Science.gov

Sample records for fuel depot shaw

  1. 76 FR 22735 - Shaw AREVA MOX Services, Mixed Oxide Fuel Fabrication Facility; License Amendment Request, Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... COMMISSION Shaw AREVA MOX Services, Mixed Oxide Fuel Fabrication Facility; License Amendment Request, Notice... PDR reference staff at 1-800-397-4209, 301-415-4737, or by e-mail to pdr.resource@nrc.gov . The.... Introduction The NRC has received, by letter dated February 8, 2011, an amendment request from Shaw AREVA...

  2. Architecture Study for a Fuel Depot Supplied from Lunar Resources

    NASA Technical Reports Server (NTRS)

    Perrin, Thomas M.

    2016-01-01

    Heretofore, discussions of space fuel depots assumed the depots would be supplied from Earth. However, the confirmation of deposits of water ice at the lunar poles in 2009 suggests the possibility of supplying a space depot with liquid hydrogen/liquid oxygen produced from lunar ice. This architecture study sought to determine the optimum architecture for a fuel depot supplied from lunar resources. Four factors - the location of propellant processing (on the Moon or on the depot), the location of the depot (on the Moon, or at L1, GEO, or LEO), the location of propellant transfer (L1, GEO, or LEO), and the method of propellant transfer (bulk fuel or canister exchange) were combined to identify 18 potential architectures. Two design reference missions (DRMs) - a satellite servicing mission and a cargo mission to Mars - were used to create demand for propellants, while a third DRM - a propellant delivery mission - was used to examine supply issues. The architectures were depicted graphically in a network diagram with individual segments representing the movement of propellant from the Moon to the depot, and from the depot to the customer.

  3. Architecture Study for a Fuel Depot Supplied from Lunar Resources

    NASA Technical Reports Server (NTRS)

    Perrin, Thomas M.

    2016-01-01

    Heretofore, discussions of space fuel depots assumed the depots would be supplied from Earth. However, the confirmation of deposits of water ice at the lunar poles in 2009 suggests the possibility of supplying a space depot with liquid hydrogen/liquid oxygen produced from lunar ice. This architecture study sought to determine the optimum architecture for a fuel depot supplied from lunar resources. Four factors - the location of propellant processing (on the Moon or on the depot), the location of the depot (on the Moon or in cislunar space), and if in cislunar space, where (LEO, GEO, or Earth-Moon L1), and the method of propellant transfer (bulk fuel or canister exchange) were combined to identify 18 potential architectures. Two design reference missions (DRMs) - a satellite servicing mission and a cargo mission to Mars - were used to create demand for propellants, while a third DRM - a propellant delivery mission - was used to examine supply issues. The architectures were depicted graphically in a network diagram with individual segments representing the movement of propellant from the Moon to the depot, and from the depot to the customer

  4. Thermal Examination of an Orbiting Cryogenic Fuel Depot

    NASA Technical Reports Server (NTRS)

    Hull, Patrick V.; Canfield, Steven L.; Carrington, Connie; Fikes, John

    2002-01-01

    For many years NASA has been interested in the storage and transfer of cryogenic fuels in space. Lunar, L2 and other chemical propulsive space vehicle missions now have staged refueling needs that a fuel depot would satisfy. The depot considered is located in lower earth orbit. Many considerations must go into designing and building such a station. Multi-layer insulation systems, thermal shielding and low conductive structural supports are the principal means of protecting the system from excessive heat loss due to boiloff. This study focuses on the thermal losses associated with storing LH2 in a passively cooled fuel depot in a lower earth equatorial orbit. The corresponding examination looks at several configurations of the fuel depot. An analytical model has been developed to determine the thermal advantages and disadvantages of three different fuel depot configurations. Each of the systems consists of three Boeing rocket bodies arranged in various configurations. The first two configurations are gravity gradient stabilized while the third one is a spin-stabilized concept. Each concept was chosen for self-righting capabilities as well as the fuel settling capabilities, however the purpose of this paper is to prove which of the three concepts is the most efficient passively cooled system. The specific areas to be discussed are the heating time from the fusion temperature to the vaporization temperature and the amount of boiloff for a specific number of orbits. Each of the previous points is compared using various sun exposed surface areas of the tanks.

  5. Architecture Study for a Fuel Depot Supplied from Lunar Assets

    NASA Technical Reports Server (NTRS)

    Perrin, Thomas M.; Casler, James G.

    2016-01-01

    This architecture study sought to determine the optimum architecture for a fuel depot supplied from lunar assets. Four factors - the location of propellant processing (on the Moon or on the depot), the depot location (on the Moon, L1, GEO, or LEO), the propellant transfer location (L1, GEO, or LEO), and the propellant transfer method (bulk fuel or canister exchange) were combined to identify 18 candidate architectures. Two design reference missions (DRMs) - a commercial satellite servicing mission and a Government cargo mission to Mars - created demand for propellants, while a propellant delivery DRM examined supply issues. The study concluded Earth-Moon L1 is the best location for an orbiting depot. For all architectures, propellant boiloff was less than anticipated, and was far overshadowed by delta-v requirements and resulting fuel consumption. Bulk transfer is the most flexible for both the supplier and customer. However, since canister exchange bypasses the transfer of bulk cryogens and necessary chilldown losses, canister exchange shows promise and merits further investigation. Overall, this work indicates propellant consumption and loss is an essential factor in assessing fuel depot architectures.

  6. Technology requirements for an orbiting fuel depot: A necessary element of a space infrastructure

    NASA Technical Reports Server (NTRS)

    Stubbs, R. M.; Corban, R. R.; Willoughby, A. J.

    1988-01-01

    Advanced planning within NASA has identified several bold space exploration initiatives. The successful implementation of these missions will require a supporting space infrastructure which would include a fuel depot, an orbiting facility to store, transfer and process large quantities of cryogenic fluids. In order to adequately plan the technology development programs required to enable the construction and operation of a fuel depot, a multidisciplinary workshop was convened to assess critical technologies and their state of maturity. Since technology requirements depend strongly on the depot design assumptions, several depot concepts are presented with their effect on criticality ratings. Over 70 depot-related technology areas are addressed.

  7. Technology requirements for an orbiting fuel depot - A necessary element of a space infrastructure

    NASA Technical Reports Server (NTRS)

    Stubbs, R. M.; Corban, R. R.; Willoughby, A. J.

    1988-01-01

    Advanced planning within NASA has identified several bold space exploration initiatives. The successful implementation of these missions will require a supporting space infrastructure which would include a fuel depot, an orbiting facility to store, transfer and process large quantities of cryogenic fluids. In order to adequately plan the technology development programs required to enable the construction and operation of a fuel depot, a multidisciplinary workshop was convened to assess critical technologies and their state of maturity. Since technology requirements depend strongly on the depot design assumptions, several depot concepts are presented with their effect of criticality ratings. Over 70 depot-related technology areas are addressed.

  8. 33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Puget Sound, Manchester Fuel... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a) The area. The waters of Puget Sound surrounding the Manchester Fuel Depot Point A, a point along...

  9. 33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Puget Sound, Manchester Fuel... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a) The area. The waters of Puget Sound surrounding the Manchester Fuel Depot Point A, a point along...

  10. 33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Puget Sound, Manchester Fuel... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a) The area. The waters of Puget Sound surrounding the Manchester Fuel Depot Point A, a point along...

  11. 77 FR 70193 - Shaw Areva MOX Services (Mixed Oxide Fuel Fabrication Facility); Notice of Atomic Safety and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Shaw Areva MOX Services (Mixed Oxide Fuel Fabrication Facility); Notice of Atomic Safety and Licensing Board Reconstitution Pursuant to 10 CFR 2.313(c) and 2.321(b), the Atomic Safety and...

  12. 78 FR 9431 - Shaw AREVA MOX Services, LLC (Mixed Oxide Fuel Fabrication Facility); Order Approving Indirect...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... COMMISSION [NRC-2011-0081; Docket No. 70-3098; Construction Authorization No. CAMOX-001] Shaw AREVA MOX... Construction Authorization I Shaw AREVA MOX Services, LLC (MOX Services) holds Construction ] Authorization (CA... served as the mechanism under which the NRC staff has overseen the MFFF construction activities....

  13. Enhancement of polycyclic aromatic hydrocarbons in estuarine invertebrates by surface runoff at a decommissioned military fuel depot

    USGS Publications Warehouse

    Miles, A.K.; Roster, N.

    1999-01-01

    Accumulation of polycyclic aromatic hydrocarbons (PAHs) was determined in blue mussels (Mytilus spp.) and shore crabs (Hemigrapsus sp.) at a recently closed military fuel depot in central San Francisco Bay, California. In April 1996, during a period of above average precipitation, specimens were collected at the depot, near the depot, and at sites 10 and 20 km south of the depot. Four weeks after the rains ended, blue mussels were again collected at the depot, and at two additional sites in the central Bay region. In April, total PAHs in mussels from the depot were significantly higher only than that in mussels collected 20 km from the depot; however, seven specific, substituted PAHs were higher at the depot than at all other sites. In June, only two of the 38 PAHs common in mussels in April were detected at the depot; these concentrations were comparable to ambient concentrations in mussels at the Bay. It seemed that bioavailability of PAHs at the depot was enhanced by rainfall, probably due to the mobilization of PAHs via groundwater into the Bay. Concentrations in mussels from chronically contaminated sites were about five times higher than mussels collected from the depot. Low PAH concentrations were detected in shore crabs near the depot, and the highest levels were not associated with the depot. Observed PAH concentrations are discussed in relation to upper trophic organisms.

  14. Navy looks to bugs for cleanup task. [Bioremediation of Naval Fuel Depot

    SciTech Connect

    Not Available

    1993-05-03

    The US Navy is about to step into bioremediation in a big way, using the largest naval fuel depot in the continental US as a test bed for better ways to clean oil-soaked soils. Craney Island, a 900-acre peninsula near Portsmouth, Va., has been the Navy's main East Coast fueling depot since World War II. In the next few weeks, a 15-acre site on the island will be transformed into the largest bioremediation experiment on the East Coast, say officials with the Naval Facilities Engineering Command (NAVFAC), Atlantic Division, which is in charge of the cleanup for the Fleet and Industrial Supply Center at Norfolk, VA. The site is extremely contaminated with petroleum, oil and lubricants (POL), primarily ship bunker fuel, and it will be cleaned up under the Navy's Installation Restoration Program, says John Peters, a NAVFAC spokesman. Using naturally occurring bacteria, the contractor will churn and aerate the soil, add lime and fertilizers, bring the moisture level to 20% and allow the mix to [open quote]bake[close quote] for about four months.

  15. Factor of explosiveness of pulverized fuel as a basis for classification of natural solid fuels with respect to their storageability in open coal depots

    SciTech Connect

    E.N. Tolchinskii; A.Yu. Lavrent'ev

    2003-01-15

    Existing methods for estimating the storageability of fuel in open coal depots are analyzed. It is inferred that the capacity of coals for oxidation and spontaneous combustion cannot be unambiguously associated with the name of the coal basin, deposit, or grade. Methods for calculating a generalized parameter reflecting a fuel group are suggested. It is shown that the explosiveness factor Kf of solid fuels calculated from the data on technical and elemental compositions can be used as a generalized characteristic for classifying fuels according to their resistance to oxidation and spontaneous combustion.

  16. Shaw on Hamlet

    ERIC Educational Resources Information Center

    Dukore, Bernard F.

    1971-01-01

    Shaw's preoccupation with Hamlet resonates in his creative writing. Article documents this statement not only by examining his novels and plays but by searching through prefaces, postscripts, reviews, letters, speeches, etc. that span Shaw's lifetime. (Author/RB)

  17. Shaw on Hamlet

    ERIC Educational Resources Information Center

    Dukore, Bernard F.

    1971-01-01

    Shaw's preoccupation with Hamlet resonates in his creative writing. Article documents this statement not only by examining his novels and plays but by searching through prefaces, postscripts, reviews, letters, speeches, etc. that span Shaw's lifetime. (Author/RB)

  18. Oil fuel delivery optimization for multi product and multi depot: the case of petrol station replenishment problem (PSRP)

    NASA Astrophysics Data System (ADS)

    Surjandari, Isti; Rachman, Amar; Dianawati, Fauzia; Wibowo, R. Pramono

    2011-10-01

    With the Oil and Gas Law No. 22 of 2001, national and foreign private enterprises can invest in all sectors of Oil and Gas in Indonesia. In anticipation of this free competition, Pertamina, as a state-owned enterprises, which previously had monopolized the oil and gas business activities in Indonesia, should be able to improve services as well as the efficiency in order to compete in the free market, especially in terms of cost efficiency of fuel distribution to gas station (SPBU). To optimize the distribution activity, it is necessary to design a scheduling system and its fuel delivery routes daily to every SPBU. The determination of routes and scheduling delivery of fuel to the SPBU can be modeled as a Petrol Station Replenishment Problem (PSRP) with the multi-depot, multi-product, time windows and split deliveries, which in this study will be completed by the Tabu Search algorithm (TS). This study was conducted in the area of Bandung, the capital of West Java province, which is a big city and the neighboring city of Jakarta, the capital city of Indonesia. By using the fuel delivery data for one day, the results showed a decrease of 16.38% of the distance of the route compared to the current conditions, which impacted on the reduction of distribution costs and decrease the number of total trips by 5.22% and 3.83%.

  19. Depot Maintenance Modernization

    DTIC Science & Technology

    1988-02-01

    Depot Activity Pueblo, Colorado Savanna Depot Activity Savanna, Illinois Umatilla Depot Activity Hermiston, Oregon Navajo Depot Activity Bellemont...under- taking of the project. This includes services for accounting, personnel, legal, local procurement, medicine , storage, issue of supplies, police

  20. Flamelet Formation In Hele-Shaw Flow

    NASA Technical Reports Server (NTRS)

    Wichman, I. S.; Olson, S. L.

    2003-01-01

    A Hele-Shaw flow apparatus constructed at Michigan State University (MSU) produces conditions that reduce influences of buoyancy-driven flows. In addition, in the MSU Hele-Shaw apparatus it is possible to adjust the heat losses from the fuel sample (0.001 in. thick cellulose) and the flow speed of the approaching oxidizer flow (air) so that the "flamelet regime of flame spread" is entered. In this regime various features of the flame-to-smolder (and vice versa) transition can be studied. For the relatively wide (approx. 17.5 cm) and long (approx. 20 cm) samples used, approximately ten flamelets existed at all times. The flamelet behavior was studied mechanistically and statistically. A heat transfer analysis of the dominant heat transfer mechanisms was conducted. Results indicate that radiation and conduction processes are important, and that a simple 1-D model using the Broido-Shafizadeh model for cellulose decomposition chemistry can describe aspects of the flamelet spread process. Introduction

  1. Josh Billings (Henry Wheeler Shaw).

    ERIC Educational Resources Information Center

    Kesterson, David B.

    Designed for use by the general reader, the college student, and the teacher, this book analyzes the life and literary career of Josh Billings (Henry Wheeler Shaw), emphasizing his literary ventures and artistic talents. The analysis reveals Billings' talents as a subtle humorist, homespun philosopher, and artist of the essay. Chapters include…

  2. Simulation of over-winter soil water and soil temperature with SHAW and RZ-SHAW

    USDA-ARS?s Scientific Manuscript database

    Correct simulation of over-winter condition is important for the growth of winter crops and for initial growth of spring crops. RZ-SHAW (RZWQM-SHAW) is a newly developed model by coupling the Root Zone Water Quality Model (RZWQM) and the Simultaneous Heat and Water (SHAW) model. The objective of thi...

  3. 33 CFR 117.223 - Shaw Cove.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Shaw Cove. 117.223 Section 117.223 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.223 Shaw Cove. The draw of the Amtrak bridge...

  4. 33 CFR 117.223 - Shaw Cove.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Shaw Cove. 117.223 Section 117.223 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.223 Shaw Cove. The draw of the Amtrak bridge...

  5. 33 CFR 117.223 - Shaw Cove.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Shaw Cove. 117.223 Section 117.223 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.223 Shaw Cove. The draw of the Amtrak bridge...

  6. 33 CFR 117.223 - Shaw Cove.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Shaw Cove. 117.223 Section 117.223 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.223 Shaw Cove. The draw of the Amtrak bridge...

  7. Shaw's Comedy, Language Arts: 5113.90.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This guide provides the teacher with strategies to aid students in examining five representative plays by Bernard Shaw and in comparing his comedy with the comic art of Oscar Wilde, Richard Sheridan, Ben Jonson, and William Shakespeare. Performance objectives include isolating elements which pertain to the life and times of Shaw, delineating…

  8. Fishman Receives the Shaw Prize for Astronomy

    NASA Image and Video Library

    In the video, Dr. Jerry Fishman discusses his career as a scientist, his lifelong interest in science and his recognition as the 2011 Shaw Prize Recipient for Astronomy. Fishman is being recognized...

  9. Risperidone (depot) for schizophrenia.

    PubMed

    Sampson, Stephanie; Hosalli, Prakash; Furtado, Vivek A; Davis, John M

    2016-04-14

    Risperidone is the first new generation antipsychotic drug made available in a long-acting injection formulation. To examine the effects of depot risperidone for treatment of schizophrenia or related psychoses in comparison with placebo, no treatment or other antipsychotic medication.To critically appraise and summarise current evidence on the resource use, cost and cost-effectiveness of risperidone (depot) for schizophrenia. We searched the Cochrane Schizophrenia Group's Register (December 2002, 2012, and October 28, 2015). We also checked the references of all included studies, and contacted industry and authors of included studies. Randomised clinical trials comparing depot risperidone with other treatments for people with schizophrenia and/or schizophrenia-like psychoses. Two review authors independently selected trials, assessed trial quality and extracted data. For dichotomous data, we calculated the risk ratio (RR), with 95% confidence interval (CI). For continuous data, we calculated mean differences (MD). We assessed risk of bias for included studies and created 'Summary of findings' tables using GRADE. Twelve studies, with a total of 5723 participants were randomised to the following comparison treatments: Risperidone depot versus placebo Outcomes of relapse and improvement in mental state were neither measured or reported. In terms of other primary outcomes, more people receiving placebo left the study early by 12 weeks (1 RCT, n=400, RR 0.74 95% CI 0.63 to 0.88, very low quality evidence), experienced severe adverse events in short term (1 RCT, n=400, RR 0.59 95% CI 0.38 to 0.93, very low quality evidence). There was however, no difference in levels of weight gain between groups (1 RCT, n=400, RR 2.11 95% CI 0.48 to 9.18, very low quality evidence). Risperidone depot versus general oral antipsychotics The outcome of improvement in mental state was not presented due to high levels of attrition, nor were levels of severe adverse events explicitly reported

  10. STS-28 Columbia, OV-102, Commander Shaw on middeck

    NASA Technical Reports Server (NTRS)

    1989-01-01

    At open middeck stowage locker, Commander Brewster H. Shaw pauses to have his picture taken. Behind Shaw on port side wall are solid sorbent air sampler, a plastic storage bag filled with wheat crackers, and various food and beverage containers.

  11. Official portrait of astronaut Brewster H. Shaw, Jr

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Official portrait of Brewster H. Shaw, Jr, United States Air Force (USAF) Colonel, member of Astronaut Class 8 (1978), and space shuttle commander. Shaw wears blue pressure suit with space shuttle model displayed on table on his left.

  12. STS-28 Columbia, OV-102, Commander Shaw on middeck

    NASA Technical Reports Server (NTRS)

    1989-01-01

    At open middeck stowage locker, Commander Brewster H. Shaw pauses to have his picture taken. Behind Shaw on port side wall are solid sorbent air sampler, a plastic storage bag filled with wheat crackers, and various food and beverage containers.

  13. Telerobotics for depot modernization

    NASA Technical Reports Server (NTRS)

    Leahy, M. B., Jr.; Petroski, S. B.

    1994-01-01

    Development and application of telerobotics technology for the enhancement of the quality of the Air Logistic Centers (ALC) repair and remanufacturing processes is described. Telerobotics provides the means for bridging the gap between manual operation and full automation. The Robotics and Automation Center for Excellence (RACE) initiated the Unified Telerobotics Architecture Project (UTAP) to support the development and application of telerobotics for depot operation.

  14. Depot fluphenazine for schizophrenia.

    PubMed

    Adams, C E; Eisenbruch, M

    2000-01-01

    In the years after the discovery of oral antipsychotic medications, it became clear that there was a link between stopping medication and relapse of psychotic symptoms. A series of long-acting preparations was developed. These depot preparations, are frequently used for those who find taking oral medication on a regular basis difficult or unacceptable. However, it has been a consistent concern that any reduction in relapse rate afforded by the depot preparations may be offset by an increase in undesirable side effects. There is one oral preparation and two depot forms (enanthate (Moditen) and decanoate (Modecate)). The decanoate form is more frequently used but both versions were reviewed in this work. To compare depot fluphenazine medication to oral fluphenazine for treatment of schizophrenia. Electronic searches of Biological Abstracts, CSG's Register, EMBASE, LILACS, MEDLINE, PsycLIT, SCISEARCH, hand searching the references of all identified studies and contacting the manufacturers of the compounds. All randomised clinical trials that compared fluphenazine enanthate or fluphenazine decanoate to oral fluphenazine for people with schizophrenia or other psychoses were included. One reviewer (CEA) inspected study citations and then the second reviewer (ME) independently inspected 20% of citations to ensure reliability. Full reports of the studies of agreed relevance were obtained and data extracted in the same manner by the authors. Trials were allocated to three quality categories, as described in the Cochrane Collaboration Handbook. Data were analysed on an intention-to-treat basis, and, where possible, parametric continuous data were presented. Tests for heterogeneity were undertaken. Data were very limited. There was no difference between fluphenazine hydrochloride and its depot form for outcomes such as global impression of functioning, relapse/re-hospitalisation, poor initial response to treatment, leaving the study early, depressed mood / suicide and side

  15. Young and Shaw in Shuttle Training Aircraft

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Astronaut Brewster Shaw, Jr., pilot for STS-9, gets in some practice time over Florida at the controls of the Shuttle Training aircraft (STA). He is turned away from the camera but his name can be seen written on his helmet (41434); Astronaut John W. Young, STS-9 commander, gets in some practice in approach and landing over Florida at the controls of the STA. He is turned away from the camera (41435-6).

  16. Whole tree transportation system for timber processing depots

    Treesearch

    John Lancaster; Tom Gallagher; Tim McDonald; Dana Mitchell

    2017-01-01

    The growing demand for alternative energy has led those interested in producing sustainable energy from renewable biomass such as timber to devise new concepts to satisfy those demands. The concept of timber processing depots, where whole stem trees will be delivered for future processing into wood products and high quality energy fuel, has led to the reevaluation of...

  17. Whole tree transportation system for timber processing depots

    Treesearch

    John Lancaster; Tom Gallagher; Tim  McDonald; Dana Mitchell

    2016-01-01

    The growing demand for alternative energy has led those who are interested in producing sustainable energy from renewable timber to devise new concepts to satisfy those demands. The concept of timber processing depots, where whole stem trees will be delivered for future processing into wood products and high quality energy fuel, has led to the re-evaluation of our...

  18. Function Point Analysis Depot

    NASA Technical Reports Server (NTRS)

    Muniz, R.; Martinez, El; Szafran, J.; Dalton, A.

    2011-01-01

    The Function Point Analysis (FPA) Depot is a web application originally designed by one of the NE-C3 branch's engineers, Jamie Szafran, and created specifically for the Software Development team of the Launch Control Systems (LCS) project. The application consists of evaluating the work of each developer to be able to get a real estimate of the hours that is going to be assigned to a specific task of development. The Architect Team had made design change requests for the depot to change the schema of the application's information; that information, changed in the database, needed to be changed in the graphical user interface (GUI) (written in Ruby on Rails (RoR and the web service/server side in Java to match the database changes. These changes were made by two interns from NE-C, Ricardo Muniz from NE-C3, who made all the schema changes for the GUI in RoR and Edwin Martinez, from NE-C2, who made all the changes in the Java side.

  19. Simulating the surface energy balance in a soybean canopy with SHAW and RZ-SHAW models

    USDA-ARS?s Scientific Manuscript database

    Correct simulation of surface energy balance in a crop canopy is critical for better understanding of soil water balance, canopy and soil temperature, plant water stress, and plant growth. One existing effort is to incorporate the surface energy balance in the Simultaneous Heat And Water (SHAW) into...

  20. Herbert R. Shaw (1930-2002)

    NASA Astrophysics Data System (ADS)

    Glen, William

    Herbert Richard Shaw, a highly distinguished Scientist Emeritus with the U.S. Geological Survey (USGS), succumbed at home on 26 August 2002, at the age of 71, to long-term complications of congestive heart failure. He had been an AGU member (VGP) since 1968. Herb was admired for his unstinting generosity of intellect, spirit, and resources, and the ease and frequency with which he dispensed grace, where most others merely practice civility. He shared his own ideas freely and, with an infectious enthusiasm, encouraged the efforts of colleagues and students.

  1. Rediscovering Ruth Faison Shaw and Her Finger-Painting Method

    ERIC Educational Resources Information Center

    Mayer, Veronica

    2005-01-01

    Ruth Faison Shaw was an art educator who developed a nontraditional educational perspective of teaching and a different vision about children's art. As such, she is considered by some to be the initiator of finger-painting in America (The History of Art Education Timeline 1930-1939, 2002.) Shaw developed the technique of finger-painting and a…

  2. Wulf Cattle Depot NPDES Permit

    EPA Pesticide Factsheets

    Under NPDES permit SD-0034606, the Wulf Cattle Depot is authorized to discharge and must operate their facility in accordance with effluent limitations, monitoring requirements, and other provisions set forth herein.

  3. FPA Depot - Web Application

    NASA Technical Reports Server (NTRS)

    Avila, Edwin M. Martinez; Muniz, Ricardo; Szafran, Jamie; Dalton, Adam

    2011-01-01

    Lines of code (LOC) analysis is one of the methods used to measure programmer productivity and estimate schedules of programming projects. The Launch Control System (LCS) had previously used this method to estimate the amount of work and to plan development efforts. The disadvantage of using LOC as a measure of effort is that one can only measure 30% to 35% of the total effort of software projects involves coding [8]. In the application, instead of using the LOC we are using function point for a better estimation of hours in each software to develop. Because of these disadvantages, Jamie Szafran of the System Software Branch of Control And Data Systems (NE-C3) at Kennedy Space Canter developed a web application called Function Point Analysis (FPA) Depot. The objective of this web application is that the LCS software architecture team can use the data to more accurately estimate the effort required to implement customer requirements. This paper describes the evolution of the domain model used for function point analysis as project managers continually strive to generate more accurate estimates.

  4. John Shaw Billings as a Bibliographer

    PubMed Central

    Marson, Joyce

    1969-01-01

    The influences that a man's childhood have on his life are, it is well known, great. Life is essentially a part of the things that happen to the individual and it is the manner in which one relates oneself to these things that determines what one is. With these facts in mind this study of John Shaw Billings as a bibliographer has been approached. His early life has been reviewed as an influence on his later achievements. Stress has been placed on those events which led to his bibliographic activities. Dr. Billings was prolific in many fields. Others have given detailed analyses of his writings (1, 2). The present study will consider only his bibliographic works. The description of these follows the brief outline of his childhood and youth. PMID:4898628

  5. 32. SHAW BOX 5 TON CRANE, SANTA ANA RIVER NO. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. SHAW BOX 5 TON CRANE, SANTA ANA RIVER NO. 3, JAN. 24, 1977. SCE drawing no. 455678-0. - Santa Ana River Hydroelectric System, SAR-3 Powerhouse, San Bernardino National Forest, Redlands, San Bernardino County, CA

  6. 110. Shaws Cove Bridge. New London, New London Co., CT. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    110. Shaws Cove Bridge. New London, New London Co., CT. Sec. 4209, MP 122.65. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  7. 111. Shaws Cove Bridge. New London, New London Co., CT. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    111. Shaws Cove Bridge. New London, New London Co., CT. Sec. 4209, MP 122.65. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  8. Shaw Air Force Base Capital Improvement Program Environmental Assessment

    DTIC Science & Technology

    2010-05-01

    or reduce sediment and non -storm water discharges. For projects disturbing more than 1 acre, a South Carolina Pollutant Discharge Elimination System...of Contents Shaw AFB Capital Improvement Program Environmental Assessment vi THIS PAGE INTENTIONALLY LEFT BLANK. Shaw AFB Capital Improvement...SWPPP) to eliminate or reduce sediment and non -storm water discharges. For projects disturbing more than 1 acre, a South Carolina Pollutant

  9. Shaw Prize Goes to Reinhard Genzel

    NASA Astrophysics Data System (ADS)

    2008-06-01

    The Shaw Prize in Astronomy for 2008 is awarded to Professor Reinhard Genzel, Director of the Max Planck Institute for Extraterrestrial Physics (MPE), in recognition of his outstanding contribution in demonstrating that the Milky Way contains a supermassive black hole at its centre, a result largely obtained with the help of ESO's telescopes. Black Hole ESO PR Photo 18/08 Motion of a Star The Shaw Prize is awarded annually by the Shaw Prize Foundation in Hong Kong in the Life Sciences, Mathematical Sciences and Astronomy, each of the three prizes bearing a monetary award of one million US dollars. "I warmly congratulate Professor Genzel for this well-deserved award which highlights some of the best science produced with ESO's telescopes," says Tim de Zeeuw, ESO's Director General. "Professor Genzel and his team have made a dedicated, long-term effort, using our telescopes and co-developing instruments, to study the Centre of our Galaxy, and as such, he has allowed us to enter an era of observational black hole physics." In 1969, Donald Lynden-Bell and Martin Rees suggested that the Milky Way might contain a supermassive black hole at its centre. But evidence for such an object was lacking at the time because the centre of the Milky Way is obscured by interstellar dust, and was detected only as a relatively faint radio source. Reinhard Genzel and his collaborators obtained compelling evidence for this black hole by developing state-of-the-art astronomical instruments to be used on ESO's telescopes and carrying out a persistent programme of observing the Galactic Centre and its surrounding stars for many years, which ultimately led to the discovery of a black hole with a mass of about three million times that of the Sun. Genzel's group has in particular followed since 1992, the motion of several stars, around the Galactic Centre. These observations were first done with the MPE-built near-infrared speckle imaging camera SHARP on ESO's New Technology Telescope at La

  10. Simple, Robust Cryogenic Propellant Depot for Near Term Applications

    NASA Technical Reports Server (NTRS)

    McLean, Christopher; Pitchford, Brian; Mustafi, Shuvo; Wollen, Mark; Walls, Laurie; Schmidt, Jeff

    2011-01-01

    The ability to refuel cryogenic propulsion stages on-orbit provides an innovative paradigm shift for space transportation supporting National Aeronautics and Space Administration s (NASA) Exploration program as well as deep space robotic, national security and commercial missions. Refueling enables large beyond low Earth orbit (LEO) missions without requiring super heavy lift vehicles that must continuously grow to support increasing mission demands as America s exploration transitions from early Lagrange point missions to near Earth objects (NEO), the lunar surface and eventually Mars. Earth-to-orbit launch can be optimized to provide competitive, cost-effective solutions that allow sustained exploration. This paper describes an experimental platform developed to demonstrate the major technologies required for fuel depot technology. This test bed is capable of transferring residual liquid hydrogen (LH2) or liquid oxygen (LO2) from a Centaur upper stage, and storage in a secondary tank for up to one year on-orbit. A dedicated, flight heritage spacecraft bus is attached to an Evolved Expendable Launch Vehicle (EELV) Secondary Payload Adapter (ESPA) ring supporting experiments and data collection. This platform can be deployed as early as Q1 2013. The propellant depot design described in this paper can be deployed affordably this decade supporting missions to Earth-Moon Lagrange points and lunar fly by. The same depot concept can be scaled up to support more demanding missions and launch capabilities. The enabling depot design features, technologies and concept of operations are described.

  11. Electrokinetic Fingering In Hele-Shaw Cells

    NASA Astrophysics Data System (ADS)

    Mirzadeh, Mohammad; Bazant, Martin

    2016-11-01

    Large scale flow problems in porous media, such as those encountered in underground oil reservoirs, are typically described by the Darcy's law. However, it is well known that many underground rock formations contain surface groups and minerals that dissociate in the presence of water. Convection of these charges by the pressure driven flow can then set up streaming current and streaming potential that affects the flow. Furthermore, electric fields that are often used to enhance oil recovery, e.g. by reducing the oil's viscosity through electro-thermal heating, drive electro-osmotic flows that could set up very large pressure in small pores. The full description of fluid flow thus requires a solution to the fully coupled electrokinetic problem. In their seminal work, Saffman and Taylor showed that the moving interface between two immiscible fluids in a porous medium becomes unstable if pushed by the low-viscosity fluid. Here we report on the role of electrokinetic phenomena on stability of these viscous fronts in Hele-Shaw cells by using analytic as well as numerical approaches. Interestingly, we find that the instability could be suppressed if the right physical conditions are met or otherwise enhanced, leading to greater mixing of two fluids.

  12. Depot Maintenance: Executed Workload and Maintenance Operations at DOD Depots

    DTIC Science & Technology

    2017-02-03

    level maintenance on a wide range of vehicles and other military assets , including helicopters, combat vehicles, ships, aircraft, engines, and software... capital investments, process improvements, and public-private partnerships in enclosure I. To perform our work, we reviewed 10 U.S.C. § 2464 and DOD... capital investments.7 This non-generalizable sample was selected to ensure a mix of military services (at least one per type of site—Army depot, Navy

  13. The Shaw chondrite. I - The case of the missing metal

    NASA Technical Reports Server (NTRS)

    Rambaldi, E. R.; Larimer, J. W.

    1976-01-01

    The mineralogy as well as the elemental and isotopic composition of the Shaw meteorite indicate that it is a highly metamorphosed L-group chondrite which has lost a portion of its metal and sulfide. The metal which remains has an unusual composition relative to that in other L-group chondrites. It is enriched in Ga, Ge, Ir, Mo, Os, Pt, Re, and Ru but depleted in As, Au, Cu, and Sb. A comparison of the relative enrichments and depletions in Shaw with those observed in San Cristobal, the extreme end-member of group IAB iron meteorites, shows that the metal phases in these two meteorites have complementary compositions. This implies that the metal in Shaw represents the residual solid of a partial melting process while the missing metal, which drained away, may have gone to form an iron meteorite, like San Cristobal.

  14. Fingers in a Hele-Shaw Cell with Surface Tension.

    DTIC Science & Technology

    1983-05-01

    A138 548 FINGERS IN A HELE-SHAid CELL WITH SURFACE TENSION (U) i/i WISCONSIN UN! V-*MADISON MATHEMATICS RESEARCH CENTER J YANDEN-BROECI( MAY 83 MRC...NATIONAL BUREAU OF STANDARDS-1963-A A-4" MRC Technical Simimary Report #2518 i. FINGERS IN A HELE-SHAW CELLQ WITH SURFACE TENSION V=4 Jean-Marc...H CENTER "’ FINGERS IN A HXLZ-SHAW CELL WITH SURFACE TENSION Jean-Marc Vanden-Broeck Technical Summary Report #2518 May 1983 ABSTRACT McLean and

  15. 9. Interior, room in southeast corner of depot looking southeast ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Interior, room in southeast corner of depot looking southeast - Missouri Pacific Railway Depot, Natches Street (State Highway 15) & Pine Street intersection, northeast corner, Wisner, Franklin Parish, LA

  16. 10. Interior, room in southwest corner of depot looking northeast ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Interior, room in southwest corner of depot looking northeast - Missouri Pacific Railway Depot, Natches Street (State Highway 15) & Pine Street intersection, northeast corner, Wisner, Franklin Parish, LA

  17. Space Transportation Infrastructure Supported By Propellant Depots

    NASA Technical Reports Server (NTRS)

    Smitherman, David; Woodcock, Gordon

    2011-01-01

    A space transportation infrastructure is described that utilizes propellant depots to support all foreseeable missions in the Earth-Moon vicinity and deep space out to Mars. The infrastructure utilizes current expendable launch vehicles such as the Delta IV Heavy, Atlas V, and Falcon 9, for all crew, cargo, and propellant launches to orbit. Propellant launches are made to a Low-Earth-Orbit (LEO) Depot and an Earth-Moon Lagrange Point 1 (L1) Depot to support new reusable in-space transportation vehicles. The LEO Depot supports missions to Geosynchronous Earth Orbit (GEO) for satellite servicing, and to L1 for L1 Depot missions. The L1 Depot supports Lunar, Earth-Sun L2 (ESL2), Asteroid, and Mars missions. A Mars Orbital Depot is also described to support ongoing Mars missions. New concepts for vehicle designs are presented that can be launched on current 5-meter diameter expendable launch vehicles. These new reusable vehicle concepts include a LEO Depot, L1 Depot, and Mars Orbital Depot based on International Space Station (ISS) heritage hardware. The high-energy depots at L1 and Mars orbit are compatible with, but do not require, electric propulsion tug use for propellant and/or cargo delivery. New reusable in-space crew transportation vehicles include a Crew Transfer Vehicle (CTV) for crew transportation between the LEO Depot and the L1 Depot, a new reusable Lunar Lander for crew transportation between the L1 Depot and the lunar surface, and a Deep Space Habitat (DSH) to support crew missions from the L1 Depot to ESL2, Asteroid, and Mars destinations. A 6 meter diameter Mars lander concept is presented that can be launched without a fairing based on the Delta IV heavy Payload Planners Guide, which indicates feasibility of a 6.5 meter fairing. This lander would evolve to re-usable operations when propellant production is established on Mars. Figure 1 provides a summary of the possible missions this infrastructure can support. Summary mission profiles are presented

  18. George Bernard Shaw's "Androcles and the Lion": A Postmodernist Study

    ERIC Educational Resources Information Center

    Hooti, Noorbakhsh; Jeihouni, Mojtaba

    2012-01-01

    This study makes an attempt to analyze the manifold aspects of Shaw's "Androcles and the Lion" on a postmodernist standpoint, meanwhile, demonstrates the dominion of modernism, which is portrayed through the vehicle of comedy with a bitter ironic language through the play. Regardless of the historical period in which the play occurs, the…

  19. The Music Criticism and Aesthetics of George Bernard Shaw

    ERIC Educational Resources Information Center

    Gates, Eugene

    2001-01-01

    Most people know George Bernard Shaw as a dramatist and social reformer, but they are often surprised to discover that he was also the most brilliant British music critic to emerge in the late-nineteenth century. His vision of the ideal critic was not a passive reporter of musical events, but rather a vital and initiating force within the music…

  20. STS-28 Columbia, OV-102, Commander Shaw on middeck

    NASA Image and Video Library

    1989-08-13

    STS028-11-017 (August 1989) --- Astronaut Brewster H. Shaw Jr., mission commander, is captured with a 35mm camera on the middeck of the space shuttle Columbia during the STS-28 flight. Nearby are a couple of beverage containers and a packet of wheat crackers.

  1. Network technology for depot modernization

    SciTech Connect

    Hostick, C.J.

    1990-12-01

    This report was prepared by the Pacific Northwest Laboratory to summarize existing and emerging information system technology and standards applicable to Depot System Command (DESCOM) modernization efforts. The intent of this summarization is to provide the Revitalization of Army Depots for the Year 2000 (READY 2000) team a clear understanding of the enabling information system technologies required to support effective modernization activities. Much of the information contained in this report was acquired during the last year in support of the US Army Armament, Munitions, and Chemical Command (AMCCOM) Facility Integrated Manufacturing Management System (FIMMS) project at PNL, which is targeting the modernization of plant-wide information systems at Army Ammunition Plants. The objective of information system modernization is to improve the effectiveness of an organization in performing its mission. Information system modernization strives to meet this objective by creating an environment where data is electronically captured near the source and readily available to all areas of the organization. Advanced networks, together with related information system technology, are the enabling mechanisms that make modern information system infrastructures possible. The intent of this paper is to present an overview of advanced information system network technology to support depot modernization planners in making technology management decisions. Existing and emerging Open System Interconnection (OSI) and Government Open System Interconnection Profile (GOSIP) standards are explained, as well as a brief assessment of existing products compliant with these standards. Finally, recommendations for achieving plant-wide integration using existing products are presented, and migration strategies for full OSI compliance are introduced. 5 refs., 16 figs. (JF)

  2. Stock Funding of Depot Level Reparable Components.

    DTIC Science & Technology

    1980-05-01

    PRON ). DESCOM then programs the workload into the appropriate maintenance depot(s), using a fixed price concept based upon actual previous costs...work load 12. Revise outstanding AIF PRONS as required X X X X 13. NOTIFY Congress of proposed budget X X X changes 14. Develop appropriate credit return rates x X X x G -2 ~I

  3. Enhanced Competition: Shaping the Depots after Next.

    DTIC Science & Technology

    2007-11-02

    Staff Analyst, Office of Business Planning , Joint Depot Maintenance Analysis Group, telephone interview by author, 7 February 1998. 39Deutsch...Technology, 11 March 1996, 49-50. Jenkinson, Dave, Staff Analyst, Office of Business Planning , Joint Depot Maintenance Analysis Group. Telephone interview

  4. Space Transportation Infrastructure Supported By Propellant Depots

    NASA Technical Reports Server (NTRS)

    Smitherman, David; Woodcock, Gordon

    2012-01-01

    A space transportation infrastructure is described that utilizes propellant depot servicing platforms to support all foreseeable missions in the Earth-Moon vicinity and deep space out to Mars. The infrastructure utilizes current expendable launch vehicle (ELV) systems such as the Delta IV Heavy, Atlas V, and Falcon 9, for all crew, cargo, and propellant launches to orbit. Propellant launches are made to Low-Earth-Orbit (LEO) Depot and an Earth-Moon Lagrange Point 1 (L1) Depot to support a new reusable in-space transportation vehicles. The LEO Depot supports missions to Geosynchronous Earth Orbit (GEO) for satellite servicing and to L1 for L1 Depot missions. The L1 Depot supports Lunar, Earth-Sun L2 (ESL2), Asteroid and Mars Missions. New vehicle design concepts are presented that can be launched on current 5 meter diameter ELV systems. These new reusable vehicle concepts include a Crew Transfer Vehicle (CTV) for crew transportation between the LEO Depot, L1 Depot and missions beyond L1; a new reusable lunar lander for crew transportation between the L1 Depot and the lunar surface; and Mars orbital Depot are based on International Space Station (ISS) heritage hardware. Data provided includes the number of launches required for each mission utilizing current ELV systems (Delta IV Heavy or equivalent) and the approximate vehicle masses and propellant requirements. Also included is a discussion on affordability with ideas on technologies that could reduce the number of launches required and thoughts on how this infrastructure include competitive bidding for ELV flights and propellant services, developments of new reusable in-space vehicles and development of a multiuse infrastructure that can support many government and commercial missions simultaneously.

  5. Storage depot for radioactive material

    DOEpatents

    Szulinski, Milton J.

    1983-01-01

    Vertical drilling of cylindrical holes in the soil, and the lining of such holes, provides storage vaults called caissons. A guarded depot is provided with a plurality of such caissons covered by shielded closures preventing radiation from penetrating through any linear gap to the atmosphere. The heat generated by the radioactive material is dissipated through the vertical liner of the well into the adjacent soil and thus to the ground surface so that most of the heat from the radioactive material is dissipated into the atmosphere in a manner involving no significant amount of biologically harmful radiation. The passive cooling of the radioactive material without reliance upon pumps, personnel, or other factor which might fail, constitutes one of the most advantageous features of this system. Moreover this system is resistant to damage from tornadoes or earthquakes. Hermetically sealed containers of radioactive material may be positioned in the caissons. Loading vehicles can travel throughout the depot to permit great flexibility of loading and unloading radioactive materials. Radioactive material can be shifted to a more closely spaced caisson after ageing sufficiently to generate much less heat. The quantity of material stored in a caisson is restricted by the average capacity for heat dissipation of the soil adjacent such caisson.

  6. DEPOT database: Reference manual and user's guide

    SciTech Connect

    Clancey, P.; Logg, C.

    1991-03-01

    DEPOT has been developed to provide tracking for the Stanford Linear Collider (SLC) control system equipment. For each piece of equipment entered into the database, complete location, service, maintenance, modification, certification, and radiation exposure histories can be maintained. To facilitate data entry accuracy, efficiency, and consistency, barcoding technology has been used extensively. DEPOT has been an important tool in improving the reliability of the microsystems controlling SLC. This document describes the components of the DEPOT database, the elements in the database records, and the use of the supporting programs for entering data, searching the database, and producing reports from the information.

  7. Interfacial instabilities and fingering formation in Hele-Shaw flow

    NASA Astrophysics Data System (ADS)

    Xu, Jian-Jun

    1996-10-01

    The interfacial instability of Hele-Shaw flow has been a crucial issue for the understanding of the pattern formation of viscous fingers in a Hele-Shaw cell. By using a unified asymptotic approach, we derive two different types of instability mechanisms for slightly' time-dependent finger solutions; namely, (i) the global-trapped-wave (GTW) instability; and (ii) the zero-frequency (null-f) instability. On the basis of these instability mechanisms, the selection of viscous finger formation is clarified; the apparent contradiction between the previous linearstability analysis by Tanveer (1987, Phys. Fluid 30, 1589) and others and the numerical simulations by DeGregoria & Schwartz (1986, J. Fluid Mech. 164, 383)and the experimental evidence is reconciled.

  8. Suppression of viscous fingering in nonflat Hele-Shaw cells

    NASA Astrophysics Data System (ADS)

    Brandão, Rodolfo; Fontana, João V.; Miranda, José A.

    2014-11-01

    Viscous fingering formation in flat Hele-Shaw cells is a classical and widely studied fluid mechanical problem. Recently, instead of focusing on the development of the fingering instability, researchers have devised different strategies aiming to suppress its appearance. In this work, we study a protocol that intends to inhibit the occurrence of fingering instabilities in nonflat (spherical and conical) Hele-Shaw cell geometries. By using a mode-coupling theory to describe interfacial evolution, plus a variational controlling technique, we show that viscous fingering phenomena can be minimized in such a confined, curved environment by properly manipulating a time-dependent injection flow rate Q (t ) . Explicit expressions for Q (t ) are derived for the specific cases of spherical and conical cells. The suitability of the controlling method is verified for linear and weakly nonlinear stages of the flow.

  9. Premixed-Gas Flame Propagation in Hele-Shaw Cells

    NASA Technical Reports Server (NTRS)

    Sharif, J.; Abid, M.; Ronney, P. D.

    1999-01-01

    It is well known that buoyancy and thermal expansion affect the propagation ra and shapes of premixed gas flames. The understanding of such effects is complicated by the large density ratio between the reactants and products, which induces a baroclinic production of vorticity due to misalignment of density and pressure gradients at the front, which in turn leads to a complicated multi-dimensional flame/flow interaction. The Hele-Shaw cell, i.e., the region between closely-spaced flat parallel plates, is probably the simplest system in which multi-dimensional convection is presents consequently, the behavior of fluids in this system has been studied extensively (Homsy, 1987). Probably the most important characteristic of Hele-Shaw flows is that when the Reynolds number based on gap width is sufficiently small, the Navier-Stokes equations averaged over the gap reduce to a linear relation, namely a Laplace equation for pressure (Darcy's law). In this work, flame propagation in Hele-Shaw cells is studied to obtain a better understanding of buoyancy and thermal expansion effects on premixed flames. This work is also relevant to the study of unburned hydrocarbon emissions produced by internal combustion engines since these emissions are largely a result of the partial burning or complete flame quenching in the narrow, annular gap called the "crevice volume" between the piston and cylinder walls (Heywood, 1988). A better understanding of how flames propagate in these volumes through experiments using Hele-Shaw cells could lead to identification of means to reduce these emissions.

  10. Space Resource Requirements for Future In-Space Propellant Production Depots

    NASA Technical Reports Server (NTRS)

    Smitherman, David; Fikes, John; Roy, Stephanie; Henley, Mark W.; Potter, Seth D.; Howell, Joe T. (Technical Monitor)

    2001-01-01

    In 2000 and 2001 studies were conducted at the NASA Marshall Space Flight Center on the technical requirements and commercial potential for propellant production depots in low Earth orbit (LEO) to support future commercial, NASA, and other Agency missions. Results indicate that propellant production depots appear to be technically feasible given continued technology development, and there is a substantial growing market that depots could support. Systems studies showed that the most expensive part of transferring payloads to geosynchronous orbit (GEO) is the fuel. A cryogenic propellant production and storage depot stationed in LEO could lower the cost of missions to GEO and beyond. Propellant production separates water into hydrogen and oxygen through electrolysis. This process utilizes large amounts of power, therefore a depot derived from advanced space solar power technology was defined. Results indicate that in the coming decades there could be a significant demand for water-based propellants from Earth, moon, or asteroid resources if in-space transfer vehicles (upper stages) transitioned to reusable systems using water based propellants. This type of strategic planning move could create a substantial commercial market for space resources development, and ultimately lead toward significant commercial infrastructure development within the Earth-Moon system.

  11. In-Space Cryogenic Propellant Depot Potential Commercial and Exploration Applications

    NASA Technical Reports Server (NTRS)

    Howell, Joe T.; Fikes, John C.; Henley, Mark W.

    2006-01-01

    The key goals and objectives for an In-Space Cryogenic Propellant Depot are to support a safe, reliable, affordable and effective future human and robotic space exploration initiative. Previous studies have been conducted at the NASA Marshall Space Flight Center to determine technical requirements and feasibility for exploration and commercial potential of an in-space cryogenic propellant depot in low-Earth-orbit (LEO), low-Lunar orbit (LLO) and/or on the lunar surface. Results indicate that in-space cryogenic propellant depots are technically feasible given continued technology development and that there is a substantial growing market that depots could support. Systems studies showed that the most expensive part of transferring payloads to geo-synchronous-orbit (GEO) is the fuel. A cryogenic propellant production and storage depot stationed in LEO could lower the cost of missions to GEO and beyond. Propellant production separates water into hydrogen and oxygen through electrolysis. This process requires large amounts of power which is enabled by Space Solar Power technologies. Recent analysis indicate that in the coming decades there could be a significant demand for water-based propellants from Earth, moon, or asteroid resources if in-space transfer vehicles (upper stages) transitioned to reusable systems using water based propellants. This type of strategic planning move could create a substantial commercial market for space resources development, and ultimately lead toward significant commercial infrastructure development within the Earth-Moon system.

  12. Long waves in parallel flow in Hele-Shaw cells

    SciTech Connect

    Zeybek, M.; Yortsos, Y.C.

    1991-04-01

    During the past several years the flow of immiscible flow in Hele-Shaw cells and porous media has been investigated extensively. Of particular interest to most studies has been frontal displacement, specifically viscous fingering instabilities and finger growth. The practical ramifications regarding oil recovery, as well as many other industrial processes in porous media, have served as the primary driving force for most of these investigations. By contrast, little attention has been paid to the motion of lateral fluid interface, which are parallel to the main flow direction. Parallel flow is an often encountered, although much overlooked regime. The evolution of fluid interfaces in parallel flow in Hele-Shaw cells is studied both theoretically and experimentally in the large capillary number limit. It is shown that such interfaces support wave motion, the amplitude of which for long waves is governed by the KdV equation. Experiments are conducted in a long Hele-Shaw cell that validate the theory in the symmetric case. 35 refs., 16 figs.

  13. Depot Maintenance: Improved Strategic Planning Needed to Ensure That Army and Marine Corps Depots Can Meet Future Maintenance Requirements

    DTIC Science & Technology

    2009-09-01

    of Representatives DEPOT MAINTENANCE Improved Strategic Planning Needed to Ensure That Army and Marine Corps Depots Can Meet Future...Depot Maintenance. Improved Strategic Planning Needed to Ensure That Army and Marine Corps Depots Can Meet Future Maintenance Requirements 5a... Strategic Planning Needed to Ensure That Army and Marine Corps Depots Can Meet Future Maintenance Requirements Highlights of GAO-09-865, a report to

  14. Acquired haemophilia in recipients of depot thioxanthenes.

    PubMed

    Stewart, A J; Manson, L M; Dasani, H; Beddall, A; Collins, P; Shima, M; Ludlam, C A

    2000-11-01

    We present two cases in which the occurrence of acquired haemophilia is associated with the use of depot preparations of the thioxanthenes zuclopenthixol and flupenthixol. These drugs have not previously been implicated in the aetiology of acquired haemophilia.

  15. Space propulsion technology and cryogenic fluid depot

    NASA Technical Reports Server (NTRS)

    Diehl, Larry A.

    1988-01-01

    Information on space propulsion and technology and the cryogenic fluid depot is given in viewgraph form. Information is given on orbit transfer, electric propulsion, spacecraft propulsion, and program objectives.

  16. Orbiting propellant depot safety. Volume 3: Appendices

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Appendices to support the findings of the Orbiting Propellant Depot Safety study are presented. The subjects discussed are ullage control subsystems, evaluation of methods, propellant transfer, and baseline subsystem selection.

  17. Depot -- Drug Education Program for Oregon Teachers

    ERIC Educational Resources Information Center

    Schlaadt, Richard G.

    1974-01-01

    Depot was designed to provide teachers with a general understanding of the drug scene, implement the new state drug education guide, distribute and implement drug resources, and stimulate local school drug education programs. (Author)

  18. Defense Depot Tracy Total Quality Management Plan

    DTIC Science & Technology

    1989-07-01

    PAGES TQM ( Total Quality Management ), Depot Operations, Continuous Process Improvement 16. PRICE CODE 17. SECURITY CLASSIFICATION 18. SECURITY...make up our pcrceptions of Total Quality Management . Our goal is to improve those proven management processes that have brought us success while being...MANIAGEMENT F. QUALITY AUDITS OF PRODUCTS AND OPERATIONS ASSETS MANAGEMENT 00 i .......... / ~899 29 03 1 EFENSE DEPOT TACY TOTAL QUALITY MANAGEMENT PLAN

  19. Bulk elastic fingering instability in Hele-Shaw cells.

    PubMed

    Saintyves, B; Dauchot, O; Bouchaud, E

    2013-07-26

    We demonstrate experimentally the existence of a purely elastic, nonviscous fingering instability which arises when air penetrates into an elastomer confined in a Hele-Shaw cell. Fingers appear sequentially and propagate within the bulk of the material as soon as a critical strain, independent of the elastic modulus, is exceeded. Key elements in the driving force of the instability are the confinement of the gel and its adhesion to the plates of the cell, which result in a considerable expense of elastic energy during the growth of the air bubble.

  20. A dynamical mother body in a Hele-Shaw problem

    NASA Astrophysics Data System (ADS)

    Savina, T. V.; Nepomnyashchy, A. A.

    2011-07-01

    It is well-known that in the framework of the internal Hele-Shaw problem the fluid cannot be fully removed through a single point sink because of a cusp formation occurring prior to the moving boundary reaching the sink unless the initial domain is a circle with a sink located in its center. We give a definition of a dynamical mother body and use it for developing an algorithm of complete removal of a fluid droplet having an algebraic boundary. To illustrate our theory we consider examples where fluid can be completely removed through the sinks distributed along arcs of curves and/or points.

  1. Insulin depot formation in subcutaneoue tissue.

    PubMed

    Jockel, James P Leuenberger; Roebrock, Philipp; Shergold, Oliver A

    2013-01-01

    The size and geometry of an insulin depot that is formed during subcutaneous administration by an insulin pump is evaluated. A novel method is used to visualize accurately the depot formation for small volumes of insulin (of the order of 10-100 µl) at a given point in time. Conventional visualization methods such as magnetic resonance imaging are unable to provide such accurate measurements because of their coarse imaging resolution and long measurement time. The described method consists of subcutaneously infusing dyed insulin into porcine tissue and subsequently shock freezing it with liquid nitrogen. The frozen sample is then sliced into thin layers using a cryomicrotome. A digital image of each layer is taken and then processed with proprietary software, which identifies the dyed areas on each layer and reconstructs a three-dimensional model of the insulin depot with a planar resolution of 30 × 30 µm(2) and a depth resolution of 100 µm. Since this process is not viable for living organisms, porcine tissue was used immediately following slaughter of the animal. To date, it is most often assumed that the insulin depot takes the shape of a sphere around the tip of the cannula (e.g., 50 µl insulin equates to a spherical radius of 2.3 mm). However, in practice, such a depot form is never observed. Instead, the insulin depot initially spreads laterally (i.e., parallel) to the skin surface and in the collagen matrix that binds the adipose cells together. The depot outreach increases with larger infused volumes, e.g., maximum outreach measured at 5.0/5.7/7.1 mm (quartiles, n = 17) for 50 µl of infused insulin. Beyond a given infused volume (approximately 100 µl), the insulin also starts to spread perpendicular to the skin surface. It is concluded that formation of the insulin depot depends on the opening of channels at the boundaries between adipose cells. Hence the insulin follows a path of least resistance and depot formation is determined by the local

  2. Injectable controlled release depots for large molecules

    PubMed Central

    Schwendeman, Steven P.; Shah, Ronak B.; Bailey, Brittany A.; Schwendeman, Anna S.

    2014-01-01

    Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen highly successful pharmaceutical products. Until now, success has been limited to several small molecules and peptides, although remarkable improvements have been accomplished in some of these cases. For example, twice-a-year depot injections with leuprolide are available compared to the once-a-day injection of the solution dosage form. Injectable depots are typically prepared by encapsulation of the drug in poly(lactic-co-glycolic acid) (PLGA), a polymer that is used in children every day as a resorbable suture material, and therefore, highly biocompatible. PLGAs remain today as one of the few “real world” biodegradable synthetic biomaterials used in US FDA-approved parenteral long-acting-release (LAR) products. Despite their success, there remain critical barriers to the more widespread use of PLGA LAR products, particularly for delivery of more peptides and other large molecular drugs, namely proteins. In this review, we describe key concepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and then use this information to identify key issues impeding greater widespread use of PLGA depots for this class of drugs. Finally, we examine important approaches, particularly those developed in our research laboratory, toward overcoming these barriers to advance commercial LAR development. PMID:24929039

  3. Injectable controlled release depots for large molecules.

    PubMed

    Schwendeman, Steven P; Shah, Ronak B; Bailey, Brittany A; Schwendeman, Anna S

    2014-09-28

    Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen highly successful pharmaceutical products. Until now, success has been limited to several small molecules and peptides, although remarkable improvements have been accomplished in some of these cases. For example, twice-a-year depot injections with leuprolide are available compared to the once-a-day injection of the solution dosage form. Injectable depots are typically prepared by encapsulation of the drug in poly(lactic-co-glycolic acid) (PLGA), a polymer that is used in children every day as a resorbable suture material, and therefore, highly biocompatible. PLGAs remain today as one of the few "real world" biodegradable synthetic biomaterials used in US FDA-approved parenteral long-acting-release (LAR) products. Despite their success, there remain critical barriers to the more widespread use of PLGA LARproducts, particularly for delivery of more peptides and other large molecular drugs, namely proteins. In this review, we describe key concepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and then use this information to identify key issues impeding greater widespread use of PLGA depots for this class of drugs. Finally, we examine important approaches, particularly those developed in our research laboratory, toward overcoming these barriers to advance commercial LAR development.

  4. STS-28 Columbia, OV-102, Commander Shaw aboard T-38A at Ellington Field

    NASA Image and Video Library

    1989-08-05

    STS-28 Columbia, Orbiter Vehicle (OV) 102, Commander Brewster H. Shaw, wearing navy blue flight coveralls and helmet, sits in T-38A forward cockpit. Shaw, along with his fellow crewmembers, is preparing for departure from Ellington Field to Kennedy Space Center (KSC). STS-28, a Department of Defense (DOD) dedicated mission, is scheduled for launch on 08-08-89.

  5. Shaw High School A Case Study in Rural High School Improvement

    ERIC Educational Resources Information Center

    Williams, Doris Terry

    2004-01-01

    Shaw High School is one of two schools making up the Shaw School District. The school is located in an old and once majestic building whose large concrete pillars still stand at the entrance. A small white house across the street holds the district administrative office. Several buildings, detached from the main building, house the cafeteria,…

  6. STS-28 Columbia, OV-102, Commander Shaw aboard T-38A at Ellington Field

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-28 Columbia, Orbiter Vehicle (OV) 102, Commander Brewster H. Shaw, wearing navy blue flight coveralls and helmet, sits in T-38A forward cockpit. Shaw, along with his fellow crewmembers, is preparing for departure from Ellington Field to Kennedy Space Center (KSC). STS-28, a Department of Defense (DOD) dedicated mission, is scheduled for launch on 08-08-89.

  7. Partial elevation view of the Oregon Trunk Railway Freight Depot, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Partial elevation view of the Oregon Trunk Railway Freight Depot, view looking west at south end of east façade - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

  8. Detail perspective view of the Oregon Trunk Railway Freight Depot, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail perspective view of the Oregon Trunk Railway Freight Depot, view looking east at south end of building - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

  9. Partial elevation view of the Oregon Trunk Railway Freight Depot, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Partial elevation view of the Oregon Trunk Railway Freight Depot, view looking west at north end of east façade - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

  10. Perspective view of the Oregon Trunk Railway Freight Depot, view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view of the Oregon Trunk Railway Freight Depot, view looking west at south end of building - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

  11. Partial elevation view of the Oregon Trunk Railway Freight Depot, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Partial elevation view of the Oregon Trunk Railway Freight Depot, view looking west at center of east façade - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

  12. 13. Interior, storage room of depot located at north end, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Interior, storage room of depot located at north end, looking northeast from southwest corner of room - Missouri Pacific Railway Depot, Natches Street (State Highway 15) & Pine Street intersection, northeast corner, Wisner, Franklin Parish, LA

  13. 12. Interior, storage room of depot located at north end, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Interior, storage room of depot located at north end, looking south - Missouri Pacific Railway Depot, Natches Street (State Highway 15) & Pine Street intersection, northeast corner, Wisner, Franklin Parish, LA

  14. 5. General view of depot in context from old rail ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. General view of depot in context from old rail line, looking south - Missouri Pacific Railway Depot, Natches Street (State Highway 15) & Pine Street intersection, northeast corner, Wisner, Franklin Parish, LA

  15. 6. West elevation of depot looking east from old rail ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. West elevation of depot looking east from old rail line - Missouri Pacific Railway Depot, Natches Street (State Highway 15) & Pine Street intersection, northeast corner, Wisner, Franklin Parish, LA

  16. 1. OVERVIEW, LOOKING EAST OF SIDE ELEVATION OF THE DEPOT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. OVERVIEW, LOOKING EAST OF SIDE ELEVATION OF THE DEPOT (RIGHT) WHICH SERVES AS THE HEART OF DIXIE RAILROAD MUSEUM. AT LEFT IS HISTORIC RAILROAD ROLLING STOCK FROM THE MUSEUM'S COLLECTIONS. - Wilton Depot, Ninth Street, Calera, Shelby County, AL

  17. Public-Private Partnerships for Depot-Level Maintenance

    DTIC Science & Technology

    1999-09-01

    reviews public - private partnerships for depot-level maintenance and leases of DoD depot-level facilities. The Services have used a number of authorities to establish these public-private statutory and regulatory authorities.

  18. LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE (HAER No. PA-116). - Philadelphia & Reading Railroad, Reading Depot Bridge, North Sixth Street at Woodward Street, Reading, Berks County, PA

  19. 2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. Philadelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  20. Sustainment: Making it Better. A Focus on Organic Depot Operations

    DTIC Science & Technology

    1999-04-01

    vi Tables Page Table 1 – Example of Internet Use Applied to Depot Operations with User Interface...u. Table 1 – Example of Internet Use Applied to Depot Operations with User Interface Available Potential Financial News Sustainment News News

  1. Refilling drug delivery depots through the blood.

    PubMed

    Brudno, Yevgeny; Silva, Eduardo A; Kearney, Cathal J; Lewin, Sarah A; Miller, Alex; Martinick, Kathleen D; Aizenberg, Michael; Mooney, David J

    2014-09-02

    Local drug delivery depots have significant clinical utility, but there is currently no noninvasive technique to refill these systems once their payload is exhausted. Inspired by the ability of nanotherapeutics to target specific tissues, we hypothesized that blood-borne drug payloads could be modified to home to and refill hydrogel drug delivery systems. To address this possibility, hydrogels were modified with oligodeoxynucleotides (ODNs) that provide a target for drug payloads in the form of free alginate strands carrying complementary ODNs. Coupling ODNs to alginate strands led to specific binding to complementary-ODN-carrying alginate gels in vitro and to injected gels in vivo. When coupled to a drug payload, sequence-targeted refilling of a delivery depot consisting of intratumor hydrogels completely abrogated tumor growth. These results suggest a new paradigm for nanotherapeutic drug delivery, and this concept is expected to have applications in refilling drug depots in cancer therapy, wound healing, and drug-eluting vascular grafts and stents.

  2. Insights on why graphic correlation (Shaw's method) works.

    USGS Publications Warehouse

    Edwards, L.E.

    1984-01-01

    In 1964 A.B.Shaw presented a method of correlating fossilferous sedimentary rocks based on interpretation of graphic plots of first- and last-occurrences of taxa. Because there is no way to determine the true total ranges of fossil taxa, it is instructive to test the accuracy of the method using hypothetical datasets. The dataset used here consists of 16 taxa in six sections with differing known rates of rock accumulation. In all graphs, a single straight-line correlation was a reasonable interpretation. The resulting ranges after the first and third rounds of compositing reproduce the 'true' ranges but with small errors. Slight errors in the positioning of individual correlation lines are more likely to lengthen ranges artificially than to shorten them. Shaw's method works well because, whereas actually sampled ranges will be shorter than true ranges, errors in correlation will be likely to extend some ranges. This or any exercise using simulated data is useful only if the hypothetical situation resembles real geologic situations and if insights derived from the hypothetical dataset provide insights into real situations. The method is only as good as the available data. -Author

  3. Life support and euthanasia, a perspective on Shaw's new perspective.

    PubMed

    Busch, Jacob; Rodogno, Raffaele

    2011-02-01

    It has recently been suggested by Shaw (2007) that the distinction between voluntary active euthanasia, such as giving a patient a lethal overdose with the intention of ending that patient's life, and voluntary passive euthanasia, such as removing a patient from a ventilator, is much less obvious than is commonly acknowledged in the literature. This is argued by suggesting a new perspective that more accurately reflects the moral features of end-of-life situations. The argument is simply that if we consider the body of a mentally competent patient who wants to die, a kind of 'unwarranted' life support, then the distinction collapses. We argue that all Shaw has provided is a perspective that makes the conclusion that there is little distinction between voluntary active euthanasia and voluntary passive euthanasia only seemingly more palatable. In doing so he has yet to convince us that this perspective is superior to other perspectives and thus more accurately reflects the moral features of the situations pertaining to this issue.

  4. Capillary rise in Hele-Shaw models of disordered media.

    PubMed

    Clotet, Xavier; Planet, Ramon; Ortín, Jordi

    2012-07-01

    We study the capillary rise of a viscous liquid in large Hele-Shaw models of disordered media, both analytically and experimentally. Compared to the Fries-Dreyer and Lucas-Washburn solutions for capillary rise with and without gravity, our experimental data reveal a systematic deviation at short and intermediate times. The original pressure balance equation leading to Washburn's results is reformulated in order to include an additional resisting term, proportional to the mean velocity of the front h˙, which appears naturally as a result of the geometry of the cell. Analytical solutions h(t) are found for displacements with and without gravity. These new solutions reproduce the experimental results very accurately in Hele-Shaw cells of constant gap thickness, where the capillary pressure can be approximated by a constant. In cells of fluctuating gap thickness, where the capillary pressure fluctuates in space, a small additional pressure contribution is required. This correction that depends on h˙ is also studied.

  5. Depot Maintenance: Actions Needed to Identify and Establish Core Capability at Military Depots

    DTIC Science & Technology

    2009-05-01

    Assistant Directors; Carleen Bennett; Grace Coleman; Susan Ditto; David Epstein; Chanee Gaskin; Dawn Godfrey ; Katherine Lenane; Shawnda Lindsey; Randy...Neice; Geoffrey Peck; Terry Richardson; and John Trubey made key contributions to this report. Depot Maintenance GAO Contact Acknowledgments

  6. Techno-economic analysis of decentralized biomass processing depots

    DOE PAGES

    Lamers, Patrick; Roni, Mohammad S.; Tumuluru, Jaya S.; ...

    2015-07-08

    Decentralized biomass processing facilities, known as biomass depots, may be necessary to achieve feedstock cost, quantity, and quality required to grow the future U.S. bioeconomy. In this paper, we assess three distinct depot configurations for technical difference and economic performance. The depot designs were chosen to compare and contrast a suite of capabilities that a depot could perform ranging from conventional pelleting to sophisticated pretreatment technologies. Our economic analyses indicate that depot processing costs are likely to range from ~US$30 to US$63 per dry metric tonne (Mg), depending upon the specific technology implemented and the energy consumption for processing equipmentmore » such as grinders and dryers. We conclude that the benefits of integrating depots into the overall biomass feedstock supply chain will outweigh depot processing costs and that incorporation of this technology should be aggressively pursued.« less

  7. Techno-economic analysis of decentralized biomass processing depots.

    PubMed

    Lamers, Patrick; Roni, Mohammad S; Tumuluru, Jaya S; Jacobson, Jacob J; Cafferty, Kara G; Hansen, Jason K; Kenney, Kevin; Teymouri, Farzaneh; Bals, Bryan

    2015-10-01

    Decentralized biomass processing facilities, known as biomass depots, may be necessary to achieve feedstock cost, quantity, and quality required to grow the future U.S. bioeconomy. In this paper, we assess three distinct depot configurations for technical difference and economic performance. The depot designs were chosen to compare and contrast a suite of capabilities that a depot could perform ranging from conventional pelleting to sophisticated pretreatment technologies. Our economic analyses indicate that depot processing costs are likely to range from ∼US$30 to US$63 per dry metric tonne (Mg), depending upon the specific technology implemented and the energy consumption for processing equipment such as grinders and dryers. We conclude that the benefits of integrating depots into the overall biomass feedstock supply chain will outweigh depot processing costs and that incorporation of this technology should be aggressively pursued.

  8. Multiple steady bubbles in a Hele-Shaw channel

    NASA Astrophysics Data System (ADS)

    Green, Christopher; Vasconcelos, Giovani

    2014-11-01

    We construct analytical solutions, in the form of conformal mappings, solving the free boundary problem for the shapes of any finite number of steadily translating bubbles in a Hele-Shaw channel. These solutions can be decomposed into the sum of two analytic functions - corresponding to the complex potentials in the laboratory and co-travelling frames - which conformally map a bounded multiply connected circular domain onto respective degenerate polygonal domains (infinite strips with interior slits of finite-length which are either horizontally or vertically aligned). These functions are obtained using the generalised Schwarz-Christoffel formula for multiply connected domains in terms of the Schottky-Klein prime function. The solutions we have found are very general and make no assumptions on the geometrical arrangement of the bubbles.

  9. Viscoplastic flow in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Balmforth, Neil; Hewitt, Duncan

    2015-11-01

    A theoretical study is presented of the flow of viscoplastic fluid through a Hele-Shaw cell that contains various kinds of obstructions. Circular and elliptical blockages of the cell are considered together with step-wise contractions or expansions in slot width, all within the simplifying approximation of a narrow gap. Specific attention is paid to the flow patterns that develop around the obstacles, particularly any stagnant plugged regions, and the asymptotic limits of relatively small or large yield stress. Periodic arrays of circular contractions or expansions are studied to explore the interference between obstructions. Finally, viscoplastic flow through a cell with randomly roughened walls is examined, and it is shown that constructive interferences of local contractions and expansions leads to a pronounced channelization of the flow. An optimization algorithm based on minimisation of the pressure drop is derived to construct the path of the channels in the limit of relatively large yield stress or, equivalently, relatively slow flow.

  10. Plant-Wide Assessment Report for Shaw Industries, Plant #78; Aiken, SC

    SciTech Connect

    Michael Brown PE, CEM; Matt Soderlund; Bill Meffert PE; Paolo Baldisserotto; Jerry Zolkowski PE, CEM

    2006-04-10

    A plant-wide energy assessment sponsored by the U.S. Department of Energy was conducted at Shaw Industries Group, plant #78 in Aiken, SC. The assessment team consisted of Georgia Tech faculty from the Energy & Environmental Management Center and Shaw personnel from plant #78 and the corporate energy group. The purpose of this assessment was to uncover as many opportunities for saving energy usage and costs using techniques that have been established as best practices in the energy engineering field. In addition, these findings are to be shared with similar plants in Shaw Industries Group to multiply the lessons learned. The findings from this assessment are included in this report.

  11. The Shaw meteorite - History of a chondrite consisting of impact-melted and metamorphic lithologies

    NASA Technical Reports Server (NTRS)

    Taylor, G. J.; Keil, K.; Berkley, J. L.; Lange, D. E.; Fodor, R. V.

    1979-01-01

    Three intermingled lithologies are identified in the Shaw L-group chondrite: a light-colored lithology with a poikilitic texture, consisting of olivine and augite crystals surrounded by larger orthopyroxene grains; a dark-colored lithology containing remnant chondrules and exhibiting a microgranular texture; and a gray lithology which appears to be intermediate between the other two. Contrary to published opinions, the Shaw meteorite contains normal L-group chondrite abundances of metal and troilite, though these phases are irregularly distributed. The lithological analyses suggest that 4.52 Byr ago an impact took place on the L-group chondrite parent object of Shaw.

  12. Best Practices Case Study: Shaw Construction Burlingame Ranch Ph.1, Aspen, CO

    SciTech Connect

    Pacific Northwest National Laboratory & Oak Ridge National Laboratory

    2010-12-01

    Shaw Construction built 84 energy efficient, affordable condominiums forthe City of Aspen that achieved HERS scores of less than 62 with help from Building America’s research team lead Building Science Corporation.

  13. Public-Private Partnerships at Air Force Maintenance Depots

    DTIC Science & Technology

    2010-06-10

    Report No. D-2010-067 June 10, 2010 Public - Private Partnerships at Air Force Maintenance Depots Report...2. REPORT TYPE 3. DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Public - Private Partnerships at Air Force Maintenance Depots 5a...June 10, 2010 i Results in Brief: Public - Private Partnerships at Air Force Maintenance Depots What We Did We

  14. Lake Billy Shaw Operations and Maintenance, Final Annual Report 2000.

    SciTech Connect

    Dodson, Guy; Pero, Vincent

    2002-01-01

    Lake Billy Shaw is a newly constructed earthen dam reservoir with a surface area of 430 acres. Construction on the dam and structures was complete in November of 1998. The fish screen structures were complete in December of 1998, with initial filling in May 1999. Upon initial filling, dam structures, monitoring wells, fish screen structures, and lake level were monitored daily, with recordings being taken three times/week. During June 1999 the water to the lake was turned off in order to complete additional construction work on the lake. This work included installation of culverts around the perimeter road, installation of boat launches, finish work on the spillway structure, pumphouse and well protection and planting 4 trees along the entrance to the boat launch area. The water was turned on again in late September 1999 with all structures having been checked, fish screens greased and maintained and well levels being monitored. In 2000 the Operations and Maintenance portion of the project began with monitoring of piezometers, water levels, biological monitoring, riparian plantings, protection of shorelines, and maintenance of structures and appurtances.

  15. Bubble dynamics in a variable gap Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Piedra, Saul; Domiguez, Roberto; Ramos, Eduardo

    2015-11-01

    We present observations of the dynamics of individual air bubbles ascending in a Hele-Shaw cell filled with water. Cells with gaps of 1 mm, 1.5 and 2.5 mm are used and the volume of the bubbles is such that we observe bubbles with apparent diameter from 2 mm to 7.3 mm. Given that we work with air and water in all experiments, the Morton number is constant and equal to 2 . 5 ×10-11 . The results are given in terms of the Eotvos, Archimedes and Reynolds numbers, and the trajectories and wakes of the bubbles are described as functions of the gap. In all cases we observe a linear relationship between the Reynolds and Archimedes numbers, but the proportionality constant varies with the gap. Also, although the wake is composed of alternating vortices similar to the von Karman vortex street, the size and location of the vortices vary with the gap. The analysis of some features of the observations and the description of the shape of the bubbles and dominant forces are made with a two dimensional numerical solution of the conservation equations using a front tracking strategy.

  16. DoD Depot-Level Reparable Supply Chain Management: Process Effectiveness and Opportunities for Improvement

    DTIC Science & Technology

    2014-01-01

    Logistics Complex AMC Army Materiel Command AMCOM Aviation and Missile Life Cycle Management Command ANAD Anniston Army Depot AOIB Army Organic...Complex (ALC) (supply and maintenance), Oklahoma City ALC (supply and maintenance), Warner Robins ALC (supply), Anniston Army Depot, Corpus Christi...NIINs NOTE: CCAD = Corpus Christi Army Depot, TYAD = Tobyhanna Army Depot, LEAD = Letterkenny Army Depot, ANAD = Anniston Army Depot. RAND RR398-4.1 C

  17. Improving Air Force Depot Programming by Linking Resources to Capabilities

    DTIC Science & Technology

    2012-01-01

    Maintenance Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Mathematical Formulation of the Depot Purchased Equipment...basis for the similitude of capability across these business areas and a quantitative anchor for programming trades. Anecdotal information indicates that... mathematical formulation. Description of the Depot Purchased Equipment Maintenance Model The requirements process designates, for each year in the FYDP, a number

  18. Fatty acid composition of fat depots in wintering Canada geese

    USGS Publications Warehouse

    Austin, J.E.

    1993-01-01

    I determined the fatty acid composition of subcutaneous, abdominal, visceral, and leg saddle depots in adult female Canada Geese (Branta canadensis) wintering in north-central Missouri during October 1984-March 1985. Mean levels of C14:0, C16:0, C16:1, C18:0, C18:1, C18:2, and C18:3 generally were highest in the subcutaneous and abdominal depots. The ratio of saturated to unsaturated fats was highest in the leg saddle depot and lowest in the abdominal depot. I also assessed the differences among sexes, seasons, and years in fatty acid composition of abdominal fat depots in adult geese collected during October-March, 1985-1987. Adult females had consistently higher levels of C14:0 in abdominal depots than males. Fatty acid composition of the abdominal depot differed among years but not by season. In the abdominal depot, C14:0, C16:0, C16:1, and C18:1 were higher in 1986-1987 compared with the previous two years, whereas C18:3 was highest in 1984-1985. Differences among years reflected changes in winter diet. Fatty acids of wintering geese were similar to those previously found in breeding Canada Geese.

  19. Enhanced mixing via alternating injection in radial Hele-Shaw flows.

    PubMed

    Chen, Ching-Yao; Huang, Yi-Cheng; Huang, Yu-Sheng; Miranda, José A

    2015-10-01

    Mixing at low Reynolds numbers, especially in the framework of confined flows occurring in Hele-Shaw cells, porous media, and microfluidic devices, has attracted considerable attention lately. Under such circumstances, enhanced mixing is limited due to the lack of turbulence, and absence of sizable inertial effects. Recent studies, performed in rectangular Hele-Shaw cells, have demonstrated that the combined action of viscous fluid fingering and alternating injection can dramatically improve mixing efficiency. In this work, we revisit this important fluid mechanical problem, and analyze it in the context of radial Hele-Shaw flows. The development of radial fingering instabilities under alternating injection conditions is investigated by intensive numerical simulations. We focus on the impact of the relevant physical parameters of the problem (Péclet number Pe, viscosity contrast A, and injection time interval Δt) on fluid mixing performance.

  20. Inertia-induced dendriticlike patterns in lifting Hele-Shaw flows

    NASA Astrophysics Data System (ADS)

    Anjos, Pedro H. A.; Dias, Eduardo O.; Miranda, José A.

    2017-01-01

    The lifting Hele-Shaw cell problem is a variant of the classical constant-gap Hele-Shaw situation in which the cell gap width is time dependent. Experiments on Newtonian fluid flows in lifting Hele-Shaw cells with large lifting velocities reveal the development of dendriticlike fingered structures that compete among themselves. The usual Darcy law description of the problem, where inertial effects are neglected, has not been able to explain the origin of these competing sidebranched patterns. In this work we use a generalized Darcy law and a perturbative mode-coupling theory to investigate the impact of inertia on the pattern-forming dynamics of the system. Two main results are deduced: Inertia induces a mechanism for finger sidebranching formation and favors the intensification of finger competition events.

  1. Examination of adipose depot-specific PPAR moieties

    SciTech Connect

    Dodson, M.V.; Vierck, J.L.; Hausman, G.J.; Guan, L.L.; Fernyhough, M.E.; Poulos, S.P.; Mir, P.S.; Jiang, Z.

    2010-04-02

    Molecular mechanisms of peroxisome proliferator activated receptors (PPARs) are being defined rapidly, as illustrated by the volume of papers published. Much of the research is directed towards a clinical end-point/application; however, the non-homogeneous nature of adipose depots in laboratory animals is spurring similar research in domestic meat animals (such as beef cattle). Moreover, the size of adipose depots in meat animals remains an attractive feature for using them to obtain cells for PPAR research. Examination of meat-animal depot-specific PPAR moieties may provide novel information about adipocyte regulation that might be extrapolated to all animals.

  2. Examination of adipose depot-specific PPAR moieties.

    PubMed

    Dodson, M V; Vierck, J L; Hausman, G J; Guan, L L; Fernyhough, M E; Poulos, S P; Mir, P S; Jiang, Z

    2010-04-02

    Molecular mechanisms of peroxisome proliferator activated receptors (PPARs) are being defined rapidly, as illustrated by the volume of papers published. Much of the research is directed towards a clinical end-point/application; however, the non-homogeneous nature of adipose depots in laboratory animals is spurring similar research in domestic meat animals (such as beef cattle). Moreover, the size of adipose depots in meat animals remains an attractive feature for using them to obtain cells for PPAR research. Examination of meat-animal depot-specific PPAR moieties may provide novel information about adipocyte regulation that might be extrapolated to all animals. 2010 Elsevier Inc. All rights reserved.

  3. Abarelix: abarelix-depot-F, abarelix-depot-M, abarelix-L, PPI 149, R 3827.

    PubMed

    2003-01-01

    Abarelix [Abarelix-Depot-F, Abarelix-Depot-M, Abarelix-L, PPI 149, R 3827, Plenaxis] is a peptide consisting of natural and artificial amino acids. In females, abarelix is an estrogen production antagonist with potential for the treatment of breast cancer, endometriosis and other reproductive hormone diseases. In males it is a testosterone production antagonist and has potential as hormonal therapy of prostate cancer. Depot formulations of abarelix (abarelix-depot-M and abarelix-depot-F) are being developed for hormonally responsive prostate cancer and endometriosis, respectively. Clinical development of the depot formulations is currently being conducted by Praecis Pharmaceuticals, the originators of the agent. A non-depot formulation, abarelix-L, was also being conducted for prostate gland volume reduction. Praecis Pharmaceuticals has entered into a number of licensing agreements covering abarelix. However, all agreements have since been terminated leaving Praecis to develop and commercialise the agent on its own. The terminated agreements include an agreement between Praecis and Roche for the commercialisation of abarelix in the US. This agreement was terminated in November 1998. Praecis Pharmaceuticals also entered into a collaborative agreement with Amgen in March 1999, whereby the companies would develop abarelix and Amgen would commercialise the drug in the US, Canada, Australia, Asia and several secondary markets. However, in September 2001, Praecis and Amgen announced that they were terminating the agreement for all indications. Praecis stated at the time that it remained committed to developing abarelix for both prostate cancer and endometriosis. Amgen had submitted 'Lotestrol' to the US Patent and Trademarks Office as a possible tradename for abarelix-depot-M. Lotestrol may also have been under consideration as a tradename for abarelix-depot-F. Praecis had also sold European, African, Latin American and Middle Eastern rights to abarelix to Sanofi

  4. Where Do Interjections Come From? A Psycholinguistic Analysis of Shaw's "Pygmalion"

    ERIC Educational Resources Information Center

    O'Connell, Daniel C.; Kowal, Sabine

    2005-01-01

    Starting from our recent findings regarding emotional and initializing functions of interjections in TV and radio interviews (Kowal & O'Connell, 2004b; O'Connell & Kowal, in press; O'Connell, Kowal, & Ageneau, 2005), we used the book and script of Shaw (1916/1969) and the audiotape of the motion picture (Pascal, Asquith, & Howard, 1938) Pygmalion…

  5. R.D. Lawrence, H.G. Wells, G.B. Shaw: a vignette.

    PubMed

    Jackson, J G

    1996-05-01

    Among the unpublished autobiographical notes of Dr R.D. Lawrence are numerous references to his contacts and friendship with the author H.G. Wells, who was to become the first President of the (British) Diabetic Association. Wells was responsible for Lawrence being called in for consultation by George Bernard Shaw, a meeting which was to have surprising consequences.

  6. Where Do Interjections Come From? A Psycholinguistic Analysis of Shaw's "Pygmalion"

    ERIC Educational Resources Information Center

    O'Connell, Daniel C.; Kowal, Sabine

    2005-01-01

    Starting from our recent findings regarding emotional and initializing functions of interjections in TV and radio interviews (Kowal & O'Connell, 2004b; O'Connell & Kowal, in press; O'Connell, Kowal, & Ageneau, 2005), we used the book and script of Shaw (1916/1969) and the audiotape of the motion picture (Pascal, Asquith, & Howard, 1938) Pygmalion…

  7. Capillary and geometrically driven fingering instability in nonflat Hele-Shaw cells

    NASA Astrophysics Data System (ADS)

    Brandão, Rodolfo; Miranda, José A.

    2017-03-01

    The usual viscous fingering instability arises when a fluid displaces another of higher viscosity in a flat Hele-Shaw cell, under sufficiently large capillary number conditions. In this traditional framing, the reverse flow case (more viscous fluid displacing a less viscous one) and the viscosity-matched situation (fluids of equal viscosities) are stable. We revisit this classical fluid dynamic problem, now considering flow in a nonflat Hele-Shaw cell. For a specific nonflat environment, we show that both the reverse and the viscosity-matched flows can become unstable, even at low capillary number. This peculiar fluid fingering instability is driven by the combined action of capillary effects and geometric properties of the nonflat Hele-Shaw cell. Our theoretical results indicate that the Hele-Shaw cell geometry significantly impacts the linear stability and nonlinear pattern-forming dynamics of the system. This suggests that the geometry of the medium plays an important role in favoring the occurrence of fingering patterns in nonflat, confined fluid flows.

  8. Frank Parsons's Enablers: Pauline Agassiz Shaw, Meyer Bloomfield, and Ralph Albertson

    ERIC Educational Resources Information Center

    Hershenson, David B.

    2006-01-01

    Frank Parsons was not the 1st American to recognize or address the need for vocational guidance. Why he, rather than his predecessors, is credited with initiating the field can be attributed to the largely overlooked contributions of 3 other persons: Pauline Agassiz Shaw, Meyer Bloomfield, and Ralph Albertson. The author calls attention to the…

  9. Frank Parsons's Enablers: Pauline Agassiz Shaw, Meyer Bloomfield, and Ralph Albertson

    ERIC Educational Resources Information Center

    Hershenson, David B.

    2006-01-01

    Frank Parsons was not the 1st American to recognize or address the need for vocational guidance. Why he, rather than his predecessors, is credited with initiating the field can be attributed to the largely overlooked contributions of 3 other persons: Pauline Agassiz Shaw, Meyer Bloomfield, and Ralph Albertson. The author calls attention to the…

  10. Save Energy Now Assessment Helps Expand Energy Management Program at Shaw Industries

    SciTech Connect

    2008-07-01

    The Shaw Industries carpet manufacturing plant #20 in Dalton, Georgia, optimized boiler operation and installed waste heat exchangers on two processes in the dye house and an economizer on one boiler, for a payback of 1.7 years. These results prompted plant #4, also located in Dalton, to participate in an assessment.

  11. Radiological Final Status Survey of the Hammond Depot, Hammond, Indiana

    SciTech Connect

    T.J. Vitkus

    2008-04-07

    ORISE conducted extensive scoping, characterization, and final status surveys of land areas and structures at the DNSC’s Hammond Depot located in Hammond, Indiana in multiple phases during 2005, 2006 and 2007.

  12. 18. Historic view of Court Street and Depot Square. Photoengraving ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Historic view of Court Street and Depot Square. Photoengraving from Artwork of Rhode Island (Chicago: W.H. Parish Publishing Co., 1896) view west - Court Street Bridge, Court Street spanning Blackstone River & Truman Drive, Woonsocket, Providence County, RI

  13. 32. Oakland Port and General Depot. Transit Shed No. 7, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 161 TYPICAL SECTION & DETAILS. Sheet 5 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

  14. 33. Oakland Port and General Depot. Transit Shed No. 7, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 STAIR & TOILET ROOM DETAILS. Sheet 6 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

  15. 35. Oakland Port and General Depot. Transit Shed No. 7, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 END WALL FRAMING. Sheet 9 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

  16. 34. Oakland Port and General Depot. Transit Shed No. 7, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 70'0' TRUSS. Sheet 7 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

  17. 30. Oakland Port and General Depot. Transit Shed No. 7, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 161 PLOT PLAN & TRANSVERSE SECTION. Sheet 1 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

  18. 31. Oakland Port and General Depot. Transit Shed No. 7, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 STAIR & TOILET ROOM DETAILS. Sheet 3 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

  19. Use of Depot Antipsychotic Medications for Medication Nonadherence in Schizophrenia

    PubMed Central

    West, Joyce C.; Marcus, Steven C.; Wilk, Joshua; Countis, Lisa M.; Regier, Darrel A.; Olfson, Mark

    2008-01-01

    Objectives: To describe factors associated with initiation of depot antipsychotic medications in psychiatric outpatients with schizophrenia and recent medication nonadherence. Methods: A national sample of psychiatrists reported on adult outpatients with schizophrenia who were nonadherent with oral antipsychotic medications in the last year. Results: In total, 17.6% of psychiatrists initiated depot antipsychotic injections. Initiation was significantly and positively associated with public insurance, prior inpatient admission, proportion of time nonadherent, average or above average intellectual functioning, and living in a mental health residence. Use was inversely associated with using second-generation antipsychotics and other oral psychotropic medications prior to medication nonadherence. Psychiatrists who were male, nonwhite, and more optimistic about managing nonadherence were more likely to initiate depot injections. Conclusions: Initiation of depot injections is a joint function of patient, physician, treatment, and setting factors. Use of long-acting preparations in this population is uncommon despite clinical recommendations urging their use. PMID:18093962

  20. 5. Photocopy titled 'Map of Naval Ammunition Depot, Bremerton (Puget ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy titled 'Map of Naval Ammunition Depot, Bremerton (Puget Sound), Wash.' dated June 30, 1947. Buildings 103 and 104 are shaded and located left of center near top of map. HABS film is an 8x10' high-contrast negative made from original map in the collection of the Department of Public Works, Puget Sound Naval Shipyard, Bremerton, WA. - Puget Sound Naval Shipyard, Munitions Storage Bunker, Naval Ammunitions Depot, North of Campbell Trail, Bremerton, Kitsap County, WA

  1. A Cryogenic Propellant Production Depot for Low Earth Orbit

    NASA Technical Reports Server (NTRS)

    Potter, Seth D.; Henley, Mark W.; Gutierrez, Sonia; Fikes, John; Carrington, Connie; Smitherman, David; Gerry, Mark; Sutherlin, Steve; Beason, Phil; Howell, Joe (Technical Monitor)

    2001-01-01

    The cost of access to space beyond low Earth orbit can be lowered if vehicles can refuel in orbit. The power requirements for a propellant depot that electrolyzes water and stores cryogenic oxygen and hydrogen can be met using technology developed for space solar power. A propellant depot is described that will be deployed in a 400 km circular equatorial orbit, receive tanks of water launched into a lower orbit from Earth by gun launch or reusable launch vehicle, convert the water to liquid hydrogen and oxygen, and store up to 500 metric tonnes of cryogenic propellants. Orbital maneuvering vehicles will transfer the Earth-launched propellant tanks from the lower orbit to the depot orbit. The propellant stored in the depot can support transportation from low Earth orbit to geostationary Earth orbit, the Moon, LaGrange points, Mars, etc. The propellant tanks on the depot are modified versions of those used in the Delta IV-Heavy launch vehicle. The tanks are configured in an in-line gravity-gradient configuration to minimize drag and settle the propellant. Temperatures can be maintained by body-mounted radiators; these will also provide some shielding against orbital debris. Power is supplied by a pair of solar arrays mounted perpendicular to the orbital plane, which rotate once per orbit to track the Sun. The majority of the power will be used to run the electrolysis system. Technology needed for an orbiting propellant depot can be tested and demonstrated in the near-term on the ground, on a Shuttle-deployed free-flyer, and on the International Space Station. Further along, an orbital depot can be deployed that stores liquid hydrogen and oxygen launched from Earth, to be followed by a full conversion and storage depot.

  2. An Organizational Analysis of Marine Corps Recruit Depot, San Diego

    DTIC Science & Technology

    2003-03-01

    WRR Western Recruiting Region MCB Marine Corps Base RTR Recruit Training Regiment H&S BN Headquarters & Service Battalion WFTBN Weapons Field...Corps 38,000 recruits each year, MCRDSD is also responsible for the Western Recruiting Region ( WRR ) headquartered aboard the Depot. This study...the depots primary mission of converting civilians into top -notch, basic trained Marines. This study can be used by Marine Corps leaders, planners

  3. Total Quality Management Implementation Plan: Defense Depot, Ogden

    DTIC Science & Technology

    1989-07-01

    NUMBERS Total Quality Management Implementation Plan Defense Depot Ogden 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING...PAGES TQM ( Total Quality Management ), Continuous Process Improvement, Depot Operations, Process Action Teams 16. PRICE CODE 17. SECURITY...034 A Message From The Commander On Total Quality Management i fully support the DLA aoproacii to Total Quality Management . As stated by General

  4. The evolution of Orbiter depot support, with applications to future space vehicles

    NASA Technical Reports Server (NTRS)

    Mcclain, Michael L.

    1990-01-01

    The reasons for depot consolidation and the processes established to implement the Orbiter depot are presented. The Space Shuttle Orbiter depot support is presently being consolidated due to equipment suppliers leaving the program, escalating depot support costs, and increasing repair turnaround times. Details of the depot support program for orbiter hardware and selected pieces of support equipment are discussed. The benefits gained from this consolidation and the lessons learned are then applied to future reuseable space vehicles to provide program managers a forward look at the need for efficient depot support.

  5. Lanreotide Depot: An Antineoplastic Treatment of Carcinoid or Neuroendocrine Tumors.

    PubMed

    Wolin, Edward M; Manon, Amandine; Chassaing, Christophe; Lewis, Andy; Bertocchi, Laurent; Richard, Joel; Phan, Alexandria T

    2016-12-01

    Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients with unresectable gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and also approved in Europe for symptom control in carcinoid syndrome associated with GEP-NETs. This review discusses how the distinct molecule and formulation of lanreotide depot provide advantages to patients and health care providers, as well as the most recent clinical evidence demonstrating the safety and efficacy of lanreotide depot in inhibiting tumor growth and controlling hormonal symptoms in GEP-NETs. The lanreotide depot formulation confers a remarkable pharmacokinetic profile with no excipients, comprised only of lanreotide acetate and water. Of note, lanreotide depot constitutes an example for peptide self-assembly based formulations, providing insights that could help future development of sustained-release formulations of other antineoplastic peptides. Most patients with GEP-NETs will present with inoperable or incurable disease; thus, medical management for symptoms and tumor control plays a crucial role. Recent long-term clinical studies have demonstrated that lanreotide depot is well tolerated, prolongs PFS in GEP-NET patients, and significantly reduces symptoms related to carcinoid syndrome. The unique depot formulation and delivery method of lanreotide confer advantages in the treatment of metastatic GEP-NETs, contributing to improvements in NET-related symptoms and PFS without reducing quality of life in this patient population.

  6. Determining the number of fingers in the lifting Hele-Shaw problem

    NASA Astrophysics Data System (ADS)

    Miranda, Jose; Dias, Eduardo

    2013-11-01

    The lifting Hele-Shaw cell flow is a variation of the celebrated radial viscous fingering problem for which the upper cell plate is lifted uniformly at a specified rate. This procedure causes the formation of intricate interfacial patterns. Most theoretical studies determine the total number of emerging fingers by maximizing the linear growth rate, but this generates discrepancies between theory and experiments. In this work, we tackle the number of fingers selection problem in the lifting Hele-Shaw cell by employing the recently proposed maximum-amplitude criterion. Our linear stability analysis accounts for the action of capillary, viscous normal stresses, and wetting effects, as well as the cell confinement. The comparison of our results with very precise laboratory measurements for the total number of fingers shows a significantly improved agreement between theoretical predictions and experimental data. We thank CNPq (Brazilian Sponsor) for financial support.

  7. A Hele-Shaw-Cahn-Hilliard Model for Incompressible Two-Phase Flows with Different Densities

    NASA Astrophysics Data System (ADS)

    Dedè, Luca; Garcke, Harald; Lam, Kei Fong

    2017-07-01

    Topology changes in multi-phase fluid flows are difficult to model within a traditional sharp interface theory. Diffuse interface models turn out to be an attractive alternative to model two-phase flows. Based on a Cahn-Hilliard-Navier-Stokes model introduced by Abels et al. (Math Models Methods Appl Sci 22(3):1150013, 2012), which uses a volume-averaged velocity, we derive a diffuse interface model in a Hele-Shaw geometry, which in the case of non-matched densities, simplifies an earlier model of Lee et al. (Phys Fluids 14(2):514-545, 2002). We recover the classical Hele-Shaw model as a sharp interface limit of the diffuse interface model. Furthermore, we show the existence of weak solutions and present several numerical computations including situations with rising bubbles and fingering instabilities.

  8. Generalized elastica patterns in a curved rotating Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Brandão, Rodolfo; Miranda, José A.

    2017-08-01

    We study a family of generalized elasticalike equilibrium shapes that arise at the interface separating two fluids in a curved rotating Hele-Shaw cell. This family of stationary interface solutions consists of shapes that balance the competing capillary and centrifugal forces in such a curved flow environment. We investigate how the emerging interfacial patterns are impacted by changes in the geometric properties of the curved Hele-Shaw cell. A vortex-sheet formalism is used to calculate the two-fluid interface curvature, and a gallery of possible shapes is provided to highlight a number of peculiar morphological features. A linear perturbation theory is employed to show that the most prominent aspects of these complex stationary patterns can be fairly well reproduced by the interplay of just two interfacial modes. The connection of these dominant modes to the geometry of the curved cell, as well as to the fluid dynamic properties of the flow, is discussed.

  9. Genealogy of John and Charles Bell: their relationship with the children of Charles Shaw of Ayr.

    PubMed

    Kaufman, M

    2005-11-01

    The Reverend William Bell had six children who survived infancy. Two of his sons entered the legal profession and two other sons became distinguished anatomists and surgeons--John Bell, said for 20 years to have been the leading operating surgeon in Britain and throughout the world--and Sir Charles Bell, possibly the most distinguished anatomist and physiologist of his day. Information is not known about the fifth son or their sister. Charles Shaw, a lawyer of Ayr, had four sons and two daughters who survived infancy. Two of his sons, John and Alexander, became anatomists and later surgeons at the Middlesex Hospital, and both worked closely with Charles Bell at the Great Windmill Street School of Anatomy. His third son entered the law and his fourth son became a distinguished soldier. The two daughters of Charles Shaw married into the Bell family: Barbara married George Joseph Bell and Marion married Mr (later Sir) Charles Bell.

  10. The Two-Phase Hell-Shaw Flow: Construction of an Exact Solution

    NASA Astrophysics Data System (ADS)

    Malaikah, K. R.

    2013-03-01

    We consider a two-phase Hele-Shaw cell whether or not the gap thickness is time-dependent. We construct an exact solution in terms of the Schwarz function of the interface for the two-phase Hele-Shaw flow. The derivation is based upon the single-valued complex velocity potential instead of the multiple-valued complex potential. As a result, the construction is applicable to the case of the time-dependent gap. In addition, there is no need to introduce branch cuts in the computational domain. Furthermore, the interface evolution in a two-phase problem is closely linked to its counterpart in a one-phase problem

  11. A Cryogenic Propellant Production Depot for Low Earth Orbit

    NASA Technical Reports Server (NTRS)

    Potter, Seth D.; Henley, Mark; Guitierrez, Sonia; Fikes, John; Carrington, Connie; Smitherman, David; Gerry, Mark; Sutherlin, Steve; Beason, Phil; Howell, Joe (Technical Monitor)

    2001-01-01

    The cost of access to space beyond low Earth orbit can be lowered if vehicles can refuel in orbit. The power requirements for a propellant depot that electrolyzes water and stores cryogenic oxygen and hydrogen can be met using technology developed for space solar power. A propellant depot is described that will be deployed in a 400 km circular equatorial orbit, receive tanks of water launched into a lower orbit from Earth by gun launch or reusable launch vehicle, convert the water to liquid hydrogen and oxygen, and store Lip to 500 metric tonnes of cryogenic propellants. The propellant stored in the depot can support transportation from low Earth orbit to geostationary Earth orbit, the Moon, LaGrange points, Mars, etc. The tanks are configured in an inline gravity-gradient configuration to minimize drag and settle the propellant. Temperatures can be maintained by body-mounted radiators; these will also provide some shielding against orbital debris. Power is supplied by a pair of solar arrays mounted perpendicular to the orbital plane, which rotate once per orbit to track the Sun. In the longer term, cryogenic propellant production technology can be applied to a larger LEO depot, as well as to the use of lunar water resources at a similar depot elsewhere.

  12. Triptorelin depot stimulation test for central precocious puberty.

    PubMed

    Strich, David; Kvatinsky, Noa; Hirsch, Harry J; Gillis, David

    2013-01-01

    Acute gonadotropin responses following depot leuprolide acetate injection are useful for monitoring therapeutic efficacy in central precocious puberty. Similar monitoring of therapy in patients treated with another widely used GnRH agonist, depot triptorelin, has not yet been reported. The objective of this study was to test the use of gonadotropin levels after therapeutic injections of depot triptorelin for evaluating efficacy of therapy. Thirty-two patients (29 girls and three boys) were treated with triptorelin depot, 3.75 mg per vial, between 2006 and 2010. Treatment was initiated at 8.27±1.76 years (range, 4.6-11.6 years). Blood was drawn before and at variable times between 30 min and 2 h after injections. Clinical tests were retrospectively collected. After the first injection, the 60-min mean luteinizing hormone (LH) level was 21.6.1±18.0 IU/L and the follicle-stimulating hormone (FSH) was 13.5±3.6 IU/L. After subsequent injections, for those who showed clinical suppression, the standard deviations above the mean were 3.6 IU/L for FSH and 2.1 IU/L for LH. The LH levels of two patients who did not suppress sufficiently were at these limits or higher. Sixty-minute postinjection depot triptorelin levels of LH can be successfully used to evaluate the efficacy of treatment with this agent. Limits for suppressed levels have been determined.

  13. Preliminary assessment of the health and environmental impacts of continuing to store M55 rockets at Lexington-Blue Grass Depot Activity, Anniston Army Depot, Umatilla Depot Activity, Pine Bluff Arsenal, and Tooele Army Depot

    SciTech Connect

    Boyette, J.A.; Breck, J.E.; Coleman, P.R.; Griffin, G.D.; Hillsman, E.L.; Johnson, P.E.; Kornegay, F.C.; Ogles, M.R.; Schweitzer, M.; Sigal, L.L.

    1986-03-01

    The purpose is to provide an assessment of the potential health and environmental impacts of continuing to store M55 rockets filled with nerve agent GB or VX at their current storage locations at Anniston Army Depot in Alabama, Lexington-Blue Grass Depot Activity in Kentucky, Pine Bluff Arsenal in Arkansas, Tooele Army Depot in Utah, and Umatilla Depot Activity in Oregon. The assessment considers the possible impacts of (1) normal storage (with no release to the environment) and (2) two postulated accidents on the air quality, ground and surface water, aquatic ecology, terrestrial ecology, human health, and cultural and socioeconomic resources in and around the various storage depots. The analysis considers three basic scenarios during storage: (1) normal operations; (2) a minor spill of agent (the contents of one rocket released to the biosphere); and (3) a maximum credible event or MCE. The MCE is an igloo fire resulting in the aerosolization of a small (in the case of GB) or an extremely small (in the case of VX) percentage of the igloo's nerve agent contents to the biosphere. The extremely low probabilities of such accidents, which are reported elsewhere, are noted. Our assessments of the impacts of a minor spill and of an MCE consider two sets of meteorological conditions: conservative most likely and worst-case. In addition, we assume that an agent plume would travel toward the area of highest population density. 21 figs., 47 tabs.

  14. In-Space Cryogenic Propellant Depot Stepping Stone

    NASA Technical Reports Server (NTRS)

    Howell, Joe T.; Mankins, John C.; Fikes, John C.

    2005-01-01

    An In-Space Cryogenic Propellant Depot (ISCPD) is an important stepping stone to provide the capability to preposition, store, manufacture, and later use the propellants for Earth-Neighborhood campaigns and beyond. An in-space propellant depot will provide affordable propellants and other similar consumables to support the development of sustainable and affordable exploration strategies as well as commercial space activities. An in-space propellant depot not only requires technology development in key areas such as zero boil-off storage and fluid transfer, but in other areas such as lightweight structures, highly reliable connectors, and autonomous operations. These technologies can be applicable to a broad range of propellant depot concepts or specific to a certain design. In addition, these technologies are required for spacecraft and orbit transfer vehicle propulsion and power systems, and space life support. Generally, applications of this technology require long-term storage, on-orbit fluid transfer and supply, cryogenic propellant production from water, unique instrumentation and autonomous operations. This paper discusses the reasons why such advances are important to future affordable and sustainable operations in space. This paper also discusses briefly R&D objectives comprising a promising approach to the systems planning and evolution into a meaningful stepping stone design, development, and implementation of an In-Space Cryogenic Propellant Depot. The success of a well-planned and orchestrated approach holds great promise for achieving innovation and revolutionary technology development for supporting future exploration and development of space.

  15. Subcritical Kelvin-Helmholtz instability in a Hele-Shaw cell.

    PubMed

    Meignin, L; Gondret, P; Ruyer-Quil, C; Rabaud, M

    2003-06-13

    We investigate experimentally the subcritical behavior of the Kelvin-Helmholtz instability for a gas-liquid shearing flow in a Hele-Shaw cell. The subcritical curve separating the solutions of a stable plane interface and a fully saturated nonlinear wave train is determined. Experimental results are fitted by a fifth order complex Ginzburg-Landau equation whose linear coefficients are compared to theoretical ones.

  16. An evolutionarily conserved mode of modulation of Shaw-like K+ channels

    PubMed Central

    Cotella, Diego; Hernandez-Enriquez, Berenice; Duan, Zhibing; Wu, Xilong; Gazula, Valeswara-Rao; Brown, Maile R.; Kaczmarek, Leonard K.; Sesti, Federico

    2013-01-01

    Voltage-gated K+ channels of the Shaw family (also known as the KCNC or Kv3 family) play pivotal roles in mammalian brains, and genetic or pharmacological disruption of their activities in mice results in a spectrum of behavioral defects. We have used the model system of Caenorhabditis elegans to elucidate conserved molecular mechanisms that regulate these channels. We have now found that the C. elegans Shaw channel KHT-1, and its mammalian homologue, murine Kv3.1b, are both modulated by acid phosphatases. Thus, the C. elegans phosphatase ACP-2 is stably associated with KHT-1, while its mammalian homolog, prostatic acid phosphatase (PAP; also known as ACPP-201) stably associates with murine Kv3.1b K+ channels in vitro and in vivo. In biochemical experiments both phosphatases were able to reverse phosphorylation of their associated channel. The effect of phosphorylation on both channels is to produce a decrease in current amplitude and electrophysiological analyses demonstrated that dephosphorylation reversed the effects of phosphorylation on the magnitude of the macroscopic currents. ACP-2 and KHT-1 were colocalized in the nervous system of C. elegans and, in the mouse nervous system, PAP and Kv3.1b were colocalized in subsets of neurons, including in the brain stem and the ventricular zone. Taken together, this body of evidence suggests that acid phosphatases are general regulatory partners of Shaw-like K+ channels.—Cotella, D., Hernandez-Enriquez, B., Duan, Z., Wu, X., Gazula, V.-R., Brown, M. R., Kaczmarek, L. K., and Sesti, F. An evolutionarily conserved mode of modulation of Shaw-like K+ channels. PMID:23233530

  17. Environmental Assessment for Construction of Physical Security Improvements at Shaw Air Force Base, South Carolina

    DTIC Science & Technology

    2005-10-01

    area on the northeast side of Long Branch would be accomplished by traveling out the North Gate onto Frierson Road and accessing the area through the...in Figure 2-5, security forces would have to travel approximately ¾ of a mile further to reach the area north of the Long Branch. The additional... manufactured features that constitute the aesthetic qualities of an area. The ROI for land use and visual resources is Shaw AFB. 3.1.2 Existing Conditions

  18. EPA and Home Depot Offer Tips to Conserve Water, Save Money

    EPA Pesticide Factsheets

    (PHILADELPHIA - March 16, 2015) Officials from the U.S. Environmental Protection Agency and The Home Depot kicked off Fix a Leak Week today at The Home Depot store in South Philadelphia by demonstrating several simple, inexpensive improvement

  19. Assessing the use of poplar tree systems as a landfill evapotranspiration barrier with the SHAW model.

    PubMed

    Preston, G M; McBride, R A

    2004-08-01

    The use of poplar tree systems (PTS) as evapotranspiration barriers on decommissioned landfills is gaining attention as an option for leachate management. This study involved field-testing the Simultaneous Heat and Water (SHAW) model for its ability to reliably estimate poplar transpiration, volumetric soil water content, and soil temperature at a landfill located in southern Ontario, Canada. The model was then used to estimate deep drainage and to ascertain the influence of a young PTS on the soil water balance of the landfill cover. The SHAW model tended to underestimate poplar transpiration [mean difference (MD) ranged from 0.33 to 3.55 mm on a daily total basis] and overestimate volumetric soil water content by up to 0.10 m3 m(-3). The model estimated soil temperature very well, particularly in the upper 1 m of the landfill cover (MD ranged from -0.1 to 1.6 x degrees C in this layer). The SHAW model simulations showed that deep drainage decreased appreciably with the presence of a young PTS largely through increased interception of rainfall, and that PTS have a good potential to act as effective evapotranspiration barriers in northern temperate climate zones.

  20. DEPOT: A Database of Environmental Parameters, Organizations and Tools

    SciTech Connect

    CARSON,SUSAN D.; HUNTER,REGINA LEE; MALCZYNSKI,LEONARD A.; POHL,PHILLIP I.; QUINTANA,ENRICO; SOUZA,CAROLINE A.; HIGLEY,KATHRYN; MURPHIE,WILLIAM

    2000-12-19

    The Database of Environmental Parameters, Organizations, and Tools (DEPOT) has been developed by the Department of Energy (DOE) as a central warehouse for access to data essential for environmental risk assessment analyses. Initial efforts have concentrated on groundwater and vadose zone transport data and bioaccumulation factors. DEPOT seeks to provide a source of referenced data that, wherever possible, includes the level of uncertainty associated with these parameters. Based on the amount of data available for a particular parameter, uncertainty is expressed as a standard deviation or a distribution function. DEPOT also provides DOE site-specific performance assessment data, pathway-specific transport data, and links to environmental regulations, disposal site waste acceptance criteria, other environmental parameter databases, and environmental risk assessment models.

  1. NASA Shuttle Logistics Depot (NSLD) - The application of ATE

    NASA Technical Reports Server (NTRS)

    Simpkins, Lorenz G.; Jenkins, Henry C.; Mauceri, A. Jack

    1990-01-01

    The concept of the NASA Shuttle Logistics Depot (NSLD) developed for the Space Shuttle Orbiter Program is described. The function of the NSLD at Cape Canaveral is to perform the acceptance and diagnostic testing of the Shuttle's space-rated line-replaceable units and shop-replaceable units (SRUs). The NSLD includes a comprehensive electronic automatic test station, program development stations, and assorted manufacturing support equipment (including thermal and vibration test equipment, special test equipment, and a card SRU test system). The depot activities also include the establishment of the functions for manufacturing of mechanical parts, soldering, welding, painting, clean room operation, procurement, and subcontract management.

  2. Guidelines for establishing a donor human milk depot.

    PubMed

    Geraghty, Sheela R; List, Betsy A; Morrow, Georgia B

    2010-02-01

    Human milk is the preferred choice for infant feeding. When a sick or premature infant's own mother's milk is unavailable, donor human milk is becoming more widely used. Many potential milk donors do not live within close proximity to the 10 North American not-for-profit milk banks. Transporting milk via commercial carriers can be inconvenient and costly for recipient banks. A network of donor human milk depots is one practical way to increase the quantity of available donor human milk. This article provides guidelines and practical suggestions for establishing a donor human milk depot.

  3. Defense Depot Mechanicsburg Total Quality Management Implementation Plan

    DTIC Science & Technology

    1989-06-01

    B T I TLEE 5 . FUNDING NUMBERS Defense Depot Mechanicsburg Total Quality Management Implementation Plan 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME...Form 298 (Rev. 2-89) L296- 102 Acces.ion For NYI J ... I:: ted DEFENSE DEPOT MECHANICSBURG PENNSYLVANIAL--I By_ TOTAL QUALITY MANAGEMENT K_~ t buty-n...IMPLEMENTATION PLAN Avmail-t!Ilty Codes IvLl c 2Dd/or JUN 3 0 1989 iDizt Special PURPOSE The purpose of this Total Quality Management Implementation

  4. NASA Shuttle Logistics Depot (NSLD) - The application of ATE

    NASA Technical Reports Server (NTRS)

    Simpkins, Lorenz G.; Jenkins, Henry C.; Mauceri, A. Jack

    1990-01-01

    The concept of the NASA Shuttle Logistics Depot (NSLD) developed for the Space Shuttle Orbiter Program is described. The function of the NSLD at Cape Canaveral is to perform the acceptance and diagnostic testing of the Shuttle's space-rated line-replaceable units and shop-replaceable units (SRUs). The NSLD includes a comprehensive electronic automatic test station, program development stations, and assorted manufacturing support equipment (including thermal and vibration test equipment, special test equipment, and a card SRU test system). The depot activities also include the establishment of the functions for manufacturing of mechanical parts, soldering, welding, painting, clean room operation, procurement, and subcontract management.

  5. Energy engineering analysis program study report: Anniston Army Depot, Anniston, Alabama. Executive summary. Final report

    SciTech Connect

    1982-06-01

    This is a summary of the Energy Engineering Analysis performed for the Anniston Army Depot (ANAD) in Anniston, Alabama. It includes recommendations to be considered in the development of a Basewide Energy Plan, consisting of energy conservation projects and other recommendations for reduction of the installation`s 1985 source energy consumption. This summary presents data on: Historical and predicted energy consumption; Energy conservation procedures for distribution systems; Energy conservation procedures for buildings and processes; Utilization of energy monitoring and control systems (EMCS); Utilization of wood biomass and waste fuels; Cogeneration and Replacement Boilers. The conservation of energy in existing facilities can be accomplished in the following two ways: Reduce the basic system energy requirements and source energy use; Recover energy discharged from one user and utilize this waste energy for other purposes.

  6. Robert R. Shaw, MD: thoracic surgical hero, Afghanistan medical pioneer, champion for the patient, never a surgical society president.

    PubMed

    Urschel, Harold C; Urschel, Betsey Bradley

    2012-06-01

    Dr Robert R. Shaw arrived in Dallas to practice Thoracic Surgery in 1937, as John Alexander's 7th Thoracic Surgical Resident from Michigan University Medical Center. Dr Shaw's modus operandi was, "You can accomplish almost anything, if you don't care who gets the credit." He was a remarkable individual who cared the most about the patient and very little about getting credit for himself. From 1937 to 1970, Dr Shaw established one of the largest lung cancer surgical centers in the world in Dallas, Texas. It was larger than M.D. Anderson and Memorial Sloan-Kettering Hospitals put together regarding the surgical treatment of lung cancer patients. To accomplish this, he had the help of Dr Donald L. Paulson, who trained at the Mayo Clinic and served as Chief of Thoracic Surgery at Brook Army Hospital during the Second World War. Following the War, because of his love for Texas, he ended up as a partner of Dr Shaw in Dallas. Together, they pursued the development of this very large surgical lung cancer center. Dr Shaw and his wife Ruth went to Afghanistan with Medico multiple times to teach men modern cardiac and thoracic surgery. They also served as consultants on Medico's Ship of Hope in Africa. Dr Shaw initiated multiple new operations including: 1) resection of Pancoast's cancer of the lung after preoperative irradiation; 2) upper lobe of the lung bronchoplasty, reattaching (and saving) the lower lobe to prevent the "disabling" pneumonectomy; and 3) resections of pulmonary mucoid impaction of the lung in asthmatics. Because of his humility and giving "the credit to others," Dr Shaw was never President of a major medical or surgical association.

  7. Computer-aided acquisition and logistics support (CALS): Concept of Operations for Depot Maintenance

    SciTech Connect

    Bourgeois, N.C.; Greer, D.K.

    1993-04-01

    This CALS Concept of Operations for Depot Maintenance provides the foundation strategy and the near term tactical plan for CALS implementation in the depot maintenance environment. The user requirements enumerated and the overarching architecture outlined serve as the primary framework for implementation planning. The seamless integration of depot maintenance business processes and supporting information systems with the emerging global CALS environment will be critical to the efficient realization of depot user's information requirements, and as, such will be a fundamental theme in depot implementations.

  8. Identification of a new supraclavicular brown fat depot in mice

    USDA-ARS?s Scientific Manuscript database

    The rediscovery of brown adipose tissue (BAT) in healthy adult humans raises the possibility of utilizing BAT to combat obesity and its related metabolic disorders. Adult humans possess limited amounts of BAT with the most thermoactive depot located in the supraclavicular area of the neck. Understan...

  9. Development of a Lunar Consumables Storage and Distribution Depot

    NASA Technical Reports Server (NTRS)

    Mueller, Robert P.; Notardonato, William

    2004-01-01

    NASA is in the preliminary planning stages for a future lunar base as a response to President George W. Bush's recent announcement of a new sustained exploration program beyond low earth orbit. Kennedy Space Center engineers are supporting this program by utilizing experience in Spaceport system design and operations to help develop a Lunar Consumables Depot. This depot will store propellants, life support fluids, and other consumables either transported from Earth or manufactured from In Situ resources. The depot will distribute these consumables in an energy efficient manner to end users including spacecraft, habitation modules, and rovers. This paper addresses some of the changes to lunar base architecture design as a result of advances in knowledge of lunar resources over the past 35 years, as well as technology advances in the area of In Situ Resource Utilization and consumable storage and distribution. A general system level description of the depot will be presented, including overall design philosophy and high level requirements. Finally, specific subsystem technologies that have been or will be developed by KSC will be addressed. Examples of these technologies are automated umbilicals, cryogenic refrigerators, novel storage vessels, advanced heat switches and heat exchangers, and self healing gaskets and wires.

  10. Red River Depot Operations Center Design Simulation Analysis

    DTIC Science & Technology

    1993-07-01

    prcepallets) (pilfts) (second) in i (21) 99.8% 1.4 25.2 itdal Acaumulating Cnvyr (17) 1.2 palets 0.0 0.0 P&P/Stow Accumulating... dispensed early in the pickers’ 8-hour shift. Similarly, most material from outside the DOC arrives early in each work day. 48 Defense Depot Red River

  11. Examination of adipose depot-specific PRAR moieties

    USDA-ARS?s Scientific Manuscript database

    Molecular mechanisms of peroxisome proliferator activated receptors (PPARs) are being defined rapidly, as illustrated by the volume of papers published. Much of the research is directed towards a clinical end-point/application; however, the non-homogeneous nature of adipose depots in laboratory ani...

  12. Orbiting Depot and Reusable Lander for Lunar Transportation

    NASA Technical Reports Server (NTRS)

    Petro, Andrew

    2009-01-01

    A document describes a conceptual transportation system that would support exploratory visits by humans to locations dispersed across the surface of the Moon and provide transport of humans and cargo to sustain one or more permanent Lunar outpost. The system architecture reflects requirements to (1) minimize the amount of vehicle hardware that must be expended while maintaining high performance margins and (2) take advantage of emerging capabilities to produce propellants on the Moon while also enabling efficient operation using propellants transported from Earth. The system would include reusable single- stage lander spacecraft and a depot in a low orbit around the Moon. Each lander would have descent, landing, and ascent capabilities. A crew-taxi version of the lander would carry a pressurized crew module; a cargo version could carry a variety of cargo containers. The depot would serve as a facility for storage and for refueling with propellants delivered from Earth or propellants produced on the Moon. The depot could receive propellants and cargo sent from Earth on a variety of spacecraft. The depot could provide power and orbit maintenance for crew vehicles from Earth and could serve as a safe haven for lunar crews pending transport back to Earth.

  13. Total Quality Management Implementation Plan Defense Depot Memphis

    DTIC Science & Technology

    1989-07-01

    Total Quality Management Implementation...improvement goals, implementation strategy and milestones. 6’ SEP 291989 /; ELECTE i= E 14. SUBJECT TERMS 15. NUMBER OF PAGES TQM ( Total Quality Management ), Depot...changing work environment where change is the norm. We are talking about changes in attitudes and habits. Total Quality Management is not a

  14. Radiological Scoping Survey of the Scotia Depot Scotia, New York

    SciTech Connect

    E. N. Bailey

    2005-02-05

    At the request of the Defense Logistics Agency, the Oak Ridge Institute for Science and Education conducted radiological scoping surveys of the Scotia Depot during the period of September 24 through 27, 2007. The scoping survey included visual inspections and limited radiological surveys performed in accordance with area classification that included surface scans, total and removable activity measurements, and soil sampling.

  15. Training Needs Analysis for Bus Depot Managers at GSRTC

    ERIC Educational Resources Information Center

    Shah, Hardik; Gopal, Raj

    2012-01-01

    Purpose: With rapid industrialization and population growth in the urban and rural areas in India, the demand for public transport has risen sharply. In the fast changing scenario in the public transit sector, the role of a bus depot manager (DM) has also undergone substantial transformation. This paper aims to identify and gauge the…

  16. Training Needs Analysis for Bus Depot Managers at GSRTC

    ERIC Educational Resources Information Center

    Shah, Hardik; Gopal, Raj

    2012-01-01

    Purpose: With rapid industrialization and population growth in the urban and rural areas in India, the demand for public transport has risen sharply. In the fast changing scenario in the public transit sector, the role of a bus depot manager (DM) has also undergone substantial transformation. This paper aims to identify and gauge the…

  17. Preliminary assessment of the health and environmental impacts of transporting M55 rockets from Lexington-Blue Grass Depot activity, Anniston Army depot, and Umatilla depot activity to alternative disposal facilities

    SciTech Connect

    Carnes, S.A.; Breck, J.E.; Copenhaver, E.D.; Coleman, P.R.; Griffin, G.D.; Hillsman, E.L.; Holcomb, M.C.; Johnson, P.E.; Kornegay, F.C.; Peterson, B.E.

    1986-03-01

    This assessment discusses the potential health and environmental impacts of transporting M55 rockets filled with nerve agent GB or VX from various existing Army storage depots to alternative Army depots for disposal. The origin depots include Anniston Army Depot in Alabama, Lexington-Blue Grass Depot Activity in Kentucky, and Umatilla Depot Activity in Oregon. The destination depots include Pine Bluff Arsenal in Arkansas, Tooele Army Depot in Utah, and the facility on Johnston Island in the central Pacific Ocean. This assessment considers the possible impacts of normal transport operations and of two postulated accident scenarios on the air quality, ground and surface water, aquatic ecology, terrestrial ecology, human health, and cultural and socioeconomic resources of the various transport corridors involved. The impacts of these scenarios are assessed for truck, train, and air transport for each orgin-destination pair. The analysis considers three basic scenario during transport: (1) normal operations with no atmospheric release of nerve agent; (2) a minor agent spill (the contents of one rocket being released to the biosphere); and (3) a worst-case accident involving the release of a large, specified quantity of nerve agent to the biosphere. The extremely low probabilities of such accidents, which are reported elsewhere, are noted.

  18. Magnetic field effects on viscous fingering of a ferrofluid in a radial Hele Shaw cell

    NASA Astrophysics Data System (ADS)

    Herreman, Wietze; Molho, Pierre; Neveu, Sophie

    2005-03-01

    We have studied the effects of a magnetic field on viscous fingering when a ferrofluid is pushed in a more viscous liquid in a circular Hele-Shaw cell. The main effect of the magnetic field, as already known, is to stabilize interfaces parallel to the field and to destabilize interfaces normal to the field. Depending on the growth regime (quasi static, fingering, dendritic growth), which depends on parameters like the cell thickness and oil viscosity, the combination of field effect and anisotropy is analyzed through the various observed patterns.

  19. The Mozart effect: questions about the seminal findings of Rauscher, Shaw, and colleagues.

    PubMed

    Fudin, Robert; Lembessis, Elizabeth

    2004-04-01

    Seminal evidence for the Mozart effect was presented by Rauscher, Shaw, and colleagues in 1993 and 1994. A critical evaluation of their methodologies and interpretation of findings raises questions that must be answered before this evidence can be regarded as valid. We discuss issues such as their scoring of the Stanford-Binet Intelligence Scale, the experimental design used in their 1993 study, the validity of their 1993 IQ measure, the duration of the Mozart effect, their choice of experimental tasks in relation to predictions of the trion model of neural functioning, and the statistical analyses and interpretation of results in the 1993 and 1994 studies.

  20. Experimental investigation of the onset of instability in a radial Hele-Shaw cell.

    PubMed

    Martyushev, L M; Birzina, A I; Konovalov, M S; Sergeev, A P

    2009-12-01

    The initial stage of interface instability upon radial displacement of a fluid in a Hele-Shaw cell is investigated. An air-silicone oil system is analyzed. The critical radii of stability relative to long-wave perturbations are determined. It is found that, in the investigated range of parameters, instability most often begins by a translational mechanism. It is ascertained that in the overwhelming majority of cases the critical radii of instability are smaller than the values predicted by the linear stability theory and external effects make this difference even greater. The obtained results are discussed and compared with the existing theories.

  1. Inertially driven buckling and overturning of jets in a Hele-Shaw cell.

    PubMed

    Pesci, Adriana I; Porter, Martin A; Goldstein, Raymond E

    2003-11-01

    We study a fluid jet descending through stratified surroundings at low Reynolds number in Hele-Shaw flow. The jet buckles and overturns inside a conduit of entrained fluid which supports smooth or unstable traveling waves. A model of the recirculating flow within the conduit shows that buckling and waves arise from Kelvin-Helmholtz instabilities and quantitatively accounts for the main experimental observations. Beyond the onset of the instability, a damped, forced Burgers' equation obtained from corrections to Darcy's law for small Reynolds number governs the interface dynamics and supports singularities corresponding to the observed jet overturning and unstable waves.

  2. Instabilities of an immiscible reactive micellar interface in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Niroobakhsh, Zahra; Litman, Matthew; Belmonte, Andrew

    2016-11-01

    We present the case of a micellar reaction involving two immiscible fluids, which results in the growth of a thin viscoelastic layer between them. A Hele-Shaw cell is initially filled with different oils, including oleic acid, which acts as a cosurfactant. The oil is displaced by an aqueous solution of the surfactant cetylpyridinium chloride. A rich variety of viscous fingering patterns are observed, which are different from classic Saffman-Taylor patterns. We discuss how they change with concentration, surfactant injection rate and type of oil. We also measure the viscoelastic properties of this material using an interfacial rheometer.

  3. Simulations of water and heat exchanges for a subtropical mixed evergreen forest with BATS2 and SHAW

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Wu, B.; Li, M.

    2010-12-01

    In this study, the water and energy exchanges between land surface and atmosphere were simulated by BATS2 and SHAW for a subtropical mixed evergreen forest (the Lien-Hua-Chih site) with continuous measurements of hydrological and micrometeorological variables, and eddy covariance fluxes. The BATS2 (Dickinson et al. 1998) model is the second version of BATS (Biosphere-Atmosphere Transfer Scheme). The BATSs are typical land surface models frequently used by atmospheric research communities to study land surface processes. A bulk canopy layer (Big leaf assumption) is parameterized to control the water flux from the root zone to the atmosphere by a stomatal conductance model limited by soil moisture, CO¬2 concentration, and micrometeorological factors. The SHAW (Simultaneous Heat And Water; Flerchinger, 2000) model, originally developed to simulate soil freezing and thawing (Flerchinger and Saxton, 1989), can simultaneously simulate heat, water, and solute transfer within a layered system of plant canopy, snowpack, dead plant residue, soil frost, and underlying soil. The model can be applied to assess management and climate effects on various biological and hydrological processes. Although the original applications of BATS2 and SHAW are not quite the same, both models are capable of simulating water and energy exchanges between land surface and atmosphere. Root zone moisture contents computed by BATS2 and the corresponding layers of soil moistures by SHAW were compared with field measurements of soil moisture on daily to seasonal scales. The soil moisture responses of SHAW are more sensitive to atmospheric forcing than those of BATS2 due to layered descriptions of underlying soils. Similar results were found on descriptions of soil temperatures. On the contrary, BATS2 is superior to SHAW on describing latent and sensible heat fluxes variations on the daily scales due to the sophisticated stomatal conductance model. However, the differences of surface fluxes on the

  4. Adipose depots differ in cellularity, adipokines produced, gene expression, and cell systems

    PubMed Central

    Dodson, Michael V; Du, Min; Wang, Songbo; Bergen, Werner G; Fernyhough-Culver, Melinda; Basu, Urmila; Poulos, Sylvia P; Hausman, Gary J

    2014-01-01

    The race to manage the health concerns related to excess fat deposition has spawned a proliferation of clinical and basic research efforts to understand variables including dietary uptake, metabolism, and lipid deposition by adipocytes. A full appreciation of these variables must also include a depot-specific understanding of content and location in order to elucidate mechanisms governing cellular development and regulation of fat deposition. Because adipose tissue depots contain various cell types, differences in the cellularity among and within adipose depots are presently being documented to ascertain functional differences. This has led to the possibility of there being, within any one adipose depot, cellular distinctions that essentially result in adipose depots within depots. The papers comprising this issue will underscore numerous differences in cellularity (development, histogenesis, growth, metabolic function, regulation) of different adipose depots. Such information is useful in deciphering adipose depot involvement both in normal physiology and in pathology. Obesity, diabetes, metabolic syndrome, carcass composition of meat animals, performance of elite athletes, physiology/pathophysiology of aging, and numerous other diseases might be altered with a greater understanding of adipose depots and the cells that comprise them—including stem cells—during initial development and subsequent periods of normal/abnormal growth into senescence. Once thought to be dormant and innocuous, the adipocyte is emerging as a dynamic and influential cell and research will continue to identify complex physiologic regulation of processes involved in adipose depot physiology. PMID:26317047

  5. Deterministic models for Laplacian growth of thin fingers in a Hele-Shaw geometry

    NASA Astrophysics Data System (ADS)

    Pecelerowicz, Michał; Szymczak, Piotr

    2014-05-01

    Laplacian growth is one of the fundamental mechanisms of pattern formation, driving such natural processes like electrodeposition, dielectric breakdown or viscous fingering. The characteristic features of these processes include a strong competition between spontaneously formed dendrite-like structures, and tip-splitting effects when dendrites bifurcate into secondary branches. Following Carleson and Makarov [1] we consider a simple, deterministic model of Laplacian growth, in which the growth takes place only at the tips of the long-and-thin fingers. The dynamics of the system can then be described by a deterministic Loewner equation. However, in contrast to [1], we allow the fingers to split, which is crucial to obtain the patterns corresponding to those observed in nature. We discuss different splitting criterions and study the dynamics of the model in variety of geometries including half-plane, channel, radial and the Hele-Shaw geometry. The latter is particularly relevant experimentally. In the Hele-Shaw cell, the pressure difference is imposed at two opposite ends of the system, whereas the two other boundaries are assumed to be reflecting. We derive the Loewner equation for this geometry (expressed in terms of elliptic functions) and study the tip-splitting dynamics in such a setting. In particular, we analyze in detail the tip-splitting cascade, triggered as the fingers approach the edge of the system. [1] L. Carleson and N. Makarov, J. Anal. Math. 87, 103 (2002).

  6. Spiral pattern in a radial displacement in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Ban, Mitsumasa; Nagatsu, Yuichiro; Hayashi, Atsushi; Kato, Yoshihiro; Tada, Yutaka

    2008-11-01

    When a reactive and miscible less-viscous liquid displaces a more-viscous liquid in a Hele-Shaw cell, reactive miscible viscous fingering takes place. We have experimentally shown that the pattern created by the displacement of a more-viscous fluid by a less-viscous one in a radial Hele-Shaw cell develops not radially but spirally when a more-viscous sodium polyacrylate solution is displaced by a less-viscous trivalent iron ion (Fe^3+) solution with a sufficiently high concentration of Fe^3+. Another experiment in order to investigate the mechanism of spiral pattern formation revealed that an instantaneous chemical reaction takes place between the two fluids and at high Fe^3+ concentrations it produces a film of the gel at the contact plane. The gel is formed by three-dimensional network structures between the polyacrylate solution and the trivalent iron ion (Fe^3+) solution. We have proposed a physical model that the gel's film is responsible for the form of the spiral pattern.

  7. Fundamental investigation of foam flow in a liquid-filled Hele-Shaw cell.

    PubMed

    Osei-Bonsu, Kofi; Shokri, Nima; Grassia, Paul

    2016-01-15

    The relative immobility of foam in porous media suppresses the formation of fingers during oil displacement leading to a more stable displacement which is desired in various processes such as Enhanced Oil Recovery (EOR) or soil remediation practices. Various parameters may influence the efficiency of foam-assisted oil displacement such as properties of oil, the permeability and heterogeneity of the porous medium and physical and chemical characteristics of foam. In the present work, we have conducted a comprehensive series of experiments using customised Hele-Shaw cells filled with either water or oil to describe the effects of foam quality, permeability of the cell as well as the injection rate on the apparent viscosity of foam which is required to investigate foam displacement. Our results reveal the significant impact of foam texture and bubble size on the foam apparent viscosity. Foams with smaller bubble sizes have a higher apparent viscosity. This statement only applies (strictly speaking) when the foam quality is constant. However, wet foams with smaller bubbles may have lower apparent viscosity compared to dry foams with larger bubbles. Furthermore, our results show the occurrence of more stable foam-water fronts as foam quality decreases. Besides, the complexity of oil displacement by foam as well as its destabilizing effects on foam displacement has been discussed. Our results extend the physical understanding of foam-assisted liquid displacement in Hele-Shaw cell which is a step towards understanding the foam flow behaviour in more complex systems such as porous media.

  8. Failure to confirm the Rauscher and Shaw description of recovery of the Mozart effect.

    PubMed

    Steele, K M; Brown, J D; Stoecker, J A

    1999-06-01

    The Mozart effect is an increase in spatial reasoning scores detected immediately after listening to the first movement of a Mozart piano sonata. Rauscher and Shaw (1998) suggested that failure to produce a Mozart effect could arise from carryover effects of a spatial reasoning pretest which may interfere with the effect of listening to Mozart. They cited an unpublished study in which a verbal distractor was inserted between the pretest and listening condition, and the manipulation produced the recovery of a Mozart effect. This experiment attempted to confirm the unpublished study. 206 college students were exposed to one of three sequences, pretest-Verbal distractor material-Mozart, pretest-Mozart-Verbal distractor material, and pretest-Verbal distractor material. An immediate posttest indicated no significant difference on solution of paper folding and cutting items among the three groups. The results do not support Rauscher and Shaw (1998). Our negative results are consistent with prior failures in other laboratories to produce a Mozart effect.

  9. Buoyancy-driven instability of a miscible horizontal displacement in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Haudin, F.; Riolfo, L. A.; Knaepen, B.; de Wit, A.

    2012-11-01

    In Hele-Shaw cells, viscous fingers are forming when a fluid is injected into a more viscous one. If the two fluids are reversed, with the less mobile fluid injected into the low viscosity one, the situation is expected to be stable from a viscous point of view. Nevertheless, a destabilization of the interface can be observed due to a buoyancy-driven effect if a density difference exists between the two miscible fluids. As a result, the Poiseuille profile established in the gap of the cell locally destabilizes and convection rolls are forming. In a view from above, a striped pattern is observed at the miscible interface between the two fluids. To characterize the development of this instability, we have performed an experimental study of viscously stable miscible displacements in a Hele-Shaw cell with radial injection. The displacing fluids are aqueous solutions of glycerol and the displaced ones are either dyed water or dyed glycerol solutions. The way the relative properties of the two fluids is influencing the onset time of the instability and the characteristic size of the pattern is studied. The influence of the gap width and of the flow rate on the buoyantly unstable dynamics is also characterized.

  10. Foam morphology, frustration and topological defects in a Negatively curved Hele-Shaw geometry

    NASA Astrophysics Data System (ADS)

    Mughal, Adil; Schroeder-Turk, Gerd; Evans, Myfanwy

    2014-03-01

    We present preliminary simulations of foams and single bubbles confined in a narrow gap between parallel surfaces. Unlike previous work, in which the bounding surfaces are flat (the so called Hele-Shaw geometry), we consider surfaces with non-vanishing Gaussian curvature. We demonstrate that the curvature of the bounding surfaces induce a geometric frustration in the preferred order of the foam. This frustration can be relieved by the introduction of topological defects (disclinations, dislocations and complex scar arrangements). We give a detailed analysis of these defects for foams confined in curved Hele-Shaw cells and compare our results with exotic honeycombs, built by bees on surfaces of varying Gaussian curvature. Our simulations, while encompassing surfaces of constant Gaussian curvature (such as the sphere and the cylinder), focus on surfaces with negative Gaussian curvature and in particular triply periodic minimal surfaces (such as the Schwarz P-surface and the Schoen's Gyroid surface). We use the results from a sphere-packing algorithm to generate a Voronoi partition that forms the basis of a Surface Evolver simulation, which yields a realistic foam morphology.

  11. Contracting bubbles in Hele-Shaw cells with a power-law fluid

    NASA Astrophysics Data System (ADS)

    McCue, Scott W.; King, John R.

    2011-02-01

    The problem of bubble contraction in a Hele-Shaw cell is studied for the case in which the surrounding fluid is of power-law type. A small perturbation of the radially symmetric problem is first considered, focussing on the behaviour just before the bubble vanishes, it being found that for shear-thinning fluids the radially symmetric solution is stable, while for shear-thickening fluids the aspect ratio of the bubble boundary increases. The borderline (Newtonian) case considered previously is neutrally stable, the bubble boundary becoming elliptic in shape with the eccentricity of the ellipse depending on the initial data. Further light is shed on the bubble contraction problem by considering a long thin Hele-Shaw cell: for early times the leading-order behaviour is one-dimensional in this limit; however, as the bubble contracts its evolution is ultimately determined by the solution of a Wiener-Hopf problem, the transition between the long thin limit and the extinction limit in which the bubble vanishes being described by what is in effect a similarity solution of the second kind. This same solution describes the generic (slit-like) extinction behaviour for shear-thickening fluids, the interface profiles that generalize the ellipses that characterize the Newtonian case being constructed by the Wiener-Hopf calculation.

  12. Coriolis effects on rotating Hele-Shaw flows: a conformal-mapping approach.

    PubMed

    Miranda, José A; Gadêlha, Hermes; Dorsey, Alan T

    2010-12-01

    The zero surface tension fluid-fluid interface dynamics in a radial Hele-Shaw cell driven by both injection and rotation is studied by a conformal-mapping approach. The situation in which one of the fluids is inviscid and has negligible density is analyzed. When Coriolis force effects are ignored, exact solutions of the zero surface tension rotating Hele-Shaw problem with injection reveal suppression of cusp singularities for sufficiently high rotation rates. We study how the Coriolis force affects the time-dependent solutions of the problem, and the development of finite time singularities. By employing Richardson's harmonic moments approach we obtain conformal maps which describe the time evolution of the fluid boundary. Our results demonstrate that the inertial Coriolis contribution plays an important role in determining the time for cusp formation. Moreover, it introduces a phase drift that makes the evolving patterns rotate. The Coriolis force acts against centrifugal effects, promoting (inhibiting) cusp breakdown if the more viscous and dense fluid lies outside (inside) the interface. Despite the presence of Coriolis effects, the occurrence of finger bending events has not been detected in the exact solutions.

  13. Master Environmental Plan: Fort Wingate Depot Activity, Gallup, New Mexico

    SciTech Connect

    Biang, C.A.; Yuen, C.R.; Biang, R.P.; Antonopoulos, A.A.; Ditmars, J.D.

    1990-12-01

    The master environmental plan is based on an environmental assessment of the areas requiring environmental evaluation (AREEs) at Fort Wingate Depot Activity near Gallup, New Mexico. The Fort Wingate Depot Activity is slated for closure under the Base Closure and Realignment Act, Public Law 100--526. The MEP assesses the current status, describes additional data requirements, recommends actions for the sites, and establishes a priority order for actions. The plan was developed so that actions comply with hazardous waste and water quality regulations of the State of New Mexico and applicable federal regulations. It contains a brief history of the site, relevant geological and hydrological information, and a description of the current status for each AREE along with a discussion of the available site-specific data that pertain to existing or potential contamination and the impact on the environment. 35 refs., 27 figs., 23 tabs.

  14. [Treatment of bradycardiac arrhythmias with depot-orciprenaline (author's transl)].

    PubMed

    So, C S; Volger, E

    1976-07-02

    24 patients with bradycardiac arrhythmias of various origin were treated with a new depot preparation of orciprenaline. The special galenical preparation guarantees effectiveness ofr 8-10 hours. In 21 patients (87%), therefore, one dragee morning and evening was sufficient to obtain a mean rise in frequency of 57%. The preparation had to be discontinued in 3 cases because of side effects such as increase in ventricular extrasystoles, anginal complaints and critical rise of blood pressure in hypertension. Because of its trouble-free administration in a depot form the preparation not only offers a practical advantage over the short-acting commercial preparations, but also shows a reliable efficacy. It can therefore be given under regular supervision in all forms of bradycardiac arrhythmias with stable ventricular frequency and satisfactory cardiac output.

  15. KC-46 Workforce Requirements for Depot Maintenance Activation

    DTIC Science & Technology

    2014-03-27

    Community College of the Air force CFR: Code of Federal Regulation CLS: Contract Logistic Service CoF: Complex of the Future CSR : Case Study...subject. Therefore, the method of choice for this research study is to seek expert opinion from those in the field of aircraft maintenance, gather...training to ensure airmen become experts in their field . However, personnel at the depot do not move around, in fact they may stay their whole

  16. [Influence of ACTH-depot doses on neuroendocrine gestosis treatment].

    PubMed

    Klimek, Marek; Tomaszewska, Beata

    2006-02-01

    Two dosing methods of ACTH-depot therapy were compared dependently on gestational age and sequence of applied injections. It has been concluded that better efficacy was observed in single doses method comparing to serial doses in 2nd trimester. Retrospectively, 380 pregnancies were analyzed, in which ACTH-depot therapy was applied using 0,5 mg doses. In 140 subjects (Group I, 1990-1991) 3 injection series every 2nd day with additional antibiotic (i.e. Monural 3g) were administrated. In the rest 240 (Group II, 1997-2002) single doses were applied during the whole period of pregnancy due to recurrent vomiting or decreased CAP1 serum levels under 0,8 micromol/l/min and CAP2 under 1,4 micromol/l/min in 1st trimester and compulsory in ACTH serum levels under 5,0 pg/ml. Clinical results can be compared with oxytocinase and ACTH serum levels, what allows to understand enzymatic control of internal maternal state. Role of ACTH not only in lung maturation, but also in onset of labor was proved in the mechanism of influence on immunologic tolerance. In hormonal threatening pregnancies enzymatic component is less helpful in predicting birth date because of common irregular oxitocinase pattern in such patients. On the other hand constant enzymatic increase proves effectiveness of ACTH-depot therapy in neurendocrine-gestoses, or in insulin-requiring pregnant patients. Acquired results of neonatal state proved that: 1. in pregnancies after infertility treatment early application of substitutional hormonotherapy wsith single doses of 0,5 mg ACTH-depot in early gestational weeks is more efficient method of ACTH dosing than 3 injections method in 2nd trimester 2. serum prelabour oxitocinase levels were precise factors of clinical results.

  17. [Treatment of Adult Schizophrenic Patients With Depot Antipsychotics].

    PubMed

    Jaramillo González, Luis Eduardo; Gómez Restrepo, Carlos; García Valencia, Jenny; de la Hoz Bradford, Ana María; Ávila-Guerra, Mauricio; Bohórquez Peñaranda, Adriana

    2014-01-01

    To determine the indications of long-acting antipsychotic injection and what its effectiveness and safety in adult patients with schizophrenia during the treatment maintenance phase. A clinical practice guideline was elaborated under the parameters of the Methodological Guide of the Ministerio de Salud y Protección Social to identify, synthesize and evaluate the evidence and make recommendations about the treatment and follow-up of adult patients with schizophrenia. The evidence of NICE guide 82 was adopted and updated. The evidence was presented to the Guideline Developing Group and recommendations, employing the GRADE system, were produced. The literature review shows that the evidence has moderate to low quality. 8 articles were used. The risk of relapse was lower with depot risperidone and paliperidone palmitate when compared with placebo. For the risk of hospitalizations comparing depot antipsychotics (APD) versus oral AP, the result is inconclusive. Globally the second-generation APD had a lower risk of discontinuation when compared with placebo. The second generation AP had higher risk of extrapyramidal syndromes than placebo, as in the use of antiparkinsonian. The comparison of second-generation AP injections versus placebo showed an increased risk of early weight gain. The use of depot antipsychotics in the maintenance phase of adult patients diagnosed with schizophrenia is recommended if there is no adherence to oral antipsychotics as the patient's preference. It is not recommended depot antipsychotics in the acute phase of schizophrenia in adults. Copyright © 2014 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  18. Life-cycle analysis of depot versus rehabilitation manual wheelchairs.

    PubMed

    Cooper, R A; Robertson, R N; Lawrence, B; Heil, T; Albright, S J; VanSickle, D P; Gonzalez, J

    1996-02-01

    The proper selection of a wheelchair requires making several critical decisions, not the least of which is what type of wheelchair is appropriate. The International Organization for Standards (ISO) continues to develop and refine wheelchair standards. Standards allow the objective comparison of products from various sources, permitting consumers or clinicians to assess wheelchairs with which they are not familiar by comparing test results. This study consisted of three components: 1) the comparison of fatigue test results with a planar ANSI/RESNA test dummy to a HERL contoured test dummy; 2) the comparison of fatigue test results for common depot versus common rehabilitation manual wheelchairs; and 3) the comparison of fatigue test results for manual rehabilitation wheelchairs with solid 8-inch casters versus those with pneumatic 8-inch casters. Rehabilitation wheelchairs lasted on average 13.2 times longer than the depot wheelchairs. Both types, tested with the standard ISO-ANSI/RESNA dummy, lasted on average 2.1 times longer than those wheelchairs tested using the contoured dummy. The three rehabilitation wheelchairs equipped with 8-inch pneumatic casters lasted on average 3.2 times longer than the 6 rehabilitation wheelchairs equipped with solid 8-inch casters. The depot wheelchairs cost about 3.4 times as much to operate per cycle or per meter than the rehabilitation wheelchairs. The rehabilitation wheelchairs tended to experience component failures, while the depot wheelchairs tended to experience frame failures. Our testing indicates that the tests in the ISO-ANSI/RESNA standards can relate design features to fatigue test results and durability. Rehabilitation wheelchairs tend to use higher quality materials and better manufacturing practices, and they provide greater mobility for wheelchair users. Purchasers and prescribers of wheelchairs should consider the life-cycle cost and not just the purchase price for wheelchairs.

  19. Radiological survey of Seneca Army Depot. Final report

    SciTech Connect

    Morrissey, J.A.; Maloney, J.C.

    1986-01-01

    A radiological survey was conducted by the U.S. Army RADCON Team on a row of 11 ammunition storage bunkers located at Seneca Army Depot, Romulus, NY. These bunkers had been utilized for the storage of uranium ore (pitchblende) during the Manhattan Project. Low levels of radioactive contamination were measured in and about the structures with radiac instruments, and supporting laboratory measurements were made of air, water, and soil radioactive concentrations. These data were used to plan and execute appropriate site measures.

  20. The Home Depot Upgrades its Corporate Building Prototype

    SciTech Connect

    none,

    2013-03-01

    The Home Depot partnered with the Department of Energy (DOE) to develop and implement solutions to build new, low-energy buildings that are at least 50% below Standard 90.1-2007 of the American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE), the American National Standards Institute (ANSI), and the Illuminating Engineering Society of North America (IESNA) as part of DOE’s Commercial Building Partnerships (CBP) Program.

  1. Developing a safe on-orbit cryogenic depot

    NASA Astrophysics Data System (ADS)

    Bahr, Nicholas J.

    1992-09-01

    New U.S. space initiatives will require technology to realize planned programs such as piloted lunar and Mars missions. Key to the optimal execution of such missions are high performance orbit transfer vehicles and propellant storage facilities. Large amounts of liquid hydrogen and oxygen demand a uniquely designed on-orbit cryogenic propellant depot. Because of the inherent dangers in propellant storage and handling, a comprehensive system safety program must be established. This paper shows how the myriad and complex hazards demonstrate the need for an integrated safety effort to be applied from program conception through operational use. Even though the cryogenic depot is still in the conceptual stage, many of the hazards have been identified, including fatigue due to heavy thermal loading from environmental and operating temperature extremes, micrometeoroid and/or depot ancillary equipment impact (this is an important problem due to the large surface area needed to house the large quantities of propellant), docking and maintenance hazards, and hazards associated with extended extravehicular activity. Various safety analysis techniques were presented for each program phase. Specific system safety implementation steps were also listed. Enhanced risk assessment was demonstrated through the incorporation of these methods.

  2. Regional optimization model for locating supplemental recycling depots.

    PubMed

    Lin, Hung-Yueh; Chen, Guan-Hwa

    2009-05-01

    In Taiwan, vendors and businesses that sell products belonging to six classes of recyclable materials are required to provide recycling containers at their local retail stores. The integration of these private sector facilities with the recycling depots established by local authorities has the potential to significantly improve residential access to the recycling process. An optimization model is accordingly developed in this work to assist local authorities with the identification of regions that require additional recycling depots for better access and integration with private facilities. Spatial accessibility, population loading and integration efficiency indicators are applied to evaluate whether or not a geographic region is in need of new recycling depots. The program developed here uses a novel algorithm to obtain the optimal solution by a complete enumeration of all cells making up the study area. A case study of a region in Central Taiwan is presented to demonstrate the use of the proposed model and the three indicators. The case study identifies regions without recycling points, prioritizes them based on population density, and considers the option of establishing recycling centers that are able to collect multiple classes of recycling materials. The model is able to generate information suitable for the consideration of decision-makers charged with prioritizing the installation of new recycling facilities.

  3. Developing a safe on-orbit cryogenic depot

    NASA Technical Reports Server (NTRS)

    Bahr, Nicholas J.

    1992-01-01

    New U.S. space initiatives will require technology to realize planned programs such as piloted lunar and Mars missions. Key to the optimal execution of such missions are high performance orbit transfer vehicles and propellant storage facilities. Large amounts of liquid hydrogen and oxygen demand a uniquely designed on-orbit cryogenic propellant depot. Because of the inherent dangers in propellant storage and handling, a comprehensive system safety program must be established. This paper shows how the myriad and complex hazards demonstrate the need for an integrated safety effort to be applied from program conception through operational use. Even though the cryogenic depot is still in the conceptual stage, many of the hazards have been identified, including fatigue due to heavy thermal loading from environmental and operating temperature extremes, micrometeoroid and/or depot ancillary equipment impact (this is an important problem due to the large surface area needed to house the large quantities of propellant), docking and maintenance hazards, and hazards associated with extended extravehicular activity. Various safety analysis techniques were presented for each program phase. Specific system safety implementation steps were also listed. Enhanced risk assessment was demonstrated through the incorporation of these methods.

  4. Fundamental understanding of drug absorption from a parenteral oil depot.

    PubMed

    Kalicharan, Raween W; Schot, Peter; Vromans, Herman

    2016-02-15

    Oil depots are parenteral drug formulations meant for sustained release of lipophilic compounds. Until now, a comprehensive understanding of the mechanism of drug absorption from oil depots is lacking. The aim of this paper was to fill this gap. A clinical study with healthy volunteers was conducted. An oil depot with nandrolone decanoate and benzyl alcohol was subcutaneously administered in the upper arm of female volunteers. Pharmacokinetic profiles of both substances were related to each other and to literature data. Benzyl alcohol absorbs much more rapidly than nandrolone. In detail, it appears that benzyl alcohol enters the central compartment directly, while nandrolone decanoate is recovered in serum after a lag time. This lag time is also seen in literature data, although not reported explicitly. The absorption of nandrolone is enhanced by the presence of benzyl alcohol. This is most likely an effect of altered oil viscosity and partition coefficient between the oil and aqueous phase. The absorption rate constant of compounds is found to be related to the logP of the solubilized prodrug. The absorption rate is however not only determined by the physico-chemical properties of the formulation but also by the tissue properties. Here, it is argued that lymphatic flow must be considered as a relevant parameter.

  5. The contribution of the in-vivo fate of an oil depot to drug absorption.

    PubMed

    Kalicharan, R W; Oussoren, C; Schot, P; de Rijk, E; Vromans, H

    2017-08-07

    Sustained release of lipophilic compounds can be achieved with oil depots. These parenteral formulations are generally injected in the vastus lateralis and deltoid muscle. It is known that the absorption rate differs between these two muscles. The reason for this is not fully understood. The aim of the current study was to investigate the fate of an oil depot in different tissues to elucidate whether the disappearance rate of oil is the cause of observed differences in absorption rate. A study with healthy volunteers was conducted to determine 1.0mL oil depots in the vastus lateralis and deltoid muscle for two weeks. The spatial distribution of the oil depots was determined using MRI. Additionally, a study in rats was conducted to microscopically examine the oil immediately and after 31days of injection. All rats were injected with a 0.1mL oil depot with and without benzyl alcohol (BOH), a commonly used excipient in oil depots. In humans, it was shown that all oil depots were equal in volume and surface area directly after injection. Moreover, the disappearance rate for all oil depots was similar; within one week there was no depot visible anymore by MRI. This in contrast to the depots in rats, which were still microscopically visible after 31days. It is concluded from these observations that the oil is dispersed to small droplets in the course of time. The resulting increase in surface area does not lead to an increase in absorption rate however. The results of this paper show that the variation in drug absorption as found for the two muscles is not caused by a distinction in surface areas or disappearance rates of the oil depots. Therefore, it is argued that the local tissue drainage (e.g. lymph flow) plays a considerable role in drug absorption from oil depots, whereby the lymph flow differs between the muscles. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Marching toward Justice: Lessons Learned from the Shaw High School Mighty Cardinals Marching Band in East Cleveland

    ERIC Educational Resources Information Center

    Luminais, Misty; Williams, Rhonda Y.

    2016-01-01

    The Shaw High School marching band has emerged as a collective site of individual and group pride and empowerment in the stories gathered through the community-based "Voicing & Action Project", which the Social Justice Institute debuted in East Cleveland. At first glance, a high school marching band might not have much in common with…

  7. Marching toward Justice: Lessons Learned from the Shaw High School Mighty Cardinals Marching Band in East Cleveland

    ERIC Educational Resources Information Center

    Luminais, Misty; Williams, Rhonda Y.

    2016-01-01

    The Shaw High School marching band has emerged as a collective site of individual and group pride and empowerment in the stories gathered through the community-based "Voicing & Action Project", which the Social Justice Institute debuted in East Cleveland. At first glance, a high school marching band might not have much in common with…

  8. A Comprehensive Program for the Training of Elementary School Teachers at Shaw University. Final Report, Part I.

    ERIC Educational Resources Information Center

    Shaw Univ., Raleigh, NC.

    This report contains a description of the current elementary teacher education program at Shaw University; a brief summary of each of the nine U.S. Office of Education models for elementary teacher education programs; review and synthesis of concepts in the three models (Florida State, Georgia, and Massachusetts) most applicable in redeveloping…

  9. Analytic theory for the determination of velocity and stability of bubbles in a Hele-Shaw cell. Part 2: Stability

    NASA Technical Reports Server (NTRS)

    Tanveer, Saleh

    1989-01-01

    The analysis is extended to determine the linear stability of a bubble in a Hele-Shaw cell analytically. Only the solution branch corresponding to largest possible bubble velocity U for given surface tension is found to be stable, while all the others are unstable, in accordance with earlier numerical results.

  10. Wavelength selection in injection-driven Hele-Shaw flows: A maximum amplitude criterion

    NASA Astrophysics Data System (ADS)

    Dias, Eduardo; Miranda, Jose

    2013-11-01

    As in most interfacial flow problems, the standard theoretical procedure to establish wavelength selection in the viscous fingering instability is to maximize the linear growth rate. However, there are important discrepancies between previous theoretical predictions and existing experimental data. In this work we perform a linear stability analysis of the radial Hele-Shaw flow system that takes into account the combined action of viscous normal stresses and wetting effects. Most importantly, we introduce an alternative selection criterion for which the selected wavelength is determined by the maximum of the interfacial perturbation amplitude. The effectiveness of such a criterion is substantiated by the significantly improved agreement between theory and experiments. We thank CNPq (Brazilian Sponsor) for financial support.

  11. Universality Results for Multi-Layer Hele-Shaw and Porous Media Flows

    NASA Astrophysics Data System (ADS)

    Daripa, Prabir

    2012-11-01

    Saffman-Taylor instability is a well known viscosity driven instability of an interface. Motivated by a need to understand the effect of various injection policies currently in practice for chemical enhanced oil recovery, we study linear stability of displacement processes in a Hele-Shaw cell involving injection of an arbitrary number of immiscible fluid phases in succession. This is a problem involving many interfaces. Universal stability results have been obtained for this multi-layer (multi-region) flow in the sense that the results hold with arbitrary number of interfaces. These stability results have been applied to design injection policies that are considerably less unstable than the pure Saffman-Taylor case. In particular, we determine specific values of the viscosity of the fluid layers corresponding to smallest unstable band. Moreover, we discuss universal selection principle of optimal viscous profiles. The talk is based on following papers. Qatar National Fund (a member of the Qatar Foundation).

  12. Fingering of exothermic reaction-diffusion fronts in Hele-Shaw cells with conducting walls.

    PubMed

    D'Hernoncourt, J; Kalliadasis, S; De Wit, A

    2005-12-15

    We consider the influence of heat losses through the walls of a Hele-Shaw cell on the linear stability and nonlinear dynamics of exothermic chemical fronts whose solutal and thermal contributions to density changes have the same signs. Our analysis is based on the reaction-diffusion-convection equations obtained from the Darcy-Boussinesq approximation. The parameters governing the equations are the Damkohler number, a kinetic parameter d, the Lewis number Le, the thermal-expansion coefficient gammaT, and a heat-transfer coefficient alpha which measures heat losses through the walls. We show that for thermally insulating walls, the temperature profile is a front that follows the concentration profile, while in the presence of heat losses, the temperature profile becomes a pulse that leads to a nonmonotonic density profile which in turn may lead to a destabilization of an otherwise stable front.

  13. Swimming Pattern of Vorticella convallaria Trophont in the Hele-Shaw Confinements

    NASA Astrophysics Data System (ADS)

    Sotelo, Luz; Davidson, John; Park, Young-Gil; Jung, Sunghwan; Ryu, Sangjin

    2015-11-01

    In the trophont form Vorticella convallariais a sessile stalked ciliate, which consists of an inverted bell-shaped cell body (zooid) and a slender stalk attaching the zooid to a substrate. Under mechanical shearing, the zooid is separated from the stalk and can swim using circular cilia rows around the oral part. Here we present how the stalkless trophont zooid of V. convallariaswims in Hele-Shaw geometries, as a model system for microorganism swimming. After having harvested stalkless zooids, we observed their swimming in water between two glass surfaces with narrow gaps using video microscopy. Based on their swimming trajectories measured with image analysis, we investigated how the swimming pattern of the trophont zooid of V. convallaria was influenced by the constraints. Supported by Nebraska EPSCoR First Award Grant for SR and UTPA URI Award for YP.

  14. Ferrofluid patterns in Hele-Shaw cells: Exact, stable, stationary shape solutions

    NASA Astrophysics Data System (ADS)

    Lira, Sérgio A.; Miranda, José A.

    2016-01-01

    We investigate a quasi-two-dimensional system composed of an initially circular ferrofluid droplet surrounded by a nonmagnetic fluid of higher density. These immiscible fluids flow in a rotating Hele-Shaw cell, under the influence of an in-plane radial magnetic field. We focus on the situation in which destabilizing bulk magnetic field effects are balanced by stabilizing centrifugal forces. In this framing, we consider the interplay of capillary and magnetic normal traction effects in determining the fluid-fluid interface morphology. By employing a vortex-sheet formalism, we have been able to find a family of exact stationary N -fold polygonal shape solutions for the interface. A weakly nonlinear theory is then used to verify that such exact interfacial solutions are in fact stable.

  15. Radial Hele-Shaw flow with suction: Fully nonlinear pattern formation

    NASA Astrophysics Data System (ADS)

    Chen, Ching-Yao; Huang, Yu-Sheng; Miranda, José A.

    2014-05-01

    We study the development of intricate, fully nonlinear immiscible interfacial patterns in the suction-driven radial Hele-Shaw problem. The complex-shaped, contracting fluid-fluid interface arises when an initially circular blob of more viscous fluid, surrounded by less viscous one, is drawn into an eccentric point sink. We present sophisticated numerical simulations, based on a diffuse interface model, that capture the most prominent interfacial features revealed by existing experimental studies of the problem. The response of the system to changes in the capillary number is investigated, accurately revealing the occurrence of finger competition phenomena, and correctly describing the velocity behavior of both inward- and outward-pointing fingers. For the large-capillary-number regime, a set of complex interfacial features (finger merging, shielding, and pinch-off) whose experimental realization is still not available, are predicted.

  16. Shocks and finite-time singularities in Hele-Shaw flow

    SciTech Connect

    Teodorescu, Razvan; Wiegmann, P; Lee, S-y

    2008-01-01

    Hele-Shaw flow at vanishing surface tension is ill-defined. In finite time, the flow develops cusplike singularities. We show that the ill-defined problem admits a weak dispersive solution when singularities give rise to a graph of shock waves propagating in the viscous fluid. The graph of shocks grows and branches. Velocity and pressure jump across the shock. We formulate a few simple physical principles which single out the dispersive solution and interpret shocks as lines of decompressed fluid. We also formulate the dispersive solution in algebro-geometrical terms as an evolution of Krichever-Boutroux complex curve. We study in details the most generic (2,3) cusp singularity which gives rise to an elementary branching event. This solution is self-similar and expressed in terms of elliptic functions.

  17. The effect of surface tension on steadily translating bubbles in an unbounded Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Green, Christopher C.; Lustri, Christopher J.; McCue, Scott W.

    2017-05-01

    New numerical solutions to the so-called selection problem for one and two steadily translating bubbles in an unbounded Hele-Shaw cell are presented. Our approach relies on conformal mapping which, for the two-bubble problem, involves the Schottky-Klein prime function associated with an annulus. We show that a countably infinite number of solutions exist for each fixed value of dimensionless surface tension, with the bubble shapes becoming more exotic as the solution branch number increases. Our numerical results suggest that a single solution is selected in the limit that surface tension vanishes, with the scaling between the bubble velocity and surface tension being different to the well-studied problems for a bubble or a finger propagating in a channel geometry.

  18. Ferrofluid patterns in Hele-Shaw cells: Exact, stable, stationary shape solutions.

    PubMed

    Lira, Sérgio A; Miranda, José A

    2016-01-01

    We investigate a quasi-two-dimensional system composed of an initially circular ferrofluid droplet surrounded by a nonmagnetic fluid of higher density. These immiscible fluids flow in a rotating Hele-Shaw cell, under the influence of an in-plane radial magnetic field. We focus on the situation in which destabilizing bulk magnetic field effects are balanced by stabilizing centrifugal forces. In this framing, we consider the interplay of capillary and magnetic normal traction effects in determining the fluid-fluid interface morphology. By employing a vortex-sheet formalism, we have been able to find a family of exact stationary N-fold polygonal shape solutions for the interface. A weakly nonlinear theory is then used to verify that such exact interfacial solutions are in fact stable.

  19. Billy Shaw Dam and Reservoir : Environmental Assessment and Finding of No Significant Impacts.

    SciTech Connect

    United States. Bonneville Power Administration; Shoshone-Paiute Tribes of the Duck Valley Reservation, Nevada.

    1997-03-01

    This notice announces BPA`s decision to fund the construction, operation, and maintenance of the Billy Shaw Dam and Reservoir on the Duck Valley Reservation. This project is part of a continuing effort to address system-wide fish and wildlife losses caused by the development of the hydropower system in the Columbia River Basin. BPA has prepared an Environmental Assessment (EA) evaluating the potential environmental impacts of the proposed project. Based on the analysis in the EA, BPA has determined that the Proposed Action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required and BPA is issuing this FONSI.

  20. Ferrofluid patterns in Hele-Shaw cells: Exact, stable, stationary shape solutions

    NASA Astrophysics Data System (ADS)

    Lira, Sergio; Miranda, Jose

    2016-11-01

    We investigate a quasi-two-dimensional system composed by an initially circular ferrofluid droplet surrounded by a nonmagnetic fluid of higher density. These immiscible fluids flow in a rotating Hele-Shaw cell, under the influence of an in-plane radial magnetic field. We focus on the situation in which destabilizing bulk magnetic field effects are balanced by stabilizing centrifugal forces. In this framing, we consider the interplay of capillary and magnetic normal traction effects in determining the fluid-fluid interface morphology. By employing a vortex-sheet formalism we have been able to find a family of exact stationary N-fold polygonal shape solutions for the interface. A weakly nonlinear theory is then used to verify that such exact interfacial solutions are in fact stable. We thank CNPq (Brazilian Research Council) for financial support.

  1. Janus Gel Fabrication Using Liquid Drop Coalescence and Limited Mixing in the Hele-Shaw Geometry

    NASA Astrophysics Data System (ADS)

    Gonzalez, Brittany; Moran, Alexis; Lee, Donghee; Ryu, Sangjin

    2015-11-01

    Hydrogel substrates of tunable stiffness have been actively utilized for in vitro cell mechanobiology study. Here we present a new method to fabricate Janus polyacrylamide gel based on limited mixing between liquid drops coalescing in the Hele-Shaw geometry. Two pre-polymer drops with different concentrations were sandwiched and squeezed between two parallel glass surfaces. Once the drops coalesced in the decreased gap between the surfaces, gelation was initiated by UV light exposure with various time delays. AFM nano-indentation was utilized to map the Young's modulus of obtained gels. Fabricated Janus gels had two regions of different Young's moduli interfaced by the stiffness gradient zone, and the width of the gradient zone increased with the delay time. We acknowledge support from Bioengineering for Human Health grant from UNL and UNMC, and NSF REU grant for UNL.

  2. Cost analysis of paint-waste-incineration technology at U. S. Army depots. Final report, Nov 88-Oct 91

    SciTech Connect

    Hall, F.D.; McKibben, R.S.

    1991-10-01

    The U.S. Army Depot System Command (DESCOM) has 16 maintenance depots located throughout the U.S. Several army depots generate paint wastes that must be disposed of. These depots are located in different parts of the country, and a comprehensive strategy is required to manage the disposal of the paint wastes generated at the individual depots. Incineration is a candidate technology for disposal of such wastes. This report presents an economic analysis of developing an incineration strategy. The economic analysis of paint waste incineration was limited to six major maintenance depots: Anniston, Corpus Christi, Letterkenny, Red River, Tobyhanna, and Tooele. These particular depots are included in the analysis because they are responsible for the majority of all paint wastes generated annually be DESCOM. Three scenarios were evaluated: (1) locating an incinerator at each depot, (2) locating an incinerator at a single site and transporting waste from other depots to this location, and (3) using multiple units at two or more depots. The analysis considers the locations of the army depots, the types and quantities of the wastes they generate, and transportation of the wastes. It also assumes that the individual army depots are equally equipped for proper management of the paint waste by the incineration technology and that the waste can be transferred between the depots without any restrictions. It is further assumed that only incinerable paint wastes will be treated.

  3. Tsunakawa-Shaw method - an absolute paleointensity technique using alternating field demagnetization

    NASA Astrophysics Data System (ADS)

    Yamamoto, Y.; Mochizuki, N.; Shibuya, H.; Tsunakawa, H.

    2015-12-01

    Among geologic materials volcanic rocks have been typically used to deduce an absolute paleointensity. In the last decade, however, there seems a becoming consensus that volcanic rocks are not so ideal materials due to such as magnetic grains other than non-interacting single domain particles. One approach to obtain a good paleointensity estimate from the rocks is to reduce and correct the non-ideality, suppress alterations in laboratory and screen out suspicious results. We have been working on a development and an application of the Tsunakawa-Shaw method, which has been previously called the LTD-DHT Shaw method. This method is an AF(alternating field)-based technique and thus a paleointensity is estimated using coercivity spectra. To reduce the non-ideality, all remanences undergo low-temperature demagnetization (LTD) before any AF demagnetizations to remove multi-domain like component. To correct the non-ideality, anhysteretic remanent magnetizations (ARMs) are imparted with their directions parallel to natural remanent magnetizations and laboratory-imparted thermoremanent magnetizations (TRMs) and measured before and after laboratory heating. These ARMs are used to correct remanence anisotropies, possible interaction effects originated from the non-ideal grains and TRM changes caused by laboratory alterations. TRMs are imparted by heating specimens above their Curie temperatures and then cooling to room temperature at once to simulate nature conditions. These cycles are done in vacuum to suppress alterations in laboratory. Obtained results are judged by selection criteria, including a check for validity of the ARM corrections.It has been demonstrated that successful paleointensities are obtained from historical lavas in Japan and Hawaii, and from baked clay samples from a reconstructed ancient kiln, with the flow-mean precision of 5-10%. In case of old volcanic rocks, however, the method does not necessarily seem to be perfect. We will summarize these points in

  4. A study of gas bubbles in liquid mercury in a vertical Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Klaasen, B.; Verhaeghe, F.; Blanpain, B.; Fransaer, J.

    2014-01-01

    High-quality observations of mesoscopic gas bubbles in liquid metal are vital for a further development of pyrometallurgical gas injection reactors. However, the opacity of metals enforces the use of indirect imaging techniques with limited temporal or spatial resolution. In addition, accurate interface tracking requires tomography which further complicates the design of a high-temperature experimental setup. In this paper, an alternative approach is suggested that circumvents these two main restrictions. By injecting gas in a thin layer of liquid metal entrapped between two flat and closely spaced plates, bubbles in a Hele-Shaw flow regime are generated. The resulting quasi-2D multiphase flow phenomena can be fully captured from a single point of view and, when using a non-wetted transparent plate material, the bubbles can be observed directly. The feasibility of this approach is demonstrated by observations on buoyancy-driven nitrogen bubbles in liquid mercury in a vertical Hele-Shaw cell. By using a moving high-speed camera to make continuous close up recordings of individual bubbles, the position and geometry of these bubbles are quantified with a high resolution along their entire path. After a thorough evaluation of the experimental accuracy, this information is used for a detailed analysis of the bubble expansion along the path. While the observed bubble growth is mainly caused by the hydrostatic pressure gradient, a careful assessment of the volume variations for smaller bubbles shows that an accurate bubble description should account for significant dynamic pressure variations that seem to be largely regime dependent.

  5. Gas production and transport in artificial sludge depots.

    PubMed

    van Kessel, T; van Kesteren, W G M

    2002-01-01

    This paper presents a study to determine the impact of gas production in dredging sludge on the storage capacity of artificial sludge depots. Gas is produced as a result of the decomposition of organic material present in dredging spoil. This process, in which methane and carbon dioxide are formed, may lead to expansion of sludge layers, partly or even completely counterbalancing consolidation. The study shows that, even with a very conservative estimation of the rate of gas production, accumulation of gas occurs as convective and diffusive transport proceed very slowly. Nucleation of gas bubbles occurs already at a limited oversaturation of pore water. During their growth, bubbles push aside the surrounding grain matrix. Resulting stresses may initiate cracks around bubbles. If these cracks join, they may form channels stretching out to the depot surface and along which gas may escape. However, channels are only stable to a limited depth below which bubble accumulation may continue. The gas content at which sufficient cracks and channels are formed to balance the rate of gas production with the rate of outflow strongly depends on the constitutive properties of the dredging sludge considered. In sludge with a high shear strength (> 10 kPa), stable channels are created already at low deformations. However, a large expansion may occur in sludge with a low strength. The present study shows that accumulation of gas may continue until a bulk density less than that of water is attained. This is equivalent to a gas fraction of about 25-37%, depending on the initial water content of the sludge. Only then can gas escape as a result of instabilities in the sediment matrix. This should be well taken into account during the design and management of artificial depots.

  6. Diversity of lipid mediators in human adipose tissue depots

    PubMed Central

    Clària, Joan; Nguyen, Binh T.; Madenci, Arin L.; Ozaki, C. Keith

    2013-01-01

    Adipose tissue is a heterogeneous organ with remarkable variations in fat cell metabolism depending on the anatomical location. However, the pattern and distribution of bioactive lipid mediators between different fat depots and their relationships in complex diseases have not been investigated. Using LC-MS/MS-based metabolo-lipidomics, here we report that human subcutaneous (SC) adipose tissues possess a range of specialized proresolving mediators (SPM) including resolvin (Rv) D1, RvD2, protectin (PD) 1, lipoxin (LX) A4, and the monohydroxy biosynthetic pathway markers of RvD1 and PD1 (17-HDHA), RvE1 (18-HEPE), and maresin 1 (14-HDHA). The “classic” eicosanoids prostaglandin (PG) E2, PGD2, PGF2α, leukotriene (LT) B4, 5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE were also identified in SC fat. SC fat from patients with peripheral vascular disease (PVD) exhibited a marked deficit in PD1 and 17-HDHA levels. Compared with SC, perivascular adipose tissue displayed higher SPM levels, suggesting an enhanced resolution capacity in this fat depot. In addition, augmented levels of eicosanoids and SPM were observed in SC fat surrounding foot wounds. Notably, the profile of SC PGF2α differed significantly when patients were grouped by body mass index (BMI). In the case of peri-wound SC fat, BMI negatively correlated with PGE2. In this tissue, proresolving mediators RvD2 and LXA4 were identified in lower levels than the proinflammatory LTB4. Collectively, these findings demonstrate a diverse distribution of bioactive lipid mediators depending on the localization of human fat depots and uncover a specific SPM pattern closely associated with PVD. PMID:23364264

  7. Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

    PubMed Central

    Zhu, Yi; Karagiannides, Iordanes; Pothoulakis, Charalabos; Jensen, Michael D.; Kirkland, James L.

    2014-01-01

    Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones, development, and aging. Preadipocyte replication and differentiation, developmental gene expression, susceptibility to apoptosis and cellular senescence, vascularity, inflammatory cell infiltration, and adipokine secretion vary among depots, as do fatty-acid handling and mechanisms of enlargement with positive-energy and loss with negative-energy balance. How interdepot differences in these molecular, cellular, and pathophysiological properties are related is incompletely understood. Whether fat redistribution causes metabolic disease or whether it is a marker of underlying processes that are primarily responsible is an open question. PMID:23583168

  8. Depot Closings and the Destruction of Western Civilization

    DTIC Science & Technology

    1998-01-01

    wx+ w hdu edu/ndu/mss/bookslessa/essamddm.html 3 Setting Off a Cham Reaction Durmg the cold war, DOD built up a serves of supply and repair depots...the An Force’s explanatron Representatrve Don Nickles R -OK, noted “What’s Cahforma7 Ten percent of the electoral votes It makes one wonder ” Other...Reahgmnent Conumss~on, mtemew wnh author at Nahonal War College. 23 October, 1997 ’ Cassata , Donna, “GAO Faults Au Force Declslon to Shut No Repau

  9. Energy engineering analysis program, Anniston Army Depot. Final report

    SciTech Connect

    1984-12-01

    This report presents the results of the Energy Engineering Analysis Program (EEAP) study (Increment F) conducted at the Anniston Army Depot, Anniston, Alabama by Science Applications, Incorporated (SAl) under Contract No. DACAOl-83-C-0099. The report includes an analysis of energy conservation projects that can be accomplished using various Army funds, Post funds, and new management procedures. Also found in the report is a complete listing of recently implemented energy conservation projects, recommended similar future projects and a presentation of current and projected Post energy usage. The result of this analysis indicates that current energy use (FY 1983) can be reduced by 23 percent if these recommendations are adopted.

  10. Depot effect of bioactive components in experimental membrane filtrations

    NASA Astrophysics Data System (ADS)

    Mitev, D.; Peshev, D.; Peev, G.; Peeva, L.

    2017-01-01

    Depot effects were found to be accompanying phenomena of membrane separation processes. Accumulation of target species in the membrane matrix during feasibility tests can hamper proper conclusions or compromise the filtration results. Therefore, we investigated the effects of delayed membrane release of chlorogenic acid and caffeine, considered as key compounds of interest in spent coffee products’ recovery treatment. Permeate fluxes and key components release were studied in course of 24 hours via nanofiltration of pure solvent, both immediately after the mock solution filtration and after idle stay. Conclusions are drawn and recommendations advised for proper analysis of experimental data on membrane screening.

  11. The transportation depot: An orbiting vehicle support facility

    NASA Technical Reports Server (NTRS)

    Kaszubowski, Martin J.; Ayers, J. Kirk

    1992-01-01

    This paper describes the details of an effort to produce conceptual designs for an orbiting platform, called a transportation depot, to handle assembly and processing of lunar, Martian, and related vehicles. High-level requirements for such a facility were established, and several concepts were developed to meet those requirements. By showing that the critical rigid-body momentum characteristics of each concept are similar to those of the dual-keel space station, some insight was gained about the controllability and utility of this type of facility. Finally, several general observations were made that highlight the advantages and disadvantages of particular design features.

  12. In-Space Cryogenic Propellant Depot (ISCPD) Architecture Definitions and Systems Studies

    NASA Technical Reports Server (NTRS)

    Fikes, John C.; Howell, Joe T.; Henley, Mark

    2006-01-01

    The objectives of the ISCPD Architecture Definitions and Systems Studies were to determine high leverage propellant depot architecture concepts, system configuration trades, and related technologies to enable more ambitious and affordable human and robotic exploration of the Earth Neighborhood and beyond. This activity identified architectures and concepts that preposition and store propellants in space for exploration and commercial space activities, consistent with Exploration Systems Research and Technology (ESR&T) objectives. Commonalities across mission scenarios for these architecture definitions, depot concepts, technologies, and operations were identified that also best satisfy the Vision of Space Exploration. Trade studies were conducted, technology development needs identified and assessments performed to drive out the roadmap for obtaining an in-space cryogenic propellant depot capability. The Boeing Company supported the NASA Marshall Space Flight Center (MSFC) by conducting this Depot System Architecture Development Study. The primary objectives of this depot architecture study were: (1) determine high leverage propellant depot concepts and related technologies; (2) identify commonalities across mission scenarios of depot concepts, technologies, and operations; (3) determine the best depot concepts and key technology requirements and (4) identify technology development needs including definition of ground and space test article requirements.

  13. An Analysis of the Cost Accounting System for the Depot Maintenance Service, Air Force Industrial Fund.

    DTIC Science & Technology

    1987-09-01

    Requirements .. ..... 11 * Current Cost Accounting System .. ...... 15 Summary ................... 18 III. Methodology. ................... 19 Data Collection...for depot maintenance operations. The third section describes the current cost accounting system used within the AFLC Depot Maintenance. Management...and provide recommendations for further research. 48 V. Conclusions and Recommendations The current cost accounting system works. Most of the

  14. Study of Using Excess Stock to Reduce Naval Aviation Depot-Level Repairable Piece Part Backorders

    DTIC Science & Technology

    2016-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT STUDY OF USING EXCESS STOCK TO REDUCE NAVAL AVIATION... STUDY OF USING EXCESS STOCK TO REDUCE NAVAL AVIATION DEPOT-LEVEL REPAIRABLE PIECE PART BACKORDERS 5. FUNDING NUMBERS 6. AUTHOR(S) Jennifer L...unlimited. STUDY OF USING EXCESS STOCK TO REDUCE NAVAL AVIATION DEPOT-LEVEL REPAIRABLE PIECE PART BACKORDERS Jennifer L. Custard, Lieutenant

  15. Fuel flexible fuel injector

    DOEpatents

    Tuthill, Richard S; Davis, Dustin W; Dai, Zhongtao

    2015-02-03

    A disclosed fuel injector provides mixing of fuel with airflow by surrounding a swirled fuel flow with first and second swirled airflows that ensures mixing prior to or upon entering the combustion chamber. Fuel tubes produce a central fuel flow along with a central airflow through a plurality of openings to generate the high velocity fuel/air mixture along the axis of the fuel injector in addition to the swirled fuel/air mixture.

  16. Nonlinear longitudinal oscillations of fuel in rockets feed lines with gas-liquid damper

    NASA Astrophysics Data System (ADS)

    Avramov, K. V.; Filipkovsky, S.; Tonkonogenko, A. M.; Klimenko, D. V.

    2016-03-01

    The mathematical model of the fuel oscillations in the rockets feed lines with gas-liquid dampers is derived. The nonlinear model of the gas-liquid damper is suggested. The vibrations of fuel in the feed lines with the gas-liquid dampers are considered nonlinear. The weighted residual method is applied to obtain the finite degrees of freedom nonlinear model of the fuel oscillations. Shaw-Pierre nonlinear normal modes are applied to analyze free vibrations. The forced oscillations of the fuel at the principle resonances are analyzed. The stability of the forced oscillations is investigated. The results of the forced vibrations analysis are shown on the frequency responses.

  17. Cryogenic thermal system analysis for orbital propellant depot

    NASA Astrophysics Data System (ADS)

    Chai, Patrick R.; Wilhite, Alan W.

    2014-09-01

    In any manned mission architecture, upwards of seventy percent of all payload delivered to orbit is propellant, and propellant mass fraction dominates almost all transportation segments of any mission requiring a heavy lift launch system like the Saturn V. To mitigate this, the use of an orbital propellant depot has been extensively studied. In this paper, a thermal model of an orbital propellant depot is used to examine the effects of passive and active thermal management strategies. Results show that an all passive thermal management strategy results in significant boil-off for both hydrogen and oxygen. At current launch vehicle prices, these boil-offs equate to millions of dollars lost per month. Zero boil-off of propellant is achievable with the use of active cryocoolers; however, the cooling power required to produce zero-boil-off is an order of magnitude higher than current state-of-the-art cryocoolers. This study shows a zero-boil-off cryocooler minimum power requirement of 80-100 W at 80 K for liquid oxygen, and 100-120 W at 20 K for liquid hydrogen for a representative Near-Earth Object mission. Research and development effort is required to improve the state-of-the-arts in-space cryogenic thermal management.

  18. Artificial immune algorithm for multi-depot vehicle scheduling problems

    NASA Astrophysics Data System (ADS)

    Wu, Zhongyi; Wang, Donggen; Xia, Linyuan; Chen, Xiaoling

    2008-10-01

    In the fast-developing logistics and supply chain management fields, one of the key problems in the decision support system is that how to arrange, for a lot of customers and suppliers, the supplier-to-customer assignment and produce a detailed supply schedule under a set of constraints. Solutions to the multi-depot vehicle scheduling problems (MDVRP) help in solving this problem in case of transportation applications. The objective of the MDVSP is to minimize the total distance covered by all vehicles, which can be considered as delivery costs or time consumption. The MDVSP is one of nondeterministic polynomial-time hard (NP-hard) problem which cannot be solved to optimality within polynomial bounded computational time. Many different approaches have been developed to tackle MDVSP, such as exact algorithm (EA), one-stage approach (OSA), two-phase heuristic method (TPHM), tabu search algorithm (TSA), genetic algorithm (GA) and hierarchical multiplex structure (HIMS). Most of the methods mentioned above are time consuming and have high risk to result in local optimum. In this paper, a new search algorithm is proposed to solve MDVSP based on Artificial Immune Systems (AIS), which are inspirited by vertebrate immune systems. The proposed AIS algorithm is tested with 30 customers and 6 vehicles located in 3 depots. Experimental results show that the artificial immune system algorithm is an effective and efficient method for solving MDVSP problems.

  19. Energy engineering analysis program at New Cumberland Army Depot, PA. Volume 1: Executive summary. Final report

    SciTech Connect

    1984-03-01

    This is the Corrected Final Report on Increments A through G of the Energy Engineering Analysis Program (EEAP) at New Cumberland Army Depot (NCAD). This project has been conducted under the Norfolk District, Corps of Engineers Contract No. DACA 65-8O-C-0O14, by PRC Systems Services, Cocoa Beach, FL. During Increments A and B, four modification projects were recommended for funding under the Energy Conservation Investment Program (ECIP). Increment G resulted in three recommended projects and Increment E determined the feasibility of a new, coal-fired central steam plant. Studies conducted during Increments C, D, and F concluded that none of the proposed work was economically feasible under applicable guidelines. Actual energy consumption at NCAD was determined from electricity billings and from fuel oil delivery records. Costs were taken. from contracts and service agreements that were in force at the times the various increments were undertaken. Using conversion factors specified in the Army Facilities Energy Plan and prices in effect during the year, the following summarizes the total energy picture for fiscal year (FY) 83.

  20. Cation ordering in orthopyroxenes and cooling rates of meteorites: Low temperature cooling rates of Estherville, Bondoc and Shaw

    NASA Technical Reports Server (NTRS)

    Ganguly, J.; Yang, H.; Ghose, S.

    1993-01-01

    The cooling rates of meteorites provide important constraints on the size of their parent bodies, and their accretionary and evolutionary histories. However, the cooling rates obtained so far from the commonly used metallographic, radiometric and fission-track methods have been sometimes quite controversial, such as in the case of the mesosiderites and the meteorite Shaw. We have undertaken a systematic study of the cooling rates of meteorites using a different approach, which involves single crystal x-ray determination of Fe(2+)-Mg ordering in orthopyroxenes (OP(x)) in meteorites, subject to bulk compositional constraints, and numerical simulation of the evolution of the ordering state as a function of cooling rate, within the framework of the thermodynamic and kinetic principles governing cation ordering. We report the results obtained for OP(x) crystals from Shaw and two mesosiderites, Estherville and Bondoc.

  1. Gas-driven displacement of a non-Newtonian liquid in a radial Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    White, Andrew; Ward, Thomas

    2012-11-01

    The displacement of a non-Newtonian liquid by a less viscous fluid has applications in a number of industries such as lubricating oils, injection molding and cement placement in oil wells to name a few. A convenient geometry to study such a problem is that of the Hele-Shaw cell due to its ability to effectively reduce the flow to two dimensions when the gap spacing is much smaller than the other spatial dimensions. We will study the radial displacement of a finite drop of non-Newtonian shear-thinning and extensionally-thickening liquid by a gas at constant pressure in a Hele-Shaw cell with gap spacing O(10-100) microns. Different concentrations of a polymer in oil will be used to examine changes in the displacement rate, residual film thickness and resulting Saffman-Taylor instability as the viscoelastic time scale overtakes that of the bulk displacement.

  2. National Fuel Cell Bus Program: Accelerated Testing Evaluation Report and Appendices, Alameda-Contra Costa Transit District (AC Transit)

    SciTech Connect

    Chandler, K.; Eudy, L.

    2009-01-01

    This is an evaluation of hydrogen fuel cell transit buses operating at AC Transit in revenue service since March 20, 2006 compared to similar diesel buses operating from the same depot. This evaluation report includes results from November 2007 through October 2008. Evaluation results include implementation experience, fueling station operation, fuel cell bus operations at Golden Gate Transit, and evaluation results at AC Transit (bus usage, availability, fuel economy, maintenance costs, and roadcalls).

  3. The search for purpose in a post-Darwinian universe: George Bernard Shaw, 'creative evolution', and Shavian eugenics: 'The dark side of the force'.

    PubMed

    Hale, Piers J

    2006-01-01

    The Irish playwright and socialist George Bernard Shaw has been of marginal concern for historians of biology because his vitalist Lamarckism has been viewed as out of step with contemporary science. However, Julian Huxley and J.B.S. Haldane were certainly of the opinion that Shaw was a man of influence in this regard and took pains to counter his views in their own attempts to engage the public in science. Previously, Shaw's colleague and friend H.G. Wells had also agued with Shaw from his own mechanistic neo-Darwinian perspective. The very public debate between Shaw and Wells, which continued to concern Huxley and Haldane, shows that public concern over the moral implications of Darwinism has a long history. Taking into account the opinions of John Maynard Smith on this matter, I suggest that a consideration of Shaw in this context can give us an understanding of the historical popularity of vitalist teleology as well as of the persistent ambivalence to the non-normative character of Darwinism.

  4. The ethics of killing human/great-ape chimeras for their organs: a reply to Shaw et al.

    PubMed

    Palacios-González, César

    2016-06-01

    The aim of this paper is to critically examine David Shaw, Wybo Dondorp, and Guido de Wert's arguments in favour of the procurement of human organs from human/nonhuman-primate chimeras, specifically from great-ape/human chimeras. My main claim is that their arguments fail and are in need of substantial revision. To prove this I first introduce the topic, and then reconstruct Shaw et al.'s position and arguments. Next, I show that Shaw et al.: (1) failed to properly apply the subsidiarity and proportionality principles; (2) neglected species overlapping cases in their ethical assessment; (3) ignored the ethics literature on borderline persons; and (4) misunderstood McMahan's two-tiered moral theory. These mistakes render an important part of their conclusions either false or problematic to the point that they would no longer endorse them. Finally I will briefly mention a possible multipolar solution to the human organ shortage problem that would reduce the need for chimeras' organs.

  5. Tanker Argus: Re-supply for a LEO Cryogenic Propellant Depot

    NASA Astrophysics Data System (ADS)

    St. Germain, B.; Olds, J.; Kokan, T.; Marcus, L.; Miller, J.

    The Argus reusable launch vehicle (RLV) concept is a single-stage-to-orbit conical, winged bodied vehicle powered by two liquid hydrogen/liquid oxygen supercharged ejector ramjets. The 3rd generation Argus launch vehicle utilizes advanced vehicle technologies along with a Maglev launch assist track. A tanker version of the Argus RLV is envisioned to provide an economical means of providing liquid fuel and oxidizer to an orbiting low-Earth orbit (LEO) propellant depot. This depot could then provide propellant to various spacecraft, including reusable orbital transfer vehicles used to ferry space solar power satellites to geo-stationary orbit. Two different tanker Argus configurations were analyzed. The first simply places additional propellant tanks inside the payload bay of an existing Argus reusable launch vehicle. The second concept is a modified Argus RLV in which the payload bay is removed and the vehicle propellant tanks are stretched to hold extra propellant. An iterative conceptual design process was used to design both Argus vehicles. This process involves various disciplines including aerodynamics, trajectory analysis, weights &structures, propulsion, operations, safety, and cost/economics. The payload bay version of tanker Argus, which has a gross mass of 256.3MT, is designed to deliver a 9.07MT payload to LEO. This payload includes propellant and the tank structure required to secure this propellant in the payload bay. The modified, pure tanker version of Argus has a gross mass of 218.6MT and is sized to deliver a full 9.07MT of propellant to LEO. The economic analysis performed for this study involved the calculation of many factors including the design/development and recurring costs of each vehicle. These results were used along with other economic assumptions to determine the "per kilogram" cost of delivering propellant to orbit. The results show that for a given flight rate the "per kilogram" cost is cheaper for the pure tanker version of Argus

  6. Evaluation of olanzapine pamoate depot in seriously violent males with schizophrenia in the community.

    PubMed

    Kasinathan, John; Sharp, Gillian; Barker, Anthony

    2016-10-01

    Olanzapine is a well established treatment for schizophrenia. The olanzapine pamoate depot (long-acting injectable) formulation improves compliance and clinical trials have shown it to be effective. However, there are no previously published reports evaluating olanzapine depot in violent patients with schizophrenia in the community. We evaluated the clinical efficacy of olanzapine depot, its effect on violence, hospitalization and incarceration in community patients with schizophrenia and prior history of serious violence. This was a retrospective service evaluation in a community forensic psychiatry service where patients had schizophrenia spectrum disorder and a significant history of violence. Treatment resistance, substance use disorders and antisocial personality disorder were common. Nine deidentified patient records were audited for 12 months pre and 12 months post olanzapine depot initiation to identify any clinical changes, breaches of (legislated) psychiatric treatment orders, hospital admission days, days incarcerated and emergency presentations. Community forensic psychiatric patients treated with olanzapine depot showed an improvement in psychotic symptoms (p = 0.008) with overall decreases in violence, supported by reductions in hospitalization days (p = 0.018) and days incarcerated (p = 0.043). Several patients had reduced psychiatric treatment order breaches and emergency presentations. Community forensic psychiatric patients with schizophrenia responded to olanzapine depot with decreased violence and reduced hostility. A depot antipsychotic medication that reduces violence and improves engagement has significant implications for greater effective community management of forensic patients with schizophrenia.

  7. Evaluation of olanzapine pamoate depot in seriously violent males with schizophrenia in the community

    PubMed Central

    Kasinathan, John; Sharp, Gillian; Barker, Anthony

    2016-01-01

    Objectives: Olanzapine is a well established treatment for schizophrenia. The olanzapine pamoate depot (long-acting injectable) formulation improves compliance and clinical trials have shown it to be effective. However, there are no previously published reports evaluating olanzapine depot in violent patients with schizophrenia in the community. We evaluated the clinical efficacy of olanzapine depot, its effect on violence, hospitalization and incarceration in community patients with schizophrenia and prior history of serious violence. Methods: This was a retrospective service evaluation in a community forensic psychiatry service where patients had schizophrenia spectrum disorder and a significant history of violence. Treatment resistance, substance use disorders and antisocial personality disorder were common. Nine deidentified patient records were audited for 12 months pre and 12 months post olanzapine depot initiation to identify any clinical changes, breaches of (legislated) psychiatric treatment orders, hospital admission days, days incarcerated and emergency presentations. Results: Community forensic psychiatric patients treated with olanzapine depot showed an improvement in psychotic symptoms (p = 0.008) with overall decreases in violence, supported by reductions in hospitalization days (p = 0.018) and days incarcerated (p = 0.043). Several patients had reduced psychiatric treatment order breaches and emergency presentations. Conclusions: Community forensic psychiatric patients with schizophrenia responded to olanzapine depot with decreased violence and reduced hostility. A depot antipsychotic medication that reduces violence and improves engagement has significant implications for greater effective community management of forensic patients with schizophrenia. PMID:27721969

  8. Waste reduction for electroless nickel-plating solutions at U. S. Army depots. Final report, Oct 91-Apr 92

    SciTech Connect

    Davis, J.S.

    1992-06-10

    Waste minimization is one of the most pressing environmental issues currently facing U.S. Army depots. The U.S. Army Toxic and Hazardous Materials Agency (USATHAMA) conducts research and development to support Army depots in implementing technologies to reduce waste generation. The Joint Depot Environmental Panel (JDEP) identified electroless nickel (EN) plating, which is currently used at Corpus Christi Army Depot (CCAD), Red River Army Depot (RRAD), and Sacramento Army Depot (SAAD) as a target for waste minimization research. This report presents the results of an evaluation conducted by USA regarding minimizing waste from EN-plating operations. The objective of this evaluation was to formulate recommendations for depots regarding implementation of waste minimization technologies. This evaluation was performed through site visits, a literature search, and discussions with vendors of EN processes and decontamination technologies.

  9. Coalescence dynamics of a Non-Newtonian drop in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Angeli, Panagiota; Voulgaropoulos, Victor; Chinaud, Maxime

    2016-11-01

    In this study, the quasi-2D coalescence of an aqueous droplet with a flat interface is studied. The two immiscible liquids used in the coalescence experiments are a water/glycerol mixture and low viscosity oil. Experiments are conducted in a Hele-Shaw cell with an aspect ratio of 14 by 8 by 0.125 cm while time resolved velocity fields are obtained by using high-speed bright field Particle Image Velocimetry measurements. The aim of the present study is to investigate the effect of a polymer (i.e. xanthan gum), which results in a shear-thinning behaviour of the aqueous phase. It was found that the time evolution of the neck at the initial stages of coalescence follows a linear trend, which suggests that the shear-thinning behaviour at the neck region at this stage of coalescence can be considered quasi-constant in time. In addition, velocity and vorticity fields are computed inside the coalescing droplet and the bulk homophase. It is found that two pair of counter rotating vortices are generated just after the rupture of the film which separates the drop from the homophase. Furthermore, the polymer addition reduced the magnitude of the corresponding vorticity peaks in the drop and slowed down the coalescence dynamics. Project funded under the UK Engineering and Physical Sciences Research Council (EPSRC) Programme Grant MEMPHIS.

  10. New Trends on Antineoplastic Therapy Research: Bullfrog (Rana catesbeiana Shaw) Oil Nanostructured Systems.

    PubMed

    Amaral-Machado, Lucas; Xavier-Júnior, Francisco H; Rutckeviski, Renata; Morais, Andreza R V; Alencar, Éverton N; Dantas, Teresa R F; Cruz, Ana K M; Genre, Julieta; da Silva-Junior, Arnóbio A; Pedrosa, Matheus F F; Rocha, Hugo A O; Egito, Eryvaldo S T

    2016-04-30

    Bullfrog oil is a natural product extracted from the Rana catesbeiana Shaw adipose tissue and used in folk medicine for the treatment of several diseases. The aim of this study was to evaluate the extraction process of bullfrog oil, to develop a suitable topical nanoemulsion and to evaluate its efficacy against melanoma cells. The oil samples were obtained by hot and organic solvent extraction processes and were characterized by titration techniques and gas chromatography mass spectrometry (GC-MS). The required hydrophile-lipophile balance and the pseudo-ternary phase diagram (PTPD) were assessed to determine the emulsification ability of the bullfrog oil. The anti-tumoral activity of the samples was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for normal fibroblast (3T3) and melanoma (B16F10) cell lines. Both extraction methods produced yielded around 60% and the oil was mainly composed of unsaturated compounds (around 60%). The bullfrog oil nanoemulsion obtained from PTPD presented a droplet size of about 390 nm and polydispersity = 0.05 and a zeta potential of about -25 mV. Both the bullfrog oil itself and its topical nanoemulsion did not show cytotoxicity in 3T3 linage. However, these systems showed growth inhibition in B16F10 cells. Finally, the bullfrog oil presented itself as a candidate for the development of pharmaceutical products free from cytotoxicity and effective for antineoplastic therapy.

  11. Adhesion and fingering in the lifting Hele-Shaw cell: role of the substrate.

    PubMed

    Sinha, S; Dutta, T; Tarafdar, S

    2008-03-01

    The lifting Hele-Shaw cell (LHSC) is used to study adhesion as well as viscous fingering. In the present paper we report a series of observations of development of the interface for different viscous fluids, both Newtonian and non-Newtonian, in a LHSC operated at a constant lifting force. Glass and perspex are used as the plates in two different sets of experiments. The objectives are 1) to measure the time required to separate the plates as a function of the lifting force and 2) to note the force above which viscous fingering appears. We find that for the Newtonian fluids, the plate separation time follows a universal power law with the lifting force, irrespective of fluid and substrate. The non-Newtonian fluids too, with proper scaling obey the same power law. The appearance of fingering, however, depends on the properties of the fluid as well as the substrate. We suggest a modified form of the capillary number which controls the onset of fingering; this new quantity, termed the "fingering parameter" involves the dielectric constants of the substrate and fluid in addition to the viscosity and surface tension.

  12. Observing Nitrogen Bubbles in Liquid Zinc in a Vertical Hele-Shaw Cell

    NASA Astrophysics Data System (ADS)

    Klaasen, Bart; Verhaeghe, Frederik; Blanpain, Bart; Fransaer, Jan

    2015-04-01

    Observations of gas bubbles in liquid metal are strongly hindered by the opacity of metals. To circumvent this limitation, the authors recently proposed to study such systems under quasi-2D flow conditions in a Hele-Shaw cell. The current paper presents a successful application of this approach for nitrogen bubbles in liquid zinc at 973 K (700 °C) in a fused quartz cell with a thickness of 1.5 mm. At low oxygen levels, the cell walls are not wetted by the liquid zinc, and bubbles can be observed directly through the transparent cell walls. Furthermore, using a moving high-speed camera that travels upwards with the bubbles, their properties are quantified in detail along the entire trajectory. In the range of equivalent diameters between 5.9 and 9.0 mm, this reveals a single periodic flow regime in which bubbles follow a sinusoidal path with a characteristic frequency of 3.31 Hz. In addition, systematic intermediate accelerations are observed of which the origin remains unexplained. Considering the unprecedented resolution of such observations for bubbles in liquid metals, especially at high temperatures, it is expected that this approach will contribute to a better understanding of the mechanisms that govern gas injection in pyrometallurgy.

  13. Three-dimensional simulation of droplet migration in a Hele-Shaw microchannel

    NASA Astrophysics Data System (ADS)

    Ling, Yue; Fullana, Jose-Maria; Popinet, Stephane; Josserand, Christophe

    2015-11-01

    Droplet-based microfluidics is a promising tool for performing biomehcanical and chemical assays. Three-dimensional simulations are performed in this work to investigate the migration of a droplet in a confined microchannel (a Hele-Shaw cell). As the droplet moves in the channel, a thin film is formed between the droplet and the wall. The thickness of the film can be two orders of magnitude smaller than the channel height. Furthermore, the time step which is mainly controlled by the surface tension effect becomes very small for low Capillary number. Therefore, numerical simulation of droplet migration in microchannel is challenging. The present simulations are conducted with a two-phase flow solver (GERRIS) on an adaptive mesh. The interface between the two phases is captured by the Volume-of-fluid method. The droplet dynamics are very different as the aspect ratio (the ratio between the droplet diameter and the channel height) varies from smaller to larger than unity. For droplets of large aspect ratio, the droplet velocity is mainly dictated by the dynamics of the thin film. The simulations also show that the flow around the droplet is three dimensional and has a significant impact on the droplet shape. ANR-13-BS09-0011.

  14. Stability of the fluid interface in a Hele-Shaw cell subjected to horizontal vibrations

    NASA Astrophysics Data System (ADS)

    Lyubimova, T. P.; Lyubimov, D. V.; Sadilov, E. S.; Popov, D. M.

    2017-07-01

    The stability of the horizontal interface of two immiscible viscous fluids in a Hele-Shaw cell subject to gravity and horizontal vibrations is studied. The problem is reduced to the generalized Hill equation, which is solved analytically by the multiple scale method and numerically. The long-wave instability, the resonance (parametric resonance) excitation of waves at finite frequencies of vibrations (for the first three resonances), and the limit of high-frequency vibrations are studied analytically under the assumption of small amplitudes of vibrations and small viscosity. For finite amplitudes of vibrations, finite wave numbers, and finite viscosity, the study is performed numerically. The influence of the specific natural control parameters and physical parameters of the system on its instability threshold is discussed. The results provide extension to other results [J. Bouchgl, S. Aniss, and M. Souhar, Phys. Rev. E 88, 023027 (2013), 10.1103/PhysRevE.88.023027], where the authors considered a similar problem but took into account viscosity in the basic state and did not consider it in the equations for perturbations.

  15. Absolute Paleointensity Estimates using Combined Shaw and Pseudo-Thellier Experimental Protocols

    NASA Astrophysics Data System (ADS)

    Foucher, M. S.; Smirnov, A. V.

    2016-12-01

    Data on the long-term evolution of Earth's magnetic field intensity have a great potential to advance our understanding of many aspects of the Earth's evolution. However, paleointensity determination is one of the most challenging aspects of paleomagnetic research so the quantity and quality of existing paleointensity data remain limited, especially for older epochs. While the Thellier double-heating method remains to be the most commonly used paleointensity technique, its applicability is limited for many rocks that undergo magneto-mineralogical alteration during the successive heating steps required by the method. In order to reduce the probability of alteration, several alternative methods that involve a limited number of or no heating steps have been proposed. However, continued efforts are needed to better understand the physical foundations and relative efficiency of reduced/non-heating methods in recovering the true paleofield strength and to better constrain their calibration factors. We will present the results of our investigation of synthetic and natural magnetite-bearing samples using a combination of the LTD-DHT Shaw and pseudo-Thellier experimental protocols for absolute paleointensity estimation.

  16. Low frequency vibration induced streaming in a Hele-Shaw cell

    SciTech Connect

    Costalonga, M.; Brunet, P.; Peerhossaini, H.

    2015-01-15

    When an acoustic wave propagates in a fluid, it can generate a second order flow whose characteristic time is much longer than the period of the wave. Within a range of frequency between ten and several hundred Hz, a relatively simple and versatile way to generate streaming flow is to put a vibrating object in the fluid. The flow develops vortices in the viscous boundary layer located in the vicinity of the source of vibrations, leading in turn to an outer irrotational streaming called Rayleigh streaming. Because the flow originates from non-linear time-irreversible terms of the Navier-Stokes equation, this phenomenon can be used to generate efficient mixing at low Reynolds number, for instance in confined geometries. Here, we report on an experimental study of such streaming flow induced by a vibrating beam in a Hele-Shaw cell of 2 mm span using long exposure flow visualization and particle-image velocimetry measurements. Our study focuses especially on the effects of forcing frequency and amplitude on flow dynamics. It is shown that some features of this flow can be predicted by simple scaling arguments and that this vibration-induced streaming facilitates the generation of vortices.

  17. Bubble dynamics inside an outgassing hydrogel confined in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Haudin, Florence; Noblin, Xavier; Bouret, Yann; Argentina, Médéric; Raufaste, Christophe

    2016-08-01

    We report an experimental study of bubble dynamics in a non-Newtonian fluid subjected to a pressure decrease. The fluid is a hydrogel, composed of water and a synthetic clay, prepared and sandwiched between two glass plates in a Hele-Shaw geometry. The rheological properties of the material can be tuned by the clay concentration. As the imposed pressure decreases, the gas initially dissolved in the hydrogel triggers bubble formation. Different stages of the process are observed: bubble nucleation, growth, interaction, and creation of domains by bubble contact or coalescence. Initially bubble behave independently. They are trapped and advected by the mean deformation of the hydrogel, and the bubble growth is mainly driven by the diffusion of the dissolved gas through the hydrogel and its outgassing at the reactive-advected hydrogel-bubble interface. In this regime, the rheology of the fluid does not play a significant role on the bubble growth. A model is proposed and gives a simple scaling that relates the bubble growth rate and the imposed pressure. Carbon dioxide is shown to be the gas at play, and the hydrogel is degassing at the millimeter scale as a water solution does at a smaller scale. Later, bubbles are not independent anymore. The growth rate decreases, and the morphology becomes more anisotropic as bubbles interact because they are separated by a distance smaller than the individual stress field extension. Our measurements show that the interaction distance scales with the bubbles' size.

  18. Where do interjections come from? A psycholinguistic analysis of Shaw's Pygmalion.

    PubMed

    O'Connell, Daniel C; Kowal, Sabine

    2005-09-01

    Starting from our recent findings regarding emotional and initializing functions of interjections in TV and radio interviews (Kowal & O'Connell, 2004b; O'Connell & Kowal, in press; O'Connell, Kowal, & Ageneau, 2005), we used the book and script of Shaw (1916/1969) and the audiotape of the motion picture (Pascal, Asquith, & Howard, 1938) Pygmalion to investigate how actors use interjections to express emotions. The following hypotheses were tested: (1) The actors use the written cues selectively in their oral performance by substituting, adding, and deleting interjections; (2) primary interjections added by the actors are less conventional than those in the written text; (3) durations and number of syllables of Eliza Doolittle's spoken renditions of her signature interjection ah-ah-ah-ow-ow-ow-oo do not correlate with the length in letters and syllables of the written versions; and (4) there is no evidence for Ameka's (1992b, 1994) characterization of interjections as temporally isolated, i.e., preceded and followed by silent pauses, in consequence of their syntactic isolation. Our findings confirmed all the hypotheses except for one unexpectedly significant correlation between number of syllables in Eliza Doolittle's signature interjection in the written version and duration in seconds of the spoken version thereof. The common thread throughout these data is the actor's need to personalize emotions in a dramatic performance--by means of interjections other than those provided in the written text. In this process of personalization, the emotional and initializing functions of interjections are confirmed.

  19. Fluid front morphologies in gap-modulated Hele-Shaw cells

    NASA Astrophysics Data System (ADS)

    Díaz-Piola, Lautaro; Planet, Ramon; Campàs, Otger; Casademunt, Jaume; Ortín, Jordi

    2017-09-01

    We consider the displacement of an inviscid fluid (air) by a viscous fluid (oil) in a narrow channel with gap-thickness modulations. The interfacial dynamics of this problem is strongly nonlocal and exhibits competing effects from capillarity and permeability. We derive analytical predictions of steady-state front morphologies, which are exact at linear level in the case of a persistent modulation in the direction of front advancement. The theoretical predictions are in good agreement with experimental measurements of steady-state front morphologies obtained in a Hele-Shaw cell with modulations of the channel depth, consisting on three parallel tracks of reduced depth, for small gap modulations. The relative average distance between theoretical and experimental fronts in the region around the central track is smaller than about 4 % , provided that the height of the tracks is less than 13 % of the total channel depth and the local distortion of the front height h is small enough (|∇ h |<0.8 ) for the linear approximation to hold.

  20. Avalanche Segregation of Granular Media Poured into a Hele-Shaw Cell

    NASA Astrophysics Data System (ADS)

    Kakalios, J.; Koeppe, J.; Enz, M.

    1997-03-01

    When an initially homogeneous mixture of sand and sugar is poured into a "quasi-two-dimensional" Hele Shaw cell, that is, two vertical transparent plates held a narrow distance apart, the resulting pile forms alternating segregated layers (H. A. Makse, S. Havlin, P. B. King and H. E. Stanley, to be published.). We report studies of this "avalanche segregation" of granular mixtures as the plate separation and flow rates are systematically varied. The degree of segregation and wavelength are studied using digital images taken with a CCD camera and Fourier transformed to obtain the structure function of the banding pattern. As the plate separation is increased, for a given flow rate both the degree of segregation and wavelength (determined by the amplitude and position of the peak in the structure function) decreases. For intermediate plate separations, a pairing of adjacent segregated bands is observed. These results are discussed in terms of a recent model proposed by Boutreux and de Gennes (T. Boutreux and P.-G. de Gennes, J. Phys.I France 6, 1295 (1996)).

  1. New exact solutions for Hele-Shaw flow in doubly connected regions

    NASA Astrophysics Data System (ADS)

    Dallaston, Michael C.; McCue, Scott W.

    2012-05-01

    Radial Hele-Shaw flows are treated analytically using conformal mapping techniques. The geometry of interest has a doubly connected annular region of viscous fluid surrounding an inviscid bubble that is either expanding or contracting due to a pressure difference caused by injection or suction of the inviscid fluid. The zero-surface-tension problem is ill-posed for both bubble expansion and contraction, as both scenarios involve viscous fluid displacing inviscid fluid. Exact solutions are derived by tracking the location of singularities and critical points in the analytic continuation of the mapping function. We show that by treating the critical points, it is easy to observe finite-time blow-up, and the evolution equations may be written in exact form using complex residues. We present solutions that start with cusps on one interface and end with cusps on the other, as well as solutions that have the bubble contracting to a point. For the latter solutions, the bubble approaches an ellipse in shape at extinction.

  2. Interaction forces between microfluidic droplets in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Sarig, I.; Starosvetsky, Y.; Gat, A. D.

    2016-08-01

    Various microfluidic systems, such as chemical and biological lab-on-a-chip devices, involve motion of multiple droplets within an immersing fluid in shallow micro-channels. Modeling the dynamics of such systems requires calculation of the forces of interaction between the moving droplets. These forces are commonly approximated by superposition of dipoles solutions, which requires an assumption of sufficiently large distance between the droplets. In this work we obtain exact solutions (in the Hele-Shaw limit) for two moving droplets, and a droplet within a droplet, located within a moving immersing fluid, without limitation on the distance between the droplets. This is achieved by solution of the pressure field in a bi-polar coordinate system and calculation of the force in a Cartesian coordinate system. Our results are compared with numerical computations, experimental data and the existing dipole-based models. We utilize the results to calculate the dynamics of a droplet within a droplet, and of two close droplets, located within an immersing fluid with oscillating speed. The obtained results may be used to study the dynamics of dense droplet lattices, common to many microfluidic systems.

  3. Acceleration of convective dissolution by chemical reaction in a Hele-Shaw cell.

    PubMed

    Cherezov, Ilia; Cardoso, Silvana S S

    2016-09-14

    New laboratory experiments quantify the destabilising effect of a second-order chemical reaction on the fingering instability of a diffusive boundary layer in a Hele-Shaw cell. We show that, for a given chemical system, the dynamics of such a reactive boundary layer is fully determined by two dimensionless groups, Da/Ra(2), which measures the timescale for convection compared to those for reaction and diffusion, and CBo', which reflects the excess of the environmental reactant species relative to the diffusing solute. Results of a systematic study varying CBo' in the range 0-0.1 are presented. It is shown that the chemical reaction increases the growth rate of a perturbation and favours small wavelengths compared to the inert system. A higher concentration of CBo' not only accelerates the onset of convection, but crucially also increases the transport of the solute by up to 150% compared to the inert system. This increase in solute transfer has important practical implications, such as in the storage of carbon dioxide in saline aquifers.

  4. Labyrinthine instabilities of miscible magnetic fluids in a rotating Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Chen, Mei-Yu; Chen, Li-Que; Li, Huanhao; Wen, Chih-Yung

    2017-02-01

    This study presents the first experimental results of confining miscible magnetic fluids in a rotating Hele-Shaw cell. Variations in the prominence of labyrinthine instabilities are observed under a range of experimental conditions, with different magnetic field strengths, gap depths, and rotation speeds. These instabilities are characterized by two modified Péclect numbers, namely, Pem (the ratio of the characteristic magnetic advection rate and the diffusion rate) and Pec (the ratio of characteristic rotation advection and the diffusion rate). The magnetic effect is characterized by dipolar repulsion, which triggers a distinctive fingering pattern differing from the progressive diffusion pattern that occurs without magnetic fields or rotation. Under the same rotation speed, the magnetoviscous effect will hinder the growth rate of the magnetic drops at the later stage. However, both the rotation effect and the gap depth greatly enhance the growth rate of the magnetic drops, as these conditions help to intensify the labyrinthine instabilities. In contrast, the countering pressure gradient produces an opposite force that constrains the trend toward expansion. Two major phases in the growth of instabilities are defined: a magnetization phase and a rotation phase, which are dominated by the magnetic and the rotation effect, respectively. The significance of the rotation effect is confirmed by the linear regression between the rotation growth rate and Pec. Finally, main fingering structures that evolve from the secondary waves are verified as having a wavelength λ to gap depth h relation of λ ≈(7 ±1 ) h .

  5. Dynamics of viscous fingers in rotating Hele-Shaw cells with Coriolis effects.

    PubMed

    Gadêlha, Hermes; Brito, Nielison; Miranda, José A

    2007-01-01

    A growing number of experimental and theoretical works have been addressing various aspects of the viscous fingering formation in rotating Hele-Shaw cells. However, only a few of them consider the influence of Coriolis forces. The studies including Coriolis effects are mostly restricted to the high-viscosity-contrast limit and rely on either purely linear stability analyses or intensive numerical simulations. We approach the problem analytically and use a modified Darcy's law including the exact form of the Coriolis effects to execute a mode-coupling analysis of the system. By imposing no restrictions on the viscosity contrast A (dimensionless viscosity difference) we go beyond linear stages and examine the onset of nonlinearities. Our results indicate that when Coriolis effects are taken into account, an interesting interplay between the Reynolds number Re and A arises. This leads to important changes in the stability and morphological features of the emerging interfacial patterns. We contrast our mode-coupling approach with previous theoretical models proposed in the literature.

  6. Bubble dynamics inside an outgassing hydrogel confined in a Hele-Shaw cell.

    PubMed

    Haudin, Florence; Noblin, Xavier; Bouret, Yann; Argentina, Médéric; Raufaste, Christophe

    2016-08-01

    We report an experimental study of bubble dynamics in a non-Newtonian fluid subjected to a pressure decrease. The fluid is a hydrogel, composed of water and a synthetic clay, prepared and sandwiched between two glass plates in a Hele-Shaw geometry. The rheological properties of the material can be tuned by the clay concentration. As the imposed pressure decreases, the gas initially dissolved in the hydrogel triggers bubble formation. Different stages of the process are observed: bubble nucleation, growth, interaction, and creation of domains by bubble contact or coalescence. Initially bubble behave independently. They are trapped and advected by the mean deformation of the hydrogel, and the bubble growth is mainly driven by the diffusion of the dissolved gas through the hydrogel and its outgassing at the reactive-advected hydrogel-bubble interface. In this regime, the rheology of the fluid does not play a significant role on the bubble growth. A model is proposed and gives a simple scaling that relates the bubble growth rate and the imposed pressure. Carbon dioxide is shown to be the gas at play, and the hydrogel is degassing at the millimeter scale as a water solution does at a smaller scale. Later, bubbles are not independent anymore. The growth rate decreases, and the morphology becomes more anisotropic as bubbles interact because they are separated by a distance smaller than the individual stress field extension. Our measurements show that the interaction distance scales with the bubbles' size.

  7. Schlieren imaging of viscous fingering in a horizontal Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Bunton, P.; Marin, D.; Stewart, S.; Meiburg, E.; De Wit, A.

    2016-02-01

    Interfaces between different fluids can be unstable with regard to hydrodynamic instabilities such as viscous fingering or buoyancy-driven convection. To study such instabilities experimentally for transparent fluids, dyes or chemical indicators are most often used to track the dynamics. While the interfacial deformation can easily be tracked by color changes, it is difficult to have access to the internal flow structure for comparison with theoretical predictions. To overcome this problem, a modification of a Schlieren technique is introduced to image 3D flows during viscously driven instabilities in a horizontal Hele-Shaw cell without using any dye or chemical indicator. The method is exquisitely sensitive, readily yielding information about 3D flows in gaps under a millimeter and allowing imaging of the flow structure internal to the fingers, rather than merely imaging the flow boundary. Following a description of the technique, visualization of dynamics for nonreactive water-glycerol and reactive displacements is presented revealing previously unobserved internal flows. These flows are tentatively interpreted in terms of known theoretical predictions.

  8. A novel depot preparation of desferrioxamine-B: development of formulation principles.

    PubMed

    Lowther, N; Sparks, K; Nicklin, J; Jin, Y

    1999-11-01

    This report describes the feasibility of simple oil-based depot formulations of a novel n-decanesulfonate salt of the iron chelator desferrioxamine-B. After subcutaneous administration in rodents, desferrioxamine-B n-decanesulfonate depot induces both (a) prolonged release of drug and (b) an increase of at least threefold to fourfold in iron excretion efficiency compared with the parent compound Desferal (desferrioxamine-B mesylate). Optimization experiments probing vehicle composition, surfactant loading, drug loading, and particle size distribution of the depot preparation are described, and the physiochemical stability of an identified pilot formulation is assessed.

  9. Epicardial adipose tissue: far more than a fat depot

    PubMed Central

    Talman, Andrew H.; Psaltis, Peter J.; Cameron, James D.; Meredith, Ian T.; Seneviratne, Sujith K.

    2014-01-01

    Epicardial adipose tissue (EAT) refers to the fat depot that exists on the surface of the myocardium and is contained entirely beneath the pericardium, thus surrounding and in direct contact with the major coronary arteries and their branches. EAT is a biologically active organ that may play a role in the association between obesity and coronary artery disease (CAD). Given recent advances in non-invasive imaging modalities such a multidetector computed tomography (MDCT), EAT can be accurately measured and quantified. In this review, we focus on the evidence suggesting a role for EAT as a quantifiable risk marker in CAD, as well as describe the role EAT may play in the development and vulnerability of coronary artery plaque. PMID:25610800

  10. Sex dimorphism and depot differences in adipose tissue function

    PubMed Central

    White, Ursula A.; Tchoukalova, Yourka D.

    2013-01-01

    Obesity, characterized by excessive adiposity, is a risk factor for many metabolic pathologies, such as Type 2 Diabetes mellitus (T2DM). Numerous studies have shown that adipose tissue distribution may be a greater predictor of metabolic health. Upper-body fat (visceral and subcutaneous abdominal) is commonly associated with the unfavorable complications of obesity, while lower-body fat (gluteal-femoral) may be protective. Current research investigations are focused on analyzing the metabolic properties of adipose tissue, in order to better understand the mechanisms that regulate fat distribution in both men and women. This review will highlight the adipose tissue depot- and sex- dependent differences in white adipose tissue function, including adipogenesis, adipose tissue developmental patterning, the storage and release of fatty acids, and secretory function. PMID:23684841

  11. Couches Minces de Titanate de Baryum Par Depot Organometallique

    NASA Astrophysics Data System (ADS)

    Ousi Benomar, Wahib

    1993-01-01

    Nous avons demontre la possibilite de realiser des couches minces de titanate de baryum par depot organometallique. Les films sont obtenus apres dissolution d'organometalliques choisis dans un solvant et une cuisson a une temperature determinee par thermogravimetrie. Apres un second traitement thermique a des temperatures plus elevees, les echantillons presentent une structure polycristalline tetragonale; les cristallites sont observes par microscopie electronique a balayage. La mesure de la constante dielectrique a permis de mettre en evidence une transition de phase de la structure tetragonale a la structure cubique a une temperature d'environ 125^circC. Les mesures d'indice ont ete effectuees. On note une augmentation de l'indice de refraction des films avec la temperature indiquant une meilleure densification des films. Nous avons aussi montre qu'il etait possible d'utiliser ce materiau en tant que guide d'onde optique pour pouvoir exploiter ses proprietes electrooptiques dans l'avenir.

  12. [Conditions for blood components return, after storage in a depot].

    PubMed

    Hervé, I; Girard, A

    2008-11-01

    Recent changes in the regulation of blood components depots has allowed the Etablissement français du sang (EFS) to re-introduce blood components in the stock when they come back from the health establishment. This process is the responsibility of both EFS and health establishment. So collaboration between them is necessary to set an organisation to guarantee that blood components are transported and stored at optimum conditions. To achieve this, a checking procedure for the return process of blood components and a method that tracks the conditions they are exposed to during transportation are necessary. There are many temperature sensitive indicators available to track each unit of blood component. This article presents an organisation using a follow-up by electronic temperature monitors to record the temperature during the transportation and storage processes.

  13. Depot medroxyprogesterone acetate contraception in women with medical problems.

    PubMed

    Frederiksen, M C

    1996-05-01

    Since few clinical trials of contraceptive agents are conducted on women with medical problems, use of these agents in these populations is often based more upon theoretical considerations than clinical data. Clinicians must distinguish the risk of estrogen in the combined oral contraceptive from the risk of the progestin-only contraceptive methods. This review compares the risks of pregnancy with the risks of contraceptive methods for patients with chronic hypertension, cardiac disease, thrombotic disorders, diabetes, epilepsy, lupus erythematosus and other medical disorders. For women with certain medical problems, estrogen, but not progestogen, may be contraindicated. For these women, a long-acting progestogen, such as depot medroxyprogesterone acetate (DMPA), may offer distinct advantages.

  14. Invasive cervical cancer and depot-medroxyprogesterone acetate

    PubMed Central

    1985-01-01

    Preliminary results of a study of the possible relationship of depot-medroxy-progesterone acetate (DMPA) to invasive cervical cancer are presented. The findings are based on data from three participating centres in Thailand and one in Mexico. A relative risk for cervical cancer of 1.2 was observed in women who had ever used DMPA; this was not statistically significant. No consistent increase in risk with duration of use was observed, although a relative risk of 2 was found in women who had used DMPA for more than 5 years. This observed increase in risk was confined to women who were aged under 46 years or who had first been exposed to DMPA before 30 years of age. These findings are based on small numbers of subjects, and may not represent a causal relationship. PMID:2931205

  15. The genetics of brown adipocyte induction in white fat depots.

    PubMed

    Kozak, Leslie P

    2011-01-01

    Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription factor that stimulate the induction of brown adipocytes has come from transgenic and gene KO models. However, these models have created a very complex picture of the regulatory mechanisms for brown fat induction. In this review insights into the critical regulatory pathways involved in brown adipocyte induction in the retroperitoneal fat depot of mice are described from quantitative trait locus (QTL) analysis of allelic variability determining Ucp1 levels and brown adipocyte induction in A/J vs. B6 mice. The key observation is that recombinant genotypes, found in recombinant inbred stains and backcross and intercross progeny, show transgressive variation for Ucp1 mRNA levels. These genetic crosses also show that the levels of Ucp1 mRNA are determined by interactions that control the levels of PPARα, PGC-1α, and type 2 deiodinase (DIO2) and that each factor is controlled by a subset of QTLs that also control Ucp1 expression. These results indicate that induction of Ucp1 in the retroperitoneal fat depot involves synergy between signaling and transcription factors that vary depending upon the environmental conditions. Inherent in this model is the idea that there is a high level of redundancy that can involve any factor with the potential to influence expression of the core factors, PPARα, PGC-1a, and DIO2.

  16. U.S. Naval Base, Pearl Harbor, Naval Ammunition Depot West Loch, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    U.S. Naval Base, Pearl Harbor, Naval Ammunition Depot West Loch, Oahu, Dispensary, Near Avenue A between First & Second Streets, Lualualei, West Loch Branch Naval Magazine, Pearl City, Honolulu County, HI

  17. Drilling and testing of well 340, Fort Wingate Army Depot, McKinley County, New Mexico

    USGS Publications Warehouse

    Shomaker, John W.

    1969-01-01

    The U.S. Geological Survey was requested by Fort Wingate Army Depot to designate a well location, suggest construction and testing procedures, and provide continuing technical advice with respect to the drilling of a new production well. The location was determined during a brief preliminary study of the Depot's water supply which is summarized in a report transmitted to the Depot in April of 1968, and the Geological Survey's suggestions for construction and testing are contained in the specifications written by the Post Engineer at the Depot as part of the well-drilling contract. A representative of the the Geological Survey was present during most of the drilling and testing of the well.

  18. Forward-looking recognition based on convex hull invariants of oil depot region

    NASA Astrophysics Data System (ADS)

    He, Fangfang; Sun, Jiyin; Han, Bing; Xia, Jing

    2007-11-01

    Forward-looking navigation system is a fire-new technique for terminal guidance of intending precision-guided weapons and research on oil depot recognition of forward-looking imaging is an essential task for this control and guide system. As conventional matching methods could not overcome perspective transmutation, a new method to identify the forward-looking area of oil depot was advanced in this paper. First, constructed three statistics of regions based on convex hull, which were invariant to affine transform. Then, number of inside oilcans could easily be achieved by adding a decision step. Finally the area of oil depot could be located according to the comparison between the computed number and the foreknowable number under a given threshold. Experiments applied to optical images in different areas show that the proposed method is accurate and has wider application in identifying such small objects as oilcans, and it realizes automatically recognizing area of oil depot from forward-looking imaging.

  19. Depot Dependent Effects of Dexamethasone on Gene Expression in Human Omental and Abdominal Subcutaneous Adipose Tissues from Obese Women

    PubMed Central

    Karastergiou, Kalypso; Gower, Adam; Fried, Susan K.

    2016-01-01

    Glucocorticoids promote fat accumulation in visceral compared to subcutaneous depots, but the molecular mechanisms involved remain poorly understood. To identify long-term changes in gene expression that are differentially sensitive or responsive to glucocorticoids in these depots, paired samples of human omental (Om) and abdominal subcutaneous (Abdsc) adipose tissues obtained from obese women during elective surgery were cultured with the glucocorticoid receptor agonist dexamethasone (Dex, 0, 1, 10, 25 and 1000 nM) for 7 days. Dex regulated 32% of the 19,741 genes on the array, while 53% differed by Depot and 2.5% exhibited a Depot*Dex concentration interaction. Gene set enrichment analysis showed Dex regulation of the expected metabolic and inflammatory pathways in both depots. Cluster analysis of the 460 transcripts that exhibited an interaction of Depot and Dex concentration revealed sets of mRNAs for which the responses to Dex differed in magnitude, sensitivity or direction between the two depots as well as mRNAs that responded to Dex only in one depot. These transcripts were also clearly depot different in fresh adipose tissue and are implicated in processes that could affect adipose tissue distribution or functions (e.g. adipogenesis, triacylglycerol synthesis and storage, insulin action). Elucidation of the mechanisms underlying the depot differences in the effect of Dex on the expression of specific genes and pathways that regulate adipose function may offer novel insights into understanding the biology of visceral adipose tissues and their links to metabolic health. PMID:28005982

  20. Depot Dependent Effects of Dexamethasone on Gene Expression in Human Omental and Abdominal Subcutaneous Adipose Tissues from Obese Women.

    PubMed

    Pickering, R Taylor; Lee, Mi-Jeong; Karastergiou, Kalypso; Gower, Adam; Fried, Susan K

    2016-01-01

    Glucocorticoids promote fat accumulation in visceral compared to subcutaneous depots, but the molecular mechanisms involved remain poorly understood. To identify long-term changes in gene expression that are differentially sensitive or responsive to glucocorticoids in these depots, paired samples of human omental (Om) and abdominal subcutaneous (Abdsc) adipose tissues obtained from obese women during elective surgery were cultured with the glucocorticoid receptor agonist dexamethasone (Dex, 0, 1, 10, 25 and 1000 nM) for 7 days. Dex regulated 32% of the 19,741 genes on the array, while 53% differed by Depot and 2.5% exhibited a Depot*Dex concentration interaction. Gene set enrichment analysis showed Dex regulation of the expected metabolic and inflammatory pathways in both depots. Cluster analysis of the 460 transcripts that exhibited an interaction of Depot and Dex concentration revealed sets of mRNAs for which the responses to Dex differed in magnitude, sensitivity or direction between the two depots as well as mRNAs that responded to Dex only in one depot. These transcripts were also clearly depot different in fresh adipose tissue and are implicated in processes that could affect adipose tissue distribution or functions (e.g. adipogenesis, triacylglycerol synthesis and storage, insulin action). Elucidation of the mechanisms underlying the depot differences in the effect of Dex on the expression of specific genes and pathways that regulate adipose function may offer novel insights into understanding the biology of visceral adipose tissues and their links to metabolic health.

  1. Gravitational instability due to the dissolution of carbon dioxide in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Vreme, A.; Nadal, F.; Pouligny, B.; Jeandet, P.; Liger-Belair, G.; Meunier, P.

    2016-10-01

    We present an experimental study of the gravitational instability triggered by dissolution of carbon dioxide through a water-gas interface. We restrict the study to vertical parallelepipedic Hele-Shaw geometries, for which the thickness is smaller than the other dimensions. The partial pressure of carbon dioxide is quickly increased, leading to a denser layer of CO2-enriched water underneath the surface. This initially one-dimensional diffusive layer destabilizes through a convection-diffusion process. The concentration field of carbon dioxide, which is visualized by means of a pH-sensitive dye, shows a fingering pattern whose characteristics (wavelength and amplitude growth rate) are functions of the Rayleigh (Ra) and the Darcy (Da) numbers. At low Rayleigh numbers, the growth rate and the wave numbers are independent of the Rayleigh number and in excellent agreement with the classical results obtained numerically and theoretically in the Darcy regime. However, above a threshold of Ra√{Da} of the order of 10, the growth rate and the wave number strongly decrease due to the Brinkman term associated with the viscous diffusion in the vertical and longitudinal directions. In this Darcy-Brinkman regime, the growth rate and the wave number depend only on the thickness-based Rayleigh number Ra√{Da} . The classical Rayleigh-Taylor theory including the Brinkman term has been extended to this diffusive gravitational instability and gives an excellent prediction of the growth rate over four decades of Rayleigh numbers. However, the Brinkman regime seems to be valid only until Ra√{Da}=1000 . Above this threshold, the transverse velocity profile is no longer parabolic, which leads to an overestimation of the wave number by the theory.

  2. Double-Diffusive Finger Convection: Flow Field Evolution in a Hele-Shaw Cell

    SciTech Connect

    COOPER,CLAY A.; GLASS JR.,ROBERT J.; TYLER,SCOTT W.

    2000-12-21

    Double-diffusive finger convection is a hydrodynamic instability that can occur when two components with different diffusivities are oppositely stratified with respect to the fluid density gradient as a critical condition is exceeded. Laboratory experiments were designed using sodium chloride and sucrose solutions in a Hele-Shaw cell. A high resolution, full field, light transmission technique was used to study the development of the instability. The initial buoyancy ratio (R{sub p}), which is a ratio of fluid density contributions by the two solutes, was varied systematically in the experiments so that the range of parameter space spanned conditions that were nearly stable (R{sub p} = 2.8) to those that were moderately unstable (R{sub p} = 1.4). In systems of low R{sub p}, fingers develop within several minutes, merge with adjacent fingers, form conduits, and stall before newer-generated fingers travel through the conduits and continue the process. Solute fluxes in low R{sub p} systems quickly reach steady state and are on the order of 10{sup {minus}6} m{sup 2} sec{sup {minus}1}. In the higher R{sub p} experiments, fingers are slower to evolve and do not interact as dynamically as in the lower R{sub p} systems. Our experiment with initial R{sub p} = 2.8 exhibited flux on the order of that expected for a similar diffusive system (i.e., 10{sup {minus}7} m{sup 2} sec{sup {minus}1}), although the structures were very different than the pattern of transport expected in a diffusing system. Mass flux decayed as t{sup 1/2} in two experiments each with initial R{sub p} = 2.4 and 2.8.

  3. Time dependence and local structure of tracer dispersion in oscillating liquid Hele-Shaw flows

    NASA Astrophysics Data System (ADS)

    Roht, Y. L.; Auradou, H.; Hulin, J.-P.; Salin, D.; Chertcoff, R.; Ippolito, I.

    2015-10-01

    Passive tracer dispersion in oscillating Poiseuille liquid flows of zero net velocity is studied experimentally in a Hele-Shaw cell and numerically by 2D simulations: this study is particularly focused on the time dependence and local properties of the dispersion. The dispersion mechanism is found to be controlled by the ratio τm/T of the molecular diffusion time across the gap and the oscillation period (when molecular diffusion parallel to the flow is negligible). The 2D numerical simulations complement the experiments by providing the local concentration c(x, z, t) at a given distance z from the cell walls (instead of only the average over z). Above a time lapse scaling like τm, the variation of c with the distance x along the flow becomes a Gaussian of width constant with z while the mean distance x ¯ may depend both on z and t. For τm/T ≲ 2, the front spreads through Taylor-like dispersion and the normalized dispersivity scales as τm/T. The front oscillates parallel to the flow with an amplitude constant across the gap; its width increases monotonically at a rate modulated at twice the flow frequency, due to variations of the instantaneous dispersivity. For τm/T ≳ 20, the molecular diffusion distance during a period of the flow is smaller than the gap and the normalized dispersivity scales as (τm/T)-1. The oscillations of the different points of the front follow the local fluid velocity: this produces a reversible modulation of the global front width at twice the flow frequency and in quadrature with that in the Taylor-like regime.

  4. Stability results for multi-layer radial Hele-Shaw and porous media flows

    NASA Astrophysics Data System (ADS)

    Gin, Craig; Daripa, Prabir

    2015-01-01

    Motivated by stability problems arising in the context of chemical enhanced oil recovery, we perform linear stability analysis of Hele-Shaw and porous media flows in radial geometry involving an arbitrary number of immiscible fluids. Key stability results obtained and their relevance to the stabilization of fingering instability are discussed. Some of the key results, among many others, are (i) absolute upper bounds on the growth rate in terms of the problem data; (ii) validation of these upper bound results against exact computation for the case of three-layer flows; (iii) stability enhancing injection policies; (iv) asymptotic limits that reduce these radial flow results to similar results for rectilinear flows; and (v) the stabilizing effect of curvature of the interfaces. Multi-layer radial flows have been found to have the following additional distinguishing features in comparison to rectilinear flows: (i) very long waves, some of which can be physically meaningful, are stable; and (ii) eigenvalues can be complex for some waves depending on the problem data, implying that the dispersion curves for one or more waves can contact each other. Similar to the rectilinear case, these results can be useful in providing insight into the interfacial instability transfer mechanism as the problem data are varied. Moreover, these can be useful in devising smart injection policies as well as controlling the complexity of the long-term dynamics when drops of various immiscible fluids intersperse among each other. As an application of the upper bound results, we provide stabilization criteria and design an almost stable multi-layer system by adding many layers of fluid with small positive jumps in viscosity in the direction of the basic flow.

  5. RCRA facility investigation. Phase 1. Summary report for known releases units, Tooele Army Depot, South Area. Final report, August 1989-March 1990

    SciTech Connect

    Gers, J.; Harris, V.A.; Merino, J.M.

    1990-03-27

    An RFI Phase I Summary Report was prepared to summarize information regarding solid waste management units (SWMU)s with known releases at the Tooele Army Depot-South Area in Utah. These SWMUs are the Chemical Agent Munitions Disposal System (CAMDS), and the area in the vicinity of the inactive Deactivation Furnace. CAMDS is designed to treat new equipment for demilitarizing many different types of chemical munitions. Waste and product spills have been noted at CAMDS; these include releases at the boiler blowdown ditch and ponding area, the three diesel oil above-ground tanks, and the underground fuel oil product lines. The inactive deactivation furnace served as a prototype of the CAMDS facility by disposing of fuses, first-fire mixes, primers, and small arms. A mercury spill and fuel oil spill were reported to have occurred in this area. Environmental impacts due to the reported spills are summarized in the report.

  6. Depot Maintenance: Management Attention Required to Further Improve Workload Allocation Data

    DTIC Science & Technology

    2001-11-01

    Report to Congressional Committees United States General Accounting Office GAO November 2001 DEPOT MAINTENANCE Management Attention Required to...Title and Subtitle DEPOT MAINTENANCE: Management Attention Required to Further Improve Workload Allocation Data Contract Number Grant Number Program...part of our work, we also examined the DOD’s efforts to improve the reporting process and sought to identify opportunities to further improve it. To

  7. Disposal of chemical agents and munitions stored at Anniston Army Depot, Anniston, Alabama

    SciTech Connect

    Hunsaker, D.B. Jr.; Zimmerman, G.P.; Staub, W.P.; Hillsman, E.L.

    1990-09-01

    This is the 1990 Addendum (Volume 2) for the Phase I report on the disposal of chemicals and munitions at Anniston Army Depot. Included in the Addendum are responses to reviewers' comments on population density estimates, seismicity information, fault locations, and references. Reviewing agencies errata, and conclusions are also listed. Information presented does not change the principal conclusion reached by the Phase I report, that on-site disposal remains valid for Anniston Army Depot. (SM)

  8. Ten year outcomes of outpatients with schizophrenia on conventional depot antipsychotics: a systematic chart review.

    PubMed

    Uchida, Takahito; Suzuki, Takefumi; Sakurai, Hitoshi; Tsutsumi, Chisa; Den, Ryosuke; Mimura, Masaru; Uchida, Hiroyuki

    2013-09-01

    Long-term follow-up data of patients with schizophrenia on depot antipsychotics have been few and the longest follow-up period has been up to 7 years. We carried out a systematic chart review to examine 10-year outcomes for outpatients with schizophrenia who were receiving a conventional depot antipsychotic. Maintenance of outpatient status for 10 years was considered as a favorable outcome. From the initial sample of 1587 outpatients, 90 patients who were receiving a depot antipsychotic were included in this study (mean±SD, age 44.0±13.0 years; men, N=54). Haloperidol decanoate, fluphenazine decanoate, fluphenazine enanthate, and haloperidol decanoate plus fluphenazine enanthate were used in 53 (58.9%), 29 (32.2%), seven (7.8%), and one (1.1%) patients, respectively. These depot antipsychotics accounted for 36.9% of the total antipsychotic dosage on average. Seventeen patients (18.9%) successfully maintained outpatient status for 10 years. The most frequent reason for dropout was 'hospitalization' (N=49, 54.4%), followed by 'referral to another clinic/hospital' (N=9, 10.0%) and 'side effects' (N=7, 7.8%). As only 36.9% of the chlorpromazine equivalents were administered through depot antipsychotics, it is difficult to draw any firm conclusion. Still, the data suggest that even depot antipsychotics may not sufficiently prevent relapse in the treatment of schizophrenia.

  9. Fingering patterns in Hele-Shaw flows are density shock wave solutions of dispersionless KdV hierarchy

    SciTech Connect

    Teodorescu, Razvan; Lee, S - Y; Wiegmann, P

    2008-01-01

    We investigate the hydrodynamics of a Hele-Shaw flow as the free boundary evolves from smooth initial conditions into a generic cusp singularity (of local geometry type x{sup 3} {approx} y{sup 2}), and then into a density shock wave. This novel solution preserves the integrability of the dynamics and, unlike all the weak solutions proposed previously, is not underdetermined. The evolution of the shock is such that the net vorticity remains zero, as before the critical time, and the shock can be interpreted as a singular line distribution of fluid deficit.

  10. Droplet relaxation in Hele-Shaw geometry: Application to the measurement of the nematic-isotropic surface tension

    NASA Astrophysics Data System (ADS)

    Oswald, Patrick; Poy, Guilhem

    2015-12-01

    Shape measurements after the coalescence of isotropic droplets embedded in a thin sample of a homeotropic nematic phase provides a tool to measure the nematic-isotropic surface tension. In addition, this experiment allows us to check the scaling laws recently given by Brun et al. [P.-T. Brun, M. Nagel, and F. Gallaire, Phys. Rev. E 88, 043009 (2013), 10.1103/PhysRevE.88.043009] to explain the relaxation of ellipsoidal droplets in a Hele-Shaw cell.

  11. Effects of circular rigid boundaries and Coriolis forces on the interfacial instability in a rotating annular Hele-Shaw cell.

    PubMed

    Abidate, Asmaa; Aniss, Said; Caballina, Ophélie; Souhar, Mohamed

    2007-04-01

    We report analytical results for the development of instability of an interface between two immiscible, Newtonian fluid layers confined in a rotating annular Hele-Shaw cell. We perform a linear stability analysis and focus our study on the influence of both Coriolis force and curvature parameters on the interface instability growth rate. The results show that the Coriolis force does not alter the stability of a disturbance with a particular wave number but reduces the maximum growth rate. The results related to the role played by the confinement of the liquid layers are also shown to provide a modification of the fastest-growing mode and its corresponding linear growth rate.

  12. Seismo-acoustic analysis of the Buncefield oil depot explosion in the UK, 2005 December 11

    NASA Astrophysics Data System (ADS)

    Ottemöller, L.; Evers, L. G.

    2008-03-01

    A massive vapour cloud explosion occurred at the Buncefield fuel depot near Hemel Hempstead, UK, in the morning of 2005 December 11. The explosion was the result of an overflow from one of the storage tanks with the release of over 300 tons of petrol and generating a vapour cloud that spread over an area of 80000 m2, before being ignited. Considerable damage was caused in the vicinity of the explosion and a total of 43 people were injured. The explosion was detected by seismograph stations in the UK and the Netherlands and by infrasound arrays in the Netherlands. We analysed the seismic recordings to determine the origin time of 06:01:31.45 +/-0.5 s (UTC) from P-wave arrival times. Uncertainties in determination of origin time from acoustic arrival times alone were less than 10 s. Amplitudes of P-, Lg and primary acoustic waves were measured to derive decay relationships as function of distance. From the seismic amplitudes we estimated a yield of 2-10 tons equivalent to a buried explosion. Most seismic stations recorded primary and secondary acoustic waves. We used atmospheric ray tracing to identify the various travel paths, which depend on temperature and wind speed as function of altitude, leading to directional variation. Refracted waves were observed from the troposphere, stratosphere and thermosphere with a good match between observed and calculated traveltimes. The various wave types were also identified through array processing, which provides backazimuth and slowness, of recordings from an infrasound array in the Netherlands. The amplitude of stratospheric refracted acoustic waves recorded by the array microbarometers was used to estimate a yield of 21.6 (+/-5) tons TNT equivalent. We have demonstrated through joint seismo-acoustic analysis of the explosion that both the seismic velocity model and the atmospheric model are sufficient to explain the observed traveltimes.

  13. Design and Fabrication of a Hele-Shaw Apparatus for Observing Instabilities of Diffusion Flames

    NASA Technical Reports Server (NTRS)

    Wichman, I. S.; Oravecz-Simpkins, L.; Olson, S.

    2001-01-01

    Examinations of flame fronts spreading over solid fuels in an opposed flow of oxidizer have shown that the flame front fragments into smaller (cellular) flames. These 'flamelets' will oscillate, recombine, or extinguish, indicating that they are in the near extinction limit regime (i.e., to one side of the quenching branch of the flammability map). Onset of unstable cellular flamelet formation for flame spread over thin fuels occurs when a heat-sink substrate is placed a small distance from the underside of the fuel. This heat-sink substrate (or backing) displaces the quenching branch of the flammability map in a direction that causes the instabilities to occur at higher air velocities. Similar near-limit behavior has been observed in other works using different fuels, thus suggesting that these dynamic mechanisms are fuel-independent and therefore fundamental attributes of flames in this near-limit flame spread regime. The objective of this project is to determine the contributions of the hydrodynamic and thermodiffusive mechanisms to the observed formation of flame instabilities. From this, a model of diffusion flame instabilities shall be generated. Previously, experiments were conducted in NASA drop towers, thereby limiting observation time to O(1-5 sec). The NASA tests exhibited flamelet survival for the entire drop time, suggesting that flamelets (i.e., small cellular flames) might exist, if permitted, for longer time periods. By necessity, experiments were limited to thermally thin cellulose fuels (approximately 0.001 in thick): instabilities could form by virtue of faster spread rates over thin fuels. Unstable behavior was unlikely in the short drop time for thicker fuels. In the International Space Station (ISS), microgravity time is unlimited, so both thin and thick fuels can be tested.

  14. National Fuel Cell Bus Program: Accelerated Testing Evaluation Report #2, Alameda-Contra Costa Transit District (AC Transit) and Appendices

    SciTech Connect

    Eudy, L.; Chandler, K.

    2010-06-01

    This is an evaluation of hydrogen fuel cell transit buses operating at AC Transit in revenue service since March 20, 2006, comparing similar diesel buses operating from the same depot. It covers November 2007 through February 2010. Results include implementation experience, fueling station operation, evaluation results at AC Transit (bus usage, availability, fuel economy, maintenance costs, and road calls), and a summary of achievements and challenges encountered during the demonstration.

  15. Optimisation of microstructured biodegradable finasteride formulation for depot parenteral application.

    PubMed

    Ahmed, Osama A; Hussein, Amal K; Mady, Fatma M

    2016-05-01

    This study aimed to use the biocompatibility features of the biodegradable polymers to prepare depot injectable finasteride (FIN) microspheres for the treatment of benign prostatic hyperplasia. FIN microspheres were prepared utilising an emulsion-solvent evaporation/extraction technique. The Box-Behnken experimental design was adopted to optimise the preparation process. FIN plasma levels in albino rabbits were determined after injection with optimised FIN microspheres formula and compared with oral FIN suspension. Results revealed that the optimum microspheres displayed an amended sustained release pattern with lower initial burst. The cumulative FIN % released after 25 days was in the range 27.83-73.18% for F4 and F1, respectively. The optimised formula, with 50.0% (X1), and 22.316% (X2) and 1.38% (X3) showed 6.503 μm, 93.213%, 14.574%, and 64.838% for Y1, Y2, Y3, and Y4, respectively. In vivo studies displayed a sustained release pattern with minimal initial burst release when injected into rabbits.

  16. Performance Gains of Propellant Management Devices for Liquid Hydrogen Depots

    NASA Technical Reports Server (NTRS)

    Hartwig, Jason W.; McQuillen, John B.; Chato, David J.

    2013-01-01

    This paper presents background, experimental design, and preliminary experimental results for the liquid hydrogen bubble point tests conducted at the Cryogenic Components Cell 7 facility at the NASA Glenn Research Center in Cleveland, Ohio. The purpose of the test series was to investigate the parameters that affect liquid acquisition device (LAD) performance in a liquid hydrogen (LH2) propellant tank, to mitigate risk in the final design of the LAD for the Cryogenic Propellant Storage and Transfer Technology Demonstration Mission, and to provide insight into optimal LAD operation for future LH2 depots. Preliminary test results show an increase in performance and screen retention over the low reference LH2 bubble point value for a 325 2300 screen in three separate ways, thus improving fundamental LH2 LAD performance. By using a finer mesh screen, operating at a colder liquid temperature, and pressurizing with a noncondensible pressurant gas, a significant increase in margin is achieved in bubble point pressure for LH2 screen channel LADs.

  17. Emergency response concept plan for Anniston Army Depot and vicinity

    SciTech Connect

    Carnes, S.A.; Sorensen, J.H.; Rogers, G.O.; Shumpert, B.L.; Miller, R.L.; Watson, A.P.; Chester, C.V.

    1989-10-01

    The continued storage and disposal of the United States' unitary chemical stockpile, including that portion stored at Anniston Army Depot (ANAD) near Anniston, Alabama, have the potential for accidental releases that could escape installation boundaries and pose a threat to civilian populations. The US Army, in conjunction with the Federal Emergency Management Agency and other federal agencies, is committed to implement an emergency preparedness program that will significantly reduce the probability of adverse effects from such releases. This concept plan, which is but a part of a comprehensive ongoing effort, provides a framework for initiating such a program for the UMDA stockpile. This report develops information and methodologies that bear on two major decisions for such a program -- determining emergency planning zones and selecting protective action strategies. These decisions are based on the hazards posed by the UMDA stockpile and its disposal. These hazards, in turn, are based largely on the distribution of potential accidental releases associated with interim storage and disposal activities and associated external events (e.g., earthquakes and airplane crashes), the distribution of natural features that can affect an agent release (topographical features and meteorological characteristics), and the distribution of people and resources (e.g., homes, schools, and hospitals) potentially affected by an accidental release. 25 refs., 9 figs., 13 tabs.

  18. Depot risperidone-induced adverse metabolic alterations in female rats.

    PubMed

    Horska, Katerina; Ruda-Kucerova, Jana; Karpisek, Michal; Suchy, Pavel; Opatrilova, Radka; Kotolova, Hana

    2017-04-01

    Atypical antipsychotics are associated with adverse metabolic effects including weight gain, increased adiposity, dyslipidaemia, alterations in glucose metabolism and insulin resistance. Increasing evidence suggests that metabolic dysregulation precedes weight gain development. The aim of this study was to evaluate alterations in adipokines, hormones and basic serum biochemical parameters induced by chronic treatment with depot risperidone at two doses (20 and 40 mg/kg) in female Sprague-Dawley rats. Dose-dependent metabolic alterations induced by risperidone after 6 weeks of treatment were revealed. Concomitant to weight gain and increased liver weight, an adverse lipid profile with an elevated triglyceride level was observed in the high exposure group, administered a 40 mg/kg dose repeatedly, while the low dose exposure group, administered a 20 mg/kg dose, developed weight gain without alterations in the lipid profile and adipokine levels. An initial peak in leptin serum level after the higher dose was observed in the absence of weight gain. This finding may indicate that the metabolic alterations observed in this study are not consequent to body weight gain. Taken together, these data may support the primary effects of atypical antipsychotics on peripheral tissues.

  19. Depot medroxyprogesterone (Depo-Provera) and risk of breast cancer.

    PubMed Central

    Paul, C.; Skegg, D. C.; Spears, G. F.

    1989-01-01

    OBJECTIVE--To determine whether use of the injectable contraceptive depot medroxyprogesterone acetate (Depo-Provera) affects the risk of breast cancer in women. DESIGN--A population based case-control study. SETTING--Nationwide community study. SUBJECTS--891 Women aged 25-54 with newly diagnosed breast cancer were compared with 1864 women selected at random from the electoral rolls. INTERVENTION--Women were interviewed by telephone about past use of contraceptives and about possible risk factors for breast cancer. MAIN OUTCOME MEASURE--Relative risk of breast cancer in women who had used medroxyprogesterone. RESULTS--Medroxyprogesterone had been used by 110 patients and 252 controls. Overall, the relative risk of breast cancer associated with any duration of use was 1.0 (95% confidence interval 0.80 to 1.3). In women aged 25-34 the relative risk was 2.0 (1.0 to 3.8). The relative risk was highest in women aged 25-34 who had used the drug for six years or longer, although there were few women in this category. Women who had used it for two years or longer before age 25 had an increased risk of breast cancer (relative risk 4.6; 1.4 to 15.1). CONCLUSION--Despite the lack of an overall association these findings suggest that medroxyprogesterone may increase the risk of breast cancer in young women. PMID:2529939

  20. Waves on a Hele-Shaw Cell: Simulations of Acoustic Emissions During Aerofracture

    NASA Astrophysics Data System (ADS)

    Turkaya, Semih; Toussaint, Renaud; Kvalheim Eriksen, Fredrik; Daniel, Guillaume; Grude Flekkøy, Eirik; Jørgen Måløy, Knut

    2016-04-01

    In this work, we develop a numerical model to explain the lab scale experimental setup [1] modeling the aerofractures in a porous medium. The mentioned experimental setup consists in a rectangular Hele-Shaw cell with three closed boundaries and one semi-permeable boundary which enables the flow of the fluid but not the solid particles. During the experiments, the fluid (pressurized air) is injected into the system with a constant injection pressure from the point opposite to the semi-permeable boundary. At the large enough injection pressures, the fluid also displaces grains (80 μm grain size) and creates channels and fractures towards the semi-permeable boundary. This analogue model is developed in a linear geometry, with confinement and at a lower porosity to study the instabilities developing during the fast motion of a fluid in dense porous materials: fracturing, fingering, and channeling. Different sources of the signal (air vibration in the carved area, changes in the effective stress due to fluid-solid interactions [2]) are separately analyzed and are investigated further using a far field approximation of Lamb waves presented by Goyder & White [3]. In the analysis phase, power spectrum of different timewindows (5 ms) obtained from the recorded signal are computed. Then, the evolution of this power spectrum is compared with the experimental findings. In the power spectrum, it is possible to see some characteristic structure like peaks in specific frequency ranges. These "peaks" are strongly influenced by the size and branching of the channels, compaction of the medium, vibration of air in the pores and the fundamental frequency of the plate. We found that, in the synthetic dataset, the peaks in the low frequency range (f < 20 kHz) diminishes while the medium fractures as suggested in experimental work. 1. Turkaya S, Toussaint R, Eriksen FK, Zecevic M, Daniel G, Flekkøy EG, Måløy KJ. "Bridging aero-fracture evolution with the characteristics of the

  1. Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation.

    PubMed

    Lee, Jane J; Britton, Kathryn A; Pedley, Alison; Massaro, Joseph M; Speliotes, Elizabeth K; Murabito, Joanne M; Hoffmann, Udo; Ingram, Cheryl; Keaney, John F; Vasan, Ramachandran S; Fox, Caroline S

    2016-05-04

    Visceral adipose tissue (VAT) and fatty liver differ in their associations with cardiovascular risk compared with subcutaneous adipose tissue (SAT). Several biomarkers have been linked to metabolic derangements and may contribute to the pathogenicity of fat depots. We examined the association between fat depots on multidetector computed tomography and metabolic regulatory biomarkers. Participants from the Framingham Heart Study (n=1583, 47% women) underwent assessment of SAT, VAT, and liver attenuation. We measured circulating biomarkers secreted by adipose tissue or liver (adiponectin, leptin, leptin receptor, fatty acid binding protein 4, fetuin-A, and retinol binding protein 4). Using multivariable linear regression models, we examined relations of fat depots with biomarkers. Higher levels of fat depots were positively associated with leptin and fatty acid binding protein 4 but negatively associated with adiponectin (all P<0.001). Associations with leptin receptor, fetuin-A, and retinol binding protein 4 varied according to fat depot type or sex. When comparing the associations of SAT and VAT with biomarkers, VAT was the stronger correlate of adiponectin (β=-0.28 [women]; β=-0.30 [men]; both P<0.001), whereas SAT was the stronger correlate of leptin (β=0.62 [women]; β=0.49 [men]; both P<0.001; P<0.001 for comparing VAT versus SAT). Although fetuin-A and retinol binding protein 4 are secreted by the liver in addition to adipose tissue, associations of liver attenuation with these biomarkers was not stronger than that of SAT or VAT. SAT, VAT, and liver attenuation are associated with metabolic regulatory biomarkers with differences in the associations by fat depot type and sex. These findings support the possibility of biological differences between fat depots. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  2. Depot-specific Regulation of the Conversion of Cortisone to Cortisol in Human Adipose Tissue

    PubMed Central

    Lee, Mi-Jeong; Fried, Susan K.; Mundt, Steven S.; Wang, Yanxin; Sullivan, Sean; Stefanni, Alice; Daugherty, Bruce L.; Hermanowski-Vosatka, Anne

    2015-01-01

    Objective Our main objective was to compare the regulation of cortisol production within omental (Om) and abdominal subcutaneous (Abd sc) human adipose tissue. Methods and Procedures Om and Abd sc adipose tissue were obtained at surgery from subjects with a wide range of BMI. Hydroxysteroid dehydrogenase (HSD) activity (3H-cortisone and 3H-cortisol interconversion) and expression were measured before and after organ culture with insulin and/or dexamethasone. Results Type 1 HSD (HSD1) mRNA and reductase activity were mainly expressed within adipocytes and tightly correlated with adipocyte size within both depots. There was no depot difference in HSD1 expression or reductase activity, while cortisol inactivation and HSD2 mRNA expression (expressed in stromal cells) were higher in Om suggesting higher cortisol turnover in this depot. Culture with insulin decreased HSD reductase activity in both depots. Culture with dexamethasone plus insulin compared to insulin alone increased HSD reductase activity only in the Om depot. This depot-specific increase in reductase activity could not be explained by an alteration in HSD1 mRNA or protein, which was paradoxically decreased. However, in Om only, hexose-6-phosphate dehydrogenase (H6PDH) mRNA levels were increased by culture with dexamethasone plus insulin compared to insulin alone, suggesting that higher nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) production within the endoplasmic reticulum (ER) contributed to the higher HSD reductase activity. Discussion We conclude that in the presence of insulin, glucocorticoids cause a depot-specific increase in the activation of cortisone within Om adipose tissue, and that this mechanism may contribute to adipocyte hypertrophy and visceral obesity. PMID:18388900

  3. Depot naltrexone: long-lasting antagonism of the effects of heroin in humans

    PubMed Central

    Collins, Eric D.; Kleber, Herbert D.; Nuwayser, Elie S.; Kerrigan, James H.; Fischman, Marian W.

    2013-01-01

    Rationale Naltrexone, an opioid antagonist, is currently approved as a treatment for heroin dependence. However, naltrexone is generally not well accepted by patients, and medication non-compliance is a difficult obstacle to treatment. A sustained-release form of naltrexone may improve compliance. Objective The present study was designed to evaluate the time course, safety, and effectiveness of a depot formulation of naltrexone (Depotrex®). Methods Twelve heroin-dependent individuals participated in an 8-week inpatient study. After a 1-week detoxification period, six participants received 192 mg naltrexone base and six participants received 384 mg naltrexone base. For safety, the low dose of depot naltrexone was tested before the high dose. The effects of heroin (0, 6.25, 12.5, 18.75, 25 mg, IV) were evaluated for the next 6 weeks. One dose of heroin was tested per day on Mondays through Fridays, and the entire dose range was tested each week. Active heroin doses were administered in ascending order during the week, while placebo could be administered on any day. Subjective, performance, and physiological effects were measured both before and after heroin administration. The hypotheses were that depot naltrexone would antagonize the effects of heroin, and that the high dose of depot naltrexone would produce a more effective and longer-lasting antagonism than the low dose. Results The low and high doses of depot naltrexone antagonized heroin-induced subjective ratings for 3 and 5 weeks, respectively. Plasma levels of naltrexone remained above 1 ng/ml for approximately 3 and 4 weeks after administration of 192 mg and 384 mg naltrexone. Other than the initial discomfort associated with the injection of depot naltrexone, there were no untoward side-effects. Conclusions: These results suggest that this depot formulation of naltrexone provides a safe, effective, long-lasting antagonism of the effects of heroin. PMID:11823887

  4. Measurement of ground and nearby building vibration and noise induced by trains in a metro depot.

    PubMed

    Zou, Chao; Wang, Yimin; Wang, Peng; Guo, Jixing

    2015-12-01

    Metro depots are where subway trains are parked and where maintenance is carried out. They usually occupy the largest ground areas in metro projects. Due to land utilization problems, Chinese cities have begun to develop over-track buildings above metro depots for people's life and work. The frequently moving trains, when going into and out of metro depots, can cause excessive vibration and noise to over-track buildings and adversely affect the living quality of the building occupants. Considering the current need of reliable experimental data for the construction of metro depots, field measurements of vibration and noise on the ground and inside a nearby 3-story building subjected to moving subway trains were conducted in a metro depot at Guangzhou, China. The amplitudes and frequency contents of velocity levels were quantified and compared. The composite A-weighted equivalent sound levels and maximum sound levels were captured. The predicted models for vibration and noise of metro depot were proposed based on existing models and verified. It was found that the vertical vibrations were significantly greater than the horizontal vibrations on the ground and inside the building near the testing line. While at the throat area, the horizontal vibrations near the curved track were remarkably greater than the vertical vibrations. The attenuation of the vibrations with frequencies above 50 Hz was larger than the ones below 50 Hz, and the frequencies of vibration transmitting to adjacent buildings were mainly within 10-50 Hz. The largest equivalent sound level generated in the throat area was smaller than the testing line one, but the instantaneous maximum sound level induced by wheels squeal, contact between wheels and rail joints as well as turnout was close to or even greater than the testing line one. The predicted models gave a first estimation for design and assessment of newly built metro depots.

  5. Fueling systems

    SciTech Connect

    Gorker, G.E.

    1987-01-01

    This report deals with concepts of the Tiber II tokamak reactor fueling systems. Contained in this report are the fuel injection requirement data, startup fueling requirements, intermediate range fueling requirements, power range fueling requirements and research and development considerations. (LSR)

  6. Diffusion of dissolved CO2 in water propagating from a cylindrical bubble in a horizontal Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Peñas-López, Pablo; van Elburg, Benjamin; Parrales, Miguel A.; Rodríguez-Rodríguez, Javier

    2017-06-01

    The dissolution of a gas bubble in a confined geometry is a problem of interest in technological applications such as microfluidics or carbon sequestration, as well as in many natural flows of interest in geophysics. While the dissolution of spherical or sessile bubbles has received considerable attention in the literature, the case of a two-dimensional bubble in a Hele-Shaw cell, which constitutes perhaps the simplest possible confined configuration, has been comparatively less studied. Here, we use planar laser-induced fluorescence to experimentally investigate the diffusion-driven transport of dissolved CO2 that propagates from a cylindrical mm-sized bubble in air-saturated water confined in a horizontal Hele-Shaw cell. We observe that the radial trajectory of an isoconcentration front, rf(t ) , evolves in time as approximately rf-R0∝√{t } , where R0 denotes the initial bubble radius. We then characterize the unsteady CO2 concentration field via two simple analytical models, which are then validated against a numerical simulation. The first model treats the bubble as an instantaneous line source of CO2, whereas the second assumes a constant interfacial concentration. Finally, we provide an analogous Epstein-Plesset equation with the intent of predicting the dissolution rate of a cylindrical bubble.

  7. Scaling crossover in thin-film drag dynamics of fluid drops in the Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Okumura, Ko; Yahashi, Misato; Kimoto, Natsuki

    2016-11-01

    We study both experimentally and theoretically the descending motion due to gravity of a fluid drop surrounded by another immiscible fluid in a confined space between two parallel plates, i.e., in the Hele-Shaw cell. As a result, we show a new scaling regime of a nonlinear drag friction in viscous liquid that replaces the well-known Stokes' drag friction through a clear collapse of experimental data thanks to the scaling law. In the novel regime, the dissipation in the liquid thin film formed between the drop and cell walls governs the dynamics. The crossover of this scaling regime to another scaling regime in which the dissipation inside the droplet is dominant is clearly demonstrated and a phase diagram separating these scaling regimes is presented. To be published as, Y. Yahashi, N. Kimoto and K. Okumura, Scaling crossover in thin-film drag dynamics of fluid drops in the Hele-Shaw cell, Sci. Rep.(CC BY 4.0). This research was partly supported by ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan).

  8. Techno-economic analysis of a biomass depot

    SciTech Connect

    Jacobson, Jacob Jordan; Lamers, Patrick; Roni, Mohammad Sadekuzzaman; Cafferty, Kara Grace; Kenney, Kevin Louis; Heath, Brendi May; Hansen, Jason K

    2014-10-01

    The U.S. Department of Energy (DOE) Bioenergy Technologies Office (BETO) promotes the production of an array of liquid fuels and fuel blendstocks from lignocellulosic biomass feedstocks by funding fundamental and applied research that advances the state of technology in biomass collection, conversion, and sustainability. As part of its involvement in this program, the Idaho National Laboratory (INL) investigates the technical, economic, and environmental performance of different feedstock supply systems and their impacts on the downstream conversion processes.

  9. A Practical, Affordable Cryogenic Propellant Depot Based on ULA's Flight Experience

    NASA Technical Reports Server (NTRS)

    Kutter, Bernard F.; Zegler, Frank; O'Neil, Gary; Pitchford, Brian

    2008-01-01

    Mankind is embarking on the next step in the journey of human exploration. We are returning to the moon and eventually moving to Mars and beyond. The current Exploration architecture seeks a balance between the need for a robust infrastructure on the lunar surface, and the performance limitations of Ares I and V. The ability to refuel or top-off propellant tanks from orbital propellant depots offers NASA the opportunity to cost effectively and reliably satisfy these opposing requirements. The ability to cache large orbital quantities of propellant is also an enabling capability for missions to Mars and beyond. This paper describes an option for a propellant depot that enables orbital refueling supporting Exploration, national security, science and other space endeavors. This proposed concept is launched using a single EELV medium class rocket and thus does not require any orbital assembly. The propellant depot provides cryogenic propellant storage that utilizes flight proven technologies augmented with technologies currently under development. The propellant depot system, propellant management, flight experience, and key technologies are also discussed. Options for refueling the propellant depot along with an overview of Exploration architecture impacts are also presented.

  10. Neuroendocrine Tumors and Lanreotide Depot: Clinical Considerations and Nurse and Patient Preferences.

    PubMed

    Ryan, Pamela; Phan, Alexandria T; Adelman, Daphne T; Iwasaki, Michiko

    2016-12-01

    Somatostatin analogs (SSAs) are a mainstay therapy for the treatment of carcinoid syndrome associated with neuroendocrine tumors (NETs). They are effective for a range of gastroenteropancreatic NETs (GEP-NETs). Lanreotide depot (Somatuline®) is an SSA that is approved for the treatment of GEP-NETs to improve progression-free survival (PFS). The article reviews the efficacy, safety, and administration of lanreotide depot and relates those attributes to considerations and preferences of oncology nurses and their patients. A review of the literature on the use of lanreotide for the treatment of NETs and carcinoid syndrome was conducted. In addition, the literature on drug delivery and routes of administration was surveyed to provide context for comparative studies related to clinical and patient preferences. Lanreotide depot prolongs PFS and is well tolerated by patients who expressed satisfaction in the ability to control symptoms related to carcinoid syndrome. Nurses cited several benefits to using lanreotide depot in the clinical setting, including more time saved to address other patient care issues. Attributes of lanreotide depot-including its efficacy, safety and tolerability, dosing and administration, and cost-may contribute to healthcare decisions regarding the treatment and management of NETs.

  11. 33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... operations preclude safe entry. The restricted periods will be identified by the use of quick-flashing beacon... the entrance of Rich Passage. Entry into the area is prohibited when the quick-flashing beacons are in...

  12. 33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... operations preclude safe entry. The restricted periods will be identified by the use of quick-flashing beacon... the entrance of Rich Passage. Entry into the area is prohibited when the quick-flashing beacons are in...

  13. Depot medroxyprogesterone in the management of benign prostatic hyperplasia.

    PubMed

    Onu, P E

    1995-01-01

    The effects of depot medroxyprogesterone (DMPA), a 5 alpha-reductase, luteinizing-hormone release and human androgen receptor adhesion inhibitor, were assessed in 80 patients with benign prostatic hyperplasia (BPH) in a double-blind, placebo-controlled study. Patients were randomized to DMPA 150 mg single-dose intramuscular injection or placebo in a similar fashion. The following changes were seen with DMPA after 3 months (duration of DMPA effect): (1) serum testosterone reached castration levels within 3 days as compared to no changes in the placebo group; (2) the prostate volume was reduced by 25% compared to a 3% decrease with placebo (p < 0.001); (3) maximum urinary-flow rates increased by 3.7 ml/s compared to placebo (p < 0.001); (4) total urinary symptom scores decreased by 4.9 points compared to a nonsignificant decrease with placebo (p < 0.005). There was a 2.5-point decrease in irritative symptoms (urinary frequency, nocturia and urgency) as compared to a nonsignificant decrease with placebo (p < 0.005). After 3 months, the urinary symptoms and urodynamic changes were reversed but significantly greater than the baseline values (p < 0.001). The prostates showed regrowth to the initial sizes within 18-36 weeks. DMPA was better tolerated, except for a higher incidence of impotence, decreased libido and ejaculatory disorders, than in the placebo group. The quality of life is improved with DMPA since it did not produce hot flashes. It was concluded that single-dose DMPA 150 mg is a safe and effective treatment for prostatic obstruction where potency is a secondary consideration.

  14. Differential expression of Dlk-1 in bovine adipose tissue depots.

    PubMed

    Vuocolo, T; Pearson, R; Campbell, P; Tellam, R L

    2003-02-01

    Dlk-1, a type 1 membrane glycoprotein, is a member of the Epidermal Growth Factor-like family of homeotic proteins that are typically involved in cell fate decisions and in mice it has been implicated in the control of differentiation of adipocytes. The aim of this study was to determine whether there were tissue-specific expression patterns of Dlk-1 splice variants in bovine tissues. Only the Dlk-1-C2 variant was expressed in adult bovine tissues while both Dlk-1-C2 and Dlk-1-A variants were expressed in foetal tissues. Quantitative real-time PCR revealed large differences in the relative levels of expression of the Dlk-1-C2 variant in adult adipose tissue depots with no expression in subcutaneous and brisket adipose tissues. Expression was also demonstrated in three adult skeletal muscle samples. The large variation in the level of expression of Dlk-1-C2 in different adult tissues may reflect the relative preadipocyte content of those tissues and consequently their potential for generating new adipocytes. A low abundance soluble glycoprotein (bFA1) was purified from bovine amniotic fluid. Analyses of its amino acid sequence revealed that it corresponded to most of the extracellular domain of bovine Dlk-1 and was derived by proteolytic processing from the full-length Dlk-1 protein encoded by the Dlk-1-A variant. The tissues expressing the Dlk-1-A variant have not been identified but are likely to be foetal in origin. Splice variants of Dlk-1 may have varied functional roles with the foetal Dlk-1-A form capable of generating a protein that undergoes proteolytic processing to release a soluble ecto-domain of Dlk-1. In contrast the Dlk-1-C2 splice variant codes for a protein lacking this processing site and therefore it probably remains bound to the cell membrane.

  15. Bone density in women receiving depot medroxyprogesterone acetate for contraception.

    PubMed Central

    Cundy, T; Evans, M; Roberts, H; Wattie, D; Ames, R; Reid, I R

    1991-01-01

    OBJECTIVE--To determine if the use of the injectable contraceptive depot medroxyprogesterone (DMPA), which reduces ovarian oestrogen production, is associated with changes in bone density. DESIGN--Population study. DMPA users were compared with two control groups selected from larger population studies and individually matched for several putative determinants of bone density (age, race, body mass index, and years of oestrogen deficiency). Controls and DMPA users were matched without prior knowledge of their bone density measurements. SETTING--Teaching hospital and community family planning clinics. SUBJECTS--30 current users of DMPA with a minimum five years' previous use, 30 premenopausal controls, and 30 postmenopausal controls. MAIN OUTCOME MEASURE--Lumbar spine and femoral neck bone mineral density assessed by dual energy x ray absorptiometry. RESULTS--Compared with premenopausal controls matched for age, race, and body mass index, DMPA users had significantly reduced bone density in the lumbar spine (mean difference 7.5% (95% confidence interval 1.9% to 13.1%), p = 0.002) and in the femoral neck (6.6%, (0.8% to 12.3%), p = 0.007). Compared with postmenopausal controls matched for body mass index and duration of oestrogen deficiency, DMPA users had greater bone density in the lumbar spine (8.9% (4.3% to 13.5%), p = 0.001), but in the femoral neck the difference in bone density was less (4.0% (-0.4% to 8.5%), p = 0.04). CONCLUSIONS--Women using DMPA have bone density values intermediate between those of normal premenopausal and postmenopausal controls; thus, the degree of oestrogen deficiency induced by DMPA may have an adverse effect on bone density. PMID:1830502

  16. Bringing Froebel into London's Infant Schools: The Reforming Practice of Two Head Teachers, Elizabeth Shaw and Frances Roe, from the 1890s to the 1930s

    ERIC Educational Resources Information Center

    Read, Jane

    2013-01-01

    This article explores how infant school reform took hold in London's schools from the 1890s to the 1930s through examination of the work of two Froebelian head teachers, Elizabeth Mary Shaw and Frances Emily Roe. In contrast to teacher-led rote-learning methods and rigid discipline they implemented play-based activities drawing on children's…

  17. Save Energy Now (SEN) Assessment Helps Expand Energy Management Program at Shaw Industries: Flooring Company Saves $872,000 Annually by Improving Steam System Efficiency

    SciTech Connect

    Not Available

    2008-07-01

    This case study describes how the Shaw Industries plant #20 in Dalton, Georgia, achieved annual savings of $872,000 and 93,000 MMBtu after receiving a DOE Save Energy Now energy assessment and implementing recommendations to improve the efficiency of its steam system.

  18. Bringing Froebel into London's Infant Schools: The Reforming Practice of Two Head Teachers, Elizabeth Shaw and Frances Roe, from the 1890s to the 1930s

    ERIC Educational Resources Information Center

    Read, Jane

    2013-01-01

    This article explores how infant school reform took hold in London's schools from the 1890s to the 1930s through examination of the work of two Froebelian head teachers, Elizabeth Mary Shaw and Frances Emily Roe. In contrast to teacher-led rote-learning methods and rigid discipline they implemented play-based activities drawing on children's…

  19. Artificial intelligence technology assessment for the US Army Depot System Command

    SciTech Connect

    Pennock, K A

    1991-07-01

    This assessment of artificial intelligence (AI) has been prepared for the US Army's Depot System Command (DESCOM) by Pacific Northwest Laboratory. The report describes several of the more promising AI technologies, focusing primarily on knowledge-based systems because they have been more successful in commercial applications than any other AI technique. The report also identifies potential Depot applications in the areas of procedural support, scheduling and planning, automated inspection, training, diagnostics, and robotic systems. One of the principal objectives of the report is to help decisionmakers within DESCOM to evaluate AI as a possible tool for solving individual depot problems. The report identifies a number of factors that should be considered in such evaluations. 22 refs.

  20. Energy engineering analysis program, Anniston Army Depot; Energy Survey of Industrial Facilities (Ind); executive summary

    SciTech Connect

    1988-11-01

    This report presents the results of the Army Industrial Facility Energy Survey of the Army Tank Rebuild Area at Anniston Army Depot (AAD). This project is being performed by Science Applications International Corporation (SAIC) under Contract No. DACA01-83-C-00099. The report includes an analyses of energy use within the industrial area, and supplies the identification and evaluation of energy conservation opportunities. The results obtained from the recommended projects indicate that the energy use of the manufacturing area could be reduced by 25 percent. Such savings assume that there will be no change in the level of production as well as no change in the production hours. Anniston Army Depot is commonly known as the Tank rebuild center of the free world and ranks among the largest US ammunition storage facilities. It is a part of the Army`s Depot System Command (DESCOM), which is a major subordinate command bf the US Army Materiel Development and Readiness Command (DARCOM).

  1. A cellular model for the investigation of depot specific human adipocyte biology

    PubMed Central

    Todorčević, Marijana; Hilton, Catriona; McNeil, Catriona; Christodoulides, Constantinos; Hodson, Leanne; Karpe, Fredrik

    2017-01-01

    ABSTRACT Upper-body adiposity is associated with increased metabolic disease risk, while lower-body adiposity is paradoxically protective. Efforts to understand the underlying mechanisms require appropriate and reproducible in vitro culture models. We have therefore generated immortalised (im) human preadipocyte (PAD) cell lines derived from paired subcutaneous abdominal and gluteal adipose tissue. These cell lines, denoted imAPAD and imGPAD display enhanced proliferation and robust adipogenic capacities. Differentiated imAPAD and imGPAD adipocytes synthesize triglycerides de novo and respond lipolytically to catecholamine-stimulation. Importantly the cells retain their depot-of-origin ‘memory’ as reflected by inherent differences in fatty acid metabolism and expression of depot-specific developmental genes. These features make these cell lines an invaluable tool for the in vitro investigation of depot-specific human adipocyte biology.

  2. Multi-depot Vehicle Routing Problem with Pickup and Delivery Requests

    NASA Astrophysics Data System (ADS)

    Sombuntham, Pandhapon; Kachitvichyanukul, Voratas

    2010-10-01

    This paper considers a multi-depot vehicle routing problem with pickup and delivery requests. In the problem of interest, each location may have goods for both pickup and delivery with multiple delivery locations that may not be the depots. These characteristics are quite common in industrial practice. A particle swarm optimization algorithm with multiple social learning structures is proposed for solving the practical case of multi-depot vehicle routing problem with simultaneous pickup and delivery and time window. A new decoding procedure is implemented using the PSO class provided in the ETLib object library. Computational experiments are carried out using the test instances for the pickup and delivery problem with time windows (PDPTW) as well as a newly generated instance. The preliminary results show that the proposed algorithm is able to provide good solutions to most of the test problems.

  3. 33 CFR 334.270 - York River adjacent to Cheatham Annex Depot, Naval Supply Center, Williamsburg, Va.; restricted...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Annex Depot, Naval Supply Center, Williamsburg, Va.; restricted area. 334.270 Section 334.270 Navigation..., Williamsburg, Va.; restricted area. (a) The area. The waters of York River bounded as follows: Beginning at a... Officer in Charge, Cheatham Annex Depot, Naval Supply Center, Williamsburg, Virginia. (2) The...

  4. 33 CFR 334.270 - York River adjacent to Cheatham Annex Depot, Naval Supply Center, Williamsburg, Va.; restricted...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Annex Depot, Naval Supply Center, Williamsburg, Va.; restricted area. 334.270 Section 334.270 Navigation..., Williamsburg, Va.; restricted area. (a) The area. The waters of York River bounded as follows: Beginning at a... Officer in Charge, Cheatham Annex Depot, Naval Supply Center, Williamsburg, Virginia. (2) The...

  5. Energy Engineering Analysis Program, limited energy study of steam distribution systems, Hawthorne Army Ammunition Depot, Hawthorne, Nevada. Programming documents

    SciTech Connect

    1995-09-01

    The project is a significant part of Hawthorne Army Ammunition Depot`s effort to achieve a 20-percent reduction in energy consumption by FY2000 versus FY1985 baseline levels. The project will also assure that heating services are provided to Industrial Area facilities on a continuing basis, supporting mission requirements.

  6. Examining a Paradigm Shift in Organic Depot-Level Software Maintenance for Army Communications and Electronics Equipment

    DTIC Science & Technology

    2015-05-30

    Examining a Paradigm Shift in Organic Depot- Level Software Maintenance for Army Communications and Electronics Equipment Randolph L...Depot- Level Maintenance ..................................................... 83 v List of Figures Figure 1 – Software Trends Over Time...hardware reliability, a focus on consumable product lines, and ever-intensive software systems. With defense acquisition having little influence on

  7. Spatiotemporally Photoradiation-Controlled Intratumoral Depot for Combination of Brachytherapy and Photodynamic Therapy for Solid Tumor

    PubMed Central

    Mukerji, Ratul; Schaal, Jeffrey; Li, Xinghai; Bhattacharyya, Jayanta; Asai, Daisuke; Zalutsky, Michael R.; Chilkoti, Ashutosh; Liu, Wenge

    2015-01-01

    In an attempt to spatiotemporally control both tumor retention and the coverage of anticancer agents, we developed a photoradiation-controlled intratumoral depot (PRCITD) driven by convention enhanced delivery (CED). This intratumoral depot consists of recombinant elastin-like polypeptide (ELP) containing periodic cysteine residues and is conjugated with a photosensitizer, chlorin-e6 (Ce6) at the N-terminus of the ELP. We hypothesized that this cysteine-containing ELP (cELP) can be readily crosslinked through disulfide bonds upon exposure to oxidative agents, specifically the singlet oxygen produced during photodynamic stimulation. Upon intratumoral injection, CED drives the distribution of the soluble polypeptide freely throughout the tumor interstitium. Formation and retention of the depot was monitored using fluorescence molecular tomography imaging. When imaging shows that the polypeptide has distributed throughout the entire tumor, 660-nm light is applied externally at the tumor site. This photo-radiation wavelength excites Ce6 and generates reactive oxygen species (ROS) in the presence of oxygen. The ROS induce in situ disulfide crosslinking of the cysteine thiols, stabilizing the ELP biopolymer into a stable therapeutic depot. Our results demonstrate that this ELP design effectively forms a hydrogel both in vitro and in vivo. These depots exhibit high stability in subcutaneous tumor xenografts in nude mice and significantly improved intratumoral retention compared to controls without crosslinking, as seen by fluorescent imaging and iodine-125 radiotracer studies. The photodynamic therapy provided by the PRCITD was found to cause significant tumor inhibition in a Ce6 dose dependent manner. Additionally, the combination of PDT and intratumoral radionuclide therapy co-delivered by PRCITD provided a greater antitumor effect than either monotherapy alone. These results suggest that the PRCITD could provide a stable platform for delivering synergistic, anti

  8. Are depot as effective as oral antipsychotics on first-episode psychosis?

    PubMed

    Orus, Cristián; Aceituno, David

    2016-05-23

    Depot antipsychotics have been generally used in patients with chronic schizophrenia with adherence problems to oral therapy. However, it has been suggested they can be a good alternative in earlier stages too. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified three systematic reviews including two pertinent randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded it is not clear whether there are differences between depot and oral antipsychotics in first-episode psychosis because the certainty of the available evidence is very low.

  9. Enhanced Preliminary Assessment Report: Fort Wingate Depot Activity Gallup, New Mexico

    DTIC Science & Technology

    1990-03-01

    Fort Wingate Depot Activity * Gallup, New Mexico I fMarch 1990 DTIC I il E-LEcTrEII JUN 12 1990U Is eQ prepared for U Commander U.S. Army Toxic and...Activity Gallup, New Mexico March 1990 prepared for Commander, U.S. Army Toxic and Hazardous Materials Agency, Aberdeen Proving Ground, Maryland 21010...Claslification) Enhanced Preliminary Assessment Report: Fort Wingate Depot Activity, Gallup, New Mexico 12. PERSONAL AUTHOR(S) 3a. TYPE OF REPORT 13b

  10. Percolation in a Proton Exchange Membrane Fuel Cell Catalyst Layer

    SciTech Connect

    Stacy, Stephen; Allen, Jeffrey

    2012-07-01

    Water management in the catalyst layers of proton exchange membrane fuel cells (PEMFC) is confronted by two issues, flooding and dry out, both of which result in improper functioning of the fuel cell and lead to poor performance and degradation. At the present time, the data that has been reported about water percolation and wettability within a fuel cell catalyst layer is limited. A method and apparatus for measuring the percolation pressure in the catalyst layer has been developed based upon an experimental apparatus used to test water percolation in porous transport layers (PTL). The experimental setup uses a pseudo Hele-Shaw type testing where samples are compressed and a fluid is injected into the sample. Testing the samples gives percolation pressure plots which show trends in increasing percolation pressure with an increase in flow rate. A decrease in pressure was seen as percolation occurred in one sample, however the pressure only had a rising effect in the other sample.

  11. Scaling crossover in thin-film drag dynamics of fluid drops in the Hele-Shaw cell

    PubMed Central

    Yahashi, Misato; Kimoto, Natsuki; Okumura, Ko

    2016-01-01

    We study both experimentally and theoretically the descending motion due to gravity of a fluid drop surrounded by another immiscible fluid in a confined space between two parallel plates, i.e., in the Hele-Shaw cell. As a result, we show a new scaling regime of a nonlinear drag friction in viscous liquid that replaces the well-known Stokes’ drag friction through a clear collapse of experimental data thanks to the scaling law. In the novel regime, the dissipation in the liquid thin film formed between the drop and cell walls governs the dynamics. The crossover of this scaling regime to another scaling regime in which the dissipation inside the droplet is dominant is clearly demonstrated and a phase diagram separating these scaling regimes is presented. PMID:27562151

  12. Scaling crossover in thin-film drag dynamics of fluid drops in the Hele-Shaw cell.

    PubMed

    Yahashi, Misato; Kimoto, Natsuki; Okumura, Ko

    2016-08-26

    We study both experimentally and theoretically the descending motion due to gravity of a fluid drop surrounded by another immiscible fluid in a confined space between two parallel plates, i.e., in the Hele-Shaw cell. As a result, we show a new scaling regime of a nonlinear drag friction in viscous liquid that replaces the well-known Stokes' drag friction through a clear collapse of experimental data thanks to the scaling law. In the novel regime, the dissipation in the liquid thin film formed between the drop and cell walls governs the dynamics. The crossover of this scaling regime to another scaling regime in which the dissipation inside the droplet is dominant is clearly demonstrated and a phase diagram separating these scaling regimes is presented.

  13. Of mice and men: evolution and the socialist utopia. William Morris, H.G. Wells, and George Bernard Shaw.

    PubMed

    Hale, Piers J

    2010-01-01

    During the British socialist revival of the 1880s competing theories of evolution were central to disagreements about strategy for social change. In News from Nowhere (1891), William Morris had portrayed socialism as the result of Lamarckian processes, and imagined a non-Malthusian future. H.G. Wells, an enthusiastic admirer of Morris in the early days of the movement, became disillusioned as a result of the Malthusianism he learnt from Huxley and his subsequent rejection of Lamarckism in light of Weismann's experiments on mice. This brought him into conflict with his fellow Fabian, George Bernard Shaw, who rejected neo-Darwinism in favour of a Lamarckian conception of change he called "creative evolution."

  14. Morphological stability of an interface between two non-Newtonian fluids moving in a Hele-Shaw cell.

    PubMed

    Martyushev, L M; Birzina, A I

    2015-01-01

    The problem of the morphological stability of an interface in the case of the displacement of one non-Newtonian fluid by another non-Newtonian fluid in a radial Hele-Shaw cell has been considered. Both fluids have been described by the two-parameter Ostwald-de Waele power-law model. The nonzero viscosity of the displacing fluid has been taken into account. A generalized Darcy's law for the system under consideration, as well as an equation for the determination of the critical size of morphological stability with respect to harmonic perturbations (linear analysis), has been derived. Morphological phase diagrams have been constructed, and the region of the parameters in which nonequilibrium reentrant morphological transitions are possible has been revealed.

  15. Droplet migration in a Hele-Shaw cell: Effect of the lubrication film on the droplet dynamics

    NASA Astrophysics Data System (ADS)

    Ling, Yue; Fullana, Jose-Maria; Popinet, Stéphane; Josserand, Christophe

    2016-06-01

    Droplet migration in a Hele-Shaw cell is a fundamental multiphase flow problem which is crucial for many microfluidics applications. We focus on the regime at low capillary number and three-dimensional direct numerical simulations are performed to investigate the problem. In order to reduce the computational cost, an adaptive mesh is employed and high mesh resolution is only used near the interface. Parametric studies are performed on the droplet horizontal radius and the capillary number. For droplets with an horizontal radius larger than half the channel height, the droplet overfills the channel and exhibits a pancake shape. A lubrication film is formed between the droplet and the wall and particular attention is paid to the effect of the lubrication film on the droplet velocity. The computed velocity of the pancake droplet is shown to be lower than the average inflow velocity, which is in agreement with experimental measurements. The numerical results show that both the strong shear induced by the lubrication film and the three-dimensional flow structure contribute to the low mobility of the droplet. In this low-migration-velocity scenario, the interfacial flow in the droplet reference frame moves toward the rear on the top and reverses direction moving to the front from the two side edges. The velocity of the pancake droplet and the thickness of the lubrication film are observed to decrease with capillary number. The droplet velocity and its dependence on capillary number cannot be captured by the classic Hele-Shaw equations, since the depth-averaged approximation neglects the effect of the lubrication film.

  16. Fossil fuels -- future fuels

    SciTech Connect

    1998-03-01

    Fossil fuels -- coal, oil, and natural gas -- built America`s historic economic strength. Today, coal supplies more than 55% of the electricity, oil more than 97% of the transportation needs, and natural gas 24% of the primary energy used in the US. Even taking into account increased use of renewable fuels and vastly improved powerplant efficiencies, 90% of national energy needs will still be met by fossil fuels in 2020. If advanced technologies that boost efficiency and environmental performance can be successfully developed and deployed, the US can continue to depend upon its rich resources of fossil fuels.

  17. Uniform fatty acid mobilization from anatomically distinct fat depots in the sable (Martes zibellina).

    PubMed

    Nieminen, Petteri; Mustonen, Anne-Mari

    2007-07-01

    The mobilization of fatty acids (FA) is a selective process in humans, rodents and the few previously studied carnivores. The FA composition of and mobilization from different fat depots reflect the functions of adipose tissues, e.g. in energy storage or insulation. Sixteen farm-raised sables (Martes zibellina), a terrestrial mustelid, were assigned into a fed control group or fasted for 4 days. The FA composition of the sable was relatively similar to other previously studied mustelids. The masses of the different fat depots decreased by 28-55% during fasting. The subcutaneous (sc) and intraabdominal (iab) fats had a uniform FA composition and the sable could mobilize both sc and iab FA. 18:3n-3, 18:4n-3 and 16:1n-7 were effectively mobilized, while long-chain saturated (SFA) and monounsaturated FA (MUFA) increased in proportion. Relative mobilization (RM) correlated inversely with the FA chain length and Delta9-desaturation increased RM of several MUFA compared to SFA. The results reinforce the hypothesis that the terrestrial sable can utilize sc and iab fat depots as energy reserves during nutritional scarcity. The natural history of the species is an important determinant of the FA composition and RM between anatomically different fat depots.

  18. Stromal vascular cells and adipogenesis: Cells within adipose depots regulate adipogenesis

    USDA-ARS?s Scientific Manuscript database

    A collection of investigations indicate the importance of adipose tissue stromal/stem cells to vasculogenesis and angiogenesis during adipogenesis. Early in development the stromal-vascular (S-V) elements control and dictate the extent of adipogenesis in a depot dependent manner. For instance, the...

  19. Tests of the higher order turbulence model for atmospheric circulations (HOTMAC) at Deseret Chemical Depot

    SciTech Connect

    Costigan, K.R.

    1998-11-01

    Deseret Chemical Depot is one of the US Army`s storage facilities for its stockpile of chemical weapon agents. Congress has directed the Department of Defense to eliminate the aging stockpiles, which have existed since the end of World War II, and the US Army is destroying these lethal chemical munitions. Although the danger is slight, accurate predictions of the wind field in the valley are necessary for dispersion calculations in the event of an accident involving toxic chemicals at the depot. There are several small communities in Rush and Tooele valleys, including the town of Tooele, and Salt Lake City is located 65 km to the Northeast of Deseret Chemical Depot South area, at 1,300 m MSL and beyond the Oquirrh Mountains. The purpose of this report is to carry out three-dimensional numerical simulations of the atmospheric circulations in the region around Deseret Chemical Depot with the Higher Order Turbulence Model for Atmospheric Circulations (HOTMAC) and to evaluate the performance of the model. The code had been modified to assimilate local meteorological observations through the use of Newtonian nudging. The nudging scheme takes advantage of the extensive network of local observations in the valley.

  20. Electrospark Deposition for Depot- and Field-Level Component Repair and Replacement of Hard Chromium Plating

    DTIC Science & Technology

    2008-02-01

    2008 to 00-00-2008 4. TITLE AND SUBTITLE Electrospark Deposition for Depot- and Field-Level Component Repair and Replacement of Hard Chromium... electrospark deposition ESOH environmental, safety and occupational health ESTCP Environmental Security Technology Certification Program GEAE GE...returning components to service more rapidly. Electrospark deposition (ESD), also known as electrospark alloying (ESA), is a microwelding technique that

  1. Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty.

    PubMed

    Freire, Analía Verónica; Gryngarten, Mirta Graciela; Ballerini, María Gabriela; Arcari, Andrea Josefina; Escobar, María Eugenia; Bergadá, Ignacio; Ropelato, María Gabriela

    2016-01-01

    Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E2-24h) after injection of depot triptorelin 3.75 mg were measured, at first dose and at 3, 6, 12, 18 and 24 months of treatment. E2-24h after depot triptorelin was >100 pg/ml after the first dose. Estradiol response (E2-24h) fell to levels <14 pg/ml in 78 out of 82 follow-up visits along 2 years of therapy. Concomitantly, LH-3h and FSH-3h were <4.0 and <6.3 IU/l, respectively. In 4 patients with inadequate treatment, E2-24h, LH-3h and FSH-3h rose to pubertal values similar to those observed at first dose. Estradiol (<14 pg/ml) assessment 24 h after depot triptorelin administration is a reliable and simple manner to confirm ovarian suppression in CPP girls during treatment. © 2015 S. Karger AG, Basel.

  2. Depot Sales of Goods and Services to Private Parties: Pricing in Partnering Agreements

    DTIC Science & Technology

    2003-07-01

    Public - private partnerships are agreements among organic depot maintenance activities and private industries or other entities to perform work or...shared risk than less collaborative business arrangements. Because the effort to build strong public - private partnerships within the Department of Defense

  3. Analysis of the Costs and Benefits of the USMC Light Armored Vehicle Depot Maintenance (IROAN) Program

    DTIC Science & Technology

    2006-12-01

    15 . NUMBER OF PAGES 55 14. SUBJECT TERMS Cost-Benefit, Depot Maintenance, Light Armored Vehicles 16. PRICE CODE 17. SECURITY... 15 A. APPROACH................................................................................................... 15 B. DATA SOURCES...21 Figure 14. Operating Forces LAV 25 avg readiness against time since last overhaul......24 Figure 15

  4. Current trend in drug delivery considerations for subcutaneous insulin depots to treat diabetes.

    PubMed

    P V, Jayakrishnapillai; Nair, Shantikumar V; Kamalasanan, Kaladhar

    2017-05-01

    Diabetes mellitus (DM) is a metabolic disorder due to irregularities in glucose metabolism, as a result of insulin disregulation. Chronic DM (Type 1) is treated by daily insulin injections by subcutaneous route. Daily injections cause serious patient non-compliance and medication non-adherence. Insulin Depots (ID) are parenteral formulations designed to release the insulin over a specified period of time, to control the plasma blood glucose level for intended duration. Physiologically, pancreas produces and secretes insulin in basal and pulsatile mode into the blood. Delivery systems mimicking basal release profiles are known as open-loop systems and current marketed products are open-loop systems. Future trend in open-loop systems is to reduce the number of injections per week by enhancing duration of action, by modifying the depot properties. The next generation technologies are closed-loop systems that mimic the pulsatile mode of delivery by pancreas. In closed-loop systems insulin will be released in response to plasma glucose. This review focuses on future trend in open-loop systems; by understanding (a) the secretion of insulin from pancreas, (b) the insulin regulation normal and in DM, (c) insulin depots and (d) the recent progress in open-loop depot technology particularly with respect to nanosystems. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Evaluation of cryogenic system test options for the OTV on-orbit propellant depot

    NASA Technical Reports Server (NTRS)

    Schuster, John R.; Alton, T. James; Brown, Norman S.; Hueter, Uwe

    1987-01-01

    Future space missions to geosynchronous, lunar, and planetary orbits will require an orbital depot for stockpiling propellants. This depot will provide long-term storage of cryogens, requiring new technologies for fluid management in microgravity and further development of thermal management technologies for minimization of cryogen boiloff. Preliminary evaluations have been made to define a test program approach for reducing technical risk through verifying performance models and building a base of engineering data for depot design. A number of testing options were defined and evaluated, leading to selection of ground testing combined with an orbital systems test. Ground testing is inadequate because of critical microgravity concerns; extending testing aboard the Space Station was eliminated because the data would not be available soon enough to benefit the propellant depot design. The orbital test would either be a short-term test carried out in the cargo bay of the Space Shuttle Orbiter using a nonhazardous cryogen or a longer term test carried out with hydrogen aboard a free-flying experiment orbited with an expendable launch vehicle.

  6. 33 CFR 334.850 - Lake Erie, west end, north of Erie Ordnance Depot, Lacarne, Ohio.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....850 Lake Erie, west end, north of Erie Ordnance Depot, Lacarne, Ohio. (a) The danger zone: Consists of the waters of Lake Erie within: (1) Danger Area I. The sector of a circle with a radius of 6,500 yards... and automatic weapons impact area. (c) Authorized dates and hours of firing: (1) Danger Area I. 6...

  7. Safety Extension Study Of Leuprolide Acetate (Lupron Depot) In The Treatment Of Central Precocious Puberty

    ClinicalTrials.gov

    2014-01-08

    Precocious; Leuprolide Acetate; Luteinizing Hormone (LH); Gonadotrophin-releasing Hormone Agonist (GnRHa); Tanner Staging; Depot Formulation; Suppression of LH; Central Precocious Puberty (CPP); Gonadotrophin-releasing Hormone (GnRH); Lupron; GnRH Analog; Pediatrics Central Precocious Puberty

  8. Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice.

    PubMed

    Wueest, Stephan; Yang, Xingyuan; Liu, Jun; Schoenle, Eugen J; Konrad, Daniel

    2012-01-01

    Given the strong link between visceral adiposity and (hepatic) insulin resistance as well as liver steatosis, it is crucial to characterize obesity-associated alterations in adipocyte function, particularly in fat depots drained to the liver. Yet these adipose tissues are not easily accessible in humans, and the most frequently studied depot in rodents is the perigonadal, which is drained systemically. In the present study, we aimed to study alterations in lipolysis between mesenteric and perigonadal adipocytes in mice. Basal free fatty acid and glycerol release was significantly lower in perigonadal compared with mesenteric adipocytes isolated from chow-fed C57BL/6J mice. However, this difference completely vanished in high-fat diet-fed mice. Consistently, protein levels of the G(0)/G(1) switch gene 2 (G0S2), which were previously found to be inversely related to basal lipolysis, were significantly lower in mesenteric compared with perigonadal fat of chow-fed mice. Similarly, perilipin was differently expressed between the two depots. In addition, adipocyte-specific overexpression of G0S2 led to significantly decreased basal lipolysis in mesenteric adipose tissue of chow-fed mice. In conclusion, lipolysis is differently regulated between perigonadal and mesenteric adipocytes, and these depot-specific differences might be explained by altered regulation of G0S2 and/or perilipin.

  9. The Feasibility of Solar Energy Usage on Red River Army Depot.

    DTIC Science & Technology

    This feasibility study considers the usage of solar energy to heat and cool the main office buildings on the Red River Army Depot, Texarkana Texas... Solar Energy costs are compared with the present heating and cooling system costs with an economic analysis using the annual worth and present worth methods.

  10. Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning.

    PubMed

    Yang, Guang-Zhi; Li, Jiao-Jiao; Yu, Deng-Guang; He, Mei-Feng; Yang, Jun-He; Williams, Gareth R

    2017-01-27

    Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62±0.07μm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.

  11. Evaluation of cryogenic system test options for the OTV on-orbit propellant depot

    NASA Technical Reports Server (NTRS)

    Schuster, John R.; Alton, T. James; Brown, Norman S.; Hueter, Uwe

    1987-01-01

    Future space missions to geosynchronous, lunar, and planetary orbits will require an orbital depot for stockpiling propellants. This depot will provide long-term storage of cryogens, requiring new technologies for fluid management in microgravity and further development of thermal management technologies for minimization of cryogen boiloff. Preliminary evaluations have been made to define a test program approach for reducing technical risk through verifying performance models and building a base of engineering data for depot design. A number of testing options were defined and evaluated, leading to selection of ground testing combined with an orbital systems test. Ground testing is inadequate because of critical microgravity concerns; extending testing aboard the Space Station was eliminated because the data would not be available soon enough to benefit the propellant depot design. The orbital test would either be a short-term test carried out in the cargo bay of the Space Shuttle Orbiter using a nonhazardous cryogen or a longer term test carried out with hydrogen aboard a free-flying experiment orbited with an expendable launch vehicle.

  12. 78 FR 77108 - Surplus Property Notice at a Military Installation Designated for Disposal: Pueblo Chemical Depot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF DEFENSE Department of the Army Surplus Property Notice at a Military Installation Designated for Disposal: Pueblo Chemical Depot, Colorado AGENCY: Department of the Army, DoD. ACTION: Notice. SUMMARY: This notice provides...

  13. (*) Central Growth Factor Loaded Depots in Bone Tissue Engineering Scaffolds for Enhanced Cell Attraction.

    PubMed

    Quade, Mandy; Knaack, Sven; Akkineni, Ashwini Rahul; Gabrielyan, Anastasia; Lode, Anja; Rösen-Wolff, Angela; Gelinsky, Michael

    2017-08-01

    Tissue engineering, the application of stem and progenitor cells in combination with an engineered extracellular matrix, is a promising strategy for bone regeneration. However, its success is limited by the lack of vascularization after implantation. The concept of in situ tissue engineering envisages the recruitment of cells necessary for tissue regeneration from the host environment foregoing ex vivo cell seeding of the scaffold. In this study, we developed a novel scaffold system for enhanced cell attraction, which is based on biomimetic mineralized collagen scaffolds equipped with a central biopolymer depot loaded with chemotactic agents. In humid milieu, as after implantation, the signaling factors are expected to slowly diffuse out of the central depot forming a gradient that stimulates directed cell migration toward the scaffold center. Heparin, hyaluronic acid, and alginate have been shown to be capable of depot formation. By using vascular endothelial growth factor (VEGF) as model factor, it was demonstrated that the release kinetics can be adjusted by varying the depot composition. While alginate and hyaluronic acid are able to reduce the initial burst and prolong the release of VEGF, the addition of heparin led to a much stronger retention that resulted in an almost linear release over 28 days. The biological activity of released VEGF was proven for all variants using an endothelial cell proliferation assay. Furthermore, migration experiments with endothelial cells revealed a relationship between the degree of VEGF retention and migration distance: cells invaded deepest in scaffolds containing a heparin-based depot indicating that the formation of a steep gradient is crucial for cell attraction. In conclusion, this novel in situ tissue engineering approach, specifically designed to recruit and accommodate endogenous cells upon implantation, appeared highly promising to stimulate cell invasion, which in turn would promote vascularization and finally new

  14. Assessment of goat fat depots using ultrasound technology and multiple multivariate prediction models.

    PubMed

    Peres, A M; Dias, L G; Joy, M; Teixeira, A

    2010-02-01

    Assessment of fat depots for several goat body parts is an expensive and time-consuming task requiring a trained technician. Therefore, the establishment of models to predict fat depots based on data requiring simpler and easier procedures, such as ultrasound measurements, that could be carried out in vivo, would be a major advantage. An interesting alternative to the use of multiple linear regression models is the use of partial least squares or artificial neural network models because they allow the establishment of one model to simultaneously predict different fat depots of interest. In this work, the applicability of these models to simultaneously predict 7 goat fat depots (subcutaneous fat, intermuscular fat, total carcass fat, omental fat, kidney and pelvic fat, mesenteric fat, and total body fat) was investigated. Although satisfactory correlation and prediction results were obtained using the multiple partial least squares model (cross-verification and validation R(2) and standard prediction error values between 0.66 and 0.98 and 247 and 2,168, respectively), the best global correlation and prediction performances were achieved with the multiple radial basis function artificial neural network (verification and validation R(2) and standard prediction error values between 0.82 and 0.96 and 304 and 1,707, respectively). These 2 multiple models allowed correlating and predicting simultaneously the 7 goat fat depots based on the goat BW and on only 2 ultrasonic measures (lumbar subcutaneous fat between fifth and sixth vertebrae and the fat depth at the third sternebra). Moreover, both multiple models showed better results compared with those obtained with multiple linear regression models proposed in previous work.

  15. The washout rate of a subcutaneous 99mTc-HSA depot in lower extremity lymphoedema.

    PubMed

    Jensen, Mads R; Simonsen, Lene; Karlsmark, Tonny; Bülow, Jens

    2012-03-01

    Lymphoscintigraphy is currently the leading diagnostic modality of lower extremity lymphoedema but has been criticized for being unreliable. Washout rate constants have been investigated and proven to be of diagnostic value in several studies of breast-cancer-related lymphoedema; however, the applicability in lower extremity lymphoedema needs further evaluation. The aim of the study was to verify if washout of (99m) Tc-human serum albumin ((99m) Tc-HSA) is a reliable diagnostic tool in lower extremity lymphoedema. Twenty healthy volunteers and eight patients (11 legs) with lymphoscintigraphy verified lower extremity lymphoedema participated in the study. A depot consisting of 0.1 ml 10 MBq/ml (99m) Tc-HSA was injected subcutaneously into the dorsum of each foot. The depot washout rate was measured using a portable scintillation detector system and time-activity curves were generated. After 30 min of supine rest and 10 min of standardized ergometric exercise, measurements were recorded for 20 min. Following correction for physical decay of (99m) Tc, the depot washout rate constant was calculated using linear regression analysis. Finally depot half-life was calculated from the washout rate constant. Median half-life for healthy volunteers was 9.4 h (range 2.5-28.3 h). Median half-life for lymphoedema patients was 10.7 h (range 1.5-35.1 h). No statistical significant difference could be detected between healthy volunteers and lymphoedema patients (P = 0.78). The washout rate of a subcutaneous (99m) Tc-HSA depot is not a reliable diagnostic tool in examination of lower extremity lymphoedema. Additional examinations revealed in vivo instability of the utilized (99m) Tc-HSA as the likely reason. © 2011 The Authors. Clinical Physiology and Functional Imaging © 2011 Scandinavian Society of Clinical Physiology and Nuclear Medicine.

  16. Heat shock proteins: in vivo heat treatments reveal adipose tissue depot-specific effects.

    PubMed

    Rogers, Robert S; Beaudoin, Marie-Soleil; Wheatley, Joshua L; Wright, David C; Geiger, Paige C

    2015-01-01

    Heat treatments (HT) and the induction of heat shock proteins (HSPs) improve whole body and skeletal muscle insulin sensitivity while decreasing white adipose tissue (WAT) mass. However, HSPs in WAT have been understudied. The purpose of the present study was to examine patterns of HSP expression in WAT depots, and to examine the effects of a single in vivo HT on WAT metabolism. Male Wistar rats received HT (41°C, 20 min) or sham treatment (37°C), and 24 h later subcutaneous, epididymal, and retroperitoneal WAT depots (SCAT, eWAT, and rpWAT, respectively) were removed for ex vivo experiments and Western blotting. SCAT, eWAT, and rpWAT from a subset of rats were also cultured separately and received a single in vitro HT or sham treatment. HSP72 and HSP25 expression was greatest in more metabolically active WAT depots (i.e., eWAT and rpWAT) compared with the SCAT. Following HT, HSP72 increased in all depots with the greatest induction occurring in the SCAT. In addition, HSP25 increased in the rpWAT and eWAT, while HSP60 increased in the rpWAT only in vivo. Free fatty acid (FFA) release from WAT explants was increased following HT in the rpWAT only, and fatty acid reesterification was decreased in the rpWAT but increased in the SCAT following HT. HT increased insulin responsiveness in eWAT, but not in SCAT or rpWAT. Differences in HSP expression and induction patterns following HT further support the growing body of literature differentiating distinct WAT depots in health and disease.

  17. Installation-restoration program. Phase 2. Confirmation/quantification. Stage 1 for Shaw Air Force Base, South Carolina. Final report, January 1984-October 1986

    SciTech Connect

    Alexander, W.J.; Liddle, S.K.

    1986-09-01

    The primary objectives of this project were to collect and analyze groundwater, surface water, and sediment samples and to perform an initial characterization of the hydrogeochemical regime at potential contamination sites on Shaw Air Force Base near Sumter, South Carolina. This study constituted Phase II of the U.S. Air Force Installation Restoration Program (IRP). Five potential sources of groundwater pollution were studied. The evaluation primarily included the drilling of soil test borings, the installation, development, and sampling of groundwater monitoring wells, and the analyses of soil, surface water, and groundwater samples. Also used in the study were field measurements of water quality, water-level measurements site observations, published hydrogeologic data and Shaw AFB documents.

  18. Society News: Welcome to Griffiths Bay; RAS Associate wins Shaw Prize; Postgraduate prize preparations; Council minutes on-line; Birthday Honours; Kavli Prize; New Fellows

    NASA Astrophysics Data System (ADS)

    2008-08-01

    The late Donald Griffiths will be commemorated in the name of a bay on the Antarctic Peninsula. Prof. Reinhard Genzel, Associate of the Society since 1994, Darwin Lecturer in 2007, and Director of the Max Planck Institute for Extraterrestrial Physics has been awarded the Shaw Prize in Astronomy for 2008. While postgrad students complete their PhD theses, supervisors should note the deadline for submissions to the annual Michael Penston and Keith Runcorn Prizes.

  19. A volume-of-fluid formulation for the study of co-flowing fluids governed by the Hele-Shaw equations

    NASA Astrophysics Data System (ADS)

    Afkhami, Shahriar; Renardy, Yuriko

    2013-08-01

    We present a computational framework to address the flow of two immiscible viscous liquids which co-flow into a shallow rectangular container at one side, and flow out into a holding container at the opposite side. Assumptions based on the shallow depth of the domain are used to reduce the governing equations to one of Hele-Shaw type. The distinctive feature of the numerical method is the accurate modeling of the capillary effects. A continuum approach coupled with a volume-of-fluid formulation for computing the interface motion and for modeling the interfacial tension in Hele-Shaw flows is formulated and implemented. The interface is reconstructed with a height-function algorithm. The combination of these algorithms is a novel development for the investigation of Hele-Shaw flows. The order of accuracy and convergence properties of the method are discussed with benchmark simulations. A microfluidic flow of a ribbon of fluid which co-flows with a second liquid is simulated. We show that for small capillary numbers of O(0.01), there is an abrupt change in interface curvature and focusing occurs close to the exit.

  20. Investigation and visualization of liquid-liquid flow in a vertically mounted Hele-Shaw cell: flow regimes, velocity and shape of droplets

    NASA Astrophysics Data System (ADS)

    Shad, S.; Gates, I. D.; Maini, B. B.

    2009-11-01

    The motion and shape of a liquid drop flowing within a continuous, conveying liquid phase in a vertical Hele-Shaw cell were investigated experimentally. The continuous phase was more viscous and wetted the bounding walls of the Hele-Shaw cell. The gap between the Hele-Shaw plates was set equal to 0.0226 cm. Four different flow regimes were observed: (a) small-droplet flow, (b) elongated-droplet flow, (c) churn flow and (d) channel flow. At low capillary number, that is, when capillary forces are larger than viscous forces, the droplet shape was irregular and changed with time and distance, and it moved with lower velocity than that of the conveying phase. At higher capillary number, several different shapes of stabilized elongated and flattened drops were observed. In contrast to gas-liquid systems, the velocities of droplets are higher than that of conveying liquid. New correlations derived from dimensionless analysis and fitted to the experimental data were generated to predict the elongated-drop velocity and aspect ratio.

  1. Alternative Fuels

    EPA Pesticide Factsheets

    Alternative fuels include gaseous fuels such as hydrogen, natural gas, and propane; alcohols such as ethanol, methanol, and butanol; vegetable and waste-derived oils; and electricity. Overview of alternative fuels is here.

  2. Fuel pin

    DOEpatents

    Christiansen, David W.; Karnesky, Richard A.; Leggett, Robert D.; Baker, Ronald B.

    1989-10-03

    A fuel pin for a liquid metal nuclear reactor is provided. The fuel pin includes a generally cylindrical cladding member with metallic fuel material disposed therein. At least a portion of the fuel material extends radially outwardly to the inner diameter of the cladding member to promote efficient transfer of heat to the reactor coolant system. The fuel material defines at least one void space therein to facilitate swelling of the fuel material during fission.

  3. Fuel pin

    DOEpatents

    Christiansen, David W.; Karnesky, Richard A.; Leggett, Robert D.; Baker, Ronald B.

    1989-01-01

    A fuel pin for a liquid metal nuclear reactor is provided. The fuel pin includes a generally cylindrical cladding member with metallic fuel material disposed therein. At least a portion of the fuel material extends radially outwardly to the inner diameter of the cladding member to promote efficient transfer of heat to the reactor coolant system. The fuel material defines at least one void space therein to facilitate swelling of the fuel material during fission.

  4. Fuel pin

    DOEpatents

    Christiansen, D.W.; Karnesky, R.A.; Leggett, R.D.; Baker, R.B.

    1987-11-24

    A fuel pin for a liquid metal nuclear reactor is provided. The fuel pin includes a generally cylindrical cladding member with metallic fuel material disposed therein. At least a portion of the fuel material extends radially outwardly to the inner diameter of the cladding member to promote efficient transfer of heat to the reactor coolant system. The fuel material defines at least one void space therein to facilitate swelling of the fuel material during fission.

  5. Fuel pin

    SciTech Connect

    Christiansen, D.W.; Karnesky, R.A.; Leggett, R.D.; Baker, R.B.

    1987-11-24

    A fuel pin for a liquid metal nuclear reactor is provided. The fuel pin includes a generally cylindrical cladding member with metallic fuel material disposed therein. At least a portion of the fuel material extends radially outwardly to the inner diameter of the cladding member to promote efficient transfer of heat to the reactor coolant system. The fuel material defines at least one void space therein to facilitate swelling of the fuel material during fission.

  6. Indication of metal homeostasis disturbance in earthworm Eisenia fetida after exposure to semi-solid depot sludge.

    PubMed

    Babić, Sanja; Dragun, Zrinka; Sauerborn Klobučar, Roberta; Ivanković, Dušica; Bačić, Niko; Fiket, Željka; Barišić, Josip; Krasnići, Nesrete; Strunjak-Perović, Ivančica; Topić Popović, Natalija; Čož-Rakovac, Rozelindra

    2015-09-01

    Treated sewage sludge is commonly used in agriculture as fertilizer. It is, therefore, necessary to determine possible detrimental influences of sludge application on soil contamination and accumulation of contaminants in tissues of terrestrial animals, which in the long run could also have undesirable effects on humans. With that aim, the study was performed using earthworm Eisenia fetida as test organism and semi-solid depot sludge from a wastewater treatment plant as exposure media. The concentrations of 26 metals/metalloids were determined in depot sludge, and their bioaccumulation was estimated in whole tissue of E. fetida, and for the first time in the soluble tissue fraction, which represents metal fraction available for metabolic requirements and toxic effects. Obtained results have revealed acceptable levels of several elements (Cd, Cr, Cu, Ni, Pb, Zn) in depot sludge, when compared to currently valid regulations, and only moderate accumulation of some elements (e.g. As, Ba, Cd, Co, Fe, Tl, V, and Zn) in earthworms, as a consequence of exposure to depot sludge. However, a concentration increase after exposure to depot sludge was observed in E. fetida for several elements (Cd, Mo, and Zn), which were present in lower concentrations in the exposure mixtures than in soil. Contrary, a concentration decrease was observed for Cs, Mn, and Rb, although they were present in higher concentrations in depot sludge than in soil. It was an indication of disturbance in metal homeostasis in earthworms, possibly caused by exposure to complex mixture of contaminants present in depot sludge. The cumulative effect of exposure to a number of various contaminants (inorganic, organic, microbiological and pharmaceutical), even if each of them was not present in very high concentrations, could have caused distress in earthworms exposed to depot sludge. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Health assessment for Anniston Army Depot, Bynum, Calhoun County, Alabama, Region 4. CERCLIS No. AL3210020027. Preliminary report

    SciTech Connect

    Not Available

    1989-04-29

    The Anniston Army Depot (ANAD) facility, which occupies 15,200 acres in northeast Alabama, was originally an ammunition storage depot. Contaminants of concern include trichloroethylene (TCE), cis- and trans-dichloroethylene, methylene chloride, metals, and phenol in groundwater. Based on the available information, the site is considered to be of potential public health concern because of the risk to human health caused by the possibility of exposure to hazardous substances.

  8. Organic Versus Contractor Logistics Support For Depot-Level Repair: Factors That Drive Sub-Optimal Decisions

    DTIC Science & Technology

    2016-02-16

    AIR WAR COLLEGE AIR UNIVERSITY ORGANIC VERSUS CONTRACTOR LOGISTICS SUPPORT FOR DEPOT-LEVEL REPAIR: FACTORS THAT DRIVE SUB-OPTIMAL...depot maintenance will supported organically by the government or rely on Contractor Logistics Support (CLS). The consequences of this decision are...weapons system organically or through CLS. This paper reviews the policy, laws, and factors that the Program Manager (PM) must consider when selecting

  9. Planning Documents Known Releases SWMUs Tooele Army Depot Tooele, Utah. Volume 1: Corrective Measures Study Work Plan

    DTIC Science & Technology

    2000-02-01

    SECOND REVISED FINAL DET:-, PLANNING DOCUMENTS KNOWN RELEASES SWMUs TOOELE ARMY DEPOT TOOELE, UTAH Volume I: CORRECTIVE MEASURES STUDY WORK PLAN...FINAL PLANNING DOCUMENTS KNOWN RELEASES SWMUs TOOELE ARMY DEPOT TOOELE, UTAH Volume I: CORRECTIVE MEASURES STUDY WORK PLAN Contract DACA31-94-D-0060...2-1 3.0 X-RAY LAGOON (SWMU 3) ..................................................................... 3-1 3.1 SWMU BACKGROUND

  10. Breeding biology of the spotted salamander Ambystoma maculatum (Shaw) in acidic temporary ponds at Cape Cod, USA

    USGS Publications Warehouse

    Portnoy, J.W.

    1990-01-01

    The relationship between water chemistry and breeding success of spotted salamanders Ambystoma maculatum (Shaw) was examined in temporary woodland ponds on outer Cape Cod, Massachusetts in 1985 and 1986. Most pond waters were dilute (3median coductivity = 57 umhos cm-1 (1 umhos cm-1 = 0?1 mSm-1)), acidic (median pH = 4?82), and highly colored (median = 140 Pt-Co units). Most acidity was due to abundant organic acids. Salamander survival to hatching was over 80% at 8 of 12 ponds monitored. Complete mortality, preceded by gross abnormalities, was observed only among embryos in the most acidic spawning pond (pH 4?3-4?5) in both years. Embryo transfers between ponds and laboratory studies indicated that reduced survival was due to the interaction of low pH with high tannin-lignin concentration. The use of amphibian embryonic survival to indicate acid rain effects is complicated by multiple habitat parameters and should only be attempted in conjunction with long-term population monitoring.

  11. Effects of testosterone on contractile properties of sexually dimorphic forelimb muscles in male bullfrogs (Rana catesbeiana, Shaw 1802)

    PubMed Central

    Kampe, Aaron R.; Peters, Susan E.

    2013-01-01

    Summary This study examined the effects of testosterone (T) on the contractile properties of two sexually dimorphic forelimb muscles and one non-dimorphic muscle in male bullfrogs (Rana catesbeiana, Shaw 1802). The dimorphic muscles in castrated males with testosterone replacement (T+) achieved higher forces and lower fatigability than did castrated males without replaced testosterone (T0 males), but the magnitude of the differences was low and many of the pair-wise comparisons of each muscle property were not statistically significant. However, when taken as a whole, the means of seven contractile properties varied in the directions expected of masculine values in T+ animals in the sexually dimorphic muscles. Moreover, these data, compared with previous data on male and female bullfrogs, show that values for T+ males are similar to normal males and are significantly different from females. The T0 males tended to be intermediate in character between T+ males and females, generally retaining masculine values. This suggests that the exposure of young males to T in their first breeding season produces a masculinizing effect on the sexually dimorphic muscles that is not reversed between breeding seasons when T levels are low. The relatively minor differences in contractile properties between T+ and T0 males may indicate that as circulating T levels rise during breeding season in normal males, contractile properties can be enhanced rapidly to maximal functional levels for breeding success. PMID:24143280

  12. Cross-diffusion-driven gravitational instability in a Hele-Shaw cell saturated with a ternary solution

    NASA Astrophysics Data System (ADS)

    Kim, Min Chan; Song, Kwang Ho

    2016-08-01

    The effect of cross diffusion on the onset of the gravitational instabilities in a Hele-Shaw cell saturated with a ternary solution is analyzed. Based on the linear stability theory, new stability equations are derived in the global domain and then transformed into the similar domain. These stability equations are solved by employing various methods such as an initial value problem approach and quasi-steady state approximations (QSSA's). Through the initial growth rate analysis without the QSSA, we prove that initially the system is unconditionally stable. However, the QSSA in the global domain showed that the system can be initially unstable for a certain condition. Based on the QSSA in the similar domain (QSSAζ), we obtain the critical time for the onset of instability motion. As expected, the higher |" separators=" δ 21 β | makes the system more unstable, i.e., accelerates the onset of instability motion; here δ21 and β represent the normalized cross diffusion coefficient and the ratio of densification coefficients, respectively. Based on the linear analysis, fully nonlinear analyses are also conducted by using the Fourier spectral method. The present nonlinear analyses show that the double-diffusive and diffusive-layer convection-type of instabilities are possible for the positive and negative δ21β-values, respectively. From the present nonlinear analysis, the system having δ22 > 1 prefers the instabilities with a larger wavelength than the system having δ22 < 1. Here δ22 is the normalized normal diffusion coefficient of component B.

  13. A well-posed numerical method to track isolated conformal map singularities in Hele-Shaw flow

    NASA Technical Reports Server (NTRS)

    Baker, Gregory; Siegel, Michael; Tanveer, Saleh

    1995-01-01

    We present a new numerical method for calculating an evolving 2D Hele-Shaw interface when surface tension effects are neglected. In the case where the flow is directed from the less viscous fluid into the more viscous fluid, the motion of the interface is ill-posed; small deviations in the initial condition will produce significant changes in the ensuing motion. This situation is disastrous for numerical computation, as small round-off errors can quickly lead to large inaccuracies in the computed solution. Our method of computation is most easily formulated using a conformal map from the fluid domain into a unit disk. The method relies on analytically continuing the initial data and equations of motion into the region exterior to the disk, where the evolution problem becomes well-posed. The equations are then numerically solved in the extended domain. The presence of singularities in the conformal map outside of the disk introduces specific structures along the fluid interface. Our method can explicitly track the location of isolated pole and branch point singularities, allowing us to draw connections between the development of interfacial patterns and the motion of singularities as they approach the unit disk. In particular, we are able to relate physical features such as finger shape, side-branch formation, and competition between fingers to the nature and location of the singularities. The usefulness of this method in studying the formation of topological singularities (self-intersections of the interface) is also pointed out.

  14. Rayleigh-Taylor instabilities in reaction-diffusion systems inside Hele-Shaw cell modified by the action of temperature.

    PubMed

    García Casado, Gustavo; Tofaletti, Lorena; Müller, Darío; D'Onofrio, Alejandro

    2007-03-21

    The influence of temperature in the buoyancy driven Rayleigh-Taylor instability of reaction-diffusion fronts is investigated experimentally in Hele-Shaw cells. The acid autocatalysis of chlorite-tetrathionate reaction coupled to molecular diffusion yields exothermic planar reaction-diffusion fronts separating two miscible reactant and product solutions. The resulting chemical front moves downwards invading the fresh reactants, leaving the products of the reaction behind it. The density of the product solution is higher than the reactant solution; hence, the traveling front is buoyantly unstable and develops density fingers in time (Rayleigh-Taylor instability) when the products are above the reactants. The kinetic constant of a chemical reaction varies due to thermal effects. This may stabilize the exothermic descending front when temperature is increased, so that the mixing zone decreases, modifying the fingering patterns, until it almost disappears. The authors study the influence of the temperature variation on the instability pattern figure observed in the chlorite-tetrathionate reaction for long times, corresponding to the nonlinear regime.

  15. Bubble contraction in free-boundary Hele-Shaw flow with surface tension and kinetic undercooling regularisation

    NASA Astrophysics Data System (ADS)

    Dallaston, Michael; McCue, Scott

    2012-11-01

    When an inviscid bubble expands into a viscous fluid in a Hele-Shaw cell, the bubble boundary is unstable, in general forming long fingers (the Saffman-Taylor instability). In order to make the problem well-posed, a regularising boundary effect must be included. The most widely studied of these are surface tension, which penalises high curvatures, and kinetic undercooling, which penalises high velocities. Both these effects act as a stabilising influence on the free boundary. Less attention has been paid to the case of contracting bubbles, which shrink to a single point (or points) in finite time. In this case, the two effects are in competition, as surface tension stabilises the boundary, while kinetic undercooling destabilises it. This leads to bifurcation behaviour in the asymptotic (near-extinction) shape of the bubble as the relative strengths of the two effects are varied. In particular, there is a critical range of parameter values for which both circular and slit-type bubbles are stable, with a third (unstable) oval-type shape also present. We discuss some numerical and analytic techniques for solving the full free boundary problem and for exploring this interesting extinction behaviour.

  16. Rayleigh-Taylor instabilities in reaction-diffusion systems inside Hele-Shaw cell modified by the action of temperature

    NASA Astrophysics Data System (ADS)

    García Casado, Gustavo; Tofaletti, Lorena; Müller, Darío; D'Onofrio, Alejandro

    2007-03-01

    The influence of temperature in the buoyancy driven Rayleigh-Taylor instability of reaction-diffusion fronts is investigated experimentally in Hele-Shaw cells. The acid autocatalysis of chlorite-tetrathionate reaction coupled to molecular diffusion yields exothermic planar reaction-diffusion fronts separating two miscible reactant and product solutions. The resulting chemical front moves downwards invading the fresh reactants, leaving the products of the reaction behind it. The density of the product solution is higher than the reactant solution; hence, the traveling front is buoyantly unstable and develops density fingers in time (Rayleigh-Taylor instability) when the products are above the reactants. The kinetic constant of a chemical reaction varies due to thermal effects. This may stabilize the exothermic descending front when temperature is increased, so that the mixing zone decreases, modifying the fingering patterns, until it almost disappears. The authors study the influence of the temperature variation on the instability pattern figure observed in the chlorite-tetrathionate reaction for long times, corresponding to the nonlinear regime.

  17. CDC recommendations for civilian communities near chemical weapons depots: guidelines for medical preparedness--CDC. Publication of final recommendations.

    PubMed

    1995-06-27

    On July 27, 1994, CDC published in the Federal Register, 59 FR 38191, "CDC Recommendations for Civilian Communities Near Chemical Weapons Depots: Guidelines for Medical Preparedness" and requested public comment. Seven people sent comments; many were responding on behalf of governments or other institutions in affected communities. These comments are available upon request. These recommendations incorporate changes made in response to the comments received and constitutes CDC's final recommendations for minimum standards for prehospital and hospital emergency medical services' readiness in communities near the eight locations where the U.S. stockpile of lethal chemical weapons is stored. The eight locations are: Umatilla Army Depot Activity, Oregon; Tooele Army Depot, Utah; Pueblo Army Depot Activity, Colorado; Pine Bluff Arsenal, Arkansas; Newport Army Ammunition Plant, Indiana; Anniston Army Depot, Alabama; Lexington Bluegrass Depot Activity, Kentucky; and Edgewood Area, Aberdeen Proving Ground, Maryland. These recommendations were prepared to assist emergency planners in determining emergency medical services' readiness in communities near the 8 locations where the U.S. stockpile of lethal chemical weapons is stored. These guidelines should not be used for any purpose other than planning for the Chemical Stockpile Emergency Preparedness Program.

  18. Gluteal and abdominal subcutaneous adipose tissue depots as stroma cell source: gluteal cells display increased adipogenic and osteogenic differentiation potentials.

    PubMed

    Iwen, Karl Alexander; Priewe, Anna-Christin; Winnefeld, Marc; Rose, Christian; Siemers, Frank; Rohwedel, Jürgen; Cakiroglu, Figen; Lehnert, Hendrik; Schepky, Andreas; Klein, Johannes; Kramer, Jan

    2014-06-01

    Human adipose-derived stroma cells (ADSCs) have successfully been employed in explorative therapeutic studies. Current evidence suggests that ADSCs are unevenly distributed in subcutaneous adipose tissue; therefore, the anatomical origin of ADSCs may influence clinical outcomes. This study was designed to investigate proliferation and differentiation capacities of ADSCs from the gluteal and abdominal depot of 8 females. All had normal BMI (22.01 ± 0.39 kg/m(2) ) and waist circumference (81.13 ± 2.33 cm). Examination by physicians and analysis of 31 laboratory parameters did not reveal possibly confounding medical disorders. Gluteal and abdominal adipose tissue was sampled by en bloc resection on day 7 (±1) after the last menses. Histological examination did not reveal significant depot-specific differences. As assessed by BrdU assay, proliferation of cells from both depots was similar after 24 h and analysis of 15 cell surface markers by flow cytometry identified the isolated cells as ADSCs, again without depot-specific differences. ADSCs from both depots differentiated poorly to chondroblasts. Gluteal ADSCs displayed significantly higher adipogenic differentiation potential than abdominal cells. Osteogenic differentiation was most pronounced in gluteal cells, whereas differentiation of abdominal ADSCs was severely impaired. Our data demonstrate a depot-specific difference in ADSC differentiation potential with abdominal cells failing to meet the criteria of multipotent ADSCs. This finding should be taken into account in future explorations of ADSC-derived therapeutic strategies.

  19. Differential sympathetic outflow to adipose depots is required for visceral fat loss in response to calorie restriction

    PubMed Central

    Sipe, L M; Yang, C; Ephrem, J; Garren, E; Hirsh, J; Deppmann, C D

    2017-01-01

    The sympathetic nervous system (SNS) regulates energy homeostasis in part by governing fatty acid liberation from adipose tissue. We first examined whether SNS activity toward discrete adipose depots changes in response to a weight loss diet in mice. We found that SNS activity toward each adipose depot is unique in timing, pattern of activation, and habituation with the most dramatic contrast between visceral and subcutaneous adipose depots. Sympathetic drive toward visceral epididymal adipose is more than doubled early in weight loss and then suppressed later in the diet when weight loss plateaued. Coincident with the decline in SNS activity toward visceral adipose is an increase in activity toward subcutaneous depots indicating a switch in lipolytic sources. In response to calorie restriction, SNS activity toward retroperitoneal and brown adipose depots is unaffected. Finally, pharmacological blockage of sympathetic activity on adipose tissue using the β3-adrenergic receptor antagonist, SR59230a, suppressed loss of visceral adipose mass in response to diet. These findings indicate that SNS activity toward discrete adipose depots is dynamic and potentially hierarchical. This pattern of sympathetic activation is required for energy liberation and loss of adipose tissue in response to calorie-restricted diet. PMID:28394360

  20. Fifteen Years of Web Based Data Management at Tooele Army Depot

    DTIC Science & Technology

    2012-03-28

    And, Tooele Army Depot Goes Online Following an EPA audit of nine federal  facilities, Tooele Army Depot ( TEAD )  proactively begins the process of...District contracted with  Synectics to provide an innovative solution  allowing  TEAD  stakeholders to access the same  data the prime contractor was...Ellin, do you know llle project Suzan Hughes document for Parson’s TEAD SVYMU-58 Certified All the Data in One Place Laboratories & Contractors Legend

  1. [Preauricular injection of betamethasone depot and acyclovir for the treatment of acute herpes zoster ophthalmicus].

    PubMed

    Arenas-Archila, E; Alvizu, F; Muñoz-Sarmiento, D

    2015-04-01

    Several treatments have been described for the management of patients with herpes zoster ophthalmicus (HZO). However, the progress of these patients is usually slow, and many of them develop postherpetic neuritis (PHN). In the present paper, three clinical cases are presented, in which a significant symptomatic improvement was obtained by using a preauricular injection of a mixture of betamethasone depot combined with acyclovir. PHN did not develop in any of them. The preauricular injection of betamethasone depot and acyclovir could be a good alternative for the management of HZO. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  2. Optimizing the Shunting Schedule of Electric Multiple Units Depot Using an Enhanced Particle Swarm Optimization Algorithm.

    PubMed

    Wang, Jiaxi; Lin, Boliang; Jin, Junchen

    2016-01-01

    The shunting schedule of electric multiple units depot (SSED) is one of the essential plans for high-speed train maintenance activities. This paper presents a 0-1 programming model to address the problem of determining an optimal SSED through automatic computing. The objective of the model is to minimize the number of shunting movements and the constraints include track occupation conflicts, shunting routes conflicts, time durations of maintenance processes, and shunting running time. An enhanced particle swarm optimization (EPSO) algorithm is proposed to solve the optimization problem. Finally, an empirical study from Shanghai South EMU Depot is carried out to illustrate the model and EPSO algorithm. The optimization results indicate that the proposed method is valid for the SSED problem and that the EPSO algorithm outperforms the traditional PSO algorithm on the aspect of optimality.

  3. Optimizing the Shunting Schedule of Electric Multiple Units Depot Using an Enhanced Particle Swarm Optimization Algorithm

    PubMed Central

    Jin, Junchen

    2016-01-01

    The shunting schedule of electric multiple units depot (SSED) is one of the essential plans for high-speed train maintenance activities. This paper presents a 0-1 programming model to address the problem of determining an optimal SSED through automatic computing. The objective of the model is to minimize the number of shunting movements and the constraints include track occupation conflicts, shunting routes conflicts, time durations of maintenance processes, and shunting running time. An enhanced particle swarm optimization (EPSO) algorithm is proposed to solve the optimization problem. Finally, an empirical study from Shanghai South EMU Depot is carried out to illustrate the model and EPSO algorithm. The optimization results indicate that the proposed method is valid for the SSED problem and that the EPSO algorithm outperforms the traditional PSO algorithm on the aspect of optimality. PMID:27436998

  4. Understanding of empty container movement: A study on a bottleneck at an off-dock depot

    NASA Astrophysics Data System (ADS)

    Zain, Rosmaizura Mohd; Rahman, Mohd Nizam Ab; Nopiah, Zulkifli Mohd; Saibani, Nizaroyani

    2014-09-01

    Port not only function as connections between marine and land transportation but also as core business areas. In a port terminal, available space is limited, but the influx of container is growing. The off-dock depot is one of the key supply chain players that hold empty containers in the inventory. Therefore, this paper aims to identify the main factors of bottlenecks or congestion that hinder the rapid movement of empty containers from the off-dock depot to the customers. Thirty interviews were conducted with individuals who are key players in the container supply chain. The data were analyzed using Atlas.ti software and the analytic hierarchy process to rank the priority factors of bottlenecks. Findings show that several pertinent factors act as barriers to the key players in the container movement in the day-to-day operations. In future studies, strategies to overcome fragmentation in the container supply chain and logistics must be determined.

  5. Leuprorelin depot injection: patient considerations in the management of prostatic cancer

    PubMed Central

    Abouelfadel, Zinelabidine; Crawford, E David

    2008-01-01

    Hormone therapy is well established for treating patients with prostate cancer and remains the mainstay of the treatment of metastatic and locally advanced disease, this article reviews the rationale for its use, its different forms, and complications and controversies still surrounding some of its modalities. Availability of long-acting synthetic luteinizing hormone-releasing hormone (LHRH) agonists revolutionized the hormonal treatment of prostate cancer, and helped to avoid the emotional and psychological effects related to surgical castration. The depot formula has gained wide acceptance from both patients and physicians. This review emphasizes the newer, long-acting formula, leuprorelin (leuprolide acetate), especially the 6-month formula, its advantage over over shorter-acting depot products, and its potential to become a standard of care for patients eligible for androgen deprivation therapy. PMID:18728847

  6. Different adipose tissue depots: Metabolic implications and effects of surgical removal.

    PubMed

    Marcadenti, Aline; de Abreu-Silva, Erlon Oliveira

    2015-11-01

    Increased adiposity has been associated to worse metabolic profile, cardiovascular disease, and mortality. There are two main adipose tissue depots in the body, subcutaneous and visceral adipose tissue, which differ in anatomical location. A large body of evidence has shown the metabolic activity of adipose tissue; lipectomy and/or liposuction therefore appear to be alternatives for improving metabolic profile through rapid loss of adipose tissue. However, surgical removal of adipose tissue may be detrimental for metabolism, because subcutaneous adipose tissue has not been associated to metabolic disorders such as insulin resistance and type 2 diabetes mellitus. In addition, animal studies have shown a compensatory growth of adipose tissue in response to lipectomy. This review summarizes the implications of obesity-induced metabolic dysfunction, its relationship with the different adipose tissue depots, and the effects of lipectomy on cardiometabolic risk factors. Copyright © 2015 SEEN. Published by Elsevier España, S.L.U. All rights reserved.

  7. Fuel pump

    SciTech Connect

    Bellis, P.D.; Nesselrode, F.

    1991-04-16

    This patent describes a fuel pump. It includes: a fuel reservoir member, the fuel reservoir member being formed with fuel chambers, the chambers comprising an inlet chamber and an outlet chamber, means to supply fuel to the inlet chamber, means to deliver fuel from the outlet chamber to a point of use, the fuel reservoir member chambers also including a bypass chamber, means interconnecting the bypass chamber with the outlet chamber; the fuel pump also comprising pump means interconnecting the inlet chamber and the outlet chamber and adapted to suck fuel from the fuel supply means into the inlet chamber, through the pump means, out the outlet chamber, and to the fuel delivery means; the bypass chamber and the pump means providing two substantially separate paths of fuel flow in the fuel reservoir member, bypass plunger means normally closing off the flow of fuel through the bypass chamber one of the substantially separate paths including the fuel supply means and the fuel delivery means when the bypass plunger means is closed, the second of the substantially separate paths including the bypass chamber when the bypass plunger means is open, and all of the chambers and the interconnecting means therebetween being configured so as to create turbulence in the flow of any fuel supplied to the outlet chamber by the pump means and bypassed through the bypass chamber and the interconnecting means.

  8. A Review of Reverse Logistics and Depot Level Repairable Tracking in the United States Navy

    DTIC Science & Technology

    2005-06-01

    Repairable Tracking in the United States Navy By: Edward L. Stevenson, Cane A. Toussaint, and Mark A. Edwards June 2005 Advisors...Report 4. TITLE AND SUBTITLE: A Review of Reverse Logistics and Depot Level Repairable Tracking in the United States Navy 6. AUTHOR(S) Edward L...Stevenson, Cane A. Toussaint, and Mark A. Edwards 5. FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School

  9. Depot Maintenance: Improvements to DODs Biennial Core Report Could Better Inform Oversight and Funding Decisions

    DTIC Science & Technology

    2016-11-01

    facilities, equipment, processes, and technology . Section 2464 requires DOD to provide a Biennial Core Report to Congress that includes information for the...equipment, processes, and technology for each category of maintenance work being done. Recognizing the important role of the depots in supporting U.S...and technologies known as work breakdown structure categories. The work breakdown structure category is a grouping of work associated with DOD’s

  10. Tooele Army Depot-North Area Suspected Releases SWMUs. Phase 1 RFI report. Volume 1. Text

    DTIC Science & Technology

    1993-12-01

    location of the continental storm track , most of the precipitation in the Tooele Valley occurs as snow between the months of October and May. Summers are...of railroad tracks . Stormwater from the Administration Area drains via an underground concrete piping system to a depression in a dry wash, where it...Shank (JMM) with Ammunition survelliance Chief, Milo Serreyn, Tooele Army Depot, Utah, October 1992. Siniscalchi, 1991. Telephone interview conducted

  11. Using Depot Inventory Position to Determine Transportation Mode of Retrograde Reparable Assets

    DTIC Science & Technology

    2005-03-01

    Goldratt , Eliyahu M. The Goa (Second Edition). Great Barrington MA. The North River Press, 1992. Hall, Patricia K. and Paul R. Murphy. “The...could be used as a factor and shows the serviceable inventory could prove useful as well. 46 In his book The Goal, Eli Goldratt (1992) suggests...process, as this will just waste resources and not speed up the system ( Goldratt , 1992). If the depot is considered the bottleneck based on its

  12. Monotherapy with lanreotide depot for acromegaly: long-term clinical experience in a pituitary center.

    PubMed

    Sagvand, Babak Torabi; Khairi, Shafaq; Haghshenas, Arezoo; Swearingen, Brooke; Tritos, Nicholas A; Miller, Karen K; Klibanski, Anne; Nachtigall, Lisa B

    2016-08-01

    Long-acting somatostatin analogs are one of the main classes of medical therapy used for acromegaly and most patients require ongoing treatment. Few studies have evaluated the long-term efficacy and safety of lanreotide depot beyond 2 years. The goal of this study was to provide a long-term longitudinal assessment of efficacy and safety of lanreotide depot in lanreotide responders compared to a surgically cured control group. In this retrospective longitudinal case-control study, patients with acromegaly receiving lanreotide depot monotherapy continuously for at least 24 months (N = 24) and surgically cured patients (N = 39) were compared. Serum IGF-1, pituitary MRIs, lanreotide dose, co-morbidities and adverse effects were assessed longitudinally. In the lanreotide group, IGF-1 remained normal and unchanged over 6 years; comparable to the surgery only group. There was no difference in prevalence of normal IGF-1 between the lanreotide and surgery only groups at 6 months (100 vs. 97 %), 6 years (89 vs. 90 %) and at last follow-up (96 vs. 92 %). Tumor size remained stable (79 %) or decreased (21 %) in the lanreotide group. In the surgery only group, tumor size remained unchanged in all patients. Hemoglobin A1C did not differ between lanreotide and surgery only groups (baseline 5.8 vs. 6.1 %; last follow-up 6.0 vs. 5.7 %). Two (8 %) of the lanreotide and none of the surgery only group developed new diabetes mellitus. Lanreotide depot maintains normalization of IGF-1 in 89 % of responders after 6 years, comparable to surgically cured controls, and controlled tumor size in all without significant adverse effects.

  13. Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research

    PubMed Central

    Dodson, Michael V.; Hausman, Gary J.; Guan, LeLuo; Du, Min; Rasmussen, Theodore P.; Poulos, Sylvia P.; Mir, Priya; Bergen, Werner G.; Fernyhough, Melinda E.; McFarland, Douglas C.; Rhoads, Robert P.; Soret, Beatrice; Reecy, James M.; Velleman, Sandra G.; Jiang, Zhihua

    2010-01-01

    Meat animals are unique as experimental models for both lipid metabolism and adipocyte studies because of their direct economic value for animal production. This paper discusses the principles that regulate adipogenesis in major meat animals (beef cattle, dairy cattle, and pigs), the definition of adipose depot-specific regulation of lipid metabolism or adipogenesis, and introduces the potential value of these animals as models for metabolic research including mammary biology and the ontogeny of fatty livers. PMID:21103072

  14. An Archeological Overview and Management Plan for Tooele Army Depot North and South

    DTIC Science & Technology

    1984-03-29

    is located in the northeast corner of the Depot.- Aside from CAMUS , this is the major activity area on the South Post. The developed portion, located... Albert Sidney Johnston, the officer in charge of an 1857 expedition to Utah, was instructed to find a suitable location for a permanent post near Salt...City: State of Utah. Department of Natural resources, Technical Publication No. 69.* Reagan, Albert B. 1934a. The Shoshone-Gosiute (Goshute), or

  15. Control of Adipocyte Differentiation in Different Fat Depots; Implications for Pathophysiology or Therapy

    PubMed Central

    Ma, Xiuquan; Lee, Paul; Chisholm, Donald J.; James, David E.

    2015-01-01

    Adipocyte differentiation and its impact on restriction or expansion of particular adipose tissue depots have physiological and pathophysiological significance in view of the different functions of these depots. Brown or “beige” fat [brown adipose tissue (BAT)] expansion can enhance thermogenesis, lipid oxidation, insulin sensitivity, and glucose tolerance; conversely expanded visceral fat [visceral white adipose tissue (VAT)] is associated with insulin resistance, low grade inflammation, dyslipidemia, and cardiometabolic risk. The largest depot, subcutaneous white fat [subcutaneous white adipose tissue (SAT)], has important beneficial characteristics including storage of lipid “out of harms way” and secretion of adipokines, especially leptin and adiponectin, with positive metabolic effects including lipid oxidation, energy utilization, enhanced insulin action, and an anti-inflammatory role. The absence of these functions in lipodystrophies leads to major metabolic disturbances. An ability to expand white adipose tissue adipocyte differentiation would seem an important defense mechanism against the detrimental effects of energy excess and limit harmful accumulation of lipid in “ectopic” sites, such as liver and muscle. Adipocyte differentiation involves a transcriptional cascade with PPARγ being most important in SAT but less so in VAT, with increased angiogenesis also critical. The transcription factor, Islet1, is fairly specific to VAT and in vitro inhibits adipocyte differentiation. The physiological importance of Islet1 requires further study. Basic control of differentiation is similar in BAT but important differences include the effect of PGC-1α on mitochondrial biosynthesis and upregulation of UCP1; also PRDM16 plays a pivotal role in expression of the BAT phenotype. Modulation of the capacity or function of these different adipose tissue depots, by altering adipocyte differentiation or other means, holds promise for interventions that can be

  16. Evidence for Environmental Contamination in Residential Neighborhoods Surrounding the Defense Depot of Memphis, Tennessee

    PubMed Central

    Greene, Natasha A.; White, Jason D.; Morris, Vernon R.; Roberts, Stephanie; Jones, Kimberly L.; Warrick, Cynthia

    2006-01-01

    An interdisciplinary environmental assessment team from the Howard University Environmental Justice Partnership (HUEJP) conducted a site visit and assessment of the Defense Depot of Memphis, Tennessee in February of 2000. This depot was built in the late 1940’s for storage of numerous chemicals and munitions. As the years progressed, many Memphis citizens have grown to believe that the activities and chemical stockpile located at this site have negatively affected the health environment of their residents. There is anecdotal evidence and documentation of numerous cancers and other illnesses in those local territories, and specifically, at the Memphis Depot site. Currently, this depot is closed and in remediation by the local government. Particularly, citizens of the Rozelle community have started a campaign to investigate any signs of exposure pathways to noted health risks. The HUEJP was contacted and asked to investigate the community concerns. Obliging to the request, we aimed to sample at three drainage sites and a residential site, talk to local citizens, and gain any additional information that would be helpful in relieving anxiety in the Rozelle community. Soil, sediment, and water samples were collected and analyzed for total organic carbon, inorganic anions, and heavy metals. These data show that for the four sites sampled, the highest concentrations of organic compounds and heavy metals were located either within a residential area or in an area with a direct transport pathway to the community. Atomic absorption analysis revealed detectable amounts of cadmium, lead and chromium metals at all sites with direct transport pathways into the residential community, with chromium concentrations being far in excess of the EPA standard limits. PMID:16968970

  17. Extending Depot Length and Intervals for DDG 51 Class Ships: Examining the 72 Month Operational Cycle

    DTIC Science & Technology

    2016-01-01

    Extending Depot Length and Intervals for DDG-51-Class Ships Examining the 72- Month Operational Cycle Roland J. Yardley, Daniel Tremblay, Brian...to a 36- month Optimized Fleet Response Plan operational cycle. However, with the constrained budget environment, the Navy is evaluating how best to...Class Ships: The 72- Month Cycle removal of the crew during the execution of maintenance to mitigate costs in this employment approach. This research

  18. Long-acting injectable risperidone: safety and efficacy in stable patients switched from conventional depot antipsychotics.

    PubMed

    Turner, Martin; Eerdekens, Els; Jacko, Mary; Eerdekens, Mariëlle

    2004-07-01

    Long-acting injectable risperidone was assessed in schizophrenia patients who were symptomatically stable on conventional depot antipsychotics and who were then switched to long-acting risperidone. Participants in this open-label, multicentre, 12-week trial had received flupenthixol decanoate, fluphenazine decanoate, haloperidol decanoate, or zuclopenthixol decanoate for 4 months or longer. Each was considered symptomatically stable by investigators. After receiving two cycles of their conventional depot antipsychotic during the run-in period, patients were switched to receive long-acting risperidone every 2 weeks for 12 weeks at an initial dose of 25 mg. This dose could be increased in 12.5-mg increments at 4-week intervals. Ninety-two percent of the patients received all six injections; 62% received the 25-mg dose throughout the treatment period. Adverse events related to movement disorders were reported in 3%. Severity of movement disorders decreased during long-acting risperidone treatment. Positive and Negative Syndrome Scale (PANSS) total and factor scores and scores on the Clinical Global Impressions severity scale were significantly reduced during treatment; 48% of these stable patients showed further symptom improvement (> or =20% decrease in PANSS score at endpoint). The results indicate that patients with schizophrenia who are symptomatically stable during treatment with a conventional depot antipsychotic can be safely and effectively switched to long-acting injectable risperidone without a prior transition to oral risperidone.

  19. Adipose tissue depot specific differences of PLIN protein content in endurance trained rats

    PubMed Central

    Ramos, Sofhia V.; Turnbull, Patrick C.; MacPherson, Rebecca E. K.

    2016-01-01

    ABSTRACT Adipose tissue is classified as either white (WAT) or brown (BAT) and differs not only by anatomical location but also in function. WAT is the main source of stored energy and releases fatty acids in times of energy demand, whereas BAT plays a role in regulating non-shivering thermogenesis and oxidizes fatty acids released from the lipid droplet. The PLIN family of proteins has recently emerged as being integral in the regulation of fatty acid storage and release in adipose tissue. Previous work has demonstrated that PLIN protein content varies among adipose tissue depots, however an examination of endurance training-induced depot specific changes in PLIN protein expression has yet to be done. Male Sprague-dawley rats (n = 10) underwent 8-weeks of progressive treadmill training (18–25 m/min for 30–60 min at 10% incline) or remained sedentary as control. Following training, under isoflurane induced anesthesia epidydmal (eWAT), inguinal subcutaneous (iWAT) and intrascapular brown adipose tissue (BAT) was excised, and plasma was collected. Endurance training resulted in an increase in BAT PLIN5 and iWAT PLIN3 content, while there was no difference in PLIN protein content in endurance trained eWAT. Interestingly, endurance training resulted in a robust increase in ATGL and CGI-58 in eWAT alone. Together these results suggest the potential of a depot specific function of PLIN3 and PLIN5 in adipose tissue in response to endurance training. PMID:27386161

  20. Antipsychotic agents. Gradually improving treatment from the traditional oral neuroleptics to the first atypical depot.

    PubMed

    Möller, H-J

    2005-08-01

    Relapse is one of the key factors in the long-term outcome of schizophrenia. The consequences of relapse are diverse and often unpredictable, and the time to recovery and degree of recovery worsen with each successive relapse. There is now overwhelming evidence that advances in antipsychotic drug treatment have led to significant reductions in the rate of relapse. This review charts the developments that have taken place in antipsychotic therapy from the introduction of depot formulations, through atypical agents, to the development of the first long-acting atypical antipsychotic. Depot formulations of conventional antipsychotics were developed in the 1960s and led to fewer relapses and episodes of hospitalization, compared with oral equivalents. Meta-analysis has confirmed that patients receiving depot antipsychotics experience significantly greater global improvement than those receiving the respective oral agents. Conventional antipsychotics are, however, associated with a range of potentially serious adverse events. The atypical antipsychotics were introduced in the 1990s and have significant advantages over conventional agents with regard to positive and negative symptoms. There is also evidence that atypical agents can reduce the risk of relapse. Importantly, atypical antipsychotics have an improved safety profile compared with older agents, particularly with regard to extrapyramidal symptoms. One disadvantage of atypical agents has been that they are only available in an oral form. The recent development of a long-acting injectable formulation of risperidone means that a new treatment option is available to physicians.

  1. A Genetically Engineered Thermally Responsive Sustained Release Curcumin Depot to Treat Neuroinflammation

    PubMed Central

    Sinclair, S. Michael; Bhattacharyya, Jayanta; McDaniel, Jonathan R.; Gooden, David M.; Gopalaswamy, Ramesh; Chilkoti, Ashutosh; Setton, Lori A.

    2014-01-01

    Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration of TNF antagonists for radiculopathy in the clinic has shown mixed results, and there is growing interest in the local delivery of anti-inflammatory drugs to treat this pathology as well as similar inflammatory events of peripheral nerve injury. Curcumin, a known antagonist of TNFα in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation. ELPs are biopolymers capable of thermally-triggered in situ depot formation that have been successfully employed as drug carriers and biomaterials in several applications. ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactivity against TNFα-induced cytotoxicity and monocyte activation with IC50 only two-fold higher than curcumin. When injected proximal to the sciatic nerve in mice via intramuscular (i.m.) injection, ELP-curcumin conjugates underwent a thermally triggered soluble-insoluble phase transition, leading to in situ formation of a depot that released curcumin over 4 days post-injection and decreased plasma AUC 7-fold. PMID:23830979

  2. Pharmacokinetic Studies of Sustained-Release Depot of Dexamethasone in Beagle Dogs

    PubMed Central

    Desai, Ankita; Driscoll, Arthur

    2016-01-01

    Abstract Purpose: To examine the pharmacokinetic characteristics of sustained-release dexamethasone depots in two separate canine studies. Methods: Dexamethasone depots loaded with a clinically representative (0.4 mg) dose (DEXTENZA™; Ocular Therapeutix) or an elevated (0.7 mg) dose were inserted into the canaliculi of beagle eyes (n = 37 and n = 34, respectively). Tear fluid was collected for pharmacokinetic analysis of dexamethasone in both studies at predetermined time points. Explanted 0.4 mg depots were collected weekly to measure remaining drug level. Clinical observations and ophthalmic examinations were performed in both studies at each visit. Results: The 0.4 mg depots released a median 308 μg by day 15 and tapered to complete drug release by day 28. Median dexamethasone tear fluid concentrations in the 0.4 mg study group decreased from 2,805 ng/mL at day 7 to 0 ng/mL on day 28. Median dexamethasone tear fluid concentrations in the 0.7 mg study group decreased from 4,370 ng/mL at 6 h post insertion to 830 ng/mL on day 35. Mean ± standard deviation intraocular pressures in the 0.4 and 0.7 mg study groups were 20.7 ± 2.8 and 19.0 ± 4.1 mmHg at baseline, respectively, and demonstrated no meaningful change (20.5 ± 3.0 and 20.6 ± 2.9 mmHg, respectively) over the studies' durations. No ocular toxicities were attributed to the dexamethasone depot. Conclusion: Sustained-release dexamethasone produced no identifiable ocular toxicity in this animal model, and pharmacokinetics demonstrated a sustained and tapered drug release over 28 days at a 0.4 mg dose and exceeded 35 days at a 0.7 mg dose. PMID:27483129

  3. Employment-Based Reinforcement of Adherence to Depot Naltrexone in Unemployed Opioid-Dependent Adults: A Randomized Controlled Trial

    PubMed Central

    Everly, Jeffrey J.; DeFulio, Anthony; Koffarnus, Mikhail N.; Leoutsakos, Jeannie-Marie S.; Donlin, Wendy D.; Aklin, Will M.; Umbricht, Annie; Fingerhood, Michael; Bigelow, George E.; Silverman, Kenneth

    2011-01-01

    Aims Naltrexone can be used to treat opioid dependence, but patients refuse to take it. Extended-release depot formulations may improve adherence, but long-term adherence rates to depot naltrexone are not known. This study determined long-term rates of adherence to depot naltrexone and whether employment-based reinforcement can improve adherence. Design Participants who were inducted onto oral naltrexone were randomly assigned to Contingency (n=18) or Prescription (n=17) groups. Participants were offered six depot naltrexone injections and invited to work at the therapeutic workplace weekdays for 26 weeks where they earned stipends for participating in job skills training. Contingency participants were required to accept naltrexone injections to maintain workplace access and to maintain maximum pay. Prescription participants could work independent of whether they accepted injections. Setting The therapeutic workplace, a model employment-based intervention for drug addiction and unemployment. Participants Opioid-dependent unemployed adults. Measurements Depot naltrexone injections accepted and opiate-negative urine samples. Findings Contingency participants accepted significantly more naltrexone injections than Prescription participants (81% versus 42%), and were more likely to accept all injections (66% versus 35%). At monthly assessments (with missing urine samples imputed as positive), the groups provided similar percentages of samples negative for opiates (74% versus 62%) and for cocaine (56% versus 54%). Opiate positive samples were more likely when samples were also positive for cocaine. Conclusions Employment-based reinforcement can maintain adherence to depot naltrexone. Future research should determine whether persistent cocaine use compromises naltrexone's effect on opiate use. Workplaces may be useful for promoting sustained adherence to depot naltrexone. PMID:21320227

  4. Characterization of stromal vascular fraction and adipose stem cells from subcutaneous, preperitoneal and visceral morbidly obese human adipose tissue depots

    PubMed Central

    Silva, Karina Ribeiro; Côrtes, Isis; Liechocki, Sally; Carneiro, João Regis Ivar; Souza, Antônio Augusto Peixoto; Borojevic, Radovan; Maya-Monteiro, Clarissa Menezes

    2017-01-01

    Background/Objectives The pathological condition of obesity is accompanied by a dysfunctional adipose tissue. We postulate that subcutaneous, preperitoneal and visceral obese abdominal white adipose tissue depots could have stromal vascular fractions (SVF) with distinct composition and adipose stem cells (ASC) that would differentially account for the pathogenesis of obesity. Methods In order to evaluate the distribution of SVF subpopulations, samples of subcutaneous, preperitoneal and visceral adipose tissues from morbidly obese women (n = 12, BMI: 46.2±5.1 kg/m2) were collected during bariatric surgery, enzymatically digested and analyzed by flow cytometry (n = 12). ASC from all depots were evaluated for morphology, surface expression, ability to accumulate lipid after induction and cytokine secretion (n = 3). Results A high content of preadipocytes was found in the SVF of subcutaneous depot (p = 0.0178). ASC from the three depots had similar fibroblastoid morphology with a homogeneous expression of CD34, CD146, CD105, CD73 and CD90. ASC from the visceral depot secreted the highest levels of IL-6, MCP-1 and G-CSF (p = 0.0278). Interestingly, preperitoneal ASC under lipid accumulation stimulus showed the lowest levels of all the secreted cytokines, except for adiponectin that was enhanced (p = 0.0278). Conclusions ASC from preperitoneal adipose tissue revealed the less pro-inflammatory properties, although it is an internal adipose depot. Conversely, ASC from visceral adipose tissue are the most pro-inflammatory. Therefore, ASC from subcutaneous, visceral and preperitoneal adipose depots could differentially contribute to the chronic inflammatory scenario of obesity. PMID:28323901

  5. Stokes-Leibenson problem for Hele-Shaw flow: a critical set in the space of contours

    NASA Astrophysics Data System (ADS)

    Demidov, A. S.; Lohéac, J.-P.; Runge, V.

    2016-01-01

    The Stokes-Leibenson problem for Hele-Shaw flow is reformulated as a Cauchy problem of a nonlinear integro-differential equation with respect to functions a and b, linked by the Hilbert transform. The function a expresses the evolution of the coefficient longitudinal strain of the free boundary and b is the evolution of the tangent tilt of this contour. These functions directly reflect changes of geometric characteristics of the free boundary of higher order than the evolution of the contour point obtained by the classical Galin-Kochina equation. That is why we managed to uncover the reason of the absence of solutions in the sink-case if the initial contour is not analytic at at least one point, to prove existence and uniqueness theorems, and also to reveal a certain critical set in the space of contours. This set contains one attractive point in the source-case corresponding to a circular contour centered at the source-point. The main object of this work is the analysis of the discrete model of the problem. This model, called quasi-contour, is formulated in terms of functions corresponding to a and b of our integro-differential equation. This quasi-contour model provides numerical experiments which confirm the theoretical properties mentioned above, especially the existence of a critical subset of co-dimension 1 in space of quasi-contours. This subset contains one attractive point in the source-case corresponding to a regular quasi-contour centered at the source-point. The main contribution of our quasi-contour model concerns the sink-case: numerical experiments show that the above subset is attractive. Furthermore, this discrete model allows to extend previous results obtained by using complex analysis. We also provide numerical experiments linked to fingering effects.

  6. Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: Implications for HIV susceptibility

    PubMed Central

    Smith-McCune, Karen K.; Hilton, Joan F.; Shanmugasundaram, Uma; Critchfield, J. William; Greenblatt, Ruth M.; Seidman, Dominika; Averbach, Sarah; Giudice, Linda; Shacklett, Barbara L.

    2016-01-01

    Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several reproductive tract compartments relevant to HIV-1 susceptibility in upper reproductive tract samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared to samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T-cells. Unlike previous reports with samples from the vagina, we did not observe increased expression of the HIV co-receptor CCR5 on CD4+ T-cells in the endocervix or endometrium. Our results indicate important differences in anatomic compartments regarding mechanisms by which depot-medroxyprogesterone acetate could be associated with increased risk of HIV acquisition, including increased recruitment of macrophages to the endometrium, decreased levels of pro-inflammatory cytokines in the endocervix possibly leading to enhanced susceptibility to viral infection, and activation of endometrial T-cells. PMID:28051087

  7. Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice.

    PubMed

    Sackmann-Sala, Lucila; Berryman, Darlene E; Lubbers, Ellen R; Zhang, Han; Vesel, Clare B; Troike, Katie M; Gosney, Elahu S; List, Edward O; Kopchick, John J

    2014-01-01

    Growth hormone receptor-null (GHR(-/-)) mice are dwarf, insulin sensitive, and long-lived in spite of increased adiposity. However, their adiposity is not uniform, with select white adipose tissue (WAT) depots enlarged. To study WAT depot-specific effects on insulin sensitivity and life span, we analyzed individual WAT depots of 12- and 24-month-old GHR(-) (/-) and wild-type (WT) mice, as well as their plasma levels of selected hormones. Adipocyte sizes and plasma insulin, leptin, and adiponectin levels decreased with age in both GHR(-) (/-) and WT mice. Two-dimensional gel electrophoresis proteomes of WAT depots were similar among groups, but several proteins involved in endocytosis and/or cytoskeletal organization (Ehd2, S100A10, actin), anticoagulation (S100A10, annexin A5), and age-related conditions (alpha2-macroglobulin, apolipoprotein A-I, transthyretin) showed significant differences between genotypes. Because Ehd2 may regulate endocytosis of Glut4, we measured Glut4 levels in the WAT depots of GHR(-) (/-) and WT mice. Inguinal WAT of 12-month-old GHR(-) (/-) mice displayed lower levels of Glut4 than WT. Overall, the protein changes detected in this study offer new insights into possible mechanisms contributing to enhanced insulin sensitivity and extended life span in GHR(-) (/-) mice.

  8. Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: implications for HIV susceptibility.

    PubMed

    Smith-McCune, K K; Hilton, J F; Shanmugasundaram, U; Critchfield, J W; Greenblatt, R M; Seidman, D; Averbach, S; Giudice, L C; Shacklett, B L

    2017-09-01

    Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several upper reproductive tract compartments relevant to HIV-1 susceptibility in repetitive samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells. Unlike previous reports with samples from the vagina, we did not observe increased expression of the HIV co-receptor CCR5 on CD4+ T cells in the endocervix or endometrium. Our results indicate important differences in anatomic compartments regarding mechanisms by which depot-medroxyprogesterone acetate could be associated with increased risk of HIV acquisition, including increased recruitment of macrophages to the endometrium, decreased levels of pro-inflammatory cytokines in the endocervix possibly leading to enhanced susceptibility to viral infection, and activation of endometrial T cells.

  9. On a new species of Neoechinorhynchus Hamann, 1892 (Acanthocephala: Neoechinorhynchoidea Southwell et Macfie, 1925) from Indian threadfin fish, Leptomelanosoma indicum Shaw, 1804 from Visakhapatnam coast, Andhra Pradesh, India.

    PubMed

    Gudivada, Mani; Chikkam, Vijayalakshmi; Vankara, Anu Prasanna

    2010-10-01

    A new acanthocephalan of the genus Neoechinorhynchus Hamman, 1892 (Acanthocephala: Neoaechinorhynchoidea Southwell et Macfie, 1925) parasitic on threadfin fish, Leptomelanosoma indicum Shaw, 1804 from Visakhapatnam coast, Andhra Pradesh, India is described. Neoechinorhynchus indicus sp. nov is characterized by an enormous body size, structural characteristics of the hooks on proboscis, presence of body annulations, two guard cells, unequal lemnisci, sub-terminal genital pore and the host. N. indicus sp.nov is included in the genus by the presence of three rows of six hooks each on the proboscis and a single layered proboscis receptacle.

  10. Analytic theory of the selection mechanism in the Saffman-Taylor problem. [concerning shape of fingers in Hele-Shaw cell

    NASA Technical Reports Server (NTRS)

    Hong, D. C.; Langer, J. S.

    1986-01-01

    An analytic approach to the problem of predicting the widths of fingers in a Hele-Shaw cell is presented. The analysis is based on the WKB technique developed recently for dealing with the effects of surface tension in the problem of dendritic solidification. It is found that the relation between the dimensionless width lambda and the dimensionless group of parameters containing the surface tension, nu, has the form lambda - 1/2 = nu exp 2/3 in the limit of small nu.

  11. Analytic theory for the determination of velocity and stability of bubbles in a Hele-Shaw cell. I - Velocity selection. II - Stability

    NASA Technical Reports Server (NTRS)

    Tanveer, S.

    1989-01-01

    An asymptotic theory is presented for the determination of velocity and linear stability of a steady symmetric bubble in a Hele-Shaw cell for small surface tension. First the bubble velocity relative to the fluid velocity at infinity is determined for small surface tension by means of a transcendentally small correction to the asymptotic series solution. In addition, a linear stability analysis shows that only the solution branch corresponding to the largest possible bubble velocity for given surface tension is stable, while all the others are unstable.

  12. Analytic theory for the determination of velocity and stability of bubbles in a Hele-Shaw cell. I - Velocity selection. II - Stability

    NASA Technical Reports Server (NTRS)

    Tanveer, S.

    1989-01-01

    An asymptotic theory is presented for the determination of velocity and linear stability of a steady symmetric bubble in a Hele-Shaw cell for small surface tension. First the bubble velocity relative to the fluid velocity at infinity is determined for small surface tension by means of a transcendentally small correction to the asymptotic series solution. In addition, a linear stability analysis shows that only the solution branch corresponding to the largest possible bubble velocity for given surface tension is stable, while all the others are unstable.

  13. Analytic theory of the selection mechanism in the Saffman-Taylor problem. [concerning shape of fingers in Hele-Shaw cell

    NASA Technical Reports Server (NTRS)

    Hong, D. C.; Langer, J. S.

    1986-01-01

    An analytic approach to the problem of predicting the widths of fingers in a Hele-Shaw cell is presented. The analysis is based on the WKB technique developed recently for dealing with the effects of surface tension in the problem of dendritic solidification. It is found that the relation between the dimensionless width lambda and the dimensionless group of parameters containing the surface tension, nu, has the form lambda - 1/2 = nu exp 2/3 in the limit of small nu.

  14. Assessment of concentrations of trace elements in ground water and soil at the Small-Arms Firing Range, Shaw Air Force Base, South Carolina

    USGS Publications Warehouse

    Landmeyer, J.E.

    1994-01-01

    Ground-water samples were collected from four shallow water-table aquifer observation wells beneath the Small-Arms Firing Range study area at Shaw Air Force Base. Water-chemistry analyses indicated that total lead concentrations in shallow ground water beneath the study area do not exceed the U.S. Environmental Protection Agency maximum contaminant level established for lead in drinking water (0.05 milligrams per liter). All other trace element total concentrations in ground water beneath the study area were at or below the detection limit of the analytical methodology.

  15. Synthetic Fuel

    SciTech Connect

    Idaho National Laboratory - Steve Herring, Jim O'Brien, Carl Stoots

    2008-03-26

    Two global energy priorities today are finding environmentally friendly alternatives to fossil fuels, and reducing greenhouse gass Two global energy priorities today are finding environmentally friendly alternatives to fossil fuels, and reducing greenhous

  16. Synthetic Fuel

    ScienceCinema

    Idaho National Laboratory - Steve Herring, Jim O'Brien, Carl Stoots

    2016-07-12

    Two global energy priorities today are finding environmentally friendly alternatives to fossil fuels, and reducing greenhouse gass Two global energy priorities today are finding environmentally friendly alternatives to fossil fuels, and reducing greenhous

  17. Fuel cells

    NASA Astrophysics Data System (ADS)

    1984-12-01

    The US Department of Energy (DOE), Office of Fossil Energy, has supported and managed a fuel cell research and development (R and D) program since 1976. Responsibility for implementing DOE's fuel cell program, which includes activities related to both fuel cells and fuel cell systems, has been assigned to the Morgantown Energy Technology Center (METC) in Morgantown, West Virginia. The total United States effort of the private and public sectors in developing fuel cell technology is referred to as the National Fuel Cell Program (NFCP). The goal of the NFCP is to develop fuel cell power plants for base-load and dispersed electric utility systems, industrial cogeneration, and on-site applications. To achieve this goal, the fuel cell developers, electric and gas utilities, research institutes, and Government agencies are working together. Four organized groups are coordinating the diversified activities of the NFCP. The status of the overall program is reviewed in detail.

  18. Future Fuels

    DTIC Science & Technology

    2005-10-04

    tactical ground mobility and increasing operational reach • Identify, review, and assess – Technologies for reducing fuel consumption, including...T I O N S A C T I O N S TOR Focus - Tactical ground mobility - Operational reach - Not A/C, Ships, or troops Hybrid Electric Vehicle Fuel Management...Fuel Management During Combat Operations Energy Fundamentals • Energy Density • Tactical Mobility • Petroleum Use • Fuel Usage (TWV) • TWV OP TEMPO TOR

  19. Alternative Fuels

    DTIC Science & Technology

    2009-06-11

    JP-8 BACK-UP SLIDES Unclassified 19 What Are Biofuels ? Cellulose “first generation”“second generation” C18:0 C16:1 Triglycerides (fats, oils ...equipment when supplying jet fuel not practicable or cost effective Unclassified 5 erna ve ue s ocus Petroleum Crude Oil (declining discovery / production...on Jet A/A-1 Approved fuels, DXXXX Unclassified 6 JP-8/5 (Commercial Jet Fuel, ASTM Spec) DARPA Alternative Jet Fuels • Agricultural crop oils

  20. Fossil Fuels.

    ERIC Educational Resources Information Center

    Crank, Ron

    This instructional unit is one of 10 developed by students on various energy-related areas that deals specifically with fossil fuels. Some topics covered are historic facts, development of fuels, history of oil production, current and future trends of the oil industry, refining fossil fuels, and environmental problems. Material in each unit may…

  1. Fossil Fuels.

    ERIC Educational Resources Information Center

    Crank, Ron

    This instructional unit is one of 10 developed by students on various energy-related areas that deals specifically with fossil fuels. Some topics covered are historic facts, development of fuels, history of oil production, current and future trends of the oil industry, refining fossil fuels, and environmental problems. Material in each unit may…

  2. Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue.

    PubMed

    Lecoutre, Simon; Deracinois, Barbara; Laborie, Christine; Eberlé, Delphine; Guinez, Céline; Panchenko, Polina E; Lesage, Jean; Vieau, Didier; Junien, Claudine; Gabory, Anne; Breton, Christophe

    2016-07-01

    According to the Developmental Origin of Health and Disease (DOHaD) concept, alterations of nutrient supply in the fetus or neonate result in long-term programming of individual body weight (BW) setpoint. In particular, maternal obesity, excessive nutrition, and accelerated growth in neonates have been shown to sensitize offspring to obesity. The white adipose tissue may represent a prime target of metabolic programming induced by maternal obesity. In order to unravel the underlying mechanisms, we have developed a rat model of maternal obesity using a high-fat (HF) diet (containing 60% lipids) before and during gestation and lactation. At birth, newborns from obese dams (called HF) were normotrophs. However, HF neonates exhibited a rapid weight gain during lactation, a key period of adipose tissue development in rodents. In males, increased BW at weaning (+30%) persists until 3months of age. Nine-month-old HF male offspring was normoglycemic but showed mild glucose intolerance, hyperinsulinemia, and hypercorticosteronemia. Despite no difference in BW and energy intake, HF adult male offspring was predisposed to fat accumulation showing increased visceral (gonadal and perirenal) depots weights and hyperleptinemia. However, only perirenal adipose tissue depot exhibited marked adipocyte hypertrophy and hyperplasia with elevated lipogenic (i.e. sterol-regulated element binding protein 1 (Srebp1), fatty acid synthase (Fas), and leptin) and diminished adipogenic (i.e. peroxisome proliferator-activated receptor gamma (Pparγ), 11β-hydroxysteroid dehydrogenase type 1 (11β-Hds1)) mRNA levels. By contrast, very few metabolic variations were observed in HF female offspring. Thus, maternal obesity and accelerated growth during lactation program offspring for higher adiposity via transcriptional alterations of visceral adipose tissue in a depot- and sex-specific manner.

  3. Eradicating hepatitis C virus ameliorates insulin resistance without change in adipose depots.

    PubMed

    Milner, K-L; Jenkins, A B; Trenell, M; Tid-Ang, J; Samocha-Bonet, D; Weltman, M; Xu, A; George, J; Chisholm, D J

    2014-05-01

    Chronic hepatitis C (CHC) is associated with lipid-related changes and insulin resistance; the latter predicts response to antiviral therapy, liver disease progression and the risk of diabetes. We sought to determine whether insulin sensitivity improves following CHC viral eradication after antiviral therapy and whether this is accompanied by changes in fat depots or adipokine levels. We compared 8 normoglycaemic men with CHC (genotype 1 or 3) before and at least 6 months post viral eradication and 15 hepatitis C antibody negative controls using an intravenous glucose tolerance test and two-step hyperinsulinaemic-euglycaemic clamp with [6,6-(2) H2 ] glucose to assess peripheral and hepatic insulin sensitivity. Magnetic resonance imaging and spectroscopy quantified abdominal fat compartments, liver and intramyocellular lipid. Peripheral insulin sensitivity improved (glucose infusion rate during high-dose insulin increased from 10.1 ± 1.6 to 12 ± 2.1 mg/kg/min/, P = 0.025), with no change in hepatic insulin response following successful viral eradication, without any accompanying change in muscle, liver or abdominal fat depots. There was corresponding improvement in incremental glycaemic response to intravenous glucose (pretreatment: 62.1 ± 8.3 vs post-treatment: 56.1 ± 8.5 mm, P = 0.008). Insulin sensitivity after viral clearance was comparable to matched controls without CHC. Post therapy, liver enzyme levels decreased but, interestingly, levels of glucagon, fatty acid-binding protein and lipocalin-2 remained elevated. Eradication of the hepatitis C virus improves insulin sensitivity without alteration in fat depots, adipokine or glucagon levels, consistent with a direct link of the virus with insulin resistance. © 2013 John Wiley & Sons Ltd.

  4. Community Environmental Response Facilitation Act (CERFA) report, Sacramento Army Depot, Sacramento, California. Final report

    SciTech Connect

    Not Available

    1994-04-01

    This report presents the results of the Community Environmental Response Facilitation Act (CERFA) investigation conducted at the Sacramento Army Depot (SAAD), a U.S. Government property selected for closure by the Base Realignment and Closure Commission. The primary objective of this investigation, as required under CERFA is for federal agencies to expeditiously identify real property offering the greatest opportunity for immediate reuse and redevelopment. Satisfying this objective requires the identification of real property where no CERCLE-regulated hazardous substances or petroleum or their derivatives were stored for one year or more, known to have been released, or disposed of.

  5. A-Train Data Depot: Integrating and Exploring Data Along the A-Train Tracks

    NASA Technical Reports Server (NTRS)

    Leptoukh, G.; Kempler, S.; Smith, P.; Savtchenko, A.; Kummerer, R.; Gopalan, A.; Farley, J.; Chen, A.

    2007-01-01

    The immense potential for new science findings as a result of inter-instrument data analysis has led to the development of a new data portal at GSFC: the A-train Data Depot. The power and utility of this new service to the general public is amplified immensely when the archived data are used in conjunction with online data analysis services like Giovanni. This presentation details some of the challenges of data usage from multiple distinct missions and how the tool sets we have developed can help to overcome these challenges, considerably cut down on analysis overhead and promote science exploration in an otherwise very challenging arena.

  6. [Computer-assisted management of depots for blood products in health establishments].

    PubMed

    Carré, J

    2008-11-01

    To manage the filing of blood components at the hospital of the city of Bayeux, the laboratory uses Cursus, a dedicated software for haemovigilance. Benefits for using this software at different steps of the blood bank management are: simplification, security and harmonization of practices during receipt and issurance of blood components, securing recordings with the use of bar codes for patient identification and blood components listing, implementation of a computerized tracking system for transfusion, traceability, limitation of written documents and availability of statistics on the management of the depot.

  7. Anaphylaxis Triggered by Benzyl Benzoate in a Preparation of Depot Testosterone Undecanoate

    PubMed Central

    Ong, Gregory S. Y.; Somerville, Colin P.; Jones, Timothy W.; Walsh, John P.

    2012-01-01

    We report the first case of an anaphylactic reaction to Reandron 1000 (depot testosterone undecanoate with a castor oil and benzyl benzoate vehicle). While considered to have a favourable safety profile, serious complications such as oil embolism and anaphylaxis can occur. In our patient, skin testing identified benzyl benzoate to be the trigger, with no reaction to castor oil or testosterone undecanoate components. As benzyl benzoate exists in multiple pharmaceuticals, foods, and cosmetics, individual components of pharmaceuticals should be tested when investigating drug allergies. Doctors should be alert to the potential for serious reactions to any of the components of Reandron 1000. PMID:22272209

  8. Review and Evaluation of Army Aviation Depot NDI (Nondestructive Inspection) and Reliability Centered Maintenance

    DTIC Science & Technology

    1988-08-31

    Visual, MT, and/or PT. CH-47 Fan Motor Visual only MT and/or PT; UT and ET 55-1520-210 for inspection of honey- UH- iH comb composite structures...CENrERED MAINTENANCE TO DEPOT MAINTENANCE WORK REQUIREMENTS FINAL DMWR REPORT DMIJR Number 55-1650-157 This Document Contains 9 Pages. Fan Motor NSN...impact design and ooeratoon-i oncepts; to identify tne gross -ogist-c resource requirements of alternative concepts; and to reate esign, operational

  9. Dot Enumeration Perceptual Organization Task (DEPOT): evidence for a short-term visual memory deficit in schizophrenia.

    PubMed

    Rabinowicz, E F; Opler, L A; Owen, D R; Knight, R A

    1996-08-01

    The Dot Enumeration Perceptual Organization Task (DEPOT) evaluates the validity of 2 specific competing cognitive models of early input dysfunction in schizophrenic individuals: a primary Stage 1, sensory store, perceptual organization deficit vs. a Stage 2, short-term visual memory (STVM) deficit. DEPOT was also designed to assess the hypothesis that schizophrenic individuals tend to perform poorly on all cognitive tasks. In DEPOT both number and form judgments are made about the same dot patterns. A response delay manipulation assesses the persistence and operation of STVM. The study included 41 psychotic inpatients (8 with acute and 16 with chronic schizophrenia and 7 with bipolar and 10 with nonbipolar affective disorder) and 38 controls (22 college students and 16 hospital personnel). Although the pattern of results was consistent with neither the Stage 1 deficit nor the general deficit hypotheses, a Stage 2, STVM deficit hypothesis could account parsimoniously for the data.

  10. Changes Are Needed to the Army Contract with Sikorsky to Use Existing DoD Inventory and Control Costs at the Corpus Christi Army Depot

    DTIC Science & Technology

    2011-11-03

    levels, monthly consumption data, and DLA standard unit prices for all DLA consumables . Enterprise Business System EBS is DLA’s primary...the business case analysis for BRAC CIT, consumable items that were part of a contractor logistics support contract, such as the CCAD/Sikorsky...Army Depot CIT Consumable Item Transfer DLA Defense Logistics Agency DOF Depot Overhaul Factor EBS

  11. 33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480...; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. (a) The areas. (1) The... in paragraph (a) of this section when the adjacent rifle or pistol ranges on U.S. Marine...

  12. 33 CFR 334.480 - Archers Creek, Ribbon Creek and Broad River, S.C.; U.S. Marine Corps Recruit Depot rifle and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Broad River, S.C.; U.S. Marine Corps Recruit Depot rifle and pistol ranges, Parris Island. 334.480..., S.C.; U.S. Marine Corps Recruit Depot rifle and pistol ranges, Parris Island. (a) During periods when the rifle and pistol ranges on Parris Island are in use, the following areas will be restricted to...

  13. Comparative in vitro release and clinical pharmacokinetics of leuprolide from Luphere 3M Depot, a 3-month release formulation of leuprolide acetate.

    PubMed

    Park, Sunghoon; Kim, Dong-Hwan; Kim, Yoon; Park, Jeong Hwa; Lee, MinSeok; Song, Im-Sook; Shim, Chang-Koo

    2017-03-01

    A 3-month depot formulation of leuprolide acetate (Luphere 3M Depot) with a mean microsphere diameter of 22.3 μm was prepared aseptically by spray-drying glacial acetic acid solution of the drug and polylactic acid, and lyophilization in a d-mannitol solution. The encapsulation efficiency and loading content of the drug in the Luphere 3M Depot were 94.7% and 9.92% (w/w), respectively. The in vitro release of leuprolide from the depot was substantially delayed and the release profile was similar to that of Lucrin Depot (Abbott Korea, Korea). The safety and pharmacokinetics of leuprolide were investigated over a period of 42 days in 20 prostate cancer patients following a subcutaneous injection of Luphere 3M or Lucrin Depot suspensions (leuprolide acetate dose of 11.25 mg) in a multi-center, randomized, single dose, parallel study. Both formulations were well tolerated by the patients and no serious adverse effects were observed during and after the study. No significant differences were observed in the maximum serum concentration (Cmax) and area under the curve (AUClast) of leuprolide between the two formulations. The results suggest comparable safety and efficacy profiles of Luphere 3M Depot and Lucrin Depot in clinical situations.

  14. 33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480...; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. (a) The areas. (1) The... River shall encompass all navigable waters of the United States, as defined at 33 CFR part 329, adjacent...

  15. 33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480...; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. (a) The areas. (1) The... River shall encompass all navigable waters of the United States, as defined at 33 CFR part 329, adjacent...

  16. Modeling leakage pathways in subsurface formations. Fluid drainage through multiple fractures in porous media: Insights from Hele Shaw cell experiments

    NASA Astrophysics Data System (ADS)

    Ray, Sujata

    2017-04-01

    Arresting the recent observed warming of the earth's climate is a challenge requiring the reduction of anthropogenic emissions of carbon dioxide. One option for reducing emissions into the atmosphere is to capture and sequester the released carbon dioxide in geological formations. However, potential geological storage first requires a risk assessment of carbon dioxide escaping to overlying layers and back to the atmosphere through leakage pathways in the formation. This, in turn, requires an understanding of fluid flow through the leakage pathways. In this study, the effect of leakage pathways on the flow of a gravity current was investigated, using an analogue system, a Hele-Shaw cell. Fluid was introduced through the top edge of the cell and flowed out through one or more holes in its impermeable base. The height of the accumulated fluid above the base of the cell at various points along its length and the outflow rate of fluid through the holes was measured. This measurement was conducted with varying conditions of the location, number and strength of source as well as the location and number of holes. At steady state, the fluid motion was in accordance with Darcy's law for horizontal flow in a long thin current. In another set of experiments, in which inflow was stopped and the fluid was allowed to drain out of a single open hole, the outflow rate was in accordance with Darcy's law for one-dimensional flow in the vertical direction until the fluid height above the hole fell below a certain limit. This threshold height was found to be 1.3 cm, which was similar in magnitude to the length of the hole. A time series of photographs tracked the flow of colored dye. The photographs demonstrated that at steady state the fluid traveled for some distance beyond the hole before draining through it. This implies that contaminants may be transported in a formation even beyond an outlet before finally draining out through it. The photographs also documented the shape of the

  17. Alternative fuels

    NASA Technical Reports Server (NTRS)

    Grobman, J. S.; Butze, H. F.; Friedman, R.; Antoine, A. C.; Reynolds, T. W.

    1977-01-01

    Potential problems related to the use of alternative aviation turbine fuels are discussed and both ongoing and required research into these fuels is described. This discussion is limited to aviation turbine fuels composed of liquid hydrocarbons. The advantages and disadvantages of the various solutions to the problems are summarized. The first solution is to continue to develop the necessary technology at the refinery to produce specification jet fuels regardless of the crude source. The second solution is to minimize energy consumption at the refinery and keep fuel costs down by relaxing specifications.

  18. Fuel compositions

    SciTech Connect

    Mekonen, K.

    1989-10-31

    This patent describes a hydrosol fuel. It comprises: from about 67% to 94% by weight of a hydrocarbon combustible fuel selected from the group consisting of the gasolines, diesel fuels and heavy fuel oils, from 5 to 25% by weight of water, at least one surfactant operable to create a hydrosol with the fuel and water present in the range of 0.1 up to about 3.4% by weight of an additive selected from the group consisting of alpha (mono) olefins and alkyl benzenes, each of the former having 7 to 15 recurring C{sub 2} monomers therein.

  19. Cost analysis of leuprorelin acetate in Japanese prostate cancer patients: comparison between 6-month and 3-month depot formulations.

    PubMed

    Goto, Rei; Uda, Akihito; Hiroi, Shinzo; Iwasaki, Kosuke; Takashima, Kenta; Oya, Mototsugu

    2017-08-16

    This study aimed to evaluate the economic value for leuprorelin acetate 6-month depot compared with leuprorelin acetate 3-month depot from a societal perspective in Japanese prostate cancer patients. The cost analysis estimated the reduction in direct and indirect costs as well as intangible costs saved by having one less injection. Claims data were used for the analyses of direct and indirect costs reduction. A discrete choice experiment based on a web-based survey estimated the monetary value of the intangible costs for one injection. Another web-based survey of prostate cancer patients, who had received treatment with leuprorelin acetate injections, was carried out to calibrate the results of the discrete choice experiment. Reductions in medical costs and loss of productivity for having one less injection in prostate cancer patients receiving leuprorelin acetate were JPY 5,670 and JPY 1,723, respectively. Intangible costs saved by using a 6-month depot formulation instead of a 3-month depot formulation for the injection of leuprorelin acetate were estimated to be JPY 19,872, including the values for a reduction in pain (JPY 3,131), injection site reactions (JPY 11,545), waiting time (JPY 9,479), and subtracting the value of medical consultation (JPY 4,283). The total cost reduction for having one less injection was JPY 27,265. The respondents from the internet panel provided by a survey company are not necessarily a representative population of Japanese society. Leuprorelin acetate 6-month depot has an advantage in monetary value in the reduction in medical costs, loss of productivity, and intangible costs for having one less injection in prostate cancer patients compared with leuprorelin acetate 3-month depot. In the costs for treating with leuprorelin acetate, the percentage of intangible costs might not be negligible. The intangible costs will probably be actively evaluated to proceed to patient-centered healthcare in society.

  20. The effect of a crosslinking chemical reaction on pattern formation in viscous fingering of miscible fluids in a Hele-Shaw cell

    NASA Astrophysics Data System (ADS)

    Bunton, Patrick H.; Tullier, Michael P.; Meiburg, Eckart; Pojman, John A.

    2017-10-01

    Viscous fingering can occur in fluid motion whenever a high mobility fluid displaces a low mobility fluid in a Darcy type flow. When the mobility difference is primarily attributable to viscosity (e.g., flow between the two horizontal plates of a Hele-Shaw cell), viscous fingering (VF) occurs, which is sometimes termed the Saffman-Taylor instability. Alternatively, in the presence of differences in density in a gravity field, buoyancy-driven convection can occur. These instabilities have been studied for decades, in part because of their many applications in pollutant dispersal, ocean currents, enhanced petroleum recovery, and so on. More recent interest has emerged regarding the effects of chemical reactions on fingering instabilities. As chemical reactions change the key flow parameters (densities, viscosities, and concentrations), they may have either a destabilizing or stabilizing effect on the flow. Hence, new flow patterns can emerge; moreover, one can then hope to gain some control over flow instabilities through reaction rates, flow rates, and reaction products. We report effects of chemical reactions on VF in a Hele-Shaw cell for a reactive step-growth cross-linking polymerization system. The cross-linked reaction product results in a non-monotonic viscosity profile at the interface, which affects flow stability. Furthermore, three-dimensional internal flows influence the long-term pattern that results.

  1. Tenofovir disoproxil fumarate intravaginal ring protects high-dose depot medroxyprogesterone acetate-treated macaques from multiple SHIV exposures.

    PubMed

    Smith, James M; Srinivasan, Priya; Teller, Ryan S; Lo, Yungtai; Dinh, Chuong T; Kiser, Patrick F; Herold, Betsy C

    2015-01-01

    Preclinical HIV prevention models use either a single high-dose viral challenge in depot medroxyprogesterone acetate-treated macaques or repeated viral challenges in cycling macaques. We tested the efficacy of an intravaginal tenofovir disoproxil fumarate (TDF) ring in a model combining repeated 30-mg injections of depot medroxyprogesterone acetate every 6 weeks with vaginal viral challenges weekly for 12 weeks. Twelve macaques were randomized to TDF or placebo rings. All placebo macaques became infected after a median of 2 exposures, whereas only 1 TDF macaque became infected at the eighth exposure (P = 0.0012). The TDF ring provides durable protection in a stringent challenge model.

  2. Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots

    PubMed Central

    Chusyd, Daniella E.; Wang, Donghai; Huffman, Derek M.; Nagy, Tim R.

    2016-01-01

    The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat. PMID:27148535

  3. Depot-specific regulation of autotaxin with obesity in human adipose tissue.

    PubMed

    Rancoule, Chloé; Dusaulcy, Rodolphe; Tréguer, Karine; Grès, Sandra; Guigné, Charlotte; Quilliot, Didier; Valet, Philippe; Saulnier-Blache, Jean Sébastien

    2012-12-01

    Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly produced by adipocytes and exerts a negative action on adipose tissue expansion. In both mice and humans, ATX expression increases with obesity in association with insulin resistance. In the present study, fat depot-specific regulation of ATX was explored in human. ATX mRNA expression was quantified in visceral and subcutaneous adipose tissue in obese (BMI > 40 kg/m(2); n = 27) and non-obese patients (BMI < 25 kg/m(2); n = 10). Whatever the weight status of the patients is, ATX expression was always higher (1.3- to 6-fold) in subcutaneous than in visceral fat. Nevertheless, visceral fat ATX was significantly higher (42 %) in obese than in non-obese patients, whereas subcutaneous fat ATX remained unchanged. In obese patients, visceral fat ATX expression was positively correlated with diastolic arterial blood pressure (r = 0.67; P = 0.001). This correlation was not observed with subcutaneous fat ATX. Visceral fat ATX was mainly correlated with leptin (r = 0.60; P = 0.001), inducible nitric oxide synthase (r = 0.58; P = 0,007), and apelin receptor (r = 0.50; P = 0.007). These correlations were not observed with subcutaneous fat ATX. These results reveal that obesity-associated upregulation of human adipose tissue ATX is specific to the visceral fat depot.

  4. Oral and depot progestin therapy for endometriosis: towards a personalized medicine.

    PubMed

    Buggio, Laura; Somigliana, Edgardo; Barbara, Giussy; Frattaruolo, Maria Pina; Vercellini, Paolo

    2017-09-24

    Endometriosis is an estrogen-dependent chronic inflammatory disorder that requires a life-long management plan. Long-term adherence to treatment is pivotal to ensure an effective clinical management. In this optic, one of the cornerstone of endometriosis medical treatment is represented by progestins. Areas covered: This narrative review examines the clinical efficacy, safety and tolerability of oral and depot progestins used in the treatment of endometriosis. The material included in the current manuscript was obtained with a MEDLINE search through PubMed from inception until February 2017. Expert opinion: Progestins are effective in controlling pain symptoms in the majority of women with endometriosis, and their effect seems not inferior to that achieved with other compounds used to treat the disease, such as gonadotropin-releasing hormone agonist. Available progestins include a broad range of both oral and depot compounds, and represent, in most cases, an inexpensive treatment option. In addition, progestins do not increase significantly thrombotic risk and could be adopted in those women with metabolic or cardiovascular contraindication to estrogen-progestins. The choice between the different available compounds should be tailored for every woman with preference to the most cost-effective treatment, depending on the most complained symptom and disease location.

  5. A two-stage approach to the depot shunting driver assignment problem with workload balance considerations

    PubMed Central

    Gronalt, Manfred; Sun, Yan

    2017-01-01

    Due to its environmentally sustainable and energy-saving characteristics, railway transportation nowadays plays a fundamental role in delivering passengers and goods. Emerged in the area of transportation planning, the crew (workforce) sizing problem and the crew scheduling problem have been attached great importance by the railway industry and the scientific community. In this paper, we aim to solve the two problems by proposing a novel two-stage optimization approach in the context of the electric multiple units (EMU) depot shunting driver assignment problem. Given a predefined depot shunting schedule, the first stage of the approach focuses on determining an optimal size of shunting drivers. While the second stage is formulated as a bi-objective optimization model, in which we comprehensively consider the objectives of minimizing the total walking distance and maximizing the workload balance. Then we combine the normalized normal constraint method with a modified Pareto filter algorithm to obtain Pareto solutions for the bi-objective optimization problem. Furthermore, we conduct a series of numerical experiments to demonstrate the proposed approach. Based on the computational results, the regression analysis yield a driver size predictor and the sensitivity analysis give some interesting insights that are useful for decision makers. PMID:28704489

  6. SeqDepot: streamlined database of biological sequences and precomputed features.

    PubMed

    Ulrich, Luke E; Zhulin, Igor B

    2014-01-15

    Assembling and/or producing integrated knowledge of sequence features continues to be an onerous and redundant task despite a large number of existing resources. We have developed SeqDepot-a novel database that focuses solely on two primary goals: (i) assimilating known primary sequences with predicted feature data and (ii) providing the most simple and straightforward means to procure and readily use this information. Access to >28.5 million sequences and 300 million features is provided through a well-documented and flexible RESTful interface that supports fetching specific data subsets, bulk queries, visualization and searching by MD5 digests or external database identifiers. We have also developed an HTML5/JavaScript web application exemplifying how to interact with SeqDepot and Perl/Python scripts for use with local processing pipelines. Freely available on the web at http://seqdepot.net/. RESTaccess via http://seqdepot.net/api/v1. Database files and scripts maybe downloaded from http://seqdepot.net/download.

  7. Unusual fatty acids in the depot fat of the Canadian beaver (Castor canadensis).

    PubMed

    Käkelä, R; Hyvärinen, H; Vainiotalo, P

    1996-03-01

    Unusual fatty acids in the adipose tissue of the Canadian beaver were analysed by argentation thin-layer chromatography, gas-liquid chromatography and gas chromatography-mass spectrometry of several adducts and spectroscopic measurements. The total proportion of trans-octadecenoic fatty acids and the distribution of double bonds in these acids resembled those of ruminant fats. Because trans-11-18:1 was the main trans-18:1 isomer of beaver fat and a conjugated diene cis-9, trans-11-18:2 was also detected, it can be deduced that linoleic acid (cis-9, cis-12-18:2) is biohydrogenated in the beaver. The ideas that microbial processes intervene before normal absorption and fatty acid metabolism of the beaver is also supported by the larger amounts of anteiso odd-chain fatty acids with respect to the corresponding iso acids in the beaver depots. In addition, the distribution of double bonds in the cis-octadecenoic acids was wide, as it is in the depot fats of ruminants.

  8. Treatment of central precocious puberty with triptorelin 11.25 mg depot formulation.

    PubMed

    Martínez-Aguayo, A; Hernández, M I; Beas, F; Iñiguez, G; Avila, A; Sovino, H; Bravo, E; Cassorla, F

    2006-08-01

    A new triptorelin 11.25 mg long depot formulation is now available for the treatment of central precocious puberty (CPP). The aim of our study was to evaluate the efficacy of triptorelin 11.25 mg administered every 90 days to suppress gonadotropin and sex steroid secretion and pubertal signs in children with CPP during 2 years of treatment. Inclusion criteria were clinical pubertal development before the age of 8 years in girls or 9 years in boys, advanced bone age and a pubertal LH response (peak >5 mIU/ml) to GnRH. We studied 20 patients (19 girls and 1 boy), with a median age at entry into the study of 7.5 +/- 0.2 years for girls, and 9 years for the boy. The basal and GnRH-stimulated serum levels of LH and FSH decreased significantly from baseline to 3 months of therapy (p <0.0001). All patients had a GnRH-stimulated peak below 3 mIU/ml between 6 and 24 months of treatment. The pituitary-gonadal axis recovered adequately after discontinuation of therapy. These results suggest that 3-month depot triptorelin is a satisfactory alternative for the therapy of children with CPP. The longer interval between injections may increase acceptability and compliance with treatment.

  9. [A preliminary study of low dosage zuclopenthixol depot in Alzheimer's disease].

    PubMed

    Robles, A; Rodríguez Navarrete, F J; Taboada, O; Docasar, L; Páramo, M; Noya, M

    1996-03-01

    Persistent psychomotor agitation and psychotic ideation in patients with Alzheimer's disease are normally treated orally with antipsychotic drugs and are occasionally treated with other drugs. Neuroleptics administered intramuscularly at very low doses are an alternative, especially when the patient rejects medicine as a results of his or her anosognosia or of paranoid manifestations. We present the results we obtained after observing the effects of depot zuclopenthixol in six patients with probable Alzheimer's disease (based upon NINCDS-ADRDA criteria). Psychic abnormalities were assessed as per the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS). Possible extrapyramidal side effects were evaluated by means of the Abnormal Involuntary Movement Scale (AIMS). Initially 60 mg (0.3 ml) were administered intramuscularly and successive doses could be modified by +/-20 mg (0.1 ml) according to results seen on the various scales. During the first six weeks of treatment progressive improvement was noted on all three psychic functions scales in all patients. Between the sixth and twelfth weeks improvement continued although without significant change. The AIMS did not show significant changes in the twelve weeks of follow-up. We consider depot zuclopenthixol at low doses as efficacious in treating persistent psychomotor agitation and/or psychotic manifestations of Alzheimer's disease. No undesired side effects were observed in our group after a twelve week follow-up.

  10. A Fuzzy Goal Programming for a Multi-Depot Distribution Problem

    NASA Astrophysics Data System (ADS)

    Nunkaew, Wuttinan; Phruksaphanrat, Busaba

    2010-10-01

    A fuzzy goal programming model for solving a Multi-Depot Distribution Problem (MDDP) is proposed in this research. This effective proposed model is applied for solving in the first step of Assignment First-Routing Second (AFRS) approach. Practically, a basic transportation model is firstly chosen to solve this kind of problem in the assignment step. After that the Vehicle Routing Problem (VRP) model is used to compute the delivery cost in the routing step. However, in the basic transportation model, only depot to customer relationship is concerned. In addition, the consideration of customer to customer relationship should also be considered since this relationship exists in the routing step. Both considerations of relationships are solved using Preemptive Fuzzy Goal Programming (P-FGP). The first fuzzy goal is set by a total transportation cost and the second fuzzy goal is set by a satisfactory level of the overall independence value. A case study is used for describing the effectiveness of the proposed model. Results from the proposed model are compared with the basic transportation model that has previously been used in this company. The proposed model can reduce the actual delivery cost in the routing step owing to the better result in the assignment step. Defining fuzzy goals by membership functions are more realistic than crisps. Furthermore, flexibility to adjust goals and an acceptable satisfactory level for decision maker can also be increased and the optimal solution can be obtained.

  11. Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate.

    PubMed

    Sartorius, Gideon; Fennell, Carolyn; Spasevska, Sasa; Turner, Leo; Conway, Ann J; Handelsman, David J

    2010-03-01

    Pain following depot intramuscular (IM) injection of oil vehicle-based drugs has been little studied. This study aimed to determine prospectively the prevalence, determinants, severity and functional consequences of pain during the week after IM injection of 1 000 mg testosterone undecanoate (TU) in a 4-mL castor oil vehicle. Androgen-deficient men receiving regular T replacement therapy at an academic andrology clinic were recruited to report pain scores using a coloured visual linear analogue scale at seven times over the first day and daily for a week after a deep IM gluteal injection. The time course and covariables influencing pain scores were analysed by mixed model analysis of variance (ANOVA). Following 168 injections in 125 men, pain was reported by 80% of men, peaking immediately after injection, reaching only moderate severity, lasting 1-2 days and returning to baseline by day 4. The pain required little analgesic use and produced minimal interference in daily activities. The time course of pain scores was reproducible in the 43 men who underwent two consecutive injections. Pain was more severe in men who had an earlier painful injection, but less severe in older and more obese men. There were negligible differences in post-injection pain experience between experienced nurses administering injections. Deep IM gluteal injection of depot TU in 4-mL castor oil is well tolerated and post-injection pain is influenced by earlier painful injection experience, as well as age and obesity.

  12. Appraisal of shallow ground-water resources, Pueblo Army Depot, Colorado

    USGS Publications Warehouse

    Welder, Frank A.; Hurr, R. Theodore

    1972-01-01

    The water supply for the Pueblo Army Depot, 15 miles wast of Pueblo, Colo., is obtained from wells that tap an aquifer in terrace alluvium. Withdrawals have resulted in a water-level decline of 27 feet, which adversely affects the discharge rate of individual wells. Furthermore, excessive pumpage has resulted in progressive deterioration of water quality. Over a 20-year period, hardness has increased from 70 milligrams per liter to 135 milligrams per liter and dissolved-solids content has increased from 250 milligrams per liter to 370 milligrams per liter. Two new supply wells were drilled in the southern part of the Depot and were tested to determine aquifer properties and probable production rate. The hydraulic conductivity determined from these tests ranged from about 350 to nearly 600 gallons per day per square foot. The transmissivity for the full thickness of the aquifer is in the range of 7,500 to 12,000 gallons per day per foot. The two new supply wells can be pumped at a combined rate of about 140 gallons per minute. If pumpage in the existing well field is reduced by the same amount, some recovery of water levels in the field will occur and the trend in water quality deterioration may slow or even reverse.

  13. Naltrexone depot formulations for opioid and alcohol dependence: a systematic review.

    PubMed

    Lobmaier, Philipp P; Kunøe, Nikolaj; Gossop, Michael; Waal, Helge

    2011-12-01

    Naltrexone is an opioid receptor antagonist that blocks the reinforcing effects of opioids and reduces alcohol consumption and craving. It has no abuse potential, mild and transient side effects, and thus appears an ideal pharmacotherapy for opioid dependence. Its effectiveness in alcohol dependence is less evident, but compliance with naltrexone combined with psychosocial support has been repeatedly shown to improve drinking outcomes. Limited compliance with oral naltrexone treatment is a known drawback. Several naltrexone implant and injectable depot formulations are being investigated and provide naltrexone release for at least 1 month. Studies among opioid-dependent patients indicate significant reductions in heroin use, but sample sizes are usually small. In alcohol dependence, two large multicenter trials report alcohol and craving reductions for naltrexone and placebo groups, indicating a significant but moderate effect. The pharmacokinetic profile of the injectable formulation indicates reliable naltrexone release over 1 month at therapeutic levels. Implant formulations releasing naltrexone up to 7 months are reported. Findings on safety and tolerability confirm the generally mild adverse effects described for naltrexone tablets. However, further research on therapeutic levels (i.e., opioid blocking) is warranted. The majority of naltrexone implants lacks approval for regular clinical use and larger longitudinal studies are needed. The available naltrexone depot formulations have the potential to significantly improve medication compliance in opioid and alcohol dependence. In certain circumstances, they may constitute a promising new treatment option. © 2010 Blackwell Publishing Ltd.

  14. Acute Hypercortisolemia Exerts Depot-Specific Effects on Abdominal and Femoral Adipose Tissue Function.

    PubMed

    Manolopoulos, Konstantinos N; O'Reilly, Michael W; Bujalska, Iwona J; Tomlinson, Jeremy W; Arlt, Wiebke

    2017-04-01

    Glucocorticoids have pleiotropic metabolic functions, and acute glucocorticoid excess affects fatty acid metabolism, increasing systemic lipolysis. Whether glucocorticoids exert adipose tissue depot-specific effects remains unclear. To provide an in vivo assessment of femoral and abdominal adipose tissue responses to acute glucocorticoid administration. Nine healthy male volunteers were studied on two occasions, after a hydrocortisone infusion (0.2 mg/kg/min for 14 hours) and a saline infusion, respectively, given in randomized double-blind order. The subjects were studied in the fasting state and after a 75-g glucose drink with an in vivo assessment of femoral adipose tissue blood flow (ATBF) using radioactive xenon washout and of lipolysis and glucose uptake using the arteriovenous difference technique. In a separate study (same infusion design), eight additional healthy male subjects underwent assessment of fasting abdominal ATBF and lipolysis only. Lipolysis was assessed as the net release of nonesterified fatty acids (NEFAs) from femoral and abdominal subcutaneous adipose tissue. Acute hypercortisolemia significantly increased basal and postprandial ATBF in femoral adipose tissue, but the femoral net NEFA release did not change. In abdominal adipose tissue, hypercortisolemia induced substantial increases in basal ATBF and NEFA release. Acute hypercortisolemia induces differential lipolysis and ATBF responses in abdominal and femoral adipose tissue, suggesting depot-specific glucocorticoid effects. Abdominal, but not femoral, adipose tissue contributes to the hypercortisolemia-induced systemic NEFA increase, with likely contributions from other adipose tissue sources and intravascular triglyceride hydrolysis.

  15. Algorithms for Heterogeneous, Multiple Depot, Multiple Unmanned Vehicle Path Planning Problems

    SciTech Connect

    Sundar, Kaarthik; Rathinam, Sivakumar

    2016-12-26

    Unmanned vehicles, both aerial and ground, are being used in several monitoring applications to collect data from a set of targets. This article addresses a problem where a group of heterogeneous aerial or ground vehicles with different motion constraints located at distinct depots visit a set of targets. The vehicles also may be equipped with different sensors, and therefore, a target may not be visited by any vehicle. The objective is to find an optimal path for each vehicle starting and ending at its respective depot such that each target is visited at least once by some vehicle, the vehicle–target constraints are satisfied, and the sum of the length of the paths for all the vehicles is minimized. Two variants of this problem are formulated (one for ground vehicles and another for aerial vehicles) as mixed-integer linear programs and a branchand- cut algorithm is developed to compute an optimal solution to each of the variants. Computational results show that optimal solutions for problems involving 100 targets and 5 vehicles can be obtained within 300 seconds on average, further corroborating the effectiveness of the proposed approach.

  16. Genital Injury Signatures and Microbiome Alterations Associated With Depot Medroxyprogesterone Acetate Usage and Intravaginal Drying Practices.

    PubMed

    Birse, Kenzie D; Romas, Laura M; Guthrie, Brandon L; Nilsson, Peter; Bosire, Rose; Kiarie, James; Farquhar, Carey; Broliden, Kristina; Burgener, Adam D

    2017-02-15

    Increasing evidence suggests depot medroxyprogesterone acetate (DMPA) and intravaginal practices may be associated with human immunodeficiency virus (HIV-1) infection risk; however, the mechanisms are not fully understood. This study evaluated the effect of DMPA and intravaginal practices on the genital proteome and microbiome to gain mechanistic insights. Cervicovaginal secretions from 86 Kenyan women, including self-reported DMPA users (n = 23), nonhormonal contraceptive users (n = 63), and women who practice vaginal drying (n = 46), were analyzed using tandem-mass spectrometry. We identified 473 human and 486 bacterial proteins from 18 different genera. Depot medroxyprogesterone acetate use associated with increased hemoglobin and immune activation (HBD, HBB, IL36G), and decreased epithelial repair proteins (TFF3, F11R). Vaginal drying associated with increased hemoglobin and decreased phagocytosis factors (AZU1, MYH9, PLAUR). Injury signatures were exacerbated in DMPA users who also practiced vaginal drying. More diverse (H index: 0.71 vs 0.45; P = .009) bacterial communities containing Gardnerella vaginalis associated with vaginal drying, whereas DMPA showed no significant association with community composition or diversity. These findings provide new insights into the impact of DMPA and vaginal drying on mucosal barriers. Future investigations are needed to confirm their relationship with HIV risk in women.

  17. Algorithms for Heterogeneous, Multiple Depot, Multiple Unmanned Vehicle Path Planning Problems

    DOE PAGES

    Sundar, Kaarthik; Rathinam, Sivakumar

    2016-12-26

    Unmanned vehicles, both aerial and ground, are being used in several monitoring applications to collect data from a set of targets. This article addresses a problem where a group of heterogeneous aerial or ground vehicles with different motion constraints located at distinct depots visit a set of targets. The vehicles also may be equipped with different sensors, and therefore, a target may not be visited by any vehicle. The objective is to find an optimal path for each vehicle starting and ending at its respective depot such that each target is visited at least once by some vehicle, the vehicle–targetmore » constraints are satisfied, and the sum of the length of the paths for all the vehicles is minimized. Two variants of this problem are formulated (one for ground vehicles and another for aerial vehicles) as mixed-integer linear programs and a branchand- cut algorithm is developed to compute an optimal solution to each of the variants. Computational results show that optimal solutions for problems involving 100 targets and 5 vehicles can be obtained within 300 seconds on average, further corroborating the effectiveness of the proposed approach.« less

  18. Fuel compositions

    SciTech Connect

    Zaweski, E.F.; Niebylski, L.M.

    1986-08-05

    This patent describes distillate fuel for indirect injection compression ignition engines containing, in an amount sufficient to minimize coking, especially throttling nozzle coking in the prechambers or swirl chambers of indirect injection compression ignition engines operated on such fuel, at least the combination of (i) organic nitrate ignition accelerator and (ii) an esterified cycle dehydration product of sorbitol which, when added to the fuel in combination with the organic nitrate ignition accelerator minimizes the coking.

  19. Fuel cells 101

    SciTech Connect

    Hirschenhofer, J.H.

    1999-07-01

    This paper discusses the various types of fuel cells, the importance of cell voltage, fuel processing for natural gas, cell stacking, fuel cell plant description, advantages and disadvantages of the types of fuel cells, and applications. The types covered include: polymer electrolyte fuel cell, alkaline fuel cell, phosphoric acid fuel cell; molten carbonate fuel cell, and solid oxide fuel cell.

  20. Motor fuel

    SciTech Connect

    Burns, L.D.

    1982-07-13

    Liquid hydrocarbon fuel compositions are provided containing antiknock quantities of ashless antiknock agents comprising selected furyl compounds including furfuryl alcohol, furfuryl amine, furfuryl esters, and alkyl furoates.

  1. Fuel dehazers

    SciTech Connect

    Lyons, W.R.

    1986-03-01

    Hazy fuels can be caused by the emulsification of water into the fuel during refining, blending, or transportation operations. Detergent additive packages used in gasoline tend to emulsify water into the fuel. Fuels containing water haze can cause corrosion and contamination, and support microbiological growth. This results in problems. As the result of these problems, refiners, marketers, and product pipeline companies customarily have haze specifications. The haze specification may be a specific maximum water content or simply ''bright and clear'' at a specified temperature.

  2. Alternative fuels

    SciTech Connect

    Not Available

    1991-07-01

    This paper presents the preliminary results of a review, of the experiences of Brazil, Canada, and New Zealand, which have implemented programs to encourage the use of alternative motor fuels. It will also discuss the results of a separate completed review of the Department of Energy's (DOE) progress in implementing the Alternative Motor Fuels Act of 1988. The act calls for, among other things, the federal government to use alternative-fueled vehicles in its fleet. The Persian Gulf War, environmental concerns, and the administration's National Energy Strategy have greatly heightened interest in the use of alternative fuels in this country.

  3. 76 FR 35379 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island, SC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... located adjacent to the rifle range and pistol range at the U.S. Marine Corps Recruit Depot Parris Island... operation of the existing rifle and pistol ranges. DATES: Written comments must be received on or before... fire warning signs will continue to be used to ensure safe navigation in the vicinity of the rifle and...

  4. Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies.

    PubMed

    Zhang, Mingzhi; Hu, Tian; Zhang, Shaoyan; Zhou, Li

    2015-12-21

    Fat distribution is strongly associated with insulin resistance, a risk factor for type 2 diabetes and cardiovascular diseases. However, associations of different adipose tissue depots or/and obesity indices with insulin resistance have not been systematically evaluated. In this study we examined associations of different adipose tissue depots/obesity indices with insulin resistance, as measured by homeostatic model assessment of insulin resistance (HOMA-IR) in observational studies. A total of 40 studies with 56 populations and 29 adipose tissue depots/obesity indices were included in the meta-analysis. There were strong correlation between HOMA-IR and visceral fat mass (r = 0.570, 95% confidence interval(CI): 0.424~0.687), total fat mass (r = 0.492, 95%CI: 0.407~0.570), body mass index (r = 0.482, 95%CI: 0.445~0.518) and waist circumference (r = 0.466, 95%CI: 0.432~0.500), except lower extremity fat (r = 0.088, 95%CI: -0.116~0.285). Sample size, diabetic status, gender, mean of body mass index, and race contributed to heterogeneity of these associations. This study showed a positive correlation between insulin resistance and most adipose tissue depots/obesity indices, and the strongest association is for visceral fat mass.

  5. Six-month gonadotropin releasing hormone (GnRH) agonist depots provide efficacy, safety, convenience, and comfort

    PubMed Central

    Crawford, E David; Phillips, Jason M

    2011-01-01

    Two different 6-month GnRH agonist depot formulations approved for palliative treatment of advanced and metastatic prostate cancer in the United States – leuprolide acetate 45 mg and triptorelin pamoate 22.5 mg – provide patients with efficacy and safety comparable to those of existing 1-, 3-, and 4-month GnRH agonist depots. However, the 6-month formulations can increase patient convenience, comfort, and compliance by reducing the number of physician visits and injections required. At the conclusion of their pivotal trials, the 6-month formulations demonstrated efficacy rates in achieving chemical castration (serum testosterone ≤50 ng/dL) that ranged between 93% and 99%. As with existing GnRH agonist depot formulations, hot flashes represented the most common adverse event reported in trials of 6-month leuprolide acetate or triptorelin. As such, these products may prove useful not only for their labeled indication, but also as adjuncts to other treatments such as radical prostatectomy, radiotherapy, and chemotherapy. We recommend further research, including head-to-head trials between the 6-month GnRH depots, to refine our understanding of these products. PMID:21847353

  6. Perceptions on efficacy and side effects of conventional depot antipsychotics (CDA) and atypical depot antipsychotics (ADA): Psychiatrists versus patients in Hong Kong.

    PubMed

    Tsang, Hector W H; Fong, Mandy W M; Fung, Kelvin M T; Chung, Raymond C K

    2010-03-01

    Abstract Objectives. We compared the satisfaction level of psychiatrists and psychiatric patients towards conventional (CDA) and atypical (ADA) depot antipsychotics on symptom management, role functioning, and side effects. Method. Patients from an out-patient clinic of a public hospital and psychiatrists from public hospitals participated in the survey in 2007-2008. A total of 153 patients were interviewed by a tailor-made questionnaire and 72 psychiatrists self-administered a similar questionnaire. Results. Both groups shared similar attitudes towards clinical effectiveness and treatment efficacy of ADA and CDA. More patients were ambivalent towards relapse prevention of CDA than psychiatrists (30.7 vs. 16.7%, P<0.044) and three quarters of psychiatrists believed that ADA are associated with less side effects. More than half of the patients showed negative attitudes towards the effectiveness of CDA on improving quality of life (52.40%), work (57.50%), and recreation (55.50%). Psychiatrists were more aware of the limitation of CDA and severity of side effects of CDA. They did not, however, seem to incorporate patients' opinions and research findings into their clinical practice. Conclusion. Evidence-based practice and shared decision-making model between clinicians and mental patients should be advocated. More investigations should be devoted to examine the efficacy of ADA as the alternative to CDA.

  7. The effects of metabolizable energy intake on body fat depots of adult Pelibuey ewes fed roughage diets under tropical conditions.

    PubMed

    Chay-Canul, A J; Ayala-Burgos, A J; Ku-Vera, J C; Magaña-Monforte, J G; Tedeschi, L O

    2011-06-01

    The objective of this work was to evaluate the effect of metabolizable energy intake (MEI) on changes in fat depots of adult Pelibuey ewes fed roughage diets under tropical conditions. Eighteen 3-year-old Pelibuey ewes with similar body weight (BW) of 37.6 ± 4.0 kg and body condition score (BCS) of 2.5 ± 0.20 were randomly assigned to three groups of six ewes each in a completely randomized design. Ewes were housed in metabolic crates and fed three levels of MEI: low (L), medium (M), and high (H) for 65 days to achieve different BW and BCS. At the end of the experiment, the ewes were slaughtered. Data recorded at slaughter were: weights of viscera and carcass. Internal fat (IF, internal adipose tissue) was dissected, weighed, and grouped as pelvic (around kidneys and pelvic region), omental, and mesenteric regions. Carcass was split at the dorsal midline in two equal halves, weighed, and chilled at 6°C during 24 h. After refrigeration, the left half of the carcass was completely dissected into subcutaneous and intermuscular fat (carcass fat). Dissected carcass fat (CF) of the left carcass was adjusted as whole carcass. At low levels of MEI, proportion of IF and CF was approximately 50%; however, as the MEI was increased, the proportion of IF was increased up to 57% and 60% for M and H, respectively. Omental and pelvic fat depots were those which increased in a larger proportion with respect to the mesenteric fat depot. Regression equations between the weight of each body fat depot and BW had a coefficient of determination (r (2)) that ranged between 0.37 for mesenteric fat and 0.87 for CF. The regression with BCS had a r (2) that ranged between 0.57 for mesenteric and 0.71 for TBF. BW was the best predictor for TBF, CF, omental fat, and pelvic fat; whereas, BCS was better than BW in predicting IF and mesenteric fat. Inclusion of both BW and BCS in multiple regressions improved the prediction for all fat depots, except for pelvic fat, which was best

  8. Isotopic Details of the Spent Catawba-1 MOX Fuel Rods at ORNL

    SciTech Connect

    Ellis, Ronald James

    2015-04-01

    The United States Department of Energy funded Shaw/AREVA MOX Services LLC to fabricate four MOX Lead Test Assemblies (LTA) from weapons-grade plutonium. A total of four MOX LTAs (including MX03) were irradiated in the Catawba Nuclear Station (Unit 1) Catawba-1 PWR which operated at a total thermal power of 3411 MWt and had a core with 193 total fuel assemblies. The MOX LTAs were irradiated along with Duke Energy s irradiation of eight Westinghouse Next Generation Fuel (NGF) LEU LTAs (ref.1) and the remaining 181 LEU fuel assemblies. The MX03 LTA was irradiated in the Catawba-1 PWR core (refs.2,3) during cycles C-16 and C-17. C-16 began on June 5, 2005, and ended on November 11, 2006, after 499 effective full power days (EFPDs). C-17 started on December 29, 2006, (after a shutdown of 48 days) and continued for 485 EFPDs. The MX03 and three other MOX LTAs (and other fuel assemblies) were discharged at the end of C-17 on May 3, 2008. The design of the MOX LTAs was based on the (Framatome ANP, Inc.) Mark-BW/MOX1 17 17 fuel assembly design (refs. 4,5,6) for use in Westinghouse PWRs, but with MOX fuel rods with three Pu loading ranges: the nominal Pu loadings are 4.94 wt%, 3.30 wt%, and 2.40 wt%, respectively, for high, medium, and low Pu content. The Mark-BW/MOX1 (MOX LTA) fuel assembly design is the same as the Advanced Mark-BW fuel assembly design but with the LEU fuel rods replaced by MOX fuel rods (ref. 5). The fabrication of the fuel pellets and fuel rods for the MOX LTAs was performed at the Cadarache facility in France, with the fabrication of the LTAs performed at the MELOX facility, also in France.

  9. Fuel injector

    DOEpatents

    Lambeth, Malcolm David Dick

    2001-02-27

    A fuel injector comprises first and second housing parts, the first housing part being located within a bore or recess formed in the second housing part, the housing parts defining therebetween an inlet chamber, a delivery chamber axially spaced from the inlet chamber, and a filtration flow path interconnecting the inlet and delivery chambers to remove particulate contaminants from the flow of fuel therebetween.

  10. Future Fuels

    DTIC Science & Technology

    2006-04-01

    financing, push technology and help motivate the building of the necessary manufacturing and distribution infrastructure. Hybrid Electric Vehicles , Tether...conclusions in three major areas: Hybrid Electric Vehicles (HEVs), fuel management during combat operations and manufactured fuels to address the...payoffs in the relatively near term, are: • Hybrid Electric Vehicles : The development of and commitment to hybrid electric architecture for TWVs

  11. Final Environmental Assessment for the Disposal of the Former Lynn Haven Fuel Depot, Tyndall Air Force Base, Florida

    DTIC Science & Technology

    2015-12-01

    soils ), hazardous materials and waste (i.e., hazardous materials, hazardous waste, and the Air Force’s Environmental Restoration Program), and cultural...Through the EA analysis, Proposed Action Alternative 1 has been determined to be the only practicable alternative. Land use soil restrictions limit the...USFWS), National Marine Fisheries Service, United States Army Corps of Engineers, and Native American Tribes/Nations that expressed an interest in

  12. The cytotoxic effect of wastewater from the phosphoric gypsum depot on common oak (Quercus robur L.) and shallot (Allium cepa var. ascalonicum).

    PubMed

    Pavlica, M; Besendorfer, V; Rosa, J; Papes, D

    2000-11-01

    The effect of wastewater from a phosphoric gypsum depot on common oak, Quercus robur L., at cytogenetical level was studied. Allium-test was used as a control. The treatment of common oak seedlings with wastewater under laboratory conditions caused mitodepressive effect. Chromosome aberrations and mitotic irregularities were found. Cytogenetic analysis of common oak seedlings grown from acorns collected near the depot did not show changes in mitotic activity in comparison to control but the number of aberrations was higher than in control. In comparison to Alliumtest common oak was found to be more tolerant to wastewater from the phosphoric gypsum depot.

  13. Flow of Power-Law Liquids in a Hele-Shaw Cell Driven by Non-Uniform Electroosmotic Slip in the Case of Strong Depletion

    NASA Astrophysics Data System (ADS)

    Boyko, Evgeniy; Bercovici, Moran; Gat, Amir

    2016-11-01

    We analyze flow of a non-Newtonian fluid in a Hele-Shaw cell, subjected to spatially non-uniform electroosmotic flow. We specifically focus on power-law fluids with wall depletion properties and derive a p-Poisson equation governing the pressure field, as well as a set of linearized equations representing its asymptotic approximation for weakly non-Newtonian behavior. To investigate the effect of non-Newtonian properties on the resulting fluidic pressure and velocity, we consider several configurations in one and two dimensions, and calculate both exact and approximate solutions. We show that the asymptotic approximation is in good agreement with exact solutions even for fluids with significant non-Newtonian behavior. The asymptotic model thus enables prediction of the flow and pressure fields for non-Newtonian fluids, and may be particularly useful for the analysis and design of microfluidic systems involving electro-kinetic transport of such fluids.

  14. Flow of power-law liquids in a Hele-Shaw cell driven by non-uniform electro-osmotic slip in the case of strong depletion

    NASA Astrophysics Data System (ADS)

    Boyko, Evgeniy; Bercovici, Moran; Gat, Amir D.

    2016-11-01

    We analyze flow of non-Newtonian fluids in a Hele-Shaw cell, subjected to spatially non-uniform electroosmotic slip. Motivated by their potential use for increasing the characteristic pressure fields, we specifically focus on power-law fluids with wall depletion properties. We derive a p-Poisson equation governing the pressure field, as well as a set of linearized equations representing its asymptotic approximation for weakly non-Newtonian behavior. To investigate the effect of non-Newtonian properties on the resulting fluidic pressure and velocity, we consider several configurations in one- and two-dimensions, and calculate both exact and approximate solutions. We show that the asymptotic approximation is in good agreement with exact solutions even for fluids with significant non-Newtonian behavior, allowing its use in the analysis and design of microfluidic systems involving electro-kinetic transport of such fluids.

  15. Fuel cell-fuel cell hybrid system

    DOEpatents

    Geisbrecht, Rodney A.; Williams, Mark C.

    2003-09-23

    A device for converting chemical energy to electricity is provided, the device comprising a high temperature fuel cell with the ability for partially oxidizing and completely reforming fuel, and a low temperature fuel cell juxtaposed to said high temperature fuel cell so as to utilize remaining reformed fuel from the high temperature fuel cell. Also provided is a method for producing electricity comprising directing fuel to a first fuel cell, completely oxidizing a first portion of the fuel and partially oxidizing a second portion of the fuel, directing the second fuel portion to a second fuel cell, allowing the first fuel cell to utilize the first portion of the fuel to produce electricity; and allowing the second fuel cell to utilize the second portion of the fuel to produce electricity.

  16. A Case of Mental Retardation with Paraphilia Treated with Depot Leuprorelin

    PubMed Central

    Park, Woo Sung; Kim, Kyung Min; Jung, Yong Woo

    2014-01-01

    Paraphilia is a psychiatric disease that has been difficult to cure. However, recently developed therapeutic methods hold promise. The patient was a 20-yr-old male with chief complaints of continuous masturbation, genital exposure, and aggressive behavior that started 2 yr ago. We administered leuprorelin 3.6 mg intramuscular injection per month, a depot gonadotrophin-releasing hormone analogue, to this patient who a severe mentally retardation with paraphilia. The clinical global impression (CGI)-severity, CGI-improvement and aberrant behavior checklist were performed. After one month, we observed significant improvement in symptoms, such as decreases of abnormal sexual behavior and sexual desire. The GnRH analogues are suggested to be used as an alternative or supplementary therapeutic method for sexual offenders after clinical studies. Graphical Abstract PMID:25246754

  17. Thermal Optimization of an On-Orbit Long Duration Cryogenic Propellant Depot

    NASA Technical Reports Server (NTRS)

    Honour, Ryan; Kwas, Robert; O'Neil, Gary; Kutter, Gary

    2012-01-01

    A Cryogenic Propellant Depot (CPD) operating in Low Earth Orbit (LEO) could provide many near term benefits to NASA's space exploration efforts. These benefits include elongation/extension of spacecraft missions and requirement reduction of launch vehicle up-mass. Some of the challenges include controlling cryogenic propellant evaporation and managing the high costs and long schedules associated with the new development of spacecraft hardware. This paper describes a conceptual CPD design that is thermally optimized to achieve extremely low propellant boil-off rates. The CPD design is based on existing launch vehicle architecture, and its thermal optimization is achieved using current passive thermal control technology. Results from an integrated thermal model are presented showing that this conceptual CPD design can achieve propellant boil-off rates well under 0.05% per day, even when subjected to the LEO thermal environment.

  18. Depot medroxyprogesterone acetate contraception and the risk of breast and gynecologic cancer.

    PubMed

    Kaunitz, A M

    1996-05-01

    As the use of depot medroxyprogesterone acetate (DMPA) contraception increases in the United States and worldwide, assessing any impact on the risk of breast and gynecologic cancers becomes increasingly important. Overall, use of DMPA does not affect breast cancer risk. An elevated risk of this disease, however, has been noted in recent or current users. Hence, the association between DMPA use and breast cancer risk appears similar to that observed with oral contraceptives. Use of DMPA is associated with an 80% risk reduction of endometrial adenocarcinoma, a level of protection even greater than that noted with oral contraceptives. The risk of epithelial ovarian cancer and cervical neoplasia does not appear to be affected by DMPA use. Except for a substantial reduction in the risk of endometrial adenocarcinoma, use of DMPA does not appear to influence reproductive tract cancer risks.

  19. Abdominal fat sub-depots and energy expenditure: Magnetic resonance imaging study.

    PubMed

    Serfaty, Dana; Rein, Michal; Schwarzfuchs, Dan; Shelef, Ilan; Gepner, Yftach; Bril, Nitzan; Cohen, Noa; Shemesh, Elad; Sarusi, Benjamin; Kovsan, Julia; Kenigsbuch, Shira; Chassidim, Yoash; Golan, Rachel; Witkow, Shula; Henkin, Yaakov; Stampfer, Meir J; Rudich, Assaf; Shai, Iris

    2017-06-01

    We aimed to assess the association between the distinct abdominal sub-depots and resting energy expenditure (REE). We performed magnetic resonance imaging (MRI) to quantify abdominal visceral-adipose-tissue (VAT), deep-subcutaneous-adipose-tissue (deep-SAT), and superficial-subcutaneous-adipose-tissue (superficial-SAT). We measured REE by indirect-calorimetry. Non-exercise activity thermogenesis (NEAT) [1-3 metabolic equivalents (METs)] and exercise thermogenesis (activities of 4+METS) were estimated based on 6-days of accelerometry to assess total physical activity energy expenditure (PAEE). We studied 282 participants: 249 men [mean age = 47.4 years, body-mass-index (BMI) = 31 kg/m(2), mean VAT proportion from total abdominal fat = 34.5%, mean superficial-SAT proportion from total abdominal fat = 24.3%] and 33 women (mean age = 51.2 years, BMI = 30.1 kg/m(2), mean VAT proportion from total abdominal fat = 22.8%, mean superficial-SAT proportion from total abdominal fat = 37.8%). As expected, women had lower REE [by 32.4% (1488 ± 234 kcal/day vs. 1971 ± 257 kcal/day; p < 0.01)] and lower REE/kg [by 8% (19.6 ± 3 kcal/kg vs. 21.2 ± 2 kcal/kg; p < 0.01)] than men. Exercise and total PAEE were positively associated with REE/kg (p < 0.01 for both) and a positive correlation between NEAT and REE/kg was borderline (p = 0.056). Participants, in whom abdominal VAT was the dominant proportional depot, had higher REE (1964 ± 297 kcal/day vs. 1654 ± 352 kcal/day; p < 0.01) and higher REE∖kg (22.2 ± 2.3 kcal/kg/day vs. 19.6 ± 2.5 kcal/kg/day; p < 0.01) than participants in whom superficial-SAT was the largest proportional depot. In multivariate models, adjusted for age, gender and residual BMI, increased VAT proportion was independently associated with higher REE (β = 0.181; p = 0.05). Likewise, increased VAT proportion (β = 0.482; p < 0.01) remained independently associated with higher REE/kg. In this

  20. Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots.

    PubMed

    Di, Jin; Yao, Shanshan; Ye, Yanqi; Cui, Zheng; Yu, Jicheng; Ghosh, Tushar K; Zhu, Yong; Gu, Zhen

    2015-09-22

    Mechanical force-based stimulus provides a simple and easily accessible manner for spatiotemporally controlled drug delivery. Here we describe a wearable, tensile strain-triggered drug delivery device consisting of a stretchable elastomer and microgel depots containing drug loaded nanoparticles. By applying a tensile strain to the elastomer film, the release of drug from the microdepot is promoted due to the enlarged surface area for diffusion and Poisson's ratio-induced compression on the microdepot. Correspondingly, both sustained drug release by daily body motions and pulsatile release by intentional administration can be conveniently achieved. Our work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. Moreover, polymeric microneedles were further integrated with the stretch-responsive device for transcutaneous delivery of insulin and regulation of blood glucose levels of chemically induced type 1 diabetic mice.

  1. Thermal Optimization and Assessment of a Long Duration Cryogenic Propellant Depot

    NASA Technical Reports Server (NTRS)

    Honour, Ryan; Kwas, Robert; O'Neil, Gary; Kutter, Bernard

    2012-01-01

    A Cryogenic Propellant Depot (CPD) operating in Low Earth Orbit (LEO) could provide many near term benefits to NASA space exploration efforts. These benefits include elongation/extension of spacecraft missions and reduction of launch vehicle up-mass requirements. Some of the challenges include controlling cryogenic propellant evaporation and managing the high costs and long schedules associated with new spacecraft hardware development. This paper describes a conceptual CPD design that is thermally optimized to achieve extremely low propellant boil-off rates. The CPD design is based on existing launch vehicle architecture, and its thermal optimization is achieved using current passive thermal control technology. Results from an integrated thermal model are presented showing that this conceptual CPD design can achieve propellant boil-off rates well under 0.05% per day, even when subjected to the LEO thermal environment.

  2. [Long-term moditen-depot treatment of schizophrenic patients at a psychoneurology dispensary].

    PubMed

    Abramova, L I; Gushanskiĭ, E L

    1986-01-01

    In 31 patients with paroxysm-like progressive and 19 with continuously progressive paranoid schizophrenia the authors examined the results of long-term (from 4 to 11 years) treatment with moditen depot. The mean dosage of the drug was 25-50 mg per 3-4 weeks. A good therapeutic response was observed in more than half the cases. In group I patients it was expressed in the absence of relapses, improvement of quality and increase in the duration of the remissions; in group II it was expressed in an increased tendency toward a regressing course with a reduced intensity of processional manifestations. A favourable effect was accompanied by improved social and occupational adaptation of patients.

  3. A case of mental retardation with paraphilia treated with depot leuprorelin.

    PubMed

    Park, Woo Sung; Kim, Kyung Min; Jung, Yong Woo; Lim, Myung Ho

    2014-09-01

    Paraphilia is a psychiatric disease that has been difficult to cure. However, recently developed therapeutic methods hold promise. The patient was a 20-yr-old male with chief complaints of continuous masturbation, genital exposure, and aggressive behavior that started 2 yr ago. We administered leuprorelin 3.6 mg intramuscular injection per month, a depot gonadotrophin-releasing hormone analogue, to this patient who a severe mentally retardation with paraphilia. The clinical global impression (CGI)-severity, CGI-improvement and aberrant behavior checklist were performed. After one month, we observed significant improvement in symptoms, such as decreases of abnormal sexual behavior and sexual desire. The GnRH analogues are suggested to be used as an alternative or supplementary therapeutic method for sexual offenders after clinical studies.

  4. Medical Cosmopolitanism in Global Dubai: A Twenty-first-century Transnational Intracytoplasmic Sperm Injection (ICSI) Depot.

    PubMed

    Inhorn, Marcia C

    2017-03-01

    Dubai-one of the seven United Arab Emirates and the Middle East's only "global city"-is gaining a reputation as a transnational medical tourism hub. Characterized by its "medical cosmopolitanism," Dubai is now attracting medical travelers from around the world, some of whom are seeking assisted conception. Dubai is fast becoming known as a new transnational "reprohub" for intracytoplasmic sperm injection (ICSI), the variant of in vitro fertilization designed to overcome male infertility. Based on ethnographic research conducted in one of the country's most cosmopolitan clinics, this article explores the ICSI treatment quests of infertile men coming to Dubai from scores of other nations. The case of an infertile British-Moroccan man is highlighted to demonstrate why ICSI is a particularly compelling "masculine hope technology" for infertile Muslim men. Thus, Muslim men who face barriers to ICSI access in their home countries may become "reprotravelers" to Dubai, an emergent ICSI depot. © 2016 by the American Anthropological Association.

  5. Serum adipocytokines and adipose weight gain: a pilot study in adolescent females initiating depot medroxyprogesterone acetate.

    PubMed

    Bonny, Andrea E; Lange, Hannah L H; Hade, Erinn M; Kaufman, Bram; Reed, Michael D; Mesiano, Sam

    2015-10-01

    To evaluate whether serum adipocytokine concentrations, controlling for baseline adiposity, are predictive of adipose weight gain in adolescents initiating depot medroxyprogesterone acetate (DMPA). Percent body fat was measured at baseline and 6 months. Baseline serum adipocytokine concentrations were quantified. Mean percent body fat was 31.6% (±7.6) at baseline and 33.5% (±7.6) at 6 months. In multivariable linear regression modeling (adjusted for baseline percent body fat), Hispanic ethnicity and baseline serum adiponectin concentration were inversely associated (p≤.05) with absolute change in percent body fat at 6 months. Serum adiponectin concentration may be useful for assessing risk of DMPA-associated adipose gains. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Effect of Depot Medroxyprogesterone Acetate on Glucose Tolerance in Generalized Lipodystrophy

    PubMed Central

    Yauger, Belinda J.; Gorden, Phillip; Park, Jean; Cochran, Elaine; Stratton, Pamela

    2012-01-01

    BACKGROUND Lipodystrophy is a rare condition causing severe insulin resistance and frank diabetes. Depot medroxyprogesterone acetate (DMPA), a commonly used contraceptive, may worsen glucose tolerance in diabetics and those with lipodystrophy. CASE A young woman with generalized lipodystrophy, who previously required greater than 1,000 units of insulin daily, had a normal hemoglobin A1c on leptin and metformin only. After an injection of DMPA, she developed severe hyperglycemia. Her levels returned to near normal only with extremely high doses of insulin (up to 1,700 units/d) and increased doses of leptin and metformin. CONCLUSION Progestin-only contraceptives may detrimentally affect glucose tolerance, particularly in patients with lipodystrophy, a cause of severe insulin resistance and leptin deficiency. One DMPA injection appeared to profoundly alter glucose metabolism in this patient with frank diabetes resulting from lipodystrophy. The effect of progestin-only contraceptives on glucose tolerance should be monitored closely in any diabetic patient. PMID:18669758

  7. Depot-medroxyprogesterone acetate (DMPA) and cancer: Memorandum from a WHO Meeting*

    PubMed Central

    1986-01-01

    A review of all available data including those from the WHO Collaborative Study of Neoplasia and Steroid Contraceptives has shown no increased risk of cancers of the breast, endometrium, ovary or liver in women using depot-medroxyprogesterone acetate (DMPA). The issue of a causal association between DMPA use and cervical cancer is as yet unresolved and will require the accumulation of additional data. To date, in the WHO study only a small number of women have used DMPA for prolonged periods or have had a long interval since first use. Information on cancer risk in these women can only be gained by continuing the present study or by initiating additional studies focused on these specific topics. PMID:2945666

  8. Depot-medroxyprogesterone acetate (DMPA) and cancer: memorandum from a WHO meeting.

    PubMed Central

    1993-01-01

    Depot-medroxyprogesterone acetate (DMPA) is a long-acting progestational contraceptive, which is administered by injection. It was developed in the mid-1960s, when it was seen as a method that would be particularly useful for women seeking reversible contraception who had difficulty taking a pill every day. DMPA has been shown to be a highly effective contraceptive, and it has proved acceptable in a variety of settings. The drug is licensed as a contraceptive in more than 90 countries and has been widely used in a number of them, such as Thailand and New Zealand. On a worldwide basis, the licensing, acceptability, and prevalence of use have been influenced by concern that DMPA may increase the risk of cancer. Cancer of the breast has been a particular concern. This Memorandum reviews comprehensively the results of toxicological tests in animals and epidemiological studies in humans concerning the carcinogenicity of DMPA. PMID:8313485

  9. Disposal of chemical agents and munitions stored at Anniston Army Depot, Anniston, Alabama

    SciTech Connect

    Hunsaker, D.B. Jr.; Zimmerman, G.P.; Hillsman, E.L.; Miller, R.L.; Schoepfle, G.M.; Johnson, R.O.; Tolbert, V.R.; Kroodsma, R.L.; Rickert, L.W.; Rogers, G.O.; Staub, W.P.

    1990-09-01

    The purpose of this Phase I report is to examined the proposed implementation of on-site disposal at Anniston Army Depot (ANAD) in light of more detailed and more recent data than those included in the Final Programmatic Environmental Impact Statement (EPEIS). Two principal issues are addressed: (1) whether or not the new data would result in identification of on-site disposal at ANAD as the environmentally preferred alternative (using the same selection method and data analysis tools as in the FPEIS), and (2) whether or not the new data indicate the presence of significant environmental resources that could be affected by on-site disposal at ANAD. In addition, a status report is presented on the maturity of the disposal technology (and now it could affect on-site disposal at ANAD). Inclusion of these more recent data into the FPEIS decision method resulted in confirmation of on-site disposal for ANAD. No unique resources with the potential to prevent or delay implementation of on-site disposal at ANAD have been identified. A review of the technology status identified four principal technology developments that have occurred since publication of the FPEIS and should be of value in the implementation of on-site disposal at ANAD: the disposal of nonlethal agent at Pine Bluff Arsenal, located near Pine Bluff, Arkansas; construction and testing of facilities for disposal of stored lethal agent at Johnston Atoll, located about 1300 km (800 miles) southwest of Hawaii in the Pacific Ocean; lethal agent disposal tests at the chemical agent pilot plant operations at Tooele Army Depot, located near Salt Lake City, Utah; and equipment advances. 18 references, 13 figs., 10 tabs.

  10. Disposal of chemical agents and munitions stored at Umatilla Depot Activity, Hermiston, Oregon

    SciTech Connect

    Zimmerman, G.P.; Hillsman, E.L.; Johnson, R.O.; Miller, R.L.; Patton, T.G.; Schoepfle, G.M.; Tolbert, V.R.; Feldman, D.L.; Hunsaker, D.B. Jr.; Kroodsma, R.L.; Morrissey, J.; Rickert, L.W.; Staub, W.P.; West, D.C.

    1993-02-01

    The Umatilla Depot Activity (UMDA) near Hermiston, Oregon, is one of eight US Army installations in the continental United States where lethal unitary chemical agents and munitions are stored, and where destruction of agents and munitions is proposed under the Chemical Stockpile Disposal Program (CSDP). The chemical agent inventory at UMDA consists of 11.6%, by weight, of the total US stockpile. The destruction of the stockpile is necessary to eliminate the risk to the public from continued storage and to dispose of obsolete and leaking munitions. In 1988 the US Army issued a Final Programmatic Environmental Impact Statement (FPEIS) for the CSDP that identified on-site disposal of agents and munitions as the environmentally preferred alternative (i.e., the alternative with the least potential to cause significant adverse impacts), using a method based on five measures of risk for potential human health and ecosystem/environmental effects; the effectiveness and adequacy of emergency preparedness capabilities also played a key role in the FPEIS selection methodology. In some instances, the FPEIS included generic data and assumptions that were developed to allow a consistent comparison of potential impacts among programmatic alternatives and did not include detailed conditions at each of the eight installations. The purpose of this Phase 1 report is to examine the proposed implementation of on-site disposal at UMDA in light of more recent and more detailed data than those included in the FPEIS. Specifically, this Phase 1 report is intended to either confirm or reject the validity of on-site disposal for the UMDA stockpile. Using the same computation methods as in the FPEIS, new population data were used to compute potential fatalities from hypothetical disposal accidents. Results indicate that onsite disposal is clearly preferable to either continued storage at UMDA or transportation of the UMDA stockpile to another depot for disposal.

  11. Metformin induces glucose uptake in human preadipocyte-derived adipocytes from various fat depots.

    PubMed

    Fischer, M; Timper, K; Radimerski, T; Dembinski, K; Frey, D M; Zulewski, H; Keller, U; Müller, B; Christ-Crain, M; Grisouard, J

    2010-04-01

    To evaluate the effect of metformin on basal and insulin-induced glucose uptake in subcutaneous and visceral preadipocyte-derived adipocytes from obese and non-obese patients, preadipocytes were obtained from subcutaneous and visceral fat depots during abdominal surgery. Differentiation efficiency was evaluated by measurement of intracellular triglyceride accumulation. Preadipocyte-derived adipocytes were treated with metformin (1 mM) for 24 h with or without the addition of insulin (100 nM) for 20 min and glucose uptake was measured. In cells from each donor, intracellular triglyceride accumulation was more abundant in subcutaneous preadipocyte-derived adipocytes than in visceral preadipocyte-derived adipocytes (p < 0.001). Insulin stimulated glucose uptake in subcutaneous preadipocyte-derived adipocytes from both non-obese and obese patients (p < 0.001 vs. basal). In visceral preadipocyte-derived adipocytes, insulin did not increase basal glucose uptake. In subcutaneous preadipocyte-derived adipocytes from non-obese and obese patients, metformin alone increased glucose uptake to 2.7 +/- 0.2 (p < 0.001) and 2.1 +/- 0.1 fold (p < 0.001) respectively. Metformin increased glucose uptake in visceral preadipocyte-derived adipocytes from non-obese (1.7 +/- 0.1 fold vs. basal, p < 0.001) and obese (2.0 +/- 0.2 fold vs. basal, p < 0.001) patients. Combined treatment with metformin and insulin increased glucose uptake in subcutaneous preadipocyte-derived adipocytes from both non-obese and obese patients (p < 0.001 vs. insulin alone). In preadipocyte-derived adipocytes glucose uptake is induced by metformin independent of the fat depot origin of the preadipocytes (subcutaneous or visceral) and the obesity state of the patients (non-obese or obese). In adipocytes, metformin seems to induce glucose uptake independent of insulin suggesting an alternative mechanism of action of this drug.

  12. Geohydrology and ground-water quality at the Pueblo Depot activity landfill near Pueblo, Colorado

    USGS Publications Warehouse

    Watts, Kenneth R.; Ortiz, Roderick F.

    1990-01-01

    Groundwater samples were collected from the shallow unconfined aquifer at the Pueblo Depot Activity (Colorado) landfill and downstream from the landfill. The Pueblo Depot Activity is a U.S. Department of the Army facility in southeastern Colorado about 15 miles east of Pueblo, Colorado. The land-fill is underlain by upland alluvial terrace deposits that overlie a thick and almost impermeable shale. Saturated thickness of the aquifer generally is from 5 to 10 feet. Groundwater flow at the landfill is to the south-southeast toward the Arkansas River valley. Though not hydraulically connected to the upland terrace deposits, the alluvium underlying the Arkansas River valley may be recharged by groundwater that is discharged from seeps at the contact of the upland terrace deposits and the Pierre Shale. The water is classified as a mixed-cation mixed-anion type water that has concentrations of dissolved solids of 710 to 1,810 mg/L. Dissolved-solids concentrations increase downgradient. Chemical analysis, done to determine possible contamination of the groundwater, indicated that concentrations of trichloroethylene ranged from 5.2 to 2,900 microg/L and of trans-1,2-dichloroethylene ranged from 5 to 720 microg/L. The areal distribution of these volatile organic compounds indicate that there possibly are two sources of contamination of groundwater at the landfill, one upgradient from the landfill and the other within the landfill. Analysis of water samples from wells and seeps offsite and downgradient from the landfill did not indicate either contaminant in groundwater from the alluvial aquifer underlying the Arkansas River valley. (USGS)

  13. Fuels research: Fuel thermal stability overview

    NASA Technical Reports Server (NTRS)

    Cohen, S. M.

    1980-01-01

    Alternative fuels or crude supplies are examined with respect to satisfying aviation fuel needs for the next 50 years. The thermal stability of potential future fuels is discussed and the effects of these characteristics on aircraft fuel systems are examined. Advanced fuel system technology and design guidelines for future fuels with lower thermal stability are reported.

  14. FUEL ELEMENT

    DOEpatents

    Bean, R.W.

    1963-11-19

    A ceramic fuel element for a nuclear reactor that has improved structural stability as well as improved cooling and fission product retention characteristics is presented. The fuel element includes a plurality of stacked hollow ceramic moderator blocks arranged along a tubular raetallic shroud that encloses a series of axially apertured moderator cylinders spaced inwardly of the shroud. A plurality of ceramic nuclear fuel rods are arranged in the annular space between the shroud and cylinders of moderator and appropriate support means and means for directing gas coolant through the annular space are also provided. (AEC)

  15. Fuel ethanol

    SciTech Connect

    Not Available

    1989-02-01

    This report discusses the Omnibus Trade and Competitiveness Act of 1988 which requires GAO to examine fuel ethanol imports from Central America and the Caribbean and their impact on the U.S. fuel ethanol industry. Ethanol is the alcohol in beverages, such as beer, wine, and whiskey. It can also be used as a fuel by blending with gasoline. It can be made from renewable resources, such as corn, wheat, grapes, and sugarcane, through a process of fermentation. This report finds that, given current sugar and gasoline prices, it is not economically feasible for Caribbean ethanol producers to meet the current local feedstock requirement.

  16. Fuel composition

    SciTech Connect

    Badger, S.L.

    1983-09-20

    A composition useful, inter alia, as a fuel, is based on ethyl alcohol denatured with methylisobutyl alcohol and kerosene, which is mixed with xylenes and isopropyl alcohol. The xylenes and isopropyl alcohol act with the denaturizing agents to raise the flash point above that of ethyl alcohol alone and also to mask the odor and color the flame, thus making the composition safer for use as a charcoal lighter or as a fuel for e.g. patio lamps.

  17. Depot Maintenance: Status of the Public-Private Partnership for Repair of the Dual-Mode Transmitter in the F-16 Fire-Control Radar

    DTIC Science & Technology

    2015-01-27

    Partnership for Repair of the Dual-Mode Transmitter in the F-16 Fire-Control Radar A Department of Defense (DOD) instruction directs that public - private ...examine the Air Force’s public - private partnership program for the repair of the dual-mode transmitter in the F-16 fire- with Lockheed Martin for...1Department of Defense Instruction 4151.21, Public - Private Partnerships for Depot-Level Maintenance (Apr. 25, 2007). Depot maintenance is an action

  18. In-situ forming gel-like depot of a polyaspartamide-polylactide copolymer for once a week administration of sulpiride.

    PubMed

    Fiorica, Calogero; Palumbo, Fabio Salvatore; Pitarresi, Giovanna; Giorgi, Mario; Calascibetta, Filippo; Giammona, Gaetano

    2015-01-01

    An in-situ forming gel-like depot, prepared by using an appropriate polyaspartamide-polylactide graft copolymer, has been employed to release in a sustained way sulpiride. α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide-g-polylactic acid (PHEA-g-PLA) has been used as a polymer component. Its physicochemical properties make possible to dissolve it in N-methyl-2-pyrrolidone, with the obtainment of a solution able to form a gel-like depot once injected into a physiological medium. Cell compatibility of PHEA-g-PLA depot has been investigated, using murine dermal fibroblasts as cell model. 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt assay and fluorescence microscopy have been employed to evaluate cell viability and morphology after contact with PHEA-g-PLA depot. Pharmacokinetic parameters of sulpiride released from depot have been determined following subcutaneous administration to rabbits and compared with corresponding parameters following administration of free sulpiride solution. It has been demonstrated that the system does not affect significantly the viability of fibroblasts and is able to sustain the release of sulpiride until a week, with a burst effect dependent on the initial weight ratio polymer/drug. In-vivo release profiles and pharmacokinetic parameters suggest that PHEA-g-PLA depot could have interesting clinical applications for a once a week administration of poorly soluble drugs to humans or animals. © 2014 Royal Pharmaceutical Society.

  19. An Ant Colony Optimization algorithm for solving the fixed destination multi-depot multiple traveling salesman problem with non-random parameters

    NASA Astrophysics Data System (ADS)

    Ramadhani, T.; Hertono, G. F.; Handari, B. D.

    2017-07-01

    The Multiple Traveling Salesman Problem (MTSP) is the extension of the Traveling Salesman Problem (TSP) in which the shortest routes of m salesmen all of which start and finish in a single city (depot) will be determined. If there is more than one depot and salesmen start from and return to the same depot, then the problem is called Fixed Destination Multi-depot Multiple Traveling Salesman Problem (MMTSP). In this paper, MMTSP will be solved using the Ant Colony Optimization (ACO) algorithm. ACO is a metaheuristic optimization algorithm which is derived from the behavior of ants in finding the shortest route(s) from the anthill to a form of nourishment. In solving the MMTSP, the algorithm is observed with respect to different chosen cities as depots and non-randomly three parameters of MMTSP: m, K, L, those represents the number of salesmen, the fewest cities that must be visited by a salesman, and the most number of cities that can be visited by a salesman, respectively. The implementation is observed with four dataset from TSPLIB. The results show that the different chosen cities as depots and the three parameters of MMTSP, in which m is the most important parameter, affect the solution.

  20. Depot-Specific Response of Adipose Tissue to Diet-Induced Inflammation: The Retinoid-Related Orphan Receptor α (RORα) Involved?

    PubMed

    Kadiri, Sarah; Auclair, Martine; Capeau, Jacqueline; Antoine, Bénédicte

    2017-09-20

    Epididymal adipose tissue (EAT), a visceral fat depot, is more closely associated with metabolic dysfunction than inguinal adipose tissue (IAT), a subcutaneous depot. This study evaluated whether the nuclear receptor RORα, which controls inflammatory processes, could be implicated. EAT and IAT were compared in a RORα loss-of-function mouse (sg/sg) and in wild-type (WT) littermates, fed a standard diet (SD) or a Western diet (WD), to evaluate the impact of RORα expression on inflammatory status and on insulin sensitivity (IS) of each fat depot according to the diet. Sg/sg mice fed the SD exhibited a decreased inflammatory status and a higher IS in their fat depots than WT mice. WD-induced obesity had distinct effects on the two fat depots. In WT mice, EAT exhibited increased inflammation and insulin resistance while IAT showed reduced inflammation and improved IS, together with a depot-specific increase of RORα, and its target gene IκBα, in the stroma vascular fraction (SVF). Conversely, in sg/sg mice, WD increased inflammation and lowered IS of IAT but not of EAT. These findings suggest an anti-inflammatory role for RORα in response to WD, which occurs at the level of SVF of IAT, thus possibly contributing to the "healthy" expansion of IAT. © 2017 The Obesity Society.