress possibly being most important and underlying some of the others, but many signaling pathways are among the molecular targets of resveratrol. In concert they may be beneficial in many disorders, particularly in diseases where oxidative stress plays an important role. The main focus of this review will be the pathways affected by resveratrol. Based on these mechanistic considerations, the involvement of resveratrol especially in cardiovascular diseases, cancer, neurodegenerative diseases, and possibly in longevity will be is addressed. PMID:22822401

  14. Use of the Foreign Studies: Transposition of the Results, Prediction of the Therapeutic Effects in the French Population, Modelling of the Public Health Interest.

    PubMed

    Massol, Jacques; Zylberman, Myriam; Goehrs, Jean-Marie

    2006-01-01

    More and more frequently, the health authorities and the French assessment agencies are led to issue Marketing Authorizations (MAs), give opinions on the eligibility for reimbursement of drugs or to draft recommendations for clinical practice based on the results of foreign studies. The results of these studies are more or less difficult to transpose to French practice. These difficulties generate varying degrees of uncertainty concerning the effect to be expected of a drug. A more or less extensive loss of effect is sometimes even predictable. Some of the difficulties in transposition are discussed in this article and proposals for action are made in order to allow one, in the long term, to predict in the most precise manner possible the effects to be expected from a drug in the French population and be able to verify this prediction at an interval from its eligibility for reimbursement.

  15. Realisation of voicing by French-speaking CI children after long-term implant use: An acoustic study.

    PubMed

    Grandon, Bénédicte; Vilain, Anne; Lœvenbruck, Hélène; Schmerber, Sébastien; Truy, Eric

    2017-03-31

    Studies of speech production in French-speaking cochlear-implanted (CI) children are very scarce. Yet, difficulties in speech production have been shown to impact the intelligibility of these children. The goal of this study is to understand the effect of long-term use of cochlear implant on speech production, and more precisely on the coordination of laryngeal-oral gestures in stop production. The participants were all monolingual French children: 13 6;6- to 10;7-year-old CI children and 20 age-matched normally hearing (NH) children. We compared /p/, /t/, /k/, /b/, /d/ and /g/ in word-initial consonant-vowel sequences, produced in isolation in two different tasks, and we studied the effects of CI use, vowel context, task and age factors (i.e. chronological age, age at implantation and duration of implant use). Statistical analyses show a difference in voicing production between groups for voiceless consonants (shorter Voice Onset Times for CI children), with significance reached only for /k/, but no difference for voiced consonants. Our study indicates that in the long run, use of CI seems to have limited effects on the acquisition of oro-laryngeal coordination needed to produce voicing, except for specific difficulties located on velars. In a follow-up study, further acoustic analyses on vowel and fricative production by the same children reveal more difficulties, which suggest that cochlear implantation impacts frequency-based features (second formant of vowels and spectral moments of fricatives) more than durational cues (voicing).

  16. Selected Essays and Curriculum Units: Foreign Language Instruction through the Study of Literary Texts. French, German, Spanish.

    ERIC Educational Resources Information Center

    Silber, Ellen S., Ed.; Krug, Clara, Ed.

    This guide presents essays and curriculum units designed for use by secondary and college teachers of French, German, and Spanish as a foreign language. The first section of the work includes two essays, in French, and eight curriculum units based on the stories of Guy de Maupassant. The second section contains seven curriculum units that…

  17. A Comparative Study of the Academic Performance of Secondary School Pupils at Grade Twelve Level in English, French and Zambian Languages (1998-2008)

    ERIC Educational Resources Information Center

    Chishiba, G. M.; Mukuka, Joseph

    2012-01-01

    The study compared the performance of pupils at grade 12 level in Zambian languages, French and English during a period of ten years (1998-2008). Grade 12 is the final year of Secondary School Education in Zambia. This exercise was aimed at establishing the language with the best performance during the aforementioned period. The study, which was…

  18. Ciguatera risk management in French Polynesia: the case study of Raivavae Island (Australes Archipelago).

    PubMed

    Chinain, Mireille; Darius, H Taiana; Ung, André; Fouc, Mote Tchou; Revel, Taina; Cruchet, Philippe; Pauillac, Serge; Laurent, Dominique

    2010-10-01

    Based on epidemiological data available through long-term monitoring surveys conducted by both the Public Health Directorate and the Louis Malardé Institute, ciguatera is highly endemic in French Polynesia, most notably in Raivavae (Australes) which appears as a hot spot of ciguatera with an average incidence rate of 140 cases/10,000 population for the period 2007-2008. In order to document the ciguatera risk associated with Raivavae lagoon, algal and toxin-based field monitoring programs were conducted in this island from April 2007 to May 2008. Practically, the distribution, abundance and toxicity of Gambierdiscus populations, along with the toxicity levels in 160 fish distributed within 25 distinct species, were assessed in various sampling locations. Herbivores such as Scarids (parrotfish) and Acanthurids (unicornfish) were rated as high-risk species based on receptor-binding assay toxicity data. A map of the risk stratification within the Raivavae lagoon was also produced, which indicates that locations where both natural and man-made disturbances have occurred remained the most susceptible to CFP incidents. Our findings also suggest that, locally, the traditional knowledge about ciguatera may not be scientifically complete but is functionally correct. Community education resulted in self-regulating behaviour towards avoidance of high-risk fish species and fishing locations.

  19. Acute clinical events in 299 homozygous sickle cell patients living in France. French Study Group on Sickle Cell Disease.

    PubMed

    Neonato, M G; Guilloud-Bataille, M; Beauvais, P; Bégué, P; Belloy, M; Benkerrou, M; Ducrocq, R; Maier-Redelsperger, M; de Montalembert, M; Quinet, B; Elion, J; Feingold, J; Girot, R

    2000-09-01

    A subset of 299 patients with homozygous sickle cell anaemia, enrolled in the cohort of the French Study Group on sickle cell disease (SCD), was investigated in this study. The majority of patients were children (mean age 10.1 +/- 5.8 yr) of first generation immigrants from Western and Central Africa, the others originated from the French West Indies (20.2%). We report the frequency of the main clinical events (mean follow-up 4.2 +/- 2.2 yr). The prevalence of meningitis-septicaemia and osteomyelitis was, respectively, 11.4% and 12% acute chest syndrome was observed in 134 patients (44.8%). Twenty patients (6.7%) developed stroke with peak prevalence at 10-15 yr of age. One hundred and seventy-two patients (58%) suffered from one or more painful sickle cell crises, while the others (42.5%) never suffered from pain. The overall frequency of acute anaemic episodes was 50.5%, (acute aplastic anaemia 46%; acute splenic sequestration 26%). A group of 27 patients were asymptomatic (follow-up > 3 yr). Epistatic mechanisms influencing SCD were studied. Coinherited alpha-thalassemia strongly reduced the risk of stroke (p <0.001) and increased that of painful crises (p < 0.02). There was a low prevalence of Senegal and Bantu (CAR) betas-chromosomes in patients with meningitis (p <0.04) and osteomyelitis (p < 0.03). Prevalence of Senegal betas-chromosomes was lower in the asymptomatic group of 27 patients (p < 0.02). The patients come from a population of unmixed immigrants in whom the beta-globin gene haplotype strongly reflects the geographic origin and identifies subgroups with a homogenous genetic background. Thus the observed effects might result more from differences in as yet unidentified determinants in the genetic background than from the direct linkage with differences in the beta-globin gene locus.

  20. Genetic hemochromatosis is a rare disease entity among French Basques: a center-based study from the general hospital of Basque County.

    PubMed

    Bauduer, F; Scribans, C; Renoux, M; Borot, N

    2001-08-01

    A center-based study from the general hospital of Basque country has been performed to evaluate the importance of genetic hemochromatosis among French Basques. A sample of 37 patients from 34 families fulfilling the diagnosis criteria of hemochromatosis was obtained. Only four of them were of Basque origin: two homozygotes for C282Y, one homozygote for H63D, and one heterozygote for C282Y. These results suggest a significant lower prevalence of genetic hemochromatosis in Basques than in people from other French regions (P=0.001). They underline further the biological specificity of this population.

  1. The argumentative connective même in French: an experimental study in eight- to ten-year-old children.

    PubMed

    Bassano, D; Champaud, C

    1989-10-01

    This study examines how children understand the argumentative function of the French connective même ('even'). Two completion tasks, related to the argumentative properties of the morpheme, were used: (1) to infer the conclusion of an 'even' sentence, and (2) to infer the argument position. Two main factors likely to influence the comprehension were investigated: the semantic context, and the syntactic form--affirmative vs negative. The argumentative function of même was globally mastered at the age of eight, but comprehension depends on semantic context. Performances were better for negative sentences, which suggests that negation plays a facilitating role; the specific properties of the negative expression pas même/même pas ('not even') in discourse are discussed.

  2. Divergences on the environmental impact associated to the production of maritime pine wood in Europe: French and Portuguese case studies.

    PubMed

    González-García, Sara; Dias, Ana Cláudia; Feijoo, Gumersindo; Moreira, María Teresa; Arroja, Luis

    2014-02-15

    Life Cycle Assessment (LCA) has become a common methodology to evaluate the environmental performance of forest systems in recent years. This study aims to estimate the environmental profile associated with maritime pine wood production in two representative European countries: Portugal and France. Different forest management regimes based on low and high intensive conditions were evaluated and differences in logging equipment, biomass yield and lifespan were also reported. The study was completed with a sensitivity analysis based on two allocation approaches (economic and volumetric) since biomass from thinning processes is harvested and can be used as a co-product. The production of maritime pine in Portugal under low intensity conditions should present the best environmental results with reductions of 50-94% in comparison with the worst scenario. It is mainly associated with the absence of forest activities in periods previous to the logging stage. French intensive forest scenario ranks as the second best alternative of pine wood production. The remaining scenarios reported worse results in terms of environmental impacts mostly due to the remarkable repetition of a selection of those forest activities with large fuel requirement (mainly on site preparation and stand establishment and tending). Regardless of the scenario, logging related activities such as final cutting and forwarding were identified as the hotspots mainly due to the fuel requirements. Fertilizer production (if required), thinning and cleaning processes reported also remarkable contributions to the categories under assessment. In addition, an economic estimation for each forest management scenario has been performed mainly considering fuel, machinery and labor costs. According to the results, the Portuguese low intensive scenario is the best choice together with the French intensive scenario under an economic point of view because of the lowest production costs per functional unit. Activities

  3. Towards a French Revolution

    ERIC Educational Resources Information Center

    Breach, H. T.

    1972-01-01

    Contends that secondary school students lose their appeal for French as they advance in school. Suggests that French teachers endeavor to motivate students by focusing more attention on their students and less on their own credentials. (DS)

  4. Early Diagenetic Imprint on Temperature Proxies in Holocene Corals: A Case Study from French Polynesia

    NASA Astrophysics Data System (ADS)

    Rashid, R. J.; Eisenhauer, A.; Liebetrau, V.; Fietzke, J.; Boehm, F.; Wall, M.; Krause, S.; Rueggeberg, A.; Dullo, C.; Samankassou, E.

    2014-12-01

    Coral based reconstructions of sea surface temperatures (SST) using Sr/Ca, U/Ca and δ18O ratios are an important tool for quantitative reconstructions of past climate. However, post-depositional alteration of coral aragonite due to early diagenesis is restricting the accuracy of calibrated proxies even on relatively young corals. Here we present Mid to Late Holocene SST reconstructions using well dated (U/Th: ~70yr to 5.4ka) fossil Porites collected from the Society Islands, French Polynesia. Microscopic observations and microprobe mapping show the presence of aragonite needles inside the coral pores. They are characterized by high Sr/Ca ratios of up to 14.7±0.3mmol/mol, shifting the corresponding SST to ~6.2±1.1°C. Inhomogeneous distribution of Sr/Ca reflects partial dissolution, pore fluid percolation and re-precipitation of Sr within the coral. The resulting effect of early diagenesis on the SST records is reflected by significant temperature offsets up to ±6°C. A relative SST reconstruction is still feasible by normalizing the records to their individual mean value. Latter approach shows that all three records are in phase with simultaneous SST variability of up to ±2.4°C with respect to the Holocene mean value. Low SSTs are observed between ~4.4 to ~4.9ka BP and ~2.8 to ~3.4ka BP. Relatively high temperatures are observed at ~5ka BP, between ~3.7 and 3.9ka BP as well as at ~1.8ka BP to ~2.6ka BP. This indicates SST oscillations with the periodicity of 1500yrs in the Society island record which is in general accord with the solar activity reconstructed from 10Be and 14C production (Vonmoos et al., 2006, JGR 111, A10105). In particular, the relatively high SST reconcile empirically determined sea level variations (Rashid et al., 2014, G3, 15) indicating a higher sea level than predicted from numerical modelling taking only "Glacial Isostatic Adjustment" into account as the primary controlling factor for the Late Holocene sea level variation.

  5. French Computer Terminology.

    ERIC Educational Resources Information Center

    Gray, Eugene F.

    1985-01-01

    Characteristics, idiosyncrasies, borrowings, and other aspects of the French terminology for computers and computer-related matters are discussed and placed in the context of French computer use. A glossary provides French equivalent terms or translations of English computer terminology. (MSE)

  6. Longitudinal study of associations between perceived health status and self reported diseases in the French Gazel cohort

    PubMed Central

    Goldberg, P; Gueguen, A; Schmaus, A; Nakache, J; Goldberg, M

    2001-01-01

    STUDY OBJECTIVE—Although perceived health status is an indicator widely used in epidemiological studies, its relation to various diseases is not well known. The objective of this study is to examine these relations in detail.
DESIGN—Marginal models used for a longitudinal study of the association between three health scales and 47 diseases among 12 164 men and 44 diseases among 4415 women.
SETTING—French Gazel cohort during the period from 1991 to 1996.
MAIN RESULTS—The general health status scale was significantly associated with 43 diseases among men, and 31 among women. Some of these significantly associated diseases were physical (for example, cancer and cerebrovascular accident) and others, psychological (for example, depression). The mental fatigue scale was more specifically associated with psychological disorders, including sleep problems, depression, and nervous diseases. Moreover, modifications in subjects' assessment of their health from one year to the next were generally associated with modifications in reported diseases.
CONCLUSION—Although the mechanism that relates the presence of a disease to perceived health status remains in question, these results show clearly that there is a close association between these two domains that justifies the use of perceived health as a proxy for self reported diseases.


Keywords: marginal model; health scale; self rated disease PMID:11238577

  7. Acoustic-phonetics of coronal stops: A cross-language study of Canadian English and Canadian French

    NASA Astrophysics Data System (ADS)

    Sundara, Megha

    2005-08-01

    The study was conducted to provide an acoustic description of coronal stops in Canadian English (CE) and Canadian French (CF). CE and CF stops differ in VOT and place of articulation. CE has a two-way voicing distinction (in syllable initial position) between simultaneous and aspirated release; coronal stops are articulated at alveolar place. CF, on the other hand, has a two-way voicing distinction between prevoiced and simultaneous release; coronal stops are articulated at dental place. Acoustic analyses of stop consonants produced by monolingual speakers of CE and of CF, for both VOT and alveolar/dental place of articulation, are reported. Results from the analysis of VOT replicate and confirm differences in phonetic implementation of VOT across the two languages. Analysis of coronal stops with respect to place differences indicates systematic differences across the two languages in relative burst intensity and measures of burst spectral shape, specifically mean frequency, standard deviation, and kurtosis. The majority of CE and CF talkers reliably and consistently produced tokens differing in the SD of burst frequency, a measure of the diffuseness of the burst. Results from the study are interpreted in the context of acoustic and articulatory data on coronal stops from several other languages.

  8. Acoustic-phonetics of coronal stops: a cross-language study of Canadian English and Canadian French.

    PubMed

    Sundara, Megha

    2005-08-01

    The study was conducted to provide an acoustic description of coronal stops in Canadian English (CE) and Canadian French (CF). CE and CF stops differ in VOT and place of articulation. CE has a two-way voicing distinction (in syllable initial position) between simultaneous and aspirated release; coronal stops are articulated at alveolar place. CF, on the other hand, has a two-way voicing distinction between prevoiced and simultaneous release; coronal stops are articulated at dental place. Acoustic analyses of stop consonants produced by monolingual speakers of CE and of CF, for both VOT and alveolar/dental place of articulation, are reported. Results from the analysis of VOT replicate and confirm differences in phonetic implementation of VOT across the two languages. Analysis of coronal stops with respect to place differences indicates systematic differences across the two languages in relative burst intensity and measures of burst spectral shape, specifically mean frequency, standard deviation, and kurtosis. The majority of CE and CF talkers reliably and consistently produced tokens differing in the SD of burst frequency, a measure of the diffuseness of the burst. Results from the study are interpreted in the context of acoustic and articulatory data on coronal stops from several other languages.

  9. Study of Groundwater Circulation Using Stable Isotopes : the Example of the Punaruu Watershed (Tropical Oceanic Island of Tahiti, French Polynesia)

    NASA Astrophysics Data System (ADS)

    Sichoix, L.; Hildenbrand, A.; Marlin, C.; Gillot, P. Y.; Pheulpin, L.; Barriot, J. P.

    2015-12-01

    The increasing demand for drinking and industrial water, especially in the most populated areas of the tropical oceanic Island of Tahiti in French Polynesia (South central Pacific), makes it necessary to conduct hydrological and hydrogeological studies on water resources and management. Our investigation area represents the second largest watershed of Tahiti called Punaruu. The largest industrial zone of Tahiti occupies the minor low valley of this catchment and is particularly impacted by dredging of the stream and rock removals since several decades whereas the major high part is naturally well preserved. This study aims to identify the main infiltration areas of the aquifers of this industrial zone as well as the areas at low elevations to be protected from potential pollutions. During the period between May 2013 and July 2015, we have collected rainwater samples from five rain gauges located at elevations ranging from 0 to 1420 m. We have also performed water sampling from the main rivers and three springs up to altitudes of 800 m as well as six pumping boreholes in the industrial zone. Chemical (major elements) and stable isotopic (δ18O and δ2H) analyses have been done from all these water samples and help us to constrain a conceptual model of groundwater circulation within such a complex discontinuous volcanic structure.

  10. Three Approaches to Teaching French: Evaluation and Overview of Studies Related to the Federally-Funded Extensions of the Second Language Learning (French) Programs in the Carleton and Ottawa School Boards.

    ERIC Educational Resources Information Center

    Stern, H. H.; And Others

    In 1973-75, as a result of federal grants, the four major boards of education in Ontario experimented with different approaches to the teaching of French, and an evaluation of the experimental programs was also undertaken. The present report is an overview and evaluation of the entire research effort. Three approaches to French instruction have…

  11. Reading Speed of Contracted French Braille

    ERIC Educational Resources Information Center

    Laroche, Louise; Boule, Jacinthe; Wittich, Walter

    2012-01-01

    This study was designed to address three hypotheses: (1) The reading speed of both readers of French braille and readers of French print will be faster in the silent condition; however, this gain in speed will be larger for print readers; (2) Individuals who acquired braille before age 10 will display faster reading speeds at lower error rates…

  12. Left Dislocation in Near-Native French

    ERIC Educational Resources Information Center

    Donaldson, Bryan

    2011-01-01

    The present study is concerned with the upper limits of SLA--specifically, mastery of the syntax-discourse interface in successful endstate learners of second-language (L2) French (near-native speakers). Left dislocation (LD) is a syntactic means of structuring spoken French discourse by marking topic. Its use requires speakers to coordinate…

  13. Neural correlates of the perception of contrastive prosodic focus in French: a functional magnetic resonance imaging study.

    PubMed

    Perrone-Bertolotti, Marcela; Dohen, Marion; Lœvenbruck, Hélène; Sato, Marc; Pichat, Cédric; Baciu, Monica

    2013-10-01

    This functional magnetic resonance imaging (fMRI) study aimed at examining the cerebral regions involved in the auditory perception of prosodic focus using a natural focus detection task. Two conditions testing the processing of simple utterances in French were explored, narrow-focused versus broad-focused. Participants performed a correction detection task. The utterances in both conditions had exactly the same segmental, lexical, and syntactic contents, and only differed in their prosodic realization. The comparison between the two conditions therefore allowed us to examine processes strictly associated with prosodic focus processing. To assess the specific effect of pitch on hemispheric specialization, a parametric analysis was conducted using a parameter reflecting pitch variations specifically related to focus. The comparison between the two conditions reveals that brain regions recruited during the detection of contrastive prosodic focus can be described as a right-hemisphere dominant dual network consisting of (a) ventral regions which include the right posterosuperior temporal and bilateral middle temporal gyri and (b) dorsal regions including the bilateral inferior frontal, inferior parietal and left superior parietal gyri. Our results argue for a dual stream model of focus perception compatible with the asymmetric sampling in time hypothesis. They suggest that the detection of prosodic focus involves an interplay between the right and left hemispheres, in which the computation of slowly changing prosodic cues in the right hemisphere dynamically feeds an internal model concurrently used by the left hemisphere, which carries out computations over shorter temporal windows.

  14. FEMIC (Fibromes Embolises aux MICrospheres calibrees): Uterine Fibroid Embolization using Tris-acryl Microspheres. A French Multicenter Study

    SciTech Connect

    Joffre, Francis; Tubiana, Jean-Michel; Pelage, Jean-Pierre

    2004-11-15

    Purpose: A French multicenter registry was set up to confirm the safety and efficacy of large calibrated tris-acryl gelatin microspheres for embolization of symptomatic fibroids. Methods: Technical recommendations included embolization using large microspheres (>500 {mu}m) with no secondary embolization agent. Postprocedural pain, clinical improvement and adverse events were prospectively evaluated during a follow-up period of at least 6 months.Results: Eighty-five women complaining of fibroid-related symptoms entered the study. In seven women, a secondary embolization agent was used in addition to microspheres. Complete resolution of menorrhagia was achieved in 84% of women at 24 months and significant uterine and fibroid volume reductions were noted after 6 months (37% and 73%, respectively). Three women experienced definitive amenorrhea (4%) and two women required hysteroscopic resection of a fibroid. Eight women were treated by hysterectomy because of treatment failure. In seven of these women, treatment failure was explained by an additional cause of symptoms including diffuse adenomyosis, endometrial hyperplasia or ovarian artery supply to the fibroids.Conclusion: Limited uterine artery embolization using large microspheres has good clinical success rate with low postprocedural pain and complications. Women can expect excellent midterm results with a high level of symptom control and significant fibroid volume reduction. Confidence in the end-point recommended here may require the experience of several cases.

  15. Experimental study of rock erodibility - diagenetic grade relationship, application to the Annot sandstone, French-Italian Alps

    NASA Astrophysics Data System (ADS)

    Steer, P.; Cattin, R.; Gibert, B.; Labaume, P.; Loggia, D.; Soliva, R.; Taboada, A.; Jolivet, M.; Lavé, J.; Sizun, J.

    2009-12-01

    In the large scale studies of landscape evolution, rock erodibility is a key parameter which controls the capacity of a rock to be eroded under the action of erosive agents. This parameter is primary controlled by lithology. However it also integrates both microscopic and macroscopic parameters, as grain cohesion or fracture density. Despite its extensive use in erosion law for field or numerical studies, quantifying river bedrock erodibility is still an ongoing issue. Previous studies have highlighted the first order control of rock nature on bedrock erodibility. Here we rather investigate the effect of diagenetic grade using both laboratory measurements and erodibility data collected on the field with a Schmidt hammer. We consider Scmidt hammer measurements as a proxy for erodibility. Our approach is applied to the well-studied Annot sandstones localized in the southern part of the external French-Italian Alps. Due to thrust front propagation in the external Alpine domain, this Upper Eocene-Lower Oligocene foreland basin formation has been partly buried below allochthonous units during the Oligocene. Exhumed by thrusting during the late Miocene, this formation now exhibits a clear diagenetic gradient increasing from west to east. Taking advantage of availability of a wide petrographic and petrophysical data set, we study the spatial variation of the Annot sandstone erodibility to the estimated diagenetic grade. Our preliminary results reveal that erodibility is closely correlated to the diagenetic grade, with the external (western) part of the Annot sandstones exhibiting higher erodibility than the internal (eastern) part. At the scale of the outcrop, erodibility is characterized by a high variability which statistically does not correlate with density, elastic parameters, porosity or minerals content. We rather suggest that for equivalent diagenetic grade, erodibility is controlled by the density of fracturation.

  16. The Effects of Inventory on Vowel Perception in French and Spanish: An MEG Study

    ERIC Educational Resources Information Center

    Hacquard, Valentine; Walter, Mary Ann; Marantz, Alec

    2007-01-01

    Production studies have shown that speakers of languages with larger phoneme inventories expand their acoustic space relative to languages with smaller inventories [Bradlow, A. (1995). A comparative acoustic study of English and Spanish vowels. "Journal of the Acoustical Society of America," 97(3), 1916-1924; Jongman, A., Fourakis, M., & Sereno,…

  17. Teaching French to Franco-Americans: A Controversial Problem.

    ERIC Educational Resources Information Center

    Hickel, Raymond A.

    1965-01-01

    A study of bilingualism among third-generation Americans of French-Canadian extraction briefly examines their linguistic superiority in French over monolingual students and appraises the appropriate psychological approaches to teaching this special group. The article suggests that an "educated standard French" be presented as an alternative to…

  18. Negation in Near-Native French: Variation and Sociolinguistic Competence

    ERIC Educational Resources Information Center

    Donaldson, Bryan

    2017-01-01

    This study investigated how adult second language (L2) speakers of French with near-native proficiency realize verbal negation, a well-known sociolinguistic variable in contemporary spoken French. Data included 10 spontaneous informal conversations between near-native speakers of French and native speakers (NSs) closely acquainted with them.…

  19. The activity of French Research Ethics Committees and characteristics of biomedical research protocols involving humans: a retrospective cohort study

    PubMed Central

    Decullier, Evelyne; Lhéritier, Véronique; Chapuis, François

    2005-01-01

    Background Clinical trials throughout the world must be evaluated by research ethics committees. No one has yet attempted to clearly quantify at the national level the activity of ethics committees and describe the characteristics of the protocols submitted. The objectives of this study were to describe 1) the workload and the activity of Research Ethics Committees in France, and 2) the characteristics of protocols approved on a nation-wide basis. Methods Retrospective cohort of 976 protocols approved by a representative sample of 25/48 of French Research Ethics Committees in 1994. Protocols characteristics (design, study size, investigator), number of revisions requested by the ethics committee before approval, time to approval and number of amendments after approval were collected for each protocol by trained research assistant using the committee's files and archives. Results Thirty-one percent of protocols were approved with no modifications requested in 16 days (95% CI: 14–17). The number of revisions requested by the committee, and amendments submitted by the investigator was on average respectively 39 (95% CI: 25–53) and 37 (95% CI: 27–46), per committee and per year. When revisions were requested, the main reasons were related to information to the patient (28%) and consent modalities (18%). Drugs were the object of research in 68% of the protocols examined. The majority of the research was national (80%) with a predominance of single-centre studies. Workload per protocol has been estimated at twelve and half hours on average for administrative support and at eleven and half hours for expertise. Conclusion The estimated workload justifies specific and independent administrative and financial support for Research Ethics Committees. PMID:16229743

  20. Reevaluating the French Revolution.

    ERIC Educational Resources Information Center

    Stromberg, Roland N.

    1986-01-01

    Analyzes previous interpretations concerning the French Revolution. Discusses several weaknesses of the Marxist views in light of recent philosophical and sociological thinking about social change. (RKM)

  1. [Thyroid hormone levels and thyroid dysfunction of French adults participating in the SU.VI.MAX study].

    PubMed

    Valeix, P; Dos Santos, C; Castetbon, K; Bertrais, S; Cousty, C; Hercberg, S

    2004-12-01

    Abnormal thyroid function has important public health consequences. However, the various degrees of thyroid dysfunction remain unsettled. The SU.VI.MAX cohort provided a unique opportunity to conduct a cross-sectional study of abnormal thyroid function in a large representative population of 11256 men and women representing the geographic distribution of the French continental adult population. Thyroid status was measured, in fasting blood samples, at baseline in 1994-1995. Serum thyrotropin (TSH) levels (abnormal < 0.4 mU/l or > or =4.0 mU/l) and free thyroxine (fT4) were both performed in duplicate on the same sample. Subjects with previous or present thyroid diseases or who were taking thyroid hormones or antithyroid drugs (n=920) were excluded (8.1%). Thus, the final study group consisted of 10346 subjects, 4121 men aged 45-60 years (mean +/-SD) (51.8+/-4.7 yrs), 2641 women aged 35-44 years (40.6+/-2.8 yrs), and 3584 women aged 45-60 years (51.4+/-4.4 yrs). Median (2.5th and 97.5th percentiles) for TSH (mU/l) were 1.52 (0.20-4.54) for men, 1.78 (0.22-5.54) for women aged 35-44 years, and 1.96 (0.22-6.80) for women aged 45-60 years. The TSH distribution of women was shifted to the right compared with men. Arithmetic mean fT4 (+/-SD) was 10.7+/-1.7 ng/l (13.8 +/-2.2 pmol/l) for men and 10.9+/-1.8 ng/l (14.0+/-2.3 pmol/l) for women. The prevalence of abnormal TSH values in men, and in women (35-44 yrs and 45-60 yrs) were TSH<0.4 mU/l 7.0%, 5.3% and 4.4%; TSH 4.0-9.9 mU/l 4.0%, 7.2% and 11.1% and TSH > or =10.0 mU/l 0.2%, 0.4% and 0.7%, respectively. Geometric mean serum TSH and arithmetic mean serum fT4 concentrations showed significant overall inter-regional differences for men and women (p<0.0001). There was also an inter-regional difference in the prevalence of thyroid dysfunction for men (p=0.003), and for the older group of women (i.e. > or =45 yrs) (p=0.04) exclusively. Over the age of 45 years, the women: men ratio for unrecognized elevated TSH levels (> or

  2. French String Grammar. Final Report.

    ERIC Educational Resources Information Center

    New York Univ., NY. Linguistic String Project.

    This work reports on an initial study of the possibility of providing a suitable framework for the teaching of a foreign language grammar through string analysis, using French as the target language. Analysis of a string word list (word-class sequences) yields an overall view of the grammar. Details are furnished in a set of restrictions which…

  3. The Role of Form and Meaning in the Processing of Written Morphology: A Priming Study in French Developing Readers

    ERIC Educational Resources Information Center

    Quemart, Pauline; Casalis, Severine; Cole, Pascale

    2011-01-01

    Three visual priming experiments using three different prime durations (60 ms in Experiment 1, 250 ms in Experiment 2, and 800 ms in Experiment 3) were conducted to examine which properties of morphemes (form and/or meaning) drive developing readers' processing of written morphology. French third, fifth, and seventh graders and adults (the latter…

  4. Inductive/Deductive Learning by Considering the Role of Gender--A Case Study of Iranian French-Learners

    ERIC Educational Resources Information Center

    Rahmatian, Rouhollah; Zarekar, Fatemeh

    2016-01-01

    This article defines the objective of discovering the first preferred styles of Iranian learners of French as a Foreign Language (FFL) as regards inductive or deductive learning; and secondly, the difference between gender-based learning tendencies. Considering these points as target variables, the questionnaire developed by Felder and Silverman…

  5. Scientific Productivity and Academic Promotion: A Study on French and Italian Physicists. NBER Working Paper No. 16341

    ERIC Educational Resources Information Center

    Lissoni, Francesco; Mairesse, Jacques; Montobbio, Fabio; Pezzoni, Michele

    2010-01-01

    The paper examines the determinants of scientific productivity (number of articles and journals' impact factor) for a panel of about 3600 French and Italian academic physicists active in 2004-05. Endogeneity problems concerning promotion and productivity are addressed by specifying a generalized Tobit model, in which a selection probit equation…

  6. Concurrent Models and Cross-Linguistic Analogies in the Study of Prepositional Stranding in French in Canada

    ERIC Educational Resources Information Center

    Otheguy, Ricardo

    2012-01-01

    Prepositions can be found with and without adjacent complements in many forms of popular spoken French. The alternation appears in main clauses ("il veut pas payer pour ca [approximately] il veut pas payer pour" "he doesn't want to pay for [it]") and, though with a more restricted social and geographic distribution, in relative…

  7. Hemispheric Asymmetries Depend on the Phonetic Feature: A Dichotic Study of Place of Articulation and Voicing in French Stops

    ERIC Educational Resources Information Center

    Bedoin, Nathalie; Ferragne, Emmanuel; Marsico, Egidio

    2010-01-01

    Dichotic listening experiments show a right-ear advantage (REA), reflecting a left-hemisphere (LH) dominance. However, we found a decrease in REA when the initial stop consonants of two simultaneous French CVC words differed in voicing rather than place of articulation (Experiment 1). This result suggests that the right hemisphere (RH) is more…

  8. The Argumentative Connective "Meme" in French: An Experimental Study in Eight- to Ten-Year-Old Children.

    ERIC Educational Resources Information Center

    Bassano, Dominique; Champaud, Christian

    1989-01-01

    Examines how children understand the argumentative function of the French connective meme (even). Two completion tasks, related to the argumentative properties of the morpheme, were used: 1) to infer the conclusion of an "even" sentence, and 2) to infer the argument position. (34 references) (Author/CB)

  9. Comorbidities against Quality Control of VKA Therapy in Non-Valvular Atrial Fibrillation: A French National Cross-Sectional Study

    PubMed Central

    Rouaud, Agnes; Hanon, Olivier; Boureau, Anne-Sophie; Chapelet, Guillaume Gilles; de Decker, Laure

    2015-01-01

    Background Given the prevalence of non-valvular atrial fibrillation in the geriatric population, thromboembolic prevention by means of vitamin K antagonists (VKA) is one of the most frequent daily concerns of practitioners. The effectiveness and safety of treatment with VKA correlates directly with maximizing the time in therapeutic range, with an International Normalized Ratio (INR) of 2.0-3.0. The older population concentrates many of factors known to influence INR rate, particularly concomitant medications and concurrent medical conditions, also defined as comorbidities. Objective Determine whether a high burden on comorbidities, defined by a Charlson Comorbidity Index (CCI) of 3 or greater, is associated a lower quality of INR control. Study-Design Cross-sectional study. Settings French geriatric care units nationwide. Participants 2164 patients aged 80 and over and treated with vitamin K antagonists. Measurements Comorbidities were assessed using the Charlson Comorbidity Index (CCI). The recorded data included age, sex, falls, kidney failure, hemorrhagic event, VKA treatment duration, and the number and type of concomitant medications. Quality of INR control, defined as time in therapeutic range (TTR), was assessed using the Rosendaal method. Results 487 patients were identified the low-quality control of INR group. On multivariate logistic regression analysis, low-quality control of INR was independently associated with a CCI ≥3 (OR = 1.487; 95% CI [1.15; 1.91]). The other variables associated with low-quality control of INR were: hemorrhagic event (OR = 3.151; 95% CI [1.64; 6.07]), hospitalization (OR = 1.614, 95% CI [1.21; 2.14]). Conclusion An elevated CCI score (≥3) was associated with low-quality control of INR in elderly patients treated with VKA. Further research is needed to corroborate this finding. PMID:25789771

  10. Observational Study of a French and Belgian Multicenter Cohort of 23 Patients Diagnosed in Adulthood With Mevalonate Kinase Deficiency

    PubMed Central

    Durel, Cécile-Audrey; Aouba, Achille; Bienvenu, Boris; Deshayes, Samuel; Coppéré, Brigitte; Gombert, Bruno; Acquaviva-Bourdain, Cécile; Hachulla, Eric; Lecomte, Frédéric; Touitou, Isabelle; Ninet, Jacques; Philit, Jean-Baptiste; Messer, Laurent; Brouillard, Marc; Girard-Madoux, Marie-Hélène; Moutschen, Michel; Raison-Peyron, Nadia; Hutin, Pascal; Duffau, Pierre; Trolliet, Pierre; Hatron, Pierre-Yves; Heudier, Philippe; Cevallos, Ramiro; Lequerré, Thierry; Brousse, Valentine; Lesire, Vincent; Audia, Sylvain; Maucort-Boulch, Delphine; Cuisset, Laurence; Hot, Arnaud

    2016-01-01

    Abstract The aim of this study was to describe the clinical and biological features of Mevalonate kinase deficiency (MKD) in patients diagnosed in adulthood. This is a French and Belgian observational retrospective study from 2000 to 2014. To constitute the cohort, we cross-check the genetic and biochemical databases. The clinical, enzymatic, and genetic data were gathered from medical records. Twenty-three patients were analyzed. The mean age at diagnosis was 40 years, with a mean age at onset of symptoms of 3 years. All symptomatic patients had fever. Febrile attacks were mostly associated with arthralgia (90.9%); lymphadenopathy, abdominal pain, and skin lesions (86.4%); pharyngitis (63.6%); cough (59.1%); diarrhea, and hepatosplenomegaly (50.0%). Seven patients had psychiatric symptoms (31.8%). One patient developed recurrent seizures. Three patients experienced renal involvement (13.6%). Two patients had angiomyolipoma (9.1%). All but one tested patients had elevated serum immunoglobulin (Ig) D level. Twenty-one patients had genetic diagnosis; most of them were compound heterozygote (76.2%). p.Val377Ile was the most prevalent mutation. Structural articular damages and systemic AA amyloidosis were the 2 most serious complications. More than 65% of patients displayed decrease in severity and frequency of attacks with increasing age, but only 35% achieved remission. MKD diagnosed in adulthood shared clinical and genetic features with classical pediatric disease. An elevated IgD concentration is a good marker for MKD in adults. Despite a decrease of severity and frequency of attacks with age, only one-third of patients achieved spontaneous remission. PMID:26986117

  11. Assessment of schoolchildren's exposure to traffic-related air pollution in the French Six Cities Study using a dispersion model

    NASA Astrophysics Data System (ADS)

    Pénard-Morand, Céline; Schillinger, Charles; Armengaud, Alexandre; Debotte, Ginette; Chrétien, Eve; Pellier, Serge; Annesi-Maesano, Isabella

    The purpose of this work was to estimate exposure to traffic-related air pollution (TAP), of the 6683 schoolchildren included in a cross-sectional epidemiological study conducted in six French cities to determine the effects of urban air pollution (AP) on respiratory and allergic health. Annual mean concentrations of benzene, CO, NO 2, NO x, PM 10 and SO 2 were calculated, in front of the 108 schools attended by the children, by the validated STREET 5 software, which combines data on regional and local components of AP. STREET contains a database of emissions estimated by the IMPACT 2.0 software developed by ADEME-France and results of ambient concentrations modelled by the WinMISKAM 4.2 dispersion model. The input data required were background AP, traffic conditions (daily traffic density; average speed; percentage of gridlocks and proportion of each type of vehicle) and dispersion conditions (topography of the street segments modelled and meteorology). Emissions of air pollutants in front of the 108 schools were considerably scattered. Calculated concentrations (μg m -3) also varied considerably at: [1.0-5.1] for benzene, [303.8-988.1] for CO, [17.8-78.9] for NO 2, [23.3-195.2] for NO x, [10.0-52.0] for PM 10 and [2.4-16.4] for SO 2. About 64% (29%, respectively) of the schools had annual mean concentrations of NO 2 (PM 10, respectively) exceeding the European quality objectives (40 and 30 μg m -3, respectively). These exposure indicators, capable of identifying small area variations in AP contrary to surrogate measures usually used in epidemiology, will enable better studies on the impact of urban AP on health.

  12. Feasibility and performance study for a space-borne 1645 nm OPO for French-German satellite mission MERLIN

    NASA Astrophysics Data System (ADS)

    Elsen, Florian; Heinzig, Matthias; Livrozet, Marie J.; Löhring, Jens; Wüppen, Jochen; Büdenbender, Christian; Fix, Andreas; Jungbluth, Bernd; Hoffmann, Hans-Dieter

    2014-05-01

    We present a theoretical and experimental analysis of a pulsed 1645 nm optical parametric oscillator (OPO) to prove the feasibility of such a device for a spaceborne laser transmitter in an integrated path differential absorption (IPDA) lidar system. The investigation is part of the French-German satellite mission MERLIN (Methane Remote Sensing Lidar Mission). As an effective greenhouse gas, methane plays an important role for the global climate. The architecture of the OPO is based on a conceptual design developed by DLR, consisting of two KTA crystals in a four-mirror-cavity. Using numerical simulations, we studied the performance of such a setup with KTP and investigated means to optimize the optical design by increasing the efficiency of the OPO and decreasing the fluence on the optical components. For the experimental testing of the OPO, we used the INNOSlab-based ESA pre-development model ATLAS as pump laser at 1064 nm. The OPO obtained 9.2 mJ pulse energy at 1645 nm from 31.5 mJ of the pump and a pump pulse duration of 42 ns. This corresponds to an optical/optical efficiency of 29%. After the pump pulse was reduced to 24 ns, a similar OPO performance could be obtained by adapting the pump beam radius. In recent experiments with optimized optical design the OPO obtained 12.5 mJ pulse energy at 1645 nm from 32.0 mJ of the pump, corresponding to an optical/optical efficiency of 39%. Two different methods were applied to study the laser damage thresholds of the optical elements used.

  13. Long-term effectiveness and safety of interleukin-1 receptor antagonist (anakinra) in Schnitzler's syndrome: a French multicenter study.

    PubMed

    Néel, Antoine; Henry, Benoit; Barbarot, Sebastien; Masseau, Agathe; Perrin, François; Bernier, Claire; Kyndt, Xavier; Puechal, Xavier; Weiller, Pierre-Jean; Decaux, Olivier; Ninet, Jacques; Hot, Arnaud; Aouba, Achille; Astudillo, Leonardo; Berthelot, Jean-Marie; Bonnet, Fabrice; Brisseau, Jean-Marie; Cador, Bérangère; Closs-Prophette, Fabienne; Dejoie, Thomas; de Korwin, Jean-Dominique; Dhote, Robin; Fior, Renato; Grosbois, Bernard; Hachulla, Eric; Hatron, Pierre-Yves; Jardel, Henry; Launay, David; Lorleac'h, Adrien; Pottier, Pierre; Moulis, Guillaume; Serratrice, Jacques; Smail, Amar; Hamidou, Mohamed

    2014-10-01

    The aim of this study is to assess the long-term effectiveness and safety of IL1Ra in Schnitzler syndrome (SchS). Between 2010 and 2012, we performed a nationwide survey among French internal medicine departments to identify SchS patients. We retrospectively analyzed the long-term efficacy and safety of IL1Ra and the outcome of patients that did not receive this treatment. Forty-two patients were included in the study, 29 of whom received IL1Ra. The mean age at disease onset was 59.9years. Disease manifestations included urticaria (100%), fever (76%), bone/joint pain (86%), bone lesions (76%), anemia (67%), and weight loss (60%). The monoclonal gammopathy was overwhelmingly IgM kappa (83%). The mean follow-up was 9.5years (range: 1.6-35). Two patients developed Waldenström's macroglobulinemia and one developed AA amyloidosis. All of the 29 patients who received IL1Ra responded dramatically. After a median follow-up of 36months (range: 2-79), the effectiveness remained unchanged. All patients remained on anti-IL-1 therapy. Twenty-four patients (83%) went into complete remission and five (17%) into partial remission. Three patients experienced grade 3-4 neutropenia. Six patients developed severe infections. No lymphoproliferative diseases occurred while on IL1Ra. When last seen, all patients without anakinra had an active disease with variable impact on their quality of life. Their median corticosteroids dosage was 6mg/d (range: 5-25). IL1Ra is effective in SchS, with a sharp corticosteroid-sparing effect. Treatment failures should lead to reconsider the diagnosis. Long-term follow-up revealed no loss of effectiveness and a favorable tolerance profile. The long-term effects on the risk of hemopathy remain unknown.

  14. State of the art on forest and shallow landslide interactions illustrated by two studies in the French Alps

    NASA Astrophysics Data System (ADS)

    Berger, F.; Dorren, L.; Lopez, J.; Allegra, C.

    2009-04-01

    landslide prevention and mitigation and due to the lack of scientific knowledge on the interaction between forest stands and landslide activities, there is a real need of research axis specifically devoted to the tree main effects cited before. The main objective of these thematically research axis should be an efficient integration of the effect of the forest vegetation in the modelling of shallow landslide dynamic. This presentation deals with the state of the art on forest and landslide interaction illustrated by two studies conducted in the French Alps. The first one attempts to reduce a gap in the scientific knowledge by quantifying the hazard of landslide occurrence considering vegetation effects, in the Combeloup forest on the French Alps, using a physically based spatial modelling approach. The second one present the added value of dendrogeomorphological analyse to evaluate the past activities of landslide terrain in relationship with the evolution of the forest cover.

  15. Switches to English during French Service Encounters: Relationships with L2 French Speakers' Willingness to Communicate and Motivation

    ERIC Educational Resources Information Center

    McNaughton, Stephanie; McDonough, Kim

    2015-01-01

    This exploratory study investigated second language (L2) French speakers' service encounters in the multilingual setting of Montreal, specifically whether switches to English during French service encounters were related to L2 speakers' willingness to communicate or motivation. Over a two-week period, 17 French L2 speakers in Montreal submitted…

  16. Health Workforce Development: A Needs Assessment Study in French Speaking African Countries

    ERIC Educational Resources Information Center

    Chastonay, Philippe; Moretti, Roberto; Zesiger, Veronique; Cremaschini, Marco; Bailey, Rebecca; Pariyo, George; Kabengele, Emmanuel Mpinga

    2013-01-01

    In 2006, WHO alerted the world to a global health workforce crisis, demonstrated through critical shortages of health workers, primarily in Sub-Saharan Africa (WHO in World Health Report, 2006). The objective of our study was to assess, in a participative way, the educational needs for public health and health workforce development among potential…

  17. Early Perception of Written Syllables in French: An Event-Related Potential Study

    ERIC Educational Resources Information Center

    Doignon-Camus, Nadege; Bonnefond, Anne; Touzalin-Chretien, Pascale; Dufour, Andre

    2009-01-01

    The present study examined whether written syllable units are perceived in first steps of letter string processing. An illusory conjunction experiment was conducted while event-related potentials were recorded. Colored pseudowords were presented such that there was a match or mismatch between the syllable boundaries and the color boundaries. The…

  18. English-French Bilingual Education: The Elgin Study through Grade Five

    ERIC Educational Resources Information Center

    Barik, Henri C.; And Others

    1977-01-01

    Presents the results of the 1974-75 evaluation of the bilingual education program initiated in 1970 by the Elgin County Board of Education in St. Thomas, Ontario. The study covers grades 2 to 5 and is a follow-up to previous evaluations. (Author/CFM)

  19. Evaluating Evidence from a Historical Chemical Controversy: A Study in a French High School

    ERIC Educational Resources Information Center

    Archila, Pablo Antonio

    2015-01-01

    This paper addresses the importance of evaluating evidence for enriching critical thinking in the chemistry classroom. The purpose of the study was to examine the usefulness of a historical chemical controversy in promoting students' assessment of evidence. The investigation was conducted in a high school in Melun, France. 63 participants (24…

  20. Evolution of the prevalence of intestinal parasitic infections among the French armed forces in French Guiana.

    PubMed

    Christen, Jacques-Robert; Mura, Marie; Roudaut, Gwenaëlle; Drogoul, Anne-Sophie; Demar, Magalie; Briolant, Sébastien; Garnotel, Eric; Simon, Fabrice; Pommier De Santi, Vincent

    2016-07-01

    Two cross-sectional studies were performed 2 years apart in French military personnel deployed from France to French Guiana. In 2011, military medical centres in French Guiana reported 40 cases of intestinal parasitism in service members returning from illegal gold mining sites in the rainforest. In 2013, 48 out of 132 service members returning from French Guiana after a 4-month mission had eosinophilia and seven were infected with hookworm. A presumptive first-line treatment with albendazole could be the most pragmatic strategy.

  1. [Fibrinogen and pentoxifylline. Results of a French cooperative exploratory study of stage II arteritis].

    PubMed

    Soria, J; Lancrenon, S; Chassoux, G

    1989-01-01

    A collaborative exploratory study was undertaken by 139 private angiologists in 427 out-patients with PVD stage II treated for 90 days with Pentoxifylline 1 200 mg per day. In 306 patients (71,6%) the fibrinogen level was decreased by 0,21 g/l in mean (p less than 0.01). This significant decrease is correlated to the global improvement (p less than 0.01) and is within the magnitude of difference that is associated between vascular death and comparative groups in recent epidemiologic studies. In 121 patients (28, 4%) of the non responders in whom the claudication was not improved or was even worsened, no change in the fibrinogen level was seen.

  2. Qualitative approach to patient-reported outcomes in oncology: protocol of a French study

    PubMed Central

    Orri, Massimiliano; Sibeoni, Jordan; Labey, Mathilde; Bousquet, Guilhem; Verneuil, Laurence; Revah-Levy, Anne

    2015-01-01

    Introduction The past decade has been characterised by movement from a doctor-centred to a patient-centred approach to treatment outcomes, in which doctors try to see the illness through their patients’ eyes. Patients, family members and doctors are the three participants in cancer care, but their perspectives about what have been helpful during cancer treatment have never simultaneously and explicitly compared in the same qualitative study. The aim of this study project is to explore patients’ perspectives about the care they receive, as well as families’ and doctors’ perspectives about what have been helpful for the patient. These three points of view will be compared and contrasted in order to analyse the convergences and divergences in these perspectives. Methods and analysis This is a national multicentre qualitative study. Participants will be constituted by three different subsamples: (1) patients with cancer (skin, breast, urological and lung cancers), (2) their relatives, and (3) their referring physicians. Recruitment will follow the purposive sample technique, and the final sample size will be determined by data saturation. Data will be collected through open-ended semistructured interviews and independently analysed with NVivo V.10 software by three researchers according to the principles of Interpretative Phenomenological Analysis. Ethics and dissemination The research protocol received approval from the University Paris Descartes review board (IRB number: 20140600001072), and participants will provide written consent. To the best of our knowledge, this is the first study to focus on the simultaneous exploration of the separate points of view of patients, families and doctors about the care received during the cancer care journey. We expect that our findings will help to improve communication and relationships between doctors, patients and families. Comparison of these three points of view will provide information about the convergences and

  3. Video Games, Internet and Social Networks: A Study among French School students

    PubMed

    Dany, Lionel; Moreau, Laure; Guillet, Clémentine; Franchina, Carmelo

    2016-11-25

    Aim : Screen-based media use is gradually becoming a public health issue, especially among young people.Method : A local descriptive observational study was conducted in 11 colleges of the Bouches-du-Rhône department. All middle high school students were asked to fill in a questionnaire comprising questions about their demographic characteristics, their screen-based media use (Internet, video games, social networks), any problematic use (video games and social networks), self-esteem and quality of life.Results : A total of 950 college students (mean age : 12.96 years) participated in the research. The results show a high level and a very diverse screen-based media use. Boys more frequently played video games and girls go more frequently used social networks. The levels of problematic use were relatively low for all middle high school students. The level of problematic video game use was significantly higher in boys, and the level of problematic social network use was higher in girls.Conclusion : Differences in the use of video games or social networks raise the general issue of gender differences in society. This study indicates the need for more specific preventive interventions for screen-based media use. The addictive “nature” of certain practices needs to be studied in more detail.

  4. Hyperechogenic fetal bowel: a large French collaborative study of 682 cases.

    PubMed

    Simon-Bouy, B; Satre, V; Ferec, C; Malinge, M C; Girodon, E; Denamur, E; Leporrier, N; Lewin, P; Forestier, F; Muller, F

    2003-09-01

    Hyperechogenic fetal bowel is detected in 0.1-1.8% of pregnancies during the second or third trimester. This ultrasound sign is associated with cystic fibrosis or other conditions (e.g., chromosomal anomalies, viral infection) but no large-scale prospective studies have been conducted. This 1997-1998 multicenter study in 22 molecular biology laboratories identified 682 cases of hyperechogenic fetal bowel detected by routine ultrasound examination during the second (86%) or third trimester. The fetal bowel was considered hyperechogenic when its echogenicity was broadly similar to, or greater than, that of the surrounding bone. Karyotyping, screening for viral infection, and screening for cystic fibrosis mutations were performed in all cases. Pregnancy outcome and postnatal follow-up were obtained in 656 of the 682 cases (91%). In 447 cases (65.5%), a normal birth was observed. Multiple malformations were observed in 47 cases (6.9%), a significant chromosomal anomaly was noted in 24 (3.5%), cystic fibrosis in 20 (3%), and viral infection in 19 (2.8%). In utero unexplained fetal death occurred in 1.9% of cases, toxemia in 1.2%, IUGR in 4.1%, and premature birth in 6.2%. This study demonstrates that this ultrasound sign is potentially associated with medically significant outcomes. Having established that the bowel is hyperechogenic, recommended investigations should include a detailed scan with Doppler measurements, fetal karyotyping, cystic fibrosis screening, and infectious disease screening. After birth, newborns require pediatric examination because a surgical treatment may be necessary. This should be combined with clear counseling of the parents.

  5. Pesticide residues intake of French adults under increased consumption of fresh fruits and vegetables--a theoretical study.

    PubMed

    Barnat, Saida; Boisset, Michel; Casse, Francine; Catteau, Michel; Lecerf, Jean-Michel; Veschambre, Daniel; Periquet, Alain

    2010-02-01

    The increase of fresh vegetable and fruit (FVF) intake could contribute to the prevention of obesity and several major pathologies and thus represents a major public health goal in industrial countries. Nutritional recommendations for increased consumption of FVF could lead to ingestion of unwanted amounts of pesticides. This study was undertaken to evaluate theoretical exposure of French adults to pesticide residues under increasing amounts of FVF intake. Balanced menus with 200 - 400 - 600 - 800 and 1200 g FVF/day were established. Amounts of active substances brought by every FVF vector, at the maximum residue level (MRL) were summed up to determine the intake for each active substance. Values were compared to the Acceptable Daily Intake (ADI) to point out any potential over exposure. A maximalistic approach was adopted and no reducing factor due to processing was taken into account. It was found that under minimal recommended consumption of fruit and vegetables (400 g/d), no active substance reached the ADI, but 18 vs 144 were over 10% of the ADI. Raising FVF to 600 g/d increased the number of active substances over 10 % of the ADI to 24, but again in no case was the ADI exceeded. Doubling the intake to 800 g/d gives values over the ADI for 2 active substances only (cyhexatin and thirame). It was concluded that the increase in fruit and vegetables up to 800 g per day should not expose adults over the ADIs for a majority of authorized pesticides. In this regard, residues levels of ten active substances in fruit and vegetables should deserve particular attention.

  6. Drug safety of rosiglitazone and pioglitazone in France: a study using the French PharmacoVigilance database

    PubMed Central

    2011-01-01

    Background Thiazolidinediones (TZDs), rosiglitazone (RGZ) and pioglitazone (PGZ) are widely used as hypoglycemic drugs in patients with type 2 diabetes mellitus. The aim of our study was to investigate the profile of adverse drug reactions (ADRs) related to TZDs and to investigate potential risk factors of these ADRs. Methods Type 2 diabetic patients were identified from the French Database of PharmacoVigilance (FPVD) between 2002 and 2006. We investigated ADR related to TZD, focusing on 4 ADR: edema, heart failure, myocardial infarction and hepatitis corresponding to specific WHO-ART terms. Results Among a total of 99,284 adult patients in the FPVD, 2295 reports concerned type 2 diabetic patients (2.3% of the whole database), with 161 (7%) exposed to TZDs. The frequency of edema and cardiac failure was significantly higher with TZDs than in other patients (18% and 7.4% versus 0.8% and 0.1% respectively, p < 0.001) whereas the frequency of hepatitis was similar (5.9% versus 4%, NS). A multiple logistic regression model taking into account potential confounding factors (age, gender, drug exposure and co-morbidities) found that TZD exposure remained associated with heart failure and edema, but not with hepatitis or myocardial infarction. Conclusions Thiazolidinediones exposure is associated with an increased risk of edema and heart failure in patients with type 2 diabetes even when recommendations for use are respected. In contrast, the risk of hepatic reactions and myocardial infarction with this class of drugs seems to be similar to other hypoglycemic agents. PMID:21609444

  7. Brachytherapy versus prostatectomy in localized prostate cancer: Results of a French multicenter prospective medico-economic study

    SciTech Connect

    Buron, Catherine; Le Vu, Beatrice; Cosset, Jean-Marc; Peiffert, Didier; Delannes, Martine; Flam, Thierry; Guerif, Stephane; Salem, Naji; Chauveinc, Laurent; Livartowski, Alain . E-mail: alain.livartowski@curie.net

    2007-03-01

    Purpose: To prospectively compare health-related quality of life (HRQOL), patient-reported treatment-related symptoms, and costs of iodine-125 permanent implant interstitial brachytherapy (IB) with those of radical prostatectomy (RP) during the first 2 years after these treatments for localized prostate cancer. Methods and Materials: A total of 435 men with localized low-risk prostate cancer, from 11 French hospitals, treated with IB (308) or RP (127), were offered to complete the European Organization for Research and Treatment of Cancer core Quality of Life Questionnaire QLQ-C30 version 3 (EORTC QLQ-C30) and the prostate cancer specific EORTC QLQ-PR25 module before and at the end of treatment, 2, 6, 12, 18, and 24 months after treatment. Repeated measures analysis of variance and analysis of covariance were conducted on HRQOL changes. Comparative cost analysis covered initial treatment, hospital follow-up, outpatient and production loss costs. Results: Just after treatment, the decrease of global HRQOL was less pronounced in the IB than in the RP group, with a 13.5 points difference (p < 0.0001). A difference slightly in favor of RP was observed 6 months after treatment (-7.5 points, p = 0.0164) and was maintained at 24 months (-8.2 points, p = 0.0379). Impotence and urinary incontinence were more pronounced after RP, whereas urinary frequency, urgency, and urination pain were more frequent after IB. Mean societal costs did not differ between IB ( Euro 8,019 at T24) and RP ( Euro 8,715 at T24, p = 0.0843) regardless of the period. Conclusions: This study suggests a similar cost profile in France for IB and RP but with different HRQOL and side effect profiles. Those findings may be used to tailor localized prostate cancer treatments to suit individual patients' needs.

  8. Feasibility and performance study for a space-borne 1645nm OPO for French-German satellite mission MERLIN

    NASA Astrophysics Data System (ADS)

    Livrozet, Marie J.; Elsen, Florian; Wüppen, Jochen; Löhring, Jens; Büdenbender, Christian; Fix, Andreas; Jungbluth, Bernd; Hoffmann, Dieter

    2014-02-01

    We present a theoretical and experimental analysis of a pulsed 1645 nm optical parametric oscillator (OPO) conducted to prove the feasibility of such a device for a spaceborne laser transmitter in an integrated path differential absorption (IPDA) lidar system. The investigation is part of the French-German satellite mission MERLIN (Methane Remote Sensing Lidar Mission). As an effective greenhouse gas, methane plays an important role for the global climate. The architecture of the OPO is based on a conceptual design developed by DLR, consisting of two KTA crystals in a four-mirror-cavity. One of the cavity mirrors is piezo-driven to provide single frequency operation of the OPO. Using numerical simulations, we studied the performance and alignment tolerances of such a setup with KTP and KTA and investigated means to optimize the optical design by increasing the efficiency and decreasing the fluence on the optical components. For the experimental testing of the OPO, we used the INNOSlab-based ESA pre-development model ATLAS as pump laser at 1064 nm. At a pulse frequency of 25 Hz this MOPA delivers a pump energy up to 45 mJ with a beam quality factor of about M² = 1.3. With KTP as nonlinear crystal the OPO obtained 9.2 mJ pulse energy at 1645 nm from 31.5 mJ of the pump and a pump pulse duration of 42 ns. This corresponds to an optical/optical efficiency of 29%. After the pump pulse was reduced to 24 ns a similar OPO performance could be obtained by adapting the pump beam radius.

  9. Risk assessment in ramps for heavy vehicles--A French study.

    PubMed

    Cerezo, Veronique; Conche, Florence

    2016-06-01

    This paper presents the results of a study dealing with the risk for heavy vehicles in ramps. Two approaches are used. On one hand, statistics are applied on several accidents databases to detect if ramps are more risky for heavy vehicles and to define a critical value for longitudinal slope. χ(2) test confirmed the risk in ramps and statistical analysis proved that a longitudinal slope superior to 3.2% represents a higher risk for heavy vehicles. On another hand, numerical simulations allow defining the speed profile in ramps for two types of heavy vehicles (tractor semi-trailer and 2-axles rigid body) and different loads. The simulations showed that heavy vehicles must drive more than 1000 m on ramps to reach their minimum speed. Moreover, when the slope is superior to 3.2%, tractor semi-trailer presents a strong decrease of their speed until 50 km/h. This situation represents a high risk of collision with other road users which drive at 80-90 km/h. Thus, both methods led to the determination of a risky configuration for heavy vehicles: ramps with a length superior to 1000 m and a slope superior to 3.2%. An application of this research work concerns design methods and guidelines. Indeed, this study provides threshold values than can be used by engineers to make mandatory specific planning like a lane for slow vehicles.

  10. Prevalence and Treatment Management of Oropharyngeal Candidiasis in Cancer Patients: Results of the French Candidoscope Study

    SciTech Connect

    Gligorov, Joseph; Bastit, Laurent; Gervais, Honorine; Henni, Mehdi; Kahila, Widad; Lepille, Daniel; Luporsi, Elisabeth; Sasso, Giuseppe; Varette, Charles; Azria, David

    2011-06-01

    Purpose: The aim of this pharmaco-epidemiological study was to evaluate the prevalence of oropharyngeal candidiasis (OPC) in cancer patients treated with chemotherapy and/or radiotherapy. Methods and Materials: Signs and symptoms of OPC were noted for all patients. Antifungal therapeutic management was recorded in OPC patients. Patients receiving local antifungal treatments were monitored until the end of treatment. Results: Enrolled in the study were 2,042 patients with solid tumor and/or lymphoma treated with chemotherapy and/or another systemic cancer treatment and/or radiotherapy. The overall prevalence of OPC was 9.6% (95% confidence interval, 8.4%-11.0%]in this population. It was most frequent in patients treated with combined chemoradiotherapy (22.0%) or with more than two cytotoxic agents (16.9%). Local antifungal treatments were prescribed in 75.0% of OPC patients as recommended by guidelines. The compliance to treatment was higher in patients receiving once-daily miconazole mucoadhesive buccal tablet (MBT; 88.2%) than in those treated with several daily mouthwashes of amphotericin B (40%) or nystatin (18.8%). Conclusion: OPC prevalence in treated cancer patients was high. Local treatments were usually prescribed as per guidelines. Compliance to local treatments was better with once-daily drugs.

  11. Retrospective study of metal contamination time trends in the French part of the Bay of Biscay.

    PubMed

    Boutier, Bernard; Quintin, Jean-Yves; Rozuel, Emmanuelle; Dominique, Auger; Bretaudeau-Sanjuan, Jane

    2011-12-01

    Two cores were sampled in the Bay of Biscay: one a few miles off the Gironde estuary (pointe de la Coubre), the other near the Spanish border (Capbreton canyon) to study past variations in sediment contamination. Radiochronology (210Pb, 137Cs) and total metal determinations by ICP-MS allowed the study of time trends for metal concentrations in sediment. Off the Gironde, during the time interval recorded by the core (1958-1999), all metal concentrations remained less than OSPAR background values. Some variations occurred along the Cd and Zn profiles, which may correspond to a very attenuated signal from the Gironde outputs. This suggests that this area was not submitted to any significant anthropogenic input of metals between 1958 and 1999. In the canyon of Capbreton, the undisturbed part of the core recorded the influence of surface deposition between 1977 and 1999. From as early as 1977 high lead and mercury concentrations were noticed. Mercury concentrations increased until 1992, then decreased until 1999. This marks a drop of inputs in 1992, but the final concentration remained elevated. Lead had important concentrations (more than twice the OSPAR reference) all along the core and began to decrease only in the upper level of the unmixed layer. This shows a late (near 1998) drop of lead inputs. Other metals (Cd, Cu, Zn, Ni, Cr) stayed at a much lower level: less than the OSPAR reference for Cu, Cr and Ni or not far from the OSPAR reference for Cd and Zn.

  12. The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study

    PubMed Central

    Stengel, Bénédicte; Combe, Christian; Jacquelinet, Christian; Briançon, Serge; Fouque, Denis; Laville, Maurice; Frimat, Luc; Pascal, Christophe; Herpe, Yves-Edouard; Deleuze, Jean-François; Schanstra, Joost; Pisoni, Ron L.; Robinson, Bruce M.; Massy, Ziad A.

    2014-01-01

    Background While much has been learned about the epidemiology and treatment of end-stage renal disease (ESRD) in the last 30 years, chronic kidney disease (CKD) before the end-stage has been less investigated. Not enough is known about factors associated with CKD progression and complications, as well as its transition to ESRD. We designed the CKD-renal epidemiology and information network (REIN) cohort to provide a research platform to address these key questions and to assess clinical practices and costs in patients with moderate or advanced CKD. Methods A total of 46 clinic sites and 4 renal care networks participate in the cohort. A stratified selection of clinic sites yields a sample that represents a diversity of settings, e.g. geographic region, and public versus for-profit and non-for-profit private clinics. In each site, 60–90 patients with CKD are enrolled at a routine clinic visit during a 12-month enrolment phase: 3600 total, including 1800 with Stage 3 and 1800 with Stage 4 CKD. Follow-up will continue for 5 years, including after initiation of renal replacement therapy. Data will be collected from medical records at inclusion and at yearly intervals, as well as from self-administered patient questionnaires and provider-level questionnaires. Patients will also be interviewed at baseline, and at 1, 3 and 5 years. Healthcare costs will also be determined. Blood and urine samples will be collected and stored for future studies on all patients at enrolment and at study end, and at 1 and 3 years in a subsample of 1200. Conclusions The CKD-REIN cohort will serve to improve our understanding of the biological, clinical and healthcare system determinants associated with CKD progression and adverse outcomes as well as of international variations in collaboration with the CKD Outcome and Practice Pattern Study (CKDopps). It will foster CKD epidemiology and outcomes research and provide evidence to improve the health and quality of life of patients with CKD and

  13. How errors on meteorological variables impact simulated ecosystem fluxes: a case study for six French sites

    NASA Astrophysics Data System (ADS)

    Zhao, Y.; Ciais, P.; Peylin, P.; Viovy, N.; Longdoz, B.; Bonnefond, J. M.; Rambal, S.; Klumpp, K.; Olioso, A.; Cellier, P.; Maignan, F.; Eglin, T.; Calvet, J. C.

    2011-03-01

    We analyze how biases of meteorological drivers impact the calculation of ecosystem CO2, water and energy fluxes by models. To do so, we drive the same ecosystem model by meteorology from gridded products and by ''true" meteorology from local observation at eddy-covariance flux sites. The study is focused on six flux tower sites in France spanning across a 7-14 °C and 600-1040 mm yr-1 climate gradient, with forest, grassland and cropland ecosystems. We evaluate the results of the ORCHIDEE process-based model driven by four different meteorological models against the same model driven by site-observed meteorology. The evaluation is decomposed into characteristic time scales. The main result is that there are significant differences between meteorological models and local tower meteorology. The seasonal cycle of air temperature, humidity and shortwave downward radiation is reproduced correctly by all meteorological models (average R2=0.90). At sites located near the coast and influenced by sea-breeze, or located in altitude, the misfit of meteorological drivers from gridded dataproducts and tower meteorology is the largest. We show that day-to-day variations in weather are not completely well reproduced by meteorological models, with R2 between modeled grid point and measured local meteorology going from 0.35 (REMO model) to 0.70 (SAFRAN model). The bias of meteorological models impacts the flux simulation by ORCHIDEE, and thus would have an effect on regional and global budgets. The forcing error defined by the simulated flux difference resulting from prescribing modeled instead than observed local meteorology drivers to ORCHIDEE is quantified for the six studied sites and different time scales. The magnitude of this forcing error is compared to that of the model error defined as the modeled-minus-observed flux, thus containing uncertain parameterizations, parameter values, and initialization. The forcing error is the largest on a daily time scale, for which it is

  14. Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

    PubMed Central

    Blanc, Peggy; Dutronc, Hervé; Peuchant, Olivia; Dauchy, Frédéric-Antoine; Cazanave, Charles; Neau, Didier; Wirth, Gaëtane; Pellegrin, Jean-Luc; Morlat, Philippe; Mercié, Patrick; Tunon-de-Lara, José-Manuel; Doutre, Marie-Sylvie; Pélissier, Philippe; Dupon, Michel

    2016-01-01

    Background Nontuberculous mycobacteria (NTM) are environmental organisms associated with a range of infections. Reports of NTM epidemiology are mainly focused on pulmonary infections and isolations, and extrapulmonary infections are less frequently described. Methods We conducted a retrospective study of NTM infections at the Bordeaux University Hospital, France, between January 2002 and December 2013. We used the microbiologic component of the American Thoracic Society/Infectious Diseases Society of America's pulmonary NTM disease criteria to define cases of pulmonary NTM, and patients with isolates from a normally sterile site were classified as having extrapulmonary disease. Results In our setting, 170 patients were included. Pulmonary cases predominated (54.1%), followed by skin and soft tissue infections (22.9%), disseminated cases (10.6%), lymphadenitis (7.7%), bone and joint infections (2.9%) and the remaining 1.8% catheter-related infections. Overall, 16 NTM species were isolated. Mycobacterium avium (31.8%) and M. intracellulare (20%) were the most common species identified, followed by M. marinum (13.5%), M. kansasii (10.6%), M. xenopi (9.4%), rapidly growing mycobacteria (9.4%) and other slowly growing mycobacteria (5.3%). In general, NTM isolates were largely prevalent in people older than 50 (62.4%); patients aged 1–10 year-old exclusively yielded M. avium from lymph nodes, almost cases having being diagnosed after 2007. Among the 121 patients with complete follow-up, 78 (64.5%), 24 (19.8%), and 19 (15.7%) were cured, experienced relapse, or died, respectively. Conclusion In our study, extrapulmonary NTM infections represented almost half of cases, consisting mainly in skin and soft tissue infections. The increase lymphadenitis cases in children after 2007 could be linked to the cessation of mandatory BCG vaccination in France. We observed similar cure rates (64%) between pulmonary and extrapulmonary infections. PMID:27959960

  15. Nation-wide study of the occurrence of Listeria monocytogenes in French soils using culture-based and molecular detection methods.

    PubMed

    Locatelli, Aude; Depret, Géraldine; Jolivet, Claudy; Henry, Sonia; Dequiedt, Samuel; Piveteau, Pascal; Hartmann, Alain

    2013-06-01

    Soil is a potential reservoir of human pathogens and a possible source of contamination of animals, crops and water. In order to study the distribution of Listeria monocytogenes in French soils, a real-time PCR TaqMan assay targeting the phosphoribosylpyrophosphate synthetase (prs) gene of L. monocytogenes was developed for the specific detection and quantification of this bacterium within a collection of 1315 soil DNAs originated from the French Soil Quality Monitoring Network. The prs real-time PCR TaqMan assay was specific for L. monocytogenes and could quantify accurately down to 10(4)L. monocytogenes per gram of dry soil. Among the 1315 soil DNAs, prs was not detected. This suggested that the level of L. monocytogenes in French soils is generally less than 10(4)L. monocytogenes per gram of dry soil. In order to confirm this hypothesis, we investigated the occurrence of L. monocytogenes in samples collected in the Burgundy region by culture-based and molecular detection methods on the same samples. By using cultivation-based detection, 17% of samples were positive for the presence of L. monocytogenes while only 2% were found positive by the molecular detection method. L. monocytogenes was repeatedly isolated from cow pasture soils but not from cultivated soils, meadows or forest soils. Isolates were grouped in the serovar 1/2a or 3a and 4b or 4d or 4e. Taken as a whole, molecular detection results globally demonstrate that the level of L. monocytogenes in French soils does not exceed 10(4)CFU per gram of dry soil. However, in comparison with culture-based method, PCR-based detection underestimates the occurrence of L. monocytogenes in soils. Soil sampling procedure also appears critical and may also lead to the underestimation of the incidence of L. monocytogenes.

  16. Transportation noise and annoyance related to road traffic in the French RECORD study.

    PubMed

    Méline, Julie; Van Hulst, Andraea; Thomas, Frédérique; Karusisi, Noëlla; Chaix, Basile

    2013-10-02

    Road traffic and related noise is a major source of annoyance and impairment to health in urban areas. Many areas exposed to road traffic noise are also exposed to rail and air traffic noise. The resulting annoyance may depend on individual/neighborhood socio-demographic factors. Nevertheless, few studies have taken into account the confounding or modifying factors in the relationship between transportation noise and annoyance due to road traffic. In this study, we address these issues by combining Geographic Information Systems and epidemiologic methods. Street network buffers with a radius of 500 m were defined around the place of residence of the 7290 participants of the RECORD Cohort in Ile-de-France. Estimated outdoor traffic noise levels (road, rail, and air separately) were assessed at each place of residence and in each of these buffers. Higher levels of exposure to noise were documented in low educated neighborhoods. Multilevel logistic regression models documented positive associations between road traffic noise and annoyance due to road traffic, after adjusting for individual/neighborhood socioeconomic conditions. There was no evidence that the association was of different magnitude when noise was measured at the place of residence or in the residential neighborhood. However, the strength of the association between neighborhood noise exposure and annoyance increased when considering a higher percentile in the distribution of noise in each neighborhood. Road traffic noise estimated at the place of residence and road traffic noise in the residential neighborhood (75th percentile) were independently associated with annoyance, when adjusted for each other. Interactions of effects indicated that the relationship between road traffic noise exposure in the residential neighborhood and annoyance was stronger in affluent and high educated neighborhoods. Overall, our findings suggest that it is useful to take into account (i) the exposure to transportation noise

  17. A French crop-exposure matrix for use in epidemiological studies on pesticides: PESTIMAT.

    PubMed

    Baldi, Isabelle; Carles, Camille; Blanc-Lapierre, Audrey; Fabbro-Peray, Pascale; Druet-Cabanac, Michel; Boutet-Robinet, Elisa; Soulat, Jean-Marc; Bouvier, Ghislaine; Lebailly, Pierre

    2017-01-01

    Pesticide exposure assessment is a key methodological issue for epidemiological studies. The history of pesticide has proven difficult to obtain from individuals' report because of the wide range of active ingredients (AIs). We developed a crop-exposure matrix, which intends to reconstitute parameters of pesticide exposure in France since 1950. PESTIMAT is composed of tables crossing crops and AIs by year and providing the following metrics: (1) probability (proportion of farmers having used the AIs); (2) frequency (number of treatment days); and (3) intensity (application rate of the AIs in kg/ha). Metrics were obtained by the combination of six sources: (i) registration information from the Agriculture Ministry; (ii) information from agricultural bodies on products marketed; (iii) agricultural recommendations by the Plant Health Protection body; (iv) treatment calendars provided by farmers; (v) data from associations of farmers; and (vi) data from the industry. To date, 529 AIs usable between 1950 and 2010 are included in PESTIMAT: 160 fungicides; 160 herbicides; and 209 insecticides. When combined with duration and determinants of intensity, the metrics in PESTIMAT will make it possible to calculate exposure scores and to search for dose-effect relationships, an important criterion for causality judgment in epidemiology.

  18. French retrospective multicentric study of neonatal hemochromatosis: importance of autopsy and autoimmune maternal manifestations.

    PubMed

    Collardeau-Frachon, Sophie; Heissat, Sophie; Bouvier, Raymonde; Fabre, Monique; Baruteau, Julien; Broue, Pierre; Cordier, Marie-Pierre; Debray, Dominique; Debiec, Hanna; Ronco, Pierre; Guigonis, Vincent

    2012-01-01

    Neonatal hemochromatosis is a rare disease that causes fetal loss and neonatal death in the 1st weeks of life and is one of the most common causes of liver failure in the neonate. The diagnosis is mostly made retrospectively, based on histopathologic features of severe liver fibrosis associated with hepatic and extrahepatic siderosis. Several etiologies may underlie this phenotype, including a recently hypothesized gestational alloimmune disease. Fifty-one cases of liver failure with intrahepatic siderosis in fetuses and neonates were analyzed retrospectively. Maternal and infant data were collected from hospitalization and autopsy reports. All available slides were reviewed independently by 3 pathologists. Immunologic studies were performed on maternal sera collected immediately after delivery. The diagnosis of neonatal haemochromatosis was retained in 33 cases, including 1 case with Down syndrome and 1 case with myofibromas. Liver siderosis was inversely proportional to fibrosis progression. In fetuses, iron storage was more frequent in the thyroid than in the pancreas. Perls staining in labial salivary glands was positive in 1 of 5 cases. Abnormal low signal intensity by magnetic resonance imaging was detected in the pancreas in 2 of 7 cases. Renal tubular dysgenesis was observed in 7 of 23 autopsy cases. Chronic villitis was seen in 7 of 15 placentas. Half of the mothers presented with an autoimmune background and/or autoantibodies in their sera. Our work highlights the importance of autopsy in cases of neonatal hemochromatosis and marshals additional data in support of the hypothesis that neonatal hemochromatosis could reflect maternal immune system dysregulation.

  19. Electricity production by intermittent renewable sources: a synthesis of French and German studies

    NASA Astrophysics Data System (ADS)

    Grand, D.; Le Brun, Ch.; Vidil, R.; Wagner, F.

    2016-09-01

    Wind and solar electricity is produced without direct CO2 emissions. However, the introduction of this electricity in the grid is delicate due to the intermittent character of its sources. Wind and solar production is characterized by multiple, strong variations in the electric power. These variations put stress on the grid where the total production of electricity must always be equal to the consumption. We present a synthesis of five studies conducted for Germany and France with different assumptions of electricity mixes, all with large shares of wind and solar power. These mixes are subjected to the dynamics of wind and solar production as recorded in 2010 (Germany), 2012 and 2013 (Germany and France). Common structural trends are exhibited when the results of simulations (instantaneous power distributions and average annual values) are expressed as a percentage of the annual reduced load to be produced by these intermittent energies. We focus on the evaluation of these trends and the resulting constraints on the grid. The results obtained make it possible to anticipate the problems brought about by a large share of renewable intermittent energies in the production of electricity. They show the need for backup production in order to complement the intermittent sources. This leads to CO2 emissions unless storage systems of large capacity are available.

  20. Skiing in French.

    ERIC Educational Resources Information Center

    Moeller, Paulette

    1984-01-01

    A high school French program conducted entirely in French on local ski slopes is based on the philosophy that language is a social tool for communicative purposes and can best be learned in social interaction. The successful program uses teamwork, an open attitude toward language learning, non-stressful evaluation, and innovative techniques. (MSE)

  1. The French Revolution.

    ERIC Educational Resources Information Center

    Baltimore City Public Schools, MD.

    This outline on the French Revolution is designed to illustrate how this period of French history influenced various aspects of contemporary culture. Four main sections are treated: (1) ideas that led to the Revolution, (2) the reigns of the Bourbon kings, (3) the Revolution, and (4) the rise of Napoleon as a reaction to chaos. A list of 16mm…

  2. Demythifying French Grammar.

    ERIC Educational Resources Information Center

    Bryant, William H.

    1984-01-01

    Focuses on several myths and fallacies prevalent in the field of French grammar. The importance of keeping up-to-date with language and grammatical usage is stressed, since the rules of language do change. Thus, the validity of the linguistic content of French grammar books must be questioned, so that any outmoded or invalid concepts can be…

  3. Illustrated French Idioms.

    ERIC Educational Resources Information Center

    Ainsa, Serge M.

    Designed to promote an awareness of the everyday French language, this supplementary textbook was developed to enable students of French to use idiomatic expressions from the early learning stages to the more advanced levels. The units are arranged as follows according to the verb component of the expression: "avoir,""etre,""faire," the three…

  4. Digestive-tract sarcoidosis: French nationwide case-control study of 25 cases.

    PubMed

    Ghrenassia, Etienne; Mekinian, Arsene; Chapelon-Albric, Catherine; Levy, Pierre; Cosnes, Jacques; Sève, Pascal; Lefèvre, Guillaume; Dhôte, Robin; Launay, David; Prendki, Virginie; Morell-Dubois, Sandrine; Sadoun, Danielle; Mehdaoui, Anas; Soussan, Michael; Bourrier, Anne; Ricard, Laure; Benamouzig, Robert; Valeyre, Dominique; Fain, Olivier

    2016-07-01

    Digestive tract sarcoidosis (DTS) is rare and case-series are lacking. In this retrospective case-control study, we aimed to compare the characteristics, outcome, and treatment of patients with DTS, nondigestive tract sarcoidosis (NDTS), and Crohn disease.We included cases of confirmed sarcoidosis, symptomatic digestive tract involvement, and noncaseating granuloma in any digestive tract. Each case was compared with 2 controls with sarcoidoisis without digestive tract involvement and 4 with Crohn disease.We compared 25 cases of DTS to 50 controls with NDTS and 100 controls with Crohn disease. The major digestive clinical features were abdominal pain (56%), weight loss (52%), nausea/vomiting (48%), diarrhea (32%), and digestive bleeding (28%). On endoscopy of DTS, macroscopic lesions were observed in the esophagus (9%), stomach (78%), duodenum (9%), colon, (25%) and rectum (19%). As compared with NDTS, DTS was associated with weight loss (odds ratio [OR] 5.8; 95% confidence interval [CI] 1.44-23.3) and the absence of thoracic adenopathy (OR 5.0; 95% CI 1.03-25). As compared with Crohn disease, DTS was associated with Afro-Caribbean origin (OR 27; 95% CI 3.6-204) and the absence of ileum or colon macroscopic lesions (OR 62.5; 95% CI 10.3-500). On the last follow-up, patients with DTS showed no need for surgery (versus 31% for patients with Crohn disease; P = 0.0013), and clinical digestive remission was frequent (76% vs. 35% for patients with Crohn disease; P = 0.0002).The differential diagnosis with Crohn disease could be an issue with DTS. Nevertheless, the 2 diseases often have different clinical presentation and outcome.

  5. Cutaneous Invasive Aspergillosis: Retrospective Multicenter Study of the French Invasive-Aspergillosis Registry and Literature Review.

    PubMed

    Bernardeschi, Céline; Foulet, Francoise; Ingen-Housz-Oro, Saskia; Ortonne, Nicolas; Sitbon, Karine; Quereux, Gaëlle; Lortholary, Olivier; Chosidow, Olivier; Bretagne, Stéphane

    2015-07-01

    Invasive aspergillosis (IA) has poor prognosis in immunocompromised patients. Skin manifestations, when present, should contribute to an early diagnosis. The authors aimed to provide prevalence data and a clinical and histologic description of cutaneous manifestations of primary cutaneous IA (PCIA) and secondary CIA (SCIA) in a unique clinical series of IA and present the results of an exhaustive literature review of CIA. Cases of proven and probable IA with cutaneous manifestations were retrospectively extracted from those registered between 2005 and 2010 in a prospective multicenter aspergillosis database held by the National Reference Center for Invasive Mycoses and Antifungals, Pasteur Institute, France. Patients were classified as having PCIA (i.e., CIA without extracutaneous manifestations) or SCIA (i.e., disseminated IA). Among the 1,410 patients with proven or probable IA, 15 had CIA (1.06%), 5 PCIA, and 10 SCIA. Hematological malignancies were the main underlying condition (12/15). Patients with PCIA presented infiltrated and/or suppurative lesions of various localizations not related to a catheter site (4/5), whereas SCIA was mainly characterized by disseminated papules and nodules but sometimes isolated nodules or cellulitis. Histologic data were available for 11 patients, and for 9, similar for PCIA and SCIA, showed a dense dermal polymorphic inflammatory infiltrate, with the epidermis altered in PCIA only. Periodic acid Schiff and Gomori-Grocott methenamine silver nitrate staining for all but 2 biopsies revealed hyphae compatible with Aspergillus. Aspergillus flavus was isolated in all cases of PCIA, with Aspergillus fumigatus being the most frequent species (6/10) in SCIA. Two out 5 PCIA cases were treated surgically. The 3-month survival rate was 100% and 30% for PCIA and SCIA, respectively. Our study is the largest adult series of CIA and provides complete clinical and histologic data for the disease. Primary cutaneous IA should be recognized early

  6. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

    PubMed Central

    Küry, Sébastien; Buecher, Bruno; Robiou-du-Pont, Sébastien; Scoul, Catherine; Colman, Hélène; Le Neel, Tanguy; Le Houérou, Claire; Faroux, Roger; Ollivry, Jean; Lafraise, Bernard; Chupin, Louis-Dominique; Sébille, Véronique; Bézieau, Stéphane

    2008-01-01

    Background Sporadic colorectal cancers (CRC) are multifactorial diseases resulting from the combined effects of numerous genetic, environmental and behavioral risk factors. Genetic association studies have suggested low-penetrance alleles of extremely varied genes to be involved in susceptibility to CRC in Caucasian populations. Methods Through a large genetic association study based on 1023 patients with sporadic CRC and 1121 controls, we tested a panel of these low-penetrance alleles to find out whether they could determine "genotypic profiles" at risk for CRC among individuals of the French population. We examined 52 polymorphisms of 35 genes – drawn from inflammation, xenobiotic detoxification, one-carbon, insulin signaling, and DNA repair pathways – for their possible contribution to colorectal carcinogenesis. The risk of cancer associated with these polymorphisms was assessed by calculation of odds ratios (OR) using multivariate analyses and logistic regression. Results Whereas all these polymorphisms had previously been found to be associated with CRC risk, especially in Caucasian populations, we were able to replicate the association for only five of them. Three SNPs were shown to increase CRC risk: PTGS1 c.639C>A (p.Gly213Gly), IL8 c.-352T>A, and MTHFR c.1286A>C (p.Ala429Glu). On the contrary, two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T (p.His477His), were associated with a decrease in CRC risk. Further analyses highlighted genotypic combinations having a greater predisposing effect on CRC (OR 1.97, 95%CI 1.31–2.97, p = 0.0009) than the allelic variants that were examined separately. Conclusion The identification of CRC-predisposing combinations, composed of alleles PTGS1 c.639A, PLA2G2A c.435+230C, PPARG c.1431C, IL8 c.-352A, and MTHFR c.1286C, highlights the importance of inflammatory processes in susceptibility to sporadic CRC, as well as a possible crosstalk between inflammation and one-carbon pathways. PMID:18992148

  7. Analysis of Stream Channel Geometry Temporal and Spatial Evolution after Historic Dam Removal - two French case studies

    NASA Astrophysics Data System (ADS)

    Slawson, Deborah; Manière, Louis; Marchandeau, Florent

    2014-05-01

    IRSTEA, in partnership with the French Office national de l'eau et des milieux aquatiques (ONEMA), has begun a study of channel geomorphology in small streams where dams have been removed or breached between two and 200 years ago, without any subsequent restoration of the channel in the legacy sediments. A preliminary analysis of two sites in the Morvan, Burgundy, will be presented; a dam breached at the beginning of the 20th century and another in the last decade. Using ergodic reasoning, historical and recent upstream and downstream channel geometry is being used to predict the future temporal and spatial scales of channel physical habitat restoration. With the implementation of the European Water Framework Directive (WFD), dam removal has become a more frequently used method for restoring stream ecological continuity. In France, these obstacles are ubiquitous in medium and small streams and considerably reduce lateral and longitudinal connectivity. Improvement in the hydromorphologically controlled, physical habitat, particularly flow and sediment transport regimes, is often essential to improvement in stream biology. However, dam removal may cause long-term disturbances in flow and sediment transport regimes. In the absence of channel restoration measures in addition to dam removal, these disturbances may result in long-term negative impacts on fish, macroinvertebrate, and riparian plant physical habitat. These negative impacts may include channel incision and lowering of the water table, disconnection from floodplains, increased stream power and bed scouring, and increased sediment load from headcutting and bank erosion. Over time, these negative impacts may resolve themselves. However, the time frame necessary for reestablishing adequate physical habitat is not well-known. Some studies have indicated that many decades or longer may be required, depending on a variety of factors. Under the WFD, the REstoring rivers FOR effective catchment Management (REFORM

  8. Chine: Les Chances du Francais (The Fortunes of the French Language in China).

    ERIC Educational Resources Information Center

    Shuning, Zhang

    1996-01-01

    Examines the current situation in China surrounding the teaching of French as a Foreign Language. After the decline of French teaching subsequent to the Cultural Revolution, the language returned to favor around 1970. Chinese students are infatuated with French; many study it as a first or second foreign language. Additionally, French literature…

  9. Call Me "Madame": Re-Presenting Culture in the French Language Classroom

    ERIC Educational Resources Information Center

    Siskin, H. Jay

    2007-01-01

    This study examines autobiographies of American teachers of French in order to make explicit their beliefs regarding French language and culture. The themes of class and power are prominent in these teachers' belief systems, as is the desire for self-transformation through mastery of French and miming a subset of French behaviors. These notions…

  10. Immersion Education in the Context of an Endangered Language: A Linguistic Study of the Oral Production of French Immersion Students in Louisiana

    ERIC Educational Resources Information Center

    Betters, Jennifer R.

    2016-01-01

    In the past century, French has shifted from being the native language of many Louisianans to being an endangered dialect. Since the creation of the state agency CODOFIL (Council for the Development of French in Louisiana) in the 1960's, efforts have been made to revitalize French in Louisiana, and since the 1980's, some parishes have offered…

  11. A Local Evaluation of Primary School French

    ERIC Educational Resources Information Center

    Nisbet, J. D.; Welsh, Jennifer

    1972-01-01

    A local study concludes that primary school French does not confer a lasting advantage but its contribution lies in the enlargement of interest rather that as a preparation for secondary school work. (JB)

  12. Important Variables When Screening for Students at Suicidal Risk: Findings from the French Cohort of the SEYLE Study

    PubMed Central

    Kahn, Jean-Pierre; Tubiana, Alexandra; Cohen, Renaud F.; Carli, Vladimir; Wasserman, Camilla; Hoven, Christina; Sarchiapone, Marco; Wasserman, Danuta

    2015-01-01

    Due to early detection of mental ill-health being an important suicide preventive strategy, the multi-centre EU funded “Saving and Empowering Young Lives in Europe” (SEYLE) study compared three school-based mental health promotion programs to a control group. In France, 1007 students with a mean age of 15.2 years were recruited from 20 randomly assigned schools. This paper explores the French results of the SEYLE’s two-stage screening program (ProfScreen) and of the cross-program suicidal emergency procedure. Two-hundred-thirty-five ProfScreen students were screened using 13 psychopathological and risk behaviour scales. Students considered at risk because of a positive finding on one or more scales were offered a clinical interview and, if necessary, referred for treatment. A procedure for suicidal students (emergency cases) was set up to detect emergencies in the whole cohort (n = 1007). Emergency cases were offered the same clinical interview as the ProfScreen students. The interviewers documented their reasons for referrals in a short report. 16,2% of the ProfScreen students (38/235) were referred to treatment and 2,7% of the emergency cases (27/1007) were also referred to treatment due to high suicidal risk. Frequent symptoms in those students referred for evaluation were depression, alcohol misuse, non-suicidal self-injuries (NSSI), and suicidal behaviours. According to the multivariate regression analysis of ProfScreen, the results show that the best predictors for treatment referral were NSSI (OR 2.85), alcohol misuse (OR 2.80), and depressive symptoms (OR 1.13). Analysis of the proportion for each scale of students referred to treatment showed that poor social relationships (60%), anxiety (50%), and suicidal behaviours (50%) generated the highest rate of referrals. Qualitative analysis of clinician’s motivations to refer a student to mental health services revealed that depressive symptoms (51%), anxiety (38%), suicidal behaviours (40%), and

  13. Epidemiology of sociodemographic characteristics, lifestyle, medical history, and colon cancer: a case-control study among French Canadians in Montreal.

    PubMed

    Ghadirian, P; Maisonneuve, P; Perret, C; Lacroix, A; Boyle, P

    1998-01-01

    Colon cancer is the second most common cancer in both men and women in North America and other developed countries. In a population-based case-control study of colon cancer among French Canadians in greater Montreal, a total of 402 cases and 668 controls were interviewed. The cancer cases were identified through the admission offices of five major Francophone teaching hospitals in Montreal from 1989 to 1993. The controls, matched by age, sex, place of residence, and language, were selected by a modified random digit dialing method. The results show that subjects who had ever been married had a lower risk for colon cancer (odds ratio [OR]: 0.58; 95% confidence interval [95% CI]: 0.48-0.84) than did individuals who had never been married. A significant association (OR: 1.90; p for trend = 0.003) was found between the height of subjects and the risk of colon cancer. The OR for individuals with a family history of colorectal cancer was 2.78 with a p value of 0.01. A direct and significant association (OR: 2.01) was found among constipation, use of laxatives (OR: 1.41), and the risk of colon cancer. Among women, a suggestive inverse association was detected between the number of full-term pregnancies and the risk of colon cancer in female subjects (the OR for five or more pregnancies was 0.58 with a p for trend of 0.08). There was also a suggestive linear trend (increased age-decreased risk) between age at menarche and the risk of colon cancer. No association was apparent between other sociodemographic characteristics and the risk of colon cancer. In conclusion, married individuals had lower risk for colon cancer, perhaps due to food habits or other characteristics of being single. Higher height and weight history 10 years before the diagnosis of cancer are risk factors for breast cancer, while both current weight and body mass index seem to be protective. Positive family history of colon cancer increased the risk of colon cancer significantly.

  14. French for Business and Journalism

    ERIC Educational Resources Information Center

    Lacombe, Anne

    1977-01-01

    A description of a university course in French whose object is to give students some facility in current French as found in newspapers, magazines, radio and films; and to introduce them to contemporary French civilization. Methods used are reading, translation, synopsis writing, correspondence and interviews. (Text is in French.) (AMH)

  15. Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme

    PubMed Central

    Delzor, Aurélie; Couratier, Philippe; Boumédiène, Farid; Nicol, Marie; Druet-Cabanac, Michel; Paraf, François; Méjean, Annick; Ploux, Olivier; Leleu, Jean-Philippe; Brient, Luc; Lengronne, Marion; Pichon, Valérie; Combès, Audrey; El Abdellaoui, Saïda; Bonneterre, Vincent; Lagrange, Emmeline; Besson, Gérard; Bicout, Dominique J; Boutonnat, Jean; Camu, William; Pageot, Nicolas; Juntas-Morales, Raul; Rigau, Valérie; Masseret, Estelle; Abadie, Eric; Preux, Pierre-Marie; Marin, Benoît

    2014-01-01

    Introduction Amyotrophic lateral sclerosis (ALS) is the most common motor neurone disease. It occurs in two forms: (1) familial cases, for which several genes have been identified and (2) sporadic cases, for which various hypotheses have been formulated. Notably, the β-N-methylamino-L-alanine (L-BMAA) toxin has been postulated to be involved in the occurrence of sporadic ALS. The objective of the French BMAALS programme is to study the putative link between L-BMAA and ALS. Methods and analysis The programme covers the period from 1 January 2003 to 31 December 2011. Using multiple sources of ascertainment, all the incident ALS cases diagnosed during this period in the area under study (10 counties spread over three French regions) were collected. First, the standardised incidence ratio will be calculated for each municipality under concern. Then, by applying spatial clustering techniques, overincidence and underincidence zones of ALS will be sought. A case–control study, in the subpopulation living in the identified areas, will gather information about patients’ occupations, leisure activities and lifestyle habits in order to assess potential risk factors to which they are or have been exposed. Specimens of drinking water, food and biological material (brain tissue) will be examined to assess the presence of L-BMAA in the environment and tissues of ALS cases and controls. Ethics and dissemination The study has been reviewed and approved by the French ethical committee of the CPP SOOM IV (Comité de Protection des Personnes Sud-Ouest & Outre-Mer IV). The results will be published in peer-reviewed journals and presented at national and international conferences. PMID:25180055

  16. Teaching Middle School French

    ERIC Educational Resources Information Center

    Olson, Marilyn L.

    1975-01-01

    Author described some of the techniques she used for teaching French at Roosevelt Junior High School, West Palm Beach. She also explained how these techniques helped students to maintain an early desire to learn a foreign language. (Author/RK)

  17. The French Strategic Dilemma.

    DTIC Science & Technology

    1984-03-01

    crisis . The language of French strategic doctrine is that of dissuasion (deterrence). The French talk publicly much less about warfighting (and employment...threaten vital lines of supply in a crisis situation. Nuclear forces would not *-"e necessarily be useful In deterring Soviet actions in this regard. Rather...34 in Pierre Lellouche, ed., Pacifisme et Dissuasion (Paris: Economica , 1983), pp. 253-266. C. % 6. See Pierre Lacoste, Strategie Navale (Paris: Fernand

  18. The longitudinal development of clusters in French.

    PubMed

    Demuth, Katherine; McCullough, Elizabeth

    2009-03-01

    Studies of English and German find that children tend to acquire word-final consonant clusters before word-initial consonant clusters. This order of acquisition is generally attributed to articulatory, frequency and/or morphological factors. This contrasts with recent experimental findings from French, where two-year-olds were better at producing word-initial than word-final clusters (Demuth & Kehoe, 2006). The purpose of the present study was to examine French-speaking children's longitudinal acquisition of clusters to determine if these results replicate developmentally. Analysis of spontaneous speech productions from two French-speaking children between one and three years confirmed the earlier acquisition of initial clusters, even when sonority factors were controlled. The findings suggest that French-speaking children acquire complexity at the beginnings of words before complexity appears word-finally. The role of frequency, morphological, structural and input factors is discussed.

  19. Food and nutrient intakes of French frequent seafood consumers with regard to fish consumption recommendations: results from the CALIPSO study.

    PubMed

    Sirot, Véronique; Dumas, Céline; Leblanc, Jean-Charles; Margaritis, Irène

    2011-05-01

    Besides providing n-3 fatty acids with nutritional and health benefits, seafood consumption may contribute to the reduction of nutrient prevalences of inadequacy. To evaluate the contributions of seafood and other food groups to nutrient intakes of frequent seafood consumers, food consumption was evaluated through an FFQ on 991 French men and women (18-81 years) consuming seafood at least twice a week. Intakes, prevalence of inadequacies, risks of upper limit excess and food contributions to intakes were assessed for thirty-three nutrients. Mean fat contributions to total energy intakes (38·3 and 39·0 % for men and women, respectively) met French recommendations, but mean carbohydrate intakes (40·9 and 39·7 %, respectively) were insufficient. Micronutrient inadequacies were lower than in the French general population, the highest being for vitamin C (41·3 and 40·1 % for men and women, respectively), vitamin E (35·0 and 35·3 % for men and women, respectively) and Mg (37·5 and 25·5 % for men and women, respectively). Upper safety limits (USL) were exceeded mostly for Zn (6·2 %), Ca (3·7 %), retinol (2·0 %) and Cu (0·9 %). Mean contributions of seafood to vitamin D, B12, I and Se intakes ranged 40-65 %. Molluscs and crustaceans significantly contributed to vitamin B12 (13·7 %), Cu (11·4 %), Fe (11·5 %), Zn (8·4 %) and I (6·1 %) intakes, and canned fish contributed to vitamin D intake (13·4 %). Besides fish, contributions of mollusc and crustacean consumption to nutrient intakes should be considered from a public health viewpoint. Consuming seafood at least twice a week induces moderate inadequacies and risks of exceeding USL for some micronutrients, whereas macronutrient intakes remained imbalanced.

  20. [The French lessons of anatomy].

    PubMed

    Bouchet, Alain

    2003-01-01

    The "Lessons of Anatomy" can be considered as a step of Medicine to Art. For several centuries the exhibition of a corpse's dissection was printed on the title-page of published works. Since the seventeenth century, the "Lessons of Anatomy" became a picture on the title-page in order to highlight the well-known names of the european anatomists. The study is limited to the French Lessons of Anatomy found in books or pictures after the invention of printing.

  1. Venus transits - A French view

    NASA Astrophysics Data System (ADS)

    Débarbat, Suzanne

    2005-04-01

    After a careful study of Mars observations obtained by Tycho Brahé (1546-1601), Kepler (1571-1630) discovered the now-called Kepler's third law. In 1627 he published his famous Tabulae Rudolphinae, a homage to his protector Rudolph II (1552-1612), tables (Kepler 1609, 1627) from which he predicted Mercury and Venus transits over the Sun. In 1629 Kepler published his Admonitio ad Astronomos Advertisement to Astronomers (Kepler 1630), Avertissement aux Astronomes in French Au sujet de phénomènes rares et étonnants de l'an 1631: l'incursion de Vénus et de Mercure sur le Soleil. This was the beginning of the interest of French astronomers, among many others, in such transits, mostly for Venus, the subject of this paper in which dates are given in the Gregorian calendar.

  2. Studies of radon-exposed miner cohorts using a biologically based model: comparison of current Czech and French data with historic data from China and Colorado.

    PubMed

    Heidenreich, W F; Tomásek, L; Rogel, A; Laurier, D; Tirmarche, M

    2004-12-01

    The biologically based two-stage clonal expansion (TSCE) model is used to analyze lung cancer in several miners studies, two new ones (Czech, French) and two historic ones (Chinese, Colorado). In all cases, the model assumptions are identical. An action of radiation on initiation, promotion, and transformation is allowed. While all four studies indicate a highly significant action of radiation on promotion, the action on initiation is not significant in the French cohort, and barely significant in the Colorado miners cohort. No action on transformation is found in the Colorado miners, while the other data sets indicate a borderline significance. The model can describe all the data sets adequately, with different model parameters. The observed patterns in exposure, time since beginning of exposure, birth year, age and calendar year are reproduced well. The doubling exposure rate for initiation is about 3.5 WLM/year in the new data sets, while it is higher in the historic data sets. For transformation the doubling rate is about 20 WLM/year for the new data sets, while again the historic data give higher estimates. The action of radiation on promotion is quite different in the four data sets. These differences also induce different risk estimates at low exposures. The larger power of the new studies at these low exposures, compared to the historic data requires less extrapolation when the risk at very low exposures is estimated.

  3. Contribution of Organic Food to the Diet in a Large Sample of French Adults (the NutriNet-Santé Cohort Study)

    PubMed Central

    Baudry, Julia; Méjean, Caroline; Allès, Benjamin; Péneau, Sandrine; Touvier, Mathilde; Hercberg, Serge; Lairon, Denis; Galan, Pilar; Kesse-Guyot, Emmanuelle

    2015-01-01

    In developed countries, the demand for organic products continues to substantially increase each year. However, little information is available regarding the level of consumption of organic food and its relative share of the whole diet. Our aim was to provide, using individual consumption data, a detailed description of organic food consumption among French adults. Conventional and organic intakes were assessed using an organic food frequency questionnaire administered to 28,245 French adults participating in the NutriNet-Santé study. P values of Student t-test or Chi-square for the difference between genders were reported. Less than 12% of the respondents reported never consuming organic food in the past year. Women consumed on average 20% organic food in their whole diet per day while men consumed an average of 18%. The proportion of vegetables consumed that came from organic sources was 31% among women and 28% among men. Overall, the estimate of the contribution of organic food from products of plant origin was higher than that from products of animal origin. Our study provides a framework for the exploration of organic consumption and its correlates and can serve as a basis for future studies investigating relationships between the level of organic food consumption and health outcomes. PMID:26506372

  4. A new set of 299 pictures for psycholinguistic studies: French norms for name agreement, image agreement, conceptual familiarity, visual complexity, image variability, age of acquisition, and naming latencies.

    PubMed

    Bonin, Patrick; Peereman, Ronald; Malardier, Nathalie; Méot, Alain; Chalard, Marylène

    2003-02-01

    Pictures are often used as stimuli in studies of perception, language, and memory. Since performances on different sets of pictures are generally contrasted, stimulus selection requires the use of standardized material to match pictures across different variables. Unfortunately, the number of standardized pictures available for empirical research is rather limited. The aim of the present study is to provide French normative data for a new set of 299 black-and-white drawings. Alario and Ferrand (1999) were closely followed in that the pictures were standardized on six variables name agreement, image agreement, conceptual familiarity, visual complexity, image variability, and age of acquisition. Objective frequency measures are also provided for themost common names associated with the pictures. Comparative analyses between our results and the norms obtained in other, similar studies are reported. Finally, naming latencies corresponding to the set of pictures were also collected from French native speakers, and correlational/multiple-regression analyses were performed on naming latencies. This new set of standardized pictures is available on the Internet (http://leadserv.u-bourgogne.fr/bases/pictures/) and should be of great use to researchers when they select pictorial stimuli.

  5. Contribution of Organic Food to the Diet in a Large Sample of French Adults (the NutriNet-Santé Cohort Study).

    PubMed

    Baudry, Julia; Méjean, Caroline; Allès, Benjamin; Péneau, Sandrine; Touvier, Mathilde; Hercberg, Serge; Lairon, Denis; Galan, Pilar; Kesse-Guyot, Emmanuelle

    2015-10-21

    In developed countries, the demand for organic products continues to substantially increase each year. However, little information is available regarding the level of consumption of organic food and its relative share of the whole diet. Our aim was to provide, using individual consumption data, a detailed description of organic food consumption among French adults. Conventional and organic intakes were assessed using an organic food frequency questionnaire administered to 28,245 French adults participating in the NutriNet-Santé study. P values of Student t-test or Chi-square for the difference between genders were reported. Less than 12% of the respondents reported never consuming organic food in the past year. Women consumed on average 20% organic food in their whole diet per day while men consumed an average of 18%. The proportion of vegetables consumed that came from organic sources was 31% among women and 28% among men. Overall, the estimate of the contribution of organic food from products of plant origin was higher than that from products of animal origin. Our study provides a framework for the exploration of organic consumption and its correlates and can serve as a basis for future studies investigating relationships between the level of organic food consumption and health outcomes.

  6. The French version of the autism-spectrum quotient in adolescents: a cross-cultural validation study.

    PubMed

    Sonié, Sandrine; Kassai, Behrouz; Pirat, Elodie; Bain, Paul; Robinson, Janine; Gomot, Marie; Barthélémy, Catherine; Charvet, Dorothée; Rochet, Thierry; Tatou, Mohamed; Assouline, Brigitte; Cabrol, Stéphane; Chabane, Nadia; Arnaud, Valérie; Faure, Patricia; Manificat, Sabine

    2013-05-01

    We assessed the accuracy of the French version of the Autism Spectrum Quotient (AQ) in adolescents with Asperger syndrome (AS) and high-functioning autism (HFA) compared to healthy controls and adolescents with psychiatric disorders (PDs). Three groups of adolescents, aged 11-18, were assessed: 116 with AS/HFA (93 with IQ ≥ 85 and 20 with 70 ≤ IQ < 85), 39 with other PDs, and 199 healthy controls. The AS/HFA group scored significantly higher than the healthy control and PD groups. A cut-off score of 26 was used to differentiate the autism group from healthy controls with 0.89 sensitivity and 0.98 specificity. Scores did not vary by age or sex.

  7. Translating Word-Play: French-English, English-French.

    ERIC Educational Resources Information Center

    Gordon, W. Terrence

    1986-01-01

    The linguistic complexity of humor is illustrated with examples of word play translated from French to English and English to French. Examples from the writings of James Joyce and Marcel Proust are highlighted. (CB)

  8. Understanding of others' knowledge in French and Japanese children: a comparative study with a disambiguation task on 16-38-month-olds.

    PubMed

    Norimatsu, H; Blin, R; Hashiya, K; Sorsana, Ch; Kobayashi, H

    2014-11-01

    In order to explain the cultural differences reported in the results of false-belief tasks, we attempted to verify the 'task bias hypothesis' suggested by certain studies (e.g. Tardif et al. (2004). Journal of Child Language, 31, 779-800; Rubio-Fernandez & Geurts (2013). Psychological Science, 24(1), 27-33. doi 10.1177/0956797612447819). At the same time, we aimed to observe the theory of mind (ToM) ability of infants and young children under the age of three in verbal communication. To this end, we propose a new protocol to test young children's ToM ability, with particular attention paid to the linguistic aspect of the task. This original disambiguation task using proper nouns (first names) was tested on a total of 32 children aged between 16 and 38 months, in France and Japan. The results revealed that after the age of 30 months children begin to correctly interpret nouns while simultaneously taking into account their partner's knowledge (50% of the French and 29% of the Japanese children were successful), whereas this remains difficult for younger children (no child under 30 months was successful). The analysis of error types has shown that 'memory bias' was dominant in younger children in particular and 'association bias' was rarely observed across all ages. Given that the results of French and Japanese children did not differ significantly, we assume that this new task design could minimise the influence of cultural difference caused by the characteristics of different languages.

  9. Description of the type of chemical restraint used by French veterinarians to perform hip dysplasia screening radiographs. A retrospective study based on 3302 radiographs.

    PubMed

    Maitre, P; Genevois, J-P; Remy, D; Carozzo, C; Arnault, F; Buttin, P; Viguier, E; Fau, D

    2010-01-01

    The objective of this study was to investigate the type of chemical restraint used by French practitioners to perform official hip screening radiographs, to determine the proportion of dogs under general anesthesia versus dogs under sedation, and to search for a difference in hip dysplasia (HD) prevalence between the two groups. From September 2005 to August 2008, 3302 conventional ventrodorsal hip extended radiographs sent for official scoring to the same panellist were selected because information related to the type of chemical restraint had been provided. There were 2825 dogs under general anesthesia and 477 were sedated. Chemical restraint used by French veterinarians to perform HD screening radiographs is mainly based on general intra-venous anesthesia with an alpha2 agonist associated with ketamine. A single injection of alpha2 agonist is also mostly used for dogs which are radiographed while under sedation. A very low (1.7%) difference in HD prevalence was noted between the anesthetized and the sedated group. Except for acepromazine, which has been demonstrated to provide insufficient muscle relaxation to show evidence of hip laxity, the protocols seem acceptable as regards the Federation Cynologique Internationale requirements for HD screening.

  10. Mid-life occupational grade and quality of life following retirement: a 16-year follow-up of the French GAZEL study

    PubMed Central

    Platts, Loretta G.; Webb, Elizabeth; Zins, Marie; Goldberg, Marcel; Netuveli, Gopalakrishnan

    2015-01-01

    Objectives: This article aims to contribute to the literature on life course influences upon quality of life by examining pathways linking social position in middle age to quality of life following retirement in French men and women. Method: Data are from the GAZEL cohort study of employees at the French national gas and electricity company. A finely grained measure of occupational grade in 1989 was obtained from company records. Annual self-completion questionnaires provided information on quality of life in 2005, measured with the CASP-19 scale, and on participants’ recent circumstances 2002–2005: mental health, physical functioning, wealth, social status, neighbourhood characteristics, social support and social participation. Path analysis using full information maximum likelihood estimation was performed on 11,293 retired participants. Results: Higher occupational grade in 1989 was associated, in a graded relationship, with better quality of life 16 years later. This association was accounted for by individuals’ more recent circumstances, particularly their social status, mental health, physical functioning and wealth. Conclusion: The graded relationship between occupational grade in mid-life and quality of life after labour market exit was largely accounted for by more recent socio-economic circumstances and state of health. The results support a pathway model for the development of social disparities in quality of life, in which earlier social position shapes individual circumstances in later life. PMID:25220504

  11. Drug interactions between antihypertensive drugs and non-steroidal anti-inflammatory agents: a descriptive study using the French Pharmacovigilance database.

    PubMed

    Fournier, Jean-Pascal; Sommet, Agnès; Durrieu, Geneviève; Poutrain, Jean-Christophe; Lapeyre-Mestre, Maryse; Montastruc, Jean-Louis

    2014-04-01

    Drug-drug interactions (DDIs) between antihypertensive drugs and non-steroidal anti-inflammatory drugs (NSAIDs) can lead to adverse drug reactions (ADRs). Guidelines are available to help prescribers deal with these drug associations, but their implementation is not well evaluated. The aims of this study were to assess the prevalence of NSAIDs exposure in patients treated with antihypertensive drugs, using the French Pharmacovigilance database, and explore the ADRs related to DDIs between antihypertensive drugs and NSAIDs. Over the 11, 442 notifications of ADRs recorded in this database in patients treated with oral antihypertensive drugs between 2008 and 2010, 517 (4.5 and 95% CI: 4.1-4.9) also included exposure to NSAIDs. These subjects were more frequently women, took more drugs in general, and were younger and less frequently treated with antiplatelet drugs. In 24.2% of them (125 patients), a DDI between NSAIDs and antihypertensive drugs was potentially the cause of the reported ADR. Acute renal failure caused by DDIs between NSAIDs and angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), or diuretics was the most frequently reported ADR (20.7%). Finally, in the French Pharmacovigilance database, around one-fourth of associations NSAIDs  +  antihypertensive drugs are associated with a 'serious' ADR (mainly acute renal failure), suggesting that this well-known DDI is not enough taken into account by prescribers.

  12. French Antilles and Guiana.

    PubMed

    1983-11-01

    This discussion of French Antilles and Guiana cover the following: the people, geography, history, government, political conditions, economy, and relations with the US. In 1983 the population totaled 303,000 with an annual growth rate of 0.09%. The infant mortality rate (1981) was 12.6/1000 and life expectancy 68 years. About 98% of the people of Martinique are of Afro European or Afro European Indian descent. The remainder are the old planter families and a sizable number of metropolitan French. Most of the work force are employed in agriculture or food processing and associated industries. Most permanent residents of Guadeloupe are of mixed Afro European descent. A few thousand Metropolitan French reside there. Most French Guianese live along the coast, about 1/2 of them in the capital. Martinique is the northernmost of the Windward Islands, which are part of the Lesser Antilles chain in the Caribbean Sea southeast of Puerto Rico. Guadeloupe comprises 2 of the Leeward Islands, which are also part of the Lesser Antilles chain. French Guiana is located on the northern coast of South America, a few degrees north of the Equator. Indians were the 1st known indigenous inhabitants of French Guiana and the French Antilles. Columbus sighted Guadeloupe in 1493, Martinique in 1493 or 1502, and the Guiana coast probably during his 3rd voyage in 1498. French Guiana, Guadeloupe, and Martinique, as overseas departments of France since 1946, are integral parts of the French Republic. Their relationship to Metropolitan France is somewhat similar to that of Alaska and Hawaii to the counterminous US. Each department has a general council composed of 1 representative elected by each canton. Guadeloupe and Martinique each elect 2 senators to the French Senate and 3 deputies to the National Assembly. French Guiana elects 1 senator and 1 deputy. In each of the 3 departments exist individuals and small political parties that advocate immediate independence, but their adherents form only

  13. The French Revolution and the French Language: A Paradox?

    ERIC Educational Resources Information Center

    Djite, Paulin

    1992-01-01

    Explores the relationship between revolutionary ideals and the subsequent expansion and promotion of the French language. It is shown, through a linguistic and sociopolitical history of the French Revolution and the French language, that there is no incompatibility between the two and that the movement of Francophonie is a continuation of France's…

  14. French for Marketing. Using French in Media and Communications.

    ERIC Educational Resources Information Center

    Batchelor, R. E.; Chebli-Saadi, M.

    The textbook, entirely in French, is designed to help prepare anglophone students for French language usage in the media and telecommunications. It is organized according to two major themes. The first part addresses the French of advertising; chapter topics include the actors in advertising (agencies, announcers, supports), forms of advertising,…

  15. Incidence of adverse events in antipsychotic-naïve children and adolescents treated with antipsychotic drugs: a French multicentre naturalistic study protocol (ETAPE)

    PubMed Central

    Menard, Marie-Line; Thümmler, Susanne; Giannitelli, Marianna; Olliac, Bertrand; Bonnot, Olivier; Cohen, David; Askenazy, Florence

    2016-01-01

    Introduction In France, over recent years, the prescription rate of antipsychotic (AP) remained stable in children and adolescents. Prescription of second-generation antipsychotics increased, whereas prescription of first-generation antipsychotics decreased. Off-label prescriptions are very frequent in this population. Adverse events (AEs) in youth treated with AP are common and may be severe. AEs have hitherto been poorly monitored in naturalistic studies independent from industry. Method and analysis We describe a French prospective multicentre study in an AP-naïve paediatric population named Etude de la Tolérance des AntiPsychotique chez l'Enfant (ETAPE). The study started in April 2013. So far, 200 patients have been included. The inclusion criteria are: male or female inpatients aged from 6 to 18 years, treated with an AP drug for less than 28 days, never been treated or having received AP for less than 3 months, discontinued at least 6 months prior to inclusion. These assessments of AE are performed at inclusion, as well as at 3, 6, 9 and 12 months after the introduction of the AP. The monitoring period will end in May 2016. Ethics and dissemination The study protocol was approved by the Ethics Committee ‘Sud Méditerrané V’ (number 12.082) and by the French National Agency for Medicines and Health Products Safety (number 2012-004546-15). All patients and their parents signed informed consent on enrolment in the study. We will submit the results of the study to relevant journals and offer national and international presentations. This study will enable better characterisation of the prescription of AP drugs. The results will further help to develop quality standards and recommendations for monitoring AE during the prescription of AP. Trial registration number NCT02007928. PMID:27053275

  16. [About the relationship between medicine and social sciences: the French Foundation for the Study of Human Problems or Carrel Foundation (1941-1945)].

    PubMed

    Drouard, A

    1994-01-01

    Nobel Prize winner for medicine in 1912, author of a widely acclaimed best seller which was published in English and in French in 1935, Man, the Unknown, Alexis Carrel was Regent of the French Foundation for the Study of Human Problems from 1942 to 1944, during the Second World War in France. The Foundation, known as the "Carrel Foundation", was created as a financially autonomous public establishment with full legal status and had a dual mission: to stkudy "all possible means of safeguarding, improving and developing the French population" (1) and to "synthesize efforts undertaken by its own members or by others and to develop the science of man" (2). Considering its short official existence and the exceptional circumstances of the period, the scientific work of the Foundation is impressive: the demographical analyses undertaken by R. Gessain, P. Tincent, and J. Bourgeois; the pioneer work of J. Sutter in nutrition; J. Merlet's work on group settings; the Gallup polls undertaken by J. Stoetzel's team; and the work and publications of the F. Perroux Department of Bio-Sociology, without failing to mention the study carried out on a group of one hundred thousand children. Amongst the effects of the Foundation, one must mention the National Institute of Demographic Studies (INED) and with it, the establishment of one of the most active and productive research groups in the Social and Human Sciences in France. There are other initiatives and activities which form part of the Foundation's inheritance: the creation in 1947 by Dr A. Gros, former Vice-regent of the Foundation, of the group of "Advisers in Synthesis"; the jkoint creation ten years later by D Gros and G. Berger of the group and the publication "Prospective"; the wide multidisciplinary study undertaken by the (DGRST) "Délégation Générale à la Recherche Scientifique et Technique" undertaken in 1960 thanks to the initiative of R. Gessain and of J. Sutter; and the Monaco Forums on Social Sciences, not to

  17. French nuclear physics accelerator opens

    NASA Astrophysics Data System (ADS)

    Dumé, Belle

    2016-12-01

    A new €140m particle accelerator for nuclear physics located at the French Large Heavy Ion National Accelerator (GANIL) in Caen was inaugurated last month in a ceremony attended by French president François Hollande.

  18. Patient-Reported Treatment Satisfaction with Rivaroxaban for Stroke Prevention in Atrial Fibrillation. A French Observational Study, the SAFARI Study

    PubMed Central

    Hanon, Olivier; Chaussade, Edouard; Gueranger, Pierre; Gruson, Elise; Bonan, Sabrina; Gay, Alain

    2016-01-01

    Background For antithrombotic treatments, Patient Reported Outcomes (PRO) and patient satisfaction with treatment are essential data for physicians because of the strong relationship between patient satisfaction and adherence to treatment. The impact of rivaroxaban on patient satisfaction and quality of life was not sufficiently documented in phase III studies. There is a need for further data in this field especially in real life conditions. Methods The SAFARI study is composed of patients with non-valvular atrial fibrillation (AF), previously treated with vitamin K antagonist (VKA) and switched to rivaroxaban. Patient satisfaction with anticoagulant therapy was measured by the Anti-Clot Treatment Scale (ACTS), a validated 15-item patient-reported scale including a 12-item ACTS Burdens scale and a 3-item ACTS Benefits scale. Satisfaction of medication was compared between baseline and 1, 3 and 6 months. Results Study population was composed of 405 patients. Mean age was 74.8 (standard deviation = 9.0) years and 63.0% were male. Mean CHA2DS2-VASc score was 3.4 (1.5) and mean HAS-BLED score was 2.9 (1.0). After 3 months of treatment with rivaroxaban, patient satisfaction improved compared with VKA: mean ACTS burdens scores significantly increased by 8.3 (8.9) points (p<0.0001) and ACTS benefits scale by 0.4 (2.9) (p<0.001). Compared with baseline, the improvement in ACTS burdens and benefits became apparent at 1 month (46.5 vs. 53.6 p<0.001 and 10.4 vs. 10.7, p<0.05 respectively) and persisted at 6 months (46.5 vs. 54.76 p<0.001 and 10.4 vs. 10.8 p = 0.02 respectively). Rivaroxaban persistence was 88.7% at 6 months. Conclusions SAFARI data support a good risk-benefit balance for rivaroxaban, with a good safety profile and encourage PRO design studies. The switch from VKA to rivaroxaban improved patient satisfaction at 1, 3 and 6 months after rivaroxaban initiation among patients with AF, particularly in reducing patient-reported anticoagulation burden. PMID:27935987

  19. Randomised, prospective, medico-economic nationwide French study of islet transplantation in patients with severely unstable type 1 diabetes: the STABILOT study protocol

    PubMed Central

    David-Tchouda, Sandra; Margier, Jennifer; Schir, Edith; Wojtusciszyn, Anne; Borot, Sophie; Kessler, Laurence; Morelon, Emmanuel; Thivolet, Charles; Pattou, François; Vantyghem, Marie Christine; Berney, Thierry; Benhamou, Pierre-Yves

    2017-01-01

    Introduction Islet transplantation may be an appropriate treatment option for patients with severely unstable type 1 diabetes experiencing major glucose variability with severe hypoglycaemia despite intensive insulin therapy. Few data are available on the costs associated with islet transplantation in relation to its benefits. The STABILOT study proposes to assess the economic impact of islet transplantation in comparison with the current best medical treatment defined as sensor-augmented pump (SAP) therapy. Methods The trial will adopt an open-label, randomised, multicentred design. The study will include 30 patients with severely unstable type 1 diabetes. Eligible participants will be 18–65 years old, with type 1 diabetes duration >5 years, a negative basal or stimulated C-peptide, and severe instability defined by persistent, recurrent and disabling severe hypoglycaemia, despite optimised medical treatment. Participants will be randomised into two groups: one group with immediate registration for islet transplantation, and one group with delayed registration for 1 year while patients receive SAP therapy. The primary endpoint will be the incremental cost-utility ratio at 1 year between islet transplantation and SAP therapy. Perspectives of both the French Health Insurance System and the hospitals will be retained. Ethics and dissemination Ethical approval has been obtained at all sites. The trial has been approved by ClinicalTrials.gov (Trial registration ID NCT02854696). All participants will sign a free and informed consent form before randomisation. Results of the study will be communicated during national and international meetings in the field of diabetes and transplantation. A publication will be sought in journals usually read by physicians involved in diabetes care, transplantation and internal medicine. Trial registration number NCT02854696; Pre-results. PMID:28219959

  20. America's Tolerance for French Radicalism

    ERIC Educational Resources Information Center

    Wolin, Richard

    2008-01-01

    The publication of Francois Cusset's "French Theory" raises a series of fascinating questions concerning the trans-Atlantic transmission and circulation of ideas. Most important, it impels everyone to inquire why for a time French thought managed to flourish in American universities while French intellectuals rapidly abandoned the entire…

  1. The Impact of Stressful Life Events on Excessive Alcohol Consumption in the French Population: Findings from the GAZEL Cohort Study

    PubMed Central

    Tamers, Sara L.; Okechukwu, Cassandra; Bohl, Alex A.; Guéguen, Alice; Goldberg, Marcel; Zins, Marie

    2014-01-01

    Background Major life changes may play a causative role in health through lifestyle factors, such as alcohol. The objective was to examine the impact of stressful life events on heavy alcohol consumption among French adults. Methods Trajectories of excessive alcohol consumption in 20,625 employees of the French national gas and electricity company for up to 5 years before and 5 years after an event, with annual measurements from 1992. We used repeated measures analysis of time series data indexed to events, employing generalized estimating equations. Results For women, excessive alcohol use increased before important purchase (p = 0.021), children leaving home (p<0.001), and death of loved ones (p = 0.03), and decreased before widowhood (p = 0.015); in the year straddling the event, increased consumption was observed for important purchase (p = 0.018) and retirement (p = 0.002); at the time of the event, consumption decreased for marriage (p = 0.002), divorce, widowhood, and death of loved one (all p<0.001), and increased for retirement (p = 0.035). For men, heavy alcohol consumption increased in the years up to and surrounding the death of loved ones, retirement, and important purchase (all p<0.001), and decreased after (all p<0.001, except death of loved one: p = 0.006); at the time of the event, consumption decreased for all events except for children leaving home and retirement, where we observed an increase (all p<0.001). For women and men, heavy alcohol consumption decreased prior to marriage and divorce and increased after (all p<0.001, except for women and marriage: p = 0.01). Conclusion Stressful life events promote healthy and unhealthy alcohol consumption. Certain events impact alcohol intake temporarily while others have longer-term implications. Research should disentangle women's and men's distinct perceptions of events over time. PMID:24475318

  2. Teaching the French Revolution.

    ERIC Educational Resources Information Center

    Adams, Thomas M.

    1989-01-01

    Reports on presentations made at a symposium sponsored by the Connecticut Humanities Council. Papers dealt with teaching the French Revolution by presenting European history in new relationships with the rest of the world and by examining the Declaration of the Rights of Man as it related to the role of women. (KO)

  3. The French Revolution.

    ERIC Educational Resources Information Center

    Scrofani, E. Robert; Johnston, Anne

    This 10-day unit on the French Revolution is designed to help high school students understand the interplay of economic, social, and political forces in the process of revolutionary change, and the development of modern democratic forms of government. Critical thinking and geographic skill activities are employed throughout the unit and include…

  4. I Can Speak French.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The guide presents content and techniques for teaching conversational French in the elementary grades. It contains an introductory section and 20 units for classroom instruction. The introduction includes notes on the overall objectives of the course, general guidelines on classroom procedure, and specific techniques for use of the materials…

  5. Know Your Laws. French.

    ERIC Educational Resources Information Center

    Watson, Joan Q.; Ledun, Andree

    This French language version of "Know Your Laws" consists of 24 self-contained modules designed to acquaint the Florida adult student with laws she/he will meet in everyday life; fundamentals of local, state, and federal governments; and the criminal and juvenile justice systems. (The 130 objectives are categorized in the first three…

  6. French Theory's American Adventures

    ERIC Educational Resources Information Center

    Cusset, Francois

    2008-01-01

    In this article, the author discusses how it is simply too late to be still speaking about French theory and its role in the intellectual life of the United States today. It seems to many observers that the gap between real-life politics and theory's guerrillas is much too wide already, after 30 years of academic fever, for the two worlds to even…

  7. French 3200, Course Description.

    ERIC Educational Resources Information Center

    Newfoundland and Labrador Dept. of Education, St. John's. Div. of Instruction.

    The objectives and course content for French 3200, a secondary level course intended for the second or third year of four- and six-credit language course sequences in Newfoundland high schools, are outlined. Its primary objectives relate to the skill development in the four language skill areas (listening, speaking, reading, and writing),…

  8. Technoscientific French for Teachers.

    ERIC Educational Resources Information Center

    Muller, Brigitte D.

    A two-semester sequence of courses in French and Spanish for science and technology at Eastern Michigan University responds to alumni demands for better linguistic and cultural preparation for increasingly global business and industry. In addition, high schools teacher enrolled in the courses find they answer a need for professional upgrading of…

  9. Living in Ontario French

    ERIC Educational Resources Information Center

    Nadasdi, Terry

    2005-01-01

    This article presents a variationist analysis of verbs meaning "reside" in Ontario French. Four lexical variants are examined: "demeurer," "habiter," "rester" and "vivre." Results reveal that "rester" is used most often by unrestricted speakers and least often by those whose use of French…

  10. Changes in the Quality of Paper in French Books, 1860-1914: A Study of Selected Holdings of the Wilson Library, University of North Carolina.

    ERIC Educational Resources Information Center

    Rutledge, John; Owen, Willy

    1983-01-01

    This survey of paper quality of French-language holdings in history and literature (1860-1914) at Wilson Library reveals that a serious decline in paper quality in French books began around 1885 and continued through the rest of the period. Data on specific publishers and 14 references are included. (EJS)

  11. An Exploratory Study on the Role of L1 Chinese and L2 English in the Cross-Linguistic Influence in L3 French

    ERIC Educational Resources Information Center

    Cai, Hansong; Cai, Luna Jing

    2015-01-01

    This research investigates cross-linguistic influence in the comprehension of L3 French past tense. A close examination was made on the L1 (Chinese) and L2 (English) transfer patterns among 20 English majors in their early acquisition of L3 French passé compose (PC). Data were collected through introspective think-aloud protocol in a comprehension…

  12. Association of screen time with self-perceived attention problems and hyperactivity levels in French students: a cross-sectional study

    PubMed Central

    Guichard, Elie; Kurth, Tobias

    2016-01-01

    Objective To investigate whether high levels of screen time exposure are associated with self-perceived levels of attention problems and hyperactivity in higher education students. Design Cross-sectional study among participants of the i-Share cohort. Setting French-speaking students of universities and higher education institutions. Participants 4816 graduate students who were at least 18 years old. Exposure Screen time was assessed by self-report of the average time spent on five different screen activities on smartphone, television, computer and tablet and categorised into quartiles. Main outcome measure We used the Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS-v1.1) concerning students’ behaviour over the past 6 months to measure self-perceived levels of attention problems and hyperactivity. Responses were summarised into a global score as well as scores for attention problems and hyperactivity. Results The 4816 participants of this study had a mean age of 20.8 years and 75.5% were female. Multivariable ordinary regression models showed significant associations of screen time exposure with quintiles of the total score of self-perceived attention problems and hyperactivity levels as well as the individual domains. Compared to the lowest screen time exposure category, the ORs (95% CI) were 1.58 (1.37 to 1.82) for each increasing level of quintiles of the global score, 1.57 (1.36 to 1.81) for increasing quintiles of attention levels and 1.25 (1.09 to 1.44) for increasing quartiles of hyperactivity. Conclusions Results of this large cross-sectional study among French university and higher education students show dose-dependent associations between screen time and self-perceived levels of attention problems and hyperactivity. Further studies are warranted to evaluate whether interventions could positively influence these associations. PMID:26920440

  13. "-age" dans le systeme suffixal du francais quebecois ("-age" in the Suffix System of Quebec French). Montreal Working Papers in Linguistics, Vol. 4.

    ERIC Educational Resources Information Center

    Pupier, Paul; And Others

    This study relates the suffix "-age" to "-able,""-eux,""-ment,""-Xtion," and "-ure" in Quebec French. Morphologically, some "-age" suffixals which can be denominal in Quebec French can only be deverbal in European French. Semantically, "-age" deverbals are subdivided…

  14. A preliminary study of viral metagenomics of French bat species in contact with humans: identification of new mammalian viruses.

    PubMed

    Dacheux, Laurent; Cervantes-Gonzalez, Minerva; Guigon, Ghislaine; Thiberge, Jean-Michel; Vandenbogaert, Mathias; Maufrais, Corinne; Caro, Valérie; Bourhy, Hervé

    2014-01-01

    The prediction of viral zoonosis epidemics has become a major public health issue. A profound understanding of the viral population in key animal species acting as reservoirs represents an important step towards this goal. Bats harbor diverse viruses, some of which are of particular interest because they cause severe human diseases. However, little is known about the diversity of the global population of viruses found in bats (virome). We determined the viral diversity of five different French insectivorous bat species (nine specimens in total) in close contact with humans. Sequence-independent amplification, high-throughput sequencing with Illumina technology and a dedicated bioinformatics analysis pipeline were used on pooled tissues (brain, liver and lungs). Comparisons of the sequences of contigs and unassembled reads provided a global taxonomic distribution of virus-related sequences for each sample, highlighting differences both within and between bat species. Many viral families were present in these viromes, including viruses known to infect bacteria, plants/fungi, insects or vertebrates, the most relevant being those infecting mammals (Retroviridae, Herpesviridae, Bunyaviridae, Poxviridae, Flaviviridae, Reoviridae, Bornaviridae, Picobirnaviridae). In particular, we detected several new mammalian viruses, including rotaviruses, gammaretroviruses, bornaviruses and bunyaviruses with the identification of the first bat nairovirus. These observations demonstrate that bats naturally harbor viruses from many different families, most of which infect mammals. They may therefore constitute a major reservoir of viral diversity that should be analyzed carefully, to determine the role played by bats in the spread of zoonotic viral infections.

  15. Factors associated with early menarche: results from the French Health Behaviour in School-aged Children (HBSC) study

    PubMed Central

    2010-01-01

    Background Puberty is a transition period making physiological development a challenge adolescents have to face. Early pubertal development could be associated with higher risks of poor health. Our objective was to examine risk behaviours, physical and psychological determinants associated with early menarche (<11 years). Methods Early menarche was assessed in the Health Behaviour in School-aged Children French cross-sectional survey. Data were collected in 2006 by anonymous self-reported standardized questionnaire from a nationally representative sample of 1072 15 years old girls in school classrooms. Family environment, school experience, physical and psychological factors, risk behaviours (substance use and sexual initiation) were recorded. Logistic regression models were applied (analysing for crude and adjusted relationships between early menarche and risk behaviours controlled for family context). Results Median age at menarche was 13.0 years; 57 girls (5.3%) were early-matured. Controlled for familial environment, early menarche was associated with having had more than two life-drunkenness episodes (adjusted OR = 2.5 [1.3-4.6]), early sexual initiation (adjusted OR = 2.8 [1.3-6.0]) and overweight (adjusted OR = 7.3 [3.6-14.9]). Conclusion Early-maturing girls may affiliate with older adolescents, hence engage in risk behaviours linked to their appearance rather than their maturity level. Factors associated with early menarche highlight the need to focus attention on early-matured girls to prevent further health problems linked to risk behaviours. PMID:20353570

  16. A Preliminary Study of Viral Metagenomics of French Bat Species in Contact with Humans: Identification of New Mammalian Viruses

    PubMed Central

    Dacheux, Laurent; Cervantes-Gonzalez, Minerva; Guigon, Ghislaine; Thiberge, Jean-Michel; Vandenbogaert, Mathias; Maufrais, Corinne

    2014-01-01

    The prediction of viral zoonosis epidemics has become a major public health issue. A profound understanding of the viral population in key animal species acting as reservoirs represents an important step towards this goal. Bats harbor diverse viruses, some of which are of particular interest because they cause severe human diseases. However, little is known about the diversity of the global population of viruses found in bats (virome). We determined the viral diversity of five different French insectivorous bat species (nine specimens in total) in close contact with humans. Sequence-independent amplification, high-throughput sequencing with Illumina technology and a dedicated bioinformatics analysis pipeline were used on pooled tissues (brain, liver and lungs). Comparisons of the sequences of contigs and unassembled reads provided a global taxonomic distribution of virus-related sequences for each sample, highlighting differences both within and between bat species. Many viral families were present in these viromes, including viruses known to infect bacteria, plants/fungi, insects or vertebrates, the most relevant being those infecting mammals (Retroviridae, Herpesviridae, Bunyaviridae, Poxviridae, Flaviviridae, Reoviridae, Bornaviridae, Picobirnaviridae). In particular, we detected several new mammalian viruses, including rotaviruses, gammaretroviruses, bornaviruses and bunyaviruses with the identification of the first bat nairovirus. These observations demonstrate that bats naturally harbor viruses from many different families, most of which infect mammals. They may therefore constitute a major reservoir of viral diversity that should be analyzed carefully, to determine the role played by bats in the spread of zoonotic viral infections. PMID:24489870

  17. [Optimizing good use and costs of anticancer drugs: A French inter regional study of the Observatory of Cancer].

    PubMed

    Grudé, Françoise; Bessard, Réjane; Bourgeois, Hugues; Douillard, Jean-Yves; Gamelin, Erik; Metges, Jean-Philippe; Riché, Christian; Vidal, Anne-Marie

    2013-03-01

    Optimizing the care management of patients is a major issue for our society. In Brittany-Pays-de-la-Loire (almost 10% of French population), an observatory of cancer has been created in 2003. Its main objective was the follow-up of expensive drugs. The knowledge of the use of these drugs in clinical practice has led to development of a thesaurus of good use. Thus, regular exchanges between clinicians have almost totally reduced not medically justified prescriptions by the thesaurus after and before administration to patient. The thesaurus has given away to national guidelines from 2007. For example, in these two regions, optimization of the use of gemcitabine and bevacizumab has allowed to save respectively 2.5 millions euros between 2005 and 2008 and 3 millions euros between 2009 and 2010 (breast cancer only). Optimizing the use of anticancer drugs has allowed a real health economy without any bad impact on patient management. Respecting medical ethics, the main objective remains to optimize health care. This highly participation of clinicians currently allows to reflect together on the relevance of the last chemotherapy.

  18. The issue of delivery room infections in the Italian law. A brief comparative study with English and French jurisprudence.

    PubMed

    Zaami, Simona; Montanari Vergallo, Gianluca; Napoletano, Simona; Signore, Fabrizio; Marinelli, Enrico

    2017-01-31

    Delivery room infections are frequent, and many of them could be avoided through higher standards of care. The authors examine this issue by comparing it to English and French reality. Unlike England, in Italy and France the relationship established between health facility, physician and patient is outlined in a contract. In England, the judges' decisions converge toward a better and higher protection of the patient-the actor-and facilitate the probative task. In case of infections, including those occurring in the delivery room, three issues are evaluated: the hospital's negligent conduct, damages if any and causal nexus. Therefore, the hospital must demonstrate to have taken the appropriate asepsis measures according to current scientific knowledge concerning not only treatment, but also diagnosis, previous activities, surgery and post-surgery. In order to avoid a negative sentence, both physicians and hospital have to demonstrate their correct behavior and that the infection was caused by an unforeseeable event. The authors examine the most significant rulings by the Courts and the Supreme Court. They show that hospitals can avoid being accused of negligence and recklessness only if they can demonstrate to have implemented all the preventive measures provided for in the guidelines or protocols.

  19. Sanctification of "the accursed". Drinking habits of the French existentialists in the 1940s (a case study).

    PubMed

    Arppe, T

    1998-01-01

    The chapter deals with the drinking habits of the French existentialists during and after World War II (roughly from 1943 to 1948). It attempts to show that the phenomenon cannot be understood separately from their lifestyle as a whole, which in this case (as I claim) is primarily manifested through a certain (mythical) structure of meanings related to the category of the sacred. Jean-Paul Sartre's position as the leading intellectual figure of the time is also to be seen as a result of his ambiguous reputation as a "prophet" and a "criminal" in the yellow press. What is involved is a single mythical structure, where "decadent" life is precisely one aspect of sanctification. On the other hand, Sartre's "bohemian lifestyle" and his desire to break bourgeois habits can be seen as a variant of the bourgeois myth of the artistic lifestyle created in the 19th century. From this angle, existentialism can in a certain sense be considered the last hybrid expression of the "transgressive" myth of rebellion which this sort of lifestyle had crystallized.

  20. Estimating drinking-water ingestion and dermal contact with water in a French population of pregnant women: the EDDS cohort study.

    PubMed

    Albouy-Llaty, Marion; Dupuis, Antoine; Grignon, Claire; Strezlec, Sylvie; Pierre, Fabrice; Rabouan, Sylvie; Migeot, Virginie

    2015-05-01

    The aim of the present study, a part of the Endocrine Disruptor Deux-Sèvres (EDDS) cohort study, was to estimate water-use habits of pregnant French women. The study population consisted of 132 pregnant women living in Deux-Sèvres (France) in 2012-2013, in areas where drinking water is exclusively produced by surface water. Drinking-water data included ingested water (tap, bottled and filtered) and ingestion place (home, work and elsewhere). Dermal contact with water included showering, bathing, swimming, spa use, hand-washing and other water activities. Data were collected through face-to-face interviews at second and third trimesters of pregnancy with a 1-day-recall questionnaire. Intertrimestral differences in water-use habits were assessed. Predictors of water ingestion and duration of dermal contact with water were assessed with multiple linear regressions. At the second trimester of pregnancy, the mean total drinking-water ingestion was 1.8±0.6 l per day (mean and SD), 71% of which was tap water. Total drinking-water ingestion was not different between both trimesters but ingestion place differed. Dermal contact with water estimate was 188±118 and 173±92 min/week at second and third trimesters, respectively. Smoking increased water ingestion 777 ml/day 95% CI (171-1384). Duration of dermal contact in spring was 30 min/week 95% CI (13-48) higher than in winter. Obese women spend 26 min/week 95% CI (2-50) more showering than women with recommended weight. Our estimates of pregnant French women's exposure to water will help researchers to better assess water pollutant risks.

  1. Exploratory study toward development of the French version of the questionnaire on personality traits (QPT/VKP-4) in an elderly population in comparison to young adults.

    PubMed

    Courtois, R; Enfoux, A; Plaisant, O; Coutard, N; Duijsens, I J; Réveillère, C; Camus, V; El-Hage, W

    2014-08-01

    This research is an exploratory study toward development of the French version of the Questionnaire on Personality Traits (QPT/VKP-4). The goal was to assess its association with the Big Five Inventory (BIG-5) and to explore the personality characteristics of the elderly compared to young adults. The 241 participants included 83 elderly people and 158 young adults. Borderline and anxious personality disorders were less frequent in elderly women than in young women, and depressive personality disorder was less frequent in elderly men. Dimension scores were higher for Conscientiousness in the elderly, Agreeableness in elderly women, and Extraversion in elderly men. Statistically significant correlations were found between personality dimension scores using the VKP-4 and the BIG-5.

  2. Building a Writing Community through Learning of French

    ERIC Educational Resources Information Center

    Bissoonauth-Bedford, Anu.; Stace, Ray

    2015-01-01

    This paper reports on a pilot study designed to develop writing proficiency in French via collaborative writing activities at intermediate level at the University of Wollongong in Australia. Twenty four students in the final year of French studies program took part in this innovative approach which integrates multimodal functionality of the…

  3. Current developments in French ethnopsychoanalysis.

    PubMed

    Sturm, Gesine; Nadig, Maya; Moro, Marie Rose

    2011-07-01

    French ethnopsychoanalytic approaches to therapy with immigrants combine the psychoanalytical interest in subjectivity with a specific concern for cultural factors and with the role migration plays as a crucial life event. Recent approaches consider culture as profoundly hybrid and use the notions of ''métissage'' and ''décentrage'' as central concepts. This article presents extracts from a qualitative study of ethnopsychoanalytic therapies with immigrant families. The authors argue that the ethnopsychoanalytic approach helps to open new ways of considering cultural hybridity and create a third space where experiences ''from the margins'' may be verbalized.

  4. Acquisition of the Internal and External Constraints of Variable Schwa Deletion by French Immersion Students

    ERIC Educational Resources Information Center

    Uritescu, Dorin; Mougeon, Raymond; Rehner, Katherine; Nadasdi, Terry

    2004-01-01

    This article is one among a series of studies on the acquisition of patterns of linguistic variation observable in the speech of native speakers of Canadian French by French immersion (FI) students. The present study is centered on deletion of the central vowel schwa, a widespread feature of casual spoken French. In this study, FI students are…

  5. Toxoplasma Seroconversion with Negative or Transient Immunoglobulin M in Pregnant Women: Myth or Reality? A French Multicenter Retrospective Study

    PubMed Central

    Cimon, B.; Chemla, C.; Darde, M. L.; Delhaes, L.; L'Ollivier, C.; Godineau, N.; Houze, S.; Paris, L.; Quinio, D.; Robert-Gangneux, F.; Villard, O.; Villena, I.; Candolfi, E.; Pelloux, H.

    2013-01-01

    Classically, Toxoplasma infection is associated with high levels of specific IgM antibody and a rise in specific IgG levels 1 to 3 weeks later. Atypical IgG seroconversion, without IgM detection or with transient IgM levels, has been described during serologic follow-up of seronegative pregnant women and raises difficulties in interpreting the results. To evaluate the frequency and the characteristics of these atypical cases of seroconversion, an investigation was conducted within the French National Reference Center for Toxoplasmosis, from which 26 cases collected from 12 laboratories belonging to the network were identified. The aim of this work was to retrospectively analyze the results of serologic testing, the treatments administered, and the results of prenatal and postnatal follow-up for these women. In each case, IgG antibodies were detected using both screening and confirmatory tests. IgM antibodies were not detected in 15 cases, and the levels were equivocal or low-positive in 11 cases. The IgG avidity results were low in 16 cases and high in one case. Most of the pregnant women (22/26) were treated with spiramycin from the time that IgG antibodies appeared until delivery. Amniotic fluid was analyzed for Toxoplasma gondii DNA by PCR in 11/26 cases, and the results were negative in all cases. Congenital toxoplasmosis was ruled out in 12/26 newborns. There was no abnormality observed at birth for 10 newborns and no information available for 4 newborns. In conclusion, when the interpretation of serological results is so difficult, it seems cautious to initiate treatment by spiramycin and to follow the pregnant women and their newborns. PMID:23616461

  6. Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case–Control Study in Guadeloupe (French West Indies)

    PubMed Central

    Emeville, Elise; Giusti, Arnaud; Coumoul, Xavier; Thomé, Jean-Pierre; Blanchet, Pascal

    2014-01-01

    Background: Long-term exposure to persistent pollutants with hormonal properties (endocrine-disrupting chemicals; EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited. Objectives: We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p´-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin-like polychlorinated biphenyl congener 153 (PCB-153). Methods: We evaluated 576 men with newly diagnosed PCa (before treatment) and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case–control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation. Results: We estimated a significant positive association between DDE and PCa [adjusted odds ratio (OR) = 1.53; 95% CI: 1.02, 2.30 for the highest vs. lowest quintile of exposure; ptrend = 0.01]. PCB-153 was inversely associated with PCa (OR = 0.30; 95% CI: 0.19, 0.47 for the highest vs. lowest quintile of exposure values; ptrend < 0.001). Also, PCB-153 was more strongly associated with low-grade than with high-grade PCa. Conclusions: Associations of PCa with DDE and PCB-153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs; and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health. Citation: Emeville E, Giusti A, Coumoul X, Thomé JP, Blanchet P, Multigner L. 2015. Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case–control study in Guadeloupe (French West Indies). Environ Health Perspect 123:317–323; http://dx.doi.org/10.1289/ehp.1408407 PMID:25493337

  7. Reading Comprehension in a Large Cohort of French First Graders from Low Socio-Economic Status Families: A 7-Month Longitudinal Study

    PubMed Central

    Gentaz, Edouard; Sprenger-Charolles, Liliane; Theurel, Anne; Colé, Pascale

    2013-01-01

    Background The literature suggests that a complex relationship exists between the three main skills involved in reading comprehension (decoding, listening comprehension and vocabulary) and that this relationship depends on at least three other factors orthographic transparency, children’s grade level and socioeconomic status (SES). This study investigated the relative contribution of the predictors of reading comprehension in a longitudinal design (from beginning to end of the first grade) in 394 French children from low SES families. Methodology/Principal findings Reading comprehension was measured at the end of the first grade using two tasks one with short utterances and one with a medium length narrative text. Accuracy in listening comprehension and vocabulary, and fluency of decoding skills, were measured at the beginning and end of the first grade. Accuracy in decoding skills was measured only at the beginning. Regression analyses showed that listening comprehension and decoding skills (accuracy and fluency) always significantly predicted reading comprehension. The contribution of decoding was greater when reading comprehension was assessed via the task using short utterances. Between the two assessments, the contribution of vocabulary, and of decoding skills especially, increased, while that of listening comprehension remained unchanged. Conclusion/Significance These results challenge the ‘simple view of reading’. They also have educational implications, since they show that it is possible to assess decoding and reading comprehension very early on in an orthography (i.e., French), which is less deep than the English one even in low SES children. These assessments, associated with those of listening comprehension and vocabulary, may allow early identification of children at risk for reading difficulty, and to set up early remedial training, which is the most effective, for them. PMID:24250802

  8. Dealing with missing data in the Center for Epidemiologic Studies Depression self-report scale: a study based on the French E3N cohort

    PubMed Central

    2013-01-01

    Background The Center for Epidemiologic Studies - Depression scale (CES-D) is a validated tool commonly used to screen depressive symptoms. As with any self-administered questionnaire, missing data are frequently observed and can strongly bias any inference. The objective of this study was to investigate the best approach for handling missing data in the CES-D scale. Methods Among the 71,412 women from the French E3N prospective cohort (Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale) who returned the questionnaire comprising the CES-D scale in 2005, 45% had missing values in the scale. The reasons for failure to complete certain items were investigated by semi-directive interviews on a random sample of 204 participants. The prevalence of high depressive symptoms (score ≥16, hDS) was estimated after applying various methods for ignorable missing data including multiple imputation using imputation models with CES-D items with or without covariates. The accuracy of imputation models was investigated. Various scenarios of nonignorable missing data mechanisms were investigated by a sensitivity analysis based on the mixture modelling approach. Results The interviews showed that participants were not reluctant to answer the CES-D scale. Possible reasons for nonresponse were identified. The prevalence of hDS among complete responders was 26.1%. After multiple imputation, the prevalence was 28.6%, 29.8% and 31.7% for women presenting up to 4, 10 and 20 missing values, respectively. The estimates were robust to the various imputation models investigated and to the scenarios of nonignorable missing data. Conclusions The CES-D scale can easily be used in large cohorts even in the presence of missing data. Based on the results from both a qualitative study and a sensitivity analysis under various scenarios of missing data mechanism in a population of women, missing data mechanism does not appear to be nonignorable and estimates

  9. The Role of Texture in French Spectral Music

    ERIC Educational Resources Information Center

    Besharse, Kari E.

    2009-01-01

    This study examines the essential role of texture in French spectral music and its contribution to musical evolution and form in specific works by Gerard Grisey, Tristan Murail, Philippe Hurel, and Kaija Saariaho. The use of texture in French spectral music is placed in a historical context by exploring the new ways that texture is employed in…

  10. Visuo-Orthographic Knowledge in Deaf Readers of French

    ERIC Educational Resources Information Center

    Daigle, Daniel; Armand, Francoise; Demont, Elisabeth; Gombert, Jean-Emile

    2009-01-01

    This study investigated visuo-orthographic knowledge in deaf readers of French compared to age-matched hearing subjects. More specifically, we were interested in knowledge related to the legal position of double consonants and to the fact that double consonants are much more frequent than double vowels in written French. We used a word-likeness…

  11. Multilingualism and Web Advertising: Addressing French-Speaking Consumers

    ERIC Educational Resources Information Center

    Martin, Elizabeth

    2011-01-01

    Drawing inferences from both quantitative and qualitative data, this study examines the extent to which American companies tailor their Web advertising for global audiences with a particular focus on French-speaking consumers in North America, Europe, Africa, the Caribbean and French Polynesia. Explored from a sociolinguistic and social semiotic…

  12. Structural Influences on Initial Accent Placement in French

    ERIC Educational Resources Information Center

    Astesano, Corine; Bard, Ellen Gurman; Turk, Alice

    2007-01-01

    In addition to the phrase-final accent (FA), the French phonological system includes a phonetically distinct Initial Accent (IA). The present study tested two proposals: that IA marks the onset of phonological phrases, and that it has an independent rhythmic function. Eight adult native speakers of French were instructed to read syntactically…

  13. Facebook-Induced Motivation Shifts in a French Online Course

    ERIC Educational Resources Information Center

    Aubry, James

    2013-01-01

    This study explores the effects of instructor's self-disclosure using the Facebook social networking online platform on students' motivation types in an online language course. The participants were 104 beginning French students enrolled in an online French course at a major research university in the southeast U.S. The participants were divided…

  14. Do 11-Month-Old French Infants Process Articles?

    ERIC Educational Resources Information Center

    Halle, Pierre A.; Durand, Catherine; de Boysson-Bardies, Benedicte

    2008-01-01

    The first part of this study examined (Parisian) French-learning 11-month-old infants' recognition of the six definite and indefinite French articles: "le", "la", "les", "un", "une", and "des". The six articles were compared with pseudoarticles in the context of disyllabic or monosyllabic…

  15. Seismic and mechanical studies of the artificially triggered rockfall at Mount Néron (French Alps, December 2011)

    NASA Astrophysics Data System (ADS)

    Bottelin, P.; Jongmans, D.; Daudon, D.; Mathy, A.; Helmstetter, A.; Bonilla-Sierra, V.; Cadet, H.; Amitrano, D.; Richefeu, V.; Lorier, L.; Baillet, L.; Villard, P.; Donzé, F.

    2014-12-01

    The eastern limestone cliff of Mount Néron (French Alps) was the theater for two medium-size rockfalls between summer and winter 2011. On 14 August 2011, a ~2000 m3 rock compartment detached from the cliff, fell 100 m below and propagated down the slope. Although most of the fallen rocks deposited on the upper part of the slope, some blocks of about 15 m in size were stopped by a ditch and an earthen barrier after a run-out of 800 m. An unstable overhanging ~2600 m3 compartment remained attached to the cliff and was blasted on 13 December 2011. During this artificially triggered event, 7 blocks reached the same ditch, with volumes ranging from 0.8 to 12 m3. A semi-permanent seismic array located about 2.5 km from the site recorded the two events, providing a unique opportunity to understand and to compare the seismic phases generated during natural and artificially triggered rockfalls. Both events have signal duration of ~100 s with comparable maximum amplitudes recorded at large distances (computed local magnitude of 1.14 and 1.05, respectively), most of the energy lying below 20 Hz. Remote sensing techniques (photogrammetry and lidar) were employed before and after the provoked rockfall, allowing the volume and fracturing to be characterized. This event was filmed by two video cameras, and the generated ground motions were recorded using two temporary 3C seismic sensors and three seismic arrays deployed at the slope toe. Videos and seismogram processing provided estimates of the propagation velocity during the successive rockfall phases, which ranges from 12 to 30 m s-1. The main seismic phases were obtained from combined video and seismic signal analyses. The two most energetic phases are related to the ground impact of fallen material after free fall, and to individual rock block impacts into the ditch and the earthen barrier. These two phases are characterized by similar low-frequency content but show very different particle motions. The discrete element

  16. Seismic and mechanical studies of the artificially triggered rockfall at the Mount Néron (French Alps, December 2011)

    NASA Astrophysics Data System (ADS)

    Bottelin, P.; Jongmans, D.; Daudon, D.; Mathy, A.; Helmstetter, A.; Bonilla-Sierra, V.; Cadet, H.; Amitrano, D.; Richefeu, V.; Lorier, L.; Baillet, L.; Villard, P.; Donzé, F.

    2014-02-01

    The eastern limestone cliff of Mount Néron (French Alps) was the theatre of two medium-size rockfalls between summer and winter 2011. On 14 August 2011, a ~ 2000 m3 rock compartment detached from the cliff, fell 100 m below and propagated down the slope. Although most of the fallen rocks deposited in the upper part of the slope, about 15 meter-size blocks were stopped by a ditch and an earthen barrier after a runout of 800 m. An unstable overhanging ~ 2600 m3 compartment remained attached to the cliff and was blasted on 13 December 2011. During this artificially triggered event, 7 blocks reached the same ditch, with volumes ranging from 0.8 to 12 m3. A semi-permanent seismic array located about 2.5 km from the site recorded the two events, providing a unique opportunity to understand and to compare the seismic phases generated during natural and artificially triggered rockfalls. Both events have signal duration of ~ 100 s with comparable maximum amplitudes recorded at large distances (computed local magnitude of 1.14 and 1.05, respectively), most of the energy lying below 20 Hz. Remote sensing techniques (photogrammetry and LiDAR) were employed before and after the provoked rockfall, allowing the volume and fracturing to be characterized. This event was filmed by two video cameras and the generated ground motions were recorded using two temporary 3C seismic sensors and 3 seismic arrays deployed at the slope toe. Movie and seismogram processing provided estimates of the propagation velocity during the successive rockfall phases, which ranges from 12 m s-1 to 30 m s-1. The main seismic phases were obtained from combined video and seismic signal analyses. The two most energetic phases are related to the ground impact of fallen material after free-fall, and to individual rock block impacts into the ditch and the earthen barrier. These two phases are characterized by similar low-frequency content but show very different particle motions. The discrete element technique

  17. Using Conventional Sequences in L2 French

    ERIC Educational Resources Information Center

    Forsberg, Fanny

    2010-01-01

    By means of a phraseological identification method, this study provides a general description of the use of conventional sequences (CSs) in interviews at four different levels of spoken L2 French as well as in interviews with native speakers. Use of conventional sequences is studied with regard to overall quantity, category distribution and type…

  18. French perspectives on psychiatric classification.

    PubMed

    Crocq, Marc-Antoine

    2015-03-01

    This article reviews the role of the French schools in the development of psychiatric nosology. Boissier de Sauvages published the first French treatise on medical nosology in 1763. Until the 1880s, French schools held a pre-eminent position in the development of psychiatric concepts. From the 1880s until World War I, German-speaking schools exerted the most influence, featuring the work of major figures such as Emil Kraepelin and Eugen Bleuler. French schools were probably hampered by excessive administrative and cultural centralization. Between the 1880s and the 1930s, French schools developed diagnostic categories that set them apart from international classifications. The main examples are Bouffée Délirante, and the complex set of chronic delusional psychoses (CDPs), including chronic hallucinatory psychosis. CDPs were distinguished from schizophrenia by the lack of cognitive deterioration during evolution. Modern French psychiatry is now coming into line with international classification, such as DSM-5 and the upcoming ICD-11.

  19. Aerodynamic characteristics of French consonants

    NASA Astrophysics Data System (ADS)

    Demolin, Didier; Hassid, Sergio; Soquet, Alain

    2004-05-01

    This paper reports some aerodynamic measurements made on French consonants with a group of ten speakers. Speakers were recorded while saying nonsense words in phrases such as papa, dis papa encore. The nonsense words in the study combined each of the French consonants with three vowels /i, a, u/ to from two syllables words with the first syllable being the same as the second. In addition to the audio signal, recordings were made of the oral airflow, the pressure of the air in the pharynx above the vocal folds and the pressure of the air in the trachea just below the vocal folds. The pharyngeal pressure was recorded via a catheter (i.d. 5 mm) passed through the nose so that its open end could be seen in the pharynx below the uvula. The subglottal pressure was recorded via a tracheal puncture between the first and the second rings of the trachea or between the cricoid cartilage and the first tracheal ring. Results compare subglottal presssure, pharyngeal pressure, and airflow values. Comparisons are made between values obtained with male and female subjects and various types of consonants (voiced versus voiceless at the same place of articulation, stops, fricatives, and nasals).

  20. Syntax and Discourse in Near-Native French: Clefts and Focus

    ERIC Educational Resources Information Center

    Donaldson, Bryan

    2012-01-01

    This study examines aspects of the syntax-discourse interface in near-native French. Two cleft structures--"c'est" clefts and "avoir" clefts--are examined in experimental and spontaneous conversational data from 10 adult Anglophone learners of French and ten native speakers of French. "C'est" clefts mark focus, and…

  1. Acquisition of Complement Clitics and Tense Morphology in Internationally Adopted Children Acquiring French

    ERIC Educational Resources Information Center

    Gauthier, K.; Genesee, F.; Kasparian, K.

    2012-01-01

    The present study examined the language development of children adopted from China to examine possible early age effects with respect to their use of complement clitics, lexical diversity and verb morphology. We focused on these aspects of French because they distinguish second language learners of French and native French-speaking children with…

  2. Native and Nonnative Interpretation of Pronominal Forms: Evidence from French and Turkish

    ERIC Educational Resources Information Center

    Schimke, Sarah; Colonna, Saveria

    2016-01-01

    This study investigates the influence of grammatical role and discourse-level cues on the interpretation of different pronominal forms in native speakers of French, native speakers of Turkish, and Turkish learners of French. In written questionnaires, we found that native speakers of French were influenced by discourse-level cues when interpreting…

  3. Acquiring Orthographic Processing through Word Reading: Evidence from Children Learning to Read French and English

    ERIC Educational Resources Information Center

    Pasquarella, Adrian; Deacon, Helene; Chen, Becky X.; Commissaire, Eva; Au-Yeung, Karen

    2014-01-01

    This study examined the within-language and cross-language relationships between orthographic processing and word reading in French and English across Grades 1 and 2. Seventy-three children in French Immersion completed measures of orthographic processing and word reading in French and English in Grade 1 and Grade 2, as well as a series of control…

  4. Raising FLAGS: Renewing Core French at the Pre-Service Teacher Level

    ERIC Educational Resources Information Center

    Carr, Wendy

    2010-01-01

    A new program for core French teacher candidates called FLAGS (French Language and Global Studies) was established at the University of British Columbia (UBC) in 2007. The program is intended for those who are keen to teach core French and possess rudimentary proficiency in the language but may not necessarily have the same proficiency or prior…

  5. The Effects of Collaborative Models in Second Life on French Learning

    ERIC Educational Resources Information Center

    Hsiao, Indy Y. T.; Yang, Stephen J. H.; Chia-Jui, Chu

    2015-01-01

    French is the ninth most widely used language globally, but French-learning environments in Taiwan have been insufficient. Language acquisition is easier in a natural setting, and so such a setting should be available to language learners wherever possible. This study aimed to (1) create an authentic environment for learning French in Second Life…

  6. Phonetics, the Basis for All Levels of Proficiency in French Pronunciation.

    ERIC Educational Resources Information Center

    DiOrio, Dorothy M.

    French teachers need to realize and convince their supervisors that more time must be given to development of acceptable pronunciation and comprehension skills in the initial stages of French language study. Phonetics offers the technique and tools for perfecting pronunciation. The method for college French instruction described is adapted from…

  7. French and Spanish-Speaking Children Use Different Visual and Motor Units during Spelling Acquisition

    ERIC Educational Resources Information Center

    Kandel, Sonia; Valdois, Sylviane

    2006-01-01

    This study used a copying task to examine spelling acquisition in French and Spanish from a perception and action perspective. Experiment 1 compared French and Spanish-speaking monolingual children's performance. Experiment 2 analysed the behaviour of bilingual children when copying words in French and Spanish. Gaze lift analysis showed that in…

  8. French for "Hotellies": A Recently Instituted Course at the Cornell School of Hotel Administration.

    ERIC Educational Resources Information Center

    Grandjean-Levy, Andree

    The Cornell School of Hotel Administration in collaboration with the Department of Modern Languages and Linguistics offers a course in French for a small group of students who have had the equivalent of at least two semesters of college French. The course emphasizes oral/aural French with very little class time spent on grammar study. Grammar…

  9. French Bilingual Classes in Vietnam: Issues and Debates about an Innovative Language Curriculum

    ERIC Educational Resources Information Center

    Normand-Marconnet, Nadine

    2013-01-01

    Despite a long historical French presence in Vietnam, only 0.5% of Vietnamese people speak French today. As in other countries of South East Asia, language instruction in Vietnam has mainly focused on English for several decades. This paper provides an overview of a project called "French bilingual classes". The main aim of the study is…

  10. The Longitudinal Development of Clusters in French

    ERIC Educational Resources Information Center

    Demuth, Katherine; McCullough, Elizabeth

    2009-01-01

    Studies of English and German find that children tend to acquire word-final consonant clusters before word-initial consonant clusters. This order of acquisition is generally attributed to articulatory, frequency and/or morphological factors. This contrasts with recent experimental findings from French, where two-year-olds were better at producing…

  11. French Women in Physics: Status and Actions

    NASA Astrophysics Data System (ADS)

    Thibault, C.; Pépin, A.; Ducloy, M.; Giacobino, E.; Leduc, M.

    2009-04-01

    We present statistics on the underrepresentation of females entering scientific studies and on the persistence of a glass ceiling for women physicists—and female scientists in general—in France. We also examine actions taken by French research institutions, associations, companies, and professional societies since 2005 to improve these situations.

  12. Memory and Ideals in French Classrooms.

    ERIC Educational Resources Information Center

    Anderson-Levitt, Kathryn M.

    French elementary school teachers as well as the parents of their pupils remember being quiet students in teacher-dominated classrooms. Yet today both teachers and parents idealize lively classroom participation by their pupils or children. In this study, teachers and parents in an urban school district in Villefleurie, France, watched videotaped…

  13. Vocabulary Breadth in French L2 Learners

    ERIC Educational Resources Information Center

    David, Annabelle

    2008-01-01

    Vocabulary is one of the building blocks of language and is a necessary component of learners' development. This paper aims to describe the development of the L2 lexicon from the first year of learning French as a foreign language at school to the last year of undergraduate studies at university by setting out what learners know and how this…

  14. How to Find Out in: French.

    ERIC Educational Resources Information Center

    Robertson, Susan E.

    This library handbook is a guide for the student of French language and literature. It lists some of the more useful materials and reference books basic to general research and gives their locations in the Fogler Library at the University of Maine. Materials for language study include dictionaries and encyclopedias, histories of the language, and…

  15. [French immigration policy].

    PubMed

    Weil, P

    1994-01-01

    From the late nineteenth century through 1974, France permitted immigration to furnish workers and to compensate for the low level of fertility. Intense immigration from North Africa, the economic crisis of the 1970s, and other factors led to policy changes in 1974. French immigration policy since 1974 has fluctuated between guaranteeing foreigners equal rights regardless of their religion, race, culture, or national origin, and attempting to differentiate among immigrants depending on their degree of assimilability to French culture. From 1974 to 1988, France had five different policies regarding whether to permit new immigration and what to do about illegal immigrants. In July 1984, the four major political parties unanimously supported a measure in Parliament that definitively guaranteed the stay in France of legal immigrants, whose assimilation thus assumed priority. Aid for return to the homeland was no longer to be widely offered, and immigration of unskilled workers was to be terminated except for those originating in European Community countries. Major changes of government in 1988 and 1993 affected only the modalities of applying these principles. The number of immigrants has fluctuated since 1974. Unskilled workers, the only category whose entrance was specifically controlled by the 1984 measures, have declined from 174,000 in 1970 to 25,000 in the early 1990s. The number of requests for political asylum declined from 60,000 in 1989 to 27,000 in 1993, and in 1991, 15,467 persons were granted refugee status. The number of immigrants of all types permitted to remain in France declined from 250,000 or 3000 per year in the early 1970s to around 110,000 at present. Although the decline is significant, it appears insufficient to the government in power since 1993. Although migratory flows are often explained as the product of imbalance in the labor market or in demographic growth, the French experience suggests that government policies, both in the sending and

  16. Politics of public enterprise: oil and the French state

    SciTech Connect

    Feigenbaum, H.B.

    1985-01-01

    A study of 50 years of French petroleum policy, this book is a theoretical analysis of public enterprise and a general analysis of the relationship of state to society. The author reveals the French government's lack of actual control over French public enterprises in the oil industry. Demonstrating that French regulatory policy protects petroleum firms, he goes on to show that these firms fail to promote the state's goals and the public interest. French policy is molded by an ideological commitment to managerial autonomy and unfettered profits. The linkage of the state to society by elite recruitment, socialization, and career paths closes all but a limited number of policy options, with a resultant weakening of dedication to public goals. 83 references, 4 tables.

  17. A cross-sectional study of the health effects of work schedules on 3212 hospital workers in France: implications for the new French work schedules policy.

    PubMed

    Poissonnet, C M; Iwatsubo, Y; Cosquer, M; Quera Salva, M A; Caillard, J F; Veron, M

    2001-12-01

    This study was designed to investigate the effects of work schedules on the health of hospital workers at the Assistance Publique-Hôpitaux de Paris (AP-HP). Out of 40 hospitals, 17 volunteered to participate in this study. The Standard Shiftwork Index and a questionnaire concerning physicians' work schedules were used. Ten thousand questionnaires were distributed anonymously to hospital workers between March and April 1999. Professional categories comprised head nurses, nurses, nursing auxiliaries, hospital agents, midwives and full time physicians. Departments included internal and geriatric medicine, general paediatrics, orthopaedic and general surgery, operating and emergency rooms, and anaesthesiology and intensive care units. 3250 questionnaires were returned. Demographics for the respondents were: 79.2% female, average age 38.1 +/- 9.1 years old. Eleven work schedules were identified. One fourth of the personnel had fixed morning work schedules. The highest level of job satisfaction was found in personnel working in paediatrics while dissatisfaction was strongest in the gerontology and, emergency room personnel. General Health Questionnaire (GHQ) scores were high for head nurses, operating room nurses and junior doctors as well as for personnel with rotating and flexible shifts. This study will be used to make recommendations concerning the reduction of working time for French hospital workers.

  18. The French Revolution on Film: American and French Perspectives

    ERIC Educational Resources Information Center

    Harison, Casey

    2005-01-01

    It is not hard to locate negative or condescending images of the French Revolution in aspects of popular American culture, including film. Despite a handful of instances where nuanced or ambiguous "messages" may be identified, the number of American film interpretations of the French Revolution that might be judged historically…

  19. Invitation Refusals in Cameroon French and Hexagonal French

    ERIC Educational Resources Information Center

    Farenkia, Bernard Mulo

    2015-01-01

    Descriptions of regional pragmatic variation in French are lacking to date the focus has been on a limited range of speech acts, including apologies, requests, compliments and responses to compliments. The present paper, a systematic analysis of invitation refusals across regional varieties of French, is designed to add to the research on…

  20. Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women.

    PubMed

    Vercambre, Marie-Noël; Boutron-Ruault, Marie-Christine; Ritchie, Karen; Clavel-Chapelon, Françoise; Berr, Claudine

    2009-08-01

    The objective of the present study was to determine the potential long-term impact of dietary habits on age-related decline among 4809 elderly women (born between 1925 and 1930) in the 'Etude Epidémiologique de Femmes de la Mutuelle Générale de l'Education Nationale' (E3N) study, a French epidemiological cohort. In 1993, an extensive diet history self-administered questionnaire was sent to all participants, and in 2006 another questionnaire on instrumental activities of daily living (IADL) and recent cognitive change was sent to a close relative or friend of each woman. Logistic models adjusted for socio-demographic, lifestyle and health factors were performed to evaluate associations between habitual dietary intakes and two outcomes of interest based on the informant response: recent cognitive decline and IADL impairment. Recent cognitive decline was associated with lower intakes of poultry, fish, and animal fats, as well as higher intakes of dairy desserts and ice-cream. IADL impairment was associated with a lower intake of vegetables. The odds of recent cognitive decline increased significantly with decreasing intake of soluble dietary fibre and n-3 fatty acids but with increasing intake of retinol. The odds of IADL impairment increased significantly with decreasing intakes of vitamins B2, B6 and B12. These results are consistent with a possible long-term neuroprotective effect of dietary fibre, n-3 polyunsaturated fats and B-group vitamins, and support dietary intervention to prevent cognitive decline.

  1. Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women

    PubMed Central

    Vercambre, Marie-Noël; Boutron-Ruault, Marie-Christine; Ritchie, Karen; Clavel-Chapelon, Françoise; Berr, Claudine

    2009-01-01

    The objective of this study was to determine the potential long-term impact of dietary habits on age-related decline among 4,809 elderly women (born between 1925 and 1930) in the E3N study, a French longitudinal cohort. In 1993, an extensive diet history self-administered questionnaire was sent to all participants, and in 2006 another questionnaire on instrumental activities of daily living (IADL) and recent cognitive change was sent to a close relative/friend of each woman. Logistic models adjusted for sociodemographic, lifestyle and health factors were performed to evaluate associations between habitual dietary intakes and two outcomes of interest based on the informant response: recent cognitive decline and IADL impairment. Recent cognitive decline was associated with lower intakes of poultry, fish, and animal fats, as well as higher intakes of dairy dessert and ice-cream. IADL impairment was associated with lower intake of vegetables. The odds of recent cognitive decline increased significantly with decreasing intake of soluble dietary fibre and n-3 fatty acids but with increasing intake of retinol. The odds of IADL impairment increased significantly with decreasing intake of vitamins B2, B6, and B12. These results are consistent with a possible long-term neuroprotective effect of dietary fibre, n-3 polyunsaturated fats, and B-group vitamins, and support dietary intervention to prevent cognitive decline. PMID:19203415

  2. The relation of respiratory symptoms and ventilatory function to moderate occupational exposure in a general population. Results from the French PAARC study of 16,000 adults.

    PubMed

    Krzyzanowski, M; Kauffmann, F

    1988-06-01

    Data from the French PAARC (Pollution Atmosphérique et Affections Respiratoires Chroniques) study were used to assess the effect of a priori moderate occupational exposure to dust, gases or chemical fumes on the prevalence of respiratory symptoms and ventilatory function. In this community-based population, without households 'headed' by manual workers, 34% of the 8692 men and 23% of the 7772 women, 25-59 years of age, ever occupationally active, reported some exposure. The studied relationships were adjusted for age, height, smoking habits, socio-occupational class, education and air pollution by logistic or linear regression methods. For men and women, some 50% increase (p less than 0.01) in chronic cough, chronic bronchitis, dyspnoea grade 2 and wheezing prevalence was observed in the exposed group compared to the never exposed, with the strongest association for wheezing. FEV1 and FEF25-75% were not associated with occupational exposure. Among men, FEV1/FVC and FEF25-75%/FVC were significantly lower (p less than 0.001 and p less than 0.05) among the exposed compared to never exposed, but FVC was significantly greater (p less than 0.05). Among women, occupational exposure was significantly related to a lower FEV1/FVC in the subgroup with a history of asthma or wheezing. Results suggest that occupational exposures of relatively low intensity, encountered in the non-industrial work places may constitute a non-negligible risk for respiratory health.

  3. Low dose oestrogen combined oral contraception and risk of pulmonary embolism, stroke, and myocardial infarction in five million French women: cohort study

    PubMed Central

    Dalichampt, Marie; Raguideau, Fanny; Ricordeau, Philippe; Blotière, Pierre-Olivier; Rudant, Jérémie; Alla, François; Zureik, Mahmoud

    2016-01-01

    Objective To assess the risk of pulmonary embolism, ischaemic stroke, and myocardial infarction associated with combined oral contraceptives according to dose of oestrogen (ethinylestradiol) and progestogen. Design Observational cohort study. Setting Data from the French national health insurance database linked with data from the French national hospital discharge database. Participants 4 945 088 women aged 15-49 years, living in France, with at least one reimbursement for oral contraceptives and no previous hospital admission for cancer, pulmonary embolism, ischaemic stroke, or myocardial infarction, between July 2010 and September 2012. Main outcome measures Relative and absolute risks of first pulmonary embolism, ischaemic stroke, and myocardial infarction. Results The cohort generated 5 443 916 women years of oral contraceptive use, and 3253 events were observed: 1800 pulmonary embolisms (33 per 100 000 women years), 1046 ischaemic strokes (19 per 100 000 women years), and 407 myocardial infarctions (7 per 100 000 women years). After adjustment for progestogen and risk factors, the relative risks for women using low dose oestrogen (20 µg v 30-40 µg) were 0.75 (95% confidence interval 0.67 to 0.85) for pulmonary embolism, 0.82 (0.70 to 0.96) for ischaemic stroke, and 0.56 (0.39 to 0.79) for myocardial infarction. After adjustment for oestrogen dose and risk factors, desogestrel and gestodene were associated with statistically significantly higher relative risks for pulmonary embolism (2.16, 1.93 to 2.41 and 1.63, 1.34 to 1.97, respectively) compared with levonorgestrel. Levonorgestrel combined with 20 µg oestrogen was associated with a statistically significantly lower risk than levonorgestrel with 30-40 µg oestrogen for each of the three serious adverse events. Conclusions For the same dose of oestrogen, desogestrel and gestodene were associated with statistically significantly higher risks of pulmonary embolism but not arterial

  4. French intensive truck garden

    SciTech Connect

    Edwards, T D

    1983-01-01

    The French Intensive approach to truck gardening has the potential to provide substantially higher yields and lower per acre costs than do conventional farming techniques. It was the intent of this grant to show that there is the potential to accomplish the gains that the French Intensive method has to offer. It is obvious that locally grown food can greatly reduce transportation energy costs but when there is the consideration of higher efficiencies there will also be energy cost reductions due to lower fertilizer and pesticide useage. As with any farming technique, there is a substantial time interval for complete soil recovery after there have been made substantial soil modifications. There were major crop improvements even though there was such a short time since the soil had been greatly disturbed. It was also the intent of this grant to accomplish two other major objectives: first, the garden was managed under organic techniques which meant that there were no chemical fertilizers or synthetic pesticides to be used. Second, the garden was constructed so that a handicapped person in a wheelchair could manage and have a higher degree of self sufficiency with the garden. As an overall result, I would say that the garden has taken the first step of success and each year should become better.

  5. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.

    PubMed

    Dastani, Zari; Pajukanta, Päivi; Marcil, Michel; Rudzicz, Nicholas; Ruel, Isabelle; Bailey, Swneke D; Lee, Jenny C; Lemire, Mathieu; Faith, Janet; Platko, Jill; Rioux, John; Hudson, Thomas J; Gaudet, Daniel; Engert, James C; Genest, Jacques

    2010-03-01

    Low levels of high-density lipoprotein cholesterol (HDL-C) are an independent risk factor for cardiovascular disease. To identify novel genetic variants that contribute to HDL-C, we performed genome-wide scans and quantitative association studies in two study samples: a Quebec-wide study consisting of 11 multigenerational families and a study of 61 families from the Saguenay-Lac St-Jean (SLSJ) region of Quebec. The heritability of HDL-C in these study samples was 0.73 and 0.49, respectively. Variance components linkage methods identified a LOD score of 2.61 at 98 cM near the marker D16S515 in Quebec-wide families and an LOD score of 2.96 at 86 cM near the marker D16S2624 in SLSJ families. In the Quebec-wide sample, four families showed segregation over a 25.5-cM (18 Mb) region, which was further reduced to 6.6 Mb with additional markers. The coding regions of all genes within this region were sequenced. A missense variant in CHST6 segregated in four families and, with additional families, we observed a P value of 0.015 for this variant. However, an association study of this single-nucleotide polymorphism (SNP) in unrelated Quebec-wide samples was not significant. We also identified an SNP (rs11646677) in the same region, which was significantly associated with a low HDL-C (P=0.016) in the SLSJ study sample. In addition, RT-PCR results from cultured cells showed a significant difference in the expression of CHST6 and KIAA1576, another gene in the region. Our data constitute additional evidence for a locus on chromosome 16q23-24 that affects HDL-C levels in two independent French-Canadian studies.

  6. The French Revolution and "Revisionism."

    ERIC Educational Resources Information Center

    Langlois, Claude

    1990-01-01

    Outlines revisionist interpretations of the French Revolution that challenged the dominant historiographical tradition during the 1950s and 1960s. Distinguishes four central characteristics of revisionist works. Identifies a key split in current French Revolution historiography between reflection on nineteenth-century…

  7. French for Journalists: Classroom Techniques.

    ERIC Educational Resources Information Center

    Rodina, Herta

    The use of authentic materials for an advanced French course for students of journalism and communication has the drawback that authentic French sources assume a regular, informed readership sharing the same culture and history. A solution found at Ohio University is to use a publication that bridges the two cultures, such as the "Journal…

  8. A cost-minimization of heart failure therapy with bisoprolol in the French setting: an analysis from CIBIS trial data. Cardiac Insufficiency Bisoprolol Study.

    PubMed

    Levy, P; Lechat, P; Leizorovicz, A; Levy, E

    1998-07-01

    Beta-blocker-induced benefit in heart failure is under intense evaluation. Several large-scale mortality trials are currently being performed, with CIBIS II evaluating bisoprolol. The economic impact of beta-blocker therapy in heart failure has not been previously determined. The present study is a cost-effectiveness evaluation of bisoprolol treatment based on CIBIS I data. It considers direct costs, that is, the bisoprolol medication cost and the cost of hospitalization related to heart failure and its complications. Hospitalization costs were calculated from the French system of classification (PMSI), which provides costs according to homogeneous groups of patients (GHM). The cost difference between bisoprolol and placebo in the entire CIBIS population and the trial duration result from an increase in cost caused by bisoprolol treatment (+ 2018 Frs/patient) and a decrease in cost related to reduced hospitalization (6349 Frs/patient). A total savings per patient of about 4330 Frs was produced by bisoprolol. Cost reduction is still more pronounced in patients not having a history of myocardial infarction. We conclude that heart failure therapy with bisoprolol lowers medical healthcare costs, mainly due to the reduced rate of hospital admissions for heart failure.

  9. Relative contribution of structural inheritance and glacial morphology on the post-glacial slope destabilization. The Séchilienne slope case study (French western Alps).

    NASA Astrophysics Data System (ADS)

    Schwartz, Stéphane; Zerathe, Swann; Audin, Laurence; Dumont, Thierry; Jarre, Raphael; Jongmans, Denis; Carcaillet, Julien; Dubois, Laurent

    2016-04-01

    In the main Alpine valleys, the chronological constraints about the onset of the slope movements following glacial retreat are scarse. The southern part of the Belledonne massif (French western Alps) along the Romanche valley is affected by numerous slope destabilizations. A detailed geomorphological study using a high resolution LIDAR digital model elevation, allows to characterize the structural framework, the evolution of the glacial retreat and the distribution of the gravitational instabilities. The systematic survey of (i) the main fracturing and (ii) the glacial and gravity morphological witness along the slopes of the Romanche valley coupled with (iii) cosmogenic 10Be dating provides a regional view of the dynamics of slope destabilisation in this area. The proposed scenario allows to evaluate the relative influence of different triggering factors such as seismo-tectonic stresses and climatic changes. These data also allow to propose a consistent dynamic destabilization model of a major lanslide (> 100×106 m3) in relation with the last episode of glacial retreat ~ 21ka ago.

  10. Prognostic value of isolated tumor cells and micrometastases of lymph nodes in early-stage breast cancer: a French sentinel node multicenter cohort study.

    PubMed

    Houvenaeghel, Gilles; Classe, Jean-Marc; Garbay, Jean-Rémy; Giard, Sylvia; Cohen, Monique; Faure, Christelle; Hélène, Charytensky; Belichard, Catherine; Uzan, Serge; Hudry, Delphine; Azuar, Pierre; Villet, Richard; Penault Llorca, Frédérique; Tunon de Lara, Christine; Goncalves, Anthony; Esterni, Benjamin

    2014-10-01

    To define the prognostic value of isolated tumor cells (ITC), micrometastases (pN1mi) and macrometastases in early stage breast cancer (ESBC). We conducted a retrospective multicenter cohort study at 13 French sites. All the eligible patients who underwent SLNB from January 1999 to December 2008 were identified, and appropriate data were extracted from medical records and analyzed. Among 8001 patients, including 70% node-negative (n = 5588), 4% ITC (n = 305), 10% pN1mi (n = 794) and 16% macrometastases (n = 1314) with a median follow-up of 61.3 months, overall survival (OS) and recurrence-free survival (RFS) rates at 84 months were not statistically different in ITC or pN1mi compared to tumor-free nodes. Axillary recurrence (AR) was significantly more frequent in ITC (1.7%) and pN1mi (1.5%) compared to negative nodes (0.6%). Survival and AR rates of single macrometastases were not different from those of ITC or pN1mi. In case of 2 macrometastases or more, survival rates decreased and recurrence rates increased significantly. Micrometastases and ITC do not have a negative prognostic value. Single macrometastases might have an intermediate prognostic value while 2 macrometastases or more are associated with poorer prognosis.

  11. Neighbourhood socio-economic characteristics and the risk of preterm birth for migrant and non-migrant women: a study in a French district.

    PubMed

    Zeitlin, Jennifer; Combier, Evelyne; Levaillant, Marc; Lasbeur, Linda; Pilkington, Hugo; Charreire, Helene; Rivera, Lucile

    2011-07-01

    Neighbourhood-level deprivation is associated with preterm birth; preterm birth rates are also higher for some, but not all migrant groups. We studied the impact of neighbourhood characteristics (a deprivation score and the proportion of foreign-born residents) on singleton preterm birth in the French district of Seine-Saint-Denis for women born in France, North Africa, sub-Saharan Africa and other countries. Multilevel logistic regression models were adjusted for maternal demographic and health care characteristics. For women born in France, the preterm birth rate rose with neighbourhood deprivation quintile (3.8% in the first to 5.7% in the fifth, adjusted odds ratio: 1.40 [95% confidence interval 1.14, 1.72]) and with increasing proportions of foreign-born residents. Preterm birth rates were not higher in more deprived neighbourhoods for women born outside of France and were lower in neighbourhoods with more foreign-born residents; in multilevel models, the inverse association with deprivation remained significant for women from sub-Saharan Africa. Area-based deprivation measures should be used with caution in populations with large numbers of migrants. These results raise questions about the health benefits of clustering for migrant communities as well as the negative consequences of acculturation.

  12. Ice cloud microphysics study from combined active and passive radiometric observations in visible and thermal infrared domains during FRENCH-DIRAC campaign.

    NASA Astrophysics Data System (ADS)

    Bécu, L.; Brogniez, G.; Parol, F.; Pelon, J.; Gayet, J. F.; Auriol, F.; Balois, J. Y.; Verwearde, C.; Damiri, B.

    2003-04-01

    Radiative properties of cirrus clouds in relation to their microphysical characteristics were studied during the airborne FRENCH-DIRAC campaign. It was held in September/October 2001 in south western France and over the Mediterranean sea. During this campaign, two aircrafts were involved. A TBM 700 aircraft devoted to insitu measurements has carried out a 2D-C probe and a nephelometer sensor. A Mystere 20 aircraft devoted to remote sensing measurements has carried out a backscatter lidar with polarisation capability (LEANDRE), a three channel infrared radiometer (CLIMAT), an imaging polarisation radiometer (POLDER) operating in the shortwave domain, and a visible-near infrared polarimeter (MINIMIR). As an example, we particularly focus this presentation on the synergy between LEANDRE, CLIMAT, and POLDER instruments in order to analyse radiative parameters and microphysical characteristics of an evidenced mixed phase cloud with a transition between liquid and solid phase of water at one km-scale. We show how the combined lidar and radiometry measurements are complementing each others to characterise such a complex cloud structure and better retrieve cloud properties.

  13. Acquisition of Requests and Apologies in Spanish and French: Impact of Study Abroad and Strategy-Building Intervention

    ERIC Educational Resources Information Center

    Cohen, Andrew D.; Shively, Rachel L.

    2007-01-01

    The primary aim of this study was to assess the impact of a curricular intervention on study-abroad students' use of language- and culture-learning strategies and on their acquisition of requests and apologies. The intervention consisted of a brief face-to-face orientation to learning speech acts, a self-study guidebook on language and culture…

  14. Status of French reactors

    SciTech Connect

    Ballagny, A.

    1997-08-01

    The status of French reactors is reviewed. The ORPHEE and RHF reactors can not be operated with a LEU fuel which would be limited to 4.8 g U/cm{sup 3}. The OSIRIS reactor has already been converted to LEU. It will use U{sub 3}Si{sub 2} as soon as its present stock of UO{sub 2} fuel is used up, at the end of 1994. The decision to close down the SILOE reactor in the near future is not propitious for the start of a conversion process. The REX 2000 reactor, which is expected to be commissioned in 2005, will use LEU (except if the fast neutrons core option is selected). Concerning the end of the HEU fuel cycle, the best option is reprocessing followed by conversion of the reprocessed uranium to LEU.

  15. [Use of radionuclide isotopes by cardiologists. Results of a French survey. Study group: "Nuclear Cardiology" of the French Society of Cardiology and the Society of Nuclear Medicine and Biophysics].

    PubMed

    Pézard, P; Karcher, G

    1995-03-01

    The authors report the results of an enquiry carried out amongst French cardiologists to determine their opinion about radionuclide investigations in cardiological practice. Of the 5,050 cardiologists contacted, 1,431 (28.3%) replied. The cardiologists were attracted by the non-invasive nature (84%) of radionuclide techniques and their complementarity with other methods of investigation (74%) but regretted their cost (55%), their lick of availability in emergencies (35%) and, in general, their difficult of access (30%). Only 38% of the cardiologists who replied used radionuclide investigation on an everyday basis, this being impossible for some because of the distance to the nearest centre with these facilities (on average 32 km but exceeding 50 km in 29% of cases, and the delay before obtaining an appointment (average 13 days) which was often excessive, especially for myocardial scintigraphy (thallium or equivalent). Each cardiologist prescribed an average of 5 myocardial scintigraphies, 3 pulmonary scintigraphies and 2 radioisotopic ventriculography per month. These results seem to be an overestimation; in fact, radionuclide investigations are relatively underemployed, probably more because of the factors cited above than because of lack interest or quality, these latter two points being generally judged positively by the majority of cardiologists. Cardiologists require more from the conclusions of the investigation than a simple description of the images obtained. As with all other investigations that they perform themselves, the interpretation of the results must take the clinical context into consideration and form part of the diagnostic and therapeutic management of the patient.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Is What's Good for the Goose Good for the Gander? The Case of Male and Female Encouragement to Study French

    ERIC Educational Resources Information Center

    Kissau, Scott

    2007-01-01

    Male disinterest in second and foreign language programs has been well documented in recent years. The influence of encouragement to study languages also has been thoroughly investigated. There is, however, little research that connects these two phenomena. This study investigated if gender differences exist in the amount of encouragement students…

  17. The Effectiveness of Written Recasts in the Second Language Acquisition of Aspectual Distinctions in French: A Follow-Up Study

    ERIC Educational Resources Information Center

    Ayoun, Dalila

    2004-01-01

    This follow-up study on the acquisition of the aspectual distinction between the pass compos (PC) and the imparfait (IMP) investigates the differential outcomes of the results presented in an earlier study, Ayoun (2001), by pursuing two lines of research: the effectiveness of written recasts versus models and traditional grammar instruction, and…

  18. A Cross-Cultural Study on Meaning and the Nature of Children's Experiences in Australian and French Swimming Clubs

    ERIC Educational Resources Information Center

    Light, Richard

    2010-01-01

    This article reports on a study conducted in Australia and France that inquired into the meaning and the nature of children's experiences of being in swimming clubs with a focus on the positive aspects of membership that keep them in their clubs. Three-month long case studies were conducted in a club in Australia and in a club in France, employing…

  19. Why Children Join and Stay in Sports Clubs: Case Studies in Australian, French and German Swimming Clubs

    ERIC Educational Resources Information Center

    Light, Richard L.; Harvey, Stephen; Memmert, Daniel

    2013-01-01

    This article builds upon research on youth sport clubs conducted from a socio-cultural perspective by reporting on a study that inquired into the reasons why children aged 9-12 joined swimming clubs in France, Germany and Australia. Comprising three case studies it employed a mixed method approach with results considered within the framework of…

  20. Low predictive value of PGL-I serology for the early diagnosis of leprosy in family contacts: results of a 10-year prospective field study in French Polynesia.

    PubMed

    Chanteau, S; Glaziou, P; Plichart, C; Luquiaud, P; Plichart, R; Faucher, J F; Cartel, J L

    1993-12-01

    In 1983, a cohort study to follow up the family contacts of leprosy cases was implemented in French Polynesia to assess the usefulness and applicability of phenolic glycolipid-I (PGL-I) serology in a leprosy control program. A total of 1201 contacts (666 females, 535 males) have been included in the study. The IgM anti-PGL-I seroprevalence determined on the initial sera was 17%. It was significantly higher among females than males (20% vs 15%, p = 0.02). From 1983 to 1992, 4 out of 204 (2%) anti-PGL-I seropositive contacts developed the disease (1 indeterminate, 1 BT, 1 BL, 1 LL) compared with 10 out of 997 (1%) seronegative contacts (4 indeterminate, 3 BT, 1 BB, 2 TT). Of these 10 patients, only 3 (2 indeterminate, 1 BT) converted to seropositivity when leprosy was diagnosed. The risk of developing leprosy was not significantly higher among seropositive than among seronegative groups (2% vs 1%, p = 0.2). A PGL-I circulating antigen test performed on 216 selected sera at entry into the trial showed a higher antigen prevalence when the antibody level was higher. PGL-I antigen was detectable in 5 of 12 patients tested prior to diagnosis (1 LL, 1 BL, 3 indeterminate). The median time to externalize the disease was not significantly different among antibody-positive and -negative contacts (17 vs 25 months, p = 0.3). The relative risk of developing leprosy for contact individuals was 30.8 times that of noncontacts, and 15% of the total new cases detected between 1983 and 1992 emerged from the study population.(ABSTRACT TRUNCATED AT 250 WORDS)

  1. Intrinsic and Extrinsic Motivation, Orientation and Achievements in L2 of Arab Learners of English, French and German: A Study from Jordan

    ERIC Educational Resources Information Center

    Kreishan, Lana J.; Al-Dhaimat, Yahya

    2013-01-01

    The aim of this research is to explore Jordanian undergraduate students' intrinsic and extrinsic motivations and instrumental and integrative orientations toward learning English, French, and German as foreign languages. The paper also reflects on how subtypes of intrinsic and extrinsic motivations relate to orientations and examines possible…

  2. L2 vs. L3 Initial State: A Comparative Study of the Acquisition of French DPs by Vietnamese Monolinguals and Cantonese-English Bilinguals

    ERIC Educational Resources Information Center

    Leung, Yan-Kit Ingrid

    2005-01-01

    This paper compares the initial state of second language acquisition (L2A) and third language acquisition (L3A) from the generative linguistics perspective. We examine the acquisition of the Determiner Phrase (DP) by two groups of beginning French learners: an L2 group (native speakers of Vietnamese who do not speak any English) and an L3 group…

  3. Vocabulary Use during Conversation: A Cross-Sectional Study of Development from Year 9 to Year 13 among Learners of Spanish and French

    ERIC Educational Resources Information Center

    Marsden, Emma; David, Annabelle

    2008-01-01

    The aim of this paper is to describe vocabulary use during semi-spontaneous oral production among instructed learners of French and Spanish at two different stages in the UK educational system: year 9 (near beginners) and year 13 (approximately low-intermediates). The paper mainly focuses on comparing lexical diversity (range or variety of…

  4. From eradication to containment: invasion of French Polynesia by Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) and releases of two natural enemies: a 17-year case study

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Oriental fruit fly, Bactrocera dorsalis (Hendel), was discovered on Tahiti Island, French Polynesia, in 1996. Two other economically important Bactrocera species were previously established: B. kirki (Froggatt) in 1928, and B. tryoni (Froggatt), Queensland fruit fly, in 1970. This situation provi...

  5. Processing Tense/Aspect-Agreement Violations On-Line in the Second Language: A Self-Paced Reading Study with French and German L2 Learners of English

    ERIC Educational Resources Information Center

    Roberts, Leah; Liszka, Sarah Ann

    2013-01-01

    In this article, we report the results of a self-paced reading experiment designed to investigate the question of whether or not advanced French and German learners of English as a second language (L2) are sensitive to tense/aspect mismatches between a fronted temporal adverbial and the inflected verb that follows (e.g. *"Last week, James has…

  6. Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)

    PubMed Central

    Cardoso, Rita; Mercier, Céline; Santos, Helena; Atkinson-Clement, Cyril; Carvalho, Joana; Welby, Pauline; Oliveira, Pedro; D'Imperio, Mariapaola; Frota, Sónia; Letanneux, Alban; Vigario, Marina; Cruz, Marisa; Martins, Isabel Pavão; Viallet, François

    2016-01-01

    Introduction Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese). Methods and analysis Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life. Ethics and dissemination The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided

  7. Risk of neuroblastoma, birth-related characteristics, congenital malformations and perinatal exposures: A pooled analysis of the ESCALE and ESTELLE French studies (SFCE).

    PubMed

    Rios, Paula; Bailey, Helen D; Orsi, Laurent; Lacour, Brigitte; Valteau-Couanet, Dominique; Levy, Dominique; Corradini, Nadège; Leverger, Guy; Defachelles, Anne-Sophie; Gambart, Marion; Sirvent, Nicolas; Thebaud, Estelle; Ducassou, Stéphane; Clavel, Jacqueline

    2016-11-01

    Neuroblastoma (NB), an embryonic tumour arising from neural crest cells, is the most common malignancy among infants. The aetiology of NB is largely unknown. We conducted a pooled analysis to explore whether there is an association between NB and preconception and perinatal factors using data from two French national population-based case-control studies. The mothers of 357 NB cases and 1783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on demographic, socioeconomic and perinatal characteristics, childhood environment, life-style and maternal reproductive history. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. After controlling for matching variables, study of origin and potential confounders, being born either small (OR 1.4 95% CI 1.0-2.0) or large (OR 1.5 95% CI 1.1-2.2) for gestational age and, among children younger than 18 months, having congenital malformations (OR 3.6 95% CI 1.3-8.9), were significantly associated with NB. Inverse associations were observed with breastfeeding (OR 0.7 95% CI 0.5-1.0) and maternal use of any supplements containing folic acid, vitamins or minerals (OR 0.5 95% CI 0.3-0.9) during the preconception period. Our findings reinforce the hypothesis that fetal growth anomalies and congenital malformations may be associated with an increased risk of NB. Further investigations are needed in order to clarify the role of folic acid supplementation and breastfeeding, given their potential importance in NB prevention.

  8. Middle-term mortality and re-bleeding after initial diverticular bleeding: A nationwide study of 365 mostly elderly French patients

    PubMed Central

    Lorenzo, Diane; Gallois, Claire; Lahmek, Pierre; Lesgourgues, Bruno; Champion, Christine; Charpignon, Claire; Faroux, Roger; Bour, Bruno; Remy, André-Jean; Naouri, Chantal; Picon, Magali; Poncin, Eric; Macaigne, Gilles; Seyrig, Jacques-Arnaud; Bernardini, David; Bellaïche, Guy; Grasset, Denis; Henrion, Jean; Heluwaert, Frédéric; Piperaud, René; Bordes, Gilbert; Bourhis, Francois; Arpurt, Jean-Pierre; Pariente, Alexandre

    2016-01-01

    Background and aims The aim of this study was to determine the mortality and re-bleeding rates, and the risk factors involved, in a cohort of patients with previous diverticular bleeding (DB). Methods In 2007, data on 2462 patients with lower gastrointestinal (GI) bleeding were collected prospectively at several French hospitals. We studied the follow-up of patients with DB retrospectively. The following data were collected: age, mortality rates and re-bleeding rates, drug intake, surgery and comorbidities. Results Data on 365 patients, including 181 women (mean age 83.6 ± 9.8 years) were available. The median follow-up time was 3.9 years (IQR 25–75: 1.7–5.4). Of these, 148 patients died (40.5%). Among the 70 patients (19.2%) who had at least one re-bleeding episode, nine died and three underwent surgical procedures. Anticoagulation and antiplatelet therapy was discontinued in 70 cases (19.2%). The independent risk factors contributing to mortality were age > 80 years (HR = 3.18 (2.1–4.9); p < 0.001) and a Charlson comorbidity score > 2 (1.91 (1.31–2.79); p = 0.003). Discontinuation of therapy was not significantly associated with a risk of death due to cardiovascular events. No risk factors responsible for re-bleeding were identified, such as antiplatelet and anticoagulant therapy in particular. Conclusions In this cohort, the rates of mortality and DB re-bleeding after a median follow-up time of 3.9 years were 19.2% and 40.5%, respectively. The majority of the deaths recorded were not due to re-bleeding.

  9. Resistance and virulence potential of uropathogenic Escherichia coli strains isolated from patients hospitalized in urology departments: a French prospective multicentre study.

    PubMed

    Lavigne, Jean-Philippe; Bruyère, Franck; Bernard, Louis; Combescure, Christophe; Ronco, Esthel; Lanotte, Philippe; Coloby, Patrick; Thibault, Michel; Cariou, Gérard; Desplaces, Nicole; Costa, Pierre; Sotto, Albert

    2016-06-01

    We characterized antibiotic resistance and virulence of uropathogenic Escherichia coli (UPEC) strains isolated from urinary tract infections (UTIs) in patients hospitalized in urology departments. A prospective multicentre study was initiated from March 2009 and lasted until February 2010 in French urology units. All patients with asymptomatic bacteriuria (ABU), acute cystitis, acute pyelonephritis or acute prostatitis in whom UPEC was detected were included. Antimicrobial resistance and virulence factors were compared among the different groups. To identify independent associations between virulence markers and the risk of UTI, we used a multivariate logistic regression. We included 210 patients (mean age: 65.8 years; 106 female). Episode of UTI was community acquired in 72.4 %. ABU was diagnosed in 67 cases (31.9 %), cystitis in 52 cases (24.7 %), pyelonephritis in 35 cases (16.7 %) and prostatitis in 56 cases (26.7 %). ABU was more frequent in patients with a urinary catheter (76.1 vs 23.9 %, P<0.001). The resistance rate was 7.6 and 24.8 % for cefotaxime and ciprofloxacin, respectively. UPEC isolated from infections belonged more frequently to phylotypes B2 and D (P =0.07). The papG allele II and papA, papC, papE, kpsMTII and iutA genes were significantly more frequent in infecting strains (P<0.05). In multivariate analysis, strains susceptible to ciprofloxacin were significantly associated with papG allele II (P=0.007), kpsMTK1 (P<0.001) and hlyA (P<0.001) compared with the ciprofloxacin-resistant strains. To the best of our knowledge, this is the first study evaluating the antibiotic resistance and virulence features of UPEC isolated from patients hospitalized in urology departments. High resistance rates were observed, notably for ciprofloxacin, highlighting the importance of a reinforced surveillance in this setting.

  10. The Intensity of Primary Care for Heart Failure Patients: A Determinant of Readmissions? The CarPaths Study: A French Region-Wide Analysis

    PubMed Central

    Solecki, Kamila; Papinaud, Laurence; Georgescu, Vera; Roubille, François; Mercier, Gregoire

    2016-01-01

    Background We aimed to classify patients with heart failure (HF) by the style of primary care they receive. Methods and Results We used the claim data (SNIIRAM: Système National d’Information Inter-Régime de l’Assurance Maladie) of patients living in a French region. We evaluated three concepts. First, baseline clinical status with age and Charlson index. Second, primary care practice style with mean delay between consultations, quantity of nursing care, and variability of diuretic dose. Third, clinical outcomes with death during follow-up, readmission for HF, and rate of unforeseen consultations. The baseline clinical status and the clinical outcomes were included to give an insight in the reasons for, and performance of, primary care practice style. Patients were classified using a hierarchical ascending classification based on principal components. A total of 2,751 patients were included in this study and were followed for a median of 22 months. The mean age was 78 y (SD: 12); 484 (18%) died, and 818 (30%) were readmitted for HF. We found three different significant groups characterized by their need for care and the intensity of practice style: group 1 (N = 734) was “low need-low intensity”; group 2 (N = 1,060) was “high need-low intensity”; and group 3 (N = 957) was “high need-high intensity”. Their readmission rates were 17%, 41% and 28%, respectively. Conclusions This study evaluated the link between primary care, clinical status and main clinical outcomes in HF patients. In higher need patients, a low-intensity practice style was associated with poorer clinical outcomes. PMID:27727296

  11. A preliminary investigation of farm-level risk factors for cattle condemnation at the slaughterhouse: a case-control study on French farms.

    PubMed

    Deschamps, Jean-Baptiste; Calavas, Didier; Mialet, Sylvie; Gay, Emilie; Dupuy, Céline

    2013-11-01

    The financial impact of condemnation for farmers and the importance of efficiency in the meat inspection process to guarantee food safety are well known. Identifying farm-level risk factors for condemnation are useful in order to find a way for farmers to potentially reduce their condemnation rates and to build a risk-based farm classification for veterinary services to target both meat inspection and farms inspections. To our knowledge, this has not yet been done, probably due to a lack of available meat inspection data. A preliminary investigation was performed through a case-control study on 36 French farms, from a dairy production region to identify farm-level risk factors for high condemnation rates (i.e. more than 45% of cattle with at least one portion of the carcass condemned). Multivariable exact logistic regression was performed to take into account the small sample size. The final model identified two significant risk factors. The odds of having a high condemnation rate was at least twice as greater for farmers who did not adhere to the quality charter of an international retailer and was significantly higher when the most qualified worker on the farm had a degree in agriculture. This latter effect was unexpected and is reviewed in the discussion section. The protective effect of the quality charter could be explained by the annual control of farms performed to guarantee compliance with good farming practices in the adhering farms. It led us to believe that compliance with well known good farming practices could be a way for farmers to reduce their condemnation rates. This study is a preliminary investigation performed on a small sample size of farms that were mainly dairy farms. It is a first step for further investigations that need to be done on this topic at a larger scale to fill the current lack of knowledge.

  12. Risk factors for death and the 3-year survival of patients with systemic sclerosis: the French ItinérAIR-Sclérodermie study

    PubMed Central

    Carpentier, Patrick; Gressin, Virginie; Diot, Elisabeth; Allanore, Yannick; Sibilia, Jean; Launay, David; Mouthon, Luc; Jego, Patrick; Cabane, Jean; de Groote, Pascal; Chabrol, Amélie; Lazareth, Isabelle; Guillevin, Loïc; Clerson, Pierre; Humbert, Marc

    2009-01-01

    Objectives. This longitudinal study investigated survival, risk factors and causes of death in the multicentre ItinérAIR-Sclérodermie cohort of patients with SSc without severe pulmonary fibrosis or severe left heart disease at baseline. Methods. At 3-year follow-up, vital status was obtained from investigators or French national death records. Causes of death were classified as SSc-related or otherwise. Data were censored at 37 months, time of death or loss to follow-up, whichever was earlier. Survival was estimated using the Kaplan–Meier method. Multivariate survival analyses were conducted using the Cox model. Results. In total, 546 patients were followed for a median duration of 37 months, representing 1547 patient-years. At baseline, the majority of patients were female, with lcSSc, mean age 54.9 ± 13.0 years and mean duration of SSc of 8.8 ± 8.1 years. In total, 47 patients died, giving a 3-year survival of 91.1% and cumulative mortality of 3.04 deaths per 100 patient-years; 17 deaths (32.2%) resulted from pulmonary arterial hypertension (PAH) and eight (17.1%) from cancer. Of the 47 patients with PAH at baseline, 20 died during follow-up, giving a 3-year survival of 56.3%. In a multivariate analysis, PAH [hazard ratio (HR) 7.246], age at first symptom (HR 1.052), duration of SSc (HR 1.047 per year) and Rodnan skin score (per one point) (HR 1.045) were associated with increased mortality. Conclusion. This 3-year study observed survival and mortality estimates that were comparable with previous reports. PAH increased the HR for mortality in patients with SSc, justifying yearly echocardiographic screening. PMID:19174571

  13. Integration of production and financial models to analyse the financial impact of livestock diseases: a case study of Schmallenberg virus disease on British and French dairy farms

    PubMed Central

    Häsler, Barbara; Alarcon, Pablo; Raboisson, Didier; Waret-Szkuta, Agnes; Rushton, Jonathan

    2015-01-01

    Aims and objectives The aim of the study was to investigate and compare the financial impact of Schmallenberg disease for different dairy production types in the United Kingdom and France. Materials and methods Integrated production and financial models for dairy cattle were developed and applied to Schmallenberg virus (SBV) disease in a British and French context. The five main production systems that prevail in these two countries were considered. Their respective gross margins measuring the holding's profitability were calculated based on public benchmarking, literature and expert opinion data. A partial budget analysis was performed within each production model to estimate the impact of SBV in the systems modelled. Two disease scenarios were simulated: low impact and high impact. Results The model gross margin obtained per cow space and year ranged from £1014 to £1484 for the UK and from £1037 to £1890 for France depending on the production system considered. In the UK, the net SBV disease costs in £/cow space/year for an average dairy farm with 100 milking spaces were estimated between £16.3 and £51.4 in the high-impact scenario and between £8.2 and £25.9 in the low-impact scenario. For France, the net SBV disease costs in £/cow space/year ranged from £19.6 to £48.6 in the high-impact scenario and £9.7 to £22.8 in the low-impact scenario, respectively. Conclusion The study illustrates how the combination of production and financial models allows assessing disease impact taking into account differing management and husbandry practices and associated price structures in the dairy sector. It supports decision-making of farmers and veterinarians who are considering disease control measures as it provides an approach to estimate baseline disease impact in common dairy production systems in the UK and France. PMID:26392883

  14. Wine consumption throughout life is inversely associated with type 2 diabetes risk, but only in overweight individuals: results from a large female French cohort study.

    PubMed

    Fagherazzi, Guy; Vilier, Alice; Lajous, Martin; Boutron-Ruault, Marie-Christine; Balkau, Beverley; Clavel-Chapelon, Françoise; Bonnet, Fabrice

    2014-11-01

    Alcohol has previously been shown to have a U-shaped association with type 2 diabetes (T2D) risk, but less is known regarding the specific association with wine. To evaluate for the first time the associations between T2D risk and both baseline wine consumption and trajectories of wine consumption frequency throughout life, estimated using an innovative group-based trajectory modeling strategy. A total of 66,485 women from the French prospective E3N-EPIC cohort were followed between 1993 and 2007; 1,372 incident cases of T2D were diagnosed during the follow-up. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (95 % CI) for T2D risk. The average consumption of wine, among alcohol consumers, was 0.81 drinks/day (1 drink = 150 mL). Associations between wine and T2D were restricted to overweight women (P interaction = 0.0084). Among them, wine consumption was inversely associated with T2D risk (P trend = 0.0022). A lower risk was observed for overweight women having two or more drinks/day [HR 0.59 (0.43-0.82)] when compared with non-alcohol consumers. Women who started to drink wine early in life (around age 10-15 years) were at a significantly lower risk than lifetime abstainers. In our study, wine drinking was inversely associated with T2D risk but only in overweight women. Our results also suggest a potential beneficial, cumulative effect of moderate wine consumption throughout life for overweight women, who would already be at higher risk of T2D. We encourage other cohort studies with information on wine consumption to investigate these associations.

  15. Qualitative and Semiquantitative Assessment of Exposure to Engineered Nanomaterials within the French EpiNano Program: Inter- and Intramethod Reliability Study.

    PubMed

    Guseva Canu, Irina; Jezewski-Serra, Delphine; Delabre, Laurène; Ducamp, Stéphane; Iwatsubo, Yuriko; Audignon-Durand, Sabine; Ducros, Cécile; Radauceanu, Anca; Durand, Catherine; Witschger, Olivier; Flahaut, Emmanuel

    2017-01-01

    The relatively recent development of industries working with nanomaterials has created challenges for exposure assessment. In this article, we propose a relatively simple approach to assessing nanomaterial exposures for the purposes of epidemiological studies of workers in these industries. This method consists of an onsite industrial hygiene visit of facilities carried out individually and a description of workstations where nano-objects and their agglomerates and aggregates (NOAA) are present using a standardized tool, the Onsite technical logbook. To assess its reliability, we implemented this approach for assessing exposure to NOAA in workplaces at seven workstations which synthesize and functionalize carbon nanotubes. The prediction of exposure to NOAA using this method exhibited substantial agreement with that of the reference method, the latter being based on an onsite group visit, an expert's report and exposure measurements (Cohen kappa = 0.70, sensitivity = 0.88, specificity = 0.92). Intramethod comparison of results for exposure prediction showed moderate agreement between the three evaluators (two program team evaluators and one external evaluator) (weighted Fleiss kappa = 0.60, P = 0.003). Interevaluator reliability of the semiquantitative exposure characterization results was excellent between the two evaluators from the program team (Spearman rho = 0.93, P = 0.03) and fair when these two evaluators' results were compared with the external evaluator's results. The project was undertaken within the framework of the French epidemiological surveillance program EpiNano. This study allowed a first reliability assessment of the EpiNano method. However, to further validate this method a comparison with robust quantitative exposure measurement data is necessary.

  16. Effect of Phonetic Association on Lexis Learning in Natural Language Context: A Comparative Study of English, French and Turkish Words

    ERIC Educational Resources Information Center

    Ebubekir, Bozavli

    2017-01-01

    Mother tongue acquisition starts with words and grammar acquired spontaneously by means of communication, while at school foreign language learning takes place based on grammar. Vocabulary learning is very often neglected or rather it turns into an individual activity. The present study, which is considered to be unique on its own, is to reveal…

  17. Psychometric Properties of Scores on the French and Korean Versions of the Hexaco Personality Inventory. Validity Studies

    ERIC Educational Resources Information Center

    Boies, Kathleen; Yoo, Tae-Yong; Ebacher, Annik; Lee, Kibeom; Ashton, Michael C.

    2004-01-01

    Recent lexical studies of personality structure suggest that there are six independent major dimensions of personality. The HEXACO Personality Inventory (HEXACO-PI), a new questionnaire that measures these six lexically derived personality constructs, was examined in two different cultural contexts using samples of 149 Francophone and 211 Korean…

  18. Computer-Mediated Synchronous and Asynchronous Corrective Feedback Provided by Trainee Teachers to Learners of French: A Preliminary Study

    ERIC Educational Resources Information Center

    Vidal, Julie; Thouësny, Sylvie

    2015-01-01

    In this paper, we investigate whether trainee teachers' practices, with respect to multimodal feedback, differ from current research, and to what extent it may affect students' language development. More specifically, the goal of the present study is threefold: (1) it observes how trainee teachers responded, whether synchronously, asynchronously,…

  19. Comparison of Coaches' Perceptions and Officials Guidance towards Health Promotion in French Sport Clubs: A Mixed Method Study

    ERIC Educational Resources Information Center

    Van Hoye, A.; Heuzé, J.-P.; Larsen, T.; Sarrazin, P.

    2016-01-01

    Despite the call to improve health promotion (HP) in sport clubs in the existing literature, little is known about sport clubs' organizational capacity. Grounded within the setting-based framework, this study compares HP activities and guidance among 10 football clubs. At least three grassroots coaches from each club (n = 68) completed the Health…

  20. Effects of Collaborative Mentoring on the Articulation of Training and Classroom Situations: A Case Study in the French School System

    ERIC Educational Resources Information Center

    Chalies, Sebastien; Bertone, Stefano; Flavier, Eric; Durand, Marc

    2008-01-01

    This study assessed the effects of a collaborative mentoring sequence on the professional development of a preservice teacher (PT). The analysis of data from observation and self-confrontation interviews identified work rules [Wittgenstein, L. (1996). In G. E. M. Anscomb & G. H. Von Wright (Eds.), "Remarques philosophiques"…

  1. The genetic diversity of three peculiar populations descending from the slave trade: Gm study of Noir Marron from French Guiana.

    PubMed

    Brucato, Nicolas; Tortevoye, Patricia; Plancoulaine, Sabine; Guitard, Evelyne; Sanchez-Mazas, Alicia; Larrouy, Georges; Gessain, Antoine; Dugoujon, Jean-Michel

    2009-10-01

    The Noir Marron communities are the direct descendants of African slaves brought to the Guianas during the four centuries (16th to 19th) of the Atlantic slave trade. Among them, three major ethnic groups have been studied: the Aluku, the Ndjuka and the Saramaka. Their history led them to share close relationships with Europeans and Amerindians, as largely documented in their cultural records. The study of Gm polymorphisms of immunoglobulins may help to estimate the amount of gene flow linked to these cultural exchanges. Surprisingly, very low levels of European contribution (2.6%) and Amerindian contribution (1.7%) are detected in the Noir Marron gene pool. On the other hand, an African contribution of 95.7% redraws their origin to West Africa (F(ST) < or = 0.15). This highly preserved African gene pool of the Noir Marron is unique in comparison to other African American populations of Latin America, who are notably more admixed.

  2. Population studies of the filarial vector Aedes polynesiensis (Diptera: Culicidae) in two island settings of French Polynesia.

    PubMed

    Hapairai, Limb K; Sang, Michel A Cheong; Sinkins, Steven P; Bossin, Hervé C

    2013-09-01

    A mark-release-recapture study was conducted to estimate the adult population size, migration, and dispersal patterns of male and female Aedes (Stegomyia) polynesiensis (Marks) in a valley of Moorea, a volcanic island, and a motu (islet) on the atoll of Tetiaroa, two settings typical of the Society Islands. Aedes polynesiensis recapture rate was high for females and low for males. The distribution of Aedes species in the valley was heterogeneous. Marked individuals dispersed to most parts of the motu and over great distances in the valley for some females. The study provides insights into the field dynamics of Ae. polynesiensis populations and confirms that more efficient sampling methods are warranted. There was no evidence of active migration between motus on the atoll, suggesting that Tetiaroa is a suitable site for small-scale initial open releases of Wolbachia incompatible insect technique and other sterile insect technique-like suppression or replacement strategies.

  3. Teaching for Content: Greek Mythology in French.

    ERIC Educational Resources Information Center

    Giauque, Gerald S.

    An intermediate-level university French course in Greek mythology was developed to (1) improve student skills in reading, writing, speaking, and comprehending French, (2) familiarize students with Greek mythology, and (3) prepare students to deal better with allusions to Greek mythology in French literature. The texts used are a French translation…

  4. 21 CFR 169.115 - French dressing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false French dressing. 169.115 Section 169.115 Food and... § 169.115 French dressing. (a) Description. French dressing is the separable liquid food or the... fabricated shall be safe and suitable. French dressing contains not less than 35 percent by weight...

  5. 7 CFR 993.7 - French prunes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false French prunes. 993.7 Section 993.7 Agriculture... Order Regulating Handling Definitions § 993.7 French prunes. French prunes means: (a) Prunes produced from plums of the following varieties of plums: French (Prune d'Agen, Petite Prune d'Agen), Coates...

  6. Walk Score, Transportation Mode Choice, and Walking Among French Adults: A GPS, Accelerometer, and Mobility Survey Study

    PubMed Central

    Duncan, Dustin T.; Méline, Julie; Kestens, Yan; Day, Kristen; Elbel, Brian; Trasande, Leonardo; Chaix, Basile

    2016-01-01

    Background: Few studies have used GPS data to analyze the relationship between Walk Score, transportation choice and walking. Additionally, the influence of Walk Score is understudied using trips rather than individuals as statistical units. The purpose of this study is to examine associations at the trip level between Walk Score, transportation mode choice, and walking among Paris adults who were tracked with GPS receivers and accelerometers in the RECORD GPS Study. Methods: In the RECORD GPS Study, 227 participants were tracked during seven days with GPS receivers and accelerometers. Participants were also surveyed with a GPS-based web mapping application on their activities and transportation modes for all trips (6969 trips). Walk Score, which calculates neighborhood walkability, was assessed for each origin and destination of every trip. Multilevel logistic and linear regression analyses were conducted to estimate associations between Walk Score and walking in the trip or accelerometry-assessed number of steps for each trip, after adjustment for individual/neighborhood characteristics. Results: The mean overall Walk Scores for trip origins were 87.1 (SD = 14.4) and for trip destinations 87.1 (SD = 14.5). In adjusted trip-level associations between Walk Score and walking only in the trip, we found that a walkable neighborhood in the trip origin and trip destination was associated with increased odds of walking in the trip assessed in the survey. The odds of only walking in the trip were 3.48 (95% CI: 2.73 to 4.44) times higher when the Walk Score for the trip origin was “Walker’s Paradise” compared to less walkable neighborhoods (Very/Car-Dependent or Somewhat Walkable), with an identical independent effect of trip destination Walk Score on walking. The number of steps per 10 min (as assessed with accelerometry) was cumulatively higher for trips both originating and ending in walkable neighborhoods (i.e., “Very Walkable”). Conclusions: Walkable

  7. Dialect Effects in Speech Perception: The Role of Vowel Duration in Parisian French and Swiss French

    ERIC Educational Resources Information Center

    Miller, Joanne L.; Mondini, Michele; Grosjean, Francois; Dommergues, Jean-Yves

    2011-01-01

    The current experiments examined how native Parisian French and native Swiss French listeners use vowel duration in perceiving the /[openo]/-/o/ contrast. In both Parisian and Swiss French /o/ is longer than /[openo]/, but the difference is relatively large in Swiss French and quite small in Parisian French. In Experiment 1 we found a parallel…

  8. The role of method of production and resolution of the DEM on slope-units delineation for landslide susceptibility assessment - Ubaye Valley, French Alps case study

    NASA Astrophysics Data System (ADS)

    Schlögel, Romy; Marchesini, Ivan; Alvioli, Massimiliano; Reichenbach, Paola; Rossi, Mauro; Malet, Jean-Philippe

    2016-04-01

    Landslide susceptibility assessment forms the basis of any hazard mapping, which is one of the essential parts of quantitative risk mapping. For the same study area, different susceptibility maps can be achieved depending on the type of susceptibility mapping methods, mapping unit, and scale. In the Ubaye Valley (South French Alps), we investigate the effect of resolution and method of production of the DEM to delineate slope units for landslide susceptibility mapping method. Slope units delineation has been processed using multiple combinations of circular variance and minimum area size values, which are the input parameters for a new software for terrain partitioning. We rely on this method taking into account homogeneity of aspect direction inside each unit and inhomogeneity between different units. We computed slope units delineation for 5, 10 and 25 meters resolution DEM, and investigate statistical distributions of morphometric variables within the different polygons. Then, for each different slope units partitioning, we calibrated a landslide susceptibility model, considering landslide bodies and scarps as a dependent variable (binary response). This work aims to analyse the role of DEM resolution on slope-units delineation for landslide susceptibility assessment. Area Under the Curve of the Receiver Operating Characteristic is investigated for the susceptibility model calculations. In addition, we analysed further the performance of the Logistic Regression Model by looking at the percentage of significant variable in the statistical analyses. Results show that smaller slope units have a better chance of containing a smaller number of thematic and morphometric variables, allowing for an easier classification. Reliability of the models according to the DEM resolution considered as well as scarp area and landslides bodies presence/absence as dependent variable are discussed.

  9. Use of Fibrates Monotherapy in People with Diabetes and High Cardiovascular Risk in Primary Care: A French Nationwide Cohort Study Based on National Administrative Databases

    PubMed Central

    Roussel, Ronan; Chaignot, Christophe; Weill, Alain; Travert, Florence; Hansel, Boris; Marre, Michel; Ricordeau, Philippe; Alla, François; Allemand, Hubert

    2015-01-01

    Background and Aim According to guidelines, diabetic patients with high cardiovascular risk should receive a statin. Despite this consensus, fibrate monotherapy is commonly used in this population. We assessed the frequency and clinical consequences of the use of fibrates for primary prevention in patients with diabetes and high cardiovascular risk. Design Retrospective cohort study based on nationwide data from the medical and administrative databases of French national health insurance systems (07/01/08-12/31/09) with a follow-up of up to 30 months. Methods Lipid-lowering drug-naive diabetic patients initiating fibrate or statin monotherapy were identified. Patients at high cardiovascular risk were then selected: patients with a diagnosis of diabetes and hypertension, and >50 (men) or 60 (women), but with no history of cardiovascular events. The composite endpoint comprised myocardial infarction, stroke, amputation, or death. Results Of the 31,652 patients enrolled, 4,058 (12.8%) received a fibrate. Age- and gender-adjusted annual event rates were 2.42% (fibrates) and 2.21% (statins). The proportionality assumption required for the Cox model was not met for the fibrate/statin variable. A multivariate model including all predictors was therefore calculated by dividing data into two time periods, allowing Hazard Ratios to be calculated before (HR<540) and after 540 days (HR>540) of follow-up. Multivariate analyses showed that fibrates were associated with an increased risk for the endpoint after 540 days: HR<540 = 0.95 (95% CI: 0.78–1.16) and HR>540 = 1.73 (1.28–2.32). Conclusion Fibrate monotherapy is commonly prescribed in diabetic patients with high cardiovascular risk and is associated with poorer outcomes compared to statin therapy. PMID:26398765

  10. Facilitating access to the renal transplant waiting list does not increase the number of transplantations: comparative study of two French regions

    PubMed Central

    Vigneau, Cécile; Laurent, Annelen; Lebbah, Saïd; Le Meur, Nolwenn; Jais, Jean-Philippe; Daugas, Eric; Bayat, Sahar

    2016-01-01

    Background In France, there are important regional disparities of access to the renal transplant waiting list and transplantation. Our objectives were to compare the characteristics of patients with end-stage renal disease (ESRD) of two French regions (Ile-de-France and Bretagne) and to identify determinants of access to the waiting list and subsequent transplantation, with a focus on temporary inactive status (TIS) periods. Methods All 18–80-year-old incident patients who started dialysis in Ile-de-France or Bretagne between 2006 and 2009 were included (n = 6160). Associations between patients' characteristics and placement on the waiting list or transplantation were assessed using a Fine and Gray model to take into account the competing risk of death and living donor transplantation. Results At the end of the follow-up (31 December 2013), more patients had undergone transplantation in Bretagne than in Ile-de-France (30 versus 27%), although the percentage of waitlisted patients was higher in Ile-de-France than in Bretagne (47 versus 33%). More patients were on TIS and with a longer median TIS duration in Ile-de-France. Independent of age and clinical characteristics, patients in Bretagne were less likely to be waitlisted than those in Ile-de-France [subdistribution hazard ratio 0.77 (95% confidence interval 0.7–0.9)]. After waitlisting, patients in Bretagne were four times more likely to be transplanted. Conclusions Our study highlights clinical practice differences in Bretagne and Ile-de-France and shows that facilitating access to the waiting list is not sufficient to improve access to renal transplantation, which also depends on organ availability. PMID:27994866

  11. Impact of the 2008-2012 French Alzheimer Plan on the use of cerebrospinal fluid biomarkers in research memory center: the PLM Study.

    PubMed

    Gabelle, Audrey; Dumurgier, Julien; Vercruysse, Olivier; Paquet, Claire; Bombois, Stéphanie; Laplanche, Jean-Louis; Peoc'h, Katell; Schraen, Susanna; Buée, Luc; Pasquier, Florence; Hugon, Jacques; Touchon, Jacques; Lehmann, Sylvain

    2013-01-01

    The French Alzheimer's Disease Plan aims, in an unprecedented national effort, to develop research, promote optimal diagnosis, and take better care of patients. In order to evaluate the clinical interest and use of cerebrospinal fluid (CSF) biomarkers, a data-sharing project, the PLM (Paris-North, Lille and Montpellier) study has emerged through collaboration between these memory centers, already involved in this field. The revised Alzheimer's disease (AD) diagnosis criteria include CSF biomarkers, but little is known about their use in routine clinical practice. To evaluate their interest and diagnostic accuracy in routine AD diagnosis, a cohort of 677 patients from Montpellier was first analyzed. The results were then validated through the analysis of a second cohort of 638 patients from Lille and Paris-Nord. Diagnoses of AD and other dementias were established by multidisciplinary expert teams, based on neuropsychological exams and structural brain imaging, blinded from CSF results. CSF amyloid-β, tau, and p-tau concentrations were measured for all patients. Receiver-operating characteristic curves were used to define cut-offs and evaluate the ability of each biomarker to discriminate AD from other diagnoses. We showed that p-tau outperformed other biomarkers for discriminating AD from non-AD patients and presents a clear clinical interest. The other biomarkers also showed relevant variations especially when the differential AD diagnoses were taken into account. Altogether we could demonstrate in both mono-centric and multi-centric cohorts from memory clinics the capacity of CSF biomarkers to discriminate AD from non-AD patients in clinical routine with a high sensitivity and specificity.

  12. A lymph node ratio of 10% is predictive of survival in stage III colon cancer: a French regional study.

    PubMed

    Sabbagh, Charles; Mauvais, François; Cosse, Cyril; Rebibo, Lionel; Joly, Jean-Paul; Dromer, Didier; Aubert, Christine; Carton, Sophie; Dron, Bernard; Dadamessi, Innocenti; Maes, Bernard; Perrier, Guillaume; Manaouil, David; Fontaine, Jean-François; Gozy, Michel; Panis, Xavier; Foncelle, Pierre Henri; de Fresnoy, Hugues; Leroux, Fabien; Vaneslander, Pierre; Ghighi, Caroline; Regimbeau, Jean-Marc

    2014-01-01

    Lymph node ratio (LNR) (positive lymph nodes/sampled lymph nodes) is predictive of survival in colon cancer. The aim of the present study was to validate the LNR as a prognostic factor and to determine the optimum LNR cutoff for distinguishing between "good prognosis" and "poor prognosis" colon cancer patients. From January 2003 to December 2007, patients with TNM stage III colon cancer operated on with at least of 3 years of follow-up and not lost to follow-up were included in this retrospective study. The two primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS) as a function of the LNR groups and the cutoff. One hundred seventy-eight patients were included. There was no correlation between the LNR group and 3-year OS (P=0.06) and a significant correlation between the LNR group and 3-year DFS (P=0.03). The optimal LNR cutoff of 10% was significantly correlated with 3-year OS (P=0.02) and DFS (P=0.02). The LNR was not an accurate prognostic factor when fewer than 12 lymph nodes were sampled. Clarification and simplification of the LNR classification are prerequisites for use of this system in randomized control trials. An LNR of 10% appears to be the optimal cutoff.

  13. A Lymph Node Ratio of 10% Is Predictive of Survival in Stage III Colon Cancer: A French Regional Study

    PubMed Central

    Sabbagh, Charles; Mauvais, François; Cosse, Cyril; Rebibo, Lionel; Joly, Jean-Paul; Dromer, Didier; Aubert, Christine; Carton, Sophie; Dron, Bernard; Dadamessi, Innocenti; Maes, Bernard; Perrier, Guillaume; Manaouil, David; Fontaine, Jean-François; Gozy, Michel; Panis, Xavier; Foncelle, Pierre Henri; de Fresnoy, Hugues; Leroux, Fabien; Vaneslander, Pierre; Ghighi, Caroline; Regimbeau, Jean-Marc

    2014-01-01

    Lymph node ratio (LNR) (positive lymph nodes/sampled lymph nodes) is predictive of survival in colon cancer. The aim of the present study was to validate the LNR as a prognostic factor and to determine the optimum LNR cutoff for distinguishing between “good prognosis” and “poor prognosis” colon cancer patients. From January 2003 to December 2007, patients with TNM stage III colon cancer operated on with at least of 3 years of follow-up and not lost to follow-up were included in this retrospective study. The two primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS) as a function of the LNR groups and the cutoff. One hundred seventy-eight patients were included. There was no correlation between the LNR group and 3-year OS (P = 0.06) and a significant correlation between the LNR group and 3-year DFS (P = 0.03). The optimal LNR cutoff of 10% was significantly correlated with 3-year OS (P = 0.02) and DFS (P = 0.02). The LNR was not an accurate prognostic factor when fewer than 12 lymph nodes were sampled. Clarification and simplification of the LNR classification are prerequisites for use of this system in randomized control trials. An LNR of 10% appears to be the optimal cutoff. PMID:25058763

  14. Proteins, dietary acid load, and calcium and risk of postmenopausal fractures in the E3N French women prospective study

    PubMed Central

    Dargent-Molina, Patricia; Sabia, Sèverine; Touvier, Mathilde; Kesse, Emmanuelle; Bréart, Gérard; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie-Christine

    2008-01-01

    Introduction Excess dietary proteins and “acid ash” diets have been suspected to increase the risk of osteoporosis, but experimental and epidemiological evidence is mixed. We aimed to determine whether the association between protein intake and the overall acid-base equilibrium of the diet (as renal net acid excretion (RNAE) estimate) and fracture risk vary according to calcium intake. Materials and Methods During an average of 8.37 (± 1.73) years of follow up, 2408 women reported a fracture (excluding high-impact trauma) among 36,217 postmenopausal women from the E3N prospective study. We used Cox regression models to study the interaction between calcium and, respectively, proteins and RNAE, from the 1993 dietary questionnaire, for fracture risk determination, adjusting for potential confounders. Results There was no overall association between fracture risk and total protein or RNAE. However, in the lowest quartile of calcium (< 400 mg/1000 kcal), high protein intake was associated with a significant increased fracture risk (RR = 1.51 for highest versus lowest quartile; 95% CI 1.17–1.94). An increasing fracture risk with increasing animal protein intake was also observed (p trend <0.0001). A similar pattern of interaction for fracture risk was observed between RNAE and calcium. Conclusions In this Western population of post-menopausal women with normal to high protein intake and fairly high calcium intake, there was no overall association between total protein or RNAE and fracture risk. However, there was some evidence that high protein – high acid ash diets were associated with an increased risk of fracture when calcium intake was low (< 400 mg/1000 kcal). PMID:18665794

  15. Reproducibility of parameters for assessment of diabetic neuropathy. The French Group for Research and Study of Diabetic Neuropathy.

    PubMed

    Valensi, P; Attali, J R; Gagant, S

    1993-12-01

    This study evaluated the reproducibility of nerve function assessment in a group of 132 diabetic patients with moderate peripheral polyneuropathy. Patients were investigated at the beginning and the end of the run-in period (a 1-month placebo period) of a multicentre trial of an aldose-reductase inhibitor (Ponalrestat). Reproducibility was evaluated by performing four types of tests: quantitative visual scales of symptoms, quantitative sensory assessment (vibration perception thresholds in medial malleolus and great toe, foot thermal perception threshold to hot and cold), electrophysiological investigations on the dominant side (conduction velocities and potential amplitudes of sensory and median motor nerve, sural and peroneal nerves, amplitudes of F waves of median motor and peroneal nerves) and cardiac autonomic tests (Valsalva, deep-breathing, lying-to-standing). Reproducibility was poor for symptoms, thermal sensitivity, and potential amplitudes. It was satisfactory (total coefficient of variation < 50%) for all the other parameters and even very good (total variation coefficient < 26%, intra-subject variation factors corresponding to < 56% of total variance) for velocities of sensory and median motor and peroneal nerves, the amplitudes of F waves and the three autonomic tests. For most of the parameters total variance was mainly related to inter-subject variability. However, inter-subject variability for the three cardiac autonomic tests was very low and at least one cardiac autonomic test was altered in all the patients. Inter-centre variability was low for all the parameters, except for action potential amplitudes and for F wave velocity of the median motor nerve. This study suggests those parameters that are appropriate for the assessment of diabetic neuropathy and for therapeutic trials.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Familial history of cancer and childhood acute leukemia: a French population-based case-control study

    PubMed Central

    Ripert, Mahaut; Menegaux, Florence; Perel, Yves; Méchinaud, Françoise; Plouvier, Emmanuel; Gandemer, Virginie; Lutz, Patrick; Vannier, Jean-Pierre; Lamagnére, Jean-Pierre; Margueritte, Geneviève; Boutard, Patrick; Robert, Alain; Armari-Alla, Corinne; Munzer, Martine; Millot, Frédéric; de Lumley, Lionel; Berthou, Christian; Rialland, Xavier; Pautard, Brigitte; Clavel, Jacqueline

    2007-01-01

    Objective A case-control study was conducted to investigate the role of a familial history of cancer in the etiology of childhood acute leukemia (AL). Methods The history of cancer in the relatives of 472 cases was compared to that of 567 population-based controls. Recruitment was frequency matched on age, gender and region. The familial history of cancer in each child’s relatives was reported by the mother in response to a standardized self-administered questionnaire. Results A familial history of solid tumor in first- or second-degree relatives was associated with an increased risk of ALL (OR=1.6 [1.2–2.1]), while a familial history of hematopoietic malignancies in first- or second-degree relatives was associated with an increased risk of AML (OR=4.3 [1.4–13]). The ORs for the histories of cancer increased with the number of relatives with cancer (OR=1.5 [1.1–2.0] for one relative and OR=2.3 [1.3–3.8] for two relatives or more; ptrend<0.0001). Significant associations between childhood AL and familial history of genital cancers and brain tumor were also observed (OR=2.7 [1.2–5.8], OR=10.7 [1.3–86], respectively). Conclusion This study supports the hypothesis that a familial history of cancer may play a role in the etiology of childhood acute leukemia. It also evidences some specific associations that require further investigation. PMID:17923819

  17. Feudalism and the French Revolution.

    ERIC Educational Resources Information Center

    Kaiser, Thomas E.

    1979-01-01

    Reviews and questions the traditional established interpretation that the French Revolution was about feudalism. Concludes that revisionist historians have cast doubt upon the orthodox theory but that they have not supplied an alternative explanation. (Author/DB)

  18. Cause of death in patients with atrial fibrillation admitted to French hospitals in 2012: a nationwide database study

    PubMed Central

    Fauchier, Laurent; Samson, Adeline; Chaize, Gwendoline; Gaudin, Anne-Françoise; Vainchtock, Alexandre; Bailly, Cécile; Cotté, Francois-Emery

    2015-01-01

    Objective Most patients with atrial fibrillation (AF) have risk factors and coexisting conditions that increase their mortality risk. We performed a cause-of-death analysis to identify predictors of mortality in hospitalised patients with AF in France. Methods and results In this retrospective, population-based cross-sectional study, the Programme de médicalisation des systèmes d'information was used to identify 533 044 adults with a diagnosis of AF or atrial flutter hospitalised for any reason in France from January through December 2012. Stepwise multivariable analyses were performed to identify determinants of mortality. The mean age was 78.0±11.4 years, 47.1% were women, and the mean CHA2DS2-VASc score was 4.0±1.8. During hospitalisation, 9.4% (n=50 165) of the patients died, 34% due to a cardiovascular event, most often heart failure (16.6%), stroke/transient ischaemic attack/systemic embolism (9.8%) or vascular or ischaemic disease (4.0%). The strongest predictors of overall death were age ≥75 years (OR 2.57, 95% CI 2.47 to 2.68), renal failure (OR 1.85, 95% CI 1.81 to 1.89), cancer (OR 1.81, 95% CI 1.78 to 1.85) and lung disease (OR 1.58, 95% CI 1.55 to 1.62). Conclusions Cardiovascular events were the most common cause of death, occurring in one-third of patients, in this comprehensive study of hospitalised patients with AF. Despite the high risk of stroke in this population, only 10% died from stroke/transient ischaemic attack/systemic embolism. The strongest predictors of overall death were non-cardiovascular. Physicians should be encouraged to focus on preventable serious and disabling cardiovascular events (such as stroke) as well as on potentially fatal non-cardiovascular comorbidities. PMID:26688739

  19. Comparison of coaches' perceptions and officials guidance towards health promotion in French sport clubs: a mixed method study.

    PubMed

    Van Hoye, A; Heuzé, J-P; Larsen, T; Sarrazin, P

    2016-06-01

    Despite the call to improve health promotion (HP) in sport clubs in the existing literature, little is known about sport clubs' organizational capacity. Grounded within the setting-based framework, this study compares HP activities and guidance among 10 football clubs. At least three grassroots coaches from each club (n = 68) completed the Health Promoting Sports Clubs scale to assess their perceptions of HP; an official (n = 10) was interviewed about club's activities and official's guidance provided to coaches. A concurrent embedded design with quantitative results guiding the qualitative analysis was used. Despite no significant differences regarding coaches' perceptions of HP between the 10 sport clubs, except for the policy dimension, officials' interviews revealed some contradictions. Sport participation was recognized as automatically promoting HP, meaning that sport practice entails many benefits, without questioning the nature of the activities. HP was considered as a secondary aim in regard to sport performance, leading to the lack of written policies, partnerships and sporadic HP activities. Future interventions should consider: (i) the creation of required policy and long-term vision; (ii) the link between HP and sport performance; (iii) the rootedness of sport clubs within their community and (iv) guidelines towards HP from sport federations.

  20. Primary bone diffuse large B-cell lymphoma: a retrospective evaluation on 76 cases from French institutional and LYSA studies.

    PubMed

    Pilorge, Sylvain; Harel, Stephanie; Ribrag, Vincent; Larousserie, Frédérique; Willems, Lise; Franchi, Patricia; Legoff, Marielle; Biau, David; Anract, Philippe; Roux, Christian; Blanc-Autran, Estelle; Delarue, Richard; Gisselbrecht, Christian; Ketterer, Nicolas; Recher, Christian; Bonnet, Christophe; Peyrade, Frederic; Haioun, Corinne; Tilly, Hervé; Salles, Gilles; Brice, Pauline; Bouscary, Didier; Deau, Bénédicte; Tamburini, Jerome

    2016-12-01

    Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare DLBCL location variant. We treated 76 PB-DLBCL patients by immuno-chemotherapy, resulting in an 84% sustained complete remission rate and a 78.9% survival over a 4.7-year median follow-up period. Ann Arbor stage IV and high age-adjusted international prognostic index were predictive of adverse outcome in univariate analysis. In multivariate analysis using a Cox model, only aa-IPI predicted long-term survival. While based on a limited number of cases, we suggested that radiotherapy may be useful as a consolidation modality in PB-DLBCL. We also suggested that positron emission tomography/CT scan should be interpreted with caution due to a persistent [18F]fluorodeoxyglucose [18FDG] uptake of bone lesions even after remission in some in PB-DLBCL patients. Our study based on a homogeneous cohort of PB-DLBCL patients confirmed the favorable outcome of this DLBCL variant and support the implementation of prospective clinical trials in this disease.

  1. Association between reported sleep need and sleepiness at the wheel: comparative study on French highways between 1996 and 2011

    PubMed Central

    Quera-Salva, M A; Sauvagnac-Quera, R; Sagaspe, P; Taillard, J; Contrand, B; Micoulaud, J A; Lagarde, E; Barbot, F; Philip, P

    2016-01-01

    Objective To investigate the evolution over 15 years of sleep schedules, sleepiness at the wheel and driving risk among highway drivers. Methods Comparative survey including questions on usual sleep schedules and before the trip, sleepiness at the wheel, the Epworth sleepiness scale, Basic Nordic Sleep Questionnaire (BNSQ) and a travel questionnaire. Results 80% of drivers stopped by the highway patrol agreed to participate in both studies with a total of 3545 drivers in 2011 and 2196 drivers in 1996 interviewed. After standardisation based on sex, age and mean annual driving distance, drivers in 2011 reported shorter sleep time on week days (p<0.0001), and week-ends (p<0.0001) and shorter optimal sleep time (p<0.0001) compared to 1996 drivers. There were more drivers sleepy at the wheel in 2011 than in 1996 (p<0.0001) and 2.5 times more drivers in 2011 than in 1996 had an Epworth sleepiness score >15 indicating severe sleepiness. Conclusions Even if drivers in 2011 reported good sleep hygiene prior to a highway journey, drivers have reduced their mean weekly sleep duration over 15 years and have a higher risk of sleepiness at the wheel. Sleep hygiene for automobile drivers remains an important concept to address. PMID:28003284

  2. Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study

    PubMed Central

    Etienne-Grimaldi, M-C; Mahamat, A; Chazal, M; Laurent-Puig, P; Olschwang, S; Gaub, M-P; Formento, J-L; Formento, P; Sudaka, A; Boige, V; Abderrahim-Ferkoune, A; Benchimol, D; André, T; Houry, S; Faucheron, J-L; Letoublon, C; Gilly, F-N; Delpero, J-R; Lasser, P; Pradere, B; Pezet, D; Penault-Llorca, F; Milano, G

    2014-01-01

    Background: To test the prognostic value of tumour protein and genetic markers in colorectal cancer (CRC) and examine whether deficient mismatch repair (dMMR) tumours had a distinct profile relative to proficient mismatch repair (pMMR) tumours. Methods: This prospective multicentric study involved 251 stage I–III CRC patients. Analysed biomarkers were EGFR (binding assay), VEGFA, thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) expressions, MMR status, mutations of KRAS (codons 12–13), BRAF (V600E), PIK3CA (exons 9 and 20), APC (exon 15) and P53 (exons 4–9), CpG island methylation phenotype status, ploidy, S-phase, LOH. Results: The only significant predictor of relapse-free survival (RFS) was tumour staging. Analyses restricted to stage III showed a trend towards a shorter RFS in KRAS-mutated (P=0.005), BRAF wt (P=0.009) and pMMR tumours (P=0.036). Deficient mismatch repair tumours significantly demonstrated higher TS (median 3.1 vs 1.4) and TP (median 5.8 vs 3.5) expression relative to pMMR (P<0.001) and show higher DPD expression (median 14.9 vs 7.9, P=0.027) and EGFR content (median 69 vs 38, P=0.037) relative to pMMR. Conclusions: Present data suggesting that both TS and DPD are overexpressed in dMMR tumours as compared with pMMR tumours provide a strong rationale that may explain the resistance of dMMR tumours to 5FU-based therapy. PMID:24800948

  3. Are managers' and the general public's perceptions of risk communication needs in line? A French alpine valley case study

    NASA Astrophysics Data System (ADS)

    Charrière, Marie; Sprague, Teresa; Bogaard, Thom; Greiving, Stefan; Malet, Jean-Philippe; Mostert, Erik

    2013-04-01

    Risk communication is a crucial element of risk management. It contributes to social capacity building by influencing the knowledge, attitude, behavior, psychology, as well as social and organizational aspects1,2. It is globally recognized that effective risk communication should address needs and requirements of targeted audiences, especially those of the public. This study compares needs and requirements related to risk communication as seen by the risk managers, with the needs and requirements as expressed by the general public. Two surveys were conducted in a mountainous region facing multi-hazards, the Ubaye valley (France). The first survey, conducted within the context of the Marie Curie Research and Training Network 'Mountain Risk', was addressed to the local community. It aimed at gathering perceptions, needs and requirements of the general public (344 respondents) on risk communication3. The second survey, conducted in the context of the Marie Curie Initial Training Network 'CHANGES', targeted risk managers (16 stakeholders of the authorities, technical services and emergency units) at both the local and the regional scale to evaluate their perceptions regarding risk communication with the general public. The needs and requirements were analyzed with respect to several dimensions: 1) the information provided to the public, 2) the legal requirements for communication, 3) the level of trust the population has in risk managers, 4) insights on awareness and preparedness, and 5) information on the media used in past communication efforts. Results of the analysis concerning the last dimension reveal that, while the general public mentioned press, official reports and technical reports as the top three media by which they received information, the risk managers cited the press but in contrast also selected radio and television. Other results indicate that a potential mismatch exists as more than 80% of the respondents of the population find all listed topics

  4. French perspectives on psychiatric classification

    PubMed Central

    Crocq, Marc-Antoine

    2015-01-01

    This article reviews the role of the French schools in the development of psychiatric nosology. Boissier de Sauvages published the first French treatise on medical nosology in 1763. Until the 1880s, French schools held a pre-eminent position in the development of psychiatric concepts. From the 1880s until World War I, German-speaking schools exerted the most influence, featuring the work of major figures such as Emil Kraepelin and Eugen Bleuler. French schools were probably hampered by excessive administrative and cultural centralization. Between the 1880s and the 1930s, French schools developed diagnostic categories that set them apart from international classifications. The main examples are Bouffée Délirante, and the complex set of chronic delusional psychoses (CDPs), including chronic hallucinatory psychosis. CDPs were distinguished from schizophrenia by the lack of cognitive deterioration during evolution. Modern French psychiatry is now coming into line with international classification, such as DSM-5 and the upcoming ICD-11. PMID:25987863

  5. French fireball network FRIPON

    NASA Astrophysics Data System (ADS)

    Colas, F.; Zanda, B.; Vaubaillon, J.; Bouley, S.; Marmo, C.; Audureau, Y.; Kwon, M. K.; Rault, J.-L.; Caminade, S.; Vernazza, P.; Gattacceca, J.; Birlan, M.; Maquet, L.; Egal, A.; Rotaru, M.; Birnbaum, C.; Cochard, F.; Thizy, O.

    2015-01-01

    FRIPON (Fireball Recovery and Interplanetary Observation Network) was recently founded by ANR (Agence Nationale de la Recherche), its aim being to connect meteoritical science with asteroidal and cometary sciences, in order to better understand our solar system formation and evolution. The main idea is to cover all the French territory to collect a large number of meteorites (one or two per year) with an accurate orbit determination, allowing to pinpoint possible parent bodies. 100 all-sky cameras will be installed at the end of 2015, creating a dense network with an average distance of 100 km between the stations. To maximize the accuracy of the orbit determination, we will mix our optical data with radar data from the GRAVES transmitter received by 25 stations (Rault et al., 2015). As the network installation and the creation of research teams for meteorites involves many persons, at least many more than our small team of professionals, we will develop a participative science network for amateurs called Vigie-Ciel (Zanda et al., 2015). It will be possible to simply use our data, participate in research campaigns or even add cameras to the FRIPON network.

  6. Seeking health- and nutrition-related information on the Internet in a large population of French adults: results of the NutriNet-Santé study.

    PubMed

    Fassier, Philippine; Chhim, Anne-Sophie; Andreeva, Valentina A; Hercberg, Serge; Latino-Martel, Paule; Pouchieu, Camille; Touvier, Mathilde

    2016-06-01

    The Internet has become a major source of health and nutrition information. Little is known about the type of consulted websites (institutional v. non-institutional) and the tendency to discuss with a healthcare professional (HCP) the information found on the Internet. The aim of this cross-sectional study was to investigate health- and nutrition-related Internet use in a large French population-based study. Data were collected in 2013 using self-administered, web-based questionnaires from 42 113 participants of the NutriNet-Santé study (mean age=51·2 years, 76 % women). Unconditional multivariate logistic regression analyses and χ 2 tests were used for comparisons. In total, 85·1 % of the subjects used the Internet to search for health and/or nutrition information, and 23·6 % used the Internet to read or post messages on health/nutrition forums. Only 16·0 % discussed with a HCP the information found online. This proportion was lower in subjects with lower educational level (OR 0·77; 95 % CI 0·72, 0·82) and lower computer skills (OR 0·70; 95 % CI 0·65, 0·76). In total, 8038 health/nutrition websites were cited, with institutional websites representing only 12·9 % of that number. Only one institutional website was present in the top 10. Older subjects (OR 1·49; 95 % CI 1·28-1·74), those with lower educational level (OR 2·08; 95 % CI 1·75, 2·50) and lower nutritional knowledge (OR 1·33; 1·12, 1·59) were more likely to cite non-institutional websites. This large population-based study showed that institutional websites were infrequently accessed and that a few participants discussed the information found online with their HCP. This particular trend was especially visible among individuals who were more vulnerable regarding misleading information. This supports the need to increase awareness of high-quality websites providing reliable health/nutrition information.

  7. Long-term efficacy and toxicity of abacavir/lamivudine/nevirapine compared to the most prescribed ARV regimens before 2013 in a French Nationwide Cohort Study.

    PubMed

    de Boissieu, Paul; Dramé, Moustapha; Raffi, François; Cabie, André; Poizot-Martin, Isabelle; Cotte, Laurent; Garraffo, Rodolphe; Delobel, Pierre; Huleux, Thomas; Rey, David; Bani-Sadr, Firouzé

    2016-09-01

    Data on the long-term efficacy and safety of abacavir/lamivudine (ABC/3TC) and nevirapine (NVP) are scarce. This combination has the advantage of simplifying treatment and improving long-term tolerance. The aim of this study was to compare the rate of any discontinuation of antiretroviral (ARV) regimen because of virologic failure (VF), and/or adverse drug reaction (ADR) among patients receiving stable ARV regimens for at least 6 months.ABC/3TC/NVP was compared to ABC/3TC with either ritonavir-boosted darunavir (DRV/r) or ritonavir-boosted atazanavir (ATV/r), unboosted ATV, or tenofovir/emtricitabine (TDF/FTC) with either one of the following: ATV/r, unboosted ATV, DRV/r, efavirenz (EFV), or NVP, in the French prospective multicenter Dat'AIDS cohort.The study enrolled 16,511 patients treated with following ARV regimens: ABC/3TC/NVP (n = 1089), TDF/FTC/NVP (n = 1542), ABC/3TC/DRV/r (n = 1065), ABC/3TC/ATV/r (n = 1847), ABC/3TC/ATV (n = 563), TDF/FTC/ATV/r (n = 3519), TDF/FTC/DRV/r (n = 2767), TDF/FTC/ATV (n = 419), and TDF/FTC/EFV (n = 3700). Mean follow-up was 36 ± 24 months. Patients treated with ABC/3TC/NVP received this regimen as a switch regimen in 97% of cases. By multivariable analysis, the risk of treatment discontinuation due to VF was similar between ABC/3TC/NVP and other ARV regimens, except for TDF/FTC/ATV and ABC/3TC/ATV, which were associated with a higher risk of treatment interruption due to VF (hazard ratio [HR] 1.99; 95% confidence interval [CI] 1.29-3.06 and HR 2.19; 95% CI 1.51-3.18, respectively). Treatment discontinuation due to ADR was lowest with the ABC/3TC/NVP regimen. Other ARV regimens were associated with a 1.80- to 3.19-fold increase in the risk of treatment discontinuation due to ADR (P < 0.0001 for all comparisons).ABC/3TC/NVP as a simplification regimen is a long-term effective regimen with lower discontinuation due to long-term toxicity compared with other standard ARV regimens.

  8. How much sugar do consumers add to plain yogurts? Insights from a study examining French consumer behavior and self-reported habits.

    PubMed

    Saint-Eve, Anne; Leclercq, Hélène; Berthelo, Sébastien; Saulnier, Benjamin; Oettgen, Walther; Delarue, Julien

    2016-04-01

    In France, 50% of consumers sweeten plain yogurts prior to consumption. This study measured how much sugar consumers added under contextualized testing conditions. Participants (199 French adults who regularly consume plain yogurt adding sugar) were given a plain yogurt (125 g) at the end of a full meal and were allowed to sweeten it with their usual sweetener (caster sugar, honey, or jam). The quantities added were measured indirectly by weighing the sweetener containers before and after use; they were then converted into equivalent quantities of sucrose, or "added sugar." Participants were asked to describe their relative hunger, thirst, and liking for plain yogurt and to estimate the quantity of sweetener they had added. On average, participants added 13.6 g of sugar to their yogurts, which is higher than the 10.2 g of sugar contained in pre-sweetened commercial yogurts (125 g). More sugar was added when subjects used jam (24.4 g/yogurt, n = 36) as opposed to caster sugar (11.0 g/yogurt, n = 134) or honey (12.1 g/yogurt, n = 29). Age, socio-professional category, and BMI had a significant influence on added-sugar quantity. Based on behavior and attitude, participants could be separated into three evenly sized groups: "low sugar users" (n = 67, median = 6.1 g/yogurt), who tended to control their food intake, "medium sugar users" (n = 66, median = 11.4 g/yogurt), and "heavy sugar users" (n = 66, median = 19.9 g/yogurt) who sought immediate satisfaction. To our knowledge, this study is the first to provide robust data on the amount of sugar consumers add to plain yogurts in contextualized conditions (self preparation during a real meal). Our findings show that consumers underestimated by half the quantity of sweetener they added.

  9. General practitioner management related to skin cancer prevention and screening during standard medical encounters: a French cross-sectional study based on the International Classification of Primary Care

    PubMed Central

    Rat, Cédric; Houd, Sara; Gaultier, Aurélie; Grimault, Charlotte; Quereux, Gaelle; Mercier, Alain; Letrilliart, Laurent; Dreno, Brigitte; Nguyen, Jean Michel

    2017-01-01

    Objective The aim of this study was to assess general practitioner (GP) management practices related to skin cancer prevention and screening during standard medical encounters. Setting Data on medical encounters addressing skin cancer issues were obtained from a French database containing information from 17 019 standard primary care consultations. Participants Data were collected between December 2011 and April 2012 by 54 trainees who reported the regular practice of 128 GPs using the International Classification of Primary Care. Outcome measures Reasons for encounters and the following care processes were recorded: counselling, clinical examinations and referral to a specialist. Medical encounters addressing skin cancer issues were compared with medical encounters that addressed other health problems using a multivariate analysis. Results Only 0.7% of medical encounters addressed skin cancer issues. When patients did require management of a skin cancer-related issue, this was more likely initiated by the doctor than the patient (70.7% vs 29.3%; p<0.001). Compared with medical encounters addressing other health problems, encounters that addressed skin cancer problems required more tasks (3.7 vs 2.5; p<0.001) and lasted 1 min and 20 s longer (p=0.003). GPs were less involved in clinical examinations (67.5% vs 97.1%; p<0.001), both complete (7.3% vs 22.3%, p<0.001) and partial examinations (60.2% vs 74.9%), and were less involved in counselling (5.7% vs 16.9%; p<0.001). Patients presenting skin cancer issues were referred to a specialist more often than patients consulting for other health problems (39.0% vs 12.1%; p<0.001). GPs performed a biopsy in 6.7% of all skin cancer-related encounters. Conclusions This study demonstrates discrepancies between the high prevalence of skin cancer and the low rate of medical encounters addressing these issues in general practice. Our findings should be followed by qualitative interviews to better understand the observed

  10. The Learning of Sociolinguistic Variation by Advanced FSL Learners: The Case of Nous versus "on" in Immersion French

    ERIC Educational Resources Information Center

    Rehner, Katherine; Mougeon, Raymond; Nadasdi, Terry

    2003-01-01

    This paper synthesizes research on the acquisition of linguistic variation by learners of French as a second language--an overview that, to our knowledge, is the first of its kind. It also presents a case study on French immersion students' acquisition of the pronouns "nous" and "on" "we," an alternation in many varieties of spoken French. The…

  11. Effect of Constructivist Teaching Method on Students' Achievement in French Listening Comprehension in Owerri North LGA of Imo State, Nigeria

    ERIC Educational Resources Information Center

    Uwalaka, A. J.; Offorma, G. C.

    2015-01-01

    The study investigated the effect of constructivist teaching method on students' achievement in French listening comprehension in Owerri North Local Government Area of Imo State, Nigeria. Achievement in French listening comprehension over the years has been discouraging. The conventional method of teaching French Language has not improved the…

  12. Gaining a better understanding of respiratory health inequalities among cities: An ecological case study on elderly males in the larger French cities

    PubMed Central

    2013-01-01

    Background In recent years, there have been a growing number of studies on spatial inequalities in health covering a variety of scales, from small areas to metropolitan areas or regions, and for various health outcomes. However, few investigations have compared health status between cities with a view to gaining a better understanding of the relationships between such inequalities and the social, economic and physical characteristics. This paper focuses on disparities in respiratory health among the 55 largest French cities. The aim is to explore the relationships between inter-urban health patterns, city characteristics and regional context, and to determine how far a city’s health status relates to the features observed on different geographical scales. Methods We used health data describing hospitalizations for Chronic Obstructive Pulmonary Disease (COPD) as a proxy for respiratory health, and the total number of hospitalizations (overall) as a proxy for general health. This last indicator was used as a benchmark. A large set of indicators relating to socioeconomic, physical and amenity aspects of the cities (urban units) was also constructed. Data were analyzed using linear correlations and multiple linear regression models. Results The results suggest that socioeconomic characteristics are major discriminators for inequalities in respiratory health status among urban units. Indeed, once combined to socioeconomic characteristics, only a climate indicator remained significant among the physical indicators. It appeared that the pollution indicators which were significantly correlated with COPD hospitalization rates loosed significance when associated to the socio-economic indicators in a multiple regression. The analysis showed that among the socio-economic indicators, an employment indicator derived at the regional scale, and two indicators reflecting the unequal intra-urban spatial distribution of population according to their education, were the most

  13. Studying relationships between environment and malaria incidence in Camopi (French Guiana) through the objective selection of buffer-based landscape characterisations

    PubMed Central

    2011-01-01

    Background Malaria remains a major health problem in French Guiana, with a mean of 3800 cases each year. A previous study in Camopi, an Amerindian village on the Oyapock River, highlighted the major contribution of environmental features to the incidence of malaria attacks. We propose a method for the objective selection of the best multivariate peridomestic landscape characterisation that maximises the chances of identifying relationships between environmental features and malaria incidence, statistically significant and meaningful from an epidemiological point of view. Methods A land-cover map, the hydrological network and the geolocalised inhabited houses were used to characterise the peridomestic landscape in eleven discoid buffers with radii of 50, 100, 200, 300, 400, 500, 600, 700, 800, 900 and 1000 metres. Buffer-based landscape characterisations were first compared in terms of their capacity to discriminate between sites within the geographic space and of their effective multidimensionality in variable space. The Akaike information criterion (AIC) was then used to select the landscape model best explaining the incidences of P. vivax and P. falciparum malaria. Finally, we calculated Pearson correlation coefficients for the relationships between environmental variables and malaria incidence, by species, for the more relevant buffers. Results The optimal buffers for environmental characterisation had radii of 100 m around houses for P. vivax and 400 m around houses for P. falciparum. The incidence of P. falciparum malaria seemed to be more strongly linked to environmental features than that of P. vivax malaria, within these buffers. The incidence of P. falciparum malaria in children was strongly correlated with proportions of bare soil (r = -0.69), land under high vegetation (r = 0.68) and primary forest (r = 0.54), landscape division (r = 0.48) and the number of inhabited houses (r = -0.60). The incidence of P. vivax malaria was associated only with landscape

  14. Epidemiological, virological and clinical characteristics of HBV infection in 223 HIV co-infected patients: a French multi-centre collaborative study

    PubMed Central

    2013-01-01

    Background Chronic hepatitis B (CHB) is a clinical concern in human immunodeficiency virus (HIV)-infected individuals due to substantial prevalence, difficulties to treat, and severe liver disease outcome. A large nationwide cross-sectional multicentre analysis of HIV-HBV co-infected patients was designed to describe and identify parameters associated with virological and clinical outcome of CHB in HIV-infected individuals with detectable HBV viremia. Methods A multicenter collaborative cross-sectional study was launched in 19 French University hospitals distributed through the country. From January to December 2007, HBV load, genotype, clinical and epidemiological characteristics of 223 HBV-HIV co-infected patients with an HBV replication over 1000 IU/mL were investigated. Results Patients were mostly male (82%, mean age 42 years). Genotype distribution (A 52%; E 23.3%; D 16.1%) was linked to risk factors, geographic origin, and co-infection with other hepatitis viruses. This genotypic pattern highlights divergent contamination event timelines by HIV and HBV viruses. Most patients (74.7%) under antiretroviral treatment were receiving a drug with anti-HBV activity, including 47% receiving TDF. Genotypic lamivudine-resistance detected in 26% of the patients was linked to duration of lamivudine exposure, age, CD4 count and HIV load. Resistance to adefovir (rtA181T/V) was detected in 2.7% of patients. Advanced liver lesions were observed in 54% of cases and were associated with an older age and lower CD4 counts but not with viral load or genotype. Immune escape HBsAg variants were seldom detected. Conclusions Despite the detection of advanced liver lesions in most patients, few were not receiving anti-HBV drugs and for those treated with the most potent anti-HBV drugs, persistent replication suggested non-optimal adherence. Heterogeneity in HBV strains reflects epidemiological differences that may impact liver disease progression. These findings are strong arguments

  15. Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.

    PubMed

    Cauchi, Stéphane; Meyre, David; Dina, Christian; Choquet, Hélène; Samson, Chantal; Gallina, Sophie; Balkau, Beverley; Charpentier, Guillaume; Pattou, François; Stetsyuk, Volodymyr; Scharfmann, Raphaël; Staels, Bart; Frühbeck, Gema; Froguel, Philippe

    2006-10-01

    Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin in the DeCode study. We genotyped the two most associated variants (rs7903146 and rs12255372) in 2,367 French type 2 diabetic subjects and in 2,499 control subjects. Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55-1.83) (P = 6.0 x 10(-35)) and 1.60 (1.47-1.74) (P = 7.6 x 10(-28)), respectively. In nonobese type 2 diabetic subjects (BMI <30 kg/m2, n = 1,346), the ORs increased to 1.89 (1.72-2.09) (P = 2.1 x 10(-38)) and 1.79 (1.62-1.97) (P = 5.7 x 10(-31)), respectively. The rs7903146 T at-risk allele associates with decreased BMI and earlier age at diagnosis in the type 2 diabetic subjects (P = 8.0 x 10(-3) and P = 3.8 x 10(-4), respectively), which is supported by quantitative family-based association tests. TCF7L2 is expressed in most human tissues, including mature pancreatic beta-cells, with the exception of the skeletal muscle. In the subcutaneous and omental fat from obese type 2 diabetic subjects, TCF7L2 expression significantly decreased compared with obese normoglycemic individuals. During rat fetal beta-cell differentiation, TCF7L2 expression pattern mimics the key marker NGN3 (neurogenin 3), suggesting a role in islet development. These data provide evidence that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis.

  16. Learning to perceive English /d/ versus /edh/: A comparison of French, English, and English-French bilingual 4-year-olds

    NASA Astrophysics Data System (ADS)

    Sundara, Megha; Polka, Linda; Campisi, Lisa; Genesee, Fred; Marcoux, Caroline

    2002-05-01

    Recent findings show that discrimination of the English /d-edh/ does not differ for English and French infants (6-8-month-olds and 10-12-month-olds), although English adults clearly outperform French adults on this contrast, which is not phonemic in French. With respect to age effects, English listeners' perception of /d-edh/ improves between infancy and adulthood, whereas French listeners' perception remains unchanged [Polka et al., J. Acoust. Soc. Am. 109, 2190-2200 (2001)]. In the present study, we tested monolingual English, monolingual French, and early English-French bilingual 4-year-olds on the same contrast using the same stimuli and procedures to clarify when facilitative effects of language experience emerge and whether they are affected by bilingualism. Four findings are reported. First, a language effect (English>French) is evident by 4 years of age. Second, among native (English) listeners facilitative effects are evident by 4-years of age (infants<4-year-oldsFrench) listeners discrimination performance is comparable across the age groups tested (infants=4-year-olds=adults). Fourth, bilingual 4-year-olds' performance is virtually identical to that of their French-speaking peers, revealing a strong effect of bilingualism on the perception of this contrast. Several factors contributing to these findings will be discussed.

  17. Strategies for improved French-language health services

    PubMed Central

    Gauthier, Alain P.; Timony, Patrick E.; Serresse, Suzanne; Goodale, Natalie; Prpic, Jason

    2015-01-01

    Abstract Objective To identify strategies to improve the quality of health services for Francophone patients. Design A series of semistructured key informant interviews. Setting Northeastern Ontario. Participants A total of 18 physicians were interviewed. Ten physicians were interviewed in French, 7 physicians were women, and 10 physicians were located in urban communities. Methods Purposive and snowball sampling strategies were used to conduct a series of semistructured key informant interviews with family physicians practising in communities with a large Francophone population. Principles of grounded theory were applied, guided by a framework for patient-professional communication. Results were inductively derived following an iterative data collection–data analysis process and were analyzed using a detailed thematic approach. Main findings Respondents identified several strategies for providing high-quality French-language health services. Some were unique to non–French-speaking physicians (eg, using appropriate interpreter services), some were unique to French-speaking physicians (eg, using a flexible dialect), and some strategies were common to all physicians serving French populations (eg, hiring bilingual staff or having pamphlets and posters in both French and English). Conclusion Physicians interviewed for this study provided high-quality health care by attributing substantial importance to effective communication. While linguistic patient-to-physician concordance is ideal, it might not always be possible. Thus, conscious efforts to attenuate communication barriers are necessary, and several effective strategies exist. PMID:26505060

  18. Comparison of the performance and reliability of 18 lumped hydrological models driven by ECMWF rainfall ensemble forecasts: a case study on 29 French catchments

    NASA Astrophysics Data System (ADS)

    Velázquez, Juan Alberto; Anctil, François; Ramos, Maria-Helena; Perrin, Charles

    2010-05-01

    provide reliable probabilistic forecasts of streamflow, based on ensemble weather predictions. The models were therefore adapted to run in a forecasting mode, i.e., to update initial conditions according to the last observed discharge at the time of the forecast, and to cope with ensemble weather scenarios. All models are lumped, i.e., the hydrological behavior is integrated over the spatial scale of the catchment, and run at daily time steps. The complexity of tested models varies between 3 and 13 parameters. The models are tested on 29 French catchments. Daily streamflow time series extend over 17 months, from March 2005 to July 2006. Catchment areas range between 1470 km2 and 9390 km2, and represent a variety of hydrological and meteorological conditions. The 12 UTC 10-day ECMWF rainfall ensemble (51 members) was used, which led to daily streamflow forecasts for a 9-day lead time. In order to assess the performance and reliability of the hydrological ensemble predictions, we computed the Continuous Ranked probability Score (CRPS) (Matheson and Winkler, 1976), as well as the reliability diagram (e.g. Wilks, 1995) and the rank histogram (Talagrand et al., 1999). Since the ECMWF deterministic forecasts are also available, the performance of the hydrological forecasting systems was also evaluated by comparing the deterministic score (MAE) with the probabilistic score (CRPS). The results obtained for the 18 hydrological models and the 29 studied catchments are discussed in the perspective of improving the operational use of ensemble forecasting in hydrology. References Bartholmes, J. and Todini, E.: Coupling meteorological and hydrological models for flood forecasting, Hydrol. Earth Syst. Sci., 9, 333-346, 2005. Cloke, H. and Pappenberger, F.: Ensemble Flood Forecasting: A Review. Journal of Hydrology 375 (3-4): 613-626, 2009. Jaun, S., Ahrens, B., Walser, A., Ewen, T., and Schär, C.: A probabilistic view on the August 2005 floods in the upper Rhine catchment, Nat. Hazards

  19. Computer-based neuro-vision system for color classification of french fries

    NASA Astrophysics Data System (ADS)

    Panigrahi, Suranjan; Wiesenborn, Dennis

    1995-01-01

    French fries are one of the frozen foods with rising demands in domestic and international markets. Color is one of the critical attributes for quality evaluation of french fries. This study discusses the development of a color computer vision system and the integration of neural network technology for objective color evaluation and classification of french fries. The classification accuracy of a prototype back-propagation network developed for this purpose was found to be 96%.

  20. Association between Prenatal Exposure to Antiretroviral Therapy and Birth Defects: An Analysis of the French Perinatal Cohort Study (ANRS CO1/CO11)

    PubMed Central

    Sibiude, Jeanne; Mandelbrot, Laurent; Blanche, Stéphane; Le Chenadec, Jérôme; Boullag-Bonnet, Naima; Faye, Albert; Dollfus, Catherine; Tubiana, Roland; Bonnet, Damien; Lelong, Nathalie; Khoshnood, Babak; Warszawski, Josiane

    2014-01-01

    Background Antiretroviral therapy (ART) has major benefits during pregnancy, both for maternal health and to prevent mother-to-child transmission of HIV. Safety issues, including teratogenic risk, need to be evaluated. We estimated the prevalence of birth defects in children born to HIV-infected women receiving ART during pregnancy, and assessed the independent association of birth defects with each antiretroviral (ARV) drug used. Methods and Findings The French Perinatal Cohort prospectively enrolls HIV-infected women delivering in 90 centers throughout France. Children are followed by pediatricians until 2 y of age according to national guidelines. We included 13,124 live births between 1994 and 2010, among which, 42% (n = 5,388) were exposed to ART in the first trimester of pregnancy. Birth defects were studied using both European Surveillance of Congenital Anomalies (EUROCAT) and Metropolitan Atlanta Congenital Defects Program (MACDP) classifications; associations with ART were evaluated using univariate and multivariate logistic regressions. Correction for multiple comparisons was not performed because the analyses were based on hypotheses emanating from previous findings in the literature and the robustness of the findings of the current study. The prevalence of birth defects was 4.4% (95% CI 4.0%–4.7%), according to the EUROCAT classification. In multivariate analysis adjusting for other ARV drugs, maternal age, geographical origin, intravenous drug use, and type of maternity center, a significant association was found between exposure to zidovudine in the first trimester and congenital heart defects: 2.3% (74/3,267), adjusted odds ratio (AOR) = 2.2 (95% CI 1.3–3.7), p = 0.003, absolute risk difference attributed to zidovudine +1.2% (95% CI +0.5; +1.9%). Didanosine and indinavir were associated with head and neck defects, respectively: 0.5%, AOR = 3.4 (95% CI 1.1–10.4), p = 0.04; 0.9%, AOR = 3.8 (95% CI 1.1–13.8), p = 0

  1. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF).

    PubMed

    Schnell, David; Azoulay, Elie; Benoit, Dominique; Clouzeau, Benjamin; Demaret, Pierre; Ducassou, Stéphane; Frange, Pierre; Lafaurie, Matthieu; Legrand, Matthieu; Meert, Anne-Pascale; Mokart, Djamel; Naudin, Jérôme; Pene, Frédéric; Rabbat, Antoine; Raffoux, Emmanuel; Ribaud, Patricia; Richard, Jean-Christophe; Vincent, François; Zahar, Jean-Ralph; Darmon, Michael

    2016-12-01

    Neutropenia is defined by either an absolute or functional defect (acute myeloid leukemia or myelodysplastic syndrome) of polymorphonuclear neutrophils and is associated with high risk of specific complications that may require intensive care unit (ICU) admission. Specificities in the management of critically ill neutropenic patients prompted the establishment of guidelines dedicated to intensivists. These recommendations were drawn up by a panel of experts brought together by the French Intensive Care Society in collaboration with the French Group for Pediatric Intensive Care Emergencies, the French Society of Anesthesia and Intensive Care, the French Society of Hematology, the French Society for Hospital Hygiene, and the French Infectious Diseases Society. Literature review and formulation of recommendations were performed using the Grading of Recommendations Assessment, Development and Evaluation system. Each recommendation was then evaluated and rated by each expert using a methodology derived from the RAND/UCLA Appropriateness Method. Six fields are covered by the provided recommendations: (1) ICU admission and prognosis, (2) protective isolation and prophylaxis, (3) management of acute respiratory failure, (4) organ failure and organ support, (5) antibiotic management and source control, and (6) hematological management. Most of the provided recommendations are obtained from low levels of evidence, however, suggesting a need for additional studies. Seven recommendations were, however, associated with high level of evidences and are related to protective isolation, diagnostic workup of acute respiratory failure, medical management, and timing surgery in patients with typhlitis.

  2. French pharmacovigilance: Missions, organization and perspectives.

    PubMed

    Vial, Thierry

    2016-04-01

    Pharmacovigilance aims to identify unknown adverse drug reactions once clinical development is complete, in order to promote improved use of drugs, and thus a reduction in risk for every exposed patient. We describe in this article the missions of French pharmacovigilance system, including French drug agency, Regional Centers of Pharmacovigilance, health professionals, pharmaceutical companies, patients and their associations. We also develop the French pharmacovigilance organization, its perspectives and challenges, both in French and European levels.

  3. Comparison of British and French expatriate doctors’ characteristics and motivations

    PubMed Central

    Quantin, Catherine; Abbas, Rachid; Hagi, Mathieu; Breton, Gwenaelle Le; Romestaing, M; Carnet, Dider

    2012-01-01

    Objective The aim of this study was to analyse the migration of doctors between the UK and France, in an attempt to identify the reasons for these migrations. Design This was a cross-sectional study conducted using a self-completed questionnaire. Setting The questionnaire was sent to all British doctors practising in France and to all French doctors practising in the UK. Participants The doctors were identified, thanks to official data of the National Medical Councils. There were 244 French doctors practising in the UK and 86 British doctors practising in France. Outcome measures A questionnaire was specifically developed for the study to determine the reasons why doctors moved to the other country and their level of satisfaction with regard to their expatriation. Results A total of 98 French doctors (of 244) and 40 British doctors (of 86) returned the questionnaire. The motivations of the two studied populations were different: French doctors were attracted by the conditions offered by the National Health Service, whereas British doctors were more interested in opportunities for career advancement, moved to join a husband or wife or to benefit from favourable environmental conditions. Overall, the doctors who responded considered the expatriation a satisfactory experience. After expatriation, 84% of French doctors were satisfied with their new professional situation compared with only 58% of British doctors. Conclusions This study, which is the first of its kind and based on representative samples, has led to a clearer understanding of the migration of doctors between France and the UK. PMID:23192244

  4. The French Revolution: A Simulation Game

    ERIC Educational Resources Information Center

    Kiernan, James Patrick

    1978-01-01

    Describes a college-level simulation game about the French Revolution. Based on George Lefebvre's "The Coming of the French Revolution," the role-play focuses on social and economic causes of the revolution and allows students to understand citizens' grievances against the French government. (AV)

  5. France: Africans and the French Revolution.

    ERIC Educational Resources Information Center

    Fatunde, Tunde

    1989-01-01

    The French Revolution had profound and long-term effects for Africans, both in Africa and throughout the Western hemisphere. Revolutionary leaders not only opposed the emancipation of slaves in French territories but supported an intensified slave trade, sparking numerous rebellions. French exploitation of Africans extended well into the twentieth…

  6. English versus French: Language Rivalry in Tunisia.

    ERIC Educational Resources Information Center

    Battenburg, John

    1997-01-01

    Examines the competition between English and French in Tunisian educational institutions and programs. Scrutinizes two periods in postprotectorate Tunisia: the introduction of English and the spread of English. Findings indicate that the decline in French linguistic influence may be accompanied by a future decrease in French political and economic…

  7. A Comparative Evaluation of French Grammar Checkers.

    ERIC Educational Resources Information Center

    Burston, Jack

    1996-01-01

    Four grammar checkers, all of French Canadian origin, were evaluated: "Le Correcteur 101,""GramR,""Hugo Plus," and "French Proofing Tools." Results indicate that "Le Correcteur 101" is the best French grammar checker on the market and worth its premium cost. (two references) (CK)

  8. [Human immunodeficiency virus (HIV) infection in mothers and infants in French Guyana. Epidemiologic study apropos of 44 women having conceived 55 children].

    PubMed

    Pradinaud, R; Sainte-Marie, D; Plat, J M; Cassiede, P; Vienne, P; Vigneron-Meleder, H; Wojcick, L; Wojcick, J M; Sankale-Suzanon, J; Patient, G

    1989-01-01

    The French Guyana is an Overseas French Department in South America, with 100,000 inhabitants among them are 20% of Haitian immigrants. At 31 December 1987, 103 AIDS cases have been recorded, 86% by heterosexual transmission. The first case dated May 1979 was retroactively diagnosed in an Haitian parturient, thank to her serum kept in the Pasteur institute of Cayenne. 44 women got their pregnancy during their HIV infection: 5 with clinical and biological evidence of AIDS, 7 developed AIDS after getting pregnant, and 10 out of these 12 women died. All of them were from a rather low social group and, generally, were not married. 43 are black (40 Haitians and 3 Guyanese Creoles), one is Indian and presented some psychic disorders. The mean age was 32 1/2 (from 15 to 51 years old). 55 babies were born: 12 developed AIDS (6 died during the first 15 months of their life); 14 are HIV +, 3 stillborns, 4 never tested and 22 developed negative reaction (with ELISA and Western-Blot) between 7.5 and 10 months of their life. Two Hutchinson's triads were observed. Prurigo is the most commonly skin manifestation observed.

  9. An Interview with Fiona French

    ERIC Educational Resources Information Center

    Lewis, David

    2005-01-01

    In this interview Fiona French discusses her work and career with David Lewis. She describes early influences and stresses her lifelong love of colour and pattern. Amongst other themes she considers the factual basis of most of her books and her lack of interest in fantasy; her preference for clear, simple prose; her constant shifts in style and…

  10. Normenbuch Franzoesisch (Norm Book French)

    ERIC Educational Resources Information Center

    Pamp, Friedhelm

    1976-01-01

    Critizes the Norm Book for French Final (Abitur) Examination 1975 for German Schools, as to its arrangement and some resulting difficulties; also for its over-emphasis on written work over speaking. Additional publications are needed to make the existing requirements more specific. (Text is in German.) (IFS/WGA)

  11. Guide to French Noun Gender.

    ERIC Educational Resources Information Center

    Wilson, Perkins

    This guide presents a system for determining the qender of French nouns that has been tested against 12,000 pages of general reading: novels, history, social science, law, finance, and the Bible. The guide discusses the rules for determining gender and also presents various lists of the non-routine or exceptions to the rules. It is asserted that…

  12. [Herman Lundborg and French eugenicists].

    PubMed

    Drouard, A

    1999-01-01

    Herman Lundborg, the director of the Institute of Racial Biology in Uppsala, corresponded with some prominent French eugenicists in the 1920s and 1930s. The historical context of this correspondence is analyzed, and the importance of the national differences as well as of the international eugenic organization's efforts are emphasized.

  13. French on the Advanced Level.

    ERIC Educational Resources Information Center

    Pawlik, Teresa Wilkinson

    1969-01-01

    Presented in this article is an outline of some of the special interest course work included in the curriculum guidelines being developed in the Atlanta Public Schools System for advanced secondary school French classes. Titles of the audiolingually-oriented courses described are--(1) "Teenagers and Teenage Life in France Today," (2)…

  14. Cinque's Functional Verbs in French

    ERIC Educational Resources Information Center

    Rowlett, Paul

    2007-01-01

    This article focuses on the syntax of a number of subcategories of verb in French which are compatible with a following bare infinitive and which express various kinds of grammatical tense, mood, modality, aspect and voice, as well as such (more lexical?) notions as perception, causation and locomotion. The article starts by cataloguing a number…

  15. Some "English" Words in French.

    ERIC Educational Resources Information Center

    Thogmartin, Clyde

    1984-01-01

    Examines "pseudoborrowing" of some English words into the French vocabulary. Considered the prestige language of Western Europe, English is viewed as a social hallmark of higher education; thus, even a modest knowledge and use of English reinforces this attitude. However, also suggests a modification of this concept, noting a reciprocal prestige…

  16. Verlan: Talking Backwards in French.

    ERIC Educational Resources Information Center

    Lefkowitz, Natalie J.

    1989-01-01

    The history of "Verlan," a form of French word play involving inversion of syllables with varying degrees of complexity, is described and its phonological and morphological patterns are outlined. Appropriate and inappropriate contexts for use of Verlan, extralinguistic functions, and the results of lexicalization of verlanized words are…

  17. [Composite editorial contents in French chemical journals].

    PubMed

    Dalbin, Sylvie

    2014-01-01

    This study of a corpus of French chemistry journals between 1800 and 2010 shows the relevance of the journal as the primary mode of communication, confirming the results of the general survey presented in this issue. However, a study of their contents is questioning the apparent unity of this phenomenon: the journal appears as a physical medium consisting in a common container including a wide range of information categories transferred over time to digital platforms in development since the end of the 20(th) century.

  18. Enhanced anatexis as a consequence of mantle-derived magma intrusion in the middle crust: a case study from the Eastern French Massif Central

    NASA Astrophysics Data System (ADS)

    Couzinié, Simon; Moyen, Jean-François; Villaros, Arnaud; Paquette, Jean-Louis; Scarrow, Jane H.; Marignac, Christian

    2014-05-01

    The post-collisional stage of orogens corresponds to a dramatic change in mountain belts dynamics. During this period, large volumes of granitic melts are generated in the crust thus impacting its rheology and overall behavior. Evolving from compression/transpression to extension/transtension enhances exhumation of high-grade metamorphic rocks and subsequent decompression crustal melting. However, other processes can trigger anatexis such as heat or fluid fluxes from the mantle and the crust. The Early Carboniferous nappe stack of the Eastern French Massif Central (EFMC) underwent two successive low-pressure melting events at the end of its evolution, during the Late Carboniferous. They are particularily evident in the southern edge of the Velay Complex, a 100 km-diameter migmatite-granite dome. The M3 'pre-Velay' event corresponds to water-saturated melting in the amphibolite facies at T < 750 ° C, P ≥ 5 kbar. It is recorded by cordierite-free, stromatic migmatites and was quite long-lasting since available U-Th-Pb monazite ages span from 335 to 310 Ma. At that time, crustal melts mainly remained trapped in the source and few granite plutons were associated with this event. Contrarily, the M4 'Velay' anatexis occurred under granulite-facies conditions at 760 < T < 850 ° C and 2 < P < 5 kbar. The M4 cordierite-bearing migmatites are nebulitic to diatexitic as a consequence of biotite breakdown which led to disruption of the solid framework of melanosomes and enhanced melt extraction. This widespread melting event is synchronous with emplacement of the cordierite-bearing restite-rich S-type Velay granite at ca. 305 Ma. Then, the EFMC records an evolution in melting conditions with a clear heat input at the M3-M4 transition. The EFMC anatectic crust is intruded by widespread, Mg-K-rich biotite-rich diorites locally called 'vaugnerites'. These mantle-derived melts emplaced in a partially molten setting, as evidenced by mingling features between vaugnerites and

  19. The Mini Mental State Examination at the Time of Alzheimer's Disease and Related Disorders Diagnosis, According to Age, Education, Gender and Place of Residence: A Cross-Sectional Study among the French National Alzheimer Database

    PubMed Central

    Pradier, Christian; Sakarovitch, Charlotte; Le Duff, Franck; Layese, Richard; Metelkina, Asya; Anthony, Sabine; Tifratene, Karim; Robert, Philippe

    2014-01-01

    The aim of this study was firstly to describe the MMSE (Mini-Mental State Examination) score upon initial diagnosis of Alzheimer's disease and related disorders among the French population, according to age. Secondly, education, gender and place of residence were studied as factors potentially associated with delayed Alzheimer's disease diagnosis. Design we conducted a cross sectional analysis of the French National Alzheimer database (BNA). Data from 2008 to 2012 were extracted. Patients were selected at the moment of their first diagnosis of AD (n = 39,451). Results The MMSE score at initial diagnosis dropped significantly with increasing age. The test score increased with the degree of educational background regardless of age. Gender and place of residence were significantly related to the MMSE score, women and persons living in medical institutions having lower MMSE scores under the age of 90 years and at all educational levels. Conclusions Health care professionals should be aware of these risk factors in order to maximize chances of earliest possible diagnosis of Alzheimer's disease and related disorders. PMID:25093735

  20. Corporate Image and the Establishment of Euro Disney: Mickey Mouse and the French Press.

    ERIC Educational Resources Information Center

    Forman, Janis

    1998-01-01

    Considers interweaving themes that characterized the construction of Euro Disney, drawing upon articles in the French press. Offers analysis of the historical context for and the implications of the park's construction, using the literature of French cultural studies and cross-cultural studies for support. Discusses possible consequences to the…

  1. Teaching Methodology in a First-Grade French-Immersion Class

    ERIC Educational Resources Information Center

    Akcan, Sumru

    2004-01-01

    This micro-ethnographic classroom-based case study explores the teaching methodology in a first-grade French-immersion class. This study was carried out in a public elementary immersion school in Milwaukee, Wisconsin, where English-speaking children throughout the school learn the school curriculum through a second language (French), starting in…

  2. On-Line Grammaticality Judgments in French Children and Adults: A Crosslinguistic Perspective

    ERIC Educational Resources Information Center

    Kail, Michele

    2004-01-01

    This study examined the on-line processing of French sentences in a grammaticality judgment experiment. Three age groups of French children (mean age: 6;8, 8;6 and 10;10 years) and a group of adults were asked to detect grammatical violations as quickly as possible. Three factors were studied: the violation type: agreement violations (number and…

  3. The spelling skills of French-speaking dyslexic children.

    PubMed

    Plisson, Anne; Daigle, Daniel; Montésinos-Gelet, Isabelle

    2013-05-01

    Learning to spell is very difficult for dyslexic children, a phenomenon explained by a deficit in processing phonological information. However, to spell correctly in an alphabetic language such as French, phonological knowledge is not enough. Indeed, the French written system requires the speller to acquire visuo-orthographical and morphological knowledge as well. To date, the majority of studies aimed at describing dyslexic children's spelling abilities related to English and reading. The general goal of this study is to describe the spelling performance, from an explanatory perspective, of 26 French-Canadian dyslexic children, aged 9 to 12 years. The specific goals are to describe the spelling performances of these pupils in the context of free production and to compare them with the performances of 26 normally achieving children matched on age (CA) and with those of 29 younger normally achieving children matched on reading age (RA). To do so, errors were classified according to phonological, visuo-orthographical and morphological properties of French written words. The results indicate that the dyslexic group scored lower than the CA group but sometimes also lower than the RA group. The results are discussed according to the types of knowledge required to spell correctly in French.

  4. [SURPS French version validation in a Quebec adolescent population].

    PubMed

    Castonguay-Jolin, Laura; Perrier-Ménard, Eveline; Castellanos-Ryan, Natalie; Parent, Sophie; Vitaro, Frank; Tremblay, Richard E; Garel, Patricia; Séguin, Jean R; Conrod, Patricia J

    2013-09-01

    Objective: The Substance Use Risk Profile Scale (SURPS) has been developed to screen personality risk factors for substance misuse. This scale assesses 4 high-risk personality traits using a 23-item, self-report questionnaire. SURPS helps guiding targeted approaches to prevention of substance abuse and misuse. It has been validated in the United Kingdom, English Canada, Sri Lanka, and China. This study aims to validate this scale in a sample of French-speaking adolescents from Quebec as well as its sensitivity in a clinical sample of adolescents. Method: Two hundred two 15-year-old youths from a community sample completed a French version of SURPS as well as other measures of personality and substance use. This study reports the internal consistency and concurrent validity of the scale, as well as a factor analysis of items. Further, 40 youths (mean age 15.7 years) from a clinical population completed SURPS and their scores were compared with those of the community sample. Results: SURPS French translation has good internal consistency and demonstrated a 4-factor structure very similar to the original scale. The 4 subscales show good concurrent validity, and 3 of the subscales were found to correlate with measures of substance use. Finally, 95% of the clinical sample was identified at high risk for substance misuse according to SURPS cut-off scores. Conclusion: SURPS French translation seems to be a valid and sensitive scale that can be used in a French-speaking adolescent population from Quebec.

  5. Physical fitness reference standards in French youth: The BOUGE program.

    PubMed

    Vanhelst, Jérémy; Julien, Julien Labreuche; Beghin, Laurent; Drumez, Elodie; Fardy, Paul S; Chapelot, Didier; Mikulovic, Jacques; Ulmer, Zekya

    2016-09-16

    The aim of this study was to establish gender- and age-specific physical fitness percentiles in French youth. A sample of 11 186 children and adolescents (5 546 boys, 5 640 girls), ages 10-15 years, was assessed in the French national BOUGE study. Participants were tested on cardiorespiratory fitness, muscular endurance, speed, flexibility and agility using the following tests: 20-m shuttle run tests, curl ups test, 50-m sprint test, back-saver sit and reach test and 10 x 5 m shuttle run test. Percentile values were estimated for French youth as a function of age stratified by gender using the generalized additive model for location, scale and shape (GAMLSS). In general, physical fitness was better in boys than girls, except for the back-saver sit and reach test, in which girls performed better. Except for the back-saver sit and reach test and 10 x 5 m shuttle run test, physical fitness performance was significantly associated with age. Gender and age-specific normative values for physical fitness tests in French youth expressed as percentiles from the 5th to the 95th are provided. Reference values provide normative data for French youth. The data are useful in identifying special needs for appropriate intervention programs.

  6. Cigeo, the French Geological Repository Project - 13022

    SciTech Connect

    Labalette, Thibaud; Harman, Alain; Dupuis, Marie-Claude; Ouzounian, Gerald

    2013-07-01

    The Cigeo industrial-scale geological disposal centre is designed for the disposal of the most highly-radioactive French waste. It will be built in an argillite formation of the Callovo-Oxfordian dating back 160 million years. The Cigeo project is located near the Bure village in the Paris Basin. The argillite formation was studied since 1974, and from the Meuse/Haute-Marne underground research laboratory since end of 1999. Most of the waste to be disposed of in the Cigeo repository comes from nuclear power plants and from reprocessing of their spent fuel. (authors)

  7. Norovirus contamination on French marketed oysters.

    PubMed

    Schaeffer, Julien; Le Saux, Jean-Claude; Lora, Monica; Atmar, Robert L; Le Guyader, Françoise S

    2013-09-02

    Contaminated shellfish have been implicated in gastroenteritis outbreaks in different countries. As no regulation has been set up yet regarding viral contamination of food, very few data are available on the prevalence of contaminated products on the market. This study presents data obtained from oysters collected on the French market in one producing area over a 16 month period of time. Noroviruses were detected in 9% of samples with a seasonal impact and influence of climatic events. Contamination levels were low and, surprisingly, oysters sampled directly from the producer were found to have less contamination than oysters from supermarkets.

  8. Norovirus contamination on French marketed oysters

    PubMed Central

    Schaeffer, Julien; Le Saux, Jean-Claude; Lora, Monica; Atmar, Robert L.; Le Guyader, Françoise S.

    2014-01-01

    Contaminated shellfish have been implicated in gastroenteritis outbreaks in different countries. As no regulation has been set up yet regarding viral contamination of food, very few data are available on the prevalence of contaminated products on the market. This study presents data obtained from oysters collected on the French market in one producing area over a 16 month period of time. Noroviruses were detected in 9% of samples with a seasonal impact and influence of climatic events. Contamination levels were low and, surprisingly, oysters sampled directly from the producer were found to have less contamination than oysters from supermarkets. PMID:23973835

  9. Does use of tropical beaches by tourists and island residents result in damage to fringing coral reefs? A case study in Moorea French Polynesia.

    PubMed

    Juhasz, Allison; Ho, Ellen; Bender, Erika; Fong, Peggy

    2010-12-01

    Although coral reefs worldwide are subject to increasing global threats, humans also impact coral reefs directly through localized activities such as snorkeling, kayaking and fishing. We investigated five sites on the northern shore of Moorea, French Polynesia, and quantified the number of visitors on the beach and in shallow water. In field surveys, we measured total coral cover and colony sizes of two common genera, Porites and Acropora, a massive and branching morphology, respectively. One site, which hosted over an order of magnitude more people than the other four, had significantly less total coral cover and supported very little branching Acropora. In addition, size frequency distributions of both the branching and massive genera were skewed toward smaller colony sizes at the high use site. Our results demonstrated that the use of tropical beaches may result in less coral cover, with branching colonies rare and small.

  10. Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group.

    PubMed

    Soufir, N; Avril, M F; Chompret, A; Demenais, F; Bombled, J; Spatz, A; Stoppa-Lyonnet, D; Bénard, J; Bressac-de Paillerets, B

    1998-02-01

    Germline mutations in the p16 and CDK4 genes have been reported in a subset of melanoma pedigrees, but their prevalence is not well known. We searched for such germline mutations in 48 French melanoma-prone families selected according to two major criteria: families with at least three affected members (n = 20) or families with two affected members, one of them affected before the age of 50 (n = 28), and one additional minor criterion. Sixteen different p16 germline mutations were found in 21 families, while one germline mutation, Arg24His, was detected in the CDK4 gene. The frequency of p16 gene mutation in our sample (44%) is among the highest rates yet reported and the CDK4 mutation is the second mutation detected in this gene worldwide. In summary, our results show frequent involvement of the p16 gene in familial melanoma and confirm the role of the CDK4 gene as a melanoma-predisposing gene.

  11. Does language matter? A case study of epidemiological and public health journals, databases and professional education in French, German and Italian

    PubMed Central

    Baussano, Iacopo; Brzoska, Patrick; Fedeli, Ugo; Larouche, Claudia; Razum, Oliver; Fung, Isaac C-H

    2008-01-01

    Epidemiology and public health are usually context-specific. Journals published in different languages and countries play a role both as sources of data and as channels through which evidence is incorporated into local public health practice. Databases in these languages facilitate access to relevant journals, and professional education in these languages facilitates the growth of native expertise in epidemiology and public health. However, as English has become the lingua franca of scientific communication in the era of globalisation, many journals published in non-English languages face the difficult dilemma of either switching to English and competing internationally, or sticking to the native tongue and having a restricted circulation among a local readership. This paper discusses the historical development of epidemiology and the current scene of epidemiological and public health journals, databases and professional education in three Western European languages: French, German and Italian, and examines the dynamics and struggles they have today. PMID:18826570

  12. French roots of French neo-lamarckisms, 1879-1985.

    PubMed

    Loison, Laurent

    2011-01-01

    This essay attempts to describe the neo-Lamarckian atmosphere that was dominant in French biology for more than a century. Firstly, we demonstrate that there were not one but at least two French neo-Lamarckian traditions. This implies, therefore, that it is possible to propose a clear definition of a (neo)Lamarckian conception, and by using it, to distinguish these two traditions. We will see that these two conceptions were not dominant at the same time. The first French neo-Lamarckism (1879-1931) was structured by a very mechanic view of natural processes. The main representatives of this first period were scientists such as Alfred Giard (1846-1908), Gaston Bonnier (1853-1922) and Félix Le Dantec (1869-1917). The second Lamarckism - much more vitalist in its inspiration - started to develop under the supervision of people such as Albert Vandel (1894-1980) and Pierre-Paul Grassé (1895-1985). Secondly, this essay suggests that the philosophical inclinations of these neo-Lamarckisms reactivated a very ancient and strong dichotomy of French thought. One part of this dichotomy is a material, physicalist tradition, which started with René Descartes but developed extensively during the 18th and 19th centuries. The other is a spiritual and vitalist reaction to the first one, which also had a very long history, though it is most closely associated with the work of Henri Bergson. Through Claude Bernard, the first neo-Lamarckians tried to construct a mechanical and determinist form of evolutionary theory which was, in effect, a Cartesian theory. The second wave of neo-Lamarckians wanted to reconsider the autonomy and reactivity of life forms, in contrast to purely physical systems.

  13. Are different facets of plant diversity well protected against climate and land cover changes? A test study in the French Alps

    PubMed Central

    Thuiller, Wilfried; Guéguen, Maya; Georges, Damien; Bonet, Richard; Chalmandrier, Loïc; Garraud, Luc; Renaud, Julien; Roquet, Cristina; Van Es, Jérémie; Zimmermann, Niklaus E.; Lavergne, Sébastien

    2014-01-01

    Climate and land cover changes are important drivers of the plant species distributions and diversity patterns in mountainous regions. Although the need for a multifaceted view of diversity based on taxonomic, functional and phylogenetic dimensions is now commonly recognized, there are no complete risk assessments concerning their expected changes. In this paper, we used a range of species distribution models in an ensemble-forecasting framework together with regional climate and land cover projections by 2080 to analyze the potential threat for more than 2,500 plant species at high resolution (2.5 km × 2.5 km) in the French Alps. We also decomposed taxonomic, functional and phylogenetic diversity facets into α and β components and analyzed their expected changes by 2080. Overall, plant species threats from climate and land cover changes in the French Alps were expected to vary depending on the species’ preferred altitudinal vegetation zone, rarity, and conservation status. Indeed, rare species and species of conservation concern were the ones projected to experience less severe change, and also the ones being the most efficiently preserved by the current network of protected areas. Conversely, the three facets of plant diversity were also projected to experience drastic spatial re-shuffling by 2080. In general, the mean α-diversity of the three facets was projected to increase to the detriment of regional β-diversity, although the latter was projected to remain high at the montane-alpine transition zones. Our results show that, due to a high-altitude distribution, the current protection network is efficient for rare species, and species predicted to migrate upward. Although our modeling framework may not capture all possible mechanisms of species range shifts, our work illustrates that a comprehensive risk assessment on an entire floristic region combined with functional and phylogenetic information can help delimitate future scenarios of biodiversity and

  14. The French Space Operations Act: Technical Regulations

    NASA Astrophysics Data System (ADS)

    Lazare, B.

    2013-12-01

    The French Space Operations Act (FSOA) [1] stipulates that one of the National Technical Regulations' prime objectives is to protect people, property, public health and the environment. Compliance with these Technical Regulations has been mandatory since 10 December, 2010 for space operations by French space operators and for space operations conducted on French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by applicant space operators, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting the Technical Regulations are as follows: requirements must, as far as possible, establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being state of the art; requirements must take previous experience into account. The Technical Regulations are divided into three sections covering requirements common to the launch, control and return of a space object. A special section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the Technical Regulations are: operator safety management system; study of risks to people, property, public health and the Earth's environment; impact study on the outer space environment: space debris generated by the operation; planetary protection. The first version of the Technical Regulations [2], issued in March 2011, is dedicated to unmanned space systems.

  15. French Sizing of Medical Devices is not Fit for Purpose

    SciTech Connect

    Kibriya, Nabil Hall, Rebecca; Powell, Steven; How, Thien; McWilliams, Richard G.

    2013-08-01

    PurposeThe purpose of the study is to quantify the variation in the metric equivalent of French size in a range of medical devices, from various manufacturers, used in interventional radiology.MethodsThe labelling of a range of catheters, introducers, drains, balloons, stents, and endografts was examined. Products were chosen to achieve a broad range of French sizes from several manufacturers. To assess manufacturing accuracy, eight devices were selected for measurement using a laser micrometer. The external diameters of three specimens of each device were measured at centimeter intervals along the length of the device to ensure uniformity.ResultsA total of 200 labels of interventional radiology equipment were scrutinized. The results demonstrate a wide variation in the metric equivalent of French sizing. Labelled products can vary in diameter across the product range by up to 0.79 mm.The devices selected for measurement with the non-contact laser micrometer demonstrate acceptable manufacturing consistency. The external diameter differed by 0.05 mm on average.ConclusionsOur results demonstrate wide variation in the interpretation of the French scale by different manufacturers of medical devices. This has the potential to lead to problems using coaxial systems especially when the products are from different manufacturers. It is recommended that standard labelling should be employed by all manufacturers conveying specific details of the equipment. Given the wide variation in the interpretation of the French scale, our opinion is that this scale either needs to be abandoned or be strictly defined and followed.

  16. Snow management practices in French ski resorts

    NASA Astrophysics Data System (ADS)

    Spandre, Pierre; Francois, Hugues; George-Marcelpoil, Emmanuelle; Morin, Samuel

    2016-04-01

    Winter tourism plays a fundamental role in the economy of French mountain regions but also in other countries such as Austria, USA or Canada. Ski operators originally developed grooming methods to provide comfortable and safe skiing conditions. The interannual variability of snow conditions and the competition with international destinations and alternative tourism activities encouraged ski resorts to mitigate their dependency to weather conditions through snowmaking facilities. However some regions may not be able to produce machine made snow due to inadequate conditions and low altitude resorts are still negatively impacted by low snow seasons. In the meantime, even though the operations of high altitude resorts do not show any dependency to the snow conditions they invest in snowmaking facilities. Such developments of snowmaking facilities may be related to a confused and contradictory perception of climate change resulting in individualistic evolutions of snowmaking facilities, also depending on ski resorts main features such as their altitude and size. Concurrently with the expansion of snowmaking facilities, a large range of indicators have been used to discuss the vulnerability of ski resorts such as the so-called "100 days rule" which was widely used with specific thresholds (i.e. minimum snow depth, dates) and constraints (i.e. snowmaking capacity). The present study aims to provide a detailed description of snow management practices and major priorities in French ski resorts with respect to their characteristics. We set up a survey in autumn 2014, collecting data from 56 French ski operators. We identify the priorities of ski operators and describe their snowmaking and grooming practices and facilities. The operators also provided their perception of the ski resort vulnerability to snow and economic challenges which we could compare with the actual snow conditions and ski lift tickets sales during the period from 2001 to 2012.

  17. Student and Teacher Perceptions of First Language Use in Secondary French Immersion Mathematics Classrooms

    ERIC Educational Resources Information Center

    Culligan, Karla

    2015-01-01

    This phenomenological study (Creswell, 2003, 2007; van Manen, 1997) explores student and teacher perceptions of first language use in French immersion mathematics classrooms at a large, urban high school in Canada. During individual interviews, participants discussed their perceptions and experiences of French immersion mathematics, language use,…

  18. Neuropsychological Profile on the WISC-IV of French Children with Dyslexia

    ERIC Educational Resources Information Center

    De Clercq-Quaegebeur, Maryse; Casalis, Severine; Lemaitre, Marie-Pierre; Bourgois, Beatrice; Getto, Marie; Vallee, Louis

    2010-01-01

    This study examined the pattern of results on the "Wechsler Intelligence Scale for Children" (WISC-IV; French version) for 60 French children with dyslexia, from 8 to 16 years of age. Although use of WISC-III failed to clearly identify typical profiles and cognitive deficits in dyslexia, WISC-IV offers an opportunity to reach these…

  19. Phonetic Influences on English and French Listeners' Assimilation of Mandarin Tones to Native Prosodic Categories

    ERIC Educational Resources Information Center

    So, Connie K.; Best, Catherine T.

    2014-01-01

    This study examined how native speakers of Australian English and French, nontone languages with different lexical stress properties, perceived Mandarin tones in a sentence environment according to their native sentence intonation categories (i-Categories) in connected speech. Results showed that both English and French speakers categorized…

  20. French Interrogative Structures: A New Pedagogical Norm for the 21st-Century Classroom

    ERIC Educational Resources Information Center

    Antes, Theresa A.

    2016-01-01

    This study investigated interrogative structures most frequently used by native speakers of French, in an attempt to reconcile differences between language forms taught in the French as a foreign language classroom and those that are encountered in authentic input. Radio, television, and magazine interviews provided multiple examples of…

  1. Matching Intended and Actual French Curriculum Objectives in Secondary Schools in Western Province, Kenya

    ERIC Educational Resources Information Center

    Omusonga, T. O.; Kazadi, I. M.; Indoshi, F. C.

    2009-01-01

    Intended French curriculum objectives refer to four official objectives of teaching and learning French in secondary schools in Kenya as laid down in syllabuses; namely, to equip learners with basic communicative skills, give learners access to oral and written materials, facilitate further studies, and promote global peace (Republic of Kenya,…

  2. Validating the Measurement and Structure of the Beck Depression Inventory across English and French Nonclinical Adolescents.

    ERIC Educational Resources Information Center

    Byrne, Barbara M.; Baron, Pierre

    The aims of the present study were threefold: (1) to test for the equivalency of an hierarchical three-factor structure of the Beck Depression Inventory (BDI) across English and French versions for non-clinical adolescents; (2) given evidence of poor model fit, to validate the factorial structure of the BDI French version across three independent…

  3. Natural Gender, Phonological Cues and the Default Grammatical Gender in French Children

    ERIC Educational Resources Information Center

    Boloh, Yves; Ibernon, Laure

    2013-01-01

    According to a dominant thesis, nominal endings are the privileged cues French children use to determine new nouns' gender subclass. Children will rely on phonology even in cases of discordance with natural gender. Two elicited production studies involving more than 250 4- to 17-year-olds showed that while French children did not base their gender…

  4. Cognate Awareness in French Immersion Students: Contributions to Grade 2 Reading Comprehension

    ERIC Educational Resources Information Center

    Hipfner-Boucher, Kathleen; Pasquarella, Adrian; Chen, Xi; Deacon, S. Hélène

    2016-01-01

    Cognate awareness is the ability to recognize the cognate relationship between words in two etymologically related languages. The current study examined the development of cognate awareness and its contribution to French (second language) reading comprehension among Canadian French immersion children. Eighty-one students were tested at the end of…

  5. Intergenerational Pattern of Interference and Internally-Motivated Changes in Cajun French

    ERIC Educational Resources Information Center

    Dubois, Sylvie; Noetzel, Sibylle

    2005-01-01

    We examine the variable use of locative prepositions in Cajun French, adding two dimensions to existing studies: real-time evidence, adding a diachronic descriptive perspective, and a methodological tool, measuring the degree of exposure to French (MDI). The goal of this paper is to determine the origins and the directions of language change…

  6. Lexical Richness in the Advanced Learner's Oral Production of French and Italian L2

    ERIC Educational Resources Information Center

    Lindqvist, Christina; Bardel, Camilla; Gudmundson, Anna

    2011-01-01

    This study investigates Swedish learners' lexical richness in French and Italian L2. A frequency-based measure was used to compare the lexical richness of learners at different proficiency levels to that of native speakers. Frequency bands based on oral L1 data were created for both languages to serve as a benchmark. For French, the results show…

  7. The Status of the "Weaker" Language in Unbalanced French/German Bilingual Language Acquisition

    ERIC Educational Resources Information Center

    Bonnesen, Matthias

    2009-01-01

    In this paper, I investigate the status of the so-called "weaker" language, French, in French/German bilingual first language acquisition, using data from two children from the DuFDE-corpus (see Schlyter, 1990a), Christophe and Francois. Schlyter (1993, 1994) proposes that the "weaker" language in the unbalanced children she studied has the status…

  8. Learners' Selective Perceptions of Information during Instructed Learning in French: Consequences

    ERIC Educational Resources Information Center

    Drewelow, Isabelle

    2011-01-01

    The present study examined how American learners of French perceived the influence of instruction on their existing stereotypes about the French people to determine the effects of these stereotypes on their language learning and cultural openness. During a semester, 22 undergraduate students, all native English speakers enrolled in 4 sections of…

  9. Pitch Cues for the Recognition of Yes-No Questions in French

    ERIC Educational Resources Information Center

    Vion, Monique; Colas, Annie

    2006-01-01

    Linguistic studies of the intonation of Yes-No questions in French show that, in questions containing more than two stress groups, interrogative intonation is characterized by a sequence of lowered pitches or downstepped tones which precede the final rise. The gating paradigm was used here to determine whether subjects listening to French NP…

  10. Why Choose French? Boys' and Girls' Attitudes at the Option Stage.

    ERIC Educational Resources Information Center

    Powell, Robert; Littlewood, Peter

    1983-01-01

    A survey of secondary students' attitudes toward French as a second language in two schools analyzed how students' choice or rejection of the subject was related to career choice, sex, social class, travel in France, and success in French. A secondary intent was to refine attitude study techniques. (MSE)

  11. French space activities

    NASA Technical Reports Server (NTRS)

    Blanc, R.

    1982-01-01

    The four main points of research and development of space programs by France are explained. The National Center of Space Studies is discussed, listing the missions of the Center and describing the activities of the staff.

  12. The Teaching of Medieval French at the Undergraduate Level.

    ERIC Educational Resources Information Center

    Cohen, Anne-Lise

    Criticism of the apparent academic disregard of Old French at the undergraduate level includes suggestions on ways to expand the curriculum. Discussion of philology, historical grammar, student preparation, course requirements, and the history of language is developed. Benefits of medieval study relate to: (1) preparation for graduate study, (2)…

  13. Language Learning Experiences of Australian French Immersion Students.

    ERIC Educational Resources Information Center

    de Courcy, Michele

    Drawing on a 1993 study of four students in a late French immersion program in Australia and findings from a 1991 study, the report looks at three areas: students' response to the learning context, including its more and less helpful characteristics; the experiences students consider most important for learning the language, including those…

  14. Technology for French Learning: A Mismatch between Expectations and Reality

    ERIC Educational Resources Information Center

    Karabulut, Aliye; Levelle, Kimberly; Li, Jinrong; Suvorov, Ruslan

    2012-01-01

    The qualitative study reported in this article explored the use of technology for language learning in a third-year French class at a public university in the Midwest of the USA. To address the need for a more holistic study of technology for language learning (Basharina, 2007; Thorne, 2003), an Activity Theory framework was employed to…

  15. Mismatch of Vocational Graduates: What Penalty on French Labour Market?

    ERIC Educational Resources Information Center

    Beduwe, Catherine; Giret, Jean-Francois

    2011-01-01

    This study explores individual effects of educational mismatch on wages, job satisfaction and on-the-job-search on French labour market. We distinguish between horizontal matches (job matches with field of studies) and vertical matches (job matches the level of qualification) on the one hand and skills matches (worker's assessment) on the other…

  16. French security policy: From independence to interdependence

    SciTech Connect

    Laird, R.F.

    1986-01-01

    The book features the first-time translation of some of the most significant recent papers by leading French analysts of security affairs. Beginning with a look at continuity and change in French policy since de Gaulle, this books presents the evolution of French security policy in the 1970s and 1980s. Dr. Laird pays special attention to the French nuclear modernization process and to the trend in the last two decades toward greater emphasis on security interdependence within the Western Alliance at the expense of the classic Gaullist stance of independence. He examines the major dimensions of French security policy, particularly French nuclear employment policy and doctrine, the Franco-German relationship, and France's role in Europe and in East-West relations.

  17. Transmission of HIV by transfusion of HIV-screened blood: the value of a national register. The 'Recipients' Study Group of the French Society of Blood Transfusion.

    PubMed

    Courtois, F; Jullien, A M; Chenais, F; Noel, L; Pinon, F

    1992-03-01

    A National Register of transfusion-transmitted infections was opened by the French Society of Blood Transfusion on 1 October, 1986. Out of 54 initially reported cases of HIV-infection, allegedly transmitted by blood components, further investigation could be completed in 33 cases. The transfusional origin of contamination was considered as established or probable in 28/33 cases, either because a potentially infectious unit was identified among those transfused to the recipient (23/28), or because the recipient was known to be seronegative before transfusion (5/28), or both (10/28). In 5/33 cases transfusion was considered as presumably responsible for contamination because no other risk factor was found in the recipient. Among the 33 documented cases of HIV-transmission by screened blood, 29 (88%) occurred between 1985 and 1987, and four (12%) during 1988. Out of 19 implicated donors later found seropositive, 16 belonged to a high-risk group for HIV-infection. The majority of HIV-infections occurred as a consequence of blood donation in the window period between contamination and the appearance of detectable antibodies in the donor's serum (11/19). In three instances, however, human and operational errors led to the release of seropositive units. We conclude that the main value of this Register is to provide a potential trend-indicator of transfusion-related infectious risks, to allow objective documentation of reported cases and to contribute to the improvement of blood transfusion practice.

  18. Tobacco smoking, alcohol drinking and risk of oral cavity cancer by subsite: results of a French population-based case-control study, the ICARE study.

    PubMed

    Radoï, Loredana; Paget-Bailly, Sophie; Cyr, Diane; Papadopoulos, Alexandra; Guida, Florence; Schmaus, Annie; Cénée, Sylvie; Menvielle, Gwenn; Carton, Matthieu; Lapôtre-Ledoux, Bénédicte; Delafosse, Patricia; Stücker, Isabelle; Luce, Danièle

    2013-05-01

    The objective was to examine the role of tobacco smoking and alcohol drinking in the incidence of oral cavity cancer by subsite in France, a high-incidence area. We analysed detailed data on lifelong tobacco smoking and alcohol drinking from 772 oral cavity cancer cases and 3555 controls included in a population-based case-control study, the ICARE study. Tobacco smoking increased the risk of oral cavity cancer even for the smaller quantities and durations, whereas alcohol drinking increased this risk only in heavy drinkers who were also ever smokers. The combined effect of smoking and drinking was greater than multiplicative. The floor of the mouth was the subsite that was the most affected by the harmful effects of tobacco and alcohol, whereas the gums were less susceptible. The risk associated with tobacco and alcohol consumption did not differ between intraoral cavity and subsites usually included in the oropharynx (soft palate and base of the tongue). Population-attributable risks for oral cavity cancer were 78.6% for tobacco smoking, 7.3% for alcohol drinking and 80.7% for tobacco and/or alcohol consumption. These results indicate that regular oral check-ups should be targeted at smokers and heavy drinkers, and that prevention efforts should be focused on smoking cessation.

  19. Appropriating Written French: Literacy Practices in a Parisian Elementary Classroom

    ERIC Educational Resources Information Center

    Rockwell, Elsie

    2012-01-01

    In this article, I examine French language instruction in an elementary classroom serving primarily children of Afro-French immigrants in Paris. I show that a prevalent French language ideology privileges written over oral expression and associates full mastery of written French with rational thought and full inclusion in the French polity. This…

  20. How deaf are French speakers to stress?

    PubMed

    Michelas, Amandine; Frauenfelder, Ulrich Hans; Schön, Daniele; Dufour, Sophie

    2016-03-01

    This event-related potential study examined whether French listeners use stress at a phonological level when discriminating between stressed and unstressed words in their language. Participants heard five words and made same/different decisions about the final word (male voice) with respect to the four preceding words (different female voices). Compared to the first four context words, the target word was (i) phonemically and prosodically identical (/ʃu/-/ʃu/; control condition), (ii) phonemically identical but differing in the presence of a primary stress (/ʃu'/-/ʃu/), (iii) prosodically identical but phonemically different (/ʃo/-/ʃu/), or (iv) both phonemically and prosodically different (/ʃo'/-/ʃu/). Crucially, differences on the P200 and the following N200 components were observed for the /ʃu'/-/ʃu/ and the /ʃo/-/ʃu/ conditions compared to the /ʃu/-/ʃu/ control condition. Moreover, on the N200 component more negativity was observed for the /ʃo/-/ʃu/ condition compared to the /ʃu'/-/ʃu/ conditions, while no difference emerged between these two conditions on the earlier P200 component. Crucially, the results suggest that French listeners are capable of creating an abstract representation of stress. However, as they receive more input, participants react more strongly to phonemic than to stress information.

  1. Direct Mapping of Acoustics to Phonology: On the Lexical Encoding of Front Rounded Vowels in L1 English-L2 French Acquisition

    ERIC Educational Resources Information Center

    Darcy, Isabelle; Dekydtspotter, Laurent; Sprouse, Rex A.; Glover, Justin; Kaden, Christiane; McGuire, Michael; Scott, John H. G.

    2012-01-01

    It is well known that adult US-English-speaking learners of French experience difficulties acquiring high /y/-/u/ and mid /oe/-/[openo]/ front vs. back rounded vowel contrasts in French. This study examines the acquisition of these French vowel contrasts at two levels: phonetic categorization and lexical representations. An ABX categorization task…

  2. Des stereotypes de la France et des Francais chez des etudiants mexicains (Some Stereotypes of France and the French Held by Mexican Students).

    ERIC Educational Resources Information Center

    Pugibet, Veronica

    1983-01-01

    The origins and functions of stereotypes are discussed, a classroom study of Mexican students' perceptions of the French and French culture based on their responses to French advertising and cartoons is reported, and implications for instruction and teacher behavior to change existing stereotypes are outlined. (MSE)

  3. Performance Testing of PCR Assay in Blood Samples for the Diagnosis of Toxoplasmic Encephalitis in AIDS Patients from the French Departments of America and Genetic Diversity of Toxoplasma gondii: A Prospective and Multicentric Study

    PubMed Central

    Ajzenberg, Daniel; Lamaury, Isabelle; Demar, Magalie; Vautrin, Cyrille; Cabié, André; Simon, Stéphane; Nicolas, Muriel; Desbois-Nogard, Nicole; Boukhari, Rachida; Riahi, Homayoun; Dardé, Marie-Laure; Massip, Patrice; Dupon, Michel; Preux, Pierre-Marie; Labrunie, Anaïs; Boncoeur, Marie-Paule

    2016-01-01

    Background Toxoplasmic encephalitis in patients with AIDS is a life-threatening disease mostly due to reactivation of Toxoplasma gondii cysts in the brain. The main objective of this study was to evaluate the performance of real-time PCR assay in peripheral blood samples for the diagnosis of toxoplasmic encephalitis in AIDS patients in the French West Indies and Guiana. Methodology/Principal Findings Adult patients with HIV and suspicion of toxoplasmic encephalitis with start of specific antitoxoplasmic therapy were included in this study during 40 months. The real-time PCR assay targeting the 529 bp repeat region of T. gondii was performed in two different centers for all blood samples. A Neighbor-Joining tree was reconstructed from microsatellite data to examine the relationships between strains from human cases of toxoplasmosis in South America and the Caribbean. A total of 44 cases were validated by a committee of experts, including 36 cases with toxoplasmic encephalitis. The specificity of the PCR assay in blood samples was 100% but the sensitivity was only 25% with moderate agreement between the two centers. Altered level of consciousness and being born in the French West Indies and Guiana were the only two variables that were associated with significantly decreased risk of false negative results with the PCR assay. Conclusion/Significance Our results showed that PCR sensitivity in blood samples increased with severity of toxoplasmic encephalitis in AIDS patients. Geographic origin of patients was likely to influence PCR sensitivity but there was little evidence that it was caused by differences in T. gondii strains. Trial Registration ClinicalTrials.gov NCT00803621 PMID:27355620

  4. Cross-Cultural Adaptation of the CHAMPS Questionnaire in French Canadians with COPD.

    PubMed

    Mak, Susanne; Soicher, Judith E; Mayo, Nancy E; Wood-Dauphinee, Sharon; Bourbeau, Jean

    2016-01-01

    Physical activity is difficult to measure in individuals with COPD. The Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire demonstrated strong clinometric properties when used with the elderly and with those affected by chronic disease. Study objectives were to translate, culturally adapt the CHAMPS into French, and reexamine its test-retest reliability and construct validity in French and English Canadians with COPD. This paper presents the cross-cultural adaptation of the CHAMPS; results of its clinometric testing will be described in another article. The CHAMPS examines the degree of physical activity performed in a typical week through two summary scales, caloric expenditure and activity frequency. The CHAMPS was only in English; thus, a cross-cultural adaptation was needed to translate the CHAMPS into French for use in French Canadians with COPD. Cross-cultural adaptation consisted of forward and back translation, with expert review at each stage of translation: minor inconsistencies were uncovered and rectified. Five French participants with COPD completed the finalized Canadian French CHAMPS and participated in cognitive debriefing; no problematic items were identified. A structured and stepwise, cross-cultural adaptation process produced the Canadian French CHAMPS, with items of equivalent meaning to the English version, for use in French Canadians with COPD.

  5. Evaluation of the French Immersion Weekends, French Centre, University of Calgary, 1979-80.

    ERIC Educational Resources Information Center

    Klinck, Patricia

    Four French immersion weekends for continuing education students at the University of Calgary were evaluated. Each weekend involved recreational activities for twenty students and four French-speaking monitors at one of two recreational retreats near Calgary. The purpose of the program was to promote fluency in French by encouraging its use in a…

  6. "What Are We Black Men Who Are Called French?"

    ERIC Educational Resources Information Center

    LeSeur, Geta J.

    This teachers guide for an eight-week unit on 20th century French African literature, is intended for use with heterogeneously grouped juniors and seniors. The unit is one in a series by the Public Education Religion Studies Center at Wright State University. The guide represents a thematic approach to literature well suited to team teaching with…

  7. Why Are Your Students Sleeping through the French Revolution?

    ERIC Educational Resources Information Center

    Joseph, Brad

    2008-01-01

    The French Revolution can be a difficult subject to teach. Students often struggle to relate to events that happened more than two hundred years ago in France. In this article, the author suggests three key causes for the failure of the revolution that social studies teachers can focus on when teaching this topic. He also provides several stories…

  8. Expressive English Syntax in Canadian French-Immersion School Children.

    ERIC Educational Resources Information Center

    Simpson, Janet P.; Stewart, James Monroe

    1981-01-01

    Study results indicated that there were no lasting differences in the English expressive syntactic skills of 57 junior kindergarten through third-grade English-speaking children enrolled in a French immersion program, relative to the English monolingual subjects who made up the normative data. (Author/CM)

  9. French Immersion for English Language Learners?: Kindergarten Teachers' Perspectives

    ERIC Educational Resources Information Center

    Mady, Callie

    2016-01-01

    Given the increasingly diverse, multilingual student body in Canada, the call for increased inclusion in education, and in light of research highlighting the potential for inclusion in French immersion (FI) to be limited by gatekeepers, this study examines the beliefs of kindergarten teachers regarding the inclusion of English language learners in…

  10. Negritude: A New Dimension in the French Classroom

    ERIC Educational Resources Information Center

    Warner, Keith Q.

    1974-01-01

    Discusses how the study of negritude writings, put in the proper perspective, can help to show the futile nature of racial discrimination, the beauty of African and Caribbean culture, the contribution of the black man to world civilization, and the universality of the French language. (Author/JM)

  11. Prosodically-Conditioned Variability in Children's Production of French Determiners

    ERIC Educational Resources Information Center

    Demuth, Katherine; Tremblay, Annie

    2008-01-01

    Researchers have long noted that children's grammatical morphemes are variably produced, raising questions about when and how grammatical competence is acquired. This study examined the spontaneous production of determiners by two French-speaking children aged 1 ; 5-2 ; 5. It found that determiners were produced earlier with monosyllabic words,…

  12. English in the French Workplace: Realism and Anxieties

    ERIC Educational Resources Information Center

    Deneire, Marc

    2008-01-01

    The adoption of English as a corporate language in an increasingly large number of French companies has provoked various reactions ranging from enthusiastic embrace to strong rejection based on anxiety and cultural protectionism. This paper is an attempt to understand these reactions based on a stratified study of the extent to which English has…

  13. Voicing and Devoicing Assimilation of French /s/ and /z/

    ERIC Educational Resources Information Center

    Abdelli-Beruh, Nassima B.

    2012-01-01

    The present acoustic-phonetic study explores whether voicing and devoicing assimilations of French fricatives are equivalent in magnitude and whether they operate similarly (i.e., complete vs. gradient, obligatory vs. optional, regressive vs. progressive). It concurrently assesses the contribution of speakers' articulation rate to the proportion…

  14. Perceptual Processing of Partially and Fully Assimilated Words in French

    ERIC Educational Resources Information Center

    Snoeren, Natalie D.; Segui, Juan; Halle, Pierre A.

    2008-01-01

    Models of speech perception attribute a different role to contextual information in the processing of assimilated speech. This study concerned perceptual processing of regressive voice assimilation in French. This phonological variation is asymmetric in that assimilation is partial for voiced stops and nearly complete for voiceless stops. Two…

  15. Perceptions of French Fluency in Second Language Speech Production

    ERIC Educational Resources Information Center

    Préfontaine, Yvonne

    2013-01-01

    Recent literature in second language (L2) perceived fluency has focused on English as a second language, with a primary reliance on impressions from native-speaker judges, leaving learners' self-perceptions of speech production unexplored. This study investigates the relationship between learners' and judges' perceptions of French fluency under…

  16. Gender Attribution and Gender Agreement in French Williams Syndrome

    ERIC Educational Resources Information Center

    Boloh, Yves; Ibernon, Laure; Royer, Stephanie; Escudier, Frederique; Danillon, Aurelia

    2009-01-01

    Previous studies on grammatical gender in French individuals with Williams syndrome (WS) have led to conflicting findings and interpretations regarding keys abilities--gender attribution and gender agreement. New production data from a larger SW sample (N = 24) showed that gender attribution scores in SW participants exactly mirrored those of…

  17. French Tolerance for Grammatical Errors Made by Americans.

    ERIC Educational Resources Information Center

    Piazza, Linda Gaylord

    1980-01-01

    Article investigates Frenchpersons' tolerance for grammatical errors typical of Americans learning French and attempts to establish priorities for correcting errors in classroom. Study looks at degree to which errors interfered with comprehensibility, irritation caused by errors, whether errors were more tolerated in speaking or writing, and rank…

  18. Implicit and Explicit Recasts in L2 Oral French Interaction

    ERIC Educational Resources Information Center

    Erlam, Rosemary; Loewen, Shawn

    2010-01-01

    This laboratory-based study of second- and third-year American university students learning French examines the effectiveness of implicit and explicit corrective feedback on noun-adjective agreement errors. The treatment consisted of one hour of interactive tasks. Implicit feedback was operationalized as a single recast with interrogative…

  19. Persistent Stress "Deafness": The Case of French Learners of Spanish

    ERIC Educational Resources Information Center

    Dupoux, Emmanuel; Sebastian-Galles, Nuria; Navarrete, Eduardo; Peperkamp, Sharon

    2008-01-01

    Previous research by Dupoux et al. [Dupoux, E., Pallier, C., Sebastian, N., & Mehler, J. (1997). A destressing "deafness" in French? "Journal of Memory Language" 36, 406-421; Dupoux, E., Peperkamp, S., & Sebastian-Galles (2001). A robust method to study stress' deafness. "Journal of the Acoustical Society of America" 110, 1608-1618.] found that…

  20. Reproductive health and pregnancy outcomes among French gulf war veterans

    PubMed Central

    Verret, Catherine; Jutand, Mathe-Aline; De Vigan, Catherine; Bégassat, Marion; Bensefa-Colas, Lynda; Brochard, Patrick; Salamon, Roger

    2008-01-01

    Background Since 1993, many studies on the health of Persian Gulf War veterans (PGWVs) have been undertaken. Some authors have concluded that an association exists between Gulf War service and reported infertility or miscarriage, but that effects on PGWV's children were limited. The present study's objective was to describe the reproductive outcome and health of offspring of French Gulf War veterans. Methods The French Study on the Persian Gulf War (PGW) and its Health Consequences is an exhaustive cross-sectional study on all French PGWVs conducted from 2002 to 2004. Data were collected by postal self-administered questionnaire. A case-control study nested in this cohort was conducted to evaluate the link between PGW-related exposures and fathering a child with a birth defect. Results In the present study, 9% of the 5,666 Gulf veterans who participated reported fertility disorders, and 12% of male veterans reported at least one miscarriage among their partners after the PGW. Overall, 4.2% of fathers reported at least one child with a birth defect conceived after the mission. No PGW-related exposure was associated with any birth defect in children fathered after the PGW mission. Concerning the reported health of children born after the PGW, 1.0% of children presented a pre-term delivery and 2.7% a birth defect. The main birth defects reported were musculoskeletal malformations (0.5%) and urinary system malformations (0.3%). Birth defect incidence in PGWV children conceived after the mission was similar to birth defect incidence described by the Paris Registry of Congenital Malformations, except for Down syndrome (PGWV children incidence was lower than Registry incidence). Conclusion This study did not highlight a high frequency of fertility disorders or miscarriage among French PGW veterans. We found no evidence for a link between paternal exposure during the Gulf War and increased risk of birth defects among French PGWV children. PMID:18442369

  1. Tracing sediment sources during floods using Diffuse Reflectance Infrared Fourier Transform Spectrometry (DRIFTS): A case study in a highly erosive mountainous catchment (Southern French Alps)

    NASA Astrophysics Data System (ADS)

    Poulenard, J.; Legout, C.; Némery, J.; Bramorski, J.; Navratil, O.; Douchin, A.; Fanget, B.; Perrette, Y.; Evrard, O.; Esteves, M.

    2012-01-01

    SummaryIn mountainous catchments, large quantities of sediment are exported within very short periods leading to numerous environmental problems (e.g. reservoir siltation). The origin of suspended sediment during two distinct floods was determined by conducting an original fingerprinting method coupling Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) and a chemometric technique (i.e. Partial Least Squares - PLS-analysis). Samples of the potential sediment sources were collected in badland areas developed on various substrates (i.e. molasse, marly limestones, black marls and gypsum) in the Galabre 20 km 2-catchment located in the French Southern Alps. DRIFTS spectra provided a way to discriminate between the different potential sediment sources. Furthermore, the use of mid-infrared spectra allowed the direct quantification of the gypsum proportion in sediment. This contribution was systematically null at the catchment outlet because of the rapid dissolution of gypsum in the river. A PLS model was then constructed to estimate the contribution of the three other potential sources to the sediment flux during the floods. This model was developed and validated using a set of 45 "experimental" samples that were prepared in the laboratory in order to contain various proportions of the three remaining sources. By introducing DRIFTS spectra into the PLS model, we could predict the proportions of those sources in the mixed 'experimental' samples with a confidence interval of ca. ±10%. The model was then applied to the sediment collected during the two selected floods in order to outline their origin. Black marls provided the highest contribution of sediment during both events, but the analysis also revealed a significant contribution of molasse. Results also showed the remobilisation of sediment originated from molassic substrates that deposited on the riverbed during a preceding event. Opportunities for improvement and further use of this method as an

  2. Effectiveness and tolerance of single tablet versus once daily multiple tablet regimens as first-line antiretroviral therapy - Results from a large french multicenter cohort study

    PubMed Central

    Cotte, Laurent; Ferry, Tristan; Pugliese, Pascal; Valantin, Marc-Antoine; Allavena, Clotilde; Cabié, André; Poizot-Martin, Isabelle; Rey, David; Duvivier, Claudine; Cheret, Antoine; Dellamonica, Pierre; Pradat, Pierre; Parienti, Jean-Jacques

    2017-01-01

    Objectives Pill burden during antiretroviral treatment (ART) is associated with worse adherence and impaired virological suppression. We compared the effectiveness, tolerance, and persistence on treatment of single tablet regimens (STRs) with non-STR once-daily regimens in patients receiving first-line ART. Methods Retrospective analysis of naïve HIV-1 infected patients prospectively enrolled in the French Dat’AIDS cohort and initiating first-line ART with STRs or once-daily non-STRs from 2004 to 2013. The primary outcome was time to treatment discontinuation defined by any change in the treatment regimen. STR and non-STR groups were compared controlling for baseline risk factors by inverse probability weighted treatment Cox analysis (IPWT) and propensity-score matching (PSM). Results Overall, 3212 patients (STR 499, non-STR 2713) were included. Median time to treatment discontinuation was shorter in non-STR patients than in STR patients, both in the IPWT (HR = 0.61, p<0.0001) and the PSM cohort (HR = 0.55, p<0.0001). This difference disappeared when censoring ART modification for simplification, both in the IPWT (HR = 0.97, p = 0.65) and the PSM cohort (HR = 0.91, p = 0.33). A lower rate of virological failure was observed with STRs than with non-STRs in both cohorts (HR = 0.23; p = 0.002 and HR = 0.22, p = 0.003, respectively). A lower rate of treatment modification for adverse event was observed with non-STRs in the IPWT cohort (HR = 1.46, p<0.0001), but not in the PSM cohort (HR = 1.22, p = 0.11). Conclusion First-line therapy with STRs was associated with a longer time to treatment discontinuation than with non-STRs. However, when ART modification for simplification was not considered as a failure, STRs and non-STRs were similar. PMID:28152047

  3. Trace element distribution in silicate phases from the cumulate mafic xenoliths of Puy Beaunit (French Massif Central): A LA-ICP-MS study

    NASA Astrophysics Data System (ADS)

    Demaiffe, D.; Berger, J.; Femenias, O.; Coussaert, N.

    2003-04-01

    A large diversity of xenoliths is present in the scoria cones of the quaternary Puy Beaunit (French Massif Central). Mafic xenoliths are abundant, they are mainly gabbronorites with minor pyroxenites and anorthositic gabbros. It has been shown recently that they derived from a deep layered complex emplaced at the crust-mantle boundary during Late Permian (257+/- 6Ma). These rocks still partly show magmatic structures. However, sub-solidus recrystallisation and pyrometamorphic overprinting (while the xenoliths were taken up by the lava) have partly blurred the magmatic primary textures. The xenoliths now have polygonal and coronitic textures, so intercumulus phases cannot be easily identified. The abundance of orthopyroxene (generally missing in alkaline series), the low content of REE and trace elements and the nearly flat spidergram profiles suggest that these xenoliths are of subalkaline affinity. They commonly show mm- to cm- scale layering indicative of a cumulate origin. Positive (in whole rock plagioclase-rich gabbros) and negative (in pyroxene-rich gabbros) Eu anomalies also argue for a cumulate origin. The trace element contents (REE, Zr, Hf, Rb, Sr, Nb, Ta, Ba) of the main silicate phases (plagioclase, orthopyroxene, clinopyroxene and the very fine-grained coronites) have been obtained by LA-ICP-MS. Two processes control the REE content of these mafic xenoliths: 1) the degree of differentiation, which is indicated by the Mg# of the cumulus orthopyroxene; 2) the proportion of trapped interstitial liquid which is indicated by the content of highly incompatible elements (U, Th, Zr and Rb) in whole rock analyses. Plagioclases and orthopyroxenes have relatively low REE contents compared to clinopyroxene and coronitic association suggesting that they are the cumulus phases. High REE and trace element contents of clinopyroxenes and of the very fine-grained coronites point to an intercumulus origin. Moreover, in situ REE patterns show that the very fine

  4. Panton-valentine leukocidin-positive and toxic shock syndrome toxin 1-positive methicillin-resistant Staphylococcus aureus: a French multicenter prospective study in 2008.

    PubMed

    Robert, Jérôme; Tristan, Anne; Cavalié, Laurent; Decousser, Jean-Winoc; Bes, Michèle; Etienne, Jerome; Laurent, Frédéric

    2011-04-01

    The epidemiology of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) differs from country to country. We assess the features of the ST80 European clone, which is the most prevalent PVL-positive CA-MRSA clone in Europe, and the TSST-1 ST5 clone that was recently described in France. In 2008, all MRSA strains susceptible to fluoroquinolones and gentamicin and resistant to fusidic acid that were isolated in 104 French laboratories were characterized using agr alleles, spa typing, and the staphylococcal cassette chromosome mec element and PCR profiling of 21 toxin genes. Three phenotypes were defined: (i) kanamycin resistant, associated with the ST80 clone; (ii) kanamycin and tobramycin resistant, associated with the ST5 clone; and (iii) aminoglycoside susceptible, which was less frequently associated with the ST5 clone. Among the 7,253 MRSA strains isolated, 91 (1.3%) were ST80 CA-MRSA (89 phenotype 1) and 190 (2.6%) were ST5 CA-MRSA (146 phenotype 2, 42 phenotype 3). Compared to the latter, ST80 CA-MRSAs were more likely to be community acquired (80% versus 46%) and found in young patients (median age, 26.0 years versus 49.5 years) with deep cutaneous infections (48% versus 6%). They were less likely to be tetracycline susceptible (22% versus 85%) and to be isolated from respiratory infections (6% versus 27%). The TSST-1 ST5 clone has rapidly emerged in France and has become even more prevalent than the ST80 European clone, whose prevalence has remained stable. The epidemiological and clinical patterns of the two clones differ drastically. Given the low prevalence of both among all staphylococcal infections, no modification of antibiotic recommendations is required yet.

  5. Construct validity of the Social Physique Anxiety Scale in a French adolescent sample.

    PubMed

    Maïano, Christophe; Morin, Alexandre J S; Eklund, Robert C; Monthuy-Blanc, Johana; Garbarino, Jean-Marie; Stephan, Yannick

    2010-01-01

    We conducted a series of studies to investigate the psychometric properties of the Social Physique Anxiety Scale (SPAS; Hart, Leary, & Rejeski, 1989) among a total sample of 1,563 nonclinical French adolescents. The, first study provided support for the item content of the preliminary version of the French SPAS for adolescents. Then, the second study supported the convergent validity of the English and French version of the SPAS. Finally, Studies 3 to 6 provided support for the factor validity, measurement invariance (across genders, age groups and samples), latent mean structure invariance (across age category and samples), reliability, convergent validity, and criterion-related validity of a 7-item version of the SPAS.

  6. Cross-border reproductive care for law evasion: a qualitative study into the experiences and moral perspectives of French women who go to Belgium for treatment with donor sperm.

    PubMed

    Van Hoof, Wannes; Pennings, Guido; De Sutter, Petra

    2015-01-01

    One consequence of the legal diversity in Europe is that legal restrictions on treatments can be evaded by going abroad. Many French lesbian couples and single women are crossing the border to Belgium because they are denied access to treatments with donor sperm at home. This is the first qualitative research study into the experiences and moral perspectives of these women. Between June 2012 and May 2013, 11 lesbian couples and 2 single women were recruited at the department of reproductive medicine at Ghent University Hospital. The data from the semi-structured interviews was analysed using inductive thematic analysis. The results show that these women face several additional challenges to the already difficult process of cross-border treatment. Before they can start the treatment, they can only obtain information from the internet or from stories of friends who also went abroad for treatment with donor sperm. During the treatment, they need to find local clinics or physicians to monitor their cycle. Several women managed to game the French system to ensure partial reimbursement for their treatment when they were successful in finding a physician who was willing to prescribe drugs and perform tests. Most women had difficulties justifying their absence from work. In general these women felt that they were discriminated against and that their rights were not protected because of who they are. In that regard, the lack of legal recognition of the genetically unrelated partner in their country was particularly hard to cope with for the lesbian couples. These women have to develop many different strategies to deal with the difficulties they face during cross-border reproductive care. It is concluded that it is very important that they find a physician who is willing to support them in their 'baby project'.

  7. Development of English and French Language and Literacy Skills in EL1 and EL French Immersion Students in the Early Grades

    ERIC Educational Resources Information Center

    Au-Yeung, Karen; Hipfner-Boucher, Kathleen; Chen, Xi; Pasquarella, Adrian; D'Angelo, Nadia; Deacon, S. Hélène

    2015-01-01

    In this article, we report two studies that compared the development of English and French language and literacy skills in French immersion students identified as native English speakers (EL1s) and English learners (ELs). In study 1, 81 EL1s and 147 ELs were tested in the fall and spring terms of grade 1. The EL1s and ELs had similar outcomes and…

  8. Validation of the French version of the BACS (the brief assessment of cognition in schizophrenia) among 50 French schizophrenic patients.

    PubMed

    Bralet, Marie-Cécile; Falissard, Bruno; Neveu, Xavier; Lucas-Ross, Margaret; Eskenazi, Anne-Marie; Keefe, Richard S E

    2007-09-01

    Schizophrenic patients demonstrate impairments in several key dimensions of cognition. These impairments are correlated with important aspects of functional outcome. While assessment of these cognition disorders is increasingly becoming a part of clinical and research practice in schizophrenia, there is no standard and easily administered test battery. The BACS (Brief Assessment of Cognition in Schizophrenia) has been validated in English language [Keefe RSE, Golberg TE, Harvey PD, Gold JM, Poe MP, Coughenour L. The Brief Assessment of Cognition in Schizophrenia: reliability, sensibility, and comparison with a standard neurocognitive battery. Schizophr. Res 2004;68:283-97], and was found to be as sensitive to cognitive dysfunction as a standard battery of tests, with the advantage of requiring less than 35 min to complete. We developed a French adaptation of the BACS and this study tested its ease of administration and concurrent validity. Correlation analyses between the BACS (version A) and a standard battery were performed. A sample of 50 stable schizophrenic patients received the French Version A of the BACS in a first session, and in a second session a standard battery. All the patients completed each of the subtests of the French BACS . The mean duration of completion for the BACS French version was 36 min (S.D.=5.56). A correlation analysis between the BACS (version A) global score and the standard battery global score showed a significant result (r=0.81, p<0.0001). The correlation analysis between the BACS (version A) sub-scores and the standard battery sub-scores showed significant results for verbal memory, working memory, verbal fluency, attention and speed of information processing and executive functions (p<0.001) and for motor speed (p<0.05). The French Version of the BACS is easier to use in French schizophrenic patients compared to a standard battery (administration shorter and completion rate better) and its good psychometric properties suggest

  9. French space programmes related to global change

    NASA Astrophysics Data System (ADS)

    Fellous, J. L.; Ratier, A.

    The guidelines of the national and cooperative environmental programmes conducted by CNES are complementarity with third agencies' programmes, synergism between scientific and application projects, and promotion of innovative concepts likely to meet the requirements of the World Climate Research and International Geosphere-Biosphere Programmes. While the on-going SPOT series is to provide imagery of land surfaces until 2000, the TOPEX/POSEIDON altimetric mission is being developed by NASA and CNES for launch in mid-1992 in phase with the WOCE intensive field experiments. The design study of the AVISO ocean data system, and the development on behalf of ESA of the ERS-1-dedicated CERSAT facility are consolidating the French effort in space oceanography. Two other research space missions are studied by CNES and French laboratories. BEST, whose phase A study is nearing completion, is a low-altitude, low-inclination, GEWEX-dedicated mission for the investigation of the water and energy cycle in the tropics, with a target launch date in the late 1990's. The phase A study of GLOBSAT, a more IGBP-oriented mission concept, has just been initiated. The first objective of this mission in polar orbit considered for launch around 1997, is to collect comprehensive data sets needed to document key processes related to cloud/radiation interaction, stratospheric/tropospheric chemistry and dynamics of continental and marine ecosystems. The second objective is to start monitoring long-term trends of parameters required to close global budgets of carbon and ozone. The analysis of this space mission concept is conducted in parallel with the development of instruments of opportunity to be flown onboard foreign satellites, and of airborne sensors, either precursor to space instruments or designed for process studies and validation of space data.

  10. A Mini-Film on French Kinesics.

    ERIC Educational Resources Information Center

    Walz, Joel

    This paper describes a silent film made by the author which illustrates various French gestures. The format is Super 8, and the film lasts five minutes. The script is given, along with an English translation. The story concerns several French students at an outdoor cafe wondering about one of their friends. The conversation includes 10 typical…

  11. French-African Cultures: A Resource Unit.

    ERIC Educational Resources Information Center

    Forbes, Barbara

    This resource unit concerns French-African cultures and their influence on other cultures. The materials may be incorporated into Levels 3, 4, and 5 French classes. Topics in the outline include environmental aspects; historical background; and cultural differences expressed in Senegal, Guinee, Mali, Cote d'Ivoire, Haute Volta, Togo, Dahomey,…

  12. Les affaires "en francais" (Business "In French").

    ERIC Educational Resources Information Center

    Sanko, Helene N.

    1993-01-01

    A French brochure entitled "700 Current Words for Business" was developed to familiarize the business community with modern French business vocabulary and avoid intrusion of terminology from other languages. Some terms are neologisms. Translations from Latin, Japanese, and English illustrate the etymology and morphological patterns of…

  13. French Romanticism and Napoleon's "Geometric Men."

    ERIC Educational Resources Information Center

    Cole, Robert A.

    1982-01-01

    French intellectual thought changed during the Napoleonic Era. The effects of the Enlightenment philosophers, the French Revolution, the Industrial Revolution, and Romanticism on the development of Napoleon's philosophical outlook are used to illustrate the changes occurring in France as a whole in the early nineteenth century. (AM)

  14. Metropolitan French: Familiarization & Short-Term Training.

    ERIC Educational Resources Information Center

    Iszkowski, Marie-Charlotte

    The U.S. Department of State's Foreign Service Institute French Familiarization and Short-Term (FAST) course for personnel working and living in France consists of 10 weeks of French language instruction combined with practical and cultural information. An introductory section outlines FAST course objectives and sample teaching techniques in…

  15. Syntactic Devices of Emphasis in Contemporary French.

    ERIC Educational Resources Information Center

    Hollerbach, Wolf

    A device of emphasis in French syntax is defined as a construction of syntactic paraphrase whose function is to make certain parts of a sentence stand out for purposes of contrast, clarification, differentiation, or because a given element is considered important. These devices exist in French because of the lack of a phonemic stress system, and…

  16. Vowel Aperture and Syllable Segmentation in French

    ERIC Educational Resources Information Center

    Goslin, Jeremy; Frauenfelder, Ulrich H.

    2008-01-01

    The theories of Pulgram (1970) suggest that if the vowel of a French syllable is open then it will induce syllable segmentation responses that result in the syllable being closed, and vice versa. After the empirical verification that our target French-speaking population was capable of distinguishing between mid-vowel aperture, we examined the…

  17. Le Francais Courant (Contemporary French), Part II.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course has been developed basically within the limits of Units 4-6 of "A-LM French: Level 1", second edition. The primary objectives are to develop French vocabulary relative to the family, home, transportation, and foods by continuing to work with short dialogues based on everyday, teenage experiences. While reviewing previously studied…

  18. Act Up-Paris: French Lessons

    ERIC Educational Resources Information Center

    Nakayama, Thomas K.

    2012-01-01

    The francophone world has always been at the center of the HIV/AIDS epidemic. From the mythical (French Canadian) "patient zero," Gaetan Dugas, to Rock Hudson's flight to Paris for medical treatment and the blaming of Haiti for AIDS, as well as the close relationships between Belgian and French and their former African colonies,…

  19. French Higher Education: A Cartoon Essay

    ERIC Educational Resources Information Center

    Hall, Matthew Henry

    2012-01-01

    In this cartoon essay, the author shares his experience from a travel to Paris to see the French higher education system. From his travel, he learned that in France, "degree" inflation may be an issue, but not grade inflation. On the flight home, the author reflects how French and American academics answer one question about the state of…

  20. The French Regions and Their Social Health

    ERIC Educational Resources Information Center

    Jany-Catrice, Florence

    2009-01-01

    In this article, a new indicator designed to capture the multidimensionality of the social health of the French regions is put to the test. Drawing on regional data for 2004, this indicator of social health (ISH) sheds new light on the social performance of the French regions. The worst performers are the highly urbanised regions, whereas others,…

  1. Lafayette School District: French Immersion Program

    ERIC Educational Resources Information Center

    Boudreaux, Nicole

    2007-01-01

    From 1969 to the late 1980's, most French programs in schools were based on a traditional foreign language instructional model, usually offering 30 minutes a day of French language instruction in elementary grades, increasing to 50 minutes a day in middle school. Contingent on funding and political swings over time, programs expanded from…

  2. Commercial French Radio in the Classroom.

    ERIC Educational Resources Information Center

    Melpignano, Richard J.

    1980-01-01

    Describes several techniques for implementing commercial radio to improve listening comprehension skills in the foreign language student. Canadian radio, accessible to much of the northern United States, brings news, weather, and sports, in French, to the student of French and provides major components for sharpening comprehension skills. (PJM)

  3. Why Learn French for Business in 2001?

    ERIC Educational Resources Information Center

    Maratier-Declety, Guilhene

    This essay makes the case for why it is worth learning French for business purposes, even though it is acknowledged that English is increasingly the lingua franca of international business, science, technology, and the Internet. It is asserted that French is still the dominant language in some important markets, and being able to conduct business…

  4. The French Language in the Americas.

    ERIC Educational Resources Information Center

    Valdman, Albert, Ed.

    The annual bulletin of the French 8 section of the Annual Meeting of the Modern Language Association of America is presented with the texts of papers read at both the 1969 and 1970 sessions. The 1970 papers, in French, include Jean Louis Darbelnet's "Etude Sociolinguistique des contacts entre 1'Anglais et le Francais au Canada et en…

  5. Business Letter Writing: English, French, and Japanese.

    ERIC Educational Resources Information Center

    Jenkins, Susan; Hinds, John

    1987-01-01

    Examination of business letters in English, French, and Japanese, focusing on prescriptive accounts in the respective languages, found that, despite amazingly similar surface characteristics, American business letters were reader-oriented, French business letters were writer-oriented, and Japanese business letters were oriented to the space…

  6. Radical Reform of the French University System

    ERIC Educational Resources Information Center

    Bereziat, Gilbert

    2008-01-01

    The French university system is in crisis. After its dismantlement during the French revolution, its rebirth was progressive under the third republic (1871-1945). But it was only after 1968 that the current universities developed, with an autonomy that is strictly supervised by the state. Since 1986 all experiments at modernizing the management of…

  7. French Adaptation of the Narcissistic Personality Inventory in a Belgian French-Speaking Sample.

    PubMed

    Braun, Stéphanie; Kempenaers, Chantal; Linkowski, Paul; Loas, Gwenolé

    2016-01-01

    The Narcissistic Personality Inventory (NPI) is the most widely used self-report scale to assess the construct of narcissism, especially in its grandiosity expression. Over the years, several factor models have been proposed in order to improve the understanding of the multidimensional aspect of this construct. The available data are heterogeneous, suggesting one to at least seven factors. In this study, we propose a French adaptation of the NPI submitted to a sample of Belgian French-speaking students (n = 942). We performed a principal component analysis on a tetrachoric correlation matrix to explore its factor structure. Unlike previous studies, our study shows that a first factor explains the largest part of the variance. Internal consistency is excellent and we reproduced the sex differences reported when using the original scale. Correlations with social desirability are taken into account in the interpretation of our results. Altogether, the results of this study support a unidimensional structure for the NPI using the total score as a self-report measure of the Narcissistic Personality Disorder in its grandiose form. Future studies including confirmatory factor analysis and gender invariance measurement are also discussed.

  8. French Adaptation of the Narcissistic Personality Inventory in a Belgian French-Speaking Sample

    PubMed Central

    Braun, Stéphanie; Kempenaers, Chantal; Linkowski, Paul; Loas, Gwenolé

    2016-01-01

    The Narcissistic Personality Inventory (NPI) is the most widely used self-report scale to assess the construct of narcissism, especially in its grandiosity expression. Over the years, several factor models have been proposed in order to improve the understanding of the multidimensional aspect of this construct. The available data are heterogeneous, suggesting one to at least seven factors. In this study, we propose a French adaptation of the NPI submitted to a sample of Belgian French-speaking students (n = 942). We performed a principal component analysis on a tetrachoric correlation matrix to explore its factor structure. Unlike previous studies, our study shows that a first factor explains the largest part of the variance. Internal consistency is excellent and we reproduced the sex differences reported when using the original scale. Correlations with social desirability are taken into account in the interpretation of our results. Altogether, the results of this study support a unidimensional structure for the NPI using the total score as a self-report measure of the Narcissistic Personality Disorder in its grandiose form. Future studies including confirmatory factor analysis and gender invariance measurement are also discussed. PMID:28066299

  9. When pitch Accents Encode Speaker Commitment: Evidence from French Intonation.

    PubMed

    Michelas, Amandine; Portes, Cristel; Champagne-Lavau, Maud

    2016-06-01

    Recent studies on a variety of languages have shown that a speaker's commitment to the propositional content of his or her utterance can be encoded, among other strategies, by pitch accent types. Since prior research mainly relied on lexical-stress languages, our understanding of how speakers of a non-lexical-stress language encode speaker commitment is limited. This paper explores the contribution of the last pitch accent of an intonation phrase to convey speaker commitment in French, a language that has stress at the phrasal level as well as a restricted set of pitch accents. In a production experiment, participants had to produce sentences in two pragmatic contexts: unbiased questions (the speaker had no particular belief with respect to the expected answer) and negatively biased questions (the speaker believed the proposition to be false). Results revealed that negatively biased questions consistently exhibited an additional unaccented F0 peak in the preaccentual syllable (an H+!H* pitch accent) while unbiased questions were often realized with a rising pattern across the accented syllable (an H* pitch accent). These results provide evidence that pitch accent types in French can signal the speaker's belief about the certainty of the proposition expressed in French. It also has implications for the phonological model of French intonation.

  10. French Frigate Shoals reef health survey

    USGS Publications Warehouse

    Work, Thierry M.; Coles, Steve L.; Rameyer, Robert

    2002-01-01

    French Frigate Shoals consists of a large (31 nm) fringing reef partially enclosing a lagoon. A basalt pinnacle (La Perouse Pinnacle) arises approximately halfway between the two ends of the arcs of the fringing reefs. Tern Island is situated at the northern end of the lagoon and is surrounded by a dredged ship channel. The lagoon becomes progressively shallower from west to east and harbors a variety of marine life including corals, fish, marine mammals, and sea turtles (Amerson 1971). In 2000, an interagency survey of the northwestern Hawaiian Islands was done to document the fauna and flora in FFS (Maragos and Gulko, 2002). During that survey, 38 stations were examined, and 41 species of stony corals were documented, the most of any of the NW Hawaiian islands (Maragos and Gulko 2002). In some of these stations, corals with abnormalities were observed. The present study aimed to expand on the 2000 survey to evaluate the lesions in areas where they were documented.

  11. Lexique 2: a new French lexical database.

    PubMed

    New, Boris; Pallier, Christophe; Brysbaert, Marc; Ferrand, Ludovic

    2004-08-01

    In this article, we present a new lexical database for French: Lexique. In addition to classical word information such as gender, number, and grammatical category, Lexique includes a series of interesting new characteristics. First, word frequencies are based on two cues: a contemporary corpus of texts and the number of Web pages containing the word. Second, the database is split into a graphemic table with all the relevant frequencies, a table structured around lemmas (particularly interesting for the study of the inflectional family), and a table about surface frequency cues. Third, Lexique is distributed under a GNU-like license, allowing people to contribute to it. Finally, a metasearch engine, Open Lexique, has been developed so that new databases can be added very easily to the existing ones. Lexique can either be downloaded or interrogated freely from http://www.lexique.org.

  12. Leukaemia mortality around French nuclear sites.

    PubMed Central

    Hattchouel, J. M.; Laplanche, A.; Hill, C.

    1995-01-01

    This study was designed to investigate leukaemia mortality in the population under the age of 25 residing around the 13 French nuclear sites operating in 1985. In four geographical zones defined according to the distance from the site, 503 exposed communes were identified and followed up between 1968 and 1989. A total of 4,132,000 person-years of observation were accumulated. The number of leukaemia deaths observed (69) did not differ from the expected number (86.15) estimated according to national mortality statistics. There was no difference in the risks of leukaemia mortality according to sex, age, type of installation and no trend with an increasing distance from installations. PMID:7880754

  13. A Comparison of Nonmetric Temporal Path Analysis with Linear Models Approach Using Actual and Hypothetical French Placement Data.

    ERIC Educational Resources Information Center

    Luk, HingKwan; Jacobs, Lucy C.

    Two studies that compare the use of analysis of patterns in time (APT) (formerly non-metric temporal path analysis) and the linear models approach (LMA) are reported. In the first study, scores on the College Entrance Examination Board French Achievement Test (CEEBFAT), number of years of study of high school French (YHSF), and course achievement…

  14. Relationships of French and English Morphophonemic Orthographies to Word Reading, Spelling, and Reading Comprehension during Early and Middle Childhood

    ERIC Educational Resources Information Center

    Abbott, Robert D.; Fayol, Michel; Zorman, Michel; Casalis, Séverine; Nagy, William; Berninger, Virginia W.

    2016-01-01

    Two longitudinal studies of word reading, spelling, and reading comprehension identified commonalities and differences in morphophonemic orthographies--French (Study 1, n = 1,313) or English (Study 2, n = 114) in early childhood (Grade 2)and middle childhood (Grade 5). For French and English, statistically significant concurrent relationships…

  15. [Update on the epidemiology of malaria in French Guiana].

    PubMed

    Carme, B; Ardillon, V; Girod, R; Grenier, C; Joubert, M; Djossou, F; Ravachol, F

    2009-02-01

    The last study describing the epidemiology of malaria in French Guiana was published 20 years ago. Yet French Guiana in the Americas along with Mayotte in the Indian Ocean is the only French territory with persisting endemic malaria. The purpose of this study is to provide an update based on official malaria surveillance data as well as on information from hospital records and various field surveys that have been carried out in recent years. Due to recurrent problems in collecting thorough, continuous, and consistent data, exact determination of incidence by plasmodium species has always been difficult in French Guiana. These problems include not only the remote location of endemic areas and intense unpredictable migration patterns but also poor data collection methods that do not always ensure consistency and homogeneity. Another factor hindering thorough collection of conventional epidemiological data is the requirement for rapid effective treatment in remote regions. The overall incidence of malaria in French Guiana appears to have remained stable since the beginning of the decade with an average of 3,920 case reports per year for an incidence rate of 20 per thousand, noting that three fourths of the 206,000 inhabitants of French Guiana live outside of endemic areas. Overall involvement of P. falciparum and P. vivax appears to be equal with P. malariae accounting for only 2.6% of cases. Trends in recent years indicate an increase in the number of cases involving P. vivax especially in the eastern zones, i.e. in the Oyapock focus where annual incidences in children have reached up to 500 per thousand and in the whole region located between Saint Georges and Cayenne. Conversely a decrease in endemic levels has been observed in western areas, especially for P. falciparum in the upper and middle focuses of the Maroni. Most zones now causing problems are located near migration points, particularly in relation with clandestine gold panning activities. In the coastal

  16. Effects of consonantal context on perception of French rounded vowels by American English adults with and without French language experience

    NASA Astrophysics Data System (ADS)

    Levy, Erika S.; Strange, Winifred

    2002-05-01

    This study extended Gottfried's [J. Phonetics 12, 91-114 (1984)] investigation of the effects of learning French on AE listeners categorial discrimination of the contrasts involving Parisian French vowels /y/, /ø/, /u/, and /i/. Vowels were presented in /rabVp/ and /radVt/ bisyllables embedded in carrier phrases by three different speakers in an AXB discrimination task. Two groups were tested: proficient L2-French-speaking AE listeners (Exp) and non-French-speaking AE listeners (Inexp). Overall, the Exp group performed better than the Inexp group on /u-ø/, /y-i/, and /y-ø/ distinctions (mean errors: Exp=5%, Inexp=24%). However, for /u-y/, the groups did not differ (Exp=30% vs Inexp=24% errors). The findings may be explained by perceptual assimilation patterns, which are determined, in part, by consonantal context. The Inexp group confused /y/ with /i/ in bilabial context, but /y/ with /u/ in alveolar context, whereas the Exp group confused /y/ with /u/, in both contexts. For all contrasts, the Inexp group performed better in bilabial than in alveolar context (16% vs 32% errors), whereas no context effect was revealed for the Exp group. The results suggest that learning a foreign language includes learning its coarticulatory rules.

  17. Socio-emotional support in French hospitals: Effects on French nurses' and nurse aides' affective commitment.

    PubMed

    Ruiller, Caroline; Van Der Heijden, Beatrice I J M

    2016-02-01

    In spite of the differences in human resource management (HRM) practices between the non-profit health care sector and business life, the majority of health care sector research appears to be based on the HRM (for human resources management) blueprint for business life staff policy and practice. This study is aimed to better understand the impact of workplace social support in the context of French hospitals. Concrete, the first objective of this article comprises a thorough conceptualization and operationalization of workplace social support (i.e. both professional and personal social support). Data were collected in a French hospital among a sample of 62 respondents (for the qualitative part of our study), and among a sample of 171 health care professionals (nurses and nurse aids) (for the quantitative part of our study). Our outcomes indicate that, especially, personal support given by one's supervisor is strongly and positively related to nurses' and nurse aides' affective commitment. After a discussion about the outcomes, followed by some recommendations for future research, the article concludes with some practical implications for management in hospitals.

  18. [Human parasitoses in French Guiana].

    PubMed

    Carme, B

    2001-11-03

    MALARIA: This review summarises current knowledge of the epidemiological situation regarding parasitoses in French Guiana. Malaria is the most prevalent infection. The most common species is Plasmodium falciparum which is responsible for three quarters of all bouts of malaria. Plasmodium vivax is mostly present in endemic areas inhabited by Amerindian communities. Plasmodium malariae is rarer. CHAGAS' DISEASE, LEISHMAMIASIS AND TOXOPLASMOSIS: Four acute cases of cardiac Chagas' disease were observed between 1994 and 1996. These cases serve as a warning concerning the possible emergence of this type of parasitosis among the poor in Latin America. Cutaneous leishmaniasis is still highly endemic, with an incidence of about 2 cases per 1,000 inhabitants, which has remained essentially unchanged for 15 years. The identification of severe primary toxoplasmosis in immunocompetent individuals in recent years seems to be associated with an as yet poorly known, natural, Amazonian cycle. INTESTINAL PARASITOSES: Improvements in living conditions, hygiene and treatments are such that intestinal parasitoses, other than anguilluliasis, are no longer a major problem in the urban or coastal areas. The situation is very different in the central areas of the country and in the Amerindian and black half-cast communities, with high prevalences of ankylostomiasis (hookworm disease), anguilluliasis and amoebal disease (Entamoeba histolytica/E. dispar). OTHERS: Lymphatic filariasis is no longer endemic; tropical schistosomiasis and distomiasis have never been endemic. Parasitic pests (cutaneous larva migrans and insect or dust-mite ectoparasites) are more spectacular than severe, and constitute a classic "exotic" component of the spectrum of diseases in French Guiana.

  19. DRIAS project : A component of French Climate Services

    NASA Astrophysics Data System (ADS)

    Lémond, J.; Dandin, P.; Moisselin, J. M.; Franchistéguy, L.; Kerdoncuff, M.; Pagé, C.; Vautard, R.; Déqué, M.; Planton, S.

    2010-09-01

    DRIAS (Providing access to French Regionalized climate scenarios for the Impact and the Adaptation of our Societies and environment) is a 2 years project, funded by the GICC (Management and Impacts of Climate Change) programme of the French Ministery of Ecology and Sustainable Development. Its aim is to provide regionalized climate simulations, data and products performed by French climate modeling, as well as to support users of these informations. In addition to numerical data, the project aims to make available probabilistic products, allowing the user to apprehend and take into account in studies the uncertainty inherent in modeling. From a technical perspective, the challenge will be to provide standardized informations between different producers. The combined accompaniment should be under different forms (metadata, hotline, training, forum), which will allow optimal use of products supplied. DRIAS gathers different partners and expertises. Its composed by representatives of French laboratories in which regionalized numerical simulations are produced : IPSL, CERFACS, and CNRM. The project is coordonned by the Climatology Departement of Météo-France which will provide expertise in the production and tools of availability of climatological data, acquired through the development of an existing data service access called Climathèque (http://climatheque.meteo.fr). In addition, a multidisciplinary committee of users representing different sectors concerned by climate change and different kind of structures (public, parapublic, private, association) accompanies the project. Its role is to express needs, validate the choices made, do tests... and thus facilitate communication between producers and users. Thus, the DRIAS project participates in the development effort of French Climate Services. The aim of this work is to present and introduce these key aspects.

  20. RELATION OF ENVIRONMENTAL CHARACTERISTICS TO FISH ASSEMBLAGES IN THE UPPER FRENCH BROAD RIVER BASIN, NORTH CAROLINA

    EPA Science Inventory

    Fish assemblages at 16 sites in the upper French Broad River basin, North Carolina were related to environmental variables using detrended correspondence analysis (DCA) and linear regression. This study was conducted at the landscape scale because regional variables are controlle...